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Sample records for generalized stiffness coefficients

  1. Elastic-Stiffness Coefficients of Titanium Diboride

    PubMed Central

    Ledbetter, Hassel; Tanaka, Takaho

    2009-01-01

    Using resonance ultrasound spectroscopy, we measured the monocrystal elastic-stiffness coefficients, the Voigt Cij, of TiB2. With hexagonal symmetry, TiB2 exhibits five independent Cij: C11, C33, C44, C12, C13. Using Voigt-Reuss-Hill averaging, we converted these monocrystal values to quasiisotropic (polycrystal) elastic stiffnesses. Briefly, we comment on effects of voids. From the Cij, we calculated the Debye characteristic temperature, the Grüneisen parameter, and various sound velocities. Our study resolves the enormous differences between two previous reports of TiB2’s Cij. PMID:27504232

  2. Is tendon stiffness correlated to the dissipation coefficient?

    PubMed

    Fouré, A; Cornu, C; Nordez, A

    2012-01-01

    The assessment of Achilles tendon mechanical properties in vivo has received much attention in the literature. Many studies investigated mechanical properties by assessing tendon stiffness. Despite tendon dissipative properties being representative of a storage-recoil process, its determination has received minimal attention in the literature. The aim of this study was to determine if Achilles tendon stiffness is associated with dissipative properties. The cross-sectional area, stiffness and dissipation coefficient of the Achilles tendon were measured in 35 subjects. No significant correlation was found between stiffness and the dissipation coefficient, irrespective of stiffness normalization with cross-sectional area (P > 0.05). Thus, it appears that both stiffness and dissipative properties must be assessed to determine the storage-recoil process capacities of the Achilles tendon in order to precisely characterize changes in the tendon mechanical properties after chronic interventions or rehabilitation programs.

  3. Tilting pad journal bearings - Measured and predicted stiffness coefficients

    SciTech Connect

    Parkins, D.W.; Horner, D. Michell Bearings, Newcastle-upon-Tyne )

    1993-07-01

    This paper presents measured and calculated characteristics of a tilting pad journal bearing suitable for high speed machinery. Descriptions are given of the experimental techniques used with this variety of bearing and the theoretical model for predicting performance. Measured values of pad temperature, eccentricity, attitude angle, and the four stiffness coefficients are given for a range of loads and rotational speeds. Data are given for both load on pad and between pad configurations, the two principal loading arrangements. Comparisons are made between the measured and predicted bearing temperatures and stiffness coefficients over a wide range of values. 11 refs.

  4. Tilting pad journal bearings - Measured and predicted stiffness coefficients

    NASA Astrophysics Data System (ADS)

    Parkins, D. W.; Horner, D.

    1993-07-01

    This paper presents measured and calculated characteristics of a tilting pad journal bearing suitable for high speed machinery. Descriptions are given of the experimental techniques used with this variety of bearing and the theoretical model for predicting performance. Measured values of pad temperature, eccentricity, attitude angle, and the four stiffness coefficients are given for a range of loads and rotational speeds. Data are given for both load on pad and between pad configurations, the two principal loading arrangements. Comparisons are made between the measured and predicted bearing temperatures and stiffness coefficients over a wide range of values.

  5. Stiffness Coefficients Measurement of Cylindrical Rods by Laser Ultrasonics

    NASA Astrophysics Data System (ADS)

    Pan, Y.; Rossignol, C.; Audoin, B.

    2004-02-01

    A non-contact laser-ultrasonic technique is applied to the nondestructive measurement of the stiffness properties of cylindrical rods. Acoustic waves generated in a cylinder by a laser line source under thermoelastic regime are identified by the comparison between experiment and theory. Two stiffness coefficients c11 and c12 are determined by measuring the arrival time of the reflected longitudinal wave (LL) and that of the head wave (HW). The effects of laser beamwidth and time duration on the measurement are found by numerical simulations. For such an application, a radius of 0.3 mm appears as a minimum limit for the sample size using a laser source of 0.1 mm beamwidth and 20 ns time duration. Stiffness coefficients of three aluminum rods are experimentally measured with good accuracy.

  6. Identities for generalized hypergeometric coefficients

    SciTech Connect

    Biedenharn, L.C.; Louck, J.D.

    1991-01-01

    Generalizations of hypergeometric functions to arbitrarily many symmetric variables are discussed, along with their associated hypergeometric coefficients, and the setting within which these generalizations arose. Identities generalizing the Euler identity for {sub 2}F{sub 1}, the Saalschuetz identity, and two generalizations of the {sub 4}F{sub 3} Bailey identity, among others, are given. 16 refs.

  7. Note on Two Generalizations of Coefficient Alpha.

    ERIC Educational Resources Information Center

    Raju, Nambury S.

    1979-01-01

    An important relationship is given for two generalizations of coefficient alpha: (1) Rajaratnam, Cronbach, and Gleser's generalizability formula for stratified-parallel tests, and (2) Raju's coefficient beta. (Author/CTM)

  8. Characterization of superconducting magnetic bearings (dynamic stiffness and damping coefficient in axial direction)

    NASA Technical Reports Server (NTRS)

    Takahata, Ryoichi; Ueyama, Hirochika; Yotsuya, Tsutom

    1992-01-01

    High T(sub c) superconductor as a stator and permanent magnets for a rotor were assembled into a superconducting magnetic bearing. The dynamic stiffness and the damping coefficient of the superconducting magnetic bearing in axial direction were measured. The dynamic stiffness depended on an axial gap between superconductor and permanent magnet. The superconducting magnetic bearings are advantageous for a passive bearing, because they have a vibration damping effect that a permanent magnet bearing does not have. The tendency of its vibration damping coefficient indicated an increase as the resonant frequency increased.

  9. Stiffness and Damping Coefficient Estimation of Compliant Surface Gas Bearings for Oil-Free Turbomachinery

    NASA Technical Reports Server (NTRS)

    DellaCorte, Christopher

    2010-01-01

    Foil gas bearings are a key technology in many commercial and emerging Oil-Free turbomachinery systems. These bearings are non-linear and have been difficult to analytically model in terms of performance characteristics such as load capacity, power loss, stiffness and damping. Previous investigations led to an empirically derived method, a rule-of-thumb, to estimate load capacity. This method has been a valuable tool in system development. The current paper extends this tool concept to include rules for stiffness and damping coefficient estimation. It is expected that these rules will further accelerate the development and deployment of advanced Oil-Free machines operating on foil gas bearings

  10. Stiffness and Damping Coefficient Estimation of Compliant Surface Gas Bearings for Oil-Free Turbomachinery

    NASA Technical Reports Server (NTRS)

    Della-Corte, Christopher

    2012-01-01

    Foil gas bearings are a key technology in many commercial and emerging oilfree turbomachinery systems. These bearings are nonlinear and have been difficult to analytically model in terms of performance characteristics such as load capacity, power loss, stiffness, and damping. Previous investigations led to an empirically derived method to estimate load capacity. This method has been a valuable tool in system development. The current work extends this tool concept to include rules for stiffness and damping coefficient estimation. It is expected that these rules will further accelerate the development and deployment of advanced oil-free machines operating on foil gas bearings.

  11. General frost growth mechanism on solid substrates with different stiffness.

    PubMed

    Petit, Julien; Bonaccurso, Elmar

    2014-02-01

    Preventing or delaying frost formation on surfaces is of significant importance in many aspects of our daily life. Despite many efforts and improvements recently achieved in the design of new icephobic materials and substrates, not all proposed solutions are universally applicable and frost formation still remains a problem in need of further flexible solutions. In this respect, we propose to take benefit from the tunable viscoelastic properties of soft polymer gel substrates, since they are known to strongly influence the dropwise condensation process of water, and to investigate condensation frosting on them. Using polymer gels with different stiffness and a hard substrate as a reference, we demonstrate their ability to delay frost formation compared to recent results reported in the literature on other solid substrates and in particular on superhydrophobic surfaces. By investigating the frost front propagation we singled out a general behavior of its dynamic evolution consisting of two processes presenting two different time scales. This general growth appears to be independent of experimental conditions as well as substrate stiffness.

  12. Determination of Nonlinear Stiffness Coefficients for Finite Element Models with Application to the Random Vibration Problem

    NASA Technical Reports Server (NTRS)

    Muravyov, Alexander A.

    1999-01-01

    In this paper, a method for obtaining nonlinear stiffness coefficients in modal coordinates for geometrically nonlinear finite-element models is developed. The method requires application of a finite-element program with a geometrically non- linear static capability. The MSC/NASTRAN code is employed for this purpose. The equations of motion of a MDOF system are formulated in modal coordinates. A set of linear eigenvectors is used to approximate the solution of the nonlinear problem. The random vibration problem of the MDOF nonlinear system is then considered. The solutions obtained by application of two different versions of a stochastic linearization technique are compared with linear and exact (analytical) solutions in terms of root-mean-square (RMS) displacements and strains for a beam structure.

  13. Comment on "Generalized exclusion processes: Transport coefficients"

    NASA Astrophysics Data System (ADS)

    Becker, T.; Nelissen, K.; Cleuren, B.; Partoens, B.; Van den Broeck, C.

    2016-04-01

    In a recent paper, Arita et al. [Phys. Rev. E 90, 052108 (2014), 10.1103/PhysRevE.90.052108] consider the transport properties of a class of generalized exclusion processes. Analytical expressions for the transport-diffusion coefficient are derived by ignoring correlations. It is claimed that these expressions become exact in the hydrodynamic limit. In this Comment, we point out that (i) the influence of correlations upon the diffusion does not vanish in the hydrodynamic limit, and (ii) the expressions for the self- and transport diffusion derived by Arita et al. are special cases of results derived in Becker et al. [Phys. Rev. Lett. 111, 110601 (2013), 10.1103/PhysRevLett.111.110601].

  14. Planar lattices with tailorable coefficient of thermal expansion and high stiffness based on dual-material triangle unit

    NASA Astrophysics Data System (ADS)

    Wei, Kai; Chen, Haosen; Pei, Yongmao; Fang, Daining

    2016-01-01

    The unexpected thermal distortions and failures in engineering raise the big concern about thermal expansion controlling. Thus, design of tailorable coefficient of thermal expansion (CTE) is urgently needed for the materials used in large temperature variation circumstance. Here, inspired by multi-fold rotational symmetry in crystallography, we have devised six kinds of periodic planar lattices, which incorporate tailorable CTE and high specific biaxial stiffness. Fabrication process, which overcame shortcomings of welding or adhesion connection, was developed for the dual-material planar lattices. The analytical predictions agreed well with the CTE measurements. It is shown that the planar lattices fabricated from positive CTE constituents, can give large positive, near zero and even negative CTEs. Furthermore, a generalized stationary node method was proposed for aperiodic lattices and even arbitrary structures with desirable thermal expansion. As an example, aperiodic quasicrystal lattices were designed and exhibited zero thermal expansion property. The proposed method for the lattices of lightweight, robust stiffness, strength and tailorable thermal expansion is useful in the engineering applications.

  15. Optimization of the contact damping and stiffness coefficients to minimize human body vibration.

    PubMed

    Amirouche, F M; Xie, M; Patwardhan, A

    1994-11-01

    In this paper, a lumped mass human model is used to minimize the energy absorption at the feet/hip level when the body is subjected to vertical vibration. The contact forces are assumed unknown. By coupling the dynamic response of the body with certain objective criteria, the optimum damping and stiffness coefficients of shoes/chairs are sought. The optimization technique is based on the quasi-Newton and finite-difference gradient method and is used to seek optimum coefficients of the contact forces in the solution of the body's response in the frequency domain. The criteria of acceleration, displacement and internal forces response area swept for a range of 0-15 Hz form the basis of our simulation study. In the seated/standing postures it is found that for each criteria the frequency response shifts the peak of resonance of each body segment response from 4.5/3.67 Hz to 2.5/2.255 Hz. In addition, the total energy reduces drastically when the contact conditions are optimum. The method presented in this paper is useful in modeling the medium of contacts and especially in controlling the effects of human body vibration.

  16. Generalized skew coefficients for flood-frequency analysis in Minnesota

    USGS Publications Warehouse

    Lorenz, D.L.

    1997-01-01

    This report presents an evaluation of generalized skew coefficients used in flood-frequency analysis. Station skew coefficients were computed for 267 long-term stream-gaging stations in Minnesota and the surrounding states of Iowa, North and South Dakota, Wisconsin, and the provinces of Manitoba and Ontario, Canada. Generalized skew coefficients were computed from station skew coefficients using a locally weighted regression technique. The resulting regression trend surface was the generalized skew coefficient map, except for the North Shore area, and has a mean square error of 0.182.

  17. Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population.

    PubMed

    Mayer, O; Seidlerová, J; Wohlfahrt, P; Filipovský, J; Vaněk, J; Cífková, R; Windrichová, J; Topolčan, O; Knapen, M H J; Drummen, N E A; Vermeer, C

    2016-07-01

    Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and muscular-type large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P<0.0001) increased across the dp-ucMGP quartiles. After adjustment for all potential confounders, aortic PWV independently correlated with dp-ucMGP (with beta coefficient (s.d.) 11.61 (5.38) and P-value=0.031). In a categorized manner, subjects in the top quartile of dp-ucMGP (⩾ 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries.

  18. Desphospho-uncarboxylated matrix Gla protein is associated with increased aortic stiffness in a general population.

    PubMed

    Mayer, O; Seidlerová, J; Wohlfahrt, P; Filipovský, J; Vaněk, J; Cífková, R; Windrichová, J; Topolčan, O; Knapen, M H J; Drummen, N E A; Vermeer, C

    2016-07-01

    Matrix Gla protein (MGP), a natural inhibitor of calcification, strongly correlates with the extent of coronary calcification. Vitamin K is the essential cofactor for the activation of MGP. The nonphosphorylated-uncarboxylated isoform of MGP (dp-ucMGP) reflects the status of this vitamin. We investigated whether there is an association between dp-ucMGP and stiffness of elastic and muscular-type large arteries in a random sample from the general population. In a cross-sectional design, we analyzed 1087 subjects from the Czech post-MONICA study. Aortic and femoro-popliteal pulse wave velocities (PWVs) were measured using a Sphygmocor device. Dp-ucMGP concentrations were assessed in freshly frozen samples by enzyme-linked immunosorbent assay methods using the InaKtif MGP iSYS pre-commercial kit developed by IDS and VitaK. Aortic PWV significantly (P<0.0001) increased across the dp-ucMGP quartiles. After adjustment for all potential confounders, aortic PWV independently correlated with dp-ucMGP (with beta coefficient (s.d.) 11.61 (5.38) and P-value=0.031). In a categorized manner, subjects in the top quartile of dp-ucMGP (⩾ 671 pmol l(-1)) had a higher risk of elevated aortic PWV, with corresponding adjusted odds ratio (95% confidence interval) 1.73 (1.17-2.5). In contrast, no relation between dp-ucMGP and femoro-popliteal PWV was found. In conclusion, increased dp-ucMGP, which is a circulating biomarker of vitamin K status and vascular calcification, is independently associated with aortic stiffness, but not with stiffness of distal muscular-type arteries. PMID:26016598

  19. Dynamic stiffness matrix of a rectangular plate for the general case

    NASA Astrophysics Data System (ADS)

    Banerjee, J. R.; Papkov, S. O.; Liu, X.; Kennedy, D.

    2015-04-01

    The dynamic stiffness matrix of a rectangular plate for the most general case is developed by solving the bi-harmonic equation and finally casting the solution in terms of the force-displacement relationship of the freely vibrating plate. Essentially the frequency dependent dynamic stiffness matrix of the plate when all its sides are free is derived, making it possible to achieve exact solution for free vibration of plates or plate assemblies with any boundary conditions. Previous research on the dynamic stiffness formulation of a plate was restricted to the special case when the two opposite sides of the plate are simply supported. This restriction is quite severe and made the general purpose application of the dynamic stiffness method impossible. The theory developed in this paper overcomes this long-lasting restriction. The research carried out here is basically fundamental in that the bi-harmonic equation which governs the free vibratory motion of a plate in harmonic oscillation is solved in an exact sense, leading to the development of the dynamic stiffness method. It is significant that the ingeniously sought solution presented in this paper is completely general, covering all possible cases of elastic deformations of the plate. The Wittrick-Williams algorithm is applied to the ensuing dynamic stiffness matrix to provide solutions for some representative problems. A carefully selected sample of mode shapes is also presented.

  20. Ultrasound assisted optical elastography for measurement of tissue stiffness: contribution to the measurement from scattering coefficient variation

    NASA Astrophysics Data System (ADS)

    Bharat Chandran, R. S.; Usha Devi, C.; Vasu, R. M.; Sood, A. K.

    2007-05-01

    In ultrasound assisted optical elastography (UAOE) the amplitude of vibration inside the object introduced by an ultrasound (US) beam is read out by a coherent light beam. The measurement is the depth of modulation in the intensity autocorrelation of light that intercepted the insonified region and detected at the boundary. It is observed that the measured depth of modulation is owing to refractive index modulation and scattering coefficient modulation, in addition to the tissue-particle vibration. Since elasticity is measured from the amplitude of vibration it is essential to characterize and separate the contribution to the modulation from refractive index and scattering coefficient modulations. In this work we report the contribution of the scattering coefficient modulation in the insonified region to the measured modulation in the autocorrelation. We found through simulation studies that the contribution from scattering coefficient is small compared to the vibration. In addition, this contribution becomes smaller as the stiffness in the region increases. We also provide a means of quantifying this contribution so that the effect of vibration amplitude can be separated from the overall measured modulation depth.

  1. Linear equations in general purpose codes for stiff ODEs

    SciTech Connect

    Shampine, L. F.

    1980-02-01

    It is noted that it is possible to improve significantly the handling of linear problems in a general-purpose code with very little trouble to the user or change to the code. In such situations analytical evaluation of the Jacobian is a lot cheaper than numerical differencing. A slight change in the point at which the Jacobian is evaluated results in a more accurate Jacobian in linear problems. (RWR)

  2. Non-monotonic dependence of the friction coefficient on heterogeneous stiffness

    PubMed Central

    Giacco, F.; Ciamarra, M. Pica; Saggese, L.; de Arcangelis, L.; Lippiello, E.

    2014-01-01

    The complexity of the frictional dynamics at the microscopic scale makes difficult to identify all of its controlling parameters. Indeed, experiments on sheared elastic bodies have shown that the static friction coefficient depends on loading conditions, the real area of contact along the interfaces and the confining pressure. Here we show, by means of numerical simulations of a 2D Burridge-Knopoff model with a simple local friction law, that the macroscopic friction coefficient depends non-monotonically on the bulk elasticity of the system. This occurs because elastic constants control the geometrical features of the rupture fronts during the stick-slip dynamics, leading to four different ordering regimes characterized by different orientations of the rupture fronts with respect to the external shear direction. We rationalize these results by means of an energetic balance argument. PMID:25345800

  3. Generalized transport coefficients for inelastic Maxwell mixtures under shear flow.

    PubMed

    Garzó, Vicente; Trizac, Emmanuel

    2015-11-01

    The Boltzmann equation framework for inelastic Maxwell models is considered to determine the transport coefficients associated with the mass, momentum, and heat fluxes of a granular binary mixture in spatially inhomogeneous states close to the simple shear flow. The Boltzmann equation is solved by means of a Chapman-Enskog-type expansion around the (local) shear flow distributions f(r)(0) for each species that retain all the hydrodynamic orders in the shear rate. Due to the anisotropy induced by the shear flow, tensorial quantities are required to describe the transport processes instead of the conventional scalar coefficients. These tensors are given in terms of the solutions of a set of coupled equations, which can be analytically solved as functions of the shear rate a, the coefficients of restitution α(rs), and the parameters of the mixture (masses, diameters, and composition). Since the reference distribution functions f(r)(0) apply for arbitrary values of the shear rate and are not restricted to weak dissipation, the corresponding generalized coefficients turn out to be nonlinear functions of both a and α(rs). The dependence of the relevant elements of the three diffusion tensors on both the shear rate and dissipation is illustrated in the tracer limit case, the results showing that the deviation of the generalized transport coefficients from their forms for vanishing shear rates is in general significant. A comparison with the previous results obtained analytically for inelastic hard spheres by using Grad's moment method is carried out, showing a good agreement over a wide range of values for the coefficients of restitution. Finally, as an application of the theoretical expressions derived here for the transport coefficients, thermal diffusion segregation of an intruder immersed in a granular gas is also studied.

  4. Generalized transport coefficients for inelastic Maxwell mixtures under shear flow.

    PubMed

    Garzó, Vicente; Trizac, Emmanuel

    2015-11-01

    The Boltzmann equation framework for inelastic Maxwell models is considered to determine the transport coefficients associated with the mass, momentum, and heat fluxes of a granular binary mixture in spatially inhomogeneous states close to the simple shear flow. The Boltzmann equation is solved by means of a Chapman-Enskog-type expansion around the (local) shear flow distributions f(r)(0) for each species that retain all the hydrodynamic orders in the shear rate. Due to the anisotropy induced by the shear flow, tensorial quantities are required to describe the transport processes instead of the conventional scalar coefficients. These tensors are given in terms of the solutions of a set of coupled equations, which can be analytically solved as functions of the shear rate a, the coefficients of restitution α(rs), and the parameters of the mixture (masses, diameters, and composition). Since the reference distribution functions f(r)(0) apply for arbitrary values of the shear rate and are not restricted to weak dissipation, the corresponding generalized coefficients turn out to be nonlinear functions of both a and α(rs). The dependence of the relevant elements of the three diffusion tensors on both the shear rate and dissipation is illustrated in the tracer limit case, the results showing that the deviation of the generalized transport coefficients from their forms for vanishing shear rates is in general significant. A comparison with the previous results obtained analytically for inelastic hard spheres by using Grad's moment method is carried out, showing a good agreement over a wide range of values for the coefficients of restitution. Finally, as an application of the theoretical expressions derived here for the transport coefficients, thermal diffusion segregation of an intruder immersed in a granular gas is also studied. PMID:26651684

  5. Inhomogeneous generalizations of Bianchi Type VIh universes with stiff perfect fluid and radiation

    NASA Astrophysics Data System (ADS)

    Roy, S. R.; Prasad, A.

    1995-03-01

    Families of inhomogeneous models filled with a stiff perfect fluid and radiation have been derived in which there is no flow of total momentum. The models are generalizations of those of Bianchi Type VIh and are discussed for some particular forms of the arbitrary functions appearing in them.

  6. Determination of the bead geometry considering formability and stiffness effect using generalized forming limit concept (GFLC)

    NASA Astrophysics Data System (ADS)

    Cha, Wan-Gi; Vogel, Sabrina; Bursac, Nikola; Albers, Albert; Volk, Wolfram

    2016-08-01

    Beads are used in deep drawn sheet metal parts for increasing the part stiffness. Thus, reductions of sheet metal thickness and consequently weight reduction can be reached. Style guides for types and positions of beads exist, which are often applied. However, higher stiffness effects can be realized using numeric optimization. The optimization algorithm considers the two-stepped manufacturing process consisting of deep drawing and bead stamping. The formability in both manufacturing steps represents a limiting factor. Considering nonlinear strain paths using generalized forming limit concept (GFLC), acceptable geometries will be determined in simulation. Among them, the efficient geometry which has higher stiffness effects will be selected in numerical and experimental tests. These will be integrated in the optimization algorithm.

  7. General linear mode conversion coefficient in one dimension

    NASA Astrophysics Data System (ADS)

    Littlejohn, Robert G.; Flynn, William G.

    1993-03-01

    A general formula is presented for the mode conversion coefficient for linear mode conversion in one dimension, in terms of an arbitrary 2 x 2 reduced dispersion matrix describing the coupling of the modes. The mode conversion coefficient has three invariance properties which are discussed, namely, invariance under scaling transformations, canonical transformations, and a certain kind of Lorentz transformation. Formulas for the S matrix of mode conversion are also presented. The example of the conversion of electromagnetic waves to electrostatic waves in the ionosphere is used to illustrate the formulas.

  8. General linear mode conversion coefficient in one dimension

    NASA Astrophysics Data System (ADS)

    Littlejohn, Robert G.; Flynn, William G.

    1993-03-01

    A general formula is presented for the mode conversion coefficient for linear mode conversion in one dimension, in terms of an arbitrary 2×2 reduced dispersion matrix describing the coupling of the modes. The mode conversion coefficient has three invariance properties which are discussed, namely, invariance under scaling transformations, canonical transformations, and a certain kind of Lorentz transformation. Formulas for the S matrix of mode conversion are also presented. The example of the conversion of electromagnetic waves to electrostatic waves in the ionosphere is used to illustrate the formulas.

  9. Generalizations of the clustering coefficient to weighted complex networks

    NASA Astrophysics Data System (ADS)

    Saramäki, Jari; Kivelä, Mikko; Onnela, Jukka-Pekka; Kaski, Kimmo; Kertész, János

    2007-02-01

    The recent high level of interest in weighted complex networks gives rise to a need to develop new measures and to generalize existing ones to take the weights of links into account. Here we focus on various generalizations of the clustering coefficient, which is one of the central characteristics in the complex network theory. We present a comparative study of the several suggestions introduced in the literature, and point out their advantages and limitations. The concepts are illustrated by simple examples as well as by empirical data of the world trade and weighted coauthorship networks.

  10. Second virial coefficient of a generalized Lennard-Jones potential.

    PubMed

    González-Calderón, Alfredo; Rocha-Ichante, Adrián

    2015-01-21

    We present an exact analytical solution for the second virial coefficient of a generalized Lennard-Jones type of pair potential model. The potential can be reduced to the Lennard-Jones, hard-sphere, and sticky hard-sphere models by tuning the potential parameters corresponding to the width and depth of the well. Thus, the second virial solution can also regain the aforementioned cases. Moreover, the obtained expression strongly resembles the one corresponding to the Kihara potential. In fact, the Fk functions are the same. Furthermore, for these functions, the complete expansions at low and high temperature are given. Additionally, we propose an alternative stickiness parameter based on the obtained second virial coefficient.

  11. GYutsis: heuristic based calculation of general recoupling coefficients

    NASA Astrophysics Data System (ADS)

    Van Dyck, D.; Fack, V.

    2003-08-01

    General angular momentum recoupling coefficients can be expressed as a summation formula over products of 6- j coefficients. Yutsis, Levinson and Vanagas developed graphical techniques for representing the general recoupling coefficient as a cubic graph and they describe a set of reduction rules allowing a stepwise generation of the corresponding summation formula. This paper is a follow up to [Van Dyck and Fack, Comput. Phys. Comm. 151 (2003) 353-368] where we described a heuristic algorithm based on these techniques. In this article we separate the heuristic from the algorithm and describe some new heuristic approaches which can be plugged into the generic algorithm. We show that these new heuristics lead to good results: in many cases we get a more efficient summation formula than our previous approach, in particular for problems of higher order. In addition the new features and the use of our program GYutsis, which implements these techniques, is described both for end users and application programmers. Program summaryTitle of program: CycleCostAlgorithm, GYutsis Catalogue number: ADSA Program Summary URL:http://cpc.cs.qub.ac.uk/summaries/ADSA Program obtainable from: CPC Program Library, Queen's University of Belfast, N. Ireland. Users may obtain the program also by downloading either the compressed tar file gyutsis.tgz (for Unix and Linux) or the zip file gyutsis.zip (for Windows) from our website ( http://caagt.rug.ac.be/yutsis/). An applet version of the program is also available on our website and can be run in a web browser from the URL http://caagt.rug.ac.be/yutsis/GYutsisApplet.html. Licensing provisions: none Computers for which the program is designed: any computer with Sun's Java Runtime Environment 1.4 or higher installed. Programming language used: Java 1.2 (Compiler: Sun's SDK 1.4.0) No. of lines in program: approximately 9400 No. of bytes in distributed program, including test data, etc.: 544 117 Distribution format: tar gzip file Nature of

  12. A graphical algorithm for fast computation of identity coefficients and generalized kinship coefficients

    PubMed Central

    Abney, Mark

    2009-01-01

    Summary: Computing the probability of identity by descent sharing among n genes given only the pedigree of those genes is a computationally challenging problem, if n or the pedigree size is large. Here, I present a novel graphical algorithm for efficiently computing all generalized kinship coefficients for n genes. The graphical description transforms the problem from doing many recursion on the pedigree to doing a single traversal of a structure referred to as the kinship graph. Availability: The algorithm is implemented for n = 4 in the software package IdCoefs at http://home.uchicago.edu/abney/Software.html. Contact: abney@bsd.uchicago.edu Supplementary Information:Supplementary data are available at Bioinformatics online. PMID:19359355

  13. Generalized semiparametric varying-coefficient models for longitudinal data

    NASA Astrophysics Data System (ADS)

    Qi, Li

    In this dissertation, we investigate the generalized semiparametric varying-coefficient models for longitudinal data that can flexibly model three types of covariate effects: time-constant effects, time-varying effects, and covariate-varying effects, i.e., the covariate effects that depend on other possibly time-dependent exposure variables. First, we consider the model that assumes the time-varying effects are unspecified functions of time while the covariate-varying effects are parametric functions of an exposure variable specified up to a finite number of unknown parameters. The estimation procedures are developed using multivariate local linear smoothing and generalized weighted least squares estimation techniques. The asymptotic properties of the proposed estimators are established. The simulation studies show that the proposed methods have satisfactory finite sample performance. ACTG 244 clinical trial of HIV infected patients are applied to examine the effects of antiretroviral treatment switching before and after HIV developing the 215-mutation. Our analysis shows benefit of treatment switching before developing the 215-mutation. The proposed methods are also applied to the STEP study with MITT cases showing that they have broad applications in medical research.

  14. Bone Strength and Arterial Stiffness Impact on Cardiovascular Mortality in a General Population

    PubMed Central

    Avramovska, Maja; Sikole, Aleksandar

    2016-01-01

    Osteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with 36-month follow-up period. DXA assessed bone mineral density of femoral neck (BMD FN) and lumbar spine (BMD LS). Carotid-femoral PWV was assessed by pulsed-Doppler. The aim of our study is to find correlation between bone strength and arterial stiffness and their impact on cardiovascular mortality in GP. The mean ± SD of BMD FN, BMD LS, and PWV was 0.852 ± 0.1432 g/cm2, 0.934 ± 0.1546 g/cm2, and 9.209 ± 1.9815 m/s. In multiple regression analysis we found BMD FN (βst = −6.0094, p < 0.0001), hypertension (βst = 1.7340, p < 0.0091), and diabetes (βst = 0.4595, p < 0.0046). With Cox-regression analysis, after 17 cardiovascular events, the significant covariates retained by the backward model were BMD FN (b = −2.4129, p = 0.015) and PWV (b = 0.2606, p = 0.0318). The cut-off values were PWV = 9.4 m/s, BMD FN = 0.783 g/cm2, and BMD LS = 0.992 g/cm2. The results for BMD FN and PWV hazard ratio risk were 1.116 and 1.297, respectively. BMD FN as a measure of bone strength and PWV as a measure of arterial stiffness are strong independent predictors of cardiovascular mortality in GP. PMID:27047700

  15. General relativistic radiation hydrodynamics of accretion flows - II. Treating stiff source terms and exploring physical limitations

    NASA Astrophysics Data System (ADS)

    Roedig, C.; Zanotti, O.; Alic, D.

    2012-10-01

    We present the implementation of an implicit-explicit (IMEX) Runge-Kutta numerical scheme for general relativistic (GR) hydrodynamics coupled to an optically thick radiation field in two existing GR-(magneto)hydrodynamics codes. We argue that the necessity of such an improvement arises naturally in most astrophysically relevant regimes where the optical thickness is high as the equations become stiff. By performing several simple 1D tests, we verify the codes' new ability to deal with this stiffness and show consistency. Then, still in one spatial dimension, we compute a luminosity versus accretion rate diagram for the set-up of spherical accretion on to a Schwarzschild black hole and find good agreement with previous work which included more radiation processes than we currently have available. Lastly, we revisit the supersonic Bondi-Hoyle-Lyttleton (BHL) accretion in two dimensions where we can now present simulations of realistic temperatures, down to T ˜ 106 K or less. Here we find that radiation pressure plays an important role, but also that these highly dynamical set-ups push our approximate treatment towards the limit of physical applicability. The main features of radiation hydrodynamics BHL flows manifest as (i) an effective adiabatic index approaching γeff ˜ 4/3; (ii) accretion rates two orders of magnitude lower than without radiation pressure, but still super-Eddington; (iii) luminosity estimates around the Eddington limit, hence with an overall radiative efficiency as small as ηBHL˜10-2; (iv) strong departures from thermal equilibrium in shocked regions; (v) no appearance of the flip-flop instability. We conclude that the current optically thick approximation to the radiation transfer does give physically substantial improvements over the pure hydro also in set-ups departing from equilibrium, and, once accompanied by an optically thin treatment, is likely to provide a fundamental tool for investigating accretion flows in a large variety of

  16. General dissipation coefficient in low-temperature warm inflation

    SciTech Connect

    Bastero-Gil, Mar; Berera, Arjun; Rosa, João G.; Ramos, Rudnei O. E-mail: ab@ph.ed.ac.uk E-mail: joao.rosa@ed.ac.uk

    2013-01-01

    In generic particle physics models, the inflaton field is coupled to other bosonic and fermionic fields that acquire large masses during inflation and may decay into light degrees of freedom. This leads to dissipative effects that modify the inflationary dynamics and may generate a nearly-thermal radiation bath, such that inflation occurs in a warm rather than supercooled environment. In this work, we perform a numerical computation and obtain expressions for the associated dissipation coefficient in supersymmetric models, focusing on the regime where the radiation temperature is below the heavy mass threshold. The dissipation coefficient receives contributions from the decay of both on-shell and off-shell degrees of freedom, which are dominant for small and large couplings, respectively, taking into account the light field multiplicities. In particular, we find that the contribution from on-shell decays, although Boltzmann-suppressed, can be much larger than that of virtual modes, which is bounded by the validity of a perturbative analysis. This result opens up new possibilities for realizations of warm inflation in supersymmetric field theories.

  17. Ecological optimization and coefficient of performance bounds of general refrigerators

    NASA Astrophysics Data System (ADS)

    Long, Rui; Liu, Wei

    2016-02-01

    An analysis of COP and its bounds at maximum ecological criterion for general refrigerators is conducted. For generality, both the non-isothermal heat transfer processes and the internal dissipations are considered. Under different situations, the COP under the maximum ecological criterion have been studied systematically. And the general upper and lower bounds of the optimal COP have been obtained. Furthermore under maximum ecological criterion, the COP of general endoreversible refrigerators have also been studied. And the COP bounds of different kinds of refrigerators have been analyzed. As actual refrigerators may not operate under the condition of maximum COP or maximum cooling load, but operate under the maximum ecological condition which indicates the best compromise between the refrigeration rate and the loss of refrigeration rate. This paper could provide a practical insight for designing and operating actual refrigerators.

  18. Reply to "Comment on `Generalized exclusion processes: Transport coefficients' "

    NASA Astrophysics Data System (ADS)

    Arita, Chikashi; Krapivsky, P. L.; Mallick, Kirone

    2016-07-01

    We reply to the Comment of Becker, Nelissen, Cleuren, Partoens, and Van den Broeck [Phys. Rev. E 93, 046101 (2016), 10.1103/PhysRevE.93.046101] on our article [Arita, Krapivsky, and Mallick, Phys. Rev. E 90, 052108 (2014), 10.1103/PhysRevE.90.052108] about the transport properties of a class of generalized exclusion processes.

  19. Timoshenko beam-column with generalized end conditions on elastic foundation: Dynamic-stiffness matrix and load vector

    NASA Astrophysics Data System (ADS)

    Arboleda-Monsalve, Luis G.; Zapata-Medina, David G.; Aristizabal-Ochoa, J. Darío

    2008-03-01

    The dynamic-stiffness matrix and load vector of a Timoshenko beam-column resting on a two-parameter elastic foundation with generalized end conditions are presented. The proposed model includes the frequency effects on the stiffness matrix and load vector as well as the coupling effects of: (1) bending and shear deformations along the member; (2) translational and rotational lumped masses at both ends; (3) translational and rotational masses uniformly distributed along its span; (3) axial load (tension or compression) applied at both ends; and (4) shear forces along the span induced by the applied axial load as the beam deforms according to the "modified shear equation" proposed by Timoshenko. The dynamic analyses of framed structures can be performed by including the effects of the imposed frequency ( ω>0) on the dynamic-stiffness matrix and load vector while the static and stability analyses can be carried out by making the frequency ω=0. The proposed model and corresponding dynamic-stiffness matrix and load vector represent a general solution capable to solve, just by using a single segment per element, the static, dynamic and stability analyses of any elastic framed structure made of prismatic beam-columns with semi-rigid connections resting on two-parameter elastic foundations. Analytical results indicate that the elastic behavior of framed structures made of beam-columns is frequency dependent and highly sensitive to the coupling effects just mentioned. Three comprehensive examples are presented to show the capacities and validity of the proposed method and the obtained results are compared with the finite element method and other analytical approaches.

  20. On the first G 1 stiff fluid spike solution in General Relativity

    NASA Astrophysics Data System (ADS)

    Coley, A. A.; Gregoris, D.; Lim, W. C.

    2016-11-01

    Using the Geroch transformation we obtain the first example of an exact stiff fluid spike solution to the Einstein field equations in a closed form exhibiting a spacelike G 1 group of symmetries (i.e., with a single isometry). This new solution is of Petrov type I and exhibits a spike crossing which persists to the past, which allows us to better understand spike crossings in the context of structure formation.

  1. Building Generalized Lax Integrable KdV and MKdV Equations with Spatiotemporally Varying Coefficients

    NASA Astrophysics Data System (ADS)

    Russo, M.; Choudhury, S. R.

    2014-03-01

    We present a technique based on extended Lax Pairs to derive variable-coefficient generalizations of various Lax-integrable NLPDE hierarchies. As illustrative examples, we consider generalized KdV equations, and three variants of generalized MKdV equations. It is demonstrated that the technique yields Lax- or S-integrable NLPDEs with both time- AND space-dependent coefficients which are thus more general than almost all cases considered earlier via other methods such as the Painlevé Test, Bell Polynomials, and various similarity methods. Some solutions are also presented for the generalized KdV equation derived here by the use of the Painlevé singular manifold method. Current and future work is centered on generalizing other integrable hierarchies of NLPDEs similarly, and deriving various integrability properties such as solutions, Backlund Transformations, and hierarchies of conservation laws for these new integrable systems with variable coefficients.

  2. Foundations for the generalization of the Godunov method to hyperbolic systems with stiff relaxation source terms

    NASA Astrophysics Data System (ADS)

    Hittinger, Jeffrey Alan

    2000-10-01

    Hyperbolic systems of partial differential equations with relaxation source terms arise in the modeling of many physical problems where internal processes return non-equilibrium disturbances to equilibrium. A challenge in numerically approximating such systems is that the relaxation may take place on time scales much shorter than the time scales of the flow evolution. In such cases, it is desirable for numerical methods to accurately approximate the solution even if the relaxation scales are underresolved. High-resolution Godunov methods are very successful shock-capturing algorithms for the solution of hyperbolic systems of conservation laws. It is desirable to extend this methodology to properly preserve the asymptotic behavior of hyperbolic-relaxation systems such that underresolved solutions can be accurately approximated. Godunov schemes solve or approximate Riemann problems at cell interfaces to estimate numerical fluxes that respect the physics, but, due to coupling between relaxation and wave propagation in hyperbolic-relaxation systems, the Riemann problem becomes much more complicated and its exact solution is no longer feasible. Evidence presented here suggests that to obtain robust, non-oscillatory, upwind discretizations that accurately compute underresolved solutions, aspects of this physical coupling must be included in the numerical flux calculations. A simple model system is extensively analyzed using Fourier and asymptotic analysis on both the system and its integral solution for both smooth and discontinuous initial conditions. Specifically, the early- and late-time asymptotic behaviors of the Riemann problem are determined, and the results are generalized to m x m constant-coefficient systems. A nonlinear physical example, a set of eleven macroscopic transport equations for a diatomic gas, is constructed from the Boltzmann equation and is investigated to verify the applicability of the linear analysis. Current numerical methods are reviewed, and

  3. Sensitivity of overall vehicle stiffness to local joint stiffness

    NASA Technical Reports Server (NTRS)

    Chon, Choon T.

    1987-01-01

    How overall vehicle stiffness is affected by local joint stiffness is discussed. By using the principle of virtual work and the minimum strain energy theorem, a closed form expression for the sensitivity coefficient was derived. The insensitivity of the vehicle stiffness to a particular joint, when its stiffness exceeds a certain value (or threshold value), was proven mathematically. In order to investigate the sensitivity of the structure to the joint stiffness, a so-called stick model was created, and the modeling technique is briefly described. Some data on joint stiffness of tested vehicles are also presented.

  4. Statistical Properties of Generalized Gini Coefficient with Application to Health Inequality Measurement

    ERIC Educational Resources Information Center

    Lai, Dejian; Huang, Jin; Risser, Jan M.; Kapadia, Asha S.

    2008-01-01

    In this article, we report statistical properties of two classes of generalized Gini coefficients (G1 and G2). The theoretical results were assessed via Monte Carlo simulations. Further, we used G1 and G2 on life expectancy to measure health inequalities among the provinces of China and the states of the United States. For China, the results…

  5. Junction-Generalized Riemann Problem for stiff hyperbolic balance laws in networks: An implicit solver and ADER schemes

    NASA Astrophysics Data System (ADS)

    Contarino, Christian; Toro, Eleuterio F.; Montecinos, Gino I.; Borsche, Raul; Kall, Jochen

    2016-06-01

    In this paper we design a new implicit solver for the Junction-Generalized Riemann Problem (J-GRP), which is based on a recently proposed implicit method for solving the Generalized Riemann Problem (GRP) for systems of hyperbolic balance laws. We use the new J-GRP solver to construct an ADER scheme that is globally explicit, locally implicit and with no theoretical accuracy barrier, in both space and time. The resulting ADER scheme is able to deal with stiff source terms and can be applied to non-linear systems of hyperbolic balance laws in domains consisting on networks of one-dimensional sub-domains. In this paper we specifically apply the numerical techniques to networks of blood vessels. We report on a test problem with exact solution for a simplified network of three vessels meeting at a single junction, which is then used to carry out a systematic convergence rate study of the proposed high-order numerical methods. Schemes up to fifth order of accuracy in space and time are implemented and tested. We then show the ability of the ADER scheme to deal with stiff sources through a numerical simulation in a network of vessels. An application to a physical test problem consisting of a network of 37 compliant silicon tubes (arteries) and 21 junctions, reveals that it is imperative to use high-order methods at junctions, in order to preserve the desired high order of accuracy in the full computational domain. For example, it is demonstrated that a second-order method throughout, gives comparable results to a method that is fourth order in the interior of the domain and first order at junctions.

  6. Coefficient of performance and its bounds with the figure of merit for a general refrigerator

    NASA Astrophysics Data System (ADS)

    Long, Rui; Liu, Wei

    2015-02-01

    A general refrigerator model with non-isothermal processes is studied. The coefficient of performance (COP) and its bounds at maximum χ figure of merit are obtained and analyzed. This model accounts for different heat capacities during the heat transfer processes. So, different kinds of refrigerator cycles can be considered. Under the constant heat capacity condition, the upper bound of the COP is the Curzon-Ahlborn (CA) coefficient of performance and is independent of the time durations of the heat exchanging processes. With the maximum χ criterion, in the refrigerator cycles, such as the reversed Brayton refrigerator cycle, the reversed Otto refrigerator cycle and the reversed Atkinson refrigerator cycle, where the heat capacity in the heat absorbing process is not less than that in the heat releasing process, their COPs are bounded by the CA coefficient of performance; otherwise, such as for the reversed Diesel refrigerator cycle, its COP can exceed the CA coefficient of performance. Furthermore, the general refined upper and lower bounds have been proposed.

  7. In-plane, flexural, twisting and thickness-shear coefficients for stiffness and damping of a monolayer filamentary composite, part 1

    NASA Technical Reports Server (NTRS)

    Bert, C. W.; Chang, S.

    1972-01-01

    Elastic and damping analyses resulting in determinations of the various stiffnesses and associated loss tangents for the complete characterization of the elastic and damping behavior of a monofilament composite layer are presented. For the determination of the various stiffnesses, either an elementary mechanics-of-materials formulation or a more rigorous mixed-boundary-value elasticity formulation is used. The solution for the latter formulation is obtained by means of the boundary-point least-square error technique. Kimball-Lovell type damping is assumed for each of the constituent materials. For determining the loss tangents associated with the various stiffnesses, either the viscoelastic correspondence principle or an energy analysis based on the appropriate elastic stress distribution is used.

  8. Equivalence transformations and conservation laws for a generalized variable-coefficient Gardner equation

    NASA Astrophysics Data System (ADS)

    de la Rosa, R.; Gandarias, M. L.; Bruzón, M. S.

    2016-11-01

    In this paper we study the generalized variable-coefficient Gardner equations of the form ut + A(t) unux + C(t) u2nux + B(t) uxxx + Q(t) u = 0 . This class broadens out many other equations previously considered: Johnpillai and Khalique (2010), Molati and Ramollo (2012) and Vaneeva et al. (2015). The use of the equivalence group of this class allows us to perform an exhaustive study and a simple and clear formulation of the results. Some conservation laws are derived for the nonlinearly self-adjoint equations by using a general theorem on conservation laws. We also construct conservation laws by applying the multipliers method.

  9. Measurement of activity coefficients of mixtures by head-space gas chromatography: general procedure.

    PubMed

    Luis, Patricia; Wouters, Christine; Van der Bruggen, Bart; Sandler, Stanley I

    2013-08-01

    Head-space gas chromatography (HS-GC) is an applicable method to perform vapor-liquid equilibrium measurements and determine activity coefficients. However, the reproducibility of the data may be conditioned by the experimental procedure concerning to the automated pressure-balanced system. The study developed in this work shows that a minimum volume of liquid in the vial is necessary to ensure the reliability of the activity coefficients since it may become a parameter that influences the magnitude of the peak areas: the helium introduced during the pressurization step may produce significant variations of the results when too small volume of liquid is selected. The minimum volume required should thus be evaluated prior to obtain experimentally the concentration in the vapor phase and the activity coefficients. In this work, the mixture acetonitrile-toluene is taken as example, requiring a sample volume of more than 5mL (about more than 25% of the vial volume). The vapor-liquid equilibrium and activity coefficients of mixtures at different concentrations (0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 molar fraction) and four temperatures (35, 45, 55 and 70°C) have been determined. Relative standard deviations (RSD) lower than 5% have been obtained, indicating the good reproducibility of the method when a sample volume larger than 5mL is used. Finally, a general procedure to measure activity coefficients by means of pressure-balanced head-space gas chromatography is proposed. PMID:23809803

  10. A generalized concordance correlation coefficient based on the variance components generalized linear mixed models for overdispersed count data.

    PubMed

    Carrasco, Josep L

    2010-09-01

    The classical concordance correlation coefficient (CCC) to measure agreement among a set of observers assumes data to be distributed as normal and a linear relationship between the mean and the subject and observer effects. Here, the CCC is generalized to afford any distribution from the exponential family by means of the generalized linear mixed models (GLMMs) theory and applied to the case of overdispersed count data. An example of CD34+ cell count data is provided to show the applicability of the procedure. In the latter case, different CCCs are defined and applied to the data by changing the GLMM that fits the data. A simulation study is carried out to explore the behavior of the procedure with a small and moderate sample size.

  11. General Boundary-Value Problems for the Heat Conduction Equation with Piecewise-Continuous Coefficients

    NASA Astrophysics Data System (ADS)

    Tatsii, R. M.; Pazen, O. Yu.

    2016-03-01

    A constructive scheme for the construction of a solution of a mixed problem for the heat conduction equation with piecewise-continuous coefficients coordinate-dependent in the final interval is suggested and validated in the present work. The boundary conditions are assumed to be most general. The scheme is based on: the reduction method, the concept of quasi-derivatives, the currently accepted theory of the systems of linear differential equations, the Fourier method, and the modified method of eigenfunctions. The method based on this scheme should be related to direct exact methods of solving mixed problems that do not employ the procedures of constructing Green's functions or integral transformations. Here the theorem of eigenfunction expansion is adapted for the case of coefficients that have discontinuity points of the 1st kind. The results obtained can be used, for example, in investigating the process of heat transfer in a multilayer slab under conditions of ideal thermal contact between the layers. A particular case of piecewise-continuous coefficients is considered. A numerical example of calculation of a temperature field in a real four-layer building slab under boundary conditions of the 3rd kind (conditions of convective heat transfer) that model the phenomenon of fire near one of the external surfaces is given.

  12. A method for assigning species into groups based on generalized Mahalanobis distance between habitat model coefficients

    USGS Publications Warehouse

    Williams, C.J.; Heglund, P.J.

    2009-01-01

    Habitat association models are commonly developed for individual animal species using generalized linear modeling methods such as logistic regression. We considered the issue of grouping species based on their habitat use so that management decisions can be based on sets of species rather than individual species. This research was motivated by a study of western landbirds in northern Idaho forests. The method we examined was to separately fit models to each species and to use a generalized Mahalanobis distance between coefficient vectors to create a distance matrix among species. Clustering methods were used to group species from the distance matrix, and multidimensional scaling methods were used to visualize the relations among species groups. Methods were also discussed for evaluating the sensitivity of the conclusions because of outliers or influential data points. We illustrate these methods with data from the landbird study conducted in northern Idaho. Simulation results are presented to compare the success of this method to alternative methods using Euclidean distance between coefficient vectors and to methods that do not use habitat association models. These simulations demonstrate that our Mahalanobis-distance- based method was nearly always better than Euclidean-distance-based methods or methods not based on habitat association models. The methods used to develop candidate species groups are easily explained to other scientists and resource managers since they mainly rely on classical multivariate statistical methods. ?? 2008 Springer Science+Business Media, LLC.

  13. Estimation and Inference in Generalized Additive Coefficient Models for Nonlinear Interactions with High-Dimensional Covariates

    PubMed Central

    Shujie, MA; Carroll, Raymond J.; Liang, Hua; Xu, Shizhong

    2015-01-01

    In the low-dimensional case, the generalized additive coefficient model (GACM) proposed by Xue and Yang [Statist. Sinica 16 (2006) 1423–1446] has been demonstrated to be a powerful tool for studying nonlinear interaction effects of variables. In this paper, we propose estimation and inference procedures for the GACM when the dimension of the variables is high. Specifically, we propose a groupwise penalization based procedure to distinguish significant covariates for the “large p small n” setting. The procedure is shown to be consistent for model structure identification. Further, we construct simultaneous confidence bands for the coefficient functions in the selected model based on a refined two-step spline estimator. We also discuss how to choose the tuning parameters. To estimate the standard deviation of the functional estimator, we adopt the smoothed bootstrap method. We conduct simulation experiments to evaluate the numerical performance of the proposed methods and analyze an obesity data set from a genome-wide association study as an illustration. PMID:26412908

  14. General expressions and physical origin of the coupling coefficient of arbitrary tuned coupled electromagnetic resonators

    SciTech Connect

    Elnaggar, Sameh Y.; Tervo, Richard J.; Mattar, Saba M.

    2015-11-21

    The theory and operation of various devices and systems, such as wireless power transfer via magnetic resonant coupling, magneto-inductive wave devices, magnetic resonance spectroscopy probes, and metamaterials can rely on coupled tuned resonators. The coupling strength is usually expressed in terms of the coupling coefficient κ, which can have electrical κ{sub E} and/or magnetic κ{sub M} components. In the current article, general expressions of κ are derived. The relation between the complex Poynting equation in its microscopic form and κ is made and discussed in detail. It is shown that κ can be expressed in terms of the interaction energy between the resonators' modes. It thus provides a general form that combines the magnetic and electric components of κ. The expressions make it possible to estimate the frequencies and fields of the coupled modes for arbitrarily oriented and spaced resonators. Thus, enabling the calculation of system specific parameters such as the transfer efficiency of wireless power transfer systems, resonator efficiency for electron spin resonance probes, and dispersion relations of magneto-inductive and stereo-metamaterials structures.

  15. General expressions and physical origin of the coupling coefficient of arbitrary tuned coupled electromagnetic resonators

    NASA Astrophysics Data System (ADS)

    Elnaggar, Sameh Y.; Tervo, Richard J.; Mattar, Saba M.

    2015-11-01

    The theory and operation of various devices and systems, such as wireless power transfer via magnetic resonant coupling, magneto-inductive wave devices, magnetic resonance spectroscopy probes, and metamaterials can rely on coupled tuned resonators. The coupling strength is usually expressed in terms of the coupling coefficient κ, which can have electrical κE and/or magnetic κM components. In the current article, general expressions of κ are derived. The relation between the complex Poynting equation in its microscopic form and κ is made and discussed in detail. It is shown that κ can be expressed in terms of the interaction energy between the resonators' modes. It thus provides a general form that combines the magnetic and electric components of κ. The expressions make it possible to estimate the frequencies and fields of the coupled modes for arbitrarily oriented and spaced resonators. Thus, enabling the calculation of system specific parameters such as the transfer efficiency of wireless power transfer systems, resonator efficiency for electron spin resonance probes, and dispersion relations of magneto-inductive and stereo-metamaterials structures.

  16. A computer program for two-particle generalized coefficients of fractional parentage

    NASA Astrophysics Data System (ADS)

    Deveikis, A.; Juodagalvis, A.

    2008-10-01

    We present a FORTRAN90 program GCFP for the calculation of the generalized coefficients of fractional parentage (generalized CFPs or GCFP). The approach is based on the observation that the multi-shell CFPs can be expressed in terms of single-shell CFPs, while the latter can be readily calculated employing a simple enumeration scheme of antisymmetric A-particle states and an efficient method of construction of the idempotent matrix eigenvectors. The program provides fast calculation of GCFPs for a given particle number and produces results possessing numerical uncertainties below the desired tolerance. A single j-shell is defined by four quantum numbers, (e,l,j,t). A supplemental C++ program parGCFP allows calculation to be done in batches and/or in parallel. Program summaryProgram title:GCFP, parGCFP Catalogue identifier: AEBI_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEBI_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 17 199 No. of bytes in distributed program, including test data, etc.: 88 658 Distribution format: tar.gz Programming language: FORTRAN 77/90 ( GCFP), C++ ( parGCFP) Computer: Any computer with suitable compilers. The program GCFP requires a FORTRAN 77/90 compiler. The auxiliary program parGCFP requires GNU-C++ compatible compiler, while its parallel version additionally requires MPI-1 standard libraries Operating system: Linux (Ubuntu, Scientific) (all programs), also checked on Windows XP ( GCFP, serial version of parGCFP) RAM: The memory demand depends on the computation and output mode. If this mode is not 4, the program GCFP demands the following amounts of memory on a computer with Linux operating system. It requires around 2 MB of RAM for the A=12 system at E⩽2. Computation of the A=50 particle system requires around 60 MB of

  17. Generalized entering coefficients: A criterion for foam stability against oil in porous media

    SciTech Connect

    Bergeron, V.; Fagan, M.E.; Radke, C.J.

    1993-09-01

    The unique mobility-control properties of foam in porous media make it an attractive choice as an injection fluid for enhanced oil recovery. Unfortunately, in many cases oil has a major destabilizing effect on foam. Therefore, it is important to understand how oil destabilizes foam and what surfactant properties lead to increased stability against oil. To explain the stability of foam in porous media in the presence of oil, we generalize the ideas of spreading and entering behavior using Frumkin-Deryaguin wetting theory. This formulation overcomes the inherent deficiencies in the classical spreading and entering coefficients used to explain foam stability against oil. We find that oil-tolerant foam can be produced by making the oil surface ``water wet``. To test our theoretical ideas, we measure foam-flow resistance through 45--70 {mu}m glass beadpacks, surface and interfacial tensions, and disjoining pressure isotherms for foam and pseudoemulsion films for a variety of surfactant/oil systems. Most notably, we measure pseudoemulsion-film disjoining pressure isotherms for the first time and directly establish that pseudoemulsion film stability controls the stability of the foam in the systems we tested. Moreover, we demonstrate the correspondence between stable pseudoemulsion films, negative entering behavior, and oil-tolerant foams.

  18. A generalized entering coefficient to characterize foam stability against oil in porous media

    SciTech Connect

    Bergeron, V.; Fagan, M.E.; Radke, C.J.

    1992-11-01

    This work unifies the two approaches presently accounting for oil-foam interactions: spreading behavior and thin-film stability. We demonstrate the correspondences between stable pseudoemulsion films, negative entering coeffients, and oil-tolerant foams. Frumkin-Deryaguin theory is applied to the problem of oil-foam interactions and reveals that stable pseudoemulsion films are essential to maintain oil-tolerant foams. This hypothesis is critically tested by comparing steady-state foam flow behavior in glass beadpacks that contain residual oil, with newly measured, equilibrium disjoining pressure isotherms for both foam and pseudoemulsion films, along with bulk surface and interfacial tensions. Experimental results together with similar data on a wide variety of systems lead us to conclude that highly repulsive pseudoemulsion film disjoining pressure isotherms (i.e., stable pseudoemulsion films) produce negative generalized entering coefficients and oil-tolerant foams. This in turn provides us with a surfactant design criterion needed to produce oil-tolerant foam in porous media.

  19. Transformations of spherical beam shape coefficients in generalized Lorenz-Mie theories through rotations of coordinate systems. IV. Plane waves

    NASA Astrophysics Data System (ADS)

    Gouesbet, G.; Wang, J. J.; Han, Y. P.; G. Grehan

    2010-09-01

    This paper is the fourth of a series devoted to the transformation of beam shape coefficients through rotations of coordinate systems. These coefficients are required to express electromagnetic fields of laser beams in expanded forms, for instance for use in some generalized Lorenz-Mie theories. The main result of Part I has been the theorem of transformation of beam shape coefficients under rotations. Part II dealt with the special case of on-axis axisymmetric beams. Part III dealt with other special cases, namely when the Euler angles specifying the rotation are given some special values. The present Part IV studies another special case, namely the one of plane waves viewed as special on-axis axisymmetric beams, and can therefore be viewed as a special case of Part II. Unexpectedly, it is found that, in general, although plane waves are fairly trivial, their expansions require using non trivial beam shape coefficients, exactly as required when dealing with arbitrary shaped beams.

  20. Finger Stiffness.

    PubMed

    Oosterhoff, Thijs C H; Nota, Sjoerd P F T; Ring, David

    2015-06-01

    Background Finger stiffness varies substantially in patients with hand and upper extremity illness and can be notably more than expected for a given pathophysiology. In prior studies, pain intensity and magnitude of disability consistently correlate with coping strategies such as catastrophic thinking and kinesiophobia, which can be characterized as overprotectiveness. In this retrospective study we address the primary research question whether patients with finger stiffness are more often overprotective when the primary pathology is outside the hand (e.g. distal radius fracture) than when it is located within the hand. Methods In an orthopaedic hand surgery department 160 patients diagnosed with more finger stiffness than expected for a given pathophysiology or time point of recovery between December 2006 and September 2012 were analyzed to compare the proportion of patients characterized as overprotective for differences by site of pathology: (1) inside the hand, (2) outside the hand, and (3) psychiatric etiology (e.g. clenched fist). Results Among 160 subjects with more finger stiffness than expected, 132 (82 %) were characterized as overprotective including 88 of 108 (81 %) with pathology in the hand, 39 of 44 (89 %) with pathology outside the hand, and 5 of 8 (63 %) with psychiatric etiology. These differences were not significant. Conclusions Overprotectiveness is common in patients with more finger stiffness than expected regardless the site and type of primary pathology. It seems worthwhile to recognize and treat maladaptive coping strategies early during recovery to limit impairment, symptoms, and disability. PMID:26078497

  1. Comparing Regression Coefficients between Nested Linear Models for Clustered Data with Generalized Estimating Equations

    ERIC Educational Resources Information Center

    Yan, Jun; Aseltine, Robert H., Jr.; Harel, Ofer

    2013-01-01

    Comparing regression coefficients between models when one model is nested within another is of great practical interest when two explanations of a given phenomenon are specified as linear models. The statistical problem is whether the coefficients associated with a given set of covariates change significantly when other covariates are added into…

  2. Riccati-type Bäcklund transformations of nonisospectral and generalized variable-coefficient KdV equations

    NASA Astrophysics Data System (ADS)

    Yang, Yun-Qing; Wang, Yun-Hu; Li, Xin; Cheng, Xue-Ping

    2014-03-01

    We extend the method of constructing Bäcklund transformations for integrable equations through Riccati equations to the nonisospectral and the variable-coefficient equations. By taking nonisospectral and generalized variable-coefficient Korteweg—de Vries (KdV) equations as examples, their Bäcklund transformations are obtained under a more generalized constrain condition. In addition, the Lax pairs and infinite numbers of conservation laws of these equations are given. Especially, some classical equations such as the cylindrical KdV equation are just the special cases of the constrain condition.

  3. Generalized Treanor-Marrone model for state-specific dissociation rate coefficients

    NASA Astrophysics Data System (ADS)

    Kunova, O.; Kustova, E.; Savelev, A.

    2016-08-01

    We propose a simple and accurate model for state-specific dissociation rate coefficients based on the widely used Treanor-Marrone model. It takes into account the dependence of its parameter on temperature and vibrational level and can be used with arbitrary vibrational ladder. The model is validated by comparisons with state-specific dissociation rate coefficients of O2 and N2 obtained using molecular dynamics, and its good accuracy is demonstrated. Non-equilibrium kinetics of O2/O and N2/N mixtures under heat bath conditions is studied; applying the optimized Treanor-Marrone model leads to more efficient dissociation and vibrational relaxation.

  4. Stiff railguns

    NASA Astrophysics Data System (ADS)

    Weldon, W. F.; Bacon, J. L.; Weeks, D. A.; Zowarka, R. C., Jr.

    1991-01-01

    Stiff guns have been operated with both plasma and solid armatures. A performance gain was seen in the plasma railgun as stiffness was increased. A stiff gun will help to maintain the bore shape and preserve the integrity of the seam between rail and insulator under the extreme asymmetric loads sustained during high-pressure operation. The hydraulically preloaded moly and ceramic gun has been fired six times at pressures as high as 87 ksi, and the bore still holds roughing vacuum up to two hours after the test. The elimination of seam leakage helps control bore erosion associated with plasma reconstitution from the rail and plasma perturbation that might result in loss-initiating instabilities. Reduced rail deflection allows solid and transitioning armatures to track the bore surface. An analysis of the strain energy associated with the deflection of the railgun structure is presented, and this mechanism is found to be a small fraction of the energy associated with armature loss and the rail resistive loss.

  5. Calculation of generalized spin stiffness constant of strongly correlated doped quantum antiferromagnet on two-dimensional lattice and it's application to effective exchange constant for semi-itinerant systems

    NASA Astrophysics Data System (ADS)

    Bhattacharjee, Suraka; Chaudhury, Ranjan

    2016-11-01

    The generalized spin stiffness constant for a doped quantum antiferromagnet has been investigated both analytically and numerically as a function of doping concentration at zero temperature, based on the strongly correlated t-J model on two-dimensional square lattice. The nature of the theoretical dependence of the stiffness constant on doping shows a striking similarity with that of the effective exchange constant, obtained from the combination of other theoretical and experimental techniques in the low doping region. This correspondence once again establishes that spin stiffness can very well play the role of an effective exchange constant even in the strongly correlated semi-itinerant systems. Our theoretical plot of the stiffness constant against doping concentration in the whole doping region exhibits the various characteristic features like a possible crossover in the higher doping regions and persistence of short range ordering even for very high doping with the complete vanishing of spin stiffness occurring only close to 100% doping. Our results receive very good support from various other theoretical approaches and also brings out a few limitations of some of them. Our detailed analysis highlights the crucial importance of the study of spin stiffness for the proper understanding of magnetic correlations in a semi-itinerant magnetic system described by the strongly correlated t-J model. Moreover, our basic formalism can also be utilized for determination of the effective exchange constant and magnetic correlations for itinerant magnetic systems, in general in a novel way.

  6. Arterial Stiffness

    PubMed Central

    Avolio, Alberto

    2013-01-01

    Stiffness of large arteries has been long recognized as a significant determinant of pulse pressure. However, it is only in recent decades, with the accumulation of longitudinal data from large and varied epidemiological studies of morbidity and mortality associated with cardiovascular disease, that it has emerged as an independent predictor of cardiovascular risk. This has generated substantial interest in investigations related to intrinsic causative and associated factors responsible for the alteration of mechanical properties of the arterial wall, with the aim to uncover specific pathways that could be interrogated to prevent or reverse arterial stiffening. Much has been written on the haemodynamic relevance of arterial stiffness in terms of the quantification of pulsatile relationships of blood pressure and flow in conduit arteries. Indeed, much of this early work regarded blood vessels as passive elastic conduits, with the endothelial layer considered as an inactive lining of the lumen and as an interface to flowing blood. However, recent advances in molecular biology and increased technological sophistication for the detection of low concentrations of biochemical compounds have elucidated the highly important regulatory role of the endothelial cell affecting vascular function. These techniques have enabled research into the interaction of the underlying passive mechanical properties of the arterial wall with the active cellular and molecular processes that regulate the local environment of the load-bearing components. This review addresses these emerging concepts. PMID:26587425

  7. Coefficient of performance and its bounds for general refrigerators with nonisothermal processes

    NASA Astrophysics Data System (ADS)

    Long, Rui; Liu, Wei

    2014-08-01

    An analysis of the coefficient of performance (COP) and its bounds at maximum \\chi figure of merit for refrigerators is conducted and the heat transfer processes are described using Newton’s law of cooling with a time-dependent heat conductance. The upper bound of the COP, {{\\varepsilon }_{CA}}=\\sqrt{{{\\varepsilon }_{C}}+1}-1, is independent of the time duration completing either process or the heat conductance. The optimal temperature profiles in the heat exchanging processes are analyzed under different dimensionless contact time limits. Provided the dimensionless contact times satisfy certain relations, the endoreversible model is recovered. Furthermore, numerical calculations are conducted to investigate the effect of different heat conductances on temperature profiles under the maximum \\chi criterion. This work can guide design and operation of actual refrigerators.

  8. Stability domains of the delay and PID coefficients for general time-delay systems

    NASA Astrophysics Data System (ADS)

    Almodaresi, Elham; Bozorg, Mohammad; Taghirad, Hamid D.

    2016-04-01

    Time delays are encountered in many physical systems, and they usually threaten the stability and performance of closed-loop systems. The problem of determining all stabilising proportional-integral-derivative (PID) controllers for systems with perturbed delays is less investigated in the literature. In this study, the Rekasius substitution is employed to transform the system parameters to a new space. Then, the singular frequency (SF) method is revised for the Rekasius transformed system. A novel technique is presented to compute the ranges of time delay for which stable PID controller exists. This stability range cannot be readily computed from the previous methods. Finally, it is shown that similar to the original SF method, finite numbers of singular frequencies are sufficient to compute the stable regions in the space of time delay and controller coefficients.

  9. Generalized non-local surface susceptibility model and Fresnel coefficients for the characterization of periodic metafilms with bianisotropic scatterers

    SciTech Connect

    Dimitriadis, Alexandros I.; Kantartzis, Nikolaos V.; Tsiboukis, Theodoros D.; Hafner, Christian

    2015-01-15

    Highlights: •Formulas for E/M fields radiated by continuous surface polarization distributions. •Non-local effective surface susceptibility model for periodic metafilms. •Generalized reflection and transmission coefficients for an arbitrary metafilm. •Successful treatment of non-planar scatterer arrays and spatial dispersion effects. -- Abstract: A non-local surface susceptibility model for the consistent description of periodic metafilms formed by arbitrarily-shaped, electrically-small, bianisotropic scatterers is developed in this paper. The rigorous scheme is based on the point-dipole approximation technique and is valid for any polarization and propagation direction of an electromagnetic wave impinging upon the metafilm, unlike existing approaches whose applicability is practically confined to very specific cases of incidence. Next, the universal form of the resulting surface susceptibility matrix is employed for the derivation of the generalized Fresnel coefficients for such surfaces, which enable the comprehensive interpretation of several significant, yet relatively unexamined, physical interactions. Essentially, these coefficients include eight distinct terms, corresponding to the co-polarized and cross-polarized reflection and transmission coefficients for the two orthogonal eigenpolarizations of a linearly-polarized incident plane wave. The above formulas are, then, utilized for the prediction of the scattering properties of metafilms with different planar and non-planar resonators, which are characterized via the featured model and two previously reported local ones. Their comparison with numerical simulation outcomes substantiates the merits of the proposed method, reveals important aspects of the underlying physics, and highlights the differences between the various modeling procedures.

  10. General derivation of the sets of pedigrees with the same kinship coefficients.

    PubMed

    Pinto, Nádia; Silva, Pedro V; Amorim, António

    2010-01-01

    Quantification of kinships between two individuals using unlinked autosomal markers rests upon the identity-by-descent (IBD) probabilities among their four alleles at a locus because they determine the algebraic expressions of the joint genotypic probabilities. Nevertheless, some pedigrees share the same IBD probabilities and are therefore indistinguishable using those markers. Examples of these pedigrees were previously described, such as the case of half-siblings, grandparent-grandchild and avuncular, but a general analysis has not been attempted. The aim of this study is to present a systematic and mathematically supported framework where considering unlinked autosomal markers complete sets of indistinguishable pedigrees linking two non-inbred individuals are generally derived. In our work, complete sets of pedigrees with the same IBD partitions are formally established and mathematically treated, considering kinships linking any pair of non-inbred individuals, whether they are related just maternally or paternally, or both. Moreover, general expressions for IBD partitions, and consequently for joint genotypic probabilities, are derived considering a simple counting rule based on two 'atom' pedigrees: parent-child and full-siblings. Besides the theoretical formalization of the problem, the developed framework has potential applications in forensics as well as in breeding strategies design and in conservation studies.

  11. Variable stiffness torsion springs

    NASA Technical Reports Server (NTRS)

    Alhorn, Dean C. (Inventor); Polites, Michael E. (Inventor)

    1994-01-01

    In a torsion spring the spring action is a result of the relationships between the torque applied in twisting the spring, the angle through which the torsion spring twists, and the modulus of elasticity of the spring material in shear. Torsion springs employed industrially have been strips, rods, or bars, generally termed shafts, capabable of being flexed by twisting their axes. They rely on the variations in shearing forces to furnish an internal restoring torque. In the torsion springs herein the restoring torque is external and therefore independent of the shearing modulus of elasticity of the torsion spring shaft. Also provided herein is a variable stiffness torsion spring. This torsion spring can be so adjusted as to have a given spring constant. Such variable stiffness torsion springs are extremely useful in gimballed payloads such as sensors, telescopes, and electronic devices on such platforms as a space shuttle or a space station.

  12. Variable stiffness torsion springs

    NASA Technical Reports Server (NTRS)

    Alhorn, Dean C. (Inventor); Polites, Michael E. (Inventor)

    1995-01-01

    In a torsion spring the spring action is a result of the relationships between the torque applied in twisting the spring, the angle through which the torsion spring twists, and the modulus of elasticity of the spring material in shear. Torsion springs employed industrially have been strips, rods, or bars, generally termed shafts, capabable of being flexed by twisting their axes. They rely on the variations in shearing forces to furnish an internal restoring torque. In the torsion springs herein the restoring torque is external and therefore independent of the shearing modulus of elasticity of the torsion spring shaft. Also provided herein is a variable stiffness torsion spring. This torsion spring can be so adjusted as to have a given spring constant. Such variable stiffness torsion springs are extremely useful in gimballed payloads such as sensors, telescopes, and electronic devices on such platforms as a space shuttle or a space station.

  13. Musculoskeletal Complaints (Pain and/or Stiffness) and Their Impact on Mortality in the General Population. The Tromsø Study

    PubMed Central

    Ahmed, Luai Awad; Emaus, Nina; Klouman, Elise

    2016-01-01

    Background The long-term consequences of chronic pain and/or stiffness from the musculoskeletal system (musculoskeletal complaints: MSCs) have not been well explored. The aims of this study were to investigate whether MSCs reported at baseline influence all-cause and cause-specific mortality during 21 years follow-up of a general Northern Norwegian adult population. Methods A total of 26,977 men and women aged 25–97 years who participated in the 1994–1995 survey of the Tromsø study (response rate 77%) were included in the present prospective cohort study. Baseline data were collected from the 1994–1995 survey and information on death and emigration was taken from the National Register of Norway. Cox regression analyses were performed to examine if MSCs predicted risk of mortality. Results 5693 (21.1%) participants died during follow-up. Mean time between entry into the survey and death or emigration was 18.6 years (standard deviation 4.87) for all-cause mortality. There was an increased risk of death among those with MSCs at baseline in the crude Cox regression model. However, the multivariable model revealed no significant association between MSCs at baseline and all-cause mortality by sex (women: hazard ratio [HR] = 0.93, 95% confidence interval [CI]: 0.85–1.01; men: HR = 0.93, 95%CI: 0.85–1.01). Furthermore, no significant associations were found between widespread MSCs at baseline and all-cause mortality in multivariable models (women: HR = 0.90, 95%CI: 0.80–1.01; men HR = 0.87, 95%CI: 0.76–1.00). Analyses on cause-specific mortality did not reveal any significant results. Conclusion MSCs are not independently associated with increased risk of death from cardiovascular disease, cancer, or death from all causes. PMID:27736952

  14. Nonlinear stability of oscillatory core-annular flow: A generalized Kuramoto-Sivashinsky equation with time periodic coefficients

    NASA Technical Reports Server (NTRS)

    Coward, Adrian V.; Papageorgiou, Demetrios T.; Smyrlis, Yiorgos S.

    1994-01-01

    In this paper the nonlinear stability of two-phase core-annular flow in a pipe is examined when the acting pressure gradient is modulated by time harmonic oscillations and viscosity stratification and interfacial tension is present. An exact solution of the Navier-Stokes equations is used as the background state to develop an asymptotic theory valid for thin annular layers, which leads to a novel nonlinear evolution describing the spatio-temporal evolution of the interface. The evolution equation is an extension of the equation found for constant pressure gradients and generalizes the Kuramoto-Sivashinsky equation with dispersive effects found by Papageorgiou, Maldarelli & Rumschitzki, Phys. Fluids A 2(3), 1990, pp. 340-352, to a similar system with time periodic coefficients. The distinct regimes of slow and moderate flow are considered and the corresponding evolution is derived. Certain solutions are described analytically in the neighborhood of the first bifurcation point by use of multiple scales asymptotics. Extensive numerical experiments, using dynamical systems ideas, are carried out in order to evaluate the effect of the oscillatory pressure gradient on the solutions in the presence of a constant pressure gradient.

  15. Development of a contour map showing generalized skew coefficients of annual peak discharges of rural, unregulated streams in New York, excluding Long Island

    USGS Publications Warehouse

    Lumia, Richard; Baevsky, Yvonne H.

    2000-01-01

    Flood-frequency relations that are developed by fitting the logarithms of annual peak discharges to a Pearson Type-III distribution are sensitive to skew coefficients. Estimates of population skew for a site are improved when computed from the weighted average of (1) the sample (station) skew, and (2) an unbiased, generalized skew estimate. A weighting technique based on the number of years of record at each of 226 sites was used to develop a contour map of unbiased, generalized skew coefficients for New York. An attempt was made to group (regionalize) the station skew coefficients into five hydrologically similar areas of New York, but the statewide version proved to be as accurate as the regionalized version and therefore was adopted as the final generalized skew-coefficient map for New York. An error analysis showed the statewide contour map to have lower MSE?s (mean square errors) than those computed from (1) the five regional skewcoefficient contour maps, (2) a previously used (1982) nationwide skew coefficient map, and (3) the weighted mean of skew coefficients for sites within each of five hydrologically uniform, but distinct areas of New York.

  16. Theory versus experiment for the rotordynamic coefficients of annular gas seals. II - Constant-clearance and convergent-tapered geometry

    NASA Technical Reports Server (NTRS)

    Nelson, C. C.; Childs, D. W.; Nicks, C.; Elrod, D.

    1985-01-01

    The leakage and rotordynamic coefficients of constant-clearance and convergent-tapered annular gas seals were measured in an experimental test facility. The results are presented along with the theoretically predicted values. Of particular interest is the prediction that optimally tapered seals have significantly larger direct stiffness than straight seals. The experimental results verify this prediction. Generally the theory does quite well, but fails to predict the large increase in direct stiffness when the fluid is pre-rotated.

  17. Transformations of spherical beam shape coefficients in generalized Lorenz-Mie theories through rotations of coordinate systems. V. Localized beam models

    NASA Astrophysics Data System (ADS)

    Gouesbet, G.; Lock, J. A.; Wang, J. J.; Gréhan, G.

    2011-01-01

    This paper is the fifth of a series of papers devoted to the transformation of beam shape coefficients through rotations of coordinate systems. These coefficients are required to express electromagnetic fields of laser beams in expanded forms, for use in some generalized Lorenz-Mie theories, or in other light scattering approaches such as Extended Boundary Condition Method. Part I was devoted to the general formulation. Parts II, III, IV were devoted to special cases, namely axisymmetric beams, special values of Euler angles, and plane waves respectively. The present Part V is devoted to the study of localized approximation and localized beam models, and of their behavior under the rotation of coordinate systems.

  18. Stiff Person Syndrome.

    PubMed

    Saigal, Renu; Goyal, Laxmikant; Yadav, Rn; Agrawal, Abhishek; Mital, Pradeep; Patel, Bhavesh

    2015-08-01

    Stiff-person syndrome or Moersch-Woltmann is a very rare and disabling neurologic disorder characterized by muscle rigidity and episodic spasms involving axial and limb musculature. It is an autoimmune disorder resulting in a malfunction of aminobutyric acid mediated inhibitory networks in the central nervous system. We describe a patient of stiff person syndrome. PMID:27604442

  19. Rigorous Justification of the Localized Approximation to the Beam-Shape Coefficients in Generalized Lorenz-Mie Theory. Part 1; On-Axis Beams

    NASA Technical Reports Server (NTRS)

    Lock, James A.; Gouesbet, Gerard

    1994-01-01

    Generalized Lorenz-Mie theory describes electromagnetic scattering of an arbitrary light beam by a spherical particle. The computationally most expensive feature of the theory is the evaluation of the beam-shape coefficients, which give the decomposition of the incident light beam into partial waves. The so-called localized approximation to these coefficients for a focused Gaussian beam is an analytical function whose use greatly simplifies Gaussian-beam scattering calculations. A mathematical justification and physical interpretation of the localized approximation is presented for on-axis beams.

  20. Arterial Stiffness Gradient

    PubMed Central

    Fortier, Catherine; Agharazii, Mohsen

    2016-01-01

    Background Aortic stiffness is a strong predictor of cardiovascular mortality in various clinical conditions. The aim of this review is to focus on the arterial stiffness gradient, to discuss the integrated role of medium-sized muscular conduit arteries in the regulation of pulsatile pressure and organ perfusion and to provide a rationale for integrating their mechanical properties into risk prediction. Summary The physiological arterial stiffness gradient results from a higher degree of vascular stiffness as the distance from the heart increases, creating multiple reflective sites and attenuating the pulsatile nature of the forward pressure wave along the arterial tree down to the microcirculation. The stiffness gradient hypothesis simultaneously explains its physiological beneficial effects from both cardiac and peripheral microcirculatory points of view. The loss or reversal of stiffness gradient leads to the transmission of a highly pulsatile pressure wave into the microcirculation. This suggests that a higher degree of stiffness of medium-sized conduit arteries may play a role in protecting the microcirculation from a highly pulsatile forward pressure wave. Using the ratio of carotid-femoral pulse wave velocity (PWV) to carotid-radial PWV, referred to as PWV ratio, a recent study in a dialysis cohort has shown that the PWV ratio is a better predictor of mortality than the classical carotid-femoral PWV. Key Messages Theoretically, the use of the PWV ratio seems more logical for risk determination than aortic stiffness as it provides a better estimation of the loss of stiffness gradient, which is the unifying hypothesis that explains the impact of aortic stiffness both on the myocardium and on peripheral organs. PMID:27195235

  1. Painlevé analysis, auto-Bäcklund transformation and new analytic solutions for a generalized variable-coefficient Korteweg-de Vries (KdV) equation

    NASA Astrophysics Data System (ADS)

    Wei, Guang-Mei; Gao, Yi-Tian; Hu, Wei; Zhang, Chun-Yi

    2006-10-01

    There has been considerable interest in the study on the variable-coefficient nonlinear evolution equations in recent years, since they can describe the real situations in many fields of physical and engineering sciences. In this paper, a generalized variable-coefficient KdV (GvcKdV) equation with the external-force and perturbed/dissipative terms is investigated, which can describe the various real situations, including large-amplitude internal waves, blood vessels, Bose-Einstein condensates, rods and positons. The Painlevé analysis leads to the explicit constraint on the variable coefficients for such a equation to pass the Painlevé test. An auto-Bäcklund transformation is provided by use of the truncated Painlevé expansion and symbolic computation. Via the given auto-Bäcklund transformation, three families of analytic solutions are obtained, including the solitonic and periodic solutions.

  2. Bright optical solitons or light bullets for a (3 + 1)-dimensional generalized nonlinear Schrödinger equation with the distributed coefficients

    NASA Astrophysics Data System (ADS)

    Yin, Hui-Min; Tian, Bo; Zhen, Hui-Ling; Chai, Jun; Wu, Xiao-Yu

    2016-09-01

    Under investigation in this paper is a (3 + 1)-dimensional generalized nonlinear Schrödinger equation with the distributed coefficients for the spatiotemporal optical solitons or light bullets. Through the symbolic computation and Hirota method, one- and two-soliton solutions are derived. We also present the Bäcklund transformation, through which we derive the soliton solutions. When the gain/loss coefficient is the monotonically decreasing function for the propagation coordinate z, amplitude for the spatiotemporal optical soliton or light bullet decreases along z, while when the gain/loss coefficient is the monotonically increasing function for z, amplitude for the spatiotemporal optical soliton or light bullet increases along z. Directions of the solitons are different because the signs of imaginary parts of the frequencies are adverse. Based on the two-soliton solutions, elastic and inelastic collisions between the two spatiotemporal optical solitons or light bullets are derived under different conditions presented in the paper.

  3. Transfer having a coupling coefficient higher than its active material

    NASA Technical Reports Server (NTRS)

    Lesieutre, George A. (Inventor); Davis, Christopher L. (Inventor)

    2001-01-01

    A coupling coefficient is a measure of the effectiveness with which a shape-changing material (or a device employing such a material) converts the energy in an imposed signal to useful mechanical energy. Device coupling coefficients are properties of the device and, although related to the material coupling coefficients, are generally different from them. This invention describes a class of devices wherein the apparent coupling coefficient can, in principle, approach 1.0, corresponding to perfect electromechanical energy conversion. The key feature of this class of devices is the use of destabilizing mechanical pre-loads to counter inherent stiffness. The approach is illustrated for piezoelectric and thermoelectrically actuated devices. The invention provides a way to simultaneously increase both displacement and force, distinguishing it from alternatives such as motion amplification, and allows transducer designers to achieve substantial performance gains for actuator and sensor devices.

  4. The generalized correlation for the evaluation of the influence of the Stefan flow on the heat transfer coefficient

    NASA Astrophysics Data System (ADS)

    Baskakov, A. P.; Rakov, O. A.

    2013-11-01

    The analytical equations for the steady-state heat-and-mass transfer in the steam evaporation/condensation processes from the steam-gas mixtures on the planar and spherical surfaces are derived. The vapor flow through the motionless dry gas is considered according to the method proposed by Maxwell for the solution of the diffusion problems. The relationships for the calculation of the coefficients taking into account an increase in the mass output and an increase or a decrease in the heat emission (depending on the directions of the heat-and-mass flows) as a result of the influence of the Stefan flow are presented. The derived relationships can be used to calculate the apparatuses in which the steam evaporation or condensation from the steam-gas mixture occurs (the coolers of the vapor from deaerators, the apparatuses for the deep utilization of the heat of the combustion products, the condensation boilers, etc.).

  5. Hierarchies of plant stiffness.

    PubMed

    Brulé, Veronique; Rafsanjani, Ahmad; Pasini, Damiano; Western, Tamara L

    2016-09-01

    Plants must meet mechanical as well as physiological and reproductive requirements for survival. Management of internal and external stresses is achieved through their unique hierarchical architecture. Stiffness is determined by a combination of morphological (geometrical) and compositional variables that vary across multiple length scales ranging from the whole plant to organ, tissue, cell and cell wall levels. These parameters include, among others, organ diameter, tissue organization, cell size, density and turgor pressure, and the thickness and composition of cell walls. These structural parameters and their consequences on plant stiffness are reviewed in the context of work on stems of the genetic reference plant Arabidopsis thaliana (Arabidopsis), and the suitability of Arabidopsis as a model system for consistent investigation of factors controlling plant stiffness is put forward. Moving beyond Arabidopsis, the presence of morphological parameters causing stiffness gradients across length-scales leads to beneficial emergent properties such as increased load-bearing capacity and reversible actuation. Tailoring of plant stiffness for old and new purposes in agriculture and forestry can be achieved through bioengineering based on the knowledge of the morphological and compositional parameters of plant stiffness in combination with gene identification through the use of genetics.

  6. Hierarchies of plant stiffness.

    PubMed

    Brulé, Veronique; Rafsanjani, Ahmad; Pasini, Damiano; Western, Tamara L

    2016-09-01

    Plants must meet mechanical as well as physiological and reproductive requirements for survival. Management of internal and external stresses is achieved through their unique hierarchical architecture. Stiffness is determined by a combination of morphological (geometrical) and compositional variables that vary across multiple length scales ranging from the whole plant to organ, tissue, cell and cell wall levels. These parameters include, among others, organ diameter, tissue organization, cell size, density and turgor pressure, and the thickness and composition of cell walls. These structural parameters and their consequences on plant stiffness are reviewed in the context of work on stems of the genetic reference plant Arabidopsis thaliana (Arabidopsis), and the suitability of Arabidopsis as a model system for consistent investigation of factors controlling plant stiffness is put forward. Moving beyond Arabidopsis, the presence of morphological parameters causing stiffness gradients across length-scales leads to beneficial emergent properties such as increased load-bearing capacity and reversible actuation. Tailoring of plant stiffness for old and new purposes in agriculture and forestry can be achieved through bioengineering based on the knowledge of the morphological and compositional parameters of plant stiffness in combination with gene identification through the use of genetics. PMID:27457986

  7. Rogue wave solutions for the higher-order nonlinear Schrödinger equation with variable coefficients by generalized Darboux transformation

    NASA Astrophysics Data System (ADS)

    Zhang, Hai-Qiang; Chen, Jian

    2016-04-01

    In this paper, we study a higher-order variable coefficient nonlinear Schrödinger (NLS) equation, which plays an important role in the control of the ultrashort optical pulse propagation in nonlinear optical systems. Then, we construct a generalized Darboux transformation (GDT) for the higher-order variable coefficient NLS equation. The Nth order rogue wave solution is obtained by the iterative rule and it can be expressed by the determinant form. As application, we calculate rogue waves (RWs) from first- to fourth-order in accordance with different kinds of parameters. In particular, the dynamical properties and spatial-temporal structures of RWs are discussed and compared with Hirota equation through some figures.

  8. Variable stiffness materials for reconfigurable surface applications

    NASA Astrophysics Data System (ADS)

    McKnight, Geoff; Henry, Chris

    2005-05-01

    Reconfigurable and morphing structures can potentially provide a range of new functionalities including system optimization over broad operational conditions and multi-mission capability. Previous efforts in morphing surfaces have generally focused on small deformation of high stiffness structural materials (e.g. aluminum, CFRP) or large deformation of low stiffness non-structural materials (e.g. elastomers). This paper introduces a new approach to achieving large strains in materials with high elastic moduli (5 to 30+ GPa). The work centers on creating variable stiffness composite materials which exhibit a controllable change in elastic modulus (bending or axial) and large reversible strains (5-15%). Several prototype materials were prepared using a commercial shape memory polymer, and measurements on these materials indicate a controllable change in stiffness as a function of temperature along with large reversible strain accommodation. We have fabricated and tested several design variations of laminar morphing materials which exhibit structural stiffness values of 8-12 GPa, changes in modulus of 15-77x, and large reversible bending strain and recovery of 2% area change in specific sample types. Results indicate that significant controllable changes in stiffness are possible.

  9. Digital-map grids of mean-annual precipitation for 1961-90, and generalized skew coefficients of annual maximum streamflow for Oklahoma

    USGS Publications Warehouse

    Rea, A.H.; Tortorelli, R.L.

    1997-01-01

    This digital report contains two digital-map grids of data that were used to develop peak-flow regression equations in Tortorelli, 1997, 'Techniques for estimating peak-streamflow frequency for unregulated streams and streams regulated by small floodwater retarding structures in Oklahoma,' U.S. Geological Survey Water-Resources Investigations Report 97-4202. One data set is a grid of mean annual precipitation, in inches, based on the period 1961-90, for Oklahoma. The data set was derived from the PRISM (Parameter-elevation Regressions on Independent Slopes Model) mean annual precipitation grid for the United States, developed by Daly, Neilson, and Phillips (1994, 'A statistical-topographic model for mapping climatological precipitation over mountainous terrain:' Journal of Applied Meteorology, v. 33, no. 2, p. 140-158). The second data set is a grid of generalized skew coefficients of logarithms of annual maximum streamflow for Oklahoma streams less than or equal to 2,510 square miles in drainage area. This grid of skew coefficients is taken from figure 11 of Tortorelli and Bergman, 1985, 'Techniques for estimating flood peak discharges for unregulated streams and streams regulated by small floodwater retarding structures in Oklahoma,' U.S. Geological Survey Water-Resources Investigations Report 84-4358. To save disk space, the skew coefficient values have been multiplied by 100 and rounded to integers with two significant digits. The data sets are provided in an ASCII grid format.

  10. Understanding supported reactions in spherical compartments: a general algorithm to model and determine rate constants, diffusion coefficients, and spatial product distributions.

    PubMed

    Egelhaaf, Hans-Joachim; Rademann, Jörg

    2005-01-01

    A general algorithm allowing the numerical modeling of the time and space dependence of product formation in spherical reaction volumes is described. The algorithm is described by the complete set of mass balance equations. On the basis of these equations, the effects of the diffusion coefficient, reaction rate, bead size, reagent excess, and packing density of the resin beads on the overall reaction rates are determined for second-order reactions. Experimental data of reaction progress are employed to calculate reaction rates and diffusion coefficients in polymer-supported reactions. In addition, the conditions for shell-like product formation are determined, and various strategies for the radial patterning of resin beads are compared. The effect of diffusion on polymer-supported enzyme-catalyzed reactions of the Michaelis-Menten type is treated, as well. Finally, the effects of typical nonideal solid-phase phenomena, namely, the inhomogeneity of rate constants and the concentration dependence of diffusion coefficients, on overall rates are discussed.

  11. Stiff-system problems and solutions at LLNL

    SciTech Connect

    Hindmarsh, A.C.

    1982-03-01

    Difficult stiff system problems encountered at LLNL are typified by those arising from various atmospheric kinetics models, which include reaction kinetics and transport in up to two space dimensions. Approaches devised for these problems resulted in several general purpose stiff system solvers. These have since evolved into a new systematized collection of solvers, called ODEPACK, based on backward differentiation formulas in the stiff case. A model kinetics-transport problem is used to illustrate the various solvers.

  12. Non-axial muscle stress and stiffness.

    PubMed

    Zahalak, G I

    1996-09-01

    A generalization is developed of the classic two-state Huxley cross-bridge model to account for non-axial active stress and stiffness. The main ingredients of the model are: (i) a relation between the general three-dimensional deformation of an element of muscle and the deformations of the cross-bridges, that assumes macroscopic deformation is transmitted to the myofibrils, (ii) radial as well as axial cross-bridge stiffness, and (iii) variations of the attachment and detachment rates with lateral filament spacing. The theory leads to a generalized Huxley rate equation on the bond-distribution function, n(zeta, theta, t), of the form [equation: see text] where the Dij are the components of the relative velocity gradient and rho and ñ are functions of the polar angle, theta, and time that describe, respectively, the deformation of the myofilament lattice and the distribution of accessible actin sites (both of these functions can be calculated from the macroscopic deformation). Explicit expressions, in terms of n, are derived for the nine components of the active stress tensor, and the 21 non-vanishing components of the active stiffness tensor; the active stress tensor is found to be unsymmetric. The theory predicts that in general non-axial deformations will modify active axial stress and stiffness, and also give rise to non-axial (e.g., shearing) components. Under most circumstances the magnitudes of the non-axial stress and stiffness components will be small compared with the axial and, further, the effects of non-axial deformation rates will be small compared with those of the axial rate. Large transverse deformations may, however, greatly reduce the axial force and stiffness. The theory suggests a significant mechanical role for the non-contractile proteins in muscle, namely that of equilibrating the unsymmetric active stresses. Some simple applications of the theory are provided to illustrate its physical content. PMID:8917737

  13. Genetic impact dominates over environmental effects in development of carotid artery stiffness: a twin study.

    PubMed

    Horváth, Tamás; Osztovits, János; Pintér, Alexandra; Littvay, Levente; Cseh, Domonkos; Tárnoki, Adám D; Tárnoki, Dávid L; Jermendy, Adám L; Steinbach, Rita; Métneki, Júlia; Schillaci, Giuseppe; Kollai, Márk; Jermendy, György

    2014-01-01

    Arterial stiffness is an independent predictor of cardiovascular, cerebrovascular and all-cause mortality. Quantifying the genetic influence on the stiff arterial phenotype allows us to better predict the development of arterial stiffness. In this study, we aimed to determine the heritability of carotid artery stiffness in healthy twins. We studied 98 twin pairs of both sexes. We determined carotid artery stiffness locally using echo tracking and applanation tonometry. We estimated the heritability of stiffness parameters using structural equation modeling. The carotid distensibility coefficient showed the highest heritability (64%, 95% confidence interval 45-77%). The incremental elastic modulus, compliance and stiffness index β also showed substantial heritability (62%, 61% and 58%, respectively). The remaining 36-42% phenotypic variance was attributed to unshared environmental effects. Genetic influence appears to dominate over environmental factors in the development of carotid artery stiffness. Environmental factors may have an important role in favorably influencing the genetic predisposition for accelerated arterial stiffening.

  14. Waves in geomaterials exhibiting negative stiffness behaviour

    NASA Astrophysics Data System (ADS)

    Esin, Maxim; Dyskin, Arcady; Pasternak, Elena

    2016-04-01

    Negative stiffness denotes the type of material behaviour when the force applied to the body decreases the body's deformation increases. Some geomaterials, for instance, rocks, demonstrate behaviour of this type at certain loads: during the compression tests the loading curves exhibit descending branch (post-peak softening). One of the possible mechanisms of the negative stiffness appearance in geomaterials is rotation of non-spherical grains. It is important to emphasize that in this case the descending branch may be reversible given that the testing machine is stiff enough (in general case it means an importance of boundary conditions). Existence of geomaterials with a negative modulus associated with rotations may have significant importance. In particular, important is understanding of the wave propagation in such materials. We study the stability of geomaterials with negative stiffness inclusions and wave propagation in it using two approaches: Cosserat continuum and discrete mass-spring models. In both cases we consider the rotational degrees of freedom in addition to the conventional translational ones. We show that despite non positiveness of the energy the materials with negative stiffness elements can be stable if certain conditions are met. In the case of Cosserat continuum the Cosserat shear modulus (the modulus relating the non-symmetrical part of shear stress and internal rotations) is allowed to assume negative values as long as its value does not exceed the value of the standard (positive) shear modulus. In the case of discrete mass-spring systems (with translational and rotational springs) the concentration of negative stiffness springs and the absolute values of negative spring stiffness are limited. The critical concentration when the system loses stability and the amplitude of the oscillations tends to infinity is equal to 1/2 and 3/5 for two- and three-dimensional cases respectively.

  15. Post-traumatic knee stiffness: surgical techniques.

    PubMed

    Pujol, N; Boisrenoult, P; Beaufils, P

    2015-02-01

    Post-traumatic knee stiffness and loss of range of motion is a common complication of injuries to the knee area. The causes of post-traumatic knee stiffness can be divided into flexion contractures, extension contractures, and combined contractures. Post-traumatic stiffness can be due to the presence of dense intra-articular adhesions and/or fibrotic transformation of peri-articular structures. Various open and arthroscopic surgical treatments are possible. A precise diagnosis and understanding of the pathology is mandatory prior to any surgical treatment. Failure is imminent if all pathologies are not addressed correctly. From a general point of view, a flexion contracture is due to posterior adhesions and/or anterior impingement. On the other hand, extension contractures are due to anterior adhesions and/or posterior impingement. This overview will describe the different modern surgical techniques for treating post-traumatic knee stiffness. Any bony impingements must be treated before soft tissue release is performed. Intra-articular stiff knees with a loss of flexion can be treated by an anterior arthroscopic arthrolysis. Extra-articular pathology causing a flexion contracture can be treated by open or endoscopic quadriceps release. Extension contractures can be treated by arthroscopic or open posterior arthrolysis. Postoperative care (analgesia, rehabilitation) is essential to maintaining the range of motion obtained intra-operatively.

  16. On quasi-periodic wave solutions and asymptotic behaviors to a (2 + 1)-dimensional generalized variable-coefficient Sawada-Kotera equation

    NASA Astrophysics Data System (ADS)

    Tu, Jian-Min; Tian, Shou-Fu; Xu, Mei-Juan; Ma, Pan-Li

    2015-07-01

    In this paper, a (2 + 1)-dimensional generalized variable-coefficient Sawada-Kotera (gvcSK) equation is investigated, which describes many nonlinear phenomena in fluid dynamics and plasma physics. Based on the properties of binary Bell polynomials, we present a Hirota’s bilinear equation to the gvcSK equation. By virtue of the Hirota’s bilinear equation, we obtain the N-soliton solutions and the quasi-periodic wave solutions of the gvcSK equation, which can be reduced to the ones of several integrable equations such as Sawada-Kotera, modified Caudrey-Dodd-Gibbon-Sawada-Kotera, isospectral BKP equations and etc. Furthermore, we obtain the relationship between the soliton solutions and periodic solutions by considering the asymptotic properties of the periodic solutions.

  17. Generalized semi-analytical solutions to multispecies transport equation coupled with sequential first-order reaction network with spatially or temporally variable transport and decay coefficients

    NASA Astrophysics Data System (ADS)

    Suk, Heejun

    2016-08-01

    This paper presents a semi-analytical procedure for solving coupled the multispecies reactive solute transport equations, with a sequential first-order reaction network on spatially or temporally varying flow velocities and dispersion coefficients involving distinct retardation factors. This proposed approach was developed to overcome the limitation reported by Suk (2013) regarding the identical retardation values for all reactive species, while maintaining the extensive capability of the previous Suk method involving spatially variable or temporally variable coefficients of transport, general initial conditions, and arbitrary temporal variable inlet concentration. The proposed approach sequentially calculates the concentration distributions of each species by employing only the generalized integral transform technique (GITT). Because the proposed solutions for each species' concentration distributions have separable forms in space and time, the solution for subsequent species (daughter species) can be obtained using only the GITT without the decomposition by change-of-variables method imposing the limitation of identical retardation values for all the reactive species by directly substituting solutions for the preceding species (parent species) into the transport equation of subsequent species (daughter species). The proposed solutions were compared with previously published analytical solutions or numerical solutions of the numerical code of the Two-Dimensional Subsurface Flow, Fate and Transport of Microbes and Chemicals (2DFATMIC) in three verification examples. In these examples, the proposed solutions were well matched with previous analytical solutions and the numerical solutions obtained by 2DFATMIC model. A hypothetical single-well push-pull test example and a scale-dependent dispersion example were designed to demonstrate the practical application of the proposed solution to a real field problem.

  18. Properties of the grasp stiffness matrix and conservative control strategies

    SciTech Connect

    Kao, I.; Ngo, C.

    1999-02-01

    In this paper, the authors present fundamental properties of stiffness matrices as applied in analysis of grasping and dexterous manipulation in configuration spaces and linear Euclidean R{sup 3x3} space without rotational components. A conservative-stiffness matrix in such spaces needs to satisfy both symmetric and exact differential criteria. Two types of stiffness matrices are discussed: constant and configuration-dependent matrices are discussed: constant and configuration-dependent matrices. The symmetric part of a constant-stiffness matrix can be derived from a conservative quadratic potential function in the Hermitian form; while the skew-symmetric part is a function of the nonconservative curl vector field of the grasp. A configuration-dependent stiffness matrix needs to be symmetric and must simultaneously satisfy the exact differential condition to be conservative. The theory is most relevant to the Cartesian stiffness control, where the stiffness of the end effector is usually constant, such as that in RCC wrists. Conservative control strategies are proposed for a configuration-dependent stiffness matrix. One of the most important results of this paper is the nonconservative congruence mapping of stiffness between the joint and Cartesian spaces. In general, the congruence transformation (or its inverse transformation), K{sub {theta}} = J{sub {theta}}{sup T}K{sub p}J{sub {theta}}, is a nonconservative mapping over finite paths for a configuration-dependent Jacobian. Thus, to obtain a conservative system with respect to the Cartesian space, one has to either find the corresponding K{sub {theta}} at every configuration due to the constant and symmetric Cartesian stiffness matrix, or determine symmetric yet configuration-varying K{sub {theta}} at every configuration due to the constant and symmetric Cartesian stiffness matrix, or determine the symmetric yet configuration-varying K{sub {theta}} which makes the resulting configuration-dependent K{sub p

  19. Longitudinal diffusion coefficients and test of the generalized Einstein relation for Tl + ions in Kr and Xe, Li + in Kr and Xe, and Cl - in N2 a)

    NASA Astrophysics Data System (ADS)

    Thackston, M. G.; Byers, M. S.; Holleman, F. B.; Chelf, R. D.; Twist, J. R.; McDaniel, E. W.

    1983-04-01

    Longitudinal diffusion coefficients are measured for Tl+ in Kr and Xe, Li+ in Kr and Xe and cl- in N2. These diffusion coefficients are compared with the calculated ones from a previous measurement of ion mobility values.3 (AIP)

  20. Dynamically variable negative stiffness structures.

    PubMed

    Churchill, Christopher B; Shahan, David W; Smith, Sloan P; Keefe, Andrew C; McKnight, Geoffrey P

    2016-02-01

    Variable stiffness structures that enable a wide range of efficient load-bearing and dexterous activity are ubiquitous in mammalian musculoskeletal systems but are rare in engineered systems because of their complexity, power, and cost. We present a new negative stiffness-based load-bearing structure with dynamically tunable stiffness. Negative stiffness, traditionally used to achieve novel response from passive structures, is a powerful tool to achieve dynamic stiffness changes when configured with an active component. Using relatively simple hardware and low-power, low-frequency actuation, we show an assembly capable of fast (<10 ms) and useful (>100×) dynamic stiffness control. This approach mitigates limitations of conventional tunable stiffness structures that exhibit either small (<30%) stiffness change, high friction, poor load/torque transmission at low stiffness, or high power active control at the frequencies of interest. We experimentally demonstrate actively tunable vibration isolation and stiffness tuning independent of supported loads, enhancing applications such as humanoid robotic limbs and lightweight adaptive vibration isolators. PMID:26989771

  1. A generalized theory for eccentric and misalignment effects in high-pressure annular seals

    NASA Technical Reports Server (NTRS)

    Chen, W. C.; Jackson, E. D.

    1986-01-01

    High-pressure annular seal leakage and dynamic coefficients vary with eccentricity and misalignment. Recent seal leakage data with both concentric and fully eccentric alignments support the seal leakage model with surface roughness and eccentricity effects included. In this paper, the seal dynamic coefficient calculation has been generalized and allows direct calculation of the seal dynamic coefficients at any circumferential location. The generalized solution agrees with the results obtained by using the calculated values of an earlier paper and performing a coordinate transformation. The analysis results coincide with the measured data in showing that the stiffness and damping matrices of seal coefficients are not skew symmetric, and the main diagonal seal coefficients are not equal. The measured direct stiffnesses were found higher than predicted by the concentric seal theory, but this may be explained by the presence of eccentricity in the test operating mode.

  2. Stiffness, thermal expansion, and thermal bending formulation of stiffened, fiber-reinforced composite panels

    NASA Astrophysics Data System (ADS)

    Collier, Craig S.

    1993-04-01

    A method is presented for formulating stiffness terms and thermal coefficients of stiffened, fiber-reinforced composite panels. The method is robust enough to handle panels with general cross sectional shapes, including those which are unsymmetric and/or unbalanced. Nonlinear, temperature and load dependent constitutive material data of each laminate are used to 'build-up' the stiffened panel membrane, bending, and membrane-bending coupling stiffness terms and thermal coefficients. New thermal coefficients are introduced to quantify panel response from through-the-thickness temperature gradients. A technique of implementing this capability with a single plane of shell finite elements using the MSC/NASTRAN analysis program (FEA) is revealed that provides accurate solutions of entire airframes or engines with coarsely meshed models. An example of a composite, hat-stiffened panel is included to demonstrate errors that occur when an unsymmetric panel is symmetrically formulated as traditionally done. The erroneous results and the correct ones produced from this method are compared to analysis from discretely meshed three-dimensional FEA.

  3. Stiffness, thermal expansion, and thermal bending formulation of stiffened, fiber-reinforced composite panels

    NASA Technical Reports Server (NTRS)

    Collier, Craig S.

    1993-01-01

    A method is presented for formulating stiffness terms and thermal coefficients of stiffened, fiber-reinforced composite panels. The method is robust enough to handle panels with general cross sectional shapes, including those which are unsymmetric and/or unbalanced. Nonlinear, temperature and load dependent constitutive material data of each laminate are used to 'build-up' the stiffened panel membrane, bending, and membrane-bending coupling stiffness terms and thermal coefficients. New thermal coefficients are introduced to quantify panel response from through-the-thickness temperature gradients. A technique of implementing this capability with a single plane of shell finite elements using the MSC/NASTRAN analysis program (FEA) is revealed that provides accurate solutions of entire airframes or engines with coarsely meshed models. An example of a composite, hat-stiffened panel is included to demonstrate errors that occur when an unsymmetric panel is symmetrically formulated as traditionally done. The erroneous results and the correct ones produced from this method are compared to analysis from discretely meshed three-dimensional FEA.

  4. Dynamically variable negative stiffness structures

    PubMed Central

    Churchill, Christopher B.; Shahan, David W.; Smith, Sloan P.; Keefe, Andrew C.; McKnight, Geoffrey P.

    2016-01-01

    Variable stiffness structures that enable a wide range of efficient load-bearing and dexterous activity are ubiquitous in mammalian musculoskeletal systems but are rare in engineered systems because of their complexity, power, and cost. We present a new negative stiffness–based load-bearing structure with dynamically tunable stiffness. Negative stiffness, traditionally used to achieve novel response from passive structures, is a powerful tool to achieve dynamic stiffness changes when configured with an active component. Using relatively simple hardware and low-power, low-frequency actuation, we show an assembly capable of fast (<10 ms) and useful (>100×) dynamic stiffness control. This approach mitigates limitations of conventional tunable stiffness structures that exhibit either small (<30%) stiffness change, high friction, poor load/torque transmission at low stiffness, or high power active control at the frequencies of interest. We experimentally demonstrate actively tunable vibration isolation and stiffness tuning independent of supported loads, enhancing applications such as humanoid robotic limbs and lightweight adaptive vibration isolators. PMID:26989771

  5. Arterial Stiffness and Chronic Kidney Disease

    PubMed Central

    Garnier, Anne-Sophie; Briet, Marie

    2016-01-01

    Chronic kidney disease (CKD) is a major public health concern due to the high prevalence of associated cardiovascular (CV) disease. CV mortality is 10-30 times higher in end-stage renal disease patients than in the age-adjusted general population. The last 20 years have been marked by a huge effort in the characterization of the vascular remodeling process associated with CKD and its consequences on the renal, CV and general prognosis. By comparison with patients with normal renal function, with or without hypertension, an increase in large artery stiffness has been described in end-stage renal disease as well as in CKD stages 2-5. Most clinical studies are consistent with the observation that damage to large arteries may contribute to the high incidence of CV disease. By contrast, the impact of large artery stiffening and remodeling on CKD progression is still a matter of debate. Concomitant exposure to other CV risk factors, including diabetes, seems to play a major role in the association between aortic stiffness and estimated GFR. The conflicting results obtained from longitudinal studies designed to evaluate the impact of baseline aortic stiffness on GFR progression are detailed in the present review. Only pulse pressure, central and peripheral, is almost constantly associated with incident CKD and GFR decline. Kidney transplantation improves patients’ CV prognosis, but its impact on arterial stiffness is still controversial. Donor age, living kidney donation and mean blood pressure appear to be the main determinants of improvement in aortic stiffness after kidney transplantation. PMID:27195244

  6. Theory versus experiment for the rotordynamic coefficients of annular gas seals. Part 2: Constant clearance and convergent-tapered geometry

    NASA Technical Reports Server (NTRS)

    Nelson, C. C.; Childs, D. W.; Nicks, C.; Elrod, D.

    1985-01-01

    The leakage and rotordynamic coefficients of constant-clearance and convergent-tapered annular gas seals were measured in an experimental test facility. The results are presented along with the theoretically predicted values. Of particular interest is the prediction that optimally tapered seals have significantly larger direct siffness than straight seals. The experimental results verify this prediction. Generally the theory does quite well, but fails to predict the large increase in direct stiffness when the fluid is pre-rotated.

  7. Hormones and arterial stiffness in patients with chronic kidney disease.

    PubMed

    Gungor, Ozkan; Kircelli, Fatih; Voroneanu, Luminita; Covic, Adrian; Ok, Ercan

    2013-01-01

    Cardiovascular disease constitutes the major cause of mortality in patients with chronic kidney disease. Arterial stiffness is an important contributor to the occurrence and progression of cardiovascular disease. Various risk factors, including altered hormone levels, have been suggested to be associated with arterial stiffness. Based on the background that chronic kidney disease predisposes individuals to a wide range of hormonal changes, we herein review the available data on the association between arterial stiffness and hormones in patients with chronic kidney disease and summarize the data for the general population.

  8. Nonlinear vibration of thick stiff fabric with small flexural stiffness

    NASA Astrophysics Data System (ADS)

    Chen, J.-P.; Wang, S.-Z.; Wu, W.-Y.; Gu, H.-B.

    2008-02-01

    Dynamic behaviour of fabric is very complex during weaving, dyeing and finishing processes. Thick stiff fabric vibration has great influence not only on the fabric itself but also on the performance of machine. The theoretic analysis for the nonlinear free vibration of thick stiff fabric with small flexural stiffness is put forward in the paper. The nonlinear partial differential equation is derived by applying the flexible thin plate theory, and then transformed into nonlinear ordinary differential equation by the Galerkin method. The approximate analytical solution is obtained by the homotopy perturbation method.

  9. Hyperekplexia and stiff-baby syndrome: an identical neurological disorder?

    PubMed

    Cioni, G; Biagioni, E; Bottai, P; Castellacci, A M; Paolicelli, P B

    1993-03-01

    Hyperekplexia (startle disease) is an unusual, familial, neurological disorder characterized by abnormally enhanced startle response, followed in most cases by momentary generalized muscular stiffness. These attacks may cause the patients to fall rigidly, while remaining fully conscious. Startle symptomatology has generally an onset in infancy and is often accompanied, during the first years of life, by rigidity, sleep myoclonus, motor delay, regurgitation and apneic spells, which may cause sudden death. Stiff-baby syndrome is a familial disorder characterized by marked rigidity, with neonatal onset and gradual reduction during infancy, regurgitations, motor delay and attacks of stiffness. We report 4 new cases of hyperekplexia from two different families and another infant with stiff-baby syndrome discussing clinical, electrophysiological and genetic aspects of both neurological disorders in relation to other reported cases. We suggest a continuum between these familial syndromes, which are often misinterpreted as epilepsy or other disorders.

  10. Time simulation of flutter with large stiffness changes

    NASA Technical Reports Server (NTRS)

    Karpel, Mordechay; Wieseman, Carol D.

    1992-01-01

    Time simulation of flutter, involving large local structural changes, is formulated with a state-space model that is based on a relatively small number of generalized coordinates. Free-free vibration modes are first calculated for a nominal finite-element model with relatively large fictitious masses located at the area of structural changes. A low-frequency subset of these modes is then transformed into a set of structural modal coordinates with which the entire simulation is performed. These generalized coordinates and the associated oscillatory aerodynamic force coefficient matrices are used to construct an efficient time-domain, state-space model for a basic aeroelastic case. The time simulation can then be performed by simply changing the mass, stiffness, and damping coupling terms when structural changes occur. It is shown that the size of the aeroelastic model required for time simulation with large structural changes at a few apriori known locations is similar to that required for direct analysis of a single structural case. The method is applied to the simulation of an aeroelastic wind-tunnel model. The diverging oscillations are followed by the activation of a tip-ballast decoupling mechanism that stabilizes the system but may cause significant transient overshoots.

  11. Measuring Age-Dependent Myocardial Stiffness across the Cardiac Cycle using MR Elastography: A Reproducibility Study

    PubMed Central

    Wassenaar, Peter A; Eleswarpu, Chethanya N; Schroeder, Samuel A; Mo, Xiaokui; Raterman, Brian D; White, Richard D; Kolipaka, Arunark

    2015-01-01

    Purpose To assess reproducibility in measuring left ventricular (LV) myocardial stiffness in volunteers throughout the cardiac cycle using magnetic resonance elastography (MRE) and to determine its correlation with age. Methods Cardiac MRE (CMRE) was performed on 29 normal volunteers, with ages ranging from 21 to 73 years. For assessing reproducibility of CMRE-derived stiffness measurements, scans were repeated per volunteer. Wave images were acquired throughout the LV myocardium, and were analyzed to obtain mean stiffness during the cardiac cycle. CMRE-derived stiffness values were correlated to age. Results Concordance correlation coefficient revealed good inter-scan agreement with rc of 0.77, with p-value<0.0001. Significantly higher myocardial stiffness was observed during end-systole (ES) compared to end-diastole (ED) across all subjects. Additionally, increased deviation between ES and ED stiffness was observed with increased age. Conclusion CMRE-derived stiffness is reproducible, with myocardial stiffness changing cyclically across the cardiac cycle. Stiffness is significantly higher during ES compared to ED. With age, ES myocardial stiffness increases more than ED, giving rise to an increased deviation between the two. PMID:26010456

  12. Stiffness and damping of elastomeric O-ring bearing mounts

    NASA Technical Reports Server (NTRS)

    Smalley, A. J.

    1977-01-01

    A test rig to measure the dynamic stiffness and damping of elastomer O rings was described. Test results for stiffness and loss coefficient in the frequency range from 50 Hz to 1000 Hz are presented. Results are given for three different materials, for five temperatures, for three amplitudes, for five values of squeeze for three values of stretch for three values of cross-section diameter and for three values of groove width. All test data points were plotted. In addition, trend summary plots were presented which compare the effect of material, temperature, amplitude, squeeze, stretch, cross-section diameter, and groove width. O ring deflections under a static load for different material were presented; and effective static stiffness values were compared with dynamic values.

  13. Assessment of the stiffness tensor of orthotropic materials from phase velocities measured by means of a line source-point receiver laser-ultrasonic method

    NASA Astrophysics Data System (ADS)

    Audoin, B.; Reverdy, F.

    1999-12-01

    The laser ultrasonic technique is used to generate and detect ultrasonic waves in a composite specimen. When the laser beam is focused by means of a cylindrical lens, the line-source generates transient divergent waves that propagate at group velocity. The phase and group velocities of acoustic waves in elastically anisotropic solids are in general not equal. Anisotropy gives rise to folded ray curves in which the acoustic rays are more concentrated in some directions than in others. In particular the energy density can be very high at the cuspidal edges. The propagation in such media gives rise to internal diffraction by which waves are observed which are not explained by ray theory. The measurement of the stiffness tensor of an anisotropic material by means of laser generated ultrasound is a non trivial matter for essentially two reasons. First, the recovering of the coefficients from the group velocities is a double iterative numerical process that requires a high accuracy in the velocity measurement. Second, internal diffraction is not taken into account by such an algorithm and it provides undesired velocity data which induce a shift of the identified stiffness coefficients. In this paper, it is shown that phase velocities can be measured using signals generated by a line source. The measurement of the stiffness coefficients from such velocities avoids the aforementioned difficulties. The process is successfully applied to an actual composite material.

  14. The interday reliability of ankle, knee, leg, and vertical musculoskeletal stiffness during hopping and overground running.

    PubMed

    Joseph, Corey W; Bradshaw, Elizabeth J; Kemp, Justin; Clark, Ross A

    2013-08-01

    A number of methods are used to measure lower extremity musculoskeletal stiffness, but there is a paucity of research examining the reliability of these techniques. Therefore, we investigated the reliability of vertical, leg, knee, and ankle stiffness during overground running and hopping in 20 active men. Participants were required to run on a 10 m overground runway at 3.83 m/s (actual; 3.35 ± 0.12 m/s) and to hop in place at 2.2 Hz (actual; 2.37 ± 0.03 Hz), and at a self-selected frequency (actual; 2.05 ± 0.12 Hz) and at 2.2 Hz (actual; 2.39 ± 0.04 Hz). Reliability was determined using the intraclass correlation coefficient, coefficient of variation, mean differences, and Cohen's effect sizes. There was good reliability for vertical stiffness, moderate reliability for leg stiffness, and poor reliability for knee and ankle stiffness during the running task. Similar results were observed during the 2.2 Hz hopping tasks, with good reliability displayed for vertical stiffness and poor reliability for ankle and knee stiffness. In conclusion, our results suggest that vertical stiffness is a reliable measure when running at 3.83 m/s and hopping at 2.2 Hz.

  15. Stiffness after total knee arthroplasty.

    PubMed

    Manrique, Jorge; Gomez, Miguel M; Parvizi, Javad

    2015-04-01

    Stiffness after total knee arthroplasty (TKA) adversely affects outcome and impacts patient function. Various risk factors for stiffness after TKA have been identified, including reduced preoperative knee range of motion, history of prior knee surgery, etiology of arthritis, incorrect positioning or oversizing of components, and incorrect gap balancing. Mechanical and associated causes, such as infection, arthrofibrosis, complex regional pain syndrome, and heterotopic ossification, secondary gain issues have also been identified. Management of stiffness following TKA can be challenging. The condition needs to be assessed and treated in a staged manner. A nonsurgical approach is the first step. Manipulation under anesthesia may be considered within the first 3 months after the index TKA, if physical therapy fails to improve the range of motion. Beyond this point, consideration should be given to surgical intervention such as lysis of adhesions, either arthroscopically or by open arthrotomy. If the cause of stiffness is deemed to be surgical error, such as component malpositioning, revision arthroplasty is indicated. The purpose of this article is to evaluate the various aspects of management of stiffness after TKA.

  16. Plyometric training effects on Achilles tendon stiffness and dissipative properties.

    PubMed

    Fouré, Alexandre; Nordez, Antoine; Cornu, Christophe

    2010-09-01

    The aim of this study was to determine the effects of 14 wk of plyometric training on mechanical properties of the Achilles tendon. Nineteen subjects were randomly assigned to trained or control group. Cross-sectional area (CSA), stiffness, and dissipation coefficient of the Achilles tendon were measured before and after the training period. In the trained group, a decrease in dissipation coefficient (-35.0%; P<0.05) and an upward trend in stiffness (+24.1%) of the Achilles tendon was found, without any changes in Achilles tendon CSA (P>0.05). Plyometric training enhances the muscular tension transmission mainly through a reduction in energy dissipated by the tendon. The lack of changes in the Achilles tendon CSA indicates that changes in mechanical properties would mainly result from a qualitative change in tendinous tissues rather than from changes in the geometry of the Achilles tendon.

  17. Positive Association Between Adipose Tissue and Bone Stiffness.

    PubMed

    Berg, R M; Wallaschofski, H; Nauck, M; Rettig, R; Markus, M R P; Laqua, R; Friedrich, N; Hannemann, A

    2015-07-01

    Obesity is often considered to have a protective effect against osteoporosis. On the other hand, several recent studies suggest that adipose tissue may have detrimental effects on bone quality. We therefore aimed to investigate the associations between body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) or abdominal subcutaneous adipose tissue (SAT), and bone stiffness. The study involved 2685 German adults aged 20-79 years, who participated in either the second follow-up of the population-based Study of Health in Pomerania (SHIP-2) or the baseline examination of the SHIP-Trend cohort. VAT and abdominal SAT were quantified by magnetic resonance imaging. Bone stiffness was assessed by quantitative ultrasound (QUS) at the heel (Achilles InSight, GE Healthcare). The individual risk for osteoporotic fractures was determined based on the QUS-derived stiffness index and classified in low, medium, and high risk. Linear regression models, adjusted for sex, age, physical activity, smoking status, risky alcohol consumption, diabetes, and height (in models with VAT or abdominal SAT as exposure), revealed positive associations between BMI, WC, VAT or abdominal SAT, and the QUS variables broadband-ultrasound attenuation or stiffness index. Moreover, BMI was positively associated with speed of sound. Our study shows that all anthropometric measures including BMI and, WC as well as abdominal fat volume are positively associated with bone stiffness in the general population. As potential predictors of bone stiffness, VAT and abdominal SAT are not superior to easily available measures like BMI or WC.

  18. ARTHROSCOPIC TREATMENT OF ELBOW STIFFNESS

    PubMed Central

    Vieira, Luis Alfredo Gómez; Dal Molin, Fabio Farina; Visco, Adalberto; Fernandes, Luis Filipe Daneu; dos Santos, Murilo Cunha Rafael; Cardozo Filho, Nivaldo Souza; Gómez Cordero, Nicolas Gerardo

    2015-01-01

    To present the arthroscopic surgical technique and the evaluation of the results from this technique for treating elbow stiffness. Methods: Between April 2007 and January 2010, ten elbows of ten patients with elbow stiffness underwent arthroscopic treatment to release the range of motion. The minimum follow-up was 11 months, with an average of 27 months. All the patients were male and their average age was 32.8 years (ranging from 22 to 48 years). After the arthroscopic treatment, they were followed up weekly in the first month and every three months thereafter. The clinical evaluation was made using the criteria of the University of California at Los Angeles (UCLA). Results: All the patients were satisfied with the results from the arthroscopic treatment. The average UCLA score was 33.8 points. Conclusion: Arthroscopic treatment for elbow stiffness is a minimally invasive surgical technique that was shown to be efficient for treating this complication. PMID:27027027

  19. Cosmology with a stiff matter era

    NASA Astrophysics Data System (ADS)

    Chavanis, Pierre-Henri

    2015-11-01

    We consider the possibility that the Universe is made of a dark fluid described by a quadratic equation of state P =K ρ2 , where ρ is the rest-mass density and K is a constant. The energy density ɛ =ρ c2+K ρ2 is the sum of two terms: a rest-mass term ρ c2 that mimics "dark matter" (P =0 ) and an internal energy term u =K ρ2=P that mimics a "stiff fluid" (P =ɛ ) in which the speed of sound is equal to the speed of light. In the early universe, the internal energy dominates and the dark fluid behaves as a stiff fluid (P ˜ɛ , ɛ ∝a-6). In the late universe, the rest-mass energy dominates and the dark fluid behaves as pressureless dark matter (P ≃0 , ɛ ∝a-3). We provide a simple analytical solution of the Friedmann equations for a universe undergoing a stiff matter era, a dark matter era, and a dark energy era due to the cosmological constant. This analytical solution generalizes the Einstein-de Sitter solution describing the dark matter era, and the Λ CDM model describing the dark matter era and the dark energy era. Historically, the possibility of a primordial stiff matter era first appeared in the cosmological model of Zel'dovich where the primordial universe is assumed to be made of a cold gas of baryons. A primordial stiff matter era also occurs in recent cosmological models where dark matter is made of relativistic self-gravitating Bose-Einstein condensates (BECs). When the internal energy of the dark fluid mimicking stiff matter is positive, the primordial universe is singular like in the standard big bang theory. It expands from an initial state with a vanishing scale factor and an infinite density. We consider the possibility that the internal energy of the dark fluid is negative (while, of course, its total energy density is positive), so that it mimics anti-stiff matter. This happens, for example, when the BECs have an attractive self-interaction with a negative scattering length. In that case, the primordial universe is nonsingular and

  20. Lase Ultrasonic Web Stiffness tester

    SciTech Connect

    Tim Patterson, Ph.D., IPST at Ga Tech

    2009-01-12

    The objective is to provide a sensor that uses non-contact, laser ultrasonics to measure the stiffness of paper during the manufacturing process. This will allow the manufacturer to adjust the production process in real time, increase filler content, modify fiber refining and as result produce a quality product using less energy. The sensor operates by moving back and forth across the paper web, at pre-selected locations firing a laser at the sheet, measuring the out-of-plane velocity of the sheet then using that measurement to calculate sheet stiffness.

  1. Arterial Stiffness and Cardiovascular Therapy

    PubMed Central

    Janić, Miodrag; Lunder, Mojca; Šabovič, Mišo

    2014-01-01

    The world population is aging and the number of old people is continuously increasing. Arterial structure and function change with age, progressively leading to arterial stiffening. Arterial stiffness is best characterized by measurement of pulse wave velocity (PWV), which is its surrogate marker. It has been shown that PWV could improve cardiovascular event prediction in models that included standard risk factors. Consequently, it might therefore enable better identification of populations at high-risk of cardiovascular morbidity and mortality. The present review is focused on a survey of different pharmacological therapeutic options for decreasing arterial stiffness. The influence of several groups of drugs is described: antihypertensive drugs (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, diuretics, and nitrates), statins, peroral antidiabetics, advanced glycation end-products (AGE) cross-link breakers, anti-inflammatory drugs, endothelin-A receptor antagonists, and vasopeptidase inhibitors. All of these have shown some effect in decreasing arterial stiffness. Nevertheless, further studies are needed which should address the influence of arterial stiffness diminishment on major adverse cardiovascular and cerebrovascular events (MACCE). PMID:25170513

  2. Stiffness matrix method with improved efficiency for elastic wave propagation in layered anisotropic media

    NASA Astrophysics Data System (ADS)

    Tan, Eng Leong

    2005-12-01

    This paper presents the recursive algorithm of stiffness matrix method with improved efficiency for computing the total and surface stiffness matrices for a general multilayered anisotropic media. Based on the eigensolutions commonly available for analysis of such media, the recursive algorithm deals with eigen-submatrices directly and bypasses all intermediate layer stiffness submatrices. The improved algorithm obviates the need to compute certain inverse of the original scheme and makes the stiffness matrix recursion more robust. In situation where transfer matrix is numerically stable and easily accessible, an improved recursive algorithm is also given directly in terms of transfer submatrices without involving their explicit inverse.

  3. Simple Formulas and Results for Buckling-Resistance and Stiffness Design of Compression-Loaded Laminated-Composite Cylinders

    NASA Technical Reports Server (NTRS)

    Nemeth, Michael P.; Mikulas, Martin M., Jr.

    2009-01-01

    Simple formulas for the buckling stress of homogeneous, specially orthotropic, laminated-composite cylinders are presented. The formulas are obtained by using nondimensional parameters and equations that facilitate general validation, and are validated against the exact solution for a wide range of cylinder geometries and laminate constructions. Results are presented that establish the ranges of the nondimensional parameters and coefficients used. General results, given in terms of the nondimensional parameters, are presented that encompass a wide range of geometries and laminate constructions. These general results also illustrate a wide spectrum of behavioral trends. Design-oriented results are also presented that provide a simple, clear indication of laminate composition on critical stress, critical strain, and axial stiffness. An example is provided to demonstrate the application of these results to thin-walled column designs.

  4. Experimental study of the Biot coefficient of Bakken cores

    NASA Astrophysics Data System (ADS)

    Ma, X.; Zoback, M. D.

    2015-12-01

    We have performed a series of exhaustive experiments to measure the Biot coefficient (α) of the tight cores from the Bakken shale oil play. Five distinct, bedding-normal cores from a vertical well were tested, covering the sequences of Three Forks, Lower, Middle, and Upper Bakken, and Lodgepole. The scope of this laboratory study is two-fold: (1) to obtain realistic Biot coefficient for modeling reservoir stress changes due to depletion and injection; (2) to characterize the poromechanical properties in relation to rock's mineral composition and microstructure. The experiments were carried out as follows: Argon-saturated specimen (1-inch length, 1-inch diameter) was subjected to hydrostatic confining pressure under drained conditions. Pore pressure was regulated as Argon was injected into both ends of the specimen. We drilled multiple non-through-going boreholes (1-mm diameter) in the specimen to facilitate pressure equilibrium, without compromising its integrity. The specimen was put through a loading path to experience confining pressure and pore pressure up to 70 and 60 MPa, respectively. Axial and lateral strains were recorded and used to calculate the rock's bulk stiffness, and subsequently the static Biot coefficient, which is related to reservoir deformation and associated stress changes. Results of all five cores unanimously show that α is less than unity and is a function of both confining and pore pressure. α generally varies between 0.3 and 0.9 for the pressure levels we applied. This implies that models of reservoir deformation and its stress change using Terzaghi's simple effective stress law (α = 1) or a constant α less than 1 may be erroneous. Typically, α rises significantly with pore pressure, but declines with confining pressure to the degree that is dependent on rock's bulk stiffness. We found the stiffness of these rocks does not correlate well with the content of compliant components (e.g., clay and kerogen), and the drastic difference in

  5. The correlation between mineralization degree and bone tissue stiffness in the porcine mandibular condyle.

    PubMed

    Willems, Nop M B K; Mulder, Lars; den Toonder, Jaap M J; Zentner, Andrej; Langenbach, Geerling E J

    2014-01-01

    The aim of this study was to correlate the local tissue mineral density (TMD) with the bone tissue stiffness. It was hypothesized that these variables are positively correlated. Cancellous and cortical bone samples were derived from ten mandibular condyles taken from 5 young and 5 adult female pigs. The bone tissue stiffness was assessed in three directions using nanoindentation. At each of three tested sides 5 indents were made over the width of 5 single bone elements, resulting in a total number of 1500 indents. MicroCT was used to determine the local TMD at the indented sites. The TMD and the bone tissue stiffness were higher in bone from the adult animals than from the young ones, but did not differ between cancellous and cortical bone. In the adult group, both the TMD and the bone tissue stiffness were higher in the center than at the surface of the bone elements. The mean TMD, thus ignoring the local mineral distribution, had a coefficient of determination (R(2)) with the mean bone tissue stiffness of 0.55, p < 0.05, whereas the correlation between local bone tissue stiffness and the concomitant TMD appeared to be weak (R (2) 0.07, p < 0.001). It was concluded that the mineralization degree plays a larger role in bone tissue stiffness in cancellous than in cortical bone. Our data based on bone from the mandibular condyle suggest that the mineralization degree is not a decisive determinant of the local bone tissue stiffness.

  6. Stiffness matrix formulation for double row angular contact ball bearings: Analytical development and validation

    NASA Astrophysics Data System (ADS)

    Gunduz, Aydin; Singh, Rajendra

    2013-10-01

    Though double row angular contact ball bearings are widely used in industrial, automotive, and aircraft applications, the scientific literature on double row bearings is sparse. It is also shown that the stiffness matrices of two single row bearings may not be simply superposed to obtain the stiffness matrix of a double row bearing. To overcome the deficiency in the literature, a new, comprehensive, analytical approach is proposed based on the Hertzian theory for back-to-back, face-to-face, and tandem arrangements. The elements of the five-dimensional stiffness matrix for double row angular contact ball bearings are computed given either the mean bearing displacement or the mean load vector. The diagonal elements of the proposed stiffness matrix are verified with a commercial code for all arrangements under three loading scenarios. Some changes in stiffness coefficients are investigated by varying critical kinematic and geometric parameters to provide more insight. Finally, the calculated natural frequencies of a shaft-bearing experiment are successfully compared with measurements, thus validating the proposed stiffness formulation. For double row angular contact ball bearings, the moment stiffness and cross-coupling stiffness terms are significant, and the contact angle changes under loads. The proposed formulation is also valid for paired (duplex) bearings which behave as an integrated double row unit when the surrounding structural elements are sufficiently rigid.

  7. Study of the determination of the coefficients beta and gamma of the generalized metric of Robertson and of the dynamical oblateness of the sun

    NASA Technical Reports Server (NTRS)

    Marchal, C.

    1971-01-01

    Motion of a space probe about a spherical center of attraction is considered, applying the general theory of relativity. Motion of a probe under the influence of the sun's oblateness is also discussed. Estimates of beta, gamma, and J20 using solar probe motion are presented. It is concluded that such measurements are possible if the unknown long-period perturbing acceleration is of the order of 10 to the -11th or -12th power m/sec. sq.

  8. Graph characterization via Ihara coefficients.

    PubMed

    Ren, Peng; Wilson, Richard C; Hancock, Edwin R

    2011-02-01

    The novel contributions of this paper are twofold. First, we demonstrate how to characterize unweighted graphs in a permutation-invariant manner using the polynomial coefficients from the Ihara zeta function, i.e., the Ihara coefficients. Second, we generalize the definition of the Ihara coefficients to edge-weighted graphs. For an unweighted graph, the Ihara zeta function is the reciprocal of a quasi characteristic polynomial of the adjacency matrix of the associated oriented line graph. Since the Ihara zeta function has poles that give rise to infinities, the most convenient numerically stable representation is to work with the coefficients of the quasi characteristic polynomial. Moreover, the polynomial coefficients are invariant to vertex order permutations and also convey information concerning the cycle structure of the graph. To generalize the representation to edge-weighted graphs, we make use of the reduced Bartholdi zeta function. We prove that the computation of the Ihara coefficients for unweighted graphs is a special case of our proposed method for unit edge weights. We also present a spectral analysis of the Ihara coefficients and indicate their advantages over other graph spectral methods. We apply the proposed graph characterization method to capturing graph-class structure and clustering graphs. Experimental results reveal that the Ihara coefficients are more effective than methods based on Laplacian spectra.

  9. Elastic metamaterial beam with remotely tunable stiffness

    NASA Astrophysics Data System (ADS)

    Qian, Wei; Yu, Zhengyue; Wang, Xiaole; Lai, Yun; Yellen, Benjamin B.

    2016-02-01

    We demonstrate a dynamically tunable elastic metamaterial, which employs remote magnetic force to adjust its vibration absorption properties. The 1D metamaterial is constructed from a flat aluminum beam milled with a linear array of cylindrical holes. The beam is backed by a thin elastic membrane, on which thin disk-shaped permanent magnets are mounted. When excited by a shaker, the beam motion is tracked by a Laser Doppler Vibrometer, which conducts point by point scanning of the vibrating element. Elastic waves are unable to propagate through the beam when the driving frequency excites the first elastic bending mode in the unit cell. At these frequencies, the effective mass density of the unit cell becomes negative, which induces an exponentially decaying evanescent wave. Due to the non-linear elastic properties of the membrane, the effective stiffness of the unit cell can be tuned with an external magnetic force from nearby solenoids. Measurements of the linear and cubic static stiffness terms of the membrane are in excellent agreement with experimental measurements of the bandgap shift as a function of the applied force. In this implementation, bandgap shifts by as much as 40% can be achieved with ˜30 mN of applied magnetic force. This structure has potential for extension in 2D and 3D, providing a general approach for building dynamically tunable elastic metamaterials for applications in lensing and guiding elastic waves.

  10. STIFF: Converting Scientific FITS Images to TIFF

    NASA Astrophysics Data System (ADS)

    Bertin, Emmanuel

    2011-10-01

    STIFF is a program that converts scientific FITS1 images to the more popular TIFF2 format for illustration purposes. Most FITS readers and converters do not do a proper job at converting FITS image data to 8 bits. 8-bit images stored in JPEG, PNG or TIFF files have the intensities implicitely stored in a non-linear way. Most current FITS image viewers and converters provide the user an incorrect translation of the FITS image content by simply rescaling linearly input pixel values. A first consequence is that the people working on astronomical images usually have to apply narrow intensity cuts or square-root or logarithmic intensity transformations to actually see something on their deep-sky images. A less obvious consequence is that colors obtained by combining images processed this way are not consistent across such a large range of surface brightnesses. Though with other software the user is generally afforded a choice of nonlinear transformations to apply in order to make the faint stuff stand out more clearly in the images, with the limited selection of choices provides, colors will not be accurately rendered, and some manual tweaking will be necessary. The purpose of STIFF is to produce beautiful pictures in an automatic and consistent way.

  11. Damage detection using experimentally measured mass and stiffness matrices

    NASA Technical Reports Server (NTRS)

    Peterson, L. D.; Alvin, K. F.; Doebling, S. W.; Park, K. C.

    1993-01-01

    A method is presented for locating physical damage or change in a structure using experimentally measured mass and stiffness matrices. The approach uses a recently developed algorithm for transforming a state-space realization into a second order structural model with physical displacements as the generalized coordinates. This is accomplished by first rotating a state-space model of the identified structural dynamics into modal coordinates and approximating the mass normalized modal vectors for the output measurement set. Next, the physical mass, damping and stiffness matrices are synthesized directly from the measured modal parameters. This yields experimental mass and stiffness matrices for the structure without the use of a finite element model or a numerical search. The computed mass and stiffness are asymptotically equivalent to a static condensation of the global physical coordinate model. Techniques for solving the inverse connectivity problem are then developed whereby it is possible to assess the stiffness in a region of the structure bounded by several sensors. Applications to both simulated data and experimental data are used to discuss the effectiveness of the approach.

  12. Damage detection using experimentally measured mass and stiffness matrices

    NASA Astrophysics Data System (ADS)

    Peterson, L. D.; Alvin, K. F.; Doebling, S. W.; Park, K. C.

    1993-04-01

    A method is presented for locating physical damage or change in a structure using experimentally measured mass and stiffness matrices. The approach uses a recently developed algorithm for transforming a state-space realization into a second order structural model with physical displacements as the generalized coordinates. This is accomplished by first rotating a state-space model of the identified structural dynamics into modal coordinates and approximating the mass normalized modal vectors for the output measurement set. Next, the physical mass, damping and stiffness matrices are synthesized directly from the measured modal parameters. This yields experimental mass and stiffness matrices for the structure without the use of a finite element model or a numerical search. The computed mass and stiffness are asymptotically equivalent to a static condensation of the global physical coordinate model. Techniques for solving the inverse connectivity problem are then developed whereby it is possible to assess the stiffness in a region of the structure bounded by several sensors. Applications to both simulated data and experimental data are used to discuss the effectiveness of the approach.

  13. Comparison Between Neck and Shoulder Stiffness Determined by Shear Wave Ultrasound Elastography and a Muscle Hardness Meter.

    PubMed

    Akagi, Ryota; Kusama, Saki

    2015-08-01

    The goals of this study were to compare neck and shoulder stiffness values determined by shear wave ultrasound elastography with those obtained with a muscle hardness meter and to verify the correspondence between objective and subjective stiffness in the neck and shoulder. Twenty-four young men and women participated in the study. Their neck and shoulder stiffness was determined at six sites. Before the start of the measurements, patients rated their present subjective symptoms of neck and shoulder stiffness on a 6-point verbal scale. At all measurement sites, the correlation coefficients between the values of muscle hardness indices determined by the muscle hardness meter and shear wave ultrasound elastography were not significant. Furthermore, individuals' subjective neck and shoulder stiffness did not correspond to their objective symptoms. These results suggest that the use of shear wave ultrasound elastography is essential to more precisely assess neck and shoulder stiffness.

  14. Estimation of Quasi-Stiffness of the Human Knee in the Stance Phase of Walking

    PubMed Central

    Shamaei, Kamran; Sawicki, Gregory S.; Dollar, Aaron M.

    2013-01-01

    Biomechanical data characterizing the quasi-stiffness of lower-limb joints during human locomotion is limited. Understanding joint stiffness is critical for evaluating gait function and designing devices such as prostheses and orthoses intended to emulate biological properties of human legs. The knee joint moment-angle relationship is approximately linear in the flexion and extension stages of stance, exhibiting nearly constant stiffnesses, known as the quasi-stiffnesses of each stage. Using a generalized inverse dynamics analysis approach, we identify the key independent variables needed to predict knee quasi-stiffness during walking, including gait speed, knee excursion, and subject height and weight. Then, based on the identified key variables, we used experimental walking data for 136 conditions (speeds of 0.75–2.63 m/s) across 14 subjects to obtain best fit linear regressions for a set of general models, which were further simplified for the optimal gait speed. We found R2 > 86% for the most general models of knee quasi-stiffnesses for the flexion and extension stages of stance. With only subject height and weight, we could predict knee quasi-stiffness for preferred walking speed with average error of 9% with only one outlier. These results provide a useful framework and foundation for selecting subject-specific stiffness for prosthetic and exoskeletal devices designed to emulate biological knee function during walking. PMID:23533662

  15. Mechanism of leg stiffness adjustment for hopping on surfaces of different stiffnesses.

    PubMed

    Farley, C T; Houdijk, H H; Van Strien, C; Louie, M

    1998-09-01

    When humans hop in place or run forward, leg stiffness is increased to offset reductions in surface stiffness, allowing the global kinematics and mechanics to remain the same on all surfaces. The purpose of the present study was to determine the mechanism for adjusting leg stiffness. Seven subjects hopped in place on surfaces of different stiffnesses (23-35,000 kN/m) while force platform, kinematic, and electromyographic data were collected. Leg stiffness approximately doubled between the most stiff surface and the least stiff surface. Over the same range of surfaces, ankle torsional stiffness increased 1.75-fold, and the knee became more extended at the time of touchdown (2.81 vs. 2.65 rad). We used a computer simulation to examine the sensitivity of leg stiffness to the observed changes in ankle stiffness and touchdown knee angle. Our model consisted of four segments (foot, shank, thigh, head-arms-trunk) interconnected by three torsional springs (ankle, knee, hip). In the model, an increase in ankle stiffness 1.75-fold caused leg stiffness to increase 1.7-fold. A change in touchdown knee angle as observed in the subjects caused leg stiffness to increase 1.3-fold. Thus both joint stiffness and limb geometry adjustments are important in adjusting leg stiffness to allow similar hopping on different surfaces.

  16. 3D FEA simulation of segmented reinforcement variable stiffness composites

    NASA Astrophysics Data System (ADS)

    Henry, C. P.; McKnight, G. P.; Enke, A.; Bortolin, R.; Joshi, S.

    2008-03-01

    Reconfigurable and morphing structures may provide significant improvement in overall platform performance through optimization over broad operating conditions. The realization of this concept requires structures, which can accommodate the large deformations necessary with modest weight and strength penalties. Other studies suggest morphing structures need new materials to realize the benefits that morphing may provide. To help meet this need, we have developed novel composite materials based on specially designed segmented reinforcement and shape memory polymer matrices that provide unique combinations of deformation and stiffness properties. To tailor and optimize the design and fabrication of these materials for particular structural applications, one must understand the envelope of morphing material properties as a function of microstructural architecture and constituent properties. Here we extend our previous simulations of these materials by using 3D models to predict stiffness and deformation properties in variable stiffness segmented composite materials. To understand the effect of various geometry tradeoffs and constituent properties on the elastic stiffness in both the high and low stiffness states, we have performed a trade study using a commercial FEA analysis package. The modulus tensor is constructed and deformation properties are computed from representative volume elements (RVE) in which all (6) basic loading conditions are applied. Our test matrix consisted of four composite RVE geometries modeled using combinations of 5 SMP and 3 reinforcement elastic moduli. Effective composite stiffness and deformation results confirm earlier evidence of the essential performance tradeoffs of reduced stiffness for increasing reversible strain accommodation with especially heavy dependencies on matrix modulus and microstructural architecture. Furthermore, our results show these laminar materials are generally orthotropic and indicate that previous calculations of

  17. The relationship between trunk muscle activation and trunk stiffness: examining a non-constant stiffness gain.

    PubMed

    Brown, Stephen H M; McGill, Stuart M

    2010-12-01

    The relationship between muscle activation, force and stiffness needs to be known to interpret the stability state of the spine. To test the relationship between these variables, a quick release approach was used to match quantified torso stiffness with an EMG activation-based estimate of individual muscle stiffnesses. The relationship between activation, force and stiffness was modelled as k = q x F/l, where k, F and l are muscle stiffness, force and length, respectively, and q is the dimensionless stiffness gain relating these variables. Under the tested experimental scenario, the 'stiffness gain', q, which linked activation with stiffness, demonstrated a decreasing trend with increasing levels of torso muscle activation. This highlights the likelihood that the choice of a single q value may be over simplistic to relate force to stiffness in muscles that control the spine. This has implications for understanding the potential for spine instability in situations requiring high muscular demand.

  18. Simulation methods with extended stability for stiff biochemical Kinetics

    PubMed Central

    2010-01-01

    Background With increasing computer power, simulating the dynamics of complex systems in chemistry and biology is becoming increasingly routine. The modelling of individual reactions in (bio)chemical systems involves a large number of random events that can be simulated by the stochastic simulation algorithm (SSA). The key quantity is the step size, or waiting time, τ, whose value inversely depends on the size of the propensities of the different channel reactions and which needs to be re-evaluated after every firing event. Such a discrete event simulation may be extremely expensive, in particular for stiff systems where τ can be very short due to the fast kinetics of some of the channel reactions. Several alternative methods have been put forward to increase the integration step size. The so-called τ-leap approach takes a larger step size by allowing all the reactions to fire, from a Poisson or Binomial distribution, within that step. Although the expected value for the different species in the reactive system is maintained with respect to more precise methods, the variance at steady state can suffer from large errors as τ grows. Results In this paper we extend Poisson τ-leap methods to a general class of Runge-Kutta (RK) τ-leap methods. We show that with the proper selection of the coefficients, the variance of the extended τ-leap can be well-behaved, leading to significantly larger step sizes. Conclusions The benefit of adapting the extended method to the use of RK frameworks is clear in terms of speed of calculation, as the number of evaluations of the Poisson distribution is still one set per time step, as in the original τ-leap method. The approach paves the way to explore new multiscale methods to simulate (bio)chemical systems. PMID:20701766

  19. Dynamic phototuning of 3D hydrogel stiffness

    PubMed Central

    Stowers, Ryan S.; Allen, Shane C.; Suggs, Laura J.

    2015-01-01

    Hydrogels are widely used as in vitro culture models to mimic 3D cellular microenvironments. The stiffness of the extracellular matrix is known to influence cell phenotype, inspiring work toward unraveling the role of stiffness on cell behavior using hydrogels. However, in many biological processes such as embryonic development, wound healing, and tumorigenesis, the microenvironment is highly dynamic, leading to changes in matrix stiffness over a broad range of timescales. To recapitulate dynamic microenvironments, a hydrogel with temporally tunable stiffness is needed. Here, we present a system in which alginate gel stiffness can be temporally modulated by light-triggered release of calcium or a chelator from liposomes. Others have shown softening via photodegradation or stiffening via secondary cross-linking; however, our system is capable of both dynamic stiffening and softening. Dynamic modulation of stiffness can be induced at least 14 d after gelation and can be spatially controlled to produce gradients and patterns. We use this system to investigate the regulation of fibroblast morphology by stiffness in both nondegradable gels and gels with degradable elements. Interestingly, stiffening inhibits fibroblast spreading through either mesenchymal or amoeboid migration modes. We demonstrate this technology can be translated in vivo by using deeply penetrating near-infrared light for transdermal stiffness modulation, enabling external control of gel stiffness. Temporal modulation of hydrogel stiffness is a powerful tool that will enable investigation of the role that dynamic microenvironments play in biological processes both in vitro and in well-controlled in vivo experiments. PMID:25646417

  20. Difference methods for stiff delay differential equations. [DDESUB, in FORTRAN

    SciTech Connect

    Roth, Mitchell G.

    1980-12-01

    Delay differential equations of the form y'(t) = f(y(t), z(t)), where z(t) = (y/sub 1/(..cap alpha../sub 1/(y(t))),..., y/sub n/(..cap alpha../sub n/(y(t))))/sup T/ and ..cap alpha../sub i/(y(t)) less than or equal to t, arise in many scientific and engineering fields when transport lags and propagation times are physically significant in a dynamic process. Difference methods for approximating the solution of stiff delay systems require special stability properties that are generalizations of those employed for stiff ordinary differential equations. By use of the model equation y'(t) = py(t) + qy(t-1), with complex p and q, the definitions of A-stability, A( )-stability, and stiff stability have been generalize to delay equations. For linear multistep difference formulas, these properties extend directly from ordinary to delay equations. This straight forward extension is not true for implicit Runge-Kutta methods, as illustrated by the midpoint formula, which is A-stable for ordinary equations, but not for delay equations. A computer code for stiff delay equations was developed using the BDF. 24 figures, 5 tables.

  1. Modifiable Risk Factors for Increased Arterial Stiffness in Outpatient Nephrology

    PubMed Central

    Elewa, Usama; Fernandez-Fernandez, Beatriz; Alegre, Raquel; Sanchez-Niño, Maria D.; Mahillo-Fernández, Ignacio; Perez-Gomez, Maria Vanessa; El-Fishawy, Hussein; Belal, Dawlat; Ortiz, Alberto

    2015-01-01

    Arterial stiffness, as measured by pulse wave velocity (PWV), is an independent predictor of cardiovascular events and mortality. Arterial stiffness increases with age. However, modifiable risk factors such as smoking, BP and salt intake also impact on PWV. The finding of modifiable risk factors may lead to the identification of treatable factors, and, thus, is of interest to practicing nephrologist. We have now studied the prevalence and correlates of arterial stiffness, assessed by PWV, in 191 patients from nephrology outpatient clinics in order to identify modifiable risk factors for arterial stiffness that may in the future guide therapeutic decision-making. PWV was above normal levels for age in 85/191 (44.5%) patients. Multivariate analysis showed that advanced age, systolic BP, diabetes mellitus, serum uric acid and calcium polystyrene sulfonate therapy or calcium-containing medication were independent predictors of PWV. A new parameter, Delta above upper limit of normal PWV (Delta PWV) was defined to decrease the weight of age on PWV values. Delta PWV was calculated as (measured PWV) - (upper limit of the age-adjusted PWV values for the general population). Mean±SD Delta PWV was 0.76±1.60 m/sec. In multivariate analysis, systolic blood pressure, active smoking and calcium polystyrene sulfonate therapy remained independent predictors of higher delta PWV, while age, urinary potassium and beta blocker therapy were independent predictors of lower delta PWV. In conclusion, arterial stiffness was frequent in nephrology outpatients. Systolic blood pressure, smoking, serum uric acid, calcium-containing medications, potassium metabolism and non-use of beta blockers are modifiable factors associated with increased arterial stiffness in Nephrology outpatients. PMID:25880081

  2. Analysis and Design of Variable Stiffness Composite Cylinders

    NASA Technical Reports Server (NTRS)

    Tatting, Brian F.; Guerdal, Zafer

    1998-01-01

    An investigation of the possible performance improvements of thin circular cylindrical shells through the use of the variable stiffness concept is presented. The variable stiffness concept implies that the stiffness parameters change spatially throughout the structure. This situation is achieved mainly through the use of curvilinear fibers within a fiber-reinforced composite laminate, though the possibility of thickness variations and discrete stiffening elements is also allowed. These three mechanisms are incorporated into the constitutive laws for thin shells through the use of Classical Lamination Theory. The existence of stiffness variation within the structure warrants a formulation of the static equilibrium equations from the most basic principles. The governing equations include sufficient detail to correctly model several types of nonlinearity, including the formation of a nonlinear shell boundary layer as well as the Brazier effect due to nonlinear bending of long cylinders. Stress analysis and initial buckling estimates are formulated for a general variable stiffness cylinder. Results and comparisons for several simplifications of these highly complex governing equations are presented so that the ensuing numerical solutions are considered reliable and efficient enough for in-depth optimization studies. Four distinct cases of loading and stiffness variation are chosen to investigate possible areas of improvement that the variable stiffness concept may offer over traditional constant stiffness and/or stiffened structures. The initial investigation deals with the simplest solution for cylindrical shells in which all quantities are constant around the circumference of the cylinder. This axisymmetric case includes a stiffness variation exclusively in the axial direction, and the only pertinent loading scenarios include constant loads of axial compression, pressure, and torsion. The results for these cases indicate that little improvement over traditional

  3. Validity and reliability of clinical tests for assessing hip passive stiffness.

    PubMed

    Carvalhais, Viviane Otoni do Carmo; de Araújo, Vanessa Lara; Souza, Thales Rezende; Gonçalves, Gabriela Gomes Pavan; Ocarino, Juliana de Melo; Fonseca, Sérgio Teixeira

    2011-06-01

    Inadequate levels of hip passive joint stiffness have been associated with the occurrence of movement dysfunction, development of pathologies and reduction in performance. Clinical tests, designed to evaluate hip joint stiffness, may allow the identification of improper stiffness levels. The purpose of this study was to determine the concurrent validity as well as the intra- and inter-examiners reliabilities of clinical measures used to assess hip passive stiffness during internal rotation. Fifteen healthy participants were subjected to test-retest evaluations by two examiners. Two clinical measures were performed: 'position of first detectable resistance' and 'change in passive resistance torque'. The results of these tests were compared to the passive stiffness measured with an isokinetic dynamometer (gold standard measure). A significant correlation was found between the stiffness measured with the isokinetic dynamometer and the clinical measures of 'position of first detectable resistance' (r=-0.85 to -0.86, p<0.001) and 'change in passive resistance torque' (r=0.78 to 0.84, p≤0.001). The Intraclass Correlation Coefficients for intra- and inter-examiners reliabilities varied from 0.95 to 0.99. Thus, the results demonstrated that the clinical measures have adequate validity and reliability for obtaining information on hip passive stiffness during internal rotation. PMID:21212014

  4. Rolling bearing stiffness in arbitrary direction

    NASA Astrophysics Data System (ADS)

    Luo, Zhusan; Sun, Xinde; Wu, Linfeng

    1992-06-01

    This paper presents a new concept of rolling bearing stiffness in arbitrary direction, which is necessary to the investigation of rotor-bearing dynamics. It includes the axial stiffness and the arbitrary radial stiffness of the rolling bearing. Based on elasticity theory and the geometrical parameters of the bearing, the approximate formulas of the axial stiffness, the arbitrary radial stiffness, and the inner ring displacements are derived. Furthermore, the paper also discusses the effects of the loads, the radial clearance, and the load distribution parameters on the rolling bearing stiffness. In order to verify the model and the computer program, an example of a ball bearing is analyzed in detail. It shows that the model and the program are reliable and the results are consistent with the data supplied by the U.S. Air Force Aeropropulsion Laboratory.

  5. Leg stiffness measures depend on computational method.

    PubMed

    Hébert-Losier, Kim; Eriksson, Anders

    2014-01-01

    Leg stiffness is often computed from ground reaction force (GRF) registrations of vertical hops to estimate the force-resisting capacity of the lower-extremity during ground contact, with leg stiffness values incorporated in a spring-mass model to describe human motion. Individual biomechanical characteristics, including leg stiffness, were investigated in 40 healthy males. Our aim is to report and discuss the use of 13 different computational methods for evaluating leg stiffness from a double-legged repetitive hopping task, using only GRF registrations. Four approximations for the velocity integration constant were combined with three mathematical expressions, giving 12 methods for computing stiffness using double integrations. One frequency-based method that considered ground contact times was also trialled. The 13 methods thus defined were used to compute stiffness in four extreme cases, which were the stiffest, and most compliant, consistent and variable subjects. All methods provided different stiffness measures for a given individual, but the between-method variations in stiffness were consistent across the four atypical subjects. The frequency-based method apparently overestimated the actual stiffness values, whereas double integrations' measures were more consistent. In double integrations, the choice of the integration constant and mathematical expression considerably affected stiffness values, as variations during hopping were more or less emphasized. Stating a zero centre of mass position at take-off gave more consistent results, and taking a weighted-average of the force or displacement curve was more forgiving to variations in performance. In any case, stiffness values should always be accompanied by a detailed description of their evaluation methods, as our results demonstrated that computational methods affect calculated stiffness. PMID:24188972

  6. Arterial stiffness: pathophysiology and clinical impact.

    PubMed

    London, Gérard M; Marchais, Sylvain J; Guerin, Alain P; Pannier, Bruno

    2004-01-01

    The ill effects of hypertension are usually attributed to a reduction in the caliber or the number of arterioles, resulting in an increase in total peripheral resistance (TPR). This definition does not take into account the fact that BP is a cyclic phenomenon with systolic and diastolic BP being the limits of these oscillations. The appropriate term to define the arterial factor(s) opposing LV ejection is aortic input impedance which depends on TPR, arterial distensibility (D), and wave reflections (WR). D defines the capacitive properties of arterial stiffness, whose role is to dampen pressure and flow oscillations and to transform pulsatile flow and pressure in arteries into a steady flow and pressure in peripheral tissues. Stiffness is the reciprocal value of D. These parameters are BP dependent, and arteries become stiffer at high pressure. In to D which provides information about the of artery as a hollow structure, the elastic incremental modulus (Einc) characterizes the properties of the arterial wall biomaterials, independently of vessel geometry. As an alternative, arterial D can be evaluated by measuring the pulse wave velocity (PWV) which increases with the stiffening of arteries. Arterial stiffening increases left ventricular (LV) afterload and alters the coronary perfusion. With increased PWV, the WR impacts on the aorta during systole, increasing systolic pressures and myocardial oxygen consumption, and decreasing diastolic BP and coronary flow. The arterial stiffness is altered primarily in association with increased collagen content and alterations of extracellular matrix (arteriosclerosis) as classically observed during aging or in arterial hypertension. The arterial stiffening estimated by changes in aortic PWV and intensity of WR are independent predictors of survival in end stage renal disease (ESRD) and general population. Improvement of arterial stiffening could be obtained by antihypertensive treatmen as observed with the calcium

  7. On the correspondence between a large class of dynamical systems and stochastic processes described by the generalized Fokker-Planck equation with state-dependent diffusion and drift coefficients

    NASA Astrophysics Data System (ADS)

    Bianucci, Marco

    2015-05-01

    In this paper using a projection approach and defining the adjoint-Lie time evolution of differential operators, that generalizes the ordinary time evolution of functions, we obtain a Fokker-Planck equation for the distribution function of a part of interest of a large class of dynamical systems. The main assumptions are the weak interaction between the part of interest and the rest of the system (typically non linear) and the average linear response to external perturbations of the irrelevant part. We do not use ad hoc statistical assumptions to introduce as given a priori phenomenological equilibrium or transport coefficients. The drift terms induced by the interaction with the irrelevant part is obtained with a procedure that is reminiscent of that developed some years ago by Bianucci and Grigolini (see for example (Bianucci et al 1995 Phys. Rev. E 51 3002)) to derive in a ‘genuine’ way thermodynamics and statistical mechanics of macroscopic variables of interest starting from microscopic dynamics. However here we stay in a more broad and formal context where the system of interest could be dissipative and the interaction between the two systems could be non Hamiltonian, thus the approach of the cited paper can not be used to obtain the diffusion part of the Fokker-Planck equation. To face the problem of dealing with the series of differential operators stemming from the projection approach applied to this general case, we introduce the formalism of the Lie derivative and the corresponding adjoint-Lie time evolution of differential operators. In this theoretical framework we are able to obtain well defined analytic functions both for the drift and the diffusion coefficients of the Fokker-Planck equation. We think that the basic elements of Lie algebra introduced in our projection approach can be useful to achieve even more general and more formally elegant results than those here presented. Thus we consider this paper as a first step of this formal path to

  8. Factor Scores, Structure Coefficients, and Communality Coefficients

    ERIC Educational Resources Information Center

    Goodwyn, Fara

    2012-01-01

    This paper presents heuristic explanations of factor scores, structure coefficients, and communality coefficients. Common misconceptions regarding these topics are clarified. In addition, (a) the regression (b) Bartlett, (c) Anderson-Rubin, and (d) Thompson methods for calculating factor scores are reviewed. Syntax necessary to execute all four…

  9. Development of Zero Coefficient of Thermal Expansion composite tubes for stable space structures

    NASA Astrophysics Data System (ADS)

    Strock, John D.

    1992-09-01

    Advanced composite materials are well suited for stable space structures due to their low Coefficient of Thermal Expansion (CTE), high stiffness and light weight. For a given design application, composite hardware can be tailored for strength, stiffness, CTE, and Coefficient of Moisture Expansion (CME). Computer modeling and laminate testing of high modulus graphite/epoxy tubes were evaluated for compressive strength, stiffness, CTE, CME and microcracking. Thermal cycling and microcracking effects on CTE were evaluated. Thin graphite/epoxy plies exhibited reduced microcracking. A zero CTE thin wall tube design resulted from the development program. Recent work on low moisture absorption resin systems is also discussed.

  10. Vibration transmission through rolling element bearings, part I: Bearing stiffness formulation

    NASA Astrophysics Data System (ADS)

    Lim, T. C.; Singh, R.

    1990-06-01

    Current bearing models, based on either ideal boundary condition or purely translational stiffness element description, cannot explain how the vibratory motion may be transmitted from the rotating shaft to the casing and other connecting structures in rotating mechanical equipment. For example, a vibration model of a rotating system based upon the existing bearing models can predict only the purely in-plane type motion on the flexible casing plate given only the bending motion on the shaft. However, experimental results have shown that the casing plate motion is primarily flexural or out-of-plane type. In this paper this issue is claridied quantitatively and qualitatively by developing a new mathematical model for the precision rolling element bearings from basic principles. A comprehensive bearing stiffness matrix [ K] bm of dimension six is proposed which clearly demonstrates a coupling between the shaft bending motion and the flexural motion on the casing plate. A numerical scheme which involves a solution of non-linear algebraic equations is proposed for the estimation of the stiffness coefficients given the mean bearing load vector. A second method which requires the direct evaluation of these stiffness coefficients given the mean bearing displacement vector is also discussed. Some of the translational stiffness coefficients of the proposed bearing matrix have been verified by using available analytical and experimental data. Further validation of [ K] bm is not possible as coupling coefficients are never measured. Also, parametric studies on the effect of unloaded contact angle, preload or bearing type are included. These results lead to a complete characterization of the bearing stiffness matrix. The theory is used to analyze vibration transmission properties in the companion paper, Part II.

  11. A novel assessment technique for measuring ankle orientation and stiffness.

    PubMed

    Zhang, Mingming; Davies, T Claire; Nandakumar, Anoop; Quan Xie, Sheng

    2015-09-18

    The measurement of ankle orientation and stiffness can provide insight into improvements and allows for effective monitoring during a rehabilitation program. Existing assessment techniques have a variety of limitations. Dynamometer based methods rely on manual manipulation. The use of torque meter is usually for single degree-of-freedom (DOF) devices. This study proposes a novel ankle assessment technique that can be used for multiple DOFs devices working in both manual and automatic modes using the position sensor and the multi-axis load cell. As a preliminary evaluation, an assessment device for ankle dorsiflexion and plantarflexion was constructed. Nine subjects participated to evaluate the effectiveness of the assessment device in determining ankle orientation and stiffness. The measured ankle orientation was consistent with that from the NDI Polaris optical tracking system. The measured ankle torque and stiffness compared well with published data. The test-retest reliability was high with intraclass correlation coefficient (ICC2, 1) values greater than 0.846 and standard error of measurement (SEM) less than 1.38. PMID:26159061

  12. The posttraumatic stiff elbow: an update.

    PubMed

    Mellema, Jos J; Lindenhovius, Anneluuk L C; Jupiter, Jesse B

    2016-06-01

    Posttraumatic elbow stiffness is a disabling condition that remains challenging to treat despite improvement of our understanding of the pathogenesis of posttraumatic contractures and new treatment regimens. This review provides an update and overview of the etiology of posttraumatic elbow stiffness, its classification, evaluation, nonoperative and operative treatment, and postoperative management.

  13. Nonparticipatory Stiffness in the Male Perioral Complex

    ERIC Educational Resources Information Center

    Chu, Shin-Ying; Barlow, Steven M.; Lee, Jaehoon

    2009-01-01

    Purpose: The objective of this study was to extend previous published findings in the authors' laboratory using a new automated technology to quantitatively characterize nonparticipatory perioral stiffness in healthy male adults. Method: Quantitative measures of perioral stiffness were sampled during a nonparticipatory task using a…

  14. Concept for design of variable stiffness damper

    NASA Technical Reports Server (NTRS)

    Lohr, J. J.

    1967-01-01

    Damping mechanism, containing polymeric-like materials is applicable to a wide range of shock and vibration. The polymeric-like material changes from a relatively stiff material to a relatively soft, rubbery material in the region of their glass transition temperatures. The energy absorption characteristics and stiffness are controllable with temperature.

  15. Curvature dependent modulation of fish fin stiffness

    NASA Astrophysics Data System (ADS)

    Nguyen, Khoi; Yu, Ning; Bandi, Mahesh; Venkadesan, Madhusudhan; Mandre, Shreyas

    Propulsion and maneuvering ability of fishes depends on the stiffness of their fins. However, increasing stiffness by simply adding material to thicken the fin would incur a substantial energetic cost associated with flapping the fin. We propose that fishes increase stiffness of the fin not by building thicker fins, but by geometrically coupling out-of-plane bending of the fin's rays with in-plane stretching of a stiff membrane that connects the rays. We present a model of fin elasticity for ray-finned fish, where we decompose the fin into a series of elastic beams (rays) with springy interconnections (membrane). In one limit, where the membranes are infinitely extensible, the fin's stiffness is no more than the sum of the stiffness of individual rays. At the other limit of an inextensible membrane, fin stiffness reaches an asymptotic maximum. The asymptote value increases monotonically with curvature. We propose that musculature at the base of the fin controls fin curvature, and thereby modulates stiffness.

  16. Cervical Stiffness Evaluated In Vivo by Endoflip in Pregnant Women

    PubMed Central

    Hee, Lene; Liao, Donghua; Sandager, Puk; Gregersen, Hans; Uldbjerg, Niels

    2014-01-01

    Objective To determine the stiffness of the pregnant uterine cervix in vivo. Method Five women in early pregnancy and six women in late pregnancy were included. The EndoFlip is a 1-m-long probe with a 12-cm-long bag mounted on the tip. The tip of the probe was inserted into the cervical canal. Sensors spaced at 0.5-cm intervals along the probe were used to determine 16 serial cross-sectional areas of the bag. The diameter of the cervical canal could thereby be determined during inflation with up to 50 ml saline solution. Tissue stiffness was calculated from the geometric profiles and the pressure-strain elastic modulus (EP) at each sensor site. Three parts of the cervix were defined: the uterus-near part, the middle and the vaginal part. The EPmax was defined as the highest EP detected along the cervical canal. Results The EPmax was always found in the middle part of the cervix. The median EPmax was 243 kPa (IQR, 67–422 kPa) for the early pregnant women and 5 kPa (IQR, 4–15 kPa) for those at term. In the early pregnant women the stiffness differed along the cervical length (p<0.05) whereas difference along the cervix was not found for late pregnant women. A positive correlation coefficient (Spearman’s rho) was established between the EPs of the uterus-near and the middle part (0.84), between the vaginal and the middle part (0.81), and between the uterus-near and the vaginal part (0.85). Conclusion This new method can estimate the stiffness along the cervical canal in vivo. This method may be useful in the clinical examination of the biomechanical properties of the uterine cervix. PMID:24603859

  17. Estimating the Polyserial Correlation Coefficient.

    ERIC Educational Resources Information Center

    Bedrick, Edward J.; Breslin, Frederick C.

    1996-01-01

    Simple noniterative estimators of the polyserial correlation coefficient are developed by exploiting a general relationship between the polyserial correlation and the point polyserial correlation to give extensions of the biserial estimators of K. Pearson (1909), H. E. Brogden (1949), and F. M. Lord (1963) to the multicategory setting. (SLD)

  18. Rolling Element Bearing Stiffness Matrix Determination (Presentation)

    SciTech Connect

    Guo, Y.; Parker, R.

    2014-01-01

    Current theoretical bearing models differ in their stiffness estimates because of different model assumptions. In this study, a finite element/contact mechanics model is developed for rolling element bearings with the focus of obtaining accurate bearing stiffness for a wide range of bearing types and parameters. A combined surface integral and finite element method is used to solve for the contact mechanics between the rolling elements and races. This model captures the time-dependent characteristics of the bearing contact due to the orbital motion of the rolling elements. A numerical method is developed to determine the full bearing stiffness matrix corresponding to two radial, one axial, and two angular coordinates; the rotation about the shaft axis is free by design. This proposed stiffness determination method is validated against experiments in the literature and compared to existing analytical models and widely used advanced computational methods. The fully-populated stiffness matrix demonstrates the coupling between bearing radial, axial, and tilting bearing deflections.

  19. Arterial Stiffness in Nonhypertensive Type 2 Diabetes Patients in Ghana

    PubMed Central

    Antwi, Daniel A.; Gyan, Ben

    2016-01-01

    Background. Increased arterial stiffness is an independent cardiovascular risk factor in diabetes patients and general population. However, the contribution of diabetes to arterial stiffness is often masked by coexistent obesity and hypertension. In this study, we assessed arterial stiffness in nonhypertensive, nonobese type 2 diabetes (T2DM) patients in Ghana. Methods. In case-control design, 166 nonhypertensive, nonobese participants, comprising 96 T2DM patients and 70 nondiabetes controls, were recruited. Peripheral and central blood pressure (BP) indices were measured, and arterial stiffness was assessed as aortic pulse wave velocity (PWVao), augmentation index (AIx), cardioankle vascular index (CAVI), and heart-ankle pulse wave velocity (haPWV). Results. With similar peripheral and central BP indices, T2DM patients had higher PWVao (8.3 ± 1 versus 7.8 ± 1.3, p = 0.044) and CAVI (7.9 ± 1.2 versus 6.9 ± 0.7, p = 0.021) than nondiabetic control. AIx and haPWV were similar between T2DM and nondiabetic controls. Multiple regression models showed that, in the entire study participants, the major determinants of PWVao were diabetes status, age, gender, systolic BP, and previous smoking status (β = 0.22, 0.36, 0.48, 0.21, and 0.25, resp.; all p < 0.05); the determinants of CAVI were diabetes status, age, BMI, heart rate, HbA1c, total cholesterol, HDL cholesterol, and previous smoking status (β = 0.21, 0.38, 0.2, 0.18, 0.24. 0.2, −0.19, and 0.2, resp.; all p < 0.05). Conclusion. Our findings suggest that nonhypertensive, nonobese T2DM patients have increased arterial stiffness without appreciable increase in peripheral and central pressure indices. PMID:27774104

  20. The Difference between Stiffness and Quasi-stiffness in the Context of Biomechanical Modeling

    PubMed Central

    Rouse, Elliott J.; Gregg, Robert D.; Hargrove, Levi J.; Sensinger, Jonathon W.

    2014-01-01

    The ankle contributes the majority of mechanical power during walking and is a frequently studied joint in biomechanics. Specifically, researchers have extensively investigated the torque-angle relationship for the ankle during dynamic tasks, such as walking and running. The slope of this relationship has been termed the “quasi-stiffness.” However, over time, researchers have begun to interchange the concepts of quasi-stiffness and stiffness. This is an especially important distinction as researchers currently begin to investigate the appropriate control systems for recently developed powered prosthetic legs. The quasi-stiffness and stiffness are distinct concepts in the context of powered joints, and are equivalent in the context of passive joints. The purpose of this paper is to demonstrate the difference between the stiffness and quasi-stiffness using a simple impedance controlled inverted pendulum model and a more sophisticated biped walking model, each with the ability to modify the trajectory of an impedance controller’s equilibrium angle position. In both cases, stiffness values are specified by the controller and the quasi-stiffness are shown during a single step. Both models have widely varying quasi-stiffness but each have a single stiffness value. Therefore, from this simple modeling approach, the differences and similarities between these two concepts are elucidated. PMID:23212310

  1. Dynamic stiffness matrix development and free vibration analysis of a moving beam

    NASA Astrophysics Data System (ADS)

    Banerjee, J. R.; Gunawardana, W. D.

    2007-06-01

    The dynamic stiffness matrix of a moving Bernoulli-Euler beam is developed and used to investigate its free flexural vibration characteristics. In order to develop the dynamic stiffness matrix, it is necessary to derive and solve the governing differential equation of motion of the moving beam in closed analytical form. The solution is then used to obtain the general expressions for both responses and loads. Boundary conditions are applied to determine the constants in the general solution, leading to the formation of the frequency dependent dynamic stiffness matrix of the moving beam, relating the amplitudes of the harmonically varying loads to those of the corresponding responses. The application of the resulting dynamic stiffness matrix using the Wittrick-Williams algorithm is demonstrated by some illustrative examples. Numerical results for both simply supported and fixed-fixed end conditions of the beam are discussed, and wherever possible, some are compared with those available in the literature.

  2. "Contact" of nanoscale stiff films.

    PubMed

    Yang, Fut K; Zhang, Wei; Han, Yougun; Yoffe, Serge; Cho, Yungchi; Zhao, Boxin

    2012-06-26

    We investigated the contact behaviors of a nanoscopic stiff thin film bonded to a compliant substrate and derived an analytical solution for determining the elastic modulus of thin films. Microscopic contact deformations of the gold and polydopamine thin films (<200 nm) coated on polydimethylsiloxane elastomers were measured by indenting a soft tip and analyzed in the framework of the classical plate theory and Johnson-Kendall-Roberts (JKR) contact mechanics. The analysis of this thin film contact mechanics focused on the bending and stretching resistance of thin films and is fundamentally different from conventional indentation measurements where the focus is on the fracture and compression of the films. The analytical solution of the elastic modulus of nanoscopic thin films was validated experimentally using 50 and 100 nm gold thin films coated on polydimethylsiloxane elastomers. The technical application of this analysis was further demonstrated by measuring the elastic modulus of thin films of polydopamine, a recently discovered biomimetic universal coating material. Furthermore, the method presented here is able to quantify the contact behaviors of nanoscopic thin films, effectively providing fundamental design parameters, the elastic modulus, and the work of adhesion, crucial for transferring them effectively into practical applications. PMID:22616836

  3. Model-based estimation of knee stiffness.

    PubMed

    Pfeifer, Serge; Vallery, Heike; Hardegger, Michael; Riener, Robert; Perreault, Eric J

    2012-09-01

    During natural locomotion, the stiffness of the human knee is modulated continuously and subconsciously according to the demands of activity and terrain. Given modern actuator technology, powered transfemoral prostheses could theoretically provide a similar degree of sophistication and function. However, experimentally quantifying knee stiffness modulation during natural gait is challenging. Alternatively, joint stiffness could be estimated in a less disruptive manner using electromyography (EMG) combined with kinetic and kinematic measurements to estimate muscle force, together with models that relate muscle force to stiffness. Here we present the first step in that process, where we develop such an approach and evaluate it in isometric conditions, where experimental measurements are more feasible. Our EMG-guided modeling approach allows us to consider conditions with antagonistic muscle activation, a phenomenon commonly observed in physiological gait. Our validation shows that model-based estimates of knee joint stiffness coincide well with experimental data obtained using conventional perturbation techniques. We conclude that knee stiffness can be accurately estimated in isometric conditions without applying perturbations, which presents an important step toward our ultimate goal of quantifying knee stiffness during gait.

  4. Model-Based Estimation of Knee Stiffness

    PubMed Central

    Pfeifer, Serge; Vallery, Heike; Hardegger, Michael; Riener, Robert; Perreault, Eric J.

    2013-01-01

    During natural locomotion, the stiffness of the human knee is modulated continuously and subconsciously according to the demands of activity and terrain. Given modern actuator technology, powered transfemoral prostheses could theoretically provide a similar degree of sophistication and function. However, experimentally quantifying knee stiffness modulation during natural gait is challenging. Alternatively, joint stiffness could be estimated in a less disruptive manner using electromyography (EMG) combined with kinetic and kinematic measurements to estimate muscle force, together with models that relate muscle force to stiffness. Here we present the first step in that process, where we develop such an approach and evaluate it in isometric conditions, where experimental measurements are more feasible. Our EMG-guided modeling approach allows us to consider conditions with antagonistic muscle activation, a phenomenon commonly observed in physiological gait. Our validation shows that model-based estimates of knee joint stiffness coincide well with experimental data obtained using conventional perturbation techniques. We conclude that knee stiffness can be accurately estimated in isometric conditions without applying perturbations, which presents an important step towards our ultimate goal of quantifying knee stiffness during gait. PMID:22801482

  5. Stiff substrates enhance cultured neuronal network activity

    PubMed Central

    Zhang, Quan-You; Zhang, Yan-Yan; Xie, Jing; Li, Chen-Xu; Chen, Wei-Yi; Liu, Bai-Lin; Wu, Xiao-an; Li, Shu-Na; Huo, Bo; Jiang, Lin-Hua; Zhao, Hu-Cheng

    2014-01-01

    The mechanical property of extracellular matrix and cell-supporting substrates is known to modulate neuronal growth, differentiation, extension and branching. Here we show that substrate stiffness is an important microenvironmental cue, to which mouse hippocampal neurons respond and integrate into synapse formation and transmission in cultured neuronal network. Hippocampal neurons were cultured on polydimethylsiloxane substrates fabricated to have similar surface properties but a 10-fold difference in Young's modulus. Voltage-gated Ca2+ channel currents determined by patch-clamp recording were greater in neurons on stiff substrates than on soft substrates. Ca2+ oscillations in cultured neuronal network monitored using time-lapse single cell imaging increased in both amplitude and frequency among neurons on stiff substrates. Consistently, synaptic connectivity recorded by paired recording was enhanced between neurons on stiff substrates. Furthermore, spontaneous excitatory postsynaptic activity became greater and more frequent in neurons on stiff substrates. Evoked excitatory transmitter release and excitatory postsynaptic currents also were heightened at synapses between neurons on stiff substrates. Taken together, our results provide compelling evidence to show that substrate stiffness is an important biophysical factor modulating synapse connectivity and transmission in cultured hippocampal neuronal network. Such information is useful in designing instructive scaffolds or supporting substrates for neural tissue engineering. PMID:25163607

  6. High performance composites with active stiffness control.

    PubMed

    Tridech, Charnwit; Maples, Henry A; Robinson, Paul; Bismarck, Alexander

    2013-09-25

    High performance carbon fiber reinforced composites with controllable stiffness could revolutionize the use of composite materials in structural applications. Here we describe a structural material, which has a stiffness that can be actively controlled on demand. Such a material could have applications in morphing wings or deployable structures. A carbon fiber reinforced-epoxy composite is described that can undergo an 88% reduction in flexural stiffness at elevated temperatures and fully recover when cooled, with no discernible damage or loss in properties. Once the stiffness has been reduced, the required deformations can be achieved at much lower actuation forces. For this proof-of-concept study a thin polyacrylamide (PAAm) layer was electrocoated onto carbon fibers that were then embedded into an epoxy matrix via resin infusion. Heating the PAAm coating above its glass transition temperature caused it to soften and allowed the fibers to slide within the matrix. To produce the stiffness change the carbon fibers were used as resistance heating elements by passing a current through them. When the PAAm coating had softened, the ability of the interphase to transfer load to the fibers was significantly reduced, greatly lowering the flexural stiffness of the composite. By changing the moisture content in PAAm fiber coating, the temperature at which the PAAm softens and the composites undergo a reduction in stiffness can be tuned. PMID:23978266

  7. Physiotherapy assessment of shoulder stiffness and how it influences management

    PubMed Central

    Russell, Sarah

    2015-01-01

    Common causes of shoulder stiffness include osteoarthritis, trauma, rheumatological conditions and stiffness secondary to soft tissue adaptation. Physiotherapy assessment of the stiff shoulder aims to ascertain the key causative factors of stiffness to inform effective management planning. Identification of whether a patient presents with pain or stiffness as their predominant symptom further guides treatment selection. The current evidence base underpins a management algorithm which has been developed to guide the assessment and management of patients presenting with shoulder stiffness. PMID:27582980

  8. Aortic Stiffness, Cerebrovascular Dysfunction, and Memory

    PubMed Central

    Cooper, Leroy L.; Mitchell, Gary F.

    2016-01-01

    Background Aortic stiffness is associated with cardiovascular and cerebrovascular events and cognitive decline. This mini-review focuses on relations of aortic stiffness with microvascular dysfunction and discusses the contribution of abnormal pulsatile hemodynamics to cerebrovascular damage and cognitive decline. We also provide a rationale for considering aortic stiffness as a putative and important contributor to memory impairment in older individuals. Summary Aging is associated with stiffening of the aorta but not the muscular arteries, which reduces wave reflection and increases the transmission of pulsatility into the periphery. Aortic stiffening thereby impairs a protective mechanism that shields the peripheral microcirculation from excessive pulsatility within downstream target organs. Beyond midlife, aortic stiffness increases rapidly and exposes the cerebral microcirculation to abnormal pulsatile mechanical forces that are associated with microvascular damage and remodeling in the brain. Aortic stiffening and high-flow pulsatility are associated with alterations in the microvasculature of the brain; however, a mechanistic link between aortic stiffness and memory has not been established. We showed that in a community-based sample of older individuals, cerebrovascular resistance and white matter hyperintensities - markers of cerebrovascular remodeling and damage - mediated the relation between higher aortic stiffness and lower performance on memory function tests. These data suggest that microvascular and white matter damage associated with excessive aortic stiffness contribute to impaired memory function with advancing age. Key Messages Increasing evidence suggests that vascular etiologies - including aortic stiffness and microvascular damage - contribute to memory impairment and the pathogenesis of dementia, including Alzheimer's disease. Interventions that reduce aortic stiffness may delay memory decline among older individuals. PMID:27752478

  9. Materials analogue of zero-stiffness structures

    NASA Astrophysics Data System (ADS)

    Kumar, Arun; Subramaniam, Anandh

    2011-04-01

    Anglepoise lamps and certain tensegrities are examples of zero-stiffness structures. These structures are in a state of neutral equilibrium with respect to changes in configuration of the system. Using Eshelby's example of an edge dislocation in a thin plate that can bend, we report the discovery of a non-trivial new class of material structures as an analogue to zero-stiffness structures. For extended positions of the edge dislocation in these structures, the dislocation experiences a zero image force. Salient features of these material structures along with the key differences from conventional zero-stiffness structures are pointed out.

  10. Pseudo analytical solution to time periodic stiffness systems

    NASA Astrophysics Data System (ADS)

    Wang, Yan-Zhong; Zhou, Yuan-Zi

    2011-04-01

    An analytical form of state transition matrix for a system of equations with time periodic stiffness is derived in order to solve the free response and also allow for the determination of system stability and bifurcation. A pseudo-closed form complete solution for parametrically excited systems subjected to inhomogeneous generalized forcing is developed, based on the Fourier expansion of periodic matrices and the substitution of matrix exponential terms via Lagrange—Sylvester theorem. A Mathieu type of equation with large amplitude is presented to demonstrate the method of formulating state transition matrix and Floquet multipliers. A two-degree-of-freedom system with irregular time periodic stiffness characterized by spiral bevel gear mesh vibration is presented to find forced response in stability and instability. The obtained results are presented and discussed.

  11. “Smooth Muscle Cell Stiffness Syndrome”—Revisiting the Structural Basis of Arterial Stiffness

    PubMed Central

    Sehgel, Nancy L.; Vatner, Stephen F.; Meininger, Gerald A.

    2015-01-01

    In recent decades, the pervasiveness of increased arterial stiffness in patients with cardiovascular disease has become increasingly apparent. Though, this phenomenon has been well documented in humans and animal models of disease for well over a century, there has been surprisingly limited development in a deeper mechanistic understanding of arterial stiffness. Much of the historical literature has focused on changes in extracellular matrix proteins—collagen and elastin. However, extracellular matrix changes alone appear insufficient to consistently account for observed changes in vascular stiffness, which we observed in our studies of aortic stiffness in aging monkeys. This led us to examine novel mechanisms operating at the level of the vascular smooth muscle cell (VSMC)—that include increased cell stiffness and adhesion to extracellular matrix—which that may be interrelated with other mechanisms contributing to arterial stiffness. We introduce these observations as a new concept—the Smooth Muscle Cell Stiffness Syndrome (SMCSS)—within the field of arterial stiffness and posit that stiffening of vascular cells impairs vascular function and may contribute stiffening to the vasculature with aging and cardiovascular disease. Importantly, this review article revisits the structural basis of arterial stiffness in light of these novel findings. Such classification of SMCSS and its contextualization into our current understanding of vascular mechanics may be useful in the development of strategic therapeutics to directly target arterial stiffness. PMID:26635621

  12. Is passive metatarsophalangeal joint stiffness related to leg stiffness, vertical stiffness and running economy during sub-maximal running?

    PubMed

    Man, Hok Sum; Lam, Wing Kai; Lee, Justin; Capio, Catherine M; Leung, Aaron Kam Lun

    2016-09-01

    This study examined whether passive metatarsophalangeal joints (MPJ) stiffness was associated with leg stiffness (Kleg) vertical stiffness (Kvert) and running economy (RE) during sub-maximal running. Nine male experienced runners underwent passive MPJ stiffness measurements in standing and sitting positions followed by sub-maximal running on an instrumented treadmill. With the individual foot position properly aligned, the MPJ passive stiffness in both sitting (MPJsit) and standing positions (MPJstand) were measured with a computerized dynamometer. Data were collected at a running speed of 2.78m/s, representing a stabilized level of energy expenditure. Pedar pressure insole was used to determine the contact time (tc) and peak reaction force for the calculation of Kleg and Kvert. A respiratory gas analysis system was used to estimate the RE. Bivariate correlation test was performed to examine the correlation among MPJ stiffness, contact time, Kleg, Kvert, and RE. The results showed that MPJsit and MPJstand were inversely correlated with RE (p=0.04, r=-0.68 to -0.69), suggesting that stiffer MPJ improves RE. In addition, MPJsit was correlated positively with Kleg (p<0.01, r=0.87),Kvert (p=0.03, r=0.70) but inversely with tc (p=0.02, r=-0.76), while MPJstand was correlated positively with the Kvert (p=0.02, r=0.77). These findings suggested that strength of toe plantar flexors provides stability and agility in the stance phase for more effective and faster forward movement.

  13. Determination of ball bearing dynamic stiffness

    NASA Technical Reports Server (NTRS)

    Beatty, R. F.; Rowan, B. F.

    1982-01-01

    The dynamic radial stiffness characteristics of rolling element bearings are currently determined by analytical methods that have not been experimentally verified. These bearing data are vital to rotating machinery design integrity because accurate critical speeds and rotor stability predictions are highly dependent on the bearing stiffness. A tester was designed capable of controlling the bearing axial preload, speed, and rotor unbalance. The rotor and support structures were constructed to permit critical speeds that are predominantly determined by a 57 mm test bearing. A curve of calculated critical speed versus stiffness was used to determine the actual bearing stiffness from the empirical data. The results of extensive testing are used to verify analytical predictions, increase confidence in existing bearing computer programs, and to serve as a data base for efforts to correct these programs.

  14. Exercise, Vascular Stiffness, and Tissue Transglutaminase

    PubMed Central

    Steppan, Jochen; Sikka, Gautam; Jandu, Simran; Barodka, Viachaslau; Halushka, Marc K.; Flavahan, Nicholas A.; Belkin, Alexey M.; Nyhan, Daniel; Butlin, Mark; Avolio, Alberto; Berkowitz, Dan E.; Santhanam, Lakshmi

    2014-01-01

    Background Vascular aging is closely associated with increased vascular stiffness. It has recently been demonstrated that decreased nitric oxide (NO)‐induced S‐nitrosylation of tissue transglutaminase (TG2) contributes to age‐related vascular stiffness. In the current study, we tested the hypothesis that exercise restores NO signaling and attenuates vascular stiffness by decreasing TG2 activity and cross‐linking in an aging rat model. Methods and Results Rats were subjected to 12 weeks of moderate aerobic exercise. Aging was associated with diminished phosphorylated endothelial nitric oxide synthase and phosphorylated vasodilator‐stimulated phosphoprotein abundance, suggesting reduced NO signaling. TG2 cross‐linking activity was significantly increased in old animals, whereas TG2 abundance remained unchanged. These alterations were attenuated in the exercise cohort. Simultaneous measurement of blood pressure and pulse wave velocity (PWV) demonstrated increased aortic stiffness in old rats, compared to young, at all values of mean arterial pressure (MAP). The PWV‐MAP correlation in the old sedentary and old exercise cohorts was similar. Tensile testing of the vessels showed increased stiffness of the aorta in the old phenotype with a modest restoration of mechanical properties toward the young phenotype with exercise. Conclusions Increased vascular stiffness during aging is associated with decreased TG2 S‐nitrosylation, increased TG2 cross‐linking activity, and increased vascular stiffness likely the result of decreased NO bioavailability. In this study, a brief period of moderate aerobic exercise enhanced NO signaling, attenuated TG cross‐linking activity, and reduced ex vivo tensile properties, but failed to reverse functional vascular stiffness in vivo, as measured by PWV. PMID:24721796

  15. [A contribution to "stiff man" syndrome].

    PubMed

    Belian, T; Harms, L

    1990-05-01

    A patient with the clinical symptoms of the "Stiff-man"-syndrome, but an atypical course was introduced. Symptoms and course were compared with similar cases mentioned in literature. The "Stiff-man"-syndrome is probably a disease of central origin affecting the relationship between inhibitory and excitatory regulation of the muscle tonus, especially the exteroceptive reflex mechanisms. Several pathological processes of the CNS can be held responsible for the disturbance of the balance in this regulatory system. PMID:2167489

  16. OroSTIFF: Face-referenced measurement of perioral stiffness in health and disease.

    PubMed

    Chu, Shin-Ying; Barlow, Steven M; Kieweg, Douglas; Lee, Jaehoon

    2010-05-28

    A new device and automated measurement technology known as OroSTIFF is described to characterize non-participatory perioral stiffness in healthy adults for eventual application to patients with orofacial movement disorders associated with neuromotor disease, traumatic injury, or congenital clefts of the upper lip. Previous studies of perioral biomechanics required head stabilization for extended periods of time during measurement, which precluded sampling patients with involuntary body/head movements (dyskinesias), or pediatric subjects. The OroSTIFF device is face-referenced and avoids the complications associated with head-restraint. Supporting data of non-participatory perioral tissue stiffness using OroSTIFF are included from 10 male and 10 female healthy subjects. The OroSTIFF device incorporates a pneumatic glass air cylinder actuator instrumented for pressure, and an integrated subminiature displacement sensor to encode lip aperture. Perioral electromyograms were simultaneously sampled to confirm passive muscle state for the superior and inferior divisions of the orbicularis oris muscles. Perioral stiffness, derived as a quotient from resultant force (DeltaF) and interangle span (DeltaX), was modeled with multilevel regression techniques. Real-time calculation of the perioral stiffness function demonstrated a significant quadratic relation between imposed interangle stretch and resultant force. This stiffness growth function also differed significantly between males and females. This study demonstrates the OroSTIFF 'proof-of-concept' for cost-effective non-invasive stimulus generation and derivation of perioral stiffness in a group of healthy unrestrained adults, and a case study to illustrate the dose-dependent effects of Levodopa on perioral stiffness in an individual with advanced Parkinson's disease who exhibited marked dyskinesia and rigidity.

  17. Numerical assessment of the stiffness index.

    PubMed

    Epstein, Sally; Vergnaud, Anne-Claire; Elliott, Paul; Chowienczyk, Phil; Alastruey, Jordi

    2014-01-01

    Elevated systemic vascular stiffness is associated with increased risk of cardiovascular disease. It has been suggested that the time difference between the two characteristic peaks of the digital volume pulse (DVP) measured at the finger using photoplethysmography is related to the stiffness of the arterial tree, and inversely proportional to the stiffness index (SI). However, the precise physical meaning of the SI and its relation to aortic pulse wave velocity (aPWV) is yet to be ascertained. In this study we investigated numerically the effect of changes in arterial wall stiffness, peripheral resistances, peripheral compliances or peripheral wave reflections on the SI and aPWV. The SI was calculated from the digital area waveform simulated using a nonlinear one-dimensional model of pulse wave propagation in a 75-artery network, which includes the larger arteries of the hand. Our results show that aPWV is affected by changes in aortic stiffness, but the SI is primarily affected by changes in the stiffness of all conduit vessels. Thus, the SI is not a direct substitute for aPWV. Moreover, our results suggest that peripheral reflections in the upper body delay the time of arrival of the first peak in the DVP. The second peak is predominantly caused by the impedance mismatch within the 75 arterial segments, rather than by peripheral reflections.

  18. Stiffness of Railway Soil-Steel Structures

    NASA Astrophysics Data System (ADS)

    Machelski, Czesław

    2015-12-01

    The considerable influence of the soil backfill properties and that of the method of compacting it on the stiffness of soil-steel structures is characteristic of the latter. The above factors (exhibiting randomness) become apparent in shell deformation measurements conducted during construction and proof test loading. A definition of soil-shell structure stiffness, calculated on the basis of shell deflection under the service load, is proposed in the paper. It is demonstrated that the stiffness is the inverse of the deflection influence function used in structural mechanics. The moving load methodology is shown to be useful for testing, since it makes it possible to map the shell deflection influence line also in the case of group loads (concentrated forces), as in bridges. The analyzed cases show that the shell's span, geometry (static scheme) and the height of earth fill influence the stiffness of the structure. The soil-steel structure's characteristic parameter in the form of stiffness k is more suitable for assessing the quality of construction works than the proposed in code geometric index ω applied to beam structures. As shown in the given examples, parameter k is more effective than stiffness parameter λ used to estimate the deformation of soil-steel structures under construction. Although the examples concern railway structures, the methodology proposed in the paper is suitable also for road bridges.

  19. A unit-cell model of textile composite beams for predicting stiffness properties

    NASA Technical Reports Server (NTRS)

    Sankar, Bhavani V.; Marrey, Ramesh V.

    1993-01-01

    Flexural stiffness properties of a textile composite beam are obtained from a finite-element model of the unit cell. Three linearly independent deformations, namely, pure extension, pure bending and pure shear, are applied to the unit cell. The top and bottom surfaces of the beam are assumed to be traction free. Periodic boundary conditions on the lateral boundaries of the unit cell are enforced by multi-point constraint elements. From the forces acting on the unit cell, the flexural stiffness coefficients of the composite beam are obtained. The difficulties in determining the transverse shear stiffness are discussed, and a modified approach is presented. The methods are first verified by applying them to isotropic and bimaterial beams for which the results are known, and then illustrated for a simple plain-weave textile composite.

  20. Design of a variable-stiffness robotic hand using pneumatic soft rubber actuators

    NASA Astrophysics Data System (ADS)

    Nagase, Jun-ya; Wakimoto, Shuichi; Satoh, Toshiyuki; Saga, Norihiko; Suzumori, Koichi

    2011-10-01

    In recent years, Japanese society has been ageing, engendering a labor shortage of young workers. Robots are therefore expected to be useful in performing tasks such as day-to-day support for elderly people. In particular, robots that are intended for use in the field of medical care and welfare are expected to be safe when operating in a human environment because they often come into contact with people. Furthermore, robots must perform various tasks such as regrasping, grasping of soft objects, and tasks using frictional force. Given these demands and circumstances, a tendon-driven robot hand with a stiffness changing finger has been developed. The finger surface stiffness can be altered by adjusting the input pressure depending on the task. Additionally, the coefficient of static friction can be altered by changing the surface stiffness merely by adjusting the input air pressure. This report describes the basic structure, driving mechanism, and basic properties of the proposed robot hand.

  1. Commentary on Coefficient Alpha: A Cautionary Tale

    ERIC Educational Resources Information Center

    Green, Samuel B.; Yang, Yanyun

    2009-01-01

    The general use of coefficient alpha to assess reliability should be discouraged on a number of grounds. The assumptions underlying coefficient alpha are unlikely to hold in practice, and violation of these assumptions can result in nontrivial negative or positive bias. Structural equation modeling was discussed as an informative process both to…

  2. Conformational Analysis of Stiff Chiral Polymers with End-Constraints

    PubMed Central

    Kim, Jin Seob; Chirikjian, Gregory S.

    2010-01-01

    We present a Lie-group-theoretic method for the kinematic and dynamic analysis of chiral semi-flexible polymers with end constraints. The first is to determine the minimum energy conformations of semi-flexible polymers with end constraints, and the second is to perform normal mode analysis based on the determined minimum energy conformations. In this paper, we use concepts from the theory of Lie groups and principles of variational calculus to model such polymers as inextensible or extensible chiral elastic rods with coupling between twisting and bending stiffnesses, and/or between twisting and extension stiffnesses. This method is general enough to include any stiffness and chirality parameters in the context of elastic filament models with the quadratic elastic potential energy function. As an application of this formulation, the analysis of DNA conformations is discussed. We demonstrate our method with examples of DNA conformations in which topological properties such as writhe, twist, and linking number are calculated from the results of the proposed method. Given these minimum energy conformations, we describe how to perform the normal mode analysis. The results presented here build both on recent experimental work in which DNA mechanical properties have been measured, and theoretical work in which the mechanics of non-chiral elastic rods has been studied. PMID:20198114

  3. Experimental exposure to diesel exhaust increases arterial stiffness in man

    PubMed Central

    Lundbäck, Magnus; Mills, Nicholas L; Lucking, Andrew; Barath, Stefan; Donaldson, Ken; Newby, David E; Sandström, Thomas; Blomberg, Anders

    2009-01-01

    Introduction Exposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial pressure and left ventricular after-load. We determined the effect of diesel exhaust exposure on arterial compliance using a validated non-invasive measure of arterial stiffness. Methods In a double-blind randomized fashion, 12 healthy volunteers were exposed to diesel exhaust (approximately 350 μg/m3) or filtered air for one hour during moderate exercise. Arterial stiffness was measured using applanation tonometry at the radial artery for pulse wave analysis (PWA), as well as at the femoral and carotid arteries for pulse wave velocity (PWV). PWA was performed 10, 20 and 30 min, and carotid-femoral PWV 40 min, post-exposure. Augmentation pressure (AP), augmentation index (AIx) and time to wave reflection (Tr) were calculated. Results Blood pressure, AP and AIx were generally low reflecting compliant arteries. In comparison to filtered air, diesel exhaust exposure induced an increase in AP of 2.5 mmHg (p = 0.02) and in AIx of 7.8% (p = 0.01), along with a 16 ms reduction in Tr (p = 0.03), 10 minutes post-exposure. Conclusion Acute exposure to diesel exhaust is associated with an immediate and transient increase in arterial stiffness. This may, in part, explain the increased risk for cardiovascular disease associated with air pollution exposure. If our findings are confirmed in larger cohorts of susceptible populations, this simple non-invasive method of assessing arterial stiffness may become a useful technique in measuring the impact of real world exposures to combustion derived-air pollution. PMID:19284640

  4. Stiff-person syndrome with amphiphysin antibodies

    PubMed Central

    Murinson, Beth B.; Guarnaccia, Joseph B.

    2008-01-01

    Background: Stiff-person syndrome (SPS), formerly Stiff-man syndrome, is a rare autoimmune disease usually exhibiting severe spasms and thoracolumbar stiffness, with very elevated glutamic acid decarboxylase antibodies (GAD Ab). A paraneoplastic variant, less well characterized, is associated with amphiphysin antibodies (amphiphysin Ab). The objective of this study was to identify distinctive clinical features of amphiphysin Ab-associated SPS. Methods: Records associated with 845 sera tested in the Yale SPS project were examined, and 621 patients with clinically suspected SPS were included in the study. Clinical characteristics were assessed with correction for multiple comparisons. Results: In all, 116 patients had GAD antibodies and 11 patients had amphiphysin Ab; some clinical information was available for 112 and 11 of these patients, respectively. Patients with amphiphysin Ab-associated SPS were exclusively female; mean age was 60. All except one had breast cancer; none had diabetes. Compared to patients with GAD Ab-associated SPS, those with amphiphysin Ab were older (p = 0.02) and showed a dramatically different stiffness pattern (p < 0.0000001) with cervical involvement more likely, p ≤ 0.001. Electromyography showed continuous motor unit activity or was reported positive in eight. Benzodiazepines at high dose (average 50 mg/day diazepam) were partially effective. Four patients were steroid responsive and tumor excision with chemotherapy produced marked clinical improvement in three of five patients. Conclusions: Amphiphysin Ab-associated stiff-person syndrome is strongly associated with cervical region stiffness, female sex, breast cancer, advanced age, EMG abnormalities, and benzodiazepine responsiveness. The condition may respond to steroids and can dramatically improve with cancer treatment. GLOSSARY EAE = experimental autoimmune encephalitis; GAD Ab = glutamic acid decarboxylase antibodies; ICC = immunocytochemistry; PERM = progressive variant with

  5. Assessments of endothelial function and arterial stiffness are reproducible in patients with COPD

    PubMed Central

    Rodriguez-Miguelez, Paula; Seigler, Nichole; Bass, Leon; Dillard, Thomas A; Harris, Ryan A

    2015-01-01

    Background Elevated cardiovascular disease risk is observed in patients with COPD. Non-invasive assessments of endothelial dysfunction and arterial stiffness have recently emerged to provide mechanistic insight into cardiovascular disease risk in COPD; however, the reproducibility of endothelial function and arterial stiffness has yet to be investigated in this patient population. Objectives This study sought to examine the within-day and between-day reproducibility of endothelial function and arterial stiffness in patients with COPD. Methods Baseline diameter, peak diameter, flow-mediated dilation, augmentation index, augmentation index at 75 beats per minute, and pulse wave velocity were assessed three times in 17 patients with COPD (six males, eleven females, age range 47–75 years old; forced expiratory volume in 1 second =51.5% predicted). Session A and B were separated by 3 hours (within-day), whereas session C was conducted at least 7 days following session B (between-day). Reproducibility was assessed by: 1) paired t-tests, 2) coefficients of variation, 3) coefficients of variation prime, 4) intra-class correlation coefficient, 5) Pearson’s correlations (r), and 6) Bland–Altman plots. Five acceptable assessments were required to confirm reproducibility. Results Six out of six within-day criteria were met for endothelial function and arterial stiffness outcomes. Six out of six between-day criteria were met for baseline and peak diameter, augmentation index and pulse wave velocity, whereas five out of six criteria were met for flow-mediated dilation. Conclusion The present study provides evidence for within-day and between-day reproducibility of endothelial function and arterial stiffness in patients with COPD. PMID:26396509

  6. Ultrasonic measurements of stiffness in thermal-mechanically fatigued IM7/5260 composites

    SciTech Connect

    Seale, M.D.; Madaras, E.I. )

    1999-08-01

    In recent years, ultrasonic methods have been developed that can measure the mechanical stiffness of composites. The Lamb wave velocity is directly related to the material parameters, so an effective method exists to ascertain the stiffness of composites by measuring the velocity of these waves. In this study, a Lamb wave measurement system was used to measure the bending and out-of-plane stiffness coefficients of thermoset composite laminates undergoing thermal-mechanical loading. A series of 16 ply and 32 ply composite laminates were subjected to thermal-mechanical fatigue (TMF) in load frames equipped with special environmental chambers. The composite system studied was a graphite fiber-reinforced bismaleimide thermoset, IM7/5260. The samples were subjected to both high and low temperature profiles as well as high-strain and low-strain profiles. The bending and out-of-plane stiffnesses for composite samples that have undergone over 6,000 cycles of combined thermal and mechanical fatigue are reported. The Lamb wave generated elastic stiffness results have shown decreases of up to 64% at 4,706 cycles for samples subjected to TMF at high temperatures and less than a 10% decrease at over 6,000 cycles for samples subjected to TMF at low temperatures.

  7. Diamond's elastic stiffnesses from 322 K to 10 K

    NASA Astrophysics Data System (ADS)

    Migliori, Albert; Ledbetter, Hassel; Leisure, Robert G.; Pantea, C.; Betts, J. B.

    2008-09-01

    Using resonant-ultrasound spectroscopy, we measured diamond's monocrystal elastic-stiffness coefficients C11, C12, and C44, between 322 and 10 K. Changes are small and smooth: The bulk modulus B =(C11+2C12)/3 increases about 1 part in 1000, describable by a quasiharmonic Einstein-oscillator model. Zero-temperature Cij correspond to a 2244-K Debye characteristic temperature. Using a low-temperature form of the Grüneisen-Debye model, we calculated an overall thermodynamic Grüneisen parameter of γ =1.26; using a high-temperature form we calculated 0.71; the lattice specific heat yields γ =1.10.

  8. Quantitative Elastography for Cervical Stiffness Assessment during Pregnancy

    PubMed Central

    Fruscalzo, A.; Londero, A. P.; Fröhlich, C.; Möllmann, U.; Schmitz, R.

    2014-01-01

    Aim. Feasibility and reliability of tissue Doppler imaging-(TDI-) based elastography for cervical quantitative stiffness assessment during all three trimesters of pregnancy were evaluated. Materials and Methods. Prospective case-control study including seventy-four patients collected between the 12th and 42nd weeks of gestation. The tissue strain (TS) was measured by two independent operators as natural strain. Intra- and interoperator intraclass correlation coefficient (ICC) agreements were evaluated. Results. TS measurement was always feasible and exhibited a high performance in terms of reliability (intraoperator ICC-agreement = 0.93; interoperator ICC agreement = 0.89 and 0.93 for a single measurement and for the average of two measurements, resp.). Cervical TS showed also a significant correlation with gestational age, cervical length, and parity. Conclusions. TS measurement during pregnancy demonstrated high feasibility and reliability. Furthermore, TS significantly correlated with gestational age, cervical length, and parity. PMID:24734246

  9. Leg stiffness: comparison between unilateral and bilateral hopping tasks.

    PubMed

    Brauner, Torsten; Sterzing, Thorsten; Wulf, Mathias; Horstmann, Thomas

    2014-02-01

    Leg stiffness is a predictor of athletic performance and injury and typically evaluated during bilateral hopping. The contribution of each limb to bilateral leg stiffness, however, is not well understood. This study investigated leg stiffness during unilateral and bilateral hopping to address the following research questions: (1) does the magnitude and variability of leg stiffness differ between dominant and non-dominant legs? (2) Does unilateral leg stiffness differ from bilateral leg stiffness? and (3) Is bilateral leg stiffness determined by unilateral leg stiffness? Thirty-two physically active males performed repeated hopping tests on a force platform for each of the three conditions: bilateral hopping, unilateral hopping on the dominant leg, and unilateral hopping on the non-dominant leg. Leg stiffness was estimated as the ratio of the peak vertical force and the maximum displacement using a simple 1-D mass-spring model. Neither the magnitude nor variability of leg stiffness differed between dominant and non-dominant limbs. Unilateral leg stiffness was 24% lower than bilateral stiffness and showed less variability between consecutive hops and subjects. Unilateral leg stiffness explained 76% of the variance in bilateral leg stiffness. We conclude that leg stiffness estimates during unilateral hopping are preferable for intervention studies because of their low variability. PMID:24290613

  10. Hyper-damping properties of a stiff and stable linear oscillator with a negative stiffness element

    NASA Astrophysics Data System (ADS)

    Antoniadis, I.; Chronopoulos, D.; Spitas, V.; Koulocheris, D.

    2015-06-01

    A simple, stiff, statically and dynamically stable linear oscillator incorporating a negative stiffness element is used as a template to provide a generic theoretical basis for a novel vibration damping and isolation concept. This oscillator is designed to present the same overall static stiffness, the same mass and to use the same damping element as a reference classical linear SDoF oscillator. Thus, no increase of the structure mass or the viscous damping is needed, as in the case of a traditional linear isolator, no decrease of the overall structure stiffness is required as in the case of 'zero-stiffness' oscillators with embedded negative stiffness elements. The difference from these two templates consists entirely in the proper redistribution and reallocation of the stiffness and the damping elements of the system. Once such an oscillator is optimally designed, it is shown to exhibit an extraordinary apparent damping ratio, which is even several orders of magnitude higher than that of the original SDoF system, especially in cases where the original damping of the SDoF system is extremely low. This extraordinary damping behavior is a result of the phase difference between the positive and the negative stiffness elastic forces, which is in turn a consequence of the proper redistribution of the stiffness and the damping elements. This fact ensures that an adequate level of elastic forces exists throughout the entire frequency range, able to counteract the inertial and the excitation forces. Consequently, a resonance phenomenon, which is inherent in the original linear SDoF system, cannot emerge in the proposed oscillator. The optimal parameter selection for the design of the negative stiffness oscillator is discussed. To further exhibit the advantages that such a design can generate, the suggested oscillator is implemented within a periodic acoustic metamaterial structure, inducing a radical increase in the damping of the propagating acoustic waves. The concept

  11. Immediate effects of kinematic taping on lower extremity muscle tone and stiffness in flexible flat feet

    PubMed Central

    Wang, Joong-San; Um, Gi-Mai; Choi, Jung-Hyun

    2016-01-01

    [Purpose] This study aimed to examine the immediate effects of kinematic taping on the tone and stiffness in the leg muscles of subjects with flexible flat feet. [Subjects and Methods] A total of 30 subjects, 15 in the kinematic taping and 15 in the sham taping group, were administered respective taping interventions. Subsequently, the foot pressure and the tone and stiffness in the tibialis anterior, rectus femoris, medial gastrocnemius, and the long head of the biceps femoris muscles of both the lower extremities were measured. [Results] The foot pressure of the dominant leg significantly decreased in the kinematic taping group. The muscle tone and stiffness in the rectus femoris muscle of the dominant and non-dominant leg, tibialis anterior muscle of the dominant leg, medial gastrocnemius muscle of the non-dominant leg, and the stiffness in the dominant leg significantly decreased. The muscle tone and stiffness generally increased in the sham taping group. However, no significant difference was observed between the 2 groups. [Conclusion] This study demonstrated that kinematic taping on flexible flat feet had positive effects of immediately reducing the abnormally increased foot pressure and the tone and stiffness in the lower extremity muscles. PMID:27190479

  12. A novel magnetorheological elastomer isolator with negative changing stiffness for vibration reduction

    NASA Astrophysics Data System (ADS)

    Yang, J.; Sun, S. S.; Du, H.; Li, W. H.; Alici, G.; Deng, H. X.

    2014-10-01

    Magneto-rheological elastomers (MREs) have attracted notable credits in the development of smart isolators and absorbers due to their controllable stiffness and damping properties. For the purpose of mitigating unwanted structural and/or machinery vibrations, the traditional MRE-based isolators have been generally proven effective because the MR effect can increase the stiffness when the magnetic field is strengthened. This study presents a novel MRE isolator that experienced reduced stiffness when the applied current was increased. This innovative work was accomplished by applying a hybrid magnet (electromagnet and permanent magnets) onto a multilayered MRE structure. To characterise this negative changing stiffness concept, a multilayered MRE isolator with a hybrid magnet was first designed, fabricated and then tested to measure its properties. An obvious reduction of the effective stiffness and natural frequency of the proposed MRE isolator occurred when the current was continuously adjusted. This device could also work as a conventional MRE isolator as its effective stiffness and natural frequency also increased when a negative current was applied. Further testing was carried out on a one-degree-of-freedom system to assess how effectively this device could isolate vibration. In this experiment, two cases were considered; in each case, the vibration of the primary system was obviously attenuated under ON-OFF control logic, thus demonstrating the feasibility of this novel design as an alternative adaptive vibration isolator.

  13. Numerically Generated Tangent Stiffness Matrices for Geometrically Non-Linear Structures

    NASA Astrophysics Data System (ADS)

    Lebofsky, Sonia

    The aim of this thesis is to develop a general numerical solution method for geometrically non-linear structures. Most common work involves tedious derivations of analytic tangent stiffness matrices. The major objective of the current work is to develop a numerically generated tangent stiffness matrix that allows for a general and easily implementable solution method. The thesis begins with the definition of the tangent stiffness matrix and a discussion of the Newton-Raphson incremental-iterative method typically used to solve geometrically non-linear problems. This is followed by a detailed description of how the tangent stiffness matrix is numerically generated using complex variable differentiation to approximate sensitivities. The thesis proceeds with details of the solution method applied to three different structural elements: 3D truss, membrane, and 3D beam. These discussions include numeric examples for each type of structure, the results of which are compared with the literature and ANSYS solutions. The results from the present work show that solutions obtained using the general numerically generated tangent stiffness matrix are accurate. While computational effort is increased, the method is especially attractive in the context of research involving small finite element models.

  14. Running with a load increases leg stiffness.

    PubMed

    Silder, Amy; Besier, Thor; Delp, Scott L

    2015-04-13

    Spring-mass models have been used to characterize running mechanics and leg stiffness in a variety of conditions, yet it remains unknown how running while carrying a load affects running mechanics and leg stiffness. The purpose of this study was to test the hypothesis that running with a load increases leg stiffness. Twenty-seven subjects ran at a constant speed on a force-measuring treadmill while carrying no load, and while wearing weight vests loaded with 10%, 20%, and 30% of body weight. We measured lower extremity motion and created a scaled musculoskeletal model of each subject, which we used to estimate lower extremity joint angles and leg length. We estimated dimensionless leg stiffness as the ratio of the peak vertical ground reaction force (normalized to body weight) and the change in stance phase leg length (normalized to leg length at initial foot contact). Leg length was calculated as the distance from the center of the pelvis to the center-of-pressure under the foot. We found that dimensionless leg stiffness increased when running with load (p=0.001); this resulted from an increase in the peak vertical ground reaction force (p<0.001) and a smaller change in stance phase leg length (p=0.025). When running with load, subjects had longer ground contact times (p<0.020), greater hip (p<0.001) and knee flexion (p=0.048) at the time of initial foot contact, and greater peak stance phase hip, knee, and ankle flexion (p<0.05). Our results reveal that subjects run in a more crouched posture and with higher leg stiffness to accommodate an added load.

  15. Running with a load increases leg stiffness.

    PubMed

    Silder, Amy; Besier, Thor; Delp, Scott L

    2015-04-13

    Spring-mass models have been used to characterize running mechanics and leg stiffness in a variety of conditions, yet it remains unknown how running while carrying a load affects running mechanics and leg stiffness. The purpose of this study was to test the hypothesis that running with a load increases leg stiffness. Twenty-seven subjects ran at a constant speed on a force-measuring treadmill while carrying no load, and while wearing weight vests loaded with 10%, 20%, and 30% of body weight. We measured lower extremity motion and created a scaled musculoskeletal model of each subject, which we used to estimate lower extremity joint angles and leg length. We estimated dimensionless leg stiffness as the ratio of the peak vertical ground reaction force (normalized to body weight) and the change in stance phase leg length (normalized to leg length at initial foot contact). Leg length was calculated as the distance from the center of the pelvis to the center-of-pressure under the foot. We found that dimensionless leg stiffness increased when running with load (p=0.001); this resulted from an increase in the peak vertical ground reaction force (p<0.001) and a smaller change in stance phase leg length (p=0.025). When running with load, subjects had longer ground contact times (p<0.020), greater hip (p<0.001) and knee flexion (p=0.048) at the time of initial foot contact, and greater peak stance phase hip, knee, and ankle flexion (p<0.05). Our results reveal that subjects run in a more crouched posture and with higher leg stiffness to accommodate an added load. PMID:25728581

  16. Stability with large step sizes for multistep discretizations of stiff ordinary differential equations

    NASA Technical Reports Server (NTRS)

    Majda, George

    1986-01-01

    One-leg and multistep discretizations of variable-coefficient linear systems of ODEs having both slow and fast time scales are investigated analytically. The stability properties of these discretizations are obtained independent of ODE stiffness and compared. The results of numerical computations are presented in tables, and it is shown that for large step sizes the stability of one-leg methods is better than that of the corresponding linear multistep methods.

  17. Elastic Stiffness of a Skyrmion Crystal

    NASA Astrophysics Data System (ADS)

    Nii, Y.; Kikkawa, A.; Taguchi, Y.; Tokura, Y.; Iwasa, Y.

    2014-12-01

    We observe the elastic stiffness and ultrasonic absorption of a Skyrmion crystal in the chiral-lattice magnet MnSi. The Skyrmion crystal lattice exhibits a stiffness 3 orders of magnitude smaller than that of the atomic lattice of MnSi, being as soft as the flux line lattice in type-II superconductors. The observed anisotropic elastic responses are consistent with the cylindrical shape of the Skyrmion spin texture. Phenomenological analysis reveals that the spin-orbit coupling is responsible for the emergence of anisotropic elasticity in the Skyrmion lattice.

  18. Identifying Bearing Rotodynamic Coefficients Using an Extended Kalman Filter

    NASA Technical Reports Server (NTRS)

    Miller, Brad A.; Howard, Samuel A.

    2008-01-01

    An Extended Kalman Filter is developed to estimate the linearized direct and indirect stiffness and damping force coefficients for bearings in rotor dynamic applications from noisy measurements of the shaft displacement in response to imbalance and impact excitation. The bearing properties are modeled as stochastic random variables using a Gauss-Markov model. Noise terms are introduced into the system model to account for all of the estimation error, including modeling errors and uncertainties and the propagation of measurement errors into the parameter estimates. The system model contains two user-defined parameters that can be tuned to improve the filter's performance; these parameters correspond to the covariance of the system and measurement noise variables. The filter is also strongly influenced by the initial values of the states and the error covariance matrix. The filter is demonstrated using numerically simulated data for a rotor bearing system with two identical bearings, which reduces the number of unknown linear dynamic coefficients to eight. The filter estimates for the direct damping coefficients and all four stiffness coefficients correlated well with actual values, whereas the estimates for the cross-coupled damping coefficients were the least accurate.

  19. Identifying Bearing Rotordynamic Coefficients using an Extended Kalman Filter

    NASA Technical Reports Server (NTRS)

    Miller, Brad A.; Howard, Samuel A.

    2008-01-01

    An Extended Kalman Filter is developed to estimate the linearized direct and indirect stiffness and damping force coefficients for bearings in rotor-dynamic applications from noisy measurements of the shaft displacement in response to imbalance and impact excitation. The bearing properties are modeled as stochastic random variables using a Gauss-Markov model. Noise terms are introduced into the system model to account for all of the estimation error, including modeling errors and uncertainties and the propagation of measurement errors into the parameter estimates. The system model contains two user-defined parameters that can be tuned to improve the filter s performance; these parameters correspond to the covariance of the system and measurement noise variables. The filter is also strongly influenced by the initial values of the states and the error covariance matrix. The filter is demonstrated using numerically simulated data for a rotor-bearing system with two identical bearings, which reduces the number of unknown linear dynamic coefficients to eight. The filter estimates for the direct damping coefficients and all four stiffness coefficients correlated well with actual values, whereas the estimates for the cross-coupled damping coefficients were the least accurate.

  20. Cancer Cell Stiffness: Integrated Roles of Three-Dimensional Matrix Stiffness and Transforming Potential

    PubMed Central

    Baker, Erin L.; Lu, Jing; Yu, Dihua; Bonnecaze, Roger T.; Zaman, Muhammad H.

    2010-01-01

    While significant advances have been made toward revealing the molecular mechanisms that influence breast cancer progression, much less is known about the associated cellular mechanical properties. To this end, we use particle-tracking microrheology to investigate the interplay among intracellular mechanics, three-dimensional matrix stiffness, and transforming potential in a mammary epithelial cell (MEC) cancer progression series. We use a well-characterized model system where human-derived MCF10A MECs overexpress either ErbB2, 14-3-3ζ, or both ErbB2 and 14-3-3ζ, with empty vector as a control. Our results show that MECs possessing ErbB2 transforming potential stiffen in response to elevated matrix stiffness, whereas non-transformed MECs or those overexpressing only 14-3-3ζ do no exhibit this response. We further observe that overexpression of ErbB2 alone is associated with the highest degree of intracellular sensitivity to matrix stiffness, and that the effect of transforming potential on intracellular stiffness is matrix-stiffness-dependent. Moreover, our intracellular stiffness measurements parallel cell migration behavior that has been previously reported for these MEC sublines. Given the current knowledge base of breast cancer mechanobiology, these findings suggest that there may be a positive relationship among intracellular stiffness sensitivity, cell motility, and perturbed mechanotransduction in breast cancer. PMID:20923638

  1. Cancer cell stiffness: integrated roles of three-dimensional matrix stiffness and transforming potential.

    PubMed

    Baker, Erin L; Lu, Jing; Yu, Dihua; Bonnecaze, Roger T; Zaman, Muhammad H

    2010-10-01

    While significant advances have been made toward revealing the molecular mechanisms that influence breast cancer progression, much less is known about the associated cellular mechanical properties. To this end, we use particle-tracking microrheology to investigate the interplay among intracellular mechanics, three-dimensional matrix stiffness, and transforming potential in a mammary epithelial cell (MEC) cancer progression series. We use a well-characterized model system where human-derived MCF10A MECs overexpress either ErbB2, 14-3-3ζ, or both ErbB2 and 14-3-3ζ, with empty vector as a control. Our results show that MECs possessing ErbB2 transforming potential stiffen in response to elevated matrix stiffness, whereas non-transformed MECs or those overexpressing only 14-3-3ζ do no exhibit this response. We further observe that overexpression of ErbB2 alone is associated with the highest degree of intracellular sensitivity to matrix stiffness, and that the effect of transforming potential on intracellular stiffness is matrix-stiffness-dependent. Moreover, our intracellular stiffness measurements parallel cell migration behavior that has been previously reported for these MEC sublines. Given the current knowledge base of breast cancer mechanobiology, these findings suggest that there may be a positive relationship among intracellular stiffness sensitivity, cell motility, and perturbed mechanotransduction in breast cancer.

  2. Effects of Interlayer Interfacial Stiffness on Ultrasonic Wave Propagation in Composite Laminates at Oblique Incidence

    NASA Astrophysics Data System (ADS)

    Ishii, Yosuke; Biwa, Shiro

    The transmission characteristics of ultrasonic wave impinging obliquely on composite laminates are analyzed. Incorporating the influence of thin resin-rich regions between adjacent plies by spring-type interfaces, the amplitude transmission coefficient of a unidirectional composite laminate immersed in water is calculated by the stiffness-matrix method. Using Floquet's theorem, the dispersion relation for the infinitely laminated structure is also calculated. Comparison between two results reveals that the frequency band-gaps in the dispersion relation agree well with the low-transmission frequency ranges of the finite laminated case. Comparing with the experimental transmission coefficients for an 11-ply carbon-epoxy composite laminate, the theoretical results are verified.

  3. Steel Rack Connections: Identification of Most Influential Factors and a Comparison of Stiffness Design Methods.

    PubMed

    Shah, S N R; Sulong, N H Ramli; Shariati, Mahdi; Jumaat, M Z

    2015-01-01

    Steel pallet rack (SPR) beam-to-column connections (BCCs) are largely responsible to avoid the sway failure of frames in the down-aisle direction. The overall geometry of beam end connectors commercially used in SPR BCCs is different and does not allow a generalized analytic approach for all types of beam end connectors; however, identifying the effects of the configuration, profile and sizes of the connection components could be the suitable approach for the practical design engineers in order to predict the generalized behavior of any SPR BCC. This paper describes the experimental behavior of SPR BCCs tested using a double cantilever test set-up. Eight sets of specimens were identified based on the variation in column thickness, beam depth and number of tabs in the beam end connector in order to investigate the most influential factors affecting the connection performance. Four tests were repeatedly performed for each set to bring uniformity to the results taking the total number of tests to thirty-two. The moment-rotation (M-θ) behavior, load-strain relationship, major failure modes and the influence of selected parameters on connection performance were investigated. A comparative study to calculate the connection stiffness was carried out using the initial stiffness method, the slope to half-ultimate moment method and the equal area method. In order to find out the more appropriate method, the mean stiffness of all the tested connections and the variance in values of mean stiffness according to all three methods were calculated. The calculation of connection stiffness by means of the initial stiffness method is considered to overestimate the values when compared to the other two methods. The equal area method provided more consistent values of stiffness and lowest variance in the data set as compared to the other two methods. PMID:26452047

  4. Steel Rack Connections: Identification of Most Influential Factors and a Comparison of Stiffness Design Methods

    PubMed Central

    Shah, S. N. R.; Sulong, N. H. Ramli; Shariati, Mahdi; Jumaat, M. Z.

    2015-01-01

    Steel pallet rack (SPR) beam-to-column connections (BCCs) are largely responsible to avoid the sway failure of frames in the down-aisle direction. The overall geometry of beam end connectors commercially used in SPR BCCs is different and does not allow a generalized analytic approach for all types of beam end connectors; however, identifying the effects of the configuration, profile and sizes of the connection components could be the suitable approach for the practical design engineers in order to predict the generalized behavior of any SPR BCC. This paper describes the experimental behavior of SPR BCCs tested using a double cantilever test set-up. Eight sets of specimens were identified based on the variation in column thickness, beam depth and number of tabs in the beam end connector in order to investigate the most influential factors affecting the connection performance. Four tests were repeatedly performed for each set to bring uniformity to the results taking the total number of tests to thirty-two. The moment-rotation (M-θ) behavior, load-strain relationship, major failure modes and the influence of selected parameters on connection performance were investigated. A comparative study to calculate the connection stiffness was carried out using the initial stiffness method, the slope to half-ultimate moment method and the equal area method. In order to find out the more appropriate method, the mean stiffness of all the tested connections and the variance in values of mean stiffness according to all three methods were calculated. The calculation of connection stiffness by means of the initial stiffness method is considered to overestimate the values when compared to the other two methods. The equal area method provided more consistent values of stiffness and lowest variance in the data set as compared to the other two methods. PMID:26452047

  5. [Anaesthetic management of Stiff Man syndrome].

    PubMed

    Marín, T; Hernando, D; Kinast, N; Churruca, I; Sabate, S

    2015-04-01

    Stiff Man syndrome or stiff-person syndrome is a rare autoimmune disorder. It is characterized by increased axial muscular tone and limb musculature, and painful spasms triggered by stimulus. The case is presented of a 44-year-old man with stiff-person syndrome undergoing an injection of botulinum toxin in the urethral sphincter under sedation. Before induction, all the surgical team were ready in order to minimise the anaesthetic time. The patient was monitored by continuous ECG, SpO2 and non-invasive blood pressure. He was induced with fractional dose of propofol 150 mg, fentanyl 50 μg and midazolam 1mg. Despite careful titration, the patient had an O2 saturation level of 90%,which was resolved by manual ventilation. There was no muscle rigidity or spasm during the operation. Post-operative recovery was uneventful and the patient was discharged 2 days later. A review of other cases is presented. The anaesthetic concern in patients with stiff-person syndrome is the interaction between the anaesthetic agents, the preoperative medication, and the GABA system. For a safe anaesthetic management, total intravenous anaesthesia is recommended instead of inhalation anaesthetics, as well as the close monitoring of the respiratory function and the application of the electrical nerve stimulator when neuromuscular blockers are used. PMID:25060949

  6. Vibrating Beam With Spatially Periodic Stiffness

    NASA Technical Reports Server (NTRS)

    Townsend, John S.

    1989-01-01

    Report presents theoretical analysis of vibrations of simply supported beam, bending stiffness varying about steady value, sinusoidally with position along length. Problem of practical importance because related to vibrations of twisted-pair electric-power transmission lines. Twists promote nonuniform shedding of vortexes and prevents resonant accumulation of vibrational energy from wind.

  7. Elastin in large artery stiffness and hypertension.

    PubMed

    Wagenseil, Jessica E; Mecham, Robert P

    2012-06-01

    Large artery stiffness, as measured by pulse wave velocity, is correlated with high blood pressure and may be a causative factor in essential hypertension. The extracellular matrix components, specifically the mix of elastin and collagen in the vessel wall, determine the passive mechanical properties of the large arteries. Elastin is organized into elastic fibers in the wall during arterial development in a complex process that requires spatial and temporal coordination of numerous proteins. The elastic fibers last the lifetime of the organism but are subject to proteolytic degradation and chemical alterations that change their mechanical properties. This review discusses how alterations in the amount, assembly, organization, or chemical properties of the elastic fibers affect arterial stiffness and blood pressure. Strategies for encouraging or reversing alterations to the elastic fibers are addressed. Methods for determining the efficacy of these strategies, by measuring elastin amounts and arterial stiffness, are summarized. Therapies that have a direct effect on arterial stiffness through alterations to the elastic fibers in the wall may be an effective treatment for essential hypertension.

  8. Biaxial strain and variable stiffness in aponeuroses

    PubMed Central

    Azizi, Emanuel; Roberts, Thomas J

    2009-01-01

    The elastic structures of many muscles include both an extramuscular free tendon as well as a sheet-like aponeurosis. An important distinguishing feature of aponeuroses is that these tendinous structures function as the attachment and insertion surfaces of muscle fascicles and therefore surround a substantial portion of the muscle belly. As a result, aponeuroses must expand both parallel (longitudinal) and perpendicular (transverse) to a muscle's line of action when contracting muscles bulge to maintain a constant volume. In this study, we use biplanar high-speed fluoroscopy to track the strain patterns of the turkey lateral gastrocnemius aponeurosis during active and passive force production in situ. We find that the behaviour of the aponeurosis during passive force production is consistent with uniaxial loading, as aponeuroses stretch only in the longitudinal direction. By contrast, our results show that aponeuroses are stretched in both longitudinal and transverse directions during active force production and that transverse strains are on average 4 times greater than longitudinal strains. Biaxial loading of aponeuroses appears to effectively modulate longitudinal stiffness, as we find the measured stiffness in the longitudinal direction varies in proportion to transverse strain. We conclude that biaxial strain during active force production distinguishes aponeuroses from free tendons and may function to dynamically modulate stiffness along the axis of muscle force production. It is likely that consideration of strains measured only in the longitudinal direction result in an underestimation of aponeurosis stiffness as well as its capacity for elastic energy storage. PMID:19596897

  9. Substrate stiffness regulates cellular uptake of nanoparticles.

    PubMed

    Huang, Changjin; Butler, Peter J; Tong, Sheng; Muddana, Hari S; Bao, Gang; Zhang, Sulin

    2013-04-10

    Nanoparticle (NP)-bioconjugates hold great promise for more sensitive disease diagnosis and more effective anticancer drug delivery compared with existing approaches. A critical aspect in both applications is cellular internalization of NPs, which is influenced by NP properties and cell surface mechanics. Despite considerable progress in optimization of the NP-bioconjugates for improved targeting, the role of substrate stiffness on cellular uptake has not been investigated. Using polyacrylamide (PA) hydrogels as model substrates with tunable stiffness, we quantified the relationship between substrate stiffness and cellular uptake of fluorescent NPs by bovine aortic endothelial cells (BAECs). We found that a stiffer substrate results in a higher total cellular uptake on a per cell basis, but a lower uptake per unit membrane area. To obtain a mechanistic understanding of the cellular uptake behavior, we developed a thermodynamic model that predicts that membrane spreading area and cell membrane tension are two key factors controlling cellular uptake of NPs, both of which are modulated by substrate stiffness. Our experimental and modeling results not only open up new avenues for engineering NP-based cancer cell targets for more effective in vivo delivery but also contribute an example of how the physical environment dictates cellular behavior and function.

  10. [Anaesthetic management of Stiff Man syndrome].

    PubMed

    Marín, T; Hernando, D; Kinast, N; Churruca, I; Sabate, S

    2015-04-01

    Stiff Man syndrome or stiff-person syndrome is a rare autoimmune disorder. It is characterized by increased axial muscular tone and limb musculature, and painful spasms triggered by stimulus. The case is presented of a 44-year-old man with stiff-person syndrome undergoing an injection of botulinum toxin in the urethral sphincter under sedation. Before induction, all the surgical team were ready in order to minimise the anaesthetic time. The patient was monitored by continuous ECG, SpO2 and non-invasive blood pressure. He was induced with fractional dose of propofol 150 mg, fentanyl 50 μg and midazolam 1mg. Despite careful titration, the patient had an O2 saturation level of 90%,which was resolved by manual ventilation. There was no muscle rigidity or spasm during the operation. Post-operative recovery was uneventful and the patient was discharged 2 days later. A review of other cases is presented. The anaesthetic concern in patients with stiff-person syndrome is the interaction between the anaesthetic agents, the preoperative medication, and the GABA system. For a safe anaesthetic management, total intravenous anaesthesia is recommended instead of inhalation anaesthetics, as well as the close monitoring of the respiratory function and the application of the electrical nerve stimulator when neuromuscular blockers are used.

  11. 49 CFR 213.359 - Track stiffness.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher § 213.359 Track stiffness. (a) Track shall have a sufficient vertical strength to withstand the maximum vehicle loads generated at maximum permissible train speeds, cant deficiencies and surface defects. For...

  12. 49 CFR 213.359 - Track stiffness.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher § 213.359 Track stiffness. (a) Track shall have a sufficient vertical strength to withstand the maximum vehicle loads generated at maximum permissible train speeds, cant deficiencies and surface defects. For...

  13. 49 CFR 213.359 - Track stiffness.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher § 213.359 Track stiffness. (a) Track shall have a sufficient vertical strength to withstand the maximum vehicle loads generated at maximum permissible train speeds, cant deficiencies and surface defects. For...

  14. 49 CFR 213.359 - Track stiffness.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF TRANSPORTATION TRACK SAFETY STANDARDS Train Operations at Track Classes 6 and Higher § 213.359 Track stiffness. (a) Track shall have a sufficient vertical strength to withstand the maximum vehicle loads generated at maximum permissible train speeds, cant deficiencies and surface defects. For...

  15. Measuring Seebeck Coefficient

    NASA Technical Reports Server (NTRS)

    Snyder, G. Jeffrey (Inventor)

    2015-01-01

    A high temperature Seebeck coefficient measurement apparatus and method with various features to minimize typical sources of errors is described. Common sources of temperature and voltage measurement errors which may impact accurate measurement are identified and reduced. Applying the identified principles, a high temperature Seebeck measurement apparatus and method employing a uniaxial, four-point geometry is described to operate from room temperature up to 1300K. These techniques for non-destructive Seebeck coefficient measurements are simple to operate, and are suitable for bulk samples with a broad range of physical types and shapes.

  16. Assessment of impact factors on shear wave based liver stiffness measurement.

    PubMed

    Ling, Wenwu; Lu, Qiang; Quan, Jierong; Ma, Lin; Luo, Yan

    2013-02-01

    Shear wave based ultrasound elastographies have been implemented as non-invasive methods for quantitative assessment of liver stiffness. Nonetheless, there are only a few studies that have investigated impact factors on liver stiffness measurement (LSM). Moreover, standard examination protocols for LSM are still lacking in clinical practice. Our study aimed to assess the impact factors on LSM to establish its standard examination protocols in clinical practice. We applied shear wave based elastography point quantification (ElastPQ) in 21 healthy individuals to determine the impact of liver location (segments I-VIII), breathing phase (end-inspiration and end-expiration), probe position (sub-costal and inter-costal position) and examiner on LSM. Additional studies in 175 healthy individuals were also performed to determine the influence of gender and age on liver stiffness. We found significant impact of liver location on LSM, while the liver segment V displayed the lowest coefficient of variation (CV 21%). The liver stiffness at the end-expiration was significantly higher than that at the end-inspiration (P=2.1E-05). The liver stiffness was 8% higher in men than in women (3.8 ± 0.7 kPa vs. 3.5 ± 0.4 kPa, P=0.0168). In contrast, the liver stiffness was comparable in the different probe positions, examiners and age groups (P>0.05). In conclusion, this study reveals significant impact from liver location, breathing phase and gender on LSM, while furthermore strengthening the necessity for the development of standard examination protocols on LSM.

  17. Lamb Wave Stiffness Characterization of Composites Undergoing Thermal-Mechanical Aging

    NASA Technical Reports Server (NTRS)

    Seale, Michael D.; Madaras, Eric I.

    2004-01-01

    The introduction of new, advanced composite materials into aviation systems requires a thorough understanding of the long term effects of combined thermal and mechanical loading upon those materials. Analytical methods investigating the effects of intense thermal heating combined with mechanical loading have been investigated. The damage mechanisms and fatigue lives were dependent on test parameters as well as stress levels. Castelli, et al. identified matrix dominated failure modes for out-of-phase cycling and fiber dominated damage modes for in-phase cycling. In recent years, ultrasonic methods have been developed that can measure the mechanical stiffness of composites. To help evaluate the effect of aging, a suitably designed Lamb wave measurement system is being used to obtain bending and out-of-plane stiffness coefficients of composite laminates undergoing thermal-mechanical loading. The system works by exciting an antisymmetric Lamb wave and calculating the velocity at each frequency from the known transducer separation and the measured time-of-flight. The same peak in the waveforms received at various distances is used to measure the time difference between the signals. The velocity measurements are accurate and repeatable to within 1% resulting in reconstructed stiffness values repeatable to within 4%. Given the material density and plate thickness, the bending and out-of-plane shear stiffnesses are calculated from a reconstruction of the dispersion curve. A mechanical scanner is used to move the sensors over the surface to map the time-of-flight, velocity, or stiffnesses of the entire specimen. Access to only one side of the material is required and no immersion or couplants are required because the sensors are dry coupled to the surface of the plate. In this study, the elastic stiffnesses D(sub 11), D(sub 22), A(sub 44), and A(sub 55) as well as time-of-flight measurements for composite samples that have undergone combined thermal and mechanical aging for

  18. Ionization coefficients in gas mixtures

    NASA Astrophysics Data System (ADS)

    Marić, D.; Šašić, O.; Jovanović, J.; Radmilović-Rađenović, M.; Petrović, Z. Lj.

    2007-03-01

    We have tested the application of the common E/N ( E—electric field, N—gas number density) or Wieland approximation [Van Brunt, R.J., 1987. Common parametrizations of electron transport, collision cross section, and dielectric strength data for binary gas mixtures. J. Appl. Phys. 61 (5), 1773-1787.] and the common mean energy (CME) combination of the data for pure gases to obtain ionization coefficients for mixtures. Test calculations were made for Ar-CH4, Ar-N2, He-Xe and CH4-N2 mixtures. Standard combination procedure gives poor results in general, due to the fact that the electron energy distribution is considerably different in mixtures and in individual gases at the same values of E/N. The CME method may be used for mixtures of gases with ionization coefficients that do not differ by more than two orders of magnitude which is better than any other technique that was proposed [Marić, D., Radmilović-Rađenović, M., Petrović, Z.Lj., 2005. On parametrization and mixture laws for electron ionization coefficients. Eur. Phys. J. D 35, 313-321.].

  19. Extending the Constant Coefficient Solution Technique to Variable Coefficient Ordinary Differential Equations

    ERIC Educational Resources Information Center

    Mohammed, Ahmed; Zeleke, Aklilu

    2015-01-01

    We introduce a class of second-order ordinary differential equations (ODEs) with variable coefficients whose closed-form solutions can be obtained by the same method used to solve ODEs with constant coefficients. General solutions for the homogeneous case are discussed.

  20. On the determination of the coefficients of the Gaussian general theory of the Earth's magnetism for the year 1885 and about the relationship of the three Earth-magnetic elements

    NASA Technical Reports Server (NTRS)

    Fritsche, H.

    1983-01-01

    An attempt is made to judge the value of the Gaussian series for the Earth's magnetism. The computation employed to do this uses the method of the least and greatest coefficients. The number of unknown which had to be calculated from the individual groups was at most only four. All symbols of Gauss were retained.

  1. A review on in situ stiffness adjustment methods in MEMS

    NASA Astrophysics Data System (ADS)

    de Laat, M. L. C.; Pérez Garza, H. H.; Herder, J. L.; Ghatkesar, M. K.

    2016-06-01

    In situ stiffness adjustment in microelectromechanical systems is used in a variety of applications such as radio-frequency mechanical filters, energy harvesters, atomic force microscopy, vibration detection sensors. In this review we provide designers with an overview of existing stiffness adjustment methods, their working principle, and possible adjustment range. The concepts are categorized according to their physical working principle. It is concluded that the electrostatic adjustment principle is the most applied method, and narrow to wide ranges in stiffness can be achieved. But in order to obtain a wide range in stiffness change, large, complex devices were designed. Mechanical stiffness adjustment is found to be a space-effective way of obtaining wide changes in stiffness, but these methods are often discrete and require large tuning voltages. Stiffness adjustment through stressing effects or change in Young’s modulus was used only for narrow ranges. The change in second moment of inertia was used for stiffness adjustment in the intermediate range.

  2. Inferences on the common coefficient of variation.

    PubMed

    Tian, Lili

    2005-07-30

    The coefficient of variation is often used as a measure of precision and reproducibility of data in medical and biological science. This paper considers the problem of making inference about the common population coefficient of variation when it is a priori suspected that several independent samples are from populations with a common coefficient of variation. The procedures for confidence interval estimation and hypothesis testing are developed based on the concepts of generalized variables. The coverage properties of the proposed confidence intervals and type-I errors of the proposed tests are evaluated by simulation. The proposed methods are illustrated by a real life example.

  3. Estimation of Quasi-Stiffness of the Human Hip in the Stance Phase of Walking

    PubMed Central

    Shamaei, Kamran; Sawicki, Gregory S.; Dollar, Aaron M.

    2013-01-01

    This work presents a framework for selection of subject-specific quasi-stiffness of hip orthoses and exoskeletons, and other devices that are intended to emulate the biological performance of this joint during walking. The hip joint exhibits linear moment-angular excursion behavior in both the extension and flexion stages of the resilient loading-unloading phase that consists of terminal stance and initial swing phases. Here, we establish statistical models that can closely estimate the slope of linear fits to the moment-angle graph of the hip in this phase, termed as the quasi-stiffness of the hip. Employing an inverse dynamics analysis, we identify a series of parameters that can capture the nearly linear hip quasi-stiffnesses in the resilient loading phase. We then employ regression analysis on experimental moment-angle data of 216 gait trials across 26 human adults walking over a wide range of gait speeds (0.75–2.63 m/s) to obtain a set of general-form statistical models that estimate the hip quasi-stiffnesses using body weight and height, gait speed, and hip excursion. We show that the general-form models can closely estimate the hip quasi-stiffness in the extension (R2 = 92%) and flexion portions (R2 = 89%) of the resilient loading phase of the gait. We further simplify the general-form models and present a set of stature-based models that can estimate the hip quasi-stiffness for the preferred gait speed using only body weight and height with an average error of 27% for the extension stage and 37% for the flexion stage. PMID:24349136

  4. Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease

    PubMed Central

    Fung, James; Lee, Cheuk-kwong; Chan, Monica; Seto, Wai-kay; Wong, Danny Ka-ho; Lai, Ching-lung; Yuen, Man-fung

    2013-01-01

    Background For patients with chronic liver disease, different optimal liver stiffness cut-off values correspond to different stages of fibrosis, which are specific for the underlying liver disease and population. Aims To establish the normal ranges of liver stiffness in the healthy Chinese population without underlying liver disease. Methods This is a prospective cross sectional study of 2,528 healthy volunteers recruited from the general population and the Red Cross Transfusion Center in Hong Kong. All participants underwent a comprehensive questionnaire survey, measurement of weight, height, and blood pressure. Fasting liver function tests, glucose and cholesterol was performed. Abdominal ultrasound and transient elastography were performed on all participants. Results Of the 2,528 subjects, 1,998 were excluded with either abnormal liver parenchyma on ultrasound, chronic medical condition, abnormal blood tests including liver enzymes, fasting glucose, fasting cholesterol, high body mass index, high blood pressure, or invalid liver stiffness scan. The reference range for the 530 subjects without known liver disease was 2.3 to 5.9 kPa (mean 4.1, SD 0.89). The median liver stiffness was higher in males compared with females (4.3 vs 4.0 kPa respectively, p<0.001). There was also a decline in median Lliver stiffness in the older age group, from 4.2 kPa in those <25 years to 3.4 kPa for those >55 years (p=0.001). Conclusions The healthy reference range for liver stiffness in the Chinese population is 2.3 to 5.9 kPa. Female gender and older age group was associated with a lower median liver stiffness. PMID:24386446

  5. Stiffness and mass matrices for shells of revolution (SAMMSOR II)

    NASA Technical Reports Server (NTRS)

    Tillerson, J. R.; Haisler, W. E.

    1974-01-01

    Utilizing element properties, structural stiffness and mass matrices are generated for as many as twenty harmonics and stored on magnetic tape. Matrices generated constitute input data to be used by other stiffness of revolution programs. Variety of boundary and loading conditions can be employed without having to create new mass and stiffness matrices for each case.

  6. Damage Detection on Sudden Stiffness Reduction Based on Discrete Wavelet Transform

    PubMed Central

    Chen, Bo; Chen, Zhi-wei; Wang, Gan-jun; Xie, Wei-ping

    2014-01-01

    The sudden stiffness reduction in a structure may cause the signal discontinuity in the acceleration responses close to the damage location at the damage time instant. To this end, the damage detection on sudden stiffness reduction of building structures has been actively investigated in this study. The signal discontinuity of the structural acceleration responses of an example building is extracted based on the discrete wavelet transform. It is proved that the variation of the first level detail coefficients of the wavelet transform at damage instant is linearly proportional to the magnitude of the stiffness reduction. A new damage index is proposed and implemented to detect the damage time instant, location, and severity of a structure due to a sudden change of structural stiffness. Numerical simulation using a five-story shear building under different types of excitation is carried out to assess the effectiveness and reliability of the proposed damage index for the building at different damage levels. The sensitivity of the damage index to the intensity and frequency range of measurement noise is also investigated. The made observations demonstrate that the proposed damage index can accurately identify the sudden damage events if the noise intensity is limited. PMID:24991647

  7. Damage detection on sudden stiffness reduction based on discrete wavelet transform.

    PubMed

    Chen, Bo; Chen, Zhi-wei; Wang, Gan-jun; Xie, Wei-ping

    2014-01-01

    The sudden stiffness reduction in a structure may cause the signal discontinuity in the acceleration responses close to the damage location at the damage time instant. To this end, the damage detection on sudden stiffness reduction of building structures has been actively investigated in this study. The signal discontinuity of the structural acceleration responses of an example building is extracted based on the discrete wavelet transform. It is proved that the variation of the first level detail coefficients of the wavelet transform at damage instant is linearly proportional to the magnitude of the stiffness reduction. A new damage index is proposed and implemented to detect the damage time instant, location, and severity of a structure due to a sudden change of structural stiffness. Numerical simulation using a five-story shear building under different types of excitation is carried out to assess the effectiveness and reliability of the proposed damage index for the building at different damage levels. The sensitivity of the damage index to the intensity and frequency range of measurement noise is also investigated. The made observations demonstrate that the proposed damage index can accurately identify the sudden damage events if the noise intensity is limited.

  8. Damage detection on sudden stiffness reduction based on discrete wavelet transform.

    PubMed

    Chen, Bo; Chen, Zhi-wei; Wang, Gan-jun; Xie, Wei-ping

    2014-01-01

    The sudden stiffness reduction in a structure may cause the signal discontinuity in the acceleration responses close to the damage location at the damage time instant. To this end, the damage detection on sudden stiffness reduction of building structures has been actively investigated in this study. The signal discontinuity of the structural acceleration responses of an example building is extracted based on the discrete wavelet transform. It is proved that the variation of the first level detail coefficients of the wavelet transform at damage instant is linearly proportional to the magnitude of the stiffness reduction. A new damage index is proposed and implemented to detect the damage time instant, location, and severity of a structure due to a sudden change of structural stiffness. Numerical simulation using a five-story shear building under different types of excitation is carried out to assess the effectiveness and reliability of the proposed damage index for the building at different damage levels. The sensitivity of the damage index to the intensity and frequency range of measurement noise is also investigated. The made observations demonstrate that the proposed damage index can accurately identify the sudden damage events if the noise intensity is limited. PMID:24991647

  9. Constrained hierarchical least square nonlinear equation solvers. [for indefinite stiffness and large structural deformations

    NASA Technical Reports Server (NTRS)

    Padovan, J.; Lackney, J.

    1986-01-01

    The current paper develops a constrained hierarchical least square nonlinear equation solver. The procedure can handle the response behavior of systems which possess indefinite tangent stiffness characteristics. Due to the generality of the scheme, this can be achieved at various hierarchical application levels. For instance, in the case of finite element simulations, various combinations of either degree of freedom, nodal, elemental, substructural, and global level iterations are possible. Overall, this enables a solution methodology which is highly stable and storage efficient. To demonstrate the capability of the constrained hierarchical least square methodology, benchmarking examples are presented which treat structure exhibiting highly nonlinear pre- and postbuckling behavior wherein several indefinite stiffness transitions occur.

  10. Cholesterol depletion increases membrane stiffness of aortic endothelial cells.

    PubMed

    Byfield, Fitzroy J; Aranda-Espinoza, Helim; Romanenko, Victor G; Rothblat, George H; Levitan, Irena

    2004-11-01

    This study has investigated the effect of cellular cholesterol on membrane deformability of bovine aortic endothelial cells. Cellular cholesterol content was depleted by exposing the cells to methyl-beta-cyclodextrin or enriched by exposing the cells to methyl-beta-cyclodextrin saturated with cholesterol. Control cells were treated with methyl-beta-cyclodextrin-cholesterol at a molar ratio that had no effect on the level of cellular cholesterol. Mechanical properties of the cells with different cholesterol contents were compared by measuring the degree of membrane deformation in response to a step in negative pressure applied to the membrane by a micropipette. The experiments were performed on substrate-attached cells that maintained normal morphology. The data were analyzed using a standard linear elastic half-space model to calculate Young elastic modulus. Our observations show that, in contrast to the known effect of cholesterol on membrane stiffness of lipid bilayers, cholesterol depletion of bovine aortic endothelial cells resulted in a significant decrease in membrane deformability and a corresponding increase in the value of the elastic coefficient of the membrane, indicating that cholesterol-depleted cells are stiffer than control cells. Repleting the cells with cholesterol reversed the effect. An increase in cellular cholesterol to a level higher than that of normal cells, however, had no effect on the elastic properties of bovine aortic endothelial cells. We also show that although cholesterol depletion had no apparent effect on the intensity of F-actin-specific fluorescence, disrupting F-actin with latrunculin A abrogated the stiffening effect. We suggest that cholesterol depletion increases the stiffness of the membrane by altering the properties of the submembrane F-actin and/or its attachment to the membrane.

  11. Strong and stiff aramid nanofiber/carbon nanotube nanocomposites.

    PubMed

    Zhu, Jiaqi; Cao, Wenxin; Yue, Mingli; Hou, Ying; Han, Jiecai; Yang, Ming

    2015-03-24

    Small but strong carbon nanotubes (CNTs) are fillers of choice for composite reinforcement owing to their extraordinary modulus and strength. However, the mechanical properties of the nanocomposites are still much below those for mechanical parameters of individual nanotubes. The gap between the expectation and experimental results arises not only from imperfect dispersion and poor load transfer but also from the unavailability of strong polymers that can be effectively utilized within the composites of nanotubes. Aramid nanofibers (ANFs) with analogous morphological features to nanotubes represent a potential choice to complement nanotubes given their intrinsic high mechanical performance and the dispersible nature, which enables solvent-based processing methods. In this work, we showed that composite films made from ANFs and multiwalled CNTs (MWCNTs) by vacuum-assisted flocculation and vacuum-assisted layer-by-layer assembly exhibited high ultimate strength of up to 383 MPa and Young's modulus (stiffness) of up to 35 GPa, which represent the highest values among all the reported random CNT nanocomposites. Detailed studies using different imaging and spectroscopic characterizations suggested that the multiple interfacial interactions between nanotubes and ANFs including hydrogen bonding and π-π stacking are likely the key parameters responsible for the observed mechanical improvement. Importantly, our studies further revealed the attractive thermomechanical characteristics of these nanocomposites with high thermal stability (up to 520 °C) and ultralow coefficients of thermal expansion (2-6 ppm·K(-1)). Our results indicated that ANFs are promising nanoscale building blocks for functional ultrastrong and stiff materials potentially extendable to nanocomposites based on other nanoscale fillers. PMID:25712334

  12. The SSME HPFTP interstage seals: Analysis and experiments for leakage and reaction-force coefficients

    NASA Technical Reports Server (NTRS)

    Childs, D. W.

    1983-01-01

    An improved theory for the prediction of the rotordynamic coefficients of turbulent annular seals was developed. Predictions from the theory are compared to the experimental results and an approach for the direct calculation of empirical turbulent coefficients from test data are introduced. An improved short seal solution is shown to do a better job of calculating effective stiffness and damping coefficients than either the original short seal solution or a finite length solution. However, the original short seal solution does a much better job of predicting equivalent added mass coefficient.

  13. Effect of chain stiffness on polymer properties

    NASA Astrophysics Data System (ADS)

    Luettmer-Strathmann, Jutta

    2008-03-01

    Static and dynamic properties of polymers are affected by the stiffness of the chains. In this work, we investigate structural and thermodynamic properties of a lattice model for semiflexible polymer chains. The model is an extension of Shaffer's bond- fluctuation model and includes attractive interactions between monomers and an adjustable bending penalty that determines the Kuhn segment length. For isolated chains, a competition between monomer-monomer interactions and bending penalties determines the chain conformations at low temperatures. For dense melts, packing effects play an important role in the structure and thermodynamics of the polymeric liquid. In order to investigate static properties as a function of temperature and chain stiffness, we perform Wang-Landau type simulations and construct densities of states over the two-dimensional state space of monomer-monomer and bending contributions to the internal energy.

  14. Light weight high-stiffness stage platen

    DOEpatents

    Spence, Paul A.

    2001-01-01

    An improved light weight, stiff stage platen for photolithography is provided. The high stiffness of the stage platen is exemplified by a relatively high first resonant vibrational mode as determined, for instance, by finite element modal analysis. The stage platen can be employed to support a chuck that is designed to secure a mask or wafer. The stage platen includes a frame that has interior walls that define an interior region and that has exterior walls wherein the outer surfaces of at least two adjacent walls are reflective mirror surfaces; and a matrix of ribs within the interior region that is connected to the interior walls wherein the stage platen exhibits a first vibrational mode at a frequency of greater than about 1000 Hz.

  15. Electron profile stiffness and critical gradient studies

    NASA Astrophysics Data System (ADS)

    DeBoo, J. C.; Petty, C. C.; White, A. E.; Burrell, K. H.; Doyle, E. J.; Hillesheim, J. C.; Holland, C.; McKee, G. R.; Rhodes, T. L.; Schmitz, L.; Smith, S. P.; Wang, G.; Zeng, L.

    2012-08-01

    Electron profile stiffness was studied in DIII-D L-mode discharges by systematically varying the heat flux in a narrow region with electron cyclotron heating and measuring the local change produced in ∇Te. Electron stiffness was found to slowly increase with toroidal rotation velocity. A critical inverse temperature gradient scale length 1/LC ˜ 3 m-1 was identified at ρ =0.6 and found to be independent of rotation. Both the heat pulse diffusivity and the power balance diffusivity, the latter determined by integrating the measured dependence of the heat pulse diffusivity on -∇Te, were fit reasonably well by a model containing a critical inverse temperature gradient scale length and varying linearly with 1/LT above the threshold.

  16. Gyrokinetic Transport Stiffness Calculations on Stellarator Geometries

    NASA Astrophysics Data System (ADS)

    Faber, B. J.; Mynick, H.; Weir, G. M.; Likin, K. M.; Talmadge, J. N.

    2012-10-01

    A significant, unanswered question in plasma physics is the difference in transport ``stiffness'' between tokamaks and stellarators. In an effort to shed light on this issue, presented are nonlinear gyrokinetic calculations on various machine geometries: the Helically Symmetric Experiment, the National Compact Stellarator Experiment and an equivalent tokamak configuration. Nonlinear gyrokinetic fluxes have been compared directly to experimental fluxes observed in HSX power modulation experiments. Linear calculations on HSX reveal large growth rates due to both ion temperature gradient and trapped electron turbulence, necessitating a kinetic treatment of electrons; one of the first calculations of its kind for stellarators. A comparison of transport stiffness profiles computed through nonlinear gyrokinetic calculations of ion temperature gradient turbulence for the different machine configurations will be presented.

  17. Electron profile stiffness and critical gradient studies

    SciTech Connect

    DeBoo, J. C.; Petty, C. C.; Burrell, K. H.; Smith, S. P.; White, A. E.; Doyle, E. J.; Hillesheim, J. C.; Rhodes, T. L.; Schmitz, L.; Wang, G.; Zeng, L.; Holland, C.; McKee, G. R.

    2012-08-15

    Electron profile stiffness was studied in DIII-D L-mode discharges by systematically varying the heat flux in a narrow region with electron cyclotron heating and measuring the local change produced in {nabla}T{sub e}. Electron stiffness was found to slowly increase with toroidal rotation velocity. A critical inverse temperature gradient scale length 1/L{sub C} {approx} 3 m{sup -1} was identified at {rho}=0.6 and found to be independent of rotation. Both the heat pulse diffusivity and the power balance diffusivity, the latter determined by integrating the measured dependence of the heat pulse diffusivity on -{nabla}T{sub e}, were fit reasonably well by a model containing a critical inverse temperature gradient scale length and varying linearly with 1/L{sub T} above the threshold.

  18. Stiff modes in spinvalve simulations with OOMMF

    NASA Astrophysics Data System (ADS)

    Mitropoulos, Spyridon; Tsiantos, Vassilis; Ovaliadis, Kyriakos; Kechrakos, Dimitris; Donahue, Michael

    2016-04-01

    Micromagnetic simulations are an important tool for the investigation of magnetic materials. Micromagnetic software uses various techniques to solve differential equations, partial or ordinary, involved in the dynamic simulations. Euler, Runge-Kutta, Adams, and BDF (Backward Differentiation Formulae) are some of the methods used for this purpose. In this paper, spinvalve simulations are investigated. Evidence is presented showing that these systems have stiff modes, and that implicit methods such as BDF are more effective than explicit methods in such cases.

  19. METHOD OF HYPERBOLIC SYSTEMS WITH STIFF RELAXATION

    SciTech Connect

    R. B. LOWRIE; J. E. MOREL

    2001-03-01

    Three methods are analyzed for solving a linear hyperbolic system that contains stiff relaxation. We show that the semi-discrete discontinuous Galerkin method, with a linear basis, is accurate when the relaxation time is unresolved (asymptotically preserving--AP). A recently developed central method is shown to be non-AP. To discriminate between AP and non-AP methods, we argue that one must study problems that are diffusion dominated.

  20. Stiff-Person Syndrome: Case Series

    PubMed Central

    Jung, Yu Jin; Jeong, Han G.; Kim, Ryul; Kim, Han-Joon; Jeon, Beom S.

    2014-01-01

    Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other autoimmune disease. Here we report three cases of patients with classical SPS finally confirmed by high serum level of GAD antibodies. All of our patients respond favorably to gamma amino butyric acid-enhancing drugs and immunotherapies. PMID:24926406

  1. The stiffness tailoring of megawatt wind turbine

    NASA Astrophysics Data System (ADS)

    Li, Z. M.; Li, C.; Ye, Z.; Wu, P.; Lu, Y. F.

    2013-12-01

    Wind power has developed rapidly in recently years, the wind turbine's blades determine the performance of the device and the power. In this paper, we used integrated tailoring aimed at institutional characteristics of horizontal axis wind turbine with the composite laminated plate theory, then analyzed the composite blades of wind turbine by combining experimental analysis and finite elements method, and finally studied the influences that composite material properties on stiffness tailoring with changes in the number of different layers.

  2. Contact stiffness and damping of liquid films in dynamic atomic force microscope

    NASA Astrophysics Data System (ADS)

    Xu, Rong-Guang; Leng, Yongsheng

    2016-04-01

    The mechanical properties and dissipation behaviors of nanometers confined liquid films have been long-standing interests in surface force measurements. The correlation between the contact stiffness and damping of the nanoconfined film is still not well understood. We establish a novel computational framework through molecular dynamics (MD) simulation for the first time to study small-amplitude dynamic atomic force microscopy (dynamic AFM) in a simple nonpolar liquid. Through introducing a tip driven dynamics to mimic the mechanical oscillations of the dynamic AFM tip-cantilever assembly, we find that the contact stiffness and damping of the confined film exhibit distinct oscillations within 6-7 monolayer distances, and they are generally out-of-phase. For the solid-like film with integer monolayer thickness, further compression of the film before layering transition leads to higher stiffness and lower damping, while much lower stiffness and higher damping occur at non-integer monolayer distances. These two alternating mechanisms dominate the mechanical properties and dissipation behaviors of simple liquid films under cyclic elastic compression and inelastic squeeze-out. Our MD simulations provide a direct picture of correlations between the structural property, mechanical stiffness, and dissipation behavior of the nanoconfined film.

  3. Contact stiffness and damping of liquid films in dynamic atomic force microscope.

    PubMed

    Xu, Rong-Guang; Leng, Yongsheng

    2016-04-21

    The mechanical properties and dissipation behaviors of nanometers confined liquid films have been long-standing interests in surface force measurements. The correlation between the contact stiffness and damping of the nanoconfined film is still not well understood. We establish a novel computational framework through molecular dynamics (MD) simulation for the first time to study small-amplitude dynamic atomic force microscopy (dynamic AFM) in a simple nonpolar liquid. Through introducing a tip driven dynamics to mimic the mechanical oscillations of the dynamic AFM tip-cantilever assembly, we find that the contact stiffness and damping of the confined film exhibit distinct oscillations within 6-7 monolayer distances, and they are generally out-of-phase. For the solid-like film with integer monolayer thickness, further compression of the film before layering transition leads to higher stiffness and lower damping, while much lower stiffness and higher damping occur at non-integer monolayer distances. These two alternating mechanisms dominate the mechanical properties and dissipation behaviors of simple liquid films under cyclic elastic compression and inelastic squeeze-out. Our MD simulations provide a direct picture of correlations between the structural property, mechanical stiffness, and dissipation behavior of the nanoconfined film. PMID:27389229

  4. MIGRAINE, CAROTID STIFFNESS AND GENETIC POLYMORPHISM.

    PubMed

    Kes, Vanja Basić; Jurasić, Miljenka-Jelena; Zavoreo, Iris; Corić, Lejla; Rotim, Kresimir

    2015-12-01

    Recently migraine has been associated with increased arterial stiffness, procoagulant state, increased incidence of cerebral white matter lesions (WML) and stroke. Our aim was to compare the characteristics of migraineurs to headache free controls regarding their functional carotid ultrasound parameters. Sixty patients (45 women) with migraine (mean age 40.42 ± 10.61 years) were compared with 45 controls (30 women) with no prior history of repeating headache (mean age 38.94 ± 5.46 years) using E-tracking software on Alpha 10 ultrasound platform. Student's t-test was used on statistical analysis with alpha < 0.05. All tested carotid vascular parameters were worse in patients with migraine including increased intima-media thickness, greater carotid diameter and carotid diameter change, as well as several arterial stiffness indices. Additionally, patients with migraine had greater incidence of homozygous mutations for procoagulant genes (MTHFR (C677T), PAI-1 and ACE I/D) than expected. Computed tomography and magnetic resonance imaging of the brain showed WML in 11 patients, four of them migraine with aura patients. Since we established increased carotid stiffness and higher frequency of procoagulant gene mutations in migraineurs, we propose prospective ultrasound monitoring in such patients, especially those with detected WML, in order to timely commence more active and specific preventive stroke management strategies.

  5. The intraclass correlation coefficient: distribution-free definition and test.

    PubMed

    Commenges, D; Jacqmin, H

    1994-06-01

    A definition of the intraclass correlation coefficient is given on the basis of a general class of random effect model. The conventional intraclass correlation coefficient and the intracluster correlation coefficient for binary data are both particular cases of the generalized coefficient. We derive the score test for the hypothesis of null intraclass correlation in the exponential family. The statistic does not depend on the particular distribution in this family and is related to the pairwise correlation coefficient. The test can be adjusted for explanatory variables.

  6. Extreme damping in composite materials with negative-stiffness inclusions.

    PubMed

    Lakes, R S; Lee, T; Bersie, A; Wang, Y C

    2001-03-29

    When a force deforms an elastic object, practical experience suggests that the resulting displacement will be in the same direction as the force. This property is known as positive stiffness. Less familiar is the concept of negative stiffness, where the deforming force and the resulting displacement are in opposite directions. (Negative stiffness is distinct from negative Poisson's ratio, which refers to the occurrence of lateral expansion upon stretching an object.) Negative stiffness can occur, for example, when the deforming object has stored (or is supplied with) energy. This property is usually unstable, but it has been shown theoretically that inclusions of negative stiffness can be stabilized within a positive-stiffness matrix. Here we describe the experimental realization of this composite approach by embedding negative-stiffness inclusions of ferroelastic vanadium dioxide in a pure tin matrix. The resulting composites exhibit extreme mechanical damping and large anomalies in stiffness, as a consequence of the high local strains that result from the inclusions deforming more than the composite as a whole. Moreover, for certain temperature ranges, the negative-stiffness inclusions are more effective than diamond inclusions for increasing the overall composite stiffness. We expect that such composites could be useful as high damping materials, as stiff structural elements or for actuator-type applications. PMID:11279490

  7. Regional brain stiffness changes across the Alzheimer's disease spectrum☆

    PubMed Central

    Murphy, Matthew C.; Jones, David T.; Jack, Clifford R.; Glaser, Kevin J.; Senjem, Matthew L.; Manduca, Armando; Felmlee, Joel P.; Carter, Rickey E.; Ehman, Richard L.; Huston, John

    2015-01-01

    Magnetic resonance elastography (MRE) is an MRI-based technique to noninvasively measure tissue stiffness. Currently well established for clinical use in the liver, MRE is increasingly being investigated to measure brain stiffness as a novel biomarker of a variety of neurological diseases. The purpose of this work was to apply a recently developed MRE pipeline to measure regional brain stiffness changes in human subjects across the Alzheimer's disease (AD) spectrum, and to gain insights into the biological processes underlying those stiffness changes by correlating stiffness with existing biomarkers of AD. The results indicate that stiffness changes occur mostly in the frontal, parietal and temporal lobes, in accordance with the known topography of AD pathology. Furthermore, stiffness in those areas correlates with existing imaging biomarkers of AD including hippocampal volumes and amyloid PET. Additional analysis revealed preliminary but significant evidence that the relationship between brain stiffness and AD severity is nonlinear and non-monotonic. Given that similar relationships have been observed in functional MRI experiments, we used task-free fMRI data to test the hypothesis that brain stiffness was sensitive to structural changes associated with altered functional connectivity. The analysis revealed that brain stiffness is significantly and positively correlated with default mode network connectivity. Therefore, brain stiffness as measured by MRE has potential to provide new and essential insights into the temporal dynamics of AD, as well as the relationship between functional and structural plasticity as it relates to AD pathophysiology. PMID:26900568

  8. Regional brain stiffness changes across the Alzheimer's disease spectrum.

    PubMed

    Murphy, Matthew C; Jones, David T; Jack, Clifford R; Glaser, Kevin J; Senjem, Matthew L; Manduca, Armando; Felmlee, Joel P; Carter, Rickey E; Ehman, Richard L; Huston, John

    2016-01-01

    Magnetic resonance elastography (MRE) is an MRI-based technique to noninvasively measure tissue stiffness. Currently well established for clinical use in the liver, MRE is increasingly being investigated to measure brain stiffness as a novel biomarker of a variety of neurological diseases. The purpose of this work was to apply a recently developed MRE pipeline to measure regional brain stiffness changes in human subjects across the Alzheimer's disease (AD) spectrum, and to gain insights into the biological processes underlying those stiffness changes by correlating stiffness with existing biomarkers of AD. The results indicate that stiffness changes occur mostly in the frontal, parietal and temporal lobes, in accordance with the known topography of AD pathology. Furthermore, stiffness in those areas correlates with existing imaging biomarkers of AD including hippocampal volumes and amyloid PET. Additional analysis revealed preliminary but significant evidence that the relationship between brain stiffness and AD severity is nonlinear and non-monotonic. Given that similar relationships have been observed in functional MRI experiments, we used task-free fMRI data to test the hypothesis that brain stiffness was sensitive to structural changes associated with altered functional connectivity. The analysis revealed that brain stiffness is significantly and positively correlated with default mode network connectivity. Therefore, brain stiffness as measured by MRE has potential to provide new and essential insights into the temporal dynamics of AD, as well as the relationship between functional and structural plasticity as it relates to AD pathophysiology.

  9. Hypertension and arterial stiffness in heart transplantation patients

    PubMed Central

    de Souza-Neto, João David; de Oliveira, Ítalo Martins; Lima-Rocha, Hermano Alexandre; Oliveira-Lima, José Wellington; Bacal, Fernando

    2016-01-01

    OBJECTIVES: Post-transplantation hypertension is prevalent and is associated with increased cardiovascular morbidity and subsequent graft dysfunction. The present study aimed to identify the factors associated with arterial stiffness as measured by the ambulatory arterial stiffness index. METHODS: The current study used a prospective, observational, analytical design to evaluate a group of adult heart transplantation patients. Arterial stiffness was obtained by monitoring ambulatory blood pressure and using the ambulatory arterial stiffness index as the surrogate outcome. Multivariate logistic regression analyses were performed to control confounding. RESULTS: In a group of 85 adult heart transplantation patients, hypertension was independently associated with arterial stiffness (OR 4.98, CI 95% 1.06-23.4) as well as systolic and diastolic blood pressure averages and nighttime descent. CONCLUSIONS: Measurement of ambulatory arterial stiffness index is a new, non-invasive method that is easy to perform, may contribute to better defining arterial stiffness prognosis and is associated with hypertension.

  10. Hypertension and arterial stiffness in heart transplantation patients

    PubMed Central

    de Souza-Neto, João David; de Oliveira, Ítalo Martins; Lima-Rocha, Hermano Alexandre; Oliveira-Lima, José Wellington; Bacal, Fernando

    2016-01-01

    OBJECTIVES: Post-transplantation hypertension is prevalent and is associated with increased cardiovascular morbidity and subsequent graft dysfunction. The present study aimed to identify the factors associated with arterial stiffness as measured by the ambulatory arterial stiffness index. METHODS: The current study used a prospective, observational, analytical design to evaluate a group of adult heart transplantation patients. Arterial stiffness was obtained by monitoring ambulatory blood pressure and using the ambulatory arterial stiffness index as the surrogate outcome. Multivariate logistic regression analyses were performed to control confounding. RESULTS: In a group of 85 adult heart transplantation patients, hypertension was independently associated with arterial stiffness (OR 4.98, CI 95% 1.06-23.4) as well as systolic and diastolic blood pressure averages and nighttime descent. CONCLUSIONS: Measurement of ambulatory arterial stiffness index is a new, non-invasive method that is easy to perform, may contribute to better defining arterial stiffness prognosis and is associated with hypertension. PMID:27652829

  11. Dynamic behavior of stay cables with passive negative stiffness dampers

    NASA Astrophysics Data System (ADS)

    Shi, Xiang; Zhu, Songye; Li, Jin-Yang; Spencer, Billie F., Jr.

    2016-07-01

    This paper systematically investigates the dynamic behavior of stay cables with passive negative stiffness dampers (NSD) installed close to the cable end. A passive NSD is modeled as a combination of a negative stiffness spring and a viscous damper. Through both analytical and numerical approaches, parametric analysis of negative stiffness and viscous damping are conducted to systematically evaluate the vibration control performance of passive NSD on stay cables. Since negative stiffness is an unstable element, the boundary of passive negative stiffness for stay cables to maintain stability is also derived. Results reveal that the asymptotic approach is only applicable to passive dampers with positive or moderate negative stiffness, and loses its accuracy when a passive NSD possesses significant negative stiffness. It has been found that the performance of passive NSD can be much better than those of conventional viscous dampers. The superior control performance of passive NSD in cable vibration mitigation is validated through numerical simulations of a full-scale stay cable.

  12. Nanocharacterization of the negative stiffness of ferroelectric materials

    NASA Astrophysics Data System (ADS)

    Alipour Skandani, A.; Ctvrtlik, R.; Al-Haik, M.

    2014-08-01

    Phase changing materials such as ferroelectric materials could exhibit negative stiffness under certain thermomechanical environments. This negative stiffness is embodied by a deflection along the opposite direction of the applied load. So far negative stiffness materials were investigated with the specific morphology of embedded inclusions in stiff matrices then the resulting composite is studied to measure the behavior of each constituent indirectly. In this study, a modified nonisothermal nanoindentation method is developed to measure the negative stiffness of triglycine sulfate single crystal directly. This in-situ method is intended to first demonstrate the feasibility of detecting the negative stiffness via nanoindentation and nanocreep of a ferroelectric material at its Curie point and then to quantify the negative stiffness without the need for embedding the crystal within a stiffer matrix.

  13. Muscle short-range stiffness can be used to estimate the endpoint stiffness of the human arm

    PubMed Central

    Hu, Xiao; Murray, Wendy M.

    2011-01-01

    The mechanical properties of the human arm are regulated to maintain stability across many tasks. The static mechanics of the arm can be characterized by estimates of endpoint stiffness, considered especially relevant for the maintenance of posture. At a fixed posture, endpoint stiffness can be regulated by changes in muscle activation, but which activation-dependent muscle properties contribute to this global measure of limb mechanics remains unclear. We evaluated the role of muscle properties in the regulation of endpoint stiffness by incorporating scalable models of muscle stiffness into a three-dimensional musculoskeletal model of the human arm. Two classes of muscle models were tested: one characterizing short-range stiffness and two estimating stiffness from the slope of the force-length curve. All models were compared with previously collected experimental data describing how endpoint stiffness varies with changes in voluntary force. Importantly, muscle properties were not fit to the experimental data but scaled only by the geometry of individual muscles in the model. We found that force-dependent variations in endpoint stiffness were accurately described by the short-range stiffness of active arm muscles. Over the wide range of evaluated arm postures and voluntary forces, the musculoskeletal model incorporating short-range stiffness accounted for 98 ± 2, 91 ± 4, and 82 ± 12% of the variance in stiffness orientation, shape, and area, respectively, across all simulated subjects. In contrast, estimates based on muscle force-length curves were less accurate in all measures, especially stiffness area. These results suggest that muscle short-range stiffness is a major contributor to endpoint stiffness of the human arm. Furthermore, the developed model provides an important tool for assessing how the nervous system may regulate endpoint stiffness via changes in muscle activation. PMID:21289133

  14. Aortic stiffness and distensibility among hypertensives.

    PubMed

    Meenakshisundaram, R; Kamaraj, K; Murugan, S; Thirumalaikolundusubramanian, P

    2009-09-01

    Hypertension is one among many factors that contribute to aortic stiffness, which has repercussions mainly on the heart. To assess aortic stiffness among essential hypertensives of South India and its relationship with gender. An analytical study was designed to assess aortic stiffness among 60 nonobese, nonalcoholic, nonsmoking, and non-caffeine consuming essential hypertensives without any overt illness or infection, and compared with 30 healthy age- and sex-matched nonhypertensives. They were assessed clinically and also by laboratory means. Their left ventricular mass (LV) and left ventricular ejection fraction (LVEF) were measured using Transthoracic echocardiogram. Aortic systolic and diastolic diameters were measured by using M-mode echocardiography during consecutive beats and averaged for each case. Finally, aortic stiffness was calculated. The data were analyzed statistically. Hypertensives were divided into Group I, consisting of patients with hypertension at least for 5 years, who were not adherent to medication, and Group II, consisting of patients with hypertension of duration between 6 months and 1 year. There were 20 males and 10 females in each group. There was no significant difference between the hypertensive groups and a control, normotensive, group with regard to BMI or total cholesterol. The means of LV mass (in grams), systolic BP (in mmHg), diastolic BP (in mmHg), aortic systolic diameter (in mm), aortic diastolic diameter (in mm), aortic distensibility (in mm), and aortic stiffness found in Group I, Group II, and controls were 105.8 +/- 23.8, 101.5 +/- 21, and 84 +/- 9.8; 138 +/- 14.2, 153 +/- 17.1, and 120 +/- 8.3; 90.5 +/- 11.6, 101.7 +/- 17.1, and 76.5 +/- 5; 30.85 +/- 2.6, 28.7 +/- 2.6, and 27.7 +/- 2.4; 28.7 +/- 2.2, 25.8 +/- 2.5, and 24.2 +/- 2.5; 2.14 +/- 0.3, 2.84 +/- 0.5, and 3.5 +/- 0.6; and 1.31 +/- 0.09, 1.14 +/- 0.1, and 1.04 +/- 0.08, respectively. The differences between the hypertensive groups and the control group were

  15. Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension

    PubMed Central

    Rain, Silvia; Andersen, Stine; Najafi, Aref; Gammelgaard Schultz, Jacob; da Silva Gonçalves Bós, Denielli; Handoko, M. Louis; Bogaard, Harm-Jan; Vonk-Noordegraaf, Anton; Andersen, Asger; van der Velden, Jolanda; Ottenheijm, Coen A.C.

    2016-01-01

    Background— The purpose of this study was to determine the relative contribution of fibrosis-mediated and myofibril-mediated stiffness in rats with mild and severe right ventricular (RV) dysfunction. Methods and Results— By performing pulmonary artery banding of different diameters for 7 weeks, mild RV dysfunction (Ø=0.6 mm) and severe RV dysfunction (Ø=0.5 mm) were induced in rats. The relative contribution of fibrosis- and myofibril-mediated RV stiffness was determined in RV trabecular strips. Total myocardial stiffness was increased in trabeculae from both mild and severe RV dysfunction in comparison to controls. In severe RV dysfunction, increased RV myocardial stiffness was explained by both increased fibrosis-mediated stiffness and increased myofibril-mediated stiffness, whereas in mild RV dysfunction, only myofibril-mediated stiffness was increased in comparison to control. Histological analyses revealed that RV fibrosis gradually increased with severity of RV dysfunction, whereas the ratio of collagen I/III expression was only elevated in severe RV dysfunction. Stiffness measurements in single membrane-permeabilized RV cardiomyocytes demonstrated a gradual increase in RV myofibril stiffness, which was partially restored by protein kinase A in both mild and severe RV dysfunction. Increased expression of compliant titin isoforms was observed only in mild RV dysfunction, whereas titin phosphorylation was reduced in both mild and severe RV dysfunction. Conclusions— RV myocardial stiffness is increased in rats with mild and severe RV dysfunction. In mild RV dysfunction, stiffness is mainly determined by increased myofibril stiffness. In severe RV dysfunction, both myofibril- and fibrosis-mediated stiffness contribute to increased RV myocardial stiffness. PMID:27370069

  16. Knee stiffness following anterior cruciate ligament reconstruction: the incidence and associated factors of knee stiffness following anterior cruciate ligament reconstruction.

    PubMed

    Robertson, G A J; Coleman, S G S; Keating, J F

    2009-08-01

    We reviewed 100 patients retrospectively following primary ACL reconstruction with quadruple hamstring autografts to evaluate the incidence and factors associated with postoperative stiffness. Stiffness was defined as any loss of motion using the contra-lateral leg as a control. The median delay between injury and operation was 15 months. The incidence of stiffness was 12% at 6 months post-reconstruction. Both incomplete attendance at physiotherapy (p<0.005) and previous knee surgery (p<0.005) were the strongest predictors of the stiffness. Anterior knee pain was also associated with the stiffness (p<0.029). Factors that failed to show a significant association with the stiffness included associated MCL sprain at injury (p=0.32), post-injury stiffness (p=1.00) and concomitant menisectomy at reconstruction (p=0.54). Timing of surgery also did not appear to influence the onset of stiffness (median delays: 29 months for stiff patients; 14 months for non-stiff patients). The rate of stiffness fell to 5% at 12 months postreconstruction, without operative intervention.

  17. Anesthesia in a patient with Stiff Person Syndrome.

    PubMed

    Yagan, Ozgur; Özyilmaz, Kadir; Özmaden, Ahmet; Sayin, Özgür; Hanci, Volkan

    2016-01-01

    Stiff Person Syndrome (SPS), typified by rigidity in muscles of the torso and extremities and painful episodic spasms, is a rare autoimmune-based neurological disease. Here we present the successful endotracheal intubation and application of TIVA without muscle relaxants on an SPS patient. A 46 years old male patient was operated with ASA-II physical status because of lumber vertebral compression fracture. After induction of anesthesia using lidocaine, propofol and remifentanil tracheal intubation was completed easily without neuromuscular blockage. Anesthesia was maintained with propofol, remifentanil and O2/air mixture. After a problem-free intraoperative period the patient was extubated and seven days later was discharged walking with aid. Though the mechanism is not clear neuromuscular blockers and volatile anesthetics may cause prolonged hypotonia in patients with SPS. We think the TIVA technique, a general anesthetic practice which does not require neuromuscular blockage, is suitable for these patients.

  18. Anesthesia in a patient with Stiff Person Syndrome.

    PubMed

    Yagan, Ozgur; Özyilmaz, Kadir; Özmaden, Ahmet; Sayin, Özgür; Hanci, Volkan

    2016-01-01

    Stiff Person Syndrome (SPS), typified by rigidity in muscles of the torso and extremities and painful episodic spasms, is a rare autoimmune-based neurological disease. Here we present the successful endotracheal intubation and application of TIVA without muscle relaxants on an SPS patient. A 46 years old male patient was operated with ASA-II physical status because of lumber vertebral compression fracture. After induction of anesthesia using lidocaine, propofol and remifentanil tracheal intubation was completed easily without neuromuscular blockage. Anesthesia was maintained with propofol, remifentanil and O2/air mixture. After a problem-free intraoperative period the patient was extubated and seven days later was discharged walking with aid. Though the mechanism is not clear neuromuscular blockers and volatile anesthetics may cause prolonged hypotonia in patients with SPS. We think the TIVA technique, a general anesthetic practice which does not require neuromuscular blockage, is suitable for these patients. PMID:27591471

  19. Urinary Albumin Excretion is Increased in Patients with Rheumatoid Arthritis and Associated with Arterial Stiffness

    PubMed Central

    Becetti, Karima; Oeser, Annette; Ormseth, Michelle; Solus, Joseph F.; Raggi, Paolo; Stein, C. Michael; Chung, Cecilia P.

    2015-01-01

    Objective Rheumatoid arthritis (RA) is associated with increased risk of cardiovascular disease (CVD). High urinary albumin excretion is a risk factor for CVD in the general population, but its role in atherosclerosis in patients with RA is not well defined. Methods We determined the urine albumin to creatinine ratio (UACR) in 136 patients with RA and 79 controls. Individuals with diabetes or a clinical history of CVD were excluded. We measured coronary artery calcium (CAC) with electron beam computer tomography and augmentation index (AIX) using pulse wave analysis. In patients with RA, erythrocyte sedimentation rate (ESR) and concentrations of vascular cell adhesion protein-1 (VCAM-1), interleukin-10 (IL-10), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and cystatin-C were measured and results correlated with UACR. Results Patients with RA had higher UACR [median (IQR): 7.6 (4.0-15.5) mg/g than control subjects: 5.6 (3.3-9.0)mg/g, p=0.02]. The presence of CAC was not associated with UACR in RA or control subjects. In patients with RA, UACR was significantly correlated with AIX (rho=0.24, p=0.01), higher levels of VCAM-1 (rho=0.2, p=0.01) and lower levels of IL-10 (rho=-0.2, p=0.02). The association between AIX and higher UACR remained significant in multivariate analysis [β coefficient of 1.9 (95% CI 0.4-3.4), p=0.01 that adjusted for age, sex, and race]. Conclusion Urinary albumin excretion was higher in RA patients than controls and correlated with increased arterial stiffness, higher VCAM-1, and lower IL-10 concentrations. PMID:25641887

  20. Laser application on haptics: Tactile stiffness measurement

    NASA Astrophysics Data System (ADS)

    Scalise, L.; Memeo, M.; Cannella, F.; Valente, M.; Caldwell, D. G.; Tomasini, E. P.

    2012-06-01

    There is a great interest in exploring the proprieties of the sense of the touch, its detailed knowledge in fact is a key issue in the area of robotics, haptics and human-machine interaction. In this paper, the authors focus their attention on a novel measurement method for the assessment of the tactile stiffness based on a original test rig; tactile stiffness is defined as the ratio between force, exerted by the finger, and the displacement of the finger tip operated during the test. To reach this scope, the paper describes a specific experimental test-rig used for the evaluation of subject tactile sensitivity, where finger force applied during tests as well as displacement and velocity of displacement, operated by the subject under investigation, are measured. Results show that tactile stiffness is linear respect to stimuli spatial difference (which is proportional to the difficulty to detect the variation of them). In particular, it has been possible to relate the force and displacement measured during the tests. The relationship between the response of the subject to the grating, velocity and force is determined. These results permit to carry out the further experimental tests on the same subject avoiding the use of a load cell and therefore simplifying the measurement test rig and data post-processing. Indeed, the first aspect (use of a load cell) can be relevant, because the grating positions are different, requiring a specific re-calibration and setting before each trial; while the second aspect allows simplify the test rig complexity and the processing algorithm.

  1. Vibration Control via Stiffness Switching of Magnetostrictive Transducers

    NASA Technical Reports Server (NTRS)

    Scheidler, Justin J.; Asnani, Vivake M.; Dapino, Marcelo J.

    2016-01-01

    This paper presents a computational study of structural vibration control that is realized by switching a magnetostrictive transducer between high and low stiffness states. Switching is accomplished by either changing the applied magnetic field with a voltage excitation or changing the shunt impedance on the transducer's coil (i.e., the magnetostrictive material's magnetic boundary condition). Switched-stiffness vibration control is simulated using a lumped mass supported by a damper and the magnetostrictive transducer (mount), which is represented by a nonlinear, electromechanical model. Free vibration of the mass is calculated while varying the mount's stiffness according to a reference switched-stiffness vibration control law. The results reveal that switching the magnetic field produces the desired change in stiffness, but also an undesired actuation force that can significantly degrade the vibration control. Hence, a modified switched-stiffness control law that accounts for the actuation force is proposed and implemented for voltage-controlled stiffness switching. The influence of the magnetomechanical bias condition is also discussed. Voltage-controlled stiffness switching is found to introduce damping equivalent to a viscous damping factor up to about 0.25; this is shown to primarily result from active vibration reduction caused by the actuation force. The merit of magnetostrictive switched-stiffness vibration control is then quantified by comparing the results of voltage- and shunt-controlled stiffness switching to the performance of optimal magnetostrictive shunt damping.

  2. Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber.

    PubMed

    Artmann, G M

    1995-01-01

    .95 mPas/K, reflecting an inverse relationship between RBC viscosity and temperature. Using the automated version of this technique (Elias-c-) to test RBCs of 36 healthy subjects, we found the inter-individual coefficients of variation to be 8.6% for stiffness, 7.9% for relaxation time and 12.4% for stiffness-relaxation time product.

  3. POST-TRAUMATIC STIFFNESS OF THE ELBOW

    PubMed Central

    Filh, Geraldo Motta; Galvão, Marcus Vinicius

    2015-01-01

    Elbow stiffness is a common problem after joint trauma, causing functional impairment of the upper limb. The severity of the dysfunction depends on the nature of the initial trauma and the treatment used. Appropriate clinical evaluation and complementary examinations are essential for therapeutic planning. Several surgical techniques are now available and the recommendation must be made in accordance with patient characteristics, degree of joint limitation and the surgeon's skill. Joint incongruence and degeneration have negative effects on the prognosis, but heterotrophic ossification alone has been correlated with a favorable surgical prognosis. PMID:27022563

  4. On waveguide modeling of stiff piano strings

    NASA Astrophysics Data System (ADS)

    Ducasse, Éric

    2005-09-01

    Bensa et al. [J. Acoust. Soc. Am. 114, 1095-1107 (2003), Sec. IV] recently proposed a waveguide model for the transverse displacement of a stiff piano string. The study described here is an attempt to cast a complementary light on this topic, based on a common wave approach instead of a modal approach. A pair of weakly attenuated traveling waves and a pair of fast-decaying waves both satisfy the one-dimensional wave equation developed by Bensa et al. These solutions have to be carefully considered, however, for portions of string interacting with the hammer felt, the bridge, or the capo d'astro bar.

  5. An experimental and theoretical comparison of rotordynamic coefficients for sawtooth-pattern damper seals. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Nolan, Steven Anthony

    1987-01-01

    A brief review of the annular seal theory as related to rotordynamics for liquid seals is presented. Also included is an overview of Childs and Kim's current theory for calculating empirical turbulence coefficients and predicting stiffness and damping coefficients for surface roughened damper seals. The designation sawtooth-pattern refers to a seal stator with a roughness pattern whose cross section normal to the seal axis resembles a sawtooth with the teeth directed against the flow. The net stiffness and damping coefficients for the eleven seals are compared to each other, a smooth seal, and the optimum-configuration damper seal previously tested. The experimental force coefficients, the net damping, and the net stiffness coefficients for four of the sawtooth seals are compared to the predictions of Childs and Kim's analysis. The sawtooth-pattern seal had less net damping than the hole-pattern seal but more than the smooth seal. The stiffness was comparable to the hole-pattern. Both the sawtooth and hole-pattern seals leaked less than the smooth seal, while the sawtooth-pattern seal with maximum damping leaked more than the hole-pattern seal. The theoretical predictions compared relatively poorly to the experimental results obtained for the rotordynamic coefficients of the seals investigation.

  6. Normal response function method for mass and stiffness matrix updating using complex FRFs

    NASA Astrophysics Data System (ADS)

    Pradhan, S.; Modak, S. V.

    2012-10-01

    Quite often a structural dynamic finite element model is required to be updated so as to accurately predict the dynamic characteristics like natural frequencies and the mode shapes. Since in many situations undamped natural frequencies and mode shapes need to be predicted, it has generally been the practice in these situations to seek updating of only mass and stiffness matrix so as to obtain a reliable prediction model. Updating using frequency response functions (FRFs) has been one of the widely used approaches for updating, including updating of mass and stiffness matrices. However, the problem with FRF based methods, for updating mass and stiffness matrices, is that these methods are based on use of complex FRFs. Use of complex FRFs to update mass and stiffness matrices is not theoretically correct as complex FRFs are not only affected by these two matrices but also by the damping matrix. Therefore, in situations where updating of only mass and stiffness matrices using FRFs is required, the use of complex FRFs based updating formulation is not fully justified and would lead to inaccurate updated models. This paper addresses this difficulty and proposes an improved FRF based finite element model updating procedure using the concept of normal FRFs. The proposed method is a modified version of the existing response function method that is based on the complex FRFs. The effectiveness of the proposed method is validated through a numerical study of a simple but representative beam structure. The effect of coordinate incompleteness and robustness of method under presence of noise is investigated. The results of updating obtained by the improved method are compared with the existing response function method. The performance of the two approaches is compared for cases of light, medium and heavily damped structures. It is found that the proposed improved method is effective in updating of mass and stiffness matrices in all the cases of complete and incomplete data and

  7. Effects of non-uniform stiffness on the swimming performance of a passively-flexing, fish-like foil model.

    PubMed

    Lucas, Kelsey N; Thornycroft, Patrick J M; Gemmell, Brad J; Colin, Sean P; Costello, John H; Lauder, George V

    2015-10-01

    Simple mechanical models emulating fish have been used recently to enable targeted study of individual factors contributing to swimming locomotion without the confounding complexity of the whole fish body. Yet, unlike these uniform models, the fish body is notable for its non-uniform material properties. In particular, flexural stiffness decreases along the fish's anterior-posterior axis. To identify the role of non-uniform bending stiffness during fish-like propulsion, we studied four foil model configurations made by adhering layers of plastic sheets to produce discrete regions of high (5.5 × 10(-5) Nm(2)) and low (1.9 × 10(-5) Nm(2)) flexural stiffness of biologically-relevant magnitudes. This resulted in two uniform control foils and two foils with anterior regions of high stiffness and posterior regions of low stiffness. With a mechanical flapping foil controller, we measured forces and torques in three directions and quantified swimming performance under both heaving (no pitch) and constant 0° angle of attack programs. Foils self-propelled at Reynolds number 21 000-115 000 and Strouhal number ∼0.20-0.25, values characteristic of fish locomotion. Although previous models have emphasized uniform distributions and heaving motions, the combination of non-uniform stiffness distributions and 0° angle of attack pitching program was better able to reproduce the kinematics of freely-swimming fish. This combination was likewise crucial in maximizing swimming performance and resulted in high self-propelled speeds at low costs of transport and large thrust coefficients at relatively high efficiency. Because these metrics were not all maximized together, selection of the 'best' stiffness distribution will depend on actuation constraints and performance goals. These improved models enable more detailed, accurate analyses of fish-like swimming. PMID:26447541

  8. The acute effect of maximal exercise on central and peripheral arterial stiffness indices and hemodynamics in children and adults.

    PubMed

    Melo, Xavier; Fernhall, Bo; Santos, Diana A; Pinto, Rita; Pimenta, Nuno M; Sardinha, Luís B; Santa-Clara, Helena

    2016-03-01

    This study compared the effects of a bout of maximal running exercise on arterial stiffness in children and adults. Right carotid blood pressure and artery stiffness indices measured by pulse wave velocity (PWV), compliance and distensibility coefficients, stiffness index α and β (echo-tracking), contralateral carotid blood pressure, and upper and lower limb and central/aortic PWV (applanation tonometry) were taken at rest and 10 min after a bout of maximal treadmill running in 34 children (7.38 ± 0.38 years) and 45 young adults (25.22 ± 0.91 years) having similar aerobic potential. Two-by-two repeated measures analysis of variance and analysis of covariance were used to detect differences with exercise between groups. Carotid pulse pressure (PP; η(2) = 0.394) increased more in adults after exercise (p < 0.05). Compliance (η(2) = 0.385) decreased in particular in adults and in those with high changes in distending pressure, similarly to stiffness index α and β. Carotid PWV increased more in adults and was related to local changes in PP but not mean arterial pressure (MAP). Stiffness in the lower limbs decreased (η(2) = 0.115) but apparently only in those with small MAP changes (η(2) = 0.111). No significant exercise or group interaction effects were found when variables were adjusted to height. An acute bout of maximal exercise can alter arterial stiffness and hemodynamics in the carotid artery and within the active muscle beds. Arterial stiffness and hemodynamic response to metabolic demands during exercise in children simply reflect their smaller body size and may not indicate a particular physiological difference compared with adults. PMID:26842667

  9. Simple polyacrylamide-based multiwell stiffness assay for the study of stiffness-dependent cell responses.

    PubMed

    Syed, Sana; Karadaghy, Amin; Zustiak, Silviya

    2015-03-25

    Currently, most of the in vitro cell research is performed on rigid tissue culture polystyrene (~1 GPa), while most cells in the body are attached to a matrix that is elastic and much softer (0.1-100 kPa). Since such stiffness mismatch greatly affects cell responses, there is a strong interest in developing hydrogel materials that span a wide range of stiffness to serve as cell substrates. Polyacrylamide gels, which are inexpensive and cover the stiffness range of all soft tissues in the body, are the hydrogel of choice for many research groups. However, polyacrylamide gel preparation is lengthy, tedious, and only suitable for small batches. Here, we describe an assay which by utilizing a permanent flexible plastic film as a structural support for the gels, enables the preparation of polyacrylamide gels in a multiwell plate format. The technique is faster, more efficient, and less costly than current methods and permits the preparation of gels of custom sizes not otherwise available. As it doesn't require any specialized equipment, the method could be easily adopted by any research laboratory and would be particularly useful in research focused on understanding stiffness-dependent cell responses.

  10. Simple polyacrylamide-based multiwell stiffness assay for the study of stiffness-dependent cell responses.

    PubMed

    Syed, Sana; Karadaghy, Amin; Zustiak, Silviya

    2015-01-01

    Currently, most of the in vitro cell research is performed on rigid tissue culture polystyrene (~1 GPa), while most cells in the body are attached to a matrix that is elastic and much softer (0.1-100 kPa). Since such stiffness mismatch greatly affects cell responses, there is a strong interest in developing hydrogel materials that span a wide range of stiffness to serve as cell substrates. Polyacrylamide gels, which are inexpensive and cover the stiffness range of all soft tissues in the body, are the hydrogel of choice for many research groups. However, polyacrylamide gel preparation is lengthy, tedious, and only suitable for small batches. Here, we describe an assay which by utilizing a permanent flexible plastic film as a structural support for the gels, enables the preparation of polyacrylamide gels in a multiwell plate format. The technique is faster, more efficient, and less costly than current methods and permits the preparation of gels of custom sizes not otherwise available. As it doesn't require any specialized equipment, the method could be easily adopted by any research laboratory and would be particularly useful in research focused on understanding stiffness-dependent cell responses. PMID:25866916

  11. Substrate stiffness regulates solubility of cellular vimentin

    PubMed Central

    Murray, Maria E.; Mendez, Melissa G.; Janmey, Paul A.

    2014-01-01

    The intermediate filament protein vimentin is involved in the regulation of cell behavior, morphology, and mechanical properties. Previous studies using cells cultured on glass or plastic substrates showed that vimentin is largely insoluble. Although substrate stiffness was shown to alter many aspects of cell behavior, changes in vimentin organization were not reported. Our results show for the first time that mesenchymal stem cells (hMSCs), endothelial cells, and fibroblasts cultured on different-stiffness substrates exhibit biphasic changes in vimentin detergent solubility, which increases from nearly 0 to 67% in hMSCs coincident with increases in cell spreading and membrane ruffling. When imaged, the detergent-soluble vimentin appears to consist of small fragments the length of one or several unit-length filaments. Vimentin detergent solubility decreases when these cells are subjected to serum starvation, allowed to form cell–cell contacts, after microtubule disruption, or inhibition of Rac1, Rho-activated kinase, or p21-activated kinase. Inhibiting myosin or actin assembly increases vimentin solubility on rigid substrates. These data suggest that in the mechanical environment in vivo, vimentin is more dynamic than previously reported and its assembly state is sensitive to stimuli that alter cellular tension and morphology. PMID:24173714

  12. Multifunctional Stiff Carbon Foam Derived from Bread.

    PubMed

    Yuan, Ye; Ding, Yujie; Wang, Chunhui; Xu, Fan; Lin, Zaishan; Qin, Yuyang; Li, Ying; Yang, Minglong; He, Xiaodong; Peng, Qingyu; Li, Yibin

    2016-07-01

    The creation of stiff yet multifunctional three-dimensional porous carbon architecture at very low cost is still challenging. In this work, lightweight and stiff carbon foam (CF) with adjustable pore structure was prepared by using flour as the basic element via a simple fermentation and carbonization process. The compressive strength of CF exhibits a high value of 3.6 MPa whereas its density is 0.29 g/cm(3) (compressive modulus can be 121 MPa). The electromagnetic interference (EMI) shielding effectiveness measurements (specific EMI shielding effectiveness can be 78.18 dB·cm(3)·g(-1)) indicate that CF can be used as lightweight, effective shielding material. Unlike ordinary foam structure materials, the low thermal conductivity (lowest is 0.06 W/m·K) with high resistance to fire makes CF a good candidate for commercial thermal insulation material. These results demonstrate a promising method to fabricate an economical, robust carbon material for applications in industry as well as topics regarding environmental protection and improvement of energy efficiency. PMID:27295106

  13. Multifunctional Stiff Carbon Foam Derived from Bread.

    PubMed

    Yuan, Ye; Ding, Yujie; Wang, Chunhui; Xu, Fan; Lin, Zaishan; Qin, Yuyang; Li, Ying; Yang, Minglong; He, Xiaodong; Peng, Qingyu; Li, Yibin

    2016-07-01

    The creation of stiff yet multifunctional three-dimensional porous carbon architecture at very low cost is still challenging. In this work, lightweight and stiff carbon foam (CF) with adjustable pore structure was prepared by using flour as the basic element via a simple fermentation and carbonization process. The compressive strength of CF exhibits a high value of 3.6 MPa whereas its density is 0.29 g/cm(3) (compressive modulus can be 121 MPa). The electromagnetic interference (EMI) shielding effectiveness measurements (specific EMI shielding effectiveness can be 78.18 dB·cm(3)·g(-1)) indicate that CF can be used as lightweight, effective shielding material. Unlike ordinary foam structure materials, the low thermal conductivity (lowest is 0.06 W/m·K) with high resistance to fire makes CF a good candidate for commercial thermal insulation material. These results demonstrate a promising method to fabricate an economical, robust carbon material for applications in industry as well as topics regarding environmental protection and improvement of energy efficiency.

  14. Validity and Reliability of Two Field-Based Leg Stiffness Devices: Implications for Practical Use.

    PubMed

    Ruggiero, Luca; Dewhurst, Susan; Bampouras, Theodoros M

    2016-08-01

    Leg stiffness is an important performance determinant in several sporting activities. This study evaluated the criterion-related validity and reliability of 2 field-based leg stiffness devices, Optojump NextR (Optojump) and Myotest ProR (Myotest) in different testing approaches. Thirty-four males performed, on 2 separate sessions, 3 trials of 7 maximal hops, synchronously recorded from a force platform (FP), Optojump and Myotest. Validity (Pearson's correlation coefficient, r; relative mean bias; 95% limits of agreement, 95%LoA) and reliability (coefficient of variation, CV; intraclass correlation coefficient, ICC; standard error of measurement, SEM) were calculated for first attempt, maximal attempt, and average across 3 trials. For all 3 methods, Optojump correlated highly to the FP (range r = .98-.99) with small bias (range 0.91-0.92, 95%LoA 0.86-0.98). Myotest demonstrated high correlation to FP (range r = .81-.86) with larger bias (range 1.92-1.93, 95%LoA 1.63-2.23). Optojump yielded a low CV (range 5.9% to 6.8%), high ICC (range 0.82-0.86), and SEM ranging 1.8-2.1 kN/m. Myotest had a larger CV (range 8.9% to 13.0%), moderate ICC (range 0.64-0.79), and SEM ranging from 6.3 to 8.9 kN/m. The findings present important information for these devices and support the use of a time-efficient single trial to assess leg stiffness in the field. PMID:26959196

  15. Averaging Internal Consistency Reliability Coefficients

    ERIC Educational Resources Information Center

    Feldt, Leonard S.; Charter, Richard A.

    2006-01-01

    Seven approaches to averaging reliability coefficients are presented. Each approach starts with a unique definition of the concept of "average," and no approach is more correct than the others. Six of the approaches are applicable to internal consistency coefficients. The seventh approach is specific to alternate-forms coefficients. Although the…

  16. Tube Concept for Entangled Stiff Fibers Predicts Their Dynamics in Space and Time.

    PubMed

    Leitmann, Sebastian; Höfling, Felix; Franosch, Thomas

    2016-08-26

    We study dynamically crowded solutions of stiff fibers deep in the semidilute regime, where the motion of a single constituent becomes increasingly confined to a narrow tube. The spatiotemporal dynamics for wave numbers resolving the motion in the confining tube becomes accessible in Brownian dynamics simulations upon employing a geometry-adapted neighbor list. We demonstrate that in such crowded environments the intermediate scattering function, characterizing the motion in space and time, can be predicted quantitatively by simulating a single freely diffusing phantom needle only, yet with very unusual diffusion coefficients.

  17. Tube Concept for Entangled Stiff Fibers Predicts Their Dynamics in Space and Time.

    PubMed

    Leitmann, Sebastian; Höfling, Felix; Franosch, Thomas

    2016-08-26

    We study dynamically crowded solutions of stiff fibers deep in the semidilute regime, where the motion of a single constituent becomes increasingly confined to a narrow tube. The spatiotemporal dynamics for wave numbers resolving the motion in the confining tube becomes accessible in Brownian dynamics simulations upon employing a geometry-adapted neighbor list. We demonstrate that in such crowded environments the intermediate scattering function, characterizing the motion in space and time, can be predicted quantitatively by simulating a single freely diffusing phantom needle only, yet with very unusual diffusion coefficients. PMID:27610885

  18. Tube Concept for Entangled Stiff Fibers Predicts Their Dynamics in Space and Time

    NASA Astrophysics Data System (ADS)

    Leitmann, Sebastian; Höfling, Felix; Franosch, Thomas

    2016-08-01

    We study dynamically crowded solutions of stiff fibers deep in the semidilute regime, where the motion of a single constituent becomes increasingly confined to a narrow tube. The spatiotemporal dynamics for wave numbers resolving the motion in the confining tube becomes accessible in Brownian dynamics simulations upon employing a geometry-adapted neighbor list. We demonstrate that in such crowded environments the intermediate scattering function, characterizing the motion in space and time, can be predicted quantitatively by simulating a single freely diffusing phantom needle only, yet with very unusual diffusion coefficients.

  19. Premature aortic stiffness in systemic lupus erythematosus by transesophageal echocardiography.

    PubMed

    Roldan, C A; Joson, J; Qualls, C R; Sharrar, J; Sibbitt, W L

    2010-12-01

    To assess aortic stiffness by transesophageal echocardiography (TEE) and to determine its clinical predictors and relation to age, blood pressure, renal function, and atherosclerosis, 50 patients with systemic lupus erythematosus (SLE), 94% women, with a mean age of 38 ± 12 years, and 22 age and gender-matched healthy controls underwent clinical and laboratory evaluations and multiplane TEE to assess stiffness, intima-media thickness (IMT), and plaques of the proximal, mid, and distal descending thoracic aorta. Stiffness at each level and overall aortic stiffness by the pressure-strain elastic modulus was higher in patients than in controls after adjusting for age (overall, 8.25 ± 4.13 versus 6.1 ± 2.5 Pascal units, p = 0.01). Patients had higher aortic stiffness than controls after adjusting both groups to the same mean age, blood pressure, creatinine, and aortic IMT (p = 0.005). Neither IMT nor plaques were predictors of aortic stiffness. Moreover, normotensive patients, those without aortic plaques, and non-smokers had higher stiffness than controls (all p < 0.05). Age at SLE diagnosis and non-neurologic damage score were the only SLE-specific independent predictors of aortic stiffness (both p ≤ 0.01). Thus, increased aortic stiffness is an early manifestation of lupus vasculopathy that seems to precede the development of hypertension and atherosclerosis.

  20. Towards ultra-stiff materials: Surface effects on nanoporous materials

    SciTech Connect

    Lu, Dingjie; Xie, Yi Min; Huang, Xiaodong; Zhou, Shiwei; Li, Qing

    2014-09-08

    The significant rise in the strength and stiffness of porous materials at nanoscale cannot be described by conventional scaling laws. This letter investigates the effective Young's modulus of such materials by taking into account surface effect in a microcellular architecture designed for an ultralight material whose stiffness is an order of magnitude higher than most porous materials. We find that by considering the surface effects the predicted stiffness using Euler-Bernoulli beam theory compares well to experimental data for spongelike nanoporous gold with random microstructures. Analytical results show that, of the two factors influencing the effective Young's modulus, the residual stress is more important than the surface stiffness.

  1. Optimal chordwise stiffness profiles of self-propelled flapping fins.

    PubMed

    Kancharala, A K; Philen, M K

    2016-01-01

    The versatility of fish to adapt to different swimming requirements is attributed to their complex muscular system. Fish modulate their fin stiffness and shape for maximized performance. In this paper, optimal chordwise stiffness profiles that maximize the propulsive performance have been predicted using theoretical studies. An experimental setup has been fabricated to measure the stiffness profiles of real fish caudal fins. Chordwise varying stiffness robotic fins fabricated using carbon fiber reinforced composites (CFRC) have been tested in the water tunnel to evaluate their performance over constant stiffness fins. It is observed that the varying stiffness fins produce larger thrusts and efficiencies compared to constant stiffness fins for all the operating conditions considered in this work. A comparison of the digital image correlation (DIC) measured deformations of the fins showed that the better performance of varying stiffness fins is due to their larger curvatures and trailing edge amplitudes. These theoretical and experimental studies provide a greater understanding of the role of stiffness in fish fins for locomotion. PMID:27627992

  2. Idiopathic hypertonicity as a cause of stiffness after surgery for developmental dysplasia of the hip☆

    PubMed Central

    Akgül, Turgut; Göksan, Süleyman Bora; Eren, İlker

    2014-01-01

    INTRODUCTION There are various complications reported with surgical treatment of DDH. Most studied complication is avascular necrosis of the femoral head and hip stiffness. The purpose of this report was to describe a case with severe stiffness of the hip due to hypertonicity in periarticular muscles after it was treated for developmental dysplasia of the hip (DDH). PRESENTATION OF CASE Three-year-old patient referred to our institution with bilateral DDH. Two hips were operated separately in one year with anterior open reduction, femoral shortening osteotomy. Third month after last surgery, limited right hip range of motion and limb length discrepency identified. Clinical examination revealed that patient had limited range of motion (ROM) in the right hip and compensated this with pelvis obliquity. Gluteus medius, sartorius and iliofemoral band release performed after examination under general anesthesia. Symptoms were persisted at 3rd week control and examination of the patient in general anesthesia revealed full ROM without increased tension. For the identified hypertonicity, ultrasound guided 100 IU botulinum toxin A injection performed to abductor group and iliopsoas muscles. Fifth month later, no flexor or abductor tension observed, and there was no pelvic obliquity. DISCUSSION Stiffness as a complication is rare and is usually resolved without treatment or simple physical therapy. Usually it is related with immobilization or surgery associated joint contracture, and spontaneous recovery reported. Presented case is diagnosed as hip stiffness due to underlying local hypertonicity. That is resolved with anesthesia and it was treated after using botulinum toxin A injection. CONCLUSION Hypertonicity with hip stiffness after surgical treatment of DDH differ from spontaneous recovering hip range of motion limitation and treatment can only be achieved by reduction of the muscle hypertonicity by neuromuscular junction blockage. PMID:24568944

  3. An infinitely-stiff elastic system via a tuned negative-stiffness component stabilized by rotation-produced gyroscopic forces

    NASA Astrophysics Data System (ADS)

    Kochmann, D. M.; Drugan, W. J.

    2016-06-01

    An elastic system containing a negative-stiffness element tuned to produce positive-infinite system stiffness, although statically unstable as is any such elastic system if unconstrained, is proved to be stabilized by rotation-produced gyroscopic forces at sufficiently high rotation rates. This is accomplished in possibly the simplest model of a composite structure (or solid) containing a negative-stiffness component that exhibits all these features, facilitating a conceptually and mathematically transparent, completely closed-form analysis.

  4. The role of gravity or pressure and contact stiffness in granular rheology

    NASA Astrophysics Data System (ADS)

    Singh, Abhinendra; Magnanimo, Vanessa; Saitoh, Kuniyasu; Luding, Stefan

    2015-04-01

    The steady-state shear rheology of granular materials is investigated in slow quasistatic and inertial flows. The effect of gravity (thus the local pressure) and the often-neglected contact stiffness are the focus of this study. A series of particle simulations are performed on a weakly frictional granular assembly in a split-bottom geometry considering various magnitudes of gravity and contact stiffnesses. While traditionally the inertial number, i.e., the ratio of stress to strain-rate time scales, is used to describe the flow rheology, we report that a second dimensionless number, the ratio of softness and stress time scales, must also be included to characterize the bulk flow behavior. For slow, quasistatic flows, the density increases while the effective (macroscopic) friction decreases with increase in either particle softness or local pressure. This trend is added to the μ (I) rheology and can be traced back to the anisotropy in the contact network, displaying a linear correlation between the effective friction coefficient and deviatoric fabric in the steady state. When the external rotation rate is increased towards the inertial regime, for a given gravity field and contact stiffness, the effective friction increases faster than linearly with the deviatoric fabric.

  5. Effect of stiffness of multi-level hierarchical attachment system on adhesion enhancement.

    PubMed

    Kim, Tae Wan; Bhushan, Bharat

    2007-10-01

    Geckos are known for their remarkable ability to cling on and detach from ceilings and walls using a unique attachment system. Their foot pads are covered by a large number of small hair (setae) that contain many branches per seta with a lower level of spatulae. This hierarchical structure gives the gecko adaptability to create a large real area of contact with rough surfaces. In this study, using the three-level hierarchical model recently developed to simulate a gecko seta contacting with random rough surface, the effects of spring stiffness and number of springs on the adhesion enhancement of multi-level hierarchical model are investigated. One- and three-level hierarchically structured spring models with different spring stiffnesses and number of springs on each level in contact with various rough surfaces are considered. The efficiency of attachment-the adhesion coefficient, the adhesion force, the number of contacts and the adhesion energy-for the three-level models with different stiffness is investigated in contact with different rough surfaces.

  6. Pulmonary vascular wall stiffness: An important contributor to the increased right ventricular afterload with pulmonary hypertension

    PubMed Central

    Wang, Zhijie; Chesler, Naomi C.

    2011-01-01

    Pulmonary hypertension (PH) is associated with structural and mechanical changes in the pulmonary vascular bed that increase right ventricular (RV) afterload. These changes, characterized by narrowing and stiffening, occur in both proximal and distal pulmonary arteries (PAs). An important consequence of arterial narrowing is increased pulmonary vascular resistance (PVR). Arterial stiffening, which can occur in both the proximal and distal pulmonary arteries, is an important index of disease progression and is a significant contributor to increased RV afterload in PH. In particular, arterial narrowing and stiffening increase the RV afterload by increasing steady and oscillatory RV work, respectively. Here we review the current state of knowledge of the causes and consequences of pulmonary arterial stiffening in PH and its impact on RV function. We review direct and indirect techniques for measuring proximal and distal pulmonary arterial stiffness, measures of arterial stiffness including elastic modulus, incremental elastic modulus, stiffness coefficient β and others, the changes in cellular function and the extracellular matrix proteins that contribute to pulmonary arterial stiffening, the consequences of PA stiffening for RV function and the clinical implications of pulmonary vascular stiffening for PH progression. Future investigation of the relationship between PA stiffening and RV dysfunction may facilitate new therapies aimed at improving RV function and thus ultimately reducing mortality in PH. PMID:22034607

  7. Quantitative assessment of sample stiffness and sliding friction from force curves in atomic force microscopy

    SciTech Connect

    Pratt, Jon R.; Shaw, Gordon A.; Kumanchik, Lee; Burnham, Nancy A.

    2010-02-15

    It has long been recognized that the angular deflection of an atomic force microscope (AFM) cantilever under ''normal'' loading conditions can be profoundly influenced by the friction between the tip and the surface. It is shown here that a remarkably quantifiable hysteresis occurs in the slope of loading curves whenever the normal flexural stiffness of the AFM cantilever is greater than that of the sample. This situation arises naturally in cantilever-on-cantilever calibration, but also when trying to measure the stiffness of nanomechanical devices or test structures, or when probing any type of surface or structure that is much more compliant along the surface normal than in transverse directions. Expressions and techniques for evaluating the coefficient of sliding friction between the cantilever tip and sample from normal force curves, as well as relations for determining the stiffness of a mechanically compliant specimen are presented. The model is experimentally supported by the results of cantilever-on-cantilever spring constant calibrations. The cantilever spring constants determined here agree with the values determined using the NIST electrostatic force balance within the limits of the largest uncertainty component, which had a relative value of less than 2.5%. This points the way for quantitative testing of micromechanical and nanomechanical components, more accurate calibration of AFM force, and provides nanotribologists access to information about contact friction from normal force curves.

  8. The influence of leaflet skin friction and stiffness on the performance of bioprosthetic aortic valves.

    PubMed

    Dellimore, K; Kemp, I; Scheffer, C; Weich, H; Doubell, A

    2013-12-01

    Leaflet skin friction and stiffness were found to have a significant influence on the systolic performance of a 19 mm diameter bioprosthetic aortic valve based on fluid-structure interaction simulations at a heart rate of 72 bpm. Four different leaflet skin friction coefficients (0.0, 9.2 × 10(-4), 4.8 × 10(-2) and 4.8 × 10(-1)) were simulated along with three different leaflet elastic moduli (3.0 × 10(6), 3.5 × 10(6), 4.0 × 10(6) N m(-2)). Higher leaflet skin friction was found to increase the magnitude of the systolic transvalvular pressure gradient and the peak velocity through the valve, as well as decrease the valve orifice area. The results for the leaflet opening and closing kinematics also showed that higher leaflet skin friction combined with higher leaflet stiffness produces longer rapid valve opening, closing and ejection times, as well as smaller valve orifice areas. These results are consistent with clinical findings for calcified aortic valves and suggest that valve performance under stenotic conditions is strongly influenced by the combined effect of increasing leaflet stiffness and surface roughness caused by calcification.

  9. Effects of varying machine stiffness and contact area in UltraForm Finishing

    NASA Astrophysics Data System (ADS)

    Briggs, Dennis E.; Echaves, Samantha; Pidgeon, Brendan; Travis, Nathan; Ellis, Jonathan D.

    2013-09-01

    UltraForm Finishing (UFF) is a deterministic, subaperture, computer numerically controlled, grinding and polishing platform designed by OptiPro Systems. UFF is used to grind and polish a variety optics from simple spherical to fully freeform, and numerous materials from glasses to optical ceramics. The UFF system consists of an abrasive belt around a compliant wheel that rotates and contacts the part to remove material. This work aims to measure the stiffness variations in the system and how it can affect material removal rates. The stiffness of the entire system is evaluated using a triaxial load cell to measure forces and a capacitance sensor to measure deviations in height. Because the wheel is conformal and elastic, the shapes of contact areas are also of interest. For the scope of this work, the shape of the contact area is estimated via removal spot. The measured forces and removal spot area are directly related to material removal rate through Preston's equation. Using our current testing apparatus, we will demonstrate stiffness measurements and contact areas for a single UFF belt during different states of its lifecycle and assess the material removal function from spot diagrams as a function of wear. This investigation will ultimately allow us to make better estimates of Preston's coefficient and develop spot-morphing models in an effort to more accurately predict instantaneous material removal functions throughout the lifetime of a belt.

  10. Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation

    PubMed Central

    Mattei, Giorgio; Ferretti, Concetta; Tirella, Annalisa; Ahluwalia, Arti; Mattioli-Belmonte, Monica

    2015-01-01

    Bone extracellular matrix (ECM) is a natural composite made of collagen and mineral hydroxyapatite (HA). Dynamic cell-ECM interactions play a critical role in regulating cell differentiation and function. Understanding the principal ECM cues promoting osteogenic differentiation would be pivotal for both bone tissue engineering and regenerative medicine. Altering the mineral content generally modifies the stiffness as well as other physicochemical cues provided by composite materials, complicating the “cause-effect” analysis of resultant cell behaviour. To isolate the contribution of mechanical cues from other HA-derived signals, we developed and characterised composite HA/gelatin scaffolds with different mineral contents along with a set of stiffness-matched HA-free gelatin scaffolds. Samples were seeded with human periosteal derived progenitor cells (PDPCs) and cultured over 7 days, analysing their resultant morphology and gene expression. Our results show that both stiffness and HA contribute to directing PDPC osteogenic differentiation, highlighting the role of stiffness in triggering the expression of osteogenic genes and of HA in accelerating the process, particularly at high concentrations. PMID:26035412

  11. Aortic Compliance and Stiffness Among Severe Longstanding Hypertensive and Non-hypertensive

    PubMed Central

    Kamberi, Lulzim Selim; Gorani, Daut Rashit; Hoxha, Teuta Faik; Zahiti, Bedri Faik

    2013-01-01

    Introduction Abnormal aortic function in hypertension is generally attributed to accelerated breakdown of elastin in the aorta, leading to dilatation of the lumen and stiffening of the wall as elastin is replaced with stiffer collagen. Aortic stiffness is an independent predictor of cardiovascular risk and all-cause and cardiovascular mortality. Vascular stiffening can activate endothelium which in turn may promote atherogenesis. Modulation of arterial stiffness has been shown to be successfully managed via changes in lifestyle and put under control of hypertension pharmacologically with antihypertensive drugs and statins. Methods Hundred and forty four patients have been enrolled in this study. They have been divided in two groups, with hypertension and group of control. Groups were with no age difference. Results Group with hypertension were with reduced aortic strain, distensibility (compliance) and have higher stiffness than control group; GrHTA =9.3 compared to GC=5.4. After successful treatment of hypertension with antihypertensives and statins, for two years, these parameters showed improvement, but still remain out of normal range compared to control group; 7.6 vs. 5.38. Conclusions Hypertensive patients have reduced aortic elasticity and increased stiffness which can be stopped and improved after treatment with antihypertensive and statin. PMID:23572854

  12. Evaluation of Compressive Strength and Stiffness of Grouted Soils by Using Elastic Waves

    PubMed Central

    Lee, In-Mo; Kim, Jong-Sun; Yoon, Hyung-Koo; Lee, Jong-Sub

    2014-01-01

    Cement grouted soils, which consist of particulate soil media and cementation agents, have been widely used for the improvement of the strength and stiffness of weak ground and for the prevention of the leakage of ground water. The strength, elastic modulus, and Poisson's ratio of grouted soils have been determined by classical destructive methods. However, the performance of grouted soils depends on several parameters such as the distribution of particle size of the particulate soil media, grouting pressure, curing time, curing method, and ground water flow. In this study, elastic wave velocities are used to estimate the strength and elastic modulus, which are generally obtained by classical strength tests. Nondestructive tests by using elastic waves at small strain are conducted before and during classical strength tests at large strain. The test results are compared to identify correlations between the elastic wave velocity measured at small strain and strength and stiffness measured at large strain. The test results show that the strength and stiffness have exponential relationship with elastic wave velocities. This study demonstrates that nondestructive methods by using elastic waves may significantly improve the strength and stiffness evaluation processes of grouted soils. PMID:25025082

  13. Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation.

    PubMed

    Mattei, Giorgio; Ferretti, Concetta; Tirella, Annalisa; Ahluwalia, Arti; Mattioli-Belmonte, Monica

    2015-01-01

    Bone extracellular matrix (ECM) is a natural composite made of collagen and mineral hydroxyapatite (HA). Dynamic cell-ECM interactions play a critical role in regulating cell differentiation and function. Understanding the principal ECM cues promoting osteogenic differentiation would be pivotal for both bone tissue engineering and regenerative medicine. Altering the mineral content generally modifies the stiffness as well as other physicochemical cues provided by composite materials, complicating the "cause-effect" analysis of resultant cell behaviour. To isolate the contribution of mechanical cues from other HA-derived signals, we developed and characterised composite HA/gelatin scaffolds with different mineral contents along with a set of stiffness-matched HA-free gelatin scaffolds. Samples were seeded with human periosteal derived progenitor cells (PDPCs) and cultured over 7 days, analysing their resultant morphology and gene expression. Our results show that both stiffness and HA contribute to directing PDPC osteogenic differentiation, highlighting the role of stiffness in triggering the expression of osteogenic genes and of HA in accelerating the process, particularly at high concentrations. PMID:26035412

  14. Homogenized stiffness matrices for mineralized collagen fibrils and lamellar bone using unit cell finite element models.

    PubMed

    Vercher, Ana; Giner, Eugenio; Arango, Camila; Tarancón, José E; Fuenmayor, F Javier

    2014-04-01

    Mineralized collagen fibrils have been usually analyzed like a two-phase composite material where crystals are considered as platelets that constitute the reinforcement phase. Different models have been used to describe the elastic behavior of the material. In this work, it is shown that when Halpin-Tsai equations are applied to estimate elastic constants from typical constituent properties, not all crystal dimensions yield a model that satisfy thermodynamic restrictions. We provide the ranges of platelet dimensions that lead to positive definite stiffness matrices. On the other hand, a finite element model of a mineralized collagen fibril unit cell under periodic boundary conditions is analyzed. By applying six canonical load cases, homogenized stiffness matrices are numerically calculated. Results show a monoclinic behavior of the mineralized collagen fibril. In addition, a 5-layer lamellar structure is also considered where crystals rotate in adjacent layers of a lamella. The stiffness matrix of each layer is calculated applying Lekhnitskii transformations, and a new finite element model under periodic boundary conditions is analyzed to calculate the homogenized 3D anisotropic stiffness matrix of a unit cell of lamellar bone. Results are compared with the rule-of-mixtures showing in general good agreement. PMID:23793930

  15. Homogenized stiffness matrices for mineralized collagen fibrils and lamellar bone using unit cell finite element models.

    PubMed

    Vercher, Ana; Giner, Eugenio; Arango, Camila; Tarancón, José E; Fuenmayor, F Javier

    2014-04-01

    Mineralized collagen fibrils have been usually analyzed like a two-phase composite material where crystals are considered as platelets that constitute the reinforcement phase. Different models have been used to describe the elastic behavior of the material. In this work, it is shown that when Halpin-Tsai equations are applied to estimate elastic constants from typical constituent properties, not all crystal dimensions yield a model that satisfy thermodynamic restrictions. We provide the ranges of platelet dimensions that lead to positive definite stiffness matrices. On the other hand, a finite element model of a mineralized collagen fibril unit cell under periodic boundary conditions is analyzed. By applying six canonical load cases, homogenized stiffness matrices are numerically calculated. Results show a monoclinic behavior of the mineralized collagen fibril. In addition, a 5-layer lamellar structure is also considered where crystals rotate in adjacent layers of a lamella. The stiffness matrix of each layer is calculated applying Lekhnitskii transformations, and a new finite element model under periodic boundary conditions is analyzed to calculate the homogenized 3D anisotropic stiffness matrix of a unit cell of lamellar bone. Results are compared with the rule-of-mixtures showing in general good agreement.

  16. Cellular mechanoadaptation to substrate mechanical properties: contributions of substrate stiffness and thickness to cell stiffness measurements using AFM.

    PubMed

    Vichare, Shirish; Sen, Shamik; Inamdar, Mandar M

    2014-02-28

    Mechanosensing by adherent cells is usually studied by quantifying cell responses on hydrogels that are covalently linked to a rigid substrate. Atomic force microscopy (AFM) represents a convenient way of characterizing the mechanoadaptation response of adherent cells on hydrogels of varying stiffness and thickness. Since AFM measurements reflect the effective cell stiffness, therefore, in addition to measuring real cytoskeletal alterations across different conditions, these measurements might also be influenced by the geometry and physical properties of the substrate itself. To better understand how the physical attributes of the gel influence AFM stiffness measurements of cells, we have used finite element analysis to simulate the indentation of cells of various spreads resting on hydrogels of varying stiffness and thickness. Consistent with experimental results, our simulation results indicate that for well spread cells, stiffness values are significantly over-estimated when experiments are performed on cells cultured on soft and thin gels. Using parametric studies, we have developed scaling relationships between the effective stiffness probed by AFM and the bulk cell stiffness, taking cell and tip geometry, hydrogel properties, nuclear stiffness and cell contractility into account. Finally, using simulated mechanoadaptation responses, we have demonstrated that a cell stiffening response may arise purely due to the substrate properties. Collectively, our results demonstrate the need to take hydrogel properties into account while estimating cell stiffness using AFM indentation. PMID:24651595

  17. Vibration control via stiffness switching of magnetostrictive transducers

    NASA Astrophysics Data System (ADS)

    Scheidler, Justin J.; Asnani, Vivake M.; Dapino, Marcelo J.

    2016-04-01

    In this paper, a computational study is presented of structural vibration control that is realized by switching a magneto-strictive transducer between high and low stiffness states. Switching is accomplished by either changing the applied magnetic field with a voltage excitation or changing the shunt impedance on the transducer's coil (i.e., the magneto-strictive material's magnetic boundary condition). Switched-stiffness vibration control is simulated using a lumped mass supported by a damper and the magneto-strictive transducer (mount), which is represented by a nonlinear, electromechanical model. Free vibration of the mass is calculated while varying the mount's stiffness according to a reference switched-stiffness vibration control law. The results reveal that switching the magnetic field produces the desired change in stiffness, but also an undesired actuation force that can significantly degrade the vibration control. Hence, a modified switched-stiffness control law that accounts for the actuation force is proposed and implemented for voltage-controlled stiffness switching. The influence of the magneto-mechanical bias condition is also discussed. Voltage-controlled stiffness switching is found to introduce damping equivalent to a viscous damping factor up to about 0.13; this is shown to primarily result from active vibration reduction caused by the actuation force. The merit of magneto-strictive switched-stiffness vibration control is then quantified by comparing the results of voltage- and shunt-controlled stiffness switching to the performance of optimal magneto-strictive shunt damping. For the cases considered, optimal resistive shunt damping performed considerably better than both voltage- and shunt-controlled stiffness switching.

  18. Vibration Control via Stiffness Switching of Magnetostrictive Transducers

    NASA Technical Reports Server (NTRS)

    Scheidler, Justin J.; Asnani, Vivake M.; Dapino, Marcelo J.

    2016-01-01

    In this paper, a computational study is presented of structural vibration control that is realized by switching a magnetostrictive transducer between high and low stiffness states. Switching is accomplished by either changing the applied magnetic field with a voltage excitation or changing the shunt impedance on the transducer's coil (i.e., the magnetostrictive material's magnetic boundary condition). Switched-stiffness vibration control is simulated using a lumped mass supported by a damper and the magnetostrictive transducer (mount), which is represented by a nonlinear, electromechanical model. Free vibration of the mass is calculated while varying the mount's stiffness according to a reference switched-stiffness vibration control law. The results reveal that switching the magnetic field produces the desired change in stiffness, but also an undesired actuation force that can significantly degrade the vibration control. Hence, a modified switched-stiffness control law that accounts for the actuation force is proposed and implemented for voltage-controlled stiffness switching. The influence of the magneto-mechanical bias condition is also discussed. Voltage-controlled stiffness switching is found to introduce damping equivalent to a viscous damping factor up to about 0.13; this is shown to primarily result from active vibration reduction caused by the actuation force. The merit of magnetostrictive switched-stiffness vibration control is then quantified by comparing the results of voltage- and shunt-controlled stiffness switching to the performance of optimal magnetostrictive shunt damping. For the cases considered, optimal resistive shunt damping performed considerably better than both voltage- and shunt-controlled stiffness switching.

  19. Three-dimensional stiffness of the carpal arch.

    PubMed

    Gabra, Joseph N; Li, Zong-Ming

    2016-01-01

    The carpal arch of the wrist is formed by irregularly shaped carpal bones interconnected by numerous ligaments, resulting in complex structural mechanics. The purpose of this study was to determine the three-dimensional stiffness characteristics of the carpal arch using displacement perturbations. It was hypothesized that the carpal arch would exhibit an anisotropic stiffness behavior with principal directions that are oblique to the conventional anatomical axes. Eight (n=8) cadavers were used in this study. For each specimen, the hamate was fixed to a custom stationary apparatus. An instrumented robot arm applied three-dimensional displacement perturbations to the ridge of trapezium and corresponding reaction forces were collected. The displacement-force data were used to determine a three-dimensional stiffness matrix using least squares fitting. Eigendecomposition of the stiffness matrix was used to identify the magnitudes and directions of the principal stiffness components. The carpal arch structure exhibited anisotropic stiffness behaviors with a maximum principal stiffness of 16.4±4.6N/mm that was significantly larger than the other principal components of 3.1±0.9 and 2.6±0.5N/mm (p<0.001). The principal direction of the maximum stiffness was pronated within the cross section of the carpal tunnel which is accounted for by the stiff transverse ligaments that tightly bind distal carpal arch. The minimal principal stiffness is attributed to the less constraining articulation between the trapezium and scaphoid. This study provides advanced characterization of the wrist׳s three-dimensional structural stiffness for improved insight into wrist biomechanics, stability, and function.

  20. Tachocline dynamics: convective overshoot at stiff interfaces

    NASA Astrophysics Data System (ADS)

    Brown, Benjamin; Lecoanet, Daniel; Oishi, Jeffrey S.; Burns, Keaton; Vasil, Geoffrey M.

    2016-05-01

    The solar tachocline lies at the base of the solar convection zone. At this internal interface, motions from the unstable convection zone above overshoot and penetrate downward into the stiffly stable radiative zone below, driving gravity waves, mixing, and possibly pumping and storing magnetic fields. Here we study the dynamics of convective overshoot across very stiff interfaces with some properties similar to the internal boundary layer within the Sun. We use the Dedalus pseudospectral framework and study fully compressible dynamics at moderate to high Peclet number and low Mach number, probing a regime where turbulent transport is important. In this preliminary work, we find that the depth of convective overshoot is well described by a simple buoyancy equilibration model, and we consider implications for dynamics at the solar tachocline.

  1. Stiff-person syndrome treated with rituximab

    PubMed Central

    Lobo, Marcelo Evangelista; Araújo, Marx Lincoln Barros; Tomaz, Carlos Alberto Bezerra; Allam, Nasser

    2010-01-01

    Stiff-person syndrome (SPS) is a rare neurological condition consisting of progressive and fluctuating rigidity of the axial muscles combined with painful spasms. The pathophysiology of SPS is not fully understood, but there seems to be an autoimmune component. The use of rituximab, a chimeric monoclonal antibody targeting CD20 protein in the surface of mature B cells, for the treatment of SPS is a recent therapeutical approach showing promising results. The authors present a case report of a 41-year-old female patient diagnosed with SPS who was treated with rituximab in a public hospital in Brasília, Brazil, showing a good and safe response to the treatment so far. Our data go along with some recent articles published in the literature. PMID:22802263

  2. Stiffness control of balance in quiet standing.

    PubMed

    Winter, D A; Patla, A E; Prince, F; Ishac, M; Gielo-Perczak, K

    1998-09-01

    Our goal was to provide some insights into how the CNS controls and maintains an upright standing posture, which is an integral part of activities of daily living. Although researchers have used simple performance measures of maintenance of this posture quite effectively in clinical decision making, the mechanisms and control principles involved have not been clear. We propose a relatively simple control scheme for regulation of upright posture that provides almost instantaneous corrective response and reduces the operating demands on the CNS. The analytic model is derived and experimentally validated. A stiffness model was developed for quiet standing. The model assumes that muscles act as springs to cause the center-of-pressure (COP) to move in phase with the center-of-mass (COM) as the body sways about some desired position. In the sagittal plane this stiffness control exists at the ankle plantarflexors, in the frontal plane by the hip abductors/adductors. On the basis of observations that the COP-COM error signal continuously oscillates, it is evident that the inverted pendulum model is severely underdamped, approaching the undamped condition. The spectrum of this error signal is seen to match that of a tuned mass, spring, damper system, and a curve fit of this "tuned circuit" yields omega n the undamped natural frequency of the system. The effective stiffness of the system, Ke, is then estimated from Ke = I omega n2, and the damping B is estimated from B = BW X I, where BW is the bandwidth of the tuned response (in rad/s), and I is the moment of inertia of the body about the ankle joint. Ten adult subjects were assessed while standing quietly at three stance widths: 50% hip-to-hip distance, 100 and 150%. Subjects stood for 2 min in each position with eyes open; the 100% stance width was repeated with eyes closed. In all trials and in both planes, the COP oscillated virtually in phase (within 6 ms) with COM, which was predicted by a simple 0th order spring

  3. A parallel algorithm for generation and assembly of finite element stiffness and mass matrices

    NASA Technical Reports Server (NTRS)

    Storaasli, O. O.; Carmona, E. A.; Nguyen, D. T.; Baddourah, M. A.

    1991-01-01

    A new algorithm is proposed for parallel generation and assembly of the finite element stiffness and mass matrices. The proposed assembly algorithm is based on a node-by-node approach rather than the more conventional element-by-element approach. The new algorithm's generality and computation speed-up when using multiple processors are demonstrated for several practical applications on multi-processor Cray Y-MP and Cray 2 supercomputers.

  4. Mechanically stiff, electrically conductive composites of polymers and carbon nanotubes

    SciTech Connect

    Worsley, Marcus A.; Kucheyev, Sergei O.; Baumann, Theodore F.; Kuntz, Joshua D.; Satcher, Jr., Joe H.; Hamza, Alex V.

    2015-07-21

    Using SWNT-CA as scaffolds to fabricate stiff, highly conductive polymer (PDMS) composites. The SWNT-CA is immersing in a polymer resin to produce a SWNT-CA infiltrated with a polymer resin. The SWNT-CA infiltrated with a polymer resin is cured to produce the stiff and electrically conductive composite of carbon nanotube aerogel and polymer.

  5. The dynamic effect of muscle activation on knee stiffness.

    PubMed

    Ludvig, Daniel; Perreault, Eric J

    2014-01-01

    Adapting limb mechanics in a task and environment dependent manner is one component of human motor control. Joint mechanics have been extensively studied under static postural conditions, but less so under time-varying movement conditions. The limited studies that have investigated joint mechanics during movement, have found a drop in joint stiffness during movement, however the source of this decrease in stiffness remains unknown. Here in this paper we investigate whether time-varying muscle activation, which occurs during volitional movement, can lead to the drop in stiffness seen during movement. We found that under time-varying isometric conditions stiffness dropped when subjects transitioned from extension to flexion and vice-versa, a phenomenon that could not be explained by simply superimposing extension and flexion contractions. These findings suggest that dynamics of muscle activation may be responsible for the complex pattern of stiffness changes seen during simple movements. Furthermore, these results imply that EMG-based estimates of stiffness, which work well for steady-state postural conditions, will need to be augmented to account for the highly non-linear relationship between muscle activation and stiffness before they can also be used to estimate stiffness during dynamic contractions.

  6. Boundary Stiffness Regulates Fibroblast Behavior in Collagen Gels

    PubMed Central

    John, Jeffrey; Quinlan, Angela Throm; Silvestri, Chiara; Billiar, Kristen

    2010-01-01

    Recent studies have illustrated the profound dependence of cellular behavior on the stiffness of 2D culture substrates. The goal of this study was to develop a method to alter the stiffness cells experience in a standard 3D collagen gel model without affecting the physiochemical properties of the extracellular matrix. A device was developed utilizing compliant anchors (0.048–0.64 N m−1) to tune the boundary stiffness of suspended collagen gels in between the commonly utilized free and fixed conditions (zero and infinite stiffness boundary stiffness). We demonstrate the principle of operation with finite element analyses and a wide range of experimental studies. In all cases, boundary stiffness has a strong influence on cell behavior, most notably eliciting higher basal tension and activated force (in response to KCl) and more pronounced remodeling of the collagen matrix at higher boundary stiffness levels. Measured equibiaxial forces for gels seeded with 3 million human foreskin fibroblasts range from 0.05 to 1 mN increasing monotonically with boundary stiffness. Estimated force per cell ranges from 17 to 100 nN utilizing representative volume element analysis. This device provides a valuable tool to independently study the effect of the mechanical environment of the cell in a 3D collagen matrix. PMID:20012205

  7. Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation

    PubMed Central

    Hwang, Jun-Ha; Byun, Mi Ran; Kim, A. Rum; Kim, Kyung Min; Cho, Hang Jun; Lee, Yo Han; Kim, Juwon; Jeong, Mi Gyeong; Hwang, Eun Sook; Hong, Jeong-Ho

    2015-01-01

    Mesenchymal stem cell (MSC) differentiation is regulated by the extracellular matrix (ECM) through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif (TAZ) was identified as an effector protein for MSC differentiation. However, the detailed underlying mechanism regarding the role of ECM stiffness and TAZ in MSC differentiation is not yet fully understood. In this report, we showed that ECM stiffness regulates MSC fate through ERK or JNK activation. Specifically, a stiff hydrogel matrix stimulates osteogenic differentiation concomitant with increased nuclear localization of TAZ, but inhibits adipogenic differentiation. ERK and JNK activity was significantly increased in cells cultured on a stiff hydrogel. TAZ activation was induced by ERK or JNK activation on a stiff hydrogel because exposure to an ERK or JNK inhibitor significantly decreased the nuclear localization of TAZ, indicating that ECM stiffness-induced ERK or JNK activation is important for TAZ-driven osteogenic differentiation. Taken together, these results suggest that ECM stiffness regulates MSC differentiation through ERK or JNK activation. PMID:26262877

  8. Extracellular Matrix Stiffness Regulates Osteogenic Differentiation through MAPK Activation.

    PubMed

    Hwang, Jun-Ha; Byun, Mi Ran; Kim, A Rum; Kim, Kyung Min; Cho, Hang Jun; Lee, Yo Han; Kim, Juwon; Jeong, Mi Gyeong; Hwang, Eun Sook; Hong, Jeong-Ho

    2015-01-01

    Mesenchymal stem cell (MSC) differentiation is regulated by the extracellular matrix (ECM) through activation of intracellular signaling mediators. The stiffness of the ECM was shown to be an important regulatory factor for MSC differentiation, and transcriptional coactivator with PDZ-binding motif (TAZ) was identified as an effector protein for MSC differentiation. However, the detailed underlying mechanism regarding the role of ECM stiffness and TAZ in MSC differentiation is not yet fully understood. In this report, we showed that ECM stiffness regulates MSC fate through ERK or JNK activation. Specifically, a stiff hydrogel matrix stimulates osteogenic differentiation concomitant with increased nuclear localization of TAZ, but inhibits adipogenic differentiation. ERK and JNK activity was significantly increased in cells cultured on a stiff hydrogel. TAZ activation was induced by ERK or JNK activation on a stiff hydrogel because exposure to an ERK or JNK inhibitor significantly decreased the nuclear localization of TAZ, indicating that ECM stiffness-induced ERK or JNK activation is important for TAZ-driven osteogenic differentiation. Taken together, these results suggest that ECM stiffness regulates MSC differentiation through ERK or JNK activation.

  9. ECM stiffness primes the TGFβ pathway to promote chondrocyte differentiation

    PubMed Central

    Allen, Jessica L.; Cooke, Margaret E.; Alliston, Tamara

    2012-01-01

    Cells encounter physical cues such as extracellular matrix (ECM) stiffness in a microenvironment replete with biochemical cues. However, the mechanisms by which cells integrate physical and biochemical cues to guide cellular decision making are not well defined. Here we investigate mechanisms by which chondrocytes generate an integrated response to ECM stiffness and transforming growth factor β (TGFβ), a potent agonist of chondrocyte differentiation. Primary murine chondrocytes and ATDC5 cells grown on 0.5-MPa substrates deposit more proteoglycan and express more Sox9, Col2α1, and aggrecan mRNA relative to cells exposed to substrates of any other stiffness. The chondroinductive effect of this discrete stiffness, which falls within the range reported for articular cartilage, requires the stiffness-sensitive induction of TGFβ1. Smad3 phosphorylation, nuclear localization, and transcriptional activity are specifically increased in cells grown on 0.5-MPa substrates. ECM stiffness also primes cells for a synergistic response, such that the combination of ECM stiffness and exogenous TGFβ induces chondrocyte gene expression more robustly than either cue alone through a p38 mitogen-activated protein kinase–dependent mechanism. In this way, the ECM stiffness primes the TGFβ pathway to efficiently promote chondrocyte differentiation. This work reveals novel mechanisms by which cells integrate physical and biochemical cues to exert a coordinated response to their unique cellular microenvironment. PMID:22833566

  10. Neuromuscular and stiffness adaptations in division I collegiate baseball players.

    PubMed

    Thomas, Stephen J; Swanik, Charles B; Higginson, Jill S; Kaminski, Thomas W; Swanik, Kathleen A; Kelly, John D; Nazarian, Levon N

    2013-02-01

    To compare bi-lateral shoulder EMG, active and short range glenohumeral stiffness, and examine its correlation to posterior capsule thickness (PCT) in collegiate baseball players. Surface and fine wire EMG was recorded on shoulder and scapular musculature during stiffness testing. Posterior capsule thickness was assessed separately using a diagnostic ultrasound. Serratus anterior EMG area and peak on the dominant arm was significantly greater compared to the non-dominant arm. The dominant arm had significantly greater active and short range glenohumeral stiffness compared to the non-dominant arm. Active glenohumeral stiffness was significantly correlated with PCT, however short range glenohumeral stiffness was not significantly correlated with PCT. Healthy collegiate baseball players present with adaptations of their stiffness regulation strategies. There were also correlations between stiffness and morphologic changes. Our results support the theory that PCT has an impact on the energy absorption capabilities of the shoulder during the deceleration phase of throwing. It also seems that tightening of the series elastic component within the posterior rotator cuff may be causing the increase in short range stiffness on the dominant arm.

  11. Neuromuscular and stiffness adaptations in division I collegiate baseball players.

    PubMed

    Thomas, Stephen J; Swanik, Charles B; Higginson, Jill S; Kaminski, Thomas W; Swanik, Kathleen A; Kelly, John D; Nazarian, Levon N

    2013-02-01

    To compare bi-lateral shoulder EMG, active and short range glenohumeral stiffness, and examine its correlation to posterior capsule thickness (PCT) in collegiate baseball players. Surface and fine wire EMG was recorded on shoulder and scapular musculature during stiffness testing. Posterior capsule thickness was assessed separately using a diagnostic ultrasound. Serratus anterior EMG area and peak on the dominant arm was significantly greater compared to the non-dominant arm. The dominant arm had significantly greater active and short range glenohumeral stiffness compared to the non-dominant arm. Active glenohumeral stiffness was significantly correlated with PCT, however short range glenohumeral stiffness was not significantly correlated with PCT. Healthy collegiate baseball players present with adaptations of their stiffness regulation strategies. There were also correlations between stiffness and morphologic changes. Our results support the theory that PCT has an impact on the energy absorption capabilities of the shoulder during the deceleration phase of throwing. It also seems that tightening of the series elastic component within the posterior rotator cuff may be causing the increase in short range stiffness on the dominant arm. PMID:22898532

  12. Serum Phospholipid Docosahexaenoic Acid Is Inversely Associated with Arterial Stiffness in Metabolically Healthy Men

    PubMed Central

    Lee, Mi-Hyang; Kwon, Nayeon; Yoon, So Ra

    2016-01-01

    We hypothesized that lower proportion of serum phospholipid docosahexaenoic acid (DHA) is inversely associated with increased cardiovascular risk and vascular function in metabolically healthy men. To elucidate it, we first compared serum phospholipid free fatty acid (FA) compositions and cardiovascular risk parameters between healthy men (n = 499) and male patients with coronary artery disease (CAD, n = 111) (30-69 years) without metabolic syndrome, and then further-analyzed the association of serum phospholipid DHA composition with arterial stiffness expressed by brachial-ankle pulse wave velocity (ba-PWV) in metabolically healthy men. Basic parameters, lipid profiles, fasting glycemic status, adiponectin, high sensitivity C-reactive protein (hs-CRP) and LDL particle size, and serum phospholipid FA compositions were significantly different between the two subject groups. Serum phospholipid DHA was highly correlated with most of long-chain FAs. Metabolically healthy men were subdivided into tertile groups according to serum phospholipid DHA proportion: lower (< 2.061%), middle (2.061%-3.235%) and higher (> 3.235%). Fasting glucose, insulin resistance, hs-CRP and ba-PWVs were significantly higher and adiponectin and LDL particle size were significantly lower in the lower-DHA group than the higher-DHA group after adjusted for confounding factors. In metabolically healthy men, multiple stepwise regression analysis revealed that serum phospholipid DHA mainly contributed to arterial stiffness (β′-coefficients = -0.127, p = 0.006) together with age, systolic blood pressure, triglyceride (r = 0.548, p = 0.023). Lower proportion of serum phospholipid DHA was associated with increased cardiovascular risk and arterial stiffness in metabolically healthy men. It suggests that maintaining higher proportion of serum phospholipid DHA may be beneficial for reducing cardiovascular risk including arterial stiffness in metabolically healthy men. PMID:27482523

  13. Passive mechanical models of fish caudal fins: effects of shape and stiffness on self-propulsion.

    PubMed

    Feilich, Kara L; Lauder, George V

    2015-06-01

    Fishes are found in a great variety of body forms with tail shapes that vary from forked tuna-like tails to the square-shaped tails found in some deep-bodied species. Hydrodynamic theory suggests that a fish's body and tail shape affects undulatory swimming performance. For example, a narrow caudal peduncle is believed to reduce drag, and a tuna-like tail to increase thrust. Despite the prevalence of these assertions, there is no experimental verification of the hydrodynamic mechanisms that may confer advantages on specific forms. Here, we use a mechanically-actuated flapping foil model to study how two aspects of shape, caudal peduncle depth and presence or absence of a forked caudal fin, may affect different aspects of swimming performance. Four different foil shapes were each made of plastics of three different flexural stiffnesses, permitting us to study how shape might interact with stiffness to produce swimming performance. For each foil, we measured the self-propelling swimming speed. In addition, we measured the forces, torques, cost of transport and power coefficient of each foil swimming at its self-propelling speed. There was no single 'optimal' foil exhibiting the highest performance in all metrics, and for almost all measures of swimming performance, foil shape and flexural stiffness interacted in complicated ways. Particle image velocimetry of several foils suggested that stiffness might affect the relative phasing of the body trailing edge and the caudal fin leading edge, changing the flow incident to the tail, and affecting hydrodynamics of the entire foil. The results of this study of a simplified model of fish body and tail morphology suggest that considerable caution should be used when inferring a swimming performance advantage from body and tail shape alone. PMID:25879846

  14. A simplified procedure for mass and stiffness estimation of existing structures

    NASA Astrophysics Data System (ADS)

    Nigro, Antonella; Ditommaso, Rocco; Carlo Ponzo, Felice; Salvatore Nigro, Domenico

    2016-04-01

    This work focuses the attention on a parametric method for mass and stiffness identification of framed structures, based on frequencies evaluation. The assessment of real structures is greatly affected by the consistency of information retrieved on materials and on the influence of both non-structural components and soil. One of the most important matter is the correct definition of the distribution, both in plan and in elevation, of mass and stiffness: depending on concentrated and distributed loads, the presence of infill panels and the distribution of structural elements. In this study modal identification is performed under several mass-modified conditions and structural parameters consistent with the identified modal parameters are determined. Modal parameter identification of a structure before and after the introduction of additional masses is conducted. By considering the relationship between the additional masses and modal properties before and after the mass modification, structural parameters of a damped system, i.e. mass, stiffness and damping coefficient are inversely estimated from these modal parameters variations. The accuracy of the method can be improved by using various mass-modified conditions. The proposed simplified procedure has been tested on both numerical and experimental models by means linear numerical analyses and shaking table tests performed on scaled structures at the Seismic Laboratory of the University of Basilicata (SISLAB). Results confirm the effectiveness of the proposed procedure to estimate masses and stiffness of existing real structures with a maximum error equal to 10%, under the worst conditions. Acknowledgements This study was partially funded by the Italian Civil Protection Department within the project DPC-RELUIS 2015 - RS4 ''Seismic observatory of structures and health monitoring''.

  15. Ambulatory arterial stiffness index derived from 24-hour ambulatory blood pressure monitoring.

    PubMed

    Li, Yan; Wang, Ji-Guang; Dolan, Eamon; Gao, Ping-Jin; Guo, Hui-Feng; Nawrot, Tim; Stanton, Alice V; Zhu, Ding-Liang; O'Brien, Eoin; Staessen, Jan A

    2006-03-01

    We hypothesized that 1 minus the slope of diastolic on systolic pressure during 24-hour ambulatory monitoring (ambulatory arterial stiffness index [AASI]) might reflect arterial stiffness. We compared AASI with established measures of arterial stiffness and studied its distribution in Chinese and European populations. We used 90207 SpaceLabs monitors and the SphygmoCor device to measure AASI, central and peripheral pulse pressures, the central (CAIx) and peripheral (PAIx) systolic augmentation indexes, and aortic pulse wave velocity. In 166 volunteers, the correlation coefficient between AASI and pulse wave velocity was 0.51 (P<0.0001). In 348 randomly recruited Chinese subjects, AASI correlated (P<0.0001) with CAIx (r=0.48), PAIx (r=0.50), and central pulse pressure (r=0.50). AASI increased with age and mean arterial pressure but decreased with body height. Both before and after adjustment for arterial wave reflections by considering height and heart rate as covariates, AASI correlated more (P<0.0001) closely with CAIx and PAIx than 24-hour pulse pressure. Among normotensive subjects, the 95th percentile of AASI was 0.55 in Chinese and 0.57 in 1617 Europeans enrolled in the International Database on Ambulatory Blood Pressure Monitoring. The upper boundary of the 95% prediction interval of AASI in relation to age ranged from 0.53 at 20 years to 0.72 at 80 years. In conclusion, AASI is a new index of arterial stiffness that can be easily measured under ambulatory conditions. Pending additional validation in outcome studies, normal values of AASI are probably <0.50 and 0.70 in young and older subjects, respectively. PMID:16432048

  16. Robust Position Control of End-Effector Considering Gear Stiffness and Arm Stiffness for Industrial Robot

    NASA Astrophysics Data System (ADS)

    Tungpataratanawong, Somsawas; Chitbanchong, Satit; Miyazaki, Toshimasa; Katsura, Seiichiro; Ohishi, Kiyoshi

    Industrial robot with two-inertia model and resonant vibration suppression by using parameters from resonant identification method are addressed in this paper. By using only D-PD control with vibration suppression scheme for two-inertia model of flexible joint robot, the end-effector position does not perfectly reach the desired position owing to the effect of external force to the elastic arm. However, only gear stiffness parameter of two-inertia model is not enough, the new equivalent spring constant parameter including the stiffness of link and gear of the robot is introduced as the total arm spring constant. The novel load-side disturbance compensation considering total arm elasticity is proposed in this paper. The proposed control system is based on inner-loop vibration suppression feedback control and load-side disturbance suppression which motivates the simple consideration of the elastic joint under external torque. Moreover, the experimental results show the effectiveness of the proposed robust position control of end-effector with disturbance compensation considering total arm stiffness. The experimentation on workspace impedance control with inner-loop disturbance suppression implementing on the three degree-of-freedom (3-DOF) robot manipulator is also presented and discussed. The performance and feasibility of the proposed position control of end-effector is confirmed to apply to industrial robot manipulator without additional device.

  17. In vivo measurement of bending stiffness in fracture healing

    PubMed Central

    Hente, Reiner; Cordey, Jacques; Perren, Stephan M

    2003-01-01

    Background Measurement of the bending stiffness a healing fracture represents a valid variable in the assessment of fracture healing. However, currently available methods typically have high measurement errors, even for mild pin loosening. Furthermore, these methods cannot provide actual values of bending stiffness, which precludes comparisons among individual fractures. Thus, even today, little information is available with regards to the fracture healing pattern with respect to actual values of bending stiffness. Our goals were, therefore: to develop a measurement device that would allow accurate and sensitive measurement of bending stiffness, even in the presence of mild pin loosening; to describe the course of healing in individual fractures; and help to evaluate whether the individual pattern of bending stiffness can be predicted at an early stage of healing. Methods A new measurement device has been developed to precisely measure the bending stiffness of the healing fracture by simulating four-point-bending. The system was calibrated on aluminum models and intact tibiae. The influence of pin loosening on measurement error was evaluated. The system was tested at weekly intervals in an animal experiment to determine the actual bending stiffness of the fracture. Transverse fractures were created in the right tibia of twelve sheep, and then stabilized with an external fixator. At ten weeks, bending stiffness of the tibiae were determined in a four-point-bending test device to validate the in-vivo-measurement data. Results In-vivo bending stiffness can be measured accurately and sensitive, even in the early phase of callus healing. Up to a bending stiffness of 10 Nm/degree, measurement error was below 3.4% for one pin loose, and below 29.3% for four pins loose, respectively. Measurement of stiffness data over time revealed a significant logarithmic increase between the third and seventh weeks, whereby the logarithmic rate of change among sheep was similar, but

  18. Reference Material for Seebeck Coefficients

    NASA Astrophysics Data System (ADS)

    Edler, F.; Lenz, E.; Haupt, S.

    2015-03-01

    This paper describes a measurement method and a measuring system to determine absolute Seebeck coefficients of thermoelectric bulk materials with the aim of establishing reference materials for Seebeck coefficients. Reference materials with known thermoelectric properties are essential to allow a reliable benchmarking of different thermoelectric materials for application in thermoelectric generators to convert thermal into electrical energy or vice versa. A temperature gradient (1 to 8) K is induced across the sample, and the resulting voltage is measured by using two differential Au/Pt thermocouples. On the basis of the known absolute Seebeck coefficients of Au and Pt, the unknown Seebeck coefficient of the sample is calculated. The measurements are performed in inert atmospheres and at low pressure (30 to 60) mbar in the temperature range between 300 K and 860 K. The measurement results of the Seebeck coefficients of metallic and semiconducting samples are presented. Achievable relative measurement uncertainties of the Seebeck coefficient are on the order of a few percent.

  19. A Treatise on Equivalent-Plate Stiffnesses for Stiffened Laminated-Composite Plates and Plate-Like Lattices

    NASA Technical Reports Server (NTRS)

    Nemeth, Michael P.

    2011-01-01

    A survey of studies conducted since 1914 on the use of equivalent-plate stiffnesses in modeling the overall, stiffness-critical response of stiffened plates and shells is presented. Two detailed, comprehensive derivations of first-approximation equivalent-plate stiffnesses are also presented that are based on the Reissner-Mindlin-type, first-order transverse-shear deformation theory for anisotropic plates. Equivalent-plate stiffness expressions, and a corresponding symbolic manipulation computer program, are also presented for several different stiffener configurations. These expressions are very general and exhibit the full range of anisotropies permitted by the Reissner-Mindlin-type, first-order transverse-shear deformation theory for anisotropic plates. The expressions presented in the present study were also compared with available, previously published results. For the most part, the previously published results are for special cases of the general expressions presented herein and are almost in complete agreement. Analysis is also presented that extends the use of the equivalent-plate stiffness expressions to sandwich plates.

  20. Arterial Stiffness in Children: Pediatric Measurement and Considerations

    PubMed Central

    Savant, Jonathan D.; Furth, Susan L.; Meyers, Kevin E.C.

    2014-01-01

    Background Arterial stiffness is a natural consequence of aging, accelerated in certain chronic conditions, and predictive of cardiovascular events in adults. Emerging research suggests the importance of arterial stiffness in pediatric populations. Methods There are different indices of arterial stiffness. The present manuscript focuses on carotid-femoral pulse wave velocity and pulse wave analysis, although other methodologies are discussed. Also reviewed are specific measurement considerations for pediatric populations and the literature describing arterial stiffness in children with certain chronic conditions (primary hypertension, obesity, diabetes, chronic kidney disease, hypercholesterolemia, genetic syndromes involving vasculopathy, and solid organ transplant recipients). Conclusions The measurement of arterial stiffness in children is feasible and, under controlled conditions, can give accurate information about the underlying state of the arteries. This potentially adds valuable information about the functionality of the cardiovascular system in children with a variety of chronic diseases well beyond that of the brachial artery blood pressure. PMID:26587447

  1. Determination of sedimentation coefficients for small peptides.

    PubMed Central

    Schuck, P; MacPhee, C E; Howlett, G J

    1998-01-01

    Direct fitting of sedimentation velocity data with numerical solutions of the Lamm equations has been exploited to obtain sedimentation coefficients for single solutes under conditions where solvent and solution plateaus are either not available or are transient. The calculated evolution was initialized with the first experimental scan and nonlinear regression was employed to obtain best-fit values for the sedimentation and diffusion coefficients. General properties of the Lamm equations as data analysis tools were examined. This method was applied to study a set of small peptides containing amphipathic heptad repeats with the general structure Ac-YS-(AKEAAKE)nGAR-NH2, n = 2, 3, or 4. Sedimentation velocity analysis indicated single sedimenting species with sedimentation coefficients (s(20,w) values) of 0.37, 0.45, and 0.52 S, respectively, in good agreement with sedimentation coefficients predicted by hydrodynamic theory. The described approach can be applied to synthetic boundary and conventional loading experiments, and can be extended to analyze sedimentation data for both large and small macromolecules in order to define shape, heterogeneity, and state of association. PMID:9449347

  2. Coefficient Alpha: A Reliability Coefficient for the 21st Century?

    ERIC Educational Resources Information Center

    Yang, Yanyun; Green, Samuel B.

    2011-01-01

    Coefficient alpha is almost universally applied to assess reliability of scales in psychology. We argue that researchers should consider alternatives to coefficient alpha. Our preference is for structural equation modeling (SEM) estimates of reliability because they are informative and allow for an empirical evaluation of the assumptions…

  3. Leg stiffness adjustment during hopping at different intensities and frequencies.

    PubMed

    Mrdakovic, Vladimir; Ilic, Dusko; Vulovic, Radun; Matic, Milan; Jankovic, Nenad; Filipovic, Nenad

    2014-01-01

    Understanding leg and joint stiffness adjustment during maximum hopping may provide important information for developing more effective training methods. It has been reported that ankle stiffness has major influence on stable spring-mass dynamics during submaximal hopping, and that knee stiffness is a major determinant for hopping performance during maximal hopping task. Furthermore, there are no reports on how the height of the previous hop could affect overall stiffness modulation of the subsequent maximum one. The purpose of the present study was to determine whether and how the jump height of the previous hop affects leg and joint stiffness for subsequent maximum hop. Ten participants completed trials in which they repeatedly hopped as high as possible (MX task) and trials in which they were instructed to perform several maximum hops with 3 preferred (optimal) height hops between each of them (P3MX task). Both hopping tasks were performed at 2.2 Hz hopping frequency and at the participant's preferred (freely chosen) frequency as well. By comparing results of those hopping tasks, we found that ankle stiffness at 2.2 Hz ( p = 0.041) and knee stiffness at preferred frequency ( p = 0.045) was significantly greater for MX versus P3MX tasks. Leg stiffness for 2.2 Hz hopping is greater than for the preferred frequency. Ankle stiffness is greater for 2.2 Hz than for preferred frequencies; opposite stands for knee stiffness. The results of this study suggest that preparatory hop height can be considered as an important factor for modulation of maximum hop. PMID:25308379

  4. Equivalent Dynamic Stiffness Mapping technique for identifying nonlinear structural elements from frequency response functions

    NASA Astrophysics Data System (ADS)

    Wang, X.; Zheng, G. T.

    2016-02-01

    A simple and general Equivalent Dynamic Stiffness Mapping technique is proposed for identifying the parameters or the mathematical model of a nonlinear structural element with steady-state primary harmonic frequency response functions (FRFs). The Equivalent Dynamic Stiffness is defined as the complex ratio between the internal force and the displacement response of unknown element. Obtained with the test data of responses' frequencies and amplitudes, the real and imaginary part of Equivalent Dynamic Stiffness are plotted as discrete points in a three dimensional space over the displacement amplitude and the frequency, which are called the real and the imaginary Equivalent Dynamic Stiffness map, respectively. These points will form a repeatable surface as the Equivalent Dynamic stiffness is only a function of the corresponding data as derived in the paper. The mathematical model of the unknown element can then be obtained by surface-fitting these points with special functions selected by priori knowledge of the nonlinear type or with ordinary polynomials if the type of nonlinearity is not pre-known. An important merit of this technique is its capability of dealing with strong nonlinearities owning complicated frequency response behaviors such as jumps and breaks in resonance curves. In addition, this technique could also greatly simplify the test procedure. Besides there is no need to pre-identify the underlying linear parameters, the method uses the measured data of excitation forces and responses without requiring a strict control of the excitation force during the test. The proposed technique is demonstrated and validated with four classical single-degree-of-freedom (SDOF) numerical examples and one experimental example. An application of this technique for identification of nonlinearity from multiple-degree-of-freedom (MDOF) systems is also illustrated.

  5. Inter-platform reproducibility of liver and spleen stiffness measured with MR Elastography

    PubMed Central

    Yasar, Temel Kaya; Wagner, Mathilde; Bane, Octavia; Besa, Cecilia; Babb, James S; Kannengiesser, Stephan; Fung, Maggie; Ehman, Richard L.; Taouli, Bachir

    2016-01-01

    Purpose To assess inter-platform reproducibility of liver stiffness (LS) and spleen stiffness (SS) measured with MR elastography (MRE) based on a 2D GRE sequence. Materials and Methods This prospective HIPAA-compliant and IRB-approved study involved 12 subjects (5 healthy volunteers and 7 patients with liver disease). A multi-slice 2D-GRE-based MRE sequence was performed using two systems from different vendors (3.0T GE and 1.5T Siemens) on the same day. Two independent observers measured LS and SS on confidence maps. Bland-Altman analysis (with coefficient of reproducibility, CR), coefficient of variability (CV) and intraclass correlation (ICC) were used to analyze inter-platform, intra- and inter-observer variability. Human data was validated using a gelatin-based phantom. Results There was excellent reproducibility of phantom stiffness measurement (CV 4.4%). Mean LS values were 3.44–3.48 kPa and 3.62–3.63 kPa, and mean SS values were 7.54–7.91 kPa and 8.40–8.85 kPa at 3.0T and 1.5T for observers 1 and 2, respectively. The mean CVs between platforms were 9.2%–11.5% and 13.1%–14.4% for LS and SS, respectively for observers 1 and 2. There was excellent inter-platform reproducibility (ICC >0.88 and CR <36.2%) for both LS and SS, and excellent intra- and inter-observer reproducibility (intra-observer: ICC >0.99, CV <2.1%, CR <6.6%; inter-observer: ICC >0.97, CV and CR <16%). Conclusion This study demonstrates that 2D-GRE MRE provides platform- and observer-independent LS and SS measurements. PMID:26469708

  6. Developing an effective arterial stiffness monitoring system using the spring constant method and photoplethysmography.

    PubMed

    Wei, Ching-Chuan

    2013-01-01

    This study aimed to develop a fast and effective arterial stiffness monitoring system for diabetic patients using the spring constant method and photoplethysmography (PPG). The experimental group comprised 70 patients (4 type 1 diabetes mellitus patients and 66 type 2 diabetes mellitus patients); 23 participants suffered from atherosclerosis. All were subjected to the measurements of both the carotid-femoral pulse wave velocity (cfPWV) and the spring constants evaluated using the PPG pulse as well as the radial pulse. The control group comprised 70 normal participants (39 men and 31 women) who did not have diabetes mellitus, with an age range of 40-84 years. All control group members were only subjected to the measurement by the spring constant method. For the experimental group, statistical analysis indicated a significantly high correlation between the spring constants computed using PPG and the radial pulse (p < 0.001, correlation coefficient =0.89). The result also showed a significant negative correlation between the cfPWV and the spring constant of PPG (p < 0.001, correlation coefficient = - 0.72); multivariate analysis similarly indicated a close relationship. In addition, we used Student's t test to examine the difference between the experimental and control groups for the spring constant of PPG. A P value less than 0.05 confirmed that the difference between the two groups was statistically significant. In the receiver operating characteristic curve, area under curve (=0.82) indicates a good discrimination, and a spring constant of PPG below 516 (g/s (2)) may imply a risk of arterial stiffness for diabetic patients. These findings imply that the spring constant of PPG could effectively identify normal versus abnormal characteristics of elasticity in normal and diabetic participants. As a result of some excellent characteristics in clinical monitoring, the spring constant computed using PPG shows the effectiveness and feasibility in the monitoring system of

  7. Classical and numerical approaches to determining V-section band clamp axial stiffness

    NASA Astrophysics Data System (ADS)

    Barrans, Simon M.; Khodabakhshi, Goodarz; Muller, Matthias

    2014-12-01

    V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the variety of V-band design and working conditions. In this paper models of the V-band are developed based on the classical theory of solid mechanics and the finite element method to study the behaviour of theV-bands under axial loading conditions. The good agreement between results from the developed FEA and the classical model support the suitability of the latter to modelV-band joints with diameters greater than 110mm under axial loading. The results from both models suggest that the axial stiffness for thisV-band cross section reaches a peak value for V-bands with radius of approximately 150 mmacross a wide range of coefficients of friction. Also, it is shown that the coefficient of friction and the wedge angle have a significant effect on the axial stiffness of V-bands.

  8. Sources of Variability in Musculo-Articular Stiffness Measurement

    PubMed Central

    Ditroilo, Massimiliano; Watsford, Mark; Murphy, Aron; De Vito, Giuseppe

    2013-01-01

    The assessment of musculo-articular stiffness (MAS) with the free-oscillation technique is a popular method with a variety of applications. This study examined the sources of variability (load applied and frequency of oscillation) when MAS is assessed. Over two testing occasions, 14 healthy men (27.7±5.2 yr, 1.82±0.04 m, 79.5±8.4 kg) were measured for isometric maximum voluntary contraction and MAS of the knee flexors using submaximal loads relative to the individual's maximum voluntary contraction (MAS%MVC) and a single absolute load (MASABS). As assessment load increased, MAS%MVC (coefficient of variation (CV)  =  8.1–12.1%; standard error of measurement (SEM)  =  51.6–98.8 Nm−1) and frequency (CV  =  4.8–7.0%; SEM  =  0.060–0.075 s−1) variability increased consequently. Further, similar levels of variability arising from load (CV  =  6.7%) and frequency (CV  =  4.8–7.0%) contributed to the overall MAS%MVC variability. The single absolute load condition yielded better reliability scores for MASABS (CV  =  6.5%; SEM  =  40.2 Nm−1) and frequency (CV  =  3.3%; SEM  =  0.039 s−1). Low and constant loads for MAS assessment, which are particularly relevant in the clinical setting, exhibited superior reliability compared to higher loads expressed as a percentage of maximum voluntary contraction, which are more suitable for sporting situations. Appropriate sample size and minimum detectable change can therefore be determined when prospective studies are carried out. PMID:23667662

  9. LSENS, a general chemical kinetics and sensitivity analysis code for gas-phase reactions: User's guide

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, Krishnan; Bittker, David A.

    1993-01-01

    A general chemical kinetics and sensitivity analysis code for complex, homogeneous, gas-phase reactions is described. The main features of the code, LSENS, are its flexibility, efficiency and convenience in treating many different chemical reaction models. The models include static system, steady, one-dimensional, inviscid flow, shock initiated reaction, and a perfectly stirred reactor. In addition, equilibrium computations can be performed for several assigned states. An implicit numerical integration method, which works efficiently for the extremes of very fast and very slow reaction, is used for solving the 'stiff' differential equation systems that arise in chemical kinetics. For static reactions, sensitivity coefficients of all dependent variables and their temporal derivatives with respect to the initial values of dependent variables and/or the rate coefficient parameters can be computed. This paper presents descriptions of the code and its usage, and includes several illustrative example problems.

  10. Factor Scores, Structure and Communality Coefficients: A Primer

    ERIC Educational Resources Information Center

    Odum, Mary

    2011-01-01

    (Purpose) The purpose of this paper is to present an easy-to-understand primer on three important concepts of factor analysis: Factor scores, structure coefficients, and communality coefficients. Given that statistical analyses are a part of a global general linear model (GLM), and utilize weights as an integral part of analyses (Thompson, 2006;…

  11. The application of automatic differentiation techniques for the prediction of rotor-dynamic coefficients of labyrinth seals

    NASA Astrophysics Data System (ADS)

    Fürst, Jiří

    2016-03-01

    The article describes the development of bulk-flow code for the prediction of rotor-dynamic coefficients of labyrinth seals. The code is based on the so-called single control volume approach by Childs and Scharrer [1] and the the forces are evaluated using the automatic differentiation technique. The resulting code is very simple and provides reasonable predictions of stiffness and damping coefficients at short computational time.

  12. Estimation of quasi-stiffness and propulsive work of the human ankle in the stance phase of walking.

    PubMed

    Shamaei, Kamran; Sawicki, Gregory S; Dollar, Aaron M

    2013-01-01

    Characterizing the quasi-stiffness and work of lower extremity joints is critical for evaluating human locomotion and designing assistive devices such as prostheses and orthoses intended to emulate the biological behavior of human legs. This work aims to establish statistical models that allow us to predict the ankle quasi-stiffness and net mechanical work for adults walking on level ground. During the stance phase of walking, the ankle joint propels the body through three distinctive phases of nearly constant stiffness known as the quasi-stiffness of each phase. Using a generic equation for the ankle moment obtained through an inverse dynamics analysis, we identify key independent parameters needed to predict ankle quasi-stiffness and propulsive work and also the functional form of each correlation. These parameters include gait speed, ankle excursion, and subject height and weight. Based on the identified form of the correlation and key variables, we applied linear regression on experimental walking data for 216 gait trials across 26 subjects (speeds from 0.75-2.63 m/s) to obtain statistical models of varying complexity. The most general forms of the statistical models include all the key parameters and have an R(2) of 75% to 81% in the prediction of the ankle quasi-stiffnesses and propulsive work. The most specific models include only subject height and weight and could predict the ankle quasi-stiffnesses and work for optimal walking speed with average error of 13% to 30%. We discuss how these models provide a useful framework and foundation for designing subject- and gait-specific prosthetic and exoskeletal devices designed to emulate biological ankle function during level ground walking.

  13. Estimation of Quasi-Stiffness and Propulsive Work of the Human Ankle in the Stance Phase of Walking

    PubMed Central

    Shamaei, Kamran; Sawicki, Gregory S.; Dollar, Aaron M.

    2013-01-01

    Characterizing the quasi-stiffness and work of lower extremity joints is critical for evaluating human locomotion and designing assistive devices such as prostheses and orthoses intended to emulate the biological behavior of human legs. This work aims to establish statistical models that allow us to predict the ankle quasi-stiffness and net mechanical work for adults walking on level ground. During the stance phase of walking, the ankle joint propels the body through three distinctive phases of nearly constant stiffness known as the quasi-stiffness of each phase. Using a generic equation for the ankle moment obtained through an inverse dynamics analysis, we identify key independent parameters needed to predict ankle quasi-stiffness and propulsive work and also the functional form of each correlation. These parameters include gait speed, ankle excursion, and subject height and weight. Based on the identified form of the correlation and key variables, we applied linear regression on experimental walking data for 216 gait trials across 26 subjects (speeds from 0.75–2.63 m/s) to obtain statistical models of varying complexity. The most general forms of the statistical models include all the key parameters and have an R2 of 75% to 81% in the prediction of the ankle quasi-stiffnesses and propulsive work. The most specific models include only subject height and weight and could predict the ankle quasi-stiffnesses and work for optimal walking speed with average error of 13% to 30%. We discuss how these models provide a useful framework and foundation for designing subject- and gait-specific prosthetic and exoskeletal devices designed to emulate biological ankle function during level ground walking. PMID:23555839

  14. Controlled Unusual Stiffness of Mechanical Metamaterials.

    PubMed

    Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul

    2016-02-03

    Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young's modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson's ratio of the constituent material changes the ratio while Young's modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications.

  15. Controlled Unusual Stiffness of Mechanical Metamaterials

    PubMed Central

    Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul

    2016-01-01

    Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young’s modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson’s ratio of the constituent material changes the ratio while Young’s modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications. PMID:26837466

  16. Stiffness nanotomography of human epithelial cancer cells

    NASA Astrophysics Data System (ADS)

    Staunton, Jack R.; Doss, Bryant L.; Gilbert, C. Michael; Kasas, Sandor; Ros, Robert

    2012-02-01

    The mechanical stiffness of individual cells is important in both cancer initiation and metastasis. We present atomic force microscopy (AFM) based nanoindentation experiments on various human mammary and esophagus cell lines covering the spectrum from normal immortalized cells to highly metastatic ones. The combination of an AFM with a confocal fluorescence lifetime imaging microscope (FLIM) in conjunction with the ability to move the sample and objective independently allow for precise alignment of AFM probe and laser focus with an accuracy down to a few nanometers. This enables us to correlate the mechanical properties with the point of indentation in the FLIM image. We are using force-volume measurements as well as force indentation curves on distinct points on the cells to compare the elastic moduli of the nuclei, nucleoli, and the cytoplasm, and how they vary within and between individual cells and cell lines. Further, a detailed analysis of the force-indentation curves allows study of the cells' mechanical properties at different indentation depths and to generate 3D elasticity maps.

  17. Controlled Unusual Stiffness of Mechanical Metamaterials

    NASA Astrophysics Data System (ADS)

    Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul

    2016-02-01

    Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young’s modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson’s ratio of the constituent material changes the ratio while Young’s modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications.

  18. Arterial stiffness and its clinical implications in women.

    PubMed

    Coutinho, Thais

    2014-07-01

    The burden of cardiovascular disease (CVD) in women is increasing, and CVD presently kills more North American women than men, highlighting the need for sex-specific research aimed at disentangling the complex interactions between sex, aging, and cardiovascular health. In the past decade, arterial stiffness has emerged as an independent predictor of adverse cardiovascular events and mortality, and its noninvasive, safe evaluation makes it an attractive tool for a snapshot assessment of cardiovascular health. An increasing number of reports have documented greater aortic stiffness in older women than men, which appears to have close relationships with blood pressure control, diastolic dysfunction, impaired ventricular coupling, and left ventricular remodelling in women. Thus, arterial stiffness is thought to play a role in the female predominance of several diseases such as isolated systolic hypertension, refractory hypertension, heart failure with preserved ejection fraction, and paradoxical low-flow, low-gradient, normal ejection fraction severe aortic stenosis. Furthermore, greater arterial stiffness is a common characteristic of women who develop hypertensive complications of pregnancy. Thus, better understanding sex differences in arterial stiffness and aging might provide valuable insights into CVD in women, and help identify novel risk stratification tools and therapeutic targets. To this end, the present review aims at describing sex differences in arterial stiffness, exploring the potential role of sex hormones and menopause on arterial aging, and highlighting the role of arterial stiffness in specific CVDs that preferentially affect women.

  19. Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption.

    PubMed

    Lampi, Marsha C; Faber, Courtney J; Huynh, John; Bordeleau, Francois; Zanotelli, Matthew R; Reinhart-King, Cynthia A

    2016-01-01

    Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors whose pleiotropic effects include disrupting small GTPase activity; therefore, we hypothesized the statin simvastatin could be used to attenuate RhoA activity and inhibit the deleterious effects of increased age-related matrix stiffness on endothelial barrier function. Using polyacrylamide gels with stiffnesses of 2.5, 5, and 10 kPa to mimic the physiological stiffness of young and aged arteries, endothelial cells were grown to confluence and treated with simvastatin. Our data indicate that RhoA and phosphorylated myosin light chain activity increase with matrix stiffness but are attenuated when treated with the statin. Increases in cell contractility, cell-cell junction size, and indirect measurements of intercellular tension that increase with matrix stiffness, and are correlated with matrix stiffness-dependent increases in monolayer permeability, also decrease with statin treatment. Furthermore, we report that simvastatin increases activated Rac1 levels that contribute to endothelial barrier enhancing cytoskeletal reorganization. Simvastatin, which is prescribed clinically due to its ability to lower cholesterol, alters the endothelial cell response to increased matrix stiffness to restore endothelial monolayer barrier function, and therefore, presents a possible therapeutic intervention to prevent atherogenesis initiated by age-related arterial stiffening.

  20. Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption

    PubMed Central

    Lampi, Marsha C.; Faber, Courtney J.; Huynh, John; Bordeleau, Francois; Zanotelli, Matthew R.; Reinhart-King, Cynthia A.

    2016-01-01

    Arterial stiffening accompanies both aging and atherosclerosis, and age-related stiffening of the arterial intima increases RhoA activity and cell contractility contributing to increased endothelium permeability. Notably, statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors whose pleiotropic effects include disrupting small GTPase activity; therefore, we hypothesized the statin simvastatin could be used to attenuate RhoA activity and inhibit the deleterious effects of increased age-related matrix stiffness on endothelial barrier function. Using polyacrylamide gels with stiffnesses of 2.5, 5, and 10 kPa to mimic the physiological stiffness of young and aged arteries, endothelial cells were grown to confluence and treated with simvastatin. Our data indicate that RhoA and phosphorylated myosin light chain activity increase with matrix stiffness but are attenuated when treated with the statin. Increases in cell contractility, cell-cell junction size, and indirect measurements of intercellular tension that increase with matrix stiffness, and are correlated with matrix stiffness-dependent increases in monolayer permeability, also decrease with statin treatment. Furthermore, we report that simvastatin increases activated Rac1 levels that contribute to endothelial barrier enhancing cytoskeletal reorganization. Simvastatin, which is prescribed clinically due to its ability to lower cholesterol, alters the endothelial cell response to increased matrix stiffness to restore endothelial monolayer barrier function, and therefore, presents a possible therapeutic intervention to prevent atherogenesis initiated by age-related arterial stiffening. PMID:26761203

  1. Substrate stiffness regulates extracellular matrix deposition by alveolar epithelial cells

    PubMed Central

    Eisenberg, Jessica L; Safi, Asmahan; Wei, Xiaoding; Espinosa, Horacio D; Budinger, GR Scott; Takawira, Desire; Hopkinson, Susan B; Jones, Jonathan CR

    2012-01-01

    Aim The aim of the study was to address whether a stiff substrate, a model for pulmonary fibrosis, is responsible for inducing changes in the phenotype of alveolar epithelial cells (AEC) in the lung, including their deposition and organization of extracellular matrix (ECM) proteins. Methods Freshly isolated lung AEC from male Sprague Dawley rats were seeded onto polyacrylamide gel substrates of varying stiffness and analyzed for expression and organization of adhesion, cytoskeletal, differentiation, and ECM components by Western immunoblotting and confocal immunofluorescence microscopy. Results We observed that substrate stiffness influences cell morphology and the organization of focal adhesions and the actin cytoskeleton. Surprisingly, however, we found that substrate stiffness has no influence on the differentiation of type II into type I AEC, nor does increased substrate stiffness lead to an epithelial–mesenchymal transition. In contrast, our data indicate that substrate stiffness regulates the expression of the α3 laminin subunit by AEC and the organization of both fibronectin and laminin in their ECM. Conclusions An increase in substrate stiffness leads to enhanced laminin and fibronectin assembly into fibrils, which likely contributes to the disease phenotype in the fibrotic lung. PMID:23204878

  2. Charts relating the compressive buckling stress of longitudinally supported plates to the effective deflectional and rotational stiffness of the supports

    NASA Technical Reports Server (NTRS)

    Anderson, Roger A; Semonian, Joseph W

    1954-01-01

    A stability analysis is made of a long flat rectangular plate subjected to a uniform longitudinal compressive stress and supported along its longitudinal edges and along one or more longitudinal lines by elastic line supports. The elastic supports possess deflectional and rotational stiffness. Such configuration is an idealization of the compression cover skin and internal structure of a wing and tail surfaces. The results of the analysis are presented in the form of charts in which the buckling-stress coefficient is plotted against the buckle length of the plate for a wide range of support stiffnesses. The charts make possible the determination of the compressive buckling stress of plates supported by members whose stiffness may or may not be defined by elementary beam bending and twisting theory but yet whose effective restraint is amenable to evaluation. The deflectional and rotational stiffness provided by longitudinal stiffeners and full-depth webs is discussed and numerical examples are given to illustrate the application of the charts to the design of wing structures.

  3. Use of Guided Acoustic Waves to Assess the Effects of Thermal-Mechanical Cycling on Composite Stiffness

    NASA Technical Reports Server (NTRS)

    Seale, Michael D.; Madaras, Eric I.

    2000-01-01

    The introduction of new, advanced composite materials into aviation systems requires it thorough understanding of the long-term effects of combined thermal and mechanical loading. As part of a study to evaluate the effects of thermal-mechanical cycling, it guided acoustic (Lamb) wave measurement system was used to measure the bending and out-of-plane stiffness coefficients of composite laminates undergoing thermal-mechanical loading. The system uses a pulse/receive technique that excites an antisymmetric Lamb mode and measures the time-of-flight over a wide frequency range. Given the material density and plate thickness, the bending and out-of-plane shear stiffnesses are calculated from a reconstruction of the velocity dispersion curve. A series of 16 and 32-ply composite laminates were subjected to it thermal-mechanical loading profile in load frames equipped with special environmental chambers. The composite systems studied were it graphite fiber reinforced amorphous thermoplastic polyimide and it graphite fiber reinforced bismaleimide thermoset. The samples were exposed to both high and low temperature extremes its well as high and low strain profiles. The bending and out-of-plane stiffnesses for composite sample that have undergone over 6,000 cycles of thermal-mechanical loading are reported. The Lamb wave generated elastic stiffness results have shown decreases of up to 20% at 4,936 loading cycles for the graphite/thermoplastic samples and up to 64% at 4,706 loading cycles for the graphite/thermoset samples.

  4. Impact of blood pressure perturbations on arterial stiffness.

    PubMed

    Lim, Jisok; Pearman, Miriam E; Park, Wonil; Alkatan, Mohammed; Machin, Daniel R; Tanaka, Hirofumi

    2015-12-15

    Although the associations between chronic levels of arterial stiffness and blood pressure (BP) have been fairly well studied, it is not clear whether and how much arterial stiffness is influenced by acute perturbations in BP. The primary aim of this study was to determine magnitudes of BP dependence of various measures of arterial stiffness during acute BP perturbation maneuvers. Fifty apparently healthy subjects, including 25 young (20-40 yr) and 25 older adults (60-80 yr), were studied. A variety of BP perturbations, including head-up tilt, head-down tilt, mental stress, isometric handgrip exercise, and cold pressor test, were used to encompass BP changes induced by physical, mental, and/or mechanical stimuli. When each index of arterial stiffness was plotted with mean BP, all arterial stiffness indices, including cardio-ankle vascular index or CAVI (r = 0.50), carotid-femoral pulse wave velocity or cfPWV (r = 0.51), brachial-ankle pulse wave velocity or baPWV (r = 0.61), arterial compliance (r = -0.42), elastic modulus (r = 0.52), arterial distensibility (r = -0.32), β-stiffness index (r = 0.19), and Young's modulus (r = 0.35) were related to mean BP (all P < 0.01). Changes in CAVI, cfPWV, baPWV, and elastic modulus were significantly associated with changes in mean BP in the pooled conditions, while changes in arterial compliance, arterial distensibility, β-stiffness index, and Young's modulus were not. In conclusion, this study demonstrated that BP changes in response to various forms of pressor stimuli were associated with the corresponding changes in arterial stiffness indices and that the strengths of associations with BP varied widely depending on what arterial stiffness indices were examined. PMID:26468262

  5. Impact of blood pressure perturbations on arterial stiffness.

    PubMed

    Lim, Jisok; Pearman, Miriam E; Park, Wonil; Alkatan, Mohammed; Machin, Daniel R; Tanaka, Hirofumi

    2015-12-15

    Although the associations between chronic levels of arterial stiffness and blood pressure (BP) have been fairly well studied, it is not clear whether and how much arterial stiffness is influenced by acute perturbations in BP. The primary aim of this study was to determine magnitudes of BP dependence of various measures of arterial stiffness during acute BP perturbation maneuvers. Fifty apparently healthy subjects, including 25 young (20-40 yr) and 25 older adults (60-80 yr), were studied. A variety of BP perturbations, including head-up tilt, head-down tilt, mental stress, isometric handgrip exercise, and cold pressor test, were used to encompass BP changes induced by physical, mental, and/or mechanical stimuli. When each index of arterial stiffness was plotted with mean BP, all arterial stiffness indices, including cardio-ankle vascular index or CAVI (r = 0.50), carotid-femoral pulse wave velocity or cfPWV (r = 0.51), brachial-ankle pulse wave velocity or baPWV (r = 0.61), arterial compliance (r = -0.42), elastic modulus (r = 0.52), arterial distensibility (r = -0.32), β-stiffness index (r = 0.19), and Young's modulus (r = 0.35) were related to mean BP (all P < 0.01). Changes in CAVI, cfPWV, baPWV, and elastic modulus were significantly associated with changes in mean BP in the pooled conditions, while changes in arterial compliance, arterial distensibility, β-stiffness index, and Young's modulus were not. In conclusion, this study demonstrated that BP changes in response to various forms of pressor stimuli were associated with the corresponding changes in arterial stiffness indices and that the strengths of associations with BP varied widely depending on what arterial stiffness indices were examined.

  6. Leg stiffness and joint stiffness while running to and jumping over an obstacle.

    PubMed

    Mauroy, G; Schepens, B; Willems, P A

    2014-01-22

    During running, muscles of the lower limb act like a linear spring bouncing on the ground. When approaching an obstacle, the overall stiffness of this leg-spring system (k(leg)) is modified during the two steps preceding the jump to enhance the movement of the center of mass of the body while leaping the obstacle. The aim of the present study is to understand how k(leg) is modified during the running steps preceding the jump. Since k(leg) depends on the joint torsional stiffness and on the leg geometry, we analyzed the changes in these two parameters in eight subjects approaching and leaping a 0.65 m-high barrier at 15 km h(-1). Ground reaction force (F) was measured during 5-6 steps preceding the obstacle using force platform and the lower limb movements were recorded by camera. From these data, the net muscular moment (M(j)), the angular displacement (θ(j)) and the lever arm of F were evaluated at the hip, knee and ankle. At the level of the hip, the M(j)-θ(j) relation shows that muscles are not acting like torsional springs. At the level of the knee and ankle, the M(j)-θ(j) relation shows that muscles are acting like torsional springs: as compared to steady-state running, the torsional stiffness k(j) decreases from ~1/3 two contacts before the obstacle, and increases from ~2/3 during the last contact. These modifications in k(j) reflect in changes in the magnitude of F but also to changes in the leg geometry, i.e. in the lever arms of F.

  7. Relationship Between Determinants of Arterial Stiffness Assessed by Diastolic and Suprasystolic Pulse Oscillometry

    PubMed Central

    Teren, Andrej; Beutner, Frank; Wirkner, Kerstin; Löffler, Markus; Scholz, Markus

    2016-01-01

    Abstract Pulse wave velocity (PWV) and augmentation index (AI) are independent predictors of cardiovascular health. However, the comparability of multiple oscillometric modalities currently available for their assessment was not studied in detail. In the present study, we aimed to evaluate the relationship between indices of arterial stiffness assessed by diastolic and suprasystolic oscillometry. In total, 56 volunteers from the general population (23 males; median age 70 years [interquartile range: 65–72 years]) were recruited into observational feasibility study to evaluate the carotid-femoral/aortic PWV (cf/aoPWV), brachial-ankle PWV (baPWV), and AI assessed by 2 devices: Vicorder (VI) applying diastolic, right-sided oscillometry for the determination of all 3 indices, and Vascular explorer (VE) implementing single-point, suprasystolic brachial oscillometry (SSBO) pulse wave analysis for the assessment of cfPWV and AI. Within- and between-device correlations of measured parameters were analyzed. Furthermore, agreement of repeated measurements, intra- and inter-observer concordances were determined and compared for both devices. In VI, both baPWV and cfPWV inter-correlated well and showed good level of agreement with bilateral baPWV measured by VE (baPWV[VI]–baPWV[VE]R: overall concordance correlation coefficient [OCCC] = 0.484, mean difference = 1.94 m/s; cfPWV[VI]–baPWV[VE]R: OCCC = 0.493, mean difference = 1.0 m/s). In contrast, SSBO-derived aortic PWA (cf/aoPWA[VE]) displayed only weak correlation with cfPWV(VI) (r = 0.196; P = 0.04) and ipsilateral baPWV (cf/aoPWV[VE]R–baPWV[VE]R: r = 0.166; P = 0.08). cf/aoPWA(VE) correlated strongly with AI(VE) (right-sided: r = 0.725, P < 0.001). AI exhibited marginal between-device agreement (right-sided: OCCC = 0.298, mean difference: 6.12%). All considered parameters showed good-to-excellent repeatability giving OCCC > 0.9 for 2-point-PWV modes and right-sided AI

  8. Cytoplasmic hydrogen ion diffusion coefficient.

    PubMed Central

    al-Baldawi, N F; Abercrombie, R F

    1992-01-01

    The apparent cytoplasmic proton diffusion coefficient was measured using pH electrodes and samples of cytoplasm extracted from the giant neuron of a marine invertebrate. By suddenly changing the pH at one surface of the sample and recording the relaxation of pH within the sample, an apparent diffusion coefficient of 1.4 +/- 0.5 x 10(-6) cm2/s (N = 7) was measured in the acidic or neutral range of pH (6.0-7.2). This value is approximately 5x lower than the diffusion coefficient of the mobile pH buffers (approximately 8 x 10(-6) cm2/s) and approximately 68x lower than the diffusion coefficient of the hydronium ion (93 x 10(-6) cm2/s). A mobile pH buffer (approximately 15% of the buffering power) and an immobile buffer (approximately 85% of the buffering power) could quantitatively account for the results at acidic or neutral pH. At alkaline pH (8.2-8.6), the apparent proton diffusion coefficient increased to 4.1 +/- 0.8 x 10(-6) cm2/s (N = 7). This larger diffusion coefficient at alkaline pH could be explained quantitatively by the enhanced buffering power of the mobile amino acids. Under the conditions of these experiments, it is unlikely that hydroxide movement influences the apparent hydrogen ion diffusion coefficient. PMID:1617134

  9. Arterial stiffness in kidney transplantation: a single center case-control study comparing belatacept versus calcineurin inhibitor immunosuppressive based regimen.

    PubMed

    Melilli, Edoardo; Bestard-Matamoros, Oriol; Manonelles-Montero, Anna; Sala-Bassa, Neus; Mast, Richard; Grinyó-Boira, Josep M; Cruzado, Josep M

    2015-01-01

    Arterial stiffness is nowadays a well-accepted predictor of cardiovascular mortality in general population; as well as in kidney transplant recipient population. The femoral-carotid pulse wave velocity (cf-PWV) is the widest used method to assess the arterial stiffness. The aim of this study was to test whether CNI-free immunosuppression based on belatacept was associated with lower cf-PWV, as a surrogate marker of arterial stiffness, than CNI. This was a retrospective case-control study. We included all the cases treated with belatacept as a maintenance immunosuppression in our center (n=20). An appropriate control group of patients (n=20) treated with CNI was selected to achieve match for key factors associated with arterial stiffness. After a follow-up of 5 years after transplantation, the Belatacept group had a reduced prevalence of patients with a cf-PWV higher than 8.1m/s (50% in BLC vs. 25% in CNI, p=0.08). At multivariate logistic regression analysis, the risk of high cf-PWV was correlated with age (OR 1.24; p<0.03) and renal resistive index (OR 1.25; p<0.05). Belatacept treatment was associated with a significant reduction in risk of cf-PWV (OR 0.008; P=0.045). Belatacept-based maintenance immunosuppression could improve kidney transplant recipient’s survival by reducing cardiovascular events related to stiffness. PMID:25611834

  10. Bitplane Image Coding With Parallel Coefficient Processing.

    PubMed

    Auli-Llinas, Francesc; Enfedaque, Pablo; Moure, Juan C; Sanchez, Victor

    2016-01-01

    Image coding systems have been traditionally tailored for multiple instruction, multiple data (MIMD) computing. In general, they partition the (transformed) image in codeblocks that can be coded in the cores of MIMD-based processors. Each core executes a sequential flow of instructions to process the coefficients in the codeblock, independently and asynchronously from the others cores. Bitplane coding is a common strategy to code such data. Most of its mechanisms require sequential processing of the coefficients. The last years have seen the upraising of processing accelerators with enhanced computational performance and power efficiency whose architecture is mainly based on the single instruction, multiple data (SIMD) principle. SIMD computing refers to the execution of the same instruction to multiple data in a lockstep synchronous way. Unfortunately, current bitplane coding strategies cannot fully profit from such processors due to inherently sequential coding task. This paper presents bitplane image coding with parallel coefficient (BPC-PaCo) processing, a coding method that can process many coefficients within a codeblock in parallel and synchronously. To this end, the scanning order, the context formation, the probability model, and the arithmetic coder of the coding engine have been re-formulated. The experimental results suggest that the penalization in coding performance of BPC-PaCo with respect to the traditional strategies is almost negligible.

  11. Recursive Construction of Operator Product Expansion Coefficients

    NASA Astrophysics Data System (ADS)

    Holland, Jan; Hollands, Stefan

    2015-06-01

    We derive a novel formula for the derivative of operator product expansion (OPE) coefficients with respect to a coupling constant. The formula involves just the OPE coefficients themselves but no further input, and is in this sense self-consistent. Furthermore, unlike other formal identities of this general nature in quantum field theory (such as the formal expression for the Lagrangian perturbation of a correlation function), our formula requires no further UV-renormalization, i.e., it is completely well-defined from the start. This feature is a result of a cancelation of UV- and IR-divergences between various terms in our identity. Our proof, and an analysis of the features of the identity, is given for the example of massive, Euclidean theory in 4 dimensional Euclidean space. It relies on the renormalization group flow equation method and is valid to arbitrary, but finite orders in perturbation theory. The final formula, however, makes neither explicit reference to the renormalization group flow, nor to perturbation theory, and we conjecture that it also holds non-perturbatively. Our identity can be applied constructively because it gives a novel recursive algorithm for the computation of OPE coefficients to arbitrary (finite) perturbation order in terms of the zeroth order coefficients corresponding to the underlying free field theory, which in turn are trivial to obtain. We briefly illustrate the relation of this method to more standard methods for computing the OPE in some simple examples.

  12. Modulating polymer chemistry to enhance non-viral gene delivery inside hydrogels with tunable matrix stiffness.

    PubMed

    Keeney, Michael; Onyiah, Sheila; Zhang, Zhe; Tong, Xinming; Han, Li-Hsin; Yang, Fan

    2013-12-01

    Non-viral gene delivery holds great promise for promoting tissue regeneration, and offers a potentially safer alternative than viral vectors. Great progress has been made to develop biodegradable polymeric vectors for non-viral gene delivery in 2D culture, which generally involves isolating and modifying cells in vitro, followed by subsequent transplantation in vivo. Scaffold-mediated gene delivery may eliminate the need for the multiple-step process in vitro, and allows sustained release of nucleic acids in situ. Hydrogels are widely used tissue engineering scaffolds given their tissue-like water content, injectability and tunable biochemical and biophysical properties. However, previous attempts on developing hydrogel-mediated non-viral gene delivery have generally resulted in low levels of transgene expression inside 3D hydrogels, and increasing hydrogel stiffness further decreased such transfection efficiency. Here we report the development of biodegradable polymeric vectors that led to efficient gene delivery inside poly(ethylene glycol) (PEG)-based hydrogels with tunable matrix stiffness. Photocrosslinkable gelatin was maintained constant in the hydrogel network to allow cell adhesion. We identified a lead biodegradable polymeric vector, E6, which resulted in increased polyplex stability, DNA protection and achieved sustained high levels of transgene expression inside 3D PEG-DMA hydrogels for at least 12 days. Furthermore, we demonstrated that E6-based polyplexes allowed efficient gene delivery inside hydrogels with tunable stiffness ranging from 2 to 175 kPa, with the peak transfection efficiency observed in hydrogels with intermediate stiffness (28 kPa). The reported hydrogel-mediated gene delivery platform using biodegradable polyplexes may serve as a local depot for sustained transgene expression in situ to enhance tissue engineering across broad tissue types.

  13. Modeling, Modal Properties, and Mesh Stiffness Variation Instabilities of Planetary Gears

    NASA Technical Reports Server (NTRS)

    Parker, Robert G.; Lin, Jian; Krantz, Timothy L. (Technical Monitor)

    2001-01-01

    Planetary gear noise and vibration are primary concerns in their applications in helicopters, automobiles, aircraft engines, heavy machinery and marine vehicles. Dynamic analysis is essential to the noise and vibration reduction. This work analytically investigates some critical issues and advances the understanding of planetary gear dynamics. A lumped-parameter model is built for the dynamic analysis of general planetary gears. The unique properties of the natural frequency spectra and vibration modes are rigorously characterized. These special structures apply for general planetary gears with cyclic symmetry and, in practically important case, systems with diametrically opposed planets. The special vibration properties are useful for subsequent research. Taking advantage of the derived modal properties, the natural frequency and vibration mode sensitivities to design parameters are investigated. The key parameters include mesh stiffnesses, support/bearing stiffnesses, component masses, moments of inertia, and operating speed. The eigen-sensitivities are expressed in simple, closed-form formulae associated with modal strain and kinetic energies. As disorders (e.g., mesh stiffness variation. manufacturing and assembling errors) disturb the cyclic symmetry of planetary gears, their effects on the free vibration properties are quantitatively examined. Well-defined veering rules are derived to identify dramatic changes of natural frequencies and vibration modes under parameter variations. The knowledge of free vibration properties, eigen-sensitivities, and veering rules provide important information to effectively tune the natural frequencies and optimize structural design to minimize noise and vibration. Parametric instabilities excited by mesh stiffness variations are analytically studied for multi-mesh gear systems. The discrepancies of previous studies on parametric instability of two-stage gear chains are clarified using perturbation and numerical methods. The

  14. Micropipette aspiration of substrate-attached cells to estimate cell stiffness.

    PubMed

    Oh, Myung-Jin; Kuhr, Frank; Byfield, Fitzroy; Levitan, Irena

    2012-09-27

    Growing number of studies show that biomechanical properties of individual cells play major roles in multiple cellular functions, including cell proliferation, differentiation, migration and cell-cell interactions. The two key parameters of cellular biomechanics are cellular deformability or stiffness and the ability of the cells to contract and generate force. Here we describe a quick and simple method to estimate cell stiffness by measuring the degree of membrane deformation in response to negative pressure applied by a glass micropipette to the cell surface, a technique that is called Micropipette Aspiration or Microaspiration. Microaspiration is performed by pulling a glass capillary to create a micropipette with a very small tip (2-50 μm diameter depending on the size of a cell or a tissue sample), which is then connected to a pneumatic pressure transducer and brought to a close vicinity of a cell under a microscope. When the tip of the pipette touches a cell, a step of negative pressure is applied to the pipette by the pneumatic pressure transducer generating well-defined pressure on the cell membrane. In response to pressure, the membrane is aspirated into the pipette and progressive membrane deformation or "membrane projection" into the pipette is measured as a function of time. The basic principle of this experimental approach is that the degree of membrane deformation in response to a defined mechanical force is a function of membrane stiffness. The stiffer the membrane is, the slower the rate of membrane deformation and the shorter the steady-state aspiration length. The technique can be performed on isolated cells, both in suspension and substrate-attached, large organelles, and liposomes. Analysis is performed by comparing maximal membrane deformations achieved under a given pressure for different cell populations or experimental conditions. A "stiffness coefficient" is estimated by plotting the aspirated length of membrane deformation as a function

  15. Effective Spring Stiffness for a Planar Periodic Array of Collinear Cracks at an Interface between Two Dissimilar Isotropic Materials

    PubMed Central

    Lekesiz, Huseyin; Katsube, Noriko; Rokhlin, Stanislav I.; Seghi, Robert R.

    2011-01-01

    Explicit analytical expressions are obtained for the longitudinal and transverse effective spring stiffnesses of a planar periodic array of collinear cracks at the interface between two dissimilar isotropic materials; they are shown to be identical in a general case of elastic dissimilarity (the well-known open interface crack model is employed for the solution). Since the interfacial spring stiffness can be experimentally determined from ultrasound reflection and transmission analysis, the proposed expressions can be useful in estimating the percentage of disbond area between two dissimilar materials, which is directly related to the residual strength of the interface. The effects of elastic dissimilarity, crack density and crack interaction on the effective spring stiffness are clearly represented in the solution. It is shown that in general the crack interaction weakly depends on material dissimilarity and, for most practical cases, the crack interaction is nearly the same as that for crack arrays between identical solids. This allows approximate factorization of the effective spring stiffness for an array of cracks between dissimilar materials in terms of an elastic dissimilarity factor and two factors obtained for cracks in a homogeneous material: the effective spring stiffness for non-interacting (independent) cracks and the crack interaction factor. In order to avoid the effect of the crack surface interpenetration zones on the effective spring stiffness, the range of the tensile to transverse load ratios is obtained under the assumption of small-scale contact conditions. Since real cracks are often slightly open (due to prior loading history and plastic deformation), it is demonstrated that for ultrasound applications the results obtained are valid for most practical cases of small interfacial cracks as long as the mid-crack opening normalized by the crack length is at least in the order of 10−5. PMID:23710104

  16. Quaternion representations of stiffness and momentum of the forces, acting in vibration isolating systems with stiffness compensators

    NASA Astrophysics Data System (ADS)

    Gurova, E. G.

    2016-04-01

    This research is devoted to development of the spatial vibration isolation devices. The description of the vibration isolation systems has been presented through quaternions of the forces, momentums, and stiffness. The considered method allows taking into account the stochastic vibrations and describes it with the help of the hypercomplex numbers. The theory suggests the development of the vibration isolation devices, which have traction characteristics with zero stiffness area. To obtain such area in traction characteristic, a spatial vibration isolator is presented as a resilient element and the stiffness compensator, which is connected in parallel with it.

  17. Stiff DAE integrator with sensitivity analysis capabilities

    2007-11-26

    IDAS is a general purpose (serial and parallel) solver for differential equation (ODE) systems with senstivity analysis capabilities. It provides both forward and adjoint sensitivity analysis options.

  18. Stiffness of Carpentry Connections - Numerical Modelling vs. Experimental Test

    NASA Astrophysics Data System (ADS)

    Kekeliak, Miloš; Gocál, Jozef; Vičan, Josef

    2015-12-01

    In this paper, numerical modelling of the traditional carpentry connection with mortise and tenon is presented. Numerical modelling is focused on its stiffness and the results are compared to results of experimental tests carried out by (Feio, 2005) [6]. To consider soft behaviour of wood in carpentry connections, which are related to its surface roughness and geometrical accuracy of the contact surfaces, the characteristics of the normal contact stiffness, determined experimentally, are introduced in the numerical model. Parametric study by means of numerical modelling with regard to the sensitivity of connection stiffness to contact stiffness is presented. Based on the study results, in conclusion there are presented relevant differences between the results of numerical modelling and experimental tests (Feio, 2005) [6].

  19. Molecular Cues Guiding Matrix Stiffness in Liver Fibrosis

    PubMed Central

    Saneyasu, Takaoki; Akhtar, Riaz

    2016-01-01

    Tissue and matrix stiffness affect cell properties during morphogenesis, cell growth, differentiation, and migration and are altered in the tissue remodeling following injury and the pathological progression. However, detailed molecular mechanisms underlying alterations of stiffness in vivo are still poorly understood. Recent engineering technologies have developed powerful techniques to characterize the mechanical properties of cell and matrix at nanoscale levels. Extracellular matrix (ECM) influences mechanical tension and activation of pathogenic signaling during the development of chronic fibrotic diseases. In this short review, we will focus on the present knowledge of the mechanisms of how ECM stiffness is regulated during the development of liver fibrosis and the molecules involved in ECM stiffness as a potential therapeutic target for liver fibrosis. PMID:27800489

  20. Improved Equivalent Linearization Implementations Using Nonlinear Stiffness Evaluation

    NASA Technical Reports Server (NTRS)

    Rizzi, Stephen A.; Muravyov, Alexander A.

    2001-01-01

    This report documents two new implementations of equivalent linearization for solving geometrically nonlinear random vibration problems of complicated structures. The implementations are given the acronym ELSTEP, for "Equivalent Linearization using a STiffness Evaluation Procedure." Both implementations of ELSTEP are fundamentally the same in that they use a novel nonlinear stiffness evaluation procedure to numerically compute otherwise inaccessible nonlinear stiffness terms from commercial finite element programs. The commercial finite element program MSC/NASTRAN (NASTRAN) was chosen as the core of ELSTEP. The FORTRAN implementation calculates the nonlinear stiffness terms and performs the equivalent linearization analysis outside of NASTRAN. The Direct Matrix Abstraction Program (DMAP) implementation performs these operations within NASTRAN. Both provide nearly identical results. Within each implementation, two error minimization approaches for the equivalent linearization procedure are available - force and strain energy error minimization. Sample results for a simply supported rectangular plate are included to illustrate the analysis procedure.

  1. Portal frame inertia and stiffness matrices by substructure synthesis

    NASA Astrophysics Data System (ADS)

    Morales, C. A.

    2005-05-01

    Generic expressions of mass and stiffness matrices of the portal frame are presented. These are derived by means of the substructure synthesis method. This method is exceptionally characterised by low-order eigenvalue problems and highly accurate eigensolutions.

  2. Arterial stiffness estimation based photoplethysmographic pulse wave analysis

    NASA Astrophysics Data System (ADS)

    Huotari, Matti; Maatta, Kari; Kostamovaara, Juha

    2010-11-01

    Arterial stiffness is one of the indices of vascular healthiness. It is based on pulse wave analysis. In the case we decompose the pulse waveform for the estimation and determination of arterial elasticity. Firstly, optically measured with photoplethysmograph and then investigating means by four lognormal pulse waveforms for which we can find very good fit between the original and summed decomposed pulse wave. Several studies have demonstrated that these kinds of measures predict cardiovascular events. While dynamic factors, e.g., arterial stiffness, depend on fixed structural features of the vascular wall. Arterial stiffness is estimated based on pulse wave decomposition analysis in the radial and tibial arteries. Elucidation of the precise relationship between endothelial function and vascular stiffness awaits still further study.

  3. Operator-Based Preconditioning of Stiff Hyperbolic Systems

    SciTech Connect

    Reynolds, Daniel R.; Samtaney, Ravi; Woodward, Carol S.

    2009-02-09

    We introduce an operator-based scheme for preconditioning stiff components encoun- tered in implicit methods for hyperbolic systems of partial differential equations posed on regular grids. The method is based on a directional splitting of the implicit operator, followed by a char- acteristic decomposition of the resulting directional parts. This approach allows for solution to any number of characteristic components, from the entire system to only the fastest, stiffness-inducing waves. We apply the preconditioning method to stiff hyperbolic systems arising in magnetohydro- dynamics and gas dynamics. We then present numerical results showing that this preconditioning scheme works well on problems where the underlying stiffness results from the interaction of fast transient waves with slowly-evolving dynamics, scales well to large problem sizes and numbers of processors, and allows for additional customization based on the specific problems under study.

  4. Arterial Stiffness and Renal Replacement Therapy: A Controversial Topic

    PubMed Central

    Fischer, Edmundo Cabrera; Zócalo, Yanina; Galli, Cintia; Bia, Daniel

    2015-01-01

    The increase of arterial stiffness has been to have a significant impact on predicting mortality in end-stage renal disease patients. Pulse wave velocity (PWV) is a noninvasive, reliable parameter of regional arterial stiffness that integrates the vascular geometry and arterial wall intrinsic elasticity and is capable of predicting cardiovascular mortality in this patient population. Nevertheless, reports on PWV in dialyzed patients are contradictory and sometimes inconsistent: some reports claim the arterial wall stiffness increases (i.e., PWV increase), others claim that it is reduced, and some even state that it augments in the aorta while it simultaneously decreases in the brachial artery pathway. The purpose of this study was to analyze the literature in which longitudinal or transversal studies were performed in hemodialysis and/or peritoneal dialysis patients, in order to characterize arterial stiffness and the responsiveness to renal replacement therapy. PMID:26064684

  5. [Impact of aortic stiffness on central hemodynamics and cardiovascular system].

    PubMed

    Bulas, J; Potočárová, M; Filková, M; Simková, A; Murín, J

    2013-06-01

    Arterial stiffness increases as a result of degenerative processes accelerated by aging and many risk factors, namely arterial hypertension. Basic clinical examination reveals increased pulse pressure as its hemodynamic manifestation. The most serious consequence of increased vascular stiffness, which cannot be revealed by clinical examination, is a change of central hemodynamics leading to increased load of left ventricle, left ventricular hypertrophy, diastolic dysfunction and to overall increase of cardiovascular risk. This review aimed to point at some patophysiological mechanisms taking part in the development of vascular stiffness, vascular remodeling and hemodynamic consequences of these changes. This work also gives an overview of noninvasive examination methods and their characteristics enabling to evaluate the local, regional and systemic arterial stiffness and central pulse wave analysis and their meaning for central hemodynamics and heart workload. PMID:23808736

  6. Stiffness Corrections for the Vibration Frequency of a Stretched Wire

    ERIC Educational Resources Information Center

    Hornung, H. G.; Durie, M. J.

    1977-01-01

    Discusses the need of introducing corrections due to wire stiffness arising from end constraints and wire axis distribution curvature in the measurement of ac electrical frequency by exciting transverse standing waves in a stretched steel wire. (SL)

  7. Intrinsic, reflex and voluntary contributions to task-dependent joint stiffness.

    PubMed

    Ludvig, Daniel; Kearney, Robert E

    2010-01-01

    Dynamic joint stiffness defines the dynamic relationship between the position of the joint and the torque acting about it. Joint stiffness consists of two components: intrinsic and reflex stiffness. Previous work from our lab has shown that subjects can alter their reflex stiffness voluntarily and independently of intrinsic stiffness. Numerous studies have investigated whether reflex stiffness is altered in a task-dependent fashion; however the results of these studies are inconclusive. We designed an experimental paradigm where subjects were faced with 3 tasks: one task where joint stiffness aided subjects, a second where joint stiffness hindered the subjects and a third where joint stiffness had no effect. We found that subjects did not alter their joint stiffness to perform the different tasks. Rather, they performed the tasks by voluntarily producing the appropriate torque based on visual feedback. Thus, with the paradigm used in this study, reflex stiffness was not modulated in a task-dependent manner.

  8. Fuel Temperature Coefficient of Reactivity

    SciTech Connect

    Loewe, W.E.

    2001-07-31

    A method for measuring the fuel temperature coefficient of reactivity in a heterogeneous nuclear reactor is presented. The method, which is used during normal operation, requires that calibrated control rods be oscillated in a special way at a high reactor power level. The value of the fuel temperature coefficient of reactivity is found from the measured flux responses to these oscillations. Application of the method in a Savannah River reactor charged with natural uranium is discussed.

  9. Wrong Signs in Regression Coefficients

    NASA Technical Reports Server (NTRS)

    McGee, Holly

    1999-01-01

    When using parametric cost estimation, it is important to note the possibility of the regression coefficients having the wrong sign. A wrong sign is defined as a sign on the regression coefficient opposite to the researcher's intuition and experience. Some possible causes for the wrong sign discussed in this paper are a small range of x's, leverage points, missing variables, multicollinearity, and computational error. Additionally, techniques for determining the cause of the wrong sign are given.

  10. Diffusion Coefficients in White Dwarfs

    NASA Astrophysics Data System (ADS)

    Saumon, D.; Starrett, C. E.; Daligault, J.

    2015-06-01

    Models of diffusion in white dwarfs universally rely on the coefficients calculated by Paquette et al. (1986). We present new calculations of diffusion coefficients based on an advanced microscopic theory of dense plasmas and a numerical simulation approach that intrinsically accounts for multiple collisions. Our method is validated against a state-of-the-art method and we present results for the diffusion of carbon ions in a helium plasma.

  11. Pediatric stiff-person syndrome with renal failure

    PubMed Central

    Kumar, M. Veerendra; Savida, P.

    2016-01-01

    Stiff-person syndrome (SPS) is an autoimmune neuronitis with progressive myoclonus and stiffness. It is a rare but treatable disorder with few case reports in children. SPS is due to autoantibodies against the enzyme glutamic acid decarboxylase which is present in neuronal and nonneuronal tissues. This is the case report of an 8-year-old boy with clinical and investigational features suggestive of SPS with associated myoglobin-induced renal failure, who completely recovered with treatment. PMID:26933366

  12. The relationships between active extensibility, and passive and active stiffness of the knee flexors.

    PubMed

    Blackburn, J Troy; Padua, Darin A; Riemann, Bryan L; Guskiewicz, Kevin M

    2004-12-01

    Insufficient active knee flexor stiffness may predispose the anterior cruciate ligament to injury. Insufficient passive stiffness may result in insufficient active stiffness. Similarly, higher levels of musculotendinous extensibility may inhibit active and passive muscle stiffness, potentially contributing to an increased risk of injury. The literature is both limited and inconsistent concerning relationships between extensibility, passive stiffness, and active stiffness. Extensibility was measured as the maximal active knee extension angle from a supine position with the hip flexed to 90 degrees . Passive stiffness was calculated as the slope of the moment-angle curve resulting from passive knee extension. Active stiffness was assessed via acceleration associated with damped oscillatory motion about the knee. Stepwise multiple regression indicated that passive stiffness accounted for 25% of active muscle stiffness variance. The linear combination of extensibility and passive stiffness explained only 2% more variance compared to passive stiffness alone. Musculotendinous extensibility was moderately related to passive muscle stiffness, and weakly related to active muscle stiffness. The moderate relationship observed between active and passive stiffness emphasizes the dependence of active muscle stiffness on cross-bridge formation, and the relatively smaller contribution from parallel elastic tissues. Additionally, heightened extensibility does not appear to be a predisposing factor for reduced muscle stiffness. PMID:15491843

  13. Calculation and measurement of the influence of flow parameters on rotordynamic coefficients in labyrinth seals

    NASA Technical Reports Server (NTRS)

    Kwanka, K.; Ortinger, W.; Steckel, J.

    1994-01-01

    First experimental investigations performed on a new test rig are presented. For a staggered labyrinth seal with fourteen cavities the stiffness coefficient and the leakage flow are measured. The experimental results are compared to calculated results which are obtained by a one-volume bulk-flow theory. A perturbation analysis is made for seven terms. It is found out that the friction factors have great impact on the dynamic coefficients. They are obtained by turbulent flow computation by a finite-volume model with the Reynolds equations used as basic equations.

  14. Therapeutic modification of arterial stiffness: An update and comprehensive review

    PubMed Central

    Wu, Ching-Fen; Liu, Pang-Yen; Wu, Tsung-Jui; Hung, Yuan; Yang, Shih-Ping; Lin, Gen-Min

    2015-01-01

    Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with long-term worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk. Additionally to life style modifications, long-term ω-3 fatty acids (fish oil) supplementation in diet may improve arterial stiffness in the population with hypertension or metabolic syndrome. Pharmacological treatment such as renin-angiotensin-aldosterone system antagonists, metformin, and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors were useful in individuals with hypertension and diabetes. In obese population with obstructive sleep apnea, weight reduction, aerobic exercise, and continuous positive airway pressure treatment may also improve arterial stiffness. In the populations with chronic inflammatory disease such as rheumatoid arthritis, a use of antibodies against tumor necrosis factor-alpha could work effectively. Other therapeutic options such as renal sympathetic nerve denervation for patients with resistant hypertension are investigated in many ongoing clinical trials. Therefore our comprehensive review provides knowledge in detail regarding many aspects of pathogenesis, measurement, and management of arterial stiffness in several populations, which would be helpful for physicians to make clinical decision. PMID:26635922

  15. Non-crossbridge stiffness in active muscle fibres.

    PubMed

    Colombini, Barbara; Nocella, Marta; Bagni, Maria Angela

    2016-01-01

    Stretching of an activated skeletal muscle induces a transient tension increase followed by a period during which the tension remains elevated well above the isometric level at an almost constant value. This excess of tension in response to stretching has been called 'static tension' and attributed to an increase in fibre stiffness above the resting value, named 'static stiffness'. This observation was originally made, by our group, in frog intact muscle fibres and has been confirmed more recently, by us, in mammalian intact fibres. Following stimulation, fibre stiffness starts to increase during the latent period well before crossbridge force generation and it is present throughout the whole contraction in both single twitches and tetani. Static stiffness is dependent on sarcomere length in a different way from crossbridge force and is independent of stretching amplitude and velocity. Static stiffness follows a time course which is distinct from that of active force and very similar to the myoplasmic calcium concentration time course. We therefore hypothesize that static stiffness is due to a calcium-dependent stiffening of a non-crossbridge sarcomere structure, such as the titin filament. According to this hypothesis, titin, in addition to its well-recognized role in determining the muscle passive tension, could have a role during muscle activity. PMID:26792325

  16. Model-Based Estimation of Active Knee Stiffness

    PubMed Central

    Pfeifer, Serge; Hardegger, Michael; Vallery, Heike; List, Renate; Foresti, Mauro; Riener, Robert; Perreault, Eric J.

    2013-01-01

    Knee joint impedance varies substantially during physiological gait. Quantifying this modulation is critical for the design of transfemoral prostheses that aim to mimic physiological limb behavior. Conventional methods for quantifying joint impedance typically involve perturbing the joint in a controlled manner, and describing impedance as the dynamic relationship between applied perturbations and corresponding joint torques. These experimental techniques, however, are difficult to apply during locomotion without impeding natural movements. In this paper, we propose a method to estimate the elastic component of knee joint impedance that depends on muscle activation, often referred to as active knee stiffness. The method estimates stiffness using a musculoskeletal model of the leg and a model for activation-dependent short-range muscle stiffness. Muscle forces are estimated from measurements including limb kinematics, kinetics and muscle electromyograms. For isometric validation, we compare model estimates to measurements involving joint perturbations; measured stiffness is 17% lower than model estimates for extension, and 42% lower for flexion torques. We show that sensitivity of stiffness estimates to common approaches for estimating muscle force is small in isometric conditions. We also make initial estimates of how knee stiffness is modulated during gait, illustrating how this approach may be used to obtain parameters relevant to the design of transfemoral prostheses. PMID:22275672

  17. Therapeutic modification of arterial stiffness: An update and comprehensive review.

    PubMed

    Wu, Ching-Fen; Liu, Pang-Yen; Wu, Tsung-Jui; Hung, Yuan; Yang, Shih-Ping; Lin, Gen-Min

    2015-11-26

    Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with long-term worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk. Additionally to life style modifications, long-term ω-3 fatty acids (fish oil) supplementation in diet may improve arterial stiffness in the population with hypertension or metabolic syndrome. Pharmacological treatment such as renin-angiotensin-aldosterone system antagonists, metformin, and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors were useful in individuals with hypertension and diabetes. In obese population with obstructive sleep apnea, weight reduction, aerobic exercise, and continuous positive airway pressure treatment may also improve arterial stiffness. In the populations with chronic inflammatory disease such as rheumatoid arthritis, a use of antibodies against tumor necrosis factor-alpha could work effectively. Other therapeutic options such as renal sympathetic nerve denervation for patients with resistant hypertension are investigated in many ongoing clinical trials. Therefore our comprehensive review provides knowledge in detail regarding many aspects of pathogenesis, measurement, and management of arterial stiffness in several populations, which would be helpful for physicians to make clinical decision.

  18. Therapeutic modification of arterial stiffness: An update and comprehensive review.

    PubMed

    Wu, Ching-Fen; Liu, Pang-Yen; Wu, Tsung-Jui; Hung, Yuan; Yang, Shih-Ping; Lin, Gen-Min

    2015-11-26

    Arterial stiffness has been recognized as a marker of cardiovascular disease and associated with long-term worse clinical outcomes in several populations. Age, hypertension, smoking, and dyslipidemia, known as traditional vascular risk factors, as well as diabetes, obesity, and systemic inflammation lead to both atherosclerosis and arterial stiffness. Targeting multiple modifiable risk factors has become the main therapeutic strategy to improve arterial stiffness in patients at high cardiovascular risk. Additionally to life style modifications, long-term ω-3 fatty acids (fish oil) supplementation in diet may improve arterial stiffness in the population with hypertension or metabolic syndrome. Pharmacological treatment such as renin-angiotensin-aldosterone system antagonists, metformin, and 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors were useful in individuals with hypertension and diabetes. In obese population with obstructive sleep apnea, weight reduction, aerobic exercise, and continuous positive airway pressure treatment may also improve arterial stiffness. In the populations with chronic inflammatory disease such as rheumatoid arthritis, a use of antibodies against tumor necrosis factor-alpha could work effectively. Other therapeutic options such as renal sympathetic nerve denervation for patients with resistant hypertension are investigated in many ongoing clinical trials. Therefore our comprehensive review provides knowledge in detail regarding many aspects of pathogenesis, measurement, and management of arterial stiffness in several populations, which would be helpful for physicians to make clinical decision. PMID:26635922

  19. Converting Sabine absorption coefficients to random incidence absorption coefficients.

    PubMed

    Jeong, Cheol-Ho

    2013-06-01

    Absorption coefficients measured by the chamber method are referred to as Sabine absorption coefficients, which sometimes exceed unity due to the finite size of a sample and non-uniform intensity in the reverberation chambers under test. In this study, conversion methods from Sabine absorption coefficients to random incidence absorption coefficients are proposed. The overestimations of the Sabine absorption coefficient are investigated theoretically based on Miki's model for porous absorbers backed by a rigid wall or an air cavity, resulting in conversion factors. Additionally, three optimizations are suggested: An optimization method for the surface impedances for locally reacting absorbers, the flow resistivity for extendedly reacting absorbers, and the flow resistance for fabrics. With four porous type absorbers, the conversion methods are validated. For absorbers backed by a rigid wall, the surface impedance optimization produces the best results, while the flow resistivity optimization also yields reasonable results. The flow resistivity and flow resistance optimization for extendedly reacting absorbers are also found to be successful. However, the theoretical conversion factors based on Miki's model do not guarantee reliable estimations, particularly at frequencies below 250 Hz and beyond 2500 Hz.

  20. Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts.

    PubMed

    Hughson, Richard L; Robertson, Andrew D; Arbeille, Philippe; Shoemaker, J Kevin; Rush, James W E; Fraser, Katelyn S; Greaves, Danielle K

    2016-03-01

    Removal of the normal head-to-foot gravity vector and chronic weightlessness during spaceflight might induce cardiovascular and metabolic adaptations related to changes in arterial pressure and reduction in physical activity. We tested hypotheses that stiffness of arteries located above the heart would be increased postflight, and that blood biomarkers inflight would be consistent with changes in vascular function. Possible sex differences in responses were explored in four male and four female astronauts who lived on the International Space Station for 6 mo. Carotid artery distensibility coefficient (P = 0.005) and β-stiffness index (P = 0.006) reflected 17-30% increases in arterial stiffness when measured within 38 h of return to Earth compared with preflight. Spaceflight-by-sex interaction effects were found with greater changes in β-stiffness index in women (P = 0.017), but greater changes in pulse wave transit time in men (P = 0.006). Several blood biomarkers were changed from preflight to inflight, including an increase in an index of insulin resistance (P < 0.001) with a spaceflight-by-sex term suggesting greater change in men (P = 0.034). Spaceflight-by-sex interactions for renin (P = 0.016) and aldosterone (P = 0.010) indicated greater increases in women than men. Six-month spaceflight caused increased arterial stiffness. Altered hydrostatic arterial pressure gradients as well as changes in insulin resistance and other biomarkers might have contributed to alterations in arterial properties, including sex differences between male and female astronauts.

  1. Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts.

    PubMed

    Hughson, Richard L; Robertson, Andrew D; Arbeille, Philippe; Shoemaker, J Kevin; Rush, James W E; Fraser, Katelyn S; Greaves, Danielle K

    2016-03-01

    Removal of the normal head-to-foot gravity vector and chronic weightlessness during spaceflight might induce cardiovascular and metabolic adaptations related to changes in arterial pressure and reduction in physical activity. We tested hypotheses that stiffness of arteries located above the heart would be increased postflight, and that blood biomarkers inflight would be consistent with changes in vascular function. Possible sex differences in responses were explored in four male and four female astronauts who lived on the International Space Station for 6 mo. Carotid artery distensibility coefficient (P = 0.005) and β-stiffness index (P = 0.006) reflected 17-30% increases in arterial stiffness when measured within 38 h of return to Earth compared with preflight. Spaceflight-by-sex interaction effects were found with greater changes in β-stiffness index in women (P = 0.017), but greater changes in pulse wave transit time in men (P = 0.006). Several blood biomarkers were changed from preflight to inflight, including an increase in an index of insulin resistance (P < 0.001) with a spaceflight-by-sex term suggesting greater change in men (P = 0.034). Spaceflight-by-sex interactions for renin (P = 0.016) and aldosterone (P = 0.010) indicated greater increases in women than men. Six-month spaceflight caused increased arterial stiffness. Altered hydrostatic arterial pressure gradients as well as changes in insulin resistance and other biomarkers might have contributed to alterations in arterial properties, including sex differences between male and female astronauts. PMID:26747504

  2. Direct measurement of human ankle stiffness during quiet standing: the intrinsic mechanical stiffness is insufficient for stability

    PubMed Central

    Loram, Ian D; Lakie, Martin

    2002-01-01

    During quiet standing the human ‘inverted pendulum’ sways irregularly. In previous work where subjects balanced a real inverted pendulum, we investigated what contribution the intrinsic mechanical ankle stiffness makes to achieve stability. Using the results of a plausible model, we suggested that intrinsic ankle stiffness is inadequate for providing stability. Here, using a piezo-electric translator we applied small, unobtrusive mechanical perturbations to the foot while the subject was standing freely. These short duration perturbations had a similar size and velocity to movements which occur naturally during quiet standing, and they produced no evidence of any stretch reflex response in soleus, or gastrocnemius. Direct measurement confirms our earlier conclusion; intrinsic ankle stiffness is not quite sufficient to stabilise the body or pendulum. On average the directly determined intrinsic stiffness is 91 ± 23 % (mean ± s.d.) of that necessary to provide minimal stabilisation. The stiffness was substantially constant, increasing only slightly with ankle torque. This stiffness cannot be neurally regulated in quiet standing. Thus we attribute this stiffness to the foot, Achilles’ tendon and aponeurosis rather than the activated calf muscle fibres. Our measurements suggest that the triceps surae muscles maintain balance via a spring-like element which is itself too compliant to guarantee stability. The implication is that the brain cannot set ankle stiffness and then ignore the control task because additional modulation of torque is required to maintain balance. We suggest that the triceps surae muscles maintain balance by predictively controlling the proximal offset of the spring-like element in a ballistic-like manner. PMID:12482906

  3. Dynamic stiffness matrix of thin-walled composite I-beam with symmetric and arbitrary laminations

    NASA Astrophysics Data System (ADS)

    Kim, Nam-Il; Shin, Dong Ku; Park, Young-Suk

    2008-11-01

    For the spatially coupled free vibration analysis of thin-walled composite I-beam with symmetric and arbitrary laminations, the exact dynamic stiffness matrix based on the solution of the simultaneous ordinary differential equations is presented. For this, a general theory for the vibration analysis of composite beam with arbitrary lamination including the restrained warping torsion is developed by introducing Vlasov's assumption. Next, the equations of motion and force-displacement relationships are derived from the energy principle and the first order of transformed simultaneous differential equations are constructed by using the displacement state vector consisting of 14 displacement parameters. Then explicit expressions for displacement parameters are derived and the exact dynamic stiffness matrix is determined using force-displacement relationships. In addition, the finite-element (FE) procedure based on Hermitian interpolation polynomials is developed. To verify the validity and the accuracy of this study, the numerical solutions are presented and compared with analytical solutions, the results from available references and the FE analysis using the thin-walled Hermitian beam elements. Particular emphasis is given in showing the phenomenon of vibrational mode change, the effects of increase of the modulus and the bending-twisting coupling stiffness for beams with various boundary conditions.

  4. Electron temperature critical gradient and transport stiffness in DIII-D

    NASA Astrophysics Data System (ADS)

    Smith, S. P.; Petty, C. C.; White, A. E.; Holland, C.; Bravenec, R.; Austin, M. E.; Zeng, L.; Meneghini, O.

    2015-08-01

    In a continuing effort to validate turbulent transport models, the electron energy flux has been probed as a function of electron temperature gradient on the DIII-D tokamak. In the scan of gradient, a critical electron temperature gradient has been found in the electron heat fluxes and stiffness at various radii in L-mode plasmas. The TGLF reduced turbulent transport model (Staebler et al 2007 Phys. Plasmas 14 055909) and full gyrokinetic GYRO model (Candy and Waltz 2003 J. Comput. Phys. 186 545) recover the general trend of increasing electron energy flux with increasing electron temperature gradient scale length, but they do not predict the absolute level of transport at all radii and gradients. Comparing the experimental observations of incremental (heat pulse) diffusivity and stiffness to the models’ reveals that TGLF reproduces the trends in increasing diffusivity and stiffness with increasing electron temperature gradient scale length with a critical gradient behavior. The critical gradient of TGLF is found to have a dependence on q95, contrary to the independence of the experimental critical gradient from q95.

  5. Annular honeycomb seals: Test results for leakage and rotordynamic coefficients; comparisons to labyrinth and smooth configurations

    NASA Technical Reports Server (NTRS)

    Childs, Dara W.; Elrod, David; Hale, Keith

    1989-01-01

    Test results are presented for leakage and rotordynamic coefficients for seven honeycomb seals. All seals have the same radius, length, and clearance; however, the cell depths and diameters are varied. Rotordynamic data, which are presented, consist of the direct and cross-coupled stiffness coefficients and the direct damping coefficients. The rotordynamic-coefficient data show a considerable sensitivity to changes in cell dimensions; however, no clear trends are identifiable. Comparisons of test data for the honeycomb seals with labyrinth and smooth annular seals show the honeycomb seal had the best sealing (minimum leakage) performance, followed in order by the labyrinth and smooth seals. For prerotated fluid entering the seal, in the direction of shaft rotation, the honeycomb seal has the best rotordynamic stability followed in order by the labyrinth and smooth. For no prerotation, or fluid prerotation against shaft rotation, the labyrinth seal has the best rotordynamic stability followed in order by the smooth and honeycomb seals.

  6. Annular honeycomb seals: Test results for leakage and rotordynamic coefficients - Comparisons to labyrinth and smooth configurations

    NASA Technical Reports Server (NTRS)

    Childs, D.; Elrod, D.; Hale, K.

    1989-01-01

    Test results are presented for leakage and rotordynamic coefficients for seven honeycomb seals. All seals have the same radius, length, and clearance; however, the cell depths and diameters are varied. Rotordynamic data, which are presented, consist of the direct and cross-coupled stiffness coefficients and the direct damping coefficients. The rotordynamic-coefficient data show a considerable sensitivity to changes in cell dimensions; however, no clear trends are identifiable. Comparisons of test data for the honeycomb seals with labyrinth and smooth annular seals shows the honeycomb seal had the best sealing (minimum leakage) performance, followed in order by the labyrinth and smooth seals. For prerotated fluids entering the seal, in the direction of shaft rotation, the honeycomb seal has the best rotordynamic stability followed in order by the labyrinth and smooth. For no prerotation, or fluid prerotation against shaft rotation, the labyrinth seal has the best rotordynamic stability followed in order by the smooth and honeycomb seals.

  7. Hydration Status Is Associated with Aortic Stiffness, but Not with Peripheral Arterial Stiffness, in Chronically Hemodialysed Patients

    PubMed Central

    Bia, Daniel; Galli, Cintia; Valtuille, Rodolfo; Zócalo, Yanina; Wray, Sandra A.; Armentano, Ricardo L.; Cabrera Fischer, Edmundo I.

    2015-01-01

    Background. Adequate fluid management could be essential to minimize high arterial stiffness observed in chronically hemodialyzed patients (CHP). Aim. To determine the association between body fluid status and central and peripheral arterial stiffness levels. Methods. Arterial stiffness was assessed in 65 CHP by measuring the pulse wave velocity (PWV) in a central arterial pathway (carotid-femoral) and in a peripheral pathway (carotid-brachial). A blood pressure-independent regional arterial stiffness index was calculated using PWV. Volume status was assessed by whole-body multiple-frequency bioimpedance. Patients were first observed as an entire group and then divided into three different fluid status-related groups: normal, overhydration, and dehydration groups. Results. Only carotid-femoral stiffness was positively associated (P < 0.05) with the hydration status evaluated through extracellular/intracellular fluid, extracellular/Total Body Fluid, and absolute and relative overhydration. Conclusion. Volume status and overload are associated with central, but not peripheral, arterial stiffness levels with independence of the blood pressure level, in CHP. PMID:26167301

  8. A piezoelectric-based infinite stiffness generation method for strain-type load sensors

    NASA Astrophysics Data System (ADS)

    Zhang, Shuwen; Shao, Shubao; Chen, Jie; Xu, Minglong

    2015-11-01

    Under certain application conditions like nanoindentation technology and the mechanical property measurement of soft materials, the elastic deformation of strain-type load sensors affects their displacement measurement accuracy. In this work, a piezoelectric-based infinite stiffness generation method for strain-type load sensors that compensates for this elastic deformation is presented. The piezoelectric material-based deformation compensation method is proposed. An Hottinger Baldwin Messtechnik GmbH (HBM) Z30A/50N load sensor acts as the foundation of the method presented in this work. The piezoelectric stack is selected based on its size, maximum deformation value, blocking force and stiffness. Then, a clamping and fixing structure is designed to integrate the HBM sensor with the piezoelectric stack. The clamping and fixing structure, piezoelectric stack and HBM load sensor comprise the sensing part of the enhanced load sensor. The load-deformation curve and the voltage-deformation curve of the enhanced load sensor are then investigated experimentally. Because a hysteresis effect exists in the piezoelectric structure, the relationship between the control signal and the deformation value of the piezoelectric material is nonlinear. The hysteresis characteristic in a quasi-static condition is studied and fitted using a quadratic polynomial, and its coefficients are analyzed to enable control signal prediction. Applied arithmetic based on current theory and the fitted data is developed to predict the control signal. Finally, the experimental effects of the proposed method are presented. It is shown that when a quasi-static load is exerted on this enhanced strain-type load sensor, the deformation is reduced and the equivalent stiffness appears to be almost infinite.

  9. Muscle Synergies Heavily Influence the Neural Control of Arm Endpoint Stiffness and Energy Consumption

    PubMed Central

    Inouye, Joshua M.; Valero-Cuevas, Francisco J.

    2016-01-01

    Much debate has arisen from research on muscle synergies with respect to both limb impedance control and energy consumption. Studies of limb impedance control in the context of reaching movements and postural tasks have produced divergent findings, and this study explores whether the use of synergies by the central nervous system (CNS) can resolve these findings and also provide insights on mechanisms of energy consumption. In this study, we phrase these debates at the conceptual level of interactions between neural degrees of freedom and tasks constraints. This allows us to examine the ability of experimentally-observed synergies—correlated muscle activations—to control both energy consumption and the stiffness component of limb endpoint impedance. In our nominal 6-muscle planar arm model, muscle synergies and the desired size, shape, and orientation of endpoint stiffness ellipses, are expressed as linear constraints that define the set of feasible muscle activation patterns. Quadratic programming allows us to predict whether and how energy consumption can be minimized throughout the workspace of the limb given those linear constraints. We show that the presence of synergies drastically decreases the ability of the CNS to vary the properties of the endpoint stiffness and can even preclude the ability to minimize energy. Furthermore, the capacity to minimize energy consumption—when available—can be greatly affected by arm posture. Our computational approach helps reconcile divergent findings and conclusions about task-specific regulation of endpoint stiffness and energy consumption in the context of synergies. But more generally, these results provide further evidence that the benefits and disadvantages of muscle synergies go hand-in-hand with the structure of feasible muscle activation patterns afforded by the mechanics of the limb and task constraints. These insights will help design experiments to elucidate the interplay between synergies and the

  10. Muscle Synergies Heavily Influence the Neural Control of Arm Endpoint Stiffness and Energy Consumption.

    PubMed

    Inouye, Joshua M; Valero-Cuevas, Francisco J

    2016-02-01

    Much debate has arisen from research on muscle synergies with respect to both limb impedance control and energy consumption. Studies of limb impedance control in the context of reaching movements and postural tasks have produced divergent findings, and this study explores whether the use of synergies by the central nervous system (CNS) can resolve these findings and also provide insights on mechanisms of energy consumption. In this study, we phrase these debates at the conceptual level of interactions between neural degrees of freedom and tasks constraints. This allows us to examine the ability of experimentally-observed synergies--correlated muscle activations--to control both energy consumption and the stiffness component of limb endpoint impedance. In our nominal 6-muscle planar arm model, muscle synergies and the desired size, shape, and orientation of endpoint stiffness ellipses, are expressed as linear constraints that define the set of feasible muscle activation patterns. Quadratic programming allows us to predict whether and how energy consumption can be minimized throughout the workspace of the limb given those linear constraints. We show that the presence of synergies drastically decreases the ability of the CNS to vary the properties of the endpoint stiffness and can even preclude the ability to minimize energy. Furthermore, the capacity to minimize energy consumption--when available--can be greatly affected by arm posture. Our computational approach helps reconcile divergent findings and conclusions about task-specific regulation of endpoint stiffness and energy consumption in the context of synergies. But more generally, these results provide further evidence that the benefits and disadvantages of muscle synergies go hand-in-hand with the structure of feasible muscle activation patterns afforded by the mechanics of the limb and task constraints. These insights will help design experiments to elucidate the interplay between synergies and the mechanisms

  11. Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging.

    PubMed

    Scuteri, Angelo; Morrell, Christopher H; Orrù, Marco; Strait, James B; Tarasov, Kirill V; Ferreli, Liana Anna Pina; Loi, Francesco; Pilia, Maria Grazia; Delitala, Alessandro; Spurgeon, Harold; Najjar, Samer S; AlGhatrif, Majd; Lakatta, Edward G

    2014-12-01

    The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 community-dwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages>40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men.

  12. Transport coefficients of heavy baryons

    NASA Astrophysics Data System (ADS)

    Tolos, Laura; Torres-Rincon, Juan M.; Das, Santosh K.

    2016-08-01

    We compute the transport coefficients (drag and momentum diffusion) of the low-lying heavy baryons Λc and Λb in a medium of light mesons formed at the later stages of high-energy heavy-ion collisions. We employ the Fokker-Planck approach to obtain the transport coefficients from unitarized baryon-meson interactions based on effective field theories that respect chiral and heavy-quark symmetries. We provide the transport coefficients as a function of temperature and heavy-baryon momentum, and analyze the applicability of certain nonrelativistic estimates. Moreover we compare our outcome for the spatial diffusion coefficient to the one coming from the solution of the Boltzmann-Uehling-Uhlenbeck transport equation, and we find a very good agreement between both calculations. The transport coefficients for Λc and Λb in a thermal bath will be used in a subsequent publication as input in a Langevin evolution code for the generation and propagation of heavy particles in heavy-ion collisions at LHC and RHIC energies.

  13. Ultraprecision, high stiffness CNC grinding machines for ductile mode grinding of brittle materials

    NASA Astrophysics Data System (ADS)

    McKeown, Patrick A.; Carlisle, Keith; Shore, Paul; Read, R. F.

    1990-10-01

    Under certain controlled conditions it is now possible to machine brittle materials such as glasses and ceramics using single or multi-point diamond tools (grinding), so that material is removed by plastic flow, leaving crack-free surfaces. This process is called 'shear' or 'ductile' mode grinding. It represents a major breakthrough in modern manufacturing engineering since it promises to enable: - complex optical components, both transmission and reflecting to be generated by advanced CNC machines with very little (or even zero) subsequent polishing. - complex shaped components such as turbine blades, nozzle guide vanes, etc. to be finish machined after near net shape forming, to high precision in advanced ceramics such as silicon nitride, without inducing micro-cracking and thus lowering ultimate rupture strength and fatigue life. Ductile mode "damage free" grinding occurs when the volume of materials stressed by each grit of the grinding wheel is small enough to yield rather than exhibit brittle fracture, i.e. cracking. In practice, this means maintaining the undeformed chip thickness to below the ductile-brittle transition value; this varies from material to material but is generally in the order of 0.1 pm or 100 nm, (hence the term "nanogrinding" is sometimes used) . Thus the critical factors for operating successfully in the ductile regime are machine system accuracy and dynamic stiffness between each grit and the workpiece. In detail this means: (i) High precision 'truing' of the diamond grits, together with dressing of the wheel bond to ensure adequate ' openness'; (ii) Design and build of the grinding wheel spindle with very high dynamic stiffness; error motions, radial and axial, must be considerably less than 100 nfl. (iii) Design and build of the workpiece carriage motion system with very high dynamic stiffness; error motions, linear or rotary, must be well within 100 nm. (iv) Smooth, rumble-free, high-stiffness servo-drives controlling the motions

  14. POA 02-2 ATHEROGENIC VASCULAR STIFFNESS AND HYPERTENSION: CAUSE OR EFFECT?

    PubMed

    Avolio, Alberto

    2016-09-01

    Blood vessels function as conduits for distribution of blood throughout the circulatory system. Large arteries, in addition to the essential conduit function, also serve to dampen the effect of pulsatile ventricular ejection that generates pulsatile pressure with each cardiac cycle; that is, they exhibit a 'cushion' function. The conduit function can be compromised by intimal effects that cause obstruction to flow, generally attributed to plaque formation due to intimal changes affected by atherosclerotic processes. The cushion function is affected by medial changes altering the wall stiffness, and so the capacity of arteries to absorb pulsatile energy. This modulates pulse pressure through changes in wall stiffness and vessel compliance and characteristics of wave propagation. In addition, these changes are further affected by arterial pressure. Intimal changes related to obstructive phenomena are generally thought to be related to atherosclerosis, and medial change affecting vessel buffering capacity related to arteriosclerosis. This lecture explores aspects that characterise the potential inter-relationship between the two phenomena and arterial pressure. With advances in molecular biology, imaging and computational modelling, pathways involved in cell-signalling affecting intimal changes through endothelial function and medial changes through both endothelial and smooth muscle function are increasingly being identified. The nitric oxide pathway has been shown to influence protein expression affecting the stiffness of the extracellular matrix through alteration of cross-link formation. In turn, bioavailablity of endothelial nitric oxide is also affected by wall stiffness. Changes in distribution of internal wall stress due to altered structure of the wall matrix can alter the mechanotransduction effects on the endothelial cell, modifying intimal changes. The phenotypic transdifferentiation of the smooth muscle cell is associated with changes in structural

  15. Lifetime vigorous but not light-to-moderate habitual physical activity impacts favorably on carotid stiffness in young adults: the amsterdam growth and health longitudinal study.

    PubMed

    van de Laar, Roel J; Ferreira, Isabel; van Mechelen, Willem; Prins, Martin H; Twisk, Jos W; Stehouwer, Coen D

    2010-01-01

    Higher levels of habitual physical activity favorably impact on arterial stiffness. It is not clear, however, whether lifetime habitual physical activities of different intensities carry the same protective effect and to what extent any such effect is mediated by other biological cardiovascular risk factors. We, therefore, examined longitudinal data on habitual physical activity and cardiovascular risk factors (8 repeated measures between the ages of 13 and 36 years) in 373 subjects in whom stiffness estimates of the carotid artery were assessed at age 36 years using noninvasive ultrasonography. The time spent in habitual physical activities (in minutes per week) throughout the longitudinal period was compared between subjects across tertiles of the following stiffness estimates: beta-stiffness index, distensibility and compliance coefficients, and the Young's elastic modulus. After adjustments for sex, body height, and other lifestyle variables, subjects in the highest tertile of the beta-stiffness index (ie, with stiffer arteries) had spent, on average, throughout the longitudinal period, less time in vigorous (-26.5 [95% CI: -45.9 to -7.1]) but less so in light-to-moderate habitual physical activities (-11.2 [95% CI: -53.5 to 31.1]) as compared with subjects in the lowest tertile. The difference in time spent in vigorous activities was greatly attenuated when further adjusted for blood lipids, cardiorespiratory fitness, fat distribution, resting heart rate, and mean arterial pressure (to -11.2 [95% CI: -29.4 to 7.0]). Similar results were found for the other stiffness estimates. Promoting vigorous intensity physical activities among the healthy young may, therefore, prevent arterial stiffness and related cardiovascular sequelae later in life, partly through its favorable impact on other biological cardiovascular risk factors.

  16. Analysis of internal conversion coefficients

    PubMed

    Coursol; Gorozhankin; Yakushev; Briancon; Vylov

    2000-03-01

    An extensive database has been assembled that contains the three most widely used sets of calculated internal conversion coefficients (ICC): [Hager R.S., Seltzer E.C., 1968. Internal conversion tables. K-, L-, M-shell Conversion coefficients for Z = 30 to Z = 103, Nucl. Data Tables A4, 1-237; Band I.M., Trzhaskovskaya M.B., 1978. Tables of gamma-ray internal conversion coefficients for the K-, L- and M-shells, 10 < or = Z < or = 104, Special Report of Leningrad Nuclear Physics Institute; Rosel F., Fries H.M., Alder K., Pauli H.C., 1978. Internal conversion coefficients for all atomic shells, At. Data Nucl. Data Tables 21, 91-289] and also includes new Dirac Fock calculations [Band I.M. and Trzhaskovskaya M.B., 1993. Internal conversion coefficients for low-energy nuclear transitions, At. Data Nucl. Data Tables 55, 43-61]. This database is linked to a computer program to plot ICCs and their combinations (sums and ratios) as a function of Z and energy, as well as relative deviations of ICC or their combinations for any pair of tabulated data. Examples of these analyses are presented for the K-shell and total ICCs of the gamma-ray standards [Hansen H.H., 1985. Evaluation of K-shell and total internal conversion coefficients for some selected nuclear transitions, Eur. Appl. Res. Rept. Nucl. Sci. Tech. 11.6 (4) 777-816] and for the K-shell and total ICCs of high multipolarity transitions (total, K-, L-, M-shells of E3 and M3 and K-shell of M4). Experimental data sets are also compared with the theoretical values of these specific calculations. PMID:10724406

  17. Evaluation of fatigue life of CRM-reinforced SMA and its relationship to dynamic stiffness.

    PubMed

    Mashaan, Nuha Salim; Karim, Mohamed Rehan; Abdel Aziz, Mahrez; Ibrahim, Mohd Rasdan; Katman, Herda Yati; Koting, Suhana

    2014-01-01

    Fatigue cracking is an essential problem of asphalt concrete that contributes to pavement damage. Although stone matrix asphalt (SMA) has significantly provided resistance to rutting failure, its resistance to fatigue failure is yet to be fully addressed. The aim of this study is to evaluate the effect of crumb rubber modifier (CRM) on stiffness and fatigue properties of SMA mixtures at optimum binder content, using four different modification levels, namely, 6%, 8%, 10%, and 12% CRM by weight of the bitumen. The testing undertaken on the asphalt mix comprises the dynamic stiffness (indirect tensile test), dynamic creep (repeated load creep), and fatigue test (indirect tensile fatigue test) at temperature of 25°C. The indirect tensile fatigue test was conducted at three different stress levels (200, 300, and 400 kPa). Experimental results indicate that CRM-reinforced SMA mixtures exhibit significantly higher fatigue life compared to the mixtures without CRM. Further, higher correlation coefficient was obtained between the fatigue life and resilient modulus as compared to permanent strain; thus resilient modulus might be a more reliable indicator in evaluating the fatigue life of asphalt mixture.

  18. Ultrasound imaging system for measuring stiffness variation in the fingerpad skin in vivo

    NASA Astrophysics Data System (ADS)

    Wu, Wan-Chen; Raju, Balasundar I.; Srinivasan, Mandayam A.

    2005-04-01

    An elasticity imaging system was developed for measuring the stiffness variation at different depths of the human fingerpad skin in vivo. In this system, ultrasonic backscatter microscopy (UBM) with a single high frequency (28MHz) transducer was employed to obtain data on tissue heterogeneity at high axial resolution (~25 mm). The dorsal side of the finger was fixed on a manually controlled vertical stage and an acrylic indentor was applied to the fingerpad. A slit cut vertically through the indentor at the center and a piece of transparency sheet attached to the bottom allowed most of the ultrasound power to pass though while maintaining a flat surface in contact with the skin. With the assumption that the skin can be modeled as a semi-infinite layered structure, only data from a single A-line was obtained for strain analysis. The data at continuous indentation steps were cross-correlated to calculate the displacement at different spots along the depth. The de-correlation at certain regions was resolved by removing the data points with lower correlation coefficients, and curve fitting was applied to overcome the lack of resolution due to sampling. The fingerpads of 10 human subjects were tested in vivo and a gelatin phantom was made and tested for comparison. The results showed that even though some data were degraded due to the hypoechoic nature of the subcutaneous fat, the axial strain profile through the skin thickness (up to 3mm in depth) could be extracted as a measure of the stiffness variation.

  19. Active pneumatic vibration isolation system using negative stiffness structures for a vehicle seat

    NASA Astrophysics Data System (ADS)

    Danh, Le Thanh; Ahn, Kyoung Kwan

    2014-02-01

    In this paper, an active pneumatic vibration isolation system using negative stiffness structures (NSS) for a vehicle seat in low excitation frequencies is proposed, which is named as an active system with NSS. Here, the negative stiffness structures (NSS) are used to minimize the vibratory attraction of a vehicle seat. Owing to the time-varying and nonlinear behavior of the proposed system, it is not easy to build an accurate dynamic for model-based controller design. Thus, an adaptive intelligent backstepping controller (AIBC) is designed to manage the system operation for high-isolation effectiveness. In addition, an auxiliary control effort is also introduced to eliminate the effect of the unpredictable perturbations. Moreover, a radial basis function neural network (RBFNN) model is utilized to estimate the optimal gain of the auxiliary control effort. Final control input and the adaptive law for updating coefficients of the approximate series can be obtained step by step using a suitable Lyapunov function. Afterward, the isolation performance of the proposed system is assessed experimentally. In addition, the effectiveness of the designed controller for the proposed system is also compared with that of the traditional backstepping controller (BC). The experimental results show that the isolation effectiveness of the proposed system is better than that of the active system without NSS. Furthermore, the undesirable chattering phenomenon in control effort is quite reduced by the estimation mechanism. Finally, some concluding remarks are given at the end of the paper.

  20. Evaluation of Fatigue Life of CRM-Reinforced SMA and Its Relationship to Dynamic Stiffness

    PubMed Central

    Mashaan, Nuha Salim; Karim, Mohamed Rehan; Abdel Aziz, Mahrez; Ibrahim, Mohd Rasdan; Katman, Herda Yati

    2014-01-01

    Fatigue cracking is an essential problem of asphalt concrete that contributes to pavement damage. Although stone matrix asphalt (SMA) has significantly provided resistance to rutting failure, its resistance to fatigue failure is yet to be fully addressed. The aim of this study is to evaluate the effect of crumb rubber modifier (CRM) on stiffness and fatigue properties of SMA mixtures at optimum binder content, using four different modification levels, namely, 6%, 8%, 10%, and 12% CRM by weight of the bitumen. The testing undertaken on the asphalt mix comprises the dynamic stiffness (indirect tensile test), dynamic creep (repeated load creep), and fatigue test (indirect tensile fatigue test) at temperature of 25°C. The indirect tensile fatigue test was conducted at three different stress levels (200, 300, and 400 kPa). Experimental results indicate that CRM-reinforced SMA mixtures exhibit significantly higher fatigue life compared to the mixtures without CRM. Further, higher correlation coefficient was obtained between the fatigue life and resilient modulus as compared to permanent strain; thus resilient modulus might be a more reliable indicator in evaluating the fatigue life of asphalt mixture. PMID:25050406

  1. Transport coefficients of gluonic fluid

    SciTech Connect

    Das, Santosh K.; Alam, Jan-e

    2011-06-01

    The shear ({eta}) and bulk ({zeta}) viscous coefficients have been evaluated for a gluonic fluid. The elastic, gg{yields}gg and the inelastic, number nonconserving, gg{yields}ggg processes have been considered as the dominant perturbative processes in evaluating the viscous coefficients to entropy density (s) ratios. Recently the processes: gg{yields}ggg has been revisited and a correction to the widely used Gunion-Bertsch (GB) formula has been obtained. The {eta} and {zeta} have been evaluated for gluonic fluid with the formula recently derived. At large {alpha}{sub s} the value of {eta}/s approaches its lower bound, {approx}1/4{pi}.

  2. Semi-active damping with negative stiffness for multi-mode cable vibration mitigation: approximate collocated control solution

    NASA Astrophysics Data System (ADS)

    Weber, F.; Distl, H.

    2015-11-01

    This paper derives an approximate collocated control solution for the mitigation of multi-mode cable vibration by semi-active damping with negative stiffness based on the control force characteristics of clipped linear quadratic regulator (LQR). The control parameters are derived from optimal modal viscous damping and corrected in order to guarantee that both the equivalent viscous damping coefficient and the equivalent stiffness coefficient of the semi-active cable damper force are equal to their desired counterparts. The collocated control solution with corrected control parameters is numerically validated by free decay tests of the first four cable modes and combinations of these modes. The results of the single-harmonic tests demonstrate that the novel approach yields 1.86 times more cable damping than optimal modal viscous damping and 1.87 to 2.33 times more damping compared to a passive oil damper whose viscous damper coefficient is optimally tuned to the targeted mode range of the first four modes. The improvement in case of the multi-harmonic vibration tests, i.e. when modes 1 and 3 and modes 2 and 4 are vibrating at the same time, is between 1.55 and 3.81. The results also show that these improvements are obtained almost independent of the cable anti-node amplitude. Thus, the proposed approximate real-time applicable collocated semi-active control solution which can be realized by magnetorheological dampers represents a promising tool for the efficient mitigation of stay cable vibrations.

  3. Extended graphynes: simple scaling laws for stiffness, strength and fracture

    NASA Astrophysics Data System (ADS)

    Cranford, Steven W.; Brommer, Dieter B.; Buehler, Markus J.

    2012-11-01

    The mono-atomistic structure and chemical stability of graphene provides a promising platform to design a host of novel graphene-like materials. Using full atomistic first-principles based ReaxFF molecular dynamics, here we perform a systematic comparative study of the stability, structural and mechanical properties of graphynes - a variation of the sp2 carbon motif wherein the characteristic hexagons of graphene are linked by sp1 acetylene (single- and triple-bond) carbyne-like chains. The introduction of acetylene links introduces an effective penalty in terms of stability, elastic modulus (i.e., stiffness), and failure strength, which can be predicted as a function of acetylene repeats, or, equivalently, lattice spacing. We quantify the mechanical properties of experimental accessible graphdiyne, with a modulus on the order of 470 to 580 GPa and a ultimate strength on the order of 36 GPa to 46 GPa (direction dependent). We derive general scaling laws for the cumulative effects of additional acetylene repeats, formulated through a simple discrete spring-network framework, allowing extrapolation of mechanical performance to highly extended graphyne structures. Onset of local tensile buckling results in a transitional regime characterized by a severe reduction of strength (ultimate stress), providing a new basis for scaling extended structures. Simple fracture simulations support the scaling functions, while uncovering a ``two-tier'' failure mode for extended graphynes, wherein structural realignment facilitates stress transfer beyond initial failure. Finally, the specific modulus and strength (normalized by areal density) is found to be near-constant, suggesting applications for light-weight, yet structurally robust molecular components.

  4. Comparative Analysis of the Flexural Stiffness of Pinniped Vibrissae

    PubMed Central

    Ginter Summarell, Carly C.; Ingole, Sudeep; Fish, Frank E.; Marshall, Christopher D.

    2015-01-01

    Vibrissae are important components of the mammalian tactile sensory system and are used to detect vibrotactile stimuli in the environment. Pinnipeds have the largest and most highly innervated vibrissae among mammals, and the hair shafts function as a biomechanical filter spanning the environmental stimuli and the neural mechanoreceptors deep in the follicle-sinus complex. Therefore, the material properties of these structures are critical in transferring vibrotactile information to the peripheral nervous system. Vibrissae were tested as cantilever beams and their flexural stiffness (EI) was measured to test the hypotheses that the shape of beaded vibrissae reduces EI and that vibrissae are anisotropic. EI was measured at two locations on each vibrissa, 25% and 50% of the overall length, and at two orientations to the point force. EI differed in orientations that were normal to each other, indicating a functional anisotropy. Since vibrissae taper from base to tip, the second moment of area (I) was lower at 50% than 25% of total length. The anterior orientation exhibited greater EI values at both locations compared to the dorsal orientation for all species. Smooth vibrissae were generally stiffer than beaded vibrissae. The profiles of beaded vibrissae are known to decrease the amplitude of vibrations when protruded into a flow field. The lower EI values of beaded vibrissae, along with the reduced vibrations, may function to enhance the sensitivity of mechanoreceptors to detection of small changes in flow from swimming prey by increasing the signal to noise ratio. This study builds upon previous morphological and hydrodynamic analyses of vibrissae and is the first comparative study of the mechanical properties of pinniped vibrissae. PMID:26132102

  5. Direct Extraction of One-loop Integral Coefficients

    SciTech Connect

    Forde, Darren

    2007-04-16

    We present a general procedure for obtaining the coefficients of the scalar bubble and triangle integral functions of one-loop amplitudes. Coefficients are extracted by considering two-particle and triple unitarity cuts of the corresponding bubble and triangle integral functions. After choosing a specific parameterization of the cut loop momentum we can uniquely identify the coefficients of the desired integral functions simply by examining the behavior of the cut integrand as the unconstrained parameters of the cut loop momentum approach infinity. In this way we can produce compact forms for scalar integral coefficients. Applications of this method are presented for both QCD and electroweak processes, including an alternative form for the recently computed three-mass triangle coefficient in the six-photon amplitude A{sub 6}(1{sup -}, 2{sup +}, 3{sup -}, 4{sup +}, 5{sup -}, 6{sup +}). The direct nature of this extraction procedure allows for a very straightforward automation of the procedure.

  6. A new correlation coefficient for bivariate time-series data

    NASA Astrophysics Data System (ADS)

    Erdem, Orhan; Ceyhan, Elvan; Varli, Yusuf

    2014-11-01

    The correlation in time series has received considerable attention in the literature. Its use has attained an important role in the social sciences and finance. For example, pair trading in finance is concerned with the correlation between stock prices, returns, etc. In general, Pearson’s correlation coefficient is employed in these areas although it has many underlying assumptions which restrict its use. Here, we introduce a new correlation coefficient which takes into account the lag difference of data points. We investigate the properties of this new correlation coefficient. We demonstrate that it is more appropriate for showing the direction of the covariation of the two variables over time. We also compare the performance of the new correlation coefficient with Pearson’s correlation coefficient and Detrended Cross-Correlation Analysis (DCCA) via simulated examples.

  7. Determination of absolute internal conversion coefficients using the SAGE spectrometer

    NASA Astrophysics Data System (ADS)

    Sorri, J.; Greenlees, P. T.; Papadakis, P.; Konki, J.; Cox, D. M.; Auranen, K.; Partanen, J.; Sandzelius, M.; Pakarinen, J.; Rahkila, P.; Uusitalo, J.; Herzberg, R.-D.; Smallcombe, J.; Davies, P. J.; Barton, C. J.; Jenkins, D. G.

    2016-03-01

    A non-reference based method to determine internal conversion coefficients using the SAGE spectrometer is carried out for transitions in the nuclei of 154Sm, 152Sm and 166Yb. The Normalised-Peak-to-Gamma method is in general an efficient tool to extract internal conversion coefficients. However, in many cases the required well-known reference transitions are not available. The data analysis steps required to determine absolute internal conversion coefficients with the SAGE spectrometer are presented. In addition, several background suppression methods are introduced and an example of how ancillary detectors can be used to select specific reaction products is given. The results obtained for ground-state band E2 transitions show that the absolute internal conversion coefficients can be extracted using the methods described with a reasonable accuracy. In some cases of less intense transitions only an upper limit for the internal conversion coefficient could be given.

  8. Elastic-stiffness mapping by resonance-ultrasound microscopy with isolated piezoelectric oscillator

    NASA Astrophysics Data System (ADS)

    Ogi, Hirotsugu; Tian, Jiayong; Tada, Toyokazu; Hirao, Masahiko

    2003-07-01

    A resonance-ultrasound microscopy has been developed for mapping a material's elastic constant in a localized surface region. It detects the effective elastic modulus through a resonance frequency of free vibrations of a solid probe touching the specimen via a small tungsten-carbide bearing. Langasite (La3Ga5SiO14) crystal is used as a probe because of the low sensitivity of its elastic constants to temperature and its high piezoelectric coefficients. The vibration of the probe is excited and detected with a surrounding solenoid coil. This noncontacting acoustic coupling isolates the probe vibration and measures the resonance frequency with an accuracy better than one part in 105. This microscopic method is applied to a composite material consisting of silicon-carbide (SiC) fibers in titanium-alloy matrix. The stiffness distribution inside a single fiber was determined.

  9. Computational methods for the identification of spatially varying stiffness and damping in beams

    NASA Technical Reports Server (NTRS)

    Banks, H. T.; Rosen, I. G.

    1986-01-01

    A numerical approximation scheme for the estimation of functional parameters in Euler-Bernoulli models for the transverse vibration of flexible beams with tip bodies is developed. The method permits the identification of spatially varying flexural stiffness and Voigt-Kelvin viscoelastic damping coefficients which appear in the hybrid system of ordinary and partial differential equations and boundary conditions describing the dynamics of such structures. An inverse problem is formulated as a least squares fit to data subject to constraints in the form of a vector system of abstract first order evolution equations. Spline-based finite element approximations are used to finite dimensionalize the problem. Theoretical convergence results are given and numerical studies carried out on both conventional (serial) and vector computers are discussed.

  10. Dynamically tuned magnetostrictive spring with electrically controlled stiffness

    NASA Astrophysics Data System (ADS)

    Scheidler, Justin J.; Asnani, Vivake M.; Dapino, Marcelo J.

    2016-03-01

    This paper presents the design and testing of an electrically controllable magnetostrictive spring that has a dynamically tunable stiffness (i.e., a magnetostrictive Varispring). The device enables in situ stiffness tuning or stiffness switching for vibration control applications. Using a nonlinear electromechanical transducer model and an analytical solution of linear, mechanically induced magnetic diffusion, Terfenol-D is shown to have a faster rise time to stepped voltage inputs and a significantly higher magnetic diffusion cut-off frequency relative to Galfenol. A Varispring is manufactured using a laminated Terfenol-D rod. Further rise time reductions are achieved by minimizing the rod’s diameter and winding the electromagnet with larger wire. Dynamic tuning of the Varispring’s stiffness is investigated by measuring the Terfenol-D rod’s strain response to dynamic, compressive, axial forces in the presence of sinusoidal or square wave control currents. The Varispring’s rise time is \\lt 1 ms for 1 A current switches. Continuous modulus changes up to 21.9 GPa and 500 Hz and square wave modulus changes (dynamic {{Δ }}E effect) up to 12.3 GPa and 100 Hz are observed. Stiffness tunability and tuning bandwidth can be considerably increased by operating about a more optimal bias stress and improving the control of the electrical input.

  11. Relationship between ankle stiffness structure and muscle activation.

    PubMed

    Lee, Hyunglae; Wang, Shuo; Hogan, Neville

    2012-01-01

    This paper presents a characterization of the structure of ankle stiffness under multiple levels of muscle activation and the relationship between them. A multi-variable impedance estimation method using a wearable ankle robot enabled clear identification of ankle stiffness structure in the space consisting of the sagittal and frontal planes. With visual feedback showing current and target muscle activation levels, all subjects could successfully maintain multiple target levels (5%∼30% of the maximum voluntary contraction level). Stiffness increased with muscle activation, but the increase was more pronounced in the dorsiflexion-plantarflexion direction than in the inversion-eversion direction, which resulted in a characteristic "peanut" shape. The relation between measured muscle activation level and ankle stiffness was evaluated. All subjects showed a highly linear relation not only for the two principal axis directions of the ankle, i.e., dorsiflexion-plantarflexion and inversion-eversion, but also for the average stiffness value of all directions. These major findings were consistent both for the tibialis anterior and triceps surae activation.

  12. Stiffness Feedback for Myoelectric Forearm Prostheses Using Vibrotactile Stimulation.

    PubMed

    Witteveen, Heidi J B; Luft, Frauke; Rietman, Johan S; Veltink, Peter H

    2014-01-01

    The ability to distinguish object stiffness is a very important aspect in object handling, but completely lacking in current myoelectric prostheses. In human hands both tactile and proprioceptive sensory information are required for stiffness determination. Therefore, it was investigated whether it is possible to distinguish object stiffness with vibrotactile feedback of hand opening and grasping force. Three configurations consisting of an array of coin motors and a single miniature vibrotactile transducer were investigated. Ten healthy subjects and seven subjects with upper limb loss due to amputation or congenital defects performed virtual grasping tasks, in which they controlled hand opening and grasping force. They were asked to determine the stiffness of a grasped virtual object from four options. With hand opening feedback alone or in combination with grasping force feedback, correct stiffness determination was achieved in around 60% of the cases and significantly higher than the 25% achieved without feedback or grasping force feedback alone. Despite the equal performance results, the combination of hand opening and grasping force feedback was preferred by the subjects over the hand opening feedback alone. No differences between feedback configurations and between subjects with upper limb loss and healthy subjects were found.

  13. Severity of Osteoarthritis Is Associated with Increased Arterial Stiffness

    PubMed Central

    Kals, Jaak; Zilmer, Mihkel; Paapstel, Kaido; Märtson, Aare

    2016-01-01

    Objective. Osteoarthritis (OA) is associated with increased cardiovascular comorbidity and mortality. Evidence is lacking about whether arterial stiffness is involved in OA. The objective of our study was to find out associations between OA, arterial stiffness, and adipokines. Design. Seventy end-stage knee and hip OA patients (age 62 ± 7 years) and 70 asymptomatic controls (age 60 ± 7 years) were investigated using the applanation tonometry to determine their parameters of arterial stiffness. Serum adiponectin, leptin, and matrix metalloproteinase 3 (MMP-3) levels were determined using the ELISA method. Correlation between variables was determined using Spearman's rho. Multiple regression analysis with a stepwise selection procedure was employed. Results. Radiographic OA grade was positively associated with increased carotid-femoral pulse wave velocity (cf-PWV) (r = 0.272, p = 0.023). We found that OA grade was also associated with leptin and MMP-3 levels (rho = −0.246, p = 0.040 and rho = 0.235, p = 0.050, resp.). In addition, serum adiponectin level was positively associated with augmentation index and inversely with large artery elasticity index (rho = 0.293, p = 0.006 and rho = −0.249, p = 0.003, resp.). Conclusions. Our results suggest that OA severity is independently associated with increased arterial stiffness and is correlated with expression of adipokines. Thus, increased arterial stiffness and adipokines might play an important role in elevated cardiovascular risk in end-stage OA. PMID:27493667

  14. NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms?

    PubMed Central

    Villela-Nogueira, Cristiane A.; Leite, Nathalie C.; Cardoso, Claudia R. L.; Salles, Gil F.

    2016-01-01

    Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide. Liver inflammation and fibrosis related to NAFLD contribute to disease progression and increasing liver-related mortality and morbidity. Increasing data suggest that NAFLD may be linked to atherosclerotic vascular disease independent of other established cardiovascular risk factors. Central arterial stiffness has been recognized as a measure of cumulative cardiovascular risk marker load, and the measure of carotid-femoral pulse wave velocity (cf-PWV) is regarded as the gold standard assessment of aortic stiffness. It has been shown that increased aortic stiffness predicts cardiovascular morbidity and mortality in several clinical settings, including type 2 diabetes mellitus, a well-known condition associated with advanced stages of NAFLD. Furthermore, recently-published studies reported a strong association between NAFLD and increased arterial stiffness, suggesting a possible link in the pathogenesis of atherosclerosis and NAFLD. We sought to review the published data on the associations between NAFLD and aortic stiffness, in order to better understand the interplay between these two conditions and identify possible common physiopathological mechanisms. PMID:27104526

  15. Arterial Stiffness: A Novel Risk Factor for Kidney Injury Progression?

    PubMed

    Georgianos, Panagiotis I; Sarafidis, Pantelis A; Liakopoulos, Vassilios

    2015-08-01

    Arterial stiffness is typical feature of vascular remodeling in chronic kidney disease (CKD). Increased arterial stiffness raises flow and pressure pulsatility and is considered the principle pathogenic mechanism of isolated systolic hypertension, left ventricular hypertrophy, and congestive heart failure. Apart from the impact of arterial stiffness on left ventricular afterload, downstream transmission of pressure pulsatility to the level of microcirculation is suggested to promote injury of other susceptible organs. This may be of particular importance for kidney injury progression, since passive renal perfusion along with low resistance and input impedance in renal microvessels make kidneys particularly vulnerable to the damaging effect of systemic pulsatile pressure. Recent studies have provided evidence that arterial stiffness culminates in elevated pulsatility and resistance in renal microvasculature, promoting structural damage of small intra-renal arterioles. Further, prospective observational studies have shown that reduced aortic compliance is closely associated with the annual rate of renal function decline and represents independent predictor of kidney injury progression to end-stage renal disease among patients with CKD. This article provides insights into the cross-talk between macrocirculation and renal microcirculation and summarizes the currently available clinical evidence linking increased arterial stiffness with kidney disease progression.

  16. Variable stiffness material and structural concepts for morphing applications

    NASA Astrophysics Data System (ADS)

    Kuder, Izabela K.; Arrieta, Andres F.; Raither, Wolfram E.; Ermanni, Paolo

    2013-11-01

    Morphing, understood as the ability to undergo pronounced shape adaptations to optimally respond to a diversity of operational conditions, has been singled out as a future direction in the pursuit of maximised efficiency of lightweight structures. Whereas a certain degree of adaptivity can be accomplished conventionally by means of mechanical systems, compliance allowing for substantial reversible deformability exhibits far more potential as a morphing strategy. A promising solution to the inherent contradiction between high stiffness and reversible deformation capacity posed by morphing is offered by introducing variable stiffness components. This notion indicates the provision of a controllable range of deformation resistance levels in place of fixed properties, as required by real-time shape adaptation dictated by maximum efficiency under changing external conditions. With special emphasis on the morphing context, the current review aims to identify the main tendencies, undertaking a systematic classification of existing approaches involving stiffness variability. Four broad categories in which variable stiffness has been applied to morphing are therefore distinguished and detailed: material engineering, active mechanical design, semi-active techniques and elastic structural behaviour. Adopting a wide perspective, the study highlights key capabilities, limitations and challenges. The need for attention directed to the variable stiffness strategy is recognised and the significance of intensive research activities in a highly integrated and multidisciplinary environment emphasised if higher maturity stages of the concepts are to be reached. Finally, the potential of emerging directions of semi-active design involving electro-bonded laminates and multi-stable structures is brought into focus.

  17. Variable stiffness sandwich panels using electrostatic interlocking core

    NASA Astrophysics Data System (ADS)

    Heath, Callum J. C.; Bond, Ian P.; Potter, Kevin D.

    2016-04-01

    Structural topology has a large impact on the flexural stiffness of a beam structure. Reversible attachment between discrete substructures allows for control of shear stress transfer between structural elements, thus stiffness modulation. Electrostatic adhesion has shown promise for providing a reversible latching mechanism for controllable internal connectivity. Building on previous research, a thin film copper polyimide laminate has been used to incorporate high voltage electrodes to Fibre Reinforced Polymer (FRP) sandwich structures. The level of electrostatic holding force across the electrode interface is key to the achievable level of stiffness modulation. The use of non-flat interlocking core structures can allow for a significant increase in electrode contact area for a given core geometry, thus a greater electrostatic holding force. Interlocking core geometries based on cosine waves can be Computer Numerical Control (CNC) machined from Rohacell IGF 110 Foam core. These Interlocking Core structures could allow for enhanced variable stiffness functionality compared to basic planar electrodes. This novel concept could open up potential new applications for electrostatically induced variable stiffness structures.

  18. Quantification of plaque stiffness by Brillouin microscopy (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Antonacci, Giuseppe; Pedrigi, Ryan; Krams, Rob; Török, Peter

    2016-03-01

    Spontaneous Brillouin scattering is an inelastic scattering process arising from inherent thermal density fluctuations, or acoustic phonons, propagating in a medium. Over the last few years, Brillouin spectroscopy has shown great potential to become a reliable non-invasive diagnostic tool due to its unique capability of retrieving viscoelastic properties of materials such as strain and stiffness. The detection of the weak scattered light, in addition to the resolution of the Brillouin peaks (typically shifted by few GHz from the central peak) represent one of the greatest challenges in Brillouin. The recent development of high sensitivity CCD cameras has brought Brillouin spectroscopy from a point sampling technique to a new imaging modality. Furthermore, the application of Virtually Imaged Phased Array (VIPA) etalons has dramatically reduced insertion loss simultaneously allowing fast (<1s) collection of the entire spectrum. Hitherto Brillouin microscopy has been shown the ability to provide unique stiffness maps of biological samples, such as the human lens, in a non-destructive manner. In this work, we present results obtained using our Brillouin microscope to map the stiffness variations in the walls of blood vessels in particular when atherosclerotic plaques are formed. The stiffness of the membrane that covers the plaques is critical in developing acute myocardial infarction yet it is not currently possible to credibly assess its stiffness due to lack of suitable methods.

  19. Acute Achilles tendinopathy: effect of pain control on leg stiffness.

    PubMed

    Maquirriain, J; Kokalj, A

    2014-03-01

    Tendinopathies are a major cause of disability in the athletic population; the main purpose of the treatment of these injuries is to reduce pain and improve function. The aim of this study was to evaluate the effect of NSAIDs on leg stiffness of patients suffering acute unilateral Achilles tendinopathy. Twenty-eight eligible male athletes (aged 39.1 ± 10.3 y) suffering acute Achilles tendinopathy were treated with etoricoxib (120 mg oral once daily) during 7 days. Pain (100-mm visual analogue scale-VAS), analgesic effect (percentage of 100-mm VAS reduction), and leg stiffness were evaluated pre- and post- anti-inflammatory treatment. Results of this study showed that over the 7-day treatment period, etoricoxib provided significant relief of Achilles tendon pain (VAS) compared to that experienced at baseline: 54.5 ± 21.6 and 24.5 ± 24.8, respectively (p<0.001). Leg stiffness showed a significant improvement after one-week NSAID therapy: LSR 0.89 ± 0.1 vs. 0.97 ± 0.1; (p=0.02). In conclusion, findings of this study demonstrated that patients suffering acute unilateral Achilles tendinopathy increased their leg stiffness of the affected side after oral anti-inflammatory therapy. Effective control of tendon pain in the acute phase of such sports-related injuries may contribute to improve capabilities associated with high performance like leg stiffness. PMID:24583548

  20. Stiffness characterization of corner-filleted flexure hinges

    NASA Astrophysics Data System (ADS)

    Lobontiu, Nicolae; Garcia, Ephrahim; Hardau, Mihail; Bal, Nicolae

    2004-11-01

    The paper formulates the closed-form stiffness equations that can be used to characterize the static, modal, and dynamic behavior of single-axis corner-filleted flexure hinges, which are incorporated into macro/microscale monolithic mechanisms. The derivation is based on Castiliagno's first theorem and the resulting stiffness equations reflect sensitivity to direct- and cross-bending, axial loading, and torsion. Compared to previous analytical work, which assessed the stiffness of flexures by means of compliances, this paper directly gives the stiffness factors that completely define the elastic response of corner-filleted flexure hinges. The method is cost-effective as it requires considerably less calculation steps, compared to either finite element simulation or experimental characterization. Limit calculations demonstrate that the known engineering equations for a constant cross-section flexure are retrieved from those of a corner-filleted flexure hinge when the fillet radius becomes zero. The analytical model results are compared to experimental and finite element data and the errors are less than 8%. Further numerical simulation based on the analytical model highlights the influence of the geometric parameters on the stiffness properties of a corner-filleted flexure hinge.

  1. Effective Viscosity Coefficient of Nanosuspensions

    NASA Astrophysics Data System (ADS)

    Rudyak, V. Ya.; Belkin, A. A.; Egorov, V. V.

    2008-12-01

    Systematic calculations of the effective viscosity coefficient of nanosuspensions have been performed using the molecular dynamics method. It is established that the viscosity of a nanosuspension depends not only on the volume concentration of the nanoparticles but also on their mass and diameter. Differences from Einstein's relation are found even for nanosuspensions with a low particle concentration.

  2. Aerodynamic coefficients and transformation tables

    NASA Technical Reports Server (NTRS)

    Ames, Joseph S

    1918-01-01

    The problem of the transformation of numerical values expressed in one system of units into another set or system of units frequently arises in connection with aerodynamic problems. Report contains aerodynamic coefficients and conversion tables needed to facilitate such transformation. (author)

  3. Integer Solutions of Binomial Coefficients

    ERIC Educational Resources Information Center

    Gilbertson, Nicholas J.

    2016-01-01

    A good formula is like a good story, rich in description, powerful in communication, and eye-opening to readers. The formula presented in this article for determining the coefficients of the binomial expansion of (x + y)n is one such "good read." The beauty of this formula is in its simplicity--both describing a quantitative situation…

  4. Tables of the coefficients A

    NASA Technical Reports Server (NTRS)

    Chandra, N.

    1974-01-01

    Numerical coefficients required to express the angular distribution for the rotationally elastic or inelastic scattering of electrons from a diatomic molecule were tabulated for the case of nitrogen and in the energy range from 0.20 eV to 10.0 eV. Five different rotational states are considered.

  5. Prediction of stream volatilization coefficients

    USGS Publications Warehouse

    Rathbun, Ronald E.

    1990-01-01

    Equations are developed for predicting the liquid-film and gas-film reference-substance parameters for quantifying volatilization of organic solutes from streams. Molecular weight and molecular-diffusion coefficients of the solute are used as correlating parameters. Equations for predicting molecular-diffusion coefficients of organic solutes in water and air are developed, with molecular weight and molal volume as parameters. Mean absolute errors of prediction for diffusion coefficients in water are 9.97% for the molecular-weight equation, 6.45% for the molal-volume equation. The mean absolute error for the diffusion coefficient in air is 5.79% for the molal-volume equation. Molecular weight is not a satisfactory correlating parameter for diffusion in air because two equations are necessary to describe the values in the data set. The best predictive equation for the liquid-film reference-substance parameter has a mean absolute error of 5.74%, with molal volume as the correlating parameter. The best equation for the gas-film parameter has a mean absolute error of 7.80%, with molecular weight as the correlating parameter.

  6. Determinants of the ambulatory arterial stiffness index in 7604 subjects from 6 populations.

    PubMed

    Adiyaman, Ahmet; Dechering, Dirk G; Boggia, José; Li, Yan; Hansen, Tine W; Kikuya, Masahiro; Björklund-Bodegård, Kristina; Richart, Tom; Thijs, Lutgarde; Torp-Pedersen, Christian; Ohkubo, Takayoshi; Dolan, Eamon; Imai, Yutaka; Sandoya, Edgardo; Ibsen, Hans; Wang, Jiguang; Lind, Lars; O'Brien, Eoin; Thien, Theo; Staessen, Jan A

    2008-12-01

    The ambulatory arterial stiffness index (AASI) is derived from 24-hour ambulatory blood pressure recordings. We investigated whether the goodness-of-fit of the AASI regression line in individual subjects (r(2)) impacts on the association of AASI with established determinants of the relation between diastolic and systolic blood pressures. We constructed the International Database on the Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (7604 participants from 6 countries). AASI was unity minus the regression slope of diastolic on systolic blood pressure in individual 24-hour ambulatory recordings. AASI correlated positively with age and 24-hour mean arterial pressure and negatively with body height and 24-hour heart rate. The single correlation coefficients and the mutually adjusted partial regression coefficients of AASI with age, height, 24-hour mean pressure, and 24-hour heart rate increased from the lowest to the highest quartile of r(2). These findings were consistent in dippers and nondippers (night:day ratio of systolic pressure >or=0.90), women and men, and in Europeans, Asians, and South Americans. The cumulative z score for the association of AASI with these determinants of the relation between diastolic and systolic blood pressures increased curvilinearly with r(2), with most of the improvement in the association occurring above the 20th percentile of r(2) (0.36). In conclusion, a better fit of the AASI regression line enhances the statistical power of analyses involving AASI as marker of arterial stiffness. An r(2) value of 0.36 might be a threshold in sensitivity analyses to improve the stratification of cardiovascular risk.

  7. Higher order matrix differential equations with singular coefficient matrices

    SciTech Connect

    Fragkoulis, V. C.; Kougioumtzoglou, I. A.; Pantelous, A. A.; Pirrotta, A.

    2015-03-10

    In this article, the class of higher order linear matrix differential equations with constant coefficient matrices and stochastic process terms is studied. The coefficient of the highest order is considered to be singular; thus, rendering the response determination of such systems in a straightforward manner a difficult task. In this regard, the notion of the generalized inverse of a singular matrix is used for determining response statistics. Further, an application relevant to engineering dynamics problems is included.

  8. Black holes, information, and the universal coefficient theorem

    NASA Astrophysics Data System (ADS)

    Patrascu, Andrei T.

    2016-07-01

    General relativity is based on the diffeomorphism covariant formulation of the laws of physics while quantum mechanics is based on the principle of unitary evolution. In this article, I provide a possible answer to the black hole information paradox by means of homological algebra and pairings generated by the universal coefficient theorem. The unitarity of processes involving black holes is restored by the demanding invariance of the laws of physics to the change of coefficient structures in cohomology.

  9. Unitarity cuts with massive propagators and algebraic expressions for coefficients

    SciTech Connect

    Britto, Ruth; Feng Bo

    2007-05-15

    In the first part of this paper, we extend the d-dimensional unitarity cut method of Anastasiou et al. to cases with massive propagators. We present formulas for integral reduction with which one can obtain coefficients of all pentagon, box, triangle and massive bubble integrals. In the second part of this paper, we present a detailed study of the phase space integration for unitarity cuts. We carry out spinor integration in generality and give algebraic expressions for coefficients, intended for automated evaluation.

  10. Risk assessment of distribution coefficient from 137Cs measurements.

    PubMed

    Külahci, Fatih; Sen, Zekai

    2009-02-01

    Classically distribution coefficient is defined as the ratio of solid total element concentration to surface water total concentration. This coefficient is obtained from the ion measurements in the Keban Dam, Turkey, which supplies water for domestic, irrigation and hydroelectric energy generation purposes. The measurements of 137Cs are carried out in 40 different sites and the general risk formulation and application is achieved for the distribution coefficient. The models are of exponential type and the spatial independence of the data is considered. Various charts are prepared for a set of risk levels as 5%, 10%, 20%, 25%, and 50%.

  11. Kubo Formulas for Second-Order Hydrodynamic Coefficients

    SciTech Connect

    Moore, Guy D.; Sohrabi, Kiyoumars A.

    2011-03-25

    At second order in gradients, conformal relativistic hydrodynamics depends on the viscosity {eta} and on five additional ''second-order'' hydrodynamical coefficients {tau}{sub {Pi}}, {kappa}, {lambda}{sub 1}, {lambda}{sub 2}, and {lambda}{sub 3}. We derive Kubo relations for these coefficients, relating them to equilibrium, fully retarded three-point correlation functions of the stress tensor. We show that the coefficient {lambda}{sub 3} can be evaluated directly by Euclidean means and does not in general vanish.

  12. Morphological Computation of Haptic Perception of a Controllable Stiffness Probe

    PubMed Central

    Sornkarn, Nantachai; Dasgupta, Prokar; Nanayakkara, Thrishantha

    2016-01-01

    When people are asked to palpate a novel soft object to discern its physical properties such as texture, elasticity, and even non-homogeneity, they not only regulate probing behaviors, but also the co-contraction level of antagonistic muscles to control the mechanical impedance of fingers. It is suspected that such behavior tries to enhance haptic perception by regulating the function of mechanoreceptors at different depths of the fingertips and proprioceptive sensors such as tendon and spindle sensors located in muscles. In this paper, we designed and fabricated a novel two-degree of freedom variable stiffness indentation probe to investigate whether the regulation of internal stiffness, indentation, and probe sweeping velocity (PSV) variables affect the accuracy of the depth estimation of stiff inclusions in an artificial silicon phantom using information gain metrics. Our experimental results provide new insights into not only the biological phenomena of haptic perception but also new opportunities to design and control soft robotic probes. PMID:27257814

  13. Morphological Computation of Haptic Perception of a Controllable Stiffness Probe.

    PubMed

    Sornkarn, Nantachai; Dasgupta, Prokar; Nanayakkara, Thrishantha

    2016-01-01

    When people are asked to palpate a novel soft object to discern its physical properties such as texture, elasticity, and even non-homogeneity, they not only regulate probing behaviors, but also the co-contraction level of antagonistic muscles to control the mechanical impedance of fingers. It is suspected that such behavior tries to enhance haptic perception by regulating the function of mechanoreceptors at different depths of the fingertips and proprioceptive sensors such as tendon and spindle sensors located in muscles. In this paper, we designed and fabricated a novel two-degree of freedom variable stiffness indentation probe to investigate whether the regulation of internal stiffness, indentation, and probe sweeping velocity (PSV) variables affect the accuracy of the depth estimation of stiff inclusions in an artificial silicon phantom using information gain metrics. Our experimental results provide new insights into not only the biological phenomena of haptic perception but also new opportunities to design and control soft robotic probes. PMID:27257814

  14. Estimation of Stiffness Parameter on the Common Carotid Artery

    NASA Astrophysics Data System (ADS)

    Koya, Yoshiharu; Mizoshiri, Isao; Matsui, Kiyoaki; Nakamura, Takashi

    The arteriosclerosis is on the increase with an aging or change of our living environment. For that reason, diagnosis of the common carotid artery using echocardiogram is doing to take precautions carebropathy. Up to the present, several methods to measure stiffness parameter of the carotid artery have been proposed. However, they have analyzed at the only one point of common carotid artery. In this paper, we propose the method of analysis extended over a wide area of common carotid artery. In order to measure stiffness parameter of common carotid artery from echocardiogram, it is required to detect two border curves which are boundaries between vessel wall and blood. The method is composed of two steps. The first step is the detection of border curves, and the second step is the calculation of stiffness parameter using diameter of common carotid artery. Experimental results show the validity of the proposed method.

  15. Tissue stiffness dictates development, homeostasis, and disease progression.

    PubMed

    Handorf, Andrew M; Zhou, Yaxian; Halanski, Matthew A; Li, Wan-Ju

    2015-01-01

    Tissue development is orchestrated by the coordinated activities of both chemical and physical regulators. While much attention has been given to the role that chemical regulators play in driving development, researchers have recently begun to elucidate the important role that the mechanical properties of the extracellular environment play. For instance, the stiffness of the extracellular environment has a role in orienting cell division, maintaining tissue boundaries, directing cell migration, and driving differentiation. In addition, extracellular matrix stiffness is important for maintaining normal tissue homeostasis, and when matrix mechanics become imbalanced, disease progression may ensue. In this article, we will review the important role that matrix stiffness plays in dictating cell behavior during development, tissue homeostasis, and disease progression.

  16. Tailoring shear-stiff, mica-like nanoplatelets.

    PubMed

    Möller, Michael W; Handge, Ulrich A; Kunz, Daniel A; Lunkenbein, Thomas; Altstädt, Volker; Breu, Josef

    2010-02-23

    This work introduces a novel facile method to produce shear-stiff, mica-like nanoplatelets by efficient exfoliation. The essence of this procedure is the nonreversible alteration of the interlamellar reactivity of a synthetic fluorohectorite by simple cation exchange. The possibility of switching from highly hydrated to collapsed interlayers permits a highly efficient exfoliation in the swollen state while providing shear-stiffness in the collapsed state. This method restricts cation exchange in the mica-like nanoplatelets to the outer surfaces, which represents a significant advantage for use in nanocomposites as compared to conventional organoclays which contain up to 40%/wt of organocations. It is expected that this new type of rigid, shear-stiff, clay-based nanoplatelets will be superior for reinforcement when used in composite materials like polymer layered silicate nanocomposites or artificial nacre. PMID:20088599

  17. Stiffness of the Extrafibrillar Phase in Staggered Biological Arrays

    NASA Astrophysics Data System (ADS)

    Bar-On, Benny; Wagner, H. Daniel

    2012-08-01

    A number of important biological tissues such as nacre, tendon, and bone consist of staggered structural arrays as universal motifs. Such arrays usually include stiff fibril-like (or plateletlike, or needlelike) elements embedded in an extrafibrillar (XF) phase. This work discusses the effect of the stiffness of such an XF matrix on the elastic properties of the resulting staggered composite. In the case of most biological composites, this XF stiffness is hardly accessible and very little data are available. We develop an analysis based on previous analytical formulation that results in a relation between the XF modulus and the deformations of the staggered particles. This analysis is then used to back-calculate the yet unmeasured modulus of the XF phase from experimental deformation data, thereby providing a simple alternative to potentially complex direct measurements. This is demonstrated and validated for parallel-fiber bone tissue.

  18. Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression

    PubMed Central

    Handorf, Andrew M; Zhou, Yaxian; Halanski, Matthew A; Li, Wan-Ju

    2015-01-01

    Abstract Tissue development is orchestrated by the coordinated activities of both chemical and physical regulators. While much attention has been given to the role that chemical regulators play in driving development, researchers have recently begun to elucidate the important role that the mechanical properties of the extracellular environment play. For instance, the stiffness of the extracellular environment has a role in orienting cell division, maintaining tissue boundaries, directing cell migration, and driving differentiation. In addition, extracellular matrix stiffness is important for maintaining normal tissue homeostasis, and when matrix mechanics become imbalanced, disease progression may ensue. In this article, we will review the important role that matrix stiffness plays in dictating cell behavior during development, tissue homeostasis, and disease progression. PMID:25915734

  19. Stiffness of the extrafibrillar phase in staggered biological arrays.

    PubMed

    Bar-On, Benny; Wagner, H Daniel

    2012-08-17

    A number of important biological tissues such as nacre, tendon, and bone consist of staggered structural arrays as universal motifs. Such arrays usually include stiff fibril-like (or plateletlike, or needlelike) elements embedded in an extrafibrillar (XF) phase. This work discusses the effect of the stiffness of such an XF matrix on the elastic properties of the resulting staggered composite. In the case of most biological composites, this XF stiffness is hardly accessible and very little data are available. We develop an analysis based on previous analytical formulation that results in a relation between the XF modulus and the deformations of the staggered particles. This analysis is then used to back-calculate the yet unmeasured modulus of the XF phase from experimental deformation data, thereby providing a simple alternative to potentially complex direct measurements. This is demonstrated and validated for parallel-fiber bone tissue. PMID:23006404

  20. Binary-YORP Coefficients for Known Asteroid Shapes

    NASA Astrophysics Data System (ADS)

    McMahon, Jay W.; Scheeres, D. J.

    2012-10-01

    The binary YORP (bYORP) effect has been hypothesized to be a significant factor in the evolution of near-Earth binary asteroid systems (Cuk and Burns, Icarus, v.176, pp.418-431, 2005; McMahon and Scheeres, CMDA, v.106, pp.261-300, 2010). However, understanding of the coefficient values for realistic asteroid shapes is lacking due to the small number of shape models available for the generally smaller secondary asteroids. Until now, we have only calculated the coefficients based on the shape of 1999 KW4 Beta, although various studies by other authors have computed coefficients for artificially generated asteroids based on Gaussian Spheres and some shape models without self-shadowing (Steinberg and Sari, The Astronomical Journal, v.141, pp.55-64, 2011). We also scaled the 1999 KW4 Beta coefficients to other binary systems with no knowledge of the other systems' secondary shapes in order to make evolutionary predictions (McMahon and Scheeres, Icarus Vol. 209, pp 494-509, 2010). In this study, we compute the bYORP coefficient for a range of asteroid shapes, using these as a stand-in for actual secondaries. This allows us to circumvent the lack of information on binary asteroid secondaries and to develop a richer database of realistic coefficients. While this approach may miss some key features of binary secondaries, at the least it provides some statistics on the expected variability of the bYORP coefficient. We analyze all available asteroid shape models on the PDS-SBN, including radar-based shape models and models estimated from past spacecraft missions. The coefficients are computed with an updated algorithm that includes the effects of self-shadowing. We also present the coefficients for perturbed versions of the available shape models, which give effective error bars to the computed coefficients due to inexact shape models. Finally, we discuss the dynamical implications of the derived bYORP coefficients on binary asteroid evolution.

  1. IMPACT OF MORNING STIFFNESS, EDUCATION, AND AGE ON THE FUNCTIONAL STATUS OF PATIENTS WITH RHEUMATOID ARTHRITIS.

    PubMed

    Sahatçiu-Meka, Vjollca; Rexhepi, Sylejman; Manxhuka-Kerliu, Suzana; Pallaska, Kelmend; Murtezani, Ardiana; Osmani-Vllasolli, Teuta; Rexhepi, Mjellma; Rexhepi, Blerta

    2015-01-01

    The purpose of this study was to explore the relationship between disability status and duration of morning stiffness in hands with regard to age, level of education, and gender in patients with rheumatoid arthritis (RA). Also, the authors wanted to investigate this relationship with regard to the presence of rheumatoid factor, i.e., the serological status. A retrospective study was conducted in 250 patients with the classic form of RA (186 females, s64 males, mean age Xb = 49.96 y ears, range 25-60 years, disease duration 1-27 years, Xb = 6.41) previously diagnosed with RA according to the ACR (American College of Rheumatology 1987 criteria). All patients were in Steinbrocker functional classes II and III. The probability level was expressed by p < 0.01 and p < 0.05. The relationship between the variables was measured by point-biserial correlation. The correlation between duration of morning stiffness and functional class was positive but low [(r = 0.10, y = 0.00x + 2.37, p > 0.05) seronegative, (r = 0.12, y = 0.00x + 2.30, p > 0.05) seropositive]. High positive values were obtained for the linear correlation coefficient between duration of the disease and functional class (p < 0.01). Also, high values were obtained regarding the coefficient of correlation between age and functional class [(r = 0.29, p < 0.01) seronegative, (r = 0.47, p < 0.01) seropositive]. Uneducated patients were significantly more represented in functional class III [ 23 (50%) seronegative, 19 (42.2%) seropositive] than in functional class II [16 (20.3%) seronegative, 22 (27.5%) seropositive]. In conclusion, in this study of patients with rheumatoid arthritis, increased duration of morning stiffness was associated with functional disability. Functional disability increased with the duration of the disease, depended on age and educational level, and was more pronounced in older age, regardless of RA serological status. With regard to serological status and sex, the differences were non

  2. IMPACT OF MORNING STIFFNESS, EDUCATION, AND AGE ON THE FUNCTIONAL STATUS OF PATIENTS WITH RHEUMATOID ARTHRITIS.

    PubMed

    Sahatçiu-Meka, Vjollca; Rexhepi, Sylejman; Manxhuka-Kerliu, Suzana; Pallaska, Kelmend; Murtezani, Ardiana; Osmani-Vllasolli, Teuta; Rexhepi, Mjellma; Rexhepi, Blerta

    2015-01-01

    The purpose of this study was to explore the relationship between disability status and duration of morning stiffness in hands with regard to age, level of education, and gender in patients with rheumatoid arthritis (RA). Also, the authors wanted to investigate this relationship with regard to the presence of rheumatoid factor, i.e., the serological status. A retrospective study was conducted in 250 patients with the classic form of RA (186 females, s64 males, mean age Xb = 49.96 y ears, range 25-60 years, disease duration 1-27 years, Xb = 6.41) previously diagnosed with RA according to the ACR (American College of Rheumatology 1987 criteria). All patients were in Steinbrocker functional classes II and III. The probability level was expressed by p < 0.01 and p < 0.05. The relationship between the variables was measured by point-biserial correlation. The correlation between duration of morning stiffness and functional class was positive but low [(r = 0.10, y = 0.00x + 2.37, p > 0.05) seronegative, (r = 0.12, y = 0.00x + 2.30, p > 0.05) seropositive]. High positive values were obtained for the linear correlation coefficient between duration of the disease and functional class (p < 0.01). Also, high values were obtained regarding the coefficient of correlation between age and functional class [(r = 0.29, p < 0.01) seronegative, (r = 0.47, p < 0.01) seropositive]. Uneducated patients were significantly more represented in functional class III [ 23 (50%) seronegative, 19 (42.2%) seropositive] than in functional class II [16 (20.3%) seronegative, 22 (27.5%) seropositive]. In conclusion, in this study of patients with rheumatoid arthritis, increased duration of morning stiffness was associated with functional disability. Functional disability increased with the duration of the disease, depended on age and educational level, and was more pronounced in older age, regardless of RA serological status. With regard to serological status and sex, the differences were non-significant.

  3. Stiff skin syndrome versus scleroderma: a report of two cases.

    PubMed

    Azevedo, V F; Serafini, S Z; Werner, B; Müller, C S; Franchini, C F M; Morais, R L S L

    2009-09-01

    Stiff skin syndrome is a rare cutaneous disease, scleroderma-like disorder that presents in infancy or early childhood with rock-hard skin, limited joint mobility, and mild hypertrichosis. Normally, it occurs in the absence of visceral or muscle involvement. Patients do not present immunologic abnormalities or vascular hyperactivity. We describe two adults who initially were diagnosed suffering from scleroderma but fit criteria for stiff skin syndrome. A review of the clinical range of this disorder and discussion of the differential diagnosis with scleroderma is presented. PMID:19415378

  4. Effect of Hybridization on Stiffness Properties of Woven Textile Composites

    NASA Astrophysics Data System (ADS)

    Bejan, Liliana; Taranu, Nicolae; Sîrbu, Adriana

    2013-04-01

    The present study focuses on stiffness properties of woven textile reinforced polymeric composites with respect to hybridization, and geometry of reinforcement. The analyzed composites represent combinations of different fibre materials (E-glass, Kevlar 49, carbon HM) in a predetermined fabric geometry (a plane weave embedded in thermosetting polymeric resin) serving controlled properties and required performance. The effects of hybridization on the stiffness properties of woven textile composites have been studied with respect to the fibres materials, the unbalancing degree of fabrics, and the variation of compactness and undulation of yarns. Some undesirable effects in fabric geometry can be overcome by the combined effects of hybridization and compactness.

  5. Further understanding of Huygens’ coupled clocks: The effect of stiffness

    NASA Astrophysics Data System (ADS)

    Peña Ramirez, J.; Aihara, K.; Fey, R. H. B.; Nijmeijer, H.

    2014-03-01

    A simplified model of the classical Huygens’ experiment on synchronization of pendulum clocks is examined. The model consists of two pendula coupled by an elastically supported rigid bar. The synchronized limit behaviour of the system, i.e. in-phase and anti-phase synchronization of the pendula, is studied as a function of the stiffness of the spring that supports the coupling bar. It is demonstrated that the stiffness has a large influence on the existence, stability, and oscillation frequency of the in-phase solution. The relationship between the obtained results and experimental results that have been reported in the literature, including Huygens’ original observations, is stressed.

  6. Experimental measurement of the stiffness of the cupula.

    PubMed

    Grant, J W; Van Buskirk, W C

    1976-06-01

    An experimental procedure is described which consists of cutting the canal duct, inserting a micropipette and administering known volumetric displacements to the cupula. The cupula is made visible by dying the endolymph. Known displacements are administered to the cupula, and the time constant of the return to its equilibrium position is measured. With this information, the stiffness of the cupula is calculated. The experiment was successfully carried out on five White King pigeons. The mean stiffness found in somewhat less than other results reported in the literature, and reasons for this discrepancy are noted.

  7. Diagnosis and clinical assessment of a stiff shoulder

    PubMed Central

    2015-01-01

    The assessment of a stiff shoulder is explored, the necessary investigations to reach a diagnosis are discussed, and the likely causes that can contribute to a frozen shoulder are described. Two flow diagrams are included to help in reaching a conclusion when seeing a patient with a stiff shoulder. The key elements to reaching that conclusion are: carefully listening to the patients story, noting whether there has been a history of trauma, as well as a careful and thorough examination and a plain X-ray with two views. PMID:27582968

  8. Dynamic Estimation of Environmental Stiffness by Bilateral Control

    NASA Astrophysics Data System (ADS)

    Takei, Takayoshi; Shimono, Tomoyuki; Ohnishi, Kouhei

    Recently, minimally invasive surgery (MIS) has become apparent. Research has been performed on surgical robots needed in MIS. In the case of MIS, it is effective to express environmental impedance as numerical data in order to preserve it for establishing standard reference values of the conditions of internal organs. In this paper, we propose a novel method for the estimation of stiffness in real environments in which bilaterally controlled robots are needed. By using the proposed method, environmental stiffness can be estimated dynamically regardless of the initial position of slave system. The viability of the proposed method is confirmed from the experimental results.

  9. Stochastic partial differential equations with unbounded and degenerate coefficients

    NASA Astrophysics Data System (ADS)

    Zhang, Xicheng

    In this article, using DiPerna-Lions theory (DiPerna and Lions, 1989) [1], we investigate linear second order stochastic partial differential equations with unbounded and degenerate non-smooth coefficients, and obtain several conditions for existence and uniqueness. Moreover, we also prove the L-integrability and a general maximal principle for generalized solutions of SPDEs. As applications, we study nonlinear filtering problem and also obtain the existence and uniqueness of generalized solutions for a degenerate nonlinear SPDE.

  10. Influence of measurement depth on the stiffness assessment of healthy liver with real-time shear wave elastography.

    PubMed

    Wang, Cong-Zhi; Zheng, Jian; Huang, Ze-Ping; Xiao, Yang; Song, Dan; Zeng, Jie; Zheng, Hai-Rong; Zheng, Rong-Qin

    2014-03-01

    The purpose of this study was to determine the measurement depth range within which liver stiffness can be reliably assessed using real-time shear wave elastography (SWE) technology. Measurements were performed on phantoms and healthy volunteers. In the first group of patients, measurements were performed at depths of 2-8 cm from the probe surface. In the second group of patients, measurements were conducted 0-7 cm below the liver capsule. Success rate of measurements (SRoM), success rate of patients (SRoS) and coefficients of variation (CVs) of repeated measurements were compared. The SRoMs at 3-7 cm and the CVs at 2-5 cm from the probe surface were significantly higher and lower than those at other depths (p < 0.001), respectively. SRoS was zero 0-1 cm below the liver capsule. Furthermore, the features of 2-D stiffness mapping images were also found to change with depth. According to our results, the depth range for the most reliable liver stiffness assessment using SWE should be 3-5 cm from the probe surface and simultaneously 1-2 cm below the liver capsule.

  11. Estimation of deformation and stiffness of fractures close to tunnels using data from single-hole hydraulic testing and grouting

    SciTech Connect

    Fransson, A.; Tsang, C.-F.; Rutqvist, J.; Gustafson, G.

    2010-05-01

    Sealing of tunnels in fractured rocks is commonly performed by pre- or post-excavation grouting. The grouting boreholes are frequently drilled close to the tunnel wall, an area where rock stresses can be low and fractures can more easily open up during grout pressurization. In this paper we suggest that data from hydraulic testing and grouting can be used to identify grout-induced fracture opening, to estimate fracture stiffness of such fractures, and to evaluate its impact on the grout performance. A conceptual model and a method are presented for estimating fracture stiffness. The method is demonstrated using grouting data from four pre-excavation grouting boreholes at a shallow tunnel (50 m) in Nygard, Sweden, and two post-excavation grouting boreholes at a deep tunnel (450 m) in Aespoe HRL, Sweden. The estimated stiffness of intersecting fractures for the boreholes at the shallow Nygard tunnel are low (2-5 GPa/m) and in agreement with literature data from field experiments at other fractured rock sites. Higher stiffness was obtained for the deeper tunnel boreholes at Aespoe which is reasonable considering that generally higher rock stresses are expected at greater depths. Our method of identifying and evaluating the properties and impact of deforming fractures might be most applicable when grouting takes place in boreholes adjacent to the tunnel wall, where local stresses might be low and where deforming (opening) fractures may take most of the grout.

  12. Study of Dispersion Coefficient Channel

    NASA Astrophysics Data System (ADS)

    Akiyama, K. R.; Bressan, C. K.; Pires, M. S. G.; Canno, L. M.; Ribeiro, L. C. L. J.

    2016-08-01

    The issue of water pollution has worsened in recent times due to releases, intentional or not, of pollutants in natural water bodies. This causes several studies about the distribution of pollutants are carried out. The water quality models have been developed and widely used today as a preventative tool, ie to try to predict what will be the concentration distribution of constituent along a body of water in spatial and temporal scale. To understand and use such models, it is necessary to know some concepts of hydraulic high on their application, including the longitudinal dispersion coefficient. This study aims to conduct a theoretical and experimental study of the channel dispersion coefficient, yielding more information about their direct determination in the literature.

  13. Consistent transport coefficients in astrophysics

    NASA Technical Reports Server (NTRS)

    Fontenla, Juan M.; Rovira, M.; Ferrofontan, C.

    1986-01-01

    A consistent theory for dealing with transport phenomena in stellar atmospheres starting with the kinetic equations and introducing three cases (LTE, partial LTE, and non-LTE) was developed. The consistent hydrodynamical equations were presented for partial-LTE, the transport coefficients defined, and a method shown to calculate them. The method is based on the numerical solution of kinetic equations considering Landau, Boltzmann, and Focker-Planck collision terms. Finally a set of results for the transport coefficients derived for a partially ionized hydrogen gas with radiation was shown, considering ionization and recombination as well as elastic collisions. The results obtained imply major changes is some types of theoretical model calculations and can resolve some important current problems concerning energy and mass balance in the solar atmosphere. It is shown that energy balance in the lower solar transition region can be fully explained by means of radiation losses and conductive flux.

  14. High temperature Seebeck coefficient metrology

    SciTech Connect

    Martin, J.; Tritt, T.; Uher, C.

    2010-12-15

    We present an overview of the challenges and practices of thermoelectric metrology on bulk materials at high temperature (300 to 1300 K). The Seebeck coefficient, when combined with thermal and electrical conductivity, is an essential property measurement for evaluating the potential performance of novel thermoelectric materials. However, there is some question as to which measurement technique(s) provides the most accurate determination of the Seebeck coefficient at high temperature. This has led to the implementation of nonideal practices that have further complicated the confirmation of reported high ZT materials. To ensure meaningful interlaboratory comparison of data, thermoelectric measurements must be reliable, accurate, and consistent. This article will summarize and compare the relevant measurement techniques and apparatus designs required to effectively manage uncertainty, while also providing a reference resource of previous advances in high temperature thermoelectric metrology.

  15. Portable vapor diffusion coefficient meter

    DOEpatents

    Ho, Clifford K.

    2007-06-12

    An apparatus for measuring the effective vapor diffusion coefficient of a test vapor diffusing through a sample of porous media contained within a test chamber. A chemical sensor measures the time-varying concentration of vapor that has diffused a known distance through the porous media. A data processor contained within the apparatus compares the measured sensor data with analytical predictions of the response curve based on the transient diffusion equation using Fick's Law, iterating on the choice of an effective vapor diffusion coefficient until the difference between the predicted and measured curves is minimized. Optionally, a purge fluid can forced through the porous media, permitting the apparatus to also measure a gas-phase permeability. The apparatus can be made lightweight, self-powered, and portable for use in the field.

  16. Special functions associated with SU(3) Wigner-Clebsch-Gordan coefficients

    SciTech Connect

    Louck, J.D.; Biedenharn, L.C.

    1990-01-01

    The Wigner-Clebsch-Gordan (WCG) coefficients of the unitary groups are a rich source of multivariable special functions. The general algebraic setting of these coefficients is reviewed and several special functions associated with the SU(3) WCG coefficients defined and their properties presented. 29 refs.

  17. The interpretation of selection coefficients.

    PubMed

    Barton, N H; Servedio, M R

    2015-05-01

    Evolutionary biologists have an array of powerful theoretical techniques that can accurately predict changes in the genetic composition of populations. Changes in gene frequencies and genetic associations between loci can be tracked as they respond to a wide variety of evolutionary forces. However, it is often less clear how to decompose these various forces into components that accurately reflect the underlying biology. Here, we present several issues that arise in the definition and interpretation of selection and selection coefficients, focusing on insights gained through the examination of selection coefficients in multilocus notation. Using this notation, we discuss how its flexibility-which allows different biological units to be identified as targets of selection-is reflected in the interpretation of the coefficients that the notation generates. In many situations, it can be difficult to agree on whether loci can be considered to be under "direct" versus "indirect" selection, or to quantify this selection. We present arguments for what the terms direct and indirect selection might best encompass, considering a range of issues, from viability and sexual selection to kin selection. We show how multilocus notation can discriminate between direct and indirect selection, and describe when it can do so. PMID:25790030

  18. Stiffness of sphere-plate contacts at MHz frequencies: dependence on normal load, oscillation amplitude, and ambient medium.

    PubMed

    Vlachová, Jana; König, Rebekka; Johannsmann, Diethelm

    2015-01-01

    The stiffness of micron-sized sphere-plate contacts was studied by employing high frequency, tangential excitation of variable amplitude (0-20 nm). The contacts were established between glass spheres and the surface of a quartz crystal microbalance (QCM), where the resonator surface had been coated with either sputtered SiO2 or a spin-cast layer of poly(methyl methacrylate) (PMMA). The results from experiments undertaken in the dry state and in water are compared. Building on the shifts in the resonance frequency and resonance bandwidth, the instrument determines the real and the imaginary part of the contact stiffness, where the imaginary part quantifies dissipative processes. The method is closely analogous to related procedures in AFM-based metrology. The real part of the contact stiffness as a function of normal load can be fitted with the Johnson-Kendall-Roberts (JKR) model. The contact stiffness was found to increase in the presence of liquid water. This finding is tentatively explained by the rocking motion of the spheres, which couples to a squeeze flow of the water close to the contact. The loss tangent of the contact stiffness is on the order of 0.1, where the energy losses are associated with interfacial processes. At high amplitudes partial slip was found to occur. The apparent contact stiffness at large amplitude depends linearly on the amplitude, as predicted by the Cattaneo-Mindlin model. This finding is remarkable insofar, as the Cattaneo-Mindlin model assumes Coulomb friction inside the sliding region. Coulomb friction is typically viewed as a macroscopic concept, related to surface roughness. An alternative model (formulated by Savkoor), which assumes a constant frictional stress in the sliding zone independent of the normal pressure, is inconsistent with the experimental data. The apparent friction coefficients slightly increase with normal force, which can be explained by nanoroughness. In other words, contact splitting (i.e., a transport of

  19. Arterial stiffness as a risk factor for coronary artery disease.

    PubMed

    Liao, Josh; Farmer, John

    2014-02-01

    Hypertension is a major modifiable risk factor, and clinical trials have demonstrated that successful reduction of elevated blood pressure to target levels translates into decreased risk for the development of coronary artery disease, stroke, heart failure, and renal failure. The arterial system had previously been regarded as a passive conduit for the transportation of arterial blood to peripheral tissues. The physiologic role the arterial system was greatly expanded by the recognition of the central role of the endothelial function in a variety of physiologic processes. The role of arterial function and structure in cardiovascular physiology was expanded with the development of a variety of parameters that evaluate arterial stiffness. Markers of arterial stiffness have been correlated with cardiovascular outcomes, and have been classified as an emerging risk factor that provides prognostic information beyond standard stratification strategies involving hypertension, diabetes, obesity, dyslipidemia and smoking. Multiple epidemiologic studies have correlated markers of arterial stiffness such as pulse-wave velocity, augmentation index and pulse pressure with risk for the development of fatal and nonfatal cardiovascular events. Additionally, measurements of arterial stiffness had clarified the results of clinical trials that demonstrated differing impacts on clinical outcomes, despite similar reductions in blood pressure, as measured by brachial and sphygmomanometry.

  20. Flexural stiffness of feather shafts: geometry rules over material properties.

    PubMed

    Bachmann, Thomas; Emmerlich, Jens; Baumgartner, Werner; Schneider, Jochen M; Wagner, Hermann

    2012-02-01

    Flight feathers of birds interact with the flow field during flight. They bend and twist under aerodynamic loads. Two parameters are mainly responsible for flexibility in feathers: the elastic modulus (Young's modulus, E) of the material (keratin) and the geometry of the rachises, more precisely the second moment of area (I). Two independent methods were employed to determine Young's modulus of feather rachis keratin. Moreover, the second moment of area and the bending stiffness of feather shafts from fifth primaries of barn owls (Tyto alba) and pigeons (Columba livia) were calculated. These species of birds are of comparable body mass but differ in wing size and flight style. Whether their feather material (keratin) underwent an adaptation in stiffness was previously unknown. This study shows that no significant variation in Young's modulus between the two species exists. However, differences in Young's modulus between proximal and distal feather regions were found in both species. Cross-sections of pigeon rachises were particularly well developed and rich in structural elements, exemplified by dorsal ridges and a well-pronounced transversal septum. In contrast, cross-sections of barn owl rachises were less profiled but had a higher second moment of area. Consequently, the calculated bending stiffness (EI) was higher in barn owls as well. The results show that flexural stiffness is predominantly influenced by the geometry of the feathers rather than by local material properties. PMID:22246249

  1. Numerical Integration of Elastoviscoplasticity Model with Stiff Hardening and Softening

    SciTech Connect

    Vorobiev, O.Y.; Lomov, I.N; Glenn, L.A.; Rubin, M.B.

    2000-02-01

    The constitutive equations for viscoplasticity typically are stiff differential equations and require special numerical methods to integrate them efficiently. The objective of this paper is to propose a class of rate-dependent viscoplastic constitutive equations which can be integrated by an efficient explicit scheme that includes the first order effect of pressure and plastic strain hardening.

  2. Simultaneously high stiffness and damping in nanoengineered microtruss composites.

    PubMed

    Meaud, Julien; Sain, Trisha; Yeom, Bongjun; Park, Sei Jin; Shoultz, Anna Brieland; Hulbert, Gregory; Ma, Zheng-Dong; Kotov, Nicholas A; Hart, A John; Arruda, Ellen M; Waas, Anthony M

    2014-04-22

    Materials combining high stiffness and mechanical energy dissipation are needed in automotive, aviation, construction, and other technologies where structural elements are exposed to dynamic loads. In this paper we demonstrate that a judicious combination of carbon nanotube engineered trusses held in a dissipative polymer can lead to a composite material that simultaneously exhibits both high stiffness and damping. Indeed, the combination of stiffness and damping that is reported is quite high in any single monolithic material. Carbon nanotube (CNT) microstructures grown in a novel 3D truss topology form the backbone of these nanocomposites. The CNT trusses are coated by ceramics and by a nanostructured polymer film assembled using the layer-by-layer technique. The crevices of the trusses are then filled with soft polyurethane. Each constituent of the composite is accurately modeled, and these models are used to guide the manufacturing process, in particular the choice of the backbone topology and the optimization of the mechanical properties of the constituent materials. The resulting composite exhibits much higher stiffness (80 times) and similar damping (specific damping capacity of 0.8) compared to the polymer. Our work is a step forward in implementing the concept of materials by design across multiple length scales. PMID:24620996

  3. Extracellular Matrix Stiffness and Architecture Govern Intracellular Rheology in Cancer

    PubMed Central

    Baker, Erin L.; Bonnecaze, Roger T.; Zaman, Muhammad H.

    2009-01-01

    Abstract Little is known about the complex interplay between the extracellular mechanical environment and the mechanical properties that characterize the dynamic intracellular environment. To elucidate this relationship in cancer, we probe the intracellular environment using particle-tracking microrheology. In three-dimensional (3D) matrices, intracellular effective creep compliance of prostate cancer cells is shown to increase with increasing extracellular matrix (ECM) stiffness, whereas modulating ECM stiffness does not significantly affect the intracellular mechanical state when cells are attached to two-dimensional (2D) matrices. Switching from 2D to 3D matrices induces an order-of-magnitude shift in intracellular effective creep compliance and apparent elastic modulus. However, for a given matrix stiffness, partial blocking of β1 integrins mitigates the shift in intracellular mechanical state that is invoked by switching from a 2D to 3D matrix architecture. This finding suggests that the increased cell-matrix engagement inherent to a 3D matrix architecture may contribute to differences observed in viscoelastic properties between cells attached to 2D matrices and cells embedded within 3D matrices. In total, our observations show that ECM stiffness and architecture can strongly influence the intracellular mechanical state of cancer cells. PMID:19686648

  4. Extracellular matrix stiffness dictates Wnt expression through integrin pathway.

    PubMed

    Du, Jing; Zu, Yan; Li, Jing; Du, Shuyuan; Xu, Yipu; Zhang, Lang; Jiang, Li; Wang, Zhao; Chien, Shu; Yang, Chun

    2016-02-08

    It is well established that extracellular matrix (ECM) stiffness plays a significant role in regulating the phenotypes and behaviors of many cell types. However, the mechanism underlying the sensing of mechanical cues and subsequent elasticity-triggered pathways remains largely unknown. We observed that stiff ECM significantly enhanced the expression level of several members of the Wnt/β-catenin pathway in both bone marrow mesenchymal stem cells and primary chondrocytes. The activation of β-catenin by stiff ECM is not dependent on Wnt signals but is elevated by the activation of integrin/ focal adhesion kinase (FAK) pathway. The accumulated β-catenin then bound to the wnt1 promoter region to up-regulate the gene transcription, thus constituting a positive feedback of the Wnt/β-catenin pathway. With the amplifying effect of positive feedback, this integrin-activated β-catenin/Wnt pathway plays significant roles in mediating the enhancement of Wnt signal on stiff ECM and contributes to the regulation of mesenchymal stem cell differentiation and primary chondrocyte phenotype maintenance. The present integrin-regulated Wnt1 expression and signaling contributes to the understanding of the molecular mechanisms underlying the regulation of cell behaviors by ECM elasticity.

  5. Extracellular matrix stiffness dictates Wnt expression through integrin pathway

    PubMed Central

    Du, Jing; Zu, Yan; Li, Jing; Du, Shuyuan; Xu, Yipu; Zhang, Lang; Jiang, Li; Wang, Zhao; Chien, Shu; Yang, Chun

    2016-01-01

    It is well established that extracellular matrix (ECM) stiffness plays a significant role in regulating the phenotypes and behaviors of many cell types. However, the mechanism underlying the sensing of mechanical cues and subsequent elasticity-triggered pathways remains largely unknown. We observed that stiff ECM significantly enhanced the expression level of several members of the Wnt/β-catenin pathway in both bone marrow mesenchymal stem cells and primary chondrocytes. The activation of β-catenin by stiff ECM is not dependent on Wnt signals but is elevated by the activation of integrin/ focal adhesion kinase (FAK) pathway. The accumulated β-catenin then bound to the wnt1 promoter region to up-regulate the gene transcription, thus constituting a positive feedback of the Wnt/β-catenin pathway. With the amplifying effect of positive feedback, this integrin-activated β-catenin/Wnt pathway plays significant roles in mediating the enhancement of Wnt signal on stiff ECM and contributes to the regulation of mesenchymal stem cell differentiation and primary chondrocyte phenotype maintenance. The present integrin-regulated Wnt1 expression and signaling contributes to the understanding of the molecular mechanisms underlying the regulation of cell behaviors by ECM elasticity. PMID:26854061

  6. Hydrogen-bond reinforced vanadia nanofiber paper of high stiffness.

    PubMed

    Burghard, Zaklina; Leineweber, Andreas; van Aken, Peter A; Dufaux, Thomas; Burghard, Marko; Bill, Joachim

    2013-05-01

    Low-temperature, solution-based self-assembly of vanadia nanofibers yields a free-standing, ceramic paper with an outstanding combination of high strength, stiffness, and macroscopic flexibility. Its excellent mechanical performance results from a brick-and-mortar like architecture, which combines strong covalent bonding within the single-crystalline nanofibers with an intricate hydrogen bonding network between them. PMID:23468458

  7. Riparian Sediment Delivery Ratio: Stiff Diagrams and Artifical Neural Networks

    EPA Science Inventory

    Various methods are used to estimate sediment transport through riparian buffers and grass jilters with the sediment delivery ratio having been the most widely applied. The U.S. Forest Service developed a sediment delivery ratio using the stiff diagram and a logistic curve to int...

  8. Design optimization of a twist compliant mechanism with nonlinear stiffness

    NASA Astrophysics Data System (ADS)

    Tummala, Y.; Frecker, M. I.; Wissa, A. A.; Hubbard, J. E., Jr.

    2014-10-01

    A contact-aided compliant mechanism called a twist compliant mechanism (TCM) is presented in this paper. This mechanism has nonlinear stiffness when it is twisted in both directions along its axis. The inner core of the mechanism is primarily responsible for its flexibility in one twisting direction. The contact surfaces of the cross-members and compliant sectors are primarily responsible for its high stiffness in the opposite direction. A desired twist angle in a given direction can be achieved by tailoring the stiffness of a TCM. The stiffness of a compliant twist mechanism can be tailored by varying thickness of its cross-members, thickness of the core and thickness of its sectors. A multi-objective optimization problem with three objective functions is proposed in this paper, and used to design an optimal TCM with desired twist angle. The objective functions are to minimize the mass and maximum von-Mises stress observed, while minimizing or maximizing the twist angles under specific loading conditions. The multi-objective optimization problem proposed in this paper is solved for an ornithopter flight research platform as a case study, with the goal of using the TCM to achieve passive twisting of the wing during upstroke, while keeping the wing fully extended and rigid during the downstroke. Prototype TCMs have been fabricated using 3D printing and tested. Testing results are also presented in this paper.

  9. Stiffness of modified Type 1a linear external skeletal fixators.

    PubMed

    Reaugh, H F; Rochat, M C; Bruce, C W; Galloway, D S; Payton, M E

    2007-01-01

    Modifications of a Type 1a external skeletal fixator (ESF) frame were evaluated by alternately placing transfixation pins on opposite sides of the connecting rod (Type 1a-MOD) or by placing additional connecting rods on either of the two inside (Type 1a-INSIDE) or two outside (Type 1a-OUTSIDE) transfixation pins. The objective of this study was to evaluate the stiffness of these modifications in terms of axial compression (AC), cranial-caudal bending (CCB), and medial-lateral bending (MLB). We hypothesized that these designs would allow significant increase in unilateral frame stiffness, over Type 1a, without proportional increase in frame complexity or technical difficulty of application. All of the ESF frames were constructed using large IMEX SKtrade mark clamps, 3.2 mm threaded fixation pins, 9.5 mm carbon fibre connecting rods and Delrin rods as bone models. Nine, eight pin frames of each design were constructed, and subjected to repetitive non-destructive loading forces (AC, CCB, MLB) using a materials testing machine. Frame construct stiffness for each force (AC, CCB, MLB) was derived from load-deformation curve analysis and displayed in N/mm. Data revealed the 1a-MOD and 1a-OUTSIDE constructs had significantly increased stiffness in CCB and AC as compared to the Type 1a constructs while all of the modified constructs were significantly stiffer in MLB than the Type 1a constructs. PMID:18038001

  10. Substrate stiffness affects skeletal myoblast differentiation in vitro

    NASA Astrophysics Data System (ADS)

    Romanazzo, Sara; Forte, Giancarlo; Ebara, Mitsuhiro; Uto, Koichiro; Pagliari, Stefania; Aoyagi, Takao; Traversa, Enrico; Taniguchi, Akiyoshi

    2012-12-01

    To maximize the therapeutic efficacy of cardiac muscle constructs produced by stem cells and tissue engineering protocols, suitable scaffolds should be designed to recapitulate all the characteristics of native muscle and mimic the microenvironment encountered by cells in vivo. Moreover, so not to interfere with cardiac contractility, the scaffold should be deformable enough to withstand muscle contraction. Recently, it was suggested that the mechanical properties of scaffolds can interfere with stem/progenitor cell functions, and thus careful consideration is required when choosing polymers for targeted applications. In this study, cross-linked poly-ɛ-caprolactone membranes having similar chemical composition and controlled stiffness in a supra-physiological range were challenged with two sources of myoblasts to evaluate the suitability of substrates with different stiffness for cell adhesion, proliferation and differentiation. Furthermore, muscle-specific and non-related feeder layers were prepared on stiff surfaces to reveal the contribution of biological and mechanical cues to skeletal muscle progenitor differentiation. We demonstrated that substrate stiffness does affect myogenic differentiation, meaning that softer substrates can promote differentiation and that a muscle-specific feeder layer can improve the degree of maturation in skeletal muscle stem cells.

  11. How crouch gait can dynamically induce stiff-knee gait.

    PubMed

    van der Krogt, Marjolein M; Bregman, Daan J J; Wisse, Martijn; Doorenbosch, Caroline A M; Harlaar, Jaap; Collins, Steven H

    2010-04-01

    Children with cerebral palsy frequently experience foot dragging and tripping during walking due to a lack of adequate knee flexion in swing (stiff-knee gait). Stiff-knee gait is often accompanied by an overly flexed knee during stance (crouch gait). Studies on stiff-knee gait have mostly focused on excessive knee muscle activity during (pre)swing, but the passive dynamics of the limbs may also have an important effect. To examine the effects of a crouched posture on swing knee flexion, we developed a forward-dynamic model of human walking with a passive swing knee, capable of stable cyclic walking for a range of stance knee crouch angles. As crouch angle during stance was increased, the knee naturally flexed much less during swing, resulting in a 'stiff-knee' gait pattern and reduced foot clearance. Reduced swing knee flexion was primarily due to altered gravitational moments around the joints during initial swing. We also considered the effects of increased push-off strength and swing hip flexion torque, which both increased swing knee flexion, but the effect of crouch angle was dominant. These findings demonstrate that decreased knee flexion during swing can occur purely as the dynamical result of crouch, rather than from altered muscle function or pathoneurological control alone.

  12. Variable stiffness and damping suspension system for train

    NASA Astrophysics Data System (ADS)

    Sun, Shuaishuai; Deng, Huaxia; Li, Weihua

    2014-03-01

    As the vibration of high speed train becomes fierce when the train runs at high speed, it is crucial to develop a novel suspension system to negotiate train's vibration. This paper presents a novel suspension based on Magnetorheological fluid (MRF) damper and MRF based smart air spring. The MRF damper is used to generate variable damping while the smart air spring is used to generate field-dependent stiffness. In this paper, the two kind smart devices, MRF dampers and smart air spring, are developed firstly. Then the dynamic performances of these two devices are tested by MTS. Based on the testing results, the two devices are equipped to a high speed train which is built in ADAMS. The skyhook control algorithm is employed to control the novel suspension. In order to compare the vibration suppression capability of the novel suspension with other kind suspensions, three other different suspension systems are also considered and simulated in this paper. The other three kind suspensions are variable damping with fixed stiffness suspension, variable stiffness with fixed damping suspension and passive suspension. The simulation results indicate that the variable damping and stiffness suspension suppresses the vibration of high speed train better than the other three suspension systems.

  13. INTERIOR VIEW WITH STIFF LEG LADLE CRANE OPERATOR, LUKE WALKER, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW WITH STIFF LEG LADLE CRANE OPERATOR, LUKE WALKER, POURING OFF SLAG FROM LADLE AS SKIMMER, BRUCE ELLIOTT, RAKES THE SLAG FROM THE MOLTEN METAL. - American Cast Iron Pipe Company, Mixer Building, 1501 Thirty-first Avenue North, Birmingham, Jefferson County, AL

  14. Arterial stiffness of lifelong Japanese female pearl divers.

    PubMed

    Tanaka, Hirofumi; Tomoto, Tsubasa; Kosaki, Keisei; Sugawara, Jun

    2016-05-15

    Japanese female pearl divers called Ama specialize in free diving in the cold sea for collecting foods and pearls in oysters. Exercising in the water combined with marked bradycardia and pressor responses provides a circulatory challenge to properly buffer or cushion elevated cardiac pulsations. Because Ama perform repeated free dives throughout their lives, it is possible that they may have adapted similar arterial structure and function to those seen in diving mammals. We compared arterial stiffness of lifelong Japanese pearl divers with age-matched physically inactive adults living in the same fishing villages. A total of 115 Japanese female pearl divers were studied. Additionally, 50 physically inactive adults as well as 33 physically active adults (participating in community fitness programs) living in the same coastal villages were also studied. There were no differences in age (∼65 yr), body mass index, and brachial blood pressure between the groups. Measures of arterial stiffness, cardio-ankle vascular index and β-stiffness index were lower (P < 0.05) in pearl divers and physically active adults than in their physically inactive peers. Augmentation pressure and augmentation index adjusted for the heart rate of 75 beats/min were lower (P < 0.05) in pearl divers than in other groups. These results indicate that lifelong Japanese pearl divers demonstrate reduced arterial stiffness and arterial wave reflection compared with age-matched physically inactive peers living in the same fishing villages. PMID:26984889

  15. Variable Stiffness Spar Wind-Tunnel Model Development and Testing

    NASA Technical Reports Server (NTRS)

    Florance, James R.; Heeg, Jennifer; Spain, Charles V.; Ivanco, Thomas G.; Wieseman, Carol D.; Lively, Peter S.

    2004-01-01

    The concept of exploiting wing flexibility to improve aerodynamic performance was investigated in the wind tunnel by employing multiple control surfaces and by varying wing structural stiffness via a Variable Stiffness Spar (VSS) mechanism. High design loads compromised the VSS effectiveness because the aerodynamic wind-tunnel model was much stiffer than desired in order to meet the strength requirements. Results from tests of the model include stiffness and modal data, model deformation data, aerodynamic loads, static control surface derivatives, and fuselage standoff pressure data. Effects of the VSS on the stiffness and modal characteristics, lift curve slope, and control surface effectiveness are discussed. The VSS had the most effect on the rolling moment generated by the leading-edge outboard flap at subsonic speeds. The effects of the VSS for the other control surfaces and speed regimes were less. The difficulties encountered and the ability of the VSS to alter the aeroelastic characteristics of the wing emphasize the need for the development of improved design and construction methods for static aeroelastic models. The data collected and presented is valuable in terms of understanding static aeroelastic wind-tunnel model development.

  16. Nanostructured conducting polymers for stiffness controlled cell adhesion

    NASA Astrophysics Data System (ADS)

    Moyen, Eric; Hama, Adel; Ismailova, Esma; Assaud, Loic; Malliaras, George; Hanbücken, Margrit; Owens, Roisin M.

    2016-02-01

    We propose a facile and reproducible method, based on ultra thin porous alumina membranes, to produce cm2 ordered arrays of nano-pores and nano-pillars on any kind of substrates. In particular our method enables the fabrication of conducting polymers nano-structures, such as poly[3,4-ethylenedioxythiophene]:poly[styrene sulfonate] (PEDOT:PSS). Here, we demonstrate the potential interest of those templates with controlled cell adhesion studies. The triggering of the eventual fate of the cell (proliferation, death, differentiation or migration) is mediated through chemical cues from the adsorbed proteins and physical cues such as surface energy, stiffness and topography. Interestingly, as well as through material properties, stiffness modifications can be induced by nano-topography, the ability of nano-pillars to bend defining an effective stiffness. By controlling the diameter, length, depth and material of the nano-structures, one can possibly tune the effective stiffness of a (nano) structured substrate. First results indicate a possible change in the fate of living cells on such nano-patterned devices, whether they are made of conducting polymer (soft material) or silicon (hard material).

  17. [Progress on cervical muscle strength and soft tissue stiffness testing].

    PubMed

    Ma, Ming; Zhang, Shi-min

    2015-08-01

    Biomechanical evaluation of neck muscles has important significance in the diagnosis and treatment for cervical spondylosis, the neck muscle strength and soft tissue stiffness test is two aspects of biomechanical testing. Isometric muscle testing operation is relatively simple, the cost is lower, which can evaluate the muscle force below grade 3. However, isokinetic muscle strength testing can assess the muscle strength of joint motion in any position. It is hard to distinguish stiffness difference in different soft tissues when the load-displacement curve is used to evaluate the local soft tissue stiffness. Elasticity imaging technique can not only show the elastic differences of different tissues by images, but also quantify the elastic modulus of subcutaneous tissues and muscles respectively. Nevertheless, it is difficult to observe the flexibility of the cervical spine by means of the analysis of the whole neck stiffness. In a word, a variety of test method will conduce not only the biomechanical evaluation of neck muscles, but also making an effective biomechanics mathematical model of neck muscles. Besides, isokinetic muscle testing and the elasticity imaging technology still need further validation and optimization before they are better applied to neck muscles biomechanical testing.

  18. Initial post-buckling of variable-stiffness curved panels

    NASA Astrophysics Data System (ADS)

    White, S. C.; Raju, G.; Weaver, P. M.

    2014-11-01

    Variable-stiffness shells are curved composite structures in which the fibre-reinforcement follow curvilinear paths in space. Having a wider design space than traditional composite shells, they have the potential to improve a wide variety of weight-critical structures. In this paper, a new method for computing the initial post-buckling response of variable-stiffness cylindrical panels is presented, based on the differential quadrature method. Integro-differential governing and boundary equations governing the problem, derived with Koiter's theory (Koiter, 1945), are solved using a mixed generalised differential quadrature (GDQ) and integral quadrature (GIQ) approach. The post-buckling behaviour is determined on the basis of a quadratic expansion of the displacement fields. Orthogonality of the mode-shapes in the expansion series is ensured by a novel use of the Moore-Penrose generalised matrix inverse for solving the GDQ-GIQ equations. The new formulation is validated against benchmark analytical post-buckling results for constant stiffness plates and shells, and compared with non-linear finite-element (FE) analysis for variable-stiffness shells. Stability estimates are found to be in good agreement with incremental FE results in the vicinity of the buckling load, requiring only a fraction of the number of variables used by the current method.

  19. On the development of planar actuators for variable stiffness devices

    NASA Astrophysics Data System (ADS)

    Henke, Markus; Gerlach, Gerald

    2013-04-01

    This contribution describes the development, the potential and the limitations of planar actuators for controlling bending devices with variable stiffness. Such structures are supposed to be components of new smart, self-sensing and -controlling composite materials for lightweight constructions. To realize a proper stiffness control, it is necessary to develop reliable actuators with high actuation capabilities based on smart materials. Several actuator designs driven by electroactive polymers (EAPs) are presented and discussed regarding to their applicability in such structures. To investigate the actuators, variable-flexural stiffness devices based on the control of its area moment of inertia were developed. The devices consist of a multi-layer stack of thin, individual plates. Stiffness variation is caused by planar actuators which control the sliding behavior between the layers by form closure structures. Previous investigations have shown that actuators with high actuation potential are needed to ensure reliable connections between the layers. For that reason, two kinds of EAPs Danfoss PolyPower and VHB 4905 by 3M, have been studied as driving unit. These EAP-driven actuators will be compared based on experimental measurements and finite element analyses.

  20. Torsion stiffness of a protein pair determined by magnetic particles.

    PubMed

    Janssen, X J A; van Noorloos, J M; Jacob, A; van Ijzendoorn, L J; de Jong, A M; Prins, M W J

    2011-05-01

    We demonstrate the ability to measure torsion stiffness of a protein complex by applying a controlled torque on a magnetic particle. As a model system we use protein G bound to an IgG antibody. The protein pair is held between a magnetic particle and a polystyrene substrate. The angular orientation of the magnetic particle shows an oscillating behavior upon application of a rotating magnetic field. The amplitude of the oscillation increases with a decreasing surface coverage of antibodies on the substrate and with an increasing magnitude of the applied field. For decreasing antibody coverage, the torsion spring constant converges to a minimum value of 1.5 × 10(3) pN·nm/rad that corresponds to a torsion modulus of 4.5 × 10(4) pN·nm(2). This torsion stiffness is an upper limit for the molecular bond between the particle and the surface that is tentatively assigned to a single protein G-IgG protein pair. This assignment is supported by interpreting the measured stiffness with a simple mechanical model that predicts a two orders of magnitude larger stiffness for the protein G-IgG complex than values found for micrometer length dsDNA. This we understand from the structural properties of the molecules, i.e., DNA is a long and flexible chain-like molecule, whereas the antibody-antigen couple is orders of magnitude smaller and more globular in shape due to the folding of the molecules.

  1. Rotordynamic coefficients and leakage flow of parallel grooved seals and smooth seals

    NASA Technical Reports Server (NTRS)

    Nordmann, R.; Dietzen, F. J.; Janson, W.; Frei, A.; Florjancic, S.

    1987-01-01

    Based on Childs finite length solution for annular plain seals an extension of the bulk flow theory is derived to calculate the rotordynamic coefficients and the leakage flow of seals with parallel grooves in the stator. Hirs turbulent lubricant equations are modified to account for the different friction factors in circumferential and axial direction. Furthermore an average groove depth is introduced to consider the additional circumferential flow in the grooves. Theoretical and experimental results are compared for the smooth constant clearance seal and the corresponding seal with parallel grooves. Compared to the smooth seal the direct and cross-coupled stiffness coefficients as well as the direct damping coefficients are lower in the grooved seal configuration. Leakage is reduced by the grooving pattern.

  2. Theory and measurements of labyrinth seal coefficients for rotor stability of turbocompressors

    NASA Technical Reports Server (NTRS)

    Syssmann, H. R.

    1987-01-01

    The prediction of rotordynamic coefficients for gas seals is achieved with the aid of a two-volume bulk flow model based on turbulent rotationally symmetric 3D flow calculations including swirl flow. Comparison of cross-coupling and damping coefficients with measurements confirm this approach. In particular the theoretically predicted phenomenon that labyrinth damping is retained without inlet swirl is confirmed. This is important for the design of high pressure compressors, where labyrinth damping is a major contribution improving rotor stability. Discrepancies are found when comparing theory with measured direct stiffness and the cross-coupling damping coefficients. First measurements of labyrinth seals on a recently installed test rig operated with water are presented. Since forces are larger than on test stands operated with air and since individual chamber forces are obtained phenomena like inlet effects may be studied.

  3. Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study

    PubMed Central

    Caviezel, Seraina; Schaffner, Emmanuel; Dratva, Julia; Schindler, Christian; Künzli, Nino; Bachler, Martin; Wassertheurer, Siegfried; Probst-Hensch, Nicole; Schmidt-Trucksäss, Arno

    2016-01-01

    Background and Objectives There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional vascular biomarkers in a population-based Caucasian cohort. We examined these associations in the second follow-up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA 3). Methods Arterial stiffness was measured oscillometrically by pulse wave analysis to derive the cardio-ankle vascular index (CAVI), brachial-ankle (baPWV) and aortic pulse wave velocity (aPWV), and amplitude of the forward and backward wave. Carotid ultrasonography was used to measure carotid intima-media thickness (cIMT) and carotid lumen diameter (LD), and to derive a distensibility coefficient (DC). We used multivariable linear regression models adjusted for several potential confounders for 2,733 people aged 50–81 years. Results CAVI, aPWV and the amplitude of the forward and backward wave were significant predictors of cIMT (p < 0.001). All parameters were significantly associated with LD (p < 0.001), with aPWV and the amplitude of the forward wave explaining the highest proportion of variance (2%). Only CAVI and baPWV were significant predictors of DC (p < 0.001), explaining more than 0.3% of the DC variance. Conclusion We demonstrated that novel non-invasive oscillometric arterial stiffness parameters are differentially associated with specific established structural and functional local stiffness parameters. Longitudinal studies are needed to follow-up on these cross-sectional findings and to evaluate their relevance for clinical phenotypes. PMID:27685325

  4. Effect of Nanoconfinement on the Glass Transition Temperature and Small Molecule Diffusion in Polymers of Varying Backbone Stiffness

    NASA Astrophysics Data System (ADS)

    Deng, Hui; Mundra, Manish; Torkelson, John

    2010-03-01

    Fluorescence spectroscopy was used to determine the glass transition temperature in ultrathin supported bisphenol-A polysulfone (BPAPS) and bisphenol-A polycarbonate (BPAPC) films and compared to previous results for ultrathin supported polystyrene (PS) films. BPAPC and BPAPS are more rigid than PS due to the presence of aromatic rings in their polymer backbones. A dramatic increase in Tg-reduction upon confinement was seen for polymers with increased backbone stiffness. A fluorescence-multilayer film technique was then used to determine the diffusion coefficient of a small molecule probe in ultrathin supported PS films. A decrease in the diffusion coefficient of the probe was observed upon confinement of the PS films. This procedure is also being applied to ultrathin supported BPAPC and BPAPS films to explore the impact of polymer backbone rigidity on small molecule diffusion in nanoconfined polymers.

  5. The conundrum of arterial stiffness, elevated blood pressure, and aging.

    PubMed

    AlGhatrif, Majd; Lakatta, Edward G

    2015-02-01

    Isolated systolic hypertension is a major health burden that is expanding with the aging of our population. There is evidence that central arterial stiffness contributes to the rise in systolic blood pressure (SBP); at the same time, central arterial stiffening is accelerated in patients with increased SBP. This bidirectional relationship created a controversy in the field on whether arterial stiffness leads to hypertension or vice versa. Given the profound interdependency of arterial stiffness and blood pressure, this question seems intrinsically challenging, or probably naïve. The aorta's function of dampening the pulsatile flow generated by the left ventricle is optimal within a physiological range of distending pressure that secures the required distal flow, keeps the aorta in an optimal mechanical conformation, and minimizes cardiac work. This homeostasis is disturbed by age-associated, minute alterations in aortic hemodynamic and mechanical properties that induce short- and long-term alterations in each other. Hence, it is impossible to detect an "initial insult" at an epidemiological level. Earlier manifestations of these alterations are observed in young adulthood with a sharp decline in aortic strain and distensibility accompanied by an increase in diastolic blood pressure. Subsequently, aortic mechanical reserve is exhausted, and aortic remodeling with wall stiffening and dilatation ensue. These two phenomena affect pulse pressure in opposite directions and different magnitudes. With early remodeling, there is an increase in pulse pressure, due to the dominance of arterial wall stiffness, which in turn accelerates aortic wall stiffness and dilation. With advanced remodeling, which appears to be greater in men, the effect of diameter becomes more pronounced and partially offsets the effect of wall stiffness leading to plateauing in pulse pressure in men and slower increase in pulse pressure (PP) than that of wall stiffness in women. The complex nature of

  6. Reliability Generalization: "Lapsus Linguae"

    ERIC Educational Resources Information Center

    Smith, Julie M.

    2011-01-01

    This study examines the proposed Reliability Generalization (RG) method for studying reliability. RG employs the application of meta-analytic techniques similar to those used in validity generalization studies to examine reliability coefficients. This study explains why RG does not provide a proper research method for the study of reliability,…

  7. Impact testing of the residual limb: System response to changes in prosthetic stiffness.

    PubMed

    Boutwell, Erin; Stine, Rebecca; Gard, Steven

    2016-01-01

    Currently, it is unknown whether changing prosthetic limb stiffness affects the total limb stiffness and influences the shock absorption of an individual with transtibial amputation. The hypotheses tested within this study are that a decrease in longitudinal prosthetic stiffness will produce (1) a reduced total limb stiffness, and (2) reduced magnitude of peak impact forces and increased time delay to peak force. Fourteen subjects with a transtibial amputation participated in this study. Prosthetic stiffness was modified by means of a shock-absorbing pylon that provides reduced longitudinal stiffness through compression of a helical spring within the pylon. A sudden loading evaluation device was built to examine changes in limb loading mechanics during a sudden impact event. No significant change was found in the peak force magnitude or timing of the peak force between prosthetic limb stiffness conditions. Total limb stiffness estimates ranged from 14.9 to 17.9 kN/m but were not significantly different between conditions. Thus, the prosthetic-side total limb stiffness was unaffected by changes in prosthetic limb stiffness. The insensitivity of the total limb stiffness to prosthetic stiffness may be explained by the mechanical characteristics (i.e., stiffness and damping) of the anatomical tissue within the residual limb. PMID:27272982

  8. Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness

    PubMed Central

    Müller, Anna E.; Kreiner, Matthias; Kötter, Sebastian; Lassak, Philipp; Bloch, Wilhelm; Suhr, Frank; Krüger, Martina

    2014-01-01

    Titin-based myofilament stiffness is largely modulated by phosphorylation of its elastic I-band regions N2-Bus (decreases passive stiffness, PT) and PEVK (increases PT). Here, we tested the hypothesis that acute exercise changes titin phosphorylation and modifies myofilament stiffness. Adult rats were exercised on a treadmill for 15 min, untrained animals served as controls. Titin phosphorylation was determined by Western blot analysis using phosphospecific antibodies to Ser4099 and Ser4010 in the N2-Bus region (PKG and PKA-dependent. respectively), and to Ser11878 and Ser 12022 in the PEVK region (PKCα and CaMKIIδ-dependent, respectively). Passive tension was determined by step-wise stretching of isolated skinned cardiomyocytes to sarcomere length (SL) ranging from 1.9 to 2.4 μm and showed a significantly increased PT from exercised samples, compared to controls. In cardiac samples titin N2-Bus phosphorylation was significantly decreased by 40% at Ser4099, however, no significant changes were observed at Ser4010. PEVK phosphorylation at Ser11878 was significantly increased, which is probably mediated by the observed exercise-induced increase in PKCα activity. Interestingly, relative phosphorylation of Ser12022 was substantially decreased in the exercised samples. Surprisingly, in skeletal samples from acutely exercised animals we detected a significant decrease in PEVK phosphorylation at Ser11878 and an increase in Ser12022 phosphorylation; however, PKCα activity remained unchanged. In summary, our data show that a single exercise bout of 15 min affects titin domain phosphorylation and titin-based myocyte stiffness with obviously divergent effects in cardiac and skeletal muscle tissues. The observed changes in titin stiffness could play an important role in adapting the passive and active properties of the myocardium and the skeletal muscle to increased physical activity. PMID:25477822

  9. On the role of CFRP reinforcement for wood beams stiffness

    NASA Astrophysics Data System (ADS)

    Ianasi, A. C.

    2015-11-01

    In recent years, carbon fiber composites have been increasingly used in different ways in reinforcing structural elements. Specifically, the use of composite materials as a reinforcement for wood beams under bending loads requires paying attention to several aspects of the problem such as the number of the composite layers applied on the wood beams. Study consolidation of composites revealed that they are made by bonding fibrous material impregnated with resin on the surface of various elements, to restore or increase the load carrying capacity (bending, cutting, compression or torque) without significant damage of their rigidity. Fibers used in building applications can be fiberglass, aramid or carbon. Items that can be strengthened are concrete, brick, wood, steel and stone, and in terms of structural beams, walls, columns and floors. This paper describes an experimental study which was designed to evaluate the effect of composite material on the stiffness of the wood beams. It proposes a summary of the fundamental principles of analysis of composite materials and the design and use. The type of reinforcement used on the beams is the carbon fiber reinforced polymer (CFRP) sheet and plates and also an epoxy resin for bonding all the elements. Structural epoxy resins remain the primary choice of adhesive to form the bond to fiber-reinforced plastics and are the generally accepted adhesives in bonded CFRP-wood connections. The advantages of using epoxy resin in comparison to common wood-laminating adhesives are their gap-filling qualities and the low clamping pressures that are required to form the bond between carbon fiber plates or sheets and the wood beams. Mechanical tests performed on the reinforced wood beams showed that CFRP materials may produce flexural displacement and lifting increases of the beams. Observations of the experimental load-displacement relationships showed that bending strength increased for wood beams reinforced with CFRP composite plates

  10. Using two coefficients modeling of nonsubsampled Shearlet transform for despeckling

    NASA Astrophysics Data System (ADS)

    Jafari, Saeed; Ghofrani, Sedigheh

    2016-01-01

    Synthetic aperture radar (SAR) images are inherently affected by multiplicative speckle noise. Two approaches based on modeling the nonsubsampled Shearlet transform (NSST) coefficients are presented. Two-sided generalized Gamma distribution and normal inverse Gaussian probability density function have been used to model the statistics of NSST coefficients. Bayesian maximum a posteriori estimator is applied to the corrupted NSST coefficients in order to estimate the noise-free NSST coefficients. Finally, experimental results, according to objective and subjective criteria, carried out on both artificially speckled images and the true SAR images, demonstrate that the proposed methods outperform other state of art references via two points of view, speckle noise reduction and image quality preservation.

  11. An instrumental variable random-coefficients model for binary outcomes

    PubMed Central

    Chesher, Andrew; Rosen, Adam M

    2014-01-01

    In this paper, we study a random-coefficients model for a binary outcome. We allow for the possibility that some or even all of the explanatory variables are arbitrarily correlated with the random coefficients, thus permitting endogeneity. We assume the existence of observed instrumental variables Z that are jointly independent with the random coefficients, although we place no structure on the joint determination of the endogenous variable X and instruments Z, as would be required for a control function approach. The model fits within the spectrum of generalized instrumental variable models, and we thus apply identification results from our previous studies of such models to the present context, demonstrating their use. Specifically, we characterize the identified set for the distribution of random coefficients in the binary response model with endogeneity via a collection of conditional moment inequalities, and we investigate the structure of these sets by way of numerical illustration. PMID:25798048

  12. Correlation equation for the marine drag coefficient and wave steepness

    NASA Astrophysics Data System (ADS)

    Foreman, Richard J.; Emeis, Stefan

    2012-09-01

    This work questions, starting from dimensional considerations, the generality of the belief that the marine drag coefficient levels off with increasing wind speed. Dimensional analysis shows that the drag coefficient scales with the wave steepness as opposed to a wave-age scaling. A correlation equation is employed here that uses wave steepness scaling at low aspect ratios (inverse wave steepnesses) and a constant drag coefficient at high aspect ratios. Invoked in support of the correlation are measurements sourced from the literature and at the FINO1 platform in the North Sea. The correlation equation is then applied to measurements recorded from buoys during the passage of hurricanes Rita, Katrina (2005) and Ike (2008). Results show that the correlation equation anticipates the expected levelling off in deeper water, but a drag coefficient more consistent with a Charnock type relation is also possible in more shallower water. Some suggestions are made for proceeding with a higher-order analysis than that conducted here.

  13. Rotordynamic coefficients for stepped labyrinth gas seals

    NASA Technical Reports Server (NTRS)

    Scharrer, Joseph K.

    1989-01-01

    The basic equations are derived for compressible flow in a stepped labyrinth gas seal. The flow is assumed to be completely turbulent in the circumferential direction where the friction factor is determined by the Blasius relation. Linearized zeroth and first-order perturbation equations are developed for small motion about a centered position by an expansion in the eccentricity ratio. The zeroth-order pressure distribution is found by satisfying the leakage equation while the circumferential velocity distribution is determined by satisfying the momentum equations. The first order equations are solved by a separation of variables solution. Integration of the resultant pressure distribution along and around the seal defines the reaction force developed by the seal and the corresponding dynamic coefficients. The results of this analysis are presented in the form of a parametric study, since there are no known experimental data for the rotordynamic coefficients of stepped labyrinth gas seals. The parametric study investigates the relative rotordynamic stability of convergent, straight and divergent stepped labyrinth gas seals. The results show that, generally, the divergent seal is more stable, rotordynamically, than the straight or convergent seals. The results also show that the teeth-on-stator seals are not always more stable, rotordynamically, then the teeth-on-rotor seals as was shown by experiment by Childs and Scharrer (1986b) for a 15 tooth seal.

  14. Coefficient adaptive triangulation for strongly anisotropic problems

    SciTech Connect

    D`Azevedo, E.F.; Romine, C.H.; Donato, J.M.

    1996-01-01

    Second order elliptic partial differential equations arise in many important applications, including flow through porous media, heat conduction, the distribution of electrical or magnetic potential. The prototype is the Laplace problem, which in discrete form produces a coefficient matrix that is relatively easy to solve in a regular domain. However, the presence of anisotropy produces a matrix whose condition number is increased, making the resulting linear system more difficult to solve. In this work, we take the anisotropy into account in the discretization by mapping each anisotropic region into a ``stretched`` coordinate space in which the anisotropy is removed. The region is then uniformly triangulated, and the resulting triangulation mapped back to the original space. The effect is to generate long slender triangles that are oriented in the direction of ``preferred flow.`` Slender triangles are generally regarded as numerically undesirable since they tend to cause poor conditioning; however, our triangulation has the effect of producing effective isotropy, thus improving the condition number of the resulting coefficient matrix.

  15. Measurements of thermal accommodation coefficients.

    SciTech Connect

    Rader, Daniel John; Castaneda, Jaime N.; Torczynski, John Robert; Grasser, Thomas W.; Trott, Wayne Merle

    2005-10-01

    A previously-developed experimental facility has been used to determine gas-surface thermal accommodation coefficients from the pressure dependence of the heat flux between parallel plates of similar material but different surface finish. Heat flux between the plates is inferred from measurements of temperature drop between the plate surface and an adjacent temperature-controlled water bath. Thermal accommodation measurements were determined from the pressure dependence of the heat flux for a fixed plate separation. Measurements of argon and nitrogen in contact with standard machined (lathed) or polished 304 stainless steel plates are indistinguishable within experimental uncertainty. Thus, the accommodation coefficient of 304 stainless steel with nitrogen and argon is estimated to be 0.80 {+-} 0.02 and 0.87 {+-} 0.02, respectively, independent of the surface roughness within the range likely to be encountered in engineering practice. Measurements of the accommodation of helium showed a slight variation with 304 stainless steel surface roughness: 0.36 {+-} 0.02 for a standard machine finish and 0.40 {+-} 0.02 for a polished finish. Planned tests with carbon-nanotube-coated plates will be performed when 304 stainless-steel blanks have been successfully coated.

  16. Zero finite-temperature charge stiffness within the half-filled 1D Hubbard model

    SciTech Connect

    Carmelo, J.M.P.; Gu, Shi-Jian; Sacramento, P.D.

    2013-12-15

    Even though the one-dimensional (1D) Hubbard model is solvable by the Bethe ansatz, at half-filling its finite-temperature T>0 transport properties remain poorly understood. In this paper we combine that solution with symmetry to show that within that prominent T=0 1D insulator the charge stiffness D(T) vanishes for T>0 and finite values of the on-site repulsion U in the thermodynamic limit. This result is exact and clarifies a long-standing open problem. It rules out that at half-filling the model is an ideal conductor in the thermodynamic limit. Whether at finite T and U>0 it is an ideal insulator or a normal resistor remains an open question. That at half-filling the charge stiffness is finite at U=0 and vanishes for U>0 is found to result from a general transition from a conductor to an insulator or resistor occurring at U=U{sub c}=0 for all finite temperatures T>0. (At T=0 such a transition is the quantum metal to Mott–Hubbard-insulator transition.) The interplay of the η-spin SU(2) symmetry with the hidden U(1) symmetry beyond SO(4) is found to play a central role in the unusual finite-temperature charge transport properties of the 1D half-filled Hubbard model. -- Highlights: •The charge stiffness of the half-filled 1D Hubbard model is evaluated. •Its value is controlled by the model symmetry operator algebras. •We find that there is no charge ballistic transport at finite temperatures T>0. •The hidden U(1) symmetry controls the U=0 phase transition for T>0.

  17. Clustering stocks using partial correlation coefficients

    NASA Astrophysics Data System (ADS)

    Jung, Sean S.; Chang, Woojin

    2016-11-01

    A partial correlation analysis is performed on the Korean stock market (KOSPI). The difference between Pearson correlation and the partial correlation is analyzed and it is found that when conditioned on the market return, Pearson correlation coefficients are generally greater than those of the partial correlation, which implies that the market return tends to drive up the correlation between stock returns. A clustering analysis is then performed to study the market structure given by the partial correlation analysis and the members of the clusters are compared with the Global Industry Classification Standard (GICS). The initial hypothesis is that the firms in the same GICS sector are clustered together since they are in a similar business and environment. However, the result is inconsistent with the hypothesis and most clusters are a mix of multiple sectors suggesting that the traditional approach of using sectors to determine the proximity between stocks may not be sufficient enough to diversify a portfolio.

  18. Transparent composite model for DCT coefficients: design and analysis.

    PubMed

    Yang, En-Hui; Yu, Xiang; Meng, Jin; Sun, Chang

    2014-03-01

    The distributions of discrete cosine transform (DCT) coefficients of images are revisited on a per image base. To better handle, the heavy tail phenomenon commonly seen in the DCT coefficients, a new model dubbed a transparent composite model (TCM) is proposed and justified for both modeling accuracy and an additional data reduction capability. Given a sequence of the DCT coefficients, a TCM first separates the tail from the main body of the sequence. Then, a uniform distribution is used to model the DCT coefficients in the heavy tail, whereas a different parametric distribution is used to model data in the main body. The separate boundary and other parameters of the TCM can be estimated via maximum likelihood estimation. Efficient online algorithms are proposed for parameter estimation and their convergence is also proved. Experimental results based on Kullback-Leibler divergence and χ(2) test show that for real-valued continuous ac coefficients, the TCM based on truncated Laplacian offers the best tradeoff between modeling accuracy and complexity. For discrete or integer DCT coefficients, the discrete TCM based on truncated geometric distributions (GMTCM) models the ac coefficients more accurately than pure Laplacian models and generalized Gaussian models in majority cases while having simplicity and practicality similar to those of pure Laplacian models. In addition, it is demonstrated that the GMTCM also exhibits a good capability of data reduction or feature extraction-the DCT coefficients in the heavy tail identified by the GMTCM are truly outliers, and these outliers represent an outlier image revealing some unique global features of the image. Overall, the modeling performance and the data reduction feature of the GMTCM make it a desirable choice for modeling discrete or integer DCT coefficients in the real-world image or video applications, as summarized in a few of our further studies on quantization design, entropy coding design, and image understanding

  19. Turbulent MHD transport coefficients - An attempt at self-consistency

    NASA Technical Reports Server (NTRS)

    Chen, H.; Montgomery, D.

    1987-01-01

    In this paper, some multiple scale perturbation calculations of turbulent MHD transport coefficients begun in earlier papers are first completed. These generalize 'alpha effect' calculations by treating the velocity field and magnetic field on the same footing. Then the problem of rendering such calculations self-consistent is addressed, generalizing an eddy-viscosity hypothesis similar to that of Heisenberg for the Navier-Stokes case. The method also borrows from Kraichnan's direct interaction approximation. The output is a set of integral equations relating the spectra and the turbulent transport coefficients. Previous 'alpha effect' and 'beta effect' coefficients emerge as limiting cases. A treatment of the inertial range can also be given, consistent with a -5/3 energy spectrum power law. In the Navier-Stokes limit, a value of 1.72 is extracted for the Kolmogorov constant. Further applications to MHD are possible.

  20. Role of Mineralocorticoid Receptors in Arterial Stiffness in Human Aging

    PubMed Central

    Hwang, Moon-Hyon; Yoo, Jeung-Ki; Luttrell, Meredith; Kim, Han-Kyul; Meade, Thomas H.; English, Mark; Nichols, Wilmer W.; Christou, Demetra D.

    2013-01-01

    Arterial stiffness, an independent predictor of cardiovascular disease, is increased in aging, but the underlying mechanisms are not completely understood. Mineralocorticoid receptors (MR) may contribute to oxidative stress and arterial stiffness in healthy older adults. To test the hypothesis that short-term MR blockade may reduce oxidative stress and improve arterial stiffness, we conducted a randomized, double blind, crossover study using the selective MR blocker Eplerenone or placebo in 23 older adults (age, 64±1 years; mean±SE) free from overt cardiovascular and other clinical disease (e.g, diabetes, renal and liver disease). In response to MR blockade, brachial and carotid blood pressure decreased (P≤0.01). However, MR blockade had no effect on oxidative stress (oxidized LDL, 61.2±6.8 vs. 62.4±7.4 U/L, P=0.9; placebo vs. Eplerenone) and arterial stiffness (aortic pulse wave velocity (PWV), 9.17±1.19 vs. 8.92±1.19 m/sec, P=0.5; leg PWV, 13.45±0.45 vs. 12.81±0.47 m/sec, P=0.3; arm PWV, 11.43±0.62 vs. 11.73±0.68 m/sec, P=0.7; carotid artery compliance, 0.150±0.013 vs. 0.149±0.014 mm2/mmHg, P=0.8; distensibility, 23.1±1.8 vs. 23.3±1.7 10−3/kPa, P=0.8; β stiffness index, 3.5±0.3 vs. 3.6±0.3, P=0.6; and augmentation index, 16.0±2.2 vs. 15.6±2.8 %, P=0.8). These results provide the first evidence that MR do not appear to contribute to oxidative stress in human aging and that short-term MR blockade does not result in reduced oxidative stress and improved arterial stiffness. PMID:23707930