Science.gov

Sample records for generals carl von

  1. [Hermann von Helmholtz and Carl Stumpf on consonance and dissonance].

    PubMed

    Kursell, Julia

    2008-06-01

    The article juxtaposes Hermann von Helmholtz's work in the experimental physiology of hearing and Carl Stumpf's tone psychology, focusing on the problem of consonance and dissonance in music. It argues that the experimental set-up plays a major role in the approaches to hearing of both Helmholtz and Stumpf, shaping their redefinition of the musical concepts of consonance and dissonance. Helmholtz, however, explains dissonance as resulting from the beats that are heard when sound waves interfere, while Stumpf explains consonance from the fusion (Verschmelzung) of sounds, noting that two tones, depending on their distance cannot always be recognized as two but are heard as one single tone. Helmholtz's definition of dissonance eventually threatens his own theory of hearing, which is based on the mechanical principle of resonance and considers sound to be composed of sinusoidal waves. Both the physical and the mathematical tools he uses cannot easily be brought into accordance with his experimental findings on beats, which ask for a discrimination of fast changes in intensity. Dissonance thus becomes "unrecomendable" for Helmholtz, because it overstrains the ear. Stumpf's research, in contrast, has its point of departure in the historically given set of intervals and tries to find a principle that would explain this choice. His tests with experimental subjects who have no conscious knowledge of musical harmony and prove incapable to follow or reproduce music reveals to him a difference between the unity and multiplicity of tones.

  2. [Carl Friedrich von Weizsäcker - physicist and philosopher].

    PubMed

    Drieschner, Michael

    2014-01-01

    The subject of this paper is the philosopher Carl Friedrich von weizsäcker, especially under the aspect of the relation between physics and philosophy in his works. The decisive role of time in physics as well as in philosophy is described, and thereof is derived the comprehension of probability as a predicted relative frequency. Consequently quantum mechanics is interpreted as a theory of probability that uses "quantum logic" instead of classical propositional logic that is used in "normal" probability. The philosophical fruit of that is the interpretation of potentiality as the modality of the future. Weizsäcker's proposals for a justification of physics a priori are dealt with as well as his approach to a theory of "ur-objects", which are atoms in the strictest sense: q-bits.--Questions of Weizsäcker's personality are addressed: His role in the development of the nuclear reactor and atomic bomb in Nazi time, his enthusiasm and his religiousness as well as his efforts towards world peace.

  3. [Carl Friedrich von Weizsäcker's philosophy of the mind].

    PubMed

    Lyre, Holger

    2014-01-01

    The paper deals with Carl Friedrich von Weizsäcker's position within the philosophy of mind. It turns out that Weizsäcker's ontology is based on an unorthodox conception both in the philosophy of physics and in the philosophy of mind. His quantum information theoretic reductionism is based on a subtle combination of atomism and holism, his philosophy of mind connected to this is a neutral monism, which proposes a bold intertwining of mind, matter, and space.

  4. [Carl Friedrich von Weizsäcker's philosophy of the mind].

    PubMed

    Lyre, Holger

    2014-01-01

    The paper deals with Carl Friedrich von Weizsäcker's position within the philosophy of mind. It turns out that Weizsäcker's ontology is based on an unorthodox conception both in the philosophy of physics and in the philosophy of mind. His quantum information theoretic reductionism is based on a subtle combination of atomism and holism, his philosophy of mind connected to this is a neutral monism, which proposes a bold intertwining of mind, matter, and space. PMID:24974603

  5. Werner Heisenberg and Carl Friedrich Freiherr von Weizsäcker: A Fifty-Year Friendship*

    NASA Astrophysics Data System (ADS)

    Cassidy, David C.

    2015-03-01

    This paper follows Werner Heisenberg and Carl Friedrich von Weizsäcker during their fifty-year friendship from 1926, when they first met in Copenhagen, to Heisenberg's death in Munich in 1976. The relationship underwent profound changes during that period, as did physics, philosophy, and German society and politics, all of which exerted important influences on their lives, work, and interactions with each other. The nature of these developments and their impact are explored in this paper.

  6. ["Living with the bomb" - Carl Friedrich von Weizsäcker's path from physics to politics].

    PubMed

    Walker, Mark

    2014-01-01

    Carl Friedrich von Weizsäcker spanned a spectrum from physics to politics, with philosophy in-between. This chapter surveys the most controversial part of his career, including his work on nuclear weapons and participation in cultural propaganda during the Second World War, his subsequent active political engagement during the postwar Federal German Republic, in particular the role of nuclear weapons, and his participation in myths surrounding Hitler's Bomb".

  7. Charles Darwin and other great men in correspondence with Carl Wilhelm von Naegeli.

    PubMed

    Naegeli, W; Wiedemann, H R

    1993-04-15

    The great Swiss-German botanist Carl Wilhelm von Naegeli (1817-1891) was a student of Lorenz Oken, A.P. de Candolle, and Matthias Jacob Schleiden and became a key figure in "genetic" (i.e., evolutionary-developmental) biology in the mid-late 19th century. He was an expert on the hawk-weed, Hieracium and also made important contributions to microbiology. One of his many outstanding students was Carl Correns, one of the 3 rediscoverers of Mendel's work. Naegeli was an early proponent and defender of Darwin. The correspondence preserved in the Naegeli family contains many important letters between Naegeli and his contemporaries. Those from Mendel to Naegeli have passed out of the Naegeli family and were published by Correns earlier in the century. However, exceptionally notable items still in the archives of the Naegeli family include 4 surviving letters from Darwin, 2 letters from Virchow, and 10 from Justus von Liebig. In spite of a lack of appreciation of Mendel's work, we call attention to the importance of those surviving documents from an era in which very few of the greatest naturalists and founders of modern biology--including Goethe, Darwin, Galton, Agassiz, von Humboldt, von Baer--were without "blind spots."

  8. Charles Darwin and other great men in correspondence with Carl Wilhelm von Naegeli.

    PubMed

    Naegeli, W; Wiedemann, H R

    1993-04-15

    The great Swiss-German botanist Carl Wilhelm von Naegeli (1817-1891) was a student of Lorenz Oken, A.P. de Candolle, and Matthias Jacob Schleiden and became a key figure in "genetic" (i.e., evolutionary-developmental) biology in the mid-late 19th century. He was an expert on the hawk-weed, Hieracium and also made important contributions to microbiology. One of his many outstanding students was Carl Correns, one of the 3 rediscoverers of Mendel's work. Naegeli was an early proponent and defender of Darwin. The correspondence preserved in the Naegeli family contains many important letters between Naegeli and his contemporaries. Those from Mendel to Naegeli have passed out of the Naegeli family and were published by Correns earlier in the century. However, exceptionally notable items still in the archives of the Naegeli family include 4 surviving letters from Darwin, 2 letters from Virchow, and 10 from Justus von Liebig. In spite of a lack of appreciation of Mendel's work, we call attention to the importance of those surviving documents from an era in which very few of the greatest naturalists and founders of modern biology--including Goethe, Darwin, Galton, Agassiz, von Humboldt, von Baer--were without "blind spots." PMID:8484417

  9. Of all foods bread is the most noble: Carl von Linné (Carl Linneaus) on bread1

    PubMed Central

    Räsänen, Leena

    2007-01-01

    Carl von Linné was interested in dietetics, which in his time covered all aspects of a healthy life. As a utilitarian he understood the importance of private economy and paid attention to bread in many of his publications. Two texts, Ceres noverca arctoum and De pane diaetetico, were wholly devoted to bread and bread-making. Linné classified different types of bread, and described their nutritional value and health-related aspects, as well as milling, baking and storing, in detail. While discussing the food habits of social classes Linné accepted as a fact that the peasants and the poor should eat less tasty bread than the rich. The less palatable bread had, however, many nutritional and health advantages. Linné paid much attention to substitutes for grain to be used in times of famine, an important topic in eighteenth century Sweden. He regarded flour made of pine bark or water arum roots as excellent famine food, was enthusiastic about the new plant, maize, but considered potato only as a poor substitute for grain. Linné and his followers praised bread not only as the core component of diet, but also for its versatile role both in health and in disease.

  10. [Carl Friedrich von Weizsäcker: nuclear disarmament and the search for freedom].

    PubMed

    Neuneck, Götz

    2014-01-01

    Carl Friedrich von Weizsäcker's comprehensive contributions to nuclear disarmament and arms control, as well as his peace policy impulses are to be understood primarily in the context of his family origin, his comprehensive thinking and the historical circumstances of the emerging nuclear age. They have a scientific, political and a strong philosophical-moral component. Beside the factual problems (nuclear energy, military strategy) he was interested in political power issues and their ambivalence and perception. His actual work is not only based on general academic knowledge, but also serve the immediate political influence on a scientific basis. Weizsäcker was not committed to nuclear disarmament or arms control per se, but about creating a lasting peace policy in the nuclear age. The paper discusses in chronological order of Weizsäcker's work within the policy field peace and disarmament. Family origin, study and work on the nuclear programme by Nazi-Germany laid the foundations for his later career. As a young physicist, he was directly involved in the political and ethical dilemma of the military and civilian use of nuclear energy. After the war, in Göttingen and Hamburg the reflections of the Nazi phase and the discussion of ways out of the dangers of the Cold War followed. The Max-Planck Institute in Starnberg dealt with the science-based treatment of global world problems, including the dangers of nuclear proliferation. Finally, Weizsäcker initiated a Peace Council in 1985. He urged both the perception of the moral responsibility of scientists as well as an ethics of the scientific-technological age. According to him, a general and profound change in the consciousness of humankind is needed to solve the existing power problems and the problem of war.

  11. [Carl Friedrich von Weizsäcker: nuclear disarmament and the search for freedom].

    PubMed

    Neuneck, Götz

    2014-01-01

    Carl Friedrich von Weizsäcker's comprehensive contributions to nuclear disarmament and arms control, as well as his peace policy impulses are to be understood primarily in the context of his family origin, his comprehensive thinking and the historical circumstances of the emerging nuclear age. They have a scientific, political and a strong philosophical-moral component. Beside the factual problems (nuclear energy, military strategy) he was interested in political power issues and their ambivalence and perception. His actual work is not only based on general academic knowledge, but also serve the immediate political influence on a scientific basis. Weizsäcker was not committed to nuclear disarmament or arms control per se, but about creating a lasting peace policy in the nuclear age. The paper discusses in chronological order of Weizsäcker's work within the policy field peace and disarmament. Family origin, study and work on the nuclear programme by Nazi-Germany laid the foundations for his later career. As a young physicist, he was directly involved in the political and ethical dilemma of the military and civilian use of nuclear energy. After the war, in Göttingen and Hamburg the reflections of the Nazi phase and the discussion of ways out of the dangers of the Cold War followed. The Max-Planck Institute in Starnberg dealt with the science-based treatment of global world problems, including the dangers of nuclear proliferation. Finally, Weizsäcker initiated a Peace Council in 1985. He urged both the perception of the moral responsibility of scientists as well as an ethics of the scientific-technological age. According to him, a general and profound change in the consciousness of humankind is needed to solve the existing power problems and the problem of war. PMID:24974615

  12. [Encounters and re-encounters - philosophy and religion of the physicist Carl Friedrich von Weizsäcker].

    PubMed

    Meyer-Abich, Michael

    2014-01-01

    (1) Quantum theory deals not just with reality but with the physical (scientific) reality of its objects. Carl Friedrich von Weizsäcker understood this to imply that scientific knowledge of objects converges with philosophical knowledge of their objectivity but did not succeed in rounding off physics. (2) We are actors as well as spectators not only in scientific knowledge but in political processes as well, particularly by means of science. It is, therefore, not justified to deny political responsibility even in 'basic research'. Carl Friedrich von Weizsacker identified classical physics as the venture of knowledge without love but believed that this boundary could be transcended. The apparent neutrality of science must not be tolerated by the churches, however. (3) In religion Weizsäcker felt most at home in Buddhist spirituality, this being akin to Christian spirituality which has been more or less lost by the Christian churches. Yet he tried to support his church and to participate in its actions. (4) Lack of love corresponds to an excess of power in the religious critique of science. In both respects Weizsäcker presented the mirror to industrial society but people in general did not recognize their image. The Max-Planck-Society, however, shut up Weizsäcker's "Institute for the study of the conditions of life in the modern world" (Starnberg 1970-1980) as soon as possible. (5) Weizsäcker always refrained from exerting any power except that of reason or truth. According to Lao Tse this is the power least perceived as such. In politics he generally followed the mainstream after once having been tempted to action in 1941/42. His influence on German society was based on his charismatic spirituality.

  13. [Encounters and re-encounters - philosophy and religion of the physicist Carl Friedrich von Weizsäcker].

    PubMed

    Meyer-Abich, Michael

    2014-01-01

    (1) Quantum theory deals not just with reality but with the physical (scientific) reality of its objects. Carl Friedrich von Weizsäcker understood this to imply that scientific knowledge of objects converges with philosophical knowledge of their objectivity but did not succeed in rounding off physics. (2) We are actors as well as spectators not only in scientific knowledge but in political processes as well, particularly by means of science. It is, therefore, not justified to deny political responsibility even in 'basic research'. Carl Friedrich von Weizsacker identified classical physics as the venture of knowledge without love but believed that this boundary could be transcended. The apparent neutrality of science must not be tolerated by the churches, however. (3) In religion Weizsäcker felt most at home in Buddhist spirituality, this being akin to Christian spirituality which has been more or less lost by the Christian churches. Yet he tried to support his church and to participate in its actions. (4) Lack of love corresponds to an excess of power in the religious critique of science. In both respects Weizsäcker presented the mirror to industrial society but people in general did not recognize their image. The Max-Planck-Society, however, shut up Weizsäcker's "Institute for the study of the conditions of life in the modern world" (Starnberg 1970-1980) as soon as possible. (5) Weizsäcker always refrained from exerting any power except that of reason or truth. According to Lao Tse this is the power least perceived as such. In politics he generally followed the mainstream after once having been tempted to action in 1941/42. His influence on German society was based on his charismatic spirituality. PMID:24974621

  14. [Carl Friedrich von Weizsäcker's design of a unity of physics].

    PubMed

    Görnitz, Thomas

    2014-01-01

    As I learned in many conversations with Carl Friedrich von Weizsäcker, he saw his place in the history of science deriving from his "Theory of Urs". This theory will establish the unity of science on the basis of quantum bits. Any attempts to find some "fundamental bricks"--of whatever kind--must fail because of the antinomies of atomism. An abstract quantum bit is a structure quantum that cannot be conceived as a particle in space and time. However, it is clear, solely for logical reasons, that a quantum bit is an ultimate and indecomposable entity. Weizsäcker's revolutionary goal was--already 50 years ago--to unite quantum theory with cosmology and, on these grounds, proceed to a theory of elementary particles. The article gives a short overview of Weizsäcker's approach to the unity of physics, ending with a brief summary of what has been achieved in that endeavour up to now.

  15. [Carl Friedrich von Weizsäcker and the Bethe-Weizsäcker cycle].

    PubMed

    Wiescher, Michael

    2014-01-01

    The Carbon- or Bethe-Weizsäcker Cycle plays an important role in astrophysics as one of the most important energy sources for a quiescent and explosive hydrogen burning in stars. This paper presents the historical background and the contributions by Carl Friedrich von Weizsäcker and Hans Bethe who provided the first predictions of the cycle. Furthermore, it discussed the experimental verification of the predicted process in the following decades. Also discussed is the extension of the initial Carbon cycle to the CNO multi-cycles and the hot CNO cycles which followed from the detailed experimental studies of the associated nuclear reactions. Finally discussed is the impact of the experimental and theoretical results on our present understanding of hydrogen burning in different stellar environments and on our understanding of the chemical evolution of our universe. PMID:24974598

  16. [Carl Friedrich von Weizsäcker and the Bethe-Weizsäcker cycle].

    PubMed

    Wiescher, Michael

    2014-01-01

    The Carbon- or Bethe-Weizsäcker Cycle plays an important role in astrophysics as one of the most important energy sources for a quiescent and explosive hydrogen burning in stars. This paper presents the historical background and the contributions by Carl Friedrich von Weizsäcker and Hans Bethe who provided the first predictions of the cycle. Furthermore, it discussed the experimental verification of the predicted process in the following decades. Also discussed is the extension of the initial Carbon cycle to the CNO multi-cycles and the hot CNO cycles which followed from the detailed experimental studies of the associated nuclear reactions. Finally discussed is the impact of the experimental and theoretical results on our present understanding of hydrogen burning in different stellar environments and on our understanding of the chemical evolution of our universe.

  17. [Carl Friedrich von Weizsäcker's language, rhetoric and habitus].

    PubMed

    Hentschel, Klaus

    2014-01-01

    Carl Friedrich von Weizsäcker was not only an exceptional physicist, philosopher and peace scholar, but also a skilled and articulate speaker and a highly successful author. Dozens of his books were published in tens of thousands of copies despite their highly nontrivial content. This wide impact was only possible--this at least is one of the claims made in this paper--because of his sophisticated style and rhetorics. The analysis here is based on hand-picked samples from all kinds of Weizsäcker texts (talks, scientific and popular papers and books, poems and Limericks). Strangely enough, this interesting stylistic and rhetorical facet of his oeuvre has hitherto not been analyzed in any detail despite its crucial importance in the broad impact on his multifarious audience. My paper starts out from a collection of striking features of his language and structural specialties in his published talks and speeches, and explore findings from sound recordings and film tapes which offer further insight into his manner of emphasis, usage of pauses and intonation. On the basis of these stylistic traits and their often subcutaneous, but nevertheless clever rhetorics, I close with a few remarks on the habitus of this scholar and his positioning within the ensemble of German-speaking physicists of that generation.

  18. [Carl Friedrich von Weizsäcker and the interpretations of quantum theory].

    PubMed

    Stöckler, Manfred

    2014-01-01

    What are 'interpretations' of quantum theory? What are the differences between Carl Friedrich von Weizsäkcker's approach and contemporary views? The various interpretations of quantum mechanics give diverse answers to questions concerning the relation between measuring process and standard time development, the embedding of quantum objects in space ('wave-particle-dualism'), and the reference of state vectors. Does the wave function describe states in the real world or does it refer to our knowledge about nature? First, some relevant conceptions in Weizsäcker's book The Structure of Physics (Der Aufbau der Physik, 1985) are introduced. In a second step I point out why his approach is not any longer present in contemporary debates. One reason is that Weizsäcker is mainly affected by classical philosophy (Platon, Aristoteles, Kant). He could not esteem the philosophy of science that was developed in the spirit of logical empiricism. So he lost interest in disputes with Anglo-Saxon philosophy of quantum mechanics. Especially his interpretation of probability and his analysis of the collapse of the state function as change in knowledge differ from contemporary standard views. In recent years, however, epistemic interpretations of quantum mechanics are proposed that share some of Weizsäcker's intuitions.

  19. [Carl Friedrich von Weizsäcker's language, rhetoric and habitus].

    PubMed

    Hentschel, Klaus

    2014-01-01

    Carl Friedrich von Weizsäcker was not only an exceptional physicist, philosopher and peace scholar, but also a skilled and articulate speaker and a highly successful author. Dozens of his books were published in tens of thousands of copies despite their highly nontrivial content. This wide impact was only possible--this at least is one of the claims made in this paper--because of his sophisticated style and rhetorics. The analysis here is based on hand-picked samples from all kinds of Weizsäcker texts (talks, scientific and popular papers and books, poems and Limericks). Strangely enough, this interesting stylistic and rhetorical facet of his oeuvre has hitherto not been analyzed in any detail despite its crucial importance in the broad impact on his multifarious audience. My paper starts out from a collection of striking features of his language and structural specialties in his published talks and speeches, and explore findings from sound recordings and film tapes which offer further insight into his manner of emphasis, usage of pauses and intonation. On the basis of these stylistic traits and their often subcutaneous, but nevertheless clever rhetorics, I close with a few remarks on the habitus of this scholar and his positioning within the ensemble of German-speaking physicists of that generation. PMID:24974596

  20. [Carl Friedrich von Weizsäcker and the interpretations of quantum theory].

    PubMed

    Stöckler, Manfred

    2014-01-01

    What are 'interpretations' of quantum theory? What are the differences between Carl Friedrich von Weizsäkcker's approach and contemporary views? The various interpretations of quantum mechanics give diverse answers to questions concerning the relation between measuring process and standard time development, the embedding of quantum objects in space ('wave-particle-dualism'), and the reference of state vectors. Does the wave function describe states in the real world or does it refer to our knowledge about nature? First, some relevant conceptions in Weizsäcker's book The Structure of Physics (Der Aufbau der Physik, 1985) are introduced. In a second step I point out why his approach is not any longer present in contemporary debates. One reason is that Weizsäcker is mainly affected by classical philosophy (Platon, Aristoteles, Kant). He could not esteem the philosophy of science that was developed in the spirit of logical empiricism. So he lost interest in disputes with Anglo-Saxon philosophy of quantum mechanics. Especially his interpretation of probability and his analysis of the collapse of the state function as change in knowledge differ from contemporary standard views. In recent years, however, epistemic interpretations of quantum mechanics are proposed that share some of Weizsäcker's intuitions. PMID:24974602

  1. [A failed experiment - Carl Friedrich von Weizsäcker, Jürgen Habermas and the Max-Planck Society].

    PubMed

    Leendertz, Ariane

    2014-01-01

    From 1970 to 1980 Carl Friedrich von Weizsäcker headed the Max-Planck-lnstitut zur Erforschung der Lebensbedingungen der wissenschaftlich-technischen Welt (MPI for the study of the living conditions of the world of science and technology) in Starnberg, jointly with Jürgen Habermas since 1971. From the start, the Max Planck Society regarded the new institute as an experiment that might perhaps be aborted a few years later. This is exactly what happened. With the retirement of Weizsäcker, his section was closed and the whole institute was renamed. In 1981. Habermas resigned, and then the institute was closed. This paper focusses on some of the problem constellations within the institute that partly explain its development and eventual closure: its birth out of the idea of scientific policy advice, the debates within the Max Planck Society and the complex relationship between Weizsäcker and Jürgen Habermas.

  2. [A utopian episode - Carl Friedrich von Weizsäcker in the networks of the Max-Planck Society].

    PubMed

    Kant, Horst; Renn, Jürgen

    2014-01-01

    Carl Friedrich von Weizsäcker was a key figure in the history of the Max Planck Society (MPS). This essay contextualises his work with the development of the MPS, highlighting the institutional and personal networks upon which it was based. Some of the stations addressed in the following are his role in the German Uranium Project, in preparing the Mainau Declaration, the Göttingen Manifesto, and the Memorandum of Tübingen as well as his involvement in the foundation of the Max Planck Institute (MPI) for Human Development and his own MPI for the Research of Living Conditions in the Modern World located in Starnberg. The relationship between Weizsäcker and Hellmut Becker, long-time friend and founding director of the MPI for Human Development, will be of particular interest. Another issue broached here is the connection between natural science and the humanities in Weizsäcker's work, and subsequently the relation between these two science cultures in the MPS. Finally, we look at the challenges Weizsäcker's work could present to the MPS today.

  3. [Living with responsibility: Max Born and Carl Friedrich von Weizsäcker as philosophers with distance].

    PubMed

    Schirrmacher, Arne

    2014-01-01

    Both Carl Friedrich von Weizsäcker und Max Born belong to the most active scientists, which have raised their voice for peace in the 1950s. While Born, senior to Weizsäcker by one generation, engaged in peace movements at an early stage, which was also due to his emigration, and was a driving force for the Einstein-Russell memorandum, Weizsäcker entered the stage essentially with the Göttingen declaration but quickly dominated the discourse. The comparison of their different engagements for peace sheds new light on Weizsäcker. Unlike the German emigrant with a British passport, who was mainly influenced by EInstein and Russell as well as some socialist thoughts he had encountered at an early age, the son of a noble diplomat and the physicist, who was saved from military duties because of his work in the German wartime nuclear project, had quite a different perspective on the postwar atomic threat. The relation of Born and Weizsäcker remained marked by a certain distance even when both took up very similar roles of 'public scientists' active for peace, be it as delegates at Pugwash conferences, on the air, or as speakers in the Frankfurt Paulskirche.

  4. [Living with responsibility: Max Born and Carl Friedrich von Weizsäcker as philosophers with distance].

    PubMed

    Schirrmacher, Arne

    2014-01-01

    Both Carl Friedrich von Weizsäcker und Max Born belong to the most active scientists, which have raised their voice for peace in the 1950s. While Born, senior to Weizsäcker by one generation, engaged in peace movements at an early stage, which was also due to his emigration, and was a driving force for the Einstein-Russell memorandum, Weizsäcker entered the stage essentially with the Göttingen declaration but quickly dominated the discourse. The comparison of their different engagements for peace sheds new light on Weizsäcker. Unlike the German emigrant with a British passport, who was mainly influenced by EInstein and Russell as well as some socialist thoughts he had encountered at an early age, the son of a noble diplomat and the physicist, who was saved from military duties because of his work in the German wartime nuclear project, had quite a different perspective on the postwar atomic threat. The relation of Born and Weizsäcker remained marked by a certain distance even when both took up very similar roles of 'public scientists' active for peace, be it as delegates at Pugwash conferences, on the air, or as speakers in the Frankfurt Paulskirche. PMID:24974612

  5. [A utopian episode - Carl Friedrich von Weizsäcker in the networks of the Max-Planck Society].

    PubMed

    Kant, Horst; Renn, Jürgen

    2014-01-01

    Carl Friedrich von Weizsäcker was a key figure in the history of the Max Planck Society (MPS). This essay contextualises his work with the development of the MPS, highlighting the institutional and personal networks upon which it was based. Some of the stations addressed in the following are his role in the German Uranium Project, in preparing the Mainau Declaration, the Göttingen Manifesto, and the Memorandum of Tübingen as well as his involvement in the foundation of the Max Planck Institute (MPI) for Human Development and his own MPI for the Research of Living Conditions in the Modern World located in Starnberg. The relationship between Weizsäcker and Hellmut Becker, long-time friend and founding director of the MPI for Human Development, will be of particular interest. Another issue broached here is the connection between natural science and the humanities in Weizsäcker's work, and subsequently the relation between these two science cultures in the MPS. Finally, we look at the challenges Weizsäcker's work could present to the MPS today. PMID:24974604

  6. [Living without atomic power? Carl Friedrich von Weizsäcker as expert in the nuclear energy debate of the 1970's].

    PubMed

    Seefried, Elke

    2014-01-01

    Carl Friedrich von Weizsäcker crossed the boundaries separating science, politics and the public sphere. In this he was led by the conviction that scientists in the modern 'technical age' are responsible for consequences resulting from their applied knowledge. Weizsäcker tried to introduce his knowledge into the policy process by advising politicians or by using the public sphere, thus applying pressure on politics. This was not only true for the 'Göttinger Erklärung' in 1957 but also for his engagement in the nuclear energy debate of the 1970s. Influenced by the 'Limits to Growth' discourse, Weizsäcker more and more gravitated towards an ecological world view and increasingly questioned material growth as well as a techno-scientific based understanding of progress. Weizsäcker thought about risks of the technical age in general and of the use of nuclear energy in particular. In the light of a growing fragmentation of scientific authority, Weizsäcker revealed uncertainty as he became fully aware that expertise cannot be based on scientific reason and cannot code the problems in terms of truth, but is inextricably linked with value spheres and contingencies. Nevertheless, his expertise was utilized as he encouraged parts of the Social Democratic Party (SPD) around Erhard Eppler to think about alternatives in energy policy. PMID:24974614

  7. ["World domestic policy" as a way to eternal peace? Carl Friedrich von Weizsäcker's realistic idealism as theory of a sustainable policy].

    PubMed

    Bartosch, Ulrich

    2014-01-01

    The intention of this article is to show the suitability of "Weltinnenpolitik" (world domestic policy) as an analytic and programmatic view on contemporary policy. A full reconstruction or comparison of Carl Friedrich von Weizsäcker's concept is not at the focus. As mentioned in other contributions to this volume, Weizsäcker did not refer to the disciplinary discourses in detail. His approach is particularly 'unique' since he set about in 1963 to study the conditions of peace in a very general way. By doing so, he was able to circumscribe the conditions of peace realistically: those valid for us today and apparently also in the future. Weizsäcker probably did underestimate the complexity of the transformation to sustainable politics for preventing climate change. Vice versa one should hope that we today do not discount the prevention of atomic war as a sine qua non for sustainable climate-saving policy. Both could mark the quintessential conditions for peace. PMID:24974610

  8. [Living without atomic power? Carl Friedrich von Weizsäcker as expert in the nuclear energy debate of the 1970's].

    PubMed

    Seefried, Elke

    2014-01-01

    Carl Friedrich von Weizsäcker crossed the boundaries separating science, politics and the public sphere. In this he was led by the conviction that scientists in the modern 'technical age' are responsible for consequences resulting from their applied knowledge. Weizsäcker tried to introduce his knowledge into the policy process by advising politicians or by using the public sphere, thus applying pressure on politics. This was not only true for the 'Göttinger Erklärung' in 1957 but also for his engagement in the nuclear energy debate of the 1970s. Influenced by the 'Limits to Growth' discourse, Weizsäcker more and more gravitated towards an ecological world view and increasingly questioned material growth as well as a techno-scientific based understanding of progress. Weizsäcker thought about risks of the technical age in general and of the use of nuclear energy in particular. In the light of a growing fragmentation of scientific authority, Weizsäcker revealed uncertainty as he became fully aware that expertise cannot be based on scientific reason and cannot code the problems in terms of truth, but is inextricably linked with value spheres and contingencies. Nevertheless, his expertise was utilized as he encouraged parts of the Social Democratic Party (SPD) around Erhard Eppler to think about alternatives in energy policy.

  9. ["World domestic policy" as a way to eternal peace? Carl Friedrich von Weizsäcker's realistic idealism as theory of a sustainable policy].

    PubMed

    Bartosch, Ulrich

    2014-01-01

    The intention of this article is to show the suitability of "Weltinnenpolitik" (world domestic policy) as an analytic and programmatic view on contemporary policy. A full reconstruction or comparison of Carl Friedrich von Weizsäcker's concept is not at the focus. As mentioned in other contributions to this volume, Weizsäcker did not refer to the disciplinary discourses in detail. His approach is particularly 'unique' since he set about in 1963 to study the conditions of peace in a very general way. By doing so, he was able to circumscribe the conditions of peace realistically: those valid for us today and apparently also in the future. Weizsäcker probably did underestimate the complexity of the transformation to sustainable politics for preventing climate change. Vice versa one should hope that we today do not discount the prevention of atomic war as a sine qua non for sustainable climate-saving policy. Both could mark the quintessential conditions for peace.

  10. [The alphabet of nature and the alphabet of culture in the eighteenth century. botany, diplomatics, and ethno-linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner : Botany, Diplomatics, and ethno-linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner].

    PubMed

    Gierl, Martin

    2010-01-01

    In the middle of the eighteenth century, Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner attempted to realize the old idea of deciphering the alphabet of the world, which Francis Bacon had raised as a general postulate of science. This article describes these attempts and their interrelations. Linné used the model of the alphabet to classify plants according to the characters of this fruiting body. Gatterer, one of the leading German historians during the Enlightenment, adopted the botanical method of classification by genus and species to classify the history of scripts. He used the forms of the alphabetic characters to measure the age of manuscripts and to map the process of history as a genealogy of culture. Gatterer collaborated closely with Büttner, the first Göttingen professor of natural history. Büttner constructed a general alphabet of languages which connected the phonetics of language with the historically known alphabets. Early on, diplomatics and ethnography combined the natural order of natural history and the cultural order of the alphabet with the attempt to register development and to document development by the evolution of forms. Based on the shared model of the alphabet and on the common necessity to classify their empirical material, natural history and the description of culture were related attempts in the middle of the eighteenth century to comprehend the alphabetically organized nature and a naturally ordered culture. PMID:20665241

  11. [The alphabet of nature and the alphabet of culture in the eighteenth century. botany, diplomatics, and ethno-linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner : Botany, Diplomatics, and ethno-linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner].

    PubMed

    Gierl, Martin

    2010-01-01

    In the middle of the eighteenth century, Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner attempted to realize the old idea of deciphering the alphabet of the world, which Francis Bacon had raised as a general postulate of science. This article describes these attempts and their interrelations. Linné used the model of the alphabet to classify plants according to the characters of this fruiting body. Gatterer, one of the leading German historians during the Enlightenment, adopted the botanical method of classification by genus and species to classify the history of scripts. He used the forms of the alphabetic characters to measure the age of manuscripts and to map the process of history as a genealogy of culture. Gatterer collaborated closely with Büttner, the first Göttingen professor of natural history. Büttner constructed a general alphabet of languages which connected the phonetics of language with the historically known alphabets. Early on, diplomatics and ethnography combined the natural order of natural history and the cultural order of the alphabet with the attempt to register development and to document development by the evolution of forms. Based on the shared model of the alphabet and on the common necessity to classify their empirical material, natural history and the description of culture were related attempts in the middle of the eighteenth century to comprehend the alphabetically organized nature and a naturally ordered culture.

  12. ["The hard core". Science between politics and philosophy by Carl Friedrich von Weizsäcker and in the finalization theory].

    PubMed

    Krohn, Wolfgang

    2014-01-01

    In the Starnberg Max-Planck Institute one of the working groups was concerned with science as the formative condition--or "hard core"--of societal modernity, and with science as potential resource for solving social problems and addressing future goals. More precisely, the group intended to differentiate between phases in which scientific disciplines predominantly care for their own paradigmatic completion and those allowing their theoretical potential resonate with external needs. The conceptual model was coined "finalization in science". It soon provoked a heated controversy on the dangers of social control of science. The paper analyses Carl Friedrich von Weizsäcker's views on the relation between philosophy and policy of science including his interpretation of Thomas Kuhn and reconstructs the impact of his ideas on the finalization model. It finally reflects on the relationship between science development and change of consciousness in the context of scientific responsibility for (the use of) research outcomes.

  13. [The "utopian" national socialism - a mutual dispute in the philosophy of Martin Heidegger and Carl Friedrich von Weizsäcker?].

    PubMed

    Schäfer, Wolf

    2014-01-01

    In a letter to his wife from October 14, 1943, Werner Heisenberg describes a fierce clash with Carl Friedrich von Weizsäcker. The sudden conflict raises numerous questions, two of which are tackled here. First: How is now the friendly relationship between Heisenberg and Weizsäcker in the postwar years to be understood? The answer is: as a strategic performance. Second: How are the radical opinions to be explained that Weizsäcker expressed at the time? A thorough reconstruction of the lifelong connection that Weizsäcker maintained with Martin Heidegger and Heidegger's philosophy gives the answer: the young Weizsäcker was fired up by the "utopian" National Socialism with which Heidegger trumped the real existing. PMID:24974620

  14. [The "utopian" national socialism - a mutual dispute in the philosophy of Martin Heidegger and Carl Friedrich von Weizsäcker?].

    PubMed

    Schäfer, Wolf

    2014-01-01

    In a letter to his wife from October 14, 1943, Werner Heisenberg describes a fierce clash with Carl Friedrich von Weizsäcker. The sudden conflict raises numerous questions, two of which are tackled here. First: How is now the friendly relationship between Heisenberg and Weizsäcker in the postwar years to be understood? The answer is: as a strategic performance. Second: How are the radical opinions to be explained that Weizsäcker expressed at the time? A thorough reconstruction of the lifelong connection that Weizsäcker maintained with Martin Heidegger and Heidegger's philosophy gives the answer: the young Weizsäcker was fired up by the "utopian" National Socialism with which Heidegger trumped the real existing.

  15. Director von Braun Presents General Medaris With Golf Bag

    NASA Technical Reports Server (NTRS)

    1959-01-01

    Marshall Space Flight Center Director Wernher von Braun presents General J.B. Medaris with a new golf bag. General Medaris, (left) was a Commander of the Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama during 1955 to 1958.

  16. Carl Friedrich Gauss - General Theory of Terrestrial Magnetism - a revised translation of the German text

    NASA Astrophysics Data System (ADS)

    Glassmeier, K.-H.; Tsurutani, B. T.

    2014-02-01

    This is a translation of the Allgemeine Theorie des Erdmagnetismus published by Carl Friedrich Gauss in 1839 in the Resultate aus den Beobachtungen des Magnetischen Vereins im Jahre 1838. The current translation is based on an earlier translation by Elizabeth Juliana Sabine published in 1841. This earlier translation has been revised, corrected, and extended. Numerous biographical comments on the scientists named in the original text have been added as well as further information on the observational material used by Carl Friedrich Gauss. An attempt is made to provide a readable text to a wider scientific community, a text laying the foundation of today's understanding of planetary magnetic fields.

  17. The Alphabet of Nature and the Alphabet of Culture in the Eighteenth Century. Botany, Diplomatics, and Ethno-Linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner

    PubMed Central

    2010-01-01

    In the middle of the eighteenth century, Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner attempted to realize the old idea of deciphering the alphabet of the world, which Francis Bacon had raised as a general postulate of science. This article describes these attempts and their interrelations. Linné used the model of the alphabet to classify plants according to the characters of this fruiting body. Gatterer, one of the leading German historians during the Enlightenment, adopted the botanical method of classification by genus and species to classify the history of scripts. He used the forms of the alphabetic characters to measure the age of manuscripts and to map the process of history as a genealogy of culture. Gatterer collaborated closely with Büttner, the first Göttingen professor of natural history. Büttner constructed a general alphabet of languages which connected the phonetics of language with the historically known alphabets. Early on, diplomatics and ethnography combined the natural order of natural history and the cultural order of the alphabet with the attempt to register development and to document development by the evolution of forms. Based on the shared model of the alphabet and on the common necessity to classify their empirical material, natural history and the description of culture were related attempts in the middle of the eighteenth century to comprehend the alphabetically organized nature and a naturally ordered culture. PMID:20665241

  18. From the classical to the generalized von Karman and Marguerre-von Karman equations

    NASA Astrophysics Data System (ADS)

    Ciarlet, Philippe G.; Gratie, Liliana

    2006-06-01

    In this work, we describe and analyze two models that were recently proposed for modeling generalized von Karman plates and generalized Marguerre-von Karman shallow shells.First, we briefly review the "classical" von Karman and Marguerre-von Karman equations, their physical meaning, and their mathematical justification. We then consider the more general situation where only a portion of the lateral face of a nonlinearly elastic plate or shallow shell is subjected to boundary conditions of von Karman type, while the remaining portion is free. Using techniques from formal asymptotic analysis, we obtain in each case a two-dimensional boundary value problem that is analogous to, but is more general than, the classical equations.In particular, it is remarkable that the boundary conditions for the Airy function can still be determined on the entire boundary of the nonlinearly elastic plate or shallow shell solely from the data.Following recent joint works, we then reduce these more general equations to a single "cubic" operator equation, which generalizes an equation introduced by Berger and Fife, and whose sole unknown is the vertical displacement of the shell. We next adapt an elegant compactness method due to Lions for establishing the existence of a solution to this operator equation.

  19. Carl Woese

    PubMed Central

    Moore, Peter B

    2014-01-01

    Not long after Carl Woese died, I received a message from Robin Gutell asking if I would contribute an article to this issue of RNA Biology. While my admiration for Carl’s contributions to biology knows no bounds, I did not know him well personally. For that reason I advised Robin to strike my name off the list of contributors and replace it with that of someone who is better qualified than I am, but he persisted, and here we are. I guess Robin thought it would be useful to hear from one of those who admired Carl from afar. The naïve outsider might find it surprising that a structural biologist like me, who worries about the minutia of the three-dimensional structures of biological macromolecules, would ever have had anything in common with a big-picture, evolutionary biologist like Carl, but I did. What we shared was an interest in the structures of RNAs, especially rRNAs. PMID:24598315

  20. Carl Sagan Cosmos Voyager

    NASA Video Gallery

    Excerpt from "Cosmos", read by Carl Sagan, part of the NASA.gov multimedia piece celebrating NASA's 50th anniversary in 2008. Used by permission of Carl Sagan Associates. To see the whole interacti...

  1. 16. Historic American Buildings Survey, Carl F. Waite, Photographer April, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Historic American Buildings Survey, Carl F. Waite, Photographer April, 1934 INTERIOR, GENERAL VIEW LOOKING WEST, SECOND FLOOR - Kirtland Temple (Mormon), 9020 Chillicoth Road, Kirtland, Lake County, OH

  2. Stochastic resonance in a generalized Von Foerster population growth model

    SciTech Connect

    Lumi, N.; Mankin, R.

    2014-11-12

    The stochastic dynamics of a population growth model, similar to the Von Foerster model for human population, is studied. The influence of fluctuating environment on the carrying capacity is modeled as a multiplicative dichotomous noise. It is established that an interplay between nonlinearity and environmental fluctuations can cause single unidirectional discontinuous transitions of the mean population size versus the noise amplitude, i.e., an increase of noise amplitude can induce a jump from a state with a moderate number of individuals to that with a very large number, while by decreasing the noise amplitude an opposite transition cannot be effected. An analytical expression of the mean escape time for such transitions is found. Particularly, it is shown that the mean transition time exhibits a strong minimum at intermediate values of noise correlation time, i.e., the phenomenon of stochastic resonance occurs. Applications of the results in ecology are also discussed.

  3. [Carl Friedrich von Weizsäcker - supporter of the concept of the East German movement in favor of self-organization during the political turning point 1989/90].

    PubMed

    Gebhardt, Gerd

    2014-01-01

    The luminosity of Carl Friedrich von Weizsäcker's holistic thinking in the former German Democratic Republic (DDR) is reviewed. Broad-minded academics sought, in accordance with the modern paradigm of self-organization, beyond the ideological template for ways out of the dead end of incrustations of society and innovation blockages under the constraints of a dictatorship. Right after the fall of the wall, Weizsäcker willingly backed a "community of free researchers for self-organization" (Freie Forschungsgemeinschaft Selbstorganisation, FFGSO). This group, conceived as a nonpartisan "think tank" of civil activism, is also discussed. At a number of its meetings Weizsäcker debated the dangers of ideologically influenced science. The effectiveness of the dual leadership at his own Starnberg Institute, for instance, was stymied by the tensions arisen out of such conflicting aims. Against the voluntaristic anticipations of the mainstream in sociology, precisely that system proved to be more viable that was meant to be overcome: faulty and purportedly futureless capitalism. Weizsäcker repudiated social prognoses made in the absence of rules for their falsification resp. verification. Weizsäcker acted as a leading figure at the FFGSO's Potsdam conference, opened on 30 Mar. 1990, on the "DDR--and afterwards?". Its intention was in order to trigger a nationwide discussion of scientific scenarios in designing German unification in the face of gross practical disparities between East and West Germany. The Trust Agency inspired by the FFGSO at the Round Table between opposition and old government was supposed to transfer the national public property "Volkseigentum" of the DDR into private property of the East German citizens, to enable them to realize a role as subject through self-organization. At the group's request, Weizsäcker mediated the readiness by the Lutheran World Federation to assume the role of ombudsman in anticipation of conflicts of interest within the

  4. [Carl Friedrich von Weizsäcker - supporter of the concept of the East German movement in favor of self-organization during the political turning point 1989/90].

    PubMed

    Gebhardt, Gerd

    2014-01-01

    The luminosity of Carl Friedrich von Weizsäcker's holistic thinking in the former German Democratic Republic (DDR) is reviewed. Broad-minded academics sought, in accordance with the modern paradigm of self-organization, beyond the ideological template for ways out of the dead end of incrustations of society and innovation blockages under the constraints of a dictatorship. Right after the fall of the wall, Weizsäcker willingly backed a "community of free researchers for self-organization" (Freie Forschungsgemeinschaft Selbstorganisation, FFGSO). This group, conceived as a nonpartisan "think tank" of civil activism, is also discussed. At a number of its meetings Weizsäcker debated the dangers of ideologically influenced science. The effectiveness of the dual leadership at his own Starnberg Institute, for instance, was stymied by the tensions arisen out of such conflicting aims. Against the voluntaristic anticipations of the mainstream in sociology, precisely that system proved to be more viable that was meant to be overcome: faulty and purportedly futureless capitalism. Weizsäcker repudiated social prognoses made in the absence of rules for their falsification resp. verification. Weizsäcker acted as a leading figure at the FFGSO's Potsdam conference, opened on 30 Mar. 1990, on the "DDR--and afterwards?". Its intention was in order to trigger a nationwide discussion of scientific scenarios in designing German unification in the face of gross practical disparities between East and West Germany. The Trust Agency inspired by the FFGSO at the Round Table between opposition and old government was supposed to transfer the national public property "Volkseigentum" of the DDR into private property of the East German citizens, to enable them to realize a role as subject through self-organization. At the group's request, Weizsäcker mediated the readiness by the Lutheran World Federation to assume the role of ombudsman in anticipation of conflicts of interest within the

  5. Carl Woese in Schenectady

    PubMed Central

    Gold, Larry

    2014-01-01

    Many of the authors of these short pieces (who were invited to contribute by Robin Gutell) have already written or spoken about Carl Woese since he died at the end of December 2012. My own thoughts were published in PNAS on February 26, 2013. Still saddened by Carl’s death, I re-read what I wrote at that moment. The article was OK, although it was not strong enough for what Carl taught us: he deserved better. I’d like us to admire what Carl did over 50 years (which is a given), and to admire even more the way he did it. While Carl’s accomplishments were huge, his intense dedication to the ideas that consumed him was even more impressive. PMID:24736618

  6. Carl Friedrich Gauss

    ERIC Educational Resources Information Center

    Rice, Kathryn; Scott, Paul

    2005-01-01

    This article presents a brief biography of Johann Carl Friedrich Gauss. Gauss was born on April 30, 1777, in the German city of Braunschweig (Brunswick). He was the only child of Gebhard Dietrich Gauss and Dorothea Benze. Neither of Gauss's parents had much education, his father could read and write, but earned his living doing menial jobs such as…

  7. Carl Sagan's Universe

    NASA Astrophysics Data System (ADS)

    Terzian, Yervant; Bilson, Elizabeth

    1997-10-01

    Preface; Carl Sagan at sixty; Part I. Planetary Exploration: 1. On the occasion of Carl Sagan's sixtieth birthday Wesley T. Huntress, Jr.; 2. The search for the origins of life: U.S. Solar system exploration, 1962-1994 Edward C. Stone; 3. Highlights of the Russian planetary program Roald Sageev; 4. From the eyepiece to the footpad: The search for life on Mars Bruce Murray; Part II. Life in the Cosmos: 5. Environments of Earth and other worlds Owen B. Toon; 6. The origin of life in a cosmic context Christopher F. Chyba; 7. Impacts and life: Living in a risky planetary system David Morrison; 8. Extraterrestrial intelligence: The significance of the search Frank D. Drake; 9. Extraterrestrial intelligence: The search programs Paul Horowitz; 10. Do the laws of physics permit wormholes for interstellar travel and machines for time travel? Kip S. Thorne; Public Address: 11. The age of exploration Carl Sagan; Part III. Science Education: 12. Does science need to be popularized? Ann Druyen; 13. Science and pseudo-science James Randi; 14. Science education in a democracy Philip Morrison; 15. The visual presentation of science Jon Lomberg; 16. Science and the press Walter Anderson; 17. Science and teaching Bill G. Aldridge; Part IV. Science, Environment and Public Policy: 18. The relationship of science and power Richard L. Garwin; 19. Nuclear-free world? Georgi Arbatov; 20. Carl Sagan and nuclear winter Richard P. Turco; 21. Public understanding of global climate change James Hansen; 22. Science and religion Joan B. Campbell; 23. Speech in honor of Carl Sagan Frank Press.

  8. Carl Rogers: Reflections on His Life.

    ERIC Educational Resources Information Center

    Heppner, P. Paul; And Others

    1984-01-01

    Interviewed Carl Rogers, a prominent psychologist, about aspects of his personal life, professional contributions, significant others, and psychology in general. Includes excerpts from several letters from individuals who have known Rogers and who were asked to comment on their experiences with him. (LLL)

  9. A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia.

    PubMed

    Guerreiro de Moura, Carlos Antônio Gusmão; de Assis, Luiz Henrique; Góes, Paulo; Rosa, Fabiana; Nunes, Victor; Gusmão, Ítalo Magalhães; Cruz, Constança Margarida Sampaio

    2015-01-01

    Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the annular form. GPP may also present severe extracutaneous manifestations including pneumonitis, heart failure and hepatitis. Old reports showed a relationship between hypoparathyroidism and hypocalcemia as triggers for GPP highlighting the importance of adequate workup of the patient and possible therapeutic changes in acute situations. Here, we present a case of severe von Zumbusch psoriasis with life-threatening complications triggered by severe hypocalcemia secondary to hypoparathyroidism successfully treated with aggressive calcium reposition. PMID:26955330

  10. A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia

    PubMed Central

    Guerreiro de Moura, Carlos Antônio Gusmão; de Assis, Luiz Henrique; Góes, Paulo; Rosa, Fabiana; Nunes, Victor; Gusmão, Ítalo Magalhães; Cruz, Constança Margarida Sampaio

    2015-01-01

    Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the annular form. GPP may also present severe extracutaneous manifestations including pneumonitis, heart failure and hepatitis. Old reports showed a relationship between hypoparathyroidism and hypocalcemia as triggers for GPP highlighting the importance of adequate workup of the patient and possible therapeutic changes in acute situations. Here, we present a case of severe von Zumbusch psoriasis with life-threatening complications triggered by severe hypocalcemia secondary to hypoparathyroidism successfully treated with aggressive calcium reposition. PMID:26955330

  11. On the history of Ludwig von Bertalanffy's "general systemology", and on its relationship to cybernetics - Part II: Contexts and developments of the systemological hermeneutics instigated by von Bertalanffy

    NASA Astrophysics Data System (ADS)

    Pouvreau, David

    2014-02-01

    The history of "general system theory" is investigated in order to clarify its meanings, vocations, foundations and achievements. It is characterized as the project of a science of the systemic interpretation of the "real", renamed here "general systemology". The contexts and modes of its elaboration, publication and implementation are discussed. The paper mostly focuses on the works of its instigator: Ludwig von Bertalanffy. However, general systemology was a collective project: the main contributions of other "systemologists", from the 1950s until the 1970s, are hence also considered. Its solidarity with the history of the Society for General Systems Research is notably discussed. A reconstruction of the systemological hermeneutics is undertaken on this basis. It finds out the potential systematic unity underlying the diversity of the contributions to this both scientific and philosophical project. Light is thus shed on the actual scope of von Bertalanffy's works.

  12. A diffusion process to model generalized von Bertalanffy growth patterns: fitting to real data.

    PubMed

    Román-Román, Patricia; Romero, Desirée; Torres-Ruiz, Francisco

    2010-03-01

    The von Bertalanffy growth curve has been commonly used for modeling animal growth (particularly fish). Both deterministic and stochastic models exist in association with this curve, the latter allowing for the inclusion of fluctuations or disturbances that might exist in the system under consideration which are not always quantifiable or may even be unknown. This curve is mainly used for modeling the length variable whereas a generalized version, including a new parameter b > or = 1, allows for modeling both length and weight for some animal species in both isometric (b = 3) and allometric (b not = 3) situations. In this paper a stochastic model related to the generalized von Bertalanffy growth curve is proposed. This model allows to investigate the time evolution of growth variables associated both with individual behaviors and mean population behavior. Also, with the purpose of fitting the above-mentioned model to real data and so be able to forecast and analyze particular characteristics, we study the maximum likelihood estimation of the parameters of the model. In addition, and regarding the numerical problems posed by solving the likelihood equations, a strategy is developed for obtaining initial solutions for the usual numerical procedures. Such strategy is validated by means of simulated examples. Finally, an application to real data of mean weight of swordfish is presented.

  13. Irradiance scintillation index for Gaussian beam based on the generalized anisotropic von Karman spectrum

    NASA Astrophysics Data System (ADS)

    Cui, Linyan

    2016-07-01

    Experiments and theoretical investigations have shown that the atmosphere turbulence exhibits both anisotropic and non-Kolmogorov properties. In this paper, based on the anisotropic generalized von Karman spectrum and the Rytov approximation theory, new expression for the irradiance scintillation index of optical waves is derived for Gaussian beam propagating through weak anisotropic non-Kolmogorov turbulence. Compared with previously published results, it considers simultaneously the asymmetry property of turbulence cells or eddies in the orthogonal xy-plane, the general spectral power law in the range 3-4 instead of constant value of 11/3 for the Kolmogorov turbulence, and the finite turbulence inner and outer scales. Two anisotropic factors are introduced to parameterize the anisotropy of turbulence cells or eddies in horizontal and vertical directions. In the special cases of these two anisotropic factors equaling one and the finite turbulence inner and outer scales equaling separately zero and infinite, the derived expression can reduce correctly to the previously published results. Calculations are performed to analyze the derived results.

  14. Carl Thoresen: The Evolving Pioneer

    ERIC Educational Resources Information Center

    Harris, Alex H. S.

    2009-01-01

    This interview with Carl E. Thoresen highlights the experiences, relationships, and ideas that have influenced this pioneering psychologist throughout the past half century. His scholarly work, professional service, teaching, and mentorship have motivated many counseling psychologists to radically expand their areas of inquiry. He was among the…

  15. Carl Sagan (1934-1996)

    NASA Astrophysics Data System (ADS)

    Chyba, Christopher

    Carl Sagan, Professor of Astronomy and Space Sciences at Cornell University and past AGU Planetology Section president, died of pneumonia on December 20, 1996, following a two-year battle with the bone-marrow disease, myelodysplasia. Sagan, a planetary scientist of the first rank, was also well known for his exceptional skills in bringing science to policymakers and the public. Following a broad undergraduate education with a degree in humanities and physics from the University of Chicago, Carl received his Ph.D. in astronomy and astrophysics from that institution in 1960. He quickly established himself as a pioneer in the investigation of the prospect for extraterrestrial life. His wide background in a variety of sciences, including a position as Visiting Assistant Professor of Genetics at the Stanford University School of Medicine, prepared him well for this new, interdisciplinary field. (Carl's first scientific publication, in 1957, had been “Radiation and the origin of the gene,” in the journal Evolution.) In 1968, Carl came to Cornell University as director of the Laboratory for Planetary Studies, heading a research group that combined spacecraft and theoretical expertise with laboratory investigations of solar system and interstellar organic chemistry.

  16. Grandma Moses Meets Eric Carle

    ERIC Educational Resources Information Center

    Sutley, Jane

    2012-01-01

    This activity features artwork by "Grandma Moses" in which children will learn the picture plane in terms of foreground, middle ground, and background. The teacher also introduces the children to Eric Carle's colorful collaged images in his books. Using the two artists' methods, children experimented and invented new techniques and colors. As the…

  17. Carl Linnaeus: pictures and propaganda.

    PubMed

    Fara, Patricia

    2003-03-01

    How do scientists become famous? Carl Linnaeus was an expert at self-promotion who used portraits to gain patronage and consolidate his reputation. His sexualized classification system was hugely controversial, yet his successors celebrated him as a great hero of botany.

  18. Generalization of von Neumann analysis for a model of two discrete half-spaces: The acoustic case

    USGS Publications Warehouse

    Haney, M.M.

    2007-01-01

    Evaluating the performance of finite-difference algorithms typically uses a technique known as von Neumann analysis. For a given algorithm, application of the technique yields both a dispersion relation valid for the discrete time-space grid and a mathematical condition for stability. In practice, a major shortcoming of conventional von Neumann analysis is that it can be applied only to an idealized numerical model - that of an infinite, homogeneous whole space. Experience has shown that numerical instabilities often arise in finite-difference simulations of wave propagation at interfaces with strong material contrasts. These interface instabilities occur even though the conventional von Neumann stability criterion may be satisfied at each point of the numerical model. To address this issue, I generalize von Neumann analysis for a model of two half-spaces. I perform the analysis for the case of acoustic wave propagation using a standard staggered-grid finite-difference numerical scheme. By deriving expressions for the discrete reflection and transmission coefficients, I study under what conditions the discrete reflection and transmission coefficients become unbounded. I find that instabilities encountered in numerical modeling near interfaces with strong material contrasts are linked to these cases and develop a modified stability criterion that takes into account the resulting instabilities. I test and verify the stability criterion by executing a finite-difference algorithm under conditions predicted to be stable and unstable. ?? 2007 Society of Exploration Geophysicists.

  19. Carl Neumann's Contributions to Electrodynamics

    NASA Astrophysics Data System (ADS)

    Schlote, Karl-Heinz

    2004-09-01

    I examine the publications of Carl Neumann (1832 1925) on electrodynamics, which constitute a major part of his work and which illuminate his approach to mathematical physics. I show how Neumann contributed to physics at an important stage in its development and how his work led to a polemic with Hermann Helmholtz (1821 1894). Neumann advanced and extended the ideas of the Königsberg school of mathematical physics. His investigations were aimed at founding a mathematically exact physical theory of electrodynamics, following the approach of Carl G.J. Jacobi (1804 1851) on the foundation of a physical theory as outlined in Jacobi’s lectures on analytical mechanics. Neumann’s work also shows how he clung to principles that impeded him in appreciating and developing new ideas such as those on field theory that were proposed by Michael Faraday (1791 1867) and James Clerk Maxwell (1831 1879).

  20. Acute generalized exanthematous pustulosis x Von Zumbusch’s pustular psoriasis: A diagnostic challenge in a psoriatic patient*

    PubMed Central

    de Sousa, Aline Soares; Lara, Osório Alves Corrêa de Castro; Papaiordanou, Francine; Marchioro, Gláucia Silva Simioni; Tebcherani, Antonio José

    2015-01-01

    Severe cutaneous drug reactions include a wide spectrum of clinical manifestations ranging from mild morbilliform cutaneous rash, to severe forms of hypersensitivity. Special attention is given in this report to the acute generalized exanthematous pustulosis (AGEP), induced in 90% of cases by the use of systemic drugs, especially aminopenicillins and macrolides. The incidence of the disease is low, 1-5 cases per million patients / year. The main differential diagnosis is Von Zumbusch's Pustular Psoriasis. The prognosis is generally good and the disease self limited, after withdrawal of the triggering drug. In this report the authors describe a case of AGEP, triggered by ceftriaxone in a patient with psoriasis vulgaris. PMID:26375226

  1. The nebular research of Carl Wirtz

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Seitter, W. C.

    We briefly review the nebular research in the 19th and early 20th century, and the role played by the newly founded Strasbourg Observatory in this field. The life of Carl Wirtz (1874-1939) is outlined. His studies in Bonn, his work in Vienna and Hamburg, his astronomical activity in Strasbourg from 1903-1916, at the war headquarters in Berlin in the following two years, and from 1919 up to his forced retirement in 1937 at Kiel University are described, both in general terms and specifically in terms of extragalactic research. His achievements were rarely recognized by his contemporaries, both because of his somewhat unusual way of presentation, and because of his "inner emigration" in the last years of his life.

  2. [A tribute to Carl Djerassi].

    PubMed

    Zárate, Arturo; Saucedo, Renata

    2015-01-01

    On January 15, 2015, Carl Djerassi, an extraordinary personality, died at the age of 91 years. He was born in Vienna, Austria, on October 29, 1923. His parents were physicians and probably he wanted to be also a physician, but sooner than later he chose to be a chemist. In 1939 he arrived to live to New York with his mother. In 1945 he became American citizen. Part of his work is the first commercial antihistamine, pyribenzamine, and the first successful combined oral contraceptive pill. With this editorial we make a tribute to this steroid pioneer.

  3. Martin Bartels als Lehrer von Carl Friedrich Gauß.

    NASA Astrophysics Data System (ADS)

    Dick, W. R.

    The role of the young Martin Bartels (1769 - 1836), later professor of mathematics at Kazan and Dorpat, as a teacher of C. F. Gauß is discussed on the basis of his autobiographic notes and of reminiscences by the astronomer Otto Struve, the son of Bartel's son-in-law Wilhelm Struve.

  4. Bragg-von Laue diffraction generalized to twisted X-rays.

    PubMed

    Jüstel, Dominik; Friesecke, Gero; James, Richard D

    2016-03-01

    A pervasive limitation of nearly all practical X-ray methods for the determination of the atomic scale structure of matter is the need to crystallize the molecule, compound or alloy in a sufficiently large (∼ 10 × 10 × 10 µm) periodic array. In this paper an X-ray method applicable to structure determination of some important noncrystalline structures is proposed. It is designed according to a strict mathematical analog of von Laue's method, but replacing the translation group by another symmetry group, and simultaneously replacing plane waves by different exact closed-form solutions of Maxwell's equations. Details are presented for helical structures like carbon nanotubes or filamentous viruses. In computer simulations the accuracy of the determination of structure is shown to be comparable to the periodic case. PMID:26919370

  5. Bragg-von Laue diffraction generalized to twisted X-rays.

    PubMed

    Jüstel, Dominik; Friesecke, Gero; James, Richard D

    2016-03-01

    A pervasive limitation of nearly all practical X-ray methods for the determination of the atomic scale structure of matter is the need to crystallize the molecule, compound or alloy in a sufficiently large (∼ 10 × 10 × 10 µm) periodic array. In this paper an X-ray method applicable to structure determination of some important noncrystalline structures is proposed. It is designed according to a strict mathematical analog of von Laue's method, but replacing the translation group by another symmetry group, and simultaneously replacing plane waves by different exact closed-form solutions of Maxwell's equations. Details are presented for helical structures like carbon nanotubes or filamentous viruses. In computer simulations the accuracy of the determination of structure is shown to be comparable to the periodic case.

  6. Habitat Evaluation Procedures Report; Carl Property - Yakama Nation.

    SciTech Connect

    Ashley, Paul; Muse, Anthony

    2008-02-01

    A baseline habitat evaluation procedures (HEP) analysis was conducted on the Carl property (160 acres) in June 2007 to determine the number of habitat units to credit Bonneville Power Administration (BPA) for providing funds to acquire the property as partial mitigation for habitat losses associated with construction of McNary Dam. HEP surveys also helped assess the general ecological condition of the property. The Carl property appeared damaged from livestock grazing and exhibited a high percentage of invasive forbs. Exotic grasses, while present, did not comprise a large percentage of the available cover in most areas. Cover types were primarily grassland/shrubsteppe with a limited emergent vegetation component. Baseline HEP surveys generated 356.11 HUs or 2.2 HUs per acre. Habitat units were associated with the following HEP models: California quail (47.69 HUs), western meadowlark (114.78 HUs), mallard (131.93 HUs), Canada goose (60.34 HUs), and mink (1.38 HUs).

  7. [Carl Gustav Jung's alchemical thinking].

    PubMed

    Mirkiewicz, Jakub

    2004-01-01

    Carl Gustav Jung (1875-1961), Swiss psychologist and philosopher of culture used in his concepts many constructs having their source in philosophy of alchemy. These ideas can be found not only in his books on alchemy but also in his psychological works. Among them we should enumerate: the theory of psychological process, the concepts of opposites coexisting in the psyche, the polar structure of notions in his psychological system and the idea of synchronicity. The author of this article examines these main points of Jungian program within the context of its parallelism with paracelsian alchemical philosophy of nature: the process of nature, alchemical dialectics and the universal analogy of micro- and macrocosmos. At the beginning of his work, creating his psychology Jung assumed similar ideas. Later, when he noticed this similarity, alchemy became very helpful in his research of psyche, because thanks to them he conceptualised the successive aspects of polar structure of dynamical psychical reality, which--like his alchemical predecessors--he used to explain basics of the micro- and macro-world. PMID:17152876

  8. [Carl Gustav Jung's alchemical thinking].

    PubMed

    Mirkiewicz, Jakub

    2004-01-01

    Carl Gustav Jung (1875-1961), Swiss psychologist and philosopher of culture used in his concepts many constructs having their source in philosophy of alchemy. These ideas can be found not only in his books on alchemy but also in his psychological works. Among them we should enumerate: the theory of psychological process, the concepts of opposites coexisting in the psyche, the polar structure of notions in his psychological system and the idea of synchronicity. The author of this article examines these main points of Jungian program within the context of its parallelism with paracelsian alchemical philosophy of nature: the process of nature, alchemical dialectics and the universal analogy of micro- and macrocosmos. At the beginning of his work, creating his psychology Jung assumed similar ideas. Later, when he noticed this similarity, alchemy became very helpful in his research of psyche, because thanks to them he conceptualised the successive aspects of polar structure of dynamical psychical reality, which--like his alchemical predecessors--he used to explain basics of the micro- and macro-world.

  9. Gnostic inner illumination and Carl Jung's individuation.

    PubMed

    Pennachio, J

    1992-09-01

    The ancient religious system of Gnosticism argued for the transcendence of the physical world and the divinity of self-knowledge. More recently, a similar argument was made by Carl Jung through his concept of individuation. This paper examines some of the similarities between Gnostic inner illumination and Jung's concept of individuation.

  10. Carl Rogers and Me: Revisiting Teaching.

    ERIC Educational Resources Information Center

    Li, Li-Te

    2003-01-01

    Discusses connections between Carl Rogers and literacy by introducing Rogers' major contributions and by discussing the implementation of his ideas in an English as a Foreign Language (EFL) classroom in Taiwan. Explains Rogers' ideas about teachers as facilitators; learner-centered learning; and building freedom. Concludes that person-centered…

  11. Carl Rogers' Alternative to Traditional Rhetoric.

    ERIC Educational Resources Information Center

    Hairston, Maxine C.

    Carl Rogers' approach to communication has implications for the rhetorician and the teacher of college composition. The qualities of respect, restraint, neutrality, and understanding, when applied to written and oral discourse, can provide an effective alternative to polemical argumentation. The detatchment and empathy of the Rogerian style is…

  12. What Are They Doing to Carl Rogers?

    ERIC Educational Resources Information Center

    Mader, Diane C.

    1980-01-01

    Notes that recent composition textbooks have classified Carl Rogers' work as a new rhetoric or as an alternative to classical argument. Demonstrates that to portray Rogers' method as a form of argument is to misunderstand his intent and that, while Rogers and Aristotle are similar superficially, their differences are profound. (FL)

  13. Denigrating Carl Rogers: William Coulson's Last Crusade.

    ERIC Educational Resources Information Center

    Kirschenbaum, Howard

    1991-01-01

    Reviews William Coulson's assertions that Carl Rogers, Abraham Maslow, and he initiated the humanistic education field, that Rogers repudiated his philosophy late in life, and that they owe the nation's parents an apology. Argues that these charges are groundless and provides examples and quotations from Rogers' later writings to show how Rogers…

  14. Eric Carle-Inspired Insect Collages.

    ERIC Educational Resources Information Center

    Palamountain, Eileen; Turner, Kim

    2000-01-01

    Describes a lesson in which students create collage insects inspired by the work of Eric Carle (The Very Hungry Caterpillar). Connects art, language arts, and science. Discusses how students make paper to use as the collage material and how students create the insects. (CMK)

  15. Secondary structure adventures with Carl Woese

    PubMed Central

    Noller, Harry F

    2014-01-01

    Not long after my arrival at UCSC as an assistant professor, I came across Carl Woese's paper “Molecular Mechanics of Translation: A Reciprocating Ratchet Mechanism.”1 In the days before the crystal structure of tRNA was known, Fuller and Hodgson2 had proposed two alternative conformations for its anticodon loop; one was stacked on the 3′ side (as later found in the crystal structure) and the other on the 5′ side. In an ingenious and elegant model, Woese proposed that the conformation of the loop flips between Fuller and Hodgson's 5′- and 3′-stacked forms during protein synthesis, changing the local direction of the mRNA such that the identities of the tRNA binding sites alternated between binding aminoacyl-tRNA and peptidyl-tRNA. The model predicted that there are no A and P sites, only two binding sites whose identities changed following translation of each codon, and that there would be no translocation of tRNAs in the usual sense—only binding and release. I met Carl in person the following year when he presented a seminar on his ratchet model in Santa Cruz. He was chatting in my colleague Ralph Hinegardner's office in what Carl termed a “Little Jack Horner appointment” (the visitor sits and listens to his host describing “What a good boy am I”). He was of compact stature, and bore a striking resemblance to Oskar Werner in Truffaut's film “Jules and Jim.” He projected the impression of a New-Age guru—a shiny black amulet suspended over the front of his black turtleneck sweater and a crown of prematurely white hair. Ralph asked me to explain to Carl what we were doing with ribosomes. I quickly summarized our early experiments that were pointing to a functional role for 16S rRNA. Carl regarded me silently, with a penetrating stare. He then turned to Ralph and said, in an ominous low voice, “I'm going to have some more tanks made as soon as I get back.” Carl's beautiful model was, unfortunately, wrong—it was simpler and more

  16. B.F. Skinner and Carl R. Rogers on Behavior and Education.

    ERIC Educational Resources Information Center

    Swaim, Eugene E.

    1972-01-01

    The purpose of this study is to analyze the relationship between the theories of B.F. Skinner and Carl R. Rogers. In sections 2 and 3, the author discusses the Skinnerian and Rogerian theories by selecting and explicating key elements and delineating the general, comprehensive, theoretical position of each. Sections 4 and 5 present each man's…

  17. [Eugen Bleuler and Carl Gustav Jung's habilitation].

    PubMed

    Wilhelm, H R

    1996-01-01

    Eugen Bleuler's letter of recommendation for Carl Gustav Jung's appointment as a lecturer In January 1905, Eugen Bleuler (1857-1939) wrote a letter of recommendation to the Medical Faculty of the University of Zurich, urging them to accept the application of Carl Gustav Jung (1875-1961) as a lecturer there. Bleuler's letter mentions the contribution to Jung's writing made by Franz Riklin (1878-1938), although he does not define it precisely. It is safe to say that, judging from the way in which Bleuler expresses his opinions in this letter, this may be regarded at the very least as an early sign of his receptiveness to the psychoanalytical ideas of the time. PMID:8928214

  18. [Eugen Bleuler and Carl Gustav Jung's habilitation].

    PubMed

    Wilhelm, H R

    1996-01-01

    Eugen Bleuler's letter of recommendation for Carl Gustav Jung's appointment as a lecturer In January 1905, Eugen Bleuler (1857-1939) wrote a letter of recommendation to the Medical Faculty of the University of Zurich, urging them to accept the application of Carl Gustav Jung (1875-1961) as a lecturer there. Bleuler's letter mentions the contribution to Jung's writing made by Franz Riklin (1878-1938), although he does not define it precisely. It is safe to say that, judging from the way in which Bleuler expresses his opinions in this letter, this may be regarded at the very least as an early sign of his receptiveness to the psychoanalytical ideas of the time.

  19. Malcolm Knowles and Carl Rogers.

    ERIC Educational Resources Information Center

    Boyer, Dennis L.

    1984-01-01

    The aim of this paper is to examine primary concerns related to the introduction of Knowles's and Rogers's theories of adult education. Comparison of andragogy and student-centered theories includes the following areas: overview, foundations, general goals, learning principles, and teaching and learning and is followed by a summary and…

  20. [Complementarity and Gestalt circle--Viktor von Weizsäcker and the importance of a general theory of illness].

    PubMed

    Küppers, B

    1992-05-01

    Two developments have led to the elaboration of a complementarity theory in modern natural science--the Copenhagen interpretation of quantum mechanics and Viktor von Weizsäckers introduction of the subject into biology. The revolutionary implications of these developments are discernible in modern literature. The author seeks to show that a paradigm shift in positivistic clinical medicine is necessitated by the history and theory of science.

  1. 2. Historic American Buildings Survey, Carl Waite, Photographer June 29, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Carl Waite, Photographer June 29, 1936 MAIN DOORWAY (WEST ELEVATION). - Joshua R. Giddings Law Office, Chestnut & Walnut Streets, Jefferson, Ashtabula County, OH

  2. 4. Historic American Buildings Survey, Carl Waite, Photographer June 29, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Carl Waite, Photographer June 29, 1936 INTERIOR DETAIL (NORTH ELEVATION). - Joshua R. Giddings Law Office, Chestnut & Walnut Streets, Jefferson, Ashtabula County, OH

  3. 3. Historic American Buildings Survey, Carl Waite, Photographer June 29, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Carl Waite, Photographer June 29, 1936 INTERIOR OF OFFICE (NORTH ELEVATION). - Joshua R. Giddings Law Office, Chestnut & Walnut Streets, Jefferson, Ashtabula County, OH

  4. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Marshall Space Flight Center director Wernher Von Braun and his family were honored with a series of events prior to his relocation to Washington, D.C. where he was assigned duties at NASA headquarters as deputy associate administrator for planning. Here he is shown with General Richard Drury and Hazel Toftoy, widow of General H.N. Toftoy.

  5. Frederick Carl Frieseke: The Evolution of an American Impressionist.

    ERIC Educational Resources Information Center

    Johnson, Mark M.

    2002-01-01

    Provides background information on the life and career of Frederick Carl Frieseke, an artist who painted in the style of impressionism. Explains that this artist is the focus of a retrospective exhibition entitled, "Frederick Carl Frieseke: The Evolution of an American Impressionist" at the Telfair Museum of Art (Savannah, Georgia). (CMK)

  6. 7. Historic American Buildings Survey Carl Magro, Photographer May 1936, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey Carl Magro, Photographer May 1936, Copied by Joseph Hill. VALVE CONTROL LEVERS ON WEST GATE - Illinois & Michigan Canal, Locks & Lockhouse, Channahon, Will County, IL

  7. 1. Historic American Buildings Survey, Carl Waite, Photographer June 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Carl Waite, Photographer June 10, 1936 SOUTH ELEVATION (COPY MADE FROM OLD PHOTO). - St. Christopher's-By-The-River, Old Mill Road, Gates Mills, Cuyahoga County, OH

  8. 3. Historic American Buildings Survey, Carl Waite, Photographer June 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Carl Waite, Photographer June 10, 1936 DETAIL OF MAIN ENTRANCE (SOUTH ELEVATION). - St. Christopher's-By-The-River, Old Mill Road, Gates Mills, Cuyahoga County, OH

  9. 1. Historic American Buildings Survey, Carl Waite, Photographer June 10, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Carl Waite, Photographer June 10, 1936 MAIN ENTRANCE DETAIL (NORTH ELEVATION. - Chagrin Valley Hunt Club (Doorway), Mayfield & River Roads, Gates Mills, Cuyahoga County, OH

  10. The Face We Put On: Carl Jung for Teachers.

    ERIC Educational Resources Information Center

    Craig, Robert P.

    1994-01-01

    Examines Carl Jung's concept of the "persona" (his term for the masks people wear). Notes how teachers use personae and suggests ways to restore the energy that teachers lose when hiding inside their personae. (SR)

  11. Encountering Carl Rogers: His Views on Facilitating Groups.

    ERIC Educational Resources Information Center

    Landreth, Garry L.

    1984-01-01

    Presents Carl Rogers' views on facilitating groups, as expressed in a telephone dialogue seminar with graduate students in counselor education at North Texas State University. Discusses extended group marathons, cocounseling, nonverbal group exercises and the future of group work. (JAC)

  12. 1. Historic American Buildings Survey, Carl Waite, Photographer September 29, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Carl Waite, Photographer September 29, 1936 SOUTH ELEVATION (TAKEN FROM OLD PHOTOGRAPH). - H. M. Gillette Residence, Route 18, Blue Goose Corners, Wellington, Lorain County, OH

  13. Dr. Wernher Von Braun with Dr. Christian Barnard.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Christian Barnard Tours Marshall Space Flight Center. Shown in Dr. Von Braun's office are (left to right): Dr. Ernst Sthulinger, a representative from General Electric, Dr. Wernher Von Braun, Dr. Christian Barnard, and Dr. Eberhard Rees.

  14. Carl Linnaeus and the visual representation of nature.

    PubMed

    Charmantier, Isabelle

    2011-01-01

    The Swedish naturalist Carl Linnaeus (1707-1778) is reputed to have transformed botanical practice by shunning the process of illustrating plants and relying on the primacy of literary descriptions of plant specimens. Botanists and historians have long debated Linnaeus's capacities as a draftsman. While some of his detailed sketches of plants and insects reveal a sure hand, his more general drawings of landscapes and people seem ill-executed. The overwhelming consensus, based mostly on his Lapland diary (1732), is that Linnaeus could not draw. Little has been said, however, on the role of drawing and other visual representations in Linnaeus's daily work as seen in his other numerous manuscripts. These manuscripts, held mostly at the Linnean Society of London, are peppered with sketches, maps, tables, and diagrams. Reassessing these manuscripts, along with the printed works that also contain illustrations of plant species, shows that Linnaeus's thinking was profoundly visual and that he routinely used visual representational devices in his various publications. This paper aims to explore the full range of visual representations Linnaeus used through his working life, and to reevaluate the epistemological value of visualization in the making of natural knowledge. By analyzing Linnaeus's use of drawings, maps, tables, and diagrams, I will show that he did not, as has been asserted, reduce the discipline of botany to text, and that his visual thinking played a fundamental role in his construction of new systems of classification. PMID:22363966

  15. On the history of Ludwig von Bertalanffy's "General Systemology", and on its relationship to cybernetics - part III: convergences and divergences

    NASA Astrophysics Data System (ADS)

    Drack, Manfred; Pouvreau, David

    2015-07-01

    Bertalanffy's so-called "general system theory" (GST) and cybernetics were and are often confused: this calls for clarification. In this article, Bertalanffy's conceptions and ideas are compared with those developed in cybernetics in order to investigate the differences and convergences. Bertalanffy was concerned with first order cybernetics. Nonetheless, his perspectivist epistemology is also relevant with regard to developments in second order cybernetics, and the latter is therefore also considered to some extent. W. Ross Ashby's important role as mediator between GST and cybernetics is analysed. The respective basic epistemological approaches, scientific approaches and inherent world views are discussed. We underline the complementarity of cybernetic and "organismic" trends in systems research within the unitary hermeneutical framework of "general systemology".

  16. The Uniqueness of Similarities: Parallels of Milton H. Erickson and Carl Rogers.

    ERIC Educational Resources Information Center

    Gunnison, Hugh

    1985-01-01

    Describes the influence of the philosophy and values of Carl Rogers and Milton Erickson on the counseling profession. Reviews the person-centered approach, direction, therapeutic climate, and the influence of early experiences. Includes a reaction by Carl Rogers. (JAC)

  17. Carl Sagan and the Exploration of Mars and Venus

    NASA Technical Reports Server (NTRS)

    Toon, Owen B.; Condon, Estelle P. (Technical Monitor)

    1997-01-01

    Inspired by childhood readings of books by Edgar Rice Burroughs, Carl Sagan's first interest in planetary science focused on Mars and Venus. Typical of much of his career he was skeptical of early views about these planets. Early in this century it was thought that the Martian wave of darkening, a seasonal albedo change on the planet, was biological in origin. He suggested instead that it was due to massive dust storms, as was later shown to be the case. He was the first to recognize that Mars has huge topography gradients across its surface. During the spacecraft era, as ancient river valleys were found on the planet, he directed studies of Mars' ancient climate. He suggested that changes in the planets orbit were involved in climate shifts on Mars, just as they are on Earth. Carl had an early interest in Venus. Contradictory observations led to a controversy about the surface temperature, and Carl was one of the first to recognize that Venus has a massive greenhouse effect at work warming its surface. His work on radiative transfer led to an algorithm that was extensively used by modelers of the Earth's climate and whose derivatives still dominate the calculation of radiative transfer in planetary atmospheres today. Carl inspired a vast number of young scientists through his enthusiasm for new ideas and discoveries, his skeptical approach, and his boundless energy. I had the privilege to work in Carl's laboratory during the peak of the era of Mars' initial exploration. It was an exciting time, and place. Carl made it a wonderful experience.

  18. Organelle evolution, fragmented rRNAs, and Carl

    PubMed Central

    Gray, Michael W

    2014-01-01

    I am honored to have been asked to contribute to this memorial issue, although I cannot claim to have known Carl Woese well. Carl’s insights and the discoveries that his research group made over the years certainly stimulated my own research program, and at several points early on, interactions with him were pivotal in my career. Here I comment on these personal dealings with Carl and emphasize his influence in two areas of long-standing interest in my lab: organelle evolution and rRNA evolution. PMID:24572720

  19. Carl Rogers during Initial Interviews: A Moderate and Consistent Therapist.

    ERIC Educational Resources Information Center

    Edwards, H. P.; And Others

    1982-01-01

    Analyzed two initial interviews by Carl Rogers in their entirety using the Carkhuff scales, Hill's category system, and a brief grammatical analysis to establish the level and consistency with which Rogers provides facilitative conditions. Results indicated his behavior as counselor was stable and consistent within and across interviews. (Author)

  20. Carl R. Rogers (1902-1987): Friend, Gentleman, and Scholar.

    ERIC Educational Resources Information Center

    Van Hesteren, Frank

    1988-01-01

    Writes in memory of Carl R. Rogers. Conveys a sense of the spirit of Rogers' thinking and the kind of person he was, both in his own eyes and in the experience of those who knew him personally. Concludes with a discussion of how Rogers'"way of being" has influenced the writer's own personal and professional development. (Author/KS)

  1. Carl Sagan: Cosmic Evolution vs. the Creationist Myth.

    ERIC Educational Resources Information Center

    Harnack, William J.

    1981-01-01

    Considers the dichotomy between the cosmic perspective and the creationist view. Presents an overview of various current explanations of the origin and nature of the universe, including scientific explanations, fundamentalist beliefs, and creation myths from other cultures. The article is based on comments made by Carl Sagan at the American…

  2. Carl Upchurch: Journey from Prisoner Citizen to Educator

    ERIC Educational Resources Information Center

    Kronick, Robert; Thomas, Denis

    2009-01-01

    Carl Upchurch was born and raised in Philadelphia in the 1950's. His mother, uncle and grandmother socialized him during his early childhood. His grandmother was his primary caregiver and a prostitute, his father drifted in and out of his life, and his uncle died in a gunfight. All this shaped Upchurch as a person and led to his development of the…

  3. Synthesizing a Life: An Interview with Carl Djerassi

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2011-01-01

    In this interview, Carl Djerassi recalls his first years, from his pleasant childhood, to how he escaped the Nazi persecutions, to his college education in America. He remembers how with his research group he won the race for synthesis of cortisone, and how they then synthesized norethindrone, the active ingredient in oral contraceptives. Djerassi…

  4. 14. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) FIRST FLOOR, DAY ROOM OF TYPICAL COTTAGE - Ohio Soldiers' & Sailors' Home, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  5. 17. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) FIRST FLOOR, READING ROOM, LOOKING WEST - Ohio Soldiers' & Sailors' Home, Library, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  6. 11. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) VIEW SOUTHEAST, NORTHWEST FRONT - Ohio Soldiers' & Sailors' Home, Cottage H, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  7. 12. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) VIEW SOUTHEAST, NORTHWEST FRONT - Ohio Soldiers' & Sailors' Home, Cottage M, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  8. 16. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) VIEW SOUTHWEST, NORTHEAST FRONT - Ohio Soldiers' & Sailors' Home, Library, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  9. 10. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n. d.) PANORAMA VIEW LOOKING SOUTHEAST - Ohio Soldiers' & Sailors' Home, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  10. 19. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) SECOND FLOOR, GRAND ARMY HALL, LOOKING EAST - Ohio Soldiers' & Sailors' Home, Library, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  11. 14. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) VIEW EAST, NORTHWEST SIDE SHOWING ORIGINAL PORCH, CUPOLA, & WINDOWS - Ohio Soldiers' & Sailors' Home, Cottage L, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  12. 16. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) LOCATION UNKNOWN - Ohio Soldiers' & Sailors' Home, Boilerhouse, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  13. The legacy of Carl Vincent Gisolfi in temperature regulation

    PubMed Central

    Tipton, Charles M; Kregel, Kevin C

    2014-01-01

    Carl Vincent Gisolfi (1942–2008) was a Distinguished Professor of Exercise Science at the University of Iowa whose contributions included mentoring future investigators and seminal studies in the areas of thermoregulation during exercise, responses of the diencephalon to elevated temperatures, fluid absorption during heat stress, and the role of heat shock proteins in circulatory failure.

  14. Public Information for All: An Interview with Carl Malamud

    ERIC Educational Resources Information Center

    Rabina, Debbie

    2010-01-01

    Since the early 1990s, Carl Malamud has made it his business to return to the public what is rightfully theirs: free access to public information. Despite legislation that mandates such access to government information, some categories of information have been excluded, notable among them court opinions (with the exception of the U.S. Supreme…

  15. Carl Ludwig: the man, his time, his influence.

    PubMed

    Zimmer, H G

    1996-01-01

    Carl Ludwig (1816-1895) was the driving force in the foundation and development of scientifically based and experimentally oriented physiology against natural philosophy and vitalism that prevailed during the first quarter of the 19th century in Germany. He was the representative of a small group of young, highly talented and dynamic physiologists aiming at implementing the laws of physics and chemistry as the only active forces in physiologic processes. These "organic physicists" included Emil du Bois-Reymond (1818-1896), Ernst Brücke (1819-1892), and Hermann Helmholz (1821-1894). Carl Ludwig wrote the program of this group in the form of a textbook of physiology that was considered revolutionary, provocative and premature. His academic life, his inventions and discoveries, his scientific achievements, his influence and his personality are reviewed. Since every person can be viewed only in the context of his time, the political background, the economic and social situation, the conditions for science and research as well as the cultural climate that were characteristic for the decisive years of Carl Ludwig are described to some extent. It is shown that Carl Ludwig and his contemporary organic physicists lived and grew into a science- and research-oriented period which had been prepared and paved by men like Johannes Evangelista Purkinje (1787-1869), Ernst Heinrich Weber (1795-1878), Alfred Wilhelm Volkmann (1800-1877), Johannes Müller (1801-1858) and Gustav Theodor Fechner (1801-1887). They benefited from this enormous scientific development and contributed to it to a large and significant extent so that it ultimately turned out to be the most productive and influential period in the history of German physiology. Some of the numerous scholars who had studied with Carl Ludwig carried his approach to physiology into the 20th century: Adolf Fick (1829-1901), Otto Frank (1865-1944), Iwan Petrowitsch Pawlow (1849-1936) and Henry Pickering Browditch (1840-1911).

  16. Carl Ludwig: the man, his time, his influence.

    PubMed

    Zimmer, H G

    1996-01-01

    Carl Ludwig (1816-1895) was the driving force in the foundation and development of scientifically based and experimentally oriented physiology against natural philosophy and vitalism that prevailed during the first quarter of the 19th century in Germany. He was the representative of a small group of young, highly talented and dynamic physiologists aiming at implementing the laws of physics and chemistry as the only active forces in physiologic processes. These "organic physicists" included Emil du Bois-Reymond (1818-1896), Ernst Brücke (1819-1892), and Hermann Helmholz (1821-1894). Carl Ludwig wrote the program of this group in the form of a textbook of physiology that was considered revolutionary, provocative and premature. His academic life, his inventions and discoveries, his scientific achievements, his influence and his personality are reviewed. Since every person can be viewed only in the context of his time, the political background, the economic and social situation, the conditions for science and research as well as the cultural climate that were characteristic for the decisive years of Carl Ludwig are described to some extent. It is shown that Carl Ludwig and his contemporary organic physicists lived and grew into a science- and research-oriented period which had been prepared and paved by men like Johannes Evangelista Purkinje (1787-1869), Ernst Heinrich Weber (1795-1878), Alfred Wilhelm Volkmann (1800-1877), Johannes Müller (1801-1858) and Gustav Theodor Fechner (1801-1887). They benefited from this enormous scientific development and contributed to it to a large and significant extent so that it ultimately turned out to be the most productive and influential period in the history of German physiology. Some of the numerous scholars who had studied with Carl Ludwig carried his approach to physiology into the 20th century: Adolf Fick (1829-1901), Otto Frank (1865-1944), Iwan Petrowitsch Pawlow (1849-1936) and Henry Pickering Browditch (1840-1911). PMID

  17. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher von Braun with Dr. Eberhard Rees and R.W. Cook at a press conference concerning Dr. Von Braun's assignment to NASA headquarters and Dr. Rees' subsequent assignment as Marshall Center director.

  18. Re-Discovering Mendel: The Case of Carl Correns

    ERIC Educational Resources Information Center

    Rheinberger, Hans-Jörg

    2015-01-01

    Carl Erich Correns (1864-1933) is remembered in the annals of science as one of the three botanists who re-discovered Mendel's laws. He can also, however, be regarded as one of the founding figures of classical genetics in Germany. Between 1894 and 1899 he carried out the crossing experiments with corn and peas that led to the re-statement of…

  19. Dr. Wernher Von Braun presents a certificate

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left), director of the Marshall Space Flight Center, presents a humorous certificate to Major General Charles W. Eifler, commanding general of Redstone Arsenal, at the close of a farewell luncheon for the general prior to General Eifler moving to a new European duty station.

  20. Theodore von Karman

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. Theodore von Karman, co-founder of the Jet Propulsion Laboratory (JPL) Pasadena, California was an aeronautical theoretician. His contributions in the fields of aerodynamics and aeronautical engineering are well documented and well known to every aerospace engineer. He was the first winner of the prestigious U.S. Medal of Science presented to him by President John F. Kennedy. As well as being co-founder of JPL, he also was principal founder of a major rocket propulsion firm (Aerojet-General Corp.), the top science advisor to the U.S. Air Force during its transition to jet propulsion aircraft and the top science advisor to NATO. He was, during much of this time, the fountainhead of aerodynamic thought as head of the Guggenheim Aeronautical Laboratory at the California Institute of Technology (GALCIT) in Pasadena, California. In the May 1956 issue of the Journal of Aeronautical Sciences, it was said of him that 'No other man has had so great an impact on the development of aeronautical science in this country. Hundreds of young men became his students and scientific collaborators and were inspired to greater effort.' Dr. William H. Pickering, then director of JPL said in 1960 'We wouldn't have an aeronautical science as we know it today, if it weren't for Dr. Thoedore von Karman.' Under his guidance, Caltech's 10 foot wind tunnel was designed, built and operated. Industry firms such as Douglas, Northrop, Hughes, Lockheed, North American, Vultee and Consolidated all tested new aeronautical designs and concepts in GALCIT's tunnel. Even Boeing's own high-speed wind tunnel was heavily influenced by suggestions from von Karman. The National Advisory Committee for Aeronautics (NACA) became so concerned about GALCIT's growing influence over West coast aviation, it erected the Ames Laboratory in Sunnyvale, California in part to deter an ever widening aeronautical gap that had formed between NACA and GALCIT. From 1936 to 1940, Caltech stood alone as the only university

  1. Conversations: with Carl Pilcher [interview by Johan Benson].

    PubMed

    Pilcher, C

    1998-11-01

    An interview with Carl Pilcher, science program director for solar system exploration at NASA, examines NASA's past, present, and planned missions to explore the solar system. Specific questions relate to the status of current and planned missions, science results of the Pathfinder mission to Mars, cooperation with the Japanese space agency, the status of the search for extraterrestrial life in solar system meteoroids and asteroids, mission size for more in-depth exploration, reports of water on the moon, and the exploration of near-Earth objects.

  2. The anthropology of Carl Jung: Implications for pastoral care.

    PubMed

    Hunt-Meeks, S

    1983-09-01

    This article examines the basic tenets of Carl Jung's anthropology, including intrapsychic structure, relationships, society, and the process of individuation. It then turns to his ideas about God and religion. Jung builds his understanding of God from his work in psychology, and because of that method, there are several major problems with his theologizing. Nevertheless, his insights are extremely valuable to the field of pastoral care, and ministers would do very well to appreciate his contribution, though always with a critical eye to its limitation.

  3. The professionalization of Carl G. Jung's analytical psychology clubs.

    PubMed

    Samuels, A

    1994-04-01

    This paper addresses (1) the history of a cluster of unusual institutions-analytical psychology clubs--which started in 1916 and by 1934 had become established in many of the countries in the world in which there was interest in the analytical psychology of Carl G. Jung; (2) the conflicts involved in trying to unite the relatively informal earlier "Jung Clubs" with the more formal societies being established by the increasing numbers of professionally trained analysts; and (3) the wider cultural and social issues included in the professionalization of analytical psychology.

  4. Conversations: with Carl Pilcher [interview by Johan Benson].

    PubMed

    Pilcher, C

    1998-11-01

    An interview with Carl Pilcher, science program director for solar system exploration at NASA, examines NASA's past, present, and planned missions to explore the solar system. Specific questions relate to the status of current and planned missions, science results of the Pathfinder mission to Mars, cooperation with the Japanese space agency, the status of the search for extraterrestrial life in solar system meteoroids and asteroids, mission size for more in-depth exploration, reports of water on the moon, and the exploration of near-Earth objects. PMID:11541412

  5. Tutorial Facilitation in the Humanities Based on the Tenets of Carl Rogers

    ERIC Educational Resources Information Center

    Heim, Caroline

    2012-01-01

    This article introduces a model for group facilitation in the humanities based on Carl Rogers' model for group psychotherapy. Certain aspects of Carl Rogers' reflective learning strategies are reappraised and principles, specific only to psychotherapy, are introduced. Five of Rogers' axioms are applied to the tutorial discussion model: a…

  6. Science fiction and the history of the astro-department of Carl Zeiss Jena (German Title: Science Fiction und die Geschichte der Astroabteilung von Carl Zeiss Jena)

    NASA Astrophysics Data System (ADS)

    Beck, Hans G.

    This contribution uses the literary form of science fiction in retrospect, in order to display the initial conditions given in the run-up of the founding of the astro-department of the Zeiss factory. Written minutes (supposedly found during restoration works in the people's house in Jena) introduce the participants of a sort of founding party of the main actors Ernst Abbe, Otto Schott, Siegfried Czapski, Hans Harting, Albert König, Franz Meyer and Walter Villiger. Their contributions to the discussion yield a market analysis, based on the past development of the technology of astronomical instruments, the international competitors' state of the art, and the assessment of the future development in astronomy and especially of astrophysics. The contribution presents a piece of modern history of the year 1987; it was presented as a talk on May 13 of the same year, when Rolf Riekher celebrated his 65th birthday.

  7. Wernher von Braun with German Officers and Others

    NASA Technical Reports Server (NTRS)

    1942-01-01

    General Erich Fellgiebel, head of the German Army Information Service during World War II, congratulates members of the von Braun rocket team from Peenemunde for their October 3, 1942 A4 flight. Pictured front center is General Erich Fellgiebel. Shaking hands are General Walter Dornberger (left) and General Janssen, commanding officer of Peenemuende with Rudolph Hermarn to their right. Picture left to right in the back row are Wernher von Braun, Captain Stoelzel, Luftwaffe, and Dr. Gerhard Reisig.

  8. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left) and Fred W. Kelley examine a ST-100 Stellar Instrument Platform in the astrionics lab. Dr. Von Braun, then deputy associate administrator for planning, NASA, was visiting on the anniversary of the establishment of the Marshall Space Flight Center.

  9. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher Von Braun, stands in front of a Saturn IB Launch Vehicle at Kennedy Space Center (KSC). Dr. Von Braun was Marshall's first Center Director (1960-1970). Under his leadership Marshall was responsible for the development of the Saturn rockets, the Skylab project and getting the United States into Space and landing on the moon with the Apollo missions.

  10. Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

  11. Modeling time-varying growth using a generalized von Bertalanffy model with application to bloater (Coregonus hoyi) growth dynamics in Lake Michigan

    USGS Publications Warehouse

    Szalai, Emily B.; Fleischer, Guy W.; Bence, James R.

    2003-01-01

    A concurrent increase in lakewide abundance and decrease in size-at-age of bloater (Coregonus hoyi) in Lake Michigan have suggested density-dependent growth regulation. We investigated these temporal patterns by fitting a dynamic von Bertalanffy model and length–weight relationship with time-varying parameters to mean length- and weight-at-ages (ages 1–7) from annual surveys (1965-–1999). We modeled yearling length, asymptotic size (L‰), and the parameters of a power relationship between mean weight and mean length (α and β) as changing slowly over time using a random walk model. The Brody growth coefficient (k) was modeled as a linear function of L‰ with year-specific random deviations. Our results support a positive relationship between L‰ and k, indicating that under conditions supporting larger asymptotic lengths, individuals approach the asymptote more rapidly. We explored the relationship between year-specific growth parameters and indices of lakewide bloater abundance and found evidence of density-dependent growth. However, in the most recent years, L‰ and yearling length have remained low in Lake Michigan despite low bloater abundances, suggesting the occurrence of a fundamental shift in the food web.

  12. Group Theoretical Interpretation of von Neumann's Theorem on Composite Systems.

    ERIC Educational Resources Information Center

    Bergia, S.; And Others

    1979-01-01

    Shows that von Neumann's mathematical theorem on composite systems acquires a transparent physical meaning with reference to a suitable physical example; a composite system in a state of definite angular momentum. Gives an outline of the theorem, and the results are restated in Dirac's notation, thus generalizing von Neumann's results which were…

  13. Carl Rogers and the larger context of therapeutic thought.

    PubMed

    Wachtel, Paul L

    2007-09-01

    Carl Rogers' classic account (see record 2007-14639-002) of the necessary and sufficient conditions for therapeutic personality change is examined in light of developments in theory and practice since the time he wrote. Rogers' ideas, which diverged from and were very largely a challenge to, the dominant psychoanalytic ideology of the era in which he wrote, are considered in relation to new theoretical developments in what has come to be called relational psychoanalysis. They are also considered in light of the greatly increased influence of and substantial evidence supporting behavioral and cognitive-behavioral approaches. Points of convergence and divergence among these approaches are examined. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  14. Carl Gustav Jung and Granville Stanley Hall on Religious Experience.

    PubMed

    Kim, Chae Young

    2016-08-01

    Granville Stanley Hall (1844-1924) with William James (1842-1910) is the key founder of psychology of religion movement and the first American experimental or genetic psychologist, and Carl Gustav Jung (1875-1961) is the founder of the analytical psychology concerned sympathetically about the religious dimension rooted in the human subject. Their fundamental works are mutually connected. Among other things, both Hall and Jung were deeply interested in how the study of religious experience is indispensable for the depth understanding of human subject. Nevertheless, except for the slight indication, this common interest between them has not yet been examined in academic research paper. So this paper aims to articulate preliminary evidence of affinities focusing on the locus and its function of the inner deep psychic dimension as the religious in the work of Hall and Jung. PMID:27094706

  15. Re-discovering Mendel: The Case of Carl Correns

    NASA Astrophysics Data System (ADS)

    Rheinberger, Hans-Jörg

    2015-01-01

    Carl Erich Correns (1864-1933) is remembered in the annals of science as one of the three botanists who re-discovered Mendel's laws. He can also, however, be regarded as one of the founding figures of classical genetics in Germany. Between 1894 and 1899 he carried out the crossing experiments with corn and peas that led to the re-statement of Gregor Mendel's (1822-1884) results. Between 1900 and 1910, he explored the complications of these laws, including the coupling of factors due to their chromosomal location and the inheritance of sex, in a great number of plant species. In later years Correns became interested in and experimented on phenomena of extra-nuclear inheritance.

  16. Carl Gustav Jung and Granville Stanley Hall on Religious Experience.

    PubMed

    Kim, Chae Young

    2016-08-01

    Granville Stanley Hall (1844-1924) with William James (1842-1910) is the key founder of psychology of religion movement and the first American experimental or genetic psychologist, and Carl Gustav Jung (1875-1961) is the founder of the analytical psychology concerned sympathetically about the religious dimension rooted in the human subject. Their fundamental works are mutually connected. Among other things, both Hall and Jung were deeply interested in how the study of religious experience is indispensable for the depth understanding of human subject. Nevertheless, except for the slight indication, this common interest between them has not yet been examined in academic research paper. So this paper aims to articulate preliminary evidence of affinities focusing on the locus and its function of the inner deep psychic dimension as the religious in the work of Hall and Jung.

  17. "Decknamen or pseudochemical language"? Eirenaeus Philalethes and Carl Jung.

    PubMed

    Newman, W R

    1996-01-01

    It is impossible to investigate the historiography of alchemy without encountering the ideas of the "father of analytical psychology", Carl Jung. Jung argued that alchemy, viewed as a diachronic, trans-cultural entity, was concerned more with psychological states occurring in the mind of the practitioner than with real chemical processes. In the course of elucidating this idea, Jung draws on a number of alchemical authors from the early modern period. One of these is Eirenaeus Philalethes, the pen name of George Starkey (1628-1665), a native of Bermuda who was educated at Harvard College, and who later immigrated to London. A careful analysis of Starkey's work shows, however, that Jung was entirely wrong in his assessment of this important representative of seventeenth-century alchemy. This finding casts serious doubt on the Jungian interpretation of alchemy as a whole.

  18. Existential perspective in the thought of Carl Jung.

    PubMed

    Shelburne, W A

    1983-03-01

    It is argued that there is a significant existential perspective in the thought of Carl Jung. Similarities and differences with some of the views of Jean Paul Sartre are explored as a way of developing this perspective and to show how a philosophy of a man might be developed drawing from both sources. Jung is shown to be in disagreement with Sartre in defending an idea of a determinate human nature, describing the self in a developmental way, and in not claiming that human freedom is absolute or unconditioned. Nevertheless, the Jungian concept of individuation is similar to Sartre's ideal of authenticity, in that both focus on the goal of achieving meaningful existence through development of inner resources, creative exercise of freedom, and overcoming self-deception.

  19. Carl Rogers and the larger context of therapeutic thought.

    PubMed

    Wachtel, Paul L

    2007-09-01

    Carl Rogers' classic account (see record 2007-14639-002) of the necessary and sufficient conditions for therapeutic personality change is examined in light of developments in theory and practice since the time he wrote. Rogers' ideas, which diverged from and were very largely a challenge to, the dominant psychoanalytic ideology of the era in which he wrote, are considered in relation to new theoretical developments in what has come to be called relational psychoanalysis. They are also considered in light of the greatly increased influence of and substantial evidence supporting behavioral and cognitive-behavioral approaches. Points of convergence and divergence among these approaches are examined. (PsycINFO Database Record (c) 2010 APA, all rights reserved). PMID:22122253

  20. Richard von Volkmann

    PubMed Central

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R.

    2008-01-01

    Richard von Volkmann (1830–1889), one of the most important surgeons of the 19th century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867–1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the “antiseptic technique” to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann’s contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children’s fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics. PMID:18196438

  1. [Carl Gustav Jung: promotion records. Documents from the state archives of the Zurich canton].

    PubMed

    Wilhelm, H R

    1995-01-01

    Two documents dated 1902 show Eugen Bleuler as the supervisor of Carl Gustav Jung's thesis. In his expert opinion Bleuler declares himself convinced of the high scientific qualities of Jung. PMID:8658591

  2. 78 FR 24394 - Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical Education... comments here. SUPPLEMENTARY INFORMATION: The Department of Education (ED), in accordance with the... information collection request (ICR) that is described below. The Department of Education is...

  3. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the astronautics lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics lab.

  4. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for Planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the Astronautics Lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics Lab.

  5. Mendelian inheritance in Germany between 1900 and 1910. The case of Carl Correns (1864-1933).

    PubMed

    Rheinberger, H J

    2000-12-01

    Carl Correns (1864-1933) came to recognize Mendel's rules between 1894 and 1900 while trying to find out the mechanism of xenia, that is, the direct influence of the fertilizing pollen on the mother plant in maize and peas among other species. In this paper, I am concerned with the ten years of Correns' work after the annus mirabilis of 1900 until 1910, when the main outlines of the new science of genetics had been established. It is generally assumed that after 1900 Correns quickly began probing the limits of Mendelian inheritance, both as far as the explanatory force of formal transmission genetics and the generality of Mendel's laws are concerned. A careful examination of his papers however shows that he was much more interested in the scope of Mendelian inheritance than in its limits. Even his work with variegated Mirabilis plants, which historiographical folklore still presents as a result of Correns' growing interest in cytoplasmic inheritance, can be shown to have been conducted to corroborate just the opposite, namely, the validity of the nuclear paradigm. The paper will show that Correns' research results in those years (among them the Mendelian inheritance of sex in higher plants) were the outcome of a complex experimental program which involved breeding experiments with dozens of different species.

  6. Mendelian inheritance in Germany between 1900 and 1910. The case of Carl Correns (1864-1933).

    PubMed

    Rheinberger, H J

    2000-12-01

    Carl Correns (1864-1933) came to recognize Mendel's rules between 1894 and 1900 while trying to find out the mechanism of xenia, that is, the direct influence of the fertilizing pollen on the mother plant in maize and peas among other species. In this paper, I am concerned with the ten years of Correns' work after the annus mirabilis of 1900 until 1910, when the main outlines of the new science of genetics had been established. It is generally assumed that after 1900 Correns quickly began probing the limits of Mendelian inheritance, both as far as the explanatory force of formal transmission genetics and the generality of Mendel's laws are concerned. A careful examination of his papers however shows that he was much more interested in the scope of Mendelian inheritance than in its limits. Even his work with variegated Mirabilis plants, which historiographical folklore still presents as a result of Correns' growing interest in cytoplasmic inheritance, can be shown to have been conducted to corroborate just the opposite, namely, the validity of the nuclear paradigm. The paper will show that Correns' research results in those years (among them the Mendelian inheritance of sex in higher plants) were the outcome of a complex experimental program which involved breeding experiments with dozens of different species. PMID:11147095

  7. The Roosevelt years: crucial milieu for Carl Rogers' innovation.

    PubMed

    Barrett-Lennard, Godfrey T

    2012-02-01

    This study explores broad features of political culture and event of the 1930s and World War 2 years, viewed in relation to the emergence and rapid early growth of the new therapy of Carl Rogers. The paper traces Rogers' early professional life and examines distinctive emphases in sociopolitical thought and development during Franklin D. Roosevelt's leadership as President over the prolonged emergency of the Great Depression and the crisis of the War. The study includes a focus on the President's own outlook and style, pertinent New Deal innovations, and wartime needs. Twelve features of this larger context are discriminated as together having vital importance for the new therapy and its founder. The congruent courses of the macrocontext and of Rogers' innovation are followed to the ending of Roosevelt's life. Direct causation is not attributed, but the evidence adduced newly points to particular contours of a larger environment favorable for the expression of Rogers' values and rare ability. In sum, the author concludes that a synergy of highly conducive historical circumstance and individual exceptionality contributed to the philosophical underpinnings, attitudinal values and early momentum of Rogers' client-centered therapy.

  8. Current Status of Carl Sagan Observatory in Mexico

    NASA Astrophysics Data System (ADS)

    Sanchez-Ibarra, A.

    The current status of Observatory "Carl Sagan" (OCS) of University of Sonora is presented. This project was born in 1996 focused to build a small solar-stellar observatory completely operated by remote control. The observatory will be at "Cerro Azul", a 2480 m peak in one of the best regions in the world for astronomical observation, at the Sonora-Arizona desert. The OCS, with three 16 cm solar telescopes and a 55 cm stellar telescope is one of the cheapest observatories, valuated in US200,000 Added to its scientific goals to study solar coronal holes and Supernovae Type 1A, the OCS has a strong educative and cultural program in Astronomy to all levels. At the end of 2001, we started the Program "Constelacion", to build small planetariums through all the countries with a cost of only US80,000. Also, the webcast system for transmission of the solar observations from the prototype OCS at the campus, was expanded to webcast educational programs in Astronomy since July of this year, including courses and diplomats for Latin American people. All of these advances are exposed here.

  9. The Carl Sagan solar and stellar observatories as remote observatories

    NASA Astrophysics Data System (ADS)

    Saucedo-Morales, J.; Loera-Gonzalez, P.

    In this work we summarize recent efforts made by the University of Sonora, with the goal of expanding the capability for remote operation of the Carl Sagan Solar and Stellar Observatories, as well as the first steps that have been taken in order to achieve autonomous robotic operation in the near future. The solar observatory was established in 2007 on the university campus by our late colleague A. Sánchez-Ibarra. It consists of four solar telescopes mounted on a single equatorial mount. On the other hand, the stellar observatory, which saw the first light on 16 February 2010, is located 21 km away from Hermosillo, Sonora at the site of the School of Agriculture of the University of Sonora. Both observatories can now be remotely controlled, and to some extent are able to operate autonomously. In this paper we discuss how this has been accomplished in terms of the use of software as well as the instruments under control. We also briefly discuss the main scientific and educational objectives, the future plans to improve the control software and to construct an autonomous observatory on a mountain site, as well as the opportunities for collaborations.

  10. Carl Woese, Dick Young, and the roots of astrobiology.

    PubMed

    Rummel, John D

    2014-01-01

    The beginning of the space age in the late 1950s gave rise to innovative and interdisciplinary research concepts and perspectives, including the concept of "exobiology" as a way to approach the fundamental aspects of biology through a study of life outside of the Earth, if it existed. This concept was embodied by NASA into its formal Exobiology Program and into the philosophy of the program both before and after the Viking missions that were launched to Mars to search for signs of life in 1975. Due to both management flexibility and an acceptance of the interdisciplinary nature of the problem of "life in the universe," NASA program managers, and particularly Richard S Young who ran the Exobiology Program beginning 1967, have made some excellent investments in paradigm altering science of great use both on Earth and on future space missions. The work of Carl Woese is one such example, which has revolutionized our understanding of the microbial world and the relationships of all life on Earth. PMID:24572623

  11. Carl Woese, Dick Young, and the roots of astrobiology.

    PubMed

    Rummel, John D

    2014-01-01

    The beginning of the space age in the late 1950s gave rise to innovative and interdisciplinary research concepts and perspectives, including the concept of "exobiology" as a way to approach the fundamental aspects of biology through a study of life outside of the Earth, if it existed. This concept was embodied by NASA into its formal Exobiology Program and into the philosophy of the program both before and after the Viking missions that were launched to Mars to search for signs of life in 1975. Due to both management flexibility and an acceptance of the interdisciplinary nature of the problem of "life in the universe," NASA program managers, and particularly Richard S Young who ran the Exobiology Program beginning 1967, have made some excellent investments in paradigm altering science of great use both on Earth and on future space missions. The work of Carl Woese is one such example, which has revolutionized our understanding of the microbial world and the relationships of all life on Earth.

  12. Carl Woese, Dick Young, and the roots of astrobiology

    PubMed Central

    Rummel, John D

    2014-01-01

    The beginning of the space age in the late 1950s gave rise to innovative and interdisciplinary research concepts and perspectives, including the concept of “exobiology” as a way to approach the fundamental aspects of biology through a study of life outside of the Earth, if it existed. This concept was embodied by NASA into its formal Exobiology Program and into the philosophy of the program both before and after the Viking missions that were launched to Mars to search for signs of life in 1975. Due to both management flexibility and an acceptance of the interdisciplinary nature of the problem of “life in the universe,” NASA program managers, and particularly Richard S Young who ran the Exobiology Program beginning 1967, have made some excellent investments in paradigm altering science of great use both on Earth and on future space missions. The work of Carl Woese is one such example, which has revolutionized our understanding of the microbial world and the relationships of all life on Earth. PMID:24572623

  13. The Roosevelt years: crucial milieu for Carl Rogers' innovation.

    PubMed

    Barrett-Lennard, Godfrey T

    2012-02-01

    This study explores broad features of political culture and event of the 1930s and World War 2 years, viewed in relation to the emergence and rapid early growth of the new therapy of Carl Rogers. The paper traces Rogers' early professional life and examines distinctive emphases in sociopolitical thought and development during Franklin D. Roosevelt's leadership as President over the prolonged emergency of the Great Depression and the crisis of the War. The study includes a focus on the President's own outlook and style, pertinent New Deal innovations, and wartime needs. Twelve features of this larger context are discriminated as together having vital importance for the new therapy and its founder. The congruent courses of the macrocontext and of Rogers' innovation are followed to the ending of Roosevelt's life. Direct causation is not attributed, but the evidence adduced newly points to particular contours of a larger environment favorable for the expression of Rogers' values and rare ability. In sum, the author concludes that a synergy of highly conducive historical circumstance and individual exceptionality contributed to the philosophical underpinnings, attitudinal values and early momentum of Rogers' client-centered therapy. PMID:22530376

  14. On the history of Ludwig von Bertalanffy’s “General Systemology”, and on its relationship to cybernetics – part III: convergences and divergences

    PubMed Central

    Drack, Manfred; Pouvreau, David

    2015-01-01

    Bertalanffy’s so-called “general system theory” (GST) and cybernetics were and are often confused: this calls for clarification. In this article, Bertalanffy’s conceptions and ideas are compared with those developed in cybernetics in order to investigate the differences and convergences. Bertalanffy was concerned with first order cybernetics. Nonetheless, his perspectivist epistemology is also relevant with regard to developments in second order cybernetics, and the latter is therefore also considered to some extent. W. Ross Ashby’s important role as mediator between GST and cybernetics is analysed. The respective basic epistemological approaches, scientific approaches and inherent world views are discussed. We underline the complementarity of cybernetic and “organismic” trends in systems research within the unitary hermeneutical framework of “general systemology”. PMID:26612966

  15. Programmierung von Werkzeugmaschinen

    NASA Astrophysics Data System (ADS)

    Ahrberg, Rainer; Barfels, Lutz; Voss, Jürgen

    In den 1950-er Jahren wurde am Bostoner MIT (Massachusetts Institute of Technology) die Grundlage der modernen CNC-Technik gelegt. Für die spanende Herstellung von Rotorprofilen für Hubschrauber auf Basis vorab berechneter Konturverläufe wurden erstmalig Steuerungen auf Basis diskreter elektronischer Bauelemente entwickelt. Mit der Einführung integrierter elektronischer Schaltkreise (ICs) begann diese Technologie schrittweise Einzug in die Werkzeugmaschinenindustrie zu halten. Neben der Entwicklung der Hardware wurde die Programmierung und die Entwicklung von entsprechenden Programmiersprachen ein für die Akzeptanz dieser Technologie entscheidende Größe.

  16. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    A camerman catches Dr. Wernher Von Braun, Director of the Marshall Space Flight Center, his son, Peter, and daughter, Martgrit, as they arrive at the employee picnic held to celebrate man's first landing on the moon 6 days earlier. In the foreground is David R. Newby, Director of Administration and Technical Services at the Marshall Space Flight Center.

  17. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

  18. Analytik von Lebensmittelallergenen

    NASA Astrophysics Data System (ADS)

    Demmel, Anja; Hahn, Alexandra

    Ansonsten harmlose Lebensmittel oder deren Bestandteile können bei von Lebensmittelallergien betroffenen Personen Überempfindlichkeitsreaktionen auslösen. Hierbei kann es sich um immunvermittelte Lebensmittelallergien oder um Intoleranzen gegenüber bestimmten Lebensmittelbestandteilen handeln. Ein Beispiel für Letzteres ist die Laktoseintoleranz, welche durch einen Enzymdefekt hervorgerufen wird [1]. Im Gegensatz hierzu handelt es sich bei Lebensmittelallergien um Sofortreaktionen, die durch IgE-Antikörper gegen Antigene aus den Lebensmitteln hervorgerufen werden und zu verschiedenen körperlichen Beschwerden führen können. Bei den Antigenen, welche von den von Allergikern produzierten IgE-Antikörpern erkannt werden, handelt es sich vor allem um Proteine [2]. Symptome IgE-vermittelter Reaktionen können zum Beispiel Hautausschlag, eine Schwellung der Schleimhäute oder das sogenannte orale Allergiesyndrom mit allergischen Reaktionen an der Mundschleimhaut und im Magen-Darm-Trakt sein [3]. Die hierbei auftretenden Beschwerden reichen von einem Brennen im Mund und einer Schwellung der Lippen und der Zunge bis zu Atemnot verursachenden Schwellungen im Kehlkopfbereich. In besonders schlimmen Fällen können allergische Reaktionen zu einem anaphylaktischen Schock und zum Tod durch Kreislaufversagen führen [4]. Während klassische Nahrungsallergene häufig komplexe Reaktionen zur Folge haben, ist bei Pollen-assoziierten Nahrungsmittelallergien das orale Allergiesyndrom vorherrschend.

  19. Energetische Verwertung von Biomasse

    NASA Astrophysics Data System (ADS)

    Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    Etwa 0,1% der Solarenergie wandeln sich durch Photosynthese aus dem Kohlendioxid der Luft in Biomasse um. Die Biomassen sind als Festbrennstoff nutzbar oder zu gasförmigen Brennstoffen weiterverarbeitbar. Zwei Arten von Biomassen sind zu unterscheiden: Anfallende Biomasse

  20. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher von Braun, Director of the Marshall Space Flight Center, explains the purpose of a thermal curtain in the mockup of a Saturn I workshop to U.S. Representative Armistead Seldon of Alabama. The Congressman visited the Marshall Center on March 2, 1968 to tour the workshop and to visit Marshall Center facilities.

  1. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    U.S. Representative Armistead Seldon (D.-Al) inspects the food preparation area of the Saturn I workshop mockup during a visit to the Marshall Space Flight Center. Explaining the operation of the food preparation area to the congressman is Dr. Wernher Von Braun, Marshall Space Flight Center director.

  2. Neurological Management of Von Hippel-Lindau Disease.

    PubMed

    Hodgson, Trent S; Nielsen, Sarah M; Lesniak, Maciej S; Lukas, Rimas V

    2016-09-01

    Von Hippel-Lindau disease is a genetic condition due to mutation of the Von Hippel-Lindau gene, which leads to an increased risk in the development of hemangioblastomas of the brain and spinal cord. The pathophysiology of disease and its clinical manifestations, as they pertain to the general neurologist, are discussed. Therapeutic management of central nervous system hemangioblastomas ranging from neurosurgical resection, radiation therapy, and systemic therapies is reviewed. PMID:27564075

  3. [Tone psychology and music research as catalysts of experimental-scientific practice and methodology in the circle of Carl Stumpf].

    PubMed

    Klotz, Sebastian

    2008-09-01

    The study of acoustics, harmonics and of music has been providing scientific models since Greek Antiquity. Since the early modern ages, two separate cultures began to emerge out of the study of music: a technical acoustics and an aesthetically and philosophically inspired musical criticism. In the writings of Johann Friedrich Herbart (1811) a scientific approach to musical aesthetics and to music perception is taking shape that reinstalls the listening process as a highly complex and logical phenomenon. By opening music for a scientific psychological investigation, Herbart pioneered the physiologically and acoustically grounded seminal work by Hermann von Helmholtz On the sensations of tone (1863) which the author considered a prerequisite for musical aesthetics and music theory. Helmholtz in turn inspired the philosopher and psychologist Carl Stumpf to further investigate musical perception (beginning in 1883). To Stumpf, it provided a paradigm for experimental psychology as mental functions and phenomena could be studied in detail. These functions and phenomena are the actual objects of scientific study in Stumpf's inductive and descriptive psychology. Combining insights from statistics, ethnology, anthropology, psychoacoustics and the cultural history of mankind, Stumpf and his team developed a new blend of science which absorbs styles of reasoning, analytical procedures and academic convictions from natural history, the natural sciences and the humanities but at the same time identifies shortcomings of these approaches that fail to grasp the complexities of psychic functions. Despite their reliance on the quasi-objective phonograph and despite their commitment to objectivity, precision and measurement, mental phenomena relating to tonal perception and to music provided too complex a challenge to be easily articulated and shared by the scientific community after 1900. The essay illustrates these tensions against the background of a history of objectivity.

  4. Dr. von Braun at 'Wernher von Braun Day' Celebration

    NASA Technical Reports Server (NTRS)

    1970-01-01

    In 1970 Marshall Space Flight Center (MSFC) Director Dr. Wernher von Braun (right) was reassigned to NASA Headquarters to serve as Deputy Associate Administrator for Plarning. Prior to his transfer, Dr. von Braun was honored for his career in Huntsville, Alabama, with the celebration of 'Wernher von Braun Day.' Among those participating were Alabama Governor Albert Brewer (left) and Alabama Senator John Sparkman (center). (Courtesy of Huntsville/Madison County Public library)

  5. Optimierung von Kommunikationsnetzen

    NASA Astrophysics Data System (ADS)

    Eberspächer, Jörg; Kiese, Moritz; Wessäly, Roland

    Die weltweiten Telekommunikationsnetze (Telefon-, Mobilfunknetze, Internet) bilden heute das Nervensystem von Wirtschaft und Gesellschaft. Durch den anhaltenden technologischen Fortschritt in der Elektronik, der Computer- und Kommunikationstechnik steigt nicht nur die Zahl der Teilnehmer in den Netzen ständig, sondern es entstehen auch laufend neue Anwendungen, wie Radio und Fernsehen im Internet, elektronischer Handel und interaktive Spiele im Internet. Auf den Kupfer- und Glasfaserkabeln sowie den Funkstrecken werden gigantische Informationsmengen transportiert. Das Verkehrs-wachstum ist nach wie vor exponentiell.

  6. Psyche=singularity: A comparison of Carl Jung's transpersonal psychology and Leonard Susskind's holographic string theory

    NASA Astrophysics Data System (ADS)

    Desmond, Timothy

    In this dissertation I discern what Carl Jung calls the mandala image of the ultimate archetype of unity underlying and structuring cosmos and psyche by pointing out parallels between his transpersonal psychology and Stanford physicist Leonard Susskind's string theory. Despite his atheistic, materialistically reductionist interpretation of it, I demonstrate how Susskind's string theory of holographic information conservation at the event horizons of black holes, and the cosmic horizon of the universe, corroborates the following four topics about which Jung wrote: (1) his near-death experience of the cosmic horizon after a heart attack in 1944; ( 2) his equation relating psychic energy to mass, "Psyche=highest intensity in the smallest space" (1997, 162), which I translate into the equation, Psyche=Singularity; (3) his theory that the mandala, a circle or sphere with a central point, is the symbolic image of the ultimate archetype of unity through the union of opposites, which structures both cosmos and psyche, and which rises spontaneously from the collective unconscious to compensate a conscious mind torn by irreconcilable demands (1989, 334-335, 396-397); and (4) his theory of synchronicity. I argue that Susskind's inside-out black hole model of our Big Bang universe forms a geometrically perfect mandala: a central Singularity encompassed by a two-dimensional sphere which serves as a universal memory bank. Moreover, in precise fulfillment of Jung's theory, Susskind used that mandala to reconcile the notoriously incommensurable paradigms of general relativity and quantum mechanics, providing in the process a mathematically plausible explanation for Jung's near-death experience of his past, present, and future life simultaneously at the cosmic horizon. Finally, Susskind's theory also provides a plausible cosmological model to explain Jung's theory of synchronicity--meaningful coincidences may be tied together by strings at the cosmic horizon, from which they

  7. Carl Albert State College Drug-Free School and Community Policy.

    ERIC Educational Resources Information Center

    Carl Albert State Coll., Poteau, OK.

    This pamphlet, designed for distribution to students and employees of Carl Albert State College, Oklahoma, reviews the risks associated with alcohol and drug use and establishes standards of conduct relating to drug use. The section detailing health risks covers overdoses, chemical dependency, ill health, and the accidents which can result from…

  8. The Coconstruction of Congruency: Investigating the Conceptual Metaphors of Carl Rogers and Gloria.

    ERIC Educational Resources Information Center

    Wickman, Scott A.; Campbell, Cynthia

    2003-01-01

    The counseling session between Carl Rogers and Gloria is one of the most widely used teaching tools in the field of counselor education. This article explores a framework for investigating conceptual metaphor, which provided a useful method for understanding how meaning negotiation took place within the session as well as how Rogers and Gloria…

  9. The Application of Carl Rogers' Person-Centered Learning Theory to Web-Based Instruction.

    ERIC Educational Resources Information Center

    Miller, Christopher T.

    This paper provides a review of literature that relates research on Carl Rogers' person-centered learning theory to Web-based learning. Based on the review of the literature, a set of criteria is described that can be used to determine how closely a Web-based course matches the different components of Rogers' person-centered learning theory. Using…

  10. Carl Rogers's Life and Work: An Assessment on the 100Th Anniversary of His Birth

    ERIC Educational Resources Information Center

    Kirschenbaum, Howard

    2004-01-01

    This article summarizes the life and work of America's most influential counselor and psychotherapist, Carl Rogers. He developed the client-centered, person-centered approach; popularized the term client; pioneered the recording of counseling cases; conducted landmark research on counseling and psychotherapy; and was a leader in the humanistic…

  11. Education for the 1980s and Beyond: An Interview with Carl Rogers.

    ERIC Educational Resources Information Center

    Robinson, Edward H., III

    1985-01-01

    Presents an interview with Carl Rogers regarding education today and what it could be in the future. Discusses topics including politics and power, free choice versus conservatism, censorship, facilitators of learning, knowledge children need in today's world, and the changing society as it relates to humanistic education. (BH)

  12. An Analysis of How Carl Rogers Enacted Client-Centered Conversation with Gloria.

    ERIC Educational Resources Information Center

    Wickman, Scott A.; Campbell, Cynthia

    2003-01-01

    This study analyzed Carl Rogers's session with Gloria in "Three Approaches to Psychotherapy" to determine how Rogers's conversational style functioned to enact his core conditions of empathy, genuineness, and unconditional positive regard. Rogers's conversational style was found to be congruent with his espoused theory as well as a catalyst for…

  13. Frontiers in Laser Cooling, Single-Molecule Biophysics, and Enrgy Science: A Talk by Carl Wieman

    ScienceCinema

    Wieman, Carl

    2016-07-12

    Carl Wieman presents a talk at Frontiers in Laser Cooling, Single-Molecule Biophysics and Energy Science, a scientific symposium honoring Steve Chu, director of Lawrence Berkeley National Laboratory and recipient of the 1997 Nobel Prize in Physics. The symposium was held August 30, 2008 in Berkeley.

  14. Carl D. Perkins Vocational and Applied Technology Education Act as Amended.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC.

    This document contains the text of the Carl D. Perkins Vocational and Applied Technology Education Act, as amended. Title I, Vocational Education Assistance to the States, has two parts: Allotment and Allocation, and STate Organizational and Planning Responsibilities. Title II, Basic State Grants for Vocational Education, contains three parts:…

  15. 78 FR 39715 - Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical Education... do not send comments here. SUPPLEMENTARY INFORMATION: The Department of Education (ED), in accordance... burden of this collection on the respondents, including through the use of information technology....

  16. A View of the Symbolic-Experiential Family Therapy of Carl Whitaker through Movie Analysis

    ERIC Educational Resources Information Center

    Cag, Pinar; Voltan Acar, Nilufer

    2015-01-01

    The movie "Ya Sonra" is evaluated in respect to the basic concepts and principles of symbolic-experiential family therapy. Carl Whitaker, who called his approach "Psychotherapy of Absurdity" mainly emphasized the concepts of absurdity, experientiality, and symbolism. Based on the hypothesis that film analysis supports and…

  17. Carl: A Case Study of a Gifted Student with Challenging Social Behaviors

    ERIC Educational Resources Information Center

    Zapotocky, Robin

    2014-01-01

    Robin Zapotocky is a first-year teacher in a fifth-grade classroom at Cannaday Elementary in Mesquite ISD, Mesquite TX. She graduated from Baylor University in the gifted and elementary dual certificate program, and first met Carl when she was student teaching in a gifted and talented pullout program for third- and fourth-grade gifted students.…

  18. Carl Gawboy, Ojibwe Regional Painter. With Teacher's Guide. Native Americans of the Twentieth Century.

    ERIC Educational Resources Information Center

    Minneapolis Public Schools, MN.

    A biography for the elementary grades of Carl Gawboy (Ojibwe), an American Indian painter, includes photographs of the artist and some of his work. A teacher's guide following the bibilography contains information on watercolor painting and the Ojibwe people, learning objectives and study questions, instructions for doing a watercolor painting and…

  19. The life of Carl Beck and an important interval with Alexis Carrel.

    PubMed

    Baader, W; Nyhus, L M

    1986-07-01

    Carl Beck was a surgeon associated with the University of Illinois College of Medicine between 1898 and 1917. With Alexis Carrel, Beck developed an operation that used the stomach for replacement of the esophagus. Beck had an illustrious career and a close personal and professional relationship with Carrel.

  20. Carl D. Perkins Vocational and Applied Technology Education Amendments of 1998. Public Law 105-332.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC.

    This document contains the text of the Carl D. Perkins Vocational and Applied Technology Education Amendments of 1998. The following are among the aspects of Title I of the 1990 Perkins Act (Vocational and Technical Education Assistance to the States) that are addressed in the amendments: allotment and allocation (reservations and state allotment,…

  1. The Final Regulations to the Carl D. Perkins Vocational and Applied Technology Education Act of 1990.

    ERIC Educational Resources Information Center

    American Vocational Association, Alexandria, VA.

    This publication presents the final regulations to the Carl D. Perkins Vocational and Applied Technology Education Act of 1990. The first section is an analysis of the regulations. This analysis compares the proposed regulations to the final version and explains the differences between the two and the potential impact on program administration.…

  2. Astronaut Carl Walz changes out film magazine on the IMAX camera

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut Carl E. Walz, mission specialist, changes out a film magazine on the IMAX camera. The camera was one of two IMAX cameras carried aboard the Discovery. The procedure was carried out in the middeck. A sleep restraint forms a backdrop for the action.

  3. Critical Challenges in California Community Colleges: An Interview with Carl Ehmann

    ERIC Educational Resources Information Center

    Frost, Robert A.

    2009-01-01

    This interview took place in several meetings over a period of two weeks in late spring, 2008. Carl Ehmann had spent the past five months working with multiple California community college districts to resolve numerous, and multilevel, shortages in senior leadership positions. Robert A. Frost and Ehmann had come into contact through Frost's…

  4. Consortia Formation and Characteristics under the "Carl D. Perkins Career and Technical Education Act of 2006"

    ERIC Educational Resources Information Center

    Staklis, Sandra; Klein, Steve

    2014-01-01

    The "Carl D. Perkins Career and Technical Education Act of 2006" ("Perkins IV") sets a minimum allocation requirement that secondary and postsecondary career and technical education (CTE) subgrantees must achieve to receive federal financing. An eligible recipient with an allocation below the funding threshold may obtain a…

  5. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

  6. Generalized Imitation and Orff-Schulwerk

    ERIC Educational Resources Information Center

    Ball, Thomas S.; Bitcon, Carol H.

    1974-01-01

    Carl Orff's procedure of using elemental music in learning through discovery (Schulwerk) was tested for its effect in developing generalized imitative behaviors in 16 severely retarded Ss (mean chronological age was 17.8 years for experimental Ss and 16.5 years for control Ss). (GW)

  7. A Dialogue with Carl Rogers: Cross-Cultural Challenges of Facilitating Person-Centered Groups in Africa.

    ERIC Educational Resources Information Center

    Hain-Hill, Alicia; Rogers, Carl R.

    1988-01-01

    Presents brainstorming dialogue with Carl Rogers which was held in January of 1987, shortly before Rogers's death. Explores basic challenges involved in a large-scale, cross-cultural application of person-centered group work in South Africa. (Author)

  8. Carl B. Camras, MD: reflections on his contributions to glaucoma research and clinical practice.

    PubMed

    Camras, Nancy L

    2012-11-01

    My husband, Carl B. Camras, MD (chairman of the Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha), died at age 55 years in 2009. His dying wish was to be remembered for being the first to hypothesize that prostaglandins lower intraocular pressure and had potential as a medication to treat glaucoma. I reviewed the research he performed as an undergraduate at Yale University (New Haven, Connecticut), as a medical student at Columbia University (New York, New York), and on the faculty at Mount Sinai School of Medicine (New York, New York), which confirmed his hypothesis and led to the development of latanoprost. This article summarizes his contributions to glaucoma research, his role in the development of latanoprost, and the error of omission that prevented his recognition as its coinventor. Carl is best remembered as an ethical scientist, a gifted clinician, and a beloved teacher, who inspired the medical community and the next generation of ophthalmologists. PMID:23143447

  9. Feeling our way into empathy: Carl rogers, Heinz Kohut, and Jesus.

    PubMed

    Goodman, G

    1991-09-01

    Throughout their academic careers Carl Rogers and Heinz Kohut developed two contrasting definitions of empathy that influenced the ways in which both men sought to help their clients cope with emotional suffering. These two different understandings of empathy are contrasted to each other and finally compared with the understanding of empathy demonstrated in the teachings and actions of Jesus. It is hoped that through studying these ancient religious narratives we might be able to recover a deeper meaning of empathy.

  10. Feeling our way into empathy: Carl rogers, Heinz Kohut, and Jesus.

    PubMed

    Goodman, G

    1991-09-01

    Throughout their academic careers Carl Rogers and Heinz Kohut developed two contrasting definitions of empathy that influenced the ways in which both men sought to help their clients cope with emotional suffering. These two different understandings of empathy are contrasted to each other and finally compared with the understanding of empathy demonstrated in the teachings and actions of Jesus. It is hoped that through studying these ancient religious narratives we might be able to recover a deeper meaning of empathy. PMID:24272670

  11. Wolfgang von Ohnesorge

    NASA Astrophysics Data System (ADS)

    McKinley, Gareth H.; Renardy, Michael

    2011-12-01

    This manuscript got started when one of us (G.H.M.) presented a lecture at the Institute of Mathematics and its Applications at the University of Minnesota. The presentation included a photograph of Rayleigh and made frequent mention of the Ohnesorge number. When the other of us (M.R.) enquired about a picture of Ohnesorge, we found out that none were readily available on the web. Indeed, little about Ohnesorge is available from easily accessible public sources. A good part of the reason is certainly that, unlike other "numbermen" of fluid mechanics, Ohnesorge did not pursue an academic career. The purpose of this article is to fill the gap and shed some light on the life of Wolfgang von Ohnesorge. We shall discuss the highlights of his biography, his scientific contributions, their physical significance, and their impact today.

  12. Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

    PubMed Central

    LaMonte, Gregory; Lim, Michelle Yi-Xiu; Wree, Melanie; Reimer, Christin; Nachon, Marie; Corey, Victoria; Gedeck, Peter; Plouffe, David; Du, Alan; Figueroa, Nelissa; Yeung, Bryan; Winzeler, Elizabeth A.

    2016-01-01

    ABSTRACT Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-stage parasites. Here, we show that pfcarl encodes a protein, with a predicted molecular weight of 153 kDa, that localizes to the cis-Golgi apparatus of the parasite in both asexual and sexual blood stages. Utilizing clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene introduction of 5 variants (L830V, S1076N/I, V1103L, and I1139K), we demonstrate that mutations in pfcarl are sufficient to generate resistance against the imidazolopiperazines in both asexual and sexual blood-stage parasites. We further determined that the mutant PfCARL protein confers resistance to several structurally unrelated compounds. These data suggest that PfCARL modulates the levels of small-molecule inhibitors that affect Golgi-related processes, such as protein sorting or membrane trafficking, and is therefore an important mechanism of resistance in malaria parasites. PMID:27381290

  13. Carl Levin National Defense Authorization Act for Fiscal Year 2015

    THOMAS, 113th Congress

    Sen. Levin, Carl [D-MI

    2014-06-02

    06/02/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 402. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  14. Von Hippel-Lindau Disease.

    PubMed

    Findeis-Hosey, Jennifer J; McMahon, Kelly Q; Findeis, Sarah K

    2016-06-01

    Von Hippel-Lindau disease is an autosomal dominant syndrome which occurs secondary to germline mutations in the VHL tumor suppressor gene, located on chromosome 3. Clinically von Hippel-Lindau disease is characterized by an increased risk of developing simple visceral cysts, most commonly in the pancreas and kidneys, in addition to an increased risk of developing neoplasms, often with clear cell features, in a multitude of organ systems. The most common neoplasms are cerebellar and retinal hemangioblastomas, adrenal pheochromocytomas, clear cell renal cell carcinomas, pancreatic neuroendocrine tumors, pancreatic serous cystadenomas, and endolymphatic sac tumors. These lesions most commonly present during adulthood; however, screening and surveillance for the development of these lesions should begin in the pediatric years for patients with von Hippel-Lindau disease. In this review article, the genetics and most common neoplasms of von Hippel-Lindau disease are reviewed, with an eye towards implications for the pediatric patient. PMID:27617152

  15. Pregnancy and von Gierke's disease.

    PubMed

    Farber, M; Knuppel, R A; Binkiewicz, A; Kennison, R D

    1976-02-01

    A detailed description of the course of pregnancy in a patient with von Gierke's disease is presented. Careful dietary control together with proper management of the hematologic complications of the disease led to a successful outcome. PMID:1061911

  16. von Braun and German Publisher

    NASA Technical Reports Server (NTRS)

    1969-01-01

    In this photograph, Guenter Ogger of Capitol Magazine, West Germany, greets Marshall Space Flight Center Director, Dr. Wernher von Braun. Mr. Ogger interviewed the famous rocket scientist for his magazine.

  17. Von Karman and JATO Team

    NASA Technical Reports Server (NTRS)

    1940-01-01

    Dr. Theodore von Karman (black coat) sketches out a plan on the wing of an airplane as his JATO engineering team looks on. From left to right: Dr. Clark B. Millikan, Dr.Martin Summerfield, Dr. Theodore von Karman, Dr. Frank J. Malina and pilot, Capt. Homer Boushey. Captain Boushey would become the first American to pilot an airplane that used JATO (Jet Assisted Take-Off) solid propellent rockets.

  18. Anaesthesia in Von Gierke's disease. Current approach to management.

    PubMed

    Bevan, J C

    1980-07-01

    A case report of a patient with Von Gierke's (glycogen storage disease Cori type (1)1 disease who required femoral osteotomy is presented. Current techniques of management of this condition which are likely to improve the outcome of general anaesthesia and surgery are discussed. PMID:6933867

  19. The smooth entropy formalism for von Neumann algebras

    NASA Astrophysics Data System (ADS)

    Berta, Mario; Furrer, Fabian; Scholz, Volkher B.

    2016-01-01

    We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

  20. Henry Cavendish, Johann von Soldner, and the deflection of light

    NASA Astrophysics Data System (ADS)

    Will, Clifford M.

    1988-05-01

    The gravitational deflection of light based on Newtonian theory and the corpuscular model of light was calculated, but never published, around 1784 by Henry Cavendish, almost 20 years earlier than the first published calculation by Johann Georg von Soldner. The two results are slightly different because, while Cavendish treated a light ray emitted from infinity, von Soldner treated a light ray emitted from the surface of the gravitating body. At the first order of approximation, they agree with each other; both are one-half the value predicted by general relativity and confirmed by experiment.

  1. [Carl Arthur Scheunert's experiments on human nutrition, 1938-1943: boundary transgressions of a scientist under national socialism].

    PubMed

    Joost, Hans-Georg

    2012-01-01

    Carl Arthur Scheunert (1879-1957) was a German scientist who supervised several studies with prisoners that were designed to assess the optimal vitamin and nutrient supply, and were conducted by his associate Karl-Heinz Wagner (1911-2007) from 1938 to 1943. This contribution describes the aims, results and conclusions of Scheunert's research 1923 to 1945 in comparison with the national and international vitamin research and its consequences for public health measures. Conditions and results of the human experiments are reconstructed and compared with similar studies performed in other countries. Burden as well as health risks for the study participants are assessed. In addition, it is discussed whether general rules for human experimentation were followed (e.g. informed consent and minimizing of health risks). Although the available documents support the conclusion that no deaths or lasting injuries were caused, the experiments violated ethical standards, in particular because of the conditions in the Waldheim prison including progressive deterioration of nutrition and health.

  2. Dr. Wernher Von Braun leads a tour of the S-IC checkout area.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Eberhard Rees, Charles Schultze, James Webb, Elmer Staats, Comptroller General of the United States, and Dr. Wernher Von Braun tour the S-IC checkout area in the Marshall Space Flight Center quality lab.

  3. BOOK REVIEW: Carl Christian Bruhns - Ein bedeutender Naturwissenschaftler in der zweiten Halfte des 19. Jahrhunderts

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Hansel, C.; Munzel, G.; Ilgauds, H.-J.; Borngen, M.

    2006-12-01

    The biography of the former member of the Saxonian Academy of Sciences, Carl Christian Bruhns, and appropiately published in their Transactions, originated from a series of lectures given some years ago. Gisela Munzel and Hans-Joachim Ilgauds, who have already written an authoritative history of Leipzig observatories, joined geophysicist Michael Borngen to describe various aspects of Bruhns' life and activities in different scientific fields. For the astronomical reader, Gisela Munzel's contribution is certainly the most rewarding one, and it covers almost the complete first half of the book. She not only describes Bruhns' astronomical career, but also supplies many details of his life. Having passed something equivalent to a junior high school, his father urged him to become apprentice in his own field, that of a locksmith. C.C. Bruhns became a mechanic in several companies in Berlin, and started also part-time work as a computer at Berlin Observatory in 1851. He soon was "discovered" by its director Johann Franz Encke, and became second assistant in mid-1852, first assistant in 1854 and observer in 1855. In mid-1856 he received his PhD on the topic of minor planets. A prize assignment on astronomical refraction developed into his habilitation thesis of 1859. When in 1857 the observer Heinrich d'Arrest left Leipzig Observatory, there were plans to replace him by an astronomer who would later also take over the post of the aging August Ferdinand Mobius. There were already plans to move the old Observatory on the tower of Pleissenburg castle to another location, when Bruhns was appointed observer and professor in April 1860. In Summer, construction of the new Observatory at Johannistal started, and it was inaugurated in late 1861. Munzel faithfully traces his work, his assistants and colleagues - Engelmann, Weinek, Zollner, and many more - , his activities in the founding of the Astronomische Gesellschaft, his work as a commissar of the ``Mitteleuropaische

  4. Asymptotic structure of free product von Neumann algebras

    NASA Astrophysics Data System (ADS)

    Houdayer, Cyril; Ueda, Yoshimichi

    2016-11-01

    Let $(M, \\varphi) = (M_1, \\varphi_1) \\ast (M_2, \\varphi_2)$ be the free product of any $\\sigma$-finite von Neumann algebras endowed with any faithful normal states. We show that whenever $Q \\subset M$ is a von Neumann subalgebra with separable predual such that both $Q$ and $Q \\cap M_1$ are the ranges of faithful normal conditional expectations and such that both the intersection $Q \\cap M_1$ and the central sequence algebra $Q' \\cap M^\\omega$ are diffuse (e.g. $Q$ is amenable), then $Q$ must sit inside $M_1$. This result generalizes the previous results of the first named author in [Ho14] and moreover completely settles the questions of maximal amenability and maximal property Gamma of the inclusion $M_1 \\subset M$ in arbitrary free product von Neumann algebras.

  5. Evaluation of the flathead catfish population and fishery on Lake Carl Blackwell, Oklahoma, with emphasis on the effects of noodling

    USGS Publications Warehouse

    Winkelman, Dana L.; Michaletz, Paul H.; Travnichek, Vincent H.

    2011-01-01

    I conducted a 3-year study at Lake Carl Blackwell, Oklahoma to estimate effects of various fishing gears on the flathead catfish Pylodictis olivaris population. Managers were particularly interested in the effect of handfishing or noodling on this population. I used a phone survey to assess angler effort and electrofishing and gill nets to calculate standard population metrics to assess composition of the current population. Survey data indicated that fishing effort and harvest were highest for trotlines and juglines and lowest for noodling. Size distribution of fish harvested by noodlers was not different from sizes that were available in the fishery and was similar to those fish harvested with other gears. Flathead catfish Sampled in Lake Carl Blackwell ranged in size from 38 to 1,220 mm total length, and 77% of the population was less than 508 mm (minimum legal size). Estimated total annual mortality was about 11%. Proportional size distribution (PSD) of flathead catfish for Lake Carl Blackwell indicates that about 70% of legal-sized flathead catfish were over the preferred size of 710 mm. Overall, the Lake Carl Blackwell flathead catfish population appeared healthy. There were a wide range of sizes and ages in the population, and PSD indicated a well-balanced population with many preferred and memorable-sized fish. Due to its rarity, noodling is probably not adversely influencing the population. Additionally, noodling at Lake Carl Blackwell does not appear to be as size-selective as previously thought. 

  6. The legacy of Carl Woese and Wolfram Zillig: from phylogeny to landmark discoveries.

    PubMed

    Albers, Sonja-Verena; Forterre, Patrick; Prangishvili, David; Schleper, Christa

    2013-10-01

    Two pioneers of twentieth century biology passed away during the past decade, Wolfram Zillig in April 2005 and Carl Woese in December 2012. Among several other accomplishments, Woese has been celebrated for the discovery of the domain Archaea and for establishing rRNA as the 'Rosetta Stone' of evolutionary and environmental microbiology. His work inspired many scientists in various fields of biology, and among them was Wolfram Zillig, who is credited with the discovery of several unique molecular features of archaea. In this Essay, we highlight the remarkable achievements of Woese and Zillig and consider how they have shaped the archaeal research landscape.

  7. Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution

    NASA Astrophysics Data System (ADS)

    van Dongen, Jeroen

    2012-06-01

    Albert Einstein accepted a "special" visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation involves a case of mistaken identity with Carl Einstein, Dadaist art, and a particular Dutch fear of revolutions. But what revolutions was one afraid of? The story of Einstein's Leiden chair throws new light on the reception of relativity and its creator in the Netherlands and in Germany.

  8. Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution

    NASA Astrophysics Data System (ADS)

    Dongen, Jeroen

    2012-06-01

    Albert Einstein accepted a 'special' visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation involves a case of mistaken identity with Carl Einstein, Dadaist art, and a particular Dutch fear of revolutions. But what revolution was one afraid of? The story of Einstein's Leiden chair throws new light on the reception of relativity and its creator in the Netherlands and in Germany.

  9. Carl Cohen's 'kind' arguments for animal rights and against human rights.

    PubMed

    Nobis, Nathan

    2004-01-01

    Carl Cohen's arguments against animal rights are shown to be unsound. His strategy entails that animals have rights, that humans do not, the negations of those conclusions, and other false and inconsistent implications. His main premise seems to imply that one can fail all tests and assignments in a class and yet easily pass if one's peers are passing and that one can become a convicted criminal merely by setting foot in a prison. However, since his moral principles imply that nearly all exploitive uses of animals are wrong anyway, foes of animal rights are advised to seek philosophical consolations elsewhere. I note that some other philosophers' arguments are subject to similar objections.

  10. Carl Neumann versus Rudolf Clausius on the propagation of electrodynamic potentials

    NASA Astrophysics Data System (ADS)

    Archibald, Thomas

    1986-09-01

    In the late 1860's, German electromagnetic theorists employing W. Weber's velocity-dependent force law were forced to confront the issue of energy conservation. One attempt to formulate a conservation law for such forces was due to Carl Neumann, who introduced a model employing retarded potentials in 1868. Rudolf Clausius quickly pointed out certain problems with the physical interpretation of Neumann's mathematical formalism. The debate between the two men continued until the 1880's and illustrates the strictures facing mathematical approaches to physical problems during this prerelativistic, pre-Maxwellian period.

  11. Report on von Willebrand Disease in Malaysia

    PubMed Central

    Periayah, Mercy Halleluyah; Halim, Ahmad Sukari; Saad, Arman Zaharil Mat; Yaacob, Nik Soriani; Karim, Faraizah Abdul

    2016-01-01

    BACKGROUND: Von Willebrand disease (vWD) is an inherited hemostatic disorder that affects the hemostasis pathway. The worldwide prevalence of vWD is estimated to be 1% of the general population but only 0.002% in Malaysia. AIM: Our present paper has been written to disclose the statistical counts on the number of vWD cases reported from 2011 to 2013. MATERIAL AND METHODS: This article is based on sociodemographic data, diagnoses and laboratory findings of vWD in Malaysia. A total of 92 patients were reported to have vWD in Malaysia from 2011 to 2013. RESULTS: Sociodemographic-analysis revealed that 60% were females, 63% were of the Malay ethnicity, 41.3% were in the 19-44 year old age group and 15.2% were from Sabah, with the East region having the highest registered number of vWD cases. In Malaysia, most patients are predominately affected by vWD type 1 (77.2%). Factor 8, von Willebrand factor: Antigen and vWF: Collagen-Binding was the strongest determinants in the laboratory profiles of vWD. CONCLUSION: This report has been done with great interest to provide an immense contribution from Malaysia, by revealing the statistical counts on vWD from 2011-2013. PMID:27275342

  12. [Carl Ludwig and his place in the history of kidney physiology].

    PubMed

    From, Jesper

    2015-01-01

    Only very little was known about the physiology of the kidneys until the middle of the 19th century. The turning point came in 1842 when the famous German physiologist and physician Carl Ludwig (1816-1895) presented a theory about a two-step process (filtration and reabsorption) leading to the excretion of urine. This paper turns the highlights on Ludwig and the period in which he lived. It also tells the story about the anatomical studies in the 17th century and the chemical approaches to urine and kidney physiology in the 18th century preceding the research of Carl Ludwig. The theory of filtration and reabsorption was opposed by another theory (the secretion theory) regarding the kidney as a gland, like for instance the salivary glands. The origin of this theory can be dated back to Marcello Malpighi (1628-1694) in the Renaissance, but it was carried further on by William Bowman (1816-1892) and especially Rudolph Heidenhain (1834-1897) in the 19th century. The research in the 1920's and 1930's marked the end of the fight between the two theories. It proofed that Ludwig was right and it gave him posthumously the recognition that he all the time had deserved.

  13. von Willebrand Disease (For Parents)

    MedlinePlus

    ... Type 2A or Type 2B. People with Type 3 (and some with Type 2A and 2B) will need treatment with Humate-P, an intravenous medication derived from human plasma that contains factor VIII and von Willebrand factor. ...

  14. Carl Jung.

    PubMed

    Kyle, R A; Shampo, M A

    1978-11-17

    Physicians should be prepared to provide prophylactic medications for travelers to malarious areas and to treat patients with malaria. Chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquine-resistant strains of Plasmodium falciparum. For treatment of severe infections with P falciparum and for treatment of all infections due to chloroquine-resistant strains of P falciparum quinine is the suppressive agent of choice. Chloroquine is also the prophylactic agent of choice for most travelers. To prevent infection with P vivax or P ovale, primaquine must also be given. A RBC glucose-6-phosphate dehydrogenase level should be obtained before administration of primaquine. For prophylaxis of chloroquine-resistant strains of P falciparum, no completely satisfactory regime is presently available in the United States.

  15. Little known ophthalmic interests of Emil von Behring, the first Nobel Prize Laureate in Medicine or Physiology.

    PubMed

    Grzybowski, Andrzej; Wilhelm, Helmut

    2013-06-01

    Although the work for which Emil von Behring (1854-1917) was awarded the first Nobel Prize Winner for Medicine or Physiology in 1901 was on serum therapy, not only was he trained and worked as an ophthalmologist but he also wrote his doctoral dissertation on a practical ophthalmological topic whilst in Berlin under Carl Schweigger (1830-1905). He later worked for 3 years as an assistant and co-worker with the famous Polish ophthalmologist Boleslaw Wicherkiewicz (1847-1915), in Poznan where he described an interesting ophthalmic case in a scientific journal. His life and work in other fields have been well studied, but his interests and relationship to ophthalmology that played an important role in, at least part of, Behring's life have never previously been analysed thoroughly.

  16. Carl Rogers' Responses in the 17th Session with Miss Mun: Comments from a Process-Experiential and Psychoanalytic Perspective.

    ERIC Educational Resources Information Center

    Gundrum, Monica; Lietaer, Germain; Van Hees-Matthijssen, Christiane

    1999-01-01

    Reproduces the transcript of one of Carl Rogers' filmed therapeutic sessions with Miss Mun, followed by an empirical and clinical-qualitative analysis. Five task oriented processes are examined in detail: the evocative impact of reflections of feeling; empathic affirmation as a marker of intense vulnerability; focusing reflections; working with…

  17. The Unifying Function of Affect: Founding a Theory of Psychocultural Development in the Epistemology of John Dewey and Carl Jung

    ERIC Educational Resources Information Center

    Dunlap, Peter T.

    2012-01-01

    In this paper I explore the shared interest of John Dewey and Carl Jung in the developmental continuity between biological, psychological, and cultural phenomena. Like other first generation psychological theorists, Dewey and Jung thought that psychology could be used to deepen our understanding of this continuity and thus gain a degree of control…

  18. The Legal and Fiscal Disjunction between the Carl Perkins Vocational Education Act and the Job Training Partnership Act. Monograph Series.

    ERIC Educational Resources Information Center

    Brustein, Michael

    The Carl D. Perkins Vocational Education Act and the Job Training Partnership Act (JTPA) contain several inconsistent fiscal and legal requirements. The federal legal framework governing expenditure of funds under the Perkins Act and JTPA is voluminous and cumbersome, but no effort has been undertaken to maintain a coherent legal resource covering…

  19. Roadmap to Perkins III: The Carl D. Perkins Vocational and Technical Education Act of 1998. A Guidebook for Illinois.

    ERIC Educational Resources Information Center

    Hess-Grabill, Donella; Bueno, Soyon

    This guidebook is intended as a road map to the Carl D. Perkins Vocational Technical Education Act of 1998 (Perkins III) for career-technical education (CTE) practitioners and policymakers in Illinois. The following topics are among those covered: (1) framework for Perkins III (national educational reform, Illinois provisions for quality CTE,…

  20. Dr. Wernher Von Braun at the launch of Apollo 11.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Mission officials relax, all smiles, a few moments after the successful launch of the Apollo 11 spacecraft by Saturn V vehicle AS-506. Relieved of the tension of waiting through the countdown are (left to right) Charles W. Matthews, NASA deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Director of the Marshall Space Flight Center; Dr. George E. Meuller, NASA associate administrator for manned spaceflight, and Lt. General Samuel C. Phillips, director of the Apollo program.

  1. Canary Island Group and von Karman Cloud Vortices.

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Tis image shows a part of the Canary Island Group (28.0N, 16.0W) located just west of the NW coast of Africa. Low level stratus clouds often form here and become trapped in vertical movement because of an overlaying temperature inversion. The islands create a disturbance in the wind flow, generally from the north or northeast, that create distinctive cloud swirls known as von Karman Cloud Vortices on the downstream side of the island.

  2. [Matter and spirit: the unconscious in Carl Gustav Carus's psychology (1779-1868)].

    PubMed

    Montiel, L

    1997-01-01

    Carl Gustav Carus, one of the originators of a doctrine centered on the unconscious, is an interesting figure from current viewpoints. The doctrine he espoused was psychological, but in addition, the author sought foundations for his thinking in the biological knowledge of his time. The unconscious that Carus postulated was simultaneously biological, material and psychological in nature. Thus the history of psychism--the history of the soul--was related with the individual's and the species's biological history. From this perspective the unconscious was recognized as an indispensable element of rational thought. This theory, which recalls in many aspects that of C.G. Jung, made possible the medical study of psychic life and the revaluation of unconscious factors of psychism which were usually denigrated by modern anthropologists and moralists. PMID:11623549

  3. Similarities between Prescott Lecky's theory of self-consistency and Carl Rogers' self-theory.

    PubMed

    Merenda, Peter F

    2010-10-01

    The teachings of Prescott Lecky on the self-concept at Columbia University in the 1920s and 1930s and the posthumous publications of his book on self-consistency beginning in 1945 are compared with the many publications of Carl Rogers on the self-concept beginning in the early 1940s. Given that Rogers was a graduate student at Columbia in the 1920s and 1930s, the striking similarities between these two theorists, as well as claims attributed to Rogers by Rogers' biographers and writers who have quoted Rogers on his works relating to self-theory, strongly suggest that Rogers borrowed from Lecky without giving him the proper credit. Much of Rogers' writings on the self-concept included not only terms and concepts which were original with Lecky, but at times these were actually identical.

  4. Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora

    NASA Astrophysics Data System (ADS)

    Saucedo-Morales Julio; Loera-González, Pablo

    2013-05-01

    We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects.

  5. Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora

    PubMed Central

    Saucedo-Morales, Julio; Loera-González, Pablo

    2013-01-01

    We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects. PMID:25685436

  6. [Matter and spirit: the unconscious in Carl Gustav Carus's psychology (1779-1868)].

    PubMed

    Montiel, L

    1997-01-01

    Carl Gustav Carus, one of the originators of a doctrine centered on the unconscious, is an interesting figure from current viewpoints. The doctrine he espoused was psychological, but in addition, the author sought foundations for his thinking in the biological knowledge of his time. The unconscious that Carus postulated was simultaneously biological, material and psychological in nature. Thus the history of psychism--the history of the soul--was related with the individual's and the species's biological history. From this perspective the unconscious was recognized as an indispensable element of rational thought. This theory, which recalls in many aspects that of C.G. Jung, made possible the medical study of psychic life and the revaluation of unconscious factors of psychism which were usually denigrated by modern anthropologists and moralists.

  7. Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora.

    PubMed

    Saucedo-Morales, Julio; Loera-González, Pablo

    2013-05-01

    We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects. PMID:25685436

  8. Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora.

    PubMed

    Saucedo-Morales, Julio; Loera-González, Pablo

    2013-05-01

    We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects.

  9. Carl Friedrich Richard Foerster (1825-1902) - the inventor of perimeter and photometer.

    PubMed

    Grzybowski, Andrzej; Sobolewska, Bianka

    2015-09-01

    Carl Friedrich Richard Foerster (1825-1902) was a German who was born in the Polish city Leszno. He studied medicine at the Medical Faculty of Breslau (now Wroclaw, Poland) University, and later in Heidelberg and Berlin. From 1855, he worked in Breslau, where he established in 1857 the first ophthalmology clinic. Later, he became a professor in ophthalmology, the first director of the Department of Ophthalmology at the University of Breslau, and even the rector of this University. Forster did many pioneering works on visual fields, invented a photometer and the first perimeter, known for many years as the Foerster perimeter. Moreover, he studied night blindness, visual field changes due to different pathologies, and many eye diseases, including glaucoma, cataract, retinal and choroidal diseases.

  10. Similarities between Prescott Lecky's theory of self-consistency and Carl Rogers' self-theory.

    PubMed

    Merenda, Peter F

    2010-10-01

    The teachings of Prescott Lecky on the self-concept at Columbia University in the 1920s and 1930s and the posthumous publications of his book on self-consistency beginning in 1945 are compared with the many publications of Carl Rogers on the self-concept beginning in the early 1940s. Given that Rogers was a graduate student at Columbia in the 1920s and 1930s, the striking similarities between these two theorists, as well as claims attributed to Rogers by Rogers' biographers and writers who have quoted Rogers on his works relating to self-theory, strongly suggest that Rogers borrowed from Lecky without giving him the proper credit. Much of Rogers' writings on the self-concept included not only terms and concepts which were original with Lecky, but at times these were actually identical. PMID:21117493

  11. Dr. von Braun Briefing Walt Disney

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  12. Untersuchungen zur Entwicklung von Satellitengalaxien

    NASA Astrophysics Data System (ADS)

    Seidel, Björn

    2002-01-01

    Gleichgewichtsmodelle ein- und zweikomponentiger Satellitengalaxien werden erzeugt und die Gezeiteneinwirkungen der als starres äußeres Potential angenommenen Milchstraße auf sie betrachtet. Eine erste Reihe von Simulationen mit anfänglich kugelsymmetrischen einkomponentigen Satelliten zeigt, daß sich nach elliptischer Deformation ein Balken und Schweife ungleicher Länge ausbilden, deren Aussehen sich periodisch ändert. Mithilfe von Vergleichssimulationen wurden folgende Phänomene am Satelliten entdeckt: (1) Hochdichtebereiche in den Schweifen, (2) Niedrigdichtebereiche um den Kern bzw. Balken und (3) ein oft verdeckter Balken. Analysiert wird das Erscheinungsbild in Zeitabhängigkeit. Die Teilchen gehen dem Kern über den Balken verloren und bewegen sich entlang gewisser stets gleich aussehender charakteristischer Strukturen in die Schweife. Nach einer Herleitung allgemeiner Größen des mehrkomponentigen Kingprofils werden drei stabile Standardmodelle zweikomponentiger Satellitengalaxien mit Massenverhältnis 1:10 (baryonische zu dunkle Materie) und unterschiedlicher Verteilung der dunklen und sichtbaren Materie gefunden. Ohne die Allgemeinheit der Ergebnisse zu beeinträchtigen, wurde dabei die Große Magellanische Wolke als Grundlage der Modelle genommen. Nach geeigneter Wahl der Bahn, zu der der Gezeitenradius des verwendeten dreikomponentigen Milchstraßenpotentials sowohl analytisch als auch numerisch berechnet wird, werden Simulationen der Modelle analysiert. Hauptaugenmerk ist das unterschiedliche Verhalten der Komponenten. Hauptergebnisse: (1) Es ist möglich, große Anteile dunkler, jedoch nur geringe sichtbarer Materie abzulösen. Dunkle und sichtbare Materie können unterschiedliche morphologische Strukturen bilden. (2) Je nach Konzentration der Komponenten ist die Eigengravitation der Teilchen mehr oder weniger für das Aussehen bestimmend. (3) Die Kernauflösung des Satelliten findet im Perigalaktikum (PG), sein Zerfall aber erst im

  13. Reflexionseigenschaften von Windenergieanlagen im Funkfeld von Funknavigations- und Radarsystemen

    NASA Astrophysics Data System (ADS)

    Sandmann, S.; Divanbeigi, S.; Garbe, H.

    2015-11-01

    Die hier behandelte Untersuchung befasst sich mit den Störungen des elektrischen Feldes einer Doppler Very High Frequency Omnidirectional Radio Range Navigationsanlage (DVOR) in der Gegenwart von Windenergieanlagen (WEA). Hierfür wird die Feldstärke auf 25 konzentrischen Kreisbahnen, sog. Orbit Flights verschiedener Höhen und mit verschiedenen Radien rund um die DVOR-Anlage numerisch simuliert. Insbesondere werden die Einflüsse diverser Parameter der WEA wie deren Anzahl, Position, Rotorwinkel, Turmhöhe und Rotordurchmesser auf die Feldverteilung herausgestellt, sowie die Anwendbarkeit der Simulationsmethode Physical Optics (PO) durch Vergleich der Simulationsergebnisse mit denen der Multi Level Fast Multipol Method (MLFMM) untersucht.

  14. Lipid storage myopathy in von Gierke's disease: a case report.

    PubMed

    Yamaguchi, K; Santa, T; Inoue, K; Omae, T

    1978-09-01

    An 18-year-old girl with von Gierke's disease associated with a lipid storage myopathy is reported. The diagnosis of von Gierke's disease was made from decreased activity in glucose-6-phosphatase in the jejunal biopsy specimen. Neurologically she showed generalized hypotonia of the muscles, atrophy of bilateral proximal muscles of the lower extremities, weakness in neck flexors, deltoid and lumbar girdle muscles, and a positive Gower's sign. Muscle biopsy from flexor femoris muscle revealed fatty deposition in type 1 fibers and atrophy of type 2 fibers and the diagnosis of an accompanying lipid storage myopathy was made. This case also had a ventricular septal defect confirmed by right cardiac catheterization. PMID:213538

  15. Dr. Wernher Von Braun greeting dignitaries.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, left, greets vice president Spiro T. Agnew in the Launch Control Center for the Apollo 14 mission. Between Dr. Von Braun and Mr. Agnew are their Royal Highnesses, The Prince and Princess of Spain. The royal visitors greeted the launch control team in th enter after the launch of Apollo 14.

  16. Dr. Wernher Von Braun at a picnic.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, director of the Marshall Space Flight Center, stakes claim to a table for the picnic celebrating man's first lunar landing. With Dr. Von Braun are his wife, Maria (seated, right), and son, Peter (back to camera). His daughter, Margrit, was also present, but is hidden from view by friends in this view.

  17. Walt Disney and Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

  18. Ludwig von Mises: An Annotated Bibliography.

    ERIC Educational Resources Information Center

    Gordon, David

    A 117-item annotated bibliography of books, articles, essays, lectures, and reviews by economist Ludwig von Mises is presented. The bibliography is arranged chronologicaly, and is followed by an alphabetical listing of the citations, excluding books. An index and information on the Ludwig von Mises Institute at Auburn University (Alabama) are…

  19. Dr. Wernher von Braun Laid to Rest

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

  20. Dr. Wernher von Braun In His Office

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. This photo depicts von Braun in his office at MSFC.

  1. Beyond synchronicity: the worldview of Carl Gustav Jung and Wolfgang Pauli.

    PubMed

    Donati, Marialuisa

    2004-11-01

    While exploring the phenomena of synchronicity, Carl Gustav Jung became acquainted with the quantum physicist Wolfgang Pauli and eventually began a collaboration with him. During that collaboration Jung's study of synchronistic phenomena underwent a considerable change; prior to the collaboration, Jung had stressed mainly the phenomenological and empirical features of synchronistic phenomena, while in association with Pauli, he focused his attention upon their ontological, archetypal character. Pauli, on the other hand, became increasingly sensitive to the philosophical aspects concerning the unconscious. Jung and Pauli's common reflections went far beyond psychology and physics, entering into the realm where the two areas meet in the philosophy of nature. In fact, as a consequence of their collaboration, synchronicity was transformed from an empirical concept into a fundamental explanatory-interpretative principle, which together with causality could possibly lead to a more complete worldview. Exploring the problematic character of the synchronicity concept has a heuristic value because it leads to the reconsideration of the philosophical issues that drove Jung and Pauli to clear up the conceptual background of their thoughts. Within the philosophical worldview arising from Jung and Pauli's discussions about synchronicity, there are many symbolic aspects that go against mainstream science and that represent a sort of criticism to some of the commonly held views of present day science. PMID:15533199

  2. Using Carl Rogers' person-centered model to explain interpersonal relationships at a school of nursing.

    PubMed

    Bryan, Venise D; Lindo, Jascinth; Anderson-Johnson, Pauline; Weaver, Steve

    2015-01-01

    Faculty members are viewed as nurturers within the academic setting and may be able to influence students' behaviors through the formation of positive interpersonal relationships. Faculty members' attributes that best facilitated positive interpersonal relationships according to Carl Rogers' Person-Centered Model was studied. Students (n = 192) enrolled in a 3-year undergraduate nursing program in urban Jamaica were randomly selected to participate in this descriptive cross-sectional study. A 38-item questionnaire on interpersonal relationships with nursing faculty and students' perceptions of their teachers was utilized to collect data. Factor analysis was used to create factors of realness, prizing, and empathetic understanding. Multiple linear regression analysis on the interaction of the 3 factors and interpersonal relationship scores was performed while controlling for nursing students' study year and age. One hundred sixty-five students (mean age: 23.18 ± 4.51years; 99% female) responded. The regression model explained over 46% of the variance. Realness (β = 0.50, P < .001) was the only significant predictor of the interpersonal relationship scores assigned by the nursing students. Of the total number of respondents, 99 students (60%) reported satisfaction with the interpersonal relationships shared with faculty. Nursing students' perception of faculty members' realness appeared to be the most significant attribute in fostering positive interpersonal relationships.

  3. On the enduring and substantial influence of Carl Rogers' not-quite necessary nor sufficient conditions.

    PubMed

    Farber, Barry A

    2007-09-01

    Carl Rogers' 1957 paper (see record 2007-14639-002) is arguably the most successful of his many attempts to clarify and render testable the ideas behind client-centered therapy. While each of the conditions that Rogers postulated has been linked to positive therapeutic outcome, taken together they have never been conclusively proved (nor disproved) to be either necessary or sufficient for positive outcome. Nevertheless, the overriding "take-home" message in this classic paper--that the therapist's attitude and caring presence is critical for therapeutic success--is one that has had virtually unparalleled influence in every segment of the psychotherapeutic community. Clinical and theoretical innovations in the psychoanalytic community serve as examples of the following proposition: that Rogers' concepts, while accepted more than ever by a remarkably wide variety of psychotherapists, remain essentially unacknowledged as originating with him or in the tradition of humanistic and client-centered therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  4. Carl Woese's vision of cellular evolution and the domains of life

    PubMed Central

    Koonin, Eugene V

    2014-01-01

    In a series of conceptual articles published around the millennium, Carl Woese emphasized that evolution of cells is the central problem of evolutionary biology, that the three-domain ribosomal tree of life is an essential framework for reconstructing cellular evolution, and that the evolutionary dynamics of functionally distinct cellular systems are fundamentally different, with the information processing systems “crystallizing” earlier than operational systems. The advances of evolutionary genomics over the last decade vindicate major aspects of Woese’s vision. Despite the observations of pervasive horizontal gene transfer among bacteria and archaea, the ribosomal tree of life comes across as a central statistical trend in the “forest” of phylogenetic trees of individual genes, and hence, an appropriate scaffold for evolutionary reconstruction. The evolutionary stability of information processing systems, primarily translation, becomes ever more striking with the accumulation of comparative genomic data indicating that nearly allof the few universal genes encode translation system components. Woese’s view on the fundamental distinctions between the three domains of cellular life also withstand the test of comparative genomics, although his non-acceptance of symbiogenetic scenarios for the origin of eukaryotes might not. Above all, Woese’s key prediction that understanding evolution of microbes will be the core of the new evolutionary biology appears to be materializing. PMID:24572480

  5. Beyond synchronicity: the worldview of Carl Gustav Jung and Wolfgang Pauli.

    PubMed

    Donati, Marialuisa

    2004-11-01

    While exploring the phenomena of synchronicity, Carl Gustav Jung became acquainted with the quantum physicist Wolfgang Pauli and eventually began a collaboration with him. During that collaboration Jung's study of synchronistic phenomena underwent a considerable change; prior to the collaboration, Jung had stressed mainly the phenomenological and empirical features of synchronistic phenomena, while in association with Pauli, he focused his attention upon their ontological, archetypal character. Pauli, on the other hand, became increasingly sensitive to the philosophical aspects concerning the unconscious. Jung and Pauli's common reflections went far beyond psychology and physics, entering into the realm where the two areas meet in the philosophy of nature. In fact, as a consequence of their collaboration, synchronicity was transformed from an empirical concept into a fundamental explanatory-interpretative principle, which together with causality could possibly lead to a more complete worldview. Exploring the problematic character of the synchronicity concept has a heuristic value because it leads to the reconsideration of the philosophical issues that drove Jung and Pauli to clear up the conceptual background of their thoughts. Within the philosophical worldview arising from Jung and Pauli's discussions about synchronicity, there are many symbolic aspects that go against mainstream science and that represent a sort of criticism to some of the commonly held views of present day science.

  6. Taxonomic corrections to species of Rhyparochromidae (Hemiptera: Heteroptera) described by Carl Peter Thunberg.

    PubMed

    Kondorosy, Előd; Rédei, Dávid; Mejlon, Hans

    2014-07-22

    Types of Rhyparochromidae (Hemiptera: Heteroptera: Lygaeoidea) species described by Carl Peter Thunberg, deposited in the Museum of Evolution (formerly Zoologiska Institut), Uppsala University, Uppsala, Sweden, were reexamined and the taxonomic and nomenclatural problems that existed among those species discussed and resolved as required. Lectotypes are designated for Cimex caffer Thunberg, 1784, Lygaeus ater Thunberg, 1822, Lygaeus biguttatus Thunberg, 1822, and Pendulinus guttatus Thunberg, 1825. The lectotype of Pendulinus (now Metochus) guttatus is designated as neotype of Pendulinus (now Metochus) uniguttatus Thunberg, 1822; as a result the former name becomes junior objective synonym of the latter. The following taxonomic changes are proposed: Lethaeus ater (Thunberg, 1822), new combination (from Lygaeus); Migdilybs biguttatus (Thunberg, 1822), new combination (from Lygaeus) = Migdilybs furcifer Hesse, 1925, new subjective synonym; Metochus uniguttatus (Thunberg, 1822) = Metochus bengalensis (Dallas, 1852), confirmed subjective synonym = Metochus yeh (Dohrn, 1860), confirmed subjective synonym; Raglius alboacuminatus (Goeze, 1778) = Cimex caffer Thunberg, 1874, confirmed subjective synonym. Lethaeus barberi Slater, 1964 does not belong to Lethaeus Dallas, 1852 but currently it cannot be placed with confidence in any existing genus. 

  7. Carl Wilhelm Scheele, the discoverer of oxygen, and a very productive chemist.

    PubMed

    West, John B

    2014-12-01

    Carl Wilhelm Scheele (1742-1786) has an important place in the history of the discovery of respiratory gases because he was undoubtedly the first person to prepare oxygen and describe some of its properties. Despite this, his contributions have often been overshadowed by those of Joseph Priestley and Antoine Lavoisier, who also played critical roles in preparing the gas and understanding its nature. Sadly, Scheele was slow to publish his discovery and therefore Priestley is rightly recognized as the first person to report the preparation of oxygen. This being said, the thinking of both Scheele and Priestley was dominated by the phlogiston theory, and it was left to Lavoisier to elucidate the true nature of oxygen. In addition to his work on oxygen, Scheele was enormously productive in other areas of chemistry. Arguably he discovered seven new elements and many other compounds. However, he kept a low profile during his life as a pharmacist, and he did not have strong links with contemporary prestigious institutions such as the Royal Society in England or the French Académie des Sciences. He was elected to the Royal Swedish Academy of Science but only attended one meeting. Partly as a result, he remains a somewhat nebulous figure despite the critical contribution he made to the history of respiratory gases and his extensive researches in other areas of chemistry. His death at the age of 43 may have been hastened by his habit of tasting the chemicals that he worked on. PMID:25281638

  8. On the enduring and substantial influence of Carl Rogers' not-quite necessary nor sufficient conditions.

    PubMed

    Farber, Barry A

    2007-09-01

    Carl Rogers' 1957 paper (see record 2007-14639-002) is arguably the most successful of his many attempts to clarify and render testable the ideas behind client-centered therapy. While each of the conditions that Rogers postulated has been linked to positive therapeutic outcome, taken together they have never been conclusively proved (nor disproved) to be either necessary or sufficient for positive outcome. Nevertheless, the overriding "take-home" message in this classic paper--that the therapist's attitude and caring presence is critical for therapeutic success--is one that has had virtually unparalleled influence in every segment of the psychotherapeutic community. Clinical and theoretical innovations in the psychoanalytic community serve as examples of the following proposition: that Rogers' concepts, while accepted more than ever by a remarkably wide variety of psychotherapists, remain essentially unacknowledged as originating with him or in the tradition of humanistic and client-centered therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved). PMID:22122255

  9. Using Carl Rogers' person-centered model to explain interpersonal relationships at a school of nursing.

    PubMed

    Bryan, Venise D; Lindo, Jascinth; Anderson-Johnson, Pauline; Weaver, Steve

    2015-01-01

    Faculty members are viewed as nurturers within the academic setting and may be able to influence students' behaviors through the formation of positive interpersonal relationships. Faculty members' attributes that best facilitated positive interpersonal relationships according to Carl Rogers' Person-Centered Model was studied. Students (n = 192) enrolled in a 3-year undergraduate nursing program in urban Jamaica were randomly selected to participate in this descriptive cross-sectional study. A 38-item questionnaire on interpersonal relationships with nursing faculty and students' perceptions of their teachers was utilized to collect data. Factor analysis was used to create factors of realness, prizing, and empathetic understanding. Multiple linear regression analysis on the interaction of the 3 factors and interpersonal relationship scores was performed while controlling for nursing students' study year and age. One hundred sixty-five students (mean age: 23.18 ± 4.51years; 99% female) responded. The regression model explained over 46% of the variance. Realness (β = 0.50, P < .001) was the only significant predictor of the interpersonal relationship scores assigned by the nursing students. Of the total number of respondents, 99 students (60%) reported satisfaction with the interpersonal relationships shared with faculty. Nursing students' perception of faculty members' realness appeared to be the most significant attribute in fostering positive interpersonal relationships. PMID:25839954

  10. Carl Wilhelm Scheele, the discoverer of oxygen, and a very productive chemist.

    PubMed

    West, John B

    2014-12-01

    Carl Wilhelm Scheele (1742-1786) has an important place in the history of the discovery of respiratory gases because he was undoubtedly the first person to prepare oxygen and describe some of its properties. Despite this, his contributions have often been overshadowed by those of Joseph Priestley and Antoine Lavoisier, who also played critical roles in preparing the gas and understanding its nature. Sadly, Scheele was slow to publish his discovery and therefore Priestley is rightly recognized as the first person to report the preparation of oxygen. This being said, the thinking of both Scheele and Priestley was dominated by the phlogiston theory, and it was left to Lavoisier to elucidate the true nature of oxygen. In addition to his work on oxygen, Scheele was enormously productive in other areas of chemistry. Arguably he discovered seven new elements and many other compounds. However, he kept a low profile during his life as a pharmacist, and he did not have strong links with contemporary prestigious institutions such as the Royal Society in England or the French Académie des Sciences. He was elected to the Royal Swedish Academy of Science but only attended one meeting. Partly as a result, he remains a somewhat nebulous figure despite the critical contribution he made to the history of respiratory gases and his extensive researches in other areas of chemistry. His death at the age of 43 may have been hastened by his habit of tasting the chemicals that he worked on.

  11. The British Interplanetary Society - Val Cleaver and Wernher von Braun

    NASA Astrophysics Data System (ADS)

    Willhite, I. P.

    This article is concerned with the early relationship between Wernher von Braun and the British Interplanetary Society (BIS). The BIS/Wernher von Braun/Val Cleaver correspondence files located here at the US Space & Rocket Center in Huntsville, Alabama are unparalleled. As one reads the stimulating comments between Cleaver and von Braun, the need to share their thoughts prevails. Following is an excerpt from one letter that whets ones appetite for more. 10 June 1951 Cleaver writes, “I'm so glad you enjoyed my last letter, and look forward to your promised further contribution to our discussion of the ethics of science in general and astronautics in particu- lar. As regards the one particular point on which you found yourself unable to hold your fire, I should say there are really two distinct issues at stake:. . .” This article attempts to represent the best of the letters as they goad each other on scientific principles, means to prevent wars, and other philosophic ideas.

  12. [Von Hippel-Lindau syndrome].

    PubMed

    Reich, H; Hollwich, F

    1984-06-01

    The von Hippel-Lindau syndrome is an autosomal dominant condition that comprises, apart from angiomas of the retina, the cerebellum, the spinal cord, and the cerebrum, also cystic and blastomatous dysplasias resulting from maldevelopment, namely cystic kidney and pancreas, hypernephroma, and pheochromocytoma. Early observers of the syndrome were the English neurologist John Hughlings Jackson (1872) and the German ophthalmologist Hugo Magnus (1874). The typical association of angiomas of the retina with the cerebellum was first described in 1905 by the Prague ophthalmologist Wilhelm Czermak, long before Lindau (1926). The fact that hypernephromas and pheochromocytomas may form parts of it characterizes the syndrome as a polyneoplastic hereditary disease and the sufferers as members of families at risk. Since the ophthalmologist is often the first to recognize this disease by direct inspection of the fundi, he is responsible for ensuring proper medical care for the affected person and his or her entire family.

  13. Renaturierung und Management von Heiden

    NASA Astrophysics Data System (ADS)

    Härdtle, Werner; Assmann, Thorsten; van Diggelen, Rudy; von Oheimb, Goddert

    Heiden zählen zu den ältesten und besonders reizvollen Kulturlandschaften Nordwesteuropas. Sie sind bezeichnend für nährstoffarme Böden in wintermilden Gebieten mit hohen Sommerniederschlägen. Während Heiden vor wenigen Jahrhunderten noch weit verbreitet und für manche Landschaften sogar prägend waren, hat sich ihr Areal heute auf wenige, meist in Naturschutzgebieten gelegene Restbestände verkleinert. Zu diesem Rückgang haben maßgeblich Änderungen der Landnutzung, aber auch Nährstoffeinträge aus umgebenden Agrarflächen und atmogene Depositionen beigetragen. In den meisten Ländern der Europäischen Union sind Heiden heute gesetzlich geschützte Ökosysteme, da diese, neben ihrem Erholungswert für den Menschen, Pflanzen- und Tierarten beherbergen, die außerhalb von Heiden nicht oder kaum überlebensfähig sind.

  14. Richard von Volkmann: surgeon and Renaissance man.

    PubMed

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R; Mubarak, Scott J

    2008-02-01

    Richard von Volkmann (1830-1889), one of the most important surgeons of the 19(th) century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867-1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the "antiseptic technique" to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann's contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children's fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics.

  15. Richard von Volkmann: surgeon and Renaissance man.

    PubMed

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R; Mubarak, Scott J

    2008-02-01

    Richard von Volkmann (1830-1889), one of the most important surgeons of the 19(th) century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867-1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the "antiseptic technique" to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann's contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children's fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics. PMID:18196438

  16. Wally Schirra Greets Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Apollo 7 Commander Walter M. Schirra, Jr., left, greets Dr. Wernher Von Braun, Director, Marshall Space Flight Center and Dr. Kurt Debus, Right, KSC Director, during a prelaunch mission briefing held at the Florida Spaceport.

  17. Von Hippel-Lindau Disease (VHL)

    MedlinePlus

    ... Funding Information Research Programs Training & Career Awards Enhancing Diversity Find People About NINDS NINDS Von Hippel-Lindau ... News From NINDS | Find People | Training | Research | Enhancing Diversity Careers@NINDS | FOIA | Accessibility Policy | Contact Us | Privacy ...

  18. [Carl Gillmeister: the first Doctor of veterinary medicine in Mecklenburg--and in Germany (1834)].

    PubMed

    Kuhlmann, W; Schäffer, J

    2004-02-01

    German schools and faculties of veterinary medicine did not receive the sovereign right to award the degree "Doctor medicinae veterinarae" until the early twentieth century. Until then, in the nineteenth century there were two possibilities for veterinarians to earn a doctoral degree, usually referred to as the title of "Doctor": 1. On the basis of an exceptionally excellent dissertation and after very stringent examination a candidate could be awarded the degree "Dr. med." by the faculty of a medical school, or, if the candidate had studied at a philosophical faculty, the degree "Dr. phil." 2. A doctoral degree specifically in veterinary medicine could be earned only at a medical faculty. The Medical Faculty of the University of Giessen awarded the degree "Doctor in arte veterinaria" for the first time in 1832. In this study we prove that Giessen was not the first German university to award a doctorate in veterinary medicine, a priority which has never been questioned in the literature. As early as 1829, veterinarians could earn the degree "Doctor artis veterinariae" at the Medical Faculty of the University of Rostock, where three such awards are documented between 1829 and 1831. The designation "medicina" was also intially avoided in Rostock. Therefore, of particular significance is the discovery of a fourth such document from the Rostock University Archives, the doctoral diploma of Carl Jacob Friedrich Gillmeister, who at the age of 22 was awarded the degree "Doctor medicinae veterinariae" in Rostock after a successful defense. This is the earliest, but also the last archival record of the German doctoral degree in veterinary medicine in the modern sense, because after Gillmeister no veterinarian could earn a doctoral degree in Rostock further more. Gillmeisters vita sheds light on the times and the difficulties of the veterinary profession in the poor agricultural area of Mecklenburg. PMID:15032266

  19. [Carl Gillmeister: the first Doctor of veterinary medicine in Mecklenburg--and in Germany (1834)].

    PubMed

    Kuhlmann, W; Schäffer, J

    2004-02-01

    German schools and faculties of veterinary medicine did not receive the sovereign right to award the degree "Doctor medicinae veterinarae" until the early twentieth century. Until then, in the nineteenth century there were two possibilities for veterinarians to earn a doctoral degree, usually referred to as the title of "Doctor": 1. On the basis of an exceptionally excellent dissertation and after very stringent examination a candidate could be awarded the degree "Dr. med." by the faculty of a medical school, or, if the candidate had studied at a philosophical faculty, the degree "Dr. phil." 2. A doctoral degree specifically in veterinary medicine could be earned only at a medical faculty. The Medical Faculty of the University of Giessen awarded the degree "Doctor in arte veterinaria" for the first time in 1832. In this study we prove that Giessen was not the first German university to award a doctorate in veterinary medicine, a priority which has never been questioned in the literature. As early as 1829, veterinarians could earn the degree "Doctor artis veterinariae" at the Medical Faculty of the University of Rostock, where three such awards are documented between 1829 and 1831. The designation "medicina" was also intially avoided in Rostock. Therefore, of particular significance is the discovery of a fourth such document from the Rostock University Archives, the doctoral diploma of Carl Jacob Friedrich Gillmeister, who at the age of 22 was awarded the degree "Doctor medicinae veterinariae" in Rostock after a successful defense. This is the earliest, but also the last archival record of the German doctoral degree in veterinary medicine in the modern sense, because after Gillmeister no veterinarian could earn a doctoral degree in Rostock further more. Gillmeisters vita sheds light on the times and the difficulties of the veterinary profession in the poor agricultural area of Mecklenburg.

  20. Dr. von Braun With German Rocket Experimenters

    NASA Technical Reports Server (NTRS)

    1930-01-01

    Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

  1. Renaturierung von Tagebaufolgeflächen

    NASA Astrophysics Data System (ADS)

    Tischew, Sabine

    Der Abbau von Rohstoffen im Tagebauverfahren bedingt einen tief greifenden Landschafts- und Strukturwandel in den betroffenen Regionen. In der Abbauphase hat vor allem der Braunkohleabbau mit den tagebauübergreifenden Grundwasserabsenkungstrichtern, der Zerstörung oder Beeinträchtigung von ausgedehnten naturnahen Auenökosystemen sowie Wäldern und Elementen der Kulturlandschaft aus der Sicht des Naturschutzes überwiegend negative landschaftsökologische Folgen. Vor allem der Eingriff in Ökosysteme mit langen Entwicklungszeiten (alte Wälder, Moore) oder in die Dynamik von Auensystemen ist nicht oder nur in sehr langen Zeiträumen wieder ausgleichbar. Für letztere ist auch langfristig die Durchgängigkeit für viele Tierarten (Arten der Fließgewässer) nicht wieder vollständig herstellbar. Oft ist es zudem schwierig, traditionelle Landnutzungen (z. B. Wanderschäferei, Nutzung von Streuobstwiesen) nach der langen Abbauphase wieder aufzugreifen. Es ist deshalb eine wichtige Aufgabe, nach dem Abbauprozess auf der Grundlage der vorhandenen Potenziale eine nachhaltige Entwicklung der Bergbaufolgelandschaft zu unterstützen und von den Betreibern des Abbaus und von den Sanierungsgesellschaften auch einzufordern (z. B. Bauer 1998).

  2. [Sigmund Freud, Rudolf Meringer and Carl Mayer: slips of the tongue and mis-readings. The history of a controversy].

    PubMed

    Hinterhuber, Hartmann

    2007-01-01

    In both his The Psychopathology of Everyday Life and his Lectures Sigmund Freud derived the terms unconscious, preconscious and conscious, particularly from slips in speech, slips in reading and forgetfulness. In these slips, Freud recognised parallels to dreams. In the work mentioned, he analysed these in depth as part of mental motivation. In the papers referred to, Sigmund Freud paid tribute to Rudolf Meringer and Carl Mayer's study which was published in 1895. Meringer and Mayer showed as phenomena reversals and rearrangement of whole words, syllables or sounds, along with pre-tones or anticipations and echoes, word contaminations and word substitutions as responsible for slips of the tongue. The present work demonstrates how passionately these three scientists have contributed to the controversy of their standpoints. For modern psycholinguistics and the psychology of language, speech errors are always an expression of a momentary malfunction of the human speech production system: for the cognitive process of speech production slips of the tongue offer an insight into speech processing. Pre-tones and echoes, serialization errors, as Meringer and Mayer recognised, represent the vast majority of slips of the tongue. They do not reveal any hidden point. But with lexical-semantic slips of the tongue the question of mental motivation is admissible. This short paper is a sign of appreciation and gratitude: firstly, a modest birthday gift for Sigmund Freud, secondly homage to Carl Mayer, who influenced generations of neurologists in his 40 years of chairing the Psychiatric-Neurological Clinic in Innsbruck, so that Hans Ganner rightly spoke of a "Carl Mayer School". But lastly, this short study is also-and especially-a late recognition of Rudolf Meringer, the great Austrian linguist. The view an individual has concerning mental processes and the "topology of the psychic apparatus" is decisive as to the power of determination attached to the unconscious.

  3. Otto Rank, the Rankian circle in Philadelphia, and the origins of Carl Rogers' person-centered psychotherapy.

    PubMed

    deCarvalho, R J

    1999-05-01

    Otto Rank's will therapy helped shape the ideas and techniques of relationship therapy developed by the Philadelphia social workers Jessie Taft, Virginia Robinson, and Frederick Allen in the 1930s. Rank's work and these ideas and techniques in turn strongly influenced the formulation of Carl Rogers' person-centered psychotherapy. This article compares and contrasts will, relationship, and person-centered approaches to psychotherapy and discusses the social factors--primarily the professional conflicts between a male-dominated psychiatry and female social workers over the independent practice of psychotherapy--that were crucial in the dissemination of Rank's psychological thought and the early popularity of Rogers.

  4. "The most important technique …": Carl Rogers, Hawthorne, and the rise and fall of nondirective interviewing in sociology.

    PubMed

    Lee, Raymond M

    2011-01-01

    In the 1940s, interviewing practice in sociology became decisively influenced by techniques that had originally been developed by researchers in other disciplines working within a number of therapeutic or quasi-therapeutic contexts, in particular the "nondirective interviewing" methods developed by Carl Rogers and the interviewing procedures developed during the Hawthorne studies. This article discusses the development of nondirective interviewing and looks at how in the 1930s and '40s the approach came to be used in sociology. It examines the factors leading to both the popularity of the method and its subsequent fall from favor. PMID:21462193

  5. Otto Rank, the Rankian circle in Philadelphia, and the origins of Carl Rogers' person-centered psychotherapy.

    PubMed

    deCarvalho, R J

    1999-05-01

    Otto Rank's will therapy helped shape the ideas and techniques of relationship therapy developed by the Philadelphia social workers Jessie Taft, Virginia Robinson, and Frederick Allen in the 1930s. Rank's work and these ideas and techniques in turn strongly influenced the formulation of Carl Rogers' person-centered psychotherapy. This article compares and contrasts will, relationship, and person-centered approaches to psychotherapy and discusses the social factors--primarily the professional conflicts between a male-dominated psychiatry and female social workers over the independent practice of psychotherapy--that were crucial in the dissemination of Rank's psychological thought and the early popularity of Rogers. PMID:11623737

  6. "The most important technique …": Carl Rogers, Hawthorne, and the rise and fall of nondirective interviewing in sociology.

    PubMed

    Lee, Raymond M

    2011-01-01

    In the 1940s, interviewing practice in sociology became decisively influenced by techniques that had originally been developed by researchers in other disciplines working within a number of therapeutic or quasi-therapeutic contexts, in particular the "nondirective interviewing" methods developed by Carl Rogers and the interviewing procedures developed during the Hawthorne studies. This article discusses the development of nondirective interviewing and looks at how in the 1930s and '40s the approach came to be used in sociology. It examines the factors leading to both the popularity of the method and its subsequent fall from favor.

  7. The von Neumann model of measurement in quantum mechanics

    SciTech Connect

    Mello, Pier A.

    2014-01-08

    We describe how to obtain information on a quantum-mechanical system by coupling it to a probe and detecting some property of the latter, using a model introduced by von Neumann, which describes the interaction of the system proper with the probe in a dynamical way. We first discuss single measurements, where the system proper is coupled to one probe with arbitrary coupling strength. The goal is to obtain information on the system detecting the probe position. We find the reduced density operator of the system, and show how Lüders rule emerges as the limiting case of strong coupling. The von Neumann model is then generalized to two probes that interact successively with the system proper. Now we find information on the system by detecting the position-position and momentum-position correlations of the two probes. The so-called 'Wigner's formula' emerges in the strong-coupling limit, while 'Kirkwood's quasi-probability distribution' is found as the weak-coupling limit of the above formalism. We show that successive measurements can be used to develop a state-reconstruction scheme. Finally, we find a generalized transform of the state and the observables based on the notion of successive measurements.

  8. von Braun 1952 Space Station Concept

    NASA Technical Reports Server (NTRS)

    1952-01-01

    This is a von Braun 1952 space station concept. In a 1952 series of articles written in Collier's, Dr. Wernher von Braun, then Technical Director of the Army Ordnance Guided Missiles Development Group at Redstone Arsenal, wrote of a large wheel-like space station in a 1,075-mile orbit. This station, made of flexible nylon, would be carried into space by a fully reusable three-stage launch vehicle. Once in space, the station's collapsible nylon body would be inflated much like an automobile tire. The 250-foot-wide wheel would rotate to provide artificial gravity, an important consideration at the time because little was known about the effects of prolonged zero-gravity on humans. Von Braun's wheel was slated for a number of important missions: a way station for space exploration, a meteorological observatory and a navigation aid. This concept was illustrated by artist Chesley Bonestell.

  9. Dr. Wernher Von Braun talkes with George Hardy.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    George Hardy of the Marshall Space Flight center's Astronautics Laboratory, talks with Dr. Wernher Von Braun (right), deputy associate administrator for planning. Dr. Von Braun was inspecting the mockup of the Saturn workshop during a visit to the Marshall Center. The visit coincided with the 10th anniversary celebration of the center of which Dr. Von Braun was director until March 1, 1970.

  10. Bewertung von Fahrzeuggeräuschen

    NASA Astrophysics Data System (ADS)

    Genuit, Klaus; Schulte-Fortkamp, Brigitte; Fiebig, André; Haverkamp, Michael

    Bei der Wahrnehmung und Beurteilung eines Automobils sind unzählige Merkmale und Eigenschaften von Bedeutung. Dabei können Merkmale objektiv-technisch beschrieben werden, wie Angaben zur Motorisierung, Höchstgeschwindigkeit, Drehmoment, zulässige Zuladung, Verbrauch usw. Daneben sind weitere Eigenschaften von Bedeutung, die sich einer einfachen objektiv-technischen Beschreibung entziehen. Hier sind Begriffe zu nennen, wie Sicherheit, allgemeine Qualitätsanmutung, Design, Ergonomie, Komfort, Haptik, Fahrdynamik, Zuverlässigkeit, die deutlich schwieriger objektiv erfassbar und beschreibbar sind (Abb. 4.1).

  11. Chest wall angiolipoma complicating von Recklinghausen disease.

    PubMed

    Komatsu, Teruya; Takahashi, Koji; Fujinaga, Takuji

    2013-09-01

    We present the case of an 18-year-old man with chest wall angiolipoma and a medical history of von Recklinghausen neurofibromatosis. The chest wall tumor was originally detected during an evaluation for chest pain. For diagnostic and therapeutic purposes, video-assisted thoracoscopic resection was performed, and the tumor was histopathologically confirmed to be an angiolipoma. Chest wall angiolipoma is exceptionally rare. Only two cases have been reported in the English literature, with no reports regarding chest wall angiolipoma in a patient with von Recklinghausen disease.

  12. Carl D. Perkins Vocational and Technical Education Act of 1998. Report to Congress on State Performance, Program Year 2005-06

    ERIC Educational Resources Information Center

    Office of Vocational and Adult Education, US Department of Education, 2008

    2008-01-01

    The "Carl D. Perkins Vocational and Technical Education Act of 1998" (commonly referred to as "Perkins," "Perkins III," or "the Act" and referred to hereafter as Perkins III) requires, in Sec. 113(c)(3)(C), that the secretary provide the appropriate committees of Congress copies of annual reports received by the U.S. Department of Education…

  13. (Never) Mind your p's and q's: Von Neumann versus Jordan on the foundations of quantum theory

    NASA Astrophysics Data System (ADS)

    Duncan, A.; Janssen, M.

    2013-03-01

    In 1927, in two papers entitled "On a new foundation [Neue Begründung] of quantum mechanics," Pascual Jordan presented his version of what came to be known as the Dirac-Jordan statistical transformation theory. Jordan and Paul Dirac arrived at essentially the same theory independently of one another at around the same time. Later in 1927, partly in response to Jordan and Dirac and avoiding the mathematical difficulties facing their approach, John von Neumann developed the modern Hilbert space formalism of quantum mechanics. We focus on Jordan and von Neumann. Central to the formalisms of both are expressions for conditional probabilities of finding some value for one quantity given the value of another. Beyond that Jordan and von Neumann had very different views about the appropriate formulation of problems in quantum mechanics. For Jordan, unable to let go of the analogy to classical mechanics, the solution of such problems required the identification of sets of canonically conjugate variables, i.e., p's and q's. For von Neumann, not constrained by the analogy to classical mechanics, it required only the identification of a maximal set of commuting operators with simultaneous eigenstates. He had no need for p's and q's. Jordan and von Neumann also stated the characteristic new rules for probabilities in quantum mechanics somewhat differently. Jordan and Dirac were the first to state those rules in full generality. Von Neumann rephrased them and, in a paper published a few months later, sought to derive them from more basic considerations. In this paper we reconstruct the central arguments of these 1927 papers by Jordan and von Neumann and of a paper on Jordan's approach by Hilbert, von Neumann, and Nordheim. We highlight those elements in these papers that bring out the gradual loosening of the ties between the new quantum formalism and classical mechanics. This paper was written as part of a joint project in the history of quantum physics of the Max Planck

  14. Alexander von Humboldt: a revolutionary explorer.

    PubMed

    Fara, Patricia

    2008-03-01

    After he returned from his five-year expedition to the New World, Alexander von Humboldt promoted himself as a Romantic explorer. Although this image pervades British perceptions, political movements have fashioned different heroic versions of Humboldt in Germany and South America.

  15. Dr. von Braun Visits Huntsville Boys Club

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

  16. Dr. von Braun Discusses 'Bottle Suit' Concept

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a 'bottle suit' model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled 'Man in Space.'

  17. Von Gierke's disease: report of case.

    PubMed

    Cudzinowski, L

    1979-01-01

    Von Gierke's disease, or hepatorenal glycogenesis, type I, presents an interesting challenge to the dental practitioner. Showing an incidence of 1/400,000, it is a fairly rare occurrence. It indicates the importance of proper medical consultation in treating these children, and proper dental treatment and preventive programs to alleviate what could be dangerous for these patients. PMID:289662

  18. Herstellung von Chitosan und einige Anwendungen

    NASA Astrophysics Data System (ADS)

    Struszczyk, Marcin Henryk

    2001-05-01

    1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

  19. A note on derivations of Murray–von Neumann algebras

    PubMed Central

    Kadison, Richard V.; Liu, Zhe

    2014-01-01

    A Murray–von Neumann algebra is the algebra of operators affiliated with a finite von Neumann algebra. In this article, we first present a brief introduction to the theory of derivations of operator algebras from both the physical and mathematical points of view. We then describe our recent work on derivations of Murray–von Neumann algebras. We show that the “extended derivations” of a Murray–von Neumann algebra, those that map the associated finite von Neumann algebra into itself, are inner. In particular, we prove that the only derivation that maps a Murray–von Neumann algebra associated with a factor of type II1 into that factor is 0. Those results are extensions of Singer’s seminal result answering a question of Kaplansky, as applied to von Neumann algebras: The algebra may be noncommutative and may even contain unbounded elements. PMID:24469831

  20. Testing aspects of Carl Rogers's theory of creative environments: child-rearing antecedents of creative potential in young adolescents.

    PubMed

    Harrington, D M; Block, J H; Block, J

    1987-04-01

    Longitudinal data involving 106 children and their parents were used to test preschool child-rearing implications of Carl Rogers's theory of creativity-fostering environments (Rogers, 1954). Indices were developed for each parent and for each mother-father combination that reflected the degree to which the parents' child-rearing practices and interactions with their preschool children matched the recommendations implicit in Rogers's description of a creativity-fostering environment. The three indices of Rogers-prescribed child-rearing practices each correlated positively (rs = .38 to .46) and significantly (all ps less than .001) with a composite index of creative potential in early adolescence, 7 to 11 years later. Rogers-prescribed preschool child-rearing practices also emerged as significant antecedents of adolescent creative potential in regression/path analyses that held constant the influence of sex, preschool intelligence, and preschool creative potential. Theoretical and methodological aspects of the study are discussed.

  1. Testing aspects of Carl Rogers's theory of creative environments: child-rearing antecedents of creative potential in young adolescents.

    PubMed

    Harrington, D M; Block, J H; Block, J

    1987-04-01

    Longitudinal data involving 106 children and their parents were used to test preschool child-rearing implications of Carl Rogers's theory of creativity-fostering environments (Rogers, 1954). Indices were developed for each parent and for each mother-father combination that reflected the degree to which the parents' child-rearing practices and interactions with their preschool children matched the recommendations implicit in Rogers's description of a creativity-fostering environment. The three indices of Rogers-prescribed child-rearing practices each correlated positively (rs = .38 to .46) and significantly (all ps less than .001) with a composite index of creative potential in early adolescence, 7 to 11 years later. Rogers-prescribed preschool child-rearing practices also emerged as significant antecedents of adolescent creative potential in regression/path analyses that held constant the influence of sex, preschool intelligence, and preschool creative potential. Theoretical and methodological aspects of the study are discussed. PMID:3572740

  2. Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions

    NASA Astrophysics Data System (ADS)

    Cheng, Szu-Cheng; Jheng, Shih-Da

    2016-08-01

    This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions.

  3. Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions

    PubMed Central

    Cheng, Szu-Cheng; Jheng, Shih-Da

    2016-01-01

    This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions. PMID:27545446

  4. The signalling contributions of Constantin von Economo to basic, clinical and evolutionary neuroscience.

    PubMed

    Triarhou, Lazaros C

    2006-04-14

    The study, and the companion article that follows, reviews the entire spectrum of the epoch-making contributions of Constantin von Economo (1876-1931) to basic, clinical and evolutionary Neuroscience. An astute observer and avid writer, von Economo left marks of brilliance on fundamental areas of brain research through an exuberant record of publications dating from 1899 to 1932. His ingenious medical career began with the histological study of the developing pigeon and chick hypophysis, and culminated with bold propositions about the neuroanatomy of talent and the future evolution of the human brain. On the way, he made the seminal discovery of encephalitis lethargica ('von Economo disease'), and produced, with Georg N. Koskinas (1885-1975), one of the masterpieces of brain science, the 1925 Cytoarchitectonics of the Adult Human Cerebral Cortex, defining 107 cortical areas on the basis of cytoarchitectonic criteria. His untimely death at age 55, barely 5.5 months after inaugurating his new Brain Research Institute in Vienna, deprived the Neuroscience world of one of its brightest protagonists during the 20th century. An annotated total of 139 scientific works by von Economo have been identified. The present study covers the 76 works on brain structure, evolution and intelligence, and general works on nervous and mental pathology, with the complete bibliographic information. The companion article covers the remaining 63 works on encephalitis lethargica and sleep regulation.

  5. Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions.

    PubMed

    Cheng, Szu-Cheng; Jheng, Shih-Da

    2016-01-01

    This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions. PMID:27545446

  6. Inattentional blindness and the von Restorff effect.

    PubMed

    Schmidt, Stephen R; Schmidt, Constance R

    2015-02-01

    Sometimes we fail to notice distinctive or unusual items (inattentional blindness), while other times we remember distinctive items more than expected items (the von Restorff effect). A three-factor framework is presented and tested in two experiments in an attempt to reconcile these seemingly contradictory phenomena. Memory for different types of unexpected stimuli was tested after an easy or difficult Stroop color-naming task. Highly arousing taboo words were well remembered even when the difficult Stroop task limited attentional resources. However, a conceptual isolation effect was only observed when the nature of the category change was highlighted by the Stroop task, the Stroop task was easy, and/or the isolated targets enjoyed a retrieval advantage relative to comparison targets. As proposed in the three-factor framework, the arousing qualities of the stimuli, the attentional demands of the primary task, and the relevance of isolated features at encoding and retrieval combine to produce inattentional blindness and the von Restorff effect.

  7. Epithelial cells and Von Gierke's disease.

    PubMed

    Negishi, H; Benke, P J

    1977-08-01

    Epithelial cells and not fibroblasts from human liver and amniotic fluid contain inducible glucose-6-phosphatase (G-6-Pase) activity. The diagnosis of Von Gierke's disease has been made in a patient with hepatomegaly utilizing cultured epithelial cells grown from a liver biopsy. G-6-Pase activity in epithelial cells from this patient could not be induced by dibutyryl cyclic AMP and theophylline. This is the first use of epithelial cells for diagnosis of a metabolic disease. G-6-Pase activity in cloned epithelial cells from amniotic fluid increases 2- to 3-fold after 24-hr exposure to dibutyryl cyclic AMP and theophylline. The prenatal diagnosis of Von Gierke's disease may be possible in a laboratory experienced with these techniques if epithelial cell growth is obtained from amniotic fluid. PMID:196249

  8. The von Nardroff Color Mixing Apparatus

    NASA Astrophysics Data System (ADS)

    Greenslade, Thomas B.

    2005-12-01

    Ernest von Nardroff gave his name to the color mixing apparatus shown in Fig. 1. The basic idea behind this demonstration is to produce three beams of colored light that may be projected onto a white surface. If beams of red, blue, and green are overlapped to produce a figure like a three leaf clover or a Venn diagram, the region of complete overlap will appear white, and the three regions of overlap of two colors produce the three false primaries: yellow, magenta, and cyan. A straightforward technique is to use three slide projectors, each with a colored filter. Von Nardroff's apparatus, displayed at the educational exhibit of Erasmus Hall High School at the Louisiana Purchase Exposition in St. Louis in 1904, permits the use of only one projector.

  9. Herstellung von Chitosan und einige Anwendungen

    NASA Astrophysics Data System (ADS)

    Struszczyk, Marcin Henryk

    2001-05-01

    1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

  10. Portrait of Dr. Von Braun with Walt Disney, 1954.

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  11. [The history of the prosector's department of the Charité Berlin. 3. Rudolf Ludwig Carl Virchow, prosector of Charité, 1846 to 1849].

    PubMed

    Krietsch, P

    1991-01-01

    Rudolf Ludwig Carl Virchow (1821-1902) had been prosector at the Charité of Berlin, from 1846 to 1849. He had moved to Berlin in October 1839 for army surgeon training at the Pépinière, the Academy of Military Medicine. He had to choose that line of education, as it was free, for his parents were in no financial position to pay for ordinary university studies. On completion of theoretical classes, Easter 1843, he was delegated to Charité for an 18-months practical training programme. He worked in all compulsory clinical departments and, subsequently, took up service in the Prosector's Department then headed by Robert F. Froriep who guided and supported Virchow towards independent scientific activity. Virchow defended his doctoral thesis with good success in 1843. His application for the expected vacant office of Prosector was supported by Froriep before he left Berlin in 1846. The application was granted "ad interim", on May 11, 1846. His name became known very soon on account of his ambitious commitment. He also began to take a growing commitment to political change in Prussia in general, and change to the medical system in particular. He achieved discharge from military service in 1847, formally qualified for university lecturing, and was officially appointed as Prosector and lecturer. In the same year, 1847, he founded the "Archives" in cooperation with Benno H. E. Reinhardt. During an epidemic cholera outbreak in Berlin and an outbreak of petechial typhus in Upper Silesia, early 1848, he realised social root causes of disease and accused the Prussian government for negligence of its own citizens. He then joined the March struggles of 1848 out of his insight into the need for change of society. A weekly under the heading of "Die medicinische Reform" ("Reform in Medicine") was published under Virchow's editorship, from mid-1848 to mid-1849. Early 1849, his involvement on the premises of Charité in a leaflet campaign against planned mock elections in Prussia

  12. Carl gustav jung, quantum physics and the spiritual mind: a mystical vision of the twenty-first century.

    PubMed

    Valadas Ponte, Diogo; Schäfer, Lothar

    2013-12-01

    We describe similarities in the ontology of quantum physics and of Carl Gustav Jung's psychology. In spite of the fact that physics and psychology are usually considered as unrelated, in the last century, both of these disciplines have led at the same time to revolutionary changes in the Western understanding of the cosmic order, discovering a non-empirical realm of the universe that doesn't consist of material things but of forms. These forms are real, even though they are invisible, because they have the potential to appear in the empirical world and act in it. We present arguments that force us to believe, that the empirical world is an emanation out of a cosmic realm of potentiality, whose forms can appear as physical structures in the external world and as archetypal concepts in our mind. Accordingly, the evolution of life now appears no longer as a process of the adaptation of species to their environment, but as the adaptation of minds to increasingly complex forms that exist in the cosmic potentiality. The cosmic connection means that the human mind is a mystical mind.

  13. Carl gustav jung, quantum physics and the spiritual mind: a mystical vision of the twenty-first century.

    PubMed

    Valadas Ponte, Diogo; Schäfer, Lothar

    2013-12-01

    We describe similarities in the ontology of quantum physics and of Carl Gustav Jung's psychology. In spite of the fact that physics and psychology are usually considered as unrelated, in the last century, both of these disciplines have led at the same time to revolutionary changes in the Western understanding of the cosmic order, discovering a non-empirical realm of the universe that doesn't consist of material things but of forms. These forms are real, even though they are invisible, because they have the potential to appear in the empirical world and act in it. We present arguments that force us to believe, that the empirical world is an emanation out of a cosmic realm of potentiality, whose forms can appear as physical structures in the external world and as archetypal concepts in our mind. Accordingly, the evolution of life now appears no longer as a process of the adaptation of species to their environment, but as the adaptation of minds to increasingly complex forms that exist in the cosmic potentiality. The cosmic connection means that the human mind is a mystical mind. PMID:25379259

  14. Carl Gustav Jung, Quantum Physics and the Spiritual Mind: A Mystical Vision of the Twenty-First Century

    PubMed Central

    Valadas Ponte, Diogo; Schäfer, Lothar

    2013-01-01

    We describe similarities in the ontology of quantum physics and of Carl Gustav Jung’s psychology. In spite of the fact that physics and psychology are usually considered as unrelated, in the last century, both of these disciplines have led at the same time to revolutionary changes in the Western understanding of the cosmic order, discovering a non-empirical realm of the universe that doesn’t consist of material things but of forms. These forms are real, even though they are invisible, because they have the potential to appear in the empirical world and act in it. We present arguments that force us to believe, that the empirical world is an emanation out of a cosmic realm of potentiality, whose forms can appear as physical structures in the external world and as archetypal concepts in our mind. Accordingly, the evolution of life now appears no longer as a process of the adaptation of species to their environment, but as the adaptation of minds to increasingly complex forms that exist in the cosmic potentiality. The cosmic connection means that the human mind is a mystical mind. PMID:25379259

  15. Victor or Villain? Wernher von Braun and the Space Race

    ERIC Educational Resources Information Center

    O'Brien, Jason L.; Sears, Christine E.

    2011-01-01

    Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

  16. DEBUS, KURT H. AND WERNHER VON BRAUN IN SATURN BLOCKHOUSE

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Cape Kennedy - Dr. Wernher von Braun, director of the National Aeronautics and Space Administration's Marshall Space Flight Center, points to a television screen in the Saturn blockhouse. The screen showed Saturn I vehicle, carrying Pegasus satellite into orbit, during launch. Dr. Kurt Debus, director of NASA's Kennedy Space Center, is seated at Dr. von Braun's right.

  17. Asymptotic behavior to a von Kármán equations of memory type with acoustic boundary conditions

    NASA Astrophysics Data System (ADS)

    Kang, Jum-Ran

    2016-06-01

    We study the stability of solutions to a von Kármán plate model of memory type with acoustic boundary conditions. We establish the general decay rate result, using some properties of the convex functions. Our result is obtained without imposing any restrictive assumptions on the behavior of the relaxation function at infinity. These general decay estimates extend and improve on some earlier results-exponential or polynomial decay rates.

  18. Key contributors: Ernst von Glasersfeld's radical constructivism

    NASA Astrophysics Data System (ADS)

    Tobin, Kenneth

    2007-07-01

    This article reviews the significance of the contributions of Ernst von Glasersfeld to research in science education, especially through his theoretical contributions on radical constructivism. As a field shaper, Glasersfeld's subversive ideas catalyzed debate in the science education community and fuelled transformation of many facets including research methods, ways of thinking about teaching and learning, curriculum, and science teacher education. Perturbations emanating from the debates on constructivism forged new pathways that led to the development and use of many of the sociocultural frameworks employed by authors in Cultural Studies of Science Education.

  19. Approximating incompatible von Neumann measurements simultaneously

    SciTech Connect

    Heinosaari, Teiko; Jivulescu, Maria Anastasia; Reitzner, Daniel; Ziman, Mario

    2010-09-15

    We study the problem of performing orthogonal qubit measurements simultaneously. Since these measurements are incompatible, one has to accept additional imprecision. An optimal joint measurement is the one with the least possible imprecision. All earlier considerations of this problem have concerned only joint measurability of observables, while in this work we also take into account conditional state transformations (i.e., instruments). We characterize the optimal joint instrument for two orthogonal von Neumann instruments as being the Lueders instrument of the optimal joint observable.

  20. Renaturierung von Waldökosystemen

    NASA Astrophysics Data System (ADS)

    Zerbe, Stefan

    Wälder sind neben der Landwirtschaft und den urban-industriellen Siedlungsflächen flächenmäßig die Hauptnutzungstypen in Mitteleuropa und stellen heute multifunktionale ökosysteme dar. Zusätzlich zur Holzproduktion kommt ihnen eine Regulations-(z.B.Wasserhaushalt), Schutz (z.B. von Biodiversität und gegen Erosion, Lawinen, Immissionen und Lärm) und Erholungsfunktion zu. Zudem haben Wälder als Kohlenstoffsenken auch eine besondere Bedeutung für den Klimaschutz.

  1. Edge-Flames in Von Karman Swirling Flows

    NASA Technical Reports Server (NTRS)

    Nayagam, Vedha; Williams, Forman A.

    1999-01-01

    Classical understanding of diffusion flames dictates that they, unlike the premixed flames, do not possess a characteristic propagation velocity and are constrained by stoichiometric requirements at the flame surface. However, it has been commonly observed that when local extinction occurs within a diffusion flame sheet, the edges that are formed propagate with distinct speeds. In general, the propagation speed of these edges depend on their geometrical shape (concave, convex, or straight) among other factors. Recently, Buckmaster investigated the dynamics of straight diffusion flame edges separating burning and quenched regions using simplified one-dimensional models. He showed that these flame edges can have positive, negative, or zero velocity depending on the Damkoehler number of the equilibrium diffusion flame that support them. It was also shown that this unsteady flame-edge behavior is intrinsically linked to S-curve behavior of the diffusion flame with varying Damkoehler number. When the system Damkoehler number lies between the extinction and ignition limits, flame edges can propagate as an "ignition wave" or as a "failure wave," and for a critical Damkoehler number remain as a stationary flame-edge. We have extend Buckmaster's 1-d model to more general edge-flame configurations where the edges appear as "flame holes" or as "flame disks". These two configurations along with the straight-edge case cover the entire range of possible edge-flame geometry observable in planar diffusion-flame sheets. A generalized map of edge-flame propagation velocities as a function of the system Damkoehler number and the edge-flame radius is presented. Experimentally we show that edge flames can be created using diffusion flames embedded in von Karman boundary layers. In a von Karman boundary layer, the flow is generated by spinning a solid (fuel) disk in a quiescent ambient gas. Under normal gravity we were able to produce "flame disks" over a range of fuel-disk rotational

  2. Wernher von Braun and Saturn IB on Launch Pad

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher von Braun stands in front of a Saturn IB launch vehicle at Kennedy Space Flight Center. Dr. von Braun led a team of German rocket scientists, called the Rocket Team, to the United States, first to Fort Bliss/White Sands, later being transferred to the Army Ballistic Missile Agency at Redstone Arsenal in Huntsville, Alabama. They were further transferred to the newly established NASA/Marshall Space Flight Center (MSFC) in Huntsville, Alabama in 1960, and Dr. von Braun became the first Center Director. Under von Braun's direction, MSFC developed the Mercury-Redstone, which put the first American in space; and later the Saturn rockets, Saturn I, Saturn IB, and Saturn V. The Saturn V launch vehicle put the first human on the surface of the Moon, and a modified Saturn V vehicle placed Skylab, the first United States' experimental space station, into Earth orbit. Dr. von Braun was MSFC Director from July 1960 to February 1970.

  3. Distinguishability of countable quantum states and von Neumann lattice

    NASA Astrophysics Data System (ADS)

    Kawakubo, Ryûitirô; Koike, Tatsuhiko

    2016-07-01

    The condition for distinguishability of a countably infinite number of pure states by a single measurement is given. Distinguishability is to be understood as the possibility of an unambiguous measurement. For a finite number of states, it is known that the necessary and sufficient condition of distinguishability is that the states are linearly independent. For an infinite number of states, several natural classes of distinguishability can be defined. We give a necessary and sufficient condition for a system of pure states to be distinguishable. It turns out that each level of distinguishability naturally corresponds to one of the generalizations of linear independence to families of infinite vectors. As an important example, we apply the general theory to von Neumann’s lattice, a subsystem of coherent states which corresponds to a lattice in the classical phase space. We prove that the condition for distinguishability is that the area of the fundamental region of the lattice is greater than the Planck constant, and also find subtle behavior on the threshold. These facts reveal the measurement theoretical meaning of the Planck constant and give a justification for the interpretation that it is the smallest unit of area in the phase space. The cases of uncountably many states and of mixed states are also discussed.

  4. Grundsätze über die Anlagen neuer Sternwarten mit Beziehung auf die Sternwarte der Universität Göttingen. Von Georg Heinrich Borheck

    NASA Astrophysics Data System (ADS)

    Beuermann, Klaus; Borheck, Georg Heinrich

    Die Göttinger Sternwarte, Wirkungsstätte des berühmten Gelehrten Carl Friedrich Gauß, ist ein bedeutendes Baudenkmal. Im Jahre 2005 wird sie gemeinsam von der Georg-August-Universität und der Akademie der Wissenschaften zu Göttingen renoviert, um dann als repräsentatives Gebäude der Universität und Arbeitsstätte der Akademie zu dienen. Die Nutzung der historischen Räume für Ausstellungen macht diesen imposanten Bau erstmals der Öffentlichkeit zugänglich. Die Sternwarte war bei ihrer Errichtung vor 200 Jahren ein nach seinerzeit neuesten wissenschaftlichen Erkenntnissen konzipierter Bau, der die Universität Göttingen in eine der vordersten Stellen Europa rückte. Auch aufgrund ihrer Architektur ist sie ein großer Wurf des Göttinger Universitätsbaumeisters Georg Heinrich Borheck. Durch die Kriegswirren der Napoleonischen Zeit zerschlug sich Borhecks Versuch einer Publikation seiner Beschreibung des Baus der Göttinger Sternwarte 1805. Doch seine Schrift ist auch heute noch aktuell und wird mit diesem Band erstmals einer breiten Öffentlichkeit zugängig gemacht. Er zeigt die Grundsätze, nach denen damals öffentliche Bauten konzipiert wurden, erläutert die Bedeutung des Baus aus kunst- und wissenschaftshistorischer Sicht und informiert über die Pläne zur Restaurierung der Sternwarte in einem separaten Beitrag und im Geleitwort des Präsidenten der Georg-August Universität Prof. Dr. Dr. h. c. Kurt von Figura.

  5. Linkage disequilibrium patterns vary with chromosomal location: A case study from the von Willebrand factor region

    SciTech Connect

    Watkins, W.S.; Zenger, R.; O'Brien, E.; Jorde, L.B. ); Nyman, D. ); Eriksson, A.W. ); Renlund, M.

    1994-08-01

    Linkage disequilibrium analysis has been used as a tool for analyzing marker order and locating disease genes. Under appropriate circumstances, disequilibrium patterns reflect recombination events that have occurred throughput a population's history. As a result, disequilibrium mapping may be useful in genomic regions of <1 cM where the number of informative meioses needed to detect recombinant individuals within pedigrees is exceptionally high. Its utility for refining target areas for candidate disease genes before initiating chromosomal walks and cloning experiments will be enhanced as the relationship between linkage disequilibrium and physical distance is better understood. To address this issue, the authors have characterized linkage disequilibrium in a 144-kb region of the von Willebrand factor gene on chromosome 12. Sixty CEPH and 12 von Willebrand disease families were genotypes for five PCR-based markers, which include two microsatellite repeats and three single-base-pair substitutions. Linkage disequilibrium and physical distance between polymorphisms are highly correlated (r[sub m] = -.76; P<.05) within this region. None of the five markers showed significant disequilibrium with the von Willebrand disease phenotype. The linkage disequilibrium/physical distance relationship was also analyzed as a function of chromosomal location for this and eight previously characterized regions. This analysis revealed a general trend in which linkage disequilibrium dissipates more rapidly with physical distance in telomeric regions than in centromeric regions. This trend is consistent with higher recombination rates near telomeres. 52 refs., 3 figs., 4 tabs.

  6. Neurological surgery in the nineteenth century: the principles and techniques of Ernst von Bergmann.

    PubMed

    Hanigan, W C; Ragen, W; Ludgera, M

    1992-05-01

    Born in Latvia in 1836, Ernst von Bergmann received his medical education and first academic position at the University of Dorpat in Russia. In 1866, he served as a military surgeon in the Prusso-Austrian War, followed by duty in the Franco-Prussian War of 1870. He was appointed to the faculty of the University of Würzburg in 1878 and 4 years later moved to the University Clinic in Berlin. As a professor and chairman of surgery, he taught until his death in 1907. Von Bergmann practiced general surgery but devoted a large part of his career to the treatment of neurological diseases. Known for his development of aseptic technique, his early military experiences directed his attention to cranial trauma and, ultimately, neurosurgery. In 1880, he authored his first textbook, which described missile ballistics and animal experiments first demonstrating the physiological response later known as "the Cushing reflex" and advocated meticulous intracranial debridement with thorough closure after trauma. Twenty years later, as senior editor of the massive System of Practical Surgery, his contributions included pediatric neurosurgery, successful treatment of abscesses and tumors, diagnostic radiography, and cerebral localization using external landmarks and the neurological examination. Revered by his students and honored by his colleagues, von Bergmann became a proponent for aggressive neurosurgical treatment. His skilled techniques, developed in parallel with accurate experimental physiology, advanced 19th century surgical progression and formed a solid framework for the advances of neurosurgical specialists.

  7. Quantenphysik Interferometrie von C70-Molekülen

    NASA Astrophysics Data System (ADS)

    Ziegler, Thomas

    2002-05-01

    Interferenzversuche mit Neutronen und schweren Atomen stellen kein großes Problem mehr dar, selbst die Welleneigenschaften von C60-und C70-Molekülen wurden bereits nachgewiesen. Allerdings stößt man bei der Realisation immer feinerer Gitter mit Gitterkonstanten von etwa 100 nm im Fall dieser Moleküle auf technische Probleme. Wissenschaftlern der Universität Wien ist es jüngst gelungen, ein so genanntes Talbot-Lau-Interferometer zu realisieren und die Welleneigenschaften von C70 mit einer bislang unerreichten Qualität nachzuweisen [1].

  8. Von Neumann's growth model: Statistical mechanics and biological applications

    NASA Astrophysics Data System (ADS)

    De Martino, A.; Marinari, E.; Romualdi, A.

    2012-09-01

    We review recent work on the statistical mechanics of Von Neumann's growth model and discuss its application to cellular metabolic networks. In this context, we present a detailed analysis of the physiological scenario underlying optimality à la Von Neumann in the metabolism of the bacterium E. coli, showing that optimal solutions are characterized by a considerable microscopic flexibility accompanied by a robust emergent picture for the key physiological functions. This suggests that the ideas behind optimal economic growth in Von Neumann's model can be helpful in uncovering functional organization principles of cell energetics.

  9. A von Bertalanffy growth model with a seasonally varying coefficient

    USGS Publications Warehouse

    Cloern, James E.; Nichols, Frederic H.

    1978-01-01

    The von Bertalanffy model of body growth is inappropriate for organisms whose growth is restricted to a seasonal period because it assumes that growth rate is invariant with time. Incorporation of a time-varying coefficient significantly improves the capability of the von Bertalanffy equation to describe changing body size of both the bivalve mollusc Macoma balthicain San Francisco Bay and the flathead sole, Hippoglossoides elassodon, in Washington state. This simple modification of the von Bertalanffy model should offer improved predictions of body growth for a variety of other aquatic animals.

  10. [Work formation and experience in flexible automated production plants--analysis of an example from the VEB Combine Carl Zeiss JENA].

    PubMed

    Claussner, C; Müller, W

    1989-01-01

    Considering the production range pressure casting of the Combine VEB Carl Zeiss JENA as an example it will be made clear that--due to the development of low--service flexible automatic solutions--not only a lot conventional industrial-hygienic exposures/loads could be reduced but it is made a personality--furthering activity. The effect of work on the psychic good health of workers, the experience of the activity in order to the connected work contentment and the subjective analysis of the activity by the workers themselves are examined.

  11. Hermann von Helmholtz and the empiricist vision.

    PubMed

    Turner, R S

    1977-01-01

    The philosophical convictions of Hermann von Helmholtz and the empiricist psychology he developed have been extensively discussed in historical literature. This literature has not usually emphasized the tacti assumptions about human physiology that underlaid these convictions nor the way in which Helmholtz's epistemology served as a methodological directive in his research. Helmholtz assumed nerve transmission between sense organs and the mind to be a passive process. Distortion in stimulus patterns occurs physically in the sense organs, which can therefore be treated through mechanical analogies. Stimuli become converted to the perceptions of consciousness through mental processes that are essentially analogous to conscious, inductive inference and that are therefore susceptible, in principle, to introspective investigation. This view of mental function reflected Helmholtz's intellectual debt to German idealism, especially to the philosophical views of J.G. Fichte.

  12. Hermann von Helmholtz and his students

    NASA Astrophysics Data System (ADS)

    Mulligan, Joseph F.

    1989-01-01

    During the years 1871-1888, when Hermann von Helmholtz was professor of physics at the University of Berlin, physicists from all over the world flocked to Berlin to study and do research with him. Among these were the German physicists Max Planck, Heinrich Kayser, Eugen Goldstein, Wilhelm Wien, and Heinrich Hertz, and Americans Henry Rowland, A. A. Michelson, and Michael Pupin. Examples of Helmholtz's scientific and personal interactions with these students and research associates show why he is justly considered the outstanding physics mentor of the 19th century. Both his ideas and his students played a major role in the development of physics in the late 19th and early 20th centuries.

  13. Cooperation within von Willebrand factors enhances adsorption mechanism.

    PubMed

    Heidari, Maziar; Mehrbod, Mehrdad; Ejtehadi, Mohammad Reza; Mofrad, Mohammad R K

    2015-08-01

    von Willebrand factor (VWF) is a naturally collapsed protein that participates in primary haemostasis and coagulation events. The clotting process is triggered by the adsorption and conformational changes of the plasma VWFs localized to the collagen fibres found near the site of injury. We develop coarse-grained models to simulate the adsorption dynamics of VWF flowing near the adhesive collagen fibres at different shear rates and investigate the effect of factors such as interaction and cooperativity of VWFs on the success of adsorption events. The adsorption probability of a flowing VWF confined to the receptor field is enhanced when it encounters an adhered VWF in proximity to the collagen receptors. This enhancement is observed within a wide range of shear rates and is mostly controlled by the attractive van der Waals interactions rather than the hydrodynamic interactions among VWF monomers. The cooperativity between the VWFs acts as an effective mechanism for enhancing VWF adsorption to the collagen fibres. Additionally, this implies that the adsorption of such molecules is nonlinearly dependent on the density of flowing VWFs. These findings are important for studies of primary haemostasis as well as general adsorption dynamics processes in polymer physics.

  14. Multiple von Neumann computers: an evolutionary approach to functional emergence.

    PubMed

    Suzuki, H

    1997-01-01

    A novel system composed of multiple von Neumann computers and an appropriate problem environment is proposed and simulated. Each computer has a memory to store the machine instruction program, and when a program is executed, a series of machine codes in the memory is sequentially decoded, leading to register operations in the central processing unit (CPU). By means of these operations, the computer not only can handle its generally used registers but also can read and write the environmental database. Simulation is driven by genetic algorithms (GAs) performed on the population of program memories. Mutation and crossover create program diversity in the memory, and selection facilitates the reproduction of appropriate programs. Through these evolutionary operations, advantageous combinations of machine codes are created and fixed in the population one by one, and the higher function, which enables the computer to calculate an appropriate number from the environment, finally emerges in the program memory. In the latter half of the article, the performance of GAs on this system is studied. Under different sets of parameters, the evolutionary speed, which is determined by the time until the domination of the final program, is examined and the conditions for faster evolution are clarified. At an intermediate mutation rate and at an intermediate population size, crossover helps create novel advantageous sets of machine codes and evidently accelerates optimization by GAs.

  15. 1. Historic American Buildings Survey David von Riesen, Photographer July ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey David von Riesen, Photographer July 1965 BARRACKS (West), Left - BARRACKS (East), Right (Combined into New Barn) - Fort Larned, Barracks (West), Larned, Pawnee County, KS

  16. 1. Historic American Buildings Survey David von Riesen, Photographer July ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey David von Riesen, Photographer July 1965 BARRACKS (West), Left - BARRACKS (East), Right (Combined into New Barn) - Fort Larned, Barracks (East), Larned, Pawnee County, KS

  17. A proof of von Neumann's postulate in Quantum Mechanics

    SciTech Connect

    Conte, Elio

    2010-05-04

    A Clifford algebraic analysis is explained. It gives proof of von Neumann's postulate on quantum measurement. It is of basic significance to explain the problem of quantum wave function reduction in quantum mechanics.

  18. 33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE PERISCOPE FROM THE CONTROL ROOM AT TEST STAND NO. 1, PEENEMUENDE. - Marshall Space Flight Center, Redstone Rocket (Missile) Test Stand, Dodd Road, Huntsville, Madison County, AL

  19. Dr. Wernher Von Braun examines a ruby crystal.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, and Dr. Eberhard Rees (left), deputy director, technical, examine a ruby crystal used in laser experiments in the Marshall Center's Space Sciences Laboratory.

  20. Computed tomography of the liver in von Gierke's disease.

    PubMed

    Biondetti, P R; Fiore, D; Muzzio, P C

    1980-10-01

    The computed tomography findings in the liver of a patient with von Gierke's disease are presented. Precontrast scans demonstrated diffuse decreased density throughout the liver. In the postcontrast scans, a focal right sided hyperdense area was visualized. PMID:6931833

  1. Dr. von Braun Escorts President Kennedy and Vice President Johnson

    NASA Technical Reports Server (NTRS)

    1962-01-01

    Marshall Space Flight Center Director Dr. Wernher von Braun explains a detail from a Saturn IB mockup and engine to President John F. Kennedy, Vice President Lyndon Johnson and other guests, September 11, 1962.

  2. Physik gestern und heute Von der Metallstange zum Hochenergielaser

    NASA Astrophysics Data System (ADS)

    Heering, Peter

    2002-05-01

    Im Mai 1752 wurde in Marly bei Paris auf Anregung des amerikanischen Forschers und Politikers Benjamin Franklin erstmals die elektrische Natur des Blitzes nachgewiesen. Damals beschrieb Franklin auch eine technische Vorrichtung, die als Schutz von Gebäuden vor Blitzschlägen dienen sollte: den Blitzableiter. Diese aus heutiger Sicht scheinbar triviale Vorrichtung wurde aber keineswegs unmittelbar akzeptiert. Und bis heute ist die Forschung zum Schutz von Einrichtungen vor Blitzschlägen nicht abgeschlossen.

  3. America's First Carl Sagan: Ormsby MacKnight Mitchel, Pre-Civil War Astronomer and Lecturer on the Cosmos

    NASA Astrophysics Data System (ADS)

    Osterbrock, D. E.

    2002-12-01

    In the years before television, videos, radio. movies, or even loudspeakers, Ormsby MacKnight Mitchel (1809-1862) was the best-known popularizer of astronomy and the scientific study of the universe in nineteenth-century America. Each winter he traveled the country by railroad, steamer, and stagecoach, speaking to large paying crowds in principal cities from Boston, New York, and Philadelphia through Cincinnati to New Orleans on the cosmos and our place in it, with special attention to possible inhabitants of planers orbiting other stars. Mitchel had much the same attraction as Sagan did in our time, and awakened many people's interest in astronomy through the human angle, as Carl did. His argument was simple, and according to Frank Triplett goes back thousands of years: other stars are suns, our sun has planets with people on one of them, why should not other stars also have populated planets? But first Mitchel, like Sagan, always explained clearly the discoveries of astronomy that fleshed out this argument with facts. He emphasized the ``clockwork universe", governed by gravity, that Newton, Herschel, and Laplace had investigated and found to be stable. There were many other similarities between these two great popularizers. Mitchel's base was the Cincinnati Observatory, which he had founded, raising the funds for it himself in small contributions from hundreds of ``members", which he publicised as far more democratic than support from European kings and lords. He went abroad to get a telescope, and finally found his ``Great [12-inch] Refractor" in Munich, with help from John Quincy Adams, Astronomer Royal George Biddle Airy, and Paris Observatory Director Fracois Arago, in spite of a rebuff by President John Tyler. These episodes have similarities in Sagan's lobbying NASA for close-up images of Mars. Views of other American professional astronomers on life on other worlds will also be described briefly, from Denison Olmsted, Elias Loomis, Charles A. Young (who

  4. Carl Sagan's Cosmic Connection

    NASA Astrophysics Data System (ADS)

    Sagan, Carl; Agel, Jerome

    2000-08-01

    Foreword Freeman Dyson; Personal reflections Ann Druyan; Preface; Part I. Cosmic Perspective: 1. A transitional animal; 2. The Unicorn of Cetus; 3. A message from earth; 4. A message to earth; 5. Experiments in utopias; 6. Chauvinism; 7. Space exploration as a human enterprise I. The scientific interest; 8. Space exploration as a human enterprise II. The public interest; 9. Space exploration as a human enterprise III. The historical interest; Part II. The Solar System: 10. On teaching the first grade; 11. 'The ancient and legendary Gods of old'; 12. The Venus detective story; 13. Venus is hell; 14. Science and 'intelligence'; 15. The moons of Barsoom; 16. The mountains of Mars I. Observations from earth; 17. The mountains of Mars II. Observations from space; 18. The canals of Mars; 19. The lost pictures of Mars; 20. The Ice Age and the cauldron; 21. Beginnings and ends of the Earth; 22. Terraforming the plants; 23. The exploration and utlization of the solar system; Part III. Beyond the Solar System: 24. Some of my best friends are dolphins; 25. 'Hello, central casting? Send me twenty extraterrestrials'; 26. The cosmic connection; 27. Extraterrestrial life: an idea whose time has come; 28. Has the Earth been visited?; 29. A search strategy for detecting extraterrestrial intelligence; 30. If we succeed 31. Cables, drums, and seashells; 32. The night freight to the stars; 33. Astroengineering; 34. Twenty questions: a classification of cosmic civilisations; 35. Galactic cultural exchanges; 36. A passage to elsewhere; 37. Starfolk I. A Fable; 38. Starfolk II. A future; 39. Starfolk III. The cosmic Cheshire cats; Epilog David Morrison; Index.

  5. [Determination of von Willebrand factor multimers in Mexican population].

    PubMed

    Hernández-Zamora, Edgar; Zavala-Hernández, Cesar; Viveros-Sandoval, Martha Eva; Ochoa-Rico, Angeles; Martínez-Murillo, Carlos; Reyes-Maldonado, Elba

    2014-01-01

    Antecedentes: la enfermedad de von Willebrand es un padecimiento hereditario en el que la estructura, función y concentración del factor de von Willebrand están alteradas y, en consecuencia, también la interacción plaqueta-factor de von Willebrand-endotelio. En México no hay registros epidemiológicos de la enfermedad, sólo se han efectuado algunos estudios aislados desde el punto de vista clínico y hematológico. Material y métodos: estudio retrospectivo efectuado en 155 mexicanos mestizos, 75 de ellos con diagnóstico presuntivo de enfermedad de von Willebrand, 15 con sospecha de hemofilia A y 65 donadores sanos (testigos). Se realizaron pruebas: básicas de coagulación, especiales y de clasificación: análisis de la composición multimérica. Resultados: 15 pacientes se diagnosticaron con hemofilia A; de los 75 sujetos con sospecha de enfermedad de von Willebrand se diagnosticaron 50 de la manera siguiente: tipo 1 (62%), tipo 2 (22%) [subtipos: 2A (14%), 2B (2%) y 2N (6%)] y tipo 3 (16%). Conclusión: el análisis de los multímeros del factor de von Willebrand es un método que cumple con las características adecuadas para el diagnóstico de la enfermedad de von Willebrand, por lo que es necesario implementar esta metodología para su estudio y mejorar su diagnóstico específico.

  6. von Willebrand disease in the developing world.

    PubMed

    Srivastava, Alok

    2005-01-01

    von Willebrand disease (VWD) is considered to be the most common inherited bleeding disorder. Data on its epidemiology and impact in developing countries are limited. The biologic heterogeneity and variable presentation of VWD make diagnosis difficult. Although there is no accurate estimate of the prevalence of VWD in developing countries, available data suggest that the proportion of diagnosed cases is lower than the expected number, often accounting for only 6% to 13% of patients with hereditary bleeding disorders. Although accurate subtyping is often not possible, the number with severe disease tends to be much higher, particularly in those parts of the world where consanguinity is common. Agents used to treat patients with VWD range from plasma to purified factor concentrates. Desmopressin (DDAVP) is commonly used. Preliminary data on molecular genetics suggests that there are significant population differences. There is inadequate awareness of this condition and lack of support for these patients from the health care system in many developing countries. Concerted efforts are needed at the scientific and social levels to improve this situation. PMID:15662614

  7. The von Neumann Triple Point Paradox

    NASA Astrophysics Data System (ADS)

    Sanders, Richard; Tesdall, Allen M.

    We describe the problem of weak shock reflection off a wedge and discuss the triple point paradox that arises. When the shock is sufficiently weak and the wedge is thin, Mach reflection appears to be observed but is impossible according to what von Neumann originally showed in 1943. We summarize some recent numerical results for weak shock reflection problems for the unsteady transonic small disturbance equations, the nonlinear wave system, and the Euler equations. Rather than finding a standard but mathematically inadmissible Mach reflection with a shock triple point, the solutions contain a complex structure: there is a sequence of triple points and supersonic patches in a tiny region behind the leading triple point, with an expansion fan originating at each triple point. The sequence of patches may be infinite, and we refer to this structure as Guderley Mach reflection. The presence of the expansion fans at the triple points resolves the paradox. We describe some recent experimental evidence which is consistent with these numerical findings.

  8. Exponential Size Distribution of von Willebrand Factor

    PubMed Central

    Lippok, Svenja; Obser, Tobias; Müller, Jochen P.; Stierle, Valentin K.; Benoit, Martin; Budde, Ulrich; Schneppenheim, Reinhard; Rädler, Joachim O.

    2013-01-01

    Von Willebrand Factor (VWF) is a multimeric protein crucial for hemostasis. Under shear flow, it acts as a mechanosensor responding with a size-dependent globule-stretch transition to increasing shear rates. Here, we quantify for the first time, to our knowledge, the size distribution of recombinant VWF and VWF-eGFP using a multilateral approach that involves quantitative gel analysis, fluorescence correlation spectroscopy, and total internal reflection fluorescence microscopy. We find an exponentially decaying size distribution of multimers for recombinant VWF as well as for VWF derived from blood samples in accordance with the notion of a step-growth polymerization process during VWF biosynthesis. The distribution is solely described by the extent of polymerization, which was found to be reduced in the case of the pathologically relevant mutant VWF-IIC. The VWF-specific protease ADAMTS13 systematically shifts the VWF size distribution toward smaller sizes. This dynamic evolution is monitored using fluorescence correlation spectroscopy and compared to a computer simulation of a random cleavage process relating ADAMTS13 concentration to the degree of VWF breakdown. Quantitative assessment of VWF size distribution in terms of an exponential might prove to be useful both as a valuable biophysical characterization and as a possible disease indicator for clinical applications. PMID:24010664

  9. Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease

    PubMed Central

    Casonato, Alessandra; Cattini, Maria Grazia; Daidone, Viviana; Pontara, Elena; Bertomoro, Antonella; Prandoni, Paolo

    2016-01-01

    Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors. It may be difficult to recognize the different contributions of these anomalies. Here we demonstrate that VWD diagnostics gains from measuring platelet VWF, which can reveal a defective VWF synthesis. Measuring platelet VWF revealed that: severe type 1 VWD always coincided with significantly lower platelet and plasma VWF levels, whereas mild forms revealed low plasma VWF levels associated with low or normal platelet VWF levels, and the latter were associated with a slightly shorter VWF survival; type Vicenza (the archetype VWD caused by a reduced VWF survival) featured normal platelet VWF levels despite significantly reduced plasma VWF levels; type 2B patients could have either normal platelet VWF levels associated with abnormal multimer patterns, or reduced platelet VWF levels associated with normal multimer patterns; type 2A patients could have reduced or normal platelet VWF levels, the former associated mainly with type 2A-I, the latter with type 2A-II; plasma and platelet VWF levels were normal in type 2N, except when the defect was associated with a quantitative VWF mutation. Our findings show that measuring platelet VWF helps to characterize VWD, especially the ambiguous phenotypes, shedding light on the mechanisms underlying the disorder. PMID:27532107

  10. Characterization of aberrant splicing of von Willebrand factor in von Willebrand disease: an underrecognized mechanism.

    PubMed

    Hawke, Lindsey; Bowman, Mackenzie L; Poon, Man-Chiu; Scully, Mary-Frances; Rivard, Georges-Etienne; James, Paula D

    2016-07-28

    Approximately 10% of von Willebrand factor (VWF) gene mutations are thought to alter messenger RNA (mRNA) splicing through disruption of consensus splice sites. This mechanism is likely underrecognized and affected by mutations outside consensus splice sites. During VWF synthesis, splicing abnormalities lead to qualitative defects or quantitative deficiencies in VWF. This study investigated the pathologic mechanism acting in 3 von Willebrand disease (VWD) families with putative splicing mutations using patient-derived blood outgrowth endothelial cells (BOECs) and a heterologous human embryonic kidney (HEK 293(T)) cell model. The exonic mutation c.3538G>A causes 3 in-frame splicing variants (23del, 26del, and 23/26del) which cannot bind platelets, blood coagulation factor VIII, or collagen, causing VWD through dominant-negative intracellular retention of coexpressed wild-type (WT) VWF, and increased trafficking to lysosomes. Individuals heterozygous for the c.5842+1G>C mutation produce exon 33 skipping, exons 33-34 skipping, and WT VWF transcripts. Pathogenic intracellular retention of VWF lacking exons 33-34 causes their VWD. The branch site mutation c.6599-20A>T causes type 1 VWD through mRNA degradation of exon 38 skipping transcripts. Splicing ratios of aberrant transcripts and coexpressed WT were altered in the BOECs with exposure to shear stress. This study provides evidence of mutations outside consensus splice sites disrupting splicing and introduces the concept that VWF splicing is affected by shear stress on endothelial cells. PMID:27317792

  11. The Carl D. Perkins Vocational and Applied Technology Education Act Amendments of 1990. Conference Report To Accompany H.R. 7. House of Representatives, 101st Congress, 2d Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House.

    This document reports the committee of the conference's recommendation that the U.S. House of Representatives recede from its disagreement to the U.S. Senate amendment on the Carl D. Perkins Vocational and Applied Technology Education Act amendments of 1990. The first section provides materials the Senate would have inserted in the amendments. The…

  12. Locally Compact Quantum Groups. A von Neumann Algebra Approach

    NASA Astrophysics Data System (ADS)

    Van Daele, Alfons

    2014-08-01

    In this paper, we give an alternative approach to the theory of locally compact quantum groups, as developed by Kustermans and Vaes. We start with a von Neumann algebra and a comultiplication on this von Neumann algebra. We assume that there exist faithful left and right Haar weights. Then we develop the theory within this von Neumann algebra setting. In [Math. Scand. 92 (2003), 68-92] locally compact quantum groups are also studied in the von Neumann algebraic context. This approach is independent of the original C^*-algebraic approach in the sense that the earlier results are not used. However, this paper is not really independent because for many proofs, the reader is referred to the original paper where the C^*-version is developed. In this paper, we give a completely self-contained approach. Moreover, at various points, we do things differently. We have a different treatment of the antipode. It is similar to the original treatment in [Ann. Sci. & #201;cole Norm. Sup. (4) 33 (2000), 837-934]. But together with the fact that we work in the von Neumann algebra framework, it allows us to use an idea from [Rev. Roumaine Math. Pures Appl. 21 (1976), 1411-1449] to obtain the uniqueness of the Haar weights in an early stage. We take advantage of this fact when deriving the other main results in the theory. We also give a slightly different approach to duality. Finally, we collect, in a systematic way, several important formulas. In an appendix, we indicate very briefly how the C^*-approach and the von Neumann algebra approach eventually yield the same objects. The passage from the von Neumann algebra setting to the C^*-algebra setting is more or less standard. For the other direction, we use a new method. It is based on the observation that the Haar weights on the C^*-algebra extend to weights on the double dual with central support and that all these supports are the same. Of course, we get the von Neumann algebra by cutting down the double dual with this unique

  13. Entwicklungsperspektiven von Social Software und dem Web 2.0

    NASA Astrophysics Data System (ADS)

    Raabe, Alexander

    Der Artikel beschäftigt sich zunächst mit dem derzeitigen und zukünftigen Einsatz von Social Software in Unternehmen. Nach dem großen Erfolg von Social Software im Web beginnen viele Unternehmen eigene Social Software-Initiativen zu entwickeln. Der Artikel zeigt die derzeit wahrgenommenen Einsatzmöglichkeiten von Social Software im Unternehmen auf, erörtert Erfolgsfaktoren für die Einführung und präsentiert mögliche Wege für die Zukunft. Nach der Diskussion des Spezialfalles Social Software in Unternehmen werden anschließend die globalen Trends und Zukunftsperspektiven des Web 2.0 in ihren technischen, wirtschaftlichen und sozialen Dimensionen dargestellt. Wie aus den besprochenen Haupttrends hervorgeht, wird die Masse an digital im Web verfügbaren Informationen stetig weiterwachsen. So stellt sich die Frage, wie es in Zukunft möglich sein wird, die Qualität der Informationssuche und der Wissensgenerierung zu verbessern. Mit dem Einsatz von semantischen Technologien im Web wird hier eine revolutionäre Möglichkeit geboten, Informationen zu filtern und intelligente, gewissermaßen verstehende" Anwendungen zu entwerfen. Auf dem Weg zu einem intelligenten Web werden sich das Semantic Web und Social Software annähern: Anwendungen wie Semantic Wikis, Semantic Weblogs, lightweight Semantic Web-Sprachen wie Microformats oder auch kommerzielle Angebote wie Freebase von Metaweb werden die ersten Vorzeichen einer dritten Generation des Webs sein.

  14. Biographical sketch: Georg Hermann von Meyer (1815-1892).

    PubMed

    Skedros, John G; Brand, Richard A

    2011-11-01

    This biographical sketch on Georg Hermann von Meyer highlights the interactions in the 1860s that von Meyer, a famous anatomist, had with Karl Culmann, a famous structural engineer and mathematician. The published papers from this interaction caught the attention of Julius Wolff and stimulated his development of the trajectorial hypothesis of bone adaptation--now called "Wolff's Law." The corresponding translations are provided: (1) von Meyer's 1867 paper that highlights the regularity of arched trabecular patterns in various human bones, and his discussions with Culmann about their possible mechanical relevance; and (2) Wolff's 1869 paper that first mentions the correspondence of stress trajectories in a solid, crane-like structure to the arched trabecular patterns in the proximal human femur. This biographical sketch on Georg Hermann von Meyer corresponds to the historic texts, The Classic: The Architecture of the Trabecular bone (by von Meyer), and The Classic: On the Significance of the Architecture of the Spongy Substance for the Question of Bone Growth. A preliminary publication (by Wolff) available at DOIs 10.1007/s11999-011-2041-5 , 10.1007/s11999-011-2042-4 . PMID:21901583

  15. An Application of the Von Karman-millikan Laminar Boundary-layer Theory and Comparison with Experiment

    NASA Technical Reports Server (NTRS)

    Von Doenhoff, Albert E

    1935-01-01

    The von Karman-Millikan theory of laminar boundary layers presented in NACA Technical Report No. 504 is applied to the laminar boundary layer about an elliptic cylinder on which boundary-layer and pressure-distribution measurements were made. An outline of the procedure of the von Karman-Millikan method is given. Good agreement is obtained between the calculated and experimental results, indicating that the method may be applied generally to the laminar boundary layer about any body provided that an experimentally determined pressure distribution is available. It appears that for all Reynolds Number above 24,000 the separation point for the elliptic cylinder should occur at a constant distance behind the point of minimum pressure, provided that the boundary layer does not become turbulent.

  16. Relating sensation seeking and the von Restorff Isolation Effect.

    PubMed

    Cimbalo, Richard S; Clark, Douglas; Matayev, Aleksandr I

    2003-06-01

    Sensation seeking was examined in a short-term memory task involving the serial recall of a 10-item list of consonants with (isolated) and without (non-isolated) a distinctively larger item in the fifth position. 126 students were given the Sensation Seeking Scale Form-V and 32 10-item lists to memorize in a 1 by 3 mixed design. Sensation seeking was a between-subject factor and Blocks (Trials 1-16 and 17-32), Isolation (isolated and nonisolated), and Duration (2 sec. and 10 sec.) were within-subject factors. Generally nonisolated lists and the larger letters (the von Restorff Isolation Effect) were better recalled, with the latter being stronger at the shorter duration. Only the high sensation-seeking group showed a Blocks effect for lists with an isolated item such that there was a greater number of items correct per list in Block 1 than in Block 2. This finding is consistent with the argument that higher scores on sensation seeking are associated with greater cortical arousal and better memory for newness and change. Students with high sensation-seeking scores showed superior memory for the isolated list when it contained an isolate if allowed more processing time. It is argued that high sensation-seeking scores were associated with more effective transfer of items from shorter to longer-term memory. A rapid nontime-dependent perceptual process was used to explain the isolation effect. The poorer overall list performance for the lists with the isolate was explained in terms of the intense nature of the isolate.

  17. Gunther von Hagens' BODY WORLDS: selling beautiful education.

    PubMed

    Burns, Lawrence

    2007-04-01

    In the BODY WORLDS exhibitions currently touring the United States, Gunther von Hagens displays human cadavers preserved through plastination. Whole bodies are playfully posed and exposed to educate the public. However, the educational aims are ambiguous, and some aspects of the exhibit violate human dignity. In particular, the signature cards attached to the whole-body plastinates that bear the title, the signature of Gunther von Hagens, and the date of creation mark the plastinates as artwork and von Hagens as the artist in a gesture that strips the personal dignity from the donors. I conclude that the educational use of cadavers is compatible with respect for dignity if: 1) the utility of such use is great enough; 2) there are no other ways of achieving these ends; and 3) every effort is made to honor the dignity of the donors.

  18. Renaturierung von subalpinen und alpinen Ökosystemen

    NASA Astrophysics Data System (ADS)

    Krautzer, B.; Klug, Brigitte

    Die große Vielfalt an alpinen und subalpinen Ökosystemen auf waldfreien Standorten stellt besonders hohe Anforderungen an Planung und Durchführung von Renaturierungsmaßnahmen. Zunehmende Meereshöhe, starke Hangneigungen und extreme klimatische Verhältnisse im Gebirge bedingen zudem seit jeher natürliche Erosionsprozesse. Die zahllosen menschlichen Aktivitäten der letzten Jahrzehnte, gepaart mit unzureichenden Begrünungsmaßnahmen, erhöhen dieses Risiko noch um ein Vielfaches: Geländekorrekturen im Zuge von Skipistenbauten, Almrevitalisierungen, Forst- und Almwegebauten, Maßnahmen zur Verbesserung der touristischen Infrastruktur oder Wildbach- und Lawinenverbauungen. Nur durch Verwendung von hochwertigem, dem Standort angepasstem Pflanzen-oder Saatgutmaterial in Kombination mit der passenden Begrünungstechnik kann dieser Bedrohung dauerhaft entgegengewirkt werden. Dabei sind folgende limitierende Faktoren besonders zu beachten.

  19. Types of species of Apionidae (Coleoptera) described by Carl Peter Thunberg (1743–1828) with description of a new genus

    PubMed Central

    Alonso-Zarazaga, Miguel A.

    2013-01-01

    Abstract The type specimens of species of Apionidae described by Carl Peter Thunberg are reviewed and lecto- and paralectotypes are designated for Apion craccae Thunberg, 1813, Apion limbatum Thunberg, 1813, Apion punctigerum Thunberg, 1815 and Apion astragali Thunberg, 1815. A new genus Thunbergapion (type species Apion limbatum Thunberg, 1813) is described, figured and placed in the tribe Aplemonini Kissinger, 1968. The new combination Thunbergapion limbatum (Thunberg, 1813) is proposed. A key to the known South African genera of the tribe is given. The following new synonymies are established: Oxystoma craccae (Linnaeus, 1767) = Apion craccae Thunberg, 1813 syn. n., Ischnopterapion (Ischnopterapion) loti (Kirby, 1808) = Apion punctigerum Thunberg, 1815, syn. n., and Pseudoprotapion astragali (Paykull, 1800) = Apion astragali Thunberg, 1815, syn. n. PMID:23950673

  20. Phylogenetic analysis of the Australian trans-Bass Strait millipede genus Pogonosternum (Carl, 1912) (Diplopoda, Polydesmida, Paradoxosomatidae) indicates multiple glacial refugia in southeastern Australia

    PubMed Central

    Decker, Peter

    2016-01-01

    Abstract This study documents the first detailed phylogenetic analysis of an Australian paradoxosomatid millipede genus. Two mitochondrial genes (partial COI and 16S) as well as partial nuclear 28S rDNA were amplified and sequenced for 41 individuals of the southeastern Australian genus Pogonosternum Jeekel, 1965. The analysis indicates that five species groups of Pogonosternum occur across New South Wales, Victoria and Tasmania: Pogonosternum nigrovirgatum (Carl, 1912), Pogonosternum adrianae Jeekel, 1982, Pogonosternum laetificum Jeekel, 1982 and two undescribed species. Pogonosternum coniferum (Jeekel, 1965) specimens cluster within Pogonosternum nigrovirgatum. Most of these five species groups exhibit a pattern of high intraspecific genetic variability and highly localized haplotypes, suggesting that they were confined to multiple Pleistocene refugia on the southeastern Australian mainland. The phylogenetic data also show that northwestern Tasmania was colonized by Pogonosternum nigrovirgatum, probably from central Victoria, and northeastern Tasmania by an as yet undescribed species from eastern Victoria. PMID:27110194

  1. Modern embalming, circulation of fluids, and the voyage through the human arterial system: Carl L. Barnes and the culture of immortality in America.

    PubMed

    Podgorny, Irina

    2011-01-01

    By considering the work of American embalmer, lawyer, and physician Carl Lewis Barnes (1872-1927), this paper analyzes the emergence of modern embalming in America. Barnes experimented with and exhibited the techniques by which embalming fluids travelled into the most remote cavities of the human body. In this sense, modem embalmers based their skills and methods on experimental medicine, turning the anatomy of blood vessels, physiology of circulation, and composition of blood into a circuit that allowed embalming fluids to move throughout the corpse. Embalmers in the late 19th century took ownership of the laws of hydrodynamics and the physiology of blood circulation to market their fluids and equipment, thus playing the role of physiologists of death, performing and demonstrating physiological experiments with dead bodies.

  2. Allgemeine Sprachfaehigkeit und Fremdsprachenerwerb. Zur Struktur von Leistungsdimensionen und linguistischer Kompetenz des Fremdsprachenlerners (General Language Ability and Foreign Language Acquisition. On the Structure of Performance Dimensions and the Linguistic Competence of the Foreign Language Learner). Diskussions beitraege aus dem Institute fuer Bildungsforschung, No. 1.

    ERIC Educational Resources Information Center

    Sang, Fritz; Vollmer, Helmut J.

    This study investigates the theoretical plausibility and empirical validity of the assumption that all performance in a foreign language can be traced back to a single factor, the general language ability factor. The theoretical background of this hypothesis is reviewed in detail. The concept of a unitary linguistic competence, interpreted as an…

  3. Einblicke in die Dynamik von Quantensystemen: Elektrostatische Speicherringe

    NASA Astrophysics Data System (ADS)

    Welsch, Carsten P.

    2005-03-01

    Elektrostatische Speicherringe kombinieren die Vorteile elektrostatischer Fallen und klassischer magnetischer Speicherringe. Kompaktheit, gute Zugänglichkeit sämtlicher Elemente, hohe Flexibilität in der Wahl möglicher Experimente und die Eigenschaft, alle Teilchen unabhängig von ihrer Masse über einen weiten Geschwindigkeitsbereich zu speichern, bieten Zugang zu einem weiten experimentellen Spektrum. Insbesondere das Potenzial, das in neuartigen, energievariablen Maschinen in Kombination mit Elektronenkühlung, internen Targets und hochauflösenden Reaktionsmikroskopen steckt, verspricht hochinteressante Ergebnisse mit den unterschiedlichsten Teilchen - von exotischen Antiprotonen oder schweren radioaktiven Ionen bis hin zu einfachen und komplexen Molekülen oder Biosystemen.

  4. Renaturierung von Fließgewässern

    NASA Astrophysics Data System (ADS)

    Lüderitz, Volker; Jüpner, Robert

    Beim Umgang mit den Gewässern wurde der wasserbaulichen Durchsetzung bestimmter Nutzungsansprüche, vor allem der Landwirtschaft, dem Hochwasserschutz, der Wassergewinnung, der Schifffahrt und der Energiegewinnung über Jahrhunderte absoluter Vorrang vor den Belangen des ökologischen Zustandes der Gewässer selbst und damit auch ihrer multifunktionalen Nutzbarkeit eingeräumt. Die daraus resultierenden Umweltauswirkungen wurden oft billigend in Kauf genommen. Gezielte Verbesserungen der ökologischen Situation von Gewässern bzw. Gewässerabschnitten, wie z.B. der Einsatz ingenieurbiologischer Bauweisen oder der Einbau von Fischwanderhilfen an Mühlenstauen, blieben auf Ausnahmen beschränkt.

  5. An Accurate von Neumann's Law for Three-Dimensional Foams

    SciTech Connect

    Hilgenfeldt, Sascha; Kraynik, Andrew M.; Koehler, Stephan A.; Stone, Howard A.

    2001-03-19

    The diffusive coarsening of 2D soap froths is governed by von Neumann's law. A statistical version of this law for dry 3D foams has long been conjectured. A new derivation, based on a theorem by Minkowski, yields an explicit analytical von Neumann's law in 3D which is in very good agreement with detailed simulations and experiments. The average growth rate of a bubble with F faces is shown to be proportional to F{sup 1/2} for large F , in contrast to the conjectured linear dependence. Accounting for foam disorder in the model further improves the agreement with data.

  6. General Dentist

    MedlinePlus

    ... to your desktop! more... What Is a General Dentist? Article Chapters What Is a General Dentist? General ... Reviewed: January 2012 ?xml:namespace> Related Articles: General Dentists FAGD and MAGD: What Do These Awards Mean? ...

  7. [Anesthetic management of a child with moyamoya disease combined with von Gierke's disease].

    PubMed

    Takeuchi, Mitsue; Nohmi, Toshihiro; Ichikawa, Makiko; Ohnishi, Yoshihiko

    2010-02-01

    We report on a child with moyamoya disease combined with von Gierke's disease. A 7-year-old girl with von Gierke's disease had a stroke associated with moyamoya disease. She had had many episodes of hypoglycemia and severe metabolic acidosis before surgery. General anesthesia was induced with midazolam 3 mg and fentanyl 100 microg followed by rocuronium 12 mg. After tracheal intubation, anesthesia was maintained with sevoflurane 2.5% in 33% oxygen and 66% nitrous oxide. We used mainly mixture of saline and glucose as intraoperative fluid instead of acetated Ringer solution, and controlled administration of glucose according to blood glucose levels. The patient's plasma lactate levels and base excess during operation showed changes compared with those before operation, because sodium bicarbonate was used during the surgery. The duration of anesthesia was 374 minutes. The patient woke up and spontaneous respiration returned, and the trachea was extubated in the operating room. We were able to manage this case safely without any complications. PMID:20169974

  8. Targeted therapy for genetic cancer syndromes: Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome.

    PubMed

    Agarwal, Rishi; Liebe, Sarah; Turski, Michelle L; Vidwans, Smruti J; Janku, Filip; Garrido-Laguna, Ignacio; Munoz, Javier; Schwab, Richard; Rodon, Jordi; Kurzrock, Razelle; Subbiah, Vivek

    2015-02-01

    Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome are cancer syndromes which affect multiple organs and lead to significant decline in quality of life in affected patients. These syndromes are rare and typically affect the adolescent and young adult population, resulting in greater cumulative years of life lost. Improved understanding of the underpinnings of the genetic pathways underlying these syndromes and the rapid evolution of targeted therapies in general have made it possible to develop therapeutic options for these patients and other genetic cancer syndromes. Targeted therapies especially antiangiogenics and inhibitors of the PIK3CA/AKT/mTOR signaling pathway have shown activity in selected group of patients affected by these syndromes or in patients harboring specific sporadic mutations which are otherwise characteristic of these syndromes. Unfortunately due to the rare nature, patients with these syndromes are not the focus of clinical trials and unique results seen in these patients can easily go unnoticed. Most of the data suggesting benefits of targeted therapies are either case reports or small case series. Thus, a literature review was indicated. In this review we explore the use of molecularly targeted therapy options in Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome. PMID:25725225

  9. Real-space finite difference scheme for the von Neumann equation with the Dirac Hamiltonian

    NASA Astrophysics Data System (ADS)

    Schreilechner, Magdalena; Pötz, Walter

    2016-07-01

    A finite difference scheme for the numerical treatment of the von Neumann equation for the (2+1)D Dirac Hamiltonian is presented. It is based on a sequential left-right (ket-bra) application of a staggered space-time scheme for the pure-state Dirac equation and offers a numerical treatment of the general mixed-state dynamics of an isolated quantum system within the von Neumann equation. Thereby this direct scheme inherits all the favorable features of the finite-difference scheme for the pure-state Dirac equation, such as the single-cone energy-momentum dispersion, convergence conditions, and scaling behavior. A conserved functional is identified. Moreover this scheme is shown to conserve both Hermiticity and positivity. Numerical tests comprise a numerical analysis of stability, as well as the simulation of a mixed-state time-evolution of Gaussian wave functions, illustrating Zitterbewegung and transverse current oscillations. Imaginary-potential absorbing boundary conditions and parameters which pertain to topological insulator surface states were used in the numerical simulations.

  10. Pseudotumour of the Mandible Associated with von Willebrand's Disease.

    PubMed

    Daniel Sathiya, S S; Pari Selvakumar, P; Singh, Mandeep; Abraham, Aby; Koshy, Santosh

    2015-03-01

    Patients with bleeding disorders may occasionally present with pseudotumours. Most commonly these occur in the soft tissues and long bones, and are very rare in the maxillofacial region. We present the clinical details and management of a pseudotumour of the mandible in a 12-year-old girl with von Willebrand's disease.

  11. Treasure in the Library Attic: Von Ranke at Syracuse.

    ERIC Educational Resources Information Center

    Coville, Bruce

    1984-01-01

    Traces history of private library of German scholar, Leopold von Ranke, which was purchased by Syracuse University in 1888. Efforts of librarian Charles W. Bennett in 1870s and Professor James Powell beginning in late 1960s, and restoration and cataloging of collection are highlighted. Items from the collection are noted. (EJS)

  12. Dr. Wernher Von Braun near the mobile launcher.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

  13. Dr. Wernher Von Braun with Congressman Gerald R. fod

    NASA Technical Reports Server (NTRS)

    1999-01-01

    On a visit to the Marshall Space Flight Center in April, 1964, Congressman Gerald R. Ford, Jr. Republican of Michigan, was warmly greeted by Dr. Wernher Von Braun, Marshall Space Flight Center director. Ford, along with two other congressmen, visited the center for a briefing on the Saturn program and for a tour of the facilities.

  14. Dr. von Braun With a Model of a Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

  15. Von Kármán between Aachen and Pasadena

    NASA Astrophysics Data System (ADS)

    Krause, Egon; Kalkmann, Ulrich

    2013-05-01

    In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

  16. Renaturierung von Sandökosystemen im Binnenland

    NASA Astrophysics Data System (ADS)

    Schwabe-Kratochwil, Angelika; Kratochwil, Anselm

    Das Vorkommen von Sandökosystemen im Binnenland (Flugsand- und Decksandfelder, Dünen) ist vor allem an Sand-Akkumulationen der vorletzten Eiszeit (in Nordeuropa: Saaleeiszeit und Sand-Ablagerungen an größeren Flüssen gebunden. So finden wir die Verbreitungsschwerpunkte von binnenländischen Sandökosystemen in Mitteleuropa einerseits vor allem im Bereich der flächenhaften saalezeitlichen Ablagerungen in den Niederlanden und in Norddeutschland (Castel et al. 1989), andererseits kommen Sandökosysteme des Binnenlandes linear in den Flussgebieten z.B. von Maas, Rhein, Ems, Elbe, Oder und Regnitz vor. In Niederösterreich fanden sich einst großflächige Dünen- und Flugsandgebiete im Marchfeld östlich von Wien (Wiesbauer et al. 1997). Die Flugsandbildung setzte bereits im Spätglazial ca. 11000 v. Chr. ein, als eine den Sand fixierende Vegetation noch fehlte. Es bildeten sich im norddeutschen Raum aus den leicht verwehbaren Talsanden bereits um 9000 v. Chr.

  17. The education of Ehrenfried Walther von Tschirnhaus (1651-1708).

    PubMed

    Adler, Jacob

    2015-02-01

    Ehrenfried Walther von Tschirnhaus, mathematician, inventor, and correspondent of Spinoza, is often thought to have studied medicine at Leiden, though documentation of this fact has been lacking. Tschirnhaus' medical education is here documented, along with the nature of his medical practice. PMID:24585587

  18. Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure

    ERIC Educational Resources Information Center

    Joldersma, Clarence W.

    2011-01-01

    In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

  19. Wernher von Braun: Reflections on His Contributions to Space Exploration

    NASA Technical Reports Server (NTRS)

    Goldman, Arthur E.

    2012-01-01

    In 1950, Dr. Wernher von Braun and approximately 100 of his team members came to Huntsville, Alabama, to begin work with the Army on what would later become America's historic space program. He would later serve as the first director of the Marshall Space Flight Center and led the development of the Saturn V launch vehicle that launched seven crewed American mission to the moon, as well as America s first space station, Skylab. Von Braun is best known for his team s technical achievements. He realized his dream of exploring outer space by helping place humans on the moon. His engineering and managerial talent during the Apollo era had contributed to a technological revolution. He was by all accounts a good engineer, but he was only one among many. What set Von Braun apart were his charisma, his vision, and his leadership skills. He inspired loyalty and dedication in the people around him. He understood the importance of communicating his vision to his team, to political and business leaders and the public. Today, the Marshall Center continues his vision by pursuing engineering and scientific projects that will continue to open space to exploration. This presentation will discuss Von Braun's impact on Huntsville, the Marshall Center, the nation and the world and look at his contributions in context of where world space exploration is today.

  20. The education of Ehrenfried Walther von Tschirnhaus (1651-1708).

    PubMed

    Adler, Jacob

    2015-02-01

    Ehrenfried Walther von Tschirnhaus, mathematician, inventor, and correspondent of Spinoza, is often thought to have studied medicine at Leiden, though documentation of this fact has been lacking. Tschirnhaus' medical education is here documented, along with the nature of his medical practice.

  1. Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease.

    PubMed Central

    Levene, R B; Booyse, F M; Chediak, J; Zimmerman, T S; Livingston, D M; Lynch, D C

    1987-01-01

    Studies were conducted to characterize the biosynthesis of von Willebrand factor (vWf) by cultured endothelial cells (EC) derived from the umbilical vein of a patient with type IIA von Willebrand disease. The patient's EC, compared with those from normal individuals, produced vWf that had decreased amounts of large multimers and an increase in rapidly migrating satellite species, features characteristic of plasma vWf from patients with type IIA von Willebrand disease. The type IIA EC did produce a full spectrum of vWf multimers in both cell lysates and postculture medium, although the relative amounts of the largest species were decreased. The large multimers were degraded in conjunction with the appearance of rapidly migrating satellites that contained approximately equal to 170-kDa proteolytic fragments, suggesting that this patient's functional defect is due to abnormal proteolysis and not to a primary failure of vWf subunit oligomerization. Moreover, the observed degradation appears to result from an abnormal vWf molecule and not elevated protease levels. These results suggest that this patient's von Willebrand disease phenotype is caused by increased proteolytic sensitivity of his vWf protein. Images PMID:3306682

  2. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease

    PubMed Central

    Gill, Joan C.; Castaman, Giancarlo; Windyga, Jerzy; Kouides, Peter; Ragni, Margaret; Leebeek, Frank W. G.; Obermann-Slupetzky, Ortrun; Chapman, Miranda; Fritsch, Sandor; Pavlova, Borislava G.; Presch, Isabella

    2015-01-01

    This phase 3 trial evaluated the safety and hemostatic efficacy of a recombinant von Willebrand factor (rVWF) for treatment of bleeds in severe von Willebrand disease (VWD). rVWF was initially administered together with recombinant factor VIII (rFVIII) and subsequently alone, as long as hemostatic factor VIII activity (FVIII:C) levels were maintained. Pharmacokinetics (PK) were evaluated in a randomized cross-over design (rVWF vs rVWF:rFVIII at 50 IU VWF:ristocetin cofactor activity [RCo]/kg). Bleed control for all treated bleeds (N = 192 bleeds in 22 subjects) was rated good or excellent (96.9% excellent; 119 of 122 minor, 59 of 61 moderate, and 6 of 7 major bleeds) on a 4-point scale (4 = none to 1 = excellent). A single infusion was effective in 81.8% of bleeds. Treatment success, defined as the number of subjects with a mean efficacy rating of <2.5, was 100%. The PK profile of rVWF was not influenced by rFVIII (mean VWF:RCo terminal half-life: 21.9 hours for rVWF and 19.6 hours for rVWF:rFVIII). FVIII:C levels increased rapidly after rVWF alone, with hemostatic levels achieved within 6 hours and sustained through 72 hours after infusion. Eight adverse events (AEs; 6 nonserious AEs in 4 subjects and 2 serious AEs [chest discomfort and increased heart rate, without cardiac symptomatology] concurrently in 1 subject) were associated with rVWF. There were no thrombotic events or severe allergic reactions. No VWF or FVIII inhibitors, anti-VWF binding antibodies, or antibodies against host cell proteins were detected. These results show that rVWF was safe and effective in treating bleeds in VWD patients and stabilizes endogenous FVIII:C, which may eliminate the need for rFVIII after the first infusion. This trial was registered at www.clinicaltrials.gov as #NCT01410227. PMID:26239086

  3. PREFACE: EmerQuM 11: Emergent Quantum Mechanics 2011 (Heinz von Foerster Congress)

    NASA Astrophysics Data System (ADS)

    Grössing, Gerhard

    2012-05-01

    These proceedings comprise the plenary lectures and poster contributions of the 'Heinz von Foerster Conference 2011' on Emergent Quantum Mechanics (EmerQuM11), which was held at the University of Vienna, 11-13 November 2011. With the 5th International Heinz von Foerster Conference convened at the occasion of von Foerster's 100th birthday, the organizers opted for a twin conference to take place at the Large and Small Ceremonial Halls of the University's main building, respectively. The overall topic was chosen as 'Self-Organization and Emergence', a topic to which von Foerster was an early contributor. While the first conference ('Self-Organization and Emergence in Nature and Society') addressed a more general audience, the second one ('Emergent Quantum Mechanics') was intended as a specialist meeting with a contemporary topic that could both serve as an illustration of von Foerster's intellectual heritage and, more generally, point towards future directions in physics. We thus intended to bring together many of those physicists who are interested in or are working on attempts to understand quantum mechanics as emerging from a suitable classical (or, more generally, deeper level) physics. EmerQuM11 was organized by the Austrian Institute for Nonlinear Studies (AINS), with essential support from the Wiener Institute for Social Science Documentation and Methodology (WISDOM), the Department of Contemporary History at the University of Vienna, and the Heinz von Foerster-Gesellschaft. There were a number of individuals who contributed to the smooth course of our meeting and whom I would like to sincerely thank: Christian Bischof, Thomas Elze, Marianne Ertl, Gertrud Hafner, Werner Korn, Angelika Krawanja, Florian Krug and his team, Sonja Lang, Albert Müller, Ilse Müller, Irene Müller, Karl Müller, Armin Reautschnig, Marion Schirrmacher, Anton Staudinger, Roman Zlabinger, and, last but not least, my AINS colleagues Siegfried Fussy, Herbert Schwabl and Johannes Mesa

  4. ["Coca-Koller" and hist friends. On the 140th birthday of the Vienna Jewish trio: Carl Koller (1857-1944), Sigmund Lustgarten (1857-1911) and Sigmund Freud (1856-1939)].

    PubMed

    Amm, M; Holubar, K

    1997-03-14

    The lives of Carl Koller (1857-1944), Sigmund Lustgarten (1857-1911) and Sigmund Freud (1856-1939) are characterized by several interesting similarities. In their early achievements in medical research they were pathfinders of the first successful local anesthetic: cocaine. All three became later victims of antisemitism. Attention is paid to their personal relationship during their time in Vienna, on occasion of the 140th anniversary of their birth.

  5. Pathological Changes of von Economo Neuron and Fork Neuron in Neuropsychiatric Diseases.

    PubMed

    Liu, Jia; Wang, Lu-ning; Arzberger, Thomas; Zhu, Ming-wei

    2016-02-01

    von Economo neuron (VEN) is a bipolar neuron characterized by a large spindle-shaped soma. VEN is generally distributed in the layer V of anterior insular lobe and anterior cingulate cortex. Fork neuron is another featured bipolar neuron. In recent years,many studies have illustrated that VEN and fork neurons are correlated with complicated cognition such as self-consciousness and social emotion. Studies in the development and morpholigies of these two neurons as well as their pathological changes in various neurological and psychiatric disorders have found that the abnormal number and functions of VEN can cause corresponding dysfunctions in social recognition and emotions both during the neuro-developmental stages of childhood and during the nerve degeneration in old age stage. Therefore, more attentions should be paid on the research of VEN and fork neurons in neuropsychiatric diseases.

  6. The Influence of the Von Opel-Valier Experiments Upon German Rocket-Propelled Model Aircraft Development, 1920's-1930's

    NASA Astrophysics Data System (ADS)

    Winter, F. H.

    The following is a brief paper presented at the XXVIIIth International Astronautical Federation (IAF) Congress held in Prague, 25 September - 1 October 1977. Although it is generally assumed that recreational model rocketry, including commercially available kits, evolved during the Space Age, there were some interesting early predecessors, especially in Germany, that apparently arose as a result of the widespread reported rocket car and plane stunts of Fritz von Opel and Max Valier in the late 1920's.

  7. Generalized Bernoulli-Hurwitz numbers and the universal Bernoulli numbers

    NASA Astrophysics Data System (ADS)

    Ônishi, Yoshihiro

    2011-10-01

    The three fundamental properties of the Bernoulli numbers, namely, the von Staudt-Clausen theorem, von Staudt's second theorem, and Kummer's original congruence, are generalized to new numbers that we call generalized Bernoulli-Hurwitz numbers. These are coefficients in the power series expansion of a higher-genus algebraic function with respect to a suitable variable. Our generalization differs strongly from previous works. Indeed, the order of the power of the modulus prime in our Kummer-type congruences is exactly the same as in the trigonometric function case (namely, Kummer's own congruence for the original Bernoulli numbers), and as in the elliptic function case (namely, H. Lang's extension for the Hurwitz numbers). However, in other past results on higher-genus algebraic functions, the modulus was at most half of its value in these classical cases. This contrast is clarified by investigating the analogue of the three properties above for the universal Bernoulli numbers. Bibliography: 34 titles.

  8. Bleeding in renal failure: is von Willebrand factor implicated?

    PubMed Central

    Remuzzi, G; Livio, M; Roncaglioni, M C; Mecca, G; Donati, M B; de Gaetano, G

    1977-01-01

    Normal or increased concentrations of factor VIII procoagulant activity (VIIIC), factor VIII-related antigen (VIIIRA), and factor VIII-von Willebrand activity (VIIIVWF) were found in the predialysis plasma of 10 out of 11 patients with chronic renal failure (CRF). All patients had a bleeding time longer than 15 minutes and platelet retention to glass beads lower than 40%. The only patient who had reduced concentrations of all three factor VIII complex components was subsequently shown to have von Willebrand's disease. In four patients with CRF, very low platelet retention, and slightly prolonged bleeding time none of the three factor VIII COMPLEX COMPONENTS WERE SELECTIVely modified in predialysis samples. These findings suggest that the bleeding tendency common in CRF is not necessarily linked to defective plasma factor VIII-related activities. PMID:302134

  9. Marshall-Stickler phenotype associated with von Willebrand disease

    SciTech Connect

    MacDonald, M.R.; Baker, K.S.; Schaefer, G.B.

    1997-01-20

    We report on 6 individuals from three different kindreds with Marshall-Stickler (MS) phenotype, with characteristic orofacial abnormalities, arthropathy, deafness, and eye findings, all of whom were discovered to have a mild bleeding diathesis and coagulation-study findings consistent with mild von Willebrand disease (vWD). MS syndrome has been linked in some cases to the type II procollagen gene (COL2A1) on chromosome 12q, and to the collagen XI gene (COL11A2) on chromosome 6. The von Willebrand factor (vWF) is encoded by a 180-Kb gene located on the short arm of chromosome 12. This is the first reported association of these two disorders. 26 refs., 5 figs., 1 tab.

  10. Water Experiments Related To The "Von Karman Sodium" Dynamo Project

    NASA Astrophysics Data System (ADS)

    Marie, L.; Bourgoin, M.; Petrelis, F.; Roy, J.; Burguete, J.; Chiffaudel, A.; Daviaud, F.; Fauve, S.; Odier, P.; Pinton, J.-F.

    2002-07-01

    The purpose of the "Von Karman Sodium" (V.K.S.) experiment is to study the "Dynamo Effect," namely the spontaneous generation of magnetic field in a flow of electrically conducting fluid. The device has been built at CEA / Cadarache, in collaboration with CEA / Saclay, Ecole Normale Superieure de Lyon and Ecole Normale Superieure de Paris. It consists of a cylindrical vessel, filled with liquid Sodium, in which two coaxial rotating disks induce a Von-Karman type flow. Several experimental runs have taken place since June 2000. In order to optimize the V.K.S. set-up, a half-scale water prototype has also been built. It has allowed us to measure mean velocity profiles, as well as pressure fluctuations and mechanical power dissipation. We have observed that under certain circumstances the mean component of the turbulent flow can undergo a global bifurcation.

  11. Von eingebetteten Systemen zu Cyber-Physical Systems

    NASA Astrophysics Data System (ADS)

    Wedde, Rorst F.; Lehnhoff, Sebastian; Rehtanz, Christian; Krause, Olav

    Das Hauptanliegen des Papiers ist, ein Paradigma für Probleme mit neuartigen Integrationsanforderungen für Forschung und Entwicklung in verteilten eingebetteten Echtzeitsystemen zu motivieren und vorzustellen, nämlich den Begriff Cyber-Physical Systems. Bei einer in letzter Zeit stark zunehmenden Anzahl von Realzeitanwendungen können ohne die Berücksichtigung solcher Forderungen keine praktisch brauchbaren Lösungen erwartet werden. Einige Anwendungsfelder werden angesprochen. Im Einzelnen werden dann für Elektroautos, die mit erneuerbaren Energien betrieben werden sollen, einerseits die Management-, verteilte Verhandlungs- und Verteilungsprobleme der benötigten Energie in einem bottom-up Ansatz gelöst. Andererseits wird als Teil unserer Projektarbeit die Bereitstellung von Reserveenergie für den allgemeinen Bedarf durch Autobatterien vorgestellt. Es zeigt sich, dass dies effizienter und wesentlich kurzfristiger in unserem verteilten Vorgehen geschehen kann als in traditionellen Verfahren.

  12. A taxonomic synopsis of South American Cyanogomphini Carle with description of Cyanogomphus angelomachadoi sp. nov. from the Cerrado of Brazil (Odonata: Gomphidae).

    PubMed

    Pinto, Ângelo Parise; Almeida, Marcus Vinícius Oliveira De

    2016-01-01

    A synopsis of Cyanogomphini Carle, 1986 (sensu Belle 1996), including all species currently under the genera Cyanogomphus Selys, 1873, and Tibiagomphus Belle, 1992, is provided. Cyanogomphus angelomachadoi sp. nov. (Holotype ♂ deposited in DZRJ: Brazil, Minas Gerais State, Jaboticatubas municipality, Parque Nacional da Serra do Cipó, collecting site "Córrego das Pedras" 19°22'17"S, 43°36'03"W, 766 m a.s.l., 12.XII.2011, A.P.M. Santos & D.M. Takiya leg.) is described and illustrated based on four males and two females from Minas Gerais and São Paulo States, southeastern Brazil. The new species is most similar to C. waltheri Selys, 1873, from which it can be distinguished by its smaller size; larger pale areas on mesepisternum; pale dorsal surface of metathoracic tibia; larger distal concavity on epiproct, with laterodistal projection, in lateral view forefinger-shaped; and occurrence in Cerrado province. Five species are recognized in Cyanogomphini, and for each one a synonymy, diagnoses, identification key and maps of distribution are presented. The status of sibling taxa Tibiagomphus uncatus (Fraser, 1947) and T. noval (Rodrigues Capítulo, 1985), as well as the Agriogomphus-complex of genera are also discussed.

  13. A taxonomic synopsis of South American Cyanogomphini Carle with description of Cyanogomphus angelomachadoi sp. nov. from the Cerrado of Brazil (Odonata: Gomphidae).

    PubMed

    Pinto, Ângelo Parise; Almeida, Marcus Vinícius Oliveira De

    2016-01-01

    A synopsis of Cyanogomphini Carle, 1986 (sensu Belle 1996), including all species currently under the genera Cyanogomphus Selys, 1873, and Tibiagomphus Belle, 1992, is provided. Cyanogomphus angelomachadoi sp. nov. (Holotype ♂ deposited in DZRJ: Brazil, Minas Gerais State, Jaboticatubas municipality, Parque Nacional da Serra do Cipó, collecting site "Córrego das Pedras" 19°22'17"S, 43°36'03"W, 766 m a.s.l., 12.XII.2011, A.P.M. Santos & D.M. Takiya leg.) is described and illustrated based on four males and two females from Minas Gerais and São Paulo States, southeastern Brazil. The new species is most similar to C. waltheri Selys, 1873, from which it can be distinguished by its smaller size; larger pale areas on mesepisternum; pale dorsal surface of metathoracic tibia; larger distal concavity on epiproct, with laterodistal projection, in lateral view forefinger-shaped; and occurrence in Cerrado province. Five species are recognized in Cyanogomphini, and for each one a synonymy, diagnoses, identification key and maps of distribution are presented. The status of sibling taxa Tibiagomphus uncatus (Fraser, 1947) and T. noval (Rodrigues Capítulo, 1985), as well as the Agriogomphus-complex of genera are also discussed. PMID:27395962

  14. Carl Ludwig's (1847) and Pavel Petrovich Einbrodt's (1860) physiological research and its implications for modern cardiovascular science: translator's notes relating to the English translation of two seminal papers.

    PubMed

    Schaefer, Jochen; Lohff, Brigitte; Dittmer, Janke Jörn

    2014-08-01

    Respiratory interactions with the heart have remained a challenging physiological phenomenon since their discovery more than two hundred and fifty years ago. In the course of translating the seminal publications of Carl Ludwig and his disciple Pavel Petrovich Einbrodt into English, we became aware of some under-appreciated aspects of their work that contain useful insights into the history of the phenomenon now called respiratory arrhythmia. Ludwig observed arrhythmic effects of respiratory movements in experiments on dogs and horses and published his findings in 1847. He subsequently undertook further work on this problem, together with Einbrodt. Already in 1847 Ludwig had mentioned an exciting observation on the possible role of mechanical factors of the respiratory movements on the action of the heart in a dog in whom he had artificially induced bouts of coughing. Einbrodt decided to systematically develop methods to increase or decrease the pressure of the air the animal had to breathe. He observed that this procedure led to a greater or lesser degree of compression or decompression of all the organs in the thoracic cavity without apparently causing harmful consequences during the time of its application. How the mechanical influence of breathing affects cardiac activity during respiratory arrhythmia has been the subject of scientific discussions and controversies over a period of more than 150 years and is still unresolved. Recent publications suggest that cardiac mechano-electrical coupling plays an important role in the emergence of cardio-respiratory interdependence.

  15. Dr. von Braun In Front of a Display of Missiles

    NASA Technical Reports Server (NTRS)

    1960-01-01

    In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

  16. Von Gierke's disease adopts an orphan (and its partner).

    PubMed

    Cheng, Alan; Saltiel, Alan R

    2009-01-01

    The enzyme glucose-6-phosphatase is critical for maintaining fasting blood sugar levels by increasing hepatic glucose production. Its absence in patients with von Gierke's disease leads to severe hypoglycemia and abnormal accumulation of glycogen (glycogenosis) in the liver. New players that control the expression of glucose-6-phosphatase have been identified that may provide insight into this metabolic disorder, as well as type 2 diabetes. PMID:19224896

  17. Von Humboldt bis Einstein. Berlin als Weltzentrum der exakten Wissenschaften.

    NASA Astrophysics Data System (ADS)

    Meschkowski, H.

    Contents: 1. Die Anfänge. 2. Die Ära Dirichlet-Jacobi. 3. Der Ausbau der experimentellen Naturwissenschaften. 4. Alexander von Humboldt. 5. Berlin wird "Weltzentrum" der Mathematik. 6. Die Ära Helmholtz. 7. Neue Arbeitsweisen der Astronomie. 8. Chemie: Forschung und Industrie. 9. Max Planck. 10. Ins technische Zeitalter. 11. Zur Mathematik der zwanziger Jahre. 12. Albert Einstein. 13. Fortschritte der Grundlagenforschung. 14. Erwin Schrödinger: Physiker, Philosoph und Poet. 15. Zum Schluß.

  18. Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

    NASA Astrophysics Data System (ADS)

    Schneider, Ivo

    The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

  19. Interpolatability distinguishes LOCC from separable von Neumann measurements

    SciTech Connect

    Childs, Andrew M.; Leung, Debbie; Mančinska, Laura; Ozols, Maris

    2013-11-15

    Local operations with classical communication (LOCC) and separable operations are two classes of quantum operations that play key roles in the study of quantum entanglement. Separable operations are strictly more powerful than LOCC, but no simple explanation of this phenomenon is known. We show that, in the case of von Neumann measurements, the ability to interpolate measurements is an operational principle that sets apart LOCC and separable operations.

  20. von Braun and Buckbee View Demonstration at Space Science Center

    NASA Technical Reports Server (NTRS)

    1960-01-01

    Edward O. Buckbee, the first Director of the Alabama Space Science Center (left), and Dr. Wernher von Braun (right) view a demonstration of a simulated spacecraft which uses an actual hybrid rocket engine for liftoff, hover, and landing. The display was presented to the Alabama Space Science Center, later renamed the U.S. Space and Rocket Center, by United Technology Center, a division of United Aircraft.

  1. Study of types of some species of “Filaria” (Nematoda) parasites of small mammals described by von Linstow and Molin

    PubMed Central

    Guerrero, R.; Bain, O.

    2011-01-01

    Parasitic nematodes from the Berlin (ZMB) and Vienna (NMW) Museum collections referred to the genus Filaria Mueller, 1787 by von Linstow or Molin were studied. Three samples were in good condition and the specimens redescribed. Litomosa hepatica (von Linstow, 1897) n. comb., sample ZMB Vermes Entozoa 3368, from the megachiropteran Pteropus neohibernicus, Bismarck Archipelago, resembles L. maki Tibayrenc, Bain & Ramanchandran, 1979, from Pteropus vampyrus, in Malaysia, but the buccal capsule differs. Both species display particular morphological characters which differ from species of Litomosa parasitic in microchiropterans. The remaining material originates from Brazil. The spicule morphology of Litomosoides circularis (von Linstow, 1899) Chandler, 1931, sample ZMB Vermes Entozoa 1059 from Hesperomys spec. (= Holochilus brasiliensis), Porto Alegre, confirms that it belongs to the sigmodontis group; the microfilaria presents characters of the genus Litomosoides, e.g. body attenuated at both extremities and salient cephalic hook. Taxonomic discussions by others confirm that species of Litomosoides belonging to the sigmodontis group and described subsequently are distinct from L. circularis. Litomosoides serpicula (Molin, 1858) Guerrero, Martin, Gardner & Bain, 2002, is redescribed, sample NMW 6323 from the bat Phyllostoma spiculatum (= Sturnira lilium), Ypanema. It is very close to L. brasiliensis Almeida, 1936, type host Moytis sp., but distinguished by a single ring in the buccal capsule, rather than two, supporting previous conclusions that the taxon L. brasiliensis, as generally regarded, may represent a complex of species. Samples NMW 6322 and NMW 6324, from other bats and also identified by Molin (1858) as Filaria serpicula, contain unidentifiable fragments of Litomosoides incertae sedis. Filaria hyalina von Linstow, 1890, sample ZMB Vermes Entozoa Q 3905 from Sorex vulgaris (= Sorex araneus), is incertae sedis because it contains two unidentifiable posterior

  2. Radiometric Trouble with Rough Surfaces? ... The von Neumann Series can Help!

    NASA Astrophysics Data System (ADS)

    Davis, A. B.

    2004-05-01

    Operational retrieval methods used in surface remote sensing will generally assume that the interrogated terrain is uniform as well as flat (if not outright horizontal) at least at sub-pixel scales. Both assumptions are highly questionable. There are spectral techniques (linear un-mixing, end-members, etc.) designed to address the non-uniformity issue and adjacency effects (nonlinear mixing) near large gradients in surface albedo can be unraveled with techniques using the Green function of the aerosol atmosphere. But strong deviations from local flatness define a challenging problem in three-dimensional radiative transfer; this is especially true when the terrain has a very rough fractal shape with height variability over a wide range of scales. The source of the problem is the multiple reflections between surface elements in view of each other and is mathematically akin to the problem of multiple scattering in heterogeneous turbid media like clouds. The fundamental solution to the multiple scattering/reflection problem in transport theory is called ``successive orders-of-scattering/reflection'' by physicists and a ``von Neumann expansion'' by mathematicians. I have applied this method to the analysis of two remote sensing problems that appear to be vastly different: (1) angular dependence of effective emissivity in thermal remote sensing, and (2) biases in fine laser altimetry (such as attempted by NASA's present GLAS mission which focuses on polar ice caps). The thermal problem can be reduced to a question of mean aspect ratio in the macro-roughness of the surface. The altimetry problem calls furthermore for a roughness scale. In both cases, corrections can be made to obtain the surface property of interest: actual emissivity, and actual altitude. In both cases, Monte Carlo simulation ---another seminal contribution of John von Neumann, with others--- was the key to first inspiring and then validating the proposed analytical models with one or two free parameters

  3. Context-invariant quasi hidden variable (qHV) modelling of all joint von Neumann measurements for an arbitrary Hilbert space

    NASA Astrophysics Data System (ADS)

    Loubenets, Elena R.

    2015-03-01

    We prove the existence for each Hilbert space of the two new quasi hidden variable (qHV) models, statistically noncontextual and context-invariant, reproducing all the von Neumann joint probabilities via non-negative values of real-valued measures and all the quantum product expectations—via the qHV (classical-like) average of the product of the corresponding random variables. In a context-invariant model, a quantum observable X can be represented by a variety of random variables satisfying the functional condition required in quantum foundations but each of these random variables equivalently models X under all joint von Neumann measurements, regardless of their contexts. The proved existence of this model negates the general opinion that, in terms of random variables, the Hilbert space description of all the joint von Neumann measurements for dim H ≥ 3 can be reproduced only contextually. The existence of a statistically noncontextual qHV model, in particular, implies that every N-partite quantum state admits a local quasi hidden variable model introduced in Loubenets [J. Math. Phys. 53, 022201 (2012)]. The new results of the present paper point also to the generality of the quasi-classical probability model proposed in Loubenets [J. Phys. A: Math. Theor. 45, 185306 (2012)].

  4. Context-invariant quasi hidden variable (qHV) modelling of all joint von Neumann measurements for an arbitrary Hilbert space

    SciTech Connect

    Loubenets, Elena R.

    2015-03-15

    We prove the existence for each Hilbert space of the two new quasi hidden variable (qHV) models, statistically noncontextual and context-invariant, reproducing all the von Neumann joint probabilities via non-negative values of real-valued measures and all the quantum product expectations—via the qHV (classical-like) average of the product of the corresponding random variables. In a context-invariant model, a quantum observable X can be represented by a variety of random variables satisfying the functional condition required in quantum foundations but each of these random variables equivalently models X under all joint von Neumann measurements, regardless of their contexts. The proved existence of this model negates the general opinion that, in terms of random variables, the Hilbert space description of all the joint von Neumann measurements for dimH≥3 can be reproduced only contextually. The existence of a statistically noncontextual qHV model, in particular, implies that every N-partite quantum state admits a local quasi hidden variable model introduced in Loubenets [J. Math. Phys. 53, 022201 (2012)]. The new results of the present paper point also to the generality of the quasi-classical probability model proposed in Loubenets [J. Phys. A: Math. Theor. 45, 185306 (2012)].

  5. 78 FR 61948 - Culturally Significant Objects Imported for Exhibition Determinations: “Franz von Stuck”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-07

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Franz von Stuck'' SUMMARY: Notice is..., I hereby determine that the objects to be included in the exhibition ``Franz von Stuck,'' imported... objects are imported pursuant to loan agreements with the foreign owners or custodians. I also...

  6. 76 FR 36166 - Culturally Significant Objects Imported for Exhibition; Determinations: “Gabriel von Max: Be...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition; Determinations: ``Gabriel von Max: Be-Tailed Cousins... the exhibition ``Gabriel von Max: Be-Tailed Cousins and Phantasms of the Soul,'' imported from...

  7. The Fate of Western Civilization: G. H. von Wright's Reflections on Science, Technology, and Global Society

    ERIC Educational Resources Information Center

    Heikkero, Topi

    2004-01-01

    This article introduces the central ideas of G. H. von Wright's cultural philosophy concerning the techno-scientific form of life. Georg Henrik von Wright (1916-2003) was best known for his achievements in the field of modal logic and for his association with Ludwig Wittgenstein. However, his work also included a critical analysis of science and…

  8. Spin torque oscillator neuroanalog of von Neumann's microwave computer.

    PubMed

    Hoppensteadt, Frank

    2015-10-01

    Frequency and phase of neural activity play important roles in the behaving brain. The emerging understanding of these roles has been informed by the design of analog devices that have been important to neuroscience, among them the neuroanalog computer developed by O. Schmitt and A. Hodgkin in the 1930s. Later J. von Neumann, in a search for high performance computing using microwaves, invented a logic machine based on crystal diodes that can perform logic functions including binary arithmetic. Described here is an embodiment of his machine using nano-magnetics. Electrical currents through point contacts on a ferromagnetic thin film can create oscillations in the magnetization of the film. Under natural conditions these properties of a ferromagnetic thin film may be described by a nonlinear Schrödinger equation for the film's magnetization. Radiating solutions of this system are referred to as spin waves, and communication within the film may be by spin waves or by directed graphs of electrical connections. It is shown here how to formulate a STO logic machine, and by computer simulation how this machine can perform several computations simultaneously using multiplexing of inputs, that this system can evaluate iterated logic functions, and that spin waves may communicate frequency, phase and binary information. Neural tissue and the Schmitt-Hodgkin, von Neumann and STO devices share a common bifurcation structure, although these systems operate on vastly different space and time scales; namely, all may exhibit Andronov-Hopf bifurcations. This suggests that neural circuits may be capable of the computational functionality as described by von Neumann.

  9. Orthopaedic surgery in patients with von Willebrand disease.

    PubMed

    Siboni, S M; Biguzzi, E; Solimeno, L P; Pasta, G; Mistretta, C; Mannucci, P M; Peyvandi, F

    2014-01-01

    Patients with von Willebrand disease (VWD) may need orthopaedic surgery because of disabling chronic arthropathy due to recurrent joint bleeding. They may also require this surgery independently of their haemostasis disorder. Knowledge regarding the management of orthopaedic surgery in VWD is limited. Description of management of orthopaedic surgery in patients with VWD, based upon retrospective data collection and analysis of 32 orthopaedic procedures carried out over a period of 33 years in 23 patients was the aim of this study. Of 32 procedures, six were minor (three hand surgery, one foot surgery, two others) and 26 were major (seven joint replacements, nine arthroscopic procedures, two foot surgery, eight others). Twenty-two procedures were performed using replacement therapy with plasma-derived concentrates containing both factor VIII (FVIII) and von Willebrand factor (VWF). Two procedures in patients with acquired von Willebrand syndrome (AWVS) were performed using FVIII-VWF concentrates associated with intravenous immunoglobulins, or desmopressin plus tranexamic acid. Seven procedures were performed using desmopressin alone and one using intravenous immunoglobulins in AVWS. Bleeding complications occurred in seven procedures (22%). In one patient, an anti-VWF antibody was diagnosed after surgery. Anticoagulant prophylaxis of venous thromboembolism was implemented in four cases only and in two instances there was excessive bleeding. In conclusion, control of surgical haemostasis was achieved in most patients with VWD undergoing orthopaedic surgery. The control of haemostasis combined with an adequate surgical technique and early post-operative rehabilitation are warranted for the successful performance of orthopaedic surgery in VWD, which requires the involvement of specialized haemophilia centres.

  10. Von Willebrand factor regulates complement on endothelial cells.

    PubMed

    Noone, Damien G; Riedl, Magdalena; Pluthero, Fred G; Bowman, Mackenzie L; Liszewski, M Kathryn; Lu, Lily; Quan, Yi; Balgobin, Steve; Schneppenheim, Reinhard; Schneppenheim, Sonja; Budde, Ulrich; James, Paula; Atkinson, John P; Palaniyar, Nades; Kahr, Walter H A; Licht, Christoph

    2016-07-01

    Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise in thrombotic thrombocytopenic purpura. However, recent studies suggest that both entities are related as defects in the disease-causing pathways overlap or show functional interactions. Here we investigate the possible functional link of VWF-multimers and the complement system on endothelial cells. Blood outgrowth endothelial cells (BOECs) were obtained from 3 healthy individuals and 2 patients with Type 3 von Willebrand disease lacking VWF. Cells were exposed to a standardized complement challenge via the combination of classical and alternative pathway activation and 50% normal human serum resulting in complement fixation to the endothelial surface. Under these conditions we found the expected release of VWF-multimers causing platelet adhesion onto BOECs from healthy individuals. Importantly, in BOECs derived from patients with von Willebrand disease complement C3c deposition and cytotoxicity were more pronounced than on BOECs derived from normal individuals. This is of particular importance as primary glomerular endothelial cells display a heterogeneous expression pattern of VWF with overall reduced VWF abundance. Thus, our results support a mechanistic link between VWF-multimers and the complement system. However, our findings also identify VWF as a new complement regulator on vascular endothelial cells and suggest that VWF has a protective effect on endothelial cells and complement-mediated injury. PMID:27236750

  11. Spin torque oscillator neuroanalog of von Neumann's microwave computer.

    PubMed

    Hoppensteadt, Frank

    2015-10-01

    Frequency and phase of neural activity play important roles in the behaving brain. The emerging understanding of these roles has been informed by the design of analog devices that have been important to neuroscience, among them the neuroanalog computer developed by O. Schmitt and A. Hodgkin in the 1930s. Later J. von Neumann, in a search for high performance computing using microwaves, invented a logic machine based on crystal diodes that can perform logic functions including binary arithmetic. Described here is an embodiment of his machine using nano-magnetics. Electrical currents through point contacts on a ferromagnetic thin film can create oscillations in the magnetization of the film. Under natural conditions these properties of a ferromagnetic thin film may be described by a nonlinear Schrödinger equation for the film's magnetization. Radiating solutions of this system are referred to as spin waves, and communication within the film may be by spin waves or by directed graphs of electrical connections. It is shown here how to formulate a STO logic machine, and by computer simulation how this machine can perform several computations simultaneously using multiplexing of inputs, that this system can evaluate iterated logic functions, and that spin waves may communicate frequency, phase and binary information. Neural tissue and the Schmitt-Hodgkin, von Neumann and STO devices share a common bifurcation structure, although these systems operate on vastly different space and time scales; namely, all may exhibit Andronov-Hopf bifurcations. This suggests that neural circuits may be capable of the computational functionality as described by von Neumann. PMID:26135205

  12. Kernschmelze Der nachhaltige Einfluss von Nuklearwaffen auf Politik und Wirtschaft

    NASA Astrophysics Data System (ADS)

    Greiner, Bernd

    "Was sollen wir von einer Kultur halten, der die Ethik stets als wesentliches Element des menschlichen Lebens galt, die aber - außer in fachlicher oder spieltheoretischer Terminologie - nicht in der Lage war, über die Möglichkeit zu sprechen, nahezu alle Menschen zu töten?" Der Fragesteller gehört zu den berühmtesten Physikern des 20. Jahrhunderts und zu den nach wie vor Umstrittensten. über ihn wurde in den 1960er Jahren ein international viel beachtetes Theaterstück geschrieben, vor wenigen Jahren gar eine Oper.

  13. Karl Ernst von Baer (1792-1876) and evolution.

    PubMed

    Brauckmann, Sabine

    2012-01-01

    The research program of Karl Ernst von Baer (1792-1876) intended to enhance the comparative approach of animal classification by demonstrating vertebrate affinities (homology). Baer visualized his ideas on development and evolution with an unpublished figure of a branching tree. To buttress his reflections on how species-specific embryogenesis produces a branching tree, he worked out a cladogram-like chart, depicting the ontogeny and phylogeny of vertebrate embryos. For Baer, changes in development were responsible for changes in phenotype. I will offer a new interpretation of Baer's ideas about evolution showing that he believed in the transformation of species and announced such views publicly. PMID:23319342

  14. [Heinrich von Kleist and the true nature of man].

    PubMed

    Larsen, O

    1998-12-10

    In short-stories, novels and plays, the artist's interpretation of human nature may render the reader valuable insights into the basics of human behaviour. This article is a discussion of a short-story about a fictitious earthquake in Chile, written in 1807 by Heinrich von Kleist (1777-1811). The writer shows how feelings of warmth, friendliness and solidarity come out when a catastrophe reduces the relative importance of man-made rules and regulations. But more sombre sides of human nature also come to the surface in the wake of the disaster, and the writer indicates that even the apparently virtuous Christian morality contains severe traits of cruelty and repressiveness.

  15. Karl Ernst von Baer (1792-1876) and evolution.

    PubMed

    Brauckmann, Sabine

    2012-01-01

    The research program of Karl Ernst von Baer (1792-1876) intended to enhance the comparative approach of animal classification by demonstrating vertebrate affinities (homology). Baer visualized his ideas on development and evolution with an unpublished figure of a branching tree. To buttress his reflections on how species-specific embryogenesis produces a branching tree, he worked out a cladogram-like chart, depicting the ontogeny and phylogeny of vertebrate embryos. For Baer, changes in development were responsible for changes in phenotype. I will offer a new interpretation of Baer's ideas about evolution showing that he believed in the transformation of species and announced such views publicly.

  16. Karl ernst von Baer's 'Uber Entwickelungsgeschichte der Thiere II' and its unpublished drawings.

    PubMed

    Tammiksaar, Erki; Brauckmann, Sabine

    2004-01-01

    In 1828 Karl Ernst von Baer (1792-1876) published his seminal Uber Entwickelungsgeschichte der Thiere. Beobachtung und Reflexion. In the preface he announced that a second volume with one copper plate would be finished 'in a few weeks'. However, it took nine years until the unfinished second volume was released, with four copperplates. In his 'Autobiography', von Baer did not clarify the reasons why he did not finish his research program of comparative embryology. The paper attempts to elucidate them, furnished by archival documents and von Baer's unpublished embryological drawings. Our sketch of a few figures will show that (1) von Baer searched for 'analogies' (homologies) as a unifying principle and (2) explained the mechanisms of embryogenesis by physiological reasoning (electromagnetism). The main objective is to show that technical problems in illustrating and conceptual difficulties impeded von Baer's ambitious research program. PMID:16302690

  17. von Baer's law for the ages: lost and found principles of developmental evolution.

    PubMed

    Abzhanov, Arhat

    2013-12-01

    In 1828, Karl Ernst von Baer formulated a series of empirically defined rules, which became widely known as the 'Law of Development' or 'von Baer's law of embryology'. This was one the most significant attempts to define the principles that connected morphological complexity and embryonic development. Understanding this relation is central to both evolutionary biology and developmental genetics. Von Baer's ideas have been both a source of inspiration to generations of biologists and a target of continuous criticism over many years. With advances in multiple fields, including paleontology, cladistics, phylogenetics, genomics, and cell and developmental biology, it is now possible to examine carefully the significance of von Baer's law and its predictions. In this review, I argue that, 185 years after von Baer's law was first formulated, its main concepts after proper refurbishing remain surprisingly relevant in revealing the fundamentals of the evolution-development connection, and suggest that their explanation should become the focus of renewed research. PMID:24120296

  18. Karl ernst von Baer's 'Uber Entwickelungsgeschichte der Thiere II' and its unpublished drawings.

    PubMed

    Tammiksaar, Erki; Brauckmann, Sabine

    2004-01-01

    In 1828 Karl Ernst von Baer (1792-1876) published his seminal Uber Entwickelungsgeschichte der Thiere. Beobachtung und Reflexion. In the preface he announced that a second volume with one copper plate would be finished 'in a few weeks'. However, it took nine years until the unfinished second volume was released, with four copperplates. In his 'Autobiography', von Baer did not clarify the reasons why he did not finish his research program of comparative embryology. The paper attempts to elucidate them, furnished by archival documents and von Baer's unpublished embryological drawings. Our sketch of a few figures will show that (1) von Baer searched for 'analogies' (homologies) as a unifying principle and (2) explained the mechanisms of embryogenesis by physiological reasoning (electromagnetism). The main objective is to show that technical problems in illustrating and conceptual difficulties impeded von Baer's ambitious research program.

  19. von Baer's law for the ages: lost and found principles of developmental evolution.

    PubMed

    Abzhanov, Arhat

    2013-12-01

    In 1828, Karl Ernst von Baer formulated a series of empirically defined rules, which became widely known as the 'Law of Development' or 'von Baer's law of embryology'. This was one the most significant attempts to define the principles that connected morphological complexity and embryonic development. Understanding this relation is central to both evolutionary biology and developmental genetics. Von Baer's ideas have been both a source of inspiration to generations of biologists and a target of continuous criticism over many years. With advances in multiple fields, including paleontology, cladistics, phylogenetics, genomics, and cell and developmental biology, it is now possible to examine carefully the significance of von Baer's law and its predictions. In this review, I argue that, 185 years after von Baer's law was first formulated, its main concepts after proper refurbishing remain surprisingly relevant in revealing the fundamentals of the evolution-development connection, and suggest that their explanation should become the focus of renewed research.

  20. Klassifikation von Standardebenen in der 2D-Echokardiographie mittels 2D-3D-Bildregistrierung

    NASA Astrophysics Data System (ADS)

    Bergmeir, Christoph; Subramanian, Navneeth

    Zum Zweck der Entwicklung eines Systems, das einen unerfahrenen Anwender von Ultraschall (US) zur Aufnahme relevanter anatomischer Strukturen leitet, untersuchen wir die Machbarkeit von 2D-US zu 3D-CT Registrierung. Wir verwenden US-Aufnahmen von Standardebenen des Herzens, welche zu einem 3D-CT-Modell registriert werden. Unser Algorithmus unterzieht sowohl die US-Bilder als auch den CT-Datensatz Vorverarbeitungsschritten, welche die Daten durch Segmentierung auf wesentliche Informationen in Form von Labein für Muskel und Blut reduzieren. Anschließend werden diese Label zur Registrierung mittels der Match-Cardinality-Metrik genutzt. Durch mehrmaliges Registrieren mit verschiedenen Initialisierungen ermitteln wir die im US-Bild sichtbare Standardebene. Wir evaluierten die Methode auf sieben US-Bildern von Standardebenen. Fünf davon wurden korrekt zugeordnet.

  1. Comparison between von Willebrand factor (VWF) and VWF antigen II in normal individuals and patients with von Willebrand disease.

    PubMed

    de Romeuf, C; Mazurier, C

    1998-07-01

    Von Willebrand disease is characterised by a quantitative (type 1) or qualitative (type 2) decrease in von Willebrand factor (vWF) a multimeric glycoprotein involved in primary haemostasis. The propeptide of von Willebrand, also named vWF antigen II (vWF:AgII), is released from platelets and endothelial cells and circulates in plasma as a glycoprotein of 100 kD. In the present study, we attempted to determine whether vWF:AgII level may provide information on the synthesis of vWF, specially in patients with von Willebrand disease (vWD). To elucidate that point, we developed an ELISA and quantify the vWF:AgII in normal individuals and in various vWD patients. The propeptide molar concentration was found to be 5 nM as compared to 31 nM for mature vWF. In normal individuals, the level of vWF:AgII was significantly decreased in females from O and A blood groups. In type 2 vWD patients the level of plasma vWF:AgII appears normal in the patients with normal level of platelet vWF. In type 2 B vWD characterised by increased affinity of mature vWF for platelet glycoprotein Ib, the vWF:AgII in contrast to the vWF antigen (vWF:Ag) was not decreased. In type 2A vWD patients the level of vWF:AgII was decreased in patients with absence of high molecular weight vWF in platelets and plasma but normal in patients with increased sensitivity to proteolysis. Finally, in type 1 vWD, some studied patients have a parallel decrease in vWF:AgII and vWF:Ag whereas in others, the vWF:Ag levels were much more affected than corresponding vWF:AgII levels, as observed in some type 2 vWD patients. Thus, in contrast to that already described, the plasma vWF:AgII level cannot discriminate type 1 from type 2 vWD patients. We conclude that the vWF:AgII measurement provides additional information on the mechanisms responsible for vWD and might also contribute to the classification of vWD patients. PMID:9684782

  2. Sexual Modernity in the Works of Richard von Krafft-Ebing and Albert Moll

    PubMed Central

    Oosterhuis, Harry

    2012-01-01

    The modern notion of sexuality took shape at the end of the nineteenth century, especially in the works of Richard von Krafft-Ebing and Albert Moll. This modernisation of sexuality was closely linked to the recognition of sexual diversity, as it was articulated in the medical–psychiatric understanding of what, at that time, was labelled as perversion. From around 1870, psychiatrists shifted the focus from immoral acts, a temporary deviation of the norm, to an innate morbid condition. In the late nineteenth century, several psychiatrists, collecting and publishing more and more case histories, classified and explained the wide range of deviant sexual behaviours they traced. The emergence of medical sexology meant that perversions could be diagnosed and discussed. Against this background both Krafft-Ebing and Moll articulated a new perspective, not only on perversion, but also on sexuality in general. Krafft-Ebing initiated and Moll elaborated a shift from a psychiatric perspective in which deviant sexuality was explained as a derived, episodic and more or less singular symptom of a more fundamental mental disorder, to a consideration of perversion as an integral part of a more general, autonomous and continuous sexual instinct. Before Sigmund Freud and others had expressed similar views, it was primarily through the writings of Krafft-Ebing and Moll that a new understanding of human sexuality emerged. PMID:23002290

  3. Dynamical Correspondence in a Generalized Quantum Theory

    NASA Astrophysics Data System (ADS)

    Niestegge, Gerd

    2015-05-01

    In order to figure out why quantum physics needs the complex Hilbert space, many attempts have been made to distinguish the C*-algebras and von Neumann algebras in more general classes of abstractly defined Jordan algebras (JB- and JBW-algebras). One particularly important distinguishing property was identified by Alfsen and Shultz and is the existence of a dynamical correspondence. It reproduces the dual role of the selfadjoint operators as observables and generators of dynamical groups in quantum mechanics. In the paper, this concept is extended to another class of nonassociative algebras, arising from recent studies of the quantum logics with a conditional probability calculus and particularly of those that rule out third-order interference. The conditional probability calculus is a mathematical model of the Lüders-von Neumann quantum measurement process, and third-order interference is a property of the conditional probabilities which was discovered by Sorkin (Mod Phys Lett A 9:3119-3127, 1994) and which is ruled out by quantum mechanics. It is shown then that the postulates that a dynamical correspondence exists and that the square of any algebra element is positive still characterize, in the class considered, those algebras that emerge from the selfadjoint parts of C*-algebras equipped with the Jordan product. Within this class, the two postulates thus result in ordinary quantum mechanics using the complex Hilbert space or, vice versa, a genuine generalization of quantum theory must omit at least one of them.

  4. Von Braun Rocket Team at Fort Bliss, Texas

    NASA Technical Reports Server (NTRS)

    1940-01-01

    The German Rocket Team, also known as the Von Braun Rocket Team, poses for a group photograph at Fort Bliss, Texas. After World War II ended in 1945, Dr. Wernher von Braun led some 120 of his Peenemuende Colleagues, who developed the V-2 rocket for the German military during the War, to the United Sttes under a contract to the U.S. Army Corps as part of Operation Paperclip. During the following five years the team worked on high altitude firings of the captured V-2 rockets at the White Sands Missile Range in New Mexico, and a guided missile development unit at Fort Bliss, Texas. In April 1950, the group was transferred to the Army Ballistic Missile Agency (ABMA) at Redstone Arsenal in Huntsville, Alabama, and continued to work on the development of the guided missiles for the U.S. Army until transferring to a newly established field center of the National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC).

  5. Acquired von Willebrand syndrome associated with left ventricular assist device.

    PubMed

    Nascimbene, Angelo; Neelamegham, Sriram; Frazier, O H; Moake, Joel L; Dong, Jing-Fei

    2016-06-23

    Left ventricular assist devices (LVAD) provide cardiac support for patients with end-stage heart disease as either bridge or destination therapy, and have significantly improved the survival of these patients. Whereas earlier models were designed to mimic the human heart by producing a pulsatile flow in parallel with the patient's heart, newer devices, which are smaller and more durable, provide continuous blood flow along an axial path using an internal rotor in the blood. However, device-related hemostatic complications remain common and have negatively affected patients' recovery and quality of life. In most patients, the von Willebrand factor (VWF) rapidly loses large multimers and binds poorly to platelets and subendothelial collagen upon LVAD implantation, leading to the term acquired von Willebrand syndrome (AVWS). These changes in VWF structure and adhesive activity recover quickly upon LVAD explantation and are not observed in patients with heart transplant. The VWF defects are believed to be caused by excessive cleavage of large VWF multimers by the metalloprotease ADAMTS-13 in an LVAD-driven circulation. However, evidence that this mechanism could be the primary cause for the loss of large VWF multimers and LVAD-associated bleeding remains circumstantial. This review discusses changes in VWF reactivity found in patients on LVAD support. It specifically focuses on impacts of LVAD-related mechanical stress on VWF structural stability and adhesive reactivity in exploring multiple causes of AVWS and LVAD-associated hemostatic complications. PMID:27143258

  6. A visit paid to Jung by Alwine von Keller.

    PubMed

    Bernardini, Riccardo; Quaglino, Gian Piero; Romano, Augusto

    2011-04-01

    In the winter of 1943-1944, Jung had suffered a coronary thrombosis which almost cost him his life. During his illness, Jung experienced a series of visions, described in his Memories, Dreams, Reflections, which were also to influence significantly the development of his theoretical thinking. On 27(th) September 1944, Alwine von Keller (1878-1965) paid a visit to Jung, while he was still convalescing, in Zurich and documented her meeting with him in a series of notes, recently discovered, which testify to the fact that, at the time of their meeting, Jung was engaged in writing the 'Salt' chapter of Mysterium coniunctionis and investigating the alchemistic symbolism of the 'sea'. This theme seems to testify to a continuity of interests on Jung's part with the seminar he held at Eranos the previous year on the cartographic art of Opicinus de Canistris (1296-c.1352). With its addition of many unpublished details, Alwine von Keller's notes supplement the report which Jung made of his visions experienced during his sickness in MDR. In particular, these attest to the fact that Jung had attributed the terrible experience which he had endured to the problem of the conjunctio, which was confronting him from the theoretical point of view in his writing of Mysterium coniunctionis.

  7. Attractors and Long Time Behavior of von Karman Thermoelastic Plates

    SciTech Connect

    Chueshov, Igor Lasiecka, Irena

    2008-10-15

    This paper undertakes a study of asymptotic behavior of solutions corresponding to von Karman thermoelastic plates. A distinct feature of the work is that the model considered has no added dissipation-particularly mechanical dissipation typically added to plate equation when long time-behavior is considered. Thus, the model consists of undamped oscillatory plate equation strongly coupled with heat equation. Nevertheless we are able to show that the ultimate (asymptotic) behavior of the von Karman evolution is described by finite dimensional global attractor. In addition, the obtained estimate for the dimension and the size of the attractor are independent of the rotational inertia parameter {gamma} and heat/thermal capacity {kappa}, where the former is known to change the character of dynamics from hyperbolic ({gamma}>0) to parabolic like ({gamma}=0). Other properties of attractors such as additional smoothness and upper-semicontinuity with respect to parameters {gamma} and {kappa} are also established. The main ingredients of the proofs are (i) sharp regularity of Airy's stress function, and (ii) newly developed (Chueshov and Lasiecka in Memoirs of AMS, in press) 'compensated' compactness methods applicable to non-compact dynamics.

  8. Superfluid high REynolds von Kármán experiment.

    PubMed

    Rousset, B; Bonnay, P; Diribarne, P; Girard, A; Poncet, J M; Herbert, E; Salort, J; Baudet, C; Castaing, B; Chevillard, L; Daviaud, F; Dubrulle, B; Gagne, Y; Gibert, M; Hébral, B; Lehner, Th; Roche, P-E; Saint-Michel, B; Bon Mardion, M

    2014-10-01

    The Superfluid High REynolds von Kármán experiment facility exploits the capacities of a high cooling power refrigerator (400 W at 1.8 K) for a large dimension von Kármán flow (inner diameter 0.78 m), which can work with gaseous or subcooled liquid (He-I or He-II) from room temperature down to 1.6 K. The flow is produced between two counter-rotating or co-rotating disks. The large size of the experiment allows exploration of ultra high Reynolds numbers based on Taylor microscale and rms velocity [S. B. Pope, Turbulent Flows (Cambridge University Press, 2000)] (Rλ > 10000) or resolution of the dissipative scale for lower Re. This article presents the design and first performance of this apparatus. Measurements carried out in the first runs of the facility address the global flow behavior: calorimetric measurement of the dissipation, torque and velocity measurements on the two turbines. Moreover first local measurements (micro-Pitot, hot wire,…) have been installed and are presented. PMID:25362417

  9. Renaturierung von Ökosystemen in urban-industriellen Landschaften

    NASA Astrophysics Data System (ADS)

    Rebele, Franz

    Die Urbanisierung ist ein weltweit stattfindender Prozess mit weitreichenden Auswirkungen auf Mensch und Natur. In Mitteleuropa leben heute etwa 80% aller Bewohner in Städten. Urban-industrielle Landschaften gehören deshalb zur unmittelbaren Lebensumwelt der meisten Menschen. Allein in Deutschland wird heute täglich eine Fläche von 120 ha neu für Siedlungs- und Verkehrszwecke in Anspruch genommen. Zu den Siedlungs- und Verkehrsflächen zählen Gebäude-und gebäudebezogene Freiflächen, Verkehrsflächen, Erholungsflächen und Friedhöfe sowie Betriebsflächen für Industrie und Gewerbe. Nicht enthalten sind Tagebauflächen zum Abbau von Bodenschätzen (Kapitel 13). In Deutschland liegt der Anteil der Siedlungs- und Verkehrsflächen an der Gesamtfläche derzeit bei ca. 13%, in Österreich bei 5 % und in der Schweiz bei knapp 7 %. Charakteristisch für die heutige Entwicklung in Mitteleuropa ist, dass die Prozesse der Urbanisierung und der Flächeninanspruchnahme für Siedlung und Verkehr nicht ursächlich mit einem Bevölkerungswachstum verbunden sind, d. h. dass Freiflächen auch bei stagnierender oder in manchen Regionen sogar bei sinkender Einwohnerzahl bebaut werden.

  10. von Willebrand factor, Jedi knight of the bloodstream.

    PubMed

    Springer, Timothy A

    2014-08-28

    When blood vessels are cut, the forces in the bloodstream increase and change character. The dark side of these forces causes hemorrhage and death. However, von Willebrand factor (VWF), with help from our circulatory system and platelets, harnesses the same forces to form a hemostatic plug. Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use "the Force" to do good, VWF may be considered the Jedi knight of the bloodstream. The long length of VWF enables responsiveness to flow. The shape of VWF is predicted to alter from irregularly coiled to extended thread-like in the transition from shear to elongational flow at sites of hemostasis and thrombosis. Elongational force propagated through the length of VWF in its thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and likely also increases affinity of the A1 domain for platelets. Specialized domains concatenate and compact VWF during biosynthesis. A2 domain unfolding by hydrodynamic force enables postsecretion regulation of VWF length. Mutations in VWF in von Willebrand disease contribute to and are illuminated by VWF biology. I attempt to integrate classic studies on the physiology of hemostatic plug formation into modern molecular understanding, and point out what remains to be learned.

  11. Contemporary issues in the management of von Willebrand disease.

    PubMed

    Federici, Augusto B; Königs, Christoph; James, Andra H

    2016-08-31

    Von Willebrand disease (VWD) is the most common inherited bleeding disorder. Bleeding scores in VWD, focused in particular on mucosal bleeding, can be very useful in the diagnosis and validation of different types of treatment. The results of an extended prospective study with a large amount of information on clinical phenotype and implications in treatment are reviewed in this article. Treatment of mucosal and joint bleeding in severe VWD remains difficult in some patients. Due to the lack of data on the use of prophylaxis in these patients it is difficult to establish optimal treatment regimens. An overview of the literature, with a focus on the ongoing PRO.WILL study, is provided here. Furthermore, understanding the changes in von Willebrand factor (VWF) levels during pregnancy is very important for establishing the optimal management strategy for pregnancy and delivery in women with VWD. A recently published prospective observational cohort study in women with and without VWD during the postpartum period provides important data that should allow the improvement of postpartum treatment protocols.

  12. Superfluid high REynolds von Kármán experiment

    NASA Astrophysics Data System (ADS)

    Rousset, B.; Bonnay, P.; Diribarne, P.; Girard, A.; Poncet, J. M.; Herbert, E.; Salort, J.; Baudet, C.; Castaing, B.; Chevillard, L.; Daviaud, F.; Dubrulle, B.; Gagne, Y.; Gibert, M.; Hébral, B.; Lehner, Th.; Roche, P.-E.; Saint-Michel, B.; Bon Mardion, M.

    2014-10-01

    The Superfluid High REynolds von Kármán experiment facility exploits the capacities of a high cooling power refrigerator (400 W at 1.8 K) for a large dimension von Kármán flow (inner diameter 0.78 m), which can work with gaseous or subcooled liquid (He-I or He-II) from room temperature down to 1.6 K. The flow is produced between two counter-rotating or co-rotating disks. The large size of the experiment allows exploration of ultra high Reynolds numbers based on Taylor microscale and rms velocity [S. B. Pope, Turbulent Flows (Cambridge University Press, 2000)] (Rλ > 10000) or resolution of the dissipative scale for lower Re. This article presents the design and first performance of this apparatus. Measurements carried out in the first runs of the facility address the global flow behavior: calorimetric measurement of the dissipation, torque and velocity measurements on the two turbines. Moreover first local measurements (micro-Pitot, hot wire,…) have been installed and are presented.

  13. Mutations in the D1 domain of von Willebrand factor impair their propeptide-dependent multimerization, intracellular trafficking and secretion.

    PubMed

    Yin, Jie; Ma, Zhenni; Su, Jian; Wang, Jiong-Wei; Zhao, Xiaojuan; Ling, Jing; Bai, Xia; Ouyang, Wanyan; Wang, Zhaoyue; Yu, Ziqiang; Ruan, Changgeng

    2015-01-01

    We identified three novel mutations (p.Gly39Arg, p.Lys157Glu, p.Cys379Gly) and one previously known mutation (p.Asp141Asn) in the von Willebrand factor propeptide from three von Willebrand disease patients. All four mutations impaired multimerization of von Willebrand factor, due to reduced oxidoreductase activity of isomeric propeptide. These mutations resulted in the endothelial reticulum retention and impaired basal and stimulated secretions of von Willebrand factor. Our results support that the mutations in the D1 domain lead to defective multimerization, intracellular trafficking, and secretion of von Willebrand factor and result in bleeding of patients. PMID:26088471

  14. Utility of a Pediatric Bleeding Questionnaire as a Screening Tool for von Willebrand Disease in Apparently Healthy Children

    PubMed Central

    Mittal, Nupur; Pedersen, Rachelle; James, Paula; Shott, Susan; Valentino, Leonard A.

    2015-01-01

    von Willebrand disease (VWD), an inherited bleeding disorder caused by deficiency or dysfunction of von Willebrand factor (VWF) is diagnosed when a personal and often a family history of excessive mucocutaneous bleeding is present along with abnormal laboratory studies. An accurate assessment of hemorrhagic symptoms is key in suspecting VWD but presents a challenge especially in children due to overlap between normal and abnormal bleeding. Bleeding questionnaire (BQ) scores have been validated in adults and have recently been validated in children with VWD for assessing bleeding severity. However there is limited data supporting their use prospectively in healthy children with bleeding complaints. The objectives of this study were to obtain normative data from children and validate a pediatric BQ to determine the discriminative ability of its total score and its individual components for identifying children likely to have VWD. Methods The pediatric BQ was administered to 1281 multiethnic, healthy children between 30 days and 18 years of age presenting to a general pediatric office and to 35 children with VWD based on VWF antigen, activity and multimer pattern. Results When children with total BQ scores of 3 or more were predicted to have VWD, the sensitivity was 97.2%, the specificity was 97.1%, the positive predictive value was 48.6%, and the negative predictive value was 99.9%. Conclusions The pediatric BQ may help discriminate a significant bleeding history from otherwise trivial bleeding and may be integrated into the primary care algorithm for evaluating children suspected of having VWD. PMID:25982122

  15. Stochastic wave packet vs. direct density matrix solution of Liouville-von Neumann equations for photodesorption problems

    NASA Astrophysics Data System (ADS)

    Saalfrank, Peter

    1996-11-01

    The performance of stochastic wave packet approaches is contrasted with a direct method to numerically solve quantum open system Liouville-von Neumann equations for photodesorption problems. As a test case a simple one-dimensional two-state state model representative for NO/Pt(111) is adopted. Both desorption induced by electronic transitions (DIET) treated by a single-dissipative channel model, and desorption induced by multiple electronic transitions (DIMET) treated by a double-dissipative channel model, are considered. It is found that stochastic wave packets are a memory-saving alternative to direct matrix propagation schemes. However, if statistically rare events as for example the bond breaking in NO/Pt(111) are of interest, the former converges only slowly to the exact results. We also find that - in the case of coordinate-independent rates - Gadzuk's "jumping wave packet and weighted average" procedure frequently employed to describe DIET dynamics, is a rapidly converging variant of the stochastic wave packet approach, and therefore rigorously equivalent to the exact solution of a Liouville-von Neumann equation. The usual stochastic (Monte Carlo) wave packet approach, however, is more generally applicable, and allows for example to quantify the notion of "multiple" in DIMET processes.

  16. Successful use of acitretin in conjunction with narrowband ultraviolet B phototherapy in a child with severe pustular psoriasis, von Zumbusch type.

    PubMed

    Kopp, T; Karlhofer, F; Szépfalusi, Z; Schneeberger, A; Stingl, G; Tanew, A

    2004-10-01

    Severe pustular psoriasis von Zumbusch type is a therapeutic challenge not only in adults, but even more in children. We report a 3(1/2)-year-old boy who developed a generalized flare of diffusely scattered pustules on erythematous skin which rapidly progressed to large exuding areas. The clinical presentation and investigations including histopathological examination of a biopsy and negative bacterial cultures were consistent with the diagnosis of pustular psoriasis von Zumbusch type. Upon initial treatment with methylprednisolone, acitretin and antibiotics the extent of the disease declined. However, several attempts to reduce the dose of the oral corticosteroid were followed by immediate severe flares. Additional treatment with narrowband ultraviolet B (NB-UVB, 311-313 nm UVB) resulted in a rapid arrest of disease activity and allowed the corticosteroid to be tapered off. After 10 irradiations the patient was both off steroid and disease free. NB-UVB therapy was subsequently reduced to twice-weekly exposures and acitretin gradually diminished to a maintenance dose of 0.3 mg kg(-1) daily. We conclude that NB-UVB in conjunction with acitretin is a potent therapeutic regimen for the treatment of severe pustular psoriasis von Zumbusch type in childhood. PMID:15491438

  17. [Structure and function of the factor VIII/von Willebrand factor complex].

    PubMed

    Müller, G

    1990-03-01

    In the blood plasma factor VIII is bound to the von Willebrand factor. The primary structure of the two proteins were clarified by gene clonation. Factor VIII descends from a precursor protein with 2,351 amino acids by splitting of 19 amino acid residues and is activated by partial proteolysis. In the blood coagulation factor VIII acts as co-factor for the activation of factor X by factor IX in the presence of phospholipids and Ca++ within the intrinsic coagulation system. The formation of the von Willebrand factor takes place by splitting of 22 and 741 amino acid residues, respectively, from pre-pro-von Willebrand factor via pro-von Willebrand factor. The subunits of the von Willebrand factor consist od 2,050 amino acid residues. In the blood plasma the von Willebrand factor is existing as a mixture of multimeres. Receptors of the von Willebrand factor on the thrombocytic membrane are the glycoproteins GPIb and GPIIb/GPIIIa, by means of which the adhesion of thrombocytes at the subendoethelium of the vascular wall and the aggregation of thrombocytes are mediated. PMID:2159676

  18. General uncertainty.

    PubMed

    Moore, Alison

    Many district general hospitals are likely to lose services, and some may close, as a result of the pressure to centralise specialist services, improve patient outcomes and cope with funding cuts. Nurses are increasingly willing to support intelligent reconfiguration if it will improve patient care, but changes in acute services have to be supported by improvements in the community.

  19. Generalized Parabolas

    ERIC Educational Resources Information Center

    Joseph, Dan; Hartman, Gregory; Gibson, Caleb

    2011-01-01

    In this article we explore the consequences of modifying the common definition of a parabola by considering the locus of all points equidistant from a focus and (not necessarily linear) directrix. The resulting derived curves, which we call "generalized parabolas," are often quite beautiful and possess many interesting properties. We show that…

  20. Generalized transduction.

    PubMed

    Thierauf, Anne; Perez, Gerardo; Maloy, And Stanley

    2009-01-01

    Transduction is the process in which bacterial DNA is transferred from one bacterial cell to another by means of a phage particle. There are two types of transduction, generalized transduction and specialized transduction. In this chapter two of the best-studied systems - Escherichia coli-phage P1, and Salmonella enterica-phage P22 - are discussed from theoretical and practical perspectives.

  1. von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.

    PubMed

    Sorvillo, Nicoletta; Hartholt, Robin B; Bloem, Esther; Sedek, Magdalena; ten Brinke, Anja; van der Zwaan, Carmen; van Alphen, Floris P; Meijer, Alexander B; Voorberg, Jan

    2016-03-01

    It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived dendritic cells using flow cytometry and confocal microscopy. Surprisingly, von Willebrand factor was not internalized by immature dendritic cells, but remained bound to the cell surface. As von Willebrand factor reduces the uptake of factor VIII, we investigated the repertoire of factor VIII presented peptides when in complex with von Willebrand factor. Interestingly, factor VIII-derived peptides were still abundantly presented on major histocompatibility complex class II molecules, even though a reduction of factor VIII uptake by immature dendritic cells was observed. Inspection of peptide profiles from 5 different donors showed that different core factor VIII peptide sequences were presented upon incubation with factor VIII/von Willebrand factor complex when compared to factor VIII alone. No von Willebrand factor peptides were detected when immature dendritic cells were pulsed with different concentrations of von Willebrand factor, confirming lack of von Willebrand factor endocytosis. Several von Willebrand factor derived peptides were recovered when cells were pulsed with von Willebrand factor/factor VIII complex, suggesting that factor VIII promotes endocytosis of small amounts of von Willebrand factor by immature dendritic cells. Taken together, our results establish that von Willebrand factor is poorly internalized by immature dendritic cells. We also show that von Willebrand factor modulates the internalization and presentation of factor VIII-derived peptides on major histocompatibility complex class II. PMID:26635035

  2. von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII

    PubMed Central

    Sorvillo, Nicoletta; Hartholt, Robin B.; Bloem, Esther; Sedek, Magdalena; Brinke, Anja ten; van der Zwaan, Carmen; van Alphen, Floris P.; Meijer, Alexander B.; Voorberg, Jan

    2016-01-01

    It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived dendritic cells using flow cytometry and confocal microscopy. Surprisingly, von Willebrand factor was not internalized by immature dendritic cells, but remained bound to the cell surface. As von Willebrand factor reduces the uptake of factor VIII, we investigated the repertoire of factor VIII presented peptides when in complex with von Willebrand factor. Interestingly, factor VIII-derived peptides were still abundantly presented on major histocompatibility complex class II molecules, even though a reduction of factor VIII uptake by immature dendritic cells was observed. Inspection of peptide profiles from 5 different donors showed that different core factor VIII peptide sequences were presented upon incubation with factor VIII/von Willebrand factor complex when compared to factor VIII alone. No von Willebrand factor peptides were detected when immature dendritic cells were pulsed with different concentrations of von Willebrand factor, confirming lack of von Willebrand factor endocytosis. Several von Willebrand factor derived peptides were recovered when cells were pulsed with von Willebrand factor/factor VIII complex, suggesting that factor VIII promotes endocytosis of small amounts of von Willebrand factor by immature dendritic cells. Taken together, our results establish that von Willebrand factor is poorly internalized by immature dendritic cells. We also show that von Willebrand factor modulates the internalization and presentation of factor VIII-derived peptides on major histocompatibility complex class II. PMID:26635035

  3. Ein stochastisches Modell zur Beschreibung von Signalen in digitalen Schaltungen basierend auf quadratischer Optimierung

    NASA Astrophysics Data System (ADS)

    Kleeberger, V. B.; Maier, P.; Schlichtmann, U.

    2013-07-01

    Die kontinuierlich fortschreitende Miniaturisierung in integrierten Schaltungen führt zu einem erhöhten Modellierungsbedarf verschiedenster Effekte, wie z.B. Alterung oder Stromverbrauch. Diese hängen von den auftretenden Signalen innerhalb der Schaltung ab, wodurch deren statistische Modellierung ein zentrales Problem darstellt. Dieser Beitrag stellt eine neue Methode zur stochastischen Signalmodellierung basierend auf quadratischer Optimierung vor. Die Methode wird mit Hilfe von realen Daten mit existierenden Ansätzen verglichen. Die Testergebnisse zeigen hierbei im vorgestellten Modell einen Genauigkeitszuwachs von bis zu einem Faktor 10 im Vergleich zu bereits existierenden Modellen.

  4. [Scientific theoretical founding of medicine as a natural science by Hermann von Helmholtz (1821-1894)].

    PubMed

    Neumann, J N

    1994-01-01

    In this study an attempt will be made to discuss the epistemological problems in the theory and practice of modern technical medicine in the writings of Hermann von Helmholz. An inquiry into the relationship between von Helmholtz' thinking and the critical philosophy of Immanuel Kant is followed by the characteristics of von Helmholtz' philosophy of science which he himself called "empirical theory". The question of medicine as a science finally leads to the main problem of medical epistemology, viz., the relationship between theoretical knowledge and practice in medicine. In this context the anthropological dimension is brought into consideration.

  5. [Ernst von der Porten : looking for facts before and after forced emigration].

    PubMed

    Goerig, M; Bruijn, L

    2014-10-01

    The Ernst von der Porten medal has been awarded for many years to exceptional personalities by the Alliance of German Anesthesiologists to honor the outstanding achievements of the physician Ernst von der Porten from Hamburg in the development of anesthesiology as an autonomous discipline Only recent access to hitherto inaccessible documents enabled the reconstruction of his final years. He was persecuted and excluded by the National Socialist (NS) regime due to his Jewish roots and finally forced to emigrate. Records revealed that even in the so-called safe exile, degrading treatment and humiliation continued for Ernst von der Porten and his family. He eventually evaded this situation by committing suicide.

  6. Two different anesthetic managements of a patient with von Gierke's disease.

    PubMed

    Huang, I-Ren; Jean, Wei-Horng; Lu, Cheng-Wei; Wu, Chia-Chan; Lin, Tzu-Yu; Chuang, Yueh-Hsun; Sun, Wei-Zen

    2006-03-01

    Von Gierke's disease, a form of glycogen storage disturbance, is a rare metabolic disorder with important implications for anesthesiologists. It is caused by the lack of the glucose-6-phosphatase, which is necessary for the liver to convert glycogen to glucose. To avoid severe hypoglycemia, it is crucial to keep oral feeding at intervals 2-3 hr for maintaining a normal blood sugar level. The metabolic derangements of von Gierke's disease may result in serious complications in patients undergoing surgery and anesthesia. We report the anesthetic managements of a patient with von Gierke's disease in two operations with different encounters. PMID:16623410

  7. On conjugate families and Jeffreys priors for von Mises–Fisher distributions

    PubMed Central

    Hornik, Kurt; Grün, Bettina

    2013-01-01

    This paper discusses characteristics of standard conjugate priors and their induced posteriors in Bayesian inference for von Mises–Fisher distributions, using either the canonical natural exponential family or the more commonly employed polar coordinate parameterizations. We analyze when standard conjugate priors as well as posteriors are proper, and investigate the Jeffreys prior for the von Mises–Fisher family. Finally, we characterize the proper distributions in the standard conjugate family of the (matrix-valued) von Mises–Fisher distributions on Stiefel manifolds. PMID:23805026

  8. [General psychotherapy].

    PubMed

    Vymetal, J

    2003-01-01

    Nowadays a theoretical psychotherapeutical thinking develops from the eclectic practice and uses particularly the research of the effective factors of the therapy. Best they can be characterized as differentiate, synthetic, integrative and exceeding other approaches. The development in question goes on with attempts of creating a general model of the psychotherapy that could be a basis for models of special psychotherapies. The aim of such a model is to describe all that is present as important factor for inducing a desirable change of a human in all psychotherapeutical approaches. Among general models we can mention the generic model of D. E. Orlinski and K. I. Howard, Grawe's cube (the author is K. Grawe) and the equation of the psychotherapy.

  9. Generalized Myoclonus

    PubMed Central

    McCullough, Louise D.

    2015-01-01

    Movement disorders have been reported as rare complications of stroke. The basal ganglia have been implicated in the pathophysiology of most post-stroke dyskinesias. We outline different types of post-stroke myoclonus and their possible pathophysiology. A middle-aged man developed generalized myoclonus after an ischemic stroke in the superior midbrain and subthalamic nuclei. Spontaneous resolution was seen by 72 hours. A lesion to the subthalamic nuclei disrupted the normal thalamic inhibition, which likely led to the involuntary movements seen in our patient. In this case, myoclonus was generalized, which, to the best of our knowledge, has not been reported in the literature as a direct consequence of focal stroke. PMID:25553226

  10. Temporal generalization.

    PubMed

    Church, R M; Gibbon, J

    1982-04-01

    Responses of 26 rats were reinforced following a signal of a certain duration, but not following signals of shorter or longer durations. This led to a positive temporal generalization gradient with a maximum at the reinforced duration in six experiments. Spacing of the nonreinforced signals did not influence the gradient, but the location of the maximum and breadth of the gradient increased with the duration of the reinforced signal. Reduction of reinforcement, either by partial reinforcement or reduction in the probability of a positive signal, led to a decrease in the height of the generalization gradient. There were large, reliable individual differences in the height and breadth of the generalization gradient. When the conditions of reinforcement were reversed (responses reinforced following all signals longer or shorter than a single nonreinforced duration), eight additional rats had a negative generalization gradient with a minimum at a signal duration shorter than the single nonreinforced duration. A scalar timing theory is described that provided a quantitative fit of the data. This theory involved a clock that times in linear units with an accurate mean and a negligible variance, a distribution of memory times that is normally distributed with an accurate mean and a scalar standard deviation, and a rule to respond if the clock is "close enough" to a sample of the memory time distribution. This decision is based on a ratio of the discrepancy between the clock time and the remembered time, to the remembered time. When this ratio is below a (variable) threshold, subjects respond. When three timing parameters--coefficient of variation of the memory time, the mean and the standard deviation of the threshold--were set at their median values, a theory with two free parameters accounted for 96% of the variance. The two parameters reflect the probability of attention to time and the probability of a response given inattention. These parameters were not influenced

  11. The von Restorff effect in rats (Rattus norvegicus).

    PubMed

    Reed, P; Richards, A

    1996-06-01

    Two experiments examined the functional equivalence of memory in the rat (Rattus norvegicus) with memory in humans for serially presented items. Memory was assayed with an 8-arm radial maze, in which rats were allowed access to 5 arms of the maze and were then removed. Following a retention interval of 16 min, the rats were replaced in the maze and allowed to retrieve pellets from the 3 unvisited arms. The errors in reentering previously visited arms were noted. Both primacy and recency effects were found as with humans. Presenting a stimulus change after entry to 1 of the maze arms improved recall for that arm relative to when no change occurred. This effect was found using both handling and tone cues, and irrespective of whether the change consisted of presentation or nonpresentation of the cue. These results suggest that rats are subject to a von Restorff-like effect similar to that in humans.

  12. A Powerful Friendship: Theodore von Karman and Hugh L. Dryden

    NASA Technical Reports Server (NTRS)

    Gorn, Michael

    2003-01-01

    During their long personal friendship and professional association, Theodore von Karman (1882-1963) and Hugh L. Dryden (1898-1965) exercised a pivotal if somewhat elusive influence over American aeronautics and spaceflight. Both decisive figures in organizing scientists and engineers at home and abroad, both men of undisputed eminence in their technical fields, their range of contacts in government, academia, the armed forces, industry, and professional societies spanned the globe to an extent unparalleled then as now. Moreover, because they coordinated their activities closely, their combined influence far exceeded the sum of each one s individual contributions. This paper illustrates their personal origins as well as the foundations of their friendship, how their relationship became a professional alliance, and their joint impact on the world of aeronautics and astronautics during the twentieth century.

  13. Voluntarism in early psychology: the case of Hermann von Helmholtz.

    PubMed

    De Kock, Liesbet

    2014-05-01

    The failure to recognize the programmatic similarity between (post-)Kantian German philosophy and early psychology has impoverished psychology's historical self-understanding to a great extent. This article aims to contribute to recent efforts to overcome the gaps in the historiography of contemporary psychology, which are the result of an empiricist bias. To this end, we present an analysis of the way in which Hermann von Helmholtz's theory of perception resonates with Johann Gottlieb Fichte's Ego-doctrine. It will be argued that this indebtedness is particularly clear when focusing on the foundation of the differential awareness of subject and object in perception. In doing so, the widespread reception of Helmholtz's work as proto-positivist or strictly empiricist is challenged, in favor of the claim that important elements of his theorizing can only be understood properly against the background of Fichte's Ego-doctrine.

  14. Franz von Leydig (1821-1908), pioneer of comparative histology.

    PubMed

    Schneider, Marlon R

    2012-05-01

    Franz von Leydig, a German histologist and zoologist, is known to every student of human or animal anatomy because of the testicular testosterone-producing cells carrying his name. However, he made many contributions to our knowledge of the fine structure of animal tissues, including more than 200 scientific articles and several books. His most important work, the book Lehrbuch der Histologie des Menschen und der Thiere, established him as a pioneer if not the founder of comparative histology. Leydig taught at three different universities (Würzburg, Tübingen and Bonn) and received many honours from scientific organizations worldwide, including the Royal Society. He died in Rothenburg ob der Tauber, the town of his birth, aged 86 years.

  15. ADAMTS13 and von Willebrand Factor in Thrombotic Thrombocytopenic Purpura

    PubMed Central

    Zheng, X. Long

    2015-01-01

    Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular injury. Deficiency of plasma ADAMTS13 activity (<10%) resulting from mutations of the ADAMTS13 gene or autoantibodies against ADAMTS13 causes hereditary or acquired (idiopathic) TTP. ADAMTS13 activity is usually normal or modestly reduced (>20%) in other forms of thrombotic microangiopathy secondary to hematopoietic progenitor cell transplantation, infection, and disseminated malignancy or in hemolytic uremic syndrome. Plasma infusion or exchange remains the initial treatment of choice to date, but novel therapeutics such as recombinant ADAMTS13 and gene therapy are under development. Moreover, ADAMTS13 deficiency has been shown to be a risk factor for the development of myocardial infarction, stroke, cerebral malaria, and preeclampsia. PMID:25587650

  16. Immunogold labelling of human von Willebrand factor adsorbed to collagen.

    PubMed

    Furlan, M; Robles, R; Lämmle, B; Zimmermann, J; Hunziker, E

    1991-06-01

    von Willebrand factor (vWF) mediates adhesion of platelets to the exposed subendothelium at sites of vascular injury. This function is expressed through binding of vWF to both collagen and receptors on the platelet membrane. We have developed a new method using immunogold staining and electron microscopy, permitting visualization of human vWF adsorbed to collagen fibrils. The electron micrographs revealed strings of gold beads reflecting the polymeric structure of vWF. Our data showed dramatic differences in the binding of vWF to collagens of different sources: high binding density was observed using a collagen preparation isolated from aortic tissue whereas colloidal gold was virtually absent from tendon collagen. Using the immunogold labelling method we demonstrated that high shear rate enhanced vWF binding to aortic collagen.

  17. Alexander von Humboldt's perceptions of colonial Spanish America.

    PubMed

    Rebok, Sandra

    2009-01-01

    This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind. PMID:19852391

  18. Alexander von Humboldt's perceptions of colonial Spanish America.

    PubMed

    Rebok, Sandra

    2009-01-01

    This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind.

  19. Ludwig von Bertalanffy's organismic view on the theory of evolution.

    PubMed

    Drack, Manfred

    2015-03-01

    Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented.

  20. SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor

    PubMed Central

    Zhu, Qiuyu; Yamakuchi, Munekazu; Lowenstein, Charles J.

    2015-01-01

    Endothelial exocytosis regulates vascular thrombosis and inflammation. The trafficking and release of endothelial vesicles is mediated by SNARE (Soluble NSF Attachment protein REceptors) molecules, but the exact identity of endothelial SNAREs has been unclear. Three SNARE molecules form a ternary complex, including isoforms of the syntaxin (STX), vesicle-associated membrane protein (VAMP), and synaptosomal-associated protein (SNAP) families. We now identify SNAP23 as the predominant endothelial SNAP isoform that mediates endothelial exocytosis of von Willebrand Factor (VWF). SNAP23 was localized to the plasma membrane. Knockdown of SNAP23 decreased endothelial exocytosis, suggesting it is important for endothelial exocytosis. SNAP23 interacted with the endothelial exocytic machinery, and formed complexes with other known endothelial SNARE molecules. Taken together, these data suggest that SNAP23 is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis. PMID:26266817

  1. John von Neumann and Klaus Fuchs: an Unlikely Collaboration

    NASA Astrophysics Data System (ADS)

    Bernstein, Jeremy

    2010-03-01

    I discuss the origin of the idea of making a fusion (hydrogen) bomb and the physics involved in it, and then turn to the design proposed for one by the unlikely collaborators John von Neumann and Klaus Fuchs in a patent application they filed at Los Alamos in May 1946, which Fuchs passed on to the Russians in March 1948, and which with substantial modifications was tested on the island of Eberiru on the Eniwetok atoll in the South Pacific on May 8, 1951. This test showed that the fusion of deuterium and tritium nuclei could be ignited, but that the ignition would not propagate because the heat produced was rapidly radiated away. Meanwhile, Stanislaw Ulam and C.J. Everett had shown that Edward Teller’s Classical Super could not work, and at the end of December 1950, Ulam had conceived the idea of super compression, using the energy of a fission bomb to compress the fusion fuel to such a high density that it would be opaque to the radiation produced. Once Teller understood this, he invented a greatly improved, new method of compression using radiation, which then became the heart of the Ulam-Teller bomb design, which was tested, also in the South Pacific, on November 1, 1952. The Russians have freely acknowledged that Fuchs gave them the fission bomb, but they have insisted that no one gave them the fusion bomb, which grew out of design involving a fission bomb surrounded by alternating layers of fusion and fission fuels, and which they tested on November 22, 1955. Part of the irony of this story is that neither the American nor the Russian hydrogen-bomb programs made any use of the brilliant design that von Neumann and Fuchs had conceived as early as 1946, which could have changed the entire course of development of both programs.

  2. Dynamics of Diffusion Flames in von Karman Swirling Flows Studied

    NASA Technical Reports Server (NTRS)

    Nayagam, Vedha; Williams, Forman A.

    2002-01-01

    Von Karman swirling flow is generated by the viscous pumping action of a solid disk spinning in a quiescent fluid media. When this spinning disk is ignited in an oxidizing environment, a flat diffusion flame is established adjacent to the disk, embedded in the boundary layer (see the preceding illustration). For this geometry, the conservation equations reduce to a system of ordinary differential equations, enabling researchers to carry out detailed theoretical models to study the effects of varying strain on the dynamics of diffusion flames. Experimentally, the spinning disk burner provides an ideal configuration to precisely control the strain rates over a wide range. Our original motivation at the NASA Glenn Research Center to study these flames arose from a need to understand the flammability characteristics of solid fuels in microgravity where slow, subbuoyant flows can exist, producing very small strain rates. In a recent work (ref. 1), we showed that the flammability boundaries are wider and the minimum oxygen index (below which flames cannot be sustained) is lower for the von Karman flow configuration in comparison to a stagnation-point flow. Adding a small forced convection to the swirling flow pushes the flame into regions of higher strain and, thereby, decreases the range of flammable strain rates. Experiments using downward facing, polymethylmethacrylate (PMMA) disks spinning in air revealed that, close to the extinction boundaries, the flat diffusion flame breaks up into rotating spiral flames (refs. 2 and 3). Remarkably, the dynamics of these spiral flame edges exhibit a number of similarities to spirals observed in biological systems, such as the electric pulses in cardiac muscles and the aggregation of slime-mold amoeba. The tail of the spiral rotates rigidly while the tip executes a compound, meandering motion sometimes observed in Belousov-Zhabotinskii reactions.

  3. Generalized information and entanglement entropy, gravitation and holography

    NASA Astrophysics Data System (ADS)

    Obregón, O.

    2015-06-01

    A nonextensive statistical mechanics entropy that depends only on the probability distribution is proposed in the framework of superstatistics. It is based on a Γ(χ2) distribution that depends on β and also on pl. The corresponding modified von Neumann entropy is constructed; it is shown that it can also be obtained from a generalized Replica trick. We further demonstrate a generalized H-theorem. Considering the entropy as a function of the temperature and volume, it is possible to generalize the equation of state of an ideal gas. Moreover, following the entropic force formulation a generalized Newton's law is obtained, and following the proposal that the Einstein equations can be deduced from the Clausius law, we discuss on the structure that a generalized Einstein's theory would have. Lastly, we address the question whether the generalized entanglement entropy can play a role in the gauge/gravity duality. We pay attention to 2d CFT and their gravity duals. The correction terms to the von Neumann entropy result more relevant than the usual UV ones and also than those due to the area dependent AdS3 entropy which result comparable to the UV ones. Then the correction terms due to the new entropy would modify the Ryu-Takayanagi identification between the CFT entanglement entropy and the AdS entropy in a different manner than the UV ones or than the corrections to the AdS3 area dependent entropy.

  4. Molecular evolution of the nuclear von Willebrand factor gene in mammals and the phylogeny of rodents.

    PubMed

    Huchon, D; Catzeflis, F M; Douzery, E J

    1999-05-01

    Nucleotide sequences of exon 28 of the von Willebrand Factor (vWF) were analyzed for a representative sampling of rodent families and eutherian orders, with one marsupial sequence as outgroup. The aim of this study was to test if inclusion of an increased taxonomic diversity in molecular analyses would shed light on three uncertainties concerning rodent phylogeny: (1) relationships between rodent families, (2) Rodentia monophyly, and (3) the sister group relationship of rodents and lagomorphs. The results did not give evidence of any particular rodent pattern of molecular evolution relative to a general eutherian pattern. Base compositions and rates of evolution of vWF sequences of rodents were in the range of placental variation. The 10 rodent families studied here cluster in five clades: Hystricognathi, Sciuridae and Aplodontidae (Sciuroidea), Muridae, Dipodidae, and Gliridae. Among hystricognaths, the following conclusions are drawn: a single colonization event in South America by Caviomorpha, a paraphyly of Old World and New World porcupines, and an African origin for Old World porcupines. Despite a broader taxonomic sampling diversity, we did not obtain a robust answer to the question of Rodentia monophyly, but in the absence of any other alternative, we cannot reject the hypothesis of a single origin of rodents. Moreover, the phylogenetic position of Lagomorpha remains totally unsettled.

  5. First principle nonlinear quantum dynamics using a correlation-based von Neumann entropy

    NASA Astrophysics Data System (ADS)

    Westermann, Till; Manthe, Uwe

    2012-05-01

    A new concept to describe the quantum dynamics in complex systems is suggested. It extends established schemes based on the Dirac-Frenkel variation principle, e.g., the multi-configurational time-dependent Hartree (MCTDH) approach. The concept is based on a correlation-based von Neumann entropy (CvN-entropy) definition measuring the complexity of the wavefunction. Equations of motion are derived using a CvN-entropy constraint in the variational principle and result in a generally applicable effective Hamiltonian. It consists of the standard Hamilton operator and an additional nonlinear operator which limits the complexity of the wavefunction. Effectively, this nonlinear operator absorbs complex structures which are emerging in the wavefunction and allows one to introduce non-norm conserving equations of motion. Important aspects of the new concept are outlined studying the wave packet propagation on the diabatic B2 potential energy surfaces of NO2. First, it is demonstrated that during standard wave packet propagation the CvN-entropy increases strongly with time roughly independent of the coordinate systems employed. Second, one finds that employing CvN-entropy constrained MCTDH propagation yields improved wave function accuracy on longer time scales while compromising on the short time accuracy. Third, the loss of the wavefunction's norm is directly related to the overlap with the exact wavefunction. This provides an error estimate available without knowing an exact reference.

  6. First principle nonlinear quantum dynamics using a correlation-based von Neumann entropy.

    PubMed

    Westermann, Till; Manthe, Uwe

    2012-05-28

    A new concept to describe the quantum dynamics in complex systems is suggested. It extends established schemes based on the Dirac-Frenkel variation principle, e.g., the multi-configurational time-dependent Hartree (MCTDH) approach. The concept is based on a correlation-based von Neumann entropy (CvN-entropy) definition measuring the complexity of the wavefunction. Equations of motion are derived using a CvN-entropy constraint in the variational principle and result in a generally applicable effective Hamiltonian. It consists of the standard Hamilton operator and an additional nonlinear operator which limits the complexity of the wavefunction. Effectively, this nonlinear operator absorbs complex structures which are emerging in the wavefunction and allows one to introduce non-norm conserving equations of motion. Important aspects of the new concept are outlined studying the wave packet propagation on the diabatic B(2) potential energy surfaces of NO(2). First, it is demonstrated that during standard wave packet propagation the CvN-entropy increases strongly with time roughly independent of the coordinate systems employed. Second, one finds that employing CvN-entropy constrained MCTDH propagation yields improved wave function accuracy on longer time scales while compromising on the short time accuracy. Third, the loss of the wavefunction's norm is directly related to the overlap with the exact wavefunction. This provides an error estimate available without knowing an exact reference. PMID:22667549

  7. From Wilhelm von Humboldt to Hitler-are prominent people more prone to have Parkinson's disease?

    PubMed

    Horowski; Horowski; Calne; Calne

    2000-10-01

    We describe Parkinsonism in prominent people, where Wilhelm von Humboldt and Adolf Hitler provide just two spectacular, opposing examples. In both of them, there is little if any evidence that the disease did influence their life ambitions, methods of achieving them or cognitive function in general. Thus, Hitler's Parkinsonism should remain a 'footnote' to history, and historians should acknowledge that in his last years, his trembling, his curbed posture, his slow walking, mask-like face and low voice did not indicate remorse, fear or depression as a consequence of his crimes, but were mere expressions of his disease which, until the end, had no impact on his intellectual skills and methods. The apparently higher incidence of Parkinsonism in prominent people may be just due to their higher visibility, or a consequence of disease-related personality traits (e.g. ambition, perfectionism, rigidity) which may contribute to becoming, e.g., a prominent authoritarian person. Perhaps even some early behaviour pattern (such as repressed emotions or acting in public-which could even increase the risk of some infection) contributes to a greater vulnerability for developing Parkinsonism. Further studying other prominent cases might lead us to better understanding of risk factors and the expression of early Parkinsonism. PMID:10900395

  8. From Wilhelm von Humboldt to Hitler-are prominent people more prone to have Parkinson's disease?

    PubMed

    Horowski; Horowski; Calne; Calne

    2000-10-01

    We describe Parkinsonism in prominent people, where Wilhelm von Humboldt and Adolf Hitler provide just two spectacular, opposing examples. In both of them, there is little if any evidence that the disease did influence their life ambitions, methods of achieving them or cognitive function in general. Thus, Hitler's Parkinsonism should remain a 'footnote' to history, and historians should acknowledge that in his last years, his trembling, his curbed posture, his slow walking, mask-like face and low voice did not indicate remorse, fear or depression as a consequence of his crimes, but were mere expressions of his disease which, until the end, had no impact on his intellectual skills and methods. The apparently higher incidence of Parkinsonism in prominent people may be just due to their higher visibility, or a consequence of disease-related personality traits (e.g. ambition, perfectionism, rigidity) which may contribute to becoming, e.g., a prominent authoritarian person. Perhaps even some early behaviour pattern (such as repressed emotions or acting in public-which could even increase the risk of some infection) contributes to a greater vulnerability for developing Parkinsonism. Further studying other prominent cases might lead us to better understanding of risk factors and the expression of early Parkinsonism.

  9. Heavy menstrual bleeding and health-associated quality of life in women with von Willebrand's disease

    PubMed Central

    GOVOROV, IGOR; EKELUND, LENA; CHAIRETI, ROZA; ELFVINGE, PETRA; HOLMSTRÖM, MARGARETA; BREMME, KATARINA; MINTS, MIRIAM

    2016-01-01

    Women with the inherited bleeding disorder von Willebrand's disease (VWD) face gender-specific hemostatic challenges during menstruation. Heavy menstrual bleeding (HMB) can negatively affect their overall life activities and the health-associated quality of life. The purpose of the present study was to investigate whether women with VWD experienced HMB and an impaired health-associated quality of life. The study subjects were recruited from the Coagulation Unit of Karolinska University Hospital. Information was retrieved from various self-administered forms and medical records. Of the 30 women (18–52 years) that were included in the present study, 50% suffered from HMB, although the majority received treatment for HMB. In addition, almost all the included women perceived limitations in the overall life activities due to menstruation. The health-associated quality of life for women with HMB was significantly lower (P<0.10) with regards to ‘bodily pain’ compared with Swedish women of the general population. In conclusion, women with VWD experienced reduced health-associated quality of life as a result of HMB. Therefore, preventing limitations in overall life activities and improving their health-associated quality of life thorough counseling on menstrual bleeding is important for women with VWD. PMID:27168829

  10. General energetics

    SciTech Connect

    Smil, V.

    1991-01-01

    This book is a comprehensive sourcebook for planetary management and strategies for sustainable development. Coupling biospheric and civilizational aspects, the book features thorough treatments of all critical energy storages, flows, and conversions. Measurements of energy and power densities and intensities are used throughout the book to provide an integrated framework of analysis for all segments of energetics from planetary and bioenergetics to the human energetics of hunting-gathering and agricultural societies through modern industrial civilization. Coverage also examines the environmental and socio-economic implication of the general patterns and trends of modern energy use.

  11. von Neumann's Law: Theoretical and Microgravity Experimental Comparison for Coarsening Diffusion in Bubble Lattices

    NASA Technical Reports Server (NTRS)

    Noever, David A.

    2000-01-01

    The effects of gravity in influencing the theoretical limit for bubble lattice coarsening and aging behavior, otherwise called von Neumann's law, is examined theoretically and experimentally. Preliminary microgravity results will be discussed.

  12. Successful Aortic Aneurysm Repair in a Woman with Severe von Willebrand (Type 3) Disease

    PubMed Central

    Campbell, Victoria; Marriott, Kevin; Stanbridge, Rex; Shlebak, Abdul

    2015-01-01

    von Willebrand disease type 3 (VWD3) is a rare but the most severe form of von Willebrand disease; it is due to almost complete lack of von Willebrand factor activity (VWF:RCo). It is inherited as autosomal recessive trait; whilst heterozygote carriers have mild, or no symptoms, patients with VWD3 show severe bleeding symptoms. In the laboratory, this is characterised by undetectable VWF:Ag, VWF:RCo, and reduced levels of factor VIII < 0.02 IU/dL. The bleeding is managed with von Willebrand/FVIII factor concentrate replacement therapy. In this rare but challenging case we report on the successful excision and repair of an ascending aortic aneurysm following adequate VWF/FVIII factor concentrate replacement using Haemate-P. PMID:25960895

  13. Alexander von Humboldt's charts of the Earth's magnetic field: an assessment based on modern models

    NASA Astrophysics Data System (ADS)

    Mandea, M.; Korte, M.; Soloviev, A.; Gvishiani, A.

    2010-11-01

    The 19th century witnessed a resurgence of interest in Earth's magnetic field. Both observational and theoretical aspects were involved, and one of the emblematic figures of this period was Alexander von Humboldt. Throughout a long life he maintained a strong interest in a broad area of subjects, however, here we are interested in his role in geomagnetism, and particularly in his pioneering contributions to charting the geomagnetic field. Alexander von Humboldt efforts in measuring and charting the Earth's magnetic field are recounted and the maps of declination, inclination and total intensity he had prepared are compared, favorably, with maps for the same epoch based on a modern model of the geomagnetic field, gufm1. This modern assessment of the accuracy of von Humboldt's geomagnetic charts illustrates the importance of his work, being also our homage to the 150th anniversary of the death of Alexander von Humboldt.

  14. President Kennedy, Vice President Johnson and Dr. von Braun at Redstone Airfield

    NASA Technical Reports Server (NTRS)

    1962-01-01

    President John F. Kennedy, Vice President Lyndon B. Johnson and Marshall Space Flight Center Director Dr. Wernher von Braun at the Redstone Arsenal Airfield, September 11, 1962. Kennedy and Johnson visited the Marshall Center to tour national space facilities.

  15. Wilhelm Julius Foerster und die "Vereinigung von Freunden der Astronomie und kosmischen Physik" (1891 bis 1914).

    NASA Astrophysics Data System (ADS)

    Tiemann, K.-H.

    Am 19. Mai 1891 wurde ins Leben gerufen die "Vereinigung von Freunden der Astronomie und der kosmischen Physik (nachfolg.: V.A.P.) - eine der beiden institutionellen Vorläufer der sich 1953 konstituierenden "Vereinigung der Sternfreunde".

  16. APOLLO 14 DR. WERNHER VON BRAUN WATCHES FROM FIRING ROOM 2

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Dr. Wernher von Braun, the NASA Deputy Associate Administrator for Future Programs, uses binoculars to monitor data on closed- circuit television screens in Firing Room 2 of the Launch Control Center during final Apollo 14 launch preparations today.

  17. [Richard von Krafft-Ebing (1840-1902. In memory of the 100th anniversary of his death].

    PubMed

    Sigusch, V

    2004-01-01

    Richard von Krafft-Ebing was a famous psychiatrist and sex researcher. However, little is known reliably about his life and work. The author was the first with the opportunity to review Krafft-Ebing's papers, which only recently had become accessible. Based on original documents, Krafft-Ebing's history is outlined. While Krafft-Ebing as general psychiatrist only followed the ongoing modernization and liberalization in his field, he was a pioneer of modern forensic psychiatry in his writings, opinions, and especially his viewpoint, emphasizing individual rights and responsibilities. In the field of sexual psychopathology, he basically summarized known case reports but did not lay down theoretical or therapeutic foundations for modern sexual science.

  18. [Anton Ritter von Frisch (1849-1917): life and work of the first President of the German Society of Urology].

    PubMed

    Hatzinger, M

    2011-06-01

    Professor Dr. Anton Ritter von Frisch was born in Vienna on 16 February 1849 where he was appointed Head of the Special Department for Diseases of the Urinary Organs at the General Polyclinic in 1889. Numerous publications and textbooks on urology can be attributed to him. From a historical perspective, he is particularly distinguished by the fact that he was elected as the first President of the German Society of Urology in 1907 in Vienna and was even designated to become President for a second time for the 1915 Congress, which however was never organized due to the outbreak of World War I. His early death in 1917 at the age of only 68 brought an end to his exceptionally productive and successful efforts on the part of urology. PMID:21559916

  19. Principle of reciprocity solves the most important problems in bioimpedance and in general in bioelectromagnetism

    NASA Astrophysics Data System (ADS)

    Malmivuo, Jaakko

    2010-04-01

    Though the principle of reciprocity was invented by Hermann von Helmholtz already over 150 years ago, and though it is a very powerful tool in solving various important problems in bioelectromagnetism, it is not generally used. In impedance tomography the measurement sensitivity distribution has generally been misunderstood. This can be easily demonstrated with the principle of reciprocity. Some other applications of the principle of reciprocity are also discussed.

  20. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.

    PubMed

    James, A H; Konkle, B A; Kouides, P; Ragni, M V; Thames, B; Gupta, S; Sood, S; Fletcher, S K; Philipp, C S

    2015-01-01

    The aim of this study was to elucidate the fall in von Willebrand factor (VWF) and factor VIII activity (FVIII) after childbirth in women with and without von Willebrand disease (VWD). VWF:RCo, VWF:Ag, and FVIII were obtained in the third trimester of pregnancy, on admission for childbirth, and 10 times postpartum. Specimens were processed within 4 h and analysed centrally. Means were calculated at each time point. Forty women (40 pregnancies) without VWD and 32 women (35 pregnancies) with VWD were enrolled. 15/32 with VWD were treated (30% of those with type 1 and all of those with type 2) in 17 pregnancies. Treatments prior to delivery consisted of desmopressin (2/17), VWF concentrate (15/17) and after delivery VWF concentrate (16/17). Duration of treatment was 0-21 days (median 6). VWF levels peaked at 250% of baseline--4 h postpartum in women with VWD and 12 h postpartum in women without VWD. Thereafter, VWF levels fell rapidly, approached baseline at 1 week and reached baseline at 3 weeks. Except immediately postpartum, when the levels among treated cases were higher, levels among women with VWD appeared to parallel, but were lower than those among women without VWD. Levels were lowest among those who received treatment. VWF levels fall rapidly after childbirth. Except immediately postpartum, current treatment strategies do not raise VWF levels to the levels of women without VWD or even to the levels of women with milder, untreated VWD. Consequently, women with VWD may be at risk of postpartum haemorrhage despite treatment.

  1. In memory of Eugene (Jenő) von Gothard: a pioneering nineteenth century Hungarian astrophysicist

    NASA Astrophysics Data System (ADS)

    Vincze, Ildikő J.; Jankovics, István

    2012-07-01

    Eugene von Gothard was a Hungarian engineer/scientist, instrument-maker and astrophysicist who founded the Herény Astrophysical Observatory in 1881 and carried out pioneering work in astronomical photography and spectroscopy. In this paper we provide biographical material about von Gothard and describe his observatory, before discussing his astronomical observations and the contribution that hemade to the early development of astrophysics.

  2. Neuere Untersuchungen zur Prädiktion von EEG-Signalen bei Epilepsie

    NASA Astrophysics Data System (ADS)

    Niederhöfer, C.; Tetzlaff, R.

    2007-06-01

    Seit einigen Jahren ist die Analyse von EEG-Signalen bei Epilepsie Gegenstand zahlreicher wissenschaftlicher Arbeiten; Zielvorstellung ist dabei die Entwicklung von Verfahren zur Erkennung eines möglichen Voranfallszustandes. Im Vordergrund steht beispielsweise die Approximation einer so genannten effektiven Korrelationsdimension, die Bestimmung der maximalen Lyapunov-Exponenten, Detektionsverfahren für Muster bei Zellularen Nichtlinearen Netzwerken, die Bestimmung der mittleren Phasenkohärenz und Verfahren zur nichtlinearen Prädiktion von EEG-Signalen. Trotz umfangreicher Bemühungen kann bis heute eine Erkennung von Anfallsvorboten mit einer Sensitivität und Spezifität, die eine automatisierte Anfallsvorhersage ermöglichen würde, noch nicht durchgeführt werden. In diesem Beitrag werden neue Ergebnisse zur Prädiktion von EEG-Signalen bei Epilepsie vorgestellt. Dabei werden Signale, welche mittels intrakranieller electrocorticographischer (ECoG) und stereoelectroencephalographischer (SEEG) Ableitungen registriert wurden, segmentweise analysiert. Unter der Annahme, dass sich Änderungen des Systems ,,Gehirn" als Änderungen im Prädiktor, d.h. in seinen Systemparametern widerspiegeln, könnte eine nähere Betrachtung der Prädiktoreigenschaften zu einer Erkennung von Anfallsvorboten führen.

  3. Fibroblast growth factor-10 signals development of von Brunn's nests in the exstrophic bladder.

    PubMed

    Eastman, Rocky; Leaf, Elizabeth M; Zhang, Dianzhong; True, Lawrence D; Sweet, Robert M; Seidel, Kristy; Siebert, Joseph R; Grady, Richard; Mitchell, Michael E; Bassuk, James A

    2010-11-01

    von Brunn's nests have long been recognized as precursors of benign lesions of the urinary bladder mucosa. We report here that von Brunn's nests are especially prevalent in the exstrophic bladder, a birth defect that predisposes the patient to formation of bladder cancer. Cells of von Brunn's nest were found to coalesce into a stratified, polarized epithelium which surrounds itself with a capsule-like structure rich in types I, III, and IV collagen. Histocytochemical analysis and keratin profiling demonstrated that nested cells exhibited a phenotype similar, but not identical, to that of urothelial cells of transitional epithelium. Immunostaining and in situ hybridization analysis of exstrophic tissue demonstrated that the FGF-10 receptor is synthesized and retained by cells of von Brunn's nest. In contrast, FGF-10 is synthesized and secreted by mesenchymal fibroblasts via a paracrine pathway that targets basal epithelial cells of von Brunn's nests. Small clusters of 10pRp cells, positive for both FGF-10 and its receptor, were observed both proximal to and inside blood vessels in the lamina propria. The collective evidence points to a mechanism where von Brunn's nests develop under the control of the FGF-10 signal transduction system and suggests that 10pRp cells may be the original source of nested cells.

  4. Generalized pustular psoriasis induced by systemic steroid dose reduction*

    PubMed Central

    Westphal, Danielle Cristine; Schettini, Antonio Pedro Mendes; de Souza, Petra Pereira; Castiel, Jessica; Chirano, Carlos Alberto; Santos, Mônica

    2016-01-01

    Generalized pustular psoriasis, or psoriasis of von Zumbusch, is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this work, we report the case of a female patient, 70 years old, who developed generalized pustular psoriasis symptoms while reducing the dose of oral corticosteroids, improperly introduced for the treatment of alleged acute generalized exanthematous pustulosis. The differential diagnosis of generalized pustular psoriasis should be made with other pustular dermatoses, such as subcorneal pustulosis, IgA pemphigus and especially with acute generalized exanthematous pustulosis. Personal history of psoriasis and histopathological findings with psoriasiform changes and subcorneal pustule favored the diagnosis. She was treated with acitretin 30 mg / day, progressing to complete regression of the lesions.

  5. Bayesian estimation of slip distribution based on von Karman autocorrelation

    NASA Astrophysics Data System (ADS)

    Hooper, A. J.; Bekaert, D. P.

    2014-12-01

    Geodetic observations from techniques such as InSAR and GNSS are routinely used to invert for earthquake fault slip distributions. However, in order to regularize the inversions, extra arbitrary assumptions about the smoothness of the slip distribution are usually included. In previous work we explored a new approach for constraining the slip distribution based on a random vector model following a von Karman autocorrelation function, which has empirical support from a stochastic analysis of seismic finite-source slip inversions. We implemented the random vector constraint in a Bayesian fashion and used a Markov chain Monte Carlo (MCMC) algorithm to derive the posterior joint probability distribution for each of the slipping patches. The von Karman function depends on two parameters: correlation length and Hurst number (related to fractal dimension). In our inversions we used the empirically derived maximum likelihood values for these two parameters, which differ in along-strike and down-dip directions, and with fault mechanism. However, the inversion results depend strongly on the chosen values for correlation length and Hurst number, and the empirically derived histograms show that there is in fact quite some variation between earthquakes with the same mechanism. In our extended approach we treat these two parameters as hyperparameters, with the prior probability distribution constrained by the empirical histograms. The values are thus also allowed to vary in our Bayesian inversion scheme. In this way, the uncertainty in the parameters that define the autocorrelation function is also included in the posterior probability distribution for the slipping patches. To ensure that our MCMC algorithm converges rapidly, we have implemented a variation to the usual MCMC approach, in which the maximum step size for each of the model parameters is initially updated regularly, until optimal values are achieved. In comparisons between our new approach and a more standard

  6. Schirmwirkung von Hochfrequenz (HF)-Schutzkleidung: Untersuchung verschiedener Konstruktionsmerkmale

    NASA Astrophysics Data System (ADS)

    Arps, V.; Scheibe, K.

    2005-05-01

    Die Messverfahren zur Bestimmung der Schutzwirkung von HF-Schutzkleidung sind in der Norm DIN 32780-100 festgelegt. Entsprechend diesen Anforderungen wird die elektrische und magnetische Schirmdämpfung bestimmt und daraus als Maß für die Schutzwirkung die elektromagnetische Schirmdämpfung berechnet. Diese ist eine der SAR vergleichbare Größe. In diesem Beitrag werden die Einflüsse verschiedener Konstruktionsmerkmale von HF-Schutzanzügen auf die elektromagnetische Schirmdämpfung untersucht. Zu diesen gehören die nach MIL STD 285 vermessene elektrische Schirmdämpfung der verwendeten Gewebe. Weiter werden verschiedene Teilbereiche der HF-Schutzkleidung auf ihre Schutzwirkung untersucht. Der Schwerpunkt liegt hierbei auf der Fragestellung inwieweit Verschlüsse, Reißverschlüsse oder leitfähiges Klettband, die Schutzwirkung beeinträchtigen. Zu diesem Zweck werden zwei Schutzanzüge unterschiedlicher Konstruktion vergleichend vermessen. Es handelt sich dabei um einen bereits im Handel befindlichen und entsprechend der Norm zertifizierten Anzug und einen neuen Prototyp, welcher nach verschiedenen Gesichtspunkten optimiert wurde. Schwachstellen der Konstruktion werden herausgearbeitet und Ansatzpunkte für weitere Verbesserungen erarbeitet. The measuring methods for determining the shielding effectiveness of radiofrequency (RF)-protective clothing are defined in German Standard DIN 32780-100. According to this standard, both the electric and the magnetic shielding effectiveness are measured in order to calculate the electromagnetic shielding effectiveness. The electromagnetic shielding effectiveness is an adequate quality criterion for the degree of protection and also compares well with the Specific Absorption Rate (SAR). In this article, the impact of different design features on the electromagnetic shielding effectiveness is analyzed. The electric shielding effectiveness of the used shielding materials is measured according to MIL STD 285 and thereupon

  7. Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease.

    PubMed

    Shively, Sharon B; Falke, Eric A; Li, Jie; Tran, Maxine G B; Thompson, Eli R; Maxwell, Patrick H; Roessler, Erich; Oldfield, Edward H; Lonser, Russell R; Vortmeyer, Alexander O

    2011-08-01

    There is increasing evidence that suggests that knockout of tumor-suppressor gene function causes developmental arrest and protraction of cellular differentiation. In the peripheral nervous system of patients with the tumor-suppressor gene disorder, von Hippel-Lindau disease, we have demonstrated developmentally arrested structural elements composed of hemangioblast progenitor cells. Some developmentally arrested structural elements progress to a frank tumor, hemangioblastoma. However, in von Hippel-Lindau disease, hemangioblastomas are frequently observed in the cerebellum, suggesting an origin in the central nervous system. We performed a structural and topographic analysis of cerebellar tissues obtained from von Hippel-Lindau disease patients to identify and characterize developmentally arrested structural elements in the central nervous system. We examined the entire cerebella of five tumor-free von Hippel-Lindau disease patients and of three non-von Hippel-Lindau disease controls. In all, 9 cerebellar developmentally arrested structural elements were detected and topographically mapped in 385 blocks of von Hippel-Lindau disease cerebella. No developmentally arrested structural elements were seen in 214 blocks from control cerebella. Developmentally arrested structural elements are composed of poorly differentiated cells that express hypoxia-inducible factor (HIF)2α, but not HIF1α or brachyury, and preferentially involve the molecular layer of the dorsum cerebelli. For the first time, we identify and characterize developmentally arrested structural elements in the central nervous system of von Hippel-Lindau patients. We provide evidence that developmentally arrested structural elements in the cerebellum are composed of developmentally arrested hemangioblast progenitor cells in the molecular layer of the dorsum cerebelli.

  8. Scaling of Von Neumann Entropy at the Anderson Transition

    NASA Astrophysics Data System (ADS)

    Chakravarty, Sudip

    Extensive body of work has shown that for the model of a non-interacting electron in a random potential there is a quantum critical point for dimensions greater than two — a metal-insulator transition. This model also plays an important role in the plateau-to-plateu transition in the integer quantum Hall effect, which is also correctly captured by a scaling theory. Yet, in neither of these cases the ground state energy shows any non-analyticity as a function of a suitable tuning parameter, typically considered to be a hallmark of a quantum phase transition, similar to the non-analyticity of the free energy in a classical phase transition. Here we show that von Neumann entropy (entanglement entropy) is non-analytic at these phase transitions and can track the fundamental changes in the internal correlations of the ground state wave function. In particular, it summarizes the spatially wildly fluctuating intensities of the wave function close to the criticality of the Anderson transition. It is likely that all quantum phase transitions can be similarly described.

  9. Empathy and identification in Von Donnersmarck's The Lives of Others.

    PubMed

    Diamond, Diana

    2008-09-01

    Florian Henckel von Donnersmarck's The Lives of Others, set in the German Democratic Republic in 1984, five years before the fall of the Berlin Wall, has been called the first accurate depiction of the psychological terror wielded by the Stasi, the East German secret police, who safeguarded the dictatorship of the proletariat. The film is about the psychological and political transformation of a Stasi officer, Wiesler, who undertakes the surveillance of a prominent playwright and his actress lover. The mechanisms through which Wiesler comes to empathize and identify with the subjects of his investigation, as he observes and listens in on the rich blend of passion, poetry, and politics that characterizes their lives, are explored in depth. Wiesler's transformation is based in part on the capacity to form implicit models of the behavior and experiences of others, based on the mirror neuron system, that Gallese and his colleagues call "embodied simulation." Underpinning the processes of empathy and identification so central to this film, embodied simulation is an unconscious and prereflexive mechanism through which the actions, emotions, and sensations we observe activate internal representations of the bodily and mental states of the other. Embodied simulation also expands our understanding of the power of the primal scene, which has long been identified as a major organizer of unconscious fantasies and conflicts throughout life, and which forms the central metaphor of the film. Embodied simulation scaffolds our aesthetic response to art, music, and literature, underlies the dynamics of spectatorship, and potentially catalyzes resistance to totalitarian mass movements. PMID:18802131

  10. Von recklinghausen disease: one patient – various problems

    PubMed Central

    Miziołek, B; Brzezińska-Wcisło, L

    2016-01-01

    Abstract von Recklinghausen disease (vRD), more widely known as neurofibromatosis type 1, belongs to a group of genetic disorders and it is considered to be the most common genodermatosis. The disease has an autosomal dominant pattern of inheritance that involves mutations within the NF1 gene located on chromosome 17 in locus q11.2. The product of the NF1 gene is neurofibromin and the protein is well known to be a tumor suppressor factor. This counteracts possible overactivity of RAS (protein)/MAPK (mitogen-activated protein kinase) and RAS/PI3K/AKT/mTOR (phoshatydyloinositol-3-kinase/V-akt murine thy-moma viral oncogene homologue/mammalian target of rapamycin) signaling transduction pathways, preventing from uncontrolled cell proliferation and subsequent tumor formation. A loss of proper functioning of this protein leads to a development of vRD; however, a large variability in a phenotype of the disease and the onset of cutaneous findings, not necessarily in childhood, may provide a clinical diagnosis of the disease late in adulthood. We present a 52-year-old male in whom the diagnosis of vRD was proposed in the sixth decade of life, despite of multiple nodular lesions disseminated over the skin of the whole body and different neurological disturbances, not considered for a long time as manifestations of genodermatosis.

  11. Front End Schaltung zur Online Auswertung von EKG-Signalen

    NASA Astrophysics Data System (ADS)

    Ayari, E.; Tielert, R.

    2007-06-01

    Ein mobiles EKG-System zur Online Auswertung von EKG-Signalen wird dargestellt. Die Auswertung beruht auf ein energiesparendes Verfahren, das den Vorteil einer zulässigen Unterabtastung des Signals bietet und eine Interaktion zwischen der messenden Elektronik und dem funkgebundenen Auswertungsrechner ermöglicht. Diese Interaktion besteht darin, sowohl die Front End Schaltung im EKG-Sensor als auch den im ATmega8L eingebetteten A/D-Wandler vom Auswertungsrechner zu steuern und den Datenbedarf des Rechners dynamisch an die Erfordernisse des Analyseprogramms anzupassen. Das entwickelte EKG-System liefert erfolgreiche Charakterisierungen erfasster Elektrokardiogramme. A mobile ecg-system for an online analysis of electrocardiogram signals is presented. The analysis is based on an energy-saving procedure, which offers the advantage of an acceptable undersampling of the signal, and which allows an interaction between the measuring electronic and the radio-bound analysis-computer. In this interaction both the front-end circuit in the ecg-sensor and the A/D converter, which is embedded in the ATmega8L, are steered by the analysis computer. The data requirement of the computer is also dynamically adapted to the requirements of the analysis-program. The developed ecg-system supplies successful characterisations of measured electrocardiograms.

  12. [Hans von Hattingberg between psychoanalysis and National Socialism].

    PubMed

    Keifenheim, Katharina Eva

    2011-01-01

    Hans von Hattingberg (1879-1944) worked as a neurologist and psychoanalyst in Munich and Berlin from about 1910 to 1944. He was a prolific writer, but met with increasing disapproval from Freud and his circle. An advocate of the union of different psychotherapeutic schools, he was initially a marginal figure in the professional field. With Hitler's rise to power his career prospered: He was offered the position of a lecturer for psychotherapy and became head of the research department at the "Göring Institute". He came to prominence with his writings on the "Neue deutsche Seelenheilkunde" despite the fact that this was never his preferred topic. The main themes of his publications were marriage, love and female emancipation. Those works contain only little of the standard Nazi ideology of the time. Not only was Hattingberg never a member of the NSDAP (the ruling party), but in some respects he could conceivably be considered a member of the resistance. The article outlines the most important stages of Hattingberg's life and focuses on the question of how he positioned himself after 1933, when it became vital for him to reconcile psychoanalysis and National Socialism.

  13. Empathy and identification in Von Donnersmarck's The Lives of Others.

    PubMed

    Diamond, Diana

    2008-09-01

    Florian Henckel von Donnersmarck's The Lives of Others, set in the German Democratic Republic in 1984, five years before the fall of the Berlin Wall, has been called the first accurate depiction of the psychological terror wielded by the Stasi, the East German secret police, who safeguarded the dictatorship of the proletariat. The film is about the psychological and political transformation of a Stasi officer, Wiesler, who undertakes the surveillance of a prominent playwright and his actress lover. The mechanisms through which Wiesler comes to empathize and identify with the subjects of his investigation, as he observes and listens in on the rich blend of passion, poetry, and politics that characterizes their lives, are explored in depth. Wiesler's transformation is based in part on the capacity to form implicit models of the behavior and experiences of others, based on the mirror neuron system, that Gallese and his colleagues call "embodied simulation." Underpinning the processes of empathy and identification so central to this film, embodied simulation is an unconscious and prereflexive mechanism through which the actions, emotions, and sensations we observe activate internal representations of the bodily and mental states of the other. Embodied simulation also expands our understanding of the power of the primal scene, which has long been identified as a major organizer of unconscious fantasies and conflicts throughout life, and which forms the central metaphor of the film. Embodied simulation scaffolds our aesthetic response to art, music, and literature, underlies the dynamics of spectatorship, and potentially catalyzes resistance to totalitarian mass movements.

  14. Ludwig von Bertalanffy's Organismic View on the Theory of Evolution

    PubMed Central

    Drack, Manfred

    2015-01-01

    Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 77–90, 2015. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals, Inc. PMID:25727202

  15. VASCULOGENESIS IN VON HIPPEL-LINDAU DISEASE ASSOCIATED TUMORS

    PubMed Central

    Lonser, Russell R.; Frerich, Jason; Huntoon, Kristin; Yang, Chunzhang; Merrill, Marsha; Abdullaev, Ziedulla; Pack, Svetlana; Shively, Sharon; Stamp, Gordon; Zhuang, Zhengping

    2014-01-01

    BACKGROUND: Emerging data indicate that von Hippel-Lindau disease (VHL) associated tumors arise from embryologic hemangioblasts that can form vessels (endothelial cells) and blood cells. Nevertheless, the origin of VHL-associated vasculature is not known. To determine the origin of VHL-associated tumor vasculature, we investigated the neoplastic vasculature from VHL patients. METHODS: Microdissected VHL-associated tumor (compared to control non-VHL tissues) vascular features were examined using immunohistochemical staining for CA9, HIF-2a, HIF-1a, CD31 and Factor VIIIa. Origin of tumor vascular elements (tumor versus non-tumor) was assessed by LOH and FISH analysis. Intratumoral vasculogenesis was assessed in vivo using the VHL-deficient UMRC6 renal carcinoma murine xenograft model. RESULTS: We demonstrate that isolated vascular structures and blood vessels within VHL-associated neoplasms (including hemangioblastomas, renal cell carcinoma and pancreatic tumors) are a result of tumor-derived vasculogenesis. Further, similar to hemangioblastomas, other VHL-associated neoplasms possess vascular tissue of tumor origin. Similarly, tumor-derived endothelial cells emerge within implanted VHL deficient UMRC6 renal cell carcinoma murine xenografts. CONCLUSIONS: These findings further establish the embryologic, developmentally arrested, hemangioblast as the tumor cell of origin for VHL-associated hemangioblastomas and indicate that it is also the progenitor cell for other VHL-associated tumors. SECONDARY CATEGORY: Neuropathology & Tumor Biomarkers.

  16. [Heinrich von Kleist--crisis and creative overcoming].

    PubMed

    Schlimme, J

    2001-07-01

    Heinrich von Kleist's life was shaken repeatedly by negative life-events, finally he committed suicide in his last life-crisis (1811). His work was mostly understood as descriptions of negative life-events and failed-being. In this article it will be shown that in at least two "crises" Kleist's work can be understood as a creative overcome of those. Kleist shows in his "Essay to Find a Sure Way to Happiness" (1799) his way of solving his "Soldier-Crisis" (1798), a depressive episode. In "The Broken Jug" (1802 - 1805) he shows the implications of a philosophical problem experienced in his "Kant-Crisis" (1801) and offers chances to overcome this particular crisis, which still seems to be an actual problem of ourselves. Though his crises must be understood as depressive episodes, at least the "Kant-Crisis" with its connections to philosophical and artistical matters seems to be more complicated than a simple depressive syndrome. Kleist formulates his basic life-experience, to be repeatedly shaken by "crises" respectively depressive episodes and the necessity to overcome each in a new way of living.

  17. Emperor Ashoka: Did he suffer from von Recklinghausen's diseases?

    PubMed Central

    Wig, N. N.; Sharma, Sheetal

    2015-01-01

    Emperor Ashoka is widely regarded as one of the greatest rulers of India. This paper mainly deals with his medical condition as recorded in the Buddhist texts of Sri Lanka as well as in the Buddhist texts of North India and Nepal. These sources mention his skin disorder which is described as very rough and unpleasant to touch. He is also known to have episodes of loss of consciousness at various times in his life. One of the earliest representations of Ashoka, about 100 years after his death at one of the gates of Sanchi Stupa, shows Ashoka fainting when visiting the Bodhi tree and being held by his queens. In this sculpture, Emperor Ashoka is shown as a man of short height, large head and a paunchy abdomen. In this paper, it is speculated that Emperor Ashoka was probably suffering from von Recklinghausen disease (Neurofibromatosis Type 1), which could explain his skin condition, episodes of loss of consciousness (probably epilepsy) and other bodily deformities. PMID:25657467

  18. Minimal Coupling in Koopman-von Neumann Theory

    NASA Astrophysics Data System (ADS)

    Gozzi, E.; Mauro, D.

    2002-03-01

    Classical mechanics (CM), like quantum mechanics (QM), can have an operatorial formulation. This was pioneered by Koopman and von Neumann (KvN) in the 1930s. They basically formalized, via the introduction of a classical Hilbert space, earlier work of Liouville who had shown that the classical time evolution can take place via an operator, nowadays known as the Liouville operator. In this paper we study how to perform the coupling of a point particle to a gauge field in the KvN version of CM. So we basically implement at the classical operatorial level the analog of the minimal coupling of QM. We show that, differently than in QM, not only the momenta but also other variables have to be coupled to the gauge field. We also analyze in detail how the gauge invariance manifests itself in the Hilbert space of KvN and indicate the differences with QM. As an application of the KvN method we study the Landau problem proving that there are many more degeneracies at the classical operatorial level than at the quantum one. As a second example we go through the Aharonov-Bohm phenomenon showing that, at the quantum level, this phenomenon manifests its effects on the spectrum of the quantum Hamiltonian while at the classical level there is no effect whatsoever on the spectrum of the Liouville operator.

  19. Early turbulence in von Karman swirling flow of polymer solutions

    NASA Astrophysics Data System (ADS)

    Burnishev, Yuri; Steinberg, Victor

    2015-01-01

    We present quantitative experimental results on the transition to early turbulence in von Karman swirling flow of water- and water-sugar-based polymer solutions compared to the transition to turbulence in their Newtonian solvents by measurements of solely global quantities as torque Γ(t) and pressure p(t) with large statistics as a function of Re. For the first time the transition values of Re_c\\textit{turb} to fully developed turbulence and turbulent drag reduction regime Re_c\\textit{TDR} are obtained as functions of elasticity El by using the solvents with different viscosities and polymer concentrations ϕ. Two scaling regions for fundamental turbulent characteristics are identified and they correspond to the turbulent and TDR regimes. Both Re_c\\textit{turb} and Re_c\\textit{TDR} are found via the dependence of the friction coefficient Cf and Cp, defined through scaled average torque \\barΓ and rms pressure fluctuations p\\textit{rms} , respectively, on Re for different El and ϕ and via the limits of the two scaling regions.

  20. von Willebrand factor binds to platelets and induces aggregation in platelet-type but not type IIB von Willebrand disease.

    PubMed Central

    Miller, J L; Kupinski, J M; Castella, A; Ruggeri, Z M

    1983-01-01

    Platelet-type von Willebrand disease (vWD) and pseudo-vWD are two recently described intrinsic platelet defects characterized by enhanced ristocetin-induced agglutination in platelet-rich plasma. A similar finding is also typical of type IIB vWD, where it has been related to a von Willebrand factor (vWF) rather than a platelet abnormality. Platelet aggregation induced by unmodified human vWF in the absence of other stimuli has been reported in pseudo-vWD. In this study we demonstrate that vWF induces aggregation in platelet-type but not type IIB vWD. Aggregation is observed when normal plasma cryoprecipitate or purified vWF are added to platelet-rich plasma. Cryoprecipitate also aggregates washed platelets, although at higher concentrations than required for platelet-rich plasma. Purified vWF, however, induces significant aggregation of washed platelets only when plasma is added. EDTA inhibits vWF-induced aggregation. Its effect can be overcome by calcium but much less effectively by magnesium ions. Unstimulated platelets in platelet-rich plasma from patients with platelet-type but not type IIB vWD bind 125I-vWF in a specific and saturable manner. All different sized multimers of vWF become associated with platelets. Both aggregation and binding exhibit a similar vWF concentration dependence, suggesting that a correlation exists between these two events. Removal of ADP by appropriate consuming systems is without effect upon such binding or upon vWF-induced aggregation. Thrombin-induced 125I-vWF binding to washed platelets is normal in platelet-type as well as type IIB vWD. These results demonstrate that a specific binding site for unmodified human vWF is exposed on unstimulated platelets in platelet-type vWD. The relatively high vWF concentrations required for aggregation and binding may explain the lack of significant in vivo aggregation and thrombocytopenia in these patients. Moreover, these studies provide additional evidence that platelet-type and type IIB v

  1. A family of generalized quantum entropies: definition and properties

    NASA Astrophysics Data System (ADS)

    Bosyk, G. M.; Zozor, S.; Holik, F.; Portesi, M.; Lamberti, P. W.

    2016-08-01

    We present a quantum version of the generalized (h,φ )-entropies, introduced by Salicrú et al. for the study of classical probability distributions. We establish their basic properties and show that already known quantum entropies such as von Neumann, and quantum versions of Rényi, Tsallis, and unified entropies, constitute particular classes of the present general quantum Salicrú form. We exhibit that majorization plays a key role in explaining most of their common features. We give a characterization of the quantum (h,φ )-entropies under the action of quantum operations and study their properties for composite systems. We apply these generalized entropies to the problem of detection of quantum entanglement and introduce a discussion on possible generalized conditional entropies as well.

  2. Test of Von Baer's law of the conservation of early development.

    PubMed

    Poe, Steven

    2006-11-01

    One of the oldest and most pervasive ideas in comparative embryology is the perceived evolutionary conservation of early ontogeny relative to late ontogeny. Karl Von Baer first noted the similarity of early ontogeny across taxa, and Ernst Haeckel and Charles Darwin gave evolutionary interpretation to this phenomenon. In spite of a resurgence of interest in comparative embryology and the development of mechanistic explanations for Von Baer's law, the pattern itself has been largely untested. Here, I use statistical phylogenetic approaches to show that Von Baer's law is an unnecessarily complex explanation of the patterns of ontogenetic timing in several clades of vertebrates. Von Baer's law suggests a positive correlation between ontogenetic time and amount of evolutionary change. I compare ranked position in ontogeny to frequency of evolutionary change in rank for developmental events and find that these measures are not correlated, thus failing to support Von Baer's model. An alternative model that postulates that small changes in ontogenetic rank are evolutionarily easier than large changes is tentatively supported. PMID:17236417

  3. [A case of chronic inflammatory demyelinating polyradiculoneuropathy concomitant with acquired von Willebrand syndrome].

    PubMed

    Ueda, Maki; Kawamura, Nobutoshi; Tateishi, Takahisa; Shigeto, Hiroshi; Ohyagi, Yasumasa; Kira, Jun-ichi

    2011-05-01

    We report a case of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) concomitant with acquired von Willebrand syndrome. A 33-year-old man developed motor and sensory polyneuropathy with electrophysiological conduction slowing. At this time, M-protein was absent He was diagnosed with CIDP and received intravenous immunoglobulin and subsequent oral corticosteroids, which resulted in almost complete remission for over 10 years. At the age of 44, he presented with chronic anemia. Laboratory tests and colonoscopy revealed that he had acquired von Willebrand syndrome with monoclonal gammopathy of undetermined significance (IgG lambda type) and colon cancer. Bleeding symptoms were.resolved with intravenous immunoglobulin, but not with supplementation of factor VIII. Shortly after successful excision of the cancer, CIDP and acquired von Willebrand syndrome simultaneously recurred. Intravenous immunoglobulin produced rapid improvement of both neurological and hematological abnormalities. Concurring CIDP and acquired von Willebrand syndrome in the present case may indicate that the conditions have a partly common immunological background including monoclonal gammopathy and a potential common autoantibody-mediated mechanism. Alternatively, dysfunction of von Willebrand factor may increase blood-nerve barrier permeability, inducing the recurrence of CIDP.

  4. Test of Von Baer's law of the conservation of early development.

    PubMed

    Poe, Steven

    2006-11-01

    One of the oldest and most pervasive ideas in comparative embryology is the perceived evolutionary conservation of early ontogeny relative to late ontogeny. Karl Von Baer first noted the similarity of early ontogeny across taxa, and Ernst Haeckel and Charles Darwin gave evolutionary interpretation to this phenomenon. In spite of a resurgence of interest in comparative embryology and the development of mechanistic explanations for Von Baer's law, the pattern itself has been largely untested. Here, I use statistical phylogenetic approaches to show that Von Baer's law is an unnecessarily complex explanation of the patterns of ontogenetic timing in several clades of vertebrates. Von Baer's law suggests a positive correlation between ontogenetic time and amount of evolutionary change. I compare ranked position in ontogeny to frequency of evolutionary change in rank for developmental events and find that these measures are not correlated, thus failing to support Von Baer's model. An alternative model that postulates that small changes in ontogenetic rank are evolutionarily easier than large changes is tentatively supported.

  5. Pattern Formation in Diffusion Flames Embedded in von Karman Swirling Flows

    NASA Technical Reports Server (NTRS)

    Nayagam, Vedha

    2006-01-01

    Pattern formation is observed in nature in many so-called excitable systems that can support wave propagation. It is well-known in the field of combustion that premixed flames can exhibit patterns through differential diffusion mechanism between heat and mass. However, in the case of diffusion flames where fuel and oxidizer are separated initially there have been only a few observations of pattern formation. It is generally perceived that since diffusion flames do not possess an inherent propagation speed they are static and do not form patterns. But in diffusion flames close to their extinction local quenching can occur and produce flame edges which can propagate along stoichiometric surfaces. Recently, we reported experimental observations of rotating spiral flame edges during near-limit combustion of a downward-facing polymethylmethacrylate disk spinning in quiescent air. These spiral flames, though short-lived, exhibited many similarities to patterns commonly found in quiescent excitable media including compound tip meandering motion. Flame disks that grow or shrink with time depending on the rotational speed and in-depth heat loss history of the fuel disk have also been reported. One of the limitations of studying flame patterns with solid fuels is that steady-state conditions cannot be achieved in air at normal atmospheric pressure for experimentally reasonable fuel thickness. As a means to reproduce the flame patterns observed earlier with solid fuels, but under steady-state conditions, we have designed and built a rotating, porous-disk burner through which gaseous fuels can be injected and burned as diffusion flames. The rotating porous disk generates a flow of air toward the disk by a viscous pumping action, generating what is called the von K rm n boundary layer which is of constant thickness over the entire burner disk. In this note we present a map of the various dynamic flame patterns observed during the combustion of methane in air as a function of

  6. BOOK REVIEW: Meilensteine der Astronomie - Von Aristoteles bis Hawking

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Hamel, J.

    2006-12-01

    A writer, more specific a writer on the history of astronomy, might from time to time look at the collected document folders with all the research material and reprints, and might wonder: has this been all? Especially at a time when recycling is in vogue? And, perhaps with a request or an invitation to submit something, he or she might consider re-using the material before its definitive disposal. Well, such are my feelings when I looked at Jurgen Hamel's new book Milestones of Astronomy - From Aristoteles to Hawking . A slight chance for survival of medium-sized publishers like Kosmos is to offer popular books, and a title must attract potential buyers: Aristoteles means the "old" times, and as concerns the "mad scientist" of modern times, Stephen Hawking has by now dethroned Einstein. In 1998, Hamel had published a Geschichte der Astronomie - Von den Anfangen bis zur Gegenwart (History of astronomy, from the beginnings to the present), which, of course, he could not simply copy. This time, he selected some stones from his research areas - milestones, touchstones, stumbling blocks in the long road of astronomical evolution - and put them between the covers of his new book. So let us look at these (mile)stones . The reader is informed about Aristoteles on 2 pages, but his medieval interpreter Johannes de Sacrobosco gets 8 pages! Copernicus' life and achievements are described on 9 pages, closely followed by his devotee and translator Rothmann with 8 pages; Copernicus' contemporary, Peter Apian, however, gets about 13! Bessel's and Herschel's lifes and works are described on well-deserved 13 and 15 pages, while the achievements of the two Lucasian professors, Isaac Newton and Stephen Hawking, are just outlined in a single paragraph! Thus, importance is sometimes inversely proportional to text length... But let us become serious now. Why should an active historian outline, for the hundreth time, the life of Copernicus, while there are so many interesting, and often

  7. Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis

    PubMed Central

    Atanur, Santosh; Musilová, Alena; Zídek, Václav; Saba, Laura; Warnecke, Andreas; Khademi, Mohsen; Studahl, Marie; Aurelius, Elisabeth; Hjalmarsson, Anders; Garcia-Diaz, Ana; Denis, Cécile V.; Bergström, Tomas; Sköldenberg, Birgit; Kockum, Ingrid; Aitman, Timothy; Hübner, Norbert; Olsson, Tomas; Pravenec, Michal; Diez, Margarita

    2016-01-01

    Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain. Although viral latency in neurons is very common in the population, it remains unclear why certain individuals develop HSE. Here we explore potential host genetic variants predisposing to HSE. In order to investigate this we used a rat HSE model comparing the HSE susceptible SHR (Spontaneously Hypertensive Rats) with the asymptomatic infection of BN (Brown Norway). Notably, both strains have HSV-1 spread to the CNS at four days after infection. A genome wide linkage analysis of 29 infected HXB/BXH RILs (recombinant inbred lines—generated from the prior two strains), displayed variable susceptibility to HSE enabling the definition of a significant QTL (quantitative trait locus) named Hse6 towards the end of chromosome 4 (160.89–174Mb) containing the Vwf (von Willebrand factor) gene. This was the only gene in the QTL with both cis-regulation in the brain and included several non-synonymous SNPs (single nucleotide polymorphism). Intriguingly, in human chromosome 12 several SNPs within the intronic region between exon 43 and 44 of the VWF gene were associated with human HSE pathogenesis. In particular, rs917859 is nominally associated with an odds ratio of 1.5 (95% CI 1.11–2.02; p-value = 0.008) after genotyping in 115 HSE cases and 428 controls. Although there are possibly several genetic and environmental factors involved in development of HSE, our study identifies variants of the VWF gene as candidates for susceptibility in experimental and human HSE. PMID:27224245

  8. Effect of von Willebrand factor on clot structure and lysis.

    PubMed

    Marchi, Rita; Rojas, Héctor

    2015-07-01

    Von Willebrand Factor (vWF) is constitutively secreted by the endothelium and incorporated in the fibrin clots under slow clotting conditions. The aim of the present work was to study the effect of vWF on clot structure and lysis. Purified fibrinogen was mixed with vWF or Tris-buffered saline and clotted with thrombin - activated factor XIII. Fibrin polymerization was followed by turbidity at 350 nm during 2.5 h. After this time, plasmin was added on the top of the clots, and the optical density (OD) was read until baseline values. vWF effect on network[Combining Acute Accent]s porosity was evaluated by permeation using the same clotting conditions as for fibrin polymerization. Clot structure was visualized and analyzed by laser scanning confocal microscopy (LSCM). The rate of fibrin polymerization was 1.47 mOD/s in the presence of vWF and 0.5 mOD/s when vWF was not added (P < 0.05). The fibrin lysis rate was approximately four times faster when vWF was added to fibrinogen. The fibrin network porosity was (20.4 ± 1.6) × 10 cm with vWF and (8.3 ± 1.2) × 10 cm without external vWF (P < 0.05). The analysis of LSCM images showed that vWF increased fibrin fibers diameter and the networks[Combining Acute Accent] pores size. In conclusion, vWF covalently crosslinked to fibrin modify its structure (increases fibrin diameter and the pores filling space of the meshwork) that accelerates the fibrin lysis rate.

  9. Philipp Frank, Richard von Mises, and the Frank-Mises

    NASA Astrophysics Data System (ADS)

    Siegmund-Schultze, Reinhard

    2007-01-01

    The theoretical physicist Philipp Frank (1884 1966) and the applied mathematician Richard von Mises (1883 1953) both received their university education in Vienna shortly after 1900 and became friends at the latest during the Great War.They were attached to the Vienna Circle of Logical Positivists and wrote an influential two-part work on the differential and integral equations of mechanics and physics, the Frank-Mises, of 1925 and 1927, with its second edition following in 1930 and 1935.This work originated in the lectures that the mathematician Bernhard Riemann (1826 1866) delivered on partial differential equations and their applications to physical questions at the University of Göttingen between 1854 and 1862, which were edited and published posthumously in1869 by the physicist Karl Hattendorff (1834 1882).The immediate precursor of the Frank-Mises, however, was the extensive revision of Hattendorff’s edition of Riemann’s lectures that the mathematician Heinrich Weber (1842 1913) published in two volumes, the Riemann-Weber, of 1900 and 1901, with its second edition following in 1910 and 1912. I trace this historical lineage, explore the nature and contents of the Frank-Mises, and discuss its complementary relationship to the first volume of the text that the mathematicians Richard Courant (1888 1972) and David Hilbert (1862 1943) published on the methods of mathematical physics in 1924, the Courant-Hilbert,which, when it and its second volume of 1937 were translated into English and extensively revised in 1953 and 1961, eclipsed the classic Frank-Mises.

  10. Von Willebrand factor in the outcome of temporal arteritis.

    PubMed Central

    Cid, M C; Monteagudo, J; Oristrell, J; Vilaseca, J; Pallarés, L; Cervera, R; Font, C; Font, J; Ingelmo, M; Urbano-Márquez, A

    1996-01-01

    OBJECTIVE: To determine fluctuation in circulating von Willebrand factor (vWF) in the outcome of patients with temporal arteritis. METHODS: Plasma vWF antigen concentrations were measured in 65 patients with biopsy proven temporal arteritis at different disease activity stages, in 12 with isolated polymyalgia rheumatica, and in 16 controls. Fourteen temporal arteritis patients underwent serial determinations during the course of their disease. RESULTS: vWF concentrations were significantly raised in temporal arteritis (mean 220 [arbitrary units], range 96 to 720) and in polymyalgia rheumatica (mean 196, range 103 to 266) compared with healthy controls (mean 98, range 75 to 137) (P < 0.05). Although vWF values tended to be higher in temporal arteritis, no significant differences were found between temporal arteritis and polymyalgia rheumatica patients nor between temporal arteritis patients with ischaemic complications (mean 269, range 130 to 720) and those who presented with polymyalgia rheumatica or constitutional symptoms only (mean 179, range 140 to 220). The highest levels were obtained in patients with associated, mainly infectious, diseases (mean 631, range 240 to 1680). Raised vWF values found in active temporal arteritis patients (mean 220, range 96 to 720) persisted within the first two years after the beginning of treatment (mean 244, range 102 to 510) but tended to normalise in patients in long term remission (mean 143, range 50 to 260). CONCLUSIONS: Persistent elevation of vWF during early remission of temporal arteritis might represent an endothelial activation status induced by a remaining inflammatory microenvironment rather than a marker of endothelial cell injury. In long term remission, decreasing vWF concentrations might reflect progression of inflammatory lesions to a healing stage. PMID:9014589

  11. Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis.

    PubMed

    Abdelmagid, Nada; Bereczky-Veress, Biborka; Atanur, Santosh; Musilová, Alena; Zídek, Václav; Saba, Laura; Warnecke, Andreas; Khademi, Mohsen; Studahl, Marie; Aurelius, Elisabeth; Hjalmarsson, Anders; Garcia-Diaz, Ana; Denis, Cécile V; Bergström, Tomas; Sköldenberg, Birgit; Kockum, Ingrid; Aitman, Timothy; Hübner, Norbert; Olsson, Tomas; Pravenec, Michal; Diez, Margarita

    2016-01-01

    Herpes simplex encephalitis (HSE) is a rare complication of Herpes simplex virus type-1 infection. It results in severe parenchymal damage in the brain. Although viral latency in neurons is very common in the population, it remains unclear why certain individuals develop HSE. Here we explore potential host genetic variants predisposing to HSE. In order to investigate this we used a rat HSE model comparing the HSE susceptible SHR (Spontaneously Hypertensive Rats) with the asymptomatic infection of BN (Brown Norway). Notably, both strains have HSV-1 spread to the CNS at four days after infection. A genome wide linkage analysis of 29 infected HXB/BXH RILs (recombinant inbred lines-generated from the prior two strains), displayed variable susceptibility to HSE enabling the definition of a significant QTL (quantitative trait locus) named Hse6 towards the end of chromosome 4 (160.89-174Mb) containing the Vwf (von Willebrand factor) gene. This was the only gene in the QTL with both cis-regulation in the brain and included several non-synonymous SNPs (single nucleotide polymorphism). Intriguingly, in human chromosome 12 several SNPs within the intronic region between exon 43 and 44 of the VWF gene were associated with human HSE pathogenesis. In particular, rs917859 is nominally associated with an odds ratio of 1.5 (95% CI 1.11-2.02; p-value = 0.008) after genotyping in 115 HSE cases and 428 controls. Although there are possibly several genetic and environmental factors involved in development of HSE, our study identifies variants of the VWF gene as candidates for susceptibility in experimental and human HSE.

  12. Evaluation of von Willebrand factor in COPD patients*

    PubMed Central

    Bártholo, Thiago Prudente; da Costa, Cláudia Henrique; Rufino, Rogério

    2014-01-01

    OBJECTIVE: To compare the absolute serum von Willebrand factor (vWF) levels and relative serum vWF activity in patients with clinically stable COPD, smokers without airway obstruction, and healthy never-smokers. METHODS: The study included 57 subjects, in three groups: COPD (n = 36); smoker (n = 12); and control (n = 9). During the selection phase, all participants underwent chest X-rays, spirometry, and blood testing. Absolute serum vWF levels and relative serum vWF activity were obtained by turbidimetry and ELISA, respectively. The modified Medical Research Council scale (cut-off score = 2) was used in order to classify COPD patients as symptomatic or mildly symptomatic/asymptomatic. RESULTS: Absolute vWF levels were significantly lower in the control group than in the smoker and COPD groups: 989 ± 436 pg/mL vs. 2,220 ± 746 pg/mL (p < 0.001) and 1,865 ± 592 pg/mL (p < 0.01). Relative serum vWF activity was significantly higher in the COPD group than in the smoker group (136.7 ± 46.0% vs. 92.8 ± 34.0%; p < 0.05), as well as being significantly higher in the symptomatic COPD subgroup than in the mildly symptomatic/asymptomatic COPD subgroup (154 ± 48% vs. 119 ± 8%; p < 0.05). In all three groups, there was a negative correlation between FEV1 (% of predicted) and relative serum vWF activity (r2 = −0.13; p = 0.009). CONCLUSIONS: Our results suggest that increases in vWF levels and activity contribute to the persistence of systemic inflammation, as well as increasing cardiovascular risk, in COPD patients. PMID:25210959

  13. "'And They Lived Happily Ever After": The Fairy Tale of Radical Constructivism and Von Glasersfeld's Ethical Disengagement

    ERIC Educational Resources Information Center

    d'Agnese, Vasco

    2015-01-01

    Is von Glasersfeld's constructivism actually radical? In this article, I respond to this question by analyzing von Glasersfeld's main works. I argue that the essential theoretical move of radical constructivism--namely the assertion that reality is the construction of a human mind that only responds to the subjective perception of "what…

  14. Freedom and mystery: an intellectual history of Jaspers' General Psychopathology.

    PubMed

    Bormuth, Matthias

    2013-01-01

    The Kantian idea of freedom was introduced to psychiatry methodologically by Karl Jaspers. It influenced the genesis and design of his doctrine of understanding, General Psychopathology, even more decisively than Nietzsche's topos of resentment did. This article places Jaspers' work in the framework of a history of ideas. It begins by pursuing Nietzsche's perspective in the context of Darwinism, then focuses on the role concealed resentment played for Jaspers' genealogical concept of understanding in the first (1913) edition of General Psychopathology, which is primarily oriented towards Max Weber, before examining the idea of Kantian freedom, which was to become crucial for Jaspers' later work. The antinomy of freedom already shapes the suicidology contained in Jaspers' Philosophy of 1931. The idea gains prominence in the final, philosophically grounded revision of GeneralPsychopathology published in 1941/1942. Jaspers' reception of Kantian idealism leads him to develop a concept of critical understanding that clearly distinguishes itself from speculative understanding, whose hazards Jaspers illustrates on the basis of Viktor von Weizsäcker's theory of medicine. This goes far beyond Kant, embracing Schelling and Hegel philosophically. As it were, Jaspers and von Weizsäcker represent critical and postcritical thought in psychopathology and psychosomatics. The epilogue sums up by placing the inquiry in the context of Jaspers' life and work. PMID:23942461

  15. Freedom and mystery: an intellectual history of Jaspers' General Psychopathology.

    PubMed

    Bormuth, Matthias

    2013-01-01

    The Kantian idea of freedom was introduced to psychiatry methodologically by Karl Jaspers. It influenced the genesis and design of his doctrine of understanding, General Psychopathology, even more decisively than Nietzsche's topos of resentment did. This article places Jaspers' work in the framework of a history of ideas. It begins by pursuing Nietzsche's perspective in the context of Darwinism, then focuses on the role concealed resentment played for Jaspers' genealogical concept of understanding in the first (1913) edition of General Psychopathology, which is primarily oriented towards Max Weber, before examining the idea of Kantian freedom, which was to become crucial for Jaspers' later work. The antinomy of freedom already shapes the suicidology contained in Jaspers' Philosophy of 1931. The idea gains prominence in the final, philosophically grounded revision of GeneralPsychopathology published in 1941/1942. Jaspers' reception of Kantian idealism leads him to develop a concept of critical understanding that clearly distinguishes itself from speculative understanding, whose hazards Jaspers illustrates on the basis of Viktor von Weizsäcker's theory of medicine. This goes far beyond Kant, embracing Schelling and Hegel philosophically. As it were, Jaspers and von Weizsäcker represent critical and postcritical thought in psychopathology and psychosomatics. The epilogue sums up by placing the inquiry in the context of Jaspers' life and work.

  16. Estimating the probability distribution of von Mises stress for structures undergoing random excitation. Part 1: Derivation

    SciTech Connect

    Segalman, D.; Reese, G.

    1998-09-01

    The von Mises stress is often used as the metric for evaluating design margins, particularly for structures made of ductile materials. For deterministic loads, both static and dynamic, the calculation of von Mises stress is straightforward, as is the resulting calculation of reliability. For loads modeled as random processes, the task is different; the response to such loads is itself a random process and its properties must be determined in terms of those of both the loads and the system. This has been done in the past by Monte Carlo sampling of numerical realizations that reproduce the second order statistics of the problem. Here, the authors present a method that provides analytic expressions for the probability distributions of von Mises stress which can be evaluated efficiently and with good precision numerically. Further, this new approach has the important advantage of providing the asymptotic properties of the probability distribution.

  17. An Alternative to Von Glasersfeld's Subjectivism in Science Education: Deweyan Social Constructivism

    NASA Astrophysics Data System (ADS)

    Garrison, Jim

    An influential view of constructivism in science and mathematics educational research and practice is that of Ernst von Glasersfeld. It is a peculiarly subjectivist form of constructivism that should not be attractive to science and mathematics educators concerned with retaining some sort of realism that leaves room for objectivity. The subjectivist constructivism of von Glasersfeld also becomes entangled in untenable mind/body and subject/object dualisms. Finally, these dualisms are unnecessary for social constructivism. I will provide one example of a social constructivist alternative to social constructivism, that of the pragmatic philosopher John Dewey. In presenting Dewey's position I will appeal to Ockham's razor, that is, the admonition not to multiply entities beyond necessity, to shave off the needless mentalistic and psychic entities that lead von Glasersfeld into his subjectivism and dualism.

  18. [Viktor Borisovich von Gyubbenet--a military physician, a surgeon and a social activist].

    PubMed

    Ishutin, O S

    2015-02-01

    The current article is dedicated to a talented surgeon, an organizer of military health care, an extraordinary personality and a public figure--Doctor of Medicine, a privy councilor Victor Borisovich von Guebbenet. A talent of von Gyubbenea as a doctor-surgeon and an organizer of the surgical help on theater of war was especially brightly shown during two big military conflicts of the beginning of the XX century--the Russo-Japanese War (1904-1905) and the First World War I (1914-1918). In the first case doctor von Gyubbenet, being a surgeon of the 3rd Siberian corps successfully manage the activity of military-medical divisions and establishments of Port Arthur garrison. In the second military conflict Victor Borisovich as a doctor and an organizer headed sanitary part of armies of the Western front and successfully directed a medical support of armies of the front since 1915 and until the end of war. PMID:25920178

  19. The use of recombinant activated factor VII in congenital and acquired von Willebrand disease.

    PubMed

    Franchini, Massimo; Veneri, Dino; Lippi, Giuseppe

    2006-11-01

    Recombinant activated factor VII (NovoSeven), a novel hemostatic agent originally developed for the treatment of bleeding episodes in hemophilia A or B patients with inhibitors, has been recently employed with benefit for the management of hemorrhages in other nonhemophilic congenital and acquired hemostatic abnormalities. This review focuses on the use of this drug in acquired and congenital von Willebrand disease. The analysis of the literature data shows that recombinant activated factor VII is an effective agent for the treatment of refractory bleeding in von Willebrand disease patients and for the treatment or prevention of bleeding in those patients with alloantibodies or autoantibodies against von Willebrand factor. Further studies are needed, however, to assess its safety and to optimize the dosages and regimens of therapy in such patients.

  20. Hemophilia And Von Willebrand Disease In Children: Emergency Department Evaluation And Management.

    PubMed

    Schwartz, Kevin R; Rubinstein, Max

    2015-09-01

    Hemophilia and von Willebrand disease are the most common inherited bleeding disorders encountered in the emergency department. Evidence suggests that the management of bleeding disorders in the emergency department is currently suboptimal, and literature to guide evaluation and management in this setting is limited, though some guidelines do exist. The emergency clinician must have a high index of suspicion for new diagnoses, particularly in young patients with unprovoked bleeding and children with multiple or severe bleeds. The foundation of hemophilia treatment is urgent clotting factor replacement, with replacement goals guided by the presenting complaint. Bleeding in von Willebrand disease may be treated with products containing von Willebrand factor or with desmopressin. This review focuses on the epidemiology, pathophysiology, common presentations, evaluation strategies, and emergency management of these bleeding disorders.