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Sample records for generals carl von

  1. [Hermann von Helmholtz and Carl Stumpf on consonance and dissonance].

    PubMed

    Kursell, Julia

    2008-06-01

    The article juxtaposes Hermann von Helmholtz's work in the experimental physiology of hearing and Carl Stumpf's tone psychology, focusing on the problem of consonance and dissonance in music. It argues that the experimental set-up plays a major role in the approaches to hearing of both Helmholtz and Stumpf, shaping their redefinition of the musical concepts of consonance and dissonance. Helmholtz, however, explains dissonance as resulting from the beats that are heard when sound waves interfere, while Stumpf explains consonance from the fusion (Verschmelzung) of sounds, noting that two tones, depending on their distance cannot always be recognized as two but are heard as one single tone. Helmholtz's definition of dissonance eventually threatens his own theory of hearing, which is based on the mechanical principle of resonance and considers sound to be composed of sinusoidal waves. Both the physical and the mathematical tools he uses cannot easily be brought into accordance with his experimental findings on beats, which ask for a discrimination of fast changes in intensity. Dissonance thus becomes "unrecomendable" for Helmholtz, because it overstrains the ear. Stumpf's research, in contrast, has its point of departure in the historically given set of intervals and tries to find a principle that would explain this choice. His tests with experimental subjects who have no conscious knowledge of musical harmony and prove incapable to follow or reproduce music reveals to him a difference between the unity and multiplicity of tones.

  2. [Carl Friedrich von Weizsäcker - physicist and philosopher].

    PubMed

    Drieschner, Michael

    2014-01-01

    The subject of this paper is the philosopher Carl Friedrich von weizsäcker, especially under the aspect of the relation between physics and philosophy in his works. The decisive role of time in physics as well as in philosophy is described, and thereof is derived the comprehension of probability as a predicted relative frequency. Consequently quantum mechanics is interpreted as a theory of probability that uses "quantum logic" instead of classical propositional logic that is used in "normal" probability. The philosophical fruit of that is the interpretation of potentiality as the modality of the future. Weizsäcker's proposals for a justification of physics a priori are dealt with as well as his approach to a theory of "ur-objects", which are atoms in the strictest sense: q-bits.--Questions of Weizsäcker's personality are addressed: His role in the development of the nuclear reactor and atomic bomb in Nazi time, his enthusiasm and his religiousness as well as his efforts towards world peace.

  3. [The ambivalence concept by Carl Friedrich von Weizsäcker - attempt at an exegesis].

    PubMed

    Laitko, Hubert

    2014-01-01

    Carl Friedrich von Weizsäcker treated the problematic implications of scientific-technological progress, emerging in the lifetime of his generation, under the key-word "ambivalence". Obviously it means a proto-theoretical, fuzzy concept that cannot be introduced explicitly per definition; starting with an intuitive perception, "ambivalence" should gradually gain meaning by using it in different argumentative contexts. Following a circular course (Kreisgang)--a procedure typical for Weizsäcker's style of thought--, he moves successively from explicit ambivalence in the application sphere of science through ambivalent features in scientists' behaviour and action up to the general ambivalence of human existence, disclosed only at an anthropological level of deliberation. The given paper delineates the ambivalence concept used by Weizsäcker during the 1960s and 1970s.

  4. Werner Heisenberg and Carl Friedrich Freiherr von Weizsäcker: A Fifty-Year Friendship*

    NASA Astrophysics Data System (ADS)

    Cassidy, David C.

    2015-03-01

    This paper follows Werner Heisenberg and Carl Friedrich von Weizsäcker during their fifty-year friendship from 1926, when they first met in Copenhagen, to Heisenberg's death in Munich in 1976. The relationship underwent profound changes during that period, as did physics, philosophy, and German society and politics, all of which exerted important influences on their lives, work, and interactions with each other. The nature of these developments and their impact are explored in this paper.

  5. ["Living with the bomb" - Carl Friedrich von Weizsäcker's path from physics to politics].

    PubMed

    Walker, Mark

    2014-01-01

    Carl Friedrich von Weizsäcker spanned a spectrum from physics to politics, with philosophy in-between. This chapter surveys the most controversial part of his career, including his work on nuclear weapons and participation in cultural propaganda during the Second World War, his subsequent active political engagement during the postwar Federal German Republic, in particular the role of nuclear weapons, and his participation in myths surrounding Hitler's Bomb".

  6. [Carl Friedrich von Weizsäcker's philosophy of the mind].

    PubMed

    Lyre, Holger

    2014-01-01

    The paper deals with Carl Friedrich von Weizsäcker's position within the philosophy of mind. It turns out that Weizsäcker's ontology is based on an unorthodox conception both in the philosophy of physics and in the philosophy of mind. His quantum information theoretic reductionism is based on a subtle combination of atomism and holism, his philosophy of mind connected to this is a neutral monism, which proposes a bold intertwining of mind, matter, and space.

  7. Charles Darwin and other great men in correspondence with Carl Wilhelm von Naegeli.

    PubMed

    Naegeli, W; Wiedemann, H R

    1993-04-15

    The great Swiss-German botanist Carl Wilhelm von Naegeli (1817-1891) was a student of Lorenz Oken, A.P. de Candolle, and Matthias Jacob Schleiden and became a key figure in "genetic" (i.e., evolutionary-developmental) biology in the mid-late 19th century. He was an expert on the hawk-weed, Hieracium and also made important contributions to microbiology. One of his many outstanding students was Carl Correns, one of the 3 rediscoverers of Mendel's work. Naegeli was an early proponent and defender of Darwin. The correspondence preserved in the Naegeli family contains many important letters between Naegeli and his contemporaries. Those from Mendel to Naegeli have passed out of the Naegeli family and were published by Correns earlier in the century. However, exceptionally notable items still in the archives of the Naegeli family include 4 surviving letters from Darwin, 2 letters from Virchow, and 10 from Justus von Liebig. In spite of a lack of appreciation of Mendel's work, we call attention to the importance of those surviving documents from an era in which very few of the greatest naturalists and founders of modern biology--including Goethe, Darwin, Galton, Agassiz, von Humboldt, von Baer--were without "blind spots."

  8. Of all foods bread is the most noble: Carl von Linné (Carl Linneaus) on bread1

    PubMed Central

    Räsänen, Leena

    2007-01-01

    Carl von Linné was interested in dietetics, which in his time covered all aspects of a healthy life. As a utilitarian he understood the importance of private economy and paid attention to bread in many of his publications. Two texts, Ceres noverca arctoum and De pane diaetetico, were wholly devoted to bread and bread-making. Linné classified different types of bread, and described their nutritional value and health-related aspects, as well as milling, baking and storing, in detail. While discussing the food habits of social classes Linné accepted as a fact that the peasants and the poor should eat less tasty bread than the rich. The less palatable bread had, however, many nutritional and health advantages. Linné paid much attention to substitutes for grain to be used in times of famine, an important topic in eighteenth century Sweden. He regarded flour made of pine bark or water arum roots as excellent famine food, was enthusiastic about the new plant, maize, but considered potato only as a poor substitute for grain. Linné and his followers praised bread not only as the core component of diet, but also for its versatile role both in health and in disease.

  9. [Carl Friedrich von Weizsäcker: nuclear disarmament and the search for freedom].

    PubMed

    Neuneck, Götz

    2014-01-01

    Carl Friedrich von Weizsäcker's comprehensive contributions to nuclear disarmament and arms control, as well as his peace policy impulses are to be understood primarily in the context of his family origin, his comprehensive thinking and the historical circumstances of the emerging nuclear age. They have a scientific, political and a strong philosophical-moral component. Beside the factual problems (nuclear energy, military strategy) he was interested in political power issues and their ambivalence and perception. His actual work is not only based on general academic knowledge, but also serve the immediate political influence on a scientific basis. Weizsäcker was not committed to nuclear disarmament or arms control per se, but about creating a lasting peace policy in the nuclear age. The paper discusses in chronological order of Weizsäcker's work within the policy field peace and disarmament. Family origin, study and work on the nuclear programme by Nazi-Germany laid the foundations for his later career. As a young physicist, he was directly involved in the political and ethical dilemma of the military and civilian use of nuclear energy. After the war, in Göttingen and Hamburg the reflections of the Nazi phase and the discussion of ways out of the dangers of the Cold War followed. The Max-Planck Institute in Starnberg dealt with the science-based treatment of global world problems, including the dangers of nuclear proliferation. Finally, Weizsäcker initiated a Peace Council in 1985. He urged both the perception of the moral responsibility of scientists as well as an ethics of the scientific-technological age. According to him, a general and profound change in the consciousness of humankind is needed to solve the existing power problems and the problem of war.

  10. [Encounters and re-encounters - philosophy and religion of the physicist Carl Friedrich von Weizsäcker].

    PubMed

    Meyer-Abich, Michael

    2014-01-01

    (1) Quantum theory deals not just with reality but with the physical (scientific) reality of its objects. Carl Friedrich von Weizsäcker understood this to imply that scientific knowledge of objects converges with philosophical knowledge of their objectivity but did not succeed in rounding off physics. (2) We are actors as well as spectators not only in scientific knowledge but in political processes as well, particularly by means of science. It is, therefore, not justified to deny political responsibility even in 'basic research'. Carl Friedrich von Weizsacker identified classical physics as the venture of knowledge without love but believed that this boundary could be transcended. The apparent neutrality of science must not be tolerated by the churches, however. (3) In religion Weizsäcker felt most at home in Buddhist spirituality, this being akin to Christian spirituality which has been more or less lost by the Christian churches. Yet he tried to support his church and to participate in its actions. (4) Lack of love corresponds to an excess of power in the religious critique of science. In both respects Weizsäcker presented the mirror to industrial society but people in general did not recognize their image. The Max-Planck-Society, however, shut up Weizsäcker's "Institute for the study of the conditions of life in the modern world" (Starnberg 1970-1980) as soon as possible. (5) Weizsäcker always refrained from exerting any power except that of reason or truth. According to Lao Tse this is the power least perceived as such. In politics he generally followed the mainstream after once having been tempted to action in 1941/42. His influence on German society was based on his charismatic spirituality.

  11. [Carl Friedrich von Weizsäcker's design of a unity of physics].

    PubMed

    Görnitz, Thomas

    2014-01-01

    As I learned in many conversations with Carl Friedrich von Weizsäcker, he saw his place in the history of science deriving from his "Theory of Urs". This theory will establish the unity of science on the basis of quantum bits. Any attempts to find some "fundamental bricks"--of whatever kind--must fail because of the antinomies of atomism. An abstract quantum bit is a structure quantum that cannot be conceived as a particle in space and time. However, it is clear, solely for logical reasons, that a quantum bit is an ultimate and indecomposable entity. Weizsäcker's revolutionary goal was--already 50 years ago--to unite quantum theory with cosmology and, on these grounds, proceed to a theory of elementary particles. The article gives a short overview of Weizsäcker's approach to the unity of physics, ending with a brief summary of what has been achieved in that endeavour up to now.

  12. [Carl Friedrich von Weizsäcker and the Bethe-Weizsäcker cycle].

    PubMed

    Wiescher, Michael

    2014-01-01

    The Carbon- or Bethe-Weizsäcker Cycle plays an important role in astrophysics as one of the most important energy sources for a quiescent and explosive hydrogen burning in stars. This paper presents the historical background and the contributions by Carl Friedrich von Weizsäcker and Hans Bethe who provided the first predictions of the cycle. Furthermore, it discussed the experimental verification of the predicted process in the following decades. Also discussed is the extension of the initial Carbon cycle to the CNO multi-cycles and the hot CNO cycles which followed from the detailed experimental studies of the associated nuclear reactions. Finally discussed is the impact of the experimental and theoretical results on our present understanding of hydrogen burning in different stellar environments and on our understanding of the chemical evolution of our universe.

  13. [Carl Friedrich von Weizsäcker and the interpretations of quantum theory].

    PubMed

    Stöckler, Manfred

    2014-01-01

    What are 'interpretations' of quantum theory? What are the differences between Carl Friedrich von Weizsäkcker's approach and contemporary views? The various interpretations of quantum mechanics give diverse answers to questions concerning the relation between measuring process and standard time development, the embedding of quantum objects in space ('wave-particle-dualism'), and the reference of state vectors. Does the wave function describe states in the real world or does it refer to our knowledge about nature? First, some relevant conceptions in Weizsäcker's book The Structure of Physics (Der Aufbau der Physik, 1985) are introduced. In a second step I point out why his approach is not any longer present in contemporary debates. One reason is that Weizsäcker is mainly affected by classical philosophy (Platon, Aristoteles, Kant). He could not esteem the philosophy of science that was developed in the spirit of logical empiricism. So he lost interest in disputes with Anglo-Saxon philosophy of quantum mechanics. Especially his interpretation of probability and his analysis of the collapse of the state function as change in knowledge differ from contemporary standard views. In recent years, however, epistemic interpretations of quantum mechanics are proposed that share some of Weizsäcker's intuitions.

  14. [A failed experiment - Carl Friedrich von Weizsäcker, Jürgen Habermas and the Max-Planck Society].

    PubMed

    Leendertz, Ariane

    2014-01-01

    From 1970 to 1980 Carl Friedrich von Weizsäcker headed the Max-Planck-lnstitut zur Erforschung der Lebensbedingungen der wissenschaftlich-technischen Welt (MPI for the study of the living conditions of the world of science and technology) in Starnberg, jointly with Jürgen Habermas since 1971. From the start, the Max Planck Society regarded the new institute as an experiment that might perhaps be aborted a few years later. This is exactly what happened. With the retirement of Weizsäcker, his section was closed and the whole institute was renamed. In 1981. Habermas resigned, and then the institute was closed. This paper focusses on some of the problem constellations within the institute that partly explain its development and eventual closure: its birth out of the idea of scientific policy advice, the debates within the Max Planck Society and the complex relationship between Weizsäcker and Jürgen Habermas.

  15. Carl von Rokitansky and the Italian translation of the Handbuch der Pathologischen Anatomie: a linguistic and doctrinal enigma.

    PubMed

    Castagnoli, L; Jonjic, N; Rizzardi, C; Melato, M

    2001-12-01

    Carl von Rokitansky was the author of a treatise that came out between 1842 and 1846 with the title Handbuch der Pathologischen Anatomie. A historical milestone in pathological anatomy, Rokitansky's work represented the first attempt to systematically classify pathological specimens. Its publication inevitably made a great impact on Vienna, at that time the major European medical centre. The Italian translation of Rokitansky's masterpiece, Trattato Completo di Anatomia Patologica, published in Venice in 1852, was carried out by Ricchetti and Fano: the former a philologist and the latter a Triestine physician who, in 1873, had worked at Simon Pertot's side, the first prosector to be assumed in Trieste. From the start, the two translators not only made no secret of the linguistic obstacles they came up against, but also how unconvincing Rokitansky's doctrines were; a scepticism emerged from their words that inevitably contributed to the realization of a translation difficult to read. Undoubtedly, Rokitansky elaborated a theory of disease containing a certain degree of unclarity and in this respect it is interesting to emphasize that even the English translation, Manual of Pathologic Anatomy (1849-1854), demonstrated similar conceptual problems. A convinced supporter of gross pathology, Rokitansky put forth a theory of disease, the so-called Krasenlehre, resting upon humoral doctrines. This new knowledge inevitably exerted a great influence over Viennese, as well as German, medicine. Rokitansky's humoral pathology survived until the 1850s, when it was attacked by young Virchow, the future, universally recognized, father of cellular pathology, who definitively extinguished speculative humoral pathology.

  16. [A utopian episode - Carl Friedrich von Weizsäcker in the networks of the Max-Planck Society].

    PubMed

    Kant, Horst; Renn, Jürgen

    2014-01-01

    Carl Friedrich von Weizsäcker was a key figure in the history of the Max Planck Society (MPS). This essay contextualises his work with the development of the MPS, highlighting the institutional and personal networks upon which it was based. Some of the stations addressed in the following are his role in the German Uranium Project, in preparing the Mainau Declaration, the Göttingen Manifesto, and the Memorandum of Tübingen as well as his involvement in the foundation of the Max Planck Institute (MPI) for Human Development and his own MPI for the Research of Living Conditions in the Modern World located in Starnberg. The relationship between Weizsäcker and Hellmut Becker, long-time friend and founding director of the MPI for Human Development, will be of particular interest. Another issue broached here is the connection between natural science and the humanities in Weizsäcker's work, and subsequently the relation between these two science cultures in the MPS. Finally, we look at the challenges Weizsäcker's work could present to the MPS today.

  17. [Living with responsibility: Max Born and Carl Friedrich von Weizsäcker as philosophers with distance].

    PubMed

    Schirrmacher, Arne

    2014-01-01

    Both Carl Friedrich von Weizsäcker und Max Born belong to the most active scientists, which have raised their voice for peace in the 1950s. While Born, senior to Weizsäcker by one generation, engaged in peace movements at an early stage, which was also due to his emigration, and was a driving force for the Einstein-Russell memorandum, Weizsäcker entered the stage essentially with the Göttingen declaration but quickly dominated the discourse. The comparison of their different engagements for peace sheds new light on Weizsäcker. Unlike the German emigrant with a British passport, who was mainly influenced by EInstein and Russell as well as some socialist thoughts he had encountered at an early age, the son of a noble diplomat and the physicist, who was saved from military duties because of his work in the German wartime nuclear project, had quite a different perspective on the postwar atomic threat. The relation of Born and Weizsäcker remained marked by a certain distance even when both took up very similar roles of 'public scientists' active for peace, be it as delegates at Pugwash conferences, on the air, or as speakers in the Frankfurt Paulskirche.

  18. [Living without atomic power? Carl Friedrich von Weizsäcker as expert in the nuclear energy debate of the 1970's].

    PubMed

    Seefried, Elke

    2014-01-01

    Carl Friedrich von Weizsäcker crossed the boundaries separating science, politics and the public sphere. In this he was led by the conviction that scientists in the modern 'technical age' are responsible for consequences resulting from their applied knowledge. Weizsäcker tried to introduce his knowledge into the policy process by advising politicians or by using the public sphere, thus applying pressure on politics. This was not only true for the 'Göttinger Erklärung' in 1957 but also for his engagement in the nuclear energy debate of the 1970s. Influenced by the 'Limits to Growth' discourse, Weizsäcker more and more gravitated towards an ecological world view and increasingly questioned material growth as well as a techno-scientific based understanding of progress. Weizsäcker thought about risks of the technical age in general and of the use of nuclear energy in particular. In the light of a growing fragmentation of scientific authority, Weizsäcker revealed uncertainty as he became fully aware that expertise cannot be based on scientific reason and cannot code the problems in terms of truth, but is inextricably linked with value spheres and contingencies. Nevertheless, his expertise was utilized as he encouraged parts of the Social Democratic Party (SPD) around Erhard Eppler to think about alternatives in energy policy.

  19. ["World domestic policy" as a way to eternal peace? Carl Friedrich von Weizsäcker's realistic idealism as theory of a sustainable policy].

    PubMed

    Bartosch, Ulrich

    2014-01-01

    The intention of this article is to show the suitability of "Weltinnenpolitik" (world domestic policy) as an analytic and programmatic view on contemporary policy. A full reconstruction or comparison of Carl Friedrich von Weizsäcker's concept is not at the focus. As mentioned in other contributions to this volume, Weizsäcker did not refer to the disciplinary discourses in detail. His approach is particularly 'unique' since he set about in 1963 to study the conditions of peace in a very general way. By doing so, he was able to circumscribe the conditions of peace realistically: those valid for us today and apparently also in the future. Weizsäcker probably did underestimate the complexity of the transformation to sustainable politics for preventing climate change. Vice versa one should hope that we today do not discount the prevention of atomic war as a sine qua non for sustainable climate-saving policy. Both could mark the quintessential conditions for peace.

  20. [The alphabet of nature and the alphabet of culture in the eighteenth century. botany, diplomatics, and ethno-linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner : Botany, Diplomatics, and ethno-linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner].

    PubMed

    Gierl, Martin

    2010-01-01

    In the middle of the eighteenth century, Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner attempted to realize the old idea of deciphering the alphabet of the world, which Francis Bacon had raised as a general postulate of science. This article describes these attempts and their interrelations. Linné used the model of the alphabet to classify plants according to the characters of this fruiting body. Gatterer, one of the leading German historians during the Enlightenment, adopted the botanical method of classification by genus and species to classify the history of scripts. He used the forms of the alphabetic characters to measure the age of manuscripts and to map the process of history as a genealogy of culture. Gatterer collaborated closely with Büttner, the first Göttingen professor of natural history. Büttner constructed a general alphabet of languages which connected the phonetics of language with the historically known alphabets. Early on, diplomatics and ethnography combined the natural order of natural history and the cultural order of the alphabet with the attempt to register development and to document development by the evolution of forms. Based on the shared model of the alphabet and on the common necessity to classify their empirical material, natural history and the description of culture were related attempts in the middle of the eighteenth century to comprehend the alphabetically organized nature and a naturally ordered culture.

  1. Analysis and Comparison of the Ideas and Later Influences of Henri Jomini and Carl von Clausewitz

    DTIC Science & Technology

    1985-04-01

    et imes is necessary. FII * The French Revolution, which marked an end to feudal oppres- sion and despotism in France, began with the fall of ti...8217 Bastille on July 14, 1789. The people organized a constitutional govern- ment with a National Assembly in control. Louis XVI, the French King, retained...can never really foresee--combine to lower the general level of perform- ance so that one always falls far short of the intended goal. . . . Friction

  2. ["The hard core". Science between politics and philosophy by Carl Friedrich von Weizsäcker and in the finalization theory].

    PubMed

    Krohn, Wolfgang

    2014-01-01

    In the Starnberg Max-Planck Institute one of the working groups was concerned with science as the formative condition--or "hard core"--of societal modernity, and with science as potential resource for solving social problems and addressing future goals. More precisely, the group intended to differentiate between phases in which scientific disciplines predominantly care for their own paradigmatic completion and those allowing their theoretical potential resonate with external needs. The conceptual model was coined "finalization in science". It soon provoked a heated controversy on the dangers of social control of science. The paper analyses Carl Friedrich von Weizsäcker's views on the relation between philosophy and policy of science including his interpretation of Thomas Kuhn and reconstructs the impact of his ideas on the finalization model. It finally reflects on the relationship between science development and change of consciousness in the context of scientific responsibility for (the use of) research outcomes.

  3. [The "utopian" national socialism - a mutual dispute in the philosophy of Martin Heidegger and Carl Friedrich von Weizsäcker?].

    PubMed

    Schäfer, Wolf

    2014-01-01

    In a letter to his wife from October 14, 1943, Werner Heisenberg describes a fierce clash with Carl Friedrich von Weizsäcker. The sudden conflict raises numerous questions, two of which are tackled here. First: How is now the friendly relationship between Heisenberg and Weizsäcker in the postwar years to be understood? The answer is: as a strategic performance. Second: How are the radical opinions to be explained that Weizsäcker expressed at the time? A thorough reconstruction of the lifelong connection that Weizsäcker maintained with Martin Heidegger and Heidegger's philosophy gives the answer: the young Weizsäcker was fired up by the "utopian" National Socialism with which Heidegger trumped the real existing.

  4. Carl Friedrich Gauss - General Theory of Terrestrial Magnetism - a revised translation of the German text

    NASA Astrophysics Data System (ADS)

    Glassmeier, K.-H.; Tsurutani, B. T.

    2014-02-01

    This is a translation of the Allgemeine Theorie des Erdmagnetismus published by Carl Friedrich Gauss in 1839 in the Resultate aus den Beobachtungen des Magnetischen Vereins im Jahre 1838. The current translation is based on an earlier translation by Elizabeth Juliana Sabine published in 1841. This earlier translation has been revised, corrected, and extended. Numerous biographical comments on the scientists named in the original text have been added as well as further information on the observational material used by Carl Friedrich Gauss. An attempt is made to provide a readable text to a wider scientific community, a text laying the foundation of today's understanding of planetary magnetic fields.

  5. From the classical to the generalized von Karman and Marguerre-von Karman equations

    NASA Astrophysics Data System (ADS)

    Ciarlet, Philippe G.; Gratie, Liliana

    2006-06-01

    In this work, we describe and analyze two models that were recently proposed for modeling generalized von Karman plates and generalized Marguerre-von Karman shallow shells.First, we briefly review the "classical" von Karman and Marguerre-von Karman equations, their physical meaning, and their mathematical justification. We then consider the more general situation where only a portion of the lateral face of a nonlinearly elastic plate or shallow shell is subjected to boundary conditions of von Karman type, while the remaining portion is free. Using techniques from formal asymptotic analysis, we obtain in each case a two-dimensional boundary value problem that is analogous to, but is more general than, the classical equations.In particular, it is remarkable that the boundary conditions for the Airy function can still be determined on the entire boundary of the nonlinearly elastic plate or shallow shell solely from the data.Following recent joint works, we then reduce these more general equations to a single "cubic" operator equation, which generalizes an equation introduced by Berger and Fife, and whose sole unknown is the vertical displacement of the shell. We next adapt an elegant compactness method due to Lions for establishing the existence of a solution to this operator equation.

  6. The Alphabet of Nature and the Alphabet of Culture in the Eighteenth Century. Botany, Diplomatics, and Ethno-Linguistics according to Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner

    PubMed Central

    2010-01-01

    In the middle of the eighteenth century, Carl von Linné, Johann Christoph Gatterer, and Christian Wilhelm Büttner attempted to realize the old idea of deciphering the alphabet of the world, which Francis Bacon had raised as a general postulate of science. This article describes these attempts and their interrelations. Linné used the model of the alphabet to classify plants according to the characters of this fruiting body. Gatterer, one of the leading German historians during the Enlightenment, adopted the botanical method of classification by genus and species to classify the history of scripts. He used the forms of the alphabetic characters to measure the age of manuscripts and to map the process of history as a genealogy of culture. Gatterer collaborated closely with Büttner, the first Göttingen professor of natural history. Büttner constructed a general alphabet of languages which connected the phonetics of language with the historically known alphabets. Early on, diplomatics and ethnography combined the natural order of natural history and the cultural order of the alphabet with the attempt to register development and to document development by the evolution of forms. Based on the shared model of the alphabet and on the common necessity to classify their empirical material, natural history and the description of culture were related attempts in the middle of the eighteenth century to comprehend the alphabetically organized nature and a naturally ordered culture. PMID:20665241

  7. Carl Sagan Cosmos Voyager

    NASA Video Gallery

    Excerpt from "Cosmos", read by Carl Sagan, part of the NASA.gov multimedia piece celebrating NASA's 50th anniversary in 2008. Used by permission of Carl Sagan Associates. To see the whole interacti...

  8. [From "physical idealist" to "freedom fighter". The change in the perception of Carl Friedrich von Weizsäcker in the DDR - exemplified by honorary doctorate and the Leipzig Colloquium 1987/88].

    PubMed

    Ackermann, Peter

    2014-01-01

    This article draws a representative picture of the official public perception of Carl Friedrich von Weizsäcker in the GDR. In the beginning Weizsäcker served as a classic example of a successful scientist with bourgeois philosophical ideas. So he was often a target of philosophical criticism. This changed with Weizsäcker's activities in peace studies, and the official GDR made an attempt to monopolize him. This could be seen, for example, in connection with his honorary doctorate awarded by the University of Leipzig in 1987 and with the scientific colloquium in 1988. From these examples we can also see that efforts took place to change the focus towards his physical und philosophical achievements. Weizsäcker's official recognition was also helpful for other activities in which he played a leading role. The article looks behind the scenes of a part of the academic machinery in the GDR. It shows that CFvW was an eminent stimulator also in the GDR.

  9. Stochastic resonance in a generalized Von Foerster population growth model

    SciTech Connect

    Lumi, N.; Mankin, R.

    2014-11-12

    The stochastic dynamics of a population growth model, similar to the Von Foerster model for human population, is studied. The influence of fluctuating environment on the carrying capacity is modeled as a multiplicative dichotomous noise. It is established that an interplay between nonlinearity and environmental fluctuations can cause single unidirectional discontinuous transitions of the mean population size versus the noise amplitude, i.e., an increase of noise amplitude can induce a jump from a state with a moderate number of individuals to that with a very large number, while by decreasing the noise amplitude an opposite transition cannot be effected. An analytical expression of the mean escape time for such transitions is found. Particularly, it is shown that the mean transition time exhibits a strong minimum at intermediate values of noise correlation time, i.e., the phenomenon of stochastic resonance occurs. Applications of the results in ecology are also discussed.

  10. [Carl Friedrich von Weizsäcker - supporter of the concept of the East German movement in favor of self-organization during the political turning point 1989/90].

    PubMed

    Gebhardt, Gerd

    2014-01-01

    The luminosity of Carl Friedrich von Weizsäcker's holistic thinking in the former German Democratic Republic (DDR) is reviewed. Broad-minded academics sought, in accordance with the modern paradigm of self-organization, beyond the ideological template for ways out of the dead end of incrustations of society and innovation blockages under the constraints of a dictatorship. Right after the fall of the wall, Weizsäcker willingly backed a "community of free researchers for self-organization" (Freie Forschungsgemeinschaft Selbstorganisation, FFGSO). This group, conceived as a nonpartisan "think tank" of civil activism, is also discussed. At a number of its meetings Weizsäcker debated the dangers of ideologically influenced science. The effectiveness of the dual leadership at his own Starnberg Institute, for instance, was stymied by the tensions arisen out of such conflicting aims. Against the voluntaristic anticipations of the mainstream in sociology, precisely that system proved to be more viable that was meant to be overcome: faulty and purportedly futureless capitalism. Weizsäcker repudiated social prognoses made in the absence of rules for their falsification resp. verification. Weizsäcker acted as a leading figure at the FFGSO's Potsdam conference, opened on 30 Mar. 1990, on the "DDR--and afterwards?". Its intention was in order to trigger a nationwide discussion of scientific scenarios in designing German unification in the face of gross practical disparities between East and West Germany. The Trust Agency inspired by the FFGSO at the Round Table between opposition and old government was supposed to transfer the national public property "Volkseigentum" of the DDR into private property of the East German citizens, to enable them to realize a role as subject through self-organization. At the group's request, Weizsäcker mediated the readiness by the Lutheran World Federation to assume the role of ombudsman in anticipation of conflicts of interest within the

  11. Carl Woese in Schenectady

    PubMed Central

    Gold, Larry

    2014-01-01

    Many of the authors of these short pieces (who were invited to contribute by Robin Gutell) have already written or spoken about Carl Woese since he died at the end of December 2012. My own thoughts were published in PNAS on February 26, 2013. Still saddened by Carl’s death, I re-read what I wrote at that moment. The article was OK, although it was not strong enough for what Carl taught us: he deserved better. I’d like us to admire what Carl did over 50 years (which is a given), and to admire even more the way he did it. While Carl’s accomplishments were huge, his intense dedication to the ideas that consumed him was even more impressive. PMID:24736618

  12. Generalization of von Neumann analysis for a model of two discrete halfspaces : the acoustic case.

    SciTech Connect

    Haney, Matthew M.

    2006-12-01

    Evaluating the performance of finite-difference algorithms typically uses a technique known as von Neumann analysis. For a given algorithm, application of the technique yields both a dispersion relation valid for the discrete time-space grid and a mathematical condition for stability. In practice, a major shortcoming of conventional von Neumann analysis is that it can be applied only to an idealized numerical model - that of an infinite, homogeneous whole space. Experience has shown that numerical instabilities often arise in finite-difference simulations of wave propagation at interfaces with strong material contrasts. These interface instabilities occur even though the conventional von Neumann stability criterion may be satisfied at each point of the numerical model. To address this issue, I generalize von Neumann analysis for a model of two half-spaces. I perform the analysis for the case of acoustic wave propagation using a standard staggered-grid finite-difference numerical scheme. By deriving expressions for the discrete reflection and transmission coefficients, I study under what conditions the discrete reflection and transmission coefficients become unbounded. I find that instabilities encountered in numerical modeling near interfaces with strong material contrasts are linked to these cases and develop a modified stability criterion that takes into account the resulting instabilities. I test and verify the stability criterion by executing a finite-difference algorithm under conditions predicted to be stable and unstable.

  13. Carl Friedrich Gauss

    ERIC Educational Resources Information Center

    Rice, Kathryn; Scott, Paul

    2005-01-01

    This article presents a brief biography of Johann Carl Friedrich Gauss. Gauss was born on April 30, 1777, in the German city of Braunschweig (Brunswick). He was the only child of Gebhard Dietrich Gauss and Dorothea Benze. Neither of Gauss's parents had much education, his father could read and write, but earned his living doing menial jobs such as…

  14. Carl Sagan's Universe

    NASA Astrophysics Data System (ADS)

    Terzian, Yervant; Bilson, Elizabeth

    1997-10-01

    Preface; Carl Sagan at sixty; Part I. Planetary Exploration: 1. On the occasion of Carl Sagan's sixtieth birthday Wesley T. Huntress, Jr.; 2. The search for the origins of life: U.S. Solar system exploration, 1962-1994 Edward C. Stone; 3. Highlights of the Russian planetary program Roald Sageev; 4. From the eyepiece to the footpad: The search for life on Mars Bruce Murray; Part II. Life in the Cosmos: 5. Environments of Earth and other worlds Owen B. Toon; 6. The origin of life in a cosmic context Christopher F. Chyba; 7. Impacts and life: Living in a risky planetary system David Morrison; 8. Extraterrestrial intelligence: The significance of the search Frank D. Drake; 9. Extraterrestrial intelligence: The search programs Paul Horowitz; 10. Do the laws of physics permit wormholes for interstellar travel and machines for time travel? Kip S. Thorne; Public Address: 11. The age of exploration Carl Sagan; Part III. Science Education: 12. Does science need to be popularized? Ann Druyen; 13. Science and pseudo-science James Randi; 14. Science education in a democracy Philip Morrison; 15. The visual presentation of science Jon Lomberg; 16. Science and the press Walter Anderson; 17. Science and teaching Bill G. Aldridge; Part IV. Science, Environment and Public Policy: 18. The relationship of science and power Richard L. Garwin; 19. Nuclear-free world? Georgi Arbatov; 20. Carl Sagan and nuclear winter Richard P. Turco; 21. Public understanding of global climate change James Hansen; 22. Science and religion Joan B. Campbell; 23. Speech in honor of Carl Sagan Frank Press.

  15. A Case of Acute Generalized Pustular Psoriasis of von Zumbusch Triggered by Hypocalcemia

    PubMed Central

    Guerreiro de Moura, Carlos Antônio Gusmão; de Assis, Luiz Henrique; Góes, Paulo; Rosa, Fabiana; Nunes, Victor; Gusmão, Ítalo Magalhães; Cruz, Constança Margarida Sampaio

    2015-01-01

    Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the annular form. GPP may also present severe extracutaneous manifestations including pneumonitis, heart failure and hepatitis. Old reports showed a relationship between hypoparathyroidism and hypocalcemia as triggers for GPP highlighting the importance of adequate workup of the patient and possible therapeutic changes in acute situations. Here, we present a case of severe von Zumbusch psoriasis with life-threatening complications triggered by severe hypocalcemia secondary to hypoparathyroidism successfully treated with aggressive calcium reposition. PMID:26955330

  16. On the history of Ludwig von Bertalanffy's "general systemology", and on its relationship to cybernetics - Part II: Contexts and developments of the systemological hermeneutics instigated by von Bertalanffy

    NASA Astrophysics Data System (ADS)

    Pouvreau, David

    2014-02-01

    The history of "general system theory" is investigated in order to clarify its meanings, vocations, foundations and achievements. It is characterized as the project of a science of the systemic interpretation of the "real", renamed here "general systemology". The contexts and modes of its elaboration, publication and implementation are discussed. The paper mostly focuses on the works of its instigator: Ludwig von Bertalanffy. However, general systemology was a collective project: the main contributions of other "systemologists", from the 1950s until the 1970s, are hence also considered. Its solidarity with the history of the Society for General Systems Research is notably discussed. A reconstruction of the systemological hermeneutics is undertaken on this basis. It finds out the potential systematic unity underlying the diversity of the contributions to this both scientific and philosophical project. Light is thus shed on the actual scope of von Bertalanffy's works.

  17. Carl Rogers: Reflections on His Life.

    ERIC Educational Resources Information Center

    Heppner, P. Paul; And Others

    1984-01-01

    Interviewed Carl Rogers, a prominent psychologist, about aspects of his personal life, professional contributions, significant others, and psychology in general. Includes excerpts from several letters from individuals who have known Rogers and who were asked to comment on their experiences with him. (LLL)

  18. Operational Leadership: A Case of General Helmuth von Moltke (The Younger)

    DTIC Science & Technology

    2007-11-02

    makes his decision too late to have an impact. II. Historical Framework Helmuth Johannes Ludwig von Moltke, known as von Moltke (The Younger) to distin...T. N. Dupuy, A Genius for War (Englewood Cliffs, NJ: Prentis-Hall, Inc. 1977) 140. 1 Otto Friedrich , Blood and Iron: From Bismarck to Hitler the von...Press, 1996) 160. 1 Tuchman, The Guns of August, 73. 1 Friedrich , Blood and Iron, 229. 1 Holmes, “The Schlieffen Plan,” 13. ii

  19. Generalization of von Neumann analysis for a model of two discrete half-spaces: The acoustic case

    USGS Publications Warehouse

    Haney, M.M.

    2007-01-01

    Evaluating the performance of finite-difference algorithms typically uses a technique known as von Neumann analysis. For a given algorithm, application of the technique yields both a dispersion relation valid for the discrete time-space grid and a mathematical condition for stability. In practice, a major shortcoming of conventional von Neumann analysis is that it can be applied only to an idealized numerical model - that of an infinite, homogeneous whole space. Experience has shown that numerical instabilities often arise in finite-difference simulations of wave propagation at interfaces with strong material contrasts. These interface instabilities occur even though the conventional von Neumann stability criterion may be satisfied at each point of the numerical model. To address this issue, I generalize von Neumann analysis for a model of two half-spaces. I perform the analysis for the case of acoustic wave propagation using a standard staggered-grid finite-difference numerical scheme. By deriving expressions for the discrete reflection and transmission coefficients, I study under what conditions the discrete reflection and transmission coefficients become unbounded. I find that instabilities encountered in numerical modeling near interfaces with strong material contrasts are linked to these cases and develop a modified stability criterion that takes into account the resulting instabilities. I test and verify the stability criterion by executing a finite-difference algorithm under conditions predicted to be stable and unstable. ?? 2007 Society of Exploration Geophysicists.

  20. Carl Linnaeus: pictures and propaganda.

    PubMed

    Fara, Patricia

    2003-03-01

    How do scientists become famous? Carl Linnaeus was an expert at self-promotion who used portraits to gain patronage and consolidate his reputation. His sexualized classification system was hugely controversial, yet his successors celebrated him as a great hero of botany.

  1. Carl Sagan (1934-1996)

    NASA Astrophysics Data System (ADS)

    Chyba, Christopher

    Carl Sagan, Professor of Astronomy and Space Sciences at Cornell University and past AGU Planetology Section president, died of pneumonia on December 20, 1996, following a two-year battle with the bone-marrow disease, myelodysplasia. Sagan, a planetary scientist of the first rank, was also well known for his exceptional skills in bringing science to policymakers and the public. Following a broad undergraduate education with a degree in humanities and physics from the University of Chicago, Carl received his Ph.D. in astronomy and astrophysics from that institution in 1960. He quickly established himself as a pioneer in the investigation of the prospect for extraterrestrial life. His wide background in a variety of sciences, including a position as Visiting Assistant Professor of Genetics at the Stanford University School of Medicine, prepared him well for this new, interdisciplinary field. (Carl's first scientific publication, in 1957, had been “Radiation and the origin of the gene,” in the journal Evolution.) In 1968, Carl came to Cornell University as director of the Laboratory for Planetary Studies, heading a research group that combined spacecraft and theoretical expertise with laboratory investigations of solar system and interstellar organic chemistry.

  2. Grandma Moses Meets Eric Carle

    ERIC Educational Resources Information Center

    Sutley, Jane

    2012-01-01

    This activity features artwork by "Grandma Moses" in which children will learn the picture plane in terms of foreground, middle ground, and background. The teacher also introduces the children to Eric Carle's colorful collaged images in his books. Using the two artists' methods, children experimented and invented new techniques and colors. As the…

  3. Acute generalized exanthematous pustulosis x Von Zumbusch’s pustular psoriasis: A diagnostic challenge in a psoriatic patient*

    PubMed Central

    de Sousa, Aline Soares; Lara, Osório Alves Corrêa de Castro; Papaiordanou, Francine; Marchioro, Gláucia Silva Simioni; Tebcherani, Antonio José

    2015-01-01

    Severe cutaneous drug reactions include a wide spectrum of clinical manifestations ranging from mild morbilliform cutaneous rash, to severe forms of hypersensitivity. Special attention is given in this report to the acute generalized exanthematous pustulosis (AGEP), induced in 90% of cases by the use of systemic drugs, especially aminopenicillins and macrolides. The incidence of the disease is low, 1-5 cases per million patients / year. The main differential diagnosis is Von Zumbusch's Pustular Psoriasis. The prognosis is generally good and the disease self limited, after withdrawal of the triggering drug. In this report the authors describe a case of AGEP, triggered by ceftriaxone in a patient with psoriasis vulgaris. PMID:26375226

  4. Carl Neumann's Contributions to Electrodynamics

    NASA Astrophysics Data System (ADS)

    Schlote, Karl-Heinz

    2004-09-01

    I examine the publications of Carl Neumann (1832 1925) on electrodynamics, which constitute a major part of his work and which illuminate his approach to mathematical physics. I show how Neumann contributed to physics at an important stage in its development and how his work led to a polemic with Hermann Helmholtz (1821 1894). Neumann advanced and extended the ideas of the Königsberg school of mathematical physics. His investigations were aimed at founding a mathematically exact physical theory of electrodynamics, following the approach of Carl G.J. Jacobi (1804 1851) on the foundation of a physical theory as outlined in Jacobi’s lectures on analytical mechanics. Neumann’s work also shows how he clung to principles that impeded him in appreciating and developing new ideas such as those on field theory that were proposed by Michael Faraday (1791 1867) and James Clerk Maxwell (1831 1879).

  5. [A tribute to Carl Djerassi].

    PubMed

    Zárate, Arturo; Saucedo, Renata

    2015-01-01

    On January 15, 2015, Carl Djerassi, an extraordinary personality, died at the age of 91 years. He was born in Vienna, Austria, on October 29, 1923. His parents were physicians and probably he wanted to be also a physician, but sooner than later he chose to be a chemist. In 1939 he arrived to live to New York with his mother. In 1945 he became American citizen. Part of his work is the first commercial antihistamine, pyribenzamine, and the first successful combined oral contraceptive pill. With this editorial we make a tribute to this steroid pioneer.

  6. Bragg-von Laue diffraction generalized to twisted X-rays.

    PubMed

    Jüstel, Dominik; Friesecke, Gero; James, Richard D

    2016-03-01

    A pervasive limitation of nearly all practical X-ray methods for the determination of the atomic scale structure of matter is the need to crystallize the molecule, compound or alloy in a sufficiently large (∼ 10 × 10 × 10 µm) periodic array. In this paper an X-ray method applicable to structure determination of some important noncrystalline structures is proposed. It is designed according to a strict mathematical analog of von Laue's method, but replacing the translation group by another symmetry group, and simultaneously replacing plane waves by different exact closed-form solutions of Maxwell's equations. Details are presented for helical structures like carbon nanotubes or filamentous viruses. In computer simulations the accuracy of the determination of structure is shown to be comparable to the periodic case.

  7. [Carl Friedrich von Weizsäcker and Werner Heisenberg].

    PubMed

    Cassidy, David C

    2014-01-01

    The 50-year relationship between Weizsäcker and Heisenberg spanned the highpoints of discovery and dictatorship during the 1930s, extended into the war-time uranium project, the post-war controversy over that project, debates over West German nuclear policy, and the philosophical implications of modern physics. This paper explores the interaction between these two leading figures during that difficult and significant half-century.

  8. Continuity and Schatten-von Neumann p-class membership of Hankel operators with anti-holomorphic symbols on (generalized) Fock spaces

    NASA Astrophysics Data System (ADS)

    Knirsch, Wolfgang; Schneider, Georg

    2006-08-01

    In this paper we investigate Hankel operators with anti-holomorphic symbols , where are general Fock spaces. We will show that is not continuous if the corresponding symbol is not a polynomial . For polynomial symbols we will give necessary and sufficient conditions for continuity and compactness in terms of N and m. For monomials we will give a complete characterization of the Schatten-von Neumann p-class membership for p>0. Namely in case 2kvon Neumann p-class iff p>2m/(m-2k); and in case 2k[greater-or-equal, slanted]m they are not in the Schatten-von Neumann p-class.

  9. Habitat Evaluation Procedures Report; Carl Property - Yakama Nation.

    SciTech Connect

    Ashley, Paul; Muse, Anthony

    2008-02-01

    A baseline habitat evaluation procedures (HEP) analysis was conducted on the Carl property (160 acres) in June 2007 to determine the number of habitat units to credit Bonneville Power Administration (BPA) for providing funds to acquire the property as partial mitigation for habitat losses associated with construction of McNary Dam. HEP surveys also helped assess the general ecological condition of the property. The Carl property appeared damaged from livestock grazing and exhibited a high percentage of invasive forbs. Exotic grasses, while present, did not comprise a large percentage of the available cover in most areas. Cover types were primarily grassland/shrubsteppe with a limited emergent vegetation component. Baseline HEP surveys generated 356.11 HUs or 2.2 HUs per acre. Habitat units were associated with the following HEP models: California quail (47.69 HUs), western meadowlark (114.78 HUs), mallard (131.93 HUs), Canada goose (60.34 HUs), and mink (1.38 HUs).

  10. Menachem's Seed (by Carl Djerassi)

    NASA Astrophysics Data System (ADS)

    Kauffman, George B.; Kauffman, Laurie M.

    1998-09-01

    University of Georgia Press: Athens, GA, 1997. xi +196 pp. 14.2 x 24.0 cm. ISBN 0-8203-1925-2. Hardcover. 21.95. (Coming in paperback, fall 1998. Putnam: New York, 1998. ISBN 0140277943. 12.95.) Carl Djerassi is well known to readers of the Journal of Chemical Education for his pioneering research and as the recipient of numerous awards-including the 1973 U.S. National Medal of Science (for the first oral contraceptive, leading to his designation as "Father of the Pill", although Djerassi, an avowed feminist, prefers the appellation "Mother of the Pill"); the 1991 U.S. National Medal of Technology (for novel approaches to insect control); and the 1992 Priestley Medal (the American Chemical Society's highest award). But he is also founder of the Djerassi Resident Artists Colony, an avid art collector, and Professor of Chemistry at Stanford University. Most pertinent here, after a half-century of dual research careers in industry and academe, Djerassi, like chemist-spectroscopist-novelist C. P. Snow, has embarked on a third career in creative writing, which we have followed in this Journal and others with a mixture of growing interest, admiration, and anticipation (1-5).

  11. [Carl Gustav Jung's alchemical thinking].

    PubMed

    Mirkiewicz, Jakub

    2004-01-01

    Carl Gustav Jung (1875-1961), Swiss psychologist and philosopher of culture used in his concepts many constructs having their source in philosophy of alchemy. These ideas can be found not only in his books on alchemy but also in his psychological works. Among them we should enumerate: the theory of psychological process, the concepts of opposites coexisting in the psyche, the polar structure of notions in his psychological system and the idea of synchronicity. The author of this article examines these main points of Jungian program within the context of its parallelism with paracelsian alchemical philosophy of nature: the process of nature, alchemical dialectics and the universal analogy of micro- and macrocosmos. At the beginning of his work, creating his psychology Jung assumed similar ideas. Later, when he noticed this similarity, alchemy became very helpful in his research of psyche, because thanks to them he conceptualised the successive aspects of polar structure of dynamical psychical reality, which--like his alchemical predecessors--he used to explain basics of the micro- and macro-world.

  12. Lieutenant General "Pete" Quesada and Generalfeldmarschall Wolfram Von Richthofen: What Made Them Great

    DTIC Science & Technology

    2009-06-01

    communicated a more balanced view held by others. Most notable was Air Chief Marshal Sir Arthur William Tedder, Deputy Supreme Commander under General...however long and hard the road may be, for without victory there is no survival. -- Sir Winston Churchill. VICINITY OF ST. LO, FRANCE, 1 AUGUST...he arrived at the 70th Quesada walked up to the wing intelligence officer. Quesada inquired, “What’s the situation?” “Well, sir , at 9 o’clock

  13. What Are They Doing to Carl Rogers?

    ERIC Educational Resources Information Center

    Mader, Diane C.

    1980-01-01

    Notes that recent composition textbooks have classified Carl Rogers' work as a new rhetoric or as an alternative to classical argument. Demonstrates that to portray Rogers' method as a form of argument is to misunderstand his intent and that, while Rogers and Aristotle are similar superficially, their differences are profound. (FL)

  14. Denigrating Carl Rogers: William Coulson's Last Crusade.

    ERIC Educational Resources Information Center

    Kirschenbaum, Howard

    1991-01-01

    Reviews William Coulson's assertions that Carl Rogers, Abraham Maslow, and he initiated the humanistic education field, that Rogers repudiated his philosophy late in life, and that they owe the nation's parents an apology. Argues that these charges are groundless and provides examples and quotations from Rogers' later writings to show how Rogers…

  15. Carl Rogers and Me: Revisiting Teaching.

    ERIC Educational Resources Information Center

    Li, Li-Te

    2003-01-01

    Discusses connections between Carl Rogers and literacy by introducing Rogers' major contributions and by discussing the implementation of his ideas in an English as a Foreign Language (EFL) classroom in Taiwan. Explains Rogers' ideas about teachers as facilitators; learner-centered learning; and building freedom. Concludes that person-centered…

  16. Carl Rogers' Alternative to Traditional Rhetoric.

    ERIC Educational Resources Information Center

    Hairston, Maxine C.

    Carl Rogers' approach to communication has implications for the rhetorician and the teacher of college composition. The qualities of respect, restraint, neutrality, and understanding, when applied to written and oral discourse, can provide an effective alternative to polemical argumentation. The detatchment and empathy of the Rogerian style is…

  17. Eric Carle-Inspired Insect Collages.

    ERIC Educational Resources Information Center

    Palamountain, Eileen; Turner, Kim

    2000-01-01

    Describes a lesson in which students create collage insects inspired by the work of Eric Carle (The Very Hungry Caterpillar). Connects art, language arts, and science. Discusses how students make paper to use as the collage material and how students create the insects. (CMK)

  18. B.F. Skinner and Carl R. Rogers on Behavior and Education.

    ERIC Educational Resources Information Center

    Swaim, Eugene E.

    1972-01-01

    The purpose of this study is to analyze the relationship between the theories of B.F. Skinner and Carl R. Rogers. In sections 2 and 3, the author discusses the Skinnerian and Rogerian theories by selecting and explicating key elements and delineating the general, comprehensive, theoretical position of each. Sections 4 and 5 present each man's…

  19. [Eugen Bleuler and Carl Gustav Jung's habilitation].

    PubMed

    Wilhelm, H R

    1996-01-01

    Eugen Bleuler's letter of recommendation for Carl Gustav Jung's appointment as a lecturer In January 1905, Eugen Bleuler (1857-1939) wrote a letter of recommendation to the Medical Faculty of the University of Zurich, urging them to accept the application of Carl Gustav Jung (1875-1961) as a lecturer there. Bleuler's letter mentions the contribution to Jung's writing made by Franz Riklin (1878-1938), although he does not define it precisely. It is safe to say that, judging from the way in which Bleuler expresses his opinions in this letter, this may be regarded at the very least as an early sign of his receptiveness to the psychoanalytical ideas of the time.

  20. Advanced interferometry at Carl Zeiss (Summary Only)

    NASA Astrophysics Data System (ADS)

    Kuechel, Michael F.

    1992-10-01

    Research at Carl Zeiss has led to some innovative solutions in the field of optical test methods and interferometry. One example is the method of `direct measuring interferometry' (DMI), which was developed to overcome the problems of vibration and air turbulence when testing big astronomical primaries and is now the heart of the Carl Zeiss laser-interferometer DIRECT 100. Since DMI offers real-time capabilities for the wavefront evaluation, a built-in frame-memory can act as an `electronic hologram' and opens very elegant ways for in-situ correction of small residual errors, for easy aspherical testing, a very simple way of two- wavelength-interferometry, or a new discipline of time-resolved interferometry.

  1. Malcolm Knowles and Carl Rogers.

    ERIC Educational Resources Information Center

    Boyer, Dennis L.

    1984-01-01

    The aim of this paper is to examine primary concerns related to the introduction of Knowles's and Rogers's theories of adult education. Comparison of andragogy and student-centered theories includes the following areas: overview, foundations, general goals, learning principles, and teaching and learning and is followed by a summary and…

  2. Expedition 4 Crew Interviews: Carl Walz

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Expedition 4 Flight Engineer Carl Walz is seen during a prelaunch interview. He gives details on the mission's goals and significance, his role in the mission, what his responsibilities will be, what the crew exchange will be like (transferring the Expedition 4 crew in place of the Expedition 3 crew on the International Space Station (ISS)), the day-to-day life on an extended stay mission, the experiments he will be conducting on board, and what the S0 truss will mean to ISS. Walz ends with his thoughts on the short-term and long-term future of the International Space Station.

  3. Frederick Carl Frieseke: The Evolution of an American Impressionist.

    ERIC Educational Resources Information Center

    Johnson, Mark M.

    2002-01-01

    Provides background information on the life and career of Frederick Carl Frieseke, an artist who painted in the style of impressionism. Explains that this artist is the focus of a retrospective exhibition entitled, "Frederick Carl Frieseke: The Evolution of an American Impressionist" at the Telfair Museum of Art (Savannah, Georgia). (CMK)

  4. Dr. Wernher Von Braun with Dr. Christian Barnard.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Christian Barnard Tours Marshall Space Flight Center. Shown in Dr. Von Braun's office are (left to right): Dr. Ernst Sthulinger, a representative from General Electric, Dr. Wernher Von Braun, Dr. Christian Barnard, and Dr. Eberhard Rees.

  5. von Willebrand Disease

    MedlinePlus

    ... from the NHLBI on Twitter. What Is Von Willebrand Disease? Von Willebrand disease (VWD) is a bleeding disorder. ... while hemophilia mainly affects males. Types of von Willebrand Disease The three major types of VWD are called ...

  6. Encountering Carl Rogers: His Views on Facilitating Groups.

    ERIC Educational Resources Information Center

    Landreth, Garry L.

    1984-01-01

    Presents Carl Rogers' views on facilitating groups, as expressed in a telephone dialogue seminar with graduate students in counselor education at North Texas State University. Discusses extended group marathons, cocounseling, nonverbal group exercises and the future of group work. (JAC)

  7. 1. Historic American Buildings Survey, Carl Waite, Photographer September 29, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Carl Waite, Photographer September 29, 1936 SOUTH ELEVATION (TAKEN FROM OLD PHOTOGRAPH). - H. M. Gillette Residence, Route 18, Blue Goose Corners, Wellington, Lorain County, OH

  8. 7. Historic American Buildings Survey Carl Magro, Photographer May 1936, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey Carl Magro, Photographer May 1936, Copied by Joseph Hill. VALVE CONTROL LEVERS ON WEST GATE - Illinois & Michigan Canal, Locks & Lockhouse, Channahon, Will County, IL

  9. 10. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From Mrs. Dwight L. Houghton Collection PORCH DETAIL, EAST ELEVATION, NORTH CORNER. - Britt House, 201 South First Street, Jacksonville, Jackson County, OR

  10. 9. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From Mrs. Dwight L. Houghton Collection CONSERVATORY DETAIL, SOUTH ELEVATION. - Britt House, 201 South First Street, Jacksonville, Jackson County, OR

  11. 8. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From Mrs. Dwight L. Houghton Collection GABLE DETAIL, NORTH ELEVATION. - Britt House, 201 South First Street, Jacksonville, Jackson County, OR

  12. 7. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From Mrs. Dwight L. Houghton Collection GABLE AND ROOF DETAIL, SOUTH ELEVATION. - Britt House, 201 South First Street, Jacksonville, Jackson County, OR

  13. 11. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Historic American Buildings Survey, Carl Landis, Photographer, 1960 From Mrs. Dwight L. Houghton Collection PORCH DETAIL, NORTH ELEVATION. - Britt House, 201 South First Street, Jacksonville, Jackson County, OR

  14. The Face We Put On: Carl Jung for Teachers.

    ERIC Educational Resources Information Center

    Craig, Robert P.

    1994-01-01

    Examines Carl Jung's concept of the "persona" (his term for the masks people wear). Notes how teachers use personae and suggests ways to restore the energy that teachers lose when hiding inside their personae. (SR)

  15. Acute generalized pustular psoriasis, von Zumbusch type, treated in the burn unit. A review of clinical features and new therapeutics.

    PubMed

    Varman, Katherine M; Namias, Nicholas; Schulman, Carl I; Pizano, Louis R

    2014-06-01

    Generalized pustular psoriasis (GPP) is an immune-mediated dermatologic condition that is characterized by a widespread eruption of sterile, subcorneal pustules. Cases of GPP may present to the burn intensive care unit (ICU), and they may be confused with toxic epidermal necrolysis (TEN) due to the generalized erythema and desquamation. GPP often benefits from admission to an ICU for management of fluid and electrolyte imbalances and for complications such as pneumonitis, renal dysfunction and sepsis. We present the case of a 42 year-old man who was transferred to the burn unit for presumed TEN where he was diagnosed with GPP and successfully treated with intravenous cyclosporine and supportive care. Our objective is to increase awareness of this condition in the critical care community, discuss clinical and laboratory findings, and to review the treatment guidelines published by the National Psoriasis Foundation in August 2012. We also discuss the latest reports utilizing biological response modifying drugs.

  16. On the history of Ludwig von Bertalanffy's "General Systemology", and on its relationship to cybernetics - part III: convergences and divergences

    NASA Astrophysics Data System (ADS)

    Drack, Manfred; Pouvreau, David

    2015-07-01

    Bertalanffy's so-called "general system theory" (GST) and cybernetics were and are often confused: this calls for clarification. In this article, Bertalanffy's conceptions and ideas are compared with those developed in cybernetics in order to investigate the differences and convergences. Bertalanffy was concerned with first order cybernetics. Nonetheless, his perspectivist epistemology is also relevant with regard to developments in second order cybernetics, and the latter is therefore also considered to some extent. W. Ross Ashby's important role as mediator between GST and cybernetics is analysed. The respective basic epistemological approaches, scientific approaches and inherent world views are discussed. We underline the complementarity of cybernetic and "organismic" trends in systems research within the unitary hermeneutical framework of "general systemology".

  17. On the history of Ludwig von Bertalanffy's "General Systemology", and on its relationship to cybernetics - part III: convergences and divergences.

    PubMed

    Drack, Manfred; Pouvreau, David

    2015-07-04

    Bertalanffy's so-called "general system theory" (GST) and cybernetics were and are often confused: this calls for clarification. In this article, Bertalanffy's conceptions and ideas are compared with those developed in cybernetics in order to investigate the differences and convergences. Bertalanffy was concerned with first order cybernetics. Nonetheless, his perspectivist epistemology is also relevant with regard to developments in second order cybernetics, and the latter is therefore also considered to some extent. W. Ross Ashby's important role as mediator between GST and cybernetics is analysed. The respective basic epistemological approaches, scientific approaches and inherent world views are discussed. We underline the complementarity of cybernetic and "organismic" trends in systems research within the unitary hermeneutical framework of "general systemology".

  18. The contributions of Carl Ludwig to cardiology.

    PubMed

    Zimmer, H G

    1999-03-01

    The basic instruments for measuring functional cardiovascular parameters and the most important discoveries made by Carl Ludwig and his disciples in cardiovascular physiology are described and put into perspective in regard to the further development of his methods and ideas. The most important apparatus was the kymograph, which, for the first time, made recording and documenting of functional parameters possible. This instrument was also used for the functional evaluation of the isolated perfused frog heart that was developed by Elias Cyon in Ludwig's Leipzig Physiological Institute. In the isolated frog heart, important phenomena were discovered such as the staircase ('Treppe'), the absolute refractory period and the all-or-none law of the heart. The isolated dog heart was used to determine the origin of the first heart sound, which was characterized as a muscle tone. To measure regional blood flow and eventually cardiac output, a flowmeter ('Stromuhr') was designed. Precise measurements of cardiac output became possible only when Adolf Fick had developed his principle, which served as the basis for the modern indicator methods. Cyon and Ludwig also discoverd the depressor nerve, which constitutes the basis of the baroreceptor reflex. Finally, the precise localization of the vasomotor centre in the ventrolateral medulla was achieved in Ludwig's Leipzig Physiological Institute. This was confirmed more than 100 years later with modern neuroanatomical methods making use of retrograde axonal transport. Thus, Ludwig and his scholars made major substantial contributions to cardiovascular knowledge that can be considered to constitute the basis of modern cardiology.

  19. Carl Linnaeus and the visual representation of nature.

    PubMed

    Charmantier, Isabelle

    2011-01-01

    The Swedish naturalist Carl Linnaeus (1707-1778) is reputed to have transformed botanical practice by shunning the process of illustrating plants and relying on the primacy of literary descriptions of plant specimens. Botanists and historians have long debated Linnaeus's capacities as a draftsman. While some of his detailed sketches of plants and insects reveal a sure hand, his more general drawings of landscapes and people seem ill-executed. The overwhelming consensus, based mostly on his Lapland diary (1732), is that Linnaeus could not draw. Little has been said, however, on the role of drawing and other visual representations in Linnaeus's daily work as seen in his other numerous manuscripts. These manuscripts, held mostly at the Linnean Society of London, are peppered with sketches, maps, tables, and diagrams. Reassessing these manuscripts, along with the printed works that also contain illustrations of plant species, shows that Linnaeus's thinking was profoundly visual and that he routinely used visual representational devices in his various publications. This paper aims to explore the full range of visual representations Linnaeus used through his working life, and to reevaluate the epistemological value of visualization in the making of natural knowledge. By analyzing Linnaeus's use of drawings, maps, tables, and diagrams, I will show that he did not, as has been asserted, reduce the discipline of botany to text, and that his visual thinking played a fundamental role in his construction of new systems of classification.

  20. CARL: a LabVIEW 3 computer program for conducting exposure therapy for the treatment of dental injection fear.

    PubMed

    Coldwell, S E; Getz, T; Milgrom, P; Prall, C W; Spadafora, A; Ramsay, D S

    1998-04-01

    This paper describes CARL (Computer Assisted Relaxation Learning), a computerized, exposure-based therapy program for the treatment of dental injection fear. The CARL program operates primarily in two different modes; in vitro, which presents a video-taped exposure hierarchy, and in vivo, which presents scripts for a dentist or hygienist to use while working with a subject. Two additional modes are used to train subjects to use the program and to administer behavioral assessment tests. The program contains five different modules, which function to register a subject, train subjects to use physical and cognitive relaxation techniques, deliver an exposure hierarchy, question subjects about the helpfulness of each of the therapy components, and test for memory effects of anxiolytic medication. Nine subjects have completed the CARL therapy program and 1-yr follow-up as participants in a placebo-controlled clinical trial examining the effects of alprazolam on exposure therapy for dental injection phobia. All nine subjects were able to receive two dental injections, and all reduced their general fear of dental injections. Initial results therefore indicate that the CARL program successfully reduces dental injection fear.

  1. Johann von Lamont: A Pioneer in Geomagnetism

    NASA Astrophysics Data System (ADS)

    Soffel, Heinrich

    2006-06-01

    The 200th birthday of John Lamont (1805-1879, Figure 1), a pioneer in the study of geomagnetism, was marked on 13 December 2005. Lamont founded the Munich Geomagnetic Observatory in 1840 and was a member of the group of scientists including Carl Friedrich Gauss, Alexander von Humboldt, Eduard Sabine, Jonas Angstrøm, Humphret Lloyd, Adolf Kupffer, Karl Kreil, and Adolphe Quetelet who composed the Göttingen Magnetic Union. They organized an international network of geomagnetic observatories [Barraclough et al., 1992]. The present knowledge of the geomagnetic field and its secular variation is largely based on the data collected by the global network of geomagnetic observatories during the last 170 years. Lamont's talents and his dedication and enthusiasm for discovery are reflected in the depth and scope of his contributions to a broad variety of natural sciences such as astronomy, meteorology, geomagnetism, and geodesy. However, this article just touches on his merits in geomagnetism.

  2. Carl Sagan and the Exploration of Mars and Venus

    NASA Technical Reports Server (NTRS)

    Toon, Owen B.; Condon, Estelle P. (Technical Monitor)

    1997-01-01

    Inspired by childhood readings of books by Edgar Rice Burroughs, Carl Sagan's first interest in planetary science focused on Mars and Venus. Typical of much of his career he was skeptical of early views about these planets. Early in this century it was thought that the Martian wave of darkening, a seasonal albedo change on the planet, was biological in origin. He suggested instead that it was due to massive dust storms, as was later shown to be the case. He was the first to recognize that Mars has huge topography gradients across its surface. During the spacecraft era, as ancient river valleys were found on the planet, he directed studies of Mars' ancient climate. He suggested that changes in the planets orbit were involved in climate shifts on Mars, just as they are on Earth. Carl had an early interest in Venus. Contradictory observations led to a controversy about the surface temperature, and Carl was one of the first to recognize that Venus has a massive greenhouse effect at work warming its surface. His work on radiative transfer led to an algorithm that was extensively used by modelers of the Earth's climate and whose derivatives still dominate the calculation of radiative transfer in planetary atmospheres today. Carl inspired a vast number of young scientists through his enthusiasm for new ideas and discoveries, his skeptical approach, and his boundless energy. I had the privilege to work in Carl's laboratory during the peak of the era of Mars' initial exploration. It was an exciting time, and place. Carl made it a wonderful experience.

  3. The Uniqueness of Similarities: Parallels of Milton H. Erickson and Carl Rogers.

    ERIC Educational Resources Information Center

    Gunnison, Hugh

    1985-01-01

    Describes the influence of the philosophy and values of Carl Rogers and Milton Erickson on the counseling profession. Reviews the person-centered approach, direction, therapeutic climate, and the influence of early experiences. Includes a reaction by Carl Rogers. (JAC)

  4. Organelle evolution, fragmented rRNAs, and Carl

    PubMed Central

    Gray, Michael W

    2014-01-01

    I am honored to have been asked to contribute to this memorial issue, although I cannot claim to have known Carl Woese well. Carl’s insights and the discoveries that his research group made over the years certainly stimulated my own research program, and at several points early on, interactions with him were pivotal in my career. Here I comment on these personal dealings with Carl and emphasize his influence in two areas of long-standing interest in my lab: organelle evolution and rRNA evolution. PMID:24572720

  5. Carl R. Rogers (1902-1987): Friend, Gentleman, and Scholar.

    ERIC Educational Resources Information Center

    Van Hesteren, Frank

    1988-01-01

    Writes in memory of Carl R. Rogers. Conveys a sense of the spirit of Rogers' thinking and the kind of person he was, both in his own eyes and in the experience of those who knew him personally. Concludes with a discussion of how Rogers'"way of being" has influenced the writer's own personal and professional development. (Author/KS)

  6. Carl Rogers during Initial Interviews: A Moderate and Consistent Therapist.

    ERIC Educational Resources Information Center

    Edwards, H. P.; And Others

    1982-01-01

    Analyzed two initial interviews by Carl Rogers in their entirety using the Carkhuff scales, Hill's category system, and a brief grammatical analysis to establish the level and consistency with which Rogers provides facilitative conditions. Results indicated his behavior as counselor was stable and consistent within and across interviews. (Author)

  7. 14. Photocopy of photograph (from Carl A. Spier's Souvenir Book ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. Photocopy of photograph (from Carl A. Spier's Souvenir Book of Views, The Ohio Soldiers' and Sailors' Home, Sandusky, Ohio, (Sandusky, Ohio: Alvord & Peters Co.), n.d.) VIEW EAST, NORTHWEST SIDE SHOWING ORIGINAL PORCH, CUPOLA, & WINDOWS - Ohio Soldiers' & Sailors' Home, Cottage L, U.S. Route 250 at DeWitt Avenue, Sandusky, Erie County, OH

  8. Synthesizing a Life: An Interview with Carl Djerassi

    ERIC Educational Resources Information Center

    Cardellini, Liberato

    2011-01-01

    In this interview, Carl Djerassi recalls his first years, from his pleasant childhood, to how he escaped the Nazi persecutions, to his college education in America. He remembers how with his research group he won the race for synthesis of cortisone, and how they then synthesized norethindrone, the active ingredient in oral contraceptives. Djerassi…

  9. Carl Sagan: Cosmic Evolution vs. the Creationist Myth.

    ERIC Educational Resources Information Center

    Harnack, William J.

    1981-01-01

    Considers the dichotomy between the cosmic perspective and the creationist view. Presents an overview of various current explanations of the origin and nature of the universe, including scientific explanations, fundamentalist beliefs, and creation myths from other cultures. The article is based on comments made by Carl Sagan at the American…

  10. Public Information for All: An Interview with Carl Malamud

    ERIC Educational Resources Information Center

    Rabina, Debbie

    2010-01-01

    Since the early 1990s, Carl Malamud has made it his business to return to the public what is rightfully theirs: free access to public information. Despite legislation that mandates such access to government information, some categories of information have been excluded, notable among them court opinions (with the exception of the U.S. Supreme…

  11. Carl Upchurch: Journey from Prisoner Citizen to Educator

    ERIC Educational Resources Information Center

    Kronick, Robert; Thomas, Denis

    2009-01-01

    Carl Upchurch was born and raised in Philadelphia in the 1950's. His mother, uncle and grandmother socialized him during his early childhood. His grandmother was his primary caregiver and a prostitute, his father drifted in and out of his life, and his uncle died in a gunfight. All this shaped Upchurch as a person and led to his development of the…

  12. Re-Discovering Mendel: The Case of Carl Correns

    ERIC Educational Resources Information Center

    Rheinberger, Hans-Jörg

    2015-01-01

    Carl Erich Correns (1864-1933) is remembered in the annals of science as one of the three botanists who re-discovered Mendel's laws. He can also, however, be regarded as one of the founding figures of classical genetics in Germany. Between 1894 and 1899 he carried out the crossing experiments with corn and peas that led to the re-statement of…

  13. The legacy of Carl Vincent Gisolfi in temperature regulation

    PubMed Central

    Tipton, Charles M; Kregel, Kevin C

    2014-01-01

    Carl Vincent Gisolfi (1942–2008) was a Distinguished Professor of Exercise Science at the University of Iowa whose contributions included mentoring future investigators and seminal studies in the areas of thermoregulation during exercise, responses of the diencephalon to elevated temperatures, fluid absorption during heat stress, and the role of heat shock proteins in circulatory failure.

  14. Bioelectromagnetics, Carl Durney, and dosimetry: some historical remarks.

    PubMed

    Schwan, H P

    1999-01-01

    The contributions of Carl Durney to dosimetry have decisively advanced the bioelectromagnetics field and led to significant revisions of relevant health standards. Three items come to mind while studying his work: 1. The work of Carl Durney and his colleagues in dosimetry has advanced the bioelectromagnetics field most significantly whereas more abundant work of a biomedical nature has had less impact. More biophysics work is desirable. 2. The rationale for the specific absorption rate as a basis of health standards needs further elaboration. The need for scaling animal results is stressed. 3. Dosimetry at the cellular level (microdosimetry) is essential if one cares to discuss direct field interactions at the cellular and macromolecular level. Carl Durney's recognition of this need is stated. Carl Durney's wide range of productive interests is indicated by several tables. They summarize his many contributions to electrical engineering, education, bioelectromagnetic dosimetry, hyperthermia, NMR, and field-induced biophysical phenomena at the molecular and cellular level. His scientific work is summarized, including how his interest changed with time. His scientific accomplishment and productive interaction with students, colleagues, and society sets an example to be admired.

  15. Marketing Analysis for the Nontraditional Student at Carl Sandburg College.

    ERIC Educational Resources Information Center

    Sundberg, Lori

    With the wide range of students community colleges must provide services for, there is an increasing need for colleges to analyze and segment their marketing efforts. As part of an effort to focus on specific market segments and take into account internal and external environments, an analysis was conducted at Illinois' Carl Sandburg College (CSC)…

  16. Dr. Wernher Von Braun presents a certificate

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left), director of the Marshall Space Flight Center, presents a humorous certificate to Major General Charles W. Eifler, commanding general of Redstone Arsenal, at the close of a farewell luncheon for the general prior to General Eifler moving to a new European duty station.

  17. Carl Ludwig: the man, his time, his influence.

    PubMed

    Zimmer, H G

    1996-01-01

    Carl Ludwig (1816-1895) was the driving force in the foundation and development of scientifically based and experimentally oriented physiology against natural philosophy and vitalism that prevailed during the first quarter of the 19th century in Germany. He was the representative of a small group of young, highly talented and dynamic physiologists aiming at implementing the laws of physics and chemistry as the only active forces in physiologic processes. These "organic physicists" included Emil du Bois-Reymond (1818-1896), Ernst Brücke (1819-1892), and Hermann Helmholz (1821-1894). Carl Ludwig wrote the program of this group in the form of a textbook of physiology that was considered revolutionary, provocative and premature. His academic life, his inventions and discoveries, his scientific achievements, his influence and his personality are reviewed. Since every person can be viewed only in the context of his time, the political background, the economic and social situation, the conditions for science and research as well as the cultural climate that were characteristic for the decisive years of Carl Ludwig are described to some extent. It is shown that Carl Ludwig and his contemporary organic physicists lived and grew into a science- and research-oriented period which had been prepared and paved by men like Johannes Evangelista Purkinje (1787-1869), Ernst Heinrich Weber (1795-1878), Alfred Wilhelm Volkmann (1800-1877), Johannes Müller (1801-1858) and Gustav Theodor Fechner (1801-1887). They benefited from this enormous scientific development and contributed to it to a large and significant extent so that it ultimately turned out to be the most productive and influential period in the history of German physiology. Some of the numerous scholars who had studied with Carl Ludwig carried his approach to physiology into the 20th century: Adolf Fick (1829-1901), Otto Frank (1865-1944), Iwan Petrowitsch Pawlow (1849-1936) and Henry Pickering Browditch (1840-1911).

  18. Implementation of the Carl D. Perkins Vocational Education Act. Statement before the Committee on Education and Labor, United States House of Representatives. GAO Testimony.

    ERIC Educational Resources Information Center

    Gainer, William J.

    The Carl D. Perkins Vocational Education Act seeks to: (1) provide vocational education to underserved groups; and (2) encourage program improvement and modernization. Although the General Accounting Office (GAO) believes that Perkins Act funds are being used appropriately for the most part, a number of potential problems were identified regarding…

  19. USS Carl Vinson SDMS (Spatial Data Management System)

    DTIC Science & Technology

    1983-06-01

    Christopher F. Herot Jane Barnett Richard Carling Mark Friedell David Kramlich Ronni L. Rosenberg Computer Corporation of America Four Cambridge Center...or air- craft ). To return to the map display from an Ispace, the user twists the joystick counterclockwise. To exit the map display and return to the...Kramlich, and Ronni L. Rosenberg. L1 CALI Vinson SDMS Qpator’.SI MAnal. Computer Corporation of America (February1983). I. Schmolze, Jim, Mark Friedell

  20. Theodore von Karman

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Theodore von Karman. NACA: In the eyes of most aeronautical experts, the overall record of Max Munk in aerodynamic research falls short of that achieved by fellow immigrant Theodore von Karman (the short man in the double breasted coat in the middle), shown here visiting Langley in December 1926. People in the photo include Max Munk, aerodynamic researcher; Theodore von Karman; George Lewis, director of research; Henry Reid, engineer in charge; Fred Weick, PRT head; Paul Hemke; Elliott Reid, future Stanford University Professor.

  1. Living with von Willebrand Disease

    MedlinePlus

    ... from the NHLBI on Twitter. Living With von Willebrand Disease If you have von Willebrand disease (VWD), you ... that they get tested too. Pregnancy and von Willebrand Disease Pregnancy can be a challenge for women who ...

  2. Neuroscience of water molecules: a salute to professor Linus Carl Pauling.

    PubMed

    Nakada, Tsutomu

    2009-04-01

    More than 35 years ago double Nobel laureate Linus Carl Pauling published a powerful model of the molecular mechanism of general anesthesia, generally referred to as the hydrate-microcrystal (aqueous-phase) theory. This hypothesis, based on the molecular behavior of water molecules, did not receive serious attention during Pauling's life time, when scientific tools for examining complex systems such as the brain were still in their infancy. The situation has since drastically changed, and, now, in the twenty first century, many scientific tools are available for examining different types of complex systems. The discovery of aquaporin-4, a subtype of water channel abundantly expressed in glial systems, further highlighted the concept that the dynamics of water molecules in the cerebral cortex play an important role in important physiological brain functions including consciousness and information processing.

  3. The ZOG Technology Demonstration Project: A System Evaluation of USS CARL VINSON (CVN 70)

    DTIC Science & Technology

    1984-12-01

    rNPRDC TR 85-14 DECEMBER 1984 ~JI 00o THE ZOG TECHNOLOGY DEMONSTRATION PROJECT : 00 A SYSTEM EVALUATION OF USS CARL VINSON ICVN 70) Lfl Reproduced...California 92152 NPR.DC TR 85-14 December 1984 THE ZOG TECHNOLOGY DEMONSTRATION PROJECT : A SYSTEM EVALUATION ON USS CARL VINSON (CVN 70) Nicholas H...ZOG TECHNOLOGY DEMONSTRATION PROJECT : A SYSTEM EVALUATION ON THE USS CARL VINSON (CVN 70) Van Matre, Nicholas; Moy, Melvyn, C.; McCann, Patrick, H

  4. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (left) and Fred W. Kelley examine a ST-100 Stellar Instrument Platform in the astrionics lab. Dr. Von Braun, then deputy associate administrator for planning, NASA, was visiting on the anniversary of the establishment of the Marshall Space Flight Center.

  5. Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

  6. Dr. von Braun and Army Ballistics Missile Agency (ABMA) Group

    NASA Technical Reports Server (NTRS)

    1959-01-01

    This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

  7. Wernher von Braun with German Officers and Others

    NASA Technical Reports Server (NTRS)

    1942-01-01

    General Erich Fellgiebel, head of the German Army Information Service during World War II, congratulates members of the von Braun rocket team from Peenemunde for their October 3, 1942 A4 flight. Pictured front center is General Erich Fellgiebel. Shaking hands are General Walter Dornberger (left) and General Janssen, commanding officer of Peenemuende with Rudolph Hermarn to their right. Picture left to right in the back row are Wernher von Braun, Captain Stoelzel, Luftwaffe, and Dr. Gerhard Reisig.

  8. Group Theoretical Interpretation of von Neumann's Theorem on Composite Systems.

    ERIC Educational Resources Information Center

    Bergia, S.; And Others

    1979-01-01

    Shows that von Neumann's mathematical theorem on composite systems acquires a transparent physical meaning with reference to a suitable physical example; a composite system in a state of definite angular momentum. Gives an outline of the theorem, and the results are restated in Dirac's notation, thus generalizing von Neumann's results which were…

  9. Modeling time-varying growth using a generalized von Bertalanffy model with application to bloater (Coregonus hoyi) growth dynamics in Lake Michigan

    USGS Publications Warehouse

    Szalai, Emily B.; Fleischer, Guy W.; Bence, James R.

    2003-01-01

    A concurrent increase in lakewide abundance and decrease in size-at-age of bloater (Coregonus hoyi) in Lake Michigan have suggested density-dependent growth regulation. We investigated these temporal patterns by fitting a dynamic von Bertalanffy model and length–weight relationship with time-varying parameters to mean length- and weight-at-ages (ages 1–7) from annual surveys (1965-–1999). We modeled yearling length, asymptotic size (L‰), and the parameters of a power relationship between mean weight and mean length (α and β) as changing slowly over time using a random walk model. The Brody growth coefficient (k) was modeled as a linear function of L‰ with year-specific random deviations. Our results support a positive relationship between L‰ and k, indicating that under conditions supporting larger asymptotic lengths, individuals approach the asymptote more rapidly. We explored the relationship between year-specific growth parameters and indices of lakewide bloater abundance and found evidence of density-dependent growth. However, in the most recent years, L‰ and yearling length have remained low in Lake Michigan despite low bloater abundances, suggesting the occurrence of a fundamental shift in the food web.

  10. Carl Schmidt -- a chemical tourist in Victorian Britain.

    PubMed

    Ross, R Stefan

    2005-03-01

    Carl Schmidt is one of the founders of modern biochemistry. He wrote numerous scientific publications, and left future generations several important documents that included two extensive hand-written travel reports from 1857 and 1864. In these, Schmidt paints a lively and impressive picture of industry in Victorian Britain from a personal perspective, showing this key period of European economic history in a unique light. Thus, it is rewarding to follow Schmidt on his travels through Britain, which he regarded as the workshop of the world and a shining but unattainable example for the industrial development of his home country.

  11. Conversations: with Carl Pilcher [interview by Johan Benson].

    PubMed

    Pilcher, C

    1998-11-01

    An interview with Carl Pilcher, science program director for solar system exploration at NASA, examines NASA's past, present, and planned missions to explore the solar system. Specific questions relate to the status of current and planned missions, science results of the Pathfinder mission to Mars, cooperation with the Japanese space agency, the status of the search for extraterrestrial life in solar system meteoroids and asteroids, mission size for more in-depth exploration, reports of water on the moon, and the exploration of near-Earth objects.

  12. The anthropology of Carl Jung: Implications for pastoral care.

    PubMed

    Hunt-Meeks, S

    1983-09-01

    This article examines the basic tenets of Carl Jung's anthropology, including intrapsychic structure, relationships, society, and the process of individuation. It then turns to his ideas about God and religion. Jung builds his understanding of God from his work in psychology, and because of that method, there are several major problems with his theologizing. Nevertheless, his insights are extremely valuable to the field of pastoral care, and ministers would do very well to appreciate his contribution, though always with a critical eye to its limitation.

  13. The professionalization of Carl G. Jung's analytical psychology clubs.

    PubMed

    Samuels, A

    1994-04-01

    This paper addresses (1) the history of a cluster of unusual institutions-analytical psychology clubs--which started in 1916 and by 1934 had become established in many of the countries in the world in which there was interest in the analytical psychology of Carl G. Jung; (2) the conflicts involved in trying to unite the relatively informal earlier "Jung Clubs" with the more formal societies being established by the increasing numbers of professionally trained analysts; and (3) the wider cultural and social issues included in the professionalization of analytical psychology.

  14. Science fiction and the history of the astro-department of Carl Zeiss Jena (German Title: Science Fiction und die Geschichte der Astroabteilung von Carl Zeiss Jena)

    NASA Astrophysics Data System (ADS)

    Beck, Hans G.

    This contribution uses the literary form of science fiction in retrospect, in order to display the initial conditions given in the run-up of the founding of the astro-department of the Zeiss factory. Written minutes (supposedly found during restoration works in the people's house in Jena) introduce the participants of a sort of founding party of the main actors Ernst Abbe, Otto Schott, Siegfried Czapski, Hans Harting, Albert König, Franz Meyer and Walter Villiger. Their contributions to the discussion yield a market analysis, based on the past development of the technology of astronomical instruments, the international competitors' state of the art, and the assessment of the future development in astronomy and especially of astrophysics. The contribution presents a piece of modern history of the year 1987; it was presented as a talk on May 13 of the same year, when Rolf Riekher celebrated his 65th birthday.

  15. von Willebrand Disease.

    PubMed

    Swami, Arjun; Kaur, Varinder

    2016-01-01

    von Willebrand disease (vWD) is the most common inherited disorder of hemostasis and comprises a spectrum of heterogeneous subtypes. Significant advances have been made in understanding von Willebrand factor ( vWF) gene mutations, resultant physiologic deficits in the vWF peptide, and their correlation to clinical presentation. Diagnostic tests for this disorder are complex, and interpretation requires a thorough understanding of the underlying pathophysiology by the practicing physician. The objective of this review is to summarize our current understanding of pathophysiology, laboratory investigations, and evolving treatment paradigm of vWD with the availability of recombinant von Willebrand factor.

  16. Tutorial Facilitation in the Humanities Based on the Tenets of Carl Rogers

    ERIC Educational Resources Information Center

    Heim, Caroline

    2012-01-01

    This article introduces a model for group facilitation in the humanities based on Carl Rogers' model for group psychotherapy. Certain aspects of Carl Rogers' reflective learning strategies are reappraised and principles, specific only to psychotherapy, are introduced. Five of Rogers' axioms are applied to the tutorial discussion model: a…

  17. 78 FR 39715 - Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical Education Improvement Act of 2006 (P.L. 109-270) State Plan Guide AGENCY: Office of Vocational and Adult Education (OVAE... of Collection: Carl D. Perkins Career and Technical Education Improvement Act of 2006 (P.L....

  18. Richard von Volkmann

    PubMed Central

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R.

    2008-01-01

    Richard von Volkmann (1830–1889), one of the most important surgeons of the 19th century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867–1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the “antiseptic technique” to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann’s contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children’s fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics. PMID:18196438

  19. Von Willebrand disease

    MedlinePlus

    ... done to diagnose this disease include: Bleeding time Blood typing Factor VIII level Platelet function analysis Platelet count Ristocetin cofactor test Von Willebrand factor specific tests ... invasive procedure. Blood plasma or certain factor VIII preparations may also ...

  20. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the astronautics lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics lab.

  1. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), Deputy Associate Administrator for Planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the Astronautics Lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics Lab.

  2. Carl Rogers and the larger context of therapeutic thought.

    PubMed

    Wachtel, Paul L

    2007-09-01

    Carl Rogers' classic account (see record 2007-14639-002) of the necessary and sufficient conditions for therapeutic personality change is examined in light of developments in theory and practice since the time he wrote. Rogers' ideas, which diverged from and were very largely a challenge to, the dominant psychoanalytic ideology of the era in which he wrote, are considered in relation to new theoretical developments in what has come to be called relational psychoanalysis. They are also considered in light of the greatly increased influence of and substantial evidence supporting behavioral and cognitive-behavioral approaches. Points of convergence and divergence among these approaches are examined. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  3. 'On periodical depressions and their pathogenesis' by Carl Lange (1886).

    PubMed

    Schioldann, Johann

    2011-03-01

    Carl Lange was the founding father of neurology in Denmark, authoring several pioneering works within this field; however, these remained largely unknown internationally as he did not have them translated into a major language. He became a pioneer of psychophysiology with his contribution to the so-called James-Lange theory of emotion. His treatise on'periodical depressions' ('the Lange theory of depressions', 1886), is not only an early historical landmark but also a masterly 'modern' description concerning the nosology and nosography of recurrent depressions. Moreover, it is a landmark in the early history of lithium therapy, sadly ignored by Lange's contemporaries, but which little more than half a century later, with Cade's rediscovery of lithium's therapeutic effect in mood disorders in 1949, ushered in modern psychopharmacology.

  4. "Decknamen or pseudochemical language"? Eirenaeus Philalethes and Carl Jung.

    PubMed

    Newman, W R

    1996-01-01

    It is impossible to investigate the historiography of alchemy without encountering the ideas of the "father of analytical psychology", Carl Jung. Jung argued that alchemy, viewed as a diachronic, trans-cultural entity, was concerned more with psychological states occurring in the mind of the practitioner than with real chemical processes. In the course of elucidating this idea, Jung draws on a number of alchemical authors from the early modern period. One of these is Eirenaeus Philalethes, the pen name of George Starkey (1628-1665), a native of Bermuda who was educated at Harvard College, and who later immigrated to London. A careful analysis of Starkey's work shows, however, that Jung was entirely wrong in his assessment of this important representative of seventeenth-century alchemy. This finding casts serious doubt on the Jungian interpretation of alchemy as a whole.

  5. Re-discovering Mendel: The Case of Carl Correns

    NASA Astrophysics Data System (ADS)

    Rheinberger, Hans-Jörg

    2015-01-01

    Carl Erich Correns (1864-1933) is remembered in the annals of science as one of the three botanists who re-discovered Mendel's laws. He can also, however, be regarded as one of the founding figures of classical genetics in Germany. Between 1894 and 1899 he carried out the crossing experiments with corn and peas that led to the re-statement of Gregor Mendel's (1822-1884) results. Between 1900 and 1910, he explored the complications of these laws, including the coupling of factors due to their chromosomal location and the inheritance of sex, in a great number of plant species. In later years Correns became interested in and experimented on phenomena of extra-nuclear inheritance.

  6. Carl Gustav Jung and Granville Stanley Hall on Religious Experience.

    PubMed

    Kim, Chae Young

    2016-08-01

    Granville Stanley Hall (1844-1924) with William James (1842-1910) is the key founder of psychology of religion movement and the first American experimental or genetic psychologist, and Carl Gustav Jung (1875-1961) is the founder of the analytical psychology concerned sympathetically about the religious dimension rooted in the human subject. Their fundamental works are mutually connected. Among other things, both Hall and Jung were deeply interested in how the study of religious experience is indispensable for the depth understanding of human subject. Nevertheless, except for the slight indication, this common interest between them has not yet been examined in academic research paper. So this paper aims to articulate preliminary evidence of affinities focusing on the locus and its function of the inner deep psychic dimension as the religious in the work of Hall and Jung.

  7. Existential perspective in the thought of Carl Jung.

    PubMed

    Shelburne, W A

    1983-03-01

    It is argued that there is a significant existential perspective in the thought of Carl Jung. Similarities and differences with some of the views of Jean Paul Sartre are explored as a way of developing this perspective and to show how a philosophy of a man might be developed drawing from both sources. Jung is shown to be in disagreement with Sartre in defending an idea of a determinate human nature, describing the self in a developmental way, and in not claiming that human freedom is absolute or unconditioned. Nevertheless, the Jungian concept of individuation is similar to Sartre's ideal of authenticity, in that both focus on the goal of achieving meaningful existence through development of inner resources, creative exercise of freedom, and overcoming self-deception.

  8. On the history of Ludwig von Bertalanffy’s “General Systemology”, and on its relationship to cybernetics – part III: convergences and divergences

    PubMed Central

    Drack, Manfred; Pouvreau, David

    2015-01-01

    Bertalanffy’s so-called “general system theory” (GST) and cybernetics were and are often confused: this calls for clarification. In this article, Bertalanffy’s conceptions and ideas are compared with those developed in cybernetics in order to investigate the differences and convergences. Bertalanffy was concerned with first order cybernetics. Nonetheless, his perspectivist epistemology is also relevant with regard to developments in second order cybernetics, and the latter is therefore also considered to some extent. W. Ross Ashby’s important role as mediator between GST and cybernetics is analysed. The respective basic epistemological approaches, scientific approaches and inherent world views are discussed. We underline the complementarity of cybernetic and “organismic” trends in systems research within the unitary hermeneutical framework of “general systemology”. PMID:26612966

  9. von Willebrand factor and von Willebrand disease.

    PubMed

    Matsui, Taei; Hamako, Jiharu

    von Willebrand factor (VWF) has two major roles in hemostasis, as a form of molecular glue which functions in platelet plug formation and as a protective transporter for coagulation factor VIII (FVIII). VWF shows a multimeric chain structure composed of 270 kDa subunits containing binding domains for FVIII, platelet and collagens. Biosynthesis, storage, secretion of VWF and the cleavage process by ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type 1 repeats 13) regulating VWF activity have been elucidated. von Willebrand disease (VWD) is an autosomal bleeding disorder, first documented in 1926, caused by quantitative or qualitative deficiency of VWF. The classification and molecular pathogenesis of VWD have been developed during a 90-year period based on clinical laboratory analysis of VWF, and structure-function analysis of mutant VWF with amino acid substitutions (genetic changes). VWF is a unique and very large multifunctional plasma protein, the hemostatic activity of which is dynamically regulated by physiological shear stress in the blood stream.

  10. Astronaut Carl Walz shows off stowage locker for GPS on-orbit operations

    NASA Technical Reports Server (NTRS)

    1993-01-01

    On Discovery's middeck Astronaut Carl E. Walz shows off stowage locker for gear supporting the Global Positioning System (GPS) on-orbit operations. To the left is a sign which reads 'Ace HST Tool Testers'.

  11. Energetische Verwertung von Biomasse

    NASA Astrophysics Data System (ADS)

    Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    Etwa 0,1% der Solarenergie wandeln sich durch Photosynthese aus dem Kohlendioxid der Luft in Biomasse um. Die Biomassen sind als Festbrennstoff nutzbar oder zu gasförmigen Brennstoffen weiterverarbeitbar. Zwei Arten von Biomassen sind zu unterscheiden: Anfallende Biomasse

  12. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

  13. Mendelian inheritance in Germany between 1900 and 1910. The case of Carl Correns (1864-1933).

    PubMed

    Rheinberger, H J

    2000-12-01

    Carl Correns (1864-1933) came to recognize Mendel's rules between 1894 and 1900 while trying to find out the mechanism of xenia, that is, the direct influence of the fertilizing pollen on the mother plant in maize and peas among other species. In this paper, I am concerned with the ten years of Correns' work after the annus mirabilis of 1900 until 1910, when the main outlines of the new science of genetics had been established. It is generally assumed that after 1900 Correns quickly began probing the limits of Mendelian inheritance, both as far as the explanatory force of formal transmission genetics and the generality of Mendel's laws are concerned. A careful examination of his papers however shows that he was much more interested in the scope of Mendelian inheritance than in its limits. Even his work with variegated Mirabilis plants, which historiographical folklore still presents as a result of Correns' growing interest in cytoplasmic inheritance, can be shown to have been conducted to corroborate just the opposite, namely, the validity of the nuclear paradigm. The paper will show that Correns' research results in those years (among them the Mendelian inheritance of sex in higher plants) were the outcome of a complex experimental program which involved breeding experiments with dozens of different species.

  14. The Roosevelt years: crucial milieu for Carl Rogers' innovation.

    PubMed

    Barrett-Lennard, Godfrey T

    2012-02-01

    This study explores broad features of political culture and event of the 1930s and World War 2 years, viewed in relation to the emergence and rapid early growth of the new therapy of Carl Rogers. The paper traces Rogers' early professional life and examines distinctive emphases in sociopolitical thought and development during Franklin D. Roosevelt's leadership as President over the prolonged emergency of the Great Depression and the crisis of the War. The study includes a focus on the President's own outlook and style, pertinent New Deal innovations, and wartime needs. Twelve features of this larger context are discriminated as together having vital importance for the new therapy and its founder. The congruent courses of the macrocontext and of Rogers' innovation are followed to the ending of Roosevelt's life. Direct causation is not attributed, but the evidence adduced newly points to particular contours of a larger environment favorable for the expression of Rogers' values and rare ability. In sum, the author concludes that a synergy of highly conducive historical circumstance and individual exceptionality contributed to the philosophical underpinnings, attitudinal values and early momentum of Rogers' client-centered therapy.

  15. Carl Woese, Dick Young, and the roots of astrobiology

    PubMed Central

    Rummel, John D

    2014-01-01

    The beginning of the space age in the late 1950s gave rise to innovative and interdisciplinary research concepts and perspectives, including the concept of “exobiology” as a way to approach the fundamental aspects of biology through a study of life outside of the Earth, if it existed. This concept was embodied by NASA into its formal Exobiology Program and into the philosophy of the program both before and after the Viking missions that were launched to Mars to search for signs of life in 1975. Due to both management flexibility and an acceptance of the interdisciplinary nature of the problem of “life in the universe,” NASA program managers, and particularly Richard S Young who ran the Exobiology Program beginning 1967, have made some excellent investments in paradigm altering science of great use both on Earth and on future space missions. The work of Carl Woese is one such example, which has revolutionized our understanding of the microbial world and the relationships of all life on Earth. PMID:24572623

  16. Carl Woese, Dick Young, and the roots of astrobiology.

    PubMed

    Rummel, John D

    2014-01-01

    The beginning of the space age in the late 1950s gave rise to innovative and interdisciplinary research concepts and perspectives, including the concept of "exobiology" as a way to approach the fundamental aspects of biology through a study of life outside of the Earth, if it existed. This concept was embodied by NASA into its formal Exobiology Program and into the philosophy of the program both before and after the Viking missions that were launched to Mars to search for signs of life in 1975. Due to both management flexibility and an acceptance of the interdisciplinary nature of the problem of "life in the universe," NASA program managers, and particularly Richard S Young who ran the Exobiology Program beginning 1967, have made some excellent investments in paradigm altering science of great use both on Earth and on future space missions. The work of Carl Woese is one such example, which has revolutionized our understanding of the microbial world and the relationships of all life on Earth.

  17. The Carl Sagan solar and stellar observatories as remote observatories

    NASA Astrophysics Data System (ADS)

    Saucedo-Morales, J.; Loera-Gonzalez, P.

    In this work we summarize recent efforts made by the University of Sonora, with the goal of expanding the capability for remote operation of the Carl Sagan Solar and Stellar Observatories, as well as the first steps that have been taken in order to achieve autonomous robotic operation in the near future. The solar observatory was established in 2007 on the university campus by our late colleague A. Sánchez-Ibarra. It consists of four solar telescopes mounted on a single equatorial mount. On the other hand, the stellar observatory, which saw the first light on 16 February 2010, is located 21 km away from Hermosillo, Sonora at the site of the School of Agriculture of the University of Sonora. Both observatories can now be remotely controlled, and to some extent are able to operate autonomously. In this paper we discuss how this has been accomplished in terms of the use of software as well as the instruments under control. We also briefly discuss the main scientific and educational objectives, the future plans to improve the control software and to construct an autonomous observatory on a mountain site, as well as the opportunities for collaborations.

  18. Carl Sagan and Joseph Shklovsky: Intelligent Life in the Universe

    NASA Astrophysics Data System (ADS)

    Kurt, Vladimir

    J. S. Shklovsky and Carl Sagan played an outstanding role in modern astronomy. Their names are well known not only to professional astronomers, but also to millions of educated people in many countries, which are interested in modern state of science research. Among these trends of modern science, which are difficult to define, are such problems, as the creation of Solar system, the origin of life on Earth, the evolution of living organisms on Earth from the simplest viruses to Homo Sapiens, the evolution of intelligence and technology. Finally, both outstanding scientists were deeply interested in the problem of SETI (Search Extraterrestrial Intelligence), i.e. search of extraterrestrial civilizations and methods of making contacts with them. And both scientists were high professionals in their fields. Joseph Shklovsky was a theoretical astronomer in all fields of modern astronomy (geophysics and physics of the upper atmosphere of the Earth, Sun and Solar Corona, Interplanetary Medium and Solar Wind, Interstellar Medium, Supernova and their remnants, the Galaxy and galaxies, Quasars and Cosmology). There is hardly a field in modern astrophysics (except perhaps the theory of the interior structure of stars), where Joseph Shklovsky has not l a bright stamp of his talent…

  19. Current Status of Carl Sagan Observatory in Mexico

    NASA Astrophysics Data System (ADS)

    Sanchez-Ibarra, A.

    The current status of Observatory "Carl Sagan" (OCS) of University of Sonora is presented. This project was born in 1996 focused to build a small solar-stellar observatory completely operated by remote control. The observatory will be at "Cerro Azul", a 2480 m peak in one of the best regions in the world for astronomical observation, at the Sonora-Arizona desert. The OCS, with three 16 cm solar telescopes and a 55 cm stellar telescope is one of the cheapest observatories, valuated in US200,000 Added to its scientific goals to study solar coronal holes and Supernovae Type 1A, the OCS has a strong educative and cultural program in Astronomy to all levels. At the end of 2001, we started the Program "Constelacion", to build small planetariums through all the countries with a cost of only US80,000. Also, the webcast system for transmission of the solar observations from the prototype OCS at the campus, was expanded to webcast educational programs in Astronomy since July of this year, including courses and diplomats for Latin American people. All of these advances are exposed here.

  20. Carl von Clausewitz’s Concept of Military Genius and the Cognitive Illusions that Preclude Clear Thinking

    DTIC Science & Technology

    2013-03-25

    hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and...completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of...University/Command and Staff (703) 784-3330 (Admin Office) _ United States Marine Corps Command and Staff College Marine Corps University 2076

  1. Management of the von Roos operator

    NASA Astrophysics Data System (ADS)

    Molinar-Tabares, Martin; Castro-Arce, Lamberto; Figueroa-Navarro, Carlos; Campos-Garcia, Julio

    When an electron is inside a semiconductor medium its effective mass rises from the shielding of the crystalline structure. When we have a semiconductor with a constant concentration the effective mass has a fixed value, and in this case, it can be easy to solve the Schrodinger equation of the particle, but if the concentration varies spatially, the effective mass will no longer constant and the solution can be difficult to find. The general form of the kinetic energy operator for a particle with variable mass is proposed for von Roos, this operator is characterized by some parameters whose values are subjected to a restriction. From a numerical solution of the Schrodinger equation we analyze the energies of an electron with position-dependent effective mass working with some values of the parameter of the von Roos operator. We acknowledge the support of SNI CONACYT.

  2. [Tone psychology and music research as catalysts of experimental-scientific practice and methodology in the circle of Carl Stumpf].

    PubMed

    Klotz, Sebastian

    2008-09-01

    The study of acoustics, harmonics and of music has been providing scientific models since Greek Antiquity. Since the early modern ages, two separate cultures began to emerge out of the study of music: a technical acoustics and an aesthetically and philosophically inspired musical criticism. In the writings of Johann Friedrich Herbart (1811) a scientific approach to musical aesthetics and to music perception is taking shape that reinstalls the listening process as a highly complex and logical phenomenon. By opening music for a scientific psychological investigation, Herbart pioneered the physiologically and acoustically grounded seminal work by Hermann von Helmholtz On the sensations of tone (1863) which the author considered a prerequisite for musical aesthetics and music theory. Helmholtz in turn inspired the philosopher and psychologist Carl Stumpf to further investigate musical perception (beginning in 1883). To Stumpf, it provided a paradigm for experimental psychology as mental functions and phenomena could be studied in detail. These functions and phenomena are the actual objects of scientific study in Stumpf's inductive and descriptive psychology. Combining insights from statistics, ethnology, anthropology, psychoacoustics and the cultural history of mankind, Stumpf and his team developed a new blend of science which absorbs styles of reasoning, analytical procedures and academic convictions from natural history, the natural sciences and the humanities but at the same time identifies shortcomings of these approaches that fail to grasp the complexities of psychic functions. Despite their reliance on the quasi-objective phonograph and despite their commitment to objectivity, precision and measurement, mental phenomena relating to tonal perception and to music provided too complex a challenge to be easily articulated and shared by the scientific community after 1900. The essay illustrates these tensions against the background of a history of objectivity.

  3. Von Karman swirling flows

    NASA Astrophysics Data System (ADS)

    Zandbergen, P. J.; Dijkstra, D.

    A development history is presented for research on the problem of swirling flow infinite disks from its formulation by von Karman in 1921 through the treatments of Batchelor (1951) and Stewartson (1953) to the present, with a view to both its one-disk and two-disk forms. Attention is given to the stability of the stationary solutions for these problems, and to the case where the radii of the disks are finite. The question as to the extent to which the Karman swirling flow occurs in a finite radial geometry is noted to be of fundamental importance.

  4. Dr. Wernher Von Braun

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

  5. von Willebrand Disease (For Parents)

    MedlinePlus

    ... problems because the levels or functioning of these blood components needed for clotting are abnormal. continue Types of von Willebrand Disease As with many conditions, there are various forms ... of von Willebrand factor in the blood is reduced; the level of factor VIII also ...

  6. Four-Year Plan under the Carl D. Perkins Vocational and Technical Education Act of 1998, 2000-2004.

    ERIC Educational Resources Information Center

    Wisconsin Technical Coll. System Board, Madison.

    This is a plan for the last four years of the Wisconsin Technical College System Board's five-year plan period covered by the latest amendments to the Carl D. Perkins Vocational and Technical Education Act. The Carl D. Perkins Act of 1998 is a federally funded program designed to assist states in developing their academic, vocational, and…

  7. Carl Koller, cocaine, and local anesthesia: some less known and forgotten facts.

    PubMed

    Goerig, Michael; Bacon, Douglas; van Zundert, André

    2012-01-01

    Modern-day local anesthesia began in 1884 with a discovery by a young unknown ophthalmologist from Vienna named Carl Koller, who placed a cocaine solution on the cornea, thus producing insensibility. The news of his discovery spread throughout the world in less than a month. "Not surprisingly," a controversial priority discussion emerged. There is little information about this "dark side" of Koller's discovery and only sparse data about the personalities involved in this controversy. In addition, Carl Koller's decision to leave Vienna is also surrounded in secrecy. The story surrounding the revelation of the local anesthetic effect of cocaine and the personalities involved is fascinating and relatively unknown.

  8. Psyche=singularity: A comparison of Carl Jung's transpersonal psychology and Leonard Susskind's holographic string theory

    NASA Astrophysics Data System (ADS)

    Desmond, Timothy

    In this dissertation I discern what Carl Jung calls the mandala image of the ultimate archetype of unity underlying and structuring cosmos and psyche by pointing out parallels between his transpersonal psychology and Stanford physicist Leonard Susskind's string theory. Despite his atheistic, materialistically reductionist interpretation of it, I demonstrate how Susskind's string theory of holographic information conservation at the event horizons of black holes, and the cosmic horizon of the universe, corroborates the following four topics about which Jung wrote: (1) his near-death experience of the cosmic horizon after a heart attack in 1944; ( 2) his equation relating psychic energy to mass, "Psyche=highest intensity in the smallest space" (1997, 162), which I translate into the equation, Psyche=Singularity; (3) his theory that the mandala, a circle or sphere with a central point, is the symbolic image of the ultimate archetype of unity through the union of opposites, which structures both cosmos and psyche, and which rises spontaneously from the collective unconscious to compensate a conscious mind torn by irreconcilable demands (1989, 334-335, 396-397); and (4) his theory of synchronicity. I argue that Susskind's inside-out black hole model of our Big Bang universe forms a geometrically perfect mandala: a central Singularity encompassed by a two-dimensional sphere which serves as a universal memory bank. Moreover, in precise fulfillment of Jung's theory, Susskind used that mandala to reconcile the notoriously incommensurable paradigms of general relativity and quantum mechanics, providing in the process a mathematically plausible explanation for Jung's near-death experience of his past, present, and future life simultaneously at the cosmic horizon. Finally, Susskind's theory also provides a plausible cosmological model to explain Jung's theory of synchronicity--meaningful coincidences may be tied together by strings at the cosmic horizon, from which they

  9. John von Neumann Birthday Centennial

    SciTech Connect

    Grcar, Joseph F.

    2004-11-12

    In celebration of John von Neumann's 100th birthday, a series of four lectures were presented on the evening of February 10, 2003 during the SIAM Conference on Computational Science and Engineering in San Diego. The venue was appropriate because von Neumann spent much of the later part of his life, in the 1950's, as an unofficial ambassador for computational science. He was then the only senior American scientist who had experience with the new computers (digital, electronic, and programmable) and a vision of their future importance. No doubt he would have relished the chance to attend a meeting such as this. The first speaker, William Aspray, described the ''interesting times'' during which computers were invented. His remarks were based on his history [1] of this period in von Neumann's life. We were honored to have John von Neumann's daughter, Marina von Neumann-Whitman, as our second speaker. Other accounts of von Neumann's life can be found in books by two of his colleagues [2] and [3]. Our third speaker, Peter Lax, provided both mathematical and international perspectives on John von Neumann's career. Finally, Pete Stewart spoke about von Neumann's numerical error analysis [4] in the context of later work; this talk did not lend itself to transcription, but readers may consult the historical notes in [5]. Our thanks to all the speakers for a remarkable evening. We are grateful to the DOE Applied Mathematical Sciences (AMS) program for partially supporting these lectures. Thanks are also due to SIAM and William Kolata, to our emcee, Gene Golub, to Paul Saylor for recording and editing, and to Barbara Lytle for the transcriptions. More about von Neumann's work can be learned from the recent American Mathematical Society proceedings [6].

  10. von Karman Vortices

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Each of these swirling clouds is the result of a meteorological phenomenon known as a von Karman vortex. These vortices appeared over Alexander Selkirk Island in the southern Pacific Ocean. Rising precipitously from the surrounding waters, the island's highest point is nearly a mile (1.6 km) above sea level. As wind-driven clouds encounter this obstacle, they flow around it to form large, spinning eddies. This image was acquired by Landsat 7's Enhanced Thematic Mapper plus (ETM+) sensor on September 15, 1999. This is a false-color composite image made using shortwave infrared, infrared, and near-infrared wavelengths. Image provided by the USGS EROS Data Center Satellite Systems Branch.

  11. Displaced Homemaker's Guide to the Carl Perkins Vocational Education Act of 1984.

    ERIC Educational Resources Information Center

    Displaced Homemakers Network, Washington, DC.

    This guide is intended to familiarize displaced homemakers with the provisions of the Carl D. Perkins Vocational Education Act of 1984. The first part of the guide details the act's funding for the following areas: sex equity coordinator, single parents and homemakers, sex bias and stereotyping, adult training and retraining, employment…

  12. A View of the Symbolic-Experiential Family Therapy of Carl Whitaker through Movie Analysis

    ERIC Educational Resources Information Center

    Cag, Pinar; Voltan Acar, Nilufer

    2015-01-01

    The movie "Ya Sonra" is evaluated in respect to the basic concepts and principles of symbolic-experiential family therapy. Carl Whitaker, who called his approach "Psychotherapy of Absurdity" mainly emphasized the concepts of absurdity, experientiality, and symbolism. Based on the hypothesis that film analysis supports and…

  13. Carl Gawboy, Ojibwe Regional Painter. With Teacher's Guide. Native Americans of the Twentieth Century.

    ERIC Educational Resources Information Center

    Minneapolis Public Schools, MN.

    A biography for the elementary grades of Carl Gawboy (Ojibwe), an American Indian painter, includes photographs of the artist and some of his work. A teacher's guide following the bibilography contains information on watercolor painting and the Ojibwe people, learning objectives and study questions, instructions for doing a watercolor painting and…

  14. Carl D. Perkins Vocational and Applied Technology Education Act as Amended.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC.

    This document contains the text of the Carl D. Perkins Vocational and Applied Technology Education Act, as amended. Title I, Vocational Education Assistance to the States, has two parts: Allotment and Allocation, and STate Organizational and Planning Responsibilities. Title II, Basic State Grants for Vocational Education, contains three parts:…

  15. Carl Rogers's Life and Work: An Assessment on the 100Th Anniversary of His Birth

    ERIC Educational Resources Information Center

    Kirschenbaum, Howard

    2004-01-01

    This article summarizes the life and work of America's most influential counselor and psychotherapist, Carl Rogers. He developed the client-centered, person-centered approach; popularized the term client; pioneered the recording of counseling cases; conducted landmark research on counseling and psychotherapy; and was a leader in the humanistic…

  16. The Application of Carl Rogers' Person-Centered Learning Theory to Web-Based Instruction.

    ERIC Educational Resources Information Center

    Miller, Christopher T.

    This paper provides a review of literature that relates research on Carl Rogers' person-centered learning theory to Web-based learning. Based on the review of the literature, a set of criteria is described that can be used to determine how closely a Web-based course matches the different components of Rogers' person-centered learning theory. Using…

  17. An Analysis of How Carl Rogers Enacted Client-Centered Conversation with Gloria.

    ERIC Educational Resources Information Center

    Wickman, Scott A.; Campbell, Cynthia

    2003-01-01

    This study analyzed Carl Rogers's session with Gloria in "Three Approaches to Psychotherapy" to determine how Rogers's conversational style functioned to enact his core conditions of empathy, genuineness, and unconditional positive regard. Rogers's conversational style was found to be congruent with his espoused theory as well as a…

  18. Education for the 1980s and Beyond: An Interview with Carl Rogers.

    ERIC Educational Resources Information Center

    Robinson, Edward H., III

    1985-01-01

    Presents an interview with Carl Rogers regarding education today and what it could be in the future. Discusses topics including politics and power, free choice versus conservatism, censorship, facilitators of learning, knowledge children need in today's world, and the changing society as it relates to humanistic education. (BH)

  19. The Coconstruction of Congruency: Investigating the Conceptual Metaphors of Carl Rogers and Gloria.

    ERIC Educational Resources Information Center

    Wickman, Scott A.; Campbell, Cynthia

    2003-01-01

    The counseling session between Carl Rogers and Gloria is one of the most widely used teaching tools in the field of counselor education. This article explores a framework for investigating conceptual metaphor, which provided a useful method for understanding how meaning negotiation took place within the session as well as how Rogers and Gloria…

  20. Dismissal of a Sociologist: The AAUP Report on Carl C. Taylor.

    ERIC Educational Resources Information Center

    Larson, Olaf F.; Williams, Robin M., Jr.; Wimberley, Ronald C.

    1999-01-01

    Examines the dismissal in 1931 of distinguished sociologist Carl C. Taylor after 11 years as an influential faculty member and dean at the State College of Agriculture and Engineering of North Carolina. Reviews the subsequent investigation by the American Association of University Professors. Highlights Taylor's career and contributions at…

  1. Consortia Formation and Characteristics under the "Carl D. Perkins Career and Technical Education Act of 2006"

    ERIC Educational Resources Information Center

    Staklis, Sandra; Klein, Steve

    2014-01-01

    The "Carl D. Perkins Career and Technical Education Act of 2006" ("Perkins IV") sets a minimum allocation requirement that secondary and postsecondary career and technical education (CTE) subgrantees must achieve to receive federal financing. An eligible recipient with an allocation below the funding threshold may obtain a…

  2. CARL Corporation to Market Knight Ridder DIALOG Databases to the Academic and Public Library Market.

    ERIC Educational Resources Information Center

    Machovec, George S.

    1996-01-01

    With the advent of CD-ROMs, libraries began to limit online searching via DIALOG. To increase DIALOG's market share, Colorado Alliance of Research Libraries (CARL) Corporation is developing graphical user interfaces using World Wide Web and Windows technology and has reached agreements with Knight Ridder Information and with most of their database…

  3. 78 FR 24394 - Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... Career and Technical Education Improvement Act of 2006 (P.L. 109-270) State Plan Guide. OMB Control... Agency Information Collection Activities; Comment Request; Carl D. Perkins Career and Technical Education Improvement Act of 2006 (P.L. 109-270) State Plan Guide AGENCY: Office of Vocational and Adult Education...

  4. Freedom through Language: Applications of the Ideas of Carl Rogers to the Teaching of Composition.

    ERIC Educational Resources Information Center

    Meyers, G. Douglas

    Composition teachers can learn much from the tradition of psychologist and researcher Carl R. Rogers. Placing the direction of the therapeutic process in the hands of the client, Rogers's work focuses on "potentiality," the idea that humans are primed with a potential for self-realization and are endowed with an actualizing tendency to…

  5. Carl: A Case Study of a Gifted Student with Challenging Social Behaviors

    ERIC Educational Resources Information Center

    Zapotocky, Robin

    2014-01-01

    Robin Zapotocky is a first-year teacher in a fifth-grade classroom at Cannaday Elementary in Mesquite ISD, Mesquite TX. She graduated from Baylor University in the gifted and elementary dual certificate program, and first met Carl when she was student teaching in a gifted and talented pullout program for third- and fourth-grade gifted students.…

  6. ``Orion, I Don't Love You'': The Astronomical Legacy of Carl Sandburg

    NASA Astrophysics Data System (ADS)

    Ricca, B.

    2013-04-01

    Can poetry provide an accurate means of representing the scientific universe? This paper looks at the astronomical poetry of Carl Sandburg and how the poet employs a scientific framework to deepen his work. Sandburg's method is then compared to a class project of middle school students who use his poetry (and their own) to learn and understand astronomical facts.

  7. Astronaut Carl Walz changes out film magazine on the IMAX camera

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut Carl E. Walz, mission specialist, changes out a film magazine on the IMAX camera. The camera was one of two IMAX cameras carried aboard the Discovery. The procedure was carried out in the middeck. A sleep restraint forms a backdrop for the action.

  8. Frontiers in Laser Cooling, Single-Molecule Biophysics, and Enrgy Science: A Talk by Carl Wieman

    ScienceCinema

    Wieman, Carl

    2016-07-12

    Carl Wieman presents a talk at Frontiers in Laser Cooling, Single-Molecule Biophysics and Energy Science, a scientific symposium honoring Steve Chu, director of Lawrence Berkeley National Laboratory and recipient of the 1997 Nobel Prize in Physics. The symposium was held August 30, 2008 in Berkeley.

  9. Critical Challenges in California Community Colleges: An Interview with Carl Ehmann

    ERIC Educational Resources Information Center

    Frost, Robert A.

    2009-01-01

    This interview took place in several meetings over a period of two weeks in late spring, 2008. Carl Ehmann had spent the past five months working with multiple California community college districts to resolve numerous, and multilevel, shortages in senior leadership positions. Robert A. Frost and Ehmann had come into contact through Frost's…

  10. Von Hippel's disease in association with von Recklinghausen's neurofibromatosis.

    PubMed Central

    Thomas, J V; Schwartz, P L; Gragoudas, E S

    1978-01-01

    Ten members of a large family who showed manifestations of either von Hippel-Lindau disease or von Recklinghausen's neurofibromatosis were examined. Three of 10 members were found to have retinal angiomas which had not been present on fundus examination 3 years previously. These angiomas were associated with ocular and systemic signs of neurofibromatosis. These cases show overlapping manifestations of different phakomatoses and provide support for the concept of a common aetiology for these diseases. Images PMID:101230

  11. von Braun and German Publisher

    NASA Technical Reports Server (NTRS)

    1969-01-01

    In this photograph, Guenter Ogger of Capitol Magazine, West Germany, greets Marshall Space Flight Center Director, Dr. Wernher von Braun. Mr. Ogger interviewed the famous rocket scientist for his magazine.

  12. Von Karman and JATO Team

    NASA Technical Reports Server (NTRS)

    1940-01-01

    Dr. Theodore von Karman (black coat) sketches out a plan on the wing of an airplane as his JATO engineering team looks on. From left to right: Dr. Clark B. Millikan, Dr.Martin Summerfield, Dr. Theodore von Karman, Dr. Frank J. Malina and pilot, Capt. Homer Boushey. Captain Boushey would become the first American to pilot an airplane that used JATO (Jet Assisted Take-Off) solid propellent rockets.

  13. The smooth entropy formalism for von Neumann algebras

    NASA Astrophysics Data System (ADS)

    Berta, Mario; Furrer, Fabian; Scholz, Volkher B.

    2016-01-01

    We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

  14. Henry Cavendish, Johann von Soldner, and the deflection of light

    NASA Astrophysics Data System (ADS)

    Will, Clifford M.

    1988-05-01

    The gravitational deflection of light based on Newtonian theory and the corpuscular model of light was calculated, but never published, around 1784 by Henry Cavendish, almost 20 years earlier than the first published calculation by Johann Georg von Soldner. The two results are slightly different because, while Cavendish treated a light ray emitted from infinity, von Soldner treated a light ray emitted from the surface of the gravitating body. At the first order of approximation, they agree with each other; both are one-half the value predicted by general relativity and confirmed by experiment.

  15. The smooth entropy formalism for von Neumann algebras

    SciTech Connect

    Berta, Mario; Furrer, Fabian; Scholz, Volkher B.

    2016-01-15

    We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

  16. Von Willebrand factor processing.

    PubMed

    Brehm, Maria A

    2017-01-31

    Von Willebrand factor (VWF) is a multimeric glycoprotein essential for primary haemostasis that is produced only in endothelial cells and megakaryocytes. Key to VWF's function in recruitment of platelets to the site of vascular injury is its multimeric structure. The individual steps of VWF multimer biosynthesis rely on distinct posttranslational modifications at specific pH conditions, which are realized by spatial separation of the involved processes to different cell organelles. Production of multimers starts with translocation and modification of the VWF prepropolypeptide in the endoplasmic reticulum to produce dimers primed for glycosylation. In the Golgi apparatus they are further processed to multimers that carry more than 300 complex glycan structures functionalized by sialylation, sulfation and blood group determinants. Of special importance is the sequential formation of disulfide bonds with different functions in structural support of VWF multimers, which are packaged, stored and further processed after secretion. Here, all these processes are being reviewed in detail including background information on the occurring biochemical reactions.

  17. Dr. Wernher Von Braun leads a tour of the S-IC checkout area.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Eberhard Rees, Charles Schultze, James Webb, Elmer Staats, Comptroller General of the United States, and Dr. Wernher Von Braun tour the S-IC checkout area in the Marshall Space Flight Center quality lab.

  18. Generalized Imitation and Orff-Schulwerk

    ERIC Educational Resources Information Center

    Ball, Thomas S.; Bitcon, Carol H.

    1974-01-01

    Carl Orff's procedure of using elemental music in learning through discovery (Schulwerk) was tested for its effect in developing generalized imitative behaviors in 16 severely retarded Ss (mean chronological age was 17.8 years for experimental Ss and 16.5 years for control Ss). (GW)

  19. A Dialogue with Carl Rogers: Cross-Cultural Challenges of Facilitating Person-Centered Groups in Africa.

    ERIC Educational Resources Information Center

    Hain-Hill, Alicia; Rogers, Carl R.

    1988-01-01

    Presents brainstorming dialogue with Carl Rogers which was held in January of 1987, shortly before Rogers's death. Explores basic challenges involved in a large-scale, cross-cultural application of person-centered group work in South Africa. (Author)

  20. Dr. von Braun with Gen. Ostrander, Dr. Rees, and Gen. Barclay

    NASA Technical Reports Server (NTRS)

    1959-01-01

    In this 1959 photo, taken at Cape Canaveral, Florida, Dr. von Braun (2nd from left) Director of the U.S. Army Ballistic Missile Agency's (ABMA) Development Operations Division, is shown conferring with Air Force Major General Donald R. Ostrander (left), on assignment at NASA as launch vehicle director; Dr. Eberhard Rees, deputy to Dr. von Braun, and Army Brigadier General John Barclay, commander of the ABMA.

  1. Feeling our way into empathy: Carl rogers, Heinz Kohut, and Jesus.

    PubMed

    Goodman, G

    1991-09-01

    Throughout their academic careers Carl Rogers and Heinz Kohut developed two contrasting definitions of empathy that influenced the ways in which both men sought to help their clients cope with emotional suffering. These two different understandings of empathy are contrasted to each other and finally compared with the understanding of empathy demonstrated in the teachings and actions of Jesus. It is hoped that through studying these ancient religious narratives we might be able to recover a deeper meaning of empathy.

  2. Carl Levin National Defense Authorization Act for Fiscal Year 2015

    THOMAS, 113th Congress

    Sen. Levin, Carl [D-MI

    2014-06-02

    06/02/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 402. (All Actions) Notes: For further action, see H.R.3979, which became Public Law 113-291 on 12/19/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance

    PubMed Central

    LaMonte, Gregory; Lim, Michelle Yi-Xiu; Wree, Melanie; Reimer, Christin; Nachon, Marie; Corey, Victoria; Gedeck, Peter; Plouffe, David; Du, Alan; Figueroa, Nelissa; Yeung, Bryan; Winzeler, Elizabeth A.

    2016-01-01

    ABSTRACT Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-stage parasites. Here, we show that pfcarl encodes a protein, with a predicted molecular weight of 153 kDa, that localizes to the cis-Golgi apparatus of the parasite in both asexual and sexual blood stages. Utilizing clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene introduction of 5 variants (L830V, S1076N/I, V1103L, and I1139K), we demonstrate that mutations in pfcarl are sufficient to generate resistance against the imidazolopiperazines in both asexual and sexual blood-stage parasites. We further determined that the mutant PfCARL protein confers resistance to several structurally unrelated compounds. These data suggest that PfCARL modulates the levels of small-molecule inhibitors that affect Golgi-related processes, such as protein sorting or membrane trafficking, and is therefore an important mechanism of resistance in malaria parasites. PMID:27381290

  4. BOOK REVIEW: Carl Christian Bruhns - Ein bedeutender Naturwissenschaftler in der zweiten Halfte des 19. Jahrhunderts

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Hansel, C.; Munzel, G.; Ilgauds, H.-J.; Borngen, M.

    2006-12-01

    The biography of the former member of the Saxonian Academy of Sciences, Carl Christian Bruhns, and appropiately published in their Transactions, originated from a series of lectures given some years ago. Gisela Munzel and Hans-Joachim Ilgauds, who have already written an authoritative history of Leipzig observatories, joined geophysicist Michael Borngen to describe various aspects of Bruhns' life and activities in different scientific fields. For the astronomical reader, Gisela Munzel's contribution is certainly the most rewarding one, and it covers almost the complete first half of the book. She not only describes Bruhns' astronomical career, but also supplies many details of his life. Having passed something equivalent to a junior high school, his father urged him to become apprentice in his own field, that of a locksmith. C.C. Bruhns became a mechanic in several companies in Berlin, and started also part-time work as a computer at Berlin Observatory in 1851. He soon was "discovered" by its director Johann Franz Encke, and became second assistant in mid-1852, first assistant in 1854 and observer in 1855. In mid-1856 he received his PhD on the topic of minor planets. A prize assignment on astronomical refraction developed into his habilitation thesis of 1859. When in 1857 the observer Heinrich d'Arrest left Leipzig Observatory, there were plans to replace him by an astronomer who would later also take over the post of the aging August Ferdinand Mobius. There were already plans to move the old Observatory on the tower of Pleissenburg castle to another location, when Bruhns was appointed observer and professor in April 1860. In Summer, construction of the new Observatory at Johannistal started, and it was inaugurated in late 1861. Munzel faithfully traces his work, his assistants and colleagues - Engelmann, Weinek, Zollner, and many more - , his activities in the founding of the Astronomische Gesellschaft, his work as a commissar of the ``Mitteleuropaische

  5. Report on von Willebrand Disease in Malaysia

    PubMed Central

    Periayah, Mercy Halleluyah; Halim, Ahmad Sukari; Saad, Arman Zaharil Mat; Yaacob, Nik Soriani; Karim, Faraizah Abdul

    2016-01-01

    BACKGROUND: Von Willebrand disease (vWD) is an inherited hemostatic disorder that affects the hemostasis pathway. The worldwide prevalence of vWD is estimated to be 1% of the general population but only 0.002% in Malaysia. AIM: Our present paper has been written to disclose the statistical counts on the number of vWD cases reported from 2011 to 2013. MATERIAL AND METHODS: This article is based on sociodemographic data, diagnoses and laboratory findings of vWD in Malaysia. A total of 92 patients were reported to have vWD in Malaysia from 2011 to 2013. RESULTS: Sociodemographic-analysis revealed that 60% were females, 63% were of the Malay ethnicity, 41.3% were in the 19-44 year old age group and 15.2% were from Sabah, with the East region having the highest registered number of vWD cases. In Malaysia, most patients are predominately affected by vWD type 1 (77.2%). Factor 8, von Willebrand factor: Antigen and vWF: Collagen-Binding was the strongest determinants in the laboratory profiles of vWD. CONCLUSION: This report has been done with great interest to provide an immense contribution from Malaysia, by revealing the statistical counts on vWD from 2011-2013. PMID:27275342

  6. Approximate von Neumann entropy for directed graphs.

    PubMed

    Ye, Cheng; Wilson, Richard C; Comin, César H; Costa, Luciano da F; Hancock, Edwin R

    2014-05-01

    In this paper, we develop an entropy measure for assessing the structural complexity of directed graphs. Although there are many existing alternative measures for quantifying the structural properties of undirected graphs, there are relatively few corresponding measures for directed graphs. To fill this gap in the literature, we explore an alternative technique that is applicable to directed graphs. We commence by using Chung's generalization of the Laplacian of a directed graph to extend the computation of von Neumann entropy from undirected to directed graphs. We provide a simplified form of the entropy which can be expressed in terms of simple node in-degree and out-degree statistics. Moreover, we find approximate forms of the von Neumann entropy that apply to both weakly and strongly directed graphs, and that can be used to characterize network structure. We illustrate the usefulness of these simplified entropy forms defined in this paper on both artificial and real-world data sets, including structures from protein databases and high energy physics theory citation networks.

  7. Von Hippel-Lindau Disease

    MedlinePlus

    Von Hippel-Lindau disease (VHL) is a rare, genetic disease that causes tumors and cysts to grow in your body. The tumors can be either ... and, in men, their genital tract. Symptoms of VHL vary and depend on the size and location ...

  8. [Carl Arthur Scheunert's experiments on human nutrition, 1938-1943: boundary transgressions of a scientist under national socialism].

    PubMed

    Joost, Hans-Georg

    2012-01-01

    Carl Arthur Scheunert (1879-1957) was a German scientist who supervised several studies with prisoners that were designed to assess the optimal vitamin and nutrient supply, and were conducted by his associate Karl-Heinz Wagner (1911-2007) from 1938 to 1943. This contribution describes the aims, results and conclusions of Scheunert's research 1923 to 1945 in comparison with the national and international vitamin research and its consequences for public health measures. Conditions and results of the human experiments are reconstructed and compared with similar studies performed in other countries. Burden as well as health risks for the study participants are assessed. In addition, it is discussed whether general rules for human experimentation were followed (e.g. informed consent and minimizing of health risks). Although the available documents support the conclusion that no deaths or lasting injuries were caused, the experiments violated ethical standards, in particular because of the conditions in the Waldheim prison including progressive deterioration of nutrition and health.

  9. [Was Klaus von Mantrei the teacher of Hans von Gersdorff?].

    PubMed

    Vollmuth, R

    1996-01-01

    One of the most popular representatives of surgery at the end of the middle ages and the beginning modern era is the Strassburgian surgeon Hans von Gersdorff. Still we do not know very much about his life and his surgical teachers. Only one meister Nicklaus, called Mulartzt, is mentioned as such by the remarks in Gersdorffs 'Feldbuch der Wundarznei', but till today this surgeon could not be identified in more detail. This article now holds the thesis, that meister Nicklaus is probably identical with Klaus von Matrei (Metry), a well-known surgeon of the late 15th century. That cannot be fully proved yet, but a number of coinciding characteristics between the two and some further indications, that are explained, seem so significant, that the thesis can hardly be doubted.

  10. Carl Neumann versus Rudolf Clausius on the propagation of electrodynamic potentials

    NASA Astrophysics Data System (ADS)

    Archibald, Thomas

    1986-09-01

    In the late 1860's, German electromagnetic theorists employing W. Weber's velocity-dependent force law were forced to confront the issue of energy conservation. One attempt to formulate a conservation law for such forces was due to Carl Neumann, who introduced a model employing retarded potentials in 1868. Rudolf Clausius quickly pointed out certain problems with the physical interpretation of Neumann's mathematical formalism. The debate between the two men continued until the 1880's and illustrates the strictures facing mathematical approaches to physical problems during this prerelativistic, pre-Maxwellian period.

  11. Carl Cohen's 'kind' arguments for animal rights and against human rights.

    PubMed

    Nobis, Nathan

    2004-01-01

    Carl Cohen's arguments against animal rights are shown to be unsound. His strategy entails that animals have rights, that humans do not, the negations of those conclusions, and other false and inconsistent implications. His main premise seems to imply that one can fail all tests and assignments in a class and yet easily pass if one's peers are passing and that one can become a convicted criminal merely by setting foot in a prison. However, since his moral principles imply that nearly all exploitive uses of animals are wrong anyway, foes of animal rights are advised to seek philosophical consolations elsewhere. I note that some other philosophers' arguments are subject to similar objections.

  12. A Contingent Affinity: Max Weber, Carl Schmitt, and the Challenge of Modern Politics.

    PubMed

    Magalhães, Pedro T

    2016-01-01

    The thesis that the theory of charismatic-plebiscitary democracy developed by Max Weber in the wake of the Weimar Republic was developed to its ultimate consequences by Carl Schmitt in the final crisis of Weimar has been hotly debated since it was first advanced in the 1950s. This paper proposes a fresh look at the controversy. By comparing both authors' concepts of politics in their relation to the problem of modernity, it argues that the Weber-Schmitt affair is neither a baseless legend nor a case of natural continuity. Instead, it should rather be understood in terms of a contingent affinity.

  13. Mistaken Identity and Mirror Images: Albert and Carl Einstein, Leiden and Berlin, Relativity and Revolution

    NASA Astrophysics Data System (ADS)

    van Dongen, Jeroen

    2012-06-01

    Albert Einstein accepted a "special" visiting professorship at the University of Leiden in the Netherlands in February 1920. Although his appointment should have been a mere formality, it took until October of that year before Einstein could occupy his special chair. Why the delay? The explanation involves a case of mistaken identity with Carl Einstein, Dadaist art, and a particular Dutch fear of revolutions. But what revolutions was one afraid of? The story of Einstein's Leiden chair throws new light on the reception of relativity and its creator in the Netherlands and in Germany.

  14. [Ars medica Anhaltina (II): Carl Ferdinand Graefe (1787-1840) and the Alexisbad spa].

    PubMed

    Kaiser, W; Völker, A

    1986-04-15

    In 1985 the spa Alexisbad in the Harz Mountains celebrated the 175th anniversary of its creation. Its establishment is to be seen in close connection with the activities of the subsequent Berlin professor in ordinary Carl Ferdinand Graefe (1787-1840) in Anhalt-Bernburg. The early development of the spa which for a certain time was fused with the Beringerbrunnen in Suderode is characterized by the activities of several engaged sanatory physicians whose spectre of task allows insights in the balneological organisation of the 19th century.

  15. Treatment of von Willebrand Disease.

    PubMed

    Curnow, Jennifer; Pasalic, Leonardo; Favaloro, Emmanuel J

    2016-03-01

    Congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS) reflect conditions caused by von Willebrand factor (VWF) deficiency and/or defects. VWD is the most common inherited bleeding disorder and AVWS arises from a variety of causes. Since VWF stabilizes and protects factor VIII (FVIII) in the circulation, this is also reduced in many patients with VWD. The treatment of VWD and AVWS therefore primarily entails replacement of VWF, and sometimes FVIII, to protect against bleeding. This may entail the use of VWF concentrates (currently plasma-derived) and/or FVIII concentrates (currently plasma-derived or more increasingly recombinant forms), and/or desmopressin to release endogenous VWF in subgroups of patients. For AVWS additional treatment of the underlying condition is also required. Adjunct therapies include antifibrinolytics. Globally, various formulations exist for both VWF and FVIII concentrates and are differentially available based on manufacturer marketing or regulatory approvals/clearances in different geographies. Also, guidelines for treatment of VWD vary for different localities and recombinant VWF is undergoing clinical trials. The current review provides an overview of the treatment of VWD as currently practiced in developed countries, and also provides a glimpse towards the future.

  16. In the footsteps of astronomers in Bremen and Lilienthal. (German Title: Auf den Spuren von Astronomen in Bremen und Lilienthal)

    NASA Astrophysics Data System (ADS)

    Langkavel, Arno

    When Bremen and Lilienthal are mentioned, people interested in the history of astronomy will first of all remember Wilhelm Olbers (1785-1840) and Johann Hieronymus Schroeter (1745-1816). In addition to them, Friedrich Wilhelm Bessel (1784-1846) and Carl Friedrich Gauß (1777-1855) have also left their traces. Two walks describe the main memorial sites, which are all outdoors and easily accessible to the general public.

  17. Dr. von Braun Briefing Walt Disney

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  18. Nichtlineare Rauschmodellierung von LC Tank VCOs

    NASA Astrophysics Data System (ADS)

    Thiessen, T.; Bremer, J.-K.; Mathis, W.

    2008-05-01

    Im Rahmen dieser Arbeit wird ein alternativer Ansatz zur Phasenrauschoptimierung von LC-Tank Oszillatoren (VCOs) unter Verwendung stochastischer Differentialgleichungen vorgestellt. Zunächst werden die linearen Ansätze von Leeson, Hajimiri und Lee analysiert und bewertet. Danach wird ein Konzept vorgestellt, mit dem man die Rauscheigenschaften von VCOs auf der Grundlage stochastischer Differentialgleichungen und Fokker-Planck-Gleichungen untersuchen kann. Ziel dieser Arbeit ist eine Beschreibung des Phasenrauschens auf der Basis einer nichtlinearen Rauschmodellierung, welche Parameter eines VCOs für eine Optimierung beinhaltet. Es wurde ein Matlab-Tool erstellt und die Funktionalität anhand von Simulationen verifiziert.

  19. [Carl Ludwig and his place in the history of kidney physiology].

    PubMed

    From, Jesper

    2015-01-01

    Only very little was known about the physiology of the kidneys until the middle of the 19th century. The turning point came in 1842 when the famous German physiologist and physician Carl Ludwig (1816-1895) presented a theory about a two-step process (filtration and reabsorption) leading to the excretion of urine. This paper turns the highlights on Ludwig and the period in which he lived. It also tells the story about the anatomical studies in the 17th century and the chemical approaches to urine and kidney physiology in the 18th century preceding the research of Carl Ludwig. The theory of filtration and reabsorption was opposed by another theory (the secretion theory) regarding the kidney as a gland, like for instance the salivary glands. The origin of this theory can be dated back to Marcello Malpighi (1628-1694) in the Renaissance, but it was carried further on by William Bowman (1816-1892) and especially Rudolph Heidenhain (1834-1897) in the 19th century. The research in the 1920's and 1930's marked the end of the fight between the two theories. It proofed that Ludwig was right and it gave him posthumously the recognition that he all the time had deserved.

  20. Carl Jung.

    PubMed

    Kyle, R A; Shampo, M A

    1978-11-17

    Physicians should be prepared to provide prophylactic medications for travelers to malarious areas and to treat patients with malaria. Chloroquine hydrochloride is the suppressive agent of choice for treatment of mild infections due to all species of malaria except for those due to chloroquine-resistant strains of Plasmodium falciparum. For treatment of severe infections with P falciparum and for treatment of all infections due to chloroquine-resistant strains of P falciparum quinine is the suppressive agent of choice. Chloroquine is also the prophylactic agent of choice for most travelers. To prevent infection with P vivax or P ovale, primaquine must also be given. A RBC glucose-6-phosphate dehydrogenase level should be obtained before administration of primaquine. For prophylaxis of chloroquine-resistant strains of P falciparum, no completely satisfactory regime is presently available in the United States.

  1. Reflexionseigenschaften von Windenergieanlagen im Funkfeld von Funknavigations- und Radarsystemen

    NASA Astrophysics Data System (ADS)

    Sandmann, S.; Divanbeigi, S.; Garbe, H.

    2015-11-01

    Die hier behandelte Untersuchung befasst sich mit den Störungen des elektrischen Feldes einer Doppler Very High Frequency Omnidirectional Radio Range Navigationsanlage (DVOR) in der Gegenwart von Windenergieanlagen (WEA). Hierfür wird die Feldstärke auf 25 konzentrischen Kreisbahnen, sog. Orbit Flights verschiedener Höhen und mit verschiedenen Radien rund um die DVOR-Anlage numerisch simuliert. Insbesondere werden die Einflüsse diverser Parameter der WEA wie deren Anzahl, Position, Rotorwinkel, Turmhöhe und Rotordurchmesser auf die Feldverteilung herausgestellt, sowie die Anwendbarkeit der Simulationsmethode Physical Optics (PO) durch Vergleich der Simulationsergebnisse mit denen der Multi Level Fast Multipol Method (MLFMM) untersucht.

  2. A backward view from 16S rRNA to archaea to the universal tree of life to progenotes: reminiscences of Carl Woese.

    PubMed

    Garrett, Roger A

    2014-01-01

    I first became aware of Carl Woese in the mid-1970s when he and George Fox criticized a few of the 16S rRNA oligonucleotide sequences emerging from Strasbourg in the 10-12 y RNA sequencing project of the first 16S rRNA from Escherichia coli, some of which we were using for assembling RNA binding sites of ribosomal proteins. When I realized that they were attempting to sequence 16S rRNAs from a range of bacteria to classify them phylogenetically, I seriously questioned their sanity. Not because of the goal, which was admirable, but because of the sheer technical difficulty, and slowness, of sequencing large RNA molecules using the original Sanger RNA sequencing method, not to mention the health hazards of regularly preparing rRNA using 20-30 mCi [ (32)P]. My view changed radically, however, with their subsequent prediction of 5S rRNA secondary structures using a phylogenetic approach. Previously, the molecular biology community had been competing to generate the maximum numbers of base pairs in the model RNA molecule E. coli 5S RNA when Fox and Woese introduced the concept of compensatory base changes based on phylogeny for defining secondary structure and applied it to 5S RNA, they found evidence for only about 50% base pairing. This approach had previously been used for tRNA secondary structure predictions but its more general significance had never been acknowledged. Carl subsequently persuaded Harry Noller to apply the same method to predicting secondary structures of the large rRNAs.

  3. The molecular characterization of von Willebrand disease: good in parts.

    PubMed

    James, P D; Lillicrap, D

    2013-04-01

    Since the cloning of the gene that encodes von Willebrand factor (VWF), 27 years ago, significant progress has been made in our understanding of the molecular basis of the most common inherited bleeding disorder, von Willebrand disease (VWD). The molecular pathology of this condition represents a range of genetic mechanisms, some of which are now very well characterized, and others that are still under investigation. In general, our knowledge of the molecular basis of type 2 and 3 VWD is now well advanced, and in some instances this information is being used to enhance clinical management. In contrast, our understanding of the molecular pathogenesis of the most common form of VWD, type 1 disease, is still at an early stage, with preliminary evidence that this phenotype involves a complex interplay between environmental factors and the influence of genetic variability both within and outside of the VWF locus.

  4. Interaction of Platelet Membrane Receptors with von Willebrand Factor, Ristocetin, and the Fc Region of Immunoglobulin G

    PubMed Central

    Moore, Anne; Ross, Gordon D.; Nachman, Ralph L.

    1978-01-01

    The agglutination of human platelets by ristocetin and von Willebrand factor was inhibited by aggregated immunoglobulin (Ig)G and by Fc fragments of IgG, but not by Fab, F(ab′)2 or pFc fragments of IgG. Because this inhibition occurred with formalin-fixed platelets as well as with normal platelets, a generalized aggregation of fluid membrane components by Fc fragments was not responsible for this inhibition of ristocetin and von Willebrand factor-induced agglutination. Reciprocal inhibition of platelet Fc receptors was produced by prior incubation of platelets with von Willebrand factor and ristocetin. Sucrose density gradient ultracentrifugation studies demonstrated that aggregated IgG did not form fluid-phase complexes with von Willebrand factor and ristocetin. Furthermore, passage of von Willebrand factor and ristocetin through a column of immobilized heat-aggregated IgG did not alter platelet agglutinating activity which indicates that aggregated IgG did not inactivate von Willebrand factor or ristocetin. Thus, it was likely that the IgG-mediated interference with platelet agglutination by ristocetin and von Willebrand factor did not occur in the fluid phase but at the platelet surface. These studies suggest that the platelet membrane Fc receptor may be either a part of, or sterically related to, the membrane glycoprotein I complex that interacts with von Willebrand factor, and that occupation of one of these surface components blocks the availability of the other. PMID:309473

  5. Dr. Wernher Von Braun at a picnic.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, director of the Marshall Space Flight Center, stakes claim to a table for the picnic celebrating man's first lunar landing. With Dr. Von Braun are his wife, Maria (seated, right), and son, Peter (back to camera). His daughter, Margrit, was also present, but is hidden from view by friends in this view.

  6. Dr. Wernher Von Braun greeting dignitaries.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun, left, greets vice president Spiro T. Agnew in the Launch Control Center for the Apollo 14 mission. Between Dr. Von Braun and Mr. Agnew are their Royal Highnesses, The Prince and Princess of Spain. The royal visitors greeted the launch control team in th enter after the launch of Apollo 14.

  7. Dr. von Braun Tries Out the NBS

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Marshall Space Flight Center (MSFC) Director, Dr. von Braun, is shown fitted with suit and diving equipment as he prepares for a tryout in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  8. Walt Disney and Dr. Wernher von Braun

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

  9. Carl Rogers' Responses in the 17th Session with Miss Mun: Comments from a Process-Experiential and Psychoanalytic Perspective.

    ERIC Educational Resources Information Center

    Gundrum, Monica; Lietaer, Germain; Van Hees-Matthijssen, Christiane

    1999-01-01

    Reproduces the transcript of one of Carl Rogers' filmed therapeutic sessions with Miss Mun, followed by an empirical and clinical-qualitative analysis. Five task oriented processes are examined in detail: the evocative impact of reflections of feeling; empathic affirmation as a marker of intense vulnerability; focusing reflections; working with…

  10. The Unifying Function of Affect: Founding a Theory of Psychocultural Development in the Epistemology of John Dewey and Carl Jung

    ERIC Educational Resources Information Center

    Dunlap, Peter T.

    2012-01-01

    In this paper I explore the shared interest of John Dewey and Carl Jung in the developmental continuity between biological, psychological, and cultural phenomena. Like other first generation psychological theorists, Dewey and Jung thought that psychology could be used to deepen our understanding of this continuity and thus gain a degree of control…

  11. STUDY TO DETERMINE THE FEASIBILITY OF ADAPTING THE CARL ORFF APPROACH TO ELEMENTARY SCHOOLS IN AMERICA. FINAL REPORT.

    ERIC Educational Resources Information Center

    GLASGOW, ROBERT B.; HAMREUS, DALE G.

    A STUDY WAS CONDUCTED TO DETERMINE THE FEASIBILITY OF ADAPTING FOR USE IN THE ELEMENTARY SCHOOLS OF AMERICA THE MUSIC TEACHING TECHNIQUES DEVELOPED BY THE GERMAN COMPOSER AND TEACHER, CARL ORFF. THE POPULATION OF AN ELEMENTARY SCHOOL WAS EMPLOYED IN THE STUDY. FIFTEEN STUDENTS FROM EACH CLASSROOM (TOTALING 180 STUDENTS) WERE RANDOMLY SELECTED FOR…

  12. Dr. Wernher von Braun Laid to Rest

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

  13. Dr. Wernher von Braun In His Office

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. This photo depicts von Braun in his office at MSFC.

  14. Die Struktur der Allgemeinbildung im Kerncurriculum moderner Bildungssysteme. Ein Vorschlag zur bildungstheoretischen Rahmung von PISA (The Structure of General Education in the Core Curriculum of Modern Educational Systems. A Proposal for a Framework for PISA Based on Educational Theory).

    ERIC Educational Resources Information Center

    Benner, Dietrich

    2002-01-01

    Draws on a theory of education for a Program for International Student Assessment (PISA) framework based on the structure of general education in modern educational systems. Shows that pedagogical research on school and instruction is formed by the relationship of instruction, didactics, curricular development, and achievement control. (CAJ)

  15. Alloantibodies in von Willebrand disease.

    PubMed

    James, Paula D; Lillicrap, David; Mannucci, Pier M

    2013-08-01

    The development of alloantibodies against von Willebrand factor (VWF) represents a rare but serious complication of treatment of von Willebrand disease (VWD), occurring in ~5% to 10% of type 3 VWD patients. Affected patients can present with a range of symptoms, including lack or loss of hemostatic response to infused VWF concentrates up to anaphylactic reactions in rare cases. It is classically reported in multitransfused patients and occurs most frequently in patients with partial or complete VWF gene deletions. A positive family history of anti-VWF antibodies also appears to be a risk factor. There is a lack of standardization of laboratory methods for antibody identification and characterization. Issues of variability in laboratory approaches as well as the rarity of the complication act as a barrier to future studies. Recombinant factor VIII as well as bypassing agents and immune tolerance have been reported as effective treatments; however, aside from case reports, little exists in the literature to guide management. The imminent clinical availability of recombinant VWF has prompted a resurgence of interest in this area. Additional study is warranted to address the deficiencies in our understanding of this treatment complication.

  16. Clearance of von Willebrand factor.

    PubMed

    Denis, Cécile V; Christophe, Olivier D; Oortwijn, Beatrijs D; Lenting, Peter J

    2008-02-01

    The life cycle of von Willebrand factor (VWF) comprises a number of distinct steps, ranging from the controlled expression of the VWF gene in endothelial cells and megakaryocytes to the removal of VWF from the circulation. The various aspects of VWF clearance have been the objects of intense research in the last few years, stimulated by observations that VWF clearance is a relatively common component of the pathogenesis of type 1 von Willebrand disease (VWD). Moreover, improving the survival of VWF is now considered as a viable therapeutic strategy to prolong the half-life of factor VIII in order to optimise treatment of haemophilia A. The present review aims to provide an overview of recent findings with regard to the molecular basis of VWF clearance. A number of parameters have been identified that influence VWF clearance, including its glycosylation profile and a number of VWF missense mutations. In addition, in-vivo studies have been used to identify cells that contribute to the catabolism of VWF, providing a starting point for the identification of receptors that mediate the cellular uptake of VWF. Finally, we discuss recent data describing chemically modification of VWF as an approach to prolong the half-life of the VWF/FVIII complex.

  17. Similarities between Prescott Lecky's theory of self-consistency and Carl Rogers' self-theory.

    PubMed

    Merenda, Peter F

    2010-10-01

    The teachings of Prescott Lecky on the self-concept at Columbia University in the 1920s and 1930s and the posthumous publications of his book on self-consistency beginning in 1945 are compared with the many publications of Carl Rogers on the self-concept beginning in the early 1940s. Given that Rogers was a graduate student at Columbia in the 1920s and 1930s, the striking similarities between these two theorists, as well as claims attributed to Rogers by Rogers' biographers and writers who have quoted Rogers on his works relating to self-theory, strongly suggest that Rogers borrowed from Lecky without giving him the proper credit. Much of Rogers' writings on the self-concept included not only terms and concepts which were original with Lecky, but at times these were actually identical.

  18. Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora

    PubMed Central

    Saucedo-Morales, Julio; Loera-González, Pablo

    2013-01-01

    We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects. PMID:25685436

  19. Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora

    NASA Astrophysics Data System (ADS)

    Saucedo-Morales Julio; Loera-González, Pablo

    2013-05-01

    We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects.

  20. Education and public outreach at the Carl Sagan Solar Observatory of the University of Sonora.

    PubMed

    Saucedo-Morales, Julio; Loera-González, Pablo

    2013-05-01

    We discuss the importance of small solar observatories for EPO (Education and Public Outreach), mentioning why they are relevant and what kind of equipment and software require. We stress the fact that technological advances have made them affordable and that they should be widely available. This work is a result of our experience with one: The Carl Sagan Solar Observatory (CSSO). We briefly describe its status and the solar data obtained daily with students participation. We present examples of the data obtained in the visible, Ca II and two in Hα. Data which is widely used for education. Finally we talk about the capability for remote operation as an open invitation for collaboration in educational and scientific projects.

  1. [From the legacy of Carl Koller. Notations on his experiments with cocaine].

    PubMed

    Goerig, M

    2015-06-01

    The history of local anesthesia began with the discovery of the anesthetic properties of cocaine by the physician Carl Koller from Vienna 130 years ago. After he had realized the options for painless surgery using this substance, he analyzed cocaine in detail from this point of view and evaluated the drug's significance in animal experiments, in self-experiments and in colleagues. The findings of his experiments were accurately recorded by Koller and after his death remained in the possession of the family for a long time until his daughter Hortense Becker-Koller handed these documents over to the Library of Congress in Washington. These recordings were recently studied and will now be presented to the public for the first time ever.

  2. [Matter and spirit: the unconscious in Carl Gustav Carus's psychology (1779-1868)].

    PubMed

    Montiel, L

    1997-01-01

    Carl Gustav Carus, one of the originators of a doctrine centered on the unconscious, is an interesting figure from current viewpoints. The doctrine he espoused was psychological, but in addition, the author sought foundations for his thinking in the biological knowledge of his time. The unconscious that Carus postulated was simultaneously biological, material and psychological in nature. Thus the history of psychism--the history of the soul--was related with the individual's and the species's biological history. From this perspective the unconscious was recognized as an indispensable element of rational thought. This theory, which recalls in many aspects that of C.G. Jung, made possible the medical study of psychic life and the revaluation of unconscious factors of psychism which were usually denigrated by modern anthropologists and moralists.

  3. Carl Düsing (1884) on the regulation of the sex-ratio.

    PubMed

    Edwards, A W

    2000-11-01

    In three publications in 1883 and 1884 Carl Düsing of Jena gave a mathematical account of the influence of natural selection on the sex ratio based on the same argument that Darwin had advanced in The Descent of Man (1871). The argument thus became quite well known, being included in the principal books on the subject around the turn of the century, as well as in the Encyclopaedia Britannica, references to Düsing being given. By 1930, when Fisher gave a verbal account of the argument in The Genetical Theory of Natural Selection, he saw no need to give references, and no other book of the period treated the subject, as a result of which Düsing's contribution became lost to view. We here give the important paragraphs of Düsing's mathematical account, translated into English.

  4. The British Interplanetary Society - Val Cleaver and Wernher von Braun

    NASA Astrophysics Data System (ADS)

    Willhite, I. P.

    This article is concerned with the early relationship between Wernher von Braun and the British Interplanetary Society (BIS). The BIS/Wernher von Braun/Val Cleaver correspondence files located here at the US Space & Rocket Center in Huntsville, Alabama are unparalleled. As one reads the stimulating comments between Cleaver and von Braun, the need to share their thoughts prevails. Following is an excerpt from one letter that whets ones appetite for more. 10 June 1951 Cleaver writes, “I'm so glad you enjoyed my last letter, and look forward to your promised further contribution to our discussion of the ethics of science in general and astronautics in particu- lar. As regards the one particular point on which you found yourself unable to hold your fire, I should say there are really two distinct issues at stake:. . .” This article attempts to represent the best of the letters as they goad each other on scientific principles, means to prevent wars, and other philosophic ideas.

  5. A double commutant theorem for Murray–von Neumann algebras

    PubMed Central

    Liu, Zhe

    2012-01-01

    Murray–von Neumann algebras are algebras of operators affiliated with finite von Neumann algebras. In this article, we study commutativity and affiliation of self-adjoint operators (possibly unbounded). We show that a maximal abelian self-adjoint subalgebra of the Murray–von Neumann algebra associated with a finite von Neumann algebra is the Murray–von Neumann algebra , where is a maximal abelian self-adjoint subalgebra of and, in addition, is . We also prove that the Murray–von Neumann algebra with the center of is the center of the Murray–von Neumann algebra . Von Neumann’s celebrated double commutant theorem characterizes von Neumann algebras as those for which , where , the commutant of , is the set of bounded operators on the Hilbert space that commute with all operators in . At the end of this article, we present a double commutant theorem for Murray–von Neumann algebras. PMID:22543165

  6. Indikatorenbasierte Bewertung von Entwurfsentscheidungen auf Systemebene

    NASA Astrophysics Data System (ADS)

    Freier, M.; Wenzler, A.; Mayer, T.; Gerlach, J.; Rosenstiel, W.

    2013-07-01

    Bei dem Entwurf von anwendungsspezifischen integrierten Schaltungen muss ein Entwickler zusätzliche Funktionen integrieren und die zunehmende Komplexität bewältigen. Für die Reduzierung der Kosten bleibt weiterhin die Verkürzung der benötigten Entwicklungszeit ein Ziel. Ein entscheidender Faktor dabei ist die zuverlässige Absicherung von Entwurfsentscheidungen in einer frühen Entwurfsphase. In der vorliegenden Arbeit wird eine Methode vorgestellt, die eine Bewertung von Entwurfsentscheidungen bei Systemmodellen mittels automatisch ermittelter Indikatoren ermöglichen soll. Die Systemmodelle können mit der Entwurfsumgebung MATLAB/Simulink oder in SystemC beschrieben sein.

  7. Quantum control by von Neumann measurements

    NASA Astrophysics Data System (ADS)

    Pechen, Alexander; Il'in, Nikolai; Shuang, Feng; Rabitz, Herschel

    2006-11-01

    A general scheme is presented for controlling quantum systems using evolution driven by nonselective von Neumann measurements, with or without an additional tailored electromagnetic field. As an example, a two-level quantum system controlled by nonselective quantum measurements is considered. The control goal is to find optimal system observables such that consecutive nonselective measurement of these observables transforms the system from a given initial state into a state which maximizes the expected value of a target operator (the objective). A complete analytical solution is found including explicit expressions for the optimal measured observables and for the maximal objective value given any target operator, any initial system density matrix, and any number of measurements. As an illustration, upper bounds on measurement-induced population transfer between the ground and the excited states for any number of measurements are found. The anti-Zeno effect is recovered in the limit of an infinite number of measurements. In this limit the system becomes completely controllable. The results establish the degree of control attainable by a finite number of measurements.

  8. Richard von Volkmann: surgeon and Renaissance man.

    PubMed

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R; Mubarak, Scott J

    2008-02-01

    Richard von Volkmann (1830-1889), one of the most important surgeons of the 19(th) century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867-1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the "antiseptic technique" to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann's contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children's fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics.

  9. Childhood Picture of Dr. von Braun

    NASA Technical Reports Server (NTRS)

    1912-01-01

    This is a childhood picture of Dr. von Braun (center) with his brothers. Dr. Wernher von Braun was born in Wirsitz, Germany, March 23, 1912. His childhood dreams of marned space flight were fulfilled when giant Saturn rockets, developed under his direction at NASA's Marshall Space Flight Center, boosted the manned Apollo spacecraft to the Moon. His life was dedicated to expanding man's knowledge through the exploration of space.

  10. Dr. von Braun With Management Team

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun is shown in this photograph, which was probably taken in the early 1960s, with members of his management team. Pictured from left to right are, Werner Kuers, Director of the Manufacturing Engineering Division; Dr. Walter Haeussermarn, Director of the Astrionics Division; Dr. William Mrazek, Propulsion and Vehicle Engineering Division; Dr. von Braun; Dieter Grau, Director of the Quality Assurance Division; Dr. Oswald Lange, Director of the Saturn Systems Office; and Erich Neubert , Associate Deputy Director for Research and Development.

  11. [Ludwig von Riediger (Ludwik Rydygier). A great surgeon forgotten in Germany].

    PubMed

    Zajaczkowski, T; Döhler, R; Zamann, A M

    2013-07-01

    Riediger was born in West Prussia and studied medicine in Greifswald under Carl Hueter. Having accomplished his surgical training in Gdańsk, Greifswald and Jena in 1879 he built an outstanding private hospital in Chełmno where he wrote important publications in the Polish language. In 1887 he polonized his name to Rydygier to obtain Bavarian citizenship and succeeded Johann von Mikulicz as the chair of surgery at the Jagiellonian University. In 1897 he was given the chair in surgery at the University of Lviv and in 1901/02 he became rector. In World War I he served in the Austrian and Polish Armies. In the Polish-Soviet War (1920) he played an active role against the invading Bolshevic (Soviet) army as head of the medical service for the Polish army in Pomerania. After 23 years in Lviv he became professor emeritus. Before returning to West Prussia he lost his fortune due to the stock market crash in 1920 and died at 70 years old. Riediger founded the Polish Society of Surgeons and was cofounder of the German Association of Urology. His descendents formed a dynasty of surgeons in Brazil.

  12. Severe hyponatraemia secondary to desmopressin therapy in von Willebrand's disease.

    PubMed

    Bertholini, D M; Butler, C S

    2000-04-01

    A 42-year-old female with von Willebrand's disease was managed with desmopressin and tranexamic acid to aid haemostasis following a vaginal hysterectomy. Severe acute hyponatraemia (134 to 108 mmol/l) developed over two days, culminating in a generalized tonic-clonic seizure and cerebral oedema. Fluid restriction, cessation of desmopressin and hypertonic saline administration led to a full recovery. Desmopressin is known to reduce free water elimination and produce hyponatraemia, but its extent and rate of development in this patient was surprising. Close monitoring of serum sodium and fluid balance is recommended in these patients.

  13. On the enduring and substantial influence of Carl Rogers' not-quite necessary nor sufficient conditions.

    PubMed

    Farber, Barry A

    2007-09-01

    Carl Rogers' 1957 paper (see record 2007-14639-002) is arguably the most successful of his many attempts to clarify and render testable the ideas behind client-centered therapy. While each of the conditions that Rogers postulated has been linked to positive therapeutic outcome, taken together they have never been conclusively proved (nor disproved) to be either necessary or sufficient for positive outcome. Nevertheless, the overriding "take-home" message in this classic paper--that the therapist's attitude and caring presence is critical for therapeutic success--is one that has had virtually unparalleled influence in every segment of the psychotherapeutic community. Clinical and theoretical innovations in the psychoanalytic community serve as examples of the following proposition: that Rogers' concepts, while accepted more than ever by a remarkably wide variety of psychotherapists, remain essentially unacknowledged as originating with him or in the tradition of humanistic and client-centered therapy. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

  14. Using Carl Rogers' person-centered model to explain interpersonal relationships at a school of nursing.

    PubMed

    Bryan, Venise D; Lindo, Jascinth; Anderson-Johnson, Pauline; Weaver, Steve

    2015-01-01

    Faculty members are viewed as nurturers within the academic setting and may be able to influence students' behaviors through the formation of positive interpersonal relationships. Faculty members' attributes that best facilitated positive interpersonal relationships according to Carl Rogers' Person-Centered Model was studied. Students (n = 192) enrolled in a 3-year undergraduate nursing program in urban Jamaica were randomly selected to participate in this descriptive cross-sectional study. A 38-item questionnaire on interpersonal relationships with nursing faculty and students' perceptions of their teachers was utilized to collect data. Factor analysis was used to create factors of realness, prizing, and empathetic understanding. Multiple linear regression analysis on the interaction of the 3 factors and interpersonal relationship scores was performed while controlling for nursing students' study year and age. One hundred sixty-five students (mean age: 23.18 ± 4.51years; 99% female) responded. The regression model explained over 46% of the variance. Realness (β = 0.50, P < .001) was the only significant predictor of the interpersonal relationship scores assigned by the nursing students. Of the total number of respondents, 99 students (60%) reported satisfaction with the interpersonal relationships shared with faculty. Nursing students' perception of faculty members' realness appeared to be the most significant attribute in fostering positive interpersonal relationships.

  15. Inductive reasoning in medicine: lessons from Carl Gustav Hempel's 'inductive-statistical' model.

    PubMed

    Gandjour, Afschin; Lauterbach, Karl Wilhelm

    2003-05-01

    The purpose of this paper is to discuss both the fundamental requirements of sound scientific explanations and predictions and common fallacies that occur in explaining and predicting medical problems. To this end, the paper presents Carl Gustav Hempel's 'covering-law' model (1948 and 1962) and reviews some of the criticism of the model. The strength of Hempel's model is that it shows that inductive arguments, when applied with the requirement of maximal specificity, can serve as explanations as well as predictions. The major weakness of the 'covering-law' model, its inability to portray causal relatedness, has been addressed by philosophers such as Wesley Salmon. While few philosophers today agree with the 'covering-law' model in its original formulation, there is widespread consensus that the law has made a central contribution to describing the fundamental requirements of sound scientific explanations. Applying this model and its revisions in the medical context may help uncover potentially undetected fallacies in reasoning when explaining and predicting medical problems.

  16. Carl Wilhelm Scheele, the discoverer of oxygen, and a very productive chemist.

    PubMed

    West, John B

    2014-12-01

    Carl Wilhelm Scheele (1742-1786) has an important place in the history of the discovery of respiratory gases because he was undoubtedly the first person to prepare oxygen and describe some of its properties. Despite this, his contributions have often been overshadowed by those of Joseph Priestley and Antoine Lavoisier, who also played critical roles in preparing the gas and understanding its nature. Sadly, Scheele was slow to publish his discovery and therefore Priestley is rightly recognized as the first person to report the preparation of oxygen. This being said, the thinking of both Scheele and Priestley was dominated by the phlogiston theory, and it was left to Lavoisier to elucidate the true nature of oxygen. In addition to his work on oxygen, Scheele was enormously productive in other areas of chemistry. Arguably he discovered seven new elements and many other compounds. However, he kept a low profile during his life as a pharmacist, and he did not have strong links with contemporary prestigious institutions such as the Royal Society in England or the French Académie des Sciences. He was elected to the Royal Swedish Academy of Science but only attended one meeting. Partly as a result, he remains a somewhat nebulous figure despite the critical contribution he made to the history of respiratory gases and his extensive researches in other areas of chemistry. His death at the age of 43 may have been hastened by his habit of tasting the chemicals that he worked on.

  17. Carl Woese's vision of cellular evolution and the domains of life

    PubMed Central

    Koonin, Eugene V

    2014-01-01

    In a series of conceptual articles published around the millennium, Carl Woese emphasized that evolution of cells is the central problem of evolutionary biology, that the three-domain ribosomal tree of life is an essential framework for reconstructing cellular evolution, and that the evolutionary dynamics of functionally distinct cellular systems are fundamentally different, with the information processing systems “crystallizing” earlier than operational systems. The advances of evolutionary genomics over the last decade vindicate major aspects of Woese’s vision. Despite the observations of pervasive horizontal gene transfer among bacteria and archaea, the ribosomal tree of life comes across as a central statistical trend in the “forest” of phylogenetic trees of individual genes, and hence, an appropriate scaffold for evolutionary reconstruction. The evolutionary stability of information processing systems, primarily translation, becomes ever more striking with the accumulation of comparative genomic data indicating that nearly allof the few universal genes encode translation system components. Woese’s view on the fundamental distinctions between the three domains of cellular life also withstand the test of comparative genomics, although his non-acceptance of symbiogenetic scenarios for the origin of eukaryotes might not. Above all, Woese’s key prediction that understanding evolution of microbes will be the core of the new evolutionary biology appears to be materializing. PMID:24572480

  18. Beyond synchronicity: the worldview of Carl Gustav Jung and Wolfgang Pauli.

    PubMed

    Donati, Marialuisa

    2004-11-01

    While exploring the phenomena of synchronicity, Carl Gustav Jung became acquainted with the quantum physicist Wolfgang Pauli and eventually began a collaboration with him. During that collaboration Jung's study of synchronistic phenomena underwent a considerable change; prior to the collaboration, Jung had stressed mainly the phenomenological and empirical features of synchronistic phenomena, while in association with Pauli, he focused his attention upon their ontological, archetypal character. Pauli, on the other hand, became increasingly sensitive to the philosophical aspects concerning the unconscious. Jung and Pauli's common reflections went far beyond psychology and physics, entering into the realm where the two areas meet in the philosophy of nature. In fact, as a consequence of their collaboration, synchronicity was transformed from an empirical concept into a fundamental explanatory-interpretative principle, which together with causality could possibly lead to a more complete worldview. Exploring the problematic character of the synchronicity concept has a heuristic value because it leads to the reconsideration of the philosophical issues that drove Jung and Pauli to clear up the conceptual background of their thoughts. Within the philosophical worldview arising from Jung and Pauli's discussions about synchronicity, there are many symbolic aspects that go against mainstream science and that represent a sort of criticism to some of the commonly held views of present day science.

  19. Education in regional anesthesia: caseloads, simulation, journals, and politics: 2011 Carl Koller Lecture.

    PubMed

    Neal, Joseph M

    2012-01-01

    This special article is an essay version of the European Society of Regional Anaesthesia and Pain Therapy 2011 Carl Koller Award lecture. Historically, evaluations of a trainee's regional anesthesia learning focused on caseload numbers. The deficiency of this unidimensional approach is that case numbers alone say little about the resident's mastery of the nontechnical aspects of regional anesthesiology. Simulation can refine technical skills, but also expands the teaching paradigm to include management of rare complications. Teachers are further challenged by requirements to incorporate systems-based practice topics, including the optimization of operating room efficiency and patient safety. Journals play an important role in regional anesthesia education for both trainees and mature anesthesiologists. Editorial boards build valuable educational foundations by providing critical analysis of new technologies and sponsoring practice advisories. Subspecialty societies such as European Society of Regional Anaesthesia and Pain Therapy and the American Society of Regional Anesthesia and Pain Medicine foster regional anesthesia education through their efforts to define curricula, produce guidelines, and promote international collaboration.

  20. [Biology of von Willebrand factor].

    PubMed

    Girma, Jean-Pierre

    2006-01-01

    Von Willebrand factor (VWF) is a multimeric glycoprotein synthesized by megakaryocytes and endothelial cells. It is stored in platelets and endothelial cells and secreted towards subendothelium and plasma. VWF multimers consist of linear arrangements of identical subunits with a molecular weight of 270 kDa. The longest multimers reach more than 20 x 10(6) Da in storage granules. In the circulation, the multimer size is limited by the specific protease ADAMTS13. In primary hemostasis, VWF plays a key role as a molecular bridge in adhesion between platelets and subendothelium and between platelets during their aggregation. These functions, which involve the interaction with platelet glycoprotein lb, are mainly enhanced by VWF immobilization onto hydrophobic surfaces (collagen, cell membrane) and by high shear rates found in microcirculation and stenosed arteries. In these functions, the higher molecular weight forms are the most efficient. Under such hemodynamic conditions, proteolytic activity of ADAMTS13 is also optimal and limits the multimer size to about 15 x 10(6) Da as soon as their secretion. Thus ADAMTS13 appears as a key physiologic regulator of the VWF platelet functions. In the microcirculation, the lack of ADAMTS13 activity can result in the formation of VWF-rich platelet aggregates responsible for thrombotic thrombocytopenic purpura.

  1. Von Karman re-visited

    NASA Astrophysics Data System (ADS)

    McEligot, Donald M.; Nolan, Kevin P.; Walsh, Edmond J.

    2012-11-01

    A number of authors have presented extended versions of the integral momentum equation, allowing for perturbations or fluctuations in the boundary layer. ``Conventional wisdom'' is that these added terms can be neglected and one can apply the von Karman version directly. For two-dimensional turbulent boundary layers at high Reynolds numbers, experience shows this assumption to be reasonable. However, recent examination of entropy generation in bypass transition with zero pressure gradient shows a term for turbulence energy convection can be important in determining the energy dissipation coefficient [Walsh et al., JFE 2011]. The present study employs the direct numerical simulations of Zaki and Durbin [JFM 2006] for bypass transition with streamwise pressure gradients to quantify the additional normal stress term when estimating the skin friction coefficient via a momentum balance. It is found that this term becomes noticeable in the pre-transitional laminar boundary layer and can exceed forty per cent of Cf in the transition region. Thus, it should be included in such calculations. Partly supported by U. S. DoE EPSCoR office.

  2. An MRI Von Economo - Koskinas atlas.

    PubMed

    Scholtens, Lianne H; de Reus, Marcel A; de Lange, Siemon C; Schmidt, Ruben; van den Heuvel, Martijn P

    2016-12-28

    The cerebral cortex displays substantial variation in cellular architecture, a regional patterning that has been of great interest to anatomists for centuries. In 1925, Constantin von Economo and George Koskinas published a detailed atlas of the human cerebral cortex, describing a cytoarchitectonic division of the cortical mantle into over 40 distinct areas. Von Economo and Koskinas accompanied their seminal work with large photomicrographic plates of their histological slides, together with tables containing for each described region detailed morphological layer-specific information on neuronal count, neuron size and thickness of the cortical mantle. Here, we aimed to make this legacy data accessible and relatable to in vivo neuroimaging data by constructing a digital Von Economo - Koskinas atlas compatible with the widely used FreeSurfer software suite. In this technical note we describe the procedures used for manual segmentation of the Von Economo - Koskinas atlas onto individual T1 scans and the subsequent construction of the digital atlas. We provide the files needed to run the atlas on new FreeSurfer data, together with some simple code of how to apply the atlas to T1 scans within the FreeSurfer software suite. The digital Von Economo - Koskinas atlas is easily applicable to modern day anatomical MRI data and is made publicly available online.

  3. The von Neumann model of measurement in quantum mechanics

    SciTech Connect

    Mello, Pier A.

    2014-01-08

    We describe how to obtain information on a quantum-mechanical system by coupling it to a probe and detecting some property of the latter, using a model introduced by von Neumann, which describes the interaction of the system proper with the probe in a dynamical way. We first discuss single measurements, where the system proper is coupled to one probe with arbitrary coupling strength. The goal is to obtain information on the system detecting the probe position. We find the reduced density operator of the system, and show how Lüders rule emerges as the limiting case of strong coupling. The von Neumann model is then generalized to two probes that interact successively with the system proper. Now we find information on the system by detecting the position-position and momentum-position correlations of the two probes. The so-called 'Wigner's formula' emerges in the strong-coupling limit, while 'Kirkwood's quasi-probability distribution' is found as the weak-coupling limit of the above formalism. We show that successive measurements can be used to develop a state-reconstruction scheme. Finally, we find a generalized transform of the state and the observables based on the notion of successive measurements.

  4. Sulfation of von Willebrand factor

    SciTech Connect

    Carew, J.A.; Browning, P.J.; Lynch, D.C. )

    1990-12-15

    von Willebrand factor (vWF) is a multimeric adhesive glycoprotein essential for normal hemostasis. We have discovered that cultured human umbilical vein endothelial cells incorporate inorganic sulfate into vWF. Following immunoisolation and analysis by polyacrylamide or agarose gel electrophoresis, metabolically labeled vWF was found to have incorporated (35S)-sulfate into all secreted multimer species. The time course of incorporation shows that sulfation occurs late in the biosynthesis of vWF, near the point at which multimerization occurs. Quantitative analysis suggests the presence, on average, of one molecule of sulfate per mature vWF subunit. Virtually all the detectable sulfate is released from the mature vWF subunit by treatment with endoglycosidases that remove asparagine-linked carbohydrates. Sulfated carbohydrate was localized first to the N-terminal half of the mature subunit (amino acids 1 through 1,365) by partial proteolytic digestion with protease V8; and subsequently to a smaller fragment within this region (amino acids 273 through 511) by sequential digestions with protease V8 and trypsin. Thus, the carbohydrate at asparagine 384 and/or 468 appears to be the site of sulfate modification. Sodium chlorate, an inhibitor of adenosine triphosphate-sulfurylase, blocks sulfation of vWF without affecting either the ability of vWF to assemble into high molecular weight multimers or the ability of vWF multimers to enter Weible-Palade bodies. The stability of vWF multimers in the presence of an endothelial cell monolayer also was unaffected by the sulfation state. Additionally, we have found that the cleaved propeptide of vWF is sulfated on asparagine-linked carbohydrate.

  5. Liouville-von Neumann molecular dynamics

    NASA Astrophysics Data System (ADS)

    Jakowski, Jacek; Morokuma, Keiji

    2009-06-01

    We present a novel first principles molecular dynamics scheme, called Liouville-von Neumann molecular dynamics, based on Liouville-von Neumann equation for density matrices propagation and Magnus expansion of the time-evolution operator. The scheme combines formally accurate quantum propagation of electrons represented via density matrices and a classical propagation of nuclei. The method requires a few iterations per each time step where the Fock operator is formed and von Neumann equation is integrated. The algorithm (a) is free of constraint and fictitious parameters, (b) avoids diagonalization of the Fock operator, and (c) can be used in the case of fractional occupation as in metallic systems. The algorithm is very stable, and has a very good conservation of energy even in cases when a good quality conventional Born-Oppenheimer molecular dynamics trajectories is difficult to obtain. Test simulations include initial phase of fullerene formation from gaseous C2 and retinal system.

  6. State of the art: von Willebrand disease.

    PubMed

    James, A H; Eikenboom, J; Federici, A B

    2016-07-01

    The State of the Art in von Willebrand disease (VWD) has been impacted not only by discoveries in the field of haemostasis, but also by changes in practice in other fields. The development of bleeding assessment tools has led to the clarification of bleeding symptoms and phenotype in VWD. New discoveries in the biology and genetics of von Willebrand factor (VWF) are challenging our existing diagnostics and classification(s). An improved understanding of reproductive physiology and the pathology of VWD along with changing obstetric, gynaecologic and haemostatic therapies necessitate an evolving response to the care of women with VWD. The survival of patients with autoimmune disease, malignancies and congenital heart disease along with increasing use of circulatory support devices and extracorporeal membrane oxygenation is increasing the prevalence of acquired von Willebrand syndrome. In each of these challenges, there are opportunities to improve the care of our patients with VWD.

  7. Treatment of the acquired von Willebrand syndrome.

    PubMed

    Budde, Ulrich; Scheppenheim, Sonja; Dittmer, Rita

    2015-12-01

    Acquired von Willebrand syndrome (aVWS) accounts for 22% of patients with abnormal von Willebrand factor. Most patients with known pathophysiological mechanisms suffer from cardiovascular, myeloproliferative and lymphoproliferative disorders. Less frequent associations are of autoimmune origin, due to hyperfibrinolysis, adsorption to tumor cells, reduced synthesis and prolonged circulation. The mechanisms leading to aVWS is hitherto not known in patients with liver and kidney diseases, drug use, glycogen storage disease, virus infections and at least 18 other disease entities. Diagnosis is complicated by the battery of tests needed, and their inherent rather low sensitivity and specificity for aVWS. Thus, even in acute bleeding situations it may take days until a firm diagnosis is settled and specific therapies can be initiated. The main aim is to shed more light onto this, compared with inherited von Willebrand disease, rare disease which affects at least 2-3% of the older population.

  8. [Carl Gillmeister: the first Doctor of veterinary medicine in Mecklenburg--and in Germany (1834)].

    PubMed

    Kuhlmann, W; Schäffer, J

    2004-02-01

    German schools and faculties of veterinary medicine did not receive the sovereign right to award the degree "Doctor medicinae veterinarae" until the early twentieth century. Until then, in the nineteenth century there were two possibilities for veterinarians to earn a doctoral degree, usually referred to as the title of "Doctor": 1. On the basis of an exceptionally excellent dissertation and after very stringent examination a candidate could be awarded the degree "Dr. med." by the faculty of a medical school, or, if the candidate had studied at a philosophical faculty, the degree "Dr. phil." 2. A doctoral degree specifically in veterinary medicine could be earned only at a medical faculty. The Medical Faculty of the University of Giessen awarded the degree "Doctor in arte veterinaria" for the first time in 1832. In this study we prove that Giessen was not the first German university to award a doctorate in veterinary medicine, a priority which has never been questioned in the literature. As early as 1829, veterinarians could earn the degree "Doctor artis veterinariae" at the Medical Faculty of the University of Rostock, where three such awards are documented between 1829 and 1831. The designation "medicina" was also intially avoided in Rostock. Therefore, of particular significance is the discovery of a fourth such document from the Rostock University Archives, the doctoral diploma of Carl Jacob Friedrich Gillmeister, who at the age of 22 was awarded the degree "Doctor medicinae veterinariae" in Rostock after a successful defense. This is the earliest, but also the last archival record of the German doctoral degree in veterinary medicine in the modern sense, because after Gillmeister no veterinarian could earn a doctoral degree in Rostock further more. Gillmeisters vita sheds light on the times and the difficulties of the veterinary profession in the poor agricultural area of Mecklenburg.

  9. Biosynthesis, processing and secretion of von Willebrand factor: biological implications.

    PubMed

    de Wit, T R; van Mourik, J A

    2001-06-01

    von Willebrand factor is a multimeric plasma glycoprotein that is required for normal haemostasis. von Willebrand factor is synthesized by endothelial cells and megakaryocytes, and originates from its precursor pro-von Willebrand factor. The endoproteolytic processing of pro-von Willebrand factor results in mature von Willebrand factor and von Willebrand factor propeptide (also known as von Willebrand Ag II). In endothelial cells, the propeptide controls the polymerization and subsequent targeting of von Willebrand factor to the storage vesicles, the so-called Weibel-Palade bodies. Upon stimulation of the endothelial cells, the Weibel-Palade bodies are translocated to the plasma membrane of the cell, and mature von Willebrand factor and its propeptide are co-secreted. After release, these polypeptides have divergent fates and serve different biological functions. Mature von Willebrand factor both controls platelet adhesion and aggregation at sites of vascular injury and acts as a chaperone protein for coagulation factor VIII. The von Willebrand factor propeptide may serve a role in modulating inflammatory processes. This still growing body of information indicates that the biological function of the von Willebrand factor gene product is more diverse than was previously thought.

  10. [Research advance in von Willebrand factor].

    PubMed

    Li, Xue-Mei; Jiang, Miao; Zhao, Yi-Ming

    2013-06-01

    von Willebrand factor (vWF) is a multimeric glycoprotein exclusively synthesized in endothelial cells and megakaryocytes. It plays important roles in the primary and secondary haemostasis. Deficiency or dysfunction of vWF may cause von Willebrand disease (vWD), and overexpression of vWF may cause thrombosis. Making an intensive study on vWF will help us to understand the pathophysiology, diagnosis and treatment of vWF-related diseases, such as vWD, TTP, venous thrombosis, stroke, and so on. In this article, the regulation of vWF activity and its relation with diseases mentioned above are reviewed.

  11. Mittelwert- und Arbeitstaktsynchrone Simulation von Dieselmotoren

    NASA Astrophysics Data System (ADS)

    Zahn, Sebastian

    Getrieben durch die immer restriktiveren Anforderungen an das Emissions- und Verbrauchsverhalten moderner Verbrennungsmotoren steigt die Komplexität von Motormanagementsystemen mit jeder Modellgeneration an. Damit geht nicht nur eine Zunahme des Softwareumfangs von Steuergeräten sondern zugleich ein deutlicher Anstieg des Applikations-, Vermessungs- und Testaufwandes einher. Zur Effizienzsteigerung des Software- und Funktionsentwicklungsprozesses haben sich daher in der Automobilindustrie sowie in Forschungsinstituten verschiedene modell- und simulationsbasierte Methoden wie die Model-in-the-Loop (MiL) Simulation, die Software-in-the-Loop (SiL) Simulation, das Rapid Control Prototyping (RCP) sowie die Hardware-in-the-Loop (HiL) Simulation etabliert.

  12. Level-Set-Segmentierung von Rattenhirn MRTs

    NASA Astrophysics Data System (ADS)

    Eiben, Björn; Kunz, Dietmar; Pietrzyk, Uwe; Palm, Christoph

    In dieser Arbeit wird die Segmentierung von Gehirngewebe aus Kopfaufnahmen von Ratten mittels Level-Set-Methoden vorgeschlagen. Dazu wird ein zweidimensionaler, kontrastbasierter Ansatz zu einem dreidimensionalen, lokal an die Bildintensität adaptierten Segmentierer erweitert. Es wird gezeigt, dass mit diesem echten 3D-Ansatz die lokalen Bildstrukturen besser berücksichtigt werden können. Insbesondere Magnet-Resonanz-Tomographien (MRTs) mit globalen Helligkeitsgradienten, beispielsweise bedingt durch Oberfiächenspulen, können auf diese Weise zuverlässiger und ohne weitere Vorverarbeitungsschritte segmentiert werden. Die Leistungsfähigkeit des Algorithmus wird experimentell an Hand dreier Rattenhirn-MRTs demonstriert.

  13. Laboratory diagnosis of von Willebrand disease.

    PubMed

    Roberts, J C; Flood, V H

    2015-05-01

    Von Willebrand disease (VWD) is considered the most common inherited bleeding disorder and may also be the most difficult to diagnose. Clinical symptoms of VWD include predominantly mild mucosal bleeding; surgical bleeding may occur with specific challenges and joint bleeding can occur in the most severe forms. A family history either of diagnosed VWD or of bleeding symptoms is typically present. Laboratory diagnosis requires a series of assays of von Willebrand factor (VWF) quantity and function, and factor VIII activity, with no single straightforward diagnostic test available to either confirm or exclude the diagnosis. Newer assays of VWF function are becoming more available and useful in determining the laboratory diagnosis of VWD.

  14. [Sigmund Freud, Rudolf Meringer and Carl Mayer: slips of the tongue and mis-readings. The history of a controversy].

    PubMed

    Hinterhuber, Hartmann

    2007-01-01

    In both his The Psychopathology of Everyday Life and his Lectures Sigmund Freud derived the terms unconscious, preconscious and conscious, particularly from slips in speech, slips in reading and forgetfulness. In these slips, Freud recognised parallels to dreams. In the work mentioned, he analysed these in depth as part of mental motivation. In the papers referred to, Sigmund Freud paid tribute to Rudolf Meringer and Carl Mayer's study which was published in 1895. Meringer and Mayer showed as phenomena reversals and rearrangement of whole words, syllables or sounds, along with pre-tones or anticipations and echoes, word contaminations and word substitutions as responsible for slips of the tongue. The present work demonstrates how passionately these three scientists have contributed to the controversy of their standpoints. For modern psycholinguistics and the psychology of language, speech errors are always an expression of a momentary malfunction of the human speech production system: for the cognitive process of speech production slips of the tongue offer an insight into speech processing. Pre-tones and echoes, serialization errors, as Meringer and Mayer recognised, represent the vast majority of slips of the tongue. They do not reveal any hidden point. But with lexical-semantic slips of the tongue the question of mental motivation is admissible. This short paper is a sign of appreciation and gratitude: firstly, a modest birthday gift for Sigmund Freud, secondly homage to Carl Mayer, who influenced generations of neurologists in his 40 years of chairing the Psychiatric-Neurological Clinic in Innsbruck, so that Hans Ganner rightly spoke of a "Carl Mayer School". But lastly, this short study is also-and especially-a late recognition of Rudolf Meringer, the great Austrian linguist. The view an individual has concerning mental processes and the "topology of the psychic apparatus" is decisive as to the power of determination attached to the unconscious.

  15. Otto Rank, the Rankian circle in Philadelphia, and the origins of Carl Rogers' person-centered psychotherapy.

    PubMed

    deCarvalho, R J

    1999-05-01

    Otto Rank's will therapy helped shape the ideas and techniques of relationship therapy developed by the Philadelphia social workers Jessie Taft, Virginia Robinson, and Frederick Allen in the 1930s. Rank's work and these ideas and techniques in turn strongly influenced the formulation of Carl Rogers' person-centered psychotherapy. This article compares and contrasts will, relationship, and person-centered approaches to psychotherapy and discusses the social factors--primarily the professional conflicts between a male-dominated psychiatry and female social workers over the independent practice of psychotherapy--that were crucial in the dissemination of Rank's psychological thought and the early popularity of Rogers.

  16. "The most important technique …": Carl Rogers, Hawthorne, and the rise and fall of nondirective interviewing in sociology.

    PubMed

    Lee, Raymond M

    2011-01-01

    In the 1940s, interviewing practice in sociology became decisively influenced by techniques that had originally been developed by researchers in other disciplines working within a number of therapeutic or quasi-therapeutic contexts, in particular the "nondirective interviewing" methods developed by Carl Rogers and the interviewing procedures developed during the Hawthorne studies. This article discusses the development of nondirective interviewing and looks at how in the 1930s and '40s the approach came to be used in sociology. It examines the factors leading to both the popularity of the method and its subsequent fall from favor.

  17. [The Costantin Von Economo's lethargic encefalitis

    PubMed

    Pistacchio, E.

    1998-01-01

    Starting from the Constantin Von Economo's description of a "new" disease, the lethargic encephalitis, the author delineates the history of an infectious sleeping sickness that caused epidemics in Europe from 1917 to 1928 and led to create, in Italy, the "Institutes for Encephalitis".

  18. Dr. von Braun Visits Huntsville Boys Club

    NASA Technical Reports Server (NTRS)

    1961-01-01

    Dr. von Braun, Director of Marshall Space Flight Center (MSFC) and chairman of this year's United Givers Fund (UGF) drive at MSFC, takes time out from the problems of sending a man to the Moon to talk baseball with 11-year-old Randy Smith at the Huntsville Boys Club.

  19. Dr. von Braun Discusses 'Bottle Suit' Concept

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a 'bottle suit' model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled 'Man in Space.'

  20. A note on derivations of Murray–von Neumann algebras

    PubMed Central

    Kadison, Richard V.; Liu, Zhe

    2014-01-01

    A Murray–von Neumann algebra is the algebra of operators affiliated with a finite von Neumann algebra. In this article, we first present a brief introduction to the theory of derivations of operator algebras from both the physical and mathematical points of view. We then describe our recent work on derivations of Murray–von Neumann algebras. We show that the “extended derivations” of a Murray–von Neumann algebra, those that map the associated finite von Neumann algebra into itself, are inner. In particular, we prove that the only derivation that maps a Murray–von Neumann algebra associated with a factor of type II1 into that factor is 0. Those results are extensions of Singer’s seminal result answering a question of Kaplansky, as applied to von Neumann algebras: The algebra may be noncommutative and may even contain unbounded elements. PMID:24469831

  1. (Never) Mind your p's and q's: Von Neumann versus Jordan on the foundations of quantum theory

    NASA Astrophysics Data System (ADS)

    Duncan, A.; Janssen, M.

    2013-03-01

    In 1927, in two papers entitled "On a new foundation [Neue Begründung] of quantum mechanics," Pascual Jordan presented his version of what came to be known as the Dirac-Jordan statistical transformation theory. Jordan and Paul Dirac arrived at essentially the same theory independently of one another at around the same time. Later in 1927, partly in response to Jordan and Dirac and avoiding the mathematical difficulties facing their approach, John von Neumann developed the modern Hilbert space formalism of quantum mechanics. We focus on Jordan and von Neumann. Central to the formalisms of both are expressions for conditional probabilities of finding some value for one quantity given the value of another. Beyond that Jordan and von Neumann had very different views about the appropriate formulation of problems in quantum mechanics. For Jordan, unable to let go of the analogy to classical mechanics, the solution of such problems required the identification of sets of canonically conjugate variables, i.e., p's and q's. For von Neumann, not constrained by the analogy to classical mechanics, it required only the identification of a maximal set of commuting operators with simultaneous eigenstates. He had no need for p's and q's. Jordan and von Neumann also stated the characteristic new rules for probabilities in quantum mechanics somewhat differently. Jordan and Dirac were the first to state those rules in full generality. Von Neumann rephrased them and, in a paper published a few months later, sought to derive them from more basic considerations. In this paper we reconstruct the central arguments of these 1927 papers by Jordan and von Neumann and of a paper on Jordan's approach by Hilbert, von Neumann, and Nordheim. We highlight those elements in these papers that bring out the gradual loosening of the ties between the new quantum formalism and classical mechanics. This paper was written as part of a joint project in the history of quantum physics of the Max Planck

  2. Physical Realization of von Neumann Lattices in Rotating Bose Gases with Dipole Interatomic Interactions

    PubMed Central

    Cheng, Szu-Cheng; Jheng, Shih-Da

    2016-01-01

    This paper reports a novel type of vortex lattice, referred to as a bubble crystal, which was discovered in rapidly rotating Bose gases with long-range interactions. Bubble crystals differ from vortex lattices which possess a single quantum flux per unit cell, while atoms in bubble crystals are clustered periodically and surrounded by vortices. No existing model is able to describe the vortex structure of bubble crystals; however, we identified a mathematical lattice, which is a subset of coherent states and exists periodically in the physical space. This lattice is called a von Neumann lattice, and when it possesses a single vortex per unit cell, it presents the same geometrical structure as an Abrikosov lattice. In this report, we extend the von Neumann lattice to one with an integral number of flux quanta per unit cell and demonstrate that von Neumann lattices well reproduce the translational properties of bubble crystals. Numerical simulations confirm that, as a generalized vortex, a von Neumann lattice can be physically realized using vortex lattices in rapidly rotating Bose gases with dipole interatomic interactions. PMID:27545446

  3. A double commutant theorem for Murray-von Neumann algebras.

    PubMed

    Liu, Zhe

    2012-05-15

    Murray-von Neumann algebras are algebras of operators affiliated with finite von Neumann algebras. In this article, we study commutativity and affiliation of self-adjoint operators (possibly unbounded). We show that a maximal abelian self-adjoint subalgebra A of the Murray-von Neumann algebra A(f)(R) associated with a finite von Neumann algebra R is the Murray-von Neumann algebra A(f)(A(0)), where A(0) is a maximal abelian self-adjoint subalgebra of R and, in addition, A(0) is A Π R. We also prove that the Murray-von Neumann algebra A(f)(C) with C the center of R is the center of the Murray-von Neumann algebra A(f)(R). Von Neumann's celebrated double commutant theorem characterizes von Neumann algebras R as those for which R'' = R, where R', the commutant of R, is the set of bounded operators on the Hilbert space that commute with all operators in R. At the end of this article, we present a double commutant theorem for Murray-von Neumann algebras.

  4. [Molecular biology of von Willebrand disease].

    PubMed

    Melo-Nava, Brenda; Peñaloza, Rosenda

    2007-01-01

    Von Willebrand Factor (VWF) is a large multimeric glycoprotein expressed in the megakaryocytes and endothelial cells of all vertebrates. It participates fundamentally in the primary and secondary hemostasis because it induces the adhesion of platelets to vascular subendothelium and promotes aggregation of platelets when blood vessels and capillaries are damaged. In addition, VWF links to factor VIII which avoids its proteolysis. The deficiency or the inadequate synthesis of the VWF causes von Willebrand disease (VWD), which is the most common hereditary bleeding disorder in humans principally from mucous and cutaneous sites. VWD is difficult to detect with accuracy due to interrelation among VWF with different components of hemostasis, although it is performed by different tests of haemostatic system, and the basic mechanisms in VWD are herein emphasized. The diagnosis of VWD is difficult due to the heterogeneous manifestation of the disease, which also complicates its classification. This article focuses on the molecular aspects of the disease and discusses their possible clinical implications.

  5. Vascular Manifestations of von Recklinghausen's Disease

    PubMed Central

    Fye, Kenneth H.; Jacobs, Richard P.; Roe, Robert L.

    1975-01-01

    A casual relationship between von Recklinghausen's disease, or neurofibromatosis, and arteriolar abnormalities has been reported in the European literature. A patient was seen who had biopsy-proved neurofibromatosis and renovascular hypertension and retroperitoneal bleeding. An arteriographic study showed multiple small aneurysms throughout the coeliac axis, the superior mesenteric artery and in several small intrarenal vessels. Renal vein renin levels were elevated particularly in the right renal vein, supporting the diagnosis of renovascular hypertension. Both the aneurysms seen in angiographic studies and the retroperitoneal hemorrhage are probably vascular manifestations of von Recklinghausen's disease. Support for this conclusion is enhanced by the absence of clinical, laboratory or histologic data supporting the only tenable differential diagnosis, periarteritis nodosa. ImagesFigure 1.Figure 2.Figure 3.Figure 4. PMID:803743

  6. Herstellung von Chitosan und einige Anwendungen

    NASA Astrophysics Data System (ADS)

    Struszczyk, Marcin Henryk

    2001-05-01

    1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

  7. Verbesserung der Symmetrie von Hirnaufnahmen entlang der Sagittalebene

    NASA Astrophysics Data System (ADS)

    Ens, Konstantin; Wenzel, Fabian; Fischer, Bernd

    Die lokale Symmetrie von Hirnscans entlang der Sagittalebene zu ermitteln und zu modizifieren, ist für eine Reihe neurologischer Anwendungen interessant. Beispielsweise kann der voxelweise Vergleich von rechter und linker Hirnhälfte nur dann Aufschluss über die Lokalisierung von Läsionen geben, wenn durch Transformation ein Hirnscan eine möglichst hohe Symmetrie aufweist. Ein weiteres Anwendungsgebiet ist die Visualisierung von medialen Hirnschnitten, für die die Trennfläche beider Hirnhälfte möglichst eben sein sollte. Diese Arbeit stellt die Entwicklung eines Verfahrens vor, mit dessen Hilfe die Symmetrie von Hirnaufnahmen entlang der Sagittalebene verbessert werden kann. Dies geschieht unter Verwendung von aktiven Konturen, die mit Hilfe einer neuartigen Kostenfunktion gesteuert werden. Experimente am Ende der Arbeit mit strukturellen Kernspinaufnahmen demonstrieren die Leistungsfähigkeit des Verfahrens.

  8. 1993-94 Annual Performance Report for the Carl D. Perkins Vocational and Applied Technology Education Act of 1990. Postsecondary Institutions.

    ERIC Educational Resources Information Center

    Wisconsin State Board of Vocational, Technical and Adult Education, Madison. Wisconsin Technical Coll. System.

    During the 1993-94 program year, the 16 local Wisconsin Technical College System (WTCS) postsecondary districts delivered a total of 98,191 services to 36,071 clients through grant activities funded by the Carl D. Perkins Act. The WTCs board developed a format and process for reporting performance measures. All 16 WTCS districts exceeded the 35%…

  9. Carl D. Perkins Vocational and Technical Education Act of 1998. Report to Congress on State Performance, Program Year 2004-05

    ERIC Educational Resources Information Center

    US Department of Education, 2007

    2007-01-01

    The "Carl D. Perkins Vocational and Technical Education Act of 1998" requires that the Secretary provide the appropriate committees of Congress copies of annual reports received by the department from each eligible agency that receives funds under the Act. Congress has made "accountability for results" a central focus of the…

  10. Carl D. Perkins Vocational and Technical Education Act of 1998. Report to Congress on State Performance, Program Year 2005-06

    ERIC Educational Resources Information Center

    Office of Vocational and Adult Education, US Department of Education, 2008

    2008-01-01

    The "Carl D. Perkins Vocational and Technical Education Act of 1998" (commonly referred to as "Perkins," "Perkins III," or "the Act" and referred to hereafter as Perkins III) requires, in Sec. 113(c)(3)(C), that the secretary provide the appropriate committees of Congress copies of annual reports received by…

  11. The 1994-96 Two-Year Plan for the Use of Federal Funds Available under the Carl D. Perkins Vocational and Applied Technology Education Act.

    ERIC Educational Resources Information Center

    Wisconsin Technical Coll. System Board, Madison.

    The stated purpose of the Carl D. Perkins Vocational, Technical, and Applied Technology Act is to make the United States more competitive in the world economy by developing more fully the academic and occupational skills of all segments of the population. The Wisconsin Department of Public Instruction (DPI) proposes to achieve this purpose by…

  12. Revising Department of Public Instruction Practices Regarding the Carl Perkins Vocational Education Act. A Workshop Report with Recommendations for Improvement. Bulletin No. 95168.

    ERIC Educational Resources Information Center

    Wisconsin State Dept. of Public Instruction, Madison.

    This report describes the process, participants, and recommendations for change evolving from a workshop centered on a review of Wisconsin Department of Public Instruction (DPI) practices relating to the federal Carl Perkins Act. A workshop summary discusses the background, process, and outcomes of the workshop. Highlights are provided from the…

  13. The 1991-94 Three Year Plan for the Use of Federal Funds Available under the Carl D. Perkins Vocational and Applied Technology Education Act.

    ERIC Educational Resources Information Center

    Wisconsin State Board of Vocational, Technical, and Adult Education, Madison.

    This 1991-94 3-year plan describes proposed use of federal funds available to Wisconsin for the support of vocational and technical education. The first three sections provide an introduction, state board certification, and the table of contents. Section IV describes assessment provisions of the Carl D. Perkins Vocational and Applied Technology…

  14. Portrait of Dr. Von Braun with Walt Disney, 1954.

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  15. PT2385 for the Treatment of Von Hippel-Lindau Disease-Associated Clear Cell Renal Cell Carcinoma

    ClinicalTrials.gov

    2017-04-04

    VHL Gene Mutation; VHL; VHL Syndrome; VHL Gene Inactivation; Von Hippel; Von Hippel-Lindau Disease; Von Hippel's Disease; Von Hippel-Lindau Syndrome, Modifiers of; Clear Cell Renal Cell Carcinoma; Clear Cell RCC; ccRCC

  16. Testing aspects of Carl Rogers's theory of creative environments: child-rearing antecedents of creative potential in young adolescents.

    PubMed

    Harrington, D M; Block, J H; Block, J

    1987-04-01

    Longitudinal data involving 106 children and their parents were used to test preschool child-rearing implications of Carl Rogers's theory of creativity-fostering environments (Rogers, 1954). Indices were developed for each parent and for each mother-father combination that reflected the degree to which the parents' child-rearing practices and interactions with their preschool children matched the recommendations implicit in Rogers's description of a creativity-fostering environment. The three indices of Rogers-prescribed child-rearing practices each correlated positively (rs = .38 to .46) and significantly (all ps less than .001) with a composite index of creative potential in early adolescence, 7 to 11 years later. Rogers-prescribed preschool child-rearing practices also emerged as significant antecedents of adolescent creative potential in regression/path analyses that held constant the influence of sex, preschool intelligence, and preschool creative potential. Theoretical and methodological aspects of the study are discussed.

  17. Modifications of the isolated frog heart preparation in Carl Ludwig's Leipzig Physiological Institute: relevance for cardiovascular research.

    PubMed

    Zimmer, H G

    2000-01-01

    Carl Ludwig was the first physiologist to systematically study isolated organs (heart, muscle, kidney, liver, lung). In his Leipzig Physiological Institute, the isolated perfused frog heart preparation was established in 1866 by Elias Cyon. This preparation was subsequently subjected to various modifications, and many important observations were made by scientists such as Joseph Coats, Henry Pickering Bowditch, Luigi Luciani, Michael Joseph Rossbach, Hugo Kronecker and Otto Frank. The influence of filling pressure on contraction amplitude, the all-or-none law of the heart, the absolute refractory period, postextrasystolic potentiation, the staircase ('Treppe') phenomenon and the dependence of heart function on oxidative metabolism were discovered. The negative chronotropic and inotropic effects of vagus nerve stimulation were also first documented, and a model to induce arrhythmias was established. The isolated frog heart preparation became a widely used standard model for teaching and for basic cardiovascular research. Sidney Ringer discovered the essential role of calcium ions for heart function. Otto Loewi discovered the chemical transduction mechanism of the vagus with acetylcholine as transmitter. In more recent times, the cyclical changes in cAMP and cGMP that occur during the cardiac cycle were first described in the frog heart by Wollenberger and associates. Thus, the isolated perfused frog heart established and modified in Carl Ludwig's Leipzig Physiological Institute led not only to the discovery of basic phenomena, but also to observations that became the basis for concepts to be developed and elaborated later. Furthermore, the isolated perfused frog heart was the starting point for the development of the isolated mammalian heart in the retrogradely perfused, nonworking mode in the heart-lung modification and in the working heart preparation.

  18. Approximating incompatible von Neumann measurements simultaneously

    SciTech Connect

    Heinosaari, Teiko; Jivulescu, Maria Anastasia; Reitzner, Daniel; Ziman, Mario

    2010-09-15

    We study the problem of performing orthogonal qubit measurements simultaneously. Since these measurements are incompatible, one has to accept additional imprecision. An optimal joint measurement is the one with the least possible imprecision. All earlier considerations of this problem have concerned only joint measurability of observables, while in this work we also take into account conditional state transformations (i.e., instruments). We characterize the optimal joint instrument for two orthogonal von Neumann instruments as being the Lueders instrument of the optimal joint observable.

  19. [Albrecht von Haller. An illustrious ancestor].

    PubMed

    Peiper, H-J

    2008-05-01

    Albrecht von Haller (1708-1777) was one of the most famous and important men of the eighteenth century. His achievements make him comparable with Lessing and Newton. In Blumenbach's opinion he was one of the enlightenment's greatest thinkers in both versatility and depth. He contributed significantly to developments in medicine, physiology, botany, pharmacology, theology, literature, editing, chronicles, biography, geography, and during his later years in Switzerland jurisprudence and agrarian reform. On the occasion of the 300th anniversary of his birth, important scientific landmarks in his life are described, with special attention to his achievements in the fields of anatomy, physiology, surgery, and experimental research.

  20. Acquired von Willebrand syndrome: von Willebrand factor propeptide to von Willebrand factor antigen ratio predicts remission status

    PubMed Central

    Lee, Adrienne; Sinclair, Gary; Valentine, Karen; James, Paula

    2014-01-01

    We investigated a case of acquired von Willebrand syndrome (AVWS) secondary to a nonneutralizing anti-von Willebrand factor (VWF) antibody associated with an autoimmune disorder. At diagnosis, VWF activity (VWF:Act), antigen (VWF:Ag), multimers, and factor VIII coagulant activity were virtually absent. VWF propeptide (VWFpp) was elevated with an infinitely high VWFpp to VWF:Ag ratio (VWFpp:Ag) consistent with rapid VWF clearance. Immunosuppressive treatment resulted in phenotypic remission 1 with normalization of VWF/factor VIII levels and multimer pattern. However, VWFpp:Ag remained elevated (∼2× normal), consistent with ongoing VWF clearance by the remaining anti-VWF antibody still present by enzyme-linked immunosorbent assay. This suggests that increased VWF secretion was compensating for the incomplete remission state. Relapse occurred when VWFpp:Ag was again infinitely high, with associated decreased VWFpp but unchanged anti-VWF titers; switching the balance to favor VWF clearance over secretion. Complete remission with undetectable anti-VWF occurred only when VWFpp:Ag was normal. This case of relapsing-remitting AVWS demonstrates the use of VWFpp:Ag for predicting remission status. PMID:24951428

  1. Virtualized Optical Network (VON) for Future Internet and Applications

    NASA Astrophysics Data System (ADS)

    Jinno, Masahiko; Tsukishima, Yukio; Takara, Hidehiko; Kozicki, Bartlomiej; Sone, Yoshiaki; Sakano, Toshikazu

    A virtualized optical network (VON) is proposed as a key to implementing increased agility and flexibility into the future Internet and applications by providing any-to-any connectivity with the appropriate optical bandwidth at the appropriate time. The VON is enabled by introducing optical transparentization and optical fine granular grooming based on optical orthogonal frequency division multiplexing.

  2. Rare liver tumor: symptomatic giant von Meyenburg complex

    PubMed Central

    Singh, Yardesh; Cawich, Shamir O.; Ramjit, Chunilal; Naraynsingh, Vijay

    2016-01-01

    von Meyenburg complexes are hamartomas that arise from intra-hepatic bile ducts. Symptomatic lesions are uncommon and giant lesions are exceedingly rare. When encountered, they should be excised because there are reports of malignant change in large, symptomatic lesions. We report a case of a symptomatic giant von Meyenburg complex. PMID:28068648

  3. Victor or Villain? Wernher von Braun and the Space Race

    ERIC Educational Resources Information Center

    O'Brien, Jason L.; Sears, Christine E.

    2011-01-01

    Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

  4. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Marshall Space Flight Center (MSFC) Director, Dr. von Braun, submerges after spending some time under water in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  5. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Astronaut L. Gordon Cooper checks the neck ring of a space suit worn by Marshall Space Flight Center (MSFC) Director, Dr. von Braun before he submerges into the water of the MSFC Neutral Buoyancy Simulator (NBS). Wearing a pressurized suit and weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  6. Dr. von Braun Tries Out the Neutral Buoyancy Simulator (NBS)

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Marshall Space Flight Center (MSFC) Director, Dr. von Braun, is shown leaving the suiting-up van wearing a pressure suit prepared for a tryout in the MSFC Neutral Buoyancy Simulator (NBS). Weighted to a neutrally buoyant condition, Dr. von Braun was able to perform tasks underwater which simulated weightless conditions found in space.

  7. Wernher von Braun and Saturn IB on Launch Pad

    NASA Technical Reports Server (NTRS)

    1968-01-01

    Dr. Wernher von Braun stands in front of a Saturn IB launch vehicle at Kennedy Space Flight Center. Dr. von Braun led a team of German rocket scientists, called the Rocket Team, to the United States, first to Fort Bliss/White Sands, later being transferred to the Army Ballistic Missile Agency at Redstone Arsenal in Huntsville, Alabama. They were further transferred to the newly established NASA/Marshall Space Flight Center (MSFC) in Huntsville, Alabama in 1960, and Dr. von Braun became the first Center Director. Under von Braun's direction, MSFC developed the Mercury-Redstone, which put the first American in space; and later the Saturn rockets, Saturn I, Saturn IB, and Saturn V. The Saturn V launch vehicle put the first human on the surface of the Moon, and a modified Saturn V vehicle placed Skylab, the first United States' experimental space station, into Earth orbit. Dr. von Braun was MSFC Director from July 1960 to February 1970.

  8. Molecular diagnosis of von Willebrand disease.

    PubMed

    Baronciani, L; Goodeve, A; Peyvandi, F

    2017-03-01

    The role of molecular characterization in the diagnosis of von Willebrand disease (VWD) is not essential if the patients have been extensively investigated using phenotypic analysis. On the other hand, if some of these phenotype assays are not available, the identification of the mutation causing the disease could be crucial for an accurate diagnosis. Nevertheless, there are several reasons for performing molecular analysis in patients phenotypically well characterized, e.g. to identify the mutation causing VWD can be useful for patients and their family members when prenatal diagnosis is required (type 3 or severe type 2). In this manuscript, we report the techniques used for the molecular characterization of suspected VWD patients. We describe the use of online von Willebrand factor database and online single nucleotide variation databases, the former to verify whether a candidate mutation has been previously identified in other VWD patients and the latter to ascertain whether a putative mutation has been reported earlier in healthy individuals. We listed the available in silico analysis tools, to determine the predicted pathogenicity of a sequence variant and to establish its possible negative effect on the normal splicing process. We also report the strategy that can be used to identify VWD type 2 patients' mutations in subjects who have been fully characterized using the phenotype assays.

  9. Carl Liebermeister (1833-1901): a pioneer of the investigation and treatment of fever and the developer of a statistical test.

    PubMed

    Seneta, Eugene; Seif, Fritz J; Liebermeister, Hermann; Dietz, Klaus

    2004-11-01

    In the second half of the nineteenth century, when the typical course of various febrile clinical phenomena was found to be specific to particular infectious diseases, Carl Liebermeister successfully pioneered the investigation of the patho physiology of fever and the regulation of body temperature. He applied biophysical and pharmacological antipyresis, especially for the treatment of typhoid fever, and developed new statistical tools for the evaluation of therapeutic results.

  10. The Military Decision Making Process: Making Better Decisions Versus Making Decisions Better

    DTIC Science & Technology

    2007-11-02

    Background to Decision Making, 103. (No reference listed). 69 SELECTED BIBLIOGRAPHY BOOKS Bertalanffy , Ludwig von . General Systems Theory...Washington, D.C.: Headquarters, Department of the Army), 1993, 6-3. 30 Carl Von Clausewitz, On War, ed. and trans by Michael Howard and Peter Paret...Field Marshal Helmuth von Moltke’s famous dictum that “no plan survives contact with the enemy.”2 Current keystone doctrine establishes flexibility

  11. Creating von Laue patterns in crystal scattering with partially coherent sources

    NASA Astrophysics Data System (ADS)

    Wang, Yangyundou; Kuebel, David; Visser, Taco D.; Wolf, Emil

    2016-09-01

    When spatially coherent radiation is diffracted by a crystalline object, the field is scattered in specific directions, giving rise to so-called von Laue patterns. We examine the role of spatial coherence in this process. Using the first-order Born approximation, a general analytic expression for the far-zone spectral density of the scattered field is obtained. This equation relates the coherence properties of the source to the angular distribution of the scattered intensity. We apply this result to two types of sources. Quasihomogeneous Gaussian Schell-model sources are found to produce von Laue spots whose size is governed by the effective source width. Delta-correlated ring sources produce von Laue rings and ellipses instead of point-like spots. In forward scattering, polychromatic ellipses are created, whereas in backscattering striking, overlapping ring patterns are formed. We show that both the directionality and the wavelength-selectivity of the scattering process can be controlled by the state of coherence of the illuminating source.

  12. Two novel anti-von Willebrand factor monoclonal antibodies.

    PubMed

    Spadafora-Ferreira, M; Lopes, A A; Coelho, V; Guilherme, L; Kalil, J

    2000-01-15

    Von Willebrand Factor is a multimer produced by endothelial cells and megakaryocytes, being stored in intracellular organelles, such as the Weibel-Palade bodies and alpha-granules in endothelial cells and platelets, respectively. This molecule acts as a carrier protein for factor VIIIc, involved in the intrinsic pathway of blood coagulation maintaining its stability in circulation. Von Willebrand Factor also plays an important role in platelet aggregation and adhesion to injured vessel wall. It interacts with platelets through two distinct glycoproteins, GPIb and GPIIb/IIIa. We raised two monoclonal antibodies, ECA-3 and ECA-4, against human umbilical vascular endothelial cells that recognize and immunoprecipitate von Willebrand Factor. Interestingly, ECA-4 monoclonal antibody is able to completely inhibit platelet agglutination induced by ristocetin, suggesting that it binds to von Willebrand Factor close to platelet GPIb binding site. The use of monoclonal antibodies to identify von Willebrand Factor binding regions to factor VIII or platelets has been reported by others. In pulmonary hypertension, abnormalities have been detected on the multimeric structure of the molecule as well as on its proteolytic fragments, by using monoclonal antibodies. Moreover, monoclonal antibodies raised against specific regions of von Willebrand Factor molecule may allow studies of functional abnormalities of this protein in inherited and acquired disorders like subtypes of von Willebrand's disease.

  13. [Von Willebrand disease in the Netherlands: the WiN study].

    PubMed

    Sanders, Yvonne V; de Wee, Eva M; Meijer, Karina; Eikenboom, J; van der Bom, Jeroen G; Fijnvandraat, C J Karin; Laros-van Gorkom, Britta A P; Cnossen, Marjon H; Mauser-Bunschoten, Evelien P; Leebeek, Frank W G

    2014-01-01

    Von Willebrand disease is the most common inherited bleeding disorder and is characterised by mucocutaneous bleeding. Von Willebrand disease is caused by reduced levels or reduced function of von Willebrand factor. Depending on the cause, von Willebrand disease is distinguished into various types with their own characteristics and treatment options. The frequency and severity of bleeding in patients with von Willebrand disease is strongly determined by von Willebrand factor levels, factor VIII levels and the type of von Willebrand disease. Eighty-five percent of all adult females with von Willebrand disease reports menorrhagia. A high percentage have postpartum excessive blood loss (37% of all deliveries). The quality of life is reduced in patients with von Willebrand disease. Patients with von Willebrand disease have a reduced risk of arterial thrombosis such as a myocardial or cerebral infarction.

  14. Interactions of von Willebrand factor and ADAMTS13 in von Willebrand disease and thrombotic thrombocytopenic purpura.

    PubMed

    Budde, U; Schneppenheim, R

    2014-01-01

    The function of von Willebrand factor (VWF), a huge multimeric protein and a key factor in platelet dependent primary haemostasis, is regulated by its specific protease ADAMTS13. The ADAMTS13 dependent degradation of VWF to its proteolytic fragments can be visualized as a characteristic so-called triplet structure of individual VWF oligomers by multimer analysis. Lack of VWF high molecular weight multimers (VWF-HMWM) or their pathologically enhanced degradation underlies a particular type of von Willebrand disease, VWD type 2A with a significant bleeding tendency, and may also be observed in acquired von Willebrand syndrome due to cardiovascular disease. In these conditions multimer analysis is an obligatory and powerful tool for diagnosis of VWD. The opposite condition, the persistence of ultralarge VWF (UL-VWF) multimers may cause the microangiopathic life-threatening disorder thrombotic thrombocytopenic purpura (TTP). During the course of active TTP, UL-VWF is consumed in the hyaline thrombi formed in the microvasculature which will ultimately result in the loss of UL-VWF and VWF-HMWM. Therefore, VWF multimer analysis is not a valid tool to diagnose TTP in the active phase of disease but may be helpful for the diagnosis of TTP patients in remission.

  15. Quantenphysik Interferometrie von C70-Molekülen

    NASA Astrophysics Data System (ADS)

    Ziegler, Thomas

    2002-05-01

    Interferenzversuche mit Neutronen und schweren Atomen stellen kein großes Problem mehr dar, selbst die Welleneigenschaften von C60-und C70-Molekülen wurden bereits nachgewiesen. Allerdings stößt man bei der Realisation immer feinerer Gitter mit Gitterkonstanten von etwa 100 nm im Fall dieser Moleküle auf technische Probleme. Wissenschaftlern der Universität Wien ist es jüngst gelungen, ein so genanntes Talbot-Lau-Interferometer zu realisieren und die Welleneigenschaften von C70 mit einer bislang unerreichten Qualität nachzuweisen [1].

  16. Valence bond and von Neumann entanglement entropy in Heisenberg ladders.

    PubMed

    Kallin, Ann B; González, Iván; Hastings, Matthew B; Melko, Roger G

    2009-09-11

    We present a direct comparison of the recently proposed valence bond entanglement entropy and the von Neumann entanglement entropy on spin-1/2 Heisenberg systems using quantum Monte Carlo and density-matrix renormalization group simulations. For one-dimensional chains we show that the valence bond entropy can be either less or greater than the von Neumann entropy; hence, it cannot provide a bound on the latter. On ladder geometries, simulations with up to seven legs are sufficient to indicate that the von Neumann entropy in two dimensions obeys an area law, even though the valence bond entanglement entropy has a multiplicative logarithmic correction.

  17. Carl Gustav Jung, Quantum Physics and the Spiritual Mind: A Mystical Vision of the Twenty-First Century

    PubMed Central

    Valadas Ponte, Diogo; Schäfer, Lothar

    2013-01-01

    We describe similarities in the ontology of quantum physics and of Carl Gustav Jung’s psychology. In spite of the fact that physics and psychology are usually considered as unrelated, in the last century, both of these disciplines have led at the same time to revolutionary changes in the Western understanding of the cosmic order, discovering a non-empirical realm of the universe that doesn’t consist of material things but of forms. These forms are real, even though they are invisible, because they have the potential to appear in the empirical world and act in it. We present arguments that force us to believe, that the empirical world is an emanation out of a cosmic realm of potentiality, whose forms can appear as physical structures in the external world and as archetypal concepts in our mind. Accordingly, the evolution of life now appears no longer as a process of the adaptation of species to their environment, but as the adaptation of minds to increasingly complex forms that exist in the cosmic potentiality. The cosmic connection means that the human mind is a mystical mind. PMID:25379259

  18. Quality management of medical education at the Carl Gustav Carus Faculty of Medicine, University of Technology Dresden, Germany.

    PubMed

    Dieter, Peter Erich

    2008-12-01

    The Carl Gustav Carus Faculty of Medicine, University of Technology Dresden, Germany, was founded in 1993 after the reunification of Germany. In 1999, a reform process of medical education was started together with Harvard Medical International. The traditional teacher and discipline-centred curriculum was replaced by a student-centred, interdisciplinary and integrative curriculum which has been named DIPOL (Dresden Integrative Patient/Problem- Oriented Learning). The reform process was accompanied and supported by a parallel-ongoing Faculty Development Program. In 2004, a Quality Management Program in medical education was implemented, and in 2005 medical education received DIN EN ISO 9001:2000 certification. Quality Management Program and DIN EN ISO 9001:2000 certification were/are unique for the 34 medical schools in Germany. The students played a very important strategic role in all processes. They were/are members in all committees like the Faculty Board, the Board of Study Affairs (with equal representation) and the ongoing audits in the Quality Management Program. Students are the only ones who experience all years of the curriculum and are capable of detecting, for example gaps, overlaps, inconsistencies of the curriculum and assessments. Therefore, the in-depth knowledge of students about the medical school's curriculum is a very helpful and essential tool in curriculum reform processes and Quality Management Programs of medical education. The reform in medical education, the establishment of the Quality Management program and the certification resulted in an improvement of quality and output of medical education and medical research.

  19. Carl Friedrich Naumann and the introduction of enantio terminology: a review and analysis on the 150th anniversary.

    PubMed

    Gal, Joseph

    2007-02-01

    Enantiomorphism and enantiomorphous were the first enantio-based terms, introduced 150 years ago, by Carl Friedrich Naumann, a German crystallographer, to refer to non-superposable mirror-image crystals. The terminology was not adopted by Pasteur, the discoverer of molecular chirality, and was not embraced at first in the stereochemical context, until it was accepted in 1877 by Van't Hoff in the German edition of his proposal for the tetrahedral asymmetric carbon atom. In the 1890s the use of enantio terms began to spread in the research literature, and many new derivatives of Naumann's original two terms were subsequently introduced. Problems in the usage of some of the terms are often found in the literature, e.g., enantiomorphism is sometimes confused with chirality; enantiomeric is often misused; the meaning of some of the many derived terms, e.g., enantiosymmetric, enantioposition, etc., is unclear. All in all, Naumann should be remembered as the creator of essential terminology in the realm of chirality.

  20. The Swedish marine nematologist Carl Allgén (1886-1960): a bio-bibliography and his collection.

    PubMed

    Boström, Sven; Holovachov, Oleksandr

    2017-02-20

    The Swedish marine nematologist Carl Allgén (1886-1960) published 185 scientific papers on parasitic, terrestrial, limnic and especially marine nematodes between 1921 and 1960. Among them are also some papers on species of suctorians found mostly on desmodorid nematodes. He described about 70 new genera and over 800 new species and subspecies of nematodes. Allgén left a large collection of nematodes to the Swedish Museum of Natural History in Stockholm and it is now deposited in the invertebrate collection of the Zoology department. The collection comprises about 4500 slides in total, with about 310 slides containing type specimens collected from the Arctic to Antarctica. Allgén's publications have to a large extent been ignored by scientists working on marine nematodes, likely because of the poor quality of many of his species descriptions. The authors want to remind the scientific community about the existence of Allgén's collection, its availability for study and its importance for nematode taxonomy and systematics. A complete list of Allgén's publications, a list of all species described by him, and a list of type material available is presented.

  1. Carl gustav jung, quantum physics and the spiritual mind: a mystical vision of the twenty-first century.

    PubMed

    Valadas Ponte, Diogo; Schäfer, Lothar

    2013-12-01

    We describe similarities in the ontology of quantum physics and of Carl Gustav Jung's psychology. In spite of the fact that physics and psychology are usually considered as unrelated, in the last century, both of these disciplines have led at the same time to revolutionary changes in the Western understanding of the cosmic order, discovering a non-empirical realm of the universe that doesn't consist of material things but of forms. These forms are real, even though they are invisible, because they have the potential to appear in the empirical world and act in it. We present arguments that force us to believe, that the empirical world is an emanation out of a cosmic realm of potentiality, whose forms can appear as physical structures in the external world and as archetypal concepts in our mind. Accordingly, the evolution of life now appears no longer as a process of the adaptation of species to their environment, but as the adaptation of minds to increasingly complex forms that exist in the cosmic potentiality. The cosmic connection means that the human mind is a mystical mind.

  2. Hermann von Helmholtz and his students

    NASA Astrophysics Data System (ADS)

    Mulligan, Joseph F.

    1989-01-01

    During the years 1871-1888, when Hermann von Helmholtz was professor of physics at the University of Berlin, physicists from all over the world flocked to Berlin to study and do research with him. Among these were the German physicists Max Planck, Heinrich Kayser, Eugen Goldstein, Wilhelm Wien, and Heinrich Hertz, and Americans Henry Rowland, A. A. Michelson, and Michael Pupin. Examples of Helmholtz's scientific and personal interactions with these students and research associates show why he is justly considered the outstanding physics mentor of the 19th century. Both his ideas and his students played a major role in the development of physics in the late 19th and early 20th centuries.

  3. Von Economo neurons in the elephant brain.

    PubMed

    Hakeem, Atiya Y; Sherwood, Chet C; Bonar, Christopher J; Butti, Camilla; Hof, Patrick R; Allman, John M

    2009-02-01

    Von Economo neurons (VENs), previously found in humans, all of the great ape species, and four cetacean species, are also present in African and Indian elephants. The VENs in the elephant are primarily found in similar locations to those in the other species. They are most abundant in the frontoinsular cortex (area FI) and are also present at lower density in the anterior cingulate cortex. Additionally, they are found in a dorsolateral prefrontal area and less abundantly in the region of the frontal pole. The VEN morphology appears to have arisen independently in hominids, cetaceans, and elephants, and may reflect a specialization for the rapid transmission of crucial social information in very large brains.

  4. Johann Philipp von Wurzelbau (1651-1725)

    NASA Astrophysics Data System (ADS)

    Gaab, Hans

    During the turn of the 17th to the 18th century, Johann Philipp von Wurzelbau was the best-known astronomer in Nuremberg. He was a trained merchant, who busied himself in his free hours with astronomy. In the 1680s he became known for his accurate observations of lunar and solar eclipses. At the end of the 1680s he left his trade, and from 1691, he was completely occupied with astronomy. To that end, he constructed a small octagonal observing tower on the roof of his house at Spitzenberg 4. He took the measurement of the solar path and determined the geographical coordinates of Nuremberg. The calendar reform also played a major role in his life.

  5. Dr. von Braun at the Manufacturing and Engineering Laboratory

    NASA Technical Reports Server (NTRS)

    1967-01-01

    Dr. von Braun, Director of the Marshall Space Flight Center, listens attentively to a briefing on the metal forming techniques by Dr. Mathias Siebel of the Manufacturing and Engineering Laboratory at MSFC on October 17, 1967.

  6. 33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE PERISCOPE FROM THE CONTROL ROOM AT TEST STAND NO. 1, PEENEMUENDE. - Marshall Space Flight Center, Redstone Rocket (Missile) Test Stand, Dodd Road, Huntsville, Madison County, AL

  7. Fletcher and von Braun at Apollo 15 launch

    NASA Technical Reports Server (NTRS)

    1971-01-01

    Recently appointed NASA Administrator Dr. James C. Fletcher, left, and Dr. Wernher von Braun, Deputy Associate Administrator for Planning, monitor Apollo 15 prelaunch activities in Firing Room 1 of the Launch Control Center and the Kennedy Space Center, Florida.

  8. Dr. Wernher Von Braun examines a ruby crystal.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, and Dr. Eberhard Rees (left), deputy director, technical, examine a ruby crystal used in laser experiments in the Marshall Center's Space Sciences Laboratory.

  9. 7. Historic American Buildings Survey, Charles Von Urban, Photographer June ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Historic American Buildings Survey, Charles Von Urban, Photographer June 23, 1936, INTERIOR-PARLOR SHOWING FIREPLACE, WINDOWN TRIM, AND CORNICE. - George Fordham House, 329 Cherry Street, New York County, NY

  10. Physik gestern und heute Von der Metallstange zum Hochenergielaser

    NASA Astrophysics Data System (ADS)

    Heering, Peter

    2002-05-01

    Im Mai 1752 wurde in Marly bei Paris auf Anregung des amerikanischen Forschers und Politikers Benjamin Franklin erstmals die elektrische Natur des Blitzes nachgewiesen. Damals beschrieb Franklin auch eine technische Vorrichtung, die als Schutz von Gebäuden vor Blitzschlägen dienen sollte: den Blitzableiter. Diese aus heutiger Sicht scheinbar triviale Vorrichtung wurde aber keineswegs unmittelbar akzeptiert. Und bis heute ist die Forschung zum Schutz von Einrichtungen vor Blitzschlägen nicht abgeschlossen.

  11. Gastrointestinal angiodysplasia and bleeding in von Willebrand disease.

    PubMed

    Franchini, M; Mannucci, P M

    2014-09-02

    Von Willebrand disease (VWD), the most common genetic bleeding disorder, is characterised by a quantitative or qualitative defect of von Willebrand factor (VWF). Patients with VWD suffer from mucocutaneous bleeding, of severity usually proportional to the degree of VWF defect. In particular, gastrointestinal bleeding associated with angiodysplasia is often a severe symptom of difficult management. This review focuses on the pathophysiology, diagnosis and treatment of VWD-associated gastrointestinal angiodysplasia and related bleeding.

  12. Management of Type 2B von Willebrand Disease during Pregnancy.

    PubMed

    McLaughlin, David; Kerr, Ron

    2017-01-01

    Type 2B von Willebrand disease is a rare bleeding condition resulting in thrombocytopenia and a reduction in large VWF multimers. It usually has an autosomal dominant pattern of inheritance. We report the management of a patient with type 2B von Willebrand disease, whose diagnosis was confirmed by demonstration of a R1306W mutation, through her first pregnancy. The patient's von Willebrand factor (VWF) antigen and VWF ristocetin cofactor levels rose throughout pregnancy, with an associated drop in the platelet count. The patient was successfully managed through labour to a surgical delivery with VWF concentrate, platelet transfusions and tranexamic acid. The patient delivered a male baby who was found to have inherited type 2B von Willebrand disease and had a significant cephalhaematoma at delivery. The baby was managed with VWF concentrate and platelet transfusions and made a full recovery. There is a lack of evidence to guide the best management of pregnant patients with type 2B von Willebrand disease. We adopted a pragmatic management plan, in keeping with other published case reports. To the best of our knowledge, this is the first case report in which the child was found to have inherited type 2B von Willebrand disease and encountered bleeding problems, making this case unique amongst the published literature.

  13. Study of types of some species of "Filaria" (Nematoda) parasites of small mammals described by Von Linstow and Molin.

    PubMed

    Guerrero, R; Bain, O

    2011-05-01

    Parasitic nematodes from the Berlin (ZMB) and Vienna (NMW) Museum collections referred to the genus Filaria Mueller, 1787 by von Linstow or Molin were studied. Three samples were in good condition and the specimens redescribed. Litomosa hepatica (von Linstow, 1897) n. comb., sample ZMB Vermes Entozoa 3368, from the megachiropteran Pteropus neohibernicus, Bismarck Archipelago, resembles L. maki Tibayrenc, Bain & Ramanchandran, 1979, from Pteropus vampyrus, in Malaysia, but the buccal capsule differs. Both species display particular morphological characters which differ from species of Litomosa parasitic in microchiropterans. The remaining material originates from Brazil. The spicule morphology of Litomosoides circularis (von Linstow, 1899) Chandler, 1931, sample ZMB Vermes Entozoa 1059 from Hesperomys spec. (= Holochilus brasiliensis), Porto Alegre, confirms that it belongs to the sigmodontis group; the microfilaria presents characters of the genus Litomosoides, e.g. body attenuated at both extremities and salient cephalic hook. Taxonomic discussions by others confirm that species of Litomosoides belonging to the sigmodontis group and described subsequently are distinct from L. circularis. Litomosoides serpicula (Molin, 1858) Guerrero, Martin, Gardner & Bain, 2002, is redescribed, sample NMW 6323 from the bat Phyllostoma spiculatum (= Sturnira lilium), Ypanema. It is very close to L. brasiliensis Almeida, 1936, type host Moytis sp., but distinguished by a single ring in the buccal capsule, rather than two, supporting previous conclusions that the taxon L. brasiliensis, as generally regarded, may represent a complex of species. Samples NMW 6322 and NMW 6324, from other bats and also identified by Molin (1858) as Filaria serpicula, contain unidentifiable fragments of Litomosoides incertae sedis. Filaria hyalina von Linstow, 1890, sample ZMB Vermes Entozoa Q 3905 from Sorer vulgaris (= Sorex araneus), is incertae sedis because it contains two unidentifiable posterior

  14. von Willebrand factor expression in osteosarcoma metastasis.

    PubMed

    Eppert, Kolja; Wunder, Jay S; Aneliunas, Vicky; Kandel, Rita; Andrulis, Irene L

    2005-03-01

    A number of genes are implicated in the initiation and progression of osteosarcoma; however, cytogenetic and comparative genomic hybridization studies indicate the involvement of additional unidentified genes. An examination of gene expression profiles in 22 high-grade osteosarcoma tumor specimens from 15 patients (including paired primary and metastatic samples from five patients) indicated that von Willebrand factor (vWF) mRNA expression may increase during tumor progression. vWF, a large glycoprotein previously considered to be expressed exclusively by endothelial cells and megakaryocytes, is involved in platelet aggregation and adhesion to the subendothelial matrix, processes critical to hematogenous tumor cell metastasis to the lung. Analysis of paired primary and metastatic osteosarcoma tumor samples from 10 patients revealed an increase in vWF gene expression in metastases (P=0.005). Immunohistochemistry showed that, in addition to the endothelial cells, vWF protein was also detected in osteosarcoma cells in vivo in 13 of 29 tumor specimens as well as in SAOS2, an osteosarcoma cell line. The tumor cell staining correlated positively with high vWF expression in the sample (P=0.006). Although vascular endothelial cells contribute to the vWF mRNA detected in the tumor samples, there was neither any correlation between vascular density (VD) and vWF mRNA expression nor between VD and clinical outcome. These findings suggest that vWF expression is deregulated in osteosarcoma tumors, potentially contributing to metastasis.

  15. Unwinding the von Willebrand factor strings puzzle.

    PubMed

    De Ceunynck, Karen; De Meyer, Simon F; Vanhoorelbeke, Karen

    2013-01-10

    von Willebrand factor (VWF) is amongst others synthesized by endothelial cells and stored as ultra-large (UL) VWF multimers in Weibel-Palade bodies. Although UL-VWF is proteolysed by ADAMTS13 (a disintegrin-like and metalloprotease domain with thrombospondin type-1 motif, number 13) on secretion from endothelial cells, in vitro experiments in the absence of ADAMTS13 have demonstrated that a proportion of these UL-VWF multimers remain anchored to the activated endothelium. These multimers unravel, bind platelets, and wave in the direction of the flow. These so-called VWF "strings" have also been visualized in vivo, lining the lumen of activated mesenteric veins of Adamts13(-/-) mice. Various studies have demonstrated the extraordinary length of these VWF strings, the availability of their platelet binding and ADAMTS13 cleavage sites, and the possible nature of their endothelial attachment. VWF strings are also capable of tethering leukocytes and parasite-infected red blood cells. However, the majority of studies have been performed in the absence of ADAMTS13, a condition only experienced in thrombotic thrombocytopenic purpura. A normal functional role of VWF strings in healthy persons or in other disease pathologies remains unclear. In this review, we discuss some of the puzzling characteristics of VWF strings, and we debate whether the properties of VWF strings in the absence of ADAMTS13 might be relevant for understanding (patho)physiologic mechanisms.

  16. Exponential Size Distribution of von Willebrand Factor

    PubMed Central

    Lippok, Svenja; Obser, Tobias; Müller, Jochen P.; Stierle, Valentin K.; Benoit, Martin; Budde, Ulrich; Schneppenheim, Reinhard; Rädler, Joachim O.

    2013-01-01

    Von Willebrand Factor (VWF) is a multimeric protein crucial for hemostasis. Under shear flow, it acts as a mechanosensor responding with a size-dependent globule-stretch transition to increasing shear rates. Here, we quantify for the first time, to our knowledge, the size distribution of recombinant VWF and VWF-eGFP using a multilateral approach that involves quantitative gel analysis, fluorescence correlation spectroscopy, and total internal reflection fluorescence microscopy. We find an exponentially decaying size distribution of multimers for recombinant VWF as well as for VWF derived from blood samples in accordance with the notion of a step-growth polymerization process during VWF biosynthesis. The distribution is solely described by the extent of polymerization, which was found to be reduced in the case of the pathologically relevant mutant VWF-IIC. The VWF-specific protease ADAMTS13 systematically shifts the VWF size distribution toward smaller sizes. This dynamic evolution is monitored using fluorescence correlation spectroscopy and compared to a computer simulation of a random cleavage process relating ADAMTS13 concentration to the degree of VWF breakdown. Quantitative assessment of VWF size distribution in terms of an exponential might prove to be useful both as a valuable biophysical characterization and as a possible disease indicator for clinical applications. PMID:24010664

  17. [Determination of von Willebrand factor multimers in Mexican population].

    PubMed

    Hernández-Zamora, Edgar; Zavala-Hernández, Cesar; Viveros-Sandoval, Martha Eva; Ochoa-Rico, Angeles; Martínez-Murillo, Carlos; Reyes-Maldonado, Elba

    2014-01-01

    Antecedentes: la enfermedad de von Willebrand es un padecimiento hereditario en el que la estructura, función y concentración del factor de von Willebrand están alteradas y, en consecuencia, también la interacción plaqueta-factor de von Willebrand-endotelio. En México no hay registros epidemiológicos de la enfermedad, sólo se han efectuado algunos estudios aislados desde el punto de vista clínico y hematológico. Material y métodos: estudio retrospectivo efectuado en 155 mexicanos mestizos, 75 de ellos con diagnóstico presuntivo de enfermedad de von Willebrand, 15 con sospecha de hemofilia A y 65 donadores sanos (testigos). Se realizaron pruebas: básicas de coagulación, especiales y de clasificación: análisis de la composición multimérica. Resultados: 15 pacientes se diagnosticaron con hemofilia A; de los 75 sujetos con sospecha de enfermedad de von Willebrand se diagnosticaron 50 de la manera siguiente: tipo 1 (62%), tipo 2 (22%) [subtipos: 2A (14%), 2B (2%) y 2N (6%)] y tipo 3 (16%). Conclusión: el análisis de los multímeros del factor de von Willebrand es un método que cumple con las características adecuadas para el diagnóstico de la enfermedad de von Willebrand, por lo que es necesario implementar esta metodología para su estudio y mejorar su diagnóstico específico.

  18. Berechnung von Nichtlinearitätsparametern von RF MOS Mischern mittels Volterra-Reihen

    NASA Astrophysics Data System (ADS)

    Susic, A.; Darrat, A. H.; Mathis, W.

    2011-07-01

    Die Nichtlinearität einer Mischerschaltung bezüglich des Informationssignals führt zu unerwünschten Spektralanteilen am Ausgang des Mischers. Da nicht alle Spektralanteile kritisch sind, müssen bei einer Nichtlinearitätsanalyse nur bestimmte Spektralanteile ermittelt werden. In dieser Arbeit wird ein Verfahren zur Bestimmung der Spektralanteile der Zustandsgrößen im Mischer mit Hilfe der Volterra-Reihe gezeigt. Das Verfahren basiert auf die Methode der nichtlinearen Stromquellen. Es wird sowohl auf nicht-schaltende als auch schaltende Mischer angewendet. Hierbei wird der erste als ein zeitinvariantes System mit zwei Eingängen und der zweite als ein periodisch zeitvariantes System mit einem Eingang modelliert. Das Verfahren wird in dem Computeralgebraprogramm MAPLE für den einfach balancierten MOS Mischer implementiert. Es ermöglicht die Herleitung von semi-symbolischen Ausdrücken für die Spektralanteile in Abhängigkeit von den Entwurfsparametern. Die numerischen Ergebnisse des Verfahrens werden gegenüber Simulationen mit SpectreRF verglichen.

  19. Recombinant von Willebrand factor: a first-of-its-kind product for von Willebrand disease.

    PubMed

    Singal, M; Kouides, P A

    2016-12-01

    von Willebrand disease (VWD) is caused by quantitative or qualitative defects in von Willebrand factor (VWF). The mainstay of therapy is desmopressin, which is, however, not useful in certain forms of VWD notwithstanding adverse events. For these patients, plasma-derived factor VIII (pdFVIII)/VWF concentrates have been available for close to three decades but have a theoretical risk of disease transmission, hypersensitivity/allergic reactions, inhibitors and thrombosis. A recombinant VWF (vonicog alfa, Vonvendi™; manufactured by Baxalta, now part of Shire) was approved by the U.S. Food and Drug Administration (FDA) in December 2015. This review will survey the literature based on a MEDLINE review on the safety, efficacy and pharmacokinetics of Vonvendi. It will also summarize the ongoing studies on Vonvendi available in the public domain. Vonvendi may have an important role in the management of VWD. However, more studies are needed, especially in special populations such as surgical patients, patients with major gastrointestinal bleeding from arteriovenous malformations and pregnant women and children, who are most likely to benefit from it.

  20. Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease

    PubMed Central

    Casonato, Alessandra; Cattini, Maria Grazia; Daidone, Viviana; Pontara, Elena; Bertomoro, Antonella; Prandoni, Paolo

    2016-01-01

    Von Willebrand disease (VWD) may be caused by an impaired von Willebrand factor (VWF) synthesis, its increased clearance or abnormal function, or combinations of these factors. It may be difficult to recognize the different contributions of these anomalies. Here we demonstrate that VWD diagnostics gains from measuring platelet VWF, which can reveal a defective VWF synthesis. Measuring platelet VWF revealed that: severe type 1 VWD always coincided with significantly lower platelet and plasma VWF levels, whereas mild forms revealed low plasma VWF levels associated with low or normal platelet VWF levels, and the latter were associated with a slightly shorter VWF survival; type Vicenza (the archetype VWD caused by a reduced VWF survival) featured normal platelet VWF levels despite significantly reduced plasma VWF levels; type 2B patients could have either normal platelet VWF levels associated with abnormal multimer patterns, or reduced platelet VWF levels associated with normal multimer patterns; type 2A patients could have reduced or normal platelet VWF levels, the former associated mainly with type 2A-I, the latter with type 2A-II; plasma and platelet VWF levels were normal in type 2N, except when the defect was associated with a quantitative VWF mutation. Our findings show that measuring platelet VWF helps to characterize VWD, especially the ambiguous phenotypes, shedding light on the mechanisms underlying the disorder. PMID:27532107

  1. Locally Compact Quantum Groups. A von Neumann Algebra Approach

    NASA Astrophysics Data System (ADS)

    Van Daele, Alfons

    2014-08-01

    In this paper, we give an alternative approach to the theory of locally compact quantum groups, as developed by Kustermans and Vaes. We start with a von Neumann algebra and a comultiplication on this von Neumann algebra. We assume that there exist faithful left and right Haar weights. Then we develop the theory within this von Neumann algebra setting. In [Math. Scand. 92 (2003), 68-92] locally compact quantum groups are also studied in the von Neumann algebraic context. This approach is independent of the original C^*-algebraic approach in the sense that the earlier results are not used. However, this paper is not really independent because for many proofs, the reader is referred to the original paper where the C^*-version is developed. In this paper, we give a completely self-contained approach. Moreover, at various points, we do things differently. We have a different treatment of the antipode. It is similar to the original treatment in [Ann. Sci. & #201;cole Norm. Sup. (4) 33 (2000), 837-934]. But together with the fact that we work in the von Neumann algebra framework, it allows us to use an idea from [Rev. Roumaine Math. Pures Appl. 21 (1976), 1411-1449] to obtain the uniqueness of the Haar weights in an early stage. We take advantage of this fact when deriving the other main results in the theory. We also give a slightly different approach to duality. Finally, we collect, in a systematic way, several important formulas. In an appendix, we indicate very briefly how the C^*-approach and the von Neumann algebra approach eventually yield the same objects. The passage from the von Neumann algebra setting to the C^*-algebra setting is more or less standard. For the other direction, we use a new method. It is based on the observation that the Haar weights on the C^*-algebra extend to weights on the double dual with central support and that all these supports are the same. Of course, we get the von Neumann algebra by cutting down the double dual with this unique

  2. Biosynthesis of von Willebrand protein by human megakaryocytes.

    PubMed

    Sporn, L A; Chavin, S I; Marder, V J; Wagner, D D

    1985-09-01

    Immunofluorescence staining of buffy coat smears from a patient with chronic myelogenous leukemia in accelerated phase showed that approximately 13% of all nucleated cells contained von Willebrand protein and, therefore, appeared to be of megakaryocytic origin. This was confirmed by positive staining with antisera against platelet factor 4 and platelet glycoproteins. Short-term cultures of the buffy coat, which lacked endothelial cells, were metabolically labeled with [35S]methionine, and von Willebrand protein was immunopurified from cell lysates and culture medium. Cultures from this patient synthesized and secreted von Willebrand protein, in contrast with cultures from other patients with leukemia, who lacked circulating megakaryocytes, and from normal volunteers. The subunit composition of the megakaryocytic von Willebrand protein was very similar to that of human umbilical vein endothelial cells. The size of the processed subunit (220 kD) and of the cellular (260 kD) and secreted (275 kD) precursors from the two cell types were indistinguishable by gel electrophoresis. Furthermore, the ratio of precursor to processed subunit and the pattern of cellular and secreted nonreduced multimers were very similar. It appears, therefore, that the processing steps in biosynthesis of von Willebrand protein used by the megakaryocytes are very similar to those of umbilical vein endothelial cells.

  3. Biographical sketch: Georg Hermann von Meyer (1815-1892).

    PubMed

    Skedros, John G; Brand, Richard A

    2011-11-01

    This biographical sketch on Georg Hermann von Meyer highlights the interactions in the 1860s that von Meyer, a famous anatomist, had with Karl Culmann, a famous structural engineer and mathematician. The published papers from this interaction caught the attention of Julius Wolff and stimulated his development of the trajectorial hypothesis of bone adaptation--now called "Wolff's Law." The corresponding translations are provided: (1) von Meyer's 1867 paper that highlights the regularity of arched trabecular patterns in various human bones, and his discussions with Culmann about their possible mechanical relevance; and (2) Wolff's 1869 paper that first mentions the correspondence of stress trajectories in a solid, crane-like structure to the arched trabecular patterns in the proximal human femur. This biographical sketch on Georg Hermann von Meyer corresponds to the historic texts, The Classic: The Architecture of the Trabecular bone (by von Meyer), and The Classic: On the Significance of the Architecture of the Spongy Substance for the Question of Bone Growth. A preliminary publication (by Wolff) available at DOIs 10.1007/s11999-011-2041-5 , 10.1007/s11999-011-2042-4 .

  4. Thrombospondin-1 in von Willebrand factor function.

    PubMed

    Bonnefoy, Arnaud; Hoylaerts, Marc F

    2008-10-01

    Thrombospondin-1 (TSP1), expressed in many cells and tissues is abundantly present in platelet alpha-granules, from where it is released upon platelet activation. Murine Tsp1(-/-) platelet studies have revealed that TSP1 is redundant for platelet aggregation, but that it reinforces platelet aggregate stabilization, especially in a shear field. von Willebrand factor (VWF), synthesized by megakaryocytes and endothelial cells is stored both in platelet alpha-granules and in endothelial Weibel-Palade bodies as ultralarge multimers. When released from endothelial cells, these multimers are temporarily retained on the endothelium, to be cleaved by the plasma protease ADAMTS13 into smaller and hemostatically less reactive multimers, released in plasma. This protease shows partial sequence identity with the type 1 (TSR1) and type 2 (TSR2) repeats of TSP1 and contains 1 TSR1 and 6 TSR2 repeats. TSP1, locally released by platelets, competes with ADAMTS13 during VWF proteolysis and controls the degree of VWF multimer processing. In addition, TSP1 and VWF both interact with the platelet GPIb/V/IX membrane complex, primarily in flow. These interactions control the recruitment of platelets to (sub) endothelial VWF and TSP1, exposed to the circulation, as a consequence of vascular inflammation and endothelial injury. TSP1-VWF interactions do not strictly enhance platelet recruitment and secreted TSP1 even weakly competes with the dynamic platelet rolling and adhesion onto VWF. Hence, TSP1 and VWF show partially related hemostatic functions, the most important one being the TSP1 role in the ADAMTS13 operated VWF multimer processing, in pro-inflammatory and thrombogenic conditions.

  5. America's First Carl Sagan: Ormsby MacKnight Mitchel, Pre-Civil War Astronomer and Lecturer on the Cosmos

    NASA Astrophysics Data System (ADS)

    Osterbrock, D. E.

    2002-12-01

    In the years before television, videos, radio. movies, or even loudspeakers, Ormsby MacKnight Mitchel (1809-1862) was the best-known popularizer of astronomy and the scientific study of the universe in nineteenth-century America. Each winter he traveled the country by railroad, steamer, and stagecoach, speaking to large paying crowds in principal cities from Boston, New York, and Philadelphia through Cincinnati to New Orleans on the cosmos and our place in it, with special attention to possible inhabitants of planers orbiting other stars. Mitchel had much the same attraction as Sagan did in our time, and awakened many people's interest in astronomy through the human angle, as Carl did. His argument was simple, and according to Frank Triplett goes back thousands of years: other stars are suns, our sun has planets with people on one of them, why should not other stars also have populated planets? But first Mitchel, like Sagan, always explained clearly the discoveries of astronomy that fleshed out this argument with facts. He emphasized the ``clockwork universe", governed by gravity, that Newton, Herschel, and Laplace had investigated and found to be stable. There were many other similarities between these two great popularizers. Mitchel's base was the Cincinnati Observatory, which he had founded, raising the funds for it himself in small contributions from hundreds of ``members", which he publicised as far more democratic than support from European kings and lords. He went abroad to get a telescope, and finally found his ``Great [12-inch] Refractor" in Munich, with help from John Quincy Adams, Astronomer Royal George Biddle Airy, and Paris Observatory Director Fracois Arago, in spite of a rebuff by President John Tyler. These episodes have similarities in Sagan's lobbying NASA for close-up images of Mars. Views of other American professional astronomers on life on other worlds will also be described briefly, from Denison Olmsted, Elias Loomis, Charles A. Young (who

  6. An Application of the Von Karman-millikan Laminar Boundary-layer Theory and Comparison with Experiment

    NASA Technical Reports Server (NTRS)

    Von Doenhoff, Albert E

    1935-01-01

    The von Karman-Millikan theory of laminar boundary layers presented in NACA Technical Report No. 504 is applied to the laminar boundary layer about an elliptic cylinder on which boundary-layer and pressure-distribution measurements were made. An outline of the procedure of the von Karman-Millikan method is given. Good agreement is obtained between the calculated and experimental results, indicating that the method may be applied generally to the laminar boundary layer about any body provided that an experimentally determined pressure distribution is available. It appears that for all Reynolds Number above 24,000 the separation point for the elliptic cylinder should occur at a constant distance behind the point of minimum pressure, provided that the boundary layer does not become turbulent.

  7. Periodisches Hitzdrahtverfahren zur Messung von Wärme- und Temperaturleitfähigkeit von geringen Stoffmengen

    NASA Astrophysics Data System (ADS)

    Griesinger, A.; Spindler, K.; Hahne, E.

    Zusammenfassung Es wird ein Meßverfahren zur gleichzeitigen Bestimmung der Wärme- und der Temperaturleitfähigkeit von geringen Stoffmengen beschrieben. Neben Messungen an hochviskosen Flüssigkeiten eignet sich das Verfahren besonders für Messungen an Pulver-Schüttungen. Das Meßverfahren basiert auf dem transienten Hitzdraht-Verfahren. In einem dünnen Platindraht fließt ein sinusförmiger Wechselstrom, der den Draht periodisch erwärmt. Es entstehen thermische Wellen, die in die umgebende Probe eindringen. Die Amplitude und die Phasenlage der thermischen Wellen in der Probe hängen von der Temperaturleitfähigkeit a und der Wärmeleitfähigkeit λ der Probe ab. Die Temperaturschwingung in der Probe wird mit Hilfe des Platindrahtes gemessen, der gleichzeitig als Widerstandsthermometer eingesetzt wird. Meßwerte von Wasser und Glycerin zeigen eine gute Übereinstimmung mit Literaturwerten. Das Meßverfahren zeichnet sich dadurch aus, daß zur Bestimmung der Wärme- und Temperaturleitfähigkeit nur 13 ml einer Probe benötigt werden. Es werden Meßwerte einer Zeolith-Schüttung unter Wasserstoffbeladung dargestellt. A measuring procedure for the simultaneous determination of the thermal conductivity and thermal diffusivity of small quantities is described. The procedure is suited for high-viscous fluids and for powdery material. The measuring principle is based on the transient hot-wire method. A sinusoidal alternating current flows through a thin platinum wire and heats up the wire periodically. This results in thermal waves, which penetrate into the surrounding sample. The amplitude and the phase shift of the thermal waves depend on the thermal diffusivity ``a'' and the thermal conductivity ``λ'' of the sample. The temperature oscillation in the sample is measured by means of the platinum wire, which is simultaneously applied as a resistance thermometer. The values measured for water and glycerine correspond well to those given in literature. Results of the

  8. Committee Opinion No.580: von Willebrand disease in women.

    PubMed

    2013-12-01

    Von Willebrand disease, the most common inherited bleeding disorder among American women, is a common cause of heavy menstrual bleeding and other bleeding problems in women and adolescent girls. Von Willebrand disease and other inherited and acquired disorders of coagulation and hemostasis should be considered in the differential diagnosis of all patients being evaluated for heavy menstrual bleeding, regardless of age. There are many treatment options available for patients with von Willebrand disease and heavy menstrual bleeding, including hormonal and nonhormonal therapies. A multidisciplinary approach to management, which involves obstetrician-gynecologists and hematologists, results in optimal treatment outcomes. Many resources exist for patients and health care providers through the National Heart, Lung, and Blood Institute; National Hemophilia Foundation; and the American Society of Hematology.

  9. Endothelial dysfunction in von Willebrand disease: angiogenesis and angiodysplasia.

    PubMed

    Randi, Anna M

    2016-05-01

    In recent years, new functions for the haemostatic protein von Willebrand Factor (VWF) have emerged. Amongst these is the ability to modulate the development of new blood vessels, a process called angiogenesis. The subtle effects that VWF exerts on blood vessel formation and stability may be relevant for the small but significant fraction of patients with von Willebrand disease (VWD) who also present with vascular malformations (angiodysplasia) in the gastrointestinal tract, often responsible for intractable bleeding. This review will briefly summarise the evidence and discuss the molecular pathways involved.

  10. An Accurate von Neumann's Law for Three-Dimensional Foams

    SciTech Connect

    Hilgenfeldt, Sascha; Kraynik, Andrew M.; Koehler, Stephan A.; Stone, Howard A.

    2001-03-19

    The diffusive coarsening of 2D soap froths is governed by von Neumann's law. A statistical version of this law for dry 3D foams has long been conjectured. A new derivation, based on a theorem by Minkowski, yields an explicit analytical von Neumann's law in 3D which is in very good agreement with detailed simulations and experiments. The average growth rate of a bubble with F faces is shown to be proportional to F{sup 1/2} for large F , in contrast to the conjectured linear dependence. Accounting for foam disorder in the model further improves the agreement with data.

  11. Weibel-Palade bodies: a window to von Willebrand disease.

    PubMed

    Valentijn, K M; Eikenboom, J

    2013-04-01

    Weibel-Palade bodies (WPBs) are the storage organelles for von Willebrand factor (VWF) in endothelial cells. VWF forms multimers that assemble into tubular structures in WPBs. Upon demand, VWF is secreted into the blood circulation, where it unfolds into strings that capture platelets during the onset of primary hemostasis. Numerous mutations affecting VWF lead to the bleeding disorder von Willebrand disease. This review reports the recent findings on the effects of VWF mutations on the biosynthetic pathway of VWF and its storage in WPBs. These new findings have deepened our understanding of VWF synthesis, storage, secretion, and function.

  12. Carl Sagan's Cosmic Connection

    NASA Astrophysics Data System (ADS)

    Sagan, Carl; Agel, Jerome

    2000-08-01

    Foreword Freeman Dyson; Personal reflections Ann Druyan; Preface; Part I. Cosmic Perspective: 1. A transitional animal; 2. The Unicorn of Cetus; 3. A message from earth; 4. A message to earth; 5. Experiments in utopias; 6. Chauvinism; 7. Space exploration as a human enterprise I. The scientific interest; 8. Space exploration as a human enterprise II. The public interest; 9. Space exploration as a human enterprise III. The historical interest; Part II. The Solar System: 10. On teaching the first grade; 11. 'The ancient and legendary Gods of old'; 12. The Venus detective story; 13. Venus is hell; 14. Science and 'intelligence'; 15. The moons of Barsoom; 16. The mountains of Mars I. Observations from earth; 17. The mountains of Mars II. Observations from space; 18. The canals of Mars; 19. The lost pictures of Mars; 20. The Ice Age and the cauldron; 21. Beginnings and ends of the Earth; 22. Terraforming the plants; 23. The exploration and utlization of the solar system; Part III. Beyond the Solar System: 24. Some of my best friends are dolphins; 25. 'Hello, central casting? Send me twenty extraterrestrials'; 26. The cosmic connection; 27. Extraterrestrial life: an idea whose time has come; 28. Has the Earth been visited?; 29. A search strategy for detecting extraterrestrial intelligence; 30. If we succeed 31. Cables, drums, and seashells; 32. The night freight to the stars; 33. Astroengineering; 34. Twenty questions: a classification of cosmic civilisations; 35. Galactic cultural exchanges; 36. A passage to elsewhere; 37. Starfolk I. A Fable; 38. Starfolk II. A future; 39. Starfolk III. The cosmic Cheshire cats; Epilog David Morrison; Index.

  13. Allgemeine Sprachfaehigkeit und Fremdsprachenerwerb. Zur Struktur von Leistungsdimensionen und linguistischer Kompetenz des Fremdsprachenlerners (General Language Ability and Foreign Language Acquisition. On the Structure of Performance Dimensions and the Linguistic Competence of the Foreign Language Learner). Diskussions beitraege aus dem Institute fuer Bildungsforschung, No. 1.

    ERIC Educational Resources Information Center

    Sang, Fritz; Vollmer, Helmut J.

    This study investigates the theoretical plausibility and empirical validity of the assumption that all performance in a foreign language can be traced back to a single factor, the general language ability factor. The theoretical background of this hypothesis is reviewed in detail. The concept of a unitary linguistic competence, interpreted as an…

  14. Targeted therapy for genetic cancer syndromes: Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome.

    PubMed

    Agarwal, Rishi; Liebe, Sarah; Turski, Michelle L; Vidwans, Smruti J; Janku, Filip; Garrido-Laguna, Ignacio; Munoz, Javier; Schwab, Richard; Rodon, Jordi; Kurzrock, Razelle; Subbiah, Vivek

    2015-02-01

    Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome are cancer syndromes which affect multiple organs and lead to significant decline in quality of life in affected patients. These syndromes are rare and typically affect the adolescent and young adult population, resulting in greater cumulative years of life lost. Improved understanding of the underpinnings of the genetic pathways underlying these syndromes and the rapid evolution of targeted therapies in general have made it possible to develop therapeutic options for these patients and other genetic cancer syndromes. Targeted therapies especially antiangiogenics and inhibitors of the PIK3CA/AKT/mTOR signaling pathway have shown activity in selected group of patients affected by these syndromes or in patients harboring specific sporadic mutations which are otherwise characteristic of these syndromes. Unfortunately due to the rare nature, patients with these syndromes are not the focus of clinical trials and unique results seen in these patients can easily go unnoticed. Most of the data suggesting benefits of targeted therapies are either case reports or small case series. Thus, a literature review was indicated. In this review we explore the use of molecularly targeted therapy options in Von Hippel-Lindau disease, Cowden syndrome, and Proteus syndrome.

  15. [Obstetric analgesia and anesthesia with remifentanyl in a patient with von Willebrand disease].

    PubMed

    Novoa, L; Navarro Egea, M; Vieito Amor, M; Hernández Iniesta, J; Arxer, A; Villalonga, A

    2003-05-01

    A 30-year-old woman with von Willebrand's disease was admitted in labor. As epidural analgesia was ruled out due to risk of spinal hematoma, a pump for patient-controlled analgesia (PCA) was provided with boluses of remifentanil and set for intravenous infusion of 24 micrograms with a lockout time of 5 minutes. The patient reported analgesia to be satisfactory. Later, because of abnormal fetal positioning, an emergency cesarean was performed with the patient under general anesthesia with remifentanil, with propofol and succinylcholine for induction. A healthy girl was born free of respiratory depression. Von Willebrand's disease is a hemorrhagic disorder of autosomal dominant inheritance due to a quantitative or functional factor VIII deficit. Various subtypes and degrees of severity of abnormal bleeding have been described. It is the most common genetic hemostatic disorder affecting obstetric procedures, and although epidural analgesia has been used with strict hematologic monitoring, that technique carries a risk of hematoma. PCA is useful in patients for whom regional techniques are contraindicated. With adequate fetal and maternal monitoring, remifentanil in PCA is safe and more effective than other opiates for labor pain.

  16. Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure

    ERIC Educational Resources Information Center

    Joldersma, Clarence W.

    2011-01-01

    In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

  17. Dr. von Braun Conferring With NASA Headquarters Officials

    NASA Technical Reports Server (NTRS)

    1961-01-01

    This photograph, dated November 13, 1961, shows Dr. von Braun conferring with two officials from NASA Headquarters. Dr. Brainered Holmes is on the left. Dr. Nicholas Golovin is in the center. Holmes was Director of NASA's Office of Marned Space Flight. Golovin was Director of Systems Engineering at Headquarters.

  18. Von Kármán between Aachen and Pasadena

    NASA Astrophysics Data System (ADS)

    Krause, Egon; Kalkmann, Ulrich

    2013-05-01

    In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

  19. Dr. Wernher Von Braun near the mobile launcher.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

  20. Wernher von Braun: Reflections on His Contributions to Space Exploration

    NASA Technical Reports Server (NTRS)

    Goldman, Arthur E.

    2012-01-01

    In 1950, Dr. Wernher von Braun and approximately 100 of his team members came to Huntsville, Alabama, to begin work with the Army on what would later become America's historic space program. He would later serve as the first director of the Marshall Space Flight Center and led the development of the Saturn V launch vehicle that launched seven crewed American mission to the moon, as well as America s first space station, Skylab. Von Braun is best known for his team s technical achievements. He realized his dream of exploring outer space by helping place humans on the moon. His engineering and managerial talent during the Apollo era had contributed to a technological revolution. He was by all accounts a good engineer, but he was only one among many. What set Von Braun apart were his charisma, his vision, and his leadership skills. He inspired loyalty and dedication in the people around him. He understood the importance of communicating his vision to his team, to political and business leaders and the public. Today, the Marshall Center continues his vision by pursuing engineering and scientific projects that will continue to open space to exploration. This presentation will discuss Von Braun's impact on Huntsville, the Marshall Center, the nation and the world and look at his contributions in context of where world space exploration is today.

  1. Current therapy in children and adolescents with von Willebrand disease.

    PubMed

    Buga-Corbu, I; Arion, C

    2014-06-15

    The article represents a review of recent data about the therapy of von Willebrand disease in children and adolescents (hereditary as well as acquired forms of the disease). The treatment of bleeding events in these patients, the indications in different subtypes, and the future lines of research are mentioned.

  2. von Braun Examines Bendix Mobility Test Article (MTA)

    NASA Technical Reports Server (NTRS)

    1964-01-01

    Marshall Space Flight Center (MSFC) director, Wernher von Braun, and others examine one concept of a possible Lunar Roving Vehicle (LRV) built by the Bendix Corporation. The data provided by the MTA helped in designing the LRV, developed under the direction of MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions.

  3. von Braun Examines Bendix Mobility Test Article (MTA)

    NASA Technical Reports Server (NTRS)

    1965-01-01

    Marshall Space Flight Center (MSFC) director, Wernher von Braun, and a visitor, examine one concept of a possible Lunar Roving Vehicle (LRV) built by the Bendix Corporation. The data provided by the MTA helped in designing the LRV, developed under the direction of MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions.

  4. Dr. von Braun With a Model of a Launch Vehicle

    NASA Technical Reports Server (NTRS)

    1950-01-01

    Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

  5. Treasure in the Library Attic: Von Ranke at Syracuse.

    ERIC Educational Resources Information Center

    Coville, Bruce

    1984-01-01

    Traces history of private library of German scholar, Leopold von Ranke, which was purchased by Syracuse University in 1888. Efforts of librarian Charles W. Bennett in 1870s and Professor James Powell beginning in late 1960s, and restoration and cataloging of collection are highlighted. Items from the collection are noted. (EJS)

  6. The Influence of Field Marshal Colmar Von Der Goltz on Ottoman Military Effectiveness in Mesopotamia: December 1915 to April 1916

    DTIC Science & Technology

    2012-02-23

    the Ottoman Fifth Army was activated to defend the Dardanelles, and the Ottomans gave Limon von Sanders command. With Limon von Sanders’ move to...Fifth Army, von der Goltz took command of the First Army and the German military mission which were both previously commanded by Limon von Sanders.51

  7. Möbius operators and non-additive quantum probabilities in the Birkhoff-von Neumann lattice

    NASA Astrophysics Data System (ADS)

    Vourdas, A.

    2016-03-01

    The properties of quantum probabilities are linked to the geometry of quantum mechanics, described by the Birkhoff-von Neumann lattice. Quantum probabilities violate the additivity property of Kolmogorov probabilities, and they are interpreted as Dempster-Shafer probabilities. Deviations from the additivity property are quantified with the Möbius (or non-additivity) operators which are defined through Möbius transforms, and which are shown to be intimately related to commutators. The lack of distributivity in the Birkhoff-von Neumann lattice Λd, causes deviations from the law of the total probability (which is central in Kolmogorov's probability theory). Projectors which quantify the lack of distributivity in Λd, and also deviations from the law of the total probability, are introduced. All these operators, are observables and they can be measured experimentally. Constraints for the Möbius operators, which are based on the properties of the Birkhoff-von Neumann lattice (which in the case of finite quantum systems is a modular lattice), are derived. Application of this formalism in the context of coherent states, generalizes coherence to multi-dimensional structures.

  8. State of Maine Annual Performance Report on Applied Technology Programs Funded under the Carl D. Perkins Vocational and Applied Technology Act (P.L. 101-392). Program Year 1993-1994.

    ERIC Educational Resources Information Center

    Maine State Dept. of Education, Augusta. Div. of Applied Technology.

    This report summarizes 1993-1994 program year developments in Maine's applied technology programs funded under the 1990 Carl D. Perkins Act. The first section highlights the following program activities: continued development of Maine's integrated school-to-work transition system, which will allow secondary students to choose one of six career…

  9. The Carl D. Perkins Vocational and Applied Technology Education Act Amendments of 1990. Conference Report To Accompany H.R. 7. House of Representatives, 101st Congress, 2d Session.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. House.

    This document reports the committee of the conference's recommendation that the U.S. House of Representatives recede from its disagreement to the U.S. Senate amendment on the Carl D. Perkins Vocational and Applied Technology Education Act amendments of 1990. The first section provides materials the Senate would have inserted in the amendments. The…

  10. English for Specific Purposes: Building a Curricular Bridge between English as a Second Language and Vocational/Business Office Systems. A Carl D. Perkins Vocational and Applied Technology Education Program Improvement Grant. Final Report.

    ERIC Educational Resources Information Center

    Austin Community Coll., TX.

    This 11-page report describes a project wherein a Carl D. Perkins Vocational and Applied Technology Program Improvement Grant was used to develop a curricular bridge between the academic English-as-a-Second-Language (ESL) area and the vocational-technical business/office systems area of Austin Community College (ACC). The following project…

  11. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease

    PubMed Central

    Gill, Joan C.; Castaman, Giancarlo; Windyga, Jerzy; Kouides, Peter; Ragni, Margaret; Leebeek, Frank W. G.; Obermann-Slupetzky, Ortrun; Chapman, Miranda; Fritsch, Sandor; Pavlova, Borislava G.; Presch, Isabella

    2015-01-01

    This phase 3 trial evaluated the safety and hemostatic efficacy of a recombinant von Willebrand factor (rVWF) for treatment of bleeds in severe von Willebrand disease (VWD). rVWF was initially administered together with recombinant factor VIII (rFVIII) and subsequently alone, as long as hemostatic factor VIII activity (FVIII:C) levels were maintained. Pharmacokinetics (PK) were evaluated in a randomized cross-over design (rVWF vs rVWF:rFVIII at 50 IU VWF:ristocetin cofactor activity [RCo]/kg). Bleed control for all treated bleeds (N = 192 bleeds in 22 subjects) was rated good or excellent (96.9% excellent; 119 of 122 minor, 59 of 61 moderate, and 6 of 7 major bleeds) on a 4-point scale (4 = none to 1 = excellent). A single infusion was effective in 81.8% of bleeds. Treatment success, defined as the number of subjects with a mean efficacy rating of <2.5, was 100%. The PK profile of rVWF was not influenced by rFVIII (mean VWF:RCo terminal half-life: 21.9 hours for rVWF and 19.6 hours for rVWF:rFVIII). FVIII:C levels increased rapidly after rVWF alone, with hemostatic levels achieved within 6 hours and sustained through 72 hours after infusion. Eight adverse events (AEs; 6 nonserious AEs in 4 subjects and 2 serious AEs [chest discomfort and increased heart rate, without cardiac symptomatology] concurrently in 1 subject) were associated with rVWF. There were no thrombotic events or severe allergic reactions. No VWF or FVIII inhibitors, anti-VWF binding antibodies, or antibodies against host cell proteins were detected. These results show that rVWF was safe and effective in treating bleeds in VWD patients and stabilizes endogenous FVIII:C, which may eliminate the need for rFVIII after the first infusion. This trial was registered at www.clinicaltrials.gov as #NCT01410227. PMID:26239086

  12. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease.

    PubMed

    Gill, Joan C; Castaman, Giancarlo; Windyga, Jerzy; Kouides, Peter; Ragni, Margaret; Leebeek, Frank W G; Obermann-Slupetzky, Ortrun; Chapman, Miranda; Fritsch, Sandor; Pavlova, Borislava G; Presch, Isabella; Ewenstein, Bruce

    2015-10-22

    This phase 3 trial evaluated the safety and hemostatic efficacy of a recombinant von Willebrand factor (rVWF) for treatment of bleeds in severe von Willebrand disease (VWD). rVWF was initially administered together with recombinant factor VIII (rFVIII) and subsequently alone, as long as hemostatic factor VIII activity (FVIII : C) levels were maintained. Pharmacokinetics (PK) were evaluated in a randomized cross-over design (rVWF vs rVWF:rFVIII at 50 IU VWF:ristocetin cofactor activity [RCo]/kg). Bleed control for all treated bleeds (N = 192 bleeds in 22 subjects) was rated good or excellent (96.9% excellent; 119 of 122 minor, 59 of 61 moderate, and 6 of 7 major bleeds) on a 4-point scale (4 = none to 1 = excellent). A single infusion was effective in 81.8% of bleeds. Treatment success, defined as the number of subjects with a mean efficacy rating of <2.5, was 100%. The PK profile of rVWF was not influenced by rFVIII (mean VWF:RCo terminal half-life: 21.9 hours for rVWF and 19.6 hours for rVWF:rFVIII). FVIII : C levels increased rapidly after rVWF alone, with hemostatic levels achieved within 6 hours and sustained through 72 hours after infusion. Eight adverse events (AEs; 6 nonserious AEs in 4 subjects and 2 serious AEs [chest discomfort and increased heart rate, without cardiac symptomatology] concurrently in 1 subject) were associated with rVWF. There were no thrombotic events or severe allergic reactions. No VWF or FVIII inhibitors, anti-VWF binding antibodies, or antibodies against host cell proteins were detected. These results show that rVWF was safe and effective in treating bleeds in VWD patients and stabilizes endogenous FVIII : C, which may eliminate the need for rFVIII after the first infusion. This trial was registered at www.clinicaltrials.gov as #NCT01410227.

  13. Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease.

    PubMed Central

    Levene, R B; Booyse, F M; Chediak, J; Zimmerman, T S; Livingston, D M; Lynch, D C

    1987-01-01

    Studies were conducted to characterize the biosynthesis of von Willebrand factor (vWf) by cultured endothelial cells (EC) derived from the umbilical vein of a patient with type IIA von Willebrand disease. The patient's EC, compared with those from normal individuals, produced vWf that had decreased amounts of large multimers and an increase in rapidly migrating satellite species, features characteristic of plasma vWf from patients with type IIA von Willebrand disease. The type IIA EC did produce a full spectrum of vWf multimers in both cell lysates and postculture medium, although the relative amounts of the largest species were decreased. The large multimers were degraded in conjunction with the appearance of rapidly migrating satellites that contained approximately equal to 170-kDa proteolytic fragments, suggesting that this patient's functional defect is due to abnormal proteolysis and not to a primary failure of vWf subunit oligomerization. Moreover, the observed degradation appears to result from an abnormal vWf molecule and not elevated protease levels. These results suggest that this patient's von Willebrand disease phenotype is caused by increased proteolytic sensitivity of his vWf protein. Images PMID:3306682

  14. The Time of Grand Strategy

    DTIC Science & Technology

    2013-03-01

    Development”, China Economist, no. 01 (2007). 19 Carl von Clausewitz, On War (Princeton, NJ: Princeton University Press, 1989), VII.22. 20 Carl von...Clausewitz, Ibid., VIII.2. 21 Carl von Clausewitz, Ibid., IV.12. 22 Harold Nelson, “Space and Time in On War”, Clausewitz and Modern Strategy (Towata, NJ...Frank Cass & Co., 1986), 138. 23 Carl von Clausewitz, On War, V.8; Harold Nelson, “Space and Time in On War, 143. 24 Carl von Clausewitz, On War., I

  15. Carl D. Perkins Vocational Education Act. Hearing before the Select Committee on Indian Affairs on S. 496 To Amend the Carl D. Perkins Vocational Education Act To Establish a Program of Grants for Vocational-Technical Training and To Encourage Tribal Economic Development, To Provide for the Designation of the National Indian Center for Research in Vocational-Technical Training. United States Senate, One Hundred First Congress, First Session (September 15, 1989).

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Indian Affairs.

    This document contains the text of a Senate hearing examining proposed changes (S. 496) to the Carl D. Perkins Vocational Education Act. The amendment would take effect in October 1991 to establish a program of grants for vocational-technical training and to provide for the designation of the National Indian Center for Research in…

  16. Binding of atoms and stability of molecules in Hartree and Thomas-Fermi type theories. Part I: A necessary and sufficient condition for the stability of general molecular systems

    SciTech Connect

    Catto, I.; Lions, P.L. )

    1992-01-01

    The authors study here the binding of atoms and molecules and the stability of general molecular systems including molecular ions. This is the first paper of a series devoted to the study of these general problems. The authors obtain here a general necessary and sufficient condition for the stability of a general molecular system in the context of Thomas-Fermi-Von Weizsaecker, Thomas-Fermi-Dirac-Von Weizsaecker, Hartree or Hartree-Fock theories. 20 refs.

  17. Types of species of Apionidae (Coleoptera) described by Carl Peter Thunberg (1743–1828) with description of a new genus

    PubMed Central

    Alonso-Zarazaga, Miguel A.

    2013-01-01

    Abstract The type specimens of species of Apionidae described by Carl Peter Thunberg are reviewed and lecto- and paralectotypes are designated for Apion craccae Thunberg, 1813, Apion limbatum Thunberg, 1813, Apion punctigerum Thunberg, 1815 and Apion astragali Thunberg, 1815. A new genus Thunbergapion (type species Apion limbatum Thunberg, 1813) is described, figured and placed in the tribe Aplemonini Kissinger, 1968. The new combination Thunbergapion limbatum (Thunberg, 1813) is proposed. A key to the known South African genera of the tribe is given. The following new synonymies are established: Oxystoma craccae (Linnaeus, 1767) = Apion craccae Thunberg, 1813 syn. n., Ischnopterapion (Ischnopterapion) loti (Kirby, 1808) = Apion punctigerum Thunberg, 1815, syn. n., and Pseudoprotapion astragali (Paykull, 1800) = Apion astragali Thunberg, 1815, syn. n. PMID:23950673

  18. Modern embalming, circulation of fluids, and the voyage through the human arterial system: Carl L. Barnes and the culture of immortality in America.

    PubMed

    Podgorny, Irina

    2011-01-01

    By considering the work of American embalmer, lawyer, and physician Carl Lewis Barnes (1872-1927), this paper analyzes the emergence of modern embalming in America. Barnes experimented with and exhibited the techniques by which embalming fluids travelled into the most remote cavities of the human body. In this sense, modem embalmers based their skills and methods on experimental medicine, turning the anatomy of blood vessels, physiology of circulation, and composition of blood into a circuit that allowed embalming fluids to move throughout the corpse. Embalmers in the late 19th century took ownership of the laws of hydrodynamics and the physiology of blood circulation to market their fluids and equipment, thus playing the role of physiologists of death, performing and demonstrating physiological experiments with dead bodies.

  19. Types of species of Apionidae (Coleoptera) described by Carl Peter Thunberg (1743-1828) with description of a new genus.

    PubMed

    Alonso-Zarazaga, Miguel A

    2013-01-01

    The type specimens of species of Apionidae described by Carl Peter Thunberg are reviewed and lecto- and paralectotypes are designated for Apion craccae Thunberg, 1813, Apion limbatum Thunberg, 1813, Apion punctigerum Thunberg, 1815 and Apion astragali Thunberg, 1815. A new genus Thunbergapion (type species Apion limbatum Thunberg, 1813) is described, figured and placed in the tribe Aplemonini Kissinger, 1968. The new combination Thunbergapion limbatum (Thunberg, 1813) is proposed. A key to the known South African genera of the tribe is given. The following new synonymies are established: Oxystoma craccae (Linnaeus, 1767) = Apion craccae Thunberg, 1813 syn. n., Ischnopterapion (Ischnopterapion) loti (Kirby, 1808) = Apion punctigerum Thunberg, 1815, syn. n., and Pseudoprotapion astragali (Paykull, 1800) = Apion astragali Thunberg, 1815, syn. n.

  20. Phylogenetic analysis of the Australian trans-Bass Strait millipede genus Pogonosternum (Carl, 1912) (Diplopoda, Polydesmida, Paradoxosomatidae) indicates multiple glacial refugia in southeastern Australia

    PubMed Central

    Decker, Peter

    2016-01-01

    Abstract This study documents the first detailed phylogenetic analysis of an Australian paradoxosomatid millipede genus. Two mitochondrial genes (partial COI and 16S) as well as partial nuclear 28S rDNA were amplified and sequenced for 41 individuals of the southeastern Australian genus Pogonosternum Jeekel, 1965. The analysis indicates that five species groups of Pogonosternum occur across New South Wales, Victoria and Tasmania: Pogonosternum nigrovirgatum (Carl, 1912), Pogonosternum adrianae Jeekel, 1982, Pogonosternum laetificum Jeekel, 1982 and two undescribed species. Pogonosternum coniferum (Jeekel, 1965) specimens cluster within Pogonosternum nigrovirgatum. Most of these five species groups exhibit a pattern of high intraspecific genetic variability and highly localized haplotypes, suggesting that they were confined to multiple Pleistocene refugia on the southeastern Australian mainland. The phylogenetic data also show that northwestern Tasmania was colonized by Pogonosternum nigrovirgatum, probably from central Victoria, and northeastern Tasmania by an as yet undescribed species from eastern Victoria. PMID:27110194

  1. PREFACE: EmerQuM 11: Emergent Quantum Mechanics 2011 (Heinz von Foerster Congress)

    NASA Astrophysics Data System (ADS)

    Grössing, Gerhard

    2012-05-01

    These proceedings comprise the plenary lectures and poster contributions of the 'Heinz von Foerster Conference 2011' on Emergent Quantum Mechanics (EmerQuM11), which was held at the University of Vienna, 11-13 November 2011. With the 5th International Heinz von Foerster Conference convened at the occasion of von Foerster's 100th birthday, the organizers opted for a twin conference to take place at the Large and Small Ceremonial Halls of the University's main building, respectively. The overall topic was chosen as 'Self-Organization and Emergence', a topic to which von Foerster was an early contributor. While the first conference ('Self-Organization and Emergence in Nature and Society') addressed a more general audience, the second one ('Emergent Quantum Mechanics') was intended as a specialist meeting with a contemporary topic that could both serve as an illustration of von Foerster's intellectual heritage and, more generally, point towards future directions in physics. We thus intended to bring together many of those physicists who are interested in or are working on attempts to understand quantum mechanics as emerging from a suitable classical (or, more generally, deeper level) physics. EmerQuM11 was organized by the Austrian Institute for Nonlinear Studies (AINS), with essential support from the Wiener Institute for Social Science Documentation and Methodology (WISDOM), the Department of Contemporary History at the University of Vienna, and the Heinz von Foerster-Gesellschaft. There were a number of individuals who contributed to the smooth course of our meeting and whom I would like to sincerely thank: Christian Bischof, Thomas Elze, Marianne Ertl, Gertrud Hafner, Werner Korn, Angelika Krawanja, Florian Krug and his team, Sonja Lang, Albert Müller, Ilse Müller, Irene Müller, Karl Müller, Armin Reautschnig, Marion Schirrmacher, Anton Staudinger, Roman Zlabinger, and, last but not least, my AINS colleagues Siegfried Fussy, Herbert Schwabl and Johannes Mesa

  2. Principles of care for the diagnosis and treatment of von Willebrand disease.

    PubMed

    Castaman, Giancarlo; Goodeve, Anne; Eikenboom, Jeroen

    2013-05-01

    Von Willebrand disease is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in circulation. As a result of von Willebrand factor deficiency or abnormality, levels of factor VIII, the protein deficient in hemophilia A, may be variably reduced. Clinical manifestations are mainly represented by mucous membrane and of soft tissue bleeding. Their severity is variable depending on the degree of von Willebrand factor and factor VIII reduction. While a clear-cut diagnosis is easy in severe von Willebrand factor reductions, the advantage of pursuing a definite diagnosis in mild or dubious cases should be weighed against the risk of over-medicalization. The aim of treatment is to correct the dual defect of hemostasis caused by the abnormal/reduced von Willebrand factor and the concomitant deficiency of factor VIII. Desmopressin is the treatment of choice for type 1 von Willebrand disease patients with factor VIII and von Willebrand factor levels of 10 U/dL or over who have proved responsive to a test-infusion with the compound. Von Willebrand factor/factor VIII concentrates are needed when desmopressin is ineffective (mainly type 2 and 3 von Willebrand disease).

  3. Pathological Changes of von Economo Neuron and Fork Neuron in Neuropsychiatric Diseases.

    PubMed

    Liu, Jia; Wang, Lu-ning; Arzberger, Thomas; Zhu, Ming-wei

    2016-02-01

    von Economo neuron (VEN) is a bipolar neuron characterized by a large spindle-shaped soma. VEN is generally distributed in the layer V of anterior insular lobe and anterior cingulate cortex. Fork neuron is another featured bipolar neuron. In recent years,many studies have illustrated that VEN and fork neurons are correlated with complicated cognition such as self-consciousness and social emotion. Studies in the development and morpholigies of these two neurons as well as their pathological changes in various neurological and psychiatric disorders have found that the abnormal number and functions of VEN can cause corresponding dysfunctions in social recognition and emotions both during the neuro-developmental stages of childhood and during the nerve degeneration in old age stage. Therefore, more attentions should be paid on the research of VEN and fork neurons in neuropsychiatric diseases.

  4. Altered megakaryocytopoiesis in von Willebrand type 2B disease.

    PubMed

    Nurden, A T; Federici, A B; Nurden, P

    2009-07-01

    Type 2B von Willebrand disease (VWD2B) is caused by gain-of-function amino acid substitutions in the von Willebrand factor (VWF) A1 domain. These allow facilitated binding of mutated VWF to platelet GPIbalpha with prolonged lifetimes of VWF bonds and enhanced ADAMTS-13 cleavage of large VWF multimers. A bleeding rather than prothrombotic syndrome is due to: (i) decreased large VWF multimers in plasma; (ii) limited thrombus formation; and (iii) thrombocytopenia affecting some but not all patients. Accumulating evidence points to an altered megakaryocytopoiesis in VWD2B with the production of enlarged or giant platelets showing an abnormal ultrastructure and, in a cohort of patients, the presence of circulating platelet agglutinates. In fact, evidence from in vitro cultures and marrow aspirates suggests that the upregulated VWF function can lead to abnormal VWF trafficking in megakaryocytes, a modified platelet production with interacting proplatelets, and the presence or even release of platelet agglutinates in the bone marrow.

  5. Water Experiments Related To The "Von Karman Sodium" Dynamo Project

    NASA Astrophysics Data System (ADS)

    Marie, L.; Bourgoin, M.; Petrelis, F.; Roy, J.; Burguete, J.; Chiffaudel, A.; Daviaud, F.; Fauve, S.; Odier, P.; Pinton, J.-F.

    2002-07-01

    The purpose of the "Von Karman Sodium" (V.K.S.) experiment is to study the "Dynamo Effect," namely the spontaneous generation of magnetic field in a flow of electrically conducting fluid. The device has been built at CEA / Cadarache, in collaboration with CEA / Saclay, Ecole Normale Superieure de Lyon and Ecole Normale Superieure de Paris. It consists of a cylindrical vessel, filled with liquid Sodium, in which two coaxial rotating disks induce a Von-Karman type flow. Several experimental runs have taken place since June 2000. In order to optimize the V.K.S. set-up, a half-scale water prototype has also been built. It has allowed us to measure mean velocity profiles, as well as pressure fluctuations and mechanical power dissipation. We have observed that under certain circumstances the mean component of the turbulent flow can undergo a global bifurcation.

  6. An update on type 2B von Willebrand disease.

    PubMed

    Mikhail, Sameh; Aldin, Ehab Saad; Streiff, Michael; Zeidan, Amer

    2014-04-01

    Type 2B von Willebrand disease (VWD) accounts for fewer than 5% of all VWD patients. In this disease, mutations in the A1 domain result in increased von Willebrand factor (VWF) binding to platelet GPIbα receptors, causing increased platelet clearance and preferential loss of high molecular weight VWF multimers. Diagnosis is complicated because of significant clinical variations even among patients with identical mutations. Platelet transfusion often provides suboptimal results since transfused platelets may be aggregated by the patients' abnormal VWF. Desmopressin may cause a transient decrease in platelet count that could lead to an increased risk of bleeding. Replacement therapy with factor VIII/VWF concentrates is the most effective approach to prevention and treatment of bleeding in type 2B VWD.

  7. Marshall-Stickler phenotype associated with von Willebrand disease

    SciTech Connect

    MacDonald, M.R.; Baker, K.S.; Schaefer, G.B.

    1997-01-20

    We report on 6 individuals from three different kindreds with Marshall-Stickler (MS) phenotype, with characteristic orofacial abnormalities, arthropathy, deafness, and eye findings, all of whom were discovered to have a mild bleeding diathesis and coagulation-study findings consistent with mild von Willebrand disease (vWD). MS syndrome has been linked in some cases to the type II procollagen gene (COL2A1) on chromosome 12q, and to the collagen XI gene (COL11A2) on chromosome 6. The von Willebrand factor (vWF) is encoded by a 180-Kb gene located on the short arm of chromosome 12. This is the first reported association of these two disorders. 26 refs., 5 figs., 1 tab.

  8. Interpolatability distinguishes LOCC from separable von Neumann measurements

    SciTech Connect

    Childs, Andrew M.; Leung, Debbie; Mančinska, Laura; Ozols, Maris

    2013-11-15

    Local operations with classical communication (LOCC) and separable operations are two classes of quantum operations that play key roles in the study of quantum entanglement. Separable operations are strictly more powerful than LOCC, but no simple explanation of this phenomenon is known. We show that, in the case of von Neumann measurements, the ability to interpolate measurements is an operational principle that sets apart LOCC and separable operations.

  9. [Clemens Freiherr von Pirquet, developer of the concept of allergy].

    PubMed

    Bergmann, K C

    2006-07-20

    The pediatrician and scientist, Clemens Freiherr von Pirquet (1874-1929) was the first to coin the term "allergy". His experiments with Behring's serum, which he administered to sick children, led him to an awareness of an interaction between the human organism and pathogens. In his article published in the Müncher Medizinischen Wochenschrift in 1906, he laid the foundation stone for modern allergology.

  10. Baron von Zach's business relations with the Munich entrepreneur Joseph von Utzschneider (German Title: Geschäftsbeziehungen des Barons von Zach zu dem Münchner Unternehmer Joseph von Utzschneider)

    NASA Astrophysics Data System (ADS)

    Schneider, Ivo

    The relationship between the astronomer von Zach on the one side and the entrepreneur Joseph von Utzschneider and his partner Georg von Reichenbach on the other dates presumably from the year 1807 when Zach spent two months in Munich. Already in the same year Zach had ordered an instrument for himself and began to solicit business for the institute of Reichenbach, Utzschneider, and Liebherr, which was founded in 1804. One of the clients canvassed by Zach was the director of the observatory in Naples Zuccari. Zuccari had ordered the whole equipment for the new observatory from this institute in 1813. The instruments for Naples, which were completed in 1814, were sent accompanied by Reichenbach by land and sea to their destination where Reichenbach supervised their setup. At that time Reichenbach had separated from Utzschneider who kept the optical institute in Benediktbeuern with his new partner Joseph von Fraunhofer whereas Reichenbach became owner of the mathematical-mechanical institute in Munich. For personal and economical reasons Utzschneider began soon after to produce not only optical glass but also optical devices similar to those offered by Reichenbach. As soon as two institutes in Munich competed against each other on the market for sophisticated geodetical and astronomical instruments Zach sided with Utzschneider. Zach's main professional argument for this decision was that both competitors got the optical glass for their instruments from Utzschneider's optical institute in Benediktbeuern. This meant that Utzschneider had first choice and so the optical part of his instruments could be considered as better than that of Reichenbach`s instruments. Zach's role as an agent in Italy and France for the sale of products coming from Utzschneider's manufactories is highlighted by three of Zach's letters to Utzschneider from 1817 and 1818, two of which are reproduced here for the first time.

  11. Von Humboldt bis Einstein. Berlin als Weltzentrum der exakten Wissenschaften.

    NASA Astrophysics Data System (ADS)

    Meschkowski, H.

    Contents: 1. Die Anfänge. 2. Die Ära Dirichlet-Jacobi. 3. Der Ausbau der experimentellen Naturwissenschaften. 4. Alexander von Humboldt. 5. Berlin wird "Weltzentrum" der Mathematik. 6. Die Ära Helmholtz. 7. Neue Arbeitsweisen der Astronomie. 8. Chemie: Forschung und Industrie. 9. Max Planck. 10. Ins technische Zeitalter. 11. Zur Mathematik der zwanziger Jahre. 12. Albert Einstein. 13. Fortschritte der Grundlagenforschung. 14. Erwin Schrödinger: Physiker, Philosoph und Poet. 15. Zum Schluß.

  12. Johann Baptist von Schweitzer: the queer Marx loved to hate.

    PubMed

    Kennedy, H

    1995-01-01

    Despite his conviction on a morals charge involving a boy, the early German Social Democrat Johann Baptist von Schweitzer went on to have a successful political career. His life furnishes the context to present remarks by his political opponents Marx and Engels, which reveal their deep-seated homophobia. It is pointed out that this has been glossed over by the translations of the recently published Marx/Engels Collected Works. Some remarks on boy-love and anarchism are appended.

  13. Dr. von Braun In Front of a Display of Missiles

    NASA Technical Reports Server (NTRS)

    1960-01-01

    In this photo, Director of the US Army Ballistic Missile Agency (ABMA) Development Operations Division, Dr. Wernher von Braun, is standing before a display of Army missiles celebrating ABMA's Fourth Open House. The missiles in the background include (left to right) a satellite on a Juno II shroud with a Nike Ajax pointing left in front of a Jupiter missile. The Lacrosse is in front of the Juno II. The Nike Hercules points skyward in front of the Juno II and the Redstone.

  14. Screening of Von Willebrand Disease in Iranian Women With Menorrhagia

    PubMed Central

    Rahbar, Nahid; Faranoush, Mohammad; Ghorbani, Raheb; Sadr Alsadat, Bahare

    2015-01-01

    Background: Menorrhagia is a common health problem in women, particularly those with bleeding disorders. Little is known about the course of menorrhagia or other bleeding symptoms in women with the most common congenital bleeding disorder, von Willebrand disease (vWD). Objectives: The aim of this study was to estimate the prevalence of vWD in women with diagnosed menorrhagia. Materials and Methods: In this cross-sectional study, a total of 460 consecutive patients, presenting menorrhagia, were analyzed. The initial screening and confirmation tests for the diagnosis of vWD included determination of prothrombin time (PT), partial thromboplastin time (PTT), bleeding time (BT), fibrinogen, factor VIII, vWF antigen, and vWF activity. A questionnaire was filled for every patient. The data were then analyzed using the SPSS software. Results: Mean age of our patients was 32.5 ± 10.6 years. The level of von Willebrand factor in 22.5% and von Willebrand activity in 19.6% of patients was abnormal. The prevalence of vWD among patients with menorrhagia was 24%. Conclusions: The high prevalence of vWD among our patients was the same as other previous reports, suggesting low awareness about this disease and under diagnosis of mild cases. PMID:25763275

  15. Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation.

    PubMed

    Ruggeri, Z M

    2001-06-01

    The adhesive protein von Willebrand factor mediates the initiation and progression of thrombus formation at sites of vascular injury. von Willebrand factor is synthesized in endothelial cells and megakaryocytes as a very large polymer composed of identical subunits. In the plasma, it appears as a series of multimers of regularly decreasing molecular mass, from several thousand to 500 kDa. The size of circulating von Willebrand factor multimers is controlled by proteolytic cleavage carried out by a specific protease. The biological functions of von Willebrand factor are exerted through specific domains that interact with extracellular matrix components and cell membrane receptors to promote the initial tethering and adhesion of platelets to subendothelial surfaces, as well as platelet aggregation. Moreover, von Willebrand factor binds the procoagulant co-enzyme, factor VIII, contributing to its stability and, indirectly, to its function in the generation of fibrin. This chapter presents a review of current knowledge on the structure, biosynthesis and functions of von Willebrand factor.

  16. Study of types of some species of “Filaria” (Nematoda) parasites of small mammals described by von Linstow and Molin

    PubMed Central

    Guerrero, R.; Bain, O.

    2011-01-01

    Parasitic nematodes from the Berlin (ZMB) and Vienna (NMW) Museum collections referred to the genus Filaria Mueller, 1787 by von Linstow or Molin were studied. Three samples were in good condition and the specimens redescribed. Litomosa hepatica (von Linstow, 1897) n. comb., sample ZMB Vermes Entozoa 3368, from the megachiropteran Pteropus neohibernicus, Bismarck Archipelago, resembles L. maki Tibayrenc, Bain & Ramanchandran, 1979, from Pteropus vampyrus, in Malaysia, but the buccal capsule differs. Both species display particular morphological characters which differ from species of Litomosa parasitic in microchiropterans. The remaining material originates from Brazil. The spicule morphology of Litomosoides circularis (von Linstow, 1899) Chandler, 1931, sample ZMB Vermes Entozoa 1059 from Hesperomys spec. (= Holochilus brasiliensis), Porto Alegre, confirms that it belongs to the sigmodontis group; the microfilaria presents characters of the genus Litomosoides, e.g. body attenuated at both extremities and salient cephalic hook. Taxonomic discussions by others confirm that species of Litomosoides belonging to the sigmodontis group and described subsequently are distinct from L. circularis. Litomosoides serpicula (Molin, 1858) Guerrero, Martin, Gardner & Bain, 2002, is redescribed, sample NMW 6323 from the bat Phyllostoma spiculatum (= Sturnira lilium), Ypanema. It is very close to L. brasiliensis Almeida, 1936, type host Moytis sp., but distinguished by a single ring in the buccal capsule, rather than two, supporting previous conclusions that the taxon L. brasiliensis, as generally regarded, may represent a complex of species. Samples NMW 6322 and NMW 6324, from other bats and also identified by Molin (1858) as Filaria serpicula, contain unidentifiable fragments of Litomosoides incertae sedis. Filaria hyalina von Linstow, 1890, sample ZMB Vermes Entozoa Q 3905 from Sorex vulgaris (= Sorex araneus), is incertae sedis because it contains two unidentifiable posterior

  17. Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall.

    PubMed

    Claes, J; Liesenborghs, L; Peetermans, M; Veloso, T R; Missiakas, D; Schneewind, O; Mancini, S; Entenza, J M; Hoylaerts, M F; Heying, R; Verhamme, P; Vanassche, T

    2017-02-09

    Essentials Staphylococcus aureus (S. aureus) binds to endothelium via von Willebrand factor (VWF). Secreted VWF-binding protein (vWbp) mediates S. aureus adhesion to VWF under shear stress. vWbp interacts with VWF and the Sortase A-dependent surface protein Clumping factor A (ClfA). VWF-vWbp-ClfA anchor S. aureus to vascular endothelium under shear stress.

  18. General Anesthesia

    MedlinePlus

    General anesthesia Overview By Mayo Clinic Staff Under general anesthesia, you are completely unconscious and unable to feel pain during medical procedures. General anesthesia usually uses a combination of intravenous drugs and ...

  19. Radiometric Trouble with Rough Surfaces? ... The von Neumann Series can Help!

    NASA Astrophysics Data System (ADS)

    Davis, A. B.

    2004-05-01

    Operational retrieval methods used in surface remote sensing will generally assume that the interrogated terrain is uniform as well as flat (if not outright horizontal) at least at sub-pixel scales. Both assumptions are highly questionable. There are spectral techniques (linear un-mixing, end-members, etc.) designed to address the non-uniformity issue and adjacency effects (nonlinear mixing) near large gradients in surface albedo can be unraveled with techniques using the Green function of the aerosol atmosphere. But strong deviations from local flatness define a challenging problem in three-dimensional radiative transfer; this is especially true when the terrain has a very rough fractal shape with height variability over a wide range of scales. The source of the problem is the multiple reflections between surface elements in view of each other and is mathematically akin to the problem of multiple scattering in heterogeneous turbid media like clouds. The fundamental solution to the multiple scattering/reflection problem in transport theory is called ``successive orders-of-scattering/reflection'' by physicists and a ``von Neumann expansion'' by mathematicians. I have applied this method to the analysis of two remote sensing problems that appear to be vastly different: (1) angular dependence of effective emissivity in thermal remote sensing, and (2) biases in fine laser altimetry (such as attempted by NASA's present GLAS mission which focuses on polar ice caps). The thermal problem can be reduced to a question of mean aspect ratio in the macro-roughness of the surface. The altimetry problem calls furthermore for a roughness scale. In both cases, corrections can be made to obtain the surface property of interest: actual emissivity, and actual altitude. In both cases, Monte Carlo simulation ---another seminal contribution of John von Neumann, with others--- was the key to first inspiring and then validating the proposed analytical models with one or two free parameters

  20. Generalized Bernoulli-Hurwitz numbers and the universal Bernoulli numbers

    NASA Astrophysics Data System (ADS)

    Ônishi, Yoshihiro

    2011-10-01

    The three fundamental properties of the Bernoulli numbers, namely, the von Staudt-Clausen theorem, von Staudt's second theorem, and Kummer's original congruence, are generalized to new numbers that we call generalized Bernoulli-Hurwitz numbers. These are coefficients in the power series expansion of a higher-genus algebraic function with respect to a suitable variable. Our generalization differs strongly from previous works. Indeed, the order of the power of the modulus prime in our Kummer-type congruences is exactly the same as in the trigonometric function case (namely, Kummer's own congruence for the original Bernoulli numbers), and as in the elliptic function case (namely, H. Lang's extension for the Hurwitz numbers). However, in other past results on higher-genus algebraic functions, the modulus was at most half of its value in these classical cases. This contrast is clarified by investigating the analogue of the three properties above for the universal Bernoulli numbers. Bibliography: 34 titles.

  1. Architects of Air Supremacy: General Hap Arnold and Dr. Theodore von Karman

    DTIC Science & Technology

    1994-01-25

    1903, inventions such as the stirrup (circa 700 A.D. in Western Europe) and gunpowder (circa 1300 A.D. in Western Europe) had " evolutionized " warfare as...officials at other universities held similar beliefs it was Millikan, with help from the Guggenheim Foundation, who made Cal Tech the leader.23 Daniel...missed a great deal. The casual relaxation of the situation was ideal for learning. The professor’s teaching method centered around a belief in

  2. Context-invariant quasi hidden variable (qHV) modelling of all joint von Neumann measurements for an arbitrary Hilbert space

    SciTech Connect

    Loubenets, Elena R.

    2015-03-15

    We prove the existence for each Hilbert space of the two new quasi hidden variable (qHV) models, statistically noncontextual and context-invariant, reproducing all the von Neumann joint probabilities via non-negative values of real-valued measures and all the quantum product expectations—via the qHV (classical-like) average of the product of the corresponding random variables. In a context-invariant model, a quantum observable X can be represented by a variety of random variables satisfying the functional condition required in quantum foundations but each of these random variables equivalently models X under all joint von Neumann measurements, regardless of their contexts. The proved existence of this model negates the general opinion that, in terms of random variables, the Hilbert space description of all the joint von Neumann measurements for dimH≥3 can be reproduced only contextually. The existence of a statistically noncontextual qHV model, in particular, implies that every N-partite quantum state admits a local quasi hidden variable model introduced in Loubenets [J. Math. Phys. 53, 022201 (2012)]. The new results of the present paper point also to the generality of the quasi-classical probability model proposed in Loubenets [J. Phys. A: Math. Theor. 45, 185306 (2012)].

  3. Spin torque oscillator neuroanalog of von Neumann's microwave computer.

    PubMed

    Hoppensteadt, Frank

    2015-10-01

    Frequency and phase of neural activity play important roles in the behaving brain. The emerging understanding of these roles has been informed by the design of analog devices that have been important to neuroscience, among them the neuroanalog computer developed by O. Schmitt and A. Hodgkin in the 1930s. Later J. von Neumann, in a search for high performance computing using microwaves, invented a logic machine based on crystal diodes that can perform logic functions including binary arithmetic. Described here is an embodiment of his machine using nano-magnetics. Electrical currents through point contacts on a ferromagnetic thin film can create oscillations in the magnetization of the film. Under natural conditions these properties of a ferromagnetic thin film may be described by a nonlinear Schrödinger equation for the film's magnetization. Radiating solutions of this system are referred to as spin waves, and communication within the film may be by spin waves or by directed graphs of electrical connections. It is shown here how to formulate a STO logic machine, and by computer simulation how this machine can perform several computations simultaneously using multiplexing of inputs, that this system can evaluate iterated logic functions, and that spin waves may communicate frequency, phase and binary information. Neural tissue and the Schmitt-Hodgkin, von Neumann and STO devices share a common bifurcation structure, although these systems operate on vastly different space and time scales; namely, all may exhibit Andronov-Hopf bifurcations. This suggests that neural circuits may be capable of the computational functionality as described by von Neumann.

  4. Otto von Guericke and 17th century cosmology

    NASA Astrophysics Data System (ADS)

    Knobloch, Eberhard

    Otto von Guericke's scientific method was based on reason and experimental science. His cosmology was embedded in theology and can be interpreted as a refutation of Descartes' worldview. He used Nicolaus Cusanus' theory of quantities in order to characterize space. The notion of space has to be distinguished from that of world or heaven. Forces play a crucial role in this respect described by Athanasius Kircher in his "Celestial Journey". Guericke read this work very diligently. In spite of some obvious similarities between Guericke's and Newton's scientific aims and methods there are crucial differences between the scientific convictions and results of these scholars.

  5. Nutzergerechte Entwicklung der Mensch-Maschine-Interaktion von Fahrerassistenzsystemen

    NASA Astrophysics Data System (ADS)

    König, Winfried

    Durch langjährige Forschungen bei Kfz-Herstellern, Zulieferfirmen und an Hochschulen sind umfangreiche, aber dennoch lückenhafte Erkenntnisse über das Zusammenspiel zwischen FAS und Nutzer gewonnen worden. In deutschen und internationalen Projekten wie z. B. PROMETHEUS, DRIVE, MOTIV, INVENT, RESPONSE und AKTIV haben sich Kfz-Hersteller, Zulieferfirmen, Hochschulen und weitere staatliche und private Forschungseinrichtungen zusammengefunden, um die vorwettbewerbliche Forschung für derartige Systeme voranzutreiben. Im folgenden Kapitel sollen einige der gewonnenen Kenntnisse dargelegt werden, um die Entwicklung des HMI von FAS zu erleichtern.

  6. Kernschmelze Der nachhaltige Einfluss von Nuklearwaffen auf Politik und Wirtschaft

    NASA Astrophysics Data System (ADS)

    Greiner, Bernd

    "Was sollen wir von einer Kultur halten, der die Ethik stets als wesentliches Element des menschlichen Lebens galt, die aber - außer in fachlicher oder spieltheoretischer Terminologie - nicht in der Lage war, über die Möglichkeit zu sprechen, nahezu alle Menschen zu töten?" Der Fragesteller gehört zu den berühmtesten Physikern des 20. Jahrhunderts und zu den nach wie vor Umstrittensten. über ihn wurde in den 1960er Jahren ein international viel beachtetes Theaterstück geschrieben, vor wenigen Jahren gar eine Oper.

  7. Dr. von Braun on the Mobility Test Article (MTA)

    NASA Technical Reports Server (NTRS)

    1966-01-01

    In this June 1966 photograph, Marshall Space Flight Center Director Dr. Wernher von Braun test-drives the Mobility Test Article (MTA), a developmental vehicle built by the Bendix Corporation to test lunar mobility vehicle concepts. The data provided by the MTA helped in designing the Lunar Roving Vehicle (LRV), developed under the direction of the MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions. The LRVs were deployed during the last three Apollo missions; Apollo 15, Apollo 16, and Apollo 17.

  8. Dr. von Braun Driving the Mobility Test Article

    NASA Technical Reports Server (NTRS)

    1966-01-01

    In this June, 1966 photograph, Marshall Space Flight Center Director, Dr. Wernher von Braun test drives the Mobility Test Article (MTA), a developmental vehicle built by the Bendix Corporation to test lunar mobility concepts. The data provided by the MTA helped in designing the Lunar Roving Vehicle (LRV), developed under the direction of the Marshall Space Flight Center. The LRV was designed to allow Apollo astronauts a greater range during lunar exploration missions and served its purpose during the last three Apollo lunar missions in 1971 and 1972.

  9. Effect of Genetic Variation in STXBP5 and STX2 on von Willebrand Factor and Bleeding Phenotype in Type 1 von Willebrand Disease Patients

    PubMed Central

    van Loon, Janine E.; Sanders, Yvonne V.; de Wee, Eva M.; Kruip, Marieke J. H. A.; de Maat, Moniek P. M.; Leebeek, Frank W. G.

    2012-01-01

    Background In type 1 von Willebrand Disease (VWD) patients, von Willebrand Factor (VWF) levels and bleeding symptoms are highly variable. Recently, the association between genetic variations in STXBP5 and STX2 with VWF levels has been discovered in the general population. We assessed the relationship between genetic variations in STXBP5 and STX2, VWF levels, and bleeding phenotype in type 1 VWD patients. Methods In 158 patients diagnosed with type 1 VWD according to the current ISTH guidelines, we genotyped three tagging-SNPs in STXBP5 and STX2 and analyzed their relationship with VWF:Ag levels and the severity of the bleeding phenotype, as assessed by the Tosetto bleeding score. Results In STX2, rs7978987 was significantly associated with VWF:Ag levels (bèta-coefficient (β) = −0.04 IU/mL per allele, [95%CI −0.07;−0.001], p = 0.04) and VWF:CB activity (β = −0.12 IU/mL per allele, [95%CI −0.17;−0.06], p<0.0001). For rs1039084 in STXBP5 a similar trend with VWF:Ag levels was observed: (β = −0.03 IU/mL per allele [95% CI −0.06;0.003], p = 0.07). In women, homozygous carriers of the minor alleles of both SNPs in STXBP5 had a significantly higher bleeding score than homozygous carriers of the major alleles. (Rs1039084 p = 0.01 and rs9399599 p = 0.02). Conclusions Genetic variation in STX2 is associated with VWF:Ag levels in patients diagnosed with type 1 VWD. In addition, genetic variation in STXBP5 is associated with bleeding phenotype in female VWD patients. Our findings may partly explain the variable VWF levels and bleeding phenotype in type 1 VWD patients. PMID:22792389

  10. The Fate of Western Civilization: G. H. von Wright's Reflections on Science, Technology, and Global Society

    ERIC Educational Resources Information Center

    Heikkero, Topi

    2004-01-01

    This article introduces the central ideas of G. H. von Wright's cultural philosophy concerning the techno-scientific form of life. Georg Henrik von Wright (1916-2003) was best known for his achievements in the field of modal logic and for his association with Ludwig Wittgenstein. However, his work also included a critical analysis of science and…

  11. 76 FR 36166 - Culturally Significant Objects Imported for Exhibition; Determinations: “Gabriel von Max: Be...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition; Determinations: ``Gabriel von Max: Be-Tailed Cousins... the exhibition ``Gabriel von Max: Be-Tailed Cousins and Phantasms of the Soul,'' imported from...

  12. An Alternative Perspective on von Winterfeldt et al.'s (1997) Test of Consequence Monotonicity

    ERIC Educational Resources Information Center

    Ho, Moon-Ho R.; Regenwetter, Michel; Niederee, Reinhard; Heyer, Dieter

    2005-01-01

    D. von Winterfeldt, N.-K. Chung, R. D. Luce, and Y. Cho (see record 1997-03378-008) provided several tests for consequence monotonicity of choice or judgment, using certainty equivalents of gambles. The authors reaxiomatized consequence monotonicity in a probabilistic framework and reanalyzed von Winterfeldt et al.'s main experiment via a…

  13. A taxonomic synopsis of South American Cyanogomphini Carle with description of Cyanogomphus angelomachadoi sp. nov. from the Cerrado of Brazil (Odonata: Gomphidae).

    PubMed

    Pinto, Ângelo Parise; Almeida, Marcus Vinícius Oliveira De

    2016-02-09

    A synopsis of Cyanogomphini Carle, 1986 (sensu Belle 1996), including all species currently under the genera Cyanogomphus Selys, 1873, and Tibiagomphus Belle, 1992, is provided. Cyanogomphus angelomachadoi sp. nov. (Holotype ♂ deposited in DZRJ: Brazil, Minas Gerais State, Jaboticatubas municipality, Parque Nacional da Serra do Cipó, collecting site "Córrego das Pedras" 19°22'17"S, 43°36'03"W, 766 m a.s.l., 12.XII.2011, A.P.M. Santos & D.M. Takiya leg.) is described and illustrated based on four males and two females from Minas Gerais and São Paulo States, southeastern Brazil. The new species is most similar to C. waltheri Selys, 1873, from which it can be distinguished by its smaller size; larger pale areas on mesepisternum; pale dorsal surface of metathoracic tibia; larger distal concavity on epiproct, with laterodistal projection, in lateral view forefinger-shaped; and occurrence in Cerrado province. Five species are recognized in Cyanogomphini, and for each one a synonymy, diagnoses, identification key and maps of distribution are presented. The status of sibling taxa Tibiagomphus uncatus (Fraser, 1947) and T. noval (Rodrigues Capítulo, 1985), as well as the Agriogomphus-complex of genera are also discussed.

  14. General anesthesia

    MedlinePlus

    ... page: //medlineplus.gov/ency/article/007410.htm General anesthesia To use the sharing features on this page, please enable JavaScript. General anesthesia is treatment with certain medicines that puts you ...

  15. von Baer's law for the ages: lost and found principles of developmental evolution.

    PubMed

    Abzhanov, Arhat

    2013-12-01

    In 1828, Karl Ernst von Baer formulated a series of empirically defined rules, which became widely known as the 'Law of Development' or 'von Baer's law of embryology'. This was one the most significant attempts to define the principles that connected morphological complexity and embryonic development. Understanding this relation is central to both evolutionary biology and developmental genetics. Von Baer's ideas have been both a source of inspiration to generations of biologists and a target of continuous criticism over many years. With advances in multiple fields, including paleontology, cladistics, phylogenetics, genomics, and cell and developmental biology, it is now possible to examine carefully the significance of von Baer's law and its predictions. In this review, I argue that, 185 years after von Baer's law was first formulated, its main concepts after proper refurbishing remain surprisingly relevant in revealing the fundamentals of the evolution-development connection, and suggest that their explanation should become the focus of renewed research.

  16. Karl ernst von Baer's 'Uber Entwickelungsgeschichte der Thiere II' and its unpublished drawings.

    PubMed

    Tammiksaar, Erki; Brauckmann, Sabine

    2004-01-01

    In 1828 Karl Ernst von Baer (1792-1876) published his seminal Uber Entwickelungsgeschichte der Thiere. Beobachtung und Reflexion. In the preface he announced that a second volume with one copper plate would be finished 'in a few weeks'. However, it took nine years until the unfinished second volume was released, with four copperplates. In his 'Autobiography', von Baer did not clarify the reasons why he did not finish his research program of comparative embryology. The paper attempts to elucidate them, furnished by archival documents and von Baer's unpublished embryological drawings. Our sketch of a few figures will show that (1) von Baer searched for 'analogies' (homologies) as a unifying principle and (2) explained the mechanisms of embryogenesis by physiological reasoning (electromagnetism). The main objective is to show that technical problems in illustrating and conceptual difficulties impeded von Baer's ambitious research program.

  17. Von Willebrand factor and angiogenesis: basic and applied issues.

    PubMed

    Randi, A M; Laffan, M A

    2017-01-01

    The recent discovery that von Willebrand factor (VWF) regulates blood vessel formation has opened a novel perspective on the function of this complex protein. VWF was discovered as a key component of hemostasis, capturing platelets at sites of endothelial damage and synthesized in megakaryocytes and endothelial cells (EC). In recent years, novel functions and binding partners have been identified for VWF. The finding that loss of VWF in EC results in enhanced, possibly dysfunctional, angiogenesis is consistent with the clinical observations that in some patients with von Willebrand disease (VWD), vascular malformations can cause severe gastrointestinal (GI) bleeding. In vitro and in vivo studies indicate that VWF can regulate angiogenesis through multiple pathways, both intracellular and extracellular, although their relative importance is still unclear. Investigation of these pathways has been greatly facilitated by the ability to isolate EC from progenitors circulating in the peripheral blood of normal controls and patients with VWD. In the next few years, these will yield further evidence on the molecular pathways controlled by VWF and shed light on this novel and fascinating area of vascular biology. In this article, we will review the evidence supporting a role for VWF in blood vessel formation, the link between VWF dysfunction and vascular malformations causing GI bleeding and how they may be causally related. Finally, we will discuss how these findings point to novel therapeutic approaches to bleeding refractory to VWF replacement therapy in VWD.

  18. Interaction of the von Willebrand factor with platelets and thrombosis.

    PubMed

    Perutelli, P; Mori, P G

    1997-11-01

    The human von Willebrand factor (vWf) is a multimeric glycoprotein present in plasma, platelets, endothelial cells and subendothelium and synthesized in endothelial cells and megakaryocytes. vWf plays a pivotal role in the mechanisms of blood clotting and platelet thrombus formation; quantitative and qualitative abnormalities of vWf cause the most common congenital bleeding disorder in man, the von Willebrand disease. vWf stabilizes factor VIII and interacts with subendothelial components and with platelet membrane receptors. The multimeric structure of vWf provides an array of binding sites which allows multivalent interactions with its ligands, thus supporting the formation of stable platelet aggregates at the site of vascular injury, particularly under flow conditions characterized by high shear stress. In the last years, remarkable progress has been made toward understanding the structure of vWf protein and gene, and the elucidation of many structure-function relationships, which may result in improved therapeutic intervention for vWD patients, and in the development of effective strategies for antithrombotic therapy.

  19. Von Braun Rocket Team at Fort Bliss, Texas

    NASA Technical Reports Server (NTRS)

    1940-01-01

    The German Rocket Team, also known as the Von Braun Rocket Team, poses for a group photograph at Fort Bliss, Texas. After World War II ended in 1945, Dr. Wernher von Braun led some 120 of his Peenemuende Colleagues, who developed the V-2 rocket for the German military during the War, to the United Sttes under a contract to the U.S. Army Corps as part of Operation Paperclip. During the following five years the team worked on high altitude firings of the captured V-2 rockets at the White Sands Missile Range in New Mexico, and a guided missile development unit at Fort Bliss, Texas. In April 1950, the group was transferred to the Army Ballistic Missile Agency (ABMA) at Redstone Arsenal in Huntsville, Alabama, and continued to work on the development of the guided missiles for the U.S. Army until transferring to a newly established field center of the National Aeronautic and Space Administration (NASA), George C. Marshall Space Flight Center (MSFC).

  20. von Willebrand factor, Jedi knight of the bloodstream.

    PubMed

    Springer, Timothy A

    2014-08-28

    When blood vessels are cut, the forces in the bloodstream increase and change character. The dark side of these forces causes hemorrhage and death. However, von Willebrand factor (VWF), with help from our circulatory system and platelets, harnesses the same forces to form a hemostatic plug. Force and VWF function are so closely intertwined that, like members of the Jedi Order in the movie Star Wars who learn to use "the Force" to do good, VWF may be considered the Jedi knight of the bloodstream. The long length of VWF enables responsiveness to flow. The shape of VWF is predicted to alter from irregularly coiled to extended thread-like in the transition from shear to elongational flow at sites of hemostasis and thrombosis. Elongational force propagated through the length of VWF in its thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and likely also increases affinity of the A1 domain for platelets. Specialized domains concatenate and compact VWF during biosynthesis. A2 domain unfolding by hydrodynamic force enables postsecretion regulation of VWF length. Mutations in VWF in von Willebrand disease contribute to and are illuminated by VWF biology. I attempt to integrate classic studies on the physiology of hemostatic plug formation into modern molecular understanding, and point out what remains to be learned.

  1. von Willebrand disease: advances in pathogenetic understanding, diagnosis, and therapy.

    PubMed

    Lillicrap, David

    2013-01-01

    von Willebrand disease (VWD) is the most common autosomally inherited bleeding disorder. The disease represents a range of quantitative and qualitative pathologies of the adhesive glycoprotein von Willebrand factor (VWF). The pathogenic mechanisms responsible for the type 2 qualitative variants of VWF are now well characterized, with most mutations representing missense substitutions influencing VWF multimer structure and interactions with platelet GPIbα and collagen and with factor VIII. The molecular pathology of type 3 VWD has been similarly well characterized, with an array of different mutation types producing either a null phenotype or the production of VWF that is not secreted. In contrast, the pathogenetic mechanisms responsible for type 1 VWD remain only partially resolved. In the hemostasis laboratory, the measurement of VWF:Ag and VWF:RCo are key components in the diagnostic algorithm for VWD, although the introduction of direct GPIbα-binding assays may become the functional assay of choice. Molecular genetic testing can provide additional benefit, but its utility is currently limited to type 2 and 3 VWD. The treatment of bleeding in VWD involves the use of desmopressin and plasma-derived VWF concentrates and a variety of adjunctive agents. Finally, a new recombinant VWF concentrate has just completed clinical trial evaluation and has demonstrated excellent hemostatic efficacy and safety.

  2. Developments in the diagnostic procedures for von Willebrand disease.

    PubMed

    De Jong, A; Eikenboom, J

    2016-03-01

    Von Willebrand disease (VWD) is the most common inherited bleeding disorder but its diagnosis can be challenging due to the heterogeneity of the disease. VWD is mainly associated with mild mucocutaneous bleeding, although there are more severe phenotypes with bleeding from the gastrointestinal tract or even the joints. Also, surgical interventions and trauma may lead to critical bleeding events. These bleeding episodes are all related to quantitative or qualitative defects of von Willebrand factor (VWF), a multimeric glycoprotein produced by endothelial cells and megakaryocytes, which mediates platelet adhesion and aggregation and binds factor VIII (FVIII) in the circulation. This review describes the diagnostic procedures required for correct diagnosis. Accurate diagnosis and classification is required for proper treatment and counseling. Assessment of bleeding starts with the medical history. After a positive bleeding or family history, subsequent laboratory investigations will start with a panel of standard screening tests for hemostatic defects. Patients suspected of having VWD will be tested for plasma VWF antigen levels, the ability of VWF to bind platelets and FVIII activity. When VWD is confirmed, a set of subtyping tests can classify the patients as VWD types 1, 2 (A, B, M or N) or 3. The performance of some additional assays and analyses, such as VWF propeptide measurement or genetic analysis, may help in identifying the pathological mechanism behind certain defects or can guide in the choice of treatment.

  3. Prophylaxis in von Willebrand Disease: Coming of Age?

    PubMed

    Saccullo, Giorgia; Makris, Mike

    2016-07-01

    Although in most cases von Willebrand disease (VWD) is a mild disorder, a subgroup of patients experience frequent bleeding. In contrast to severe hemophilia in which prophylaxis is the accepted standard of care, this is less frequently used in VWD. Most type 1 VWD patients can be adequately managed with episodic desmopressin and tranexamic acid. In patients with more severe disease, especially those with type 3 VWD, joint bleeds, epistaxis, menorrhagia, and gastrointestinal bleeding are problematic and usually require treatment with von Willebrand factor/factor VIII (VWF/FVIII) concentrate. While in the past these patients were managed with on-demand VWF/FVIII concentrate, several recent reports have demonstrated the value of prophylactic treatment. Despite some uncertainties about the economic impact of treatment of severe VWD, prophylaxis with VWF concentrate should now be considered as the standard of care for the more severe end of the spectrum of affected individuals. The recent introduction of recombinant VWF concentrate is likely to improve the acceptability of prophylaxis in VWD.

  4. Acquired von Willebrand syndrome in patients with Gaucher disease.

    PubMed

    Mitrovic, Mirjana; Elezovic, Ivo; Miljic, Predrag; Suvajdzic, Nada

    2014-04-01

    Although various coagulation abnormalities occur in patients with Gaucher disease (GD), von Willebrand factor (vWF) deficiency has rarely been reported. A retrospective review of six treatment naïve cases with GD and concomitant vWF deficiency over a 12-year-period in a single center is presented. All patients had a personal history of prior hemorrhages. Based on both reduced level of vWF antigen (vWF:Ag, range 14-56%) and ristocetin cofactor activity (vWF:RCo, range 12-53%), with a vWF:RCo/Ag ratio >0.7, the diagnosis of type 1 von Willebrand disease was made in all six cases. During enzyme replacement therapy (ERT) of a 2-year duration all patients normalized their vWF:Ag levels. Based on the positive ERT effect on vWF:Ag levels, vWF deficiency was assumed to be acquired. It should be noted that beside vWF deficiency four patients with GD exhibited mild thrombocytopenia (range 81-131×10(9)/L) and three had additional hemostatic defects (reduced collagen platelet aggregation, FV, FXI and FXII deficiencies).

  5. A visit paid to Jung by Alwine von Keller.

    PubMed

    Bernardini, Riccardo; Quaglino, Gian Piero; Romano, Augusto

    2011-04-01

    In the winter of 1943-1944, Jung had suffered a coronary thrombosis which almost cost him his life. During his illness, Jung experienced a series of visions, described in his Memories, Dreams, Reflections, which were also to influence significantly the development of his theoretical thinking. On 27(th) September 1944, Alwine von Keller (1878-1965) paid a visit to Jung, while he was still convalescing, in Zurich and documented her meeting with him in a series of notes, recently discovered, which testify to the fact that, at the time of their meeting, Jung was engaged in writing the 'Salt' chapter of Mysterium coniunctionis and investigating the alchemistic symbolism of the 'sea'. This theme seems to testify to a continuity of interests on Jung's part with the seminar he held at Eranos the previous year on the cartographic art of Opicinus de Canistris (1296-c.1352). With its addition of many unpublished details, Alwine von Keller's notes supplement the report which Jung made of his visions experienced during his sickness in MDR. In particular, these attest to the fact that Jung had attributed the terrible experience which he had endured to the problem of the conjunctio, which was confronting him from the theoretical point of view in his writing of Mysterium coniunctionis.

  6. Sexual modernity in the works of Richard von Krafft-Ebing and Albert Moll.

    PubMed

    Oosterhuis, Harry

    2012-04-01

    The modern notion of sexuality took shape at the end of the nineteenth century, especially in the works of Richard von Krafft-Ebing and Albert Moll. This modernisation of sexuality was closely linked to the recognition of sexual diversity, as it was articulated in the medical-psychiatric understanding of what, at that time, was labelled as perversion. From around 1870, psychiatrists shifted the focus from immoral acts, a temporary deviation of the norm, to an innate morbid condition. In the late nineteenth century, several psychiatrists, collecting and publishing more and more case histories, classified and explained the wide range of deviant sexual behaviours they traced. The emergence of medical sexology meant that perversions could be diagnosed and discussed. Against this background both Krafft-Ebing and Moll articulated a new perspective, not only on perversion, but also on sexuality in general. Krafft-Ebing initiated and Moll elaborated a shift from a psychiatric perspective in which deviant sexuality was explained as a derived, episodic and more or less singular symptom of a more fundamental mental disorder, to a consideration of perversion as an integral part of a more general, autonomous and continuous sexual instinct. Before Sigmund Freud and others had expressed similar views, it was primarily through the writings of Krafft-Ebing and Moll that a new understanding of human sexuality emerged.

  7. Sexual Modernity in the Works of Richard von Krafft-Ebing and Albert Moll

    PubMed Central

    Oosterhuis, Harry

    2012-01-01

    The modern notion of sexuality took shape at the end of the nineteenth century, especially in the works of Richard von Krafft-Ebing and Albert Moll. This modernisation of sexuality was closely linked to the recognition of sexual diversity, as it was articulated in the medical–psychiatric understanding of what, at that time, was labelled as perversion. From around 1870, psychiatrists shifted the focus from immoral acts, a temporary deviation of the norm, to an innate morbid condition. In the late nineteenth century, several psychiatrists, collecting and publishing more and more case histories, classified and explained the wide range of deviant sexual behaviours they traced. The emergence of medical sexology meant that perversions could be diagnosed and discussed. Against this background both Krafft-Ebing and Moll articulated a new perspective, not only on perversion, but also on sexuality in general. Krafft-Ebing initiated and Moll elaborated a shift from a psychiatric perspective in which deviant sexuality was explained as a derived, episodic and more or less singular symptom of a more fundamental mental disorder, to a consideration of perversion as an integral part of a more general, autonomous and continuous sexual instinct. Before Sigmund Freud and others had expressed similar views, it was primarily through the writings of Krafft-Ebing and Moll that a new understanding of human sexuality emerged. PMID:23002290

  8. Von Neumann entropy and phase distribution of two mode parametric amplifier interacting with a single atom

    SciTech Connect

    Sebawe Abdalla, M. . E-mail: m.sebawe@physics.org; Obada, A.-S.F.; Abdel-Aty, M.

    2005-08-01

    In the present article, we introduce a Hamiltonian model that consists of two modes of the field in a perfect cavity to interact with a single two-level atom. The interaction between the fields has been taken into account and considered to be in the parametric amplifier form. The model in one hand can be regarded as a generalization of the Jaynes-Cummings model (JCM), however, in the other hand it can be considered as a generalization of the parametric amplifier model. Under a certain condition the exact solution to the Schroedinger equation is obtained. Employing this solution and for chosen values of different parameters we discuss numerically the atomic occupation probabilities as well as the degree of entanglement through the entropy of the field. The system shows superstructure phenomenon similar to that appeared from the effect of the Kerr-like medium on the Jaynes-Cummings model. The von Neumann entropy and phase distribution for both two-mode correlated and uncorrelated coherent states cases are also considered.

  9. Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.

    PubMed

    Guerrero, Jose A; Kyei, Mark; Russell, Susan; Liu, Junling; Gartner, T Kent; Storrie, Brian; Ware, Jerry

    2009-12-24

    Platelet-type von Willebrand disease (PT-VWD) is a bleeding disorder of the platelet glycoprotein Ib-IX/von Willebrand factor (VWF) axis caused by mutations in the glycoprotein Ib-IX receptor that lead to an increased affinity with VWF. In this report, platelets from a mouse expressing a mutation associated with PT-VWD have been visualized using state-of-the art image collection and processing. Confocal analysis revealed that VWF bound to the surface of single platelets and bridging micro-aggregates of platelets. Surface-bound VWF appears as a large, linear structure on the surface of 50% of the PT-VWD platelets. In vivo thrombus formation after chemical injury to the carotid artery revealed a severe impairment to occlusion as a consequence of the PT-VWD mutation. In vitro stimulation of PT-VWD platelets with adenosine diphosphate or thrombin demonstrates a significant block in their ability to bind fibrinogen. The impairment of in vivo thrombus formation and in vitro fibrinogen binding are more significant than might be expected from the observed platelet binding to VWF polymers over a small portion of the plasma membrane. Visualization of the receptor/ligand interaction and characterization of a severe antithrombotic phenotype provide a new understanding on the molecular basis of bleeding associated with the PT-VWD phenotype.

  10. Variable content of von Willebrand factor mutant monomer drives the phenotypic variability in a family with von Willebrand disease.

    PubMed

    Chen, Junmei; Hinckley, Jesse D; Haberichter, Sandra; Jacobi, Paula; Montgomery, Robert; Flood, Veronica H; Wong, Randall; Interlandi, Gianluca; Chung, Dominic W; López, José A; Di Paola, Jorge

    2015-07-09

    Von Willebrand disease (VWD) is an inherited bleeding disorder characterized by incomplete penetrance and variable expressivity. We evaluated a 24-member pedigree with VWD type 2 caused by a T>G mutation at position 3911 that predicts a methionine to arginine (M1304R) change in the platelet-binding A1 domain of von Willebrand factor (VWF). This mutation manifests as an autosomal-dominant trait, with clinical and biochemical phenotypic variability among affected individuals, including differences in bleeding tendency and VWF quantity, activity, and multimer pattern. Sequencing of all VWF coding regions in 3 affected individuals did not identify additional mutations. When expressed in heterologous cells, M1304R was secreted in lower quantities, failed to drive formation of storage granules, and was defective in multimerization and platelet binding. When cotransfected in equal quantities with the wild-type complementary DNA, the mutant complementary DNA depressed VWF secretion, although multimerization was only mildly affected. A llama nanobody (AU/VWFa-11) that detects the mutant A1 domain demonstrated highly variable binding to VWF from different affected members, indicating that the VWF contained different percentages of mutant monomers in different individuals. Thus, the observed variability in VWD phenotypes could in part be determined by the extent of mutant monomer incorporation in the final multimer structure of plasma VWF.

  11. Platelet-independent adhesion of calcium-loaded erythrocytes to von Willebrand factor

    PubMed Central

    Bierings, Ruben; Meems, Henriet; Mul, Frederik P. J.; Geerts, Dirk; Vlaar, Alexander P. J.; Voorberg, Jan; Hordijk, Peter L.

    2017-01-01

    Adhesion of erythrocytes to endothelial cells lining the vascular wall can cause vaso-occlusive events that impair blood flow which in turn may result in ischemia and tissue damage. Adhesion of erythrocytes to vascular endothelial cells has been described in multiple hemolytic disorders, especially in sickle cell disease, but the adhesion of normal erythrocytes to endothelial cells has hardly been described. It was shown that calcium-loaded erythrocytes can adhere to endothelial cells. Because sickle erythrocyte adhesion to ECs can be enhanced by ultra-large von Willebrand factor multimers, we investigated whether calcium loading of erythrocytes could promote binding to endothelial cells via ultra-large von Willebrand factor multimers. We used (immunofluorescent) live-cell imaging of washed erythrocytes perfused over primary endothelial cells at venular flow rate. Using this approach, we show that calcium-loaded erythrocytes strongly adhere to histamine-stimulated primary human endothelial cells. This adhesion is mediated by ultra-large von Willebrand factor multimers. Von Willebrand factor knockdown or ADAMTS13 cleavage abolished the binding of erythrocytes to activated endothelial cells under flow. Platelet depletion did not interfere with erythrocyte binding to von Willebrand factor. Our results reveal platelet-independent adhesion of calcium-loaded erythrocytes to endothelium-derived von Willebrand factor. Erythrocyte adhesion to von Willebrand factor may be particularly relevant for venous thrombosis, which is characterized by the formation of erythrocyte-rich thrombi. PMID:28249049

  12. Is the activated partial thromboplastin time suitable to screen for von Willebrand factor deficiencies?

    PubMed

    Lippi, Giuseppe; Franchini, Massimo; Poli, Giovanni; Salvagno, Gian Luca; Montagnana, Martina; Guidi, Gian Cesare

    2007-06-01

    The diagnostic approach to von Willebrand factor deficiencies is challenging and requires discretionary use of laboratory resources. Although extensive preoperative testing is not recommended, the activated partial thromboplastin time may be useful, especially in selected categories of patients. To establish the diagnostic sensitivity of this test to identify isolate von Willebrand factor deficiencies, 204 consecutive patients underwent a routine preoperative screening consisting of activated partial thromboplastin time, von Willebrand factor antigen, intrinsic pathway clotting factors activity, lupus anticoagulants and thrombin time. Thirty-seven patients were diagnosed with haemostasis disturbances other than von Willebrand factor deficiencies and were excluded from the evaluation. Isolated von Willebrand factor deficiency was diagnosed in 11 of the remaining 167 patients. A significant correlation was observed between von Willebrand factor antigen and activated partial thromboplastin time. Receiver operating characteristic curve analysis showed an area under the curve of 0.982 (95% confidence interval: 0.972-0.992; P < 0.001). At the 1.17 upper limit of the activated partial thromboplastin time, sensitivity and specificity were 100 and 85%, respectively, with negative and positive predictive values of 100 and 31%, respectively. These results demonstrate that activated partial thromboplastin time has an excellent diagnostic sensitivity and a satisfactory specificity for identifying isolated von Willebrand factor deficiencies.

  13. von Willebrand factor binds to the surface of dendritic cells and modulates peptide presentation of factor VIII

    PubMed Central

    Sorvillo, Nicoletta; Hartholt, Robin B.; Bloem, Esther; Sedek, Magdalena; Brinke, Anja ten; van der Zwaan, Carmen; van Alphen, Floris P.; Meijer, Alexander B.; Voorberg, Jan

    2016-01-01

    It has been proposed that von Willebrand factor might affect factor VIII immunogenicity by reducing factor VIII uptake by antigen presenting cells. Here we investigate the interaction of recombinant von Willebrand factor with immature monocyte-derived dendritic cells using flow cytometry and confocal microscopy. Surprisingly, von Willebrand factor was not internalized by immature dendritic cells, but remained bound to the cell surface. As von Willebrand factor reduces the uptake of factor VIII, we investigated the repertoire of factor VIII presented peptides when in complex with von Willebrand factor. Interestingly, factor VIII-derived peptides were still abundantly presented on major histocompatibility complex class II molecules, even though a reduction of factor VIII uptake by immature dendritic cells was observed. Inspection of peptide profiles from 5 different donors showed that different core factor VIII peptide sequences were presented upon incubation with factor VIII/von Willebrand factor complex when compared to factor VIII alone. No von Willebrand factor peptides were detected when immature dendritic cells were pulsed with different concentrations of von Willebrand factor, confirming lack of von Willebrand factor endocytosis. Several von Willebrand factor derived peptides were recovered when cells were pulsed with von Willebrand factor/factor VIII complex, suggesting that factor VIII promotes endocytosis of small amounts of von Willebrand factor by immature dendritic cells. Taken together, our results establish that von Willebrand factor is poorly internalized by immature dendritic cells. We also show that von Willebrand factor modulates the internalization and presentation of factor VIII-derived peptides on major histocompatibility complex class II. PMID:26635035

  14. [Ernst von der Porten : looking for facts before and after forced emigration].

    PubMed

    Goerig, M; Bruijn, L

    2014-10-01

    The Ernst von der Porten medal has been awarded for many years to exceptional personalities by the Alliance of German Anesthesiologists to honor the outstanding achievements of the physician Ernst von der Porten from Hamburg in the development of anesthesiology as an autonomous discipline Only recent access to hitherto inaccessible documents enabled the reconstruction of his final years. He was persecuted and excluded by the National Socialist (NS) regime due to his Jewish roots and finally forced to emigrate. Records revealed that even in the so-called safe exile, degrading treatment and humiliation continued for Ernst von der Porten and his family. He eventually evaded this situation by committing suicide.

  15. Alexander von Humboldt's perceptions of colonial Spanish America.

    PubMed

    Rebok, Sandra

    2009-01-01

    This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind.

  16. The role of von Willebrand factor in thrombus formation.

    PubMed

    Ruggeri, Zaverio M

    2007-01-01

    Von Willebrand factor (VWF) is a large multimeric glycoprotein produced in endothelial cells and megakaryocytes and present in subendothelial matrix, blood plasma and platelets. VWF mediates adhesion and aggregation of platelets at sites of vascular injury, processes that are critical for both haemostasis and thrombosis. Thrombus formation involves complex events that are influenced by different environmental conditions. Progress in understanding the structure and function of VWF and the mechanisms that underlie its interactions with platelets has led to important insight into the differentiation between normal haemostasis and pathological arterial thrombosis. The conventional view of signalling-induced platelet aggregation has recently been extended to include activation-independent aggregation. A novel mechanism has been demonstrated for initiating thrombus formation under high haemodynamic forces that involves alpha(IIb)beta(3)-independent platelet aggregation at the interface between immobilised and soluble VWF. This VWF-mediated process may be a key determinant of platelet accumulation in stenotic arteries leading to acute thrombotic occlusion.

  17. A Powerful Friendship: Theodore von Karman and Hugh L. Dryden

    NASA Technical Reports Server (NTRS)

    Gorn, Michael

    2003-01-01

    During their long personal friendship and professional association, Theodore von Karman (1882-1963) and Hugh L. Dryden (1898-1965) exercised a pivotal if somewhat elusive influence over American aeronautics and spaceflight. Both decisive figures in organizing scientists and engineers at home and abroad, both men of undisputed eminence in their technical fields, their range of contacts in government, academia, the armed forces, industry, and professional societies spanned the globe to an extent unparalleled then as now. Moreover, because they coordinated their activities closely, their combined influence far exceeded the sum of each one s individual contributions. This paper illustrates their personal origins as well as the foundations of their friendship, how their relationship became a professional alliance, and their joint impact on the world of aeronautics and astronautics during the twentieth century.

  18. Using genetic diagnostics in hemophilia and von Willebrand disease.

    PubMed

    Swystun, Laura L; James, Paula

    2015-01-01

    Most bleeding disorders encountered in clinical practice will be diagnosed, at least initially, by phenotypic assays. However, since the characterization of the genes that encode coagulation factors in the 1980s, significant progress has been made in translating this knowledge for diagnostic and therapeutic purposes. For hemophilia A and B, molecular genetic testing to determine carrier status, prenatal diagnosis, and likelihood of inhibitor development or anaphylaxis to infused coagulation factor concentrates is an established component of comprehensive clinical management. In contrast, although significant recent advances in our understanding of the molecular genetic basis of von Willebrand disease (VWD) have allowed for the development of rational approaches to genetic diagnostics, questions remain about this complex genetic disorder and how to incorporate emerging knowledge into diagnostic strategies. This article will review the state-of-the-art for molecular diagnostics for both hemophilia and VWD.

  19. Voluntarism in early psychology: the case of Hermann von Helmholtz.

    PubMed

    De Kock, Liesbet

    2014-05-01

    The failure to recognize the programmatic similarity between (post-)Kantian German philosophy and early psychology has impoverished psychology's historical self-understanding to a great extent. This article aims to contribute to recent efforts to overcome the gaps in the historiography of contemporary psychology, which are the result of an empiricist bias. To this end, we present an analysis of the way in which Hermann von Helmholtz's theory of perception resonates with Johann Gottlieb Fichte's Ego-doctrine. It will be argued that this indebtedness is particularly clear when focusing on the foundation of the differential awareness of subject and object in perception. In doing so, the widespread reception of Helmholtz's work as proto-positivist or strictly empiricist is challenged, in favor of the claim that important elements of his theorizing can only be understood properly against the background of Fichte's Ego-doctrine.

  20. Von Glaserfeld`s Radical Constructivism: A Critical Review

    NASA Astrophysics Data System (ADS)

    Hardy, Michael D.

    We explore Ernst von Glaserfelds radical constructivism, its criticisms, and our own thoughts on what it promises for the reform of science and mathematics teaching. Our investigation reveals that many criticisms of radical constructivism are unwarranted; nevertheless, in its current cognitivist form radical constructivism may be insufficient to empower teachers to overcome objectivist cultural traditions. Teachers need to be empowered with rich understandings of philosophies of science and mathematics that endorse relativist epistemologies; for without such they are unlikely to be prepared to reconstruct their pedagogical practices. More importantly, however, is a need for a powerful social epistemology to serve as a referent for regenerating the culture of science education. We recommend blending radical constructivism with Habermas theory of communicative action to provide science teachers with a moral imperative for adopting a constructivist epistemology.

  1. ADAMTS13 and von Willebrand factor in thrombotic thrombocytopenic purpura.

    PubMed

    Zheng, X Long

    2015-01-01

    Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular injury. Deficiency of plasma ADAMTS13 activity (<10%) resulting from mutations of the ADAMTS13 gene or autoantibodies against ADAMTS13 causes hereditary or acquired (idiopathic) TTP. ADAMTS13 activity is usually normal or modestly reduced (>20%) in other forms of thrombotic microangiopathy secondary to hematopoietic progenitor cell transplantation, infection, and disseminated malignancy or in hemolytic uremic syndrome. Plasma infusion or exchange remains the initial treatment of choice to date, but novel therapeutics such as recombinant ADAMTS13 and gene therapy are under development. Moreover, ADAMTS13 deficiency has been shown to be a risk factor for the development of myocardial infarction, stroke, cerebral malaria, and preeclampsia.

  2. Notes on a General Framework for Observed Score Equating. Research Report. ETS RR-08-59

    ERIC Educational Resources Information Center

    Moses, Tim; Holland, Paul

    2008-01-01

    The purpose of this paper is to extend von Davier, Holland, and Thayer's (2004b) framework of kernel equating so that it can incorporate raw data and traditional equipercentile equating methods. One result of this more general framework is that previous equating methodology research can be viewed more comprehensively. Another result is that the…

  3. Closed and Open Systems: The Tavistock Group from a General System Perspective.

    ERIC Educational Resources Information Center

    Rugel, Robert P.

    1991-01-01

    Describes phases in the life of a Tavistock group composed of college students using concepts from Von Bertalanffy's general systems theory, MacKenzie's role theory, and Kantor's family theory. Discusses early, middle, and late phases of typical 16-session group as it moves from a closed to an open system. (Author/NB)

  4. Fitting the Structured General Diagnostic Model to NAEP Data. Research Report. ETS RR-08-27

    ERIC Educational Resources Information Center

    Xu, Xueli; von Davier, Matthias

    2008-01-01

    Xu and von Davier (2006) demonstrated the feasibility of using the general diagnostic model (GDM) to analyze National Assessment of Educational Progress (NAEP) proficiency data. Their work showed that the GDM analysis not only led to conclusions for gender and race groups similar to those published in the NAEP Report Card, but also allowed…

  5. Terminal platelet production is regulated by von Willebrand factor.

    PubMed

    Poirault-Chassac, Sonia; Nguyen, Kim Anh; Pietrzyk, Audrey; Casari, Caterina; Veyradier, Agnes; Denis, Cecile V; Baruch, Dominique

    2013-01-01

    It is established that proplatelets are formed from mature megakaryocytes (MK) as intermediates before platelet production. Recently, the presence of proplatelets was described in blood incubated in static conditions. We have previously demonstrated that platelet and proplatelet formation is upregulated by MK exposure to high shear rates (1800 s(-1)) on immobilized von Willebrand factor (VWF). The purpose of the present study was to investigate whether VWF is involved in the regulation of terminal platelet production in blood. To this end, Vwf (-/-) mice, a model of severe von Willebrand disease, were used to create a situation in which blood cells circulate in a vascular tree that is completely devoid of VWF. Murine platelets were isolated from Vwf (-/-) and Vwf (+/+) blood, exposed to VWF at 1800 s(-1) in a microfluidic platform, and examined by means of videomicroscopy, as well as fluorescence and activation studies. Proplatelets became visible within 5 minutes, representing 38% of all platelets after 12 minutes and 46% after 28 min. The proportion of proplatelets was 1.8-fold higher in blood from Vwf(-/-) mice than from Vwf(+/+) mice, suggesting a role of VWF in vivo. Fragmentation of these proplatelets into smaller discoid platelets was also observed in real-time. Platelets remained fully activatable by thrombin. Compensation of plasmatic VWF following hydrodynamic gene transfer in Vwf(-/-) mice reduced the percentage of proplatelets to wild-type levels. A thrombocytopenic mouse model was studied in the flow system, 7 days after a single 5-FU injection. Compared to untreated mouse blood, a 2-fold increase in the percentage of proplatelets was detected following exposure to 1800 s(-1) on VWF of samples from mice treated with 5-FU. In conclusion, VWF and shear stress together appear to upregulate proplatelet reorganization and platelet formation. This suggests a new function for VWF in vivo as regulator of bloodstream thrombopoiesis.

  6. [Reference relationships between human and animal in Hildegard von Bingen].

    PubMed

    Riethe, Peter

    2012-01-01

    In "De animalibus", the 7th book in the "Liber simplicis medicinae", Hildegard von Bingen describes the characteristics of four-footed land animals. Some of these have a special relationship with humans in that they embody moral qualities. An explanation for this is already given in the preface, which states that human intelligence recognizes these qualities, declaring that "You are this or that sort of creature". Since the relationship that animals have with nature shares a degree of similarity with that of man's, they can be regarded as symbolic representatives for particular human traits and characteristics. The article at hand presents Hildegard von Bingen's descriptions of the monkey, the lion, the bear, the rabbit, the dog, the cat, the wolf, the lynx, and the donkey. While the monkey just mimics man's behaviour and is imperfect in both settings, the lion embodies will power. The bear on the other hand stands for unbridled sexual desire, while in the rabbit the gentleness of a sheep is united with the bounce of a deer. The lynx is regarded as hedonistic, the donkey as stupid, and the wolf as surrounded by dangerous sylphs. In Hildegard's depictions, exotic and native animal species display rather extraordinary behavioural traits, and the medieval Christian world view of the author conveys unexpected relationships between humans and animals. In addition to empirical observation and experience, Hildegard also relies on folkloristic beliefs and magical practices related to explanatory models of her time. She allows largely unknown sources into her animal lore but never strays from her ultimate goal of having it serve to instruct people. In doing so, Hildegard removed herself far from the common tradition of medieval animal portraits.

  7. Acquired von Willebrand syndrome in children with aorticand pulmonary stenosis

    PubMed Central

    Binnetoğlu, Fatih Köksal; Babaoğlu, Kadir; Filiz, Şayegan Güven; Zengin, Emine; Sarper, Nazan; Altun, Gürkan; Kılıç, Suar Çakı

    2016-01-01

    Summary Introduction: This prospective study was planned to investigate the frequency and relationship of acquired von Willebrand syndrome (AVWS) with aortic and pulmonary stenosis in patients. Methods: A total of 84 children, ranging from two to 18 years of age, were enrolled in this study. Of these, 28 had isolated aortic stenosis, 32 had isolated pulmonary stenosis and 24 were healthy. Children with aortic and pulmonary stenosis associated with other congenital heart diseases were excluded. Children with hypothyroidism, renal or liver disease, malignancy or autoimmune disease were also excluded. Wholeblood count, blood group, factor VIII level, prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor antigen (VWF:Ag), ristocetin co-factor (VWF:RCo), and bleeding time using a platelet-function analyser (PFA-100) were performed in all patients. All of the children in the study underwent a detailed physical examination and echocardiographic evaluation. Results: A history of bleeding was positive in 18% of the aortic stenosis group, 9% of the pulmonary stenosis group, and 4% of the control group. Seven of 60 (12%) patients had laboratory findings that implied a diagnosis of AVWS, and two of these (28%) had a history of bleeding. The frequency of AVWS was 14% in patients with aortic stenosis and 9% in those with pulmonary stenosis. Conclusion: AVWS is not rare in stenotic obstructive cardiac diseases. A detailed history of bleeding should be taken from patients with valvular disease. Even if the history is negative, whole blood count, PT and aPTT should be performed. If necessary, PFA-100 closure time and further tests should be planned for the diagnosis of AVWS. PMID:27841910

  8. Dynamics of Diffusion Flames in von Karman Swirling Flows Studied

    NASA Technical Reports Server (NTRS)

    Nayagam, Vedha; Williams, Forman A.

    2002-01-01

    Von Karman swirling flow is generated by the viscous pumping action of a solid disk spinning in a quiescent fluid media. When this spinning disk is ignited in an oxidizing environment, a flat diffusion flame is established adjacent to the disk, embedded in the boundary layer (see the preceding illustration). For this geometry, the conservation equations reduce to a system of ordinary differential equations, enabling researchers to carry out detailed theoretical models to study the effects of varying strain on the dynamics of diffusion flames. Experimentally, the spinning disk burner provides an ideal configuration to precisely control the strain rates over a wide range. Our original motivation at the NASA Glenn Research Center to study these flames arose from a need to understand the flammability characteristics of solid fuels in microgravity where slow, subbuoyant flows can exist, producing very small strain rates. In a recent work (ref. 1), we showed that the flammability boundaries are wider and the minimum oxygen index (below which flames cannot be sustained) is lower for the von Karman flow configuration in comparison to a stagnation-point flow. Adding a small forced convection to the swirling flow pushes the flame into regions of higher strain and, thereby, decreases the range of flammable strain rates. Experiments using downward facing, polymethylmethacrylate (PMMA) disks spinning in air revealed that, close to the extinction boundaries, the flat diffusion flame breaks up into rotating spiral flames (refs. 2 and 3). Remarkably, the dynamics of these spiral flame edges exhibit a number of similarities to spirals observed in biological systems, such as the electric pulses in cardiac muscles and the aggregation of slime-mold amoeba. The tail of the spiral rotates rigidly while the tip executes a compound, meandering motion sometimes observed in Belousov-Zhabotinskii reactions.

  9. John von Neumann and Klaus Fuchs: an Unlikely Collaboration

    NASA Astrophysics Data System (ADS)

    Bernstein, Jeremy

    2010-03-01

    I discuss the origin of the idea of making a fusion (hydrogen) bomb and the physics involved in it, and then turn to the design proposed for one by the unlikely collaborators John von Neumann and Klaus Fuchs in a patent application they filed at Los Alamos in May 1946, which Fuchs passed on to the Russians in March 1948, and which with substantial modifications was tested on the island of Eberiru on the Eniwetok atoll in the South Pacific on May 8, 1951. This test showed that the fusion of deuterium and tritium nuclei could be ignited, but that the ignition would not propagate because the heat produced was rapidly radiated away. Meanwhile, Stanislaw Ulam and C.J. Everett had shown that Edward Teller’s Classical Super could not work, and at the end of December 1950, Ulam had conceived the idea of super compression, using the energy of a fission bomb to compress the fusion fuel to such a high density that it would be opaque to the radiation produced. Once Teller understood this, he invented a greatly improved, new method of compression using radiation, which then became the heart of the Ulam-Teller bomb design, which was tested, also in the South Pacific, on November 1, 1952. The Russians have freely acknowledged that Fuchs gave them the fission bomb, but they have insisted that no one gave them the fusion bomb, which grew out of design involving a fission bomb surrounded by alternating layers of fusion and fission fuels, and which they tested on November 22, 1955. Part of the irony of this story is that neither the American nor the Russian hydrogen-bomb programs made any use of the brilliant design that von Neumann and Fuchs had conceived as early as 1946, which could have changed the entire course of development of both programs.

  10. Dynamical Correspondence in a Generalized Quantum Theory

    NASA Astrophysics Data System (ADS)

    Niestegge, Gerd

    2015-05-01

    In order to figure out why quantum physics needs the complex Hilbert space, many attempts have been made to distinguish the C*-algebras and von Neumann algebras in more general classes of abstractly defined Jordan algebras (JB- and JBW-algebras). One particularly important distinguishing property was identified by Alfsen and Shultz and is the existence of a dynamical correspondence. It reproduces the dual role of the selfadjoint operators as observables and generators of dynamical groups in quantum mechanics. In the paper, this concept is extended to another class of nonassociative algebras, arising from recent studies of the quantum logics with a conditional probability calculus and particularly of those that rule out third-order interference. The conditional probability calculus is a mathematical model of the Lüders-von Neumann quantum measurement process, and third-order interference is a property of the conditional probabilities which was discovered by Sorkin (Mod Phys Lett A 9:3119-3127, 1994) and which is ruled out by quantum mechanics. It is shown then that the postulates that a dynamical correspondence exists and that the square of any algebra element is positive still characterize, in the class considered, those algebras that emerge from the selfadjoint parts of C*-algebras equipped with the Jordan product. Within this class, the two postulates thus result in ordinary quantum mechanics using the complex Hilbert space or, vice versa, a genuine generalization of quantum theory must omit at least one of them.

  11. General Conformity

    EPA Pesticide Factsheets

    The General Conformity requirements ensure that the actions taken by federal agencies in nonattainment and maintenance areas do not interfere with a state’s plans to meet national standards for air quality.

  12. General paresis

    MedlinePlus

    ... due to damage to the brain from untreated syphilis. Causes General paresis is one form of neurosyphilis . ... usually occurs in people who have had untreated syphilis for many years. Syphilis is bacterial infection that ...

  13. General Dentist

    MedlinePlus

    ... information you need from the Academy of General Dentistry Sunday, April 9, 2017 About | Contact InfoBites Quick ... Instead of specializing in just one area of dentistry, they can provide plenty of different services for ...

  14. Molecular evolution of the nuclear von Willebrand factor gene in mammals and the phylogeny of rodents.

    PubMed

    Huchon, D; Catzeflis, F M; Douzery, E J

    1999-05-01

    Nucleotide sequences of exon 28 of the von Willebrand Factor (vWF) were analyzed for a representative sampling of rodent families and eutherian orders, with one marsupial sequence as outgroup. The aim of this study was to test if inclusion of an increased taxonomic diversity in molecular analyses would shed light on three uncertainties concerning rodent phylogeny: (1) relationships between rodent families, (2) Rodentia monophyly, and (3) the sister group relationship of rodents and lagomorphs. The results did not give evidence of any particular rodent pattern of molecular evolution relative to a general eutherian pattern. Base compositions and rates of evolution of vWF sequences of rodents were in the range of placental variation. The 10 rodent families studied here cluster in five clades: Hystricognathi, Sciuridae and Aplodontidae (Sciuroidea), Muridae, Dipodidae, and Gliridae. Among hystricognaths, the following conclusions are drawn: a single colonization event in South America by Caviomorpha, a paraphyly of Old World and New World porcupines, and an African origin for Old World porcupines. Despite a broader taxonomic sampling diversity, we did not obtain a robust answer to the question of Rodentia monophyly, but in the absence of any other alternative, we cannot reject the hypothesis of a single origin of rodents. Moreover, the phylogenetic position of Lagomorpha remains totally unsettled.

  15. From Wilhelm von Humboldt to Hitler-are prominent people more prone to have Parkinson's disease?

    PubMed

    Horowski; Horowski; Calne; Calne

    2000-10-01

    We describe Parkinsonism in prominent people, where Wilhelm von Humboldt and Adolf Hitler provide just two spectacular, opposing examples. In both of them, there is little if any evidence that the disease did influence their life ambitions, methods of achieving them or cognitive function in general. Thus, Hitler's Parkinsonism should remain a 'footnote' to history, and historians should acknowledge that in his last years, his trembling, his curbed posture, his slow walking, mask-like face and low voice did not indicate remorse, fear or depression as a consequence of his crimes, but were mere expressions of his disease which, until the end, had no impact on his intellectual skills and methods. The apparently higher incidence of Parkinsonism in prominent people may be just due to their higher visibility, or a consequence of disease-related personality traits (e.g. ambition, perfectionism, rigidity) which may contribute to becoming, e.g., a prominent authoritarian person. Perhaps even some early behaviour pattern (such as repressed emotions or acting in public-which could even increase the risk of some infection) contributes to a greater vulnerability for developing Parkinsonism. Further studying other prominent cases might lead us to better understanding of risk factors and the expression of early Parkinsonism.

  16. Postpartum von Willebrand factor levels in women with and without von Willebrand disease and implications for prophylaxis.

    PubMed

    James, A H; Konkle, B A; Kouides, P; Ragni, M V; Thames, B; Gupta, S; Sood, S; Fletcher, S K; Philipp, C S

    2015-01-01

    The aim of this study was to elucidate the fall in von Willebrand factor (VWF) and factor VIII activity (FVIII) after childbirth in women with and without von Willebrand disease (VWD). VWF:RCo, VWF:Ag, and FVIII were obtained in the third trimester of pregnancy, on admission for childbirth, and 10 times postpartum. Specimens were processed within 4 h and analysed centrally. Means were calculated at each time point. Forty women (40 pregnancies) without VWD and 32 women (35 pregnancies) with VWD were enrolled. 15/32 with VWD were treated (30% of those with type 1 and all of those with type 2) in 17 pregnancies. Treatments prior to delivery consisted of desmopressin (2/17), VWF concentrate (15/17) and after delivery VWF concentrate (16/17). Duration of treatment was 0-21 days (median 6). VWF levels peaked at 250% of baseline--4 h postpartum in women with VWD and 12 h postpartum in women without VWD. Thereafter, VWF levels fell rapidly, approached baseline at 1 week and reached baseline at 3 weeks. Except immediately postpartum, when the levels among treated cases were higher, levels among women with VWD appeared to parallel, but were lower than those among women without VWD. Levels were lowest among those who received treatment. VWF levels fall rapidly after childbirth. Except immediately postpartum, current treatment strategies do not raise VWF levels to the levels of women without VWD or even to the levels of women with milder, untreated VWD. Consequently, women with VWD may be at risk of postpartum haemorrhage despite treatment.

  17. Diagnostic Differentiation of von Willebrand Disease Types 1 and 2 by von Willebrand Factor Multimer Analysis and DDAVP Challenge Test.

    PubMed

    Michiels, Jan Jacques; Smejkal, Petr; Penka, Miroslav; Batorova, Angelika; Pricangova, Tatiana; Budde, Ulrich; Vangenechten, Inge; Gadisseur, Alain

    2016-01-01

    The European Clinical Laboratory and Molecular (ECLM) classification of von Willebrand disease (vWD) is based on the splitting approach which uses sensitive and specific von Willebrand factor (vWF) assays with regard to the updated molecular data on structure and function of vWF gene and protein defects. A complete set of FVIII:C and vWF ristocetine cofactor, collagen binding, and antigen, vWF multimeric analysis in low- and medium-resolution gels, and responses to desmopressin (DDAVP) of FVIII:C and vWF parameters are mandatory. The ECLM classification distinguishes recessive types 1 and 3 vWD from recessive vWD 2C due to mutations in the D1 and D2 domains and vWD 2N due to mutations in the D'-FVIII-binding domain of vWF. The ECLM classification differentiates between mild vWD type 1 with variable penetrance of bleedings from symptomatic dominant type 1 vWD secretion defect and/or clearance defect with normal vWF multimers versus vWD 1M and 2M with normal or smeary vWF multimers in low- and medium-resolution gels. High-quality multimeric analysis of vWF in medium-resolution gels based on a DDAVP challenge test clearly delineates and distinguishes each of the dominant type 2 vWDs 1/2E, 2M, 2B, 2A, and 2D caused by vWF gene mutations in the D3 multimerization domain, loss or gain-of-function mutations in the glycoprotein Ib receptor A1 domain, gene mutations in the A2 proteolytic domain, and the C-terminal dimerization domain, respectively.

  18. Markov property and strong additivity of von Neumann entropy for graded quantum systems

    SciTech Connect

    Moriya, Hajime

    2006-03-15

    The quantum Markov property is equivalent to the strong additivity of von Neumann entropy for graded quantum systems. The additivity of von Neumann entropy for bipartite graded systems implies the statistical independence of states. However, the structure of Markov states for graded systems is different from that for tensor-product systems which have trivial grading. For three-composed graded systems we have U(1)-gauge invariant Markov states whose restriction to the marginal pair of subsystems is nonseparable.

  19. von Neumann measurement-related matrices and the nullity condition for quantum correlation

    NASA Astrophysics Data System (ADS)

    Zhao, MingJing; Ma, Teng; Zhang, TingGui; Fei, Shao-Ming

    2016-12-01

    We study von Neumann measurement-related matrices, and the nullity condition of quantum correlation. We investigate the properties of these matrices that are related to a von Neumann measurement. It is shown that these ( m 2 - 1) × ( m 2 - 1) matrices are idempotent, and have rank m - 1. These properties give rise to necessary conditions for the nullity of quantum correlations in bipartite systems. Finally, as an example we discuss quantum correlation in Bell diagonal states.

  20. Fibroblast growth factor-10 signals development of von Brunn's nests in the exstrophic bladder.

    PubMed

    Eastman, Rocky; Leaf, Elizabeth M; Zhang, Dianzhong; True, Lawrence D; Sweet, Robert M; Seidel, Kristy; Siebert, Joseph R; Grady, Richard; Mitchell, Michael E; Bassuk, James A

    2010-11-01

    von Brunn's nests have long been recognized as precursors of benign lesions of the urinary bladder mucosa. We report here that von Brunn's nests are especially prevalent in the exstrophic bladder, a birth defect that predisposes the patient to formation of bladder cancer. Cells of von Brunn's nest were found to coalesce into a stratified, polarized epithelium which surrounds itself with a capsule-like structure rich in types I, III, and IV collagen. Histocytochemical analysis and keratin profiling demonstrated that nested cells exhibited a phenotype similar, but not identical, to that of urothelial cells of transitional epithelium. Immunostaining and in situ hybridization analysis of exstrophic tissue demonstrated that the FGF-10 receptor is synthesized and retained by cells of von Brunn's nest. In contrast, FGF-10 is synthesized and secreted by mesenchymal fibroblasts via a paracrine pathway that targets basal epithelial cells of von Brunn's nests. Small clusters of 10pRp cells, positive for both FGF-10 and its receptor, were observed both proximal to and inside blood vessels in the lamina propria. The collective evidence points to a mechanism where von Brunn's nests develop under the control of the FGF-10 signal transduction system and suggests that 10pRp cells may be the original source of nested cells.

  1. Molecular and cellular biology of von Willebrand factor.

    PubMed

    Denis, Cécile V

    2002-01-01

    von Willebrand factor (VWF) is a plasma protein that performs 2 main functions in hemostasis: it mediates platelet adhesion to the injured vessel wall, and it carries and protects coagulation factor VIII. VWF is synthesized through a multistep process in endothelial cells and megakaryocytes as a very large polymer composed of identical disulfide-linked 250-kd subunits. In endothelial cells, VWF not only directs the formation of its own storage granules, the Weibel-Palade bodies, but it also acts as a chaperone molecule to direct other proteins, such as P-selectin, into these granules. Upon stimulation of the endothelium, the Weibel-Palade bodies will be translocated to the plasma membrane, and their contents will be secreted into the plasma milieu. The expression of VWF can be regulated at different levels by a number of genetic and environmental factors, resulting in control of its activity. New roles for VWF, especially in inflammatory processes, have recently been suggested, indicating that some aspects of this well-studied protein remain to be investigated.

  2. Characterization of the mouse von Willebrand factor promoter.

    PubMed

    Guan, J; Guillot, P V; Aird, W C

    1999-11-15

    Expression of the von Willebrand factor (vWF) gene is restricted to the endothelial and megakaryocyte lineages. Within the endothelium, expression of vWF varies between different vascular beds. We have previously shown that the human vWF promoter spanning a region between -2182 (relative to the start site of transcription) and the end of the first intron contains information for environmentally responsive, vascular bed-specific expression in the heart, skeletal muscle, and brain. In the present study, we cloned the mouse vWF (mvWF) promoter and studied its function in cultured endothelial cells and transgenic mice. In transient transfection assays, the mvWF gene was found to be regulated by distinct mechanisms in different endothelial cell subtypes. In independent lines of transgenic mice, an mvWF promoter fragment containing DNA sequences between -2645 and the end of the first intron directed endothelial cell-specific expression in the microvascular beds of the heart, brain, and skeletal muscle as well as the endothelial lining of the aorta. In 1 line of mice, reporter gene activity was also detected in bone marrow megakaryocytes. Taken together, these findings suggest that both the mouse and human vWF promoters are regulated by vascular bed-specific mechanisms.

  3. Functional property of von Willebrand factor under flowing blood.

    PubMed

    Sugimoto, Mitsuhiko; Miyata, Shigeki

    2002-01-01

    von Willebrand factor (vWF) is produced in megakaryocytes and endothelial cells, is stored in the alpha-granule of platelets and in the Weibel-Palade body of endothelial cells, and is present in plasma and vascular subendothelium. This huge protein with a unique multimeric structure plays a pivotal role in both hemostasis and pathological intravascular thrombosis, in which vWF contributes to both platelet adhesion/aggregation and blood coagulation through its multiple adhesive functions for the platelet membrane receptors, glycoprotein Ib-IX-V complex, integrin alphaIIbbeta3, heparin, various types of collagen, and coagulation factor VIII. Among various functions, the most characteristic feature of vWF is its determinant role on platelet thrombus formation under high-shear-rate conditions. Indeed, at in vivo rheological situations where platelets are flowing with high speed in the bloodstream, the only reaction that can initiate mural thrombogenesis is the interaction of vWF with platelet glycoprotein Ibalpha. The recent x-ray analysis of the crystal structure of various functional domains and functional studies of this protein under experimental flow conditions have rapidly advanced and revised our knowledge of the structure-function relationships of vWF, a key protein for hemostasis and arterial thrombosis.

  4. Ludwig von Bertalanffy's Organismic View on the Theory of Evolution

    PubMed Central

    Drack, Manfred

    2015-01-01

    Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 77–90, 2015. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals, Inc. PMID:25727202

  5. THE FINE STRUCTURE OF VON EBNER'S GLAND OF THE RAT

    PubMed Central

    Hand, Arthur R.

    1970-01-01

    The fine structure of von Ebner's gland was studied in untreated rats and rats stimulated to secrete by fasting-refeeding or injection of pilocarpine. Cytological features were similar to those reported for pancreas and parotid gland. Abundant granular endoplasmic reticulum filled the basal portion of the cell, a well-developed Golgi complex was located in the vicinity of the nucleus, and the apical portion of the cell was filled with dense secretory granules. Dense heterogeneous bodies resembling lysosomes were closely associated with the Golgi complex. Coated vesicles were seen in the Golgi region and also in continuity with the cell membrane. Granule discharge occurred by fusion of the granule membrane with the cell membrane at the secretory surface. Successive fusion of adjacent granules to the previously fused granule formed a connected string of granules in the apical cytoplasm. Myoepithelial cells were present within the basement membrane, and nerve processes were seen adjacent to acinar and myoepithelial cells. Duct cells resembled the intercalated duct cells of the major salivary glands. PMID:5411078

  6. [Hans von Hattingberg between psychoanalysis and National Socialism].

    PubMed

    Keifenheim, Katharina Eva

    2011-01-01

    Hans von Hattingberg (1879-1944) worked as a neurologist and psychoanalyst in Munich and Berlin from about 1910 to 1944. He was a prolific writer, but met with increasing disapproval from Freud and his circle. An advocate of the union of different psychotherapeutic schools, he was initially a marginal figure in the professional field. With Hitler's rise to power his career prospered: He was offered the position of a lecturer for psychotherapy and became head of the research department at the "Göring Institute". He came to prominence with his writings on the "Neue deutsche Seelenheilkunde" despite the fact that this was never his preferred topic. The main themes of his publications were marriage, love and female emancipation. Those works contain only little of the standard Nazi ideology of the time. Not only was Hattingberg never a member of the NSDAP (the ruling party), but in some respects he could conceivably be considered a member of the resistance. The article outlines the most important stages of Hattingberg's life and focuses on the question of how he positioned himself after 1933, when it became vital for him to reconcile psychoanalysis and National Socialism.

  7. Emperor Ashoka: Did he suffer from von Recklinghausen's diseases?

    PubMed Central

    Wig, N. N.; Sharma, Sheetal

    2015-01-01

    Emperor Ashoka is widely regarded as one of the greatest rulers of India. This paper mainly deals with his medical condition as recorded in the Buddhist texts of Sri Lanka as well as in the Buddhist texts of North India and Nepal. These sources mention his skin disorder which is described as very rough and unpleasant to touch. He is also known to have episodes of loss of consciousness at various times in his life. One of the earliest representations of Ashoka, about 100 years after his death at one of the gates of Sanchi Stupa, shows Ashoka fainting when visiting the Bodhi tree and being held by his queens. In this sculpture, Emperor Ashoka is shown as a man of short height, large head and a paunchy abdomen. In this paper, it is speculated that Emperor Ashoka was probably suffering from von Recklinghausen disease (Neurofibromatosis Type 1), which could explain his skin condition, episodes of loss of consciousness (probably epilepsy) and other bodily deformities. PMID:25657467

  8. Von recklinghausen disease: one patient – various problems

    PubMed Central

    Miziołek, B; Brzezińska-Wcisło, L

    2016-01-01

    Abstract von Recklinghausen disease (vRD), more widely known as neurofibromatosis type 1, belongs to a group of genetic disorders and it is considered to be the most common genodermatosis. The disease has an autosomal dominant pattern of inheritance that involves mutations within the NF1 gene located on chromosome 17 in locus q11.2. The product of the NF1 gene is neurofibromin and the protein is well known to be a tumor suppressor factor. This counteracts possible overactivity of RAS (protein)/MAPK (mitogen-activated protein kinase) and RAS/PI3K/AKT/mTOR (phoshatydyloinositol-3-kinase/V-akt murine thy-moma viral oncogene homologue/mammalian target of rapamycin) signaling transduction pathways, preventing from uncontrolled cell proliferation and subsequent tumor formation. A loss of proper functioning of this protein leads to a development of vRD; however, a large variability in a phenotype of the disease and the onset of cutaneous findings, not necessarily in childhood, may provide a clinical diagnosis of the disease late in adulthood. We present a 52-year-old male in whom the diagnosis of vRD was proposed in the sixth decade of life, despite of multiple nodular lesions disseminated over the skin of the whole body and different neurological disturbances, not considered for a long time as manifestations of genodermatosis. PMID:27785414

  9. Magnetohydrodynamics measurements in the von Karman sodium experiment

    NASA Astrophysics Data System (ADS)

    Bourgoin, Mickael; Marie, Louis; Petrelis, Francois; Gasquet, Cecile; Guigon, Alain; Luciani, Jean-Baptiste; Moulin, Marc; Namer, Frederic; Burguete, Javier; Chiffaudel, Arnaud; Fauve, Stephan; Odier, Philippe

    2002-09-01

    We study the magnetic induction in a confined swirling flow of liquid sodium, at integral magnetic Reynolds numbers up to 50. More precisely, we measure in situ the magnetic field induced by the flow motion in the presence of a weak external field. Because of the very small value of the magnetic Prandtl number of all liquid metals, flows with even modest Rm are strongly turbulent. Large mean induction effects are observed over a fluctuating background. As expected from the von Karman flow geometry, the induction is strongly anisotropic. The main contributions are the generation of an azimuthal induced field when the applied field is in the axial direction (an Omega effect) and the generation of axial induced field when the applied field is the transverse direction (as in a large scale alpha effect). Strong fluctuations of the induced field, due to the flow nonstationarity, occur over time scales slower than the flow forcing frequency. In the spectral domain, they display a f-1 spectral slope. At smaller scales (and larger frequencies) the turbulent fluctuations are in agreement with a Kolmogorov modeling of passive vector dynamics.

  10. Modellbasierte Segmentierung von differenzierten Lymphknoten in CT-Daten

    NASA Astrophysics Data System (ADS)

    Dornheim, Lars; Dornheim, Jana

    Für die computerbasierte Diagnoseunterstützung bei Tumorerkrankungen ist Wissen über Lage, Ausdehnung und Art der Lymphknoten für die TNM-Klassifikation nötig. Für die computergestütze Planung nachfolgender Eingriffe wie der Hals-Lymphknoten-Ausräumung, ist dieses Wissen ebenfalls von Bedeutung. Deshalb ist ein effizientes und exaktes Segmentierungsverfahren für Lymphknoten in CT-Datensätzen erforderlich, das besonders auch mit pathologisch veränderten Lymphknoten zurechtkommt. Basierend auf früheren Arbeiten präsentieren wir in dieser Arbeit ein deutlich weiterentwickeltes, modellbasiertes Segmentierungsverfahren für Lymphknoten in CT-Datensätzen, mit dem nun besonders auch vergrößerte sowie nekrotische Lymphknoten adressiert werden. Unser Verfahren wurde an 21 Lymphknoten aus 5 CT-Datensätzen getestet, darunter mehrere vergrößerte und nekrotische. Die Ergebnisse liegen im Bereich der Inter-Personen-Varianz und verbessern die Ergebnisse früherer Arbeiten noch einmal spürbar.

  11. Bifurcation analysis of an infinite array of von Karman Streets

    NASA Astrophysics Data System (ADS)

    Ghaemi Oskouei, Babak; Kanso, Eva; Newton, Paul K.

    2008-11-01

    This research investigates the behavior of an infinite array of (inverse) von Karman streets. Primary motivation is to model the wake dynamics in large fish schools. Ignoring the fish we focus on the dynamic interaction of multiple wakes. In particular, we investigate the problem of fluid transport between adjacent vortex streets for its relevance to understanding the transport of oxygen and nutrients to inner fish in large schools as well as understanding flow barriers to passive locomotion. We prove that the configuration of vortices is in relative equilibrium, meaning that the streamline pattern remains steady in the frame moving with vortices. We look at the topology of these streamline patterns plotted in the moving frame which lends insight to fluid transport through the mid-wake region. Fluid is advected along different paths depending on the distance separating two adjacent streets. When the streets are far apart, the dynamics is decoupled and fluid is transported globally between two adjacent streets. When the streets get closer to each other, the number of streets that enter into partnership in transporting fluid among themselves increases. This observation motivates a bifurcation analysis which links the distance between streets to the maximum number of streets transporting fluid among themselves.

  12. Darwin the geologist: Between Lyell and von Buch.

    PubMed

    Gohau, Gabriel

    2010-02-01

    Upon returning from his voyage on the Beagle, Darwin prepared reports of his geological observations. Together, these reveal Darwin's approach to reasoning about geology. Darwin argued that successive terraces prove a very gradual elevation of the coast that lagoon islands show a reciprocal sinking of the oceanic floor. Hence, Darwin reinforced Lyell's uniformitarian, or steady state theory. Unlike lagoon islands, the movement of erratic boulders onto the plains is evidence of forces, which do not now exist. Darwin and Lyell attributed this movement to floating icebergs. However, mountain formation remained difficult for them to explain with reference to contemporary causes. Lyell discovered uplifts in Scandinavia, which resulted from epirogenesis, whereas mountain formation is an orogenesis, which involves both folding and uplift. Darwin was more impressed by uplift than by folds. However, when in Cordillera he saw strata overturned by masses of injected rock, proving successive periods of violence, Darwin took a position, which was closer to the plutonic theories of von Buch and Humboldt than it was to Lyell's uniformitarian views.

  13. [Heinrich von Kleist--crisis and creative overcoming].

    PubMed

    Schlimme, J

    2001-07-01

    Heinrich von Kleist's life was shaken repeatedly by negative life-events, finally he committed suicide in his last life-crisis (1811). His work was mostly understood as descriptions of negative life-events and failed-being. In this article it will be shown that in at least two "crises" Kleist's work can be understood as a creative overcome of those. Kleist shows in his "Essay to Find a Sure Way to Happiness" (1799) his way of solving his "Soldier-Crisis" (1798), a depressive episode. In "The Broken Jug" (1802 - 1805) he shows the implications of a philosophical problem experienced in his "Kant-Crisis" (1801) and offers chances to overcome this particular crisis, which still seems to be an actual problem of ourselves. Though his crises must be understood as depressive episodes, at least the "Kant-Crisis" with its connections to philosophical and artistical matters seems to be more complicated than a simple depressive syndrome. Kleist formulates his basic life-experience, to be repeatedly shaken by "crises" respectively depressive episodes and the necessity to overcome each in a new way of living.

  14. Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.

    PubMed

    Tersteeg, Claudia; Fijnheer, Rob; Pasterkamp, Gerard; de Groot, Philip G; Vanhoorelbeke, Karen; de Maat, Steven; Maas, Coen

    2016-02-01

    Von Willebrand factor (VWF) is one of the most important proteins of the hemostatic system. Its multimeric state is essential for its natural function to guide platelets to sites of injury. ADAMTS13 is the key protease that regulates the multimeric state of VWF. Without ADAMTS13, VWF multimers can grow to pathologically large sizes. This is a risk factor for the life-threatening condition thrombotic thrombocytopenic purpura (TTP). In this condition, VWF-rich thrombi occlude the microvasculature of various tissues. Intriguingly, a complete ADAMTS13 deficiency does not cause continuous TTP, either in patients or genetically targeted mice. Instead, TTP occurs in episodes of disease, separated by extended periods of remission. This indicates that regulating factors beyond ADAMTS13 are likely involved in this pathologic cascade of events. This raises the question of what really happens when ADAMTS13 is (temporarily) unavailable. In this review, we explore the possible role of complementary mechanisms that are capable of modifying the thrombogenic potential of VWF.

  15. Allosteric activation of ADAMTS13 by von Willebrand factor.

    PubMed

    Muia, Joshua; Zhu, Jian; Gupta, Garima; Haberichter, Sandra L; Friedman, Kenneth D; Feys, Hendrik B; Deforche, Louis; Vanhoorelbeke, Karen; Westfield, Lisa A; Roth, Robyn; Tolia, Niraj Harish; Heuser, John E; Sadler, J Evan

    2014-12-30

    The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) within endovascular platelet aggregates, and ADAMTS13 deficiency causes fatal microvascular thrombosis. The proximal metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains of ADAMTS13 recognize a cryptic site in VWF that is exposed by tensile force. Another seven T and two complement C1r/C1s, sea urchin epidermal growth factor, and bone morphogenetic protein (CUB) domains of uncertain function are C-terminal to the MDTCS domains. We find that the distal T8-CUB2 domains markedly inhibit substrate cleavage, and binding of VWF or monoclonal antibodies to distal ADAMTS13 domains relieves this autoinhibition. Small angle X-ray scattering data indicate that distal T-CUB domains interact with proximal MDTCS domains. Thus, ADAMTS13 is regulated by substrate-induced allosteric activation, which may optimize VWF cleavage under fluid shear stress in vivo. Distal domains of other ADAMTS proteases may have similar allosteric properties.

  16. Von Hippel-Lindau disease involving pancreas and biliary system

    PubMed Central

    Zhi, Xu-Ting; Bo, Qi-Yu; Zhao, Feng; Sun, Dong; Li, Tao

    2017-01-01

    Abstract Rationale: Von Hippel-Lindau (VHL) disease is a rare inherited, autosomal-dominant syndrome caused by heterozygous germline mutations in the VHL gene. VHL patients are prone to develop benign and malignant tumors and cysts in multiple organ systems involving kidneys, pancreas and central nervous system (CNS). The varied and complex clinical manifestations and radiological findings of VHL are of interest. Patient concerns: We report a 38-year-old woman with a ten-year history of VHL disease involving both pancreas and biliary system. To the best of our knowledge, direct involvement of the biliary system in VHL disease has never been reported. Diagnoses: The diagnosis was established via computed tomography scan and was confirmed by genetic testing. Interventions: The patient chose to receive conservative treatment and was followed up by magnetic resonance cholangiopancreatography and magnetic resonance imaging examination. Outcomes: Renal angiomas and cysts were found during follow-up and there were no evidence of malignant change of the pancreas and biliary system. Lessons: We described the first case of VHL-associated choledochal cysts and may present new visceral manifestations of VHL disease. Gastroenterologists should be aware of the clinical presentations of this rare disease for early detection of its life-threatening manifestations. PMID:28072736

  17. Principle of reciprocity solves the most important problems in bioimpedance and in general in bioelectromagnetism

    NASA Astrophysics Data System (ADS)

    Malmivuo, Jaakko

    2010-04-01

    Though the principle of reciprocity was invented by Hermann von Helmholtz already over 150 years ago, and though it is a very powerful tool in solving various important problems in bioelectromagnetism, it is not generally used. In impedance tomography the measurement sensitivity distribution has generally been misunderstood. This can be easily demonstrated with the principle of reciprocity. Some other applications of the principle of reciprocity are also discussed.

  18. Multimeric analysis of von Willebrand factor in megakaryocytes.

    PubMed

    Kupinski, J M; Miller, J L

    1985-06-15

    Von Willebrand factor (vWF) is a glycoprotein that appears to play a major role in subserving the adhesion of platelets to subendothelium during hemostasis. Endothelial cells have been shown capable of synthesizing and releasing this large, multimeric glycoprotein that normally circulates in the plasma in association with the factor VIII coagulant molecule. Megakaryocytes, the precursor cells of blood platelets, also appear to possess vWF biosynthetic capacity, since cultured guinea pig megakaryocytes have been shown to produce a polypeptide precipitable by antibody to vWF. We now report a study of the multimeric structure of vWF in the megakaryocyte, as well as a quantitative comparison of megakaryocyte vWF with that of platelets and plasma in the guinea pig. Multimeric analysis on SDS agarose gels employing 125I-emu anti-human vWF revealed striking homology between human and guinea pig vWF. Platelets and megakaryocytes from the same guinea pigs contained vWF of highly comparable multimeric composition. Moreover, megakaryocytes and platelets both contained a subset of very high molecular weight multimers not present in plasma. Quantitation of vWF in megakaryocytes and platelets was achieved with a radioimmunoassay performed on detergent (NP-40) lysates of washed cells. These measurements showed that megakaryocytes and platelets contain 0.079 and 0.069 U of vWF per mg protein, respectively. The results of these studies suggest that megakaryocytes represent the primary, if in fact not sole, source of platelet vWF.

  19. Philipp Frank, Richard von Mises, and the Frank-Mises

    NASA Astrophysics Data System (ADS)

    Siegmund-Schultze, Reinhard

    2007-01-01

    The theoretical physicist Philipp Frank (1884 1966) and the applied mathematician Richard von Mises (1883 1953) both received their university education in Vienna shortly after 1900 and became friends at the latest during the Great War.They were attached to the Vienna Circle of Logical Positivists and wrote an influential two-part work on the differential and integral equations of mechanics and physics, the Frank-Mises, of 1925 and 1927, with its second edition following in 1930 and 1935.This work originated in the lectures that the mathematician Bernhard Riemann (1826 1866) delivered on partial differential equations and their applications to physical questions at the University of Göttingen between 1854 and 1862, which were edited and published posthumously in1869 by the physicist Karl Hattendorff (1834 1882).The immediate precursor of the Frank-Mises, however, was the extensive revision of Hattendorff’s edition of Riemann’s lectures that the mathematician Heinrich Weber (1842 1913) published in two volumes, the Riemann-Weber, of 1900 and 1901, with its second edition following in 1910 and 1912. I trace this historical lineage, explore the nature and contents of the Frank-Mises, and discuss its complementary relationship to the first volume of the text that the mathematicians Richard Courant (1888 1972) and David Hilbert (1862 1943) published on the methods of mathematical physics in 1924, the Courant-Hilbert,which, when it and its second volume of 1937 were translated into English and extensively revised in 1953 and 1961, eclipsed the classic Frank-Mises.

  20. von Willebrand factor storage requires intact prosequence cleavage site.

    PubMed

    Journet, A M; Saffaripour, S; Cramer, E M; Tenza, D; Wagner, D D

    1993-02-01

    Large multimers of the adhesive glycoprotein von Willebrand factor (vWf) are stored in endothelial cells in rod-shaped granules called Weibel-Palade bodies, while small multimers are secreted constitutively. Expression of pro-vWf in other cells with a regulated pathway of secretion, results in formation of vWf-containing storage granules that have a morphology similar to Weibel-Palade bodies. vWf expressed without its prosequence is not stored. To evaluate the importance of prosequence cleavage in vWf storage, the Arg at position -1, known to be necessary for cleavage, was mutated to Gly. Transfection of this cleavage mutant into two cell lines with a regulated pathway of secretion (RIN 5F and AtT-20 cells) led to the formation of large multimers. However, treatment of the cell lysates by the enzyme endoglycosidase H (Endo-H) did not reveal significant amounts of intracellular Endo-H-resistant vWf, which indicates the absence of a pool of stored processed vWf. In addition, no Weibel-Palade body-like structure was detected in these cells by immunofluorescence labeling with anti-vWf antiserum. Electron microscopy and immunocytochemistry of RIN 5F cells expressing the pro-vWf mutant confirmed the absence of Weibel-Palade body-like structures. In addition, anti-vWf-linked gold particles were found in the ER, occasionally in rounded granules and particularly in lysosomal structures which were abundant. We conclude that the formation of large aggregates is not sufficient to induce efficient vWf storage, and that the lack of cleavage of the prosequence may direct the mutant pro-vWf molecule to a degradative pathway. Therefore, the prosequence cleavage is a requirement for vWf storage.

  1. Evaluation of von Willebrand factor in COPD patients*

    PubMed Central

    Bártholo, Thiago Prudente; da Costa, Cláudia Henrique; Rufino, Rogério

    2014-01-01

    OBJECTIVE: To compare the absolute serum von Willebrand factor (vWF) levels and relative serum vWF activity in patients with clinically stable COPD, smokers without airway obstruction, and healthy never-smokers. METHODS: The study included 57 subjects, in three groups: COPD (n = 36); smoker (n = 12); and control (n = 9). During the selection phase, all participants underwent chest X-rays, spirometry, and blood testing. Absolute serum vWF levels and relative serum vWF activity were obtained by turbidimetry and ELISA, respectively. The modified Medical Research Council scale (cut-off score = 2) was used in order to classify COPD patients as symptomatic or mildly symptomatic/asymptomatic. RESULTS: Absolute vWF levels were significantly lower in the control group than in the smoker and COPD groups: 989 ± 436 pg/mL vs. 2,220 ± 746 pg/mL (p < 0.001) and 1,865 ± 592 pg/mL (p < 0.01). Relative serum vWF activity was significantly higher in the COPD group than in the smoker group (136.7 ± 46.0% vs. 92.8 ± 34.0%; p < 0.05), as well as being significantly higher in the symptomatic COPD subgroup than in the mildly symptomatic/asymptomatic COPD subgroup (154 ± 48% vs. 119 ± 8%; p < 0.05). In all three groups, there was a negative correlation between FEV1 (% of predicted) and relative serum vWF activity (r2 = −0.13; p = 0.009). CONCLUSIONS: Our results suggest that increases in vWF levels and activity contribute to the persistence of systemic inflammation, as well as increasing cardiovascular risk, in COPD patients. PMID:25210959

  2. Effect of von Willebrand factor on clot structure and lysis.

    PubMed

    Marchi, Rita; Rojas, Héctor

    2015-07-01

    Von Willebrand Factor (vWF) is constitutively secreted by the endothelium and incorporated in the fibrin clots under slow clotting conditions. The aim of the present work was to study the effect of vWF on clot structure and lysis. Purified fibrinogen was mixed with vWF or Tris-buffered saline and clotted with thrombin - activated factor XIII. Fibrin polymerization was followed by turbidity at 350 nm during 2.5 h. After this time, plasmin was added on the top of the clots, and the optical density (OD) was read until baseline values. vWF effect on network[Combining Acute Accent]s porosity was evaluated by permeation using the same clotting conditions as for fibrin polymerization. Clot structure was visualized and analyzed by laser scanning confocal microscopy (LSCM). The rate of fibrin polymerization was 1.47 mOD/s in the presence of vWF and 0.5 mOD/s when vWF was not added (P < 0.05). The fibrin lysis rate was approximately four times faster when vWF was added to fibrinogen. The fibrin network porosity was (20.4 ± 1.6) × 10 cm with vWF and (8.3 ± 1.2) × 10 cm without external vWF (P < 0.05). The analysis of LSCM images showed that vWF increased fibrin fibers diameter and the networks[Combining Acute Accent] pores size. In conclusion, vWF covalently crosslinked to fibrin modify its structure (increases fibrin diameter and the pores filling space of the meshwork) that accelerates the fibrin lysis rate.

  3. The Man Who Tamed Mexico’s Tiger: General Joaquin Amaro and the Professionalization of Mexico’s Revolutionary Army

    DTIC Science & Technology

    2005-05-01

    Henri Jomini, Karl von Clausewitz, and Helmuth von Moltke. Another staff member, Major Elíseo Martín del Campo , a pilot, held six separate...in 1934 by General Góes Monteiro to President Getúlio Vargas , makes the same point.20 Sounding very much like the “new professionalism” ideology of...known for The Hunchback of Notre Dame and Les Misérables; a magazine collection entitled Némisis by the Colombian-born writer José María Vargas

  4. Uncoordinated expression of fibrinogen compared with thrombospondin and von Willebrand factor in maturing human megakaryocytes.

    PubMed

    Cramer, E M; Debili, N; Martin, J F; Gladwin, A M; Breton-Gorius, J; Harrison, P; Savidge, G F; Vainchenker, W

    1989-04-01

    The localization of three known alpha-granule proteins, thrombospondin (TSP), von Willebrand factor (vWF), and fibrinogen (Fg) has been studied in human megakaryocytes (MK) by immunofluorescence and immunoelectron microscopy. For this study, highly purified populations of MK were prepared from human bone marrow either by counterflow centrifugal elutriation or by cell culture from normal subjects and from two patients with megakaryoblastic leukemia. In normal bone marrow immature MK, TSP, and vWF were observed in the Golgi-associated vesicles and in small immature alpha-granules; in mature MK, they were found in the matrix of the mature large alpha-granules. Surprisingly, Fg was detected neither in the Golgi area, nor in the small precursors of alpha-granules; it was only found in the mature alpha-granules but this labeling was generally weaker than in blood platelets. In order to confirm these differences between the expression of Fg and vWF or TSP additional studies were performed on cultured maturing MK: immunofluorescent and ultrastructural immunogold labeling confirmed that vWF appeared early in the maturation while the same immature MK were negative for Fg. In the late maturation stage, the three proteins were detected in the alpha-granules. In order to know whether Fg was lately synthesized or endocytosed from the outside medium, normal MK were grown in the presence of either normal or afibrinogenemic plasma, and normal serum. Fg was detected only in the alpha-granules of MK grown in normal plasma. Similar results were observed with malignant MK, whose maturation was independent of the culture conditions. In conclusion, this study brings immunocytochemical evidence that vWF and TSP are synthesized by immature MK, whereas Fg appears later in the MK alpha-granules and its expression is dependent of the presence of an exogenous Fg source.

  5. Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology

    PubMed Central

    Smith, Thomas G; Brooks, Jerome T; Balanos, George M; Lappin, Terence R; Layton, D. Mark; Leedham, Dawn L; Liu, Chun; Maxwell, Patrick H; McMullin, Mary F; McNamara, Christopher J; Percy, Melanie J; Pugh, Christopher W; Ratcliffe, Peter J; Talbot, Nick P; Treacy, Marilyn; Robbins, Peter A

    2006-01-01

    Background The von Hippel–Lindau tumour suppressor protein–hypoxia-inducible factor (VHL–HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellular responses to hypoxia, yet insights into its role in systemic human physiology remain limited. Chuvash polycythaemia has recently been defined as a new form of VHL-associated disease, distinct from the classical VHL-associated inherited cancer syndrome, in which germline homozygosity for a hypomorphic VHL allele causes a generalised abnormality in VHL–HIF signalling. Affected individuals thus provide a unique opportunity to explore the integrative physiology of this signalling pathway. This study investigated patients with Chuvash polycythaemia in order to analyse the role of the VHL–HIF pathway in systemic human cardiopulmonary physiology. Methods and Findings Twelve participants, three with Chuvash polycythaemia and nine controls, were studied at baseline and during hypoxia. Participants breathed through a mouthpiece, and pulmonary ventilation was measured while pulmonary vascular tone was assessed echocardiographically. Individuals with Chuvash polycythaemia were found to have striking abnormalities in respiratory and pulmonary vascular regulation. Basal ventilation and pulmonary vascular tone were elevated, and ventilatory, pulmonary vasoconstrictive, and heart rate responses to acute hypoxia were greatly increased. Conclusions The features observed in this small group of patients with Chuvash polycythaemia are highly characteristic of those associated with acclimatisation to the hypoxia of high altitude. More generally, the phenotype associated with Chuvash polycythaemia demonstrates that VHL plays a major role in the underlying calibration and homeostasis of the respiratory and cardiovascular systems, most likely through its central role in the regulation of HIF. PMID:16768548

  6. Ansätze zur Ordnungsreduktion von nichtlinearen Oszillatormodellen zur Anwendung im Schaltungsentwurf

    NASA Astrophysics Data System (ADS)

    Reit, M.; Bremer, J.-K.; Mathis, W.; Stoop, R.

    2010-10-01

    Im Rahmen dieser Arbeit wird ein Konzept zur Ordnungsreduktion von höherdimensionalen nichtlinearen Oszillatormodellen vorgestellt. Hierbei werden zwei wesentliche Ziele verfolgt. Zum einen wird eine höherdimensionale Modellierung der Oszillatorschaltung verwendet. Hierdurch lassen sich die Einflüsse parasitärer Effekte sowie struktureller Erweiterungen auf das dynamische Verhalten des Systems berücksichtigen. Zum anderen wird durch eine anschließende Ordnungsreduktion über die Methode der Zentrumsmannigfaltigkeit eine zweidimensionale Systembeschreibung erzeugt, deren wesentliche Dynamik derjenigen des höherdimensionalen Systems entspricht. Durch diese, in der Ordnung reduzierte, nichtlineare und parameterabhängige Systembeschreibung wird die Anwendbarkeit nichtlinearer Analysemethoden ermöglicht bzw. vereinfacht. Mit der Anwendung der Andronov-Hopf-Bifurkationsanalyse auf das reduzierte System lässt sich eine Stabilitätsuntersuchung durchführen sowie die Amplitude und Frequenz aller Zustandsgrößen approximieren. Das vorgestellte Konzept wird anhand des Beispielsystems eines LC-Tank-VCOs durchgeführt. In this paper, an order reduction technique for higher-dimensional nonlinear oscillator models, based on a center manifold approach, is presented. By modeling the oscillator circuit in the higher-dimensional state space, influences of parasitic elements and of structural extensions of the oscillator architecture on the dynamical system behavior can be examined. Using the proposed order reduction technique, a generalized second order model will be derived, which includes selected design parameters of the higher order model. By using an Andronov-Hopf bifurcation analysis, the reduced system can be studied with respect to stability as well as the amplitude and frequency of the individual state variables. The concept is applied to the design of LC-tank VCOs.

  7. Focal aberrations of large-aperture HOPG von-Hàmos x-ray spectrometers

    NASA Astrophysics Data System (ADS)

    Zastrau, U.; Brown, C. R. D.; Döppner, T.; Glenzer, S. H.; Gregori, G.; Lee, H. J.; Marschner, H.; Toleikis, S.; Wehrhan, O.; Förster, E.

    2012-09-01

    Focal aberrations of large-aperture highly oriented pyrolytic graphite (HOPG) crystals in von-Hàmos geometry are investigated by experimental and computational methods. A mosaic HOPG crystal film of 100 μm thickness diffracts 8 keV x-rays. This thickness is smaller than the absorption depth of the symmetric 004-reflection, which amounts to 257 μm. Cylindrically bent crystals with 110mm radius of curvature and up to 100 mm collection width produce a X-shaped halo around the focus. This feature vanishes when the collection aperture is reduced, but axial spectral profiles show that the resolution is not affected. X-ray topography reveals significant inhomogeneous crystallite domains of 2±1mm diameter along the entire crystal. Rocking curves shift by about ±20arcmin between domains, while their full width at half-maximum varies between 30 and 50 arcmin. These inhomogeneities are not imprinted at the focal spot, since the monochromatically reflecting area of the crystal is large compared to inhomogeneities. Ray-tracing calculations using a Monte-Carlo-based algorithm developed for mosaic crystals reproduce the X-shaped halo in the focal plane, stemming from the mosaic defocussing in the non-dispersive direction in combination with large apertures. The best achievable resolution is found by analyzing a diversity of rocking curve widths, source sizes and crystal thicknesses for 8 keV x-rays to be ΔE/E ~ 10-4. Finally a general analytic expression for the shape of the aberration is derived.

  8. Pattern Formation in Diffusion Flames Embedded in von Karman Swirling Flows

    NASA Technical Reports Server (NTRS)

    Nayagam, Vedha

    2006-01-01

    Pattern formation is observed in nature in many so-called excitable systems that can support wave propagation. It is well-known in the field of combustion that premixed flames can exhibit patterns through differential diffusion mechanism between heat and mass. However, in the case of diffusion flames where fuel and oxidizer are separated initially there have been only a few observations of pattern formation. It is generally perceived that since diffusion flames do not possess an inherent propagation speed they are static and do not form patterns. But in diffusion flames close to their extinction local quenching can occur and produce flame edges which can propagate along stoichiometric surfaces. Recently, we reported experimental observations of rotating spiral flame edges during near-limit combustion of a downward-facing polymethylmethacrylate disk spinning in quiescent air. These spiral flames, though short-lived, exhibited many similarities to patterns commonly found in quiescent excitable media including compound tip meandering motion. Flame disks that grow or shrink with time depending on the rotational speed and in-depth heat loss history of the fuel disk have also been reported. One of the limitations of studying flame patterns with solid fuels is that steady-state conditions cannot be achieved in air at normal atmospheric pressure for experimentally reasonable fuel thickness. As a means to reproduce the flame patterns observed earlier with solid fuels, but under steady-state conditions, we have designed and built a rotating, porous-disk burner through which gaseous fuels can be injected and burned as diffusion flames. The rotating porous disk generates a flow of air toward the disk by a viscous pumping action, generating what is called the von K rm n boundary layer which is of constant thickness over the entire burner disk. In this note we present a map of the various dynamic flame patterns observed during the combustion of methane in air as a function of

  9. A historical perspective: Bernhard von Langenbeck German surgeon (1810-1887).

    PubMed

    Cesmebasi, Alper; Oelhafen, Kim; Shayota, Brian J; Klaassen, Zachary; Tubbs, R Shane; Loukas, Marios

    2014-10-01

    Bernhard von Langenbeck is undeniably one of the world's greatest surgeons and inventors. The influence which he exerted upon the practice of surgery, as apparent by the numerous surgical tools and 21 operations credited to his name, represents the notable contributions of this amazing man. Despite the tools and techniques which bear his name, the establishment of a surgical journal, and his role in co-founding the German Surgical Society, many attest that Bernhard von Langenbeck's greatest contribution to the professional field was the vast knowledge he imparted on his pupils. Commonly credited with training nearly every celebrated surgical operator of his time, von Langenbeck merits posthumous acknowledgement for his vast contributions to the field of medicine and surgery.

  10. P-selectin and von Willebrand factor in bovine mesenteric lymphatics: an immunofluorescent study.

    PubMed

    Di Nucci, A; Marchetti, C; Serafini, S; Piovella, F

    1996-03-01

    P-selectin (PADGEM, GMP-140, CD62) is an integral membrane protein specific to alpha granules of platelets and Weibel-Palade bodies of blood vascular endothelial cells. The presence in lymphatic endothelial cells of numerous Weibel-Palade bodies and their positivity to immunocytochemical reaction for von Willebrand factor have previously been characterized and described. Because von Willebrand factor and P-selectin codistribute in Weibel-Palade bodies of blood vascular endothelial cells we investigated the presence of both P-selectin and von Willebrand factor in lymphatic endothelium. Lymphatic vessels expressed positive reaction to immunocytochemical assay thereby demonstrating the presence of P-selectin in the endothelium. Distribution and intensity of the reaction were similar to those observed in bovine blood vascular endothelium.

  11. An Alternative to Von Glasersfeld's Subjectivism in Science Education: Deweyan Social Constructivism

    NASA Astrophysics Data System (ADS)

    Garrison, Jim

    An influential view of constructivism in science and mathematics educational research and practice is that of Ernst von Glasersfeld. It is a peculiarly subjectivist form of constructivism that should not be attractive to science and mathematics educators concerned with retaining some sort of realism that leaves room for objectivity. The subjectivist constructivism of von Glasersfeld also becomes entangled in untenable mind/body and subject/object dualisms. Finally, these dualisms are unnecessary for social constructivism. I will provide one example of a social constructivist alternative to social constructivism, that of the pragmatic philosopher John Dewey. In presenting Dewey's position I will appeal to Ockham's razor, that is, the admonition not to multiply entities beyond necessity, to shave off the needless mentalistic and psychic entities that lead von Glasersfeld into his subjectivism and dualism.

  12. "'And They Lived Happily Ever After": The Fairy Tale of Radical Constructivism and Von Glasersfeld's Ethical Disengagement

    ERIC Educational Resources Information Center

    d'Agnese, Vasco

    2015-01-01

    Is von Glasersfeld's constructivism actually radical? In this article, I respond to this question by analyzing von Glasersfeld's main works. I argue that the essential theoretical move of radical constructivism--namely the assertion that reality is the construction of a human mind that only responds to the subjective perception of "what…

  13. Die Tabellen von Ulugh Beg. Die Sternkataloge des Ptolemäus, Ulugh Beg und Tycho Brahe im Vergleich

    NASA Astrophysics Data System (ADS)

    Schwan, Heiner

    2002-09-01

    Im 15. Jahrhundert schuf Ulugh Beg, der Herrscher von Samarkand (1394 - 1449), ein wichtiges Tabellenwerk. Das Kernstück dieses Werks (Zij Ulugh Beg, "Tabellen Ulugh Begs") ist ein Katalog mit 1018 Sternen, ihren Helligkeiten und Positionen. In diesem Bericht werden die Zij Ulugh Beg mit den großen Katalogen von Ptolemäus und Tycho Brahe verglichen.

  14. 78 FR 34090 - Lois Von Morganroth; Shiloh Warm Springs Ranch, LLC; Notice of Application for Transfer of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Lois Von Morganroth; Shiloh Warm Springs Ranch, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On April 29, 2013, Lois Von Morganroth (transferor) and Shiloh...

  15. An Integrated Approach to von Willebrand Disease and Surgical Myocardial Revascularization

    PubMed Central

    Jiritano, Federica; Cristodoro, Lucia; Bevacqua, Egidio; Malta, Emanuele; Mastroroberto, Pasquale

    2015-01-01

    Cardiac surgery in patients with preexisting bleeding disorders can be a challenge. Cardiopulmonary bypass can lead to bleeding disorders, above all in patients with coagulopathy. We report the case of a 42-year-old woman, with type I von Willebrand disease, who underwent off-pump coronary artery bypass grafting. Beating heart surgery associated with an adequate replacement of von Willebrand factor and factor VIII levels were chosen to prevent bleeding disorders. Her postoperative course was uneventful and she was discharged home after 5 postoperative days. PMID:26693126

  16. Spontaneous haemothorax associated with von Recklinghausen's disease: review of occurrence in Japan

    PubMed Central

    Miura, H.; Taira, O.; Uchida, O.; Usuda, J.; Hirai, S.; Kato, H.

    1997-01-01

    The case history is presented of a 61 year old man with von Recklinghausen's disease who developed a spontaneous haemothorax. In spite of being asymptomatic for five days after drainage, he died as a result of fatal sudden re-bleeding. The post mortem examination showed dissection and rupture of the left subclavian artery. Microscopically, disarrangement of smooth muscle and decrease of elastic fibre was observed in the ruptured artery. Haemothorax in patients with von Recklinghausen's disease may require thoracotomy, even if the condition of the patient appears to be stable. 


 PMID:9227730

  17. Aufnahme, Analyse und Visualisierung von Bewegungen nativer Herzklappen in-vitro

    NASA Astrophysics Data System (ADS)

    Weiß, Oliver; Friedl, Sven; Kondruweit, Markus; Wittenberg, Thomas

    Die hohe Zahl an Transplantationen von Herzklappen und viele nötige Re-Operationen machen eine detaillierte Analyse der Strömungen und Klappenbewegungen klinisch interessant. Ein neuer Ansatz ist hierbei der Einsatz von Hochgeschwindigkeitskameras um Bewegungsabl äufe der Herzklappen beobachten und auswerten zu können. Die hohen Datenraten erfordern allerdings eine möglichst automatisierte Analyse und möglichst komprimierte Darstellung des Schwingungsverhaltens. In dieser Arbeit wird ein Ansatz vorgestellt, bei dem Bewegungen nativer Herzklappen in-vitro aufgenommen, analysiert und kompakt visualisiert werden.

  18. Gastrointestinal complications of von Recklinghausen's disease: two case reports and a review of the literature.

    PubMed

    Pinsk, I; Dukhno, O; Ovnat, A; Levy, I

    2003-12-01

    There are few reports of the association between neurofibromatosis (von Recklinghausen's disease) and large, solid stromal tumours of the gastrointestinal tract. The prevalence of gastrointestinal involvement in von Recklinghausen's disease has been estimated at 11%-25%. Some associated gastrointestinal stromal tumours present clinically as bowel obstruction, perforation or gastrointestinal bleeding. We recently treated two patients with this condition who presented with gastrointestinal bleeding and were diagnosed with gastrointestinal stromal tumours. We report the unique aspects of these cases and discuss the diagnostic and management problems that are posed by this unusual association.

  19. Species of Typhlophoros von Linstow, 1906 (Nematoda: Ascaridoidea) in Old World crocodilians.

    PubMed

    Sprent, J F

    1999-07-01

    A new species of the genus Typhlophoros von Linstow, 1906, T. spratti, is described from the freshwater crocodile Crocodylus johnstoni and the saltwater crocodile C. porosus in northern Australia. Specimens of the new species could not be compared with the type-species, T. lamellaris, as no preserved specimens of the latter species are known to exist. The new species differs from the descriptions of von Linstow (1906) and Maplestone (1930) in the number of interlabial ridges, the form of the ventriculus and absence of lateral alae. The taxonomic status and affinities of Typhlophoros are discussed.

  20. Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A

    PubMed Central

    Castaman, Giancarlo; Linari, Silvia

    2016-01-01

    Several plasma-derived intermediate and high-purity concentrates containing von Willebrand factor (VWF) and factor VIII (FVIII) are currently available. The main role of these products in the management of the pediatric population is represented by the replacement therapy in patients with severe or intermediate forms of von Willebrand disease, in whom other treatments are ineffective or contraindicated. Another important role of VWF/FVIII concentrates in children may be their use in immune tolerance induction (ITI) protocols. ITI is particularly recommended for hemophilia A children who have developed an inhibitor against FVIII, currently the most serious complication of substitutive treatment in hemophilia. Although recombinant concentrates may represent the preferred option in children with hemophilia A, VWF/FVIII concentrates may offer an advantage in rescuing patients who failed previous ITI. PMID:27445481

  1. Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A.

    PubMed

    Castaman, Giancarlo; Linari, Silvia

    2016-01-01

    Several plasma-derived intermediate and high-purity concentrates containing von Willebrand factor (VWF) and factor VIII (FVIII) are currently available. The main role of these products in the management of the pediatric population is represented by the replacement therapy in patients with severe or intermediate forms of von Willebrand disease, in whom other treatments are ineffective or contraindicated. Another important role of VWF/FVIII concentrates in children may be their use in immune tolerance induction (ITI) protocols. ITI is particularly recommended for hemophilia A children who have developed an inhibitor against FVIII, currently the most serious complication of substitutive treatment in hemophilia. Although recombinant concentrates may represent the preferred option in children with hemophilia A, VWF/FVIII concentrates may offer an advantage in rescuing patients who failed previous ITI.

  2. Experimental Bullard-von Karman dynamo: MHD saturated regimes

    NASA Astrophysics Data System (ADS)

    Miralles, Sophie; Plihon, Nicolas; Pinton, Jean-François

    2014-05-01

    The dynamo instability, converting kinetic energy into magnetic energy, creates the magnetic fields of many astrophysical bodies for which the flows are highly turbulent. Those turbulent fluctuations restricts the range of parameters of numerical and theoretical predictions. As laboratory experiments are closer from natural parameters, this approach is favored in this work. In the past decades, dynamo action has been observed in experiments involving laminar flows [1] or fully turbulent flows [2] in liquid sodium. Nevertheless, the saturation of the velocity field by the Lorentz force due to the dynamo magnetic field is weak in those experiment because the control parameter is always close to the threshold of the instability (which is not the case in astrophysical situations). The details of the mechanism of the back reaction of Lorentz force on the flow are not known. We present here an experimental semi-synthetic dynamo, for which a fluid turbulent induction mechanism ('omega' effect) is associated to an external amplification applying a current into a pair of coils. The flow, called von-Karman, is produced by the counter rotation of two coaxial propellers in a cylindrical tank filled with liquid gallium. The resulting flow is highly turbulent (Re > 10 ^ 5). The amplification, mimicking a turbulent 'alpha' effect, allow to observe the dynamo instability at low magnetic Reynolds number (Rm ~ 2), far below the threshold of natural homogeneous dynamo. This experiment reaches non linear regimes, for which the saturation is a MHD process, at control parameter several times the critical value. The instability grows through an on-off intermittent regime evolving into a full MHD saturated regime for which the Lorentz force is in balance with the inertial one. The power budget is strongly modified by the dynamo magnetic field and we give an insight of the estimated rate of conversion of kinetic energy into magnetic one from experimental data. Very rich regimes such as

  3. Africa’s Oil Coast: How the Region’s Strategic Importance May Cause Operational Challenges for AFRICOM as Currently Constructed

    DTIC Science & Technology

    2014-05-22

    international system. As Carl Dolman states, “strategy is not about the first move, it is a continuous process always presenting other options.”167... Carl Dolman, Presentation to SAMS class 14-01, 20 January 2014. 68 BIBLIOGRAPHY Adegbulu...November 2013). von Clausewitz, Carl . On War, trans. Michael Howard and Peter Paret. Princeton University Press, 1989. Cummings, Thomas G., and

  4. "The captain and canon" C. W. A. von Wahl (1760-1846) (German Title: "Der Hauptmann und Kanonikus" C. W. A. von Wahl (1760-1846) )

    NASA Astrophysics Data System (ADS)

    Brosche, Peter

    Von Wahl was an active member of the group of independent scholars, who were working in the German states within Goethe's time, and who performed astrometric and geodetic observations and calculations. Here we present some cornerstones of his life; longer intervals of it took place in Allstedt south of the Harz and in Halberstadt. Small scientific assets have been preserved at the Universitäts-Sternwarte Bonn. Therein, a lecture on secular variations of the ecliptic is of singular nature.

  5. A Generalization of Generalized Fibonacci and Generalized Pell Numbers

    ERIC Educational Resources Information Center

    Abd-Elhameed, W. M.; Zeyada, N. A.

    2017-01-01

    This paper is concerned with developing a new class of generalized numbers. The main advantage of this class is that it generalizes the two classes of generalized Fibonacci numbers and generalized Pell numbers. Some new identities involving these generalized numbers are obtained. In addition, the two well-known identities of Sury and Marques which…

  6. Citizen in Uniform: Democratic Germany and the Changing Bundeswehr

    DTIC Science & Technology

    2012-03-09

    Bundeswehr. 21 Therefore, General Graf von Baudissin22 advocated that the Bundeswehr be built on the principle of Innere Fuehrung (leadership development...mainly on political education.128 According to Dr. Carl Gleumes, the internal discussion regarding the value of Innere Fuehrung within the Bundeswehr...humanitarian support after a catastrophe.132 This concept began to change with the fall of the Soviet Union and the emergence of a new international

  7. A family of generalized quantum entropies: definition and properties

    NASA Astrophysics Data System (ADS)

    Bosyk, G. M.; Zozor, S.; Holik, F.; Portesi, M.; Lamberti, P. W.

    2016-08-01

    We present a quantum version of the generalized (h,φ )-entropies, introduced by Salicrú et al. for the study of classical probability distributions. We establish their basic properties and show that already known quantum entropies such as von Neumann, and quantum versions of Rényi, Tsallis, and unified entropies, constitute particular classes of the present general quantum Salicrú form. We exhibit that majorization plays a key role in explaining most of their common features. We give a characterization of the quantum (h,φ )-entropies under the action of quantum operations and study their properties for composite systems. We apply these generalized entropies to the problem of detection of quantum entanglement and introduce a discussion on possible generalized conditional entropies as well.

  8. Function of von Willebrand factor after crossed bone marrow transplantation between normal and von Willebrand disease pigs: effect on arterial thrombosis in chimeras.

    PubMed Central

    Nichols, T C; Samama, C M; Bellinger, D A; Roussi, J; Reddick, R L; Bonneau, M; Read, M S; Bailliart, O; Koch, G G; Vaiman, M

    1995-01-01

    von Willebrand factor (vWF) is essential for the induction of occlusive thrombosis in stenosed and injured pig arteries and for normal hemostasis. To separate the relative contribution of plasma and platelet vWF to arterial thrombosis, we produced chimeric normal and von Willebrand disease pigs by crossed bone marrow transplantation; von Willebrand disease (vWD) pigs were engrafted with normal pig bone marrow and normal pigs were engrafted with vWD bone marrow. Thrombosis developed in the chimeric normal pigs that showed normal levels of plasma vWF and an absence of platelet vWF; but no thrombosis occurred in the chimeric vWD pigs that demonstrated normal platelet vWF and an absence of plasma vWF. The ear bleeding times of the chimeric pigs were partially corrected by endogenous plasma vWF but not by platelet vWF. Our animal model demonstrated that vWF in the plasma compartment is essential for the development of arterial thrombosis and that it also contributes to the maintenance of bleeding time and hemostasis. Images Fig. 2 Fig. 3 PMID:7708664

  9. BOOK REVIEW: Meilensteine der Astronomie - Von Aristoteles bis Hawking

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Hamel, J.

    2006-12-01

    A writer, more specific a writer on the history of astronomy, might from time to time look at the collected document folders with all the research material and reprints, and might wonder: has this been all? Especially at a time when recycling is in vogue? And, perhaps with a request or an invitation to submit something, he or she might consider re-using the material before its definitive disposal. Well, such are my feelings when I looked at Jurgen Hamel's new book Milestones of Astronomy - From Aristoteles to Hawking . A slight chance for survival of medium-sized publishers like Kosmos is to offer popular books, and a title must attract potential buyers: Aristoteles means the "old" times, and as concerns the "mad scientist" of modern times, Stephen Hawking has by now dethroned Einstein. In 1998, Hamel had published a Geschichte der Astronomie - Von den Anfangen bis zur Gegenwart (History of astronomy, from the beginnings to the present), which, of course, he could not simply copy. This time, he selected some stones from his research areas - milestones, touchstones, stumbling blocks in the long road of astronomical evolution - and put them between the covers of his new book. So let us look at these (mile)stones . The reader is informed about Aristoteles on 2 pages, but his medieval interpreter Johannes de Sacrobosco gets 8 pages! Copernicus' life and achievements are described on 9 pages, closely followed by his devotee and translator Rothmann with 8 pages; Copernicus' contemporary, Peter Apian, however, gets about 13! Bessel's and Herschel's lifes and works are described on well-deserved 13 and 15 pages, while the achievements of the two Lucasian professors, Isaac Newton and Stephen Hawking, are just outlined in a single paragraph! Thus, importance is sometimes inversely proportional to text length... But let us become serious now. Why should an active historian outline, for the hundreth time, the life of Copernicus, while there are so many interesting, and often

  10. Physik gestern und heute Suprafluidität - Von den Schwierigkeiten einer Messung

    NASA Astrophysics Data System (ADS)

    Sichau, Christian

    2003-03-01

    Der Vater der Tieftemperaturphysik, Heike Kammerlingh Onnes, benötigte zu Beginn des 20. Jahrhunderts für die Verflüssigung von wenigen Litern Heliums noch mehrere Jahre, eine riesige Apparatur und viel Geld. Heute gelingt dies routinemäßig. Die Untersuchung der Materie bei tiefen Temperaturen, insbesondere zur Suprafluidität, bietet viele Überraschungen.

  11. Acquired von Willebrand syndrome in a patient with monoclonal gammopathy of undetermined significance.

    PubMed

    Puronen, Camille E; Josephson, Neil C; Broudy, Virginia C

    2013-06-01

    Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder that typically presents as mucocutaneous bleeding in individuals with no personal or family history of bleeding disorder. Here we present a case in which a patient presented with profound epistaxis and was found to have AVWS in the setting of monoclonal gammopathy of undetermined significance (MGUS).

  12. Definition of the affinity of binding between human von Willebrand factor and coagulation factor VIII.

    PubMed

    Ganz, P R; Atkins, J S; Palmer, D S; Dudani, A K; Hashemi, S; Luison, F

    1991-10-15

    Factor VIII and von Willebrand factor are two plasma proteins essential for effective hemostasis. In vivo, they form a non-covalent complex whose association appears to be metal ion dependent. However, a precise definition of the nature of the molecular forces governing their association remains to be defined, as does their binding affinity. In this paper we have determined the dissociation constant and stoichiometry for Factor VIII binding to immobilized von Willebrand factor. The data demonstrate that these proteins interact saturably and with relatively high affinity. Computer assisted analyses of the Scatchard data favour a two site binding model. The higher affinity site was found to have a Kd of 62 (+/- 13) x 10(-12) M while that of the lower affinity site was 380 (+/- 92) x 10(-12) M. The density of Factor VIII binding sites (Bmax) present on von Willebrand factor was 31 (+/- 3) pM for the high affinity binding site and 46 (+/- 6) pM for the lower site, corresponding to a calculated Factor VIII: von Willebrand factor binding ratio of 1:33 and 1:23, respectively.

  13. Space: The Long-Range Future: An Interview with Jesco von Puttkamer.

    ERIC Educational Resources Information Center

    Lawler, Andrew

    1985-01-01

    Jesco von Puttkamer manages long-range planning in NASA's Office of Space Flight. He believes that space offers the opportunity to ease global tensions, help the developing world, and create a new global culture off the planet. (Author/RM)

  14. Measurement of high-departure aspheres using subaperture stitching with the Variable Optical Null (VON)

    NASA Astrophysics Data System (ADS)

    Kulawiec, Andrew; Murphy, Paul; DeMarco, Michael

    2010-10-01

    Aspheric surfaces are proven to provide significant benefits to a wide variety of optical systems, but the ability to produce high-precision aspheric surfaces has historically been limited by the ability (or lack thereof) to measure them. Traditionally, aspheric measurements have required dedicated null optics, but the cost, lead time, and calibration difficulty of using null optics has made the use of aspheres more challenging and less attractive. In the past three years, QED has developed the Subaperture Stitching Interferometer for Aspheres (SSI-A®) to help address this limitation, providing flexible aspheric measurement capability of up to 200 waves of aspheric departure from best-fit sphere. Some aspheres, however, have thousands of waves of departure. We have recently developed Variable Optical Null (VON) technology that can null much of the aspheric departure in a subaperture. The VON is automatically configurable and is adjusted to nearly null each specific subaperture of an asphere. This ability to nearly null a local subaperture of an asphere provides a significant boost in aspheric measurement capability, enabling aspheres with up to 1000 waves of departure to be measured, without the use of dedicated null optics. We outline the basic principles of subaperture stitching and VON technology, demonstrate the extended capability provided by the VON, and present measurement results from the new Aspheric Stitching Interferometer (ASI®).

  15. A newborn with very rare von Voss-Cherstvoy syndrome: a case report

    PubMed Central

    Sharma, Deepak; Gupta, Basudev; Shastri, Sweta; Sharma, Pradeep

    2016-01-01

    Introduction von Voss-Cherstvoy syndrome is a part of a group of syndromes with radial and hematologic abnormalities, and until now approximately ten cases have been reported in the literature. This syndrome is characterized by a triad of radial ray defects, occipital encephalocele, and urogenital abnormalities. Case presentation We report a neonate from Indian ethnicity who was diagnosed with von Voss-Cherstvoy syndrome. The neonate had radial ray defect, occipital encephalocele, tetralogy of Fallot, and bilateral agenesis of kidney, ureter, and bladder. The neonate was suspected to have von Voss-Cherstvoy syndrome on the basis of clinical features, which was further confirmed by fibroblast analysis showing somatic mosaicism for del(13q). Conclusion von Voss-Cherstvoy syndrome is a very rare syndrome that can be suspected on the basis of typical clinical features and confirmed by fibroblast analysis showing somatic mosaicism for del(13q). This adds a second case of this chromosome anomaly described in this syndrome. PMID:27499650

  16. [Small bowel neurofibromatosis in Von Recklinghausen's disease. A rare cause of emergency surgery].

    PubMed

    Ben Achour, Jamel; Hani, Mohamed Aziz; Bouasker, Ibtissem; Guesmi, Fethi; Zoghlami, Ayoub; Najah, Nabil

    2003-11-01

    Two cases of small bowel neurofibromatosis in patients with Von Recklinghausen's disease are reported. Diagnosis of small bowel neurofibromatosis was made on the occasion of a complication for the two cases. We insist on the difficulty of diagnosis as well as in presence or not of complications. Treatment of these most often benign tumours remains surgical based on a segmental small bowel resection.

  17. Plexiform neurofibroma of the submandibular gland in patient with von Recklinghausen's disease

    PubMed Central

    Bisher, Hassan Al; Kant, Ravi; Aldamati, Ahmed; Badar, Aysha Ahmed

    2011-01-01

    Plexiform neurofibroma of the submandibular gland is an extremely rare tumor. Herein, we report a case of plexiform neurofibroma in a patient with a von Recklinghausen's disease (NF-1) who presented with a submandibular mass mimicking a submandibular gland tumor. Complete surgical excision provides the best treatment and final diagnosis. A neurofibroma should be considered in the differential diagnosis for submandibular mass. PMID:21464877

  18. Spontaneous haemothorax: a cause of sudden death in von Recklinghausen's disease.

    PubMed Central

    Griffiths, A. P.; White, J.; Dawson, A.

    1998-01-01

    Vasculopathy is a relatively frequent but poorly recognised manifestation of von Recklinghausen's neurofibromatosis. One of its more dramatic presentations is as spontaneous haemothorax. Clinicians and pathologists should be aware of this syndrome as a cause of sudden death in patients with neurofibromatosis. Images Figure 1 Figure 2 PMID:10197217

  19. Beyond victimhood. The struggle of Munich anatomist Titus von Lanz during National Socialism.

    PubMed

    Schütz, Mathias; Waschke, Jens; Marckmann, Georg; Steger, Florian

    2015-09-01

    The article analyzes the life and career of the anatomist Titus von Lanz (1897-1967) of Munich focusing on the period of National Socialism (NS). Von Lanz lost his position as an associate professor at the Anatomical Institute of Munich University because of his marriage to a "half-Jewish" woman in 1938. In contrast to most of his colleagues affected by National Socialist measures, von Lanz had opportunities to save his career and made extensive use of them. His story is that of a complicated struggle for the continuation of his work, involving a wide range of supporters from prestigious physicians to high-ranking National Socialist officials as well as the alienation of his colleagues at the Munich department of anatomy. The article tries to clarify these developments through the presentation of his social background, his supporters, his enemies, the research he conducted during NS and von Lanz' own remembrance of these developments from the post-war period. It aims at laying out a critical appreciation of his motives and actions, thereby contributing to the understanding of individual behavior of anatomists under NS.

  20. Dr. Wernher Von Braun on Tour With U.S. congressman Armistead Seldon

    NASA Technical Reports Server (NTRS)

    1999-01-01

    U.S. representative Armistead Seldon (D.-Al) tries on an astronaut maneuvering unit mockup during a tour of the Saturn I workshop at the Marshall Space Flight center. Explaining the unit and the workshop to Representative Seldon is Dr. Wernher Von Braun, director of the Marshall Center.