Computer programming for generating visual stimuli.

PubMed

Bukhari, Farhan; Kurylo, Daniel D

2008-02-01

Critical to vision research is the generation of visual displays with precise control over stimulus metrics. Generating stimuli often requires adapting commercial software or developing specialized software for specific research applications. In order to facilitate this process, we give here an overview that allows nonexpert users to generate and customize stimuli for vision research. We first give a review of relevant hardware and software considerations, to allow the selection of display hardware, operating system, programming language, and graphics packages most appropriate for specific research applications. We then describe the framework of a generic computer program that can be adapted for use with a broad range of experimental applications. Stimuli are generated in the context of trial events, allowing the display of text messages, the monitoring of subject responses and reaction times, and the inclusion of contingency algorithms. This approach allows direct control and management of computer-generated visual stimuli while utilizing the full capabilities of modern hardware and software systems. The flowchart and source code for the stimulus-generating program may be downloaded from www.psychonomic.org/archive.

Research, Design, and Implementation of an Internship Course in Dance: Turning Student Knowledge into Professional Know-How

ERIC Educational Resources Information Center

Risner, Doug

2015-01-01

A successful internship experience can provide invaluable learning experiences connecting students' classroom knowledge to professional "know-how" in the field. Over the past three decades, post-secondary internship programs have flourished, generating considerable research literature from a variety of disciplinary perspectives; however,…

Earth integrated design: office dormitory facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shapira, H. B.; Barnes, P. R.

1980-01-01

The generation process of the design of the Joint Institute for Heavy Ion Research is described. Architectural and energy considerations are discussed. The facility will contain living quarters for guest scientists who come to Oak Ridge to conduct short experiments and sleeping alcoves for local researchers on long experimental shifts as well as office space. (MHR)

Navigating Pre-, In-, and Post-Fieldwork: Elements for Consideration

ERIC Educational Resources Information Center

Lamoureux, Sylvie A.

2011-01-01

In this article, the author reflects on the transitions she has navigated since 2005 and offers insight into elements of research relationships. As she guides and accompanies a new generation of qualitative researchers planning and experiencing their fieldwork, the need for writing that addresses the complexities of "the intersubjectivity of the…

Performance Rating Accuracy Improvement through Changes in Individual and System Characteristics.

ERIC Educational Resources Information Center

Kavanagh, Michael J.

Although the quest for better measurement of individual job performance has generated considerable empirical research in industrial and organizational psychology, the feeling persists that a good job is not really being done in measuring job performance. This research project investigated the effects of differences in both individual and systems…

Community-level climate change vulnerability research: trends, progress, and future directions

NASA Astrophysics Data System (ADS)

McDowell, Graham; Ford, James; Jones, Julie

2016-03-01

This study systematically identifies, characterizes, and critically evaluates community-level climate change vulnerability assessments published over the last 25 years (n = 274). We find that while the field has advanced considerably in terms of conceptual framing and methodological approaches, key shortcomings remain in how vulnerability is being studied at the community-level. We argue that vulnerability research needs to more critically engage with the following: methods for evaluating future vulnerability, the relevance of vulnerability research for decision-making, interdependencies between social and ecological systems, attention to researcher / subject power dynamics, critical interpretation of key terms, and consideration of the potentially positive opportunities presented by a changing climate. Addressing these research needs is necessary for generating knowledge that supports climate-affected communities in navigating the challenges and opportunities ahead.

Qualitative Research for Patient Safety Using ICTs: Methodological Considerations in the Technological Age.

PubMed

Yee, Kwang Chien; Wong, Ming Chao; Turner, Paul

2017-01-01

Considerable effort and resources have been dedicated to improving the quality and safety of patient care through health information systems, but there is still significant scope for improvement. One contributing factor to the lack of progress in patient safety improvement especially where technology has been deployed relates to an over-reliance on purely objective, quantitative, positivist research paradigms as the basis for generating and validating evidence of improvement. This paper argues the need for greater recognition and accommodation of evidence of improvement generated through more subjective, qualitative and pragmatic research paradigms to aid patient safety especially where technology is deployed. This paper discusses how acknowledging the role and value of more subjective ontologies and pragmatist epistemologies can support improvement science research. This paper illustrates some challenges and benefits from adopting qualitative research methods in patient safety improvement projects, particularly focusing challenges in the technological era. While adopting methods that can more readily capture, analyse and interpret direct user experiences, attitudes, insights and behaviours in their contextual settings, patient safety can be enhanced 'on the ground' and errors reduced and/or mitigated, challenges of using these methods with the younger "technologically-centred" healthcare professionals and patients needs to recognised.

A Consideration of the Case for Using Life Story Interviews in the Evaluation of Widening Access Interventions

ERIC Educational Resources Information Center

Raven, Neil

2016-01-01

Whilst published data sources exist for evaluating interventions aimed at widening higher education access, there is value for practitioners in conducting their own research. However, recognition of the contribution afforded by generating new data raises questions over which research methods to utilise. One method relatively new to widening…

Investigating the "g"-Saturation of Various Stratum-Two Factors Using Automatic Item Generation

ERIC Educational Resources Information Center

Arendasy, Martin E.; Hergovich, Andreas; Sommer, Markus

2008-01-01

Even though researchers agree on the hierarchical structure of intelligence there is considerable disagreement on the g-saturation of the lower stratum-two factors. In this article it is argued that the mixed evidence in the research literature can be at least partially attributed to the construct representation of the individual tests used to…

Variations in Scientific Data Production: What Can We Learn from #Overlyhonestmethods?

PubMed

Bezuidenhout, Louise

2015-12-01

In recent months months the hashtag #overlyhonestmethods has steadily been gaining popularity. Posts under this hashtag--presumably by scientists--detail aspects of daily scientific research that differ considerably from the idealized interpretation of scientific experimentation as standardized, objective and reproducible. Over and above its entertainment value, the popularity of this hashtag raises two important points for those who study both science and scientists. Firstly, the posts highlight that the generation of data through experimentation is often far less standardized than is commonly assumed. Secondly, the popularity of the hashtag together with its relatively blasé reception by the scientific community reveal that the actions reported in the tweets are far from shocking and indeed may be considered just "part of scientific research". Such observations give considerable pause for thought, and suggest that current conceptions of data might be limited by failing to recognize this "inherent variability" within the actions of generation--and thus within data themselves. Is it possible, we must ask, that epistemic virtues such as standardization, consistency, reportability and reproducibility need to be reevaluated? Such considerations are, of course, of particular importance to data sharing discussions and the Open Data movement. This paper suggests that the notion of a "moral professionalism" for data generation and sharing needs to be considered in more detail if the inherent variability of data are to be addressed in any meaningful manner.

Design factors and considerations for a time-based flight management system

NASA Technical Reports Server (NTRS)

Vicroy, D. D.; Williams, D. H.; Sorensen, J. A.

1986-01-01

Recent NASA Langley Research Center research to develop a technology data base from which an advanced Flight Management System (FMS) design might evolve is reviewed. In particular, the generation of fixed range cruise/descent reference trajectories which meet predefined end conditions of altitude, speed, and time is addressed. Results on the design and theoretical basis of the trajectory generation algorithm are presented, followed by a brief discussion of a series of studies that are being conducted to determine the accuracy requirements of the aircraft and weather models resident in the trajectory generation algorithm. Finally, studies to investigate the interface requirements between the pilot and an advanced FMS are considered.

The Role of Schools in Bridging Within-School Achievement Gaps Based on Socioeconomic Status: A Cross-National Comparative Study

ERIC Educational Resources Information Center

Huang, Haigen; Sebastian, James

2015-01-01

Since the publication of the Coleman report in 1966, research on the role of schools in influencing student achievement relative to the role of family background has generated considerable interest and controversy. A large volume of international and comparative research has also been devoted to studying school effects on student achievement.…

Creating a Next-Generation System of K-12 English Learner Language Proficiency Assessments. Research Report. ETS RR-16-06

ERIC Educational Resources Information Center

Hauck, Maurice Cogan; Wolf, Mikyung Kim; Mislevy, Robert

2016-01-01

This paper is the first in a series from Educational Testing Service (ETS) concerning English language proficiency (ELP) assessments for K-12 English learners (ELs). The goal of this paper, and the series, is to present research-based ideas, principles, and recommendations for consideration by those who are conceptualizing, developing, and…

DNA Immunization

PubMed Central

Wang, Shixia; Lu, Shan

2013-01-01

DNA immunization was discovered in early 1990s and its use has been expanded from vaccine studies to a broader range of biomedical research, such as the generation of high quality polyclonal and monoclonal antibodies as research reagents. In this unit, three common DNA immunization methods are described: needle injection, electroporation and gene gun. In addition, several common considerations related to DNA immunization are discussed. PMID:24510291

[The transgenerational transmission of traumatic experiences of the Second World War over three generations--a psychoanalytical perspective].

PubMed

Silke, Wiegand-Grefe; Möller, Birgit

2012-01-01

The paper presents some reflections on the transgenerational transmission of traumatic experiences of war and in particular bombing during Second World War. These theoretical considerations are based on a case study (family interview) deriving from the research project "Kriegskindheit im Hamburger Feuersturm" additionally illustrated and complemented with impressions based on interviews with three generations in context of the project.

Simplified Novel Application (SNApp) framework: a guide to developing and implementing second-generation mobile applications for behavioral health research.

PubMed

Fillo, Jennifer; Staplefoote-Boynton, B Lynette; Martinez, Angel; Sontag-Padilla, Lisa; Shadel, William G; Martino, Steven C; Setodji, Claude M; Meeker, Daniella; Scharf, Deborah

2016-12-01

Advances in mobile technology and mobile applications (apps) have opened up an exciting new frontier for behavioral health researchers, with a "second generation" of apps allowing for the simultaneous collection of multiple streams of data in real time. With this comes a host of technical decisions and ethical considerations unique to this evolving approach to research. Drawing on our experience developing a second-generation app for the simultaneous collection of text message, voice, and self-report data, we provide a framework for researchers interested in developing and using second-generation mobile apps to study health behaviors. Our Simplified Novel Application (SNApp) framework breaks the app development process into four phases: (1) information and resource gathering, (2) software and hardware decisions, (3) software development and testing, and (4) study start-up and implementation. At each phase, we address common challenges and ethical issues and make suggestions for effective and efficient app development. Our goal is to help researchers effectively balance priorities related to the function of the app with the realities of app development, human subjects issues, and project resource constraints.

Promise and Peril: Dissemination of Findings from Studies of Drugs Used in Pregnancy and Their Association with Birth Defects

PubMed Central

Patrick, Stephen W.; Cooper, William O.

2015-01-01

When and how to publish birth defects research can be complex, especially in the context of drugs used in pregnancy. Such research frequently involves multiple stakeholders, including regulatory agencies. Researchers must balance the potential peril of an unnecessarily panicked populace versus the benefit of protecting the public's health. We use a case presentation and contemporary literature to highlight the potential tradeoffs that researchers must consider. We highlight important considerations including the public health impact, examining the likelihood of causality, understanding common considerations when using large data sources, the role of peer review and working in partnership with regulatory agencies. We suggest that plans for analyses, dissemination and risk communication are done best a priori and not post hoc. Rigorous research evaluating the impact of drugs used in pregnancy, coupled with effective dissemination strategies, has the potential improve outcomes for mothers and their infants for generations. PMID:26153150

NITROUS OXIDE BEHAVIOR IN THE ATMOSPHERE, AND IN COMBUSTION AND INDUSTRIAL SYSTEMS

EPA Science Inventory

Tropospheric measurements show that nitrous oxide (N2O) concentrations are increasing over time. This demonstrates the existence of one or more significant anthropogenic sources, a fact that has generated considerable research interest over the last several years. The debate has ...

Editorial. Recent advances and new challenges of occupational and environmental health of nanotechnology

NASA Astrophysics Data System (ADS)

Tsai, Chuen-Jinn; Pui, David Y. H.

2009-01-01

An overview of the special issue of the Journal of Nanoparticle Research on Occupational and Environmental Health of nanotechnology is presented. Papers published in this special issue show considerable progress in understanding nanoparticle toxicity, monitoring, generation, dustiness, filtration, and applications of nanoparticles. More research is needed to ensure safe handling of nanomaterials as nanotechnology continues to develop at an incredible pace.

Marketing and commercialization of computational research services.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toevs, J. W.

Physical and computational scientists and mathematicians in Russia's nuclear cities are turning their work toward generating profits from Western markets. Successful ventures require an understanding of the marketing of contract research as well as Western expectations regarding contract execution, quality, and performance. This paper will address fundamentals in business structure, marketing, and contract performance for organizations engaging in the marketing and commercialization of research services. Considerable emphasis will be placed on developing adequate communication within the organization.

Considerations for Infectious Disease Research Studies Using Animals

PubMed Central

Colby, Lesley A; Quenee, Lauriane E; Zitzow, Lois A

2017-01-01

Animal models are vital in understanding the transmission and pathogenesis of infectious organisms and the host immune response to infection. In addition, animal models are essential in vaccine and therapeutic drug development and testing. Prior to selecting an animal model to use when studying an infectious agent, the scientific team must determine that sufficient in vitro and ex vivo data are available to justify performing research in an animal model, that ethical considerations are addressed, and that the data generated from animal work will add useful information to the body of scientific knowledge. Once it is established that an animal should be used, the questions become ‘Which animal model is most suitable?’ and ‘Which experimental design issues should be considered?’ The answers to these questions take into account numerous factors, including scientific, practical, welfare, and regulatory considerations, which are the focus of this article. PMID:28662751

Ethical and Clinical Considerations at the Intersection of Functional Neuroimaging and Disorders of Consciousness.

PubMed

Byram, Adrian C; Lee, Grace; Owen, Adrian M; Ribary, Urs; Stoessl, A Jon; Townson, Andrea; Illes, Judy

2016-10-01

Recent neuroimaging research on disorders of consciousness provides direct evidence of covert consciousness otherwise not detected clinically in a subset of severely brain-injured patients. These findings have motivated strategic development of binary communication paradigms, from which researchers interpret voluntary modulations in brain activity to glean information about patients' residual cognitive functions and emotions. The discovery of such responsiveness raises ethical and legal issues concerning the exercise of autonomy and capacity for decisionmaking on matters such as healthcare, involvement in research, and end of life. These advances have generated demands for access to the technology against a complex background of continued scientific advancement, questions about just allocation of healthcare resources, and unresolved legal issues. Interviews with professionals whose work is relevant to patients with disorders of consciousness reveal priorities concerning further basic research, legal and policy issues, and clinical considerations.

Security Approaches in Using Tablet Computers for Primary Data Collection in Clinical Research

PubMed Central

Wilcox, Adam B.; Gallagher, Kathleen; Bakken, Suzanne

2013-01-01

Next-generation tablets (iPads and Android tablets) may potentially improve the collection and management of clinical research data. The widespread adoption of tablets, coupled with decreased software and hardware costs, has led to increased consideration of tablets for primary research data collection. When using tablets for the Washington Heights/Inwood Infrastructure for Comparative Effectiveness Research (WICER) project, we found that the devices give rise to inherent security issues associated with the potential use of cloud-based data storage approaches. This paper identifies and describes major security considerations for primary data collection with tablets; proposes a set of architectural strategies for implementing data collection forms with tablet computers; and discusses the security, cost, and workflow of each strategy. The paper briefly reviews the strategies with respect to their implementation for three primary data collection activities for the WICER project. PMID:25848559

Security approaches in using tablet computers for primary data collection in clinical research.

PubMed

Wilcox, Adam B; Gallagher, Kathleen; Bakken, Suzanne

2013-01-01

Next-generation tablets (iPads and Android tablets) may potentially improve the collection and management of clinical research data. The widespread adoption of tablets, coupled with decreased software and hardware costs, has led to increased consideration of tablets for primary research data collection. When using tablets for the Washington Heights/Inwood Infrastructure for Comparative Effectiveness Research (WICER) project, we found that the devices give rise to inherent security issues associated with the potential use of cloud-based data storage approaches. This paper identifies and describes major security considerations for primary data collection with tablets; proposes a set of architectural strategies for implementing data collection forms with tablet computers; and discusses the security, cost, and workflow of each strategy. The paper briefly reviews the strategies with respect to their implementation for three primary data collection activities for the WICER project.

Review of physical activity measurement using accelerometers in older adults: considerations for research design and conduct.

PubMed

Murphy, Susan L

2009-02-01

Accelerometers are being increasingly used in studies of physical activity (PA) among older adults, however the use of these monitors requires some specialized knowledge and up-to-date information on technological innovations. The purpose of this review article is to provide researchers with a guide to some commonly-used accelerometers in order to better design and conduct PA research with older adults. A literature search was conducted to obtain all available literature on commonly-used accelerometers in older adult samples with specific attention to articles discussing research design. The use of accelerometers in older adults requires a basic understanding of the type being used, rationale for their placement, and attention to calibration when needed. The updated technology in some monitors should make study conduct less difficult, however comparison studies of the newer versus the older generation models will be needed. Careful considerations for design and conduct of accelerometer research as outlined in this review should help to enhance the quality and comparability of future research studies.

Preparing the New Generation of CALL Researchers and Practitioners: What Nine Months in an MA Program Can (or Cannot) Do

ERIC Educational Resources Information Center

Hegelheimer, Volker; Reppert, Ketty; Broberg, Megan; Daisy, Brenda; Grgurovic, Maja; Middlebrooks, Katy; Liu, Sammi

2004-01-01

As more and more teacher preparation programs realize the need to include courses that deal with computer-assisted language learning, a crucial decision as to what is taught needs to be made, taking into consideration the various post-graduation goals ranging from teacher or teacher-trainer to researcher. Thus, the question of whether to go beyond…

Electric Power Generation Systems for Use in Space

DTIC Science & Technology

1960-07-20

source of power . It is available from two sources, namely, nuclear fission and radioisotope decay. In both cases, the energy is available in...limitations on inventory size as well as spe- cific weight considerations will restrict radioisotope systems to power levels below about 1 kilowatt. It is... POWER GENERATION SYSTEMS FOR USE IN SPA TIC By Henry 0. Slone and Seymour Lieblein -y 6, "IN 13 pLewis Research Center G 0 3 1994 Nation Aeronautics

Crop residue considerations for sustainable biomass feedstock supplies

USDA-ARS?s Scientific Manuscript database

Corn (Zea mays, L.) stover was identified as an important feedstock for second generation biofuel production in the U.S. because of the extensive area upon which the crop is grown. This presentation will summarize 239 site-years of field research examining effects of zero, moderate, and high stover ...

Promise and peril: Dissemination of findings from studies of drugs used in pregnancy and their association with birth defects.

PubMed

Patrick, Stephen W; Cooper, William O

2015-08-01

When and how to publish birth defects research can be complex, especially in the context of drugs used in pregnancy. Such research frequently involves multiple stakeholders, including regulatory agencies. Researchers must balance the potential peril of an unnecessarily panicked populace versus the benefit of protecting the public's health. We use a case presentation and contemporary literature to highlight the potential tradeoffs that researchers must consider. We highlight important considerations including the public health impact, examining the likelihood of causality, understanding common considerations when using large data sources, the role of peer review and working in partnership with regulatory agencies. We suggest that plans for analyses, dissemination and risk communication are done best a priori and not post hoc. Rigorous research evaluating the impact of drugs used in pregnancy, coupled with effective dissemination strategies, has the potential improve outcomes for mothers and their infants for generations. © 2015 Wiley Periodicals, Inc.

Developmental Programming: State-of-the-Science and Future Directions

PubMed Central

Sutton, Elizabeth F.; Gilmore, L. Anne; Dunger, David B.; Heijmans, Bas T.; Hivert, Marie-France; Ling, Charlotte; Martinez, J. Alfredo; Ozanne, Susan E.; Simmons, Rebecca A.; Szyf, Moshe; Waterland, Robert A.; Redman, Leanne M.; Ravussin, Eric

2016-01-01

Objective On December 8–9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies and human clinical trials, (ii) the state-of-the-science of epigenetic-based research, and (iii) considerations for future studies. Results The overarching goal was to provide a comprehensive assessment of the state of the scientific field, to identify research gaps and opportunities for future research in order to identify and understand the mechanisms contributing to the developmental programming of health and disease. Conclusions Identifying the mechanisms which cause or contribute to developmental programming of future generations will be invaluable to the scientific and medical community. The ability to intervene during critical periods of prenatal and early postnatal life to promote lifelong health is the ultimate goal. Considerations for future research including the use of animal models, the study design in human cohorts with considerations about the timing of the intrauterine exposure and the resulting tissue specific epigenetic signature were extensively discussed and are presented in this meeting summary. PMID:27037645

Revealing the Interactional Features of Learning and Teaching Moments in Outdoor Activity

ERIC Educational Resources Information Center

Waters, Jane; Bateman, Amanda

2015-01-01

The data considered in this article was generated as part of a doctoral research study entitled: "A sociocultural consideration of child-initiated interaction with teachers in indoor and outdoor spaces" (Waters 2011) where child-initiated, teacher-child interaction in indoor and outdoor spaces were investigated. The purpose of the…

Foucault's Toolbox: Critical Insights for Education and Technology Researchers

ERIC Educational Resources Information Center

Hope, Andrew

2015-01-01

Despite having been a prolific academic, whose work exerts considerable cross-discipline influence, the ideas of Foucault are largely neglected in educational technology scholarship. Having provided an initial brief overview of the sparse use of Foucault's work in this sub-field, this paper then seeks to generate new understandings, arguing that…

Positive Illusions of Preference Consistency: When Remaining Eluded by One's Preferences Yields Greater Subjective Well-Being and Decision Outcomes

ERIC Educational Resources Information Center

Wells, Rachael E.; Iyengar, Sheena S.

2005-01-01

Psychological research has repeatedly demonstrated two seemingly irreconcilable human tendencies. People are motivated towards internal consistency, or acting in accordance with stable, self-generated preferences. Simultaneously though, people demonstrate considerable variation in the content of their preferences, often induced by subtle external…

Textbook Citations as a Measure of Journal Influence on International Business Education

ERIC Educational Resources Information Center

Urbancic, Frank R.

2006-01-01

Previously published rankings of journals in relation to international business research are based on a survey method or a journal-based citation method wherein functional discipline journals are excluded from consideration. The narrow focus of these studies has generated criticism for perpetuating an international business silo perspective. In…

Solar Energy Evolution and Diffusion Studies: 2014-2016 | Solar Research |

Science.gov Websites

motivations for adoption A non-adopter considerer survey that targeted lost leads by installers to identify two experimental market pilots to test methods to increase lead generation and conversion using concerned individuals may need to emphasize non-environmental benefits. The results also support leveraging

Schools as Organizations: Examining School Climate, Teacher Turnover, and Student Achievement in NYC. Brief

ERIC Educational Resources Information Center

Kraft, Matthew A.; Marinell, William H.; Yee, Darrick

2016-01-01

During the last decade, education research and policy have generated considerable momentum behind efforts to remake teacher evaluation systems and place an effective teacher in every classroom. But schools are not simply collections of individual teachers; they are also organizations, with structures, practices, and norms that may impede or…

Students with Disabilities at Degree-Granting Postsecondary Institutions. First Look. NCES 2011-018

ERIC Educational Resources Information Center

Raue, Kimberley; Lewis, Laurie

2011-01-01

Growing enrollments of students with disabilities in postsecondary education along with recent key legislation such as the Americans with Disabilities Act Amendments Act of 2008 and the 2008 Higher Education Opportunity Act, have generated considerable interest in research on accessibility of higher education for students with disabilities. This…

Using E-Maps to Organize and Navigate Online Content

ERIC Educational Resources Information Center

Ruffini, Michael F.

2008-01-01

Computer-generated mind maps, or e-maps, provide an outstanding e-learning tool for organizing and navigating web-based content and files. Considerable research indicates the effectiveness of using graphic organizers such as mind maps to facilitate meaningful learning. Tony Buzan and Barry Buzan argue that mind maps better harness the way the…

Aerobiology: Experimental Considerations, Observations, and Future Tools

PubMed Central

Haddrell, Allen E.

2017-01-01

ABSTRACT Understanding airborne survival and decay of microorganisms is important for a range of public health and biodefense applications, including epidemiological and risk analysis modeling. Techniques for experimental aerosol generation, retention in the aerosol phase, and sampling require careful consideration and understanding so that they are representative of the conditions the bioaerosol would experience in the environment. This review explores the current understanding of atmospheric transport in relation to advances and limitations of aerosol generation, maintenance in the aerosol phase, and sampling techniques. Potential tools for the future are examined at the interface between atmospheric chemistry, aerosol physics, and molecular microbiology where the heterogeneity and variability of aerosols can be explored at the single-droplet and single-microorganism levels within a bioaerosol. The review highlights the importance of method comparison and validation in bioaerosol research and the benefits that the application of novel techniques could bring to increasing the understanding of aerobiological phenomena in diverse research fields, particularly during the progression of atmospheric transport, where complex interdependent physicochemical and biological processes occur within bioaerosol particles. PMID:28667111

Language barriers and qualitative nursing research: methodological considerations.

PubMed

Squires, A

2008-09-01

This review of the literature synthesizes methodological recommendations for the use of translators and interpreters in cross-language qualitative research. Cross-language qualitative research involves the use of interpreters and translators to mediate a language barrier between researchers and participants. Qualitative nurse researchers successfully address language barriers between themselves and their participants when they systematically plan for how they will use interpreters and translators throughout the research process. Experienced qualitative researchers recognize that translators can generate qualitative data through translation processes and by participating in data analysis. Failure to address language barriers and the methodological challenges they present threatens the credibility, transferability, dependability and confirmability of cross-language qualitative nursing research. Through a synthesis of the cross-language qualitative methods literature, this article reviews the basics of language competence, translator and interpreter qualifications, and roles for each kind of qualitative research approach. Methodological and ethical considerations are also provided. By systematically addressing the methodological challenges cross-language research presents, nurse researchers can produce better evidence for nursing practice and policy making when working across different language groups. Findings from qualitative studies will also accurately represent the experiences of the participants without concern that the meaning was lost in translation.

Language barriers and qualitative nursing research: methodological considerations

PubMed Central

Squires, A.

2009-01-01

Aim This review of the literature synthesizes methodological recommendations for the use of translators and interpreters in cross-language qualitative research. Background Cross-language qualitative research involves the use of interpreters and translators to mediate a language barrier between researchers and participants. Qualitative nurse researchers successfully address language barriers between themselves and their participants when they systematically plan for how they will use interpreters and translators throughout the research process. Experienced qualitative researchers recognize that translators can generate qualitative data through translation processes and by participating in data analysis. Failure to address language barriers and the methodological challenges they present threatens the credibility, transferability, dependability and confirmability of cross-language qualitative nursing research. Through a synthesis of the cross-language qualitative methods literature, this article reviews the basics of language competence, translator and interpreter qualifications, and roles for each kind of qualitative research approach. Methodological and ethical considerations are also provided. Conclusion By systematically addressing the methodological challenges cross-language research presents, nurse researchers can produce better evidence for nursing practice and policy making when working across different language groups. Findings from qualitative studies will also accurately represent the experiences of the participants without concern that the meaning was lost in translation. PMID:19522941

System description and analysis. Part 1: Feasibility study for helicopter/VTOL wide-angle simulation image generation display system

NASA Technical Reports Server (NTRS)

1977-01-01

A preliminary design for a helicopter/VSTOL wide angle simulator image generation display system is studied. The visual system is to become part of a simulator capability to support Army aviation systems research and development within the near term. As required for the Army to simulate a wide range of aircraft characteristics, versatility and ease of changing cockpit configurations were primary considerations of the study. Due to the Army's interest in low altitude flight and descents into and landing in constrained areas, particular emphasis is given to wide field of view, resolution, brightness, contrast, and color. The visual display study includes a preliminary design, demonstrated feasibility of advanced concepts, and a plan for subsequent detail design and development. Analysis and tradeoff considerations for various visual system elements are outlined and discussed.

The dream in contemporary psychiatry.

PubMed

Reiser, M F

2001-03-01

This article offers selective reviews of cogent sectors of research regarding the dream in contemporary psychiatry. First, the author discusses relatively recent research (1953-1999) on the neurobiology and clinical psychophysiology of dreaming sleep; second, he reviews experimental cognitive neuroscientific studies of perception, emotion, and memory and the putative interrelationships among them in generating dream imagery; and third, he interprets psychoanalytic studies (1900-1999) on related aspects of dreams and the dream process. Exploration for interrelationships among information from these three areas entails discussion of the mind/brain problem. These considerations illuminate some of the logical and interpretive dilemmas that enter into debates about Freud's theory of the dream. The author proposes a preliminary psychobiologic concept of the dream process and discusses, in light of the foregoing considerations, the importance of collaborative research for developing a realistic perspective concerning the proper place of the dream in contemporary psychiatry.

Development of Structural Health Management Technology for Aerospace Vehicles

NASA Technical Reports Server (NTRS)

Prosser, W. H.

2003-01-01

As part of the overall goal of developing Integrated Vehicle Health Management (IVHM) systems for aerospace vehicles, NASA has focused considerable resources on the development of technologies for Structural Health Management (SHM). The motivations for these efforts are to increase the safety and reliability of aerospace structural systems, while at the same time decreasing operating and maintenance costs. Research and development of SHM technologies has been supported under a variety of programs for both aircraft and spacecraft including the Space Launch Initiative, X-33, Next Generation Launch Technology, and Aviation Safety Program. The major focus of much of the research to date has been on the development and testing of sensor technologies. A wide range of sensor technologies are under consideration including fiber-optic sensors, active and passive acoustic sensors, electromagnetic sensors, wireless sensing systems, MEMS, and nanosensors. Because of their numerous advantages for aerospace applications, most notably being extremely light weight, fiber-optic sensors are one of the leading candidates and have received considerable attention.

Enrichment of target sequences for next-generation sequencing applications in research and diagnostics.

PubMed

Altmüller, Janine; Budde, Birgit S; Nürnberg, Peter

2014-02-01

Abstract Targeted re-sequencing such as gene panel sequencing (GPS) has become very popular in medical genetics, both for research projects and in diagnostic settings. The technical principles of the different enrichment methods have been reviewed several times before; however, new enrichment products are constantly entering the market, and researchers are often puzzled about the requirement to take decisions about long-term commitments, both for the enrichment product and the sequencing technology. This review summarizes important considerations for the experimental design and provides helpful recommendations in choosing the best sequencing strategy for various research projects and diagnostic applications.

Emotion Generation and Emotion Regulation: One or Two Depends on Your Point of View

PubMed Central

Gross, James J.; Barrett, Lisa Feldman

2010-01-01

Emotion regulation has the odd distinction of being a wildly popular construct whose scientific existence is in considerable doubt. In this article, we discuss the confusion about whether emotion generation and emotion regulation can and should be distinguished from one another. We describe a continuum of perspectives on emotion, and highlight how different (often mutually incompatible) perspectives on emotion lead to different views about whether emotion generation and emotion regulation can be usefully distinguished. We argue that making differences in perspective explicit serves the function of allowing researchers with different theoretical commitments to collaborate productively despite seemingly insurmountable differences in terminology and methods. PMID:21479078

The Overwhelmed Generation and Foreign Language Teacher Preparation: Developing Strategies to Work with the Mental Health Challenges of Preservice Teachers

ERIC Educational Resources Information Center

Schrier, Leslie L.

2008-01-01

For the last two decades the foreign language education profession has spent considerable energy establishing professional guidelines for foreign language teacher preparation. This article discusses research that suggests that the profession should now direct its energies toward developing protocols to assist preservice teachers whose mental…

Determinants of Moral Reasoning: Academic Factors, Gender, Richness-of-Life Experiences, and Religious Preferences

ERIC Educational Resources Information Center

Wilhelm, William J.

2004-01-01

A series of initiatives over the last fifteen years have helped forge today's consensus on the need to clarify and clearly communicate standards of behavior (National Skills Standards Board (NSSB), 1996). These initiatives have generated considerable discourse and subsequent research dealing with morals and ethics. This study focuses on academic,…

Influence of Learning Styles on Social Structures in Online Learning Environments

ERIC Educational Resources Information Center

Cela, Karina; Sicilia, Miguel-Ángel; Sánchez-Alonso, Salvador

2016-01-01

In e-learning settings, the interactions of students with one another, with the course content and with the instructors generate a considerable amount of information that may be useful for understanding how people learn online. The objective of the present research was to use social network analysis to explore the social structure of an e-learning…

Engineering Concepts: The Interplay between Concept Formation and Modeling Practices in Bioengineering Sciences

ERIC Educational Resources Information Center

Nersessian, Nancy J.

2012-01-01

As much research has demonstrated, novel scientific concepts do not arise fully formed in the head of a scientist but are created in problem-solving processes, which can extend for considerable periods and even span generations of scientists. To understand concept formation and conceptual change it is important to investigate these processes in…

New thermodynamics of entropy generation minimization with nonlinear thermal radiation and nanomaterials

NASA Astrophysics Data System (ADS)

Hayat, T.; Khan, M. Ijaz; Qayyum, Sumaira; Alsaedi, A.; Khan, M. Imran

2018-03-01

This research addressed entropy generation for MHD stagnation point flow of viscous nanofluid over a stretching surface. Characteristics of heat transport are analyzed through nonlinear radiation and heat generation/absorption. Nanoliquid features for Brownian moment and thermophoresis have been considered. Fluid in the presence of constant applied inclined magnetic field is considered. Flow problem is mathematically modeled and governing expressions are changed into nonlinear ordinary ones by utilizing appropriate transformations. The effects of pertinent variables on velocity, nanoparticle concentration and temperature are discussed graphically. Furthermore Brownian motion and thermophoresis effects on entropy generation and Bejan number have been examined. Total entropy generation is inspected through various flow variables. Consideration is mainly given to the convergence process. Velocity, temperature and mass gradients at the surface of sheet are calculated numerically.

[Contribution of animal experimentation to pharmacology].

PubMed

Sassard, Jean; Hamon, Michel; Galibert, Francis

2009-11-01

Animal experimentation is of considerable importance in pharmacology and cannot yet be avoided when studying complex, highly integrated physiological functions. The use of animals has been drastically reduced in the classical phases of pharmacological research, for example when comparing several compounds belonging to the same pharmacological class. However, animal experiments remain crucial for generating and validating new therapeutic concepts. Three examples of such research, conducted in strict ethical conditions, will be used to illustrate the different ways in which animal experimentation has contributed to human therapeutics.

Onboard Inert Gas Generation System/Onboard Oxygen Gas Generation System (OBIGGS/OBOGS) Study. Part 1; Aircraft System Requirements

NASA Technical Reports Server (NTRS)

Reynolds, Thomas L.; Bailey, Delbert B.; Lewinski, Daniel F.; Roseburg, Conrad M.; Palaszewski, Bryan (Technical Monitor)

2001-01-01

The purpose of this technology assessment is to define a multiphase research study program investigating Onboard Inert Gas Generation Systems (OBIGGS) and Onboard Oxygen Generation Systems (OBOGS) that would identify current airplane systems design and certification requirements (Subtask 1); explore state-of-the-art technology (Subtask 2); develop systems specifications (Subtask 3); and develop an initial system design (Subtask 4). If feasible, consideration may be given to the development of a prototype laboratory test system that could potentially be used in commercial transport aircraft (Subtask 5). These systems should be capable of providing inert nitrogen gas for improved fire cargo compartment fire suppression and fuel tank inerting and emergency oxygen for crew and passenger use. Subtask I of this research study, presented herein, defines current production aircraft certification requirements and design objectives necessary to meet mandatory FAA certification requirements and Boeing design and performance specifications. These requirements will be utilized for baseline comparisons for subsequent OBIGGS/OBOGS application evaluations and assessments.

Behavioral headache research: methodologic considerations and research design alternatives.

PubMed

Hursey, Karl G; Rains, Jeanetta C; Penzien, Donald B; Nash, Justin M; Nicholson, Robert A

2005-05-01

Behavioral headache treatments have garnered solid empirical support in recent years, but there is substantial opportunity to strengthen the next generation of studies with improved methods and consistency across studies. Recently, Guidelines for Trials of Behavioral Treatments for Recurrent Headache were published to facilitate the production of high-quality research. The present article compliments the guidelines with a discussion of methodologic and research design considerations. Since there is no research design that is applicable in every situation, selecting an appropriate research design is fundamental to producing meaningful results. Investigators in behavioral headache and other areas of research consider the developmental phase of the research, the principle objectives of the project, and the sources of error or alternative interpretations in selecting a design. Phases of clinical trials typically include pilot studies, efficacy studies, and effectiveness studies. These trials may be categorized as primarily pragmatic or explanatory. The most appropriate research designs for these different phases and different objectives vary on such characteristics as sample size and assignment to condition, types of control conditions, periods or frequency of measurement, and the dimensions along which comparisons are made. A research design also must fit within constraints on available resources. There are a large number of potential research designs that can be used and considering these characteristics allows selection of appropriate research designs.

Recent progress in nanostructured next-generation field emission devices

NASA Astrophysics Data System (ADS)

Mittal, Gaurav; Lahiri, Indranil

2014-08-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40-50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices.

Evaluating the Financial Vulnerability of a Major Electric Utility in the Southeastern U.S. to Drought under Climate Change and an Evolving Generation Mix.

PubMed

Kern, Jordan D; Characklis, Gregory W

2017-08-01

There is increasing recognition of the vulnerability of electric power systems to drought and the potential for both climate change and a shifting generation mix to alter this vulnerability. Nonetheless, the considerable research in this area has not been synthesized to inform electric utilities with respect to a key factor that influences their decisions about critical infrastructure: financial risk for shareholders. This study addresses this gap in knowledge by developing a systems framework for assessing the financial exposure of utilities to drought, with further consideration of the effects of climate change and a shifting generation mix. We then apply this framework to a major utility in the Southeastern U.S. Results suggest that extreme drought could cause profit shortfalls of more than $100 million if water temperature regulations are strictly enforced. However, even losses of this magnitude would not significantly impact returns for shareholders. This may inadvertently reduce pressure internally at utilities to incorporate drought vulnerability into long-term strategic planning, potentially leaving utilities and their customers at greater risk in the future.

How Activism Features in the Career Lives of Four Generations of Canadian Nurses.

PubMed

MacDonnell, Judith A; Buck-McFadyen, Ellen

2016-11-01

Recent nursing research using a critical feminist lens challenges the prevailing view of political inertia in nursing. This comparative life history study using a critical feminist lens explores the relevance of activism with four generations of Canadian nurses. Purposeful sampling of Ontario nurses resulted in 40 participants who were diverse in terms of generation, practice setting, and activist practice. Interviews and focus groups were completed with the sample of Ontario registered nurses or undergraduate and graduate nursing students: 8 Generation X, 9 Generation Y (Millennials), 20 Boomers, and 3 Overboomers. Factors such as professional norms and personal and organizational supports shaped contradictory nursing activist identities, practices, and impacts. Gendered norms, organizational dynamics, and the political landscape influenced the meanings nurses attributed to critical incidents and influences that prompted activism inside and outside the workplace, shaping the transformative potential of nursing. Despite its limitations, the study has implications for creating professional and organizational supports for consideration of health politics and policy, and spaces for dialogue to support practice and research aligned with social justice goals.

The 'Self' and Borderline Personality Disorder: Conceptual and Clinical Considerations.

PubMed

Kerr, Ian B; Finlayson-Short, Laura; McCutcheon, Louise K; Beard, Hilary; Chanen, Andrew M

2015-01-01

Some concept of self has been used by many, although not all, researchers and clinicians as an 'organising construct' for borderline personality disorder (BPD). There is considerable variation in this usage and how clearly researchers have defined the self. Given this diversity, and that 'self' is often used interchangeably with parallel concepts (e.g., psyche, brain-mind, 'person') or with features of self (e.g., self-awareness, identity), unqualified use of the term is problematic. This is further complicated by the heterogeneity and 'comorbidity' of BPD and the limitations of syndromally based psychiatric nosology. Still, BPD remains in current classification systems and can be reliably diagnosed. A considerable body of research on self and BPD has accrued, including a recent profusion and confluence of neuroscientific and sociopsychological findings. These have generated supporting evidence for a supra-ordinate, functionally constituted entity of the self ranging over multiple, interacting levels from an unconscious, 'core' self, through to a reflective, phenotypic, 'idiographic' and relational self constituted by interpersonal and sociocultural experience. Important insights have been generated regarding emotional and social-cognitive dysregulation, disorder of self-awareness, relationality, identity, and coherence and continuity of the self. Many of these are shared by various trauma-related, dissociative disorders. A construct of the self could be useful as an explanatory principle in BPD, which could be construed as a 'self-state' (and relational) disorder, as opposed to a less severe disorder of aspects of the self (e.g., mood or memory). We offer a tentative description of 'Self' in this context, noting that any such construct will require a clear definition and to be evaluable. © 2015 S. Karger AG, Basel.

"It's Pretty Cool to Be Clever": The Marginal Relevance of Gender to Educational Practices and Attainment at A/AS Level?

ERIC Educational Resources Information Center

Kettley, Nigel

2006-01-01

Gender differences in educational attainment have generated considerable debate. Unfortunately, this debate has been constructed in terms of either the measurement of change in the size of the gender gap over time or attempts to theorise such change. This scholarly divide reflects the commitment of researchers to particular methodological…

Estimating Demand for Higher Education Services. Planning for Higher Education; Vol. 3; No. 3; June 1974.

ERIC Educational Resources Information Center

Kicinski, Walter T.; Soss, Neal M.

Changing patterns of demand for higher education services have generated considerable interest in research into the factors governing the choices students make when they apply to colleges and universities. During 1973, the staff of the State Budget Division of New York State undertook the task of creating a general model of the demand for college…

'The Trouble with Normal': (Re)Imagining Sexuality Education with Young People

ERIC Educational Resources Information Center

Coll, Leanne; O'Sullivan, Mary; Enright, Eimear

2018-01-01

What do young people believe sexuality education ought to be about? It is within the absence of a sustained and critical consideration of the possibilities and politics of engaging in research with rather than for young people in the reimagining of sexuality education that this paper is positioned. Data were generated as part of an 18-month Youth…

Risk factors for asthma and timing of exposure among first generation Arab immigrants: a pilot effort to elucidate the role of exposure to risk factors over multiple life stages

EPA Science Inventory

Considerable controversy exists over the role of aero-allergens in asthma etiology. Some studies show increased risk with microbe and allergen exposure, while others show decreased risk. These discrepancies may be explained by timing of exposure. Previous research suggests that e...

Next-generation sequencing for endocrine cancers: Recent advances and challenges.

PubMed

Suresh, Padmanaban S; Venkatesh, Thejaswini; Tsutsumi, Rie; Shetty, Abhishek

2017-05-01

Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.

Mobile and Wireless Technologies in Health Behavior and the Potential for Intensively Adaptive Interventions.

PubMed

Riley, William T; Serrano, Katrina J; Nilsen, Wendy; Atienza, Audie A

2015-10-01

Recent advances in mobile and wireless technologies have made real-time assessments of health behaviors and their influences possible with minimal respondent burden. These tech-enabled real-time assessments provide the basis for intensively adaptive interventions (IAIs). Evidence of such studies that adjust interventions based on real-time inputs is beginning to emerge. Although IAIs are promising, the development of intensively adaptive algorithms generate new research questions, and the intensive longitudinal data produced by IAIs require new methodologies and analytic approaches. Research considerations and future directions for IAIs in health behavior research are provided.

Microbial-Catalyzed Biotransformation of Multifunctional Triterpenoids Derived from Phytonutrients

PubMed Central

Shah, Syed Adnan Ali; Tan, Huey Ling; Sultan, Sadia; Mohd Faridz, Muhammad Afifi Bin; Mohd Shah, Mohamad Azlan Bin; Nurfazilah, Sharifah; Hussain, Munawar

2014-01-01

Microbial-catalyzed biotransformations have considerable potential for the generation of an enormous variety of structurally diversified organic compounds, especially natural products with complex structures like triterpenoids. They offer efficient and economical ways to produce semi-synthetic analogues and novel lead molecules. Microorganisms such as bacteria and fungi could catalyze chemo-, regio- and stereospecific hydroxylations of diverse triterpenoid substrates that are extremely difficult to produce by chemical routes. During recent years, considerable research has been performed on the microbial transformation of bioactive triterpenoids, in order to obtain biologically active molecules with diverse structures features. This article reviews the microbial modifications of tetranortriterpenoids, tetracyclic triterpenoids and pentacyclic triterpenoids. PMID:25003642

Emerging uses of patient generated health data in clinical research.

PubMed

Wood, William A; Bennett, Antonia V; Basch, Ethan

2015-05-01

Recent advancements in consumer directed personal computing technology have led to the generation of biomedically-relevant data streams with potential health applications. This has catalyzed international interest in Patient Generated Health Data (PGHD), defined as "health-related data - including health history, symptoms, biometric data, treatment history, lifestyle choices, and other information-created, recorded, gathered, or inferred by or from patients or their designees (i.e. care partners or those who assist them) to help address a health concern."(Shapiro et al., 2012) PGHD offers several opportunities to improve the efficiency and output of clinical trials, particularly within oncology. These range from using PGHD to understand mechanisms of action of therapeutic strategies, to understanding and predicting treatment-related toxicity, to designing interventions to improve adherence and clinical outcomes. To facilitate the optimal use of PGHD, methodological research around considerations related to feasibility, validation, measure selection, and modeling of PGHD streams is needed. With successful integration, PGHD can catalyze the application of "big data" to cancer clinical research, creating both "n of 1" and population-level observations, and generating new insights into the nature of health and disease. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Using global unique identifiers to link autism collections.

PubMed

Johnson, Stephen B; Whitney, Glen; McAuliffe, Matthew; Wang, Hailong; McCreedy, Evan; Rozenblit, Leon; Evans, Clark C

2010-01-01

To propose a centralized method for generating global unique identifiers to link collections of research data and specimens. The work is a collaboration between the Simons Foundation Autism Research Initiative and the National Database for Autism Research. The system is implemented as a web service: an investigator inputs identifying information about a participant into a client application and sends encrypted information to a server application, which returns a generated global unique identifier. The authors evaluated the system using a volume test of one million simulated individuals and a field test on 2000 families (over 8000 individual participants) in an autism study. Inverse probability of hash codes; rate of false identity of two individuals; rate of false split of single individual; percentage of subjects for which identifying information could be collected; percentage of hash codes generated successfully. Large-volume simulation generated no false splits or false identity. Field testing in the Simons Foundation Autism Research Initiative Simplex Collection produced identifiers for 96% of children in the study and 77% of parents. On average, four out of five hash codes per subject were generated perfectly (only one perfect hash is required for subsequent matching). The system must achieve balance among the competing goals of distinguishing individuals, collecting accurate information for matching, and protecting confidentiality. Considerable effort is required to obtain approval from institutional review boards, obtain consent from participants, and to achieve compliance from sites during a multicenter study. Generic unique identifiers have the potential to link collections of research data, augment the amount and types of data available for individuals, support detection of overlap between collections, and facilitate replication of research findings.

An exploratory comparison of name generator content: Data from rural India.

PubMed

Shakya, Holly B; Christakis, Nicholas A; Fowler, James H

2017-01-01

Since the 1970s sociologists have explored the best means for measuring social networks, although few name generator analyses have used sociocentric data or data from developing countries, partly because sociocentric studies in developing countries have been scant. Here, we analyze 12 different name generators used in a sociocentric network study conducted in 75 villages in rural Karnataka, India. Having unusual sociocentric data from a non-Western context allowed us to extend previous name generator research through the unique analyses of network structural measures, an extensive consideration of homophily, and investigation of status difference between egos and alters. We found that domestic interaction questions generated networks that were highly clustered and highly centralized. Similarity between respondents and their nominated contacts was strongest for gender, caste, and religion. We also found that domestic interaction name generators yielded the most homogeneous ties, while advice questions yielded the most heterogeneous. Participants were generally more likely to nominate those of higher social status, although certain questions, such as who participants talk to uncovered more egalitarian relationships, while other name generators elicited the names of social contacts distinctly higher or lower in status than the respondent. Some questions also seemed to uncover networks that were specific to the cultural context, suggesting that network researchers should balance local relevance with global generalizability when choosing name generators.

The ethics of research using electronic mail discussion groups.

PubMed

Kralik, Debbie; Warren, Jim; Price, Kay; Koch, Tina; Pignone, Gino

2005-12-01

The aim of this paper is to identify and discuss the ethical considerations that have confronted and challenged the research team when researchers facilitate conversations using private electronic mail discussion lists. The use of electronic mail group conversations, as a collaborative data generation method, remains underdeveloped in nursing. Ethical challenges associated with this approach to data generation have only begun to be considered. As receipt of ethics approval for a study titled; 'Describing transition with people who live with chronic illness' we have been challenged by many ethical dilemmas, hence we believe it is timely to share the issues that have confronted the research team. These discussions are essential so we can understand the possibilities for research interaction, communication, and collaboration made possible by advanced information technologies. Our experiences in this study have increased our awareness for ongoing ethical discussions about privacy, confidentiality, consent, accountability and openness underpinning research with human participants when generating data using an electronic mail discussion group. We describe how we work at upholding these ethical principles focusing on informed consent, participant confidentiality and privacy, the participants as threats to themselves and one another, public-private confusion, employees with access, hackers and threats from the researchers. A variety of complex issues arise during cyberspace research that can make the application of traditional ethical standards troublesome. Communication in cyberspace alters the temporal, spatial and sensory components of human interaction, thereby challenging traditional ethical definitions and calling to question some basic assumptions about identity and ones right to keep aspects of it confidential. Nurse researchers are bound by human research ethics protocols; however, the nature of research by electronic mail generates moral issues as well as ethical concerns. Vigilance by researchers is required to ensure that data are viewed within the scope of the enabling ethics approval.

Contributions of leisure studies and recreation and park management research to the active living agenda.

PubMed

Godbey, Geoffrey C; Caldwell, Linda L; Floyd, Myron; Payne, Laura L

2005-02-01

Although the fields of leisure studies and recreation and parks were founded on addressing health and wellness needs of people, only recently have these needs been addressed by major, systematic research efforts. This paper examines the origins of leisure studies and the study of recreation behavior and park use and their potential contribution to active living research. Over the past 2 decades, leisure studies research has generated a body of literature pertinent to understanding and increasing active living, including studies on time use, motivation for initiating and maintaining activity, influence of user fees, and urban park use. Environmental, transportation, and public recreation policy and management practices also are important considerations in recreation and parks research. This article concludes with a list of recommendations to integrate these and other considerations into transdisciplinary research on active living. Opportunities for leisure studies/recreation and park research on active living include studies of environmental, life span, and motivational influences; greater use of objective measures of physical activity; and forming partnerships with allied industries to study physical activity. Among suggestions for facilitating such studies are training seminars for leisure studies and recreation researchers in active living research methods, changes in point allocation on grant proposals, providing incentives for transdisciplinary collaboration, and special journal issues.

What is the role of culture, diversity, and community engagement in transdisciplinary translational science?

PubMed

Graham, Phillip W; Kim, Mimi M; Clinton-Sherrod, A Monique; Yaros, Anna; Richmond, Alan N; Jackson, Melvin; Corbie-Smith, Giselle

2016-03-01

Concepts of culture and diversity are necessary considerations in the scientific application of theory generation and developmental processes of preventive interventions; yet, culture and/or diversity are often overlooked until later stages (e.g., adaptation [T3] and dissemination [T4]) of the translational science process. Here, we present a conceptual framework focused on the seamless incorporation of culture and diversity throughout the various stages of the translational science process (T1-T5). Informed by a community-engaged research approach, this framework guides integration of cultural and diversity considerations at each phase with emphasis on the importance and value of "citizen scientists" being research partners to promote ecological validity. The integrated partnership covers the first phase of intervention development through final phases that ultimately facilitate more global, universal translation of changes in attitudes, norms, and systems. Our comprehensive model for incorporating culture and diversity into translational research provides a basis for further discussion and translational science development.

Introduction to SIMRAND: Simulation of research and development project

NASA Technical Reports Server (NTRS)

Miles, R. F., Jr.

1982-01-01

SIMRAND: SIMulation of Research ANd Development Projects is a methodology developed to aid the engineering and management decision process in the selection of the optimal set of systems or tasks to be funded on a research and development project. A project may have a set of systems or tasks under consideration for which the total cost exceeds the allocated budget. Other factors such as personnel and facilities may also enter as constraints. Thus the project's management must select, from among the complete set of systems or tasks under consideration, a partial set that satisfies all project constraints. The SIMRAND methodology uses analytical techniques and probability theory, decision analysis of management science, and computer simulation, in the selection of this optimal partial set. The SIMRAND methodology is truly a management tool. It initially specifies the information that must be generated by the engineers, thus providing information for the management direction of the engineers, and it ranks the alternatives according to the preferences of the decision makers.

Building the Partners HealthCare Biobank at Partners Personalized Medicine: Informed Consent, Return of Research Results, Recruitment Lessons and Operational Considerations

PubMed Central

Karlson, Elizabeth W.; Boutin, Natalie T.; Hoffnagle, Alison G.; Allen, Nicole L.

2016-01-01

The Partners HealthCare Biobank is a Partners HealthCare enterprise-wide initiative whose goal is to provide a foundation for the next generation of translational research studies of genotype, environment, gene-environment interaction, biomarker and family history associations with disease phenotypes. The Biobank has leveraged in-person and electronic recruitment methods to enroll >30,000 subjects as of October 2015 at two academic medical centers in Partners HealthCare since launching in 2010. Through a close collaboration with the Partners Human Research Committee, the Biobank has developed a comprehensive informed consent process that addresses key patient concerns, including privacy and the return of research results. Lessons learned include the need for careful consideration of ethical issues, attention to the educational content of electronic media, the importance of patient authentication in electronic informed consent, the need for highly secure IT infrastructure and management of communications and the importance of flexible recruitment modalities and processes dependent on the clinical setting for recruitment. PMID:26784234

Large-scale-system effectiveness analysis. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patton, A.D.; Ayoub, A.K.; Foster, J.W.

1979-11-01

Objective of the research project has been the investigation and development of methods for calculating system reliability indices which have absolute, and measurable, significance to consumers. Such indices are a necessary prerequisite to any scheme for system optimization which includes the economic consequences of consumer service interruptions. A further area of investigation has been joint consideration of generation and transmission in reliability studies. Methods for finding or estimating the probability distributions of some measures of reliability performance have been developed. The application of modern Monte Carlo simulation methods to compute reliability indices in generating systems has been studied.

Next Generation Mesenchymal Stem Cell (MSC)–Based Cartilage Repair Using Scaffold-Free Tissue Engineered Constructs Generated with Synovial Mesenchymal Stem Cells

PubMed Central

Shimomura, Kazunori; Ando, Wataru; Moriguchi, Yu; Sugita, Norihiko; Yasui, Yukihiko; Koizumi, Kota; Fujie, Hiromichi; Hart, David A.; Yoshikawa, Hideki

2015-01-01

Because of its limited healing capacity, treatments for articular cartilage injuries are still challenging. Since the first report by Brittberg, autologous chondrocyte implantation has been extensively studied. Recently, as an alternative for chondrocyte-based therapy, mesenchymal stem cell–based therapy has received considerable research attention because of the relative ease in handling for tissue harvest, and subsequent cell expansion and differentiation. This review summarizes latest development of stem cell therapies in cartilage repair with special attention to scaffold-free approaches. PMID:27340513

Recommendations for ethical approaches to genotype-driven research recruitment

PubMed Central

Beskow, Laura M.; Fullerton, Stephanie M.; Namey, Emily E.; Nelson, Daniel K.; Davis, Arlene M.; Wilfond, Benjamin S.

2013-01-01

Recruiting research participants based on genetic information generated about them in a prior study is a potentially powerful way to study the functional significance of human genetic variation. However, it also presents significant ethical challenges that, to date, have received only minimal consideration. We convened a multi-disciplinary workshop to discuss key issues relevant to the conduct and oversight of genotype-driven recruitment and to translate those considerations into practical policy recommendations. Workshop participants were invited from around the U.S., and included genomic researchers and study coordinators, research participants, clinicians, bioethics scholars, experts in human research protections, and government representatives. Discussion was directed by experienced facilitators and informed by empirical data collected in a national survey of IRB chairs and in-depth interviews with research participants in studies where genotype-driven recontact occurred. A high degree of consensus was attained on the resulting 7 recommendations, which cover informed consent disclosures and choices, the process for how and by whom participants are recontacted, the disclosure of individual genetic research results, and the importance of tailoring approaches based on specific contextual factors. These recommendations are intended to represent a balanced approach—protecting research participants, yet avoiding overly restrictive policies that hinder advancement on important scientific questions. PMID:22622788

Substitute consent to data sharing: a way forward for international dementia research?

PubMed Central

Thorogood, Adrian; Deschênes St-Pierre, Constance; Knoppers, Bartha Maria

2017-01-01

Abstract A deluge of genetic and health-related data is being generated about patients with dementia. International sharing of these data accelerates dementia research. Seeking consent to data sharing is a challenge for dementia research where patients have lost or risk losing legal capacity. The laws of most countries enable substitute decision makers (SDMs) to consent on behalf of incapable adults to research participation. We compare regulatory frameworks governing capacity, research, and personal data protection across eight countries to determine when SDMs can consent to data sharing. In most countries, an SDM can consent to data sharing in the incapable adult's best interests. Best interests typically include consideration of the individual's previously expressed wishes, values and beliefs; well-being; and inclusion in decision making. Countries differ in how these considerations are balanced. A clear previous consent or refusal to share data typically binds the discretion of an SDM. Though generally permissive, National patchworks of laws and guidelines cause confusion. Clarity on the applicable law and processes to enhance ethical decision making are needed to facilitate substitute consent. Researchers can encourage patients to communicate their research preferences before a loss of capacity, and educate SDMs about their ethical and legal duties. The research community must also continue to promote the importance of data sharing in dementia. PMID:28852560

Clinical research in small genomically stratified patient populations.

PubMed

Martin-Liberal, J; Rodon, J

2017-07-01

The paradigm of early drug development in cancer is shifting from 'histology-oriented' to 'molecularly oriented' clinical trials. This change can be attributed to the vast amount of tumour biology knowledge generated by large international research initiatives such as The Cancer Genome Atlas (TCGA) and the use of next generation sequencing (NGS) techniques developed in recent years. However, targeting infrequent molecular alterations entails a series of special challenges. The optimal molecular profiling method, the lack of standardised biological thresholds, inter- and intra-tumor heterogeneity, availability of enough tumour material, correct clinical trials design, attrition rate, logistics or costs are only some of the issues that need to be taken into consideration in clinical research in small genomically stratified patient populations. This article examines the most relevant challenges inherent to clinical research in these populations. Moreover, perspectives from the Academia point of view are reviewed as well as initiatives to be taken in forthcoming years. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal

PubMed Central

Hawkes, Jason E.; Gudjonsson, Johann E.; Ward, Nicole L.

2016-01-01

Since 2009, the imiquimod- or Aldara-induced (3M Pharmaceuticals, St. Paul, MN) model of acute skin inflammation has become the most widely used mouse model in preclinical psoriasis studies. Although this model offers researchers numerous benefits, there are important limitations and possible confounding variables to consider. The imiquimod model requires careful consideration and warrants scrutiny of the data generated by its use. In this perspective, we provide an overview of the advantages and disadvantages of this mouse model and offer suggestions for its use in psoriasis research. PMID:27955901

Research progress of infrared detecting and display integrated device based on infrared-visible up-conversion technology

NASA Astrophysics Data System (ADS)

Xu, Junfeng; Li, Weile; He, Bo; Wang, Haowei; Song, Yong; Yang, Shengyi; Ni, Guoqiang

2018-01-01

Infrared detecting and display device (IR-DDD) is a newly developed optical up-conversion device that integrates the light-emitting diode (LED) onto the infrared (IR) photo-detector, in order to convert IR light into the carriers photo-generated in detection materials and inject them into LED to emit visible light. This IR-DDD can achieve the direct up-conversion from IR ray to visible light, showing the considerable potential in night-vision application. This paper attempts a review of its working principle and current research progresses.

Funding of pilot projects in Latin America: a tool for capacity building in occupational health research.

PubMed

Felknor, Sarah A; Delclos, George L; Gimeno, David; Wesseling, Ineke; Monge, Patricia; Chavez, Jorge; Quintana, Leonardo; Schulze, Lawrence J H

2006-01-01

There is a global need for trained researchers who can address the increasing burden of illness and injury and prepare future generations of researchers. Developing countries have a special need for practical, action-oriented interventions to address workplace problems, based on identification of needs and priorities, development of locally available solutions, and consideration of the sociopolitical context of work and how best to translate research findings into policies. Effective translation and application of research products from industrialized nations to developing countries is essential, but differences in the contexts and local realities of other nations limit extrapolating such research. Funding pilot research projects in developing countries is an effective, practical, and useful tool for training new investigators in research techniques and developing collaborative relationships among countries.

2nd Generation Reusable Launch Vehicle Potential Commercial Development Scenarios

NASA Technical Reports Server (NTRS)

Creech, Stephen D.; Rogacki, John R. (Technical Monitor)

2001-01-01

The presentation will discuss potential commercial development scenarios for a Second Generation Reusable Launch Vehicle. The analysis of potential scenarios will include commercial rates of return, government return on investment, and market considerations. The presentation will include policy considerations in addition to analysis of Second Generation Reusable Launch Vehicle economics. The data discussed is being developed as a part of NASA's Second Generation Reusable Launch Vehicle Program, for consideration as potential scenarios for enabling a next generation system. Material will include potential scenarios not previously considered by NASA or presented at other conferences. Candidate paper has not been presented at a previous meeting, and conference attendance of the author has been approved by NASA.

Promoting research participation: why not advertise altruism?

PubMed

Williams, Brian; Entwistle, Vikki; Haddow, Gill; Wells, Mary

2008-04-01

Participation rates have a major impact on the quality, cost and timeliness of health research. There is growing evidence that participation rates may be falling and that new research governance structures and procedures may be increasing the likelihood of recruitment bias. It may be possible to encourage public reflection about research participation and enhance recruitment by providing information about the potential benefits of research to others as well as to research participants and by stimulating debate and influencing social expectations about involvement. Publicly funded and charitable bodies use various forms of advertising to encourage altruistic behaviour and generate social expectations about donating money, blood and organs for the benefit of others. Consideration should be given to the use of similar persuasive communications to promote wider participation in health research generally.

Flow Distribution Control Characteristics in Marine Gas Turbine Waste- Heat Recovery Systems. Phase 2. Flow Distribution Control in Waste-Heat Steam Generators

DTIC Science & Technology

1982-07-01

waste-heat steam generators. The applicable steam generator design concepts and general design consideration were reviewed and critical problems...a once-through forced-circulation steam generator design should be selected because of stability, reliability, compact- ness and lightweight...consists of three sections and one appendix. In Section I, the applicable steam generator design conccpts and general design * considerations are reviewed

Design of siRNA Therapeutics from the Molecular Scale

PubMed Central

Angart, Phillip; Vocelle, Daniel; Chan, Christina; Walton, S. Patrick

2013-01-01

While protein-based therapeutics is well-established in the market, development of nucleic acid therapeutics has lagged. Short interfering RNAs (siRNAs) represent an exciting new direction for the pharmaceutical industry. These small, chemically synthesized RNAs can knock down the expression of target genes through the use of a native eukaryotic pathway called RNA interference (RNAi). Though siRNAs are routinely used in research studies of eukaryotic biological processes, transitioning the technology to the clinic has proven challenging. Early efforts to design an siRNA therapeutic have demonstrated the difficulties in generating a highly-active siRNA with good specificity and a delivery vehicle that can protect the siRNA as it is transported to a specific tissue. In this review article, we discuss design considerations for siRNA therapeutics, identifying criteria for choosing therapeutic targets, producing highly-active siRNA sequences, and designing an optimized delivery vehicle. Taken together, these design considerations provide logical guidelines for generating novel siRNA therapeutics. PMID:23976875

UTSG-2; A theoretical model describing the transient behavior of a pressurized water reactor natural circulation U-tube steam generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hold, A.

An advanced nonlinear transient model for calculating steady-state and dynamic behaviors of characteristic parameters of a Kraftwerk Union-type vertical natural-circulation U-tube steam generator and its main steam system is presented. This model has been expanded due to the increasing need for safety-related accident research studies. It now takes into consideration the possibilities of dryout and superheating along the secondary side of the steam generator. The resulting theoretical model is the basis of the digital code UTSG-2, which can be used both by itself and in combination with other pressurized water reactor transient codes, such as ALMOD-3.4, AMOD-4, and ATHLET.

Germline genome-editing research and its socioethical implications.

PubMed

Ishii, Tetsuya

2015-08-01

Genetically modifying eggs, sperm, and zygotes ('germline' modification) can impact on the entire body of the resulting individual and on subsequent generations. With the advent of genome-editing technology, human germline gene modification is no longer theoretical. Owing to increasing concerns about human germline gene modification, a voluntary moratorium on human genome-editing research and/or the clinical application of human germline genome editing has recently been called for. However, whether such research should be suspended or encouraged warrants careful consideration. The present article reviews recent research on mammalian germline genome editing, discusses the importance of public dialogue on the socioethical implications of human germline genome-editing research, and considers the relevant guidelines and legislation in different countries. Copyright © 2015 Elsevier Ltd. All rights reserved.

Monitoring and control requirement definition study for Dispersed Storage and Generation (DSG). Volume 5, appendix D: Cost-benefit considerations for providing dispersed storage and generation for electric utilities

NASA Technical Reports Server (NTRS)

1980-01-01

Cost benefit considerations are extremely important in obtaining the acceptance of dispersed storage and generation (DSG) by the electric utilities. These considerations involved somewhat different economic analyses depending on whether the generation is utility, customer, or combined ownership. It is necessary to get acceptance of more easily understood methods for evaluating the economics of DSG because much of the benefits of DSG may accrue in the generation and transmission portions of the utility system while the costs tend to be centered in the distribution portion of that system. The influence of factors, such as reliability, capital costs, and other economic measures were also investigated.

Critical review: Uncharted waters? The future of the electricity-water nexus.

PubMed

Sanders, Kelly T

2015-01-06

Electricity generation often requires large amounts of water, most notably for cooling thermoelectric power generators and moving hydroelectric turbines. This so-called "electricity-water nexus" has received increasing attention in recent years by governments, nongovernmental organizations, industry, and academics, especially in light of increasing water stress in many regions around the world. Although many analyses have attempted to project the future water requirements of electricity generation, projections vary considerably due to differences in temporal and spatial boundaries, modeling frameworks, and scenario definitions. This manuscript is intended to provide a critical review of recent publications that address the future water requirements of electricity production and define the factors that will moderate the water requirements of the electric grid moving forward to inform future research. The five variables identified include changes in (1) fuel consumption patterns, (2) cooling technology preferences, (3) environmental regulations, (4) ambient climate conditions, and (5) electric grid characteristics. These five factors are analyzed to provide guidance for future research related to the electricity-water nexus.

The interplay of biology and technology

PubMed Central

Fields, Stanley

2001-01-01

Technologies for biological research arise in multiple ways—through serendipity, through inspired insights, and through incremental advances—and they are tightly coupled to progress in engineering. Underlying the complex dynamics of technology and biology are the different motivations of those who work in the two realms. Consideration of how methodologies emerge has implications for the planning of interdisciplinary centers and the training of the next generation of scientists. PMID:11517346

Project Report of Virtual Experiments in Marine Bioacoustics: Model Validation

DTIC Science & Technology

2010-08-01

are hypothesized to be the biosonar sound source in the bottlenose dolphin (Cranford, 2000; Cranford et al., 1996). The phonic lips consist of...generation apparatus can produce small changes or adjustments in bottlenose dolphin biosonar beam direction. There are likely more discoveries...Beam Direction Biosonar beam formation in dolphins has been the subject of considerable research (Au, 1980; Au, 1993; Au et al., 1978; Au et al

Wood and coal cofiring in Alaska—operational considerations and combustion gas effects for a grate-fired power plant

Treesearch

David Nicholls; Zackery Wright; Daisy Huang

2018-01-01

Coal is the primary fuel source for electrical power generation in interior Alaska, with more than 600,000 tons burned annually at five different power plants. Woody biomass could be used as part of this fuel mix, offering potential environmental and economic benefits. In this research, debarked chips were cofired with locally mined coal at the Aurora Power Plant...

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.

PubMed

Api, A M; Belsito, D; Bruze, M; Cadby, P; Calow, P; Dagli, M L; Dekant, W; Ellis, G; Fryer, A D; Fukayama, M; Griem, P; Hickey, C; Kromidas, L; Lalko, J F; Liebler, D C; Miyachi, Y; Politano, V T; Renskers, K; Ritacco, G; Salvito, D; Schultz, T W; Sipes, I G; Smith, B; Vitale, D; Wilcox, D K

2015-08-01

The Research Institute for Fragrance Materials, Inc. (RIFM) has been engaged in the generation and evaluation of safety data for fragrance materials since its inception over 45 years ago. Over time, RIFM's approach to gathering data, estimating exposure and assessing safety has evolved as the tools for risk assessment evolved. This publication is designed to update the RIFM safety assessment process, which follows a series of decision trees, reflecting advances in approaches in risk assessment and new and classical toxicological methodologies employed by RIFM over the past ten years. These changes include incorporating 1) new scientific information including a framework for choosing structural analogs, 2) consideration of the Threshold of Toxicological Concern (TTC), 3) the Quantitative Risk Assessment (QRA) for dermal sensitization, 4) the respiratory route of exposure, 5) aggregate exposure assessment methodology, 6) the latest methodology and approaches to risk assessments, 7) the latest alternatives to animal testing methodology and 8) environmental risk assessment. The assessment begins with a thorough analysis of existing data followed by in silico analysis, identification of 'read across' analogs, generation of additional data through in vitro testing as well as consideration of the TTC approach. If necessary, risk management may be considered. Copyright © 2014 Elsevier Ltd. All rights reserved.

Beyond research: a primer for considerations on using viral metagenomics in the field and clinic.

PubMed

Hall, Richard J; Draper, Jenny L; Nielsen, Fiona G G; Dutilh, Bas E

2015-01-01

Powered by recent advances in next-generation sequencing technologies, metagenomics has already unveiled vast microbial biodiversity in a range of environments, and is increasingly being applied in clinics for difficult-to-diagnose cases. It can be tempting to suggest that metagenomics could be used as a "universal test" for all pathogens without the need to conduct lengthy serial testing using specific assays. While this is an exciting prospect, there are issues that need to be addressed before metagenomic methods can be applied with rigor as a diagnostic tool, including the potential for incidental findings, unforeseen consequences for trade and regulatory authorities, privacy and cultural issues, data sharing, and appropriate reporting of results to end-users. These issues will require consideration and discussion across a range of disciplines, with inclusion of scientists, ethicists, clinicians, diagnosticians, health practitioners, and ultimately the public. Here, we provide a primer for consideration on some of these issues.

An exploratory comparison of name generator content: Data from rural India

PubMed Central

Shakya, Holly B.; Christakis, Nicholas A.; Fowler, James H.

2017-01-01

Since the 1970s sociologists have explored the best means for measuring social networks, although few name generator analyses have used sociocentric data or data from developing countries, partly because sociocentric studies in developing countries have been scant. Here, we analyze 12 different name generators used in a sociocentric network study conducted in 75 villages in rural Karnataka, India. Having unusual sociocentric data from a non-Western context allowed us to extend previous name generator research through the unique analyses of network structural measures, an extensive consideration of homophily, and investigation of status difference between egos and alters. We found that domestic interaction questions generated networks that were highly clustered and highly centralized. Similarity between respondents and their nominated contacts was strongest for gender, caste, and religion. We also found that domestic interaction name generators yielded the most homogeneous ties, while advice questions yielded the most heterogeneous. Participants were generally more likely to nominate those of higher social status, although certain questions, such as who participants talk to uncovered more egalitarian relationships, while other name generators elicited the names of social contacts distinctly higher or lower in status than the respondent. Some questions also seemed to uncover networks that were specific to the cultural context, suggesting that network researchers should balance local relevance with global generalizability when choosing name generators. PMID:28845086

Culture, context and community: ethical considerations for global nursing research.

PubMed

Harrowing, J N; Mill, J; Spiers, J; Kulig, J; Kipp, W

2010-03-01

High-quality research is essential for the generation of scientific nursing knowledge and the achievement of the Millennium Development Goals. However, the incorporation of Western bioethical principles in the study design may not be suitable, sufficient or relevant to participants in low-income countries and may indeed be harmful and disrespectful. Before engaging in global health studies, nurses must consider carefully the cultural and social context and values of the proposed setting in order to situate the research within the appropriate ethical framework. The purpose of this paper was to examine the ethical principles and considerations that guide health research conducted in international settings using the example of a qualitative study of Ugandan nurses and nurse-midwives by a Canadian researcher. The application of Western bioethical principles with their emphasis on autonomy fails to acknowledge the importance of relevant contextual aspects in the conduct of global research. Because ethics is concerned with how people interact and live together, it is essential that studies conducted across borders be respectful of, and congruent with, the values and needs of the community in which it occurs. The use of a communitarian ethical framework will allow nurse scientists to contribute to the elimination of inequities between those who enjoy prosperity and good health, and those who do not.

THE LEGACY OF DISADVANTAGE: MULTIGENERATIONAL NEIGHBORHOOD EFFECTS ON COGNITIVE ABILITY1

PubMed Central

Sharkey, Patrick; Elwert, Felix

2012-01-01

This study examines how the neighborhood environments experienced over multiple generations of a family influence children’s cognitive ability. Building on recent research showing strong continuity in neighborhood environments across generations of family members, we argue for a revised perspective on “neighborhood effects” that considers the ways in which the neighborhood environment in one generation may have a lingering impact on the next generation. To specify such multigenerational effects is not simply a theoretical problem, but poses considerable methodological challenges. Instead of traditional regression techniques that may obscure multigenerational effects of neighborhood disadvantage, we utilize newly developed methods designed to generate unbiased treatment effects when treatments and confounders vary over time. The results confirm a powerful link between neighborhoods and cognitive ability that extends across generations. Being raised in a high-poverty neighborhood in one generation has a substantial negative effect on child cognitive ability in the next generation. A family’s exposure to neighborhood poverty across two consecutive generations reduces child cognitive ability by more than half a standard deviation. A formal sensitivity analysis suggests that results are robust to unobserved selection bias. PMID:21932471

Current dichotomy between traditional molecular biological and omic research in cancer biology and pharmacology.

PubMed

Reinhold, William C

2015-12-10

There is currently a split within the cancer research community between traditional molecular biological hypothesis-driven and the more recent "omic" forms or research. While the molecular biological approach employs the tried and true single alteration-single response formulations of experimentation, the omic employs broad-based assay or sample collection approaches that generate large volumes of data. How to integrate the benefits of these two approaches in an efficient and productive fashion remains an outstanding issue. Ideally, one would merge the understandability, exactness, simplicity, and testability of the molecular biological approach, with the larger amounts of data, simultaneous consideration of multiple alterations, consideration of genes both of known interest along with the novel, cross-sample comparisons among cell lines and patient samples, and consideration of directed questions while simultaneously gaining exposure to the novel provided by the omic approach. While at the current time integration of the two disciplines remains problematic, attempts to do so are ongoing, and will be necessary for the understanding of the large cell line screens including the Developmental Therapeutics Program's NCI-60, the Broad Institute's Cancer Cell Line Encyclopedia, and the Wellcome Trust Sanger Institute's Cancer Genome Project, as well as the the Cancer Genome Atlas clinical samples project. Going forward there is significant benefit to be had from the integration of the molecular biological and the omic forms or research, with the desired goal being improved translational understanding and application.

A review of the use of vortex generators for mitigating shock-induced separation

NASA Astrophysics Data System (ADS)

Titchener, Neil; Babinsky, Holger

2015-09-01

This article reviews research into the potential of vortex generators to mitigate shock-induced separation. Studies ranging from those conducted in the early post-war era to those performed recently are discussed. On the basis of the investigations described in this report, it is clear that vortex generators can alleviate shock-induced boundary layer separation. Yet, it will be shown that their potential and efficiency varies considerably in practical applications. Much more success is reported in transonic test cases compared to separation induced in purely supersonic interactions. Under a variety of flow conditions, the best performance is achieved with vortex generators with a height of roughly half the boundary layer thickness and a shape similar to a swept vane. Notwithstanding this, vortex generator performance is not as consistent as it is in low-speed applications. Further work is required before vortex generators can be implemented into the design process for eliminating shock-induced separation on transonic wings and in supersonic inlets.

Power supplies and equipment for military field research: lessons from the British Service Dhaulagiri Research Expedition 2016.

PubMed

Howard, Matt; Bakker-Dyos, J; Gallagher, L; O'Hara, J P; Woods, D; Mellor, A

2018-02-01

The British Service Dhaulagiri Research Expedition (BSDMRE) took place from 27 March to 31 May 2016. The expedition involved 129 personnel, with voluntary participation in nine different study protocols. Studies were conducted in three research camps established at 3600, 4600 and 5140 m and involved taking and storing blood samples, cardiac echocardiography and investigations involving a balance plate. Research in this remote environment requires careful planning in order to provide a robust and resilient power plan. In this paper we aim to report the rationale for the choices we made in terms of power supply, the equipment used and potential military applicability. This is a descriptive account from the expedition members involved in planning and conducting the medical research. Power calculations were used to determine estimates of requirement prior to the expedition. The primary sources used to generate power were internal combustion engine (via petrol fuelled electric generators) and solar panels. Having been generated, power was stored using lithium-ion batteries. Special consideration was given to the storage of samples taken in the field, for which electric freezers and dry shippers were used. All equipment used functioned well during the expedition, with the challenges of altitude, temperature and transport all overcome due to extensive prior planning. Power was successfully generated, stored and delivered during the BSDMRE, allowing extensive medical research to be undertaken. The challenges faced and overcome are directly applicable to delivering military medical care in austere environments, and lessons learnt can help with the planning and delivery of future operations, training exercises or expeditions. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

There Are Thousands of Apps for That: Navigating Mobile Technology for Nutrition Education and Behavior.

PubMed

Hingle, Melanie; Patrick, Heather

2016-03-01

Mobile health (mHealth) is an emerging field devoted to the use of mobile and wireless devices to affect health outcomes, health care services, and health research. Despite great promise, little research has examined its effectiveness. It is the authors' view that the full potential of mHealth has yet to be realized in research and practice. This Perspective article explores when and for whom mHealth approaches are effective, strengths and limitations of commercially and academically generated apps, research design considerations, and public-private partnerships. These topics have implications for researchers and practitioners who wish to advance the science and practice of mHealth. Copyright © 2016 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Design, economic and system considerations of large wind-driven generators

NASA Technical Reports Server (NTRS)

Jorgensen, G. E.; Lotker, M.; Meier, R. C.; Brierley, D.

1976-01-01

The increased search for alternative energy sources has lead to renewed interest and studies of large wind-driven generators. This paper presents the results and considerations of such an investigation. The paper emphasizes the concept selection of wind-driven generators, system optimization, control system design, safety aspects, economic viability on electric utility systems and potential electric system interfacing problems.

The European General Data Protection Regulation: challenges and considerations for iPSC researchers and biobanks

PubMed Central

Morrison, Michael; Bell, Jessica; George, Carol; Harmon, Shawn; Munsie, Megan; Kaye, Jane

2017-01-01

Increasingly, human induced pluripotent stem cells (iPSC) and their associated genetic and clinical information are being used in a wide range of applications, with large biobanks being established to support and increase their scientific use. The new European General Data Protection Regulations, which comes into effect in 2018, will have implications for biobanks that generate, store and allow research access to iPSC. This paper describes some of the challenges that iPSC biobanks face and suggests some points for the development of appropriate governance structures to address these new requirements. These suggestions also have implications for iPSC research in general. PMID:28976812

View of Soviet ionospheric modification research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duncan, L.M.; Showen, R.L.

1990-10-01

We have reviewed and provided a technical assessment of Soviet research of the past five to ten years in ionospheric modification by high-power radio waves. This review includes a comprehensive survey of Soviet published literature, conference proceedings, and direct discussions with the involved Soviet researchers. The current state of the art for Soviet research in this field is evaluated, identifying areas of potential breakthrough discoveries, and discussing implications of this work for emerging technologies and future applications. This assessment is divided into the categories of basic research, advanced research, and applications. Basic research is further subdivided into studies of themore » modified natural geophysical environment, nonlinear plasma physics, and polar geophysical studies. Advanced research topics include the generation of artificial ionization mirrors and high-power oblique propagation effects. A separate comparative assessment of Soviet theoretical work also is included in this analysis. Our evaluation of practical and potential applications of this research discusses the utility of ionospheric modification in creating disturbed radio wave propagation environments, and its role in current and future remote-sensing and telecommunications systems. This technical assessment does not include consideration of ionospheric modification by means other than high-power radio waves. The Soviet effort in ionospheric modification sustains theoretical and experimental research at activity levels considerably greater than that found in comparable programs in the West. Notable strengths of the Soviet program are its breadth of coverage, large numbers of scientific participation, theoretical creativity and insight, and its powerful radio wave transmitting facilities.« less

Health research involving First Nations, Inuit and Métis children and their communities

PubMed Central

Starkes, Jill M; Baydala, Lola T

2014-01-01

Canadian and international guidelines address the ethical conduct of health research in general and the issues affecting Indigenous populations in particular. This statement summarizes, for clinicians and researchers, relevant ethical and practical considerations for health research involving Aboriginal children and youth. While not intended to duplicate findings arising from lengthy collaborative processes, it does highlight ‘wise practices’ that have successfully generated knowledge relevant to, respectful of and useful for Aboriginal children, youth and their communities. Further research on current health issues and inequities should lead to practical, effective and culturally relevant applications. Expanding our knowledge of ways to address the health disparities facing Canada’s Aboriginal children and youth can inform health policy and the provision of services. Community-based participatory research is proposed as a means to achieve this goal. PMID:24596485

MALDI Imaging Mass Spectrometry (MALDI-IMS)—Application of Spatial Proteomics for Ovarian Cancer Classification and Diagnosis

PubMed Central

Gustafsson, Johan O. R.; Oehler, Martin K.; Ruszkiewicz, Andrew; McColl, Shaun R.; Hoffmann, Peter

2011-01-01

MALDI imaging mass spectrometry (MALDI-IMS) allows acquisition of mass data for metabolites, lipids, peptides and proteins directly from tissue sections. IMS is typically performed either as a multiple spot profiling experiment to generate tissue specific mass profiles, or a high resolution imaging experiment where relative spatial abundance for potentially hundreds of analytes across virtually any tissue section can be measured. Crucially, imaging can be achieved without prior knowledge of tissue composition and without the use of antibodies. In effect MALDI-IMS allows generation of molecular data which complement and expand upon the information provided by histology including immuno-histochemistry, making its application valuable to both cancer biomarker research and diagnostics. The current state of MALDI-IMS, key biological applications to ovarian cancer research and practical considerations for analysis of peptides and proteins on ovarian tissue are presented in this review. PMID:21340013

MALDI Imaging Mass Spectrometry (MALDI-IMS)-application of spatial proteomics for ovarian cancer classification and diagnosis.

PubMed

Gustafsson, Johan O R; Oehler, Martin K; Ruszkiewicz, Andrew; McColl, Shaun R; Hoffmann, Peter

2011-01-21

MALDI imaging mass spectrometry (MALDI-IMS) allows acquisition of mass data for metabolites, lipids, peptides and proteins directly from tissue sections. IMS is typically performed either as a multiple spot profiling experiment to generate tissue specific mass profiles, or a high resolution imaging experiment where relative spatial abundance for potentially hundreds of analytes across virtually any tissue section can be measured. Crucially, imaging can be achieved without prior knowledge of tissue composition and without the use of antibodies. In effect MALDI-IMS allows generation of molecular data which complement and expand upon the information provided by histology including immuno-histochemistry, making its application valuable to both cancer biomarker research and diagnostics. The current state of MALDI-IMS, key biological applications to ovarian cancer research and practical considerations for analysis of peptides and proteins on ovarian tissue are presented in this review.

Advising on Preferred Reporting Items for patient-reported outcome instrument development: the PRIPROID.

PubMed

Hou, Zheng-Kun; Liu, Feng-Bin; Fang, Ji-Qian; Li, Xiao-Ying; Li, Li-Juan; Lin, Chu-Hua

2013-03-01

The reporting of patient-reported outcomes (PRO) instrument development is vital for both researchers and clinicians to determine its validity, thus, we propose the Preferred Reporting Items for PRO Instrument Development (PRIPROID) to improve the quality of reports. Abiding by the guidance published by the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) Network, we had performed 6 steps for items development: identified the need for a guideline, performed a literature review, obtained funding for the guideline initiative, identified participants, conducted a Delphi exercise and generated a list of PRIPROID items for consideration at the face-to-face meeting. Twenty three items subheadings under 7 topics were included: title and structured abstract, rationale, objectives, intention, eligibility criteria, conceptual framework, items generation, response options, scoring, times, administrative modes, burden assessment, properties assessment, statistical methods, participants, main results, and additional analysis, summary of evidence, limitations, clinical attentions, and conclusions, item pools or final form, and funding. The PRIPROID contains many elements of the PRO research, and this assists researchers to report their results more accurately and to a certain degree use this instrument to evaluate the quality of the research methods.

Generation Changes over the Period of 1986-2006 in the Physical Fitness of Boys Aged 7-19 from Eastern Poland at Particular Stages of Education

ERIC Educational Resources Information Center

Saczuk, Jerzy; Wasiluk, Agnieszka; Zalech, Miroslaw

2012-01-01

Study aim: To assess the size of secular trends in the physical fitness of boys from eastern Poland taking into consideration stages of education. Material and methods: The physical fitness results of boys aged 7-19 years living in eastern regions of Poland were analyzed: 3188 students were examined in 1986 while in 2006 the research included 10…

Theory of plasmonic effects in nonlinear optics: the case of graphene

NASA Astrophysics Data System (ADS)

Rostami, Habib; Katsnelson, Mikhail I.; Polini, Marco; Mikhail I. Katsnelson Collaboration; Habib Rostami; Marco Polini Collaboration

The nonlinear optical properties of two-dimensional electronic systems are beginning to attract considerable interest both in the theoretical and experimental sectors. Recent experiments on the nonlinear optical properties of graphene reveal considerably strong third harmonic generation and four-wave mixing of this single-atomic-layer electronic system. We develop a large-N theory of electron-electron interaction corrections to multi-legged Feynman diagrams describing second- and third-order nonlinear response functions. Our theory is completely general and is useful to understand all second- and third-order nonlinear effects, including harmonic generation, wave mixing, and photon drag. We apply our theoretical framework to the case of graphene, by carrying out microscopic calculations of the second- and third-order nonlinear response functions of an interacting two-dimensional gas of massless Dirac fermions. We compare our results with recent measurements, where all-optical launching of graphene plasmons has been achieved. This work was supported by Fondazione Istituto Italiano di Tecnologia, the European Union's Horizon 2020 research and innovation programme under Grant agreement No. 696656 GrapheneCore, and the ERC Advanced Grant 338957 FEMTO/NANO (M.I.K.).

Adequacy assessment of composite generation and transmission systems incorporating wind energy conversion systems

NASA Astrophysics Data System (ADS)

Gao, Yi

The development and utilization of wind energy for satisfying electrical demand has received considerable attention in recent years due to its tremendous environmental, social and economic benefits, together with public support and government incentives. Electric power generation from wind energy behaves quite differently from that of conventional sources. The fundamentally different operating characteristics of wind energy facilities therefore affect power system reliability in a different manner than those of conventional systems. The reliability impact of such a highly variable energy source is an important aspect that must be assessed when the wind power penetration is significant. The focus of the research described in this thesis is on the utilization of state sampling Monte Carlo simulation in wind integrated bulk electric system reliability analysis and the application of these concepts in system planning and decision making. Load forecast uncertainty is an important factor in long range planning and system development. This thesis describes two approximate approaches developed to reduce the number of steps in a load duration curve which includes load forecast uncertainty, and to provide reasonably accurate generating and bulk system reliability index predictions. The developed approaches are illustrated by application to two composite test systems. A method of generating correlated random numbers with uniform distributions and a specified correlation coefficient in the state sampling method is proposed and used to conduct adequacy assessment in generating systems and in bulk electric systems containing correlated wind farms in this thesis. The studies described show that it is possible to use the state sampling Monte Carlo simulation technique to quantitatively assess the reliability implications associated with adding wind power to a composite generation and transmission system including the effects of multiple correlated wind sites. This is an important development as it permits correlated wind farms to be incorporated in large practical system studies without requiring excessive increases in computer solution time. The procedures described in this thesis for creating monthly and seasonal wind farm models should prove useful in situations where time period models are required to incorporate scheduled maintenance of generation and transmission facilities. There is growing interest in combining deterministic considerations with probabilistic assessment in order to evaluate the quantitative system risk and conduct bulk power system planning. A relatively new approach that incorporates deterministic and probabilistic considerations in a single risk assessment framework has been designated as the joint deterministic-probabilistic approach. The research work described in this thesis illustrates that the joint deterministic-probabilistic approach can be effectively used to integrate wind power in bulk electric system planning. The studies described in this thesis show that the application of the joint deterministic-probabilistic method provides more stringent results for a system with wind power than the traditional deterministic N-1 method because the joint deterministic-probabilistic technique is driven by the deterministic N-1 criterion with an added probabilistic perspective which recognizes the power output characteristics of a wind turbine generator.

Field experiments on solar geoengineering: report of a workshop exploring a representative research portfolio.

PubMed

Keith, David W; Duren, Riley; MacMartin, Douglas G

2014-12-28

We summarize a portfolio of possible field experiments on solar radiation management (SRM) and related technologies. The portfolio is intended to support analysis of potential field research related to SRM including discussions about the overall merit and risk of such research as well as mechanisms for governing such research and assessments of observational needs. The proposals were generated with contributions from leading researchers at a workshop held in March 2014 at which the proposals were critically reviewed. The proposed research dealt with three major classes of SRM proposals: marine cloud brightening, stratospheric aerosols and cirrus cloud manipulation. The proposals are summarized here along with an analysis exploring variables such as space and time scale, risk and radiative forcing. Possible gaps, biases and cross-cutting considerations are discussed. Finally, suggestions for plausible next steps in the development of a systematic research programme are presented.

Field experiments on solar geoengineering: report of a workshop exploring a representative research portfolio

PubMed Central

Keith, David W.; Duren, Riley; MacMartin, Douglas G.

2014-01-01

We summarize a portfolio of possible field experiments on solar radiation management (SRM) and related technologies. The portfolio is intended to support analysis of potential field research related to SRM including discussions about the overall merit and risk of such research as well as mechanisms for governing such research and assessments of observational needs. The proposals were generated with contributions from leading researchers at a workshop held in March 2014 at which the proposals were critically reviewed. The proposed research dealt with three major classes of SRM proposals: marine cloud brightening, stratospheric aerosols and cirrus cloud manipulation. The proposals are summarized here along with an analysis exploring variables such as space and time scale, risk and radiative forcing. Possible gaps, biases and cross-cutting considerations are discussed. Finally, suggestions for plausible next steps in the development of a systematic research programme are presented. PMID:25404684

Numerical grid generation in computational field simulations. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Soni, B.K.; Thompson, J.F.; Haeuser, J.

1996-12-31

To enhance the CFS technology to its next level of applicability (i.e., to create acceptance of CFS in an integrated product and process development involving multidisciplinary optimization) the basic requirements are: rapid turn-around time, reliable and accurate simulation, affordability and appropriate linkage to other engineering disciplines. In response to this demand, there has been a considerable growth in the grid generation related research activities involving automization, parallel processing, linkage with the CAD-CAM systems, CFS with dynamic motion and moving boundaries, strategies and algorithms associated with multi-block structured, unstructured, hybrid, hexahedral, and Cartesian grids, along with its applicability to various disciplinesmore » including biomedical, semiconductor, geophysical, ocean modeling, and multidisciplinary optimization.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teherani, James T., E-mail: j.teherani@columbia.edu; Agarwal, Sapan; Chern, Winston

Many in the microelectronics field view tunneling field-effect transistors (TFETs) as society's best hope for achieving a >10× power reduction for electronic devices; however, despite a decade of considerable worldwide research, experimental TFET results have significantly underperformed simulations and conventional MOSFETs. To explain the discrepancy between TFET experiments and simulations, we investigate the parasitic leakage current due to Auger generation, an intrinsic mechanism that cannot be mitigated with improved material quality or better device processing. We expose the intrinsic link between the Auger and band-to-band tunneling rates, highlighting the difficulty of increasing one without the other. From this link, wemore » show that Auger generation imposes a fundamental limit on ultimate TFET performance.« less

Next-generation sequencing: hype and hope for development of personalized radiation therapy?

PubMed

Tinhofer, Ingeborg; Niehr, Franziska; Konschak, Robert; Liebs, Sandra; Munz, Matthias; Stenzinger, Albrecht; Weichert, Wilko; Keilholz, Ulrich; Budach, Volker

2015-08-28

The introduction of next-generation sequencing (NGS) in the field of cancer research has boosted worldwide efforts of genome-wide personalized oncology aiming at identifying predictive biomarkers and novel actionable targets. Despite considerable progress in understanding the molecular biology of distinct cancer entities by the use of this revolutionary technology and despite contemporaneous innovations in drug development, translation of NGS findings into improved concepts for cancer treatment remains a challenge. The aim of this article is to describe shortly the NGS platforms for DNA sequencing and in more detail key achievements and unresolved hurdles. A special focus will be given on potential clinical applications of this innovative technique in the field of radiation oncology.

High productivity machining of holes in Inconel 718 with SiAlON tools

NASA Astrophysics Data System (ADS)

Agirreurreta, Aitor Arruti; Pelegay, Jose Angel; Arrazola, Pedro Jose; Ørskov, Klaus Bonde

2016-10-01

Inconel 718 is often employed in aerospace engines and power generation turbines. Numerous researches have proven the enhanced productivity when turning with ceramic tools compared to carbide ones, however there is considerably less information with regard to milling. Moreover, no knowledge has been published about machining holes with this type of tools. Additional research on different machining techniques, like for instance circular ramping, is critical to expand the productivity improvements that ceramics can offer. In this a 3D model of the machining and a number of experiments with SiAlON round inserts have been carried out in order to evaluate the effect of the cutting speed and pitch on the tool wear and chip generation. The results of this analysis show that three different types of chips are generated and also that there are three potential wear zones. Top slice wear is identified as the most critical wear type followed by the notch wear as a secondary wear mechanism. Flank wear and adhesion are also found in most of the tests.

[A framework for evaluating ethical issues of public health initiatives: practical aspects and theoretical implications].

PubMed

Petrini, Carlo

2015-01-01

The "Framework for the Ethical Conduct of Public Health Initiatives", developed by Public Health Ontario, is a practical guide for assessing the ethical implications of evidence-generating public health initiatives, whether research or non-research activities, involving people, their biological materials or their personal information. The Framework is useful not only to those responsible for determining the ethical acceptability of an initiative, but also to investigators planning new public health initiatives. It is informed by a theoretical approach that draws on widely shared bioethical principles. Two considerations emerge from both the theoretical framework and its practical application: the line between practice and research is often blurred; public health ethics and biomedical research ethics are based on the same common heritage of values.

MO-E-BRC-00: Online Adaptive Radiotherapy - Considerations for Practical Clinical Implementation

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Online adaptive radiation therapy has the potential to ensure delivery of optimal treatment to the patient by accounting for anatomical and potentially functional changes that occur from one fraction to the next and over the course of treatment. While on-line adaptive RT (ART) has been a topic of many publications, discussions, and research, it has until very recently remained largely a concept and not a practical implementation. However, recent advances in on-table imaging, use of deformable image registration for contour generation and dose tracking, faster and more efficient plan optimization, as well as fast quality assurance method has enabled themore » implementation of ART in the clinic in the past couple of years. The introduction of these tools into routine clinical use requires many considerations and progressive knowledge to understand how processes that have historically taken hours/days to complete can now be done in less than 30 minutes. This session will discuss considerations to perform real time contouring, planning and patient specific QA, as well as a practical workflow and the required resources. Learning Objectives: To understand the difficulties, challenges and available technologies for online adaptive RT. To understand how to implement online adaptive therapy in a clinical environment and to understand the workflow and resources required. To understand the limitations and sources of uncertainty in the online adaptive process I have research funding from ViewRay Inc. and Philips Medical Systems.; R. Kashani, I have research funding from ViewRay Inc. and Philips Medical Systems.; X. Li, Research supported by Elekta Inc.« less

Analysing generator matrices G of similar state but varying minimum determinants

NASA Astrophysics Data System (ADS)

Harun, H.; Razali, M. F.; Rahman, N. A. Abdul

2016-10-01

Since Tarokh discovered Space-Time Trellis Code (STTC) in 1998, a considerable effort has been done to improve the performance of the original STTC. One way of achieving enhancement is by focusing on the generator matrix G, which represents the encoder structure for STTC. Until now, researchers have only concentrated on STTCs of different states in analyzing the performance of generator matrix G. No effort has been made on different generator matrices G of similar state. The reason being, it is difficult to produce a wide variety of generator matrices G with diverse minimum determinants. In this paper a number of generator matrices G with minimum determinant of four (4), eight (8) and sixteen (16) of the same state (i.e., 4-PSK) have been successfully produced. The performance of different generator matrices G in term of their bit error rate and signal-to-noise ratio for a Rayleigh fading environment are compared and evaluated. It is found from the MATLAB simulation that at low SNR (<8), the BER of generator matrices G with smaller minimum determinant is comparatively lower than those of higher minimum determinant. However, at high SNR (>14) there is no significant difference between the BER of these generator matrices G.

Mainstreaming Climate Change: Recent and Ongoing Efforts to Understand, Improve, and Expand Consideration of Climate Change in Federal Water Resources Planning

NASA Astrophysics Data System (ADS)

Ferguson, I. M.; McGuire, M.; Broman, D.; Gangopadhyay, S.

2017-12-01

The Bureau of Reclamation is a Federal agency tasked with developing and managing water supply and hydropower projects in the Western U.S. Climate and hydrologic variability and change significantly impact management actions and outcomes across Reclamation's programs and initiatives, including water resource planning and operations, infrastructure design and maintenance, hydropower generation, and ecosystem restoration, among others. Planning, design, and implementation of these programs therefore requires consideration of future climate and hydrologic conditions will impact program objectives. Over the past decade, Reclamation and other Federal agencies have adopted new guidelines, directives, and mandates that require consideration of climate change in water resources planning and decision making. Meanwhile, the scientific community has developed a large number of climate projections, along with an array of models, methods, and tools to facilitate consideration of climate projections in planning and decision making. However, water resources engineers, planners, and decision makers continue to face challenges regarding how best to use the available data and tools to support major decisions, including decisions regarding infrastructure investments and long-term operating criteria. This presentation will discuss recent and ongoing research towards understanding, improving, and expanding consideration of climate projections and related uncertainties in Federal water resources planning and decision making. These research efforts address a variety of challenges, including: How to choose between available climate projection datasets and related methods, models, and tools—many of which are considered experimental or research tools? How to select an appropriate decision framework when design or operating alternatives may differ between climate scenarios? How to effectively communicate results of a climate impacts analysis to decision makers? And, how to improve robustness and resilience of water resources systems in the face of significant uncertainty? Discussion will focus on the intersection between technical challenges and decision making paradigms and the need for improved scientist-decision maker engagement through the lens of this Federal water management agency.

New developments in social interdependence theory.

PubMed

Johnson, David W; Johnson, Roger T

2005-11-01

Social interdependence theory is a classic example of the interaction of theory, research, and practice. The premise of the theory is the way that goals are structured determines how individuals interact, which in turn creates outcomes. Since its formulation nearly 60 years ago, social interdependence theory has been modified, extended, and refined on the basis of the increasing knowledge about, and application of, the theory. Researchers have conducted over 750 research studies on the relative merits of cooperative, competitive, and individualistic efforts and the conditions under which each is appropriate. Social interdependence theory has been widely applied, especially in education and business. These applications have resulted in revisions of the theory and the generation of considerable new research. The authors critically analyze the new developments resulting from extensive research on, and wide-scale applications of, social interdependence theory.

On the Consideration of Adoption and Implementation of The Next Generation Science Standards in a Local-Control Context: Supporting the Epistemology of Science through Education Policy

NASA Astrophysics Data System (ADS)

Lazzaro, Christopher C.

On the Consideration of Adoption and Implementation of The Next Generation Science Standards in a Local-Control Context: Supporting the Epistemology of Science through Education Policy. Christopher C Lazzaro. The primary purpose of this research is to understand how and why members at each of the three levels of the education system within a local-control state made the decisions they did in supporting or hindering the adoption and implementation of the Next Generation Science Standards. This research concentrates on three levels of the education system in a local-control state; 1) the state level, 2) the district level, and 3) the school/teacher level, while investigating the following questions: 1. To what extent, and in what ways, do members in each of the three levels of the state education system advocate for adoption and implementation of the Next Generation Science Standards? 2. Are the members in each of the three levels motivated or compelled to consider adoption and implementation of the Next Generation Science Standards, why or why not? 3. To what extent, and in what ways, do the members in each of the three levels take into account science epistemology in their overall consideration of adoption/implementation of the NGSS? The data drew from a series of interviews from a prior study, "Challenges of Implementing the Next Generation Science Standards in Local-Control States in the U.S." (Sevian, Foster, & Scheff, 2012). After these data were coded and analyzed around the three research questions, this phenomenographic research study identified four key findings: Key Finding 1 - As the District Coordinators are uniquely situated within the state education system to be able to see both the on-the-ground practical implications and the high-level policy pressures of adopting and implementing the NGSS, they reflect the deepest level of awareness of how to best advocate for adoption and implementation of the NGSS. Key Finding 2 - Motivation to adopt and implement the NGSS is highly nuanced. The most significant factor influencing motivation to adopt or implement the NGSS at each level is related to assessment. The reasons assessment affects motivation is different at each level. Key Finding 3 - Each interviewee at each level demonstrated awareness that the NGSS are significantly different from prior standards in some way. While teachers and SSCs sometimes cited the science practices as the critical difference, they were not able to meaningfully elaborate on what "science practices" are. Conversely, the District Coordinators demonstrated a deeper level of awareness and were able to comment more specifically on the practices and how they would affect science education in their state. Key Finding 4 - Regardless of level, the better a participant reflected an awareness of epistemology, the more likely they were to advocate for adoption and implementation of the NGSS. Similarly, the better a participant reflected an awareness of epistemology, the more likely they were motivated to consider adoption and implementation of the NGSS. The implications of the findings in this current study can; inform the supplemental materials and dissemination of information by standards writers, help policy makers engage stakeholders appropriately at each level by illustrating how national reform efforts play out in local-control states, and aid school based employees by identifying how and where they can participate in state level policy discussion and where their input could be valuable.

Reflections on Women's Retirement.

PubMed

Karpen, Ruth Ray

2017-02-01

Popular literature often claims that baby boom women will "redefine" retirement, and there is some evidence in the gerontological literature that this may be true. However, considerably more research needs to be done on this generation of retirees. The author, a baby boomer herself, draws on recent research on retirement and her own experiences in early retirement to examine what a "good retirement" might mean, considering the diversity of baby boomers, the range of their experiences, and their relationship to work. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Securing Wireless Communications of the Internet of Things from the Physical Layer, An Overview

NASA Astrophysics Data System (ADS)

Zhang, Junqing; Duong, Trung; Woods, Roger; Marshall, Alan

2017-08-01

The security of the Internet of Things (IoT) is receiving considerable interest as the low power constraints and complexity features of many IoT devices are limiting the use of conventional cryptographic techniques. This article provides an overview of recent research efforts on alternative approaches for securing IoT wireless communications at the physical layer, specifically the key topics of key generation and physical layer encryption. These schemes can be implemented and are lightweight, and thus offer practical solutions for providing effective IoT wireless security. Future research to make IoT-based physical layer security more robust and pervasive is also covered.

Non-Linear Effects in Knowledge Production

NASA Astrophysics Data System (ADS)

Purica, Ionut

2007-04-01

The generation of technological knowledge is paramount to our present development; the production of technological knowledge is governed by the same Cobb Douglas type model, with the means of research and the intelligence level replacing capital, respectively labor. We are exploring the basic behavior of present days' economies that are producing technological knowledge, along with the `usual' industrial production and determine a basic behavior that turns out to be a `Henon attractor'. Measures are introduced for the gain of technological knowledge and for the information of technological sequences that are based respectively on the underlying multi-valued modal logic of the technological research and on nonlinear thermodynamic considerations.

76 FR 388 - Southern Nuclear Operating Company; Vogtle Electric Generating Plant, Unit Nos. 1 and 2; Notice...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-04

... Design,'' GDC 31, ``Fracture Prevention of Reactor Coolant Pressure Boundary,'' and GDC 32, ``Inspection... Operating Company; Vogtle Electric Generating Plant, Unit Nos. 1 and 2; Notice of Consideration of Issuance of Amendment to Facility Operating License, Proposed No Significant Hazards Consideration...

Caring for Patients of the Millennial Generation: Considerations for Nurses.

PubMed

Johanson, Linda S

2017-07-01

Much has been written about teaching students of the Millennial Generation (those born between the years 1980 and 2000) and about intergenerational dynamics in the healthcare workforce. However, little can be found in the literature regarding generation-specific nursing care of Millennial patients. This article presents six categories of considerations for nurses caring for patients of the Millennial Generation based on the characteristics, attitudes, and values that have influenced them as well as the healthcare issues confronting this group of young adults. © 2016 Wiley Periodicals, Inc.

Climate Change and Morality: Students' perspectives on the individual and society

NASA Astrophysics Data System (ADS)

Sternäng, Li; Lundholm, Cecilia

2011-05-01

There is a growing interest in addressing moral aspects in the research and education of socio-scientific issues. This paper investigates students' interpretations of climate change from a moral perspective. The students were 14 years old, studying at Green Schools in the Beijing area, China. The study was based on semi-structured group interviews and the data were analysed from an intentional perspective, which means that both cognitive and situational aspects were taken into consideration in the analysis. Previous research has revealed a close relation between morality and socio-scientific issues and also advocated the need for addressing ethical aspects in science education. However, empirical studies exploring the question of what students' moral reasoning might look like at the individual level have not yet generated enough attention. In this study this is the core focus of interest. The findings show that the students conceptualise the solutions to mitigating climate change in relation to two different stances. That is, they contextualise the problems and solutions by addressing the individual, where the individual is either 'myself' or 'someone else'. The different notions of the individual become crucial as the students' views and considerations for the environment, as well as society, change according to the different contexts. From a moral point of view, the students seem quite unaware of their varying consideration for others, the environment and society. The paper ends with a discussion of implications for practice and research.

High-level managers' considerations for RFID adoption in hospitals: an empirical study in Taiwan.

PubMed

Lai, Hui-Min; Lin, I-Chun; Tseng, Ling-Tzu

2014-02-01

Prior researches have indicated that an appropriate adoption of information technology (IT) can help hospitals significantly improve services and operations. Radio Frequency Identification (RFID) is believed to be the next generation innovation technology for automatic data collection and asset/people tracking. Based on the Technology-Organization-Environment (TOE) framework, this study investigated high-level managers' considerations for RFID adoption in hospitals. This research reviewed literature related IT adoption in business and followed the results of a preliminary survey with 37 practical experts in hospitals to theorize a model for the RFID adoption in hospitals. Through a field survey of 102 hospitals and hypotheses testing, this research identified key factors influencing RFID adoption. Follow-up in-depth interviews with three high-level managers of IS department from three case hospitals respectively also presented an insight into the decision of RFID's adoption. Based on the research findings, cost, ubiquity, compatibility, security and privacy risk, top management support, hospital scale, financial readiness and government policy were concluded to be the key factors influencing RFID adoption in hospitals. For practitioners, this study provided a comprehensive overview of government policies able to promote the technology, while helping the RFID solution providers understand how to reduce the IT barriers in order to enhance hospitals' willingness to adopt RFID.

Research data collection methods: from paper to tablet computers.

PubMed

Wilcox, Adam B; Gallagher, Kathleen D; Boden-Albala, Bernadette; Bakken, Suzanne R

2012-07-01

Primary data collection is a critical activity in clinical research. Even with significant advances in technical capabilities, clear benefits of use, and even user preferences for using electronic systems for collecting primary data, paper-based data collection is still common in clinical research settings. However, with recent developments in both clinical research and tablet computer technology, the comparative advantages and disadvantages of data collection methods should be determined. To describe case studies using multiple methods of data collection, including next-generation tablets, and consider their various advantages and disadvantages. We reviewed 5 modern case studies using primary data collection, using methods ranging from paper to next-generation tablet computers. We performed semistructured telephone interviews with each project, which considered factors relevant to data collection. We address specific issues with workflow, implementation and security for these different methods, and identify differences in implementation that led to different technology considerations for each case study. There remain multiple methods for primary data collection, each with its own strengths and weaknesses. Two recent methods are electronic health record templates and next-generation tablet computers. Electronic health record templates can link data directly to medical records, but are notably difficult to use. Current tablet computers are substantially different from previous technologies with regard to user familiarity and software cost. The use of cloud-based storage for tablet computers, however, creates a specific challenge for clinical research that must be considered but can be overcome.

[Neurotrophin therapy. Some bioethical considerations].

PubMed

Serrano-Sánchez, T; Díaz-Armesto, I

Bioethics , which provides a new ethical outlook on human life, is a term used in public health and biomedical research issues. It is for this reason that, in this paper, we decided to analyse certain aspects associated with the ethical considerations we must bear in mind when conducting research in humans, although the purpose of doing so is to cure or to improve the quality of life of people who suffer from certain diseases, many of which are fatal. Reasons are put forward to make it necessary to doubt which is the strategy with the most favourable benefit/risk relation for those who will undergo such interventions. We describe Alzheimer s disease and discuss the possible use of neurotrophic drugs in the treatment of this disorder (NGF therapy). We also emphasise the care that will have to be taken in each of the stages of development of the research. That is why we are witnessing the emergence of a new culture that is needed to regulate the multiple interventions that can be performed on life, and to guarantee the primacy of what is good, both for the human being of today and those of generations to come.

Drag reduction in nature

NASA Technical Reports Server (NTRS)

Bushnell, D. M.; Moore, K. J.

1991-01-01

Recent studies on the drag-reducing shapes, structures, and behaviors of swimming and flying animals are reviewed, with an emphasis on potential analogs in vehicle design. Consideration is given to form drag reduction (turbulent flow, vortex generation, mass transfer, and adaptations for body-intersection regions), skin-friction drag reduction (polymers, surfactants, and bubbles as surface 'additives'), reduction of the drag due to lift, drag-reduction studies on porpoises, and drag-reducing animal behavior (e.g., leaping out of the water by porpoises). The need for further research is stressed.

Challenges and considerations for the design and production of a purpose-optimized body-worn wrist-watch computer

NASA Astrophysics Data System (ADS)

Narayanaswami, Chandra; Raghunath, Mandayam T.

2004-09-01

We outline a collection of technological challenges in the design of wearable computers with a focus on one of the most desirable form-factors, the wrist watch. We describe our experience with building three generations of wrist watch computers. We built these research prototypes as platforms to investigate the fundamental limitations of wearable computing. Results of our investigations are presented in the form of challenges that have been overcome and those that still remain.

Small Business Innovations (Helicopters)

NASA Technical Reports Server (NTRS)

1992-01-01

The amount of engine power required for a helicopter to hover is an important, but difficult, consideration in helicopter design. The EHPIC program model produces converged, freely distorted wake geometries that generate accurate analysis of wake-induced downwash, allowing good predictions of rotor thrust and power requirements. Continuum Dynamics, Inc., the Small Business Innovation Research (SBIR) company that developed EHPIC, also produces RotorCRAFT, a program for analysis of aerodynamic loading of helicopter blades in forward flight. Both helicopter codes have been licensed to commercial manufacturers.

Database for propagation models

NASA Astrophysics Data System (ADS)

Kantak, Anil V.

1991-07-01

A propagation researcher or a systems engineer who intends to use the results of a propagation experiment is generally faced with various database tasks such as the selection of the computer software, the hardware, and the writing of the programs to pass the data through the models of interest. This task is repeated every time a new experiment is conducted or the same experiment is carried out at a different location generating different data. Thus the users of this data have to spend a considerable portion of their time learning how to implement the computer hardware and the software towards the desired end. This situation may be facilitated considerably if an easily accessible propagation database is created that has all the accepted (standardized) propagation phenomena models approved by the propagation research community. Also, the handling of data will become easier for the user. Such a database construction can only stimulate the growth of the propagation research it if is available to all the researchers, so that the results of the experiment conducted by one researcher can be examined independently by another, without different hardware and software being used. The database may be made flexible so that the researchers need not be confined only to the contents of the database. Another way in which the database may help the researchers is by the fact that they will not have to document the software and hardware tools used in their research since the propagation research community will know the database already. The following sections show a possible database construction, as well as properties of the database for the propagation research.

DRAGON Grid: A Three-Dimensional Hybrid Grid Generation Code Developed

NASA Technical Reports Server (NTRS)

Liou, Meng-Sing

2000-01-01

Because grid generation can consume 70 percent of the total analysis time for a typical three-dimensional viscous flow simulation for a practical engineering device, payoffs from research and development could reduce costs and increase throughputs considerably. In this study, researchers at the NASA Glenn Research Center at Lewis Field developed a new hybrid grid approach with the advantages of flexibility, high-quality grids suitable for an accurate resolution of viscous regions, and a low memory requirement. These advantages will, in turn, reduce analysis time and increase accuracy. They result from an innovative combination of structured and unstructured grids to represent the geometry and the computation domain. The present approach makes use of the respective strengths of both the structured and unstructured grid methods, while minimizing their weaknesses. First, the Chimera grid generates high-quality, mostly orthogonal meshes around individual components. This process is flexible and can be done easily. Normally, these individual grids are required overlap each other so that the solution on one grid can communicate with another. However, when this communication is carried out via a nonconservative interpolation procedure, a spurious solution can result. Current research is aimed at entirely eliminating this undesired interpolation by directly replacing arbitrary grid overlapping with a nonstructured grid called a DRAGON grid, which uses the same set of conservation laws over the entire region, thus ensuring conservation everywhere. The DRAGON grid is shown for a typical film-cooled turbine vane with 33 holes and 3 plenum compartments. There are structured grids around each geometrical entity and unstructured grids connecting them. In fiscal year 1999, Glenn researchers developed and tested the three-dimensional DRAGON grid-generation tools. A flow solver suitable for the DRAGON grid has been developed, and a series of validation tests are underway.

Centers for Disease Control and Prevention injury research agenda: identification of acute care research topics of interest to the Centers for disease Control and Prevention--National Center for Injury Prevention and Control.

PubMed

Jurkovich, Gregory J; Rivara, Frederick P; Johansen, Jennifer M; Maier, Ronald V

2004-05-01

The purpose of this report is to identify the most important research questions pertaining to the acute care of the injured patient using a Web-based Delphi technique to achieve expert opinion consensus. Experts in trauma care from the United States and Canada (n =39) generated structured research questions and then ranked these questions in order of importance, using a Web-based survey for question generation, question ranking, and a Delphi technique of consensus. Guidelines for question construction and ranking specified that participants considered questions that fall within the interest and domain of the Centers for Disease Control (CDC)-National Center for Injury Prevention and Control (NCIPC). One hundred thirty-seven questions in 18 distinct categories of interest were initially generated. After two rounds of merging, collating, reassessing, and ranking by significance and importance, 25 research questions were deemed most important and significant in the care of the injured patient. Ten of these (40%) were considered to be appropriate issues for the CDC-NCIPC to address and fund, dealing with injury prevention strategies, trauma systems design and funding, the epidemiology of injury, and global outcome determinants. These 25 questions were also reviewed with consideration given to the most likely source of federal funding of investigations. This report identifies the areas of trauma care in which research efforts might best be directed. Fully 40% of the key research questions could be considered to fall under the interest and auspices of the CDC-NCIPC. The remaining questions cover a broad range of topics and likely funding sources, emphasizing the need for a coordinated oversight of research funding in trauma care.

Forgotten but not gone: an examination of fit between leader consideration and initiating structure needed and received.

PubMed

Lambert, Lisa Schurer; Tepper, Bennett J; Carr, Jon C; Holt, Daniel T; Barelka, Alex J

2012-09-01

We examined the effects of fit between leader consideration and initiating structure needed and received on employees' work-related attitudes (i.e., trust in the supervisor, job satisfaction, and affective commitment to the organization). Consistent with predictions that derive from the person-environment fit research tradition, results from Study 1 suggested that deficient amounts of both leadership behaviors were associated with unfavorable attitudinal outcomes. However, while excess levels of consideration were associated with favorable attitudinal outcomes, excess levels of initiating structure were associated with unfavorable attitudes, and for both forms of leadership, higher levels of absolute fit were associated with more favorable outcomes. Results from Study 2 suggested that attitudes generated by the fit between leadership needed and received influence employees' organizational citizenship behavior as reported by their supervisors. The relationship between consideration needed and received and subordinates' organizational citizenship behavior relating to individuals (OCBI) and organizational citizenship behavior relating to the organization itself (OCBO) was partially mediated by employees' trust in the supervisor, while the relationship between initiating structure needed and received and OCBI was fully mediated by trust in the supervisor, and for OCBO was partially mediated.

An update of engine system research at the Army Propulsion Directorate

NASA Technical Reports Server (NTRS)

Bobula, George A.

1990-01-01

The Small Turboshaft Engine Research (STER) program provides a vehicle for evaluating the application of emerging technologies to Army turboshaft engine systems and to investigate related phenomena. Capitalizing on the resources at hand, in the form of both the NASA facilities and the Army personnel, the program goal of developing a physical understanding of engine system dynamics and/or system interactions is being realized. STER entries investigate concepts and components developed both in-house and out-of-house. Emphasis is placed upon evaluations which evolved from on-going basic research and advanced development programs. Army aviation program managers are also encouraged to make use of STER resources, both people and facilities. The STER personnel have established their reputations as experts in the fields of engine system experimental evaluations and engine system related phenomena. The STER facility has STER program provides the Army aviation community the opportunity to perform system level investigations, and then to offer the findings to the entire engine community for their consideration in next generation propulsion systems. In this way results of the fundamental research being conducted to meet small turboshaft engine technology challenges expeditiously find their way into that next generation of propulsion systems.

Sex, gender, and health biotechnology: points to consider

PubMed Central

2009-01-01

Background Reproductive technologies have been extensively debated in the literature. As well, feminist economists, environmentalists, and agriculturalists have generated substantial debate and literature on gender. However, the implications for women of health biotechnologies have received relatively less attention. Surprisingly, while gender based frameworks have been proposed in the context of public health policy, practice, health research, and epidemiological research, we could identify no systematic framework for gender analysis of health biotechnology in the developing world. Discussion We propose sex and gender considerations at five critical stages of health biotechnology research and development: priority setting; technology design; clinical trials; commercialization, and health services delivery. Summary Applying a systematic sex and gender framework to five key process stages of health biotechnology research and development could be a first step towards unlocking the opportunities of this promising science for women in the developing world. PMID:19622163

Statistical Approach To Estimate Vaccinia-Specific Neutralizing Antibody Titers Using a High-Throughput Assay▿

PubMed Central

Kennedy, Richard; Pankratz, V. Shane; Swanson, Eric; Watson, David; Golding, Hana; Poland, Gregory A.

2009-01-01

Because of the bioterrorism threat posed by agents such as variola virus, considerable time, resources, and effort have been devoted to biodefense preparation. One avenue of this research has been the development of rapid, sensitive, high-throughput assays to validate immune responses to poxviruses. Here we describe the adaptation of a β-galactosidase reporter-based vaccinia virus neutralization assay to large-scale use in a study that included over 1,000 subjects. We also describe the statistical methods involved in analyzing the large quantity of data generated. The assay and its associated methods should prove useful tools in monitoring immune responses to next-generation smallpox vaccines, studying poxvirus immunity, and evaluating therapeutic agents such as vaccinia virus immune globulin. PMID:19535540

Energy scavenging using piezoelectric sensors to power in pavement intelligent vehicle detection systems

NASA Astrophysics Data System (ADS)

Parhad, Ashutosh

Intelligent transportation systems use in-pavement inductive loop sensors to collect real time traffic data. This method is very expensive in terms of installation and maintenance. Our research is focused on developing advanced algorithms capable of generating high amounts of energy that can charge a battery. This electromechanical energy conversion is an optimal way of energy scavenging that makes use of piezoelectric sensors. The power generated is sufficient to run the vehicle detection module that has several sensors embedded together. To achieve these goals, we have developed a simulation module using software's like LabVIEW and Multisim. The simulation module recreates a practical scenario that takes into consideration vehicle weight, speed, wheel width and frequency of the traffic.

The case for integrating grounded theory and participatory action research: empowering clients to inform professional practice.

PubMed

Teram, Eli; Schachter, Candice L; Stalker, Carol A

2005-10-01

Grounded theory and participatory action research methods are distinct approaches to qualitative inquiry. Although grounded theory has been conceptualized in constructivist terms, it has elements of positivist thinking with an image of neutral search for objective truth through rigorous data collection and analysis. Participatory action research is based on a critique of this image and calls for more inclusive research processes. It questions the possibility of objective social sciences and aspires to engage people actively in all stages of generating knowledge. The authors applied both approaches in a project designed to explore the experiences of female survivors of childhood sexual abuse with physical therapy and subsequently develop a handbook on sensitive practice for clinicians that takes into consideration the needs and perspectives of these clients. Building on this experience, they argue that the integration of grounded theory and participatory action research can empower clients to inform professional practice.

Recruitment of Yoruba families from Nigeria for genetic research: experience from a multisite keloid study.

PubMed

Olaitan, Peter B; Odesina, Victoria; Ademola, Samuel; Fadiora, Solomon O; Oluwatosin, Odunayo M; Reichenberger, Ernst J

2014-09-02

More involvement of sub-Saharan African countries in biomedical studies, specifically in genetic research, is needed to advance individualized medicine that will benefit non-European populations. Missing infrastructure, cultural and religious beliefs as well as lack of understanding of research benefits can pose a challenge to recruitment. Here we describe recruitment efforts for a large genetic study requiring three-generation pedigrees within the Yoruba homelands of Nigeria. The aim of the study was to identify genes responsible for keloids, a wound healing disorder. We also discuss ethical and logistical considerations that we encountered in preparation for this research endeavor. Protocols for this bi-national intercultural study were approved by the Institutional Review Board (IRB) in the US and the ethics committees of the Nigerian institutions for consideration of cultural differences. Principles of community based participatory research were employed throughout the recruitment process. Keloid patients (patient advisors), community leaders, kings/chiefs and medical directors were engaged to assist the research teams with recruitment strategies. Community meetings, church forums, and media outlets (study flyers, radio and TV announcements) were utilized to promote the study in Nigeria. Recruitment of research participants was conducted by trained staff from the local communities. Pedigree structures were re-analyzed on a regular basis as new family members were recruited and recruitment challenges were documented. Total recruitment surpassed 4200 study participants over a 7-year period including 79 families with complete three-generation pedigrees. In 9 families more than 20 family members participated, however, in 5 of these families, we encountered issues with pedigree structure as members from different branches presented inconsistent family histories. These issues were due to the traditional open family structure amongst the Yoruba and by beliefs in voodoo or in juju. In addition, family members living in other parts of the country or abroad complicated timely and complete family recruitment. Organizational, logistics and ethics challenges can be overcome by additional administrative efforts, good communication, community involvement and education of staff members. However, recruitment challenges due to infrastructural shortcomings or cultural and religious beliefs can lead to significant delays, which may negatively affect study time lines and expectations of funding agencies.

Simulated Patient Studies: An Ethical Analysis

PubMed Central

Rhodes, Karin V; Miller, Franklin G

2012-01-01

Context In connection with health care reform, the U.S. Department of Health and Human Services commissioned a “mystery shopper,” or simulated patient study, to measure access to primary care. But the study was shelved because of public controversy over “government spying” on doctors. Opponents of the study also raised ethical concerns about the use of deception with human subjects without soliciting their informed consent. Methods We undertook an ethical analysis of the use of simulated patient techniques in health services research, with a particular focus on research measuring access to care. Using a case study, we explored relevant methodological considerations and ethical principles relating to deceptive research without informed consent, as well as U.S. federal regulations permitting exceptions to consent. Findings Several relevant considerations both favor and oppose soliciting consent for simulated patient studies. Making research participation conditional on informed consent protects the autonomy of research subjects and shields them from unreasonable exposure to research risks. However, scientific validity is also an important ethical principle of human subjects research, as the net risks to subjects must be justified by the value to society of the knowledge to be gained. The use of simulated patients to monitor access is a naturalistic and scientifically sound experimental design that can answer important policy-relevant questions, with minimal risks to human subjects. As interaction between researchers and subjects increases, however, so does the need for consent. Conclusions As long as adequate protections of confidentiality of research data are in place, minimally intrusive simulated patient research that gathers policy-relevant data on the health system without the consent of individuals working in that system can be ethically justified when the risks and burdens to research subjects are minimal and the research has the potential to generate socially valuable knowledge. PMID:23216428

Progress In Optical Memory Technology

NASA Astrophysics Data System (ADS)

Tsunoda, Yoshito

1987-01-01

More than 20 years have passed since the concept of optical memory was first proposed in 1966. Since then considerable progress has been made in this area together with the creation of completely new markets of optical memory in consumer and computer application areas. The first generation of optical memory was mainly developed with holographic recording technology in late 1960s and early 1970s. Considerable number of developments have been done in both analog and digital memory applications. Unfortunately, these technologies did not meet a chance to be a commercial product. The second generation of optical memory started at the beginning of 1970s with bit by bit recording technology. Read-only type optical memories such as video disks and compact audio disks have extensively investigated. Since laser diodes were first applied to optical video disk read out in 1976, there have been extensive developments of laser diode pick-ups for optical disk memory systems. The third generation of optical memory started in 1978 with bit by bit read/write technology using laser diodes. Developments of recording materials including both write-once and erasable have been actively pursued at several research institutes. These technologies are mainly focused on the optical memory systems for computer application. Such practical applications of optical memory technology has resulted in the creation of such new products as compact audio disks and computer file memories.

An overview on ethical considerations in stem cell research in Iran and ethical recommendations: A review.

PubMed

Farajkhoda, Tahmineh

2017-02-01

Conducting research on the stem cell lines might bring some worthy good to public. Human Stem Cells (hSCs) research has provided opportunities for scientific progresses and new therapies, but some complex ethical matters should be noticed to ensure that stem cell research is carried out in an ethically appropriate manner. The aim of this review article is to discuss the importance of stem cell research, code of ethics for stem cell research in Iran and ethical recommendation. Generation of stem cells for research from human embryo or adult stem cells, saving, maintenance and using of them are the main ethical, legal and jurisprudence concerns in Iran. Concerns regarding human reproduction or human cloning, breach of human dignity, genetic manipulation and probability of tumorogenisity are observed in adult/somatic stem cells. Destruction of embryo to generate stem cell is an important matter in Iran. In this regards, obtaining stem cell from donated frozen embryos through infertility treatment that would be discarded is an acceptable solution in Iran for generation of embryo for research. Ethical, legal, and jurisprudence strategies for using adult/somatic stem cells are determination of ownership of stem cells, trade prohibition of human body, supervision on bio banks and information of Oversight Committee on Stem Cell Research. Recommendations to handle ethical issues for conducting stem cell research are well-designed studies, compliance codes of ethics in biomedical research (specifically codes of ethics on stem cell research, codes of ethics on clinical trials studies and codes of ethics on animals studies), appropriate collaboration with ethics committees and respecting of rights of participants (including both of human and animal rights) in research. In addition, there is a necessity for extending global networks of bioethics for strengthening communications within organizations at both the regional and international level, strengthening legislation systems, designing and establishing convenient collaborative educational courses at different levels.

An overview on ethical considerations in stem cell research in Iran and ethical recommendations: A review

PubMed Central

Farajkhoda, Tahmineh

2017-01-01

Conducting research on the stem cell lines might bring some worthy good to public. Human Stem Cells (hSCs) research has provided opportunities for scientific progresses and new therapies, but some complex ethical matters should be noticed to ensure that stem cell research is carried out in an ethically appropriate manner. The aim of this review article is to discuss the importance of stem cell research, code of ethics for stem cell research in Iran and ethical recommendation. Generation of stem cells for research from human embryo or adult stem cells, saving, maintenance and using of them are the main ethical, legal and jurisprudence concerns in Iran. Concerns regarding human reproduction or human cloning, breach of human dignity, genetic manipulation and probability of tumorogenisity are observed in adult/somatic stem cells. Destruction of embryo to generate stem cell is an important matter in Iran. In this regards, obtaining stem cell from donated frozen embryos through infertility treatment that would be discarded is an acceptable solution in Iran for generation of embryo for research. Ethical, legal, and jurisprudence strategies for using adult/somatic stem cells are determination of ownership of stem cells, trade prohibition of human body, supervision on bio banks and information of Oversight Committee on Stem Cell Research. Recommendations to handle ethical issues for conducting stem cell research are well-designed studies, compliance codes of ethics in biomedical research (specifically codes of ethics on stem cell research, codes of ethics on clinical trials studies and codes of ethics on animals studies), appropriate collaboration with ethics committees and respecting of rights of participants (including both of human and animal rights) in research. In addition, there is a necessity for extending global networks of bioethics for strengthening communications within organizations at both the regional and international level, strengthening legislation systems, designing and establishing convenient collaborative educational courses at different levels. PMID:28462397

An update of engine system research at the Army Propulsion Directorate

NASA Technical Reports Server (NTRS)

Bobula, George A.

1990-01-01

The Small Turboshaft Engine Research (STER) program provides a vehicle for evaluating the application of emerging technologies to Army turboshaft engine systems and to investigate related phenomena. Capitalizing on the resources at hand, in the form of both the NASA facilities and the Army personnel, the program goal of developing a physical understanding of engine system dynamics and/or system interactions is being realized. STER entries investigate concepts and components developed both in-house and out-of-house. Emphasis is placed upon evaluations which have evolved from on-going basic research and advanced development programs. Army aviation program managers are also encouraged to make use of STER resources, both people and facilities. The STER personnel have established their reputations as experts in the fields of engine system experimental evaluations and engine system related phenomena. The STER facility has demonstrated its utility in both research and development programs. The STER program provides the Army aviation community the opportunity to perform system level investigations, and then to offer the findings to the entire engine community for their consideration in next generation propulsion systems. In this way results of the fundamental research being conducted to meet small turboshaft engine technology challenges expeditiously find their way into that next generation of propulsion systems.

Ethics and Policy Issues for Stem Cell Research and Pulmonary Medicine

PubMed Central

Lowenthal, Justin

2015-01-01

Stem cell research and related initiatives in regenerative medicine, cell-based therapy, and tissue engineering have generated considerable scientific and public interest. Researchers are applying stem cell technologies to chest medicine in a variety of ways: using stem cells as models for drug discovery, testing stem cell-based therapies for conditions as diverse as COPD and cystic fibrosis, and producing functional lung and tracheal tissue for physiologic modeling and potential transplantation. Although significant scientific obstacles remain, it is likely that stem cell-based regenerative medicine will have a significant clinical impact in chest medicine. However, stem cell research has also generated substantial controversy, posing a variety of ethical and regulatory challenges for research and clinical practice. Some of the most prominent ethical questions related to the use of stem cell technologies in chest medicine include (1) implications for donors, (2) scientific prerequisites for clinical testing and use, (3) stem cell tourism, (4) innovation and clinical use of emerging stem cell-based interventions, (5) responsible translation of stem cell-based therapies to clinical use, and (6) appropriate and equitable access to emerging therapies. Having a sense of these issues should help to put emerging scientific advances into appropriate context and to ensure the responsible clinical translation of promising therapeutics. PMID:25732448

Ethics and policy issues for stem cell research and pulmonary medicine.

PubMed

Lowenthal, Justin; Sugarman, Jeremy

2015-03-01

Stem cell research and related initiatives in regenerative medicine, cell-based therapy, and tissue engineering have generated considerable scientific and public interest. Researchers are applying stem cell technologies to chest medicine in a variety of ways: using stem cells as models for drug discovery, testing stem cell-based therapies for conditions as diverse as COPD and cystic fibrosis, and producing functional lung and tracheal tissue for physiologic modeling and potential transplantation. Although significant scientific obstacles remain, it is likely that stem cell-based regenerative medicine will have a significant clinical impact in chest medicine. However, stem cell research has also generated substantial controversy, posing a variety of ethical and regulatory challenges for research and clinical practice. Some of the most prominent ethical questions related to the use of stem cell technologies in chest medicine include (1) implications for donors, (2) scientific prerequisites for clinical testing and use, (3) stem cell tourism, (4) innovation and clinical use of emerging stem cell-based interventions, (5) responsible translation of stem cell-based therapies to clinical use, and (6) appropriate and equitable access to emerging therapies. Having a sense of these issues should help to put emerging scientific advances into appropriate context and to ensure the responsible clinical translation of promising therapeutics.

Architecture of Explanatory Inference in the Human Prefrontal Cortex

PubMed Central

Barbey, Aron K.; Patterson, Richard

2011-01-01

Causal reasoning is a ubiquitous feature of human cognition. We continuously seek to understand, at least implicitly and often explicitly, the causal scenarios in which we live, so that we may anticipate what will come next, plan a potential response and envision its outcome, decide among possible courses of action in light of their probable outcomes, make midstream adjustments in our goal-related activities as our situation changes, and so on. A considerable body of research shows that the lateral prefrontal cortex (PFC) is crucial for causal reasoning, but also that there are significant differences in the manner in which ventrolateral PFC, dorsolateral PFC, and anterolateral PFC support causal reasoning. We propose, on the basis of research on the evolution, architecture, and functional organization of the lateral PFC, a general framework for understanding its roles in the many and varied sorts of causal reasoning carried out by human beings. Specifically, the ventrolateral PFC supports the generation of basic causal explanations and inferences; dorsolateral PFC supports the evaluation of these scenarios in light of some given normative standard (e.g., of plausibility or correctness in light of real or imagined causal interventions); and anterolateral PFC supports explanation and inference at an even higher level of complexity, coordinating the processes of generation and evaluation with further cognitive processes, and especially with computations of hedonic value and emotional implications of possible behavioral scenarios – considerations that are often critical both for understanding situations causally and for deciding about our own courses of action. PMID:21845182

Utilizing Big Data and Twitter to Discover Emergent Online Communities of Cannabis Users

PubMed Central

Baumgartner, Peter; Peiper, Nicholas

2017-01-01

Large shifts in medical, recreational, and illicit cannabis consumption in the United States have implications for personalizing treatment and prevention programs to a wide variety of populations. As such, considerable research has investigated clinical presentations of cannabis users in clinical and population-based samples. Studies leveraging big data, social media, and social network analysis have emerged as a promising mechanism to generate timely insights that can inform treatment and prevention research. This study extends a novel method called stochastic block modeling to derive communities of cannabis consumers as part of a complex social network on Twitter. A set of examples illustrate how this method can ascertain candidate samples of medical, recreational, and illicit cannabis users. Implications for research planning, intervention design, and public health surveillance are discussed. PMID:28615950

What is knowledge and when should it be implemented?

PubMed

O'Grady, Laura

2012-10-01

A primary purpose of research is to generate new knowledge. Scientific advances have progressively identified optimal ways to achieve this purpose. Included in this evolution are the notions of evidence-based medicine, decision aids, shared decision making, measurement and evaluation as well as implementation. The importance of including qualitative and quantitative methods in our research is now understood. We have debated the meaning of evidence and how to implement it. However, we have yet to consider how to include in our study findings other types of information such as tacit and experiential knowledge. This key consideration needs to take place before we translate new findings or 'knowledge' into clinical practice. This article critiques assumptions regarding the nature of knowledge and suggests a framework for implementing research findings into practice. © 2012 Blackwell Publishing Ltd.

Diagnosing and dealing with multicollinearity.

PubMed

Schroeder, M A

1990-04-01

The purpose of this article was to increase nurse researchers' awareness of the effects of collinear data in developing theoretical models for nursing practice. Collinear data distort the true value of the estimates generated from ordinary least-squares analysis. Theoretical models developed to provide the underpinnings of nursing practice need not be abandoned, however, because they fail to produce consistent estimates over repeated applications. It is also important to realize that multicollinearity is a data problem, not a problem associated with misspecification of a theorectical model. An investigator must first be aware of the problem, and then it is possible to develop an educated solution based on the degree of multicollinearity, theoretical considerations, and sources of error associated with alternative, biased, least-square regression techniques. Decisions based on theoretical and statistical considerations will further the development of theory-based nursing practice.

Crystallization mosaic effect generation by superpixels

NASA Astrophysics Data System (ADS)

Xie, Yuqi; Bo, Pengbo; Yuan, Ye; Wang, Kuanquan

2015-03-01

Art effect generation from digital images using computational tools has been a hot research topic in recent years. We propose a new method for generating crystallization mosaic effects from color images. Two key problems in generating pleasant mosaic effect are studied: grouping pixels into mosaic tiles and arrangement of mosaic tiles adapting to image features. To give visually pleasant mosaic effect, we propose to create mosaic tiles by pixel clustering in feature space of color information, taking compactness of tiles into consideration as well. Moreover, we propose a method for processing feature boundaries in images which gives guidance for arranging mosaic tiles near image features. This method gives nearly uniform shape of mosaic tiles, adapting to feature lines in an esthetic way. The new approach considers both color distance and Euclidean distance of pixels, and thus is capable of giving mosaic tiles in a more pleasing manner. Some experiments are included to demonstrate the computational efficiency of the present method and its capability of generating visually pleasant mosaic tiles. Comparisons with existing approaches are also included to show the superiority of the new method.

Modeling of unit operating considerations in generating-capacity reliability evaluation. Volume 1. Mathematical models, computing methods, and results. Final report. [GENESIS, OPCON and OPPLAN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patton, A.D.; Ayoub, A.K.; Singh, C.

1982-07-01

Existing methods for generating capacity reliability evaluation do not explicitly recognize a number of operating considerations which may have important effects in system reliability performance. Thus, current methods may yield estimates of system reliability which differ appreciably from actual observed reliability. Further, current methods offer no means of accurately studying or evaluating alternatives which may differ in one or more operating considerations. Operating considerations which are considered to be important in generating capacity reliability evaluation include: unit duty cycles as influenced by load cycle shape, reliability performance of other units, unit commitment policy, and operating reserve policy; unit start-up failuresmore » distinct from unit running failures; unit start-up times; and unit outage postponability and the management of postponable outages. A detailed Monte Carlo simulation computer model called GENESIS and two analytical models called OPCON and OPPLAN have been developed which are capable of incorporating the effects of many operating considerations including those noted above. These computer models have been used to study a variety of actual and synthetic systems and are available from EPRI. The new models are shown to produce system reliability indices which differ appreciably from index values computed using traditional models which do not recognize operating considerations.« less

An Opening Chapter of the First Generation of Artificial Intelligence in Medicine: The First Rutgers AIM Workshop, June 1975

PubMed Central

2015-01-01

Summary The first generation of Artificial Intelligence (AI) in Medicine methods were developed in the early 1970’s drawing on insights about problem solving in AI. They developed new ways of representing structured expert knowledge about clinical and biomedical problems using causal, taxonomic, associational, rule, and frame-based models. By 1975, several prototype systems had been developed and clinically tested, and the Rutgers Research Resource on Computers in Biomedicine hosted the first in a series of workshops on AI in Medicine that helped researchers and clinicians share their ideas, demonstrate their models, and comment on the prospects for the field. These developments and the workshops themselves benefited considerably from Stanford’s SUMEX-AIM pioneering experiment in biomedical computer networking. This paper focuses on discussions about issues at the intersection of medicine and artificial intelligence that took place during the presentations and panels at the First Rutgers AIM Workshop in New Brunswick, New Jersey from June 14 to 17, 1975. PMID:26123911

Delivering Sound Energy along an Arbitrary Convex Trajectory

PubMed Central

Zhao, Sipei; Hu, Yuxiang; Lu, Jing; Qiu, Xiaojun; Cheng, Jianchun; Burnett, Ian

2014-01-01

Accelerating beams have attracted considerable research interest due to their peculiar properties and various applications. Although there have been numerous research on the generation and application of accelerating light beams, few results have been published on the generation of accelerating acoustic beams. Here we report on the experimental observation of accelerating acoustic beams along arbitrary convex trajectories. The desired trajectory is projected to the spatial phase profile on the boundary which is discretized and sampled spatially. The sound field distribution is formulated with the Green function and the integral equation method. Both the paraxial and the non-paraxial regimes are examined and observed in the experiments. The effect of obstacle scattering in the sound field is also investigated and the results demonstrate that the approach is robust against obstacle scattering. The realization of accelerating acoustic beams will have an impact on various applications where acoustic information and energy are required to be delivered along an arbitrary convex trajectory. PMID:25316353

NASA Glenn Research Center Program in High Power Density Motors for Aeropropulsion

NASA Technical Reports Server (NTRS)

Brown, Gerald V.; Kascak, Albert F.; Ebihara, Ben; Johnson, Dexter; Choi, Benjamin; Siebert, Mark; Buccieri, Carl

2005-01-01

Electric drive of transport-sized aircraft propulsors, with electric power generated by fuel cells or turbo-generators, will require electric motors with much higher power density than conventional room-temperature machines. Cryogenic cooling of the motor windings by the liquid hydrogen fuel offers a possible solution, enabling motors with higher power density than turbine engines. Some context on weights of various systems, which is required to assess the problem, is presented. This context includes a survey of turbine engine weights over a considerable size range, a correlation of gear box weights and some examples of conventional and advanced electric motor weights. The NASA Glenn Research Center program for high power density motors is outlined and some technical results to date are presented. These results include current densities of 5,000 A per square centimeter current density achieved in cryogenic coils, finite element predictions compared to measurements of torque production in a switched reluctance motor, and initial tests of a cryogenic switched reluctance motor.

An Opening Chapter of the First Generation of Artificial Intelligence in Medicine: The First Rutgers AIM Workshop, June 1975.

PubMed

Kulikowski, C A

2015-08-13

The first generation of Artificial Intelligence (AI) in Medicine methods were developed in the early 1970's drawing on insights about problem solving in AI. They developed new ways of representing structured expert knowledge about clinical and biomedical problems using causal, taxonomic, associational, rule, and frame-based models. By 1975, several prototype systems had been developed and clinically tested, and the Rutgers Research Resource on Computers in Biomedicine hosted the first in a series of workshops on AI in Medicine that helped researchers and clinicians share their ideas, demonstrate their models, and comment on the prospects for the field. These developments and the workshops themselves benefited considerably from Stanford's SUMEX-AIM pioneering experiment in biomedical computer networking. This paper focuses on discussions about issues at the intersection of medicine and artificial intelligence that took place during the presentations and panels at the First Rutgers AIM Workshop in New Brunswick, New Jersey from June 14 to 17, 1975.

Evaluation of the efficiency and fault density of software generated by code generators

NASA Technical Reports Server (NTRS)

Schreur, Barbara

1993-01-01

Flight computers and flight software are used for GN&C (guidance, navigation, and control), engine controllers, and avionics during missions. The software development requires the generation of a considerable amount of code. The engineers who generate the code make mistakes and the generation of a large body of code with high reliability requires considerable time. Computer-aided software engineering (CASE) tools are available which generates code automatically with inputs through graphical interfaces. These tools are referred to as code generators. In theory, code generators could write highly reliable code quickly and inexpensively. The various code generators offer different levels of reliability checking. Some check only the finished product while some allow checking of individual modules and combined sets of modules as well. Considering NASA's requirement for reliability, an in house manually generated code is needed. Furthermore, automatically generated code is reputed to be as efficient as the best manually generated code when executed. In house verification is warranted.

Comparison of metallurgical coke and lignite coke for power generation in Thailand

NASA Astrophysics Data System (ADS)

Ratanakuakangwan, Sudlop; Tangjitsitcharoen, Somkiat

2017-04-01

This paper presents and compares two alternatives of cokes in power generation which are the metallurgical coke with coke oven gas and the coke from lignite under the consideration of the energy and the environment. These alternatives not only consume less fuel due to their higher heat content than conventional coal but also has less SO2 emission. The metallurgical coke and its by-product which is coke oven gas can be obtained from the carbonization process of coking coal. According to high grade coking coal, the result in the energy attitude is not profitable but its sulfur content that directly affects the emission of SO2 is considered to be very low. On the other hand, the coke produced from lignite is known as it is the lowest grade from coal and it causes the high pollution. Regarding to energy profitability, the lignite coke is considered to be much more beneficial than the metallurgical coke in contrast to the environmental concerns. However, the metallurgical coke has the highest heating value. Therefore, a decision making between those choices must be referred to the surrounding circumstances based on energy and environment as well as economic consideration in the further research.

Demystifying the Millennial student: a reassessment in measures of character and engagement in professional education.

PubMed

DiLullo, Camille; McGee, Patricia; Kriebel, Richard M

2011-01-01

The characteristic profile of Millennial Generation students, driving many educational reforms, can be challenged by research in a number of fields including cognition, learning style, neurology, and psychology. This evidence suggests that the current aggregate view of the Millennial student may be less than accurate. Statistics show that Millennial students are considerably diverse in backgrounds, personalities, and learning styles. Data are presented regarding technological predilection, multitasking, reading, critical thinking, professional behaviors, and learning styles, which indicate that students in the Millennial Generation may not be as homogenous in fundamental learning strategies and attitudes as is regularly proposed. Although their common character traits have implications for instruction, no available evidence demonstrates that these traits impact their fundamental process of learning. Many curricular strategies have been implemented to address alleged changes in the manner by which Millennial students learn. None has clearly shown superior outcomes in academic accomplishments or developing expertise for graduating students and concerns persist related to the successful engagement of Millennial students in the process of learning. Four factors for consideration in general curricular design are proposed to address student engagement and optimal knowledge acquisition for 21st century learners. Copyright © 2011 American Association of Anatomists.

Importance and use of correlational research.

PubMed

Curtis, Elizabeth A; Comiskey, Catherine; Dempsey, Orla

2016-07-01

The importance of correlational research has been reported in the literature yet few research texts discuss design in any detail. To discuss important issues and considerations in correlational research, and suggest ways to avert potential problems during the preparation and application of the design. This article targets the gap identified in the literature regarding correlational research design. Specifically, it discusses the importance and purpose of correlational research, its application, analysis and interpretation with contextualisations to nursing and health research. Findings from correlational research can be used to determine prevalence and relationships among variables, and to forecast events from current data and knowledge. In spite of its many uses, prudence is required when using the methodology and analysing data. To assist researchers in reducing mistakes, important issues are singled out for discussion and several options put forward for analysing data. Correlational research is widely used and this paper should be particularly useful for novice nurse researchers. Furthermore, findings generated from correlational research can be used, for example, to inform decision-making, and to improve or initiate health-related activities or change.

Integrating statistical and clinical research elements in intervention-related grant applications: summary from an NIMH workshop.

PubMed

Sherrill, Joel T; Sommers, David I; Nierenberg, Andrew A; Leon, Andrew C; Arndt, Stephan; Bandeen-Roche, Karen; Greenhouse, Joel; Guthrie, Donald; Normand, Sharon-Lise; Phillips, Katharine A; Shear, M Katherine; Woolson, Robert

2009-01-01

The authors summarize points for consideration generated in a National Institute of Mental Health (NIMH) workshop convened to provide an opportunity for reviewers from different disciplines-specifically clinical researchers and statisticians-to discuss how their differing and complementary expertise can be well integrated in the review of intervention-related grant applications. A 1-day workshop was convened in October, 2004. The workshop featured panel presentations on key topics followed by interactive discussion. This article summarizes the workshop and subsequent discussions, which centered on topics including weighting the statistics/data analysis elements of an application in the assessment of the application's overall merit; the level of statistical sophistication appropriate to different stages of research and for different funding mechanisms; some key considerations in the design and analysis portions of applications; appropriate statistical methods for addressing essential questions posed by an application; and the role of the statistician in the application's development, study conduct, and interpretation and dissemination of results. A number of key elements crucial to the construction and review of grant applications were identified. It was acknowledged that intervention-related studies unavoidably involve trade-offs. Reviewers are helped when applications acknowledge such trade-offs and provide good rationale for their choices. Clear linkage among the design, aims, hypotheses, and data analysis plan and avoidance of disconnections among these elements also strengthens applications. The authors identify multiple points to consider when constructing intervention-related grant applications. The points are presented here as questions and do not reflect institute policy or comprise a list of best practices, but rather represent points for consideration.

A Comprehensive Tool for Exploring the Availability, Scalability and Growth Potential of Conventional and Renewable Energy Sources and Technologies

NASA Astrophysics Data System (ADS)

Jack-Scott, E.; Arnott, J. C.; Katzenberger, J.; Davis, S. J.; Delman, E.

2015-12-01

It has been a generational challenge to simultaneously meet the world's energy requirements, while remaining within the bounds of acceptable cost and environmental impact. To this end, substantial research has explored various energy futures on a global scale, leaving decision-makers and the public overwhelmed by information on energy options. In response, this interactive energy table was developed as a comprehensive resource through which users can explore the availability, scalability, and growth potentials of all energy technologies currently in use or development. Extensive research from peer-reviewed papers and reports was compiled and summarized, detailing technology costs, technical considerations, imminent breakthroughs, and obstacles to integration, as well as political, social, and environmental considerations. Energy technologies fall within categories of coal, oil, natural gas, nuclear, solar, wind, hydropower, ocean, geothermal and biomass. In addition to 360 expandable cells of cited data, the interactive table also features educational windows with background information on each energy technology. The table seeks not to advocate for specific energy futures, but to succinctly and accurately centralize peer-reviewed research and information in an interactive, accessible resource. With this tool, decision-makers, researchers and the public alike can explore various combinations of energy technologies and their quantitative and qualitative attributes that can satisfy the world's total primary energy supply (TPES) while making progress towards a near zero carbon future.

Reprioritizing Research Activity for the Post-Antibiotic Era: Ethical, Legal, and Social Considerations.

PubMed

Hey, Spencer Phillips; Kesselheim, Aaron S

2017-03-01

Many hold that the so-called golden era of antibiotic discovery has passed, leaving only a limited clinical pipeline for new antibiotics. A logical conclusion of such arguments is that we need to reform the current system of antibiotic drug research-including clinical trials and regulatory requirements-to spur activity in discovery and development. The United States Congress in the past few years has debated a number of bills to address this crisis, including the 2012 Generating Antibiotic Incentives Now Act and the 2016 21st Century Cures Act. Experts have also sought to advance antibiotic development by encouraging greater use of trials with noninferiority hypotheses, which are thought to be easier to conduct. The goal underlying these proposals is to stave off the post-antibiotic era by expanding the pharmaceutical armamentarium as quickly as possible. But although new antibiotic agents are necessary to combat the long-term threat of drug-resistant disease, we argue that these research policies, which effectively lower the bar for antibiotic approval, are ethically problematic. Rather, given broader public health considerations related to the full lifecycle of antibiotic use-including development of resistance-we should reject an overly permissive approach to new antibiotic approval and instead set the bar for regulatory approval at a point that will naturally direct research resources toward the most transformative chemical or social interventions. © 2017 The Hastings Center.

Performance Factors Related to the Different Tennis Backhand Groundstrokes: A Review

PubMed Central

Genevois, Cyril; Reid, Machar; Rogowski, Isabelle; Crespo, Miguel

2015-01-01

The backhand is one of the two basic groundstrokes in tennis and can be played both with one or two hands, with topspin or backspin. Despite its variety of derivatives, the scientific literature describing the backhand groundstroke production has not been reviewed as extensively as with the serve and the forehand. The purpose of this article is to review the research describing the mechanics of one and two-handed backhands, with a critical focus on its application to clinicians and coaches. One hundred and thirty four articles satisfied a key word search (tennis, backhand) in relevant databases and manual search, with only 61 of those articles considered directly relevant to our review. The consensus of this research supports major differences between both the one- and two-handed strokes, chiefly about their respective contributions of trunk rotation and the role of the non-dominant upper extremity. Two-handed backhand strokes rely more on trunk rotation for the generation of racquet velocity, while the one-handed backhands utilize segmental rotations of the upper limb to develop comparable racquet speeds. There remains considerable scope for future research to examine expertise, age and/or gender-related kinematic differences to strengthen the practitioner’s understanding of the key mechanical considerations that may shape the development of proficient backhand strokes. Key points One-and two-handed backhands require different motor coordination Two-handed backhand strokes rely more on trunk rotation for racquet velocity generation, whereas one-handed backhand strokes rely more on segmental rotations of the upper limb Players using a two-handed backhand should learn early a slice one-handed backhand because of the different co-ordination pattern involved Equipment scaling is a great tool for coaches to learn early proper one-handed backhand strokes Future research related to the interaction between backhand technique, gender and skill level is needed PMID:25729308

A study using a Monte Carlo method of the optimal configuration of a distribution network in terms of power loss sensing.

PubMed

Moon, Hyun Ho; Lee, Jong Joo; Choi, Sang Yule; Cha, Jae Sang; Kang, Jang Mook; Kim, Jong Tae; Shin, Myong Chul

2011-01-01

Recently there have been many studies of power systems with a focus on "New and Renewable Energy" as part of "New Growth Engine Industry" promoted by the Korean government. "New And Renewable Energy"-especially focused on wind energy, solar energy and fuel cells that will replace conventional fossil fuels-is a part of the Power-IT Sector which is the basis of the SmartGrid. A SmartGrid is a form of highly-efficient intelligent electricity network that allows interactivity (two-way communications) between suppliers and consumers by utilizing information technology in electricity production, transmission, distribution and consumption. The New and Renewable Energy Program has been driven with a goal to develop and spread through intensive studies, by public or private institutions, new and renewable energy which, unlike conventional systems, have been operated through connections with various kinds of distributed power generation systems. Considerable research on smart grids has been pursued in the United States and Europe. In the United States, a variety of research activities on the smart power grid have been conducted within EPRI's IntelliGrid research program. The European Union (EU), which represents Europe's Smart Grid policy, has focused on an expansion of distributed generation (decentralized generation) and power trade between countries with improved environmental protection. Thus, there is current emphasis on a need for studies that assesses the economic efficiency of such distributed generation systems. In this paper, based on the cost of distributed power generation capacity, calculations of the best profits obtainable were made by a Monte Carlo simulation. Monte Carlo simulations that rely on repeated random sampling to compute their results take into account the cost of electricity production, daily loads and the cost of sales and generate a result faster than mathematical computations. In addition, we have suggested the optimal design, which considers the distribution loss associated with power distribution systems focus on sensing aspect and distributed power generation.

Biosynthesis, degradation and pharmacological importance of the fatty acid amides.

PubMed

Farrell, Emma K; Merkler, David J

2008-07-01

The identification of two biologically active fatty acid amides, N-arachidonoylethanolamine (anandamide) and oleamide, has generated a great deal of excitement and stimulated considerable research. However, anandamide and oleamide are merely the best-known and best-understood members of a much larger family of biologically occurring fatty acid amides. In this review, we will outline which fatty acid amides have been isolated from mammalian sources, detail what is known about how these molecules are made and degraded in vivo, and highlight their potential for the development of novel therapeutics.

Biosynthesis, degradation, and pharmacological importance of the fatty acid amides

PubMed Central

Farrell, Emma K.; Merkler, David J.

2008-01-01

The identification of two biologically active fatty acid amides, N-arachidonoylethanolamine (anandamide) and oleamide, has generated a great deal of excitement and stimulated considerable research. However, anandamide and oleamide are merely the best-known and best-understood members of a much larger family of biologically-occurring fatty acid amides. In this review, we will outline which fatty acid amides have been isolated from mammalian sources, detail what is known about how these molecules are made and degraded in vivo, and highlight their potential for the development of novel therapeutics. PMID:18598910

Computational Fluid Dynamics Symposium on Aeropropulsion

NASA Technical Reports Server (NTRS)

1991-01-01

Recognizing the considerable advances that have been made in computational fluid dynamics, the Internal Fluid Mechanics Division of NASA Lewis Research Center sponsored this symposium with the objective of providing a forum for exchanging information regarding recent developments in numerical methods, physical and chemical modeling, and applications. This conference publication is a compilation of 4 invited and 34 contributed papers presented in six sessions: algorithms one and two, turbomachinery, turbulence, components application, and combustors. Topics include numerical methods, grid generation, chemically reacting flows, turbulence modeling, inlets, nozzles, and unsteady flows.

Structural Health Monitoring System Trade Space Analysis Tool with Consideration for Crack Growth, Sensor Degradation and a Variable Detection Threshold

DTIC Science & Technology

2014-09-18

Erdogan , 1963). 26 Paris’s Law Under a fatigue stress regime Paris’s Law relates sub-critical crack growth to stress intensity factor. The basic...Paris and Erdogan , 1963). After takeoff, the model generates a probability distribution for the crack length in that specific sortie based on the...Law is one of the most widely used fatigue crack growth models and was used in this research effort (Paris and Erdogan , 1963). Paris’s Law Under a

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dickerson, James Henry

We have had considerable success on this project, particularly in the understanding of the relationship between nanostructure and magnetic properties in lanthanide nanocrystals. We also have successfully facilitated the doctoral degrees of Dr. Suseela Somarajan, in the Department of Physics and Astronomy, and Dr. Melissa Harrison, in the Materials Science Program. The following passages summarize the various accomplishments that were featured in 9 publications that were generated based on support from this grant. We thank the Department of Energy for their generous support of our research efforts in this area of materials science, magnetism, and electron microscopy.

T700 power turbine rotor multiplane/multispeed balancing demonstration

NASA Technical Reports Server (NTRS)

Burgess, G.; Rio, R.

1979-01-01

Research was conducted to demonstrate the ability of influence coefficient based multispeed balancing to control rotor vibration through bending criticals. Rotor dynamic analyses were conducted of the General Electric T700 power turbine rotor. The information was used to generate expected rotor behavior for optimal considerations in designing a balance rig and a balance technique. The rotor was successfully balanced 9500 rpm. Uncontrollable coupling behavior prevented observations through the 16,000 rpm service speed. The balance technique is practical and with additional refinement it can meet production standards.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ladendorff, Marlene Z.

Considerable money and effort has been expended by generation, transmission, and distribution entities in North America to implement the North American Electric Reliability Corporation (NERC) Critical Infrastructure Protection (CIP) standards for the bulk electric system. Assumptions have been made that as a result of the implementation of the standards, the grid is more cyber secure than it was pre-NERC CIP, but are there data supporting these claims, or only speculation? Has the implementation of the standards had an effect on the grid? Furthermore, developing a research study to address these and other questions provided surprising results.

Identification of translational dermatology research priorities in the U.K.: results of an electronic Delphi exercise.

PubMed

Healy, E; Brown, S J; Langan, S M; Nicholls, S G; Shams, K; Reynolds, N J

2015-11-01

Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders. © 2015 British Association of Dermatologists.

Identification of Translational Dermatology Research Priorities in the UK; Results of an e-Delphi Exercise

PubMed Central

Healy, E.; Reynolds, N.J.

2016-01-01

Summary Background Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2,000 different skin diseases, thus there are considerable challenges in seeking to undertake research on each of these disorders. Objective This eDelphi exercise was conducted in order to generate a list of translational dermatology research questions which are regarded as a priority for further investigations. Results During the first phase of the eDelphi, 228 research questions were generated by an expert panel which included clinical academic dermatologists, clinical dermatologists, non-clinical scientists, dermatology trainees and representatives from patient support groups. Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders / genodermatoses, 37 questions on skin cancer and 8 miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma (SCC) and melanoma), there were a number of cross-cutting themes which identified a need to investigate mechanisms / pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusion It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the UK and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of subjects with skin disorders. PMID:26149834

Medicine, methodology, and values: trade-offs in clinical science and practice.

PubMed

Ho, Vincent K Y

2011-01-01

The current guidelines of evidence-based medicine (EBM) presuppose that clinical research and clinical practice should advance from rigorous scientific tests as they generate reliable, value-free knowledge. Under this presupposition, hypotheses postulated by doctors and patients in the process of their decision making are preferably tested in randomized clinical trials (RCTs), and in systematic reviews and meta-analyses summarizing outcomes from multiple RCTs. Since testing under this scheme is predominantly focused on the criteria of generality and precision achieved through methodological rigor, at the cost of the criterion of realism, translating test results to clinical practice is often problematic. Choices concerning which methodological criteria should have priority are inevitable, however, as clinical trials, and scientific research in general, cannot meet all relevant criteria at the same time. Since these choices may be informed by considerations external to science, we must acknowledge that science cannot be value-free in a strict sense, and this invites a more prominent role for value-laden considerations in evaluating clinical research. The urgency for this becomes even more apparent when we consider the important yet implicit role of scientific theories in EBM, which may also be subjected to methodological evaluation and for which selectiveness in methodological focus is likewise inevitable.

Potential uses of spent mushroom substrate and its associated lignocellulosic enzymes.

PubMed

Phan, Chia-Wei; Sabaratnam, Vikineswary

2012-11-01

Mushroom industries generate a virtually in-exhaustible supply of a co-product called spent mushroom substrate (SMS). This is the unutilised substrate and the mushroom mycelium left after harvesting of mushrooms. As the mushroom industry is steadily growing, the volume of SMS generated annually is increasing. In recent years, the mushroom industry has faced challenges in storing and disposing the SMS. The obvious solution is to explore new applications of SMS. There has been considerable discussion recently about the potentials of using SMS for production of value-added products. One of them is production of lignocellulosic enzymes such as laccase, xylanase, lignin peroxidase, cellulase and hemicellulase. This paper reviews scientific research and practical applications of SMS as a readily available and cheap source of enzymes for bioremediation, animal feed and energy feedstock.

Strategies to address participant misrepresentation for eligibility in Web-based research.

PubMed

Kramer, Jessica; Rubin, Amy; Coster, Wendy; Helmuth, Eric; Hermos, John; Rosenbloom, David; Moed, Rich; Dooley, Meghan; Kao, Ying-Chia; Liljenquist, Kendra; Brief, Deborah; Enggasser, Justin; Keane, Terence; Roy, Monica; Lachowicz, Mark

2014-03-01

Emerging methodological research suggests that the World Wide Web ("Web") is an appropriate venue for survey data collection, and a promising area for delivering behavioral intervention. However, the use of the Web for research raises concerns regarding sample validity, particularly when the Web is used for recruitment and enrollment. The purpose of this paper is to describe the challenges experienced in two different Web-based studies in which participant misrepresentation threatened sample validity: a survey study and an online intervention study. The lessons learned from these experiences generated three types of strategies researchers can use to reduce the likelihood of participant misrepresentation for eligibility in Web-based research. Examples of procedural/design strategies, technical/software strategies and data analytic strategies are provided along with the methodological strengths and limitations of specific strategies. The discussion includes a series of considerations to guide researchers in the selection of strategies that may be most appropriate given the aims, resources and target population of their studies. Copyright © 2014 John Wiley & Sons, Ltd.

Entry System Design Considerations for Mars Landers

NASA Technical Reports Server (NTRS)

Lockwood, Mary Kae; Powell, Richard W.; Graves, Claude A.; Carman, Gilbert L.

2001-01-01

The objective for the next generation or Mars landers is to enable a safe landing at specific locations of scientific interest. The 1st generation entry, descent and landing systems, ex. Viking and Pathfinder, provided successful landing on Mars but by design were limited to large scale, 100s of km, landing sites with minimal local hazards. The 2 nd generation landers, or smart landers, will provide scientists with access to previously unachievable landing sites by providing precision landing to less than 10 km of a target landing site, with the ability to perform local hazard avoidance, and provide hazard tolerance. This 2nd generation EDL system can be utilized for a range of robotic missions with vehicles sized for science payloads from the small 25-70 kg, Viking, Pathfinder, Mars Polar Lander and Mars Exploration Rover-class, to the large robotic Mars Sample Return, 300 kg plus, science payloads. The 2nd generation system can also be extended to a 3nd generation EDL system with pinpoint landing, 10's of meters of landing accuracy, for more capable robotic or human missions. This paper will describe the design considerations for 2nd generation landers. These landers are currently being developed by a consortium of NASA centers, government agencies, industry and academic institutions. The extension of this system and additional considerations required for a 3nd generation human mission to Mars will be described.

Qualitative Research in Emergency Care Part I: Research Principles and Common Applications.

PubMed

Choo, Esther K; Garro, Aris C; Ranney, Megan L; Meisel, Zachary F; Morrow Guthrie, Kate

2015-09-01

Qualitative methods are increasingly being used in emergency care research. Rigorous qualitative methods can play a critical role in advancing the emergency care research agenda by allowing investigators to generate hypotheses, gain an in-depth understanding of health problems or specific populations, create expert consensus, and develop new intervention and dissemination strategies. This article, Part I of a two-article series, provides an introduction to general principles of applied qualitative health research and examples of its common use in emergency care research, describing study designs and data collection methods most relevant to our field, including observation, individual interviews, and focus groups. In Part II of this series, we will outline the specific steps necessary to conduct a valid and reliable qualitative research project, with a focus on interview-based studies. These elements include building the research team, preparing data collection guides, defining and obtaining an adequate sample, collecting and organizing qualitative data, and coding and analyzing the data. We also discuss potential ethical considerations unique to qualitative research as it relates to emergency care research. © 2015 by the Society for Academic Emergency Medicine.

Qualitative Research in Emergency Care Part I: Research Principles and Common Applications

PubMed Central

Choo, Esther K.; Garro, Aris; Ranney, Megan L.; Meisel, Zachary; Guthrie, Kate Morrow

2015-01-01

Qualitative methods are increasingly being used in emergency care research. Rigorous qualitative methods can play a critical role in advancing the emergency care research agenda by allowing investigators to generate hypotheses, gain an in-depth understanding of health problems or specific populations, create expert consensus, and develop new intervention and dissemination strategies. This article, Part I of a two-article series, provides an introduction to general principles of applied qualitative health research and examples of its common use in emergency care research, describing study designs and data collection methods most relevant to our field, including observation, individual interviews, and focus groups. In Part II of this series, we will outline the specific steps necessary to conduct a valid and reliable qualitative research project, with a focus on interview-based studies. These elements include building the research team, preparing data collection guides, defining and obtaining an adequate sample, collecting and organizing qualitative data, and coding and analyzing the data. We also discuss potential ethical considerations unique to qualitative research as it relates to emergency care research. PMID:26284696

Thermophotovoltaic potential applications for civilian and industrial use in Japan

NASA Astrophysics Data System (ADS)

Yamaguchi, Hiromi; Yamaguchi, Masafumi

1999-03-01

Investigative research on potential market for TPV power sources in Japan has been focused on how TPV can contribute to energy conservation and environmental protection and harmony. The application needs for TPV were surveyed in comparison with conventional engine or turbine generators and developing power generation technologies such as fuel cells or chemical batteries, etc. The investigation on the performance of commercial generators shows that regarding system efficiency, TPV can compete with conventional generators in the output power class of tens of kW. According to the sales for small scale generators in Japan, most of the generators below 10 kW class are utilized mainly for construction, communication, leisure, and that 10-100 kW class generators are for cogeneration in small buildings. Waste heat recovery in dispersed furnaces is another potential application of compact TPV cells. Exhaust heat from small scale incinerators and industrial furnaces is undesirable to be recorded into electricity due to excessive heat loss of the smaller steam turbine generators. Solar powered TPV is also of our concern as a natural energy use. From the viewpoint of applicability for TPV, portable generators cogeneration systems, and solar power plants were selected for our system consideration. Intermediate report on the feasibility study concerning such TPV systems is given as well as the review of the current status of competing power generation technologies in Japan.

The levels of analysis revisited

PubMed Central

MacDougall-Shackleton, Scott A.

2011-01-01

The term levels of analysis has been used in several ways: to distinguish between ultimate and proximate levels, to categorize different kinds of research questions and to differentiate levels of reductionism. Because questions regarding ultimate function and proximate mechanisms are logically distinct, I suggest that distinguishing between these two levels is the best use of the term. Integrating across levels in research has potential risks, but many benefits. Consideration at one level can help generate novel hypotheses at the other, define categories of behaviour and set criteria that must be addressed. Taking an adaptationist stance thus strengthens research on proximate mechanisms. Similarly, it is critical for researchers studying adaptation and function to have detailed knowledge of proximate mechanisms that may constrain or modulate evolutionary processes. Despite the benefits of integrating across ultimate and proximate levels, failure to clearly identify levels of analysis, and whether or not hypotheses are exclusive alternatives, can create false debates. Such non-alternative hypotheses may occur between or within levels, and are not limited to integrative approaches. In this review, I survey different uses of the term levels of analysis and the benefits of integration, and highlight examples of false debate within and between levels. The best integrative biology reciprocally uses ultimate and proximate hypotheses to generate a more complete understanding of behaviour. PMID:21690126

Senior academic physicians and retirement considerations.

PubMed

Moss, Arthur J; Greenberg, Henry; Dwyer, Edward M; Klein, Helmut; Ryan, Daniel; Francis, Charles; Marcus, Frank; Eberly, Shirley; Benhorin, Jesaia; Bodenheimer, Monty; Brown, Mary; Case, Robert; Gillespie, John; Goldstein, Robert; Haigney, Mark; Krone, Ronald; Lichstein, Edgar; Locati, Emanuela; Oakes, David; Thomsen, Poul Erik Bloch; Zareba, Wojciech

2013-01-01

An increasing number of academic senior physicians are approaching their potential retirement in good health with accumulated clinical and research experience that can be a valuable asset to an academic institution. Considering the need to let the next generation ascend to leadership roles, when and how should a medical career be brought to a close? We explore the roles for academic medical faculty as they move into their senior years and approach various retirement options. The individual and institutional considerations require a frank dialogue among the interested parties to optimize the benefits while minimizing the risks for both. In the United States there is no fixed age for retirement as there is in Europe, but European physicians are initiating changes. What is certain is that careful planning, innovative thinking, and the incorporation of new patterns of medical practice are all part of this complex transition and timing of senior academic physicians into retirement. Copyright © 2013 Elsevier Inc. All rights reserved.

Understanding men's health and illness: a gender-relations approach to policy, research, and practice.

PubMed

Schofield, T; Connell, R W; Walker, L; Wood, J F; Butland, D L

2000-05-01

Men's health has emerged as an important public concern that may require new kinds of healthcare interventions and increased resources. Considerable uncertainty and confusion surround prevailing understandings of men's health, particularly those generated by media debate and public policy, and health research has often operated on oversimplified assumptions about men and masculinity. A more useful way of understanding men's health is to adopt a gender-relations approach. This means examining health concerns in the context of men's and women's interactions with each other, and their positions in the larger, multidimensional structure of gender relations. Such an approach raises the issue of differences among men, which is a key issue in recent research on masculinity and an important health issue. The gender-relations approach offers new ways of addressing practical issues of healthcare for men in college environments.

Adolescent Peer Relations and Socioemotional Development in Latin America: Translating International Theory into Local Research.

PubMed

Berger, Christian; Lisboa, Carolina; Cuadros, Olga; de Tezanos-Pinto, Pablo

2016-06-01

Peer relations constitute a main developmental context for adolescents. Peers offer an instance for identity definition and set the norms of acceptable and valued characteristics, behaviors, and attitudes, representing a societal model that allows and restrains avenues for adolescents' socioemotional development. The present article departs from these considerations to review research on adolescents' peer relations in Latin America from a socioemotional perspective. First, approaches to adolescence are discussed, with a main focus on attachment and identity theories, based on a bioecological framework. Then, a review of research in Latin America on friendships, school climate, and intergroup relations is presented. The discussion addresses the tension between theories and evidence generated in developed societies and highlights the particularities of Latin American youth, stressing the need for collecting local data. © 2016 Wiley Periodicals, Inc.

Silicon Era of Carbon-Based Life: Application of Genomics and Bioinformatics in Crop Stress Research

PubMed Central

Li, Man-Wah; Qi, Xinpeng; Ni, Meng; Lam, Hon-Ming

2013-01-01

Abiotic and biotic stresses lead to massive reprogramming of different life processes and are the major limiting factors hampering crop productivity. Omics-based research platforms allow for a holistic and comprehensive survey on crop stress responses and hence may bring forth better crop improvement strategies. Since high-throughput approaches generate considerable amounts of data, bioinformatics tools will play an essential role in storing, retrieving, sharing, processing, and analyzing them. Genomic and functional genomic studies in crops still lag far behind similar studies in humans and other animals. In this review, we summarize some useful genomics and bioinformatics resources available to crop scientists. In addition, we also discuss the major challenges and advancements in the “-omics” studies, with an emphasis on their possible impacts on crop stress research and crop improvement. PMID:23759993

Toward a nosology of human aggressive behavior.

PubMed

Eichelman, B; Hartwig, A

1993-01-01

General attempts have been made to catalog or categorize research literature on aggressive behavior. In the animal literature this category has been delineated by clearly observed and described patterns of behavior. These include offensive and defensive expressions in animals and the characterization of attack behaviors by typography into defensive and offensive. The human literature is considerably deficient in the description and categorization of human aggressive behavior. Current nosologies offer no utilitarian schema for characterizing violent behavior in clinical populations regarding the typography of the violence, its prediction, or guidance as to its treatment. The generation of databased nosologies may provide a mechanism for the development of research and clinically relevant nosologies based upon cluster analyses of treatment outcomes and behavioral characteristics. This strategy may provide a more effective approach for further research concerning clinical aggressive or destructive behaviors.

Materials for a new generation of vehicles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grobstein, T.

1995-12-31

The Partnership for a New Generation of Vehicles (PNGV) is a national initiative with three goals: first, to significantly improve national competitiveness in manufacturing; second, to implement commercially viable innovations from ongoing research on conventional vehicles, and third, to develop a vehicle to achieve up to three times the fuel efficiency of today`s comparable vehicle (i.e., the 1994 Chrysler Concorde, Ford Taurus, and Chevrolet Lumina). Note this vehicle will have the equivalent customer purchase price of today`s vehicles adjusted for economics, while meeting the customers` needs for quality, performance, and utility. Eight federal agencies are currently contributing to these goals,more » as well as the three principal US automobile manufacturers, numerous automotive component suppliers, research laboratories, and universities. Materials research and development is a significant effort within PNGV. The goals in this area include development of lightweight, recyclable materials for structural applications, high strength, long-life, high temperature materials for engine components, improved materials for alternative propulsion and energy storage systems, and cost-effective process technologies and component fabrication methods. Application of advanced materials to automobiles will involve consideration of diverse factors, including weight savings, affordability, recyclability, crashworthiness, repairability, and manufacturability.« less

Conceptual Design of In-Space Vehicles for Human Exploration of the Outer Planets

NASA Technical Reports Server (NTRS)

Adams, R. B.; Alexander, R. A.; Chapman, J. M.; Fincher, S. S.; Hopkins, R. C.; Philips, A. D.; Polsgrove, T. T.; Litchford, R. J.; Patton, B. W.; Statham, G.

2003-01-01

During FY-2002, a team of engineers from TD30/Advanced Concepts and TD40/Propulsion Research Center embarked on a study of potential crewed missions to the outer solar system. The study was conducted under the auspices of the Revolutionary Aerospace Systems Concepts activity administered by Langley Research Center (LaRC). The Marshall Space Flight Center (MSFC) team interacted heavily with teams from other Centers including Glenn Research Center, LaRC, Jet Propulsion Laboratory, and Johnson Space Center. The MSFC team generated five concept missions for this project. The concept missions use a variety of technologies, including magnetized target fusion (MTF), magnetoplasmadynamic thrusters, solid core reactors, and molten salt reactors in various combinations. The Technical Publication (TP) reviews these five concepts and the methods used to generate them. The analytical methods used are described for all significant disciplines and subsystems. The propulsion and power technologies selected for each vehicle are reviewed in detail. The MSFC team also expended considerable effort refining the MTF concept for use with this mission. The results from this effort are also contained within this TP. Finally, the lessons learned from this activity are summarized in the conclusions section.

Renewable generation technology choice and policies in a competitive electricity supply industry

NASA Astrophysics Data System (ADS)

Sarkar, Ashok

Renewable energy generation technologies have lower externality costs but higher private costs than fossil fuel-based generation. As a result, the choice of renewables in the future generation mix could be affected by the industry's future market-oriented structure because market objectives based on private value judgments may conflict with social policy objectives toward better environmental quality. This research assesses how renewable energy generation choices would be affected in a restructured electricity generation market. A multi-period linear programming-based model (Resource Planning Model) is used to characterize today's electricity supply market in the United States. The model simulates long-range (2000-2020) generation capacity planning and operation decisions under alternative market paradigms. Price-sensitive demand is used to simulate customer preferences in the market. Dynamically changing costs for renewables and a two-step load duration curve are used. A Reference Case represents the benchmark for a socially-optimal diffusion of renewables and a basis for comparing outcomes under alternative market structures. It internalizes externality costs associated with emissions of sulfur dioxide (SOsb2), nitrous oxides (NOsbx), and carbon dioxide (COsb2). A Competitive Case represents a market with many generation suppliers and decision-making based on private costs. Finally, a Market Power Case models the extreme case of market power: monopoly. The results suggest that the share of renewables would decrease (and emissions would increase) considerably in both the Competitive and the Market Power Cases with respect to the Reference Case. The reduction is greater in the Market Power Case due to pricing decisions under existing supply capability. The research evaluates the following environmental policy options that could overcome market failures in achieving an appropriate level of renewable generation: COsb2 emissions tax, SOsb2 emissions cap, renewable portfolio standards (RPS), and enhanced research and development (R&D). RPS would best ensure an appropriate share of renewables, whereas SOsb2 emissions caps would not support a shift to renewables in an era of inexpensive natural gas. The effectiveness of the policies are dependent on the market structure. If market power exists, the analyses indicate that generally higher levels of intervention would be necessary to achieve a shift to renewables.

Interview-based Qualitative Research in Emergency Care Part II: Data Collection, Analysis and Results Reporting.

PubMed

Ranney, Megan L; Meisel, Zachary F; Choo, Esther K; Garro, Aris C; Sasson, Comilla; Morrow Guthrie, Kate

2015-09-01

Qualitative methods are increasingly being used in emergency care research. Rigorous qualitative methods can play a critical role in advancing the emergency care research agenda by allowing investigators to generate hypotheses, gain an in-depth understanding of health problems or specific populations, create expert consensus, and develop new intervention and dissemination strategies. In Part I of this two-article series, we provided an introduction to general principles of applied qualitative health research and examples of its common use in emergency care research, describing study designs and data collection methods most relevant to our field (observation, individual interviews, and focus groups). Here in Part II of this series, we outline the specific steps necessary to conduct a valid and reliable qualitative research project, with a focus on interview-based studies. These elements include building the research team, preparing data collection guides, defining and obtaining an adequate sample, collecting and organizing qualitative data, and coding and analyzing the data. We also discuss potential ethical considerations unique to qualitative research as it relates to emergency care research. © 2015 by the Society for Academic Emergency Medicine.

Interview-Based Qualitative Research in Emergency Care Part II: Data Collection, Analysis and Results Reporting

PubMed Central

Ranney, Megan L.; Meisel, Zachary; Choo, Esther K.; Garro, Aris; Sasson, Comilla; Morrow, Kathleen

2015-01-01

Qualitative methods are increasingly being used in emergency care research. Rigorous qualitative methods can play a critical role in advancing the emergency care research agenda by allowing investigators to generate hypotheses, gain an in-depth understanding of health problems or specific populations, create expert consensus, and develop new intervention and dissemination strategies. In Part I of this two-article series, we provided an introduction to general principles of applied qualitative health research and examples of its common use in emergency care research, describing study designs and data collection methods most relevant to our field (observation, individual interviews, and focus groups). Here in Part II of this series, we outline the specific steps necessary to conduct a valid and reliable qualitative research project, with a focus on interview-based studies. These elements include building the research team, preparing data collection guides, defining and obtaining an adequate sample, collecting and organizing qualitative data, and coding and analyzing the data. We also discuss potential ethical considerations unique to qualitative research as it relates to emergency care research. PMID:26284572

Human Genome Editing and Ethical Considerations.

PubMed

Krishan, Kewal; Kanchan, Tanuj; Singh, Bahadur

2016-04-01

Editing human germline genes may act as boon in some genetic and other disorders. Recent editing of the genome of the human embryo with the CRISPR/Cas9 editing tool generated a debate amongst top scientists of the world for the ethical considerations regarding its effect on the future generations. It needs to be seen as to what transformation human gene editing brings to humankind in the times to come.

Study design elements for rigorous quasi-experimental comparative effectiveness research.

PubMed

Maciejewski, Matthew L; Curtis, Lesley H; Dowd, Bryan

2013-03-01

Quasi-experiments are likely to be the workhorse study design used to generate evidence about the comparative effectiveness of alternative treatments, because of their feasibility, timeliness, affordability and external validity compared with randomized trials. In this review, we outline potential sources of discordance in results between quasi-experiments and experiments, review study design choices that can improve the internal validity of quasi-experiments, and outline innovative data linkage strategies that may be particularly useful in quasi-experimental comparative effectiveness research. There is an urgent need to resolve the debate about the evidentiary value of quasi-experiments since equal consideration of rigorous quasi-experiments will broaden the base of evidence that can be brought to bear in clinical decision-making and governmental policy-making.

Atmospheric effects of stratospheric aircraft: An evaluation of NASA's interim assessment

NASA Technical Reports Server (NTRS)

1994-01-01

The advent of high-speed civil transport aircraft (HSCT's) some 25 years ago generated considerable concern about potential impacts on the stratosphere. With interest in such aircraft again increasing, NASA initiated an assessment of the potential stratospheric impacts of a substantial increase in the use of HSCT's. This assessment was intended to examine, from the standpoint of present scientific understanding, the potential atmospheric impacts of a fleet of high-speed civil transports flying supersonically in the lower stratosphere. The program was initiated in 1991, and the bulk of its research is scheduled to be completed in 1995. In early 1993 NASA asked the National Research Council to review its efforts. This report documents its findings and recommendations.

Picture This... Safety, Dignity, and Voice-Ethical Research with Children: Practical Considerations for the Reflexive Researcher

ERIC Educational Resources Information Center

Phelan, Shanon K.; Kinsella, Elizabeth Anne

2013-01-01

While engaged in a research project involving the use of visual methods with children, the authors discovered that there are many ethical considerations beyond what could have been predicted at the outset. Some of these considerations are important with respect to research with children in general, while others arise more particularly when using…

Life Science on the International Space Station Using the Next Generation of Cargo Vehicles

NASA Technical Reports Server (NTRS)

Robinson, J. A.; Phillion, J. P.; Hart, A. T.; Comella, J.; Edeen, M.; Ruttley, T. M.

2011-01-01

With the retirement of the Space Shuttle and the transition of the International Space Station (ISS) from assembly to full laboratory capabilities, the opportunity to perform life science research in space has increased dramatically, while the operational considerations associated with transportation of the experiments has changed dramatically. US researchers have allocations on the European Automated Transfer Vehicle (ATV) and Japanese H-II Transfer Vehicle (HTV). In addition, the International Space Station (ISS) Cargo Resupply Services (CRS) contract will provide consumables and payloads to and from the ISS via the unmanned SpaceX (offers launch and return capabilities) and Orbital (offers only launch capabilities) resupply vehicles. Early requirements drove the capabilities of the vehicle providers; however, many other engineering considerations affect the actual design and operations plans. To better enable the use of the International Space Station as a National Laboratory, ground and on-orbit facility development can augment the vehicle capabilities to better support needs for cell biology, animal research, and conditioned sample return. NASA Life scientists with experience launching research on the space shuttle can find the trades between the capabilities of the many different vehicles to be confusing. In this presentation we will summarize vehicle and associated ground processing capabilities as well as key concepts of operations for different types of life sciences research being launched in the cargo vehicles. We will provide the latest status of vehicle capabilities and support hardware and facilities development being made to enable the broadest implementation of life sciences research on the ISS.

Laser Ignition Technology for Bi-Propellant Rocket Engine Applications

NASA Technical Reports Server (NTRS)

Thomas, Matthew E.; Bossard, John A.; Early, Jim; Trinh, Huu; Dennis, Jay; Turner, James (Technical Monitor)

2001-01-01

The fiber optically coupled laser ignition approach summarized is under consideration for use in igniting bi-propellant rocket thrust chambers. This laser ignition approach is based on a novel dual pulse format capable of effectively increasing laser generated plasma life times up to 1000 % over conventional laser ignition methods. In the dual-pulse format tinder consideration here an initial laser pulse is used to generate a small plasma kernel. A second laser pulse that effectively irradiates the plasma kernel follows this pulse. Energy transfer into the kernel is much more efficient because of its absorption characteristics thereby allowing the kernel to develop into a much more effective ignition source for subsequent combustion processes. In this research effort both single and dual-pulse formats were evaluated in a small testbed rocket thrust chamber. The rocket chamber was designed to evaluate several bipropellant combinations. Optical access to the chamber was provided through small sapphire windows. Test results from gaseous oxygen (GOx) and RP-1 propellants are presented here. Several variables were evaluated during the test program, including spark location, pulse timing, and relative pulse energy. These variables were evaluated in an effort to identify the conditions in which laser ignition of bi-propellants is feasible. Preliminary results and analysis indicate that this laser ignition approach may provide superior ignition performance relative to squib and torch igniters, while simultaneously eliminating some of the logistical issues associated with these systems. Further research focused on enhancing the system robustness, multiplexing, and window durability/cleaning and fiber optic enhancements is in progress.

36 CFR 242.16 - Customary and traditional use determination process.

Code of Federal Regulations, 2013 CFR

2013-07-01

... generation to generation; (7) A pattern of use in which the harvest is shared or distributed within a... storing fish or wildlife which has been traditionally used by past generations, including consideration of...

A writer's guide to education scholarship: Qualitative education scholarship (part 2).

PubMed

Chan, Teresa M; Ting, Daniel K; Hall, Andrew Koch; Murnaghan, Aleisha; Thoma, Brent; McEwen, Jill; Yarris, Lalena M

2018-03-01

Education scholarship can be conducted using a variety of methods, from quantitative experiments to qualitative studies. Qualitative methods are less commonly used in emergency medicine (EM) education research but are well-suited to explore complex educational problems and generate hypotheses. We aimed to review the literature to provide resources to guide educators who wish to conduct qualitative research in EM education. We conducted a scoping review to outline: 1) a list of journals that regularly publish qualitative educational papers; 2) an aggregate set of quality markers for qualitative educational research and scholarship; and 3) a list of quality checklists for qualitative educational research and scholarship. We found nine journals that have published more than one qualitative educational research paper in EM. From the literature, we identified 39 quality markers that were grouped into 10 themes: Initial Grounding Work (preparation, background); Goals, Problem Statement, or Question; Methods (general considerations); Sampling Techniques; Data Collection Techniques; Data Interpretation and Theory Generation; Measures to Optimize Rigour and Trustworthiness; Relevance to the Field; Evidence of Reflective Practice; Dissemination and Reporting. Lastly, five quality checklists were found for guiding educators in reporting their qualitative work. Many problems that EM educators face are well-suited to exploration using qualitative methods. The results of our scoping review provide publication venues, quality indicators, and checklists that may be useful to EM educators embarking on qualitative projects.

Is It Better to Burn or Bury Waste for Clean Electricity Generation?

EPA Science Inventory

The generation of electricity through renewables has increased 5% since 2002. Although considerably less prominent than solar and wind, the use of municipal solid waste (MSW) to generate electricity represents roughly 14 percent of U.S. non-hydro renewable electricity generation....

Rhetoric, power and legitimacy: a critical analysis of the public policy disputes surrounding stem cell research in Australia (2005-6).

PubMed

Lysaght, Tamra; Kerridge, Ian

2012-02-01

In December 2006, the Australian Parliament liberalized regulation governing stem cell research. This decision and preceding legislative review generated considerable public debate, which centred on objections to the deliberate creation and destruction of human embryos for research purposes. This paper draws on qualitative research conducted on the public debate surrounding this policy episode. The aim of this research was to examine how science and scientific knowledge are mobilized by participants in these debates to support their arguments. Data were collected from 109 newspaper opinion editorials as well as 23 in-depth interviews and examined using qualitative content and thematic analysis. Results of this analysis depict science as a rhetorical, moral and political resource that provides opportunities for participants to gain legitimacy, negotiate meaning and assert authority in the public domain. The mobilization of science in public discourse is discussed along with suggestions that are aimed at encouraging greater transparency and inclusiveness in public debates around contested science and emergent technologies.

NCAR's Experimental Real-time Convection-allowing Ensemble Prediction System

NASA Astrophysics Data System (ADS)

Schwartz, C. S.; Romine, G. S.; Sobash, R.; Fossell, K.

2016-12-01

Since April 2015, the National Center for Atmospheric Research's (NCAR's) Mesoscale and Microscale Meteorology (MMM) Laboratory, in collaboration with NCAR's Computational Information Systems Laboratory (CISL), has been producing daily, real-time, 10-member, 48-hr ensemble forecasts with 3-km horizontal grid spacing over the conterminous United States (http://ensemble.ucar.edu). These computationally-intensive, next-generation forecasts are produced on the Yellowstone supercomputer, have been embraced by both amateur and professional weather forecasters, are widely used by NCAR and university researchers, and receive considerable attention on social media. Initial conditions are supplied by NCAR's Data Assimilation Research Testbed (DART) software and the forecast model is NCAR's Weather Research and Forecasting (WRF) model; both WRF and DART are community tools. This presentation will focus on cutting-edge research results leveraging the ensemble dataset, including winter weather predictability, severe weather forecasting, and power outage modeling. Additionally, the unique design of the real-time analysis and forecast system and computational challenges and solutions will be described.

An Update to Returning Genetic Research Results to Individuals: Perspectives of the Industry Pharmacogenomics Working Group

PubMed Central

Prucka, Sandra K; Arnold, Lester J; Brandt, John E; Gilardi, Sandra; Harty, Lea C; Hong, Feng; Malia, Joanne; Pulford, David J

2015-01-01

The ease with which genotyping technologies generate tremendous amounts of data on research participants has been well chronicled, a feat that continues to become both faster and cheaper to perform. In parallel to these advances come additional ethical considerations and debates, one of which centers on providing individual research results and incidental findings back to research participants taking part in genetic research efforts. In 2006 the Industry Pharmacogenomics Working Group (I-PWG) offered some ‘Points-to-Consider’ on this topic within the context of the drug development process from those who are affiliated to pharmaceutical companies. Today many of these points remain applicable to the discussion but will be expanded upon in this updated viewpoint from the I-PWG. The exploratory nature of pharmacogenomic work in the pharmaceutical industry is discussed to provide context for why these results typically are not best suited for return. Operational challenges unique to this industry which cause barriers to returning this information are also explained. PMID:24471556

Characterization of a spontaneously generated murine retinal pigmented epithelium cell line; a model for in vitro experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ranaei Pirmardan, Ehsan; Soheili, Zahra-Soheila; Samiei, Shahram

Retinal pigmented epithelium (RPE), the outermost layer of the retina, has a key role in maintaining retinal cells’ functions. Severity of the culture of RPE cells has exerted many limitations to both in vitro and in vivo studies and its therapeutic applications. Therefore, establishment of RPE cell lines with high proliferative potential can considerably improve study of RPE cell biology. Here we report generation of a spontaneously immortalized murine RPE cell line in primary mouse RPE cell culture. Founded colonized cells were picked up and expression of RPE and retinal progenitor cells’ (RPC) markers were studied using immunocytochemistry (ICC). Emergedmore » cells cultured over 35 passages and population doubling times in different serum concentrations were calculated. We also investigated the ability of cells for becoming transfected by calcium-phosphate method and for becoming infected by adeno-associated virus serotype 2 (AAV2) using flow cytometry. Data showed that the cobblestone constituent cells expressed RPE65, cytokeratin and ZO1 and moreover several progenitor markers such as Pax6, Sox2, Nestin and Chx10. It revealed that, despite primary RPE cells, the newly emerged cells were easily transfectable and were highly infectable when compared with HEK293T cells. Our data indicated that the emerged mouse RPE cell line pretended RPC-like phenotype and also simultaneously expressed RPE markers. It would be a promising model for leading studies on RPE and RPC cells and substantially confirmed the great RPE plasticity and its invaluable potential in research studies. - Highlights: • Isolation of a spontaneously generated retinal pigmented epithelium cell line is reported. • The cells express some of the retinal progenitor cell markers in addition to the RPE markers. • The aforesaid cell line is highly transfecable and considerably infectable by AAV2. • These results confirm the great RPE plasticity and its invaluable potential in research studies.« less

Photovoltaic central station step and touch potential considerations in grounding system design

NASA Technical Reports Server (NTRS)

Engmann, G.

1983-01-01

The probability of hazardous step and touch potentials is an important consideration in central station grounding system design. Steam turbine generating station grounding system design is based on accepted industry practices and there is extensive in-service experience with these grounding systems. A photovoltaic (PV) central station is a relatively new concept and there is limited experience with PV station grounding systems. The operation and physical configuration of a PV central station is very different from a steam electric station. A PV station bears some similarity to a substation and the PV station step and touch potentials might be addressed as they are in substation design. However, the PV central station is a generating station and it is appropriate to examine the effect that the differences and similarities of the two types of generating stations have on step and touch potential considerations.

Relationship between microstructure and mechanical properties of Alloy 690 tubes for steam generators

NASA Astrophysics Data System (ADS)

Diano, P.; Muggeo, A.; Van Duysen, J. C.; Guttmann, M.

1989-12-01

Alloy 690 is used to replace Alloy 600 for the fabrication of tubes for steam generators of french pressurized water nuclear reactors. In order to reduce the dispersion in tensile properties observed for the first Alloy 690 industrial tubes, and which had already been noticed for Alloy 600, a joint research programme has been carried out by Electricité de France (Département Etude des Matériaux) and Valinox Montbard. The dispersion in the tensile properties of the first industrial Alloy 690 tubes for PWR steam generators arises from two main factors: - a grain size dispersion which is in particular controlled by the carbon content and by the final heat treatment, - differences in the degree of strain hardening induced by the straightening process with rollers. An improvement of the fabrication processes which have an influence on these two factors has allowed to reduce considerably the dispersion of the tensile properties of the more recent series of tubes.

Comprehensive evaluation of non-hybrid genome assembly tools for third-generation PacBio long-read sequence data.

PubMed

Jayakumar, Vasanthan; Sakakibara, Yasubumi

2017-11-03

Long reads obtained from third-generation sequencing platforms can help overcome the long-standing challenge of the de novo assembly of sequences for the genomic analysis of non-model eukaryotic organisms. Numerous long-read-aided de novo assemblies have been published recently, which exhibited superior quality of the assembled genomes in comparison with those achieved using earlier second-generation sequencing technologies. Evaluating assemblies is important in guiding the appropriate choice for specific research needs. In this study, we evaluated 10 long-read assemblers using a variety of metrics on Pacific Biosciences (PacBio) data sets from different taxonomic categories with considerable differences in genome size. The results allowed us to narrow down the list to a few assemblers that can be effectively applied to eukaryotic assembly projects. Moreover, we highlight how best to use limited genomic resources for effectively evaluating the genome assemblies of non-model organisms. © The Author 2017. Published by Oxford University Press.

The roles of family, culture, and social cognitive variables in the career interests and goals of Asian American college students.

PubMed

Hui, Kayi; Lent, Robert W

2018-01-01

Although family and cultural factors have been assumed to play important roles in the career development of Asian Americans, theory-driven research on this topic remains limited. We examined culturally relevant factors that may contribute to Asian Americans' consideration of fields in which they are overrepresented (e.g., science, technology, engineering) and underrepresented (e.g., education, social science). Drawing from social cognitive career theory, a culture-specific, social cognitive model of career interests and choice was tested in Holland's (1997) Investigative (I) and Social (S) themes. A sample of 802 Asian American undergraduates completed measures of family support, self-efficacy, outcome expectations, interest, and career choice consideration in relation to both Holland themes. Two indicators of acculturation/enculturation (adherence to Asian values and generation status in the United States) were also obtained. The model accounted for a substantial amount of variance in Asian American college students' career consideration in both themes. Family support and acculturation played varying roles, depending on the Holland theme. For example, family support was linked to career choice consideration both directly (in the S theme) and indirectly, via other predictors (in both themes). Contrary to expectations, the acculturation variables did not moderate the relation of family support or interest to career consideration in either theme. We discuss the implications of these findings for efforts to understand and facilitate the career development of Asian American college students. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

VAMPS: a website for visualization and analysis of microbial population structures.

PubMed

Huse, Susan M; Mark Welch, David B; Voorhis, Andy; Shipunova, Anna; Morrison, Hilary G; Eren, A Murat; Sogin, Mitchell L

2014-02-05

The advent of next-generation DNA sequencing platforms has revolutionized molecular microbial ecology by making the detailed analysis of complex communities over time and space a tractable research pursuit for small research groups. However, the ability to generate 10⁵-10⁸ reads with relative ease brings with it many downstream complications. Beyond the computational resources and skills needed to process and analyze data, it is difficult to compare datasets in an intuitive and interactive manner that leads to hypothesis generation and testing. We developed the free web service VAMPS (Visualization and Analysis of Microbial Population Structures, http://vamps.mbl.edu) to address these challenges and to facilitate research by individuals or collaborating groups working on projects with large-scale sequencing data. Users can upload marker gene sequences and associated metadata; reads are quality filtered and assigned to both taxonomic structures and to taxonomy-independent clusters. A simple point-and-click interface allows users to select for analysis any combination of their own or their collaborators' private data and data from public projects, filter these by their choice of taxonomic and/or abundance criteria, and then explore these data using a wide range of analytic methods and visualizations. Each result is extensively hyperlinked to other analysis and visualization options, promoting data exploration and leading to a greater understanding of data relationships. VAMPS allows researchers using marker gene sequence data to analyze the diversity of microbial communities and the relationships between communities, to explore these analyses in an intuitive visual context, and to download data, results, and images for publication. VAMPS obviates the need for individual research groups to make the considerable investment in computational infrastructure and bioinformatic support otherwise necessary to process, analyze, and interpret massive amounts of next-generation sequence data. Any web-capable device can be used to upload, process, explore, and extract data and results from VAMPS. VAMPS encourages researchers to share sequence and metadata, and fosters collaboration between researchers of disparate biomes who recognize common patterns in shared data.

Adapting practice-based intervention research to electronic environments: opportunities and complexities at two institutions.

PubMed

Stille, Christopher J; Lockhart, Steven A; Maertens, Julie A; Madden, Christi A; Darden, Paul M

2015-01-01

Primary care practice-based research has become more complex with increased use of electronic health records (EHRs). Little has been reported about changes in study planning and execution that are required as practices change from paper-based to electronic-based environments. We describe the evolution of a pediatric practice-based intervention study as it was adapted for use in the electronic environment, to enable other practice-based researchers to plan efficient, effective studies. We adapted a paper-based pediatric office-level intervention to enhance parent-provider communication about subspecialty referrals for use in two practice-based research networks (PBRNs) with partially and fully electronic environments. We documented the process of adaptation and its effect on study feasibility and efficiency, resource use, and administrative and regulatory complexities, as the study was implemented in the two networks. Considerable time and money was required to adapt the paper-based study to the electronic environment, requiring extra meetings with institutional EHR-, regulatory-, and administrative teams, and increased practice training. Institutional unfamiliarity with using EHRs in practice-based research, and the consequent need to develop new policies, were major contributors to delays. Adapting intervention tools to the EHR and minimizing practice disruptions was challenging, but resulted in several efficiencies as compared with a paper-based project. In particular, recruitment and tracking of subjects and data collection were easier and more efficient. Practice-based intervention research in an electronic environment adds considerable cost and time at the outset of a study, especially for centers unfamiliar with such research. Efficiencies generated have the potential of easing the work of study enrollment, subject tracking, and data collection.

Recruitment of Yoruba families from Nigeria for genetic research: experience from a multisite keloid study

PubMed Central

2014-01-01

Background More involvement of sub-Saharan African countries in biomedical studies, specifically in genetic research, is needed to advance individualized medicine that will benefit non-European populations. Missing infrastructure, cultural and religious beliefs as well as lack of understanding of research benefits can pose a challenge to recruitment. Here we describe recruitment efforts for a large genetic study requiring three-generation pedigrees within the Yoruba homelands of Nigeria. The aim of the study was to identify genes responsible for keloids, a wound healing disorder. We also discuss ethical and logistical considerations that we encountered in preparation for this research endeavor. Methods Protocols for this bi-national intercultural study were approved by the Institutional Review Board (IRB) in the US and the ethics committees of the Nigerian institutions for consideration of cultural differences. Principles of community based participatory research were employed throughout the recruitment process. Keloid patients (patient advisors), community leaders, kings/chiefs and medical directors were engaged to assist the research teams with recruitment strategies. Community meetings, church forums, and media outlets (study flyers, radio and TV announcements) were utilized to promote the study in Nigeria. Recruitment of research participants was conducted by trained staff from the local communities. Pedigree structures were re-analyzed on a regular basis as new family members were recruited and recruitment challenges were documented. Results Total recruitment surpassed 4200 study participants over a 7-year period including 79 families with complete three-generation pedigrees. In 9 families more than 20 family members participated, however, in 5 of these families, we encountered issues with pedigree structure as members from different branches presented inconsistent family histories. These issues were due to the traditional open family structure amongst the Yoruba and by beliefs in voodoo or in juju. In addition, family members living in other parts of the country or abroad complicated timely and complete family recruitment. Conclusions Organizational, logistics and ethics challenges can be overcome by additional administrative efforts, good communication, community involvement and education of staff members. However, recruitment challenges due to infrastructural shortcomings or cultural and religious beliefs can lead to significant delays, which may negatively affect study time lines and expectations of funding agencies. PMID:25182071

Exploring evidence-policy linkages in health research plans: A case study from six countries

PubMed Central

Syed, Shamsuzzoha B; Hyder, Adnan A; Bloom, Gerald; Sundaram, Sandhya; Bhuiya, Abbas; Zhenzhong, Zhang; Kanjilal, Barun; Oladepo, Oladimeji; Pariyo, George; Peters, David H

2008-01-01

The complex evidence-policy interface in low and middle income country settings is receiving increasing attention. Future Health Systems (FHS): Innovations for Equity, is a research consortium conducting health systems explorations in six Asian and African countries: Bangladesh, India, China, Afghanistan, Uganda, and Nigeria. The cross-country research consortium provides a unique opportunity to explore the research-policy interface. Three key activities were undertaken during the initial phase of this five-year project. First, key considerations in strengthening evidence-policy linkages in health system research were developed by FHS researchers through workshops and electronic communications. Four key considerations in strengthening evidence-policy linkages are postulated: development context; research characteristics; decision-making processes; and stakeholder engagement. Second, these four considerations were applied to research proposals in each of the six countries to highlight features in the research plans that potentially strengthen the research-policy interface and opportunities for improvement. Finally, the utility of the approach for setting research priorities in health policy and systems research was reflected upon. These three activities yielded interesting findings. First, developmental consideration with four dimensions – poverty, vulnerabilities, capabilities, and health shocks – provides an entry point in examining research-policy interfaces in the six settings. Second, research plans focused upon on the ground realities in specific countries strengthens the interface. Third, focusing on research prioritized by decision-makers, within a politicized health arena, enhances chances of research influencing action. Lastly, early and continued engagement of multiple stakeholders, from local to national levels, is conducive to enhanced communication at the interface. The approach described has four main utilities: first, systematic analyses of research proposals using key considerations ensure such issues are incorporated into research proposals; second, the exact meaning, significance, and inter-relatedness of these considerations can be explored within the research itself; third, cross-country learning can be enhanced; and finally, translation of evidence into action may be facilitated. Health systems research proposals in low and middle income countries should include reflection on transferring research findings into policy. Such deliberations may be informed by employing the four key considerations suggested in this paper in analyzing research proposals. PMID:18331651

Optimizing the response to surveillance alerts in automated surveillance systems.

PubMed

Izadi, Masoumeh; Buckeridge, David L

2011-02-28

Although much research effort has been directed toward refining algorithms for disease outbreak alerting, considerably less attention has been given to the response to alerts generated from statistical detection algorithms. Given the inherent inaccuracy in alerting, it is imperative to develop methods that help public health personnel identify optimal policies in response to alerts. This study evaluates the application of dynamic decision making models to the problem of responding to outbreak detection methods, using anthrax surveillance as an example. Adaptive optimization through approximate dynamic programming is used to generate a policy for decision making following outbreak detection. We investigate the degree to which the model can tolerate noise theoretically, in order to keep near optimal behavior. We also evaluate the policy from our model empirically and compare it with current approaches in routine public health practice for investigating alerts. Timeliness of outbreak confirmation and total costs associated with the decisions made are used as performance measures. Using our approach, on average, 80 per cent of outbreaks were confirmed prior to the fifth day of post-attack with considerably less cost compared to response strategies currently in use. Experimental results are also provided to illustrate the robustness of the adaptive optimization approach and to show the realization of the derived error bounds in practice. Copyright © 2011 John Wiley & Sons, Ltd.

Sensing network for electromagnetic fields generated by seismic activities

NASA Astrophysics Data System (ADS)

Gershenzon, Naum I.; Bambakidis, Gust; Ternovskiy, Igor V.

2014-06-01

The sensors network is becoming prolific and play now increasingly more important role in acquiring and processing information. Cyber-Physical Systems are focusing on investigation of integrated systems that includes sensing, networking, and computations. The physics of the seismic measurement and electromagnetic field measurement requires special consideration how to design electromagnetic field measurement networks for both research and detection earthquakes and explosions along with the seismic measurement networks. In addition, the electromagnetic sensor network itself could be designed and deployed, as a research tool with great deal of flexibility, the placement of the measuring nodes must be design based on systematic analysis of the seismic-electromagnetic interaction. In this article, we review the observations of the co-seismic electromagnetic field generated by earthquakes and man-made sources such as vibrations and explosions. The theoretical investigation allows the distribution of sensor nodes to be optimized and could be used to support existing geological networks. The placement of sensor nodes have to be determined based on physics of electromagnetic field distribution above the ground level. The results of theoretical investigations of seismo-electromagnetic phenomena are considered in Section I. First, we compare the relative contribution of various types of mechano-electromagnetic mechanisms and then analyze in detail the calculation of electromagnetic fields generated by piezomagnetic and electrokinetic effects.

Considerations in video playback design: using optic flow analysis to examine motion characteristics of live and computer-generated animation sequences.

PubMed

Woo, Kevin L; Rieucau, Guillaume

2008-07-01

The increasing use of the video playback technique in behavioural ecology reveals a growing need to ensure better control of the visual stimuli that focal animals experience. Technological advances now allow researchers to develop computer-generated animations instead of using video sequences of live-acting demonstrators. However, care must be taken to match the motion characteristics (speed and velocity) of the animation to the original video source. Here, we presented a tool based on the use of an optic flow analysis program to measure the resemblance of motion characteristics of computer-generated animations compared to videos of live-acting animals. We examined three distinct displays (tail-flick (TF), push-up body rock (PUBR), and slow arm wave (SAW)) exhibited by animations of Jacky dragons (Amphibolurus muricatus) that were compared to the original video sequences of live lizards. We found no significant differences between the motion characteristics of videos and animations across all three displays. Our results showed that our animations are similar the speed and velocity features of each display. Researchers need to ensure that similar motion characteristics in animation and video stimuli are represented, and this feature is a critical component in the future success of the video playback technique.

Conceptualizing Telehealth in Nursing Practice: Advancing a Conceptual Model to Fill a Virtual Gap.

PubMed

Nagel, Daniel A; Penner, Jamie L

2016-03-01

Increasingly nurses use various telehealth technologies to deliver health care services; however, there has been a lag in research and generation of empirical knowledge to support nursing practice in this expanding field. One challenge to generating knowledge is a gap in development of a comprehensive conceptual model or theoretical framework to illustrate relationships of concepts and phenomena inherent to adoption of a broad range of telehealth technologies to holistic nursing practice. A review of the literature revealed eight published conceptual models, theoretical frameworks, or similar entities applicable to nursing practice. Many of these models focus exclusively on use of telephones and four were generated from qualitative studies, but none comprehensively reflect complexities of bridging nursing process and elements of nursing practice into use of telehealth. The purpose of this article is to present a review of existing conceptual models and frameworks, discuss predominant themes and features of these models, and present a comprehensive conceptual model for telehealth nursing practice synthesized from this literature for consideration and further development. This conceptual model illustrates characteristics of, and relationships between, dimensions of telehealth practice to guide research and knowledge development in provision of holistic person-centered care delivery to individuals by nurses through telehealth technologies. © The Author(s) 2015.

Direct detection of spin Nernst effect in platinum

NASA Astrophysics Data System (ADS)

Bose, A.; Bhuktare, S.; Singh, H.; Dutta, S.; Achanta, V. G.; Tulapurkar, A. A.

2018-04-01

Generation of spin current lies at the heart of spintronic research. The spin Hall effect and the spin Seebeck effect have drawn considerable attention in the last few years to create pure spin current by heavy metals and ferromagnets, respectively. In this work, we show the direct evidence of heat current to spin current conversion in non-magnetic Platinum by the spin Nernst effect (SNE) at room temperature. This is the thermal analogue of the spin Hall effect in non-magnets. We have shown that the 8 K/μm thermal gradient in Pt can lead to the generation of pure spin current density of the order of 108 A/m2 by virtue of SNE. This opens up an additional possibility to couple the relativistic spin-orbit interaction with the thermal gradient for spintronic applications.

Fatal and nonfatal risk associated with recycle of D&D-generated concrete

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boren, J.K.; Ayers, K.W.; Parker, F.L.

1997-02-01

As decontamination and decommissioning activities proceed within the U.S. Department of Energy Complex, vast volumes of uncontaminated and contaminated concrete will be generated. The current practice of decontaminating and landfilling the concrete is an expensive and potentially wasteful practice. Research is being conducted at Vanderbilt University to assess the economic, social, legal, and political ramifications of alternate methods of dealing with waste concrete. An important aspect of this research work is the assessment of risk associated with the various alternatives. A deterministic risk assessment model has been developed which quantifies radiological as well as non-radiological risks associated with concrete disposalmore » and recycle activities. The risk model accounts for fatal as well as non-fatal risks to both workers and the public. Preliminary results indicate that recycling of concrete presents potentially lower risks than the current practice. Radiological considerations are shown to be of minor importance in comparison to other sources of risk, with conventional transportation fatalities and injuries dominating. Onsite activities can also be a major contributor to non-fatal risk.« less

A simulation-based efficiency comparison of AC and DC power distribution networks in commercial buildings

DOE PAGES

Gerber, Daniel L.; Vossos, Vagelis; Feng, Wei; ...

2017-06-12

Direct current (DC) power distribution has recently gained traction in buildings research due to the proliferation of on-site electricity generation and battery storage, and an increasing prevalence of internal DC loads. The research discussed in this paper uses Modelica-based simulation to compare the efficiency of DC building power distribution with an equivalent alternating current (AC) distribution. The buildings are all modeled with solar generation, battery storage, and loads that are representative of the most efficient building technology. A variety of paramet ric simulations determine how and when DC distribution proves advantageous. These simulations also validate previous studies that use simplermore » approaches and arithmetic efficiency models. This work shows that using DC distribution can be considerably more efficient: a medium sized office building using DC distribution has an expected baseline of 12% savings, but may also save up to 18%. In these results, the baseline simulation parameters are for a zero net energy (ZNE) building that can island as a microgrid. DC is most advantageous in buildings with large solar capacity, large battery capacity, and high voltage distribution.« less

Arsenic waste management: a critical review of testing and disposal of arsenic-bearing solid wastes generated during arsenic removal from drinking water.

PubMed

Clancy, Tara M; Hayes, Kim F; Raskin, Lutgarde

2013-10-01

Water treatment technologies for arsenic removal from groundwater have been extensively studied due to widespread arsenic contamination of drinking water sources. Central to the successful application of arsenic water treatment systems is the consideration of appropriate disposal methods for arsenic-bearing wastes generated during treatment. However, specific recommendations for arsenic waste disposal are often lacking or mentioned as an area for future research and the proper disposal and stabilization of arsenic-bearing waste remains a barrier to the successful implementation of arsenic removal technologies. This review summarizes current disposal options for arsenic-bearing wastes, including landfilling, stabilization, cow dung mixing, passive aeration, pond disposal, and soil disposal. The findings from studies that simulate these disposal conditions are included and compared to results from shorter, regulatory tests. In many instances, short-term leaching tests do not adequately address the range of conditions encountered in disposal environments. Future research directions are highlighted and include establishing regulatory test conditions that align with actual disposal conditions and evaluating nonlandfill disposal options for developing countries.

A simulation-based efficiency comparison of AC and DC power distribution networks in commercial buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerber, Daniel L.; Vossos, Vagelis; Feng, Wei

Direct current (DC) power distribution has recently gained traction in buildings research due to the proliferation of on-site electricity generation and battery storage, and an increasing prevalence of internal DC loads. The research discussed in this paper uses Modelica-based simulation to compare the efficiency of DC building power distribution with an equivalent alternating current (AC) distribution. The buildings are all modeled with solar generation, battery storage, and loads that are representative of the most efficient building technology. A variety of paramet ric simulations determine how and when DC distribution proves advantageous. These simulations also validate previous studies that use simplermore » approaches and arithmetic efficiency models. This work shows that using DC distribution can be considerably more efficient: a medium sized office building using DC distribution has an expected baseline of 12% savings, but may also save up to 18%. In these results, the baseline simulation parameters are for a zero net energy (ZNE) building that can island as a microgrid. DC is most advantageous in buildings with large solar capacity, large battery capacity, and high voltage distribution.« less

[Identification and memorisation of emotions in Alzheimer's disease: a critical review of litterature].

PubMed

Morrone, Isabella; Besche-Richard, Chrystel; Mahmoudi, Rachid; Novella, Jean-Luc

2012-09-01

Although the first signs of Alzheimer's disease (AD) mainly affect episodic memory and executive functions, emotional disturbances also have a considerable impact on the mental and relational capacities of AD patients. In AD, the early impairment of amygdala structures, whose central role in the recognition and memorisation of emotions has previously been demonstrated, has led researchers to focus on the possible implications of such impairment in generating cognitive disturbances or behavioural troubles in these subjects. Several studies have shown that emotional processes are altered in AD, and can contribute to varying degrees to deficits in terms of social cognition, and to the generation of behavioural troubles. This review will detail the main avenues of research into the capacity to identify and memorise emotions in AD, and summarise the often conflicting results that have, to date, prevented the emergence of a general consensus concerning the emotional processes. It seems thereby legitimate to question about different elements that can explain these conflicting results, such as the existence of various theories, divergences about the definition of emotions and important methodological differences.

Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review.

PubMed

Talge, Nicole M; Tudor, Brooke M; Kileny, Paul R

2018-06-01

Behavior does not differentiate ASD risk prior to 12 months of age, but biomarkers may inform risk before symptoms emerge. Click-evoked auditory brainstem responses (ABRs) may be worth consideration due to their measurement properties (noninvasiveness; reliability) and conceptual features (well-characterized neural generators), but participant characteristics and assessment protocols vary considerably across studies. Our goal is to perform a meta-analysis of the association between ABRs and ASD. Following an electronic database search (PubMed, Medline, PsycInfo, PsycArticles), we included papers that were written in English, included ASD and typically-developing (TD) groups, and reported the information needed to calculate standardized mean differences (Hedges's g) for at least one ABR latency component (I, III, V, I-III, III-V, I-V). We weighted and averaged effect sizes across conditions and subsets of participants to yield one estimate per component per study. We then performed random-effects regressions to generate component-specific estimates. ASD was associated with longer ABR latencies for Waves III (g = 0.5, 95% CI 0.1, 0.9), V (g = 0.7, 95% CI 0.3, 1.1), I-III (g = 0.7, 95% CI 0.2, 1.2), and I-V (g = 0.6, 95% CI 0.2, 1.0). All components showed significant heterogeneity. Associations were strongest among participants ≤8 years of age and those without middle ear abnormalities or elevated auditory thresholds. In sum, associations between ABRs and ASD are medium-to-large in size, but exhibit heterogeneity. Identifying sources of heterogeneity is challenging, however, due to power limitations and co-occurrence of sample/design characteristics across studies. Research addressing the above limitations is crucial to determining the etiologic and/or prognostic value of ABRs for ASD. Autism Res 2018, 11: 916-927. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. Auditory brainstem responses (ABR) may be associated with ASD, but participant characteristics and assessment protocols vary considerably across individual studies. Our goal is to combine the results across these studies to facilitate clarity on the topic. Doing so represents a first step in evaluating whether ABRs yield potential for informing the etiology of ASD risk and/or ASD symptom profiles. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.

Generation of nanobubbles by ceramic membrane filters: The dependence of bubble size and zeta potential on surface coating, pore size and injected gas pressure.

PubMed

Ahmed, Ahmed Khaled Abdella; Sun, Cuizhen; Hua, Likun; Zhang, Zhibin; Zhang, Yanhao; Zhang, Wen; Marhaba, Taha

2018-07-01

Generation of gaseous nanobubbles (NBs) by simple, efficient, and scalable methods is critical for industrialization and applications of nanobubbles. Traditional generation methods mainly rely on hydrodynamic, acoustic, particle, and optical cavitation. These generation processes render issues such as high energy consumption, non-flexibility, and complexity. This research investigated the use of tubular ceramic nanofiltration membranes to generate NBs in water with air, nitrogen and oxygen gases. This system injects pressurized gases through a tubular ceramic membrane with nanopores to create NBs. The effects of membrane pores size, surface energy, and the injected gas pressures on the bubble size and zeta potential were examined. The results show that the gas injection pressure had considerable effects on the bubble size, zeta potential, pH, and dissolved oxygen of the produced NBs. For example, increasing the injection air pressure from 69 kPa to 414 kPa, the air bubble size was reduced from 600 to 340 nm respectively. Membrane pores size and surface energy also had significant effects on sizes and zeta potentials of NBs. The results presented here aim to fill out the gaps of fundamental knowledge about NBs and development of efficient generation methods. Copyright © 2018 Elsevier Ltd. All rights reserved.

Considerations for use of dental photography and electronic media in dental education and clinical practice.

PubMed

Stieber, Jane C; Nelson, Travis; Huebner, Colleen E

2015-04-01

Photography and electronic media are indispensable tools for dental education and clinical practice. Although previous research has focused on privacy issues and general strategies to protect patient privacy when sharing clinical photographs for educational purposes, there are no published recommendations for developing a functional, privacy-compliant institutional framework for the capture, storage, transfer, and use of clinical photographs and other electronic media. The aims of this study were to research patient rights relating to electronic media and propose a framework for the use of patient media in education and clinical care. After a review of the relevant literature and consultation with the University of Washington's director of privacy and compliance and assistant attorney general, the researchers developed a privacy-compliant framework to ensure appropriate capture, storage, transfer, and use of clinical photography and electronic media. A four-part framework was created to guide the use of patient media that reflects considerations of patient autonomy and privacy, informed consent, capture and storage of media, and its transfer, use, and display. The best practices proposed for capture, storage, transfer, and use of clinical photographs and electronic media adhere to the health care code of ethics (based on patient autonomy, nonmaleficence, beneficence, justice, and veracity), which is most effectively upheld by a practical framework designed to protect patients and limit institutional liability. Educators have the opportunity and duty to convey these principles to students who will become the next generation of dentists, researchers, and educators.

Copper Nanowires and Their Applications for Flexible, Transparent Conducting Films: A Review

PubMed Central

Nam, Vu Binh; Lee, Daeho

2016-01-01

Cu nanowires (NWs) are attracting considerable attention as alternatives to Ag NWs for next-generation transparent conductors, replacing indium tin oxide (ITO) and micro metal grids. Cu NWs hold great promise for low-cost fabrication via a solution-processed route and show preponderant optical, electrical, and mechanical properties. In this study, we report a summary of recent advances in research on Cu NWs, covering the optoelectronic properties, synthesis routes, deposition methods to fabricate flexible transparent conducting films, and their potential applications. This review also examines the approaches on protecting Cu NWs from oxidation in air environments. PMID:28344304

A Review of Cellularization Strategies for Tissue Engineering of Whole Organs

PubMed Central

Scarritt, Michelle E.; Pashos, Nicholas C.; Bunnell, Bruce A.

2015-01-01

With the advent of whole organ decellularization, extracellular matrix scaffolds suitable for organ engineering were generated from numerous tissues, including the heart, lung, liver, kidney, and pancreas, for use as alternatives to traditional organ transplantation. Biomedical researchers now face the challenge of adequately and efficiently recellularizing these organ scaffolds. Herein, an overview of whole organ decellularization and a thorough review of the current literature for whole organ recellularization are presented. The cell types, delivery methods, and bioreactors employed for recellularization are discussed along with commercial and clinical considerations, such as immunogenicity, biocompatibility, and Food and Drug Administartion regulation. PMID:25870857

Future HIV Mentoring Programs to Enhance Diversity.

PubMed

Stoff, David M; Cargill, Victoria A

2016-09-01

This paper proposes a general template to guide future mentoring program development addressing: (i) considerations to ensure an adequate research workforce; (ii) key guidelines and principles of mentoring; and (iii) use of a logic model to develop program milestones, outcomes and evaluation. We focus on these areas to guide and inform the most effective mentoring program components, which we find to be more helpful than identifying specific features and ingredients. Although the focus is on the development of a new generation of investigators from diverse backgrounds, this template may also apply to mentoring programs for other investigators and for disciplines beyond HIV.

Contemporary Australian outcomes in childhood and adolescent type 1 diabetes: 10 years post the Diabetes Control and Complications Trial.

PubMed

Ambler, Geoffrey R; Fairchild, Jan; Craig, Maria E; Cameron, Fergus J

2006-01-01

The reporting of the results of the Diabetes Control and Complications Trial in 1993 has led to a major reappraisal of management practices and outcomes in type 1 diabetes in children and adolescents. A considerable body of outcome data has been generated from Australia in this post-Diabetes Control and Complications Trial era relating to incidence, metabolic control, growth, hypoglycaemia, microvascular and macrovascular complications, cognition, behaviour and quality of life. These data are important in planning future management strategies and resource allocation and as a basis for future research.

Application of microplasma discharge in a spark gap for high repetitive switching

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rahaman, Hasibur; Nam, Sang Hoon; Nam, Jong Woo

2010-04-05

The electrical breakdown in a spark gap for repetitive switching has been a long research interest. For this purpose, microplasma discharge is implemented in the spark gap which is further integrated inside a coaxial transmission line. This work addresses important physical properties and insights of the microplasma discharge, to be optimized, such as plasma generation in a spark channel, dielectric recovery process, and residual plasma in the postspark discharge period. Although understanding the microplasma discharge is the primary goal, considerable attention has been focused on an external circuit scheme to drive the discharge system at a high repetition rate.

An overview of polymer ageing studies in the nuclear power industry

NASA Astrophysics Data System (ADS)

Burnay, S. G.

2001-12-01

Polymeric components are widely used in nuclear power plants (NPPs) in equipment which is important to the safety of the plant. The degradation of such components is therefore of considerable interest to the industry and its regulatory bodies, generating a large number of studies worldwide. Some of these components need to remain functional over the full operational life of the plant, which may span up to 60 years. Predictive modelling of their behaviour is therefore of key importance. This paper outlines the main areas of research, particularly relating to the use of elastomeric seals and polymeric cable insulation in NPP.

On the Measurement of the Electrical Power Produced by Melt Spun Piezoelectric Textile Fibres

NASA Astrophysics Data System (ADS)

Matsouka, Dimitroula; Vassiliadis, Savvas; Prekas, Kleanthis; Bayramol, Derman Vatansever; Soin, Navneet; Siores, Elias

2016-10-01

Piezoelectric, melt spun, textile fibres as multifunctional materials appeared recently, and they are under thorough investigation and testing in order to define their performance and behaviour. Although piezoelectricity was first reported in 1880 and the piezoelectric behaviour of organic polymers materials has been known since 1969, the fibrous form of the piezoelectric materials under consideration opens new technological horizons; however, it introduces novel restrictions and further complex parameters are involved in their study. The major issue of the current research work is the study of the actual capacity of the piezoelectric fibres, i.e. the electric power produced following mechanical stimulation of the individual fibre. The measurements were made possible after the development of the necessary specific equipment. The test results enabled the ranking of the various types of the piezoelectric fibres according to the respective power generation. The main difference in this research approach is the measurement of the power generated by the fibres. Measurement of the power generated by an electrical power source (in the case of energy harvesting applications which is the prime interest of this research project) is an important characteristic as the requirements of various applications are expressed in units of power. Stating the voltage produced during mechanical deformation of the fibres is not enough (cf. voltage produced due to electrostatic phenomena on textiles where the voltage is in the range is the several kV, but the power is not enough to power a light-emitting diode).

Models of Consent to Return of Incidental Findings in Genomic Research

PubMed Central

Appelbaum, Paul S.; Parens, Erik; Waldman, Cameron R.; Klitzman, Robert; Fyer, Abby; Martinez, Josue; Price, W. Nicholson; Chung, Wendy K.

2014-01-01

Genomic research has the capacity to generate a wide array of findings that go beyond the goals of the study—usually referred to as “incidental findings.” The evolving consensus of researchers, participants, and expert panels is that at least some incidental results should be made available to participants. However, there are a number of challenges to discussing these issues with participants and ascertaining their preferences, including the complexity and magnitude of the relevant information. Believing that usual models of informed consent are not likely to be effective in this context, we identify four approaches that investigators and IRBs might consider: traditional consent, staged consent, mandatory return, and outsourcing. Each has advantages and disadvantages compared with the other options, and which one is selected for a given project will depend on a mix of practical and normative considerations that are described in this paper. PMID:24919982

A field ornithologist’s guide to genomics: Practical considerations for ecology and conservation

USGS Publications Warehouse

Oyler-McCance, Sara J.; Oh, Kevin; Langin, Kathryn; Aldridge, Cameron L.

2016-01-01

Vast improvements in sequencing technology have made it practical to simultaneously sequence millions of nucleotides distributed across the genome, opening the door for genomic studies in virtually any species. Ornithological research stands to benefit in three substantial ways. First, genomic methods enhance our ability to parse and simultaneously analyze both neutral and non-neutral genomic regions, thus providing insight into adaptive evolution and divergence. Second, the sheer quantity of sequence data generated by current sequencing platforms allows increased precision and resolution in analyses. Third, high-throughput sequencing can benefit applications that focus on a small number of loci that are otherwise prohibitively expensive, time-consuming, and technically difficult using traditional sequencing methods. These advances have improved our ability to understand evolutionary processes like speciation and local adaptation, but they also offer many practical applications in the fields of population ecology, migration tracking, conservation planning, diet analyses, and disease ecology. This review provides a guide for field ornithologists interested in incorporating genomic approaches into their research program, with an emphasis on techniques related to ecology and conservation. We present a general overview of contemporary genomic approaches and methods, as well as important considerations when selecting a genomic technique. We also discuss research questions that are likely to benefit from utilizing high-throughput sequencing instruments, highlighting select examples from recent avian studies.

A perspective on reagent diversity and non-covalent binding of reactive carbonyl species (RCS) and effector reagents in nonenzymatic glycation (NEG): Mechanistic considerations and implications for future research

NASA Astrophysics Data System (ADS)

Rodnick, Kenneth J.; Holman, R. W.; Ropski, Pamela S.; Huang, Mingdong; Swislocki, Arthur L. M.

2017-06-01

This perspective focuses on illustrating the underappreciated connections between reactive carbonyl species (RCS), initial binding in the nonenzymatic glycation (NEG) process, and nonenzymatic covalent protein modification (here termed NECPM). While glucose is the central species involved in NEG, recent studies indicate that the initially-bound glucose species in the NEG of human hemoglobin (HbA) and human serum albumin (HSA) are non-RCS ring-closed isomers. The ring-opened glucose, an RCS structure that reacts in the NEG process, is most likely generated from previously-bound ring-closed isomers undergoing concerted acid/base reactions while bound to protein. The generation of the glucose RCS can involve concomitantly-bound physiological species (e.g., inorganic phosphate, water, etc.); here termed effector reagents. Extant NEG schemes do not account for these recent findings. In addition, effector reagent reactions with glucose in the serum and erythrocyte cytosol can generate RCS (e.g., glyoxal, glyceraldehyde, etc.). Recent research has shown that these RCS covalently modify proteins in vivo via NECPM mechanisms. A general scheme that reflects both the reagent and mechanistic diversity that can lead to NEG and NECPM is presented here. A perspective that accounts for the relationships between RCS, NEG, and NECPM can facilitate the understanding of site selectivity, may help explain overall glycation rates, and may have implications for the clinical assessment/control of diabetes mellitus. In view of this perspective, concentrations of ribose, fructose, Pi, bicarbonate, counter ions, and the resulting RCS generated within intracellular and extracellular compartments may be of importance and of clinical relevance. Future research is also proposed.

Surface effects on the thermal conductivity of silicon nanowires

NASA Astrophysics Data System (ADS)

Li, Hai-Peng; Zhang, Rui-Qin

2018-03-01

Thermal transport in silicon nanowires (SiNWs) has recently attracted considerable attention due to their potential applications in energy harvesting and generation and thermal management. The adjustment of the thermal conductivity of SiNWs through surface effects is a topic worthy of focus. In this paper, we briefly review the recent progress made in this field through theoretical calculations and experiments. We come to the conclusion that surface engineering methods are feasible and effective methods for adjusting nanoscale thermal transport and may foster further advancements in this field. Project supported by the National Natural Science Foundation ofChina (Grant No. 11504418), China Scholarship Council (Grant No. 201706425053), Basic Research Program in Shenzhen, China (Grant No. JCYJ20160229165210666), and the Fundamental Research Funds for the Central Universities of China (Grant No. 2015XKMS075).

Gendered innovations: a new approach for nursing science.

PubMed

Sims, Stacy T; Stefanick, Marcia L; Kronenberg, Fredi; Sachedina, Nishma A; Schiebinger, Londa

2010-10-01

Considerable sex and gender bias has been recognized within the field of medicine. Investigators have used sex and gender analysis to reevaluate studies and outcomes and generate new perspectives and new questions regarding differential diagnoses and treatments of men and women. Sex and gender analysis acts as an experimental control to provide critical scientific rigor; researchers who ignore it risk ignoring a possible source of error in past, current, and future science. In this article, the authors introduce some tools of sex and gender analysis and illustrate the concept of gendered innovations by demonstrating through examples how this type of analysis has profoundly enhanced human knowledge in health and disease. The authors also provide recommendations for incorporating the concepts of sex and gender analysis into nursing education and research.

Considerations for preparing collaborative international research: a Ugandan experience.

PubMed

Musil, Carol M; Mutabaazi, Jemimah; Walusimbi, Mariam; Okonsky, Jennifer G; Biribonwa, Yedidah; Eagan, Sabrina; Dimarco, Marguerite A; Mbaballi, Speciosa; Fitzpatrick, Joyce J

2004-08-01

This article describes issues to consider when planning and conducting international research projects. Key considerations include building collaboration, developing a comprehensive and feasible research plan, funding and budgets, addressing human subjects concerns, and analyzing and disseminating project findings. These considerations and related methodological issues are discussed in the context of a replication pilot project conducted outside Kampala, Uganda. Ongoing dialog, flexibility, and collaboration, in addition to good science, are critical to developing successful international research projects.

Effects of disciplinary cultures of researchers and research trainees on the acceptability of nanocarriers for drug delivery in different contexts of use: a mixed-methods study

NASA Astrophysics Data System (ADS)

Chenel, Vanessa; Boissy, Patrick; Cloarec, Jean-Pierre; Patenaude, Johane

2015-04-01

The acceptability of nanomedical applications, which have the potential to generate ethical and societal impacts, is a significant factor in the deployment of nanomedicine. A lack of fit between nanomedical applications and society's values may result from a partial consideration of such impacts. New approaches for technological evaluation focused on impact perception, acceptance, and acceptability are needed to go beyond traditional technology assessment approaches used with nanotechnology, which focus mainly on toxicological and safety criteria. Using a new evaluative approach based on perceived impacts of nanotechnology, the objective of this study was to assess perceptions among researchers and research trainees familiar with emergent technologies and from different disciplinary background the scope of acceptability judgments made towards the use of nanocarriers. This mixed-methods study was based on scenarios presenting two types of drug-delivery nanocarriers (carbon, synthetic DNA) in two contexts of use (lung cancer treatment, seasonal flu treatment). Researchers and research trainees in the natural sciences and engineering, and the social sciences and the humanities were invited by email to take part in this project. An online questionnaire followed by semi-directed interviews allowed characterization of disciplinary divergences regarding to impact perception, acceptance, and acceptability of the scenarios. The results suggest that impact perception is influenced by disciplinary culture. Also, trends can be seen between respondents' profiles and variables of acceptance and acceptability, and certain components of the acceptability judgement are specific to each disciplinary culture. The acknowledgment and consideration of these disciplinary divergences could allow, among others, for opening up interdisciplinary dialogue on matters related to the acceptability of nanomedical applications and their developments.

Effects of disciplinary cultures of researchers and research trainees on the acceptability of nanocarriers for drug delivery in different contexts of use: a mixed-methods study.

PubMed

Chenel, Vanessa; Boissy, Patrick; Cloarec, Jean-Pierre; Patenaude, Johane

The acceptability of nanomedical applications, which have the potential to generate ethical and societal impacts, is a significant factor in the deployment of nanomedicine. A lack of fit between nanomedical applications and society's values may result from a partial consideration of such impacts. New approaches for technological evaluation focused on impact perception, acceptance, and acceptability are needed to go beyond traditional technology assessment approaches used with nanotechnology, which focus mainly on toxicological and safety criteria. Using a new evaluative approach based on perceived impacts of nanotechnology, the objective of this study was to assess perceptions among researchers and research trainees familiar with emergent technologies and from different disciplinary background the scope of acceptability judgments made towards the use of nanocarriers. This mixed-methods study was based on scenarios presenting two types of drug-delivery nanocarriers (carbon, synthetic DNA) in two contexts of use (lung cancer treatment, seasonal flu treatment). Researchers and research trainees in the natural sciences and engineering, and the social sciences and the humanities were invited by email to take part in this project. An online questionnaire followed by semi-directed interviews allowed characterization of disciplinary divergences regarding to impact perception, acceptance, and acceptability of the scenarios. The results suggest that impact perception is influenced by disciplinary culture. Also, trends can be seen between respondents' profiles and variables of acceptance and acceptability, and certain components of the acceptability judgement are specific to each disciplinary culture. The acknowledgment and consideration of these disciplinary divergences could allow, among others, for opening up interdisciplinary dialogue on matters related to the acceptability of nanomedical applications and their developments.

Impact of space research and technology on small countries

NASA Astrophysics Data System (ADS)

Serafimov, K. B.

Space research has generated and stimulated development in the following five ways: influence on other sciences; space technology transfer and spin-offs; rocket industry, direct use of space (communications, remote sensing, meteorology, navigation, etc.); growing interest towards education, science and creative work, increased prestige, etc. The necessity of small and developing countries to participate in space research has been recognized. Their role in international space cooperation has been pointed out. A number of problems have been presented for the small countries related to their adequate engagement in space research activities, as well as some considerations and conclusions in respect to their participation in space research, such as: creating their own `space specialization', optimal choice of participation in international projects and programmes, ensurance of financing, material and technical foundation and other possibilities; active participation in COPEOS, COSPAR, IAF and other space organizations. Some possible negative features in the space activities of small countries have been shown, and a brief review is given as an example of Bulgaria's participation in space research. Some possibilities of help to small and developing countries by COSPAR and IAF are analyzed.

Leveraging school-based research to inform bullying prevention and policy.

PubMed

Espelage, Dorothy L

2016-11-01

School-based bullying and other forms of school violence have been the topic of over 40 years of research in the U.S. and internationally. Within the last 2 decades, research has increasingly informed bullying prevention, policy, and legislative efforts. The purpose of this article is to highlight several critical research areas on bullying and other forms of school violence that have shaped prevention efforts and policy over the last 2 decades. As the recipient of the 2016 Award for Distinguished Contributions to Research in Public Policy , the discussion here will focus largely on research findings from The Espelage Lab and collaborators, but these studies and findings will be situated in the larger literature. Topics covered include conceptualization of bullying from a social-ecological framework, developmental considerations of bullying and associated forms of aggression, identification of populations at heightened risk for bullying, and efficacy of bullying prevention programs. Recommendations are provided for the next generation of scholars, practitioners, and policymakers focused on bullying prevention. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

Use of bioreactors in maxillofacial tissue engineering.

PubMed

Depprich, Rita; Handschel, Jörg; Wiesmann, Hans-Peter; Jäsche-Meyer, Janine; Meyer, Ulrich

2008-07-01

Engineering of various oral tissues is a challenging issue in contemporary maxillofacial reconstructive research. In contrast to the classic biomaterial approach, tissue engineering is based on the understanding of cell driven tissue formation, and aims to generate new functional tissues, rather than just to implant non-living space holders. Researchers hope to reach this goal by combining knowledge from biology, physics, materials science, engineering, and medicine in an integrated manner. Several major technical advances have been made in this field during the last decade, and clinical application is at the stage of first clinical trials. A recent limitation of extracorporally engineered cellular substitutes is the problem of growing enlarged tissues ex vivo. One of the main research topics is therefore to scale up artificial tissue constructs for use in extended defect situations. To overcome the monolayer inherent two-dimensional cell assembly, efforts have been made to grow cells in a three-dimensional space. Bioreactors have therefore been in focus for a considerable time to build up enlarged tissues. The shift from the ex vivo approach of cell multiplication to the generation of a real tissue growth is mirrored by the development of bioreactors, enabling scientists to grow more complex tissue constructs. This present review intends to provide an overview of the current state of art in maxillofacial tissue engineering by the use of bioreactors, its limitations and hopes, as well as the future research trends.

The importance and pitfalls of correlational science in palliative care research.

PubMed

Klepstad, Pål; Kaasa, Stein

2012-12-01

Correlational science discovers associations between patient characteristics, symptoms and biomarkers. Correlational science using data from cross-sectional studies is the most frequently applied study design in palliative care research. The purpose of this review is to address the importance and potential pitfalls in correlational science. Associations observed in correlational science studies can be the basis for generating hypotheses that can be tested in experimental studies and are the basic data needed to develop classification systems that can predict patient outcomes. Major pitfalls in correlational science are that associations do not equate with causality and that statistical significance does not necessarily equal a correlation that is of clinical interest. Researchers should be aware of the end-points that are clinically relevant, that end-points should be defined before the start of the analyses, and that studies with several end-points should account for multiplicity. Correlational science in palliative care research can identify related clinical factors and biomarkers. Interpretation of identified associations should be done with careful consideration of the limitations underlying correlational analyses.

Enhancing Evidence-Based Public Health Policy: Developing and Using Policy Narratives.

PubMed

Troy, Lisa M; Kietzman, Kathryn G

2016-06-01

Academic researchers and clinicians have a critical role in shaping public policies to improve the health of an aging America. Policy narratives that pair personal stories with research statistics are a powerful tool to share knowledge generated in academic and clinical settings with policymakers. Effective policy narratives rely on a trustworthy and competent narrator and a compelling story that highlights the personal impact of policies under consideration and academic research that bolsters the story. Awareness of the cultural differences in the motivations, expectations, and institutional constraints of academic researchers and clinicians as information producers and U.S. Congress and federal agencies as information users is critical to the development of policy narratives that impact policy decisions. The current article describes the development and use of policy narratives to bridge cultures and enhance evidence-based public health policies that better meet the needs of older adults. [Journal of Gerontological Nursing, 42(6), 11-17.]. Copyright 2016, SLACK Incorporated.

Evaluation on the Efficiency of Biomass Power Generation Industry in China

PubMed Central

Sun, Dong; Guo, Sen

2014-01-01

As a developing country with large population, China is facing the problems of energy resource shortage and growing environmental pollution arising from the coal-dominated energy structure. Biomass energy, as a kind of renewable energy with the characteristics of being easy to store and friendly to environment, has become the focus of China's energy development in the future. Affected by the advanced power generation technology and diversified geography environment, the biomass power generation projects show new features in recent years. Hence, it is necessary to evaluate the efficiency of biomass power generation industry by employing proper method with the consideration of new features. In this paper, the regional difference as a new feature of biomass power generation industry is taken into consideration, and the AR model is employed to modify the zero-weight issue when using data envelopment analysis (DEA) method to evaluate the efficiency of biomass power generation industry. 30 biomass power generation enterprises in China are selected as the sample, and the efficiency evaluation is performed. The result can provide some insights into the sustainable development of biomass power generation industry in China. PMID:25093209

Performance data for a terrestrial solar photovoltaic/water electrolysis experiment

NASA Technical Reports Server (NTRS)

Costogue, E. N.; Yasui, R. K.

1977-01-01

A description is presented of the equipment used in the experiment, taking into account the surplus solar panel from the Mariner 4 spacecraft which was used as a solar array source and an electrolytic hydrogen generator. Attention is also given to operational considerations and performance data, system considerations and aspects of optimization, and large-scale hydrogen production considerations.

Regulatory Approaches for Adding Capacity to Existing Hydropower Facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levine, Aaron L.; Curtis, Taylor L.; Kazerooni, Borna

In 2015, hydroelectric generation accounted for more than 6 percent of total net electricity generation in the United States and 46 percent of electricity generation from all renewables. The United States has considerable hydroelectric potential beyond what is already being developed. Nearly 7 GW of this potential is found by adding capacity to existing hydropower facilities. To optimize the value of hydroelectric generation, the U.S. Department of Energy's Hydropower Vision Study highlights the importance of adding capacity to existing facilities. This report provides strategic approaches and considerations for Federal Energy Regulatory Commission licensed and exempt hydropower facilities seeking to increasemore » generation capacity, which may include increases from efficiency upgrades. The regulatory approaches reviewed for this report include capacity and non-capacity amendments, adding capacity during relicensing, and adding capacity when converting a license to a 10-MW exemption.« less

Quantifying and Understanding Effects from Wildlife, Radar, and Public Engagement on Future Wind Deployment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tegen, Suzanne

This presentation provides an overview of findings from a report published in 2016 by researchers at the National Renewable Energy Laboratory, An Initial Evaluation of Siting Considerations on Current and Future Wind Deployment. The presentation covers the background for research, the Energy Department's Wind Vision, research methods, siting considerations, the wind project deployment process, and costs associated with siting considerations.

A Study Using a Monte Carlo Method of the Optimal Configuration of a Distribution Network in Terms of Power Loss Sensing

PubMed Central

Moon, Hyun Ho; Lee, Jong Joo; Choi, Sang Yule; Cha, Jae Sang; Kang, Jang Mook; Kim, Jong Tae; Shin, Myong Chul

2011-01-01

Recently there have been many studies of power systems with a focus on “New and Renewable Energy” as part of “New Growth Engine Industry” promoted by the Korean government. “New And Renewable Energy”—especially focused on wind energy, solar energy and fuel cells that will replace conventional fossil fuels—is a part of the Power-IT Sector which is the basis of the SmartGrid. A SmartGrid is a form of highly-efficient intelligent electricity network that allows interactivity (two-way communications) between suppliers and consumers by utilizing information technology in electricity production, transmission, distribution and consumption. The New and Renewable Energy Program has been driven with a goal to develop and spread through intensive studies, by public or private institutions, new and renewable energy which, unlike conventional systems, have been operated through connections with various kinds of distributed power generation systems. Considerable research on smart grids has been pursued in the United States and Europe. In the United States, a variety of research activities on the smart power grid have been conducted within EPRI’s IntelliGrid research program. The European Union (EU), which represents Europe’s Smart Grid policy, has focused on an expansion of distributed generation (decentralized generation) and power trade between countries with improved environmental protection. Thus, there is current emphasis on a need for studies that assesses the economic efficiency of such distributed generation systems. In this paper, based on the cost of distributed power generation capacity, calculations of the best profits obtainable were made by a Monte Carlo simulation. Monte Carlo simulations that rely on repeated random sampling to compute their results take into account the cost of electricity production, daily loads and the cost of sales and generate a result faster than mathematical computations. In addition, we have suggested the optimal design, which considers the distribution loss associated with power distribution systems focus on sensing aspect and distributed power generation. PMID:22164047

Research progress from the SCI Model Systems (SCIMS): An interactive discussion on future directions.

PubMed

Boninger, Michael L; Field-Fote, Edelle C; Kirshblum, Steven C; Lammertse, Daniel P; Dyson-Hudson, Trevor A; Hudson, Lesley; Heinemann, Allen W

2018-03-01

To describe current and future directions in spinal cord injury (SCI) research. The SCI Model Systems (SCIMS) programs funded by the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) during the 2011 to 2016 cycle provided abstracts describing findings from current research projects. Discussion among session participants generated ideas for research opportunities. Pre-conference workshop before the 2016 American Spinal Injury Association (ASIA) annual meeting. A steering committee selected by the SCIMS directors that included the moderators of the sessions at the ASIA pre-conference workshop, researchers presenting abstracts during the session, and the audience of over 100 attending participants in the pre-conference workshop. Group discussion followed presentations in 5 thematic areas of (1) Demographics and Measurement; (2) Functional Training; (3) Psychosocial Considerations; (4) Assistive Technology; and (5) Secondary Conditions. The steering committee reviewed and summarized discussion points on future directions for research and made recommendations for research based on the discussion in each of the five areas. Significant areas in need of research in SCI remain, the goal of which is continued improvement in the quality of life of individuals with SCI.

HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.

PubMed

Khomtchouk, Bohdan B; Van Booven, Derek J; Wahlestedt, Claes

2014-01-01

The graphical visualization of gene expression data using heatmaps has become an integral component of modern-day medical research. Heatmaps are used extensively to plot quantitative differences in gene expression levels, such as those measured with RNAseq and microarray experiments, to provide qualitative large-scale views of the transcriptonomic landscape. Creating high-quality heatmaps is a computationally intensive task, often requiring considerable programming experience, particularly for customizing features to a specific dataset at hand. Software to create publication-quality heatmaps is developed with the R programming language, C++ programming language, and OpenGL application programming interface (API) to create industry-grade high performance graphics. We create a graphical user interface (GUI) software package called HeatmapGenerator for Windows OS and Mac OS X as an intuitive, user-friendly alternative to researchers with minimal prior coding experience to allow them to create publication-quality heatmaps using R graphics without sacrificing their desired level of customization. The simplicity of HeatmapGenerator is that it only requires the user to upload a preformatted input file and download the publicly available R software language, among a few other operating system-specific requirements. Advanced features such as color, text labels, scaling, legend construction, and even database storage can be easily customized with no prior programming knowledge. We provide an intuitive and user-friendly software package, HeatmapGenerator, to create high-quality, customizable heatmaps generated using the high-resolution color graphics capabilities of R. The software is available for Microsoft Windows and Apple Mac OS X. HeatmapGenerator is released under the GNU General Public License and publicly available at: http://sourceforge.net/projects/heatmapgenerator/. The Mac OS X direct download is available at: http://sourceforge.net/projects/heatmapgenerator/files/HeatmapGenerator_MAC_OSX.tar.gz/download. The Windows OS direct download is available at: http://sourceforge.net/projects/heatmapgenerator/files/HeatmapGenerator_WINDOWS.zip/download.

Safety concerns and hidden agenda behind HPV vaccines: another generation of drug-dependent society?

PubMed

Khatami, Mahin

2016-12-01

Analyses of data and hidden agenda behind repeated failed outcomes of cancer research and therapy, status of American health, safety concerns for HPV vaccines and future research considerations are summarized in this commentary. A closer look at cancer science reveals that highly power structure (system) in medical establishment vs. anti-system and chaos in cancer research ('medical/scientific ponzi schemes') is potent recipe for failed therapeutics that kills patients but generates huge corporate profit. American health status ranks last among other developed nations despite the highest amount that USA invests in healthcare. This is a wake-up call to make sure that the evil part of human being does not prevent the health services that the public deserves. Otherwise, 'it does not matter how many resources you have, if you don't know, or don't want to know, how to use them, they will never be enough'. Answer to cancer and improved public health is possible only by switching the current corruptive and abusive culture of 'who you know' to a culture of 'what you know'. Policy makers and professionals in decision making roles are urged to return to common sense and logics that our Forefathers used to serve the public.

Uncovering the wisdom hidden between the lines: the Collaborative Reflexive Deliberative Approach.

PubMed

Crabtree, Benjamin F; Miller, William L; Gunn, Jane M; Hogg, William E; Scott, Cathie M; Levesque, Jean-Frederic; Harris, Mark F; Chase, Sabrina M; Advocat, Jenny R; Halma, Lisa M; Russell, Grant M

2018-05-23

Meta-analysis and meta-synthesis have been developed to synthesize results across published studies; however, they are still largely grounded in what is already published, missing the tacit 'between the lines' knowledge generated during many research projects that are not intrinsic to the main objectives of studies. To develop a novel approach to expand and deepen meta-syntheses using researchers' experience, tacit knowledge and relevant unpublished materials. We established new collaborations among primary health care researchers from different contexts based on common interests in reforming primary care service delivery and a diversity of perspectives. Over 2 years, the team met face-to-face and via tele- and video-conferences to employ the Collaborative Reflexive Deliberative Approach (CRDA) to discuss and reflect on published and unpublished results from participants' studies to identify new patterns and insights. CRDA focuses on uncovering critical insights, interpretations hidden within multiple research contexts. For the process to work, careful attention must be paid to ensure sufficient diversity among participants while also having people who are able to collaborate effectively. Ensuring there are enough studies for contextual variation also matters. It is necessary to balance rigorous facilitation techniques with the creation of safe space for diverse contributions. The CRDA requires large commitments of investigator time, the expense of convening facilitated retreats, considerable coordination, and strong leadership. The process creates an environment where interactions among diverse participants can illuminate hidden information within the contexts of studies, effectively enhancing theory development and generating new research questions and strategies.

Designing for knowledge: bridging socio-hydrological monitoring and beyond

NASA Astrophysics Data System (ADS)

Mao, F.; Clark, J.; Buytaert, W.; Ochoa-Tocachi, B. F.; Hannah, D. M.

2016-12-01

Many methods and applications have been developed to research socio-hydrological systems, such as participatory monitoring, environmental big data processing and sensor network data transmission. However, these data-centred activities are insufficient to guarantee successful knowledge co-generation, decision making or governance. This research suggests a shift of attentions in designing socio-hydrological monitoring tools, from designing for data to designing for knowledge (DfK). Compared to the former strategy, DfK has at least three features as follows. (1) Why monitor? DfK demands the data produced by the newly introduced monitoring application to have potentials to generate socio-hydrological knowledge that supports decision making or management. It means that when designing a monitoring tool, we should not only answer how to collect data, but also questions such as how to best use the collected data in the form of knowledge. (2) What is the role of monitoring? DfK admits that the socio-hydrological data and knowledge generated by monitoring is just one of many kinds to support decision making and management. It means that the importance of monitoring and scientific evidence should not be overestimated, and knowledge cogeneration and synthesis should be considered in advance in the monitoring design process. (3) Who participate? DfK implies a wider engagement of stakeholders, which is not restricted between volunteers as data collectors and providers, and scientist and researcher communities as main data users. It requires a broader consideration of users, including not only data collectors, processors and interpreters, but also local and indigenous knowledge providers, and decision makers who use the knowledge and data. In summary, this research proposes a knowledge-centred strategy in designing participatory socio-hydrological monitoring tools, in order to make monitoring more useful and effective.

The Changing Conduct of Geoscience in a Data Intensive World (Ian McHarg Medal Lecture)

NASA Astrophysics Data System (ADS)

Fox, P.

2012-04-01

Electronic facilitation of scientific research (often called eResearch or eScience) is increasingly prevelant in geosciences. Among the consequences of new and diversifying means of complex (*) data generation is that as many branches of science have become data-intensive (so-called fourth paradigm), they in turn broaden their long-tail distributions - smaller volume, but often complex data, will always lead to excellent science. There are many familar informatics functions that enable the conduct of science (by specialists or non-specialists) in this new regime. For example, the need for any user to be able to discover relations among and between the results of data analyses and informational queries. Unfortunately, true science exploration, for example visual discovery, over complex data remains more of an art form than an easily conducted practice. In general, the resource costs of creating useful visualizations has been increasing. Less than 10 years ago, it was assessed that data-centric science required a rough split between the time to generate, analyze, and publish data and the science based on that data. Today however, the visualization and analysis component has become a bottleneck, requiring considerably more of the overall effort and this trend will continue. Potentially even worse, is the choice to simplify analyses to 'get the work out'. Extra effort to make data understandable, something that should be routine, is now consuming considerable resources that could be used for many other purposes. It is now time to change that trend. This contribution lays out informatics paths for truly 'exploratory' conduct of science cast in the present and rapidly changing reality of Web/Internet-based data and software infrastructures. A logical consequence of these paths is that the people working in this new mode of research, i.e. data scientists, require additional and different education to become effective and routine users of new informatics capabilities. One goal is to achieve the same fluency that researchers may have in lab techniques, instrument utilization, model development and use, etc. Thus, in conclusion, curriculum and skill requirements for data scientists will be presented and discussed. * complex/ intensive = large volume, multi-scale, multi-modal, multi-dimensional, multi-disciplinary, and heterogeneous structure.

Can Community and School-Based Supports Improve the Achievement of First-Generation Immigrant Children Attending High-Poverty Schools?

PubMed

Dearing, Eric; Walsh, Mary E; Sibley, Erin; Lee-St John, Terry; Foley, Claire; Raczek, Anastacia E

2016-05-01

Using a quasi-experimental design, the effects of a student support intervention were estimated for the math and reading achievement of first-generation immigrant children (n = 667, M = 11.05 years of age) attending high-poverty, urban elementary schools. The intervention was designed to help schools identify developmental strengths and barriers to learning and, in turn, connect children to community and school supports aligned with their strengths and needs. By exploiting within-school changes in the implementation of the intervention, the present study revealed statistically and practically significant treatment effects indicating improvements in math and reading achievement at the end of elementary school. In addition, the intervention appears to considerably narrow achievement gaps between English language learners and immigrant children proficient in English. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

Recent Progress in Genome Editing Approaches for Inherited Cardiovascular Diseases.

PubMed

Kaur, Balpreet; Perea-Gil, Isaac; Karakikes, Ioannis

2018-06-02

This review describes the recent progress in nuclease-based therapeutic applications for inherited heart diseases in vitro, highlights the development of the most recent genome editing technologies and discusses the associated challenges for clinical translation. Inherited cardiovascular disorders are passed from generation to generation. Over the past decade, considerable progress has been made in understanding the genetic basis of inherited heart diseases. The timely emergence of genome editing technologies using engineered programmable nucleases has revolutionized the basic research of inherited cardiovascular diseases and holds great promise for the development of targeted therapies. The genome editing toolbox is rapidly expanding, and new tools have been recently added that significantly expand the capabilities of engineered nucleases. Newer classes of versatile engineered nucleases, such as the "base editors," have been recently developed, offering the potential for efficient and precise therapeutic manipulation of the human genome.

Graphene-Based Photocatalysts for Solar-Fuel Generation.

PubMed

Xiang, Quanjun; Cheng, Bei; Yu, Jiaguo

2015-09-21

The production of solar fuel through photocatalytic water splitting and CO2 reduction using photocatalysts has attracted considerable attention owing to the global energy shortage and growing environmental problems. During the past few years, many studies have demonstrated that graphene can markedly enhance the efficiency of photocatalysts for solar-fuel generation because of its unique 2D conjugated structure and electronic properties. Herein we summarize the recent advances in the application of graphene-based photocatalysts for solar-fuel production, including CO2 reduction to hydrocarbon fuel and water splitting to H2. A brief overview of the fundamental principles for splitting of water and reduction of CO2 is given. The different roles of graphene in these graphene-based photocatalysts for improving photocatalytic performance are discussed. Finally, the perspectives on the challenges and opportunities for future research in this promising area are also presented. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Generation of the first Autosomal Dominant Osteopetrosis Type II (ADO2) disease models

PubMed Central

Alam, Imranul; Gray, Amie K.; Chu, Kang; Ichikawa, Shoji; Mohammad, Khalid S.; Capannolo, Marta; Capulli, Mattia; Maurizi, Antonio; Muraca, Maurizio; Teti, Anna; Econs, Michael J.; Fattore, Andrea Del

2013-01-01

Autosomal Dominant Osteopetrosis Type II (ADO2) is a heritable osteosclerotic disorder dependent on osteoclast impairment. In most patients it results from heterozygous missense mutations in the chloride channel 7 (CLCN7) gene, encoding for a 2Cl−/1H+ antiporter. By a knock-in strategy inserting a missense mutation in the Clcn7 gene, our two research groups independently generated mouse models of ADO2 on different genetic backgrounds carrying the homolog of the most frequent heterozygous mutation (p.G213R) in the Clcn7 gene found in humans. Our results demonstrate that the heterozygous model holds true presenting with higher bone mass, increased numbers of poorly resorbing osteoclasts and a lethal phenotype in the homozygous state. Considerable variability is observed in the heterozygous mice according with the mouse background, suggesting that modifier genes could influence the penetrance of the disease gene. PMID:24185277

Data-driven modeling of solar-powered urban microgrids

PubMed Central

Halu, Arda; Scala, Antonio; Khiyami, Abdulaziz; González, Marta C.

2016-01-01

Distributed generation takes center stage in today’s rapidly changing energy landscape. Particularly, locally matching demand and generation in the form of microgrids is becoming a promising alternative to the central distribution paradigm. Infrastructure networks have long been a major focus of complex networks research with their spatial considerations. We present a systemic study of solar-powered microgrids in the urban context, obeying real hourly consumption patterns and spatial constraints of the city. We propose a microgrid model and study its citywide implementation, identifying the self-sufficiency and temporal properties of microgrids. Using a simple optimization scheme, we find microgrid configurations that result in increased resilience under cost constraints. We characterize load-related failures solving power flows in the networks, and we show the robustness behavior of urban microgrids with respect to optimization using percolation methods. Our findings hint at the existence of an optimal balance between cost and robustness in urban microgrids. PMID:26824071

Greider geothermal statement, based on testimony presented to Lt. Gov. Dymally Committee. [Development of geothermal industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greider, B.

Factors that contribute to the delay of geothermal development by utilities are discussed. These include: the increasingly complex regulations on the Geysers field; low quality and sizes of hot water resources; economics of financing geothermal exploration; professional experience; and lack of faith in the technology of conversion of hot water into electricity. Key issues that must be resolved before geothermal development can significantly penetrate the electricity generation industry are presented. It is pointed out that legislation to stimulate development of California's geothermal resources should be based on consideration of the following items: streamlined controls which allow geothermal exploration and developmentmore » to proceed under a minimum of effective regulation; reasonable tax provisions encouraging exploration, research, development, and production of geothermal energy; and suitable economic incentives for utility companies that will encourage early commitment to construct generating plants. (LBS)« less

Data-driven modeling of solar-powered urban microgrids.

PubMed

Halu, Arda; Scala, Antonio; Khiyami, Abdulaziz; González, Marta C

2016-01-01

Distributed generation takes center stage in today's rapidly changing energy landscape. Particularly, locally matching demand and generation in the form of microgrids is becoming a promising alternative to the central distribution paradigm. Infrastructure networks have long been a major focus of complex networks research with their spatial considerations. We present a systemic study of solar-powered microgrids in the urban context, obeying real hourly consumption patterns and spatial constraints of the city. We propose a microgrid model and study its citywide implementation, identifying the self-sufficiency and temporal properties of microgrids. Using a simple optimization scheme, we find microgrid configurations that result in increased resilience under cost constraints. We characterize load-related failures solving power flows in the networks, and we show the robustness behavior of urban microgrids with respect to optimization using percolation methods. Our findings hint at the existence of an optimal balance between cost and robustness in urban microgrids.

Environmental-Economic Assessment Of Generation, Flow And Efficiency Of Use Of Production And Consumption Waste

NASA Astrophysics Data System (ADS)

Mikhailov, V. G.; Golofastova, N. N.; Galanina, T. V.; Koroleva, T. G.; Mikhailova, Ya S.

2017-01-01

The article deals with the issues of environmental and economic analysis of industrial and economic activities of an enterprise to assess the generation, flow and efficiency of production and consumption waste. The purpose of research is the analysis and the development of theoretical propositions for the functioning of the system of environmental and economic indicators for the effective management of production and consumption waste in the enterprise. The analysis of the existing systems of environmental and economic indicators taking into consideration the industry characteristics and the types of negative impacts is carried out. The main result of the study is the development of the system of environmental and economic indicators of production and consumption waste, adapted to the modern requirements. The results of the study can be recommended to support the effective management decision-making concerning waste management and the establishment of appropriate infrastructure.

REVIEWS OF TOPICAL PROBLEMS: The nature of neutrino mass and the phenomenon of neutrino oscillations

NASA Astrophysics Data System (ADS)

Gershtein, Semen S.; Kuznetsov, E. P.; Ryabov, Vladimir A.

1997-08-01

Various aspects of the neutrino mass problem are discussed in the light of existing model predictions and extensive experimental data. Generation mechanisms are considered and possible gauge-theory neutrino mass hierarchies, in particular the most popular 'flipped see-saw' models, are discussed. Based on the currently available astrophysical data on the integral density of matter in the Universe and on the spectral anisotropy of the relic cosmic radiation, the cosmological implications of a non-zero neutrino mass are described in detail. Results from various mass-measuring methods are presented. Considerable attention is given to heavy neutrino oscillations. Oscillation mechanisms both in vacuum and in matter are considered in detail. Experiments on oscillations at low and high energies and new generation large-flight-base facilities are described. The present state of research into oscillations of solar and atmospheric neutrinos is reviewed.

Disciplining Bioethics: Towards a Standard of Methodological Rigor in Bioethics Research

PubMed Central

Adler, Daniel; Shaul, Randi Zlotnik

2012-01-01

Contemporary bioethics research is often described as multi- or interdisciplinary. Disciplines are characterized, in part, by their methods. Thus, when bioethics research draws on a variety of methods, it crosses disciplinary boundaries. Yet each discipline has its own standard of rigor—so when multiple disciplinary perspectives are considered, what constitutes rigor? This question has received inadequate attention, as there is considerable disagreement regarding the disciplinary status of bioethics. This disagreement has presented five challenges to bioethics research. Addressing them requires consideration of the main types of cross-disciplinary research, and consideration of proposals aiming to ensure rigor in bioethics research. PMID:22686634

The extent of food waste generation across EU-27: different calculation methods and the reliability of their results.

PubMed

Bräutigam, Klaus-Rainer; Jörissen, Juliane; Priefer, Carmen

2014-08-01

The reduction of food waste is seen as an important societal issue with considerable ethical, ecological and economic implications. The European Commission aims at cutting down food waste to one-half by 2020. However, implementing effective prevention measures requires knowledge of the reasons and the scale of food waste generation along the food supply chain. The available data basis for Europe is very heterogeneous and doubts about its reliability are legitimate. This mini-review gives an overview of available data on food waste generation in EU-27 and discusses their reliability against the results of own model calculations. These calculations are based on a methodology developed on behalf of the Food and Agriculture Organization of the United Nations and provide data on food waste generation for each of the EU-27 member states, broken down to the individual stages of the food chain and differentiated by product groups. The analysis shows that the results differ significantly, depending on the data sources chosen and the assumptions made. Further research is much needed in order to improve the data stock, which builds the basis for the monitoring and management of food waste. © The Author(s) 2014.

Wind turbines using self-excited three-phase induction generators: an innovative solution for voltage-frequency control

NASA Astrophysics Data System (ADS)

Brudny, J. F.; Pusca, R.; Roisse, H.

2008-08-01

A considerable number of communities throughout the world, most of them isolated, need hybrid energy solutions either for rural electrification or for the reduction of diesel use. Despite several research projects and demonstrations which have been conducted in recent years, wind-diesel technology remains complex and much too costly. Induction generators are the most robust and common for wind energy systems but this option is a serious challenge for electrical regulation. When a wind turbine is used in an off-grid configuration, either continuously or intermittently, precise and robust regulation is difficult to attain. The voltage parameter regulation option, as was experienced at several remote sites (on islands and in the arctic for example), is a safe, reliable and relatively simple technology, but does not optimize the wave quality and creates instabilities. These difficulties are due to the fact that no theory is available to describe the system, due to the inverse nature of the problem. In order to address and solve the problem of the unstable operation of this wind turbine generator, an innovative approach is described, based on a different induction generator single phase equivalent circuit.

Holodeck: Telepresence Dome Visualization System Simulations

NASA Technical Reports Server (NTRS)

Hite, Nicolas

2012-01-01

This paper explores the simulation and consideration of different image-projection strategies for the Holodeck, a dome that will be used for highly immersive telepresence operations in future endeavors of the National Aeronautics and Space Administration (NASA). Its visualization system will include a full 360 degree projection onto the dome's interior walls in order to display video streams from both simulations and recorded video. Because humans innately trust their vision to precisely report their surroundings, the Holodeck's visualization system is crucial to its realism. This system will be rigged with an integrated hardware and software infrastructure-namely, a system of projectors that will relay with a Graphics Processing Unit (GPU) and computer to both project images onto the dome and correct warping in those projections in real-time. Using both Computer-Aided Design (CAD) and ray-tracing software, virtual models of various dome/projector geometries were created and simulated via tracking and analysis of virtual light sources, leading to the selection of two possible configurations for installation. Research into image warping and the generation of dome-ready video content was also conducted, including generation of fisheye images, distortion correction, and the generation of a reliable content-generation pipeline.

The dynamic and steady state behavior of a PEM fuel cell as an electric energy source

NASA Astrophysics Data System (ADS)

Costa, R. A.; Camacho, J. R.

The main objective of this work is to extract information on the internal behavior of three small polymer electrolyte membrane fuel cells under static and dynamic load conditions. A computational model was developed using Scilab [SCILAB 4, Scilab-a free scientific software package, http://www.scilab.org/, INRIA, France, December, 2005] to simulate the static and dynamic performance [J.M. Correa, A.F. Farret, L.N. Canha, An analysis of the dynamic performance of proton exchange membrane fuel cells using an electrochemical model, in: 27th Annual Conference of IEEE Industrial Electronics Society, 2001, pp. 141-146] of this particular type of fuel cell. This dynamic model is based on electrochemical equations and takes into consideration most of the chemical and physical characteristics of the device in order to generate electric power. The model takes into consideration the operating, design parameters and physical material properties. The results show the internal losses and concentration effects behavior, which are of interest for power engineers and researchers.

The prospect for international regulatory interventions in embryo transfer and reproductive technologies in the next century.

PubMed

Evans, B R

1999-01-01

Historically, international regulatory interventions in the area of animal reproductive technologies have focused on the need for mitigation against the dissemination of diseases with the movement of genetics and germplasm across international borders. The continued globalization of agriculture under the Sanitary/Phytosanitary (SPS) Agreement of the World Trade Organization (WTO) ensures that disease considerations arising from third and fourth generation reproductive technologies such as in vitro fertilized embryos, transgenics and xenotransplantation will continue to give rise to animal health regulatory measures. Furthermore, in the aftermath of the raising of the public consciousness and the ensuing consumer confidence crisis concerning animal husbandry and livestock production practices following the Bovine Spongiform Encephalopathy outbreak, evolving societal values are expected to expand regulatory considerations to address veterinary public health and ethical concerns. Consequently, it is expected that the role of the International Embryo Transfer Society in fostering meaningful dialogue and profiling of the research necessary to provide for appropriate science based regulation development will increase in importance.

Lunar Base Sitting

NASA Astrophysics Data System (ADS)

Staehle, Robert L.; Burke, James D.; Snyder, Gerald C.; Dowling, Richard; Spudis, Paul D.

1993-12-01

Speculation with regard to a permanent lunar base has been with us since Robert Goddard was working on the first liquid-fueled rockets in the 1920's. With the infusion of data from the Apollo Moon flights, a once speculative area of space exploration has become an exciting possibility. A Moon base is not only a very real possibility, but is probably a critical element in the continuation of our piloted space program. This article, originally drafted by World Space Foundation volunteers in conjuction with various academic and research groups, examines some of the strategies involved in selecting an appropriate site for such a lunar base. Site selection involves a number of complex variables, including raw materials for possible rocket propellant generation, hot an cold cycles, view of the sky (for astronomical considerations, among others), geological makeup of the region, and more. This article summarizes the key base siting considerations and suggests some alternatives. Availability of specific resources, including energy and certain minerals, is critical to success.

Older Asian Indians resettled in America: narratives about households, culture and generation.

PubMed

Kalavar, Jyotsna M; Van Willigen, John

2005-09-01

Immigration in late life can be a complex experience. Older adults who have spent a considerable part of their life in one cultural milieu face several challenges in adapting to a new societal framework. Demographically speaking, the numbers of immigrants of Asian Indian origin continue to rise phenomenally in the United States. In this project, the experience of Asian Indian elderly immigrants to the United States was recorded through home visits and personal interviews. Parents of adult immigrants often choose to immigrate late in life primarily for purposes of family reunification. Providing assistance with raising grandchildren was also an important consideration. This article explores various aspects that surfaced from the analysis of interviews; these include personal investment in adult children, language/cultural barriers, use of formal services, acculturative experience, aging in India, intergenerational relationships, and expectations for the future. The findings highlight the need for gerontological research that is culturally attuned to the needs of these elders so service delivery may be optimally provided.

Design Considerations for Developing Biodegradable Magnesium Implants

NASA Astrophysics Data System (ADS)

Brar, Harpreet S.; Keselowsky, Benjamin G.; Sarntinoranont, Malisa; Manuel, Michele V.

The integration of biodegradable and bioabsorbable magnesium implants into the human body is a complex undertaking that faces major challenges. The complexity arises from the fact that biomaterials must meet both engineering and physiological requirements to ensure the desired properties. Historically, efforts have been focused on the behavior of commercial magnesium alloys in biological environments and their resultant effect on cell-mediated processes. Developing causal relationships between alloy chemistry and micro structure, and its effect on cellular behavior can be a difficult and time intensive process. A systems design approach driven by thermodynamics has the power to provide significant contributions in developing the next generation of magnesium alloy implants with controlled degradability, biocompatibility, and optimized mechanical properties, at reduced time and cost. This approach couples experimental research with theory and mechanistic modeling for the accelerated development of materials. The aim of this article is to enumerate this strategy, design considerations and hurdles for developing new magnesium alloys for use as biodegradable implant materials [1].

Lunar Base Sitting

NASA Technical Reports Server (NTRS)

Staehle, Robert L.; Burke, James D.; Snyder, Gerald C.; Dowling, Richard; Spudis, Paul D.

1993-01-01

Speculation with regard to a permanent lunar base has been with us since Robert Goddard was working on the first liquid-fueled rockets in the 1920's. With the infusion of data from the Apollo Moon flights, a once speculative area of space exploration has become an exciting possibility. A Moon base is not only a very real possibility, but is probably a critical element in the continuation of our piloted space program. This article, originally drafted by World Space Foundation volunteers in conjuction with various academic and research groups, examines some of the strategies involved in selecting an appropriate site for such a lunar base. Site selection involves a number of complex variables, including raw materials for possible rocket propellant generation, hot an cold cycles, view of the sky (for astronomical considerations, among others), geological makeup of the region, and more. This article summarizes the key base siting considerations and suggests some alternatives. Availability of specific resources, including energy and certain minerals, is critical to success.

Practical considerations in the development of hemoglobin-based oxygen therapeutics.

PubMed

Kim, Hae Won; Estep, Timothy N

2012-09-01

The development of hemoglobin based oxygen therapeutics (HBOCs) requires consideration of a number of factors. While the enabling technology derives from fundamental research on protein biochemistry and biological interactions, translation of these research insights into usable medical therapeutics demands the application of considerable technical expertise and consideration and reconciliation of a myriad of manufacturing, medical, and regulatory requirements. The HBOC development challenge is further exacerbated by the extremely high intravenous doses required for many of the indications contemplated for these products, which in turn implies an extremely high level of purity is required. This communication discusses several of the important product configuration and developmental considerations that impact the translation of fundamental research discoveries on HBOCs into usable medical therapeutics.

Facility Design Considerations.

ERIC Educational Resources Information Center

Chase, William W.

1967-01-01

Increasing need for vocational education under the impetus of federal aid is generating a demand for vocational teaching facilities. Factors to be considered in planning these facilities inclued--(1) site development, (2) program needs, (3) administrative considerations, (4) environmental controls. (5) mechanical systems, and (6) area and space…

The clinical investigator-subject relationship: a contextual approach

PubMed Central

2009-01-01

Background The nature of the relationship between a clinical investigator and a research subject has generated considerable debate because the investigator occupies two distinct roles: clinician and scientist. As a clinician, the investigator has duties to provide the patient with optimal care and undivided loyalty. As a scientist, the investigator has duties to follow the rules, procedures and methods described in the protocol. Results and conclusion In this article, I present a contextual approach to the investigator-subject relationship. The extent of the investigator's duty to provide the patient/subject with clinical care can vary from one situation to the next, as a function of several factors, including: the research design, benefits and risks of the research; the subject's reasonable expectations, motivations, and vulnerabilities; the investigator's ability to benefit the subject; and the investigator's prior relationship with the subject. These and other factors need to be considered when determining the clinical investigator's obligations to provide clinical care to human research subjects. In some research contexts, the investigator has extensive clinical obligations to the patient/subject; in others, the investigator has minimal ones. PMID:19958542

Students as subjects in food advertising studies. An appraisal of appropriateness.

PubMed

Choi, Hojoon; Reid, Leonard N

2014-10-01

Considerable knowledge on food advertising has been generated by research on consumers' psychological reactions to food advertising messaging using either students or nonstudents as subjects. Building on past research, this article investigates the methodological question of whether students are appropriate surrogates for nonstudents in food advertising studies. Following exposure to print advertisements featuring healthy and unhealthy foods with two different nutrient attribute-based message appeals, student and nonstudent subjects were asked to complete five standard evaluative response measures to the food ads: claim believability, attitude-toward-the ad, attitude-toward-the-product, attitude-toward-the-brand, and purchase intention. Among the findings, students were found to react differently and more negatively to identical food advertisements than nonstudents. Overall, the message sent to health communication researchers, policy officials, and practicing professionals is - unless certain criteria are satisfied - students should be considered inadequate subjects to represent all age groups of the general population in food advertising research. Thus, conclusions drawn from student-based research about advertising processing and effects should be questioned and broad generalizations avoided. Copyright © 2014 Elsevier Ltd. All rights reserved.

Experiment for Integrating Dutch 3d Spatial Planning and Bim for Checking Building Permits

NASA Astrophysics Data System (ADS)

van Berlo, L.; Dijkmans, T.; Stoter, J.

2013-09-01

This paper presents a research project in The Netherlands in which several SMEs collaborated to create a 3D model of the National spatial planning information. This 2D information system described in the IMRO data standard holds implicit 3D information that can be used to generate an explicit 3D model. The project realized a proof of concept to generate a 3D spatial planning model. The team used the model to integrate it with several 3D Building Information Models (BIMs) described in the open data standard Industry Foundation Classes (IFC). Goal of the project was (1) to generate a 3D BIM model from spatial planning information to be used by the architect during the early design phase, and (2) allow 3D checking of building permits. The team used several technologies like CityGML, BIM clash detection and GeoBIM to explore the potential of this innovation. Within the project a showcase was created with a part of the spatial plan from the city of The Hague. Several BIM models were integrated in the 3D spatial plan of this area. A workflow has been described that demonstrates the benefits of collaboration between the spatial domain and the AEC industry in 3D. The research results in a showcase with conclusions and considerations for both national and international practice.

MO-E-BRC-03: Fast Online Replanning Techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, X.

Online adaptive radiation therapy has the potential to ensure delivery of optimal treatment to the patient by accounting for anatomical and potentially functional changes that occur from one fraction to the next and over the course of treatment. While on-line adaptive RT (ART) has been a topic of many publications, discussions, and research, it has until very recently remained largely a concept and not a practical implementation. However, recent advances in on-table imaging, use of deformable image registration for contour generation and dose tracking, faster and more efficient plan optimization, as well as fast quality assurance method has enabled themore » implementation of ART in the clinic in the past couple of years. The introduction of these tools into routine clinical use requires many considerations and progressive knowledge to understand how processes that have historically taken hours/days to complete can now be done in less than 30 minutes. This session will discuss considerations to perform real time contouring, planning and patient specific QA, as well as a practical workflow and the required resources. Learning Objectives: To understand the difficulties, challenges and available technologies for online adaptive RT. To understand how to implement online adaptive therapy in a clinical environment and to understand the workflow and resources required. To understand the limitations and sources of uncertainty in the online adaptive process I have research funding from ViewRay Inc. and Philips Medical Systems.; R. Kashani, I have research funding from ViewRay Inc. and Philips Medical Systems.; X. Li, Research supported by Elekta Inc.« less

A practical guide to epidemiological practice and standards in the identification and validation of diagnostic markers using a bladder cancer example.

PubMed

Behrens, T; Bonberg, N; Casjens, S; Pesch, B; Brüning, T

2014-01-01

Technical advances to analyze biological markers have generated a plethora of promising new marker candidates for early detection of cancer. However, in subsequent analyses only few could be successfully validated as being predictive, clinically useful, or effective. This failure is partially due to rapid publication of results that were detected in early stages of biomarker research. Methodological considerations are a major concern when carrying out molecular epidemiological studies of diagnostic markers to avoid errors that increase the potential for bias. Although guidelines for conducting studies and reporting of results have been published to improve the quality of marker studies, their planning and execution still need to be improved. We will discuss different sources of bias in study design, handling of specimens, and statistical analysis to illustrate possible pitfalls associated with marker research, and present legal, ethical, and technical considerations associated with storage and handling of specimens. This article presents a guide to epidemiological standards in marker research using bladder cancer as an example. Because of the possibility to detect early cancer stages due to leakage of molecular markers from the target organ or exfoliation of tumor cells into the urine, bladder cancer is particularly useful to study diagnostic markers. To improve the overall quality of marker research, future developments should focus on networks of studies and tissue banks according to uniform legal, ethical, methodological, and technical standards. This article is part of a Special Issue entitled: Computational Proteomics in the Post-Identification Era. Guest Editors: Martin Eisenacher and Christian Stephan. © 2013.

MO-E-BRC-02: MRI-Guided Online Adaptive Radiotherapy: The UCLA Approach to Quality Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lamb, J.

Online adaptive radiation therapy has the potential to ensure delivery of optimal treatment to the patient by accounting for anatomical and potentially functional changes that occur from one fraction to the next and over the course of treatment. While on-line adaptive RT (ART) has been a topic of many publications, discussions, and research, it has until very recently remained largely a concept and not a practical implementation. However, recent advances in on-table imaging, use of deformable image registration for contour generation and dose tracking, faster and more efficient plan optimization, as well as fast quality assurance method has enabled themore » implementation of ART in the clinic in the past couple of years. The introduction of these tools into routine clinical use requires many considerations and progressive knowledge to understand how processes that have historically taken hours/days to complete can now be done in less than 30 minutes. This session will discuss considerations to perform real time contouring, planning and patient specific QA, as well as a practical workflow and the required resources. Learning Objectives: To understand the difficulties, challenges and available technologies for online adaptive RT. To understand how to implement online adaptive therapy in a clinical environment and to understand the workflow and resources required. To understand the limitations and sources of uncertainty in the online adaptive process I have research funding from ViewRay Inc. and Philips Medical Systems.; R. Kashani, I have research funding from ViewRay Inc. and Philips Medical Systems.; X. Li, Research supported by Elekta Inc.« less

MO-E-BRC-01: Online Adaptive MR-Guided RT: Workflow and Clinical Implementation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kashani, R.

Online adaptive radiation therapy has the potential to ensure delivery of optimal treatment to the patient by accounting for anatomical and potentially functional changes that occur from one fraction to the next and over the course of treatment. While on-line adaptive RT (ART) has been a topic of many publications, discussions, and research, it has until very recently remained largely a concept and not a practical implementation. However, recent advances in on-table imaging, use of deformable image registration for contour generation and dose tracking, faster and more efficient plan optimization, as well as fast quality assurance method has enabled themore » implementation of ART in the clinic in the past couple of years. The introduction of these tools into routine clinical use requires many considerations and progressive knowledge to understand how processes that have historically taken hours/days to complete can now be done in less than 30 minutes. This session will discuss considerations to perform real time contouring, planning and patient specific QA, as well as a practical workflow and the required resources. Learning Objectives: To understand the difficulties, challenges and available technologies for online adaptive RT. To understand how to implement online adaptive therapy in a clinical environment and to understand the workflow and resources required. To understand the limitations and sources of uncertainty in the online adaptive process I have research funding from ViewRay Inc. and Philips Medical Systems.; R. Kashani, I have research funding from ViewRay Inc. and Philips Medical Systems.; X. Li, Research supported by Elekta Inc.« less

The effect of the NERC CIP standards on the reliability of the North American Bulk Electric System

DOE PAGES

Ladendorff, Marlene Z.

2016-06-01

Considerable money and effort has been expended by generation, transmission, and distribution entities in North America to implement the North American Electric Reliability Corporation (NERC) Critical Infrastructure Protection (CIP) standards for the bulk electric system. Assumptions have been made that as a result of the implementation of the standards, the grid is more cyber secure than it was pre-NERC CIP, but are there data supporting these claims, or only speculation? Has the implementation of the standards had an effect on the grid? Furthermore, developing a research study to address these and other questions provided surprising results.

Experimental design and quantitative analysis of microbial community multiomics.

PubMed

Mallick, Himel; Ma, Siyuan; Franzosa, Eric A; Vatanen, Tommi; Morgan, Xochitl C; Huttenhower, Curtis

2017-11-30

Studies of the microbiome have become increasingly sophisticated, and multiple sequence-based, molecular methods as well as culture-based methods exist for population-scale microbiome profiles. To link the resulting host and microbial data types to human health, several experimental design considerations, data analysis challenges, and statistical epidemiological approaches must be addressed. Here, we survey current best practices for experimental design in microbiome molecular epidemiology, including technologies for generating, analyzing, and integrating microbiome multiomics data. We highlight studies that have identified molecular bioactives that influence human health, and we suggest steps for scaling translational microbiome research to high-throughput target discovery across large populations.

Analysis of Lean Premixed/Prevaporized Combustion with KIVA-2

NASA Technical Reports Server (NTRS)

Deur, J. M.; Kundu, K. P.; Darling, D. D.; Cline, M. C.; Micklow, G. J.; Harper, M. R.; Simons, T. A.

1994-01-01

Requirements to reduce the emissions of pollutants from gas turbines used in aircraft propulsion and ground based power generation have led to consideration of lean premixed/prevaporized (LPP) combustion concept. This paper describes some of the LPP flame tube analyses performed at the NASA Research Center with KIVA-2, a well-known multi-dimensional CFD code for problems including sprays, turbulence, and combustion. Modifications to KIVA-2's boundary condition and chemistry treatments have been made to meet the needs of the present study. The study itself focuses on two key aspects of the LPP concept, low emissions and flame stability (including flashback and lean blowoff.

[Basic considerations during outsourcing of clinical data management services].

PubMed

Shen, Tong; Liu, Yan

2015-11-01

With worldwide improvements in the regulations of international and domestic clinical trial conductions, the quality of clinical trials and trial data management are receiving a great deal of attention. To ensure the quality of clinical trials, maintain business flexibilities and effectively utilize internal and external resources, the outsourcing model is used in the management of clinical data in operation of pharmaceutical companies. The essential criteria of a successful outsourcing mode in clinical trial are selection of qualified contract research organizations (CRO); establishment of appropriate outsourcing model, and generation of effective quality control systems to ensure the authenticity, integrity and accuracy of the clinical trial data.

Numerical Modeling of Pulse Detonation Rocket Engine Gasdynamics and Performance

NASA Technical Reports Server (NTRS)

Morris, C. I.

2003-01-01

Pulse detonation engines (PDB) have generated considerable research interest in recent years as a chemical propulsion system potentially offering improved performance and reduced complexity compared to conventional gas turbines and rocket engines. The detonative mode of combustion employed by these devices offers a theoretical thermodynamic advantage over the constant-pressure deflagrative combustion mode used in conventional engines. However, the unsteady blowdown process intrinsic to all pulse detonation devices has made realistic estimates of the actual propulsive performance of PDES problematic. The recent review article by Kailasanath highlights some of the progress that has been made in comparing the available experimental measurements with analytical and numerical models.

Submesoscale currents in the ocean

PubMed Central

2016-01-01

This article is a perspective on the recently discovered realm of submesoscale currents in the ocean. They are intermediate-scale flow structures in the form of density fronts and filaments, topographic wakes and persistent coherent vortices at the surface and throughout the interior. They are created from mesoscale eddies and strong currents, and they provide a dynamical conduit for energy transfer towards microscale dissipation and diapycnal mixing. Consideration is given to their generation mechanisms, instabilities, life cycles, disruption of approximately diagnostic force balance (e.g. geostrophy), turbulent cascades, internal-wave interactions, and transport and dispersion of materials. At a fundamental level, more questions remain than answers, implicating a programme for further research. PMID:27279778

Interior noise considerations for advanced high-speed turboprop aircraft

NASA Technical Reports Server (NTRS)

Mixson, J. S.; Farassat, F.; Leatherwood, J. D.; Prydz, R.; Revell, J. D.

1982-01-01

This paper describes recent research on noise generated by high-speed propellers, on noise transmission through acoustically treated aircraft sidewalls and on subjective response to simulated turboprop noise. Propeller noise discussion focuses on theoretical prediction methods for complex blade shapes designed for low noise at Mach = 0.8 flight and on comparisons with experimental test results. Noise transmission experiments using a 168 cm. diameter aircraft fuselage model and scaled heavy-double-wall treatments indicate that the treatments perform well and that the predictions are usually conservative. Studies of subjective comfort response in an anechoic environment are described for noise signatures having combinations of broadband and propeller-type tone components.

HOLOMEM, optical mass memory investigations, volume 1

NASA Technical Reports Server (NTRS)

Roberts, H. N.

1977-01-01

Research and design activities in support of the development of a 10 to the 12th power-bit holographic read/write optical mass memory (HOLOMEM) with some moving parts for space applications are summarized. The report consists of four sections: (1) a general introduction, which includes a summary of key accomplishments and the principal conclusions of the study; (2) a comprehensive analysis of alternative HOLOMEM system concepts; (3) a discussion of important design and tradeoff considerations related to the fabrication, test, and evaluation of a breadboard holographic recorder/reproducer; and (4) a summary of experimental data generated to define the holographic recording performance of two quasi-commercial photoplastic recording films.

Toward a social justice theory of demographic transition: lessons from India's Kerala State.

PubMed

Ratcliffe, J W

1983-06-01

Recent research evidence, which suggests that observed demographic trends and patterns are largely consequences of broad structural changes in society, has raised serious doubts about the validity of traditional demographic theory and the framework for action it has generated. This theoretical essay 1st recasts classical demographic transition theory in general systems terms in order to make it consistent with the evidence and to place the processes of fertility and mortality in a larger social context. The demographic transition experience of Kerala State, India is then recounted to provide a concrete example of the demographic response in society to structural reforms based primarily on equity considerations.

Looks and linguistics: Impression formation in online exchange marketplaces.

PubMed

Ciuchta, Michael P; O'Toole, Jay

2016-01-01

This study advances theories of impression formation by focusing on two factors that generate emotional responses: physical attractiveness and positive word use. Although considerable research on impression formation exists, most studies consider factors in isolation and neglect possible interactions. Our theory introduces competing mechanisms regarding possible interaction effects, and we empirically test them in an online marketplace. Results from the analysis of 729 loan requests from a leading online peer-to-peer lending market suggest that physical attractiveness and positive word use work together to influence the likelihood of acquiring resources and establish an important boundary condition to the general "beauty is good" effect.

Instrumentation for the detection and characterization of exoplanets.

PubMed

Pepe, Francesco; Ehrenreich, David; Meyer, Michael R

2014-09-18

In no other field of astrophysics has the impact of new instrumentation been as substantial as in the domain of exoplanets. Before 1995 our knowledge of exoplanets was mainly based on philosophical and theoretical considerations. The years that followed have been marked, instead, by surprising discoveries made possible by high-precision instruments. Over the past decade, the availability of new techniques has moved the focus of research from the detection to the characterization of exoplanets. Next-generation facilities will produce even more complementary data that will lead to a comprehensive view of exoplanet characteristics and, by comparison with theoretical models, to a better understanding of planet formation.

In vitro selection of shape-changing DNA nanostructures capable of binding-induced cargo release.

PubMed

Oh, Seung Soo; Plakos, Kory; Xiao, Yi; Eisenstein, Michael; Soh, H Tom

2013-11-26

Many biological systems employ allosteric regulatory mechanisms, which offer a powerful means of directly linking a specific binding event to a wide spectrum of molecular functionalities. There is considerable interest in generating synthetic allosteric regulators that can perform useful molecular functions for applications in diagnostics, imaging and targeted therapies, but generating such molecules through either rational design or directed evolution has proven exceptionally challenging. To address this need, we present an in vitro selection strategy for generating conformation-switching DNA nanostructures that selectively release a small-molecule payload in response to binding of a specific trigger molecule. As an exemplar, we have generated a DNA nanostructure that hybridizes with a separate 'cargo strand' containing an abasic site. This abasic site stably sequesters a fluorescent cargo molecule in an inactive state until the DNA nanostructure encounters an ATP trigger molecule. This ATP trigger causes the nanostructure to release the cargo strand, thereby liberating the fluorescent payload and generating a detectable fluorescent readout. Our DNA nanostructure is highly sensitive, with an EC50 of 30 μM, and highly specific, releasing its payload in response to ATP but not to other chemically similar nucleotide triphosphates. We believe that this selection approach could be generalized to generate synthetic nanostructures capable of selective and controlled release of other small-molecule cargos in response to a variety of triggers, for both research and clinical applications.

Using a Hybrid of Student-Sourced Data and Web-Based Data for an Undergraduate Earth System Science Course

NASA Astrophysics Data System (ADS)

Sinton, C.

2014-12-01

In an undergraduate Earth System Science (ESS) course, students learn about the processes in which material and energy move between the different earth spheres. It is critical that quantitative analysis be part of the class in order to have students understand rates and magnitudes of these processes. It is even better if the students generate the data and research questions. At Ithaca College, ESS is a requirement for all Environmental Science majors and is their introduction into earth science. The majority of the lab periods for the class are devoted to research-based exercises in which students are asked to generate research questions and working hypotheses prior to data gathering. Several exercises use a hybrid of student-generated data and information available from on-line sources such as NOAA and USGS. For example, student groups gather water data from four water bodies on the campus over the course of the semester (e.g., temperature, pH, turbidity, conductivity) while at the same time accessing NOAA climatic data from a nearby weather station. The advantages of this approach include student ownership (and responsibility) and rich, diverse datasets that can be used to answer a variety of questions. Disadvantages include the inability of the instructor to fully anticipate the results, which can make planning difficult. In addition, considerable time is required to have students wade through the data, make mistakes, and then correct the mistakes. Nevertheless, the overall approach results in a richer and more effective learning experience compared to lab exercises that use data sets provided by the instructor.

Mycorrhizal mediation of plant response to atmospheric change: Air quality concepts and research considerations.

PubMed

Shafer, S R; Schoeneberger, M M

1991-01-01

The term 'global climate change' encompasses many physical and chemical changes in the atmosphere that have been induced by anthropogenic pollutants. Increases in concentrations of CO2 and CH4 enhance the 'greenhouse effect' of the atmosphere and may contribute to changes in temperature and precipitation patterns at the earth's surface. Nitrogen oxides and SO2 are phytotoxic and also react with other pollutants to produce other phytotoxins in the troposphere such as O3 and acidic substances. However, release of chlorofluorocarbons into the atmosphere may cause depletion of stratospheric O3, increasing the transmittance of ultraviolet-B (UV-B) radiation to the earth's surface. Increased intensities of UV-B could affect plants and enhance photochemical reactions that generate some phytotoxic pollutants. The role of mycorrhizae in plant responses to such stresses has received little attention. Although plans for several research programs have acknowledged the importance of drought tolerance and soil fertility in plant responses to atmospheric stresses, mycorrhizae are rarely targeted to receive specific investigation. Most vascular land plants form mycorrhizae, so the role of mycorrhizae in mediating plant responses to atmospheric change may be an important consideration in predicting effects of atmospheric changes on plants in managed and natural ecosystems.

Potential of Micro Hydroelectric Generator Embedded at 30,000 PE Effluent Discharge of Sewerage Treatment Plant

NASA Astrophysics Data System (ADS)

Che Munaaim, M. A.; Razali, N.; Ayob, A.; Hamidin, N.; Othuman Mydin, M. A.

2018-03-01

A micro hydroelectric generator is an energy conversion approach to generate electricity from potential (motion) energy to an electrical energy. In this research, it is desired to be implemented by using a micro hydroelectric generator which is desired to be embedded at the continuous flow of effluent discharge point of domestic sewerage treatment plant (STP). This research evaluates the potential of electricity generation from micro hydroelectric generator attached to 30,000 PE sewerage treatment plant. The power output obtained from calculation of electrical power conversion is used to identify the possibility of this system and its ability to provide electrical energy, which can minimize the cost of electric bill especially for the pumping system. The overview of this system on the practical application with the consideration of payback period is summarized. The ultimate aim of the whole application is to have a self-ecosystem electrical power generated for the internal use of STP by using its own flowing water in supporting the sustainable engineering towards renewable energy and energy efficient approach. The results shows that the output power obtained is lower than expected output power (12 kW) and fall beyond of the range of a micro hydro power (5kW - 100kW) since it is only generating 1.58 kW energy by calculation. It is also observed that the estimated payback period is longer which i.e 7 years to recoup the return of investment. A range of head from 4.5 m and above for the case where the flow shall at least have maintained at 0.05 m3/s in the selected plant in order to achieved a feasible power output. In conclusion, wastewater treatment process involves the flowing water (potential energy) especially at the effluent discharge point of STP is possibly harvested for electricity generation by embedding the micro hydroelectric generator. However, the selection of STP needs to have minimum 4.5 meter head with 0.05 m3/s of continuously flowing water to make it feasible to harvest.

Exposure of research personnel to carbon dioxide during euthanasia procedures.

PubMed

Amparan, Ashlee A; Djoufack-Momo, Shelly M; Grunden, Beverly; Boivin, Gregory P-

2014-07-01

CO₂ is one of the most commonly used euthanasia agents for laboratory animals. Considerable research has gone into the effect of the agent on animals, but little has been done to examine potential human exposure during these procedures. In this study, we examine the CO₂ concentrations to which personnel are exposed while euthanizing rodents with CO₂. To examine the environmental levels of CO₂ generated during euthanasia, we examined several variables including flow rate, inclusion of a cage in the euthanasia chamber, inversion of the euthanasia chamber, chamber size, distance from the euthanasia chamber, and room size. Under all conditions, CO₂ concentrations in the room temporarily increased significantly to 600 to 4000 ppm. The results of this study show that, under several testing scenarios, occupational levels of CO₂ did not exceed governmentally mandated allowable exposure limits during routine rodent euthanasia procedures.

Computer-task testing of rhesus monkeys (Macaca mulatta) in the social milieu.

PubMed

Washburn, D A; Harper, S; Rumbaugh, D M

1994-07-01

Previous research has demonstrated that a behavior and performance testing paradigm, in which rhesus monkeys (Macaca mulatta) manipulate a joystick to respond to computer-generated stimuli, provides environmental enrichment and supports the psychological well-being of captive research animals. The present study was designed to determine whether computer-task activity would be affected by pair-housing animals that had previously been tested only in their single-animal home cages. No differences were observed in productivity or performance levels as a function of housing condition, even when the animals were required to "self-identify" prior to performing each trial. The data indicate that cognitive challenge and control are as preferred by the animals as social opportunities, and that, together with comfort/health considerations, each must be addressed for the assurance of psychological well-being.

A Strategy to Identify Critical Appraisal Criteria for Primary Mixed-Method Studies

PubMed Central

Sale, Joanna E. M.; Brazil, Kevin

2015-01-01

The practice of mixed-methods research has increased considerably over the last 10 years. While these studies have been criticized for violating quantitative and qualitative paradigmatic assumptions, the methodological quality of mixed-method studies has not been addressed. The purpose of this paper is to identify criteria to critically appraise the quality of mixed-method studies in the health literature. Criteria for critically appraising quantitative and qualitative studies were generated from a review of the literature. These criteria were organized according to a cross-paradigm framework. We recommend that these criteria be applied to a sample of mixed-method studies which are judged to be exemplary. With the consultation of critical appraisal experts and experienced qualitative, quantitative, and mixed-method researchers, further efforts are required to revise and prioritize the criteria according to importance. PMID:26526412

Reliability and cost/worth evaluation of generating systems utilizing wind and solar energy

NASA Astrophysics Data System (ADS)

Bagen

The utilization of renewable energy resources such as wind and solar energy for electric power supply has received considerable attention in recent years due to adverse environmental impacts and fuel cost escalation associated with conventional generation. At the present time, wind and/or solar energy sources are utilized to generate electric power in many applications. Wind and solar energy will become important sources for power generation in the future because of their environmental, social and economic benefits, together with public support and government incentives. The wind and sunlight are, however, unstable and variable energy sources, and behave far differently than conventional sources. Energy storage systems are, therefore, often required to smooth the fluctuating nature of the energy conversion system especially in small isolated applications. The research work presented in this thesis is focused on the development and application of reliability and economic benefits assessment associated with incorporating wind energy, solar energy and energy storage in power generating systems. A probabilistic approach using sequential Monte Carlo simulation was employed in this research and a number of analyses were conducted with regards to the adequacy and economic assessment of generation systems containing wind energy, solar energy and energy storage. The evaluation models and techniques incorporate risk index distributions and different operating strategies associated with diesel generation in small isolated systems. Deterministic and probabilistic techniques are combined in this thesis using a system well-being approach to provide useful adequacy indices for small isolated systems that include renewable energy and energy storage. The concepts presented and examples illustrated in this thesis will help power system planners and utility managers to assess the reliability and economic benefits of utilizing wind energy conversion systems, solar energy conversion systems and energy storage in electric power systems and provide useful input to the managerial decision process.

Quantifying the direct use value of Condor seamount

NASA Astrophysics Data System (ADS)

Ressurreição, Adriana; Giacomello, Eva

2013-12-01

Seamounts often satisfy numerous uses and interests. Multiple uses can generate multiple benefits but also conflicts and impacts, calling, therefore, for integrated and sustainable management. To assist in developing comprehensive management strategies, policymakers recognise the need to include measures of socioeconomic analysis alongside ecological data so that practical compromises can be made. This study assessed the direct output impact (DOI) of the relevant marine activities operating at Condor seamount (Azores, central northeast Atlantic) as proxies of the direct use values provided by the resource system. Results demonstrated that Condor seamount supported a wide range of uses yielding distinct economic outputs. Demersal fisheries, scientific research and shark diving were the top-three activities generating the highest revenues, while tuna fisheries, whale watching and scuba-diving had marginal economic significance. Results also indicated that the economic importance of non-extractive uses of Condor is considerable, highlighting the importance of these uses as alternative income-generating opportunities for local communities. It is hoped that quantifying the direct use values provided by Condor seamount will contribute to the decision making process towards its long-term conservation and sustainable use.

Quality versus quantity: The complexities of quality of life determinations for neonatal nurses.

PubMed

Green, Janet; Darbyshire, Philip; Adams, Anne; Jackson, Debra

2017-11-01

The ability to save the life of an extremely premature baby has increased substantially over the last decade. This survival, however, can be associated with unfavourable outcomes for both baby and family. Questions are now being asked about quality of life for survivors of extreme prematurity. Quality of life is rightly deemed to be an important consideration in high technology neonatal care; yet, it is notoriously difficult to determine or predict. How does one define and operationalise what is considered to be in the best interest of a surviving extremely premature baby, especially when the full extent of the outcomes might not be known for several years? The research investigates the caregiving dilemmas often faced by neonatal nurses when caring for extremely premature babies. This article explores the issues arising for neonatal nurses when they considered the philosophical and ethical questions about quality of life in babies ≤24 weeks gestation. Data were collected via a questionnaire to Australian neonatal nurses and semi-structured interviews with 24 neonatal nurses in New South Wales, Australia. Ethical considerations: Ethical processes and procedures have been adhered to by the researchers. A qualitative approach was used to analyse the data. The theme 'difficult choices' was generated which comprised three sub-themes: 'damaged through survival', 'the importance of the brain' and 'families are important'. The results show that neonatal nurses believed that quality of life was an important consideration; yet they experienced significant inner conflict and uncertainty when asked to define or suggest specific elements of quality of life, or to suggest how it might be determined. It was even more difficult for the nurses to say when an extremely premature baby's life possessed quality. Their previous clinical and personal experiences led the nurses to believe that the quality of the family's life was important, and possibly more so than the quality of life of the surviving baby. This finding contrasts markedly with much of the existing literature in this field. Quality of life for extremely premature babies was an important consideration for neonatal nurses; however, they experienced difficulty deciding how to operationalise such considerations in their everyday clinical practice.

Essential considerations in developing attention control groups in behavioral research.

PubMed

Aycock, Dawn M; Hayat, Matthew J; Helvig, Ashley; Dunbar, Sandra B; Clark, Patricia C

2018-06-01

Attention control groups strengthen randomized controlled trials of behavioral interventions, but researchers need to give careful consideration to the attention control activities. A comparative effectiveness research framework provides an ideal opportunity for an attention control group as a supplement to standard care, so participants potentially receive benefit regardless of group assignment. The anticipated benefit of the control condition must be independent of the study outcome. Resources needed for attention control activities need to be carefully considered and ethical considerations carefully weighed. In this paper we address nine considerations for the design and implementation of attention control groups: (1) ensure attention control activities are not associated with the outcome; (2) avoid contamination of the intervention or control group; (3) design comparable control and intervention activities; (4) ensure researcher training to adequately administer both treatment arms; (5) design control activities to be interesting and acceptable to participants; (6) evaluate attention control activities; (7) consider additional resources needed to implement attention control activities; (8) quantifying the effects of attention control and intervention groups; and (9) ethical considerations with attention control groups. Examples from the literature and ongoing research are presented. Careful planning for the attention control group is as important as for the intervention group. Researchers can use the considerations presented here to assist in planning for the best attention control group for their study. © 2018 Wiley Periodicals, Inc.

Computer science security research and human subjects: emerging considerations for research ethics boards.

PubMed

Buchanan, Elizabeth; Aycock, John; Dexter, Scott; Dittrich, David; Hvizdak, Erin

2011-06-01

This paper explores the growing concerns with computer science research, and in particular, computer security research and its relationship with the committees that review human subjects research. It offers cases that review boards are likely to confront, and provides a context for appropriate consideration of such research, as issues of bots, clouds, and worms enter the discourse of human subjects review.

Enhancement of biological control agents for use against forest insect pests and diseases through biotechnology

NASA Technical Reports Server (NTRS)

Slavicek, James M.

1991-01-01

Research and development efforts in our research group are focused on the generation of more efficacious biological control agents through the techniques of biotechnology for use against forest insect pests and diseases. Effective biological controls for the gypsy moth and for tree fungal wilt pathogens are under development. The successful use of Gypchek, a formulation of the Lymantria dispar nuclear polyhedrosis virus (LdNPV), in gypsy moth control programs has generated considerable interest in that agent. As a consequence of its specificity, LdPNV has negligible adverse ecological impacts compared to most gypsy moth control agents. However, LdNPV is not competitive with other control agents in terms of cost and efficacy. We are investigating several parameters of LdNPV replication and polyhedra production in order to enhance viral potency and efficacy thus mitigating the current disadvantages of LdNPV for gypsy moth control, and have identified LdNPV variants that will facilitate these efforts. Tree endophytic bacteria that synthesize antifungal compounds were identified and an antibiotic compound from one of these bacteria was characterized. The feasibility of developing tree endophytes as biological control agents for tree vascular fungal pathogens is being investigated.

Microbial‐based motor fuels: science and technology

PubMed Central

Wackett, Lawrence P.

2008-01-01

Summary The production of biofuels via microbial biotechnology is a very active field of research. A range of fuel molecule types are currently under consideration: alcohols, ethers, esters, isoprenes, alkenes and alkanes. At the present, the major alcohol biofuel is ethanol. The ethanol fermentation is an old technology. Ongoing efforts aim to increase yield and energy efficiency of ethanol production from biomass. n‐Butanol, another microbial fermentation product, is potentially superior to ethanol as a fuel but suffers from low yield and unwanted side‐products currently. In general, biodiesel fuels consist of fatty acid methyl esters in which the carbon derives from plants, not microbes. A new biodiesel product, called microdiesel, can be generated in engineered bacterial cells that condense ethanol with fatty acids. Perhaps the best fuel type to generate from biomass would be biohydrocarbons. Microbes are known to produce hydrocarbons such as isoprenes, long‐chain alkenes and alkanes. The biochemical mechanisms of microbial hydrocarbon biosynthesis are currently under study. Hydrocarbons and minimally oxygenated molecules may also be produced by hybrid chemical and biological processes. A broad interest in novel fuel molecules is also driving the development of new bioinformatics tools to facilitate biofuels research. PMID:21261841

Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ilinskaya, Anna N.; Dobrovolskaia, Marina A., E-ma

Nanoparticle immunogenicity and antigenicity have been under investigation for many years. During the past decade, significant progress has been made in understanding what makes a nanoparticle immunogenic, how immune cells respond to nanoparticles, what consequences of nanoparticle-specific antibody formation exist and how they challenge the application of nanoparticles for drug delivery. Moreover, it has been recognized that accidental contamination of therapeutic protein formulations with nanosized particulate materials may contribute to the immunogenicity of this type of biotechnology products. While the immunological properties of engineered nanomaterials and their application as vaccine carriers and adjuvants have been given substantial consideration in themore » current literature, little attention has been paid to nanoparticle immuno- and antigenicity. To fill in this gap, we herein provide an overview of this subject to highlight the current state of the field, review past and present research, and discuss future research directions. - Highlights: • Most engineered nanomaterials are not immunogenic per se. • Generation of nanoparticle-specific antibody can be T-cell dependent or independent. • Antibodies can be generated to particle core, terminal groups or surface coatings. • Engineered and accidental nanomaterials have distinct contribution to immunogenicity. • Tunable physicochemical properties make each nanoparticle unique.« less

Self-healing bolted joint employing a shape memory actuator

NASA Astrophysics Data System (ADS)

Muntges, Daniel E.; Park, Gyuhae; Inman, Daniel J.

2001-08-01

This paper is a report of an initial investigation into the active control of preload in the joint using a shape memory actuator around the axis of the bolt shaft. Specifically, the actuator is a cylindrical Nitinol washer that expands axially when heated, according to the shape memory effect. The washer is actuated in response to an artificial decrease in torque. Upon actuation, the stress generated by its axial strain compresses the bolted members and creates a frictional force that has the effect of generating a preload and restoring lost torque. In addition to torque wrenches, the system in question was monitored in all stages of testing using piezoelectric impedance analysis. Impedance analysis drew upon research techniques developed at Center for Intelligent Material Systems and Structures, in which phase changes in the impedance of a self-sensing piezoceramic actuator correspond to changes in joint stiffness. Through experimentation, we have documented a successful actuation of the shape memory element. Due to complexity of constitutive modeling, qualitative analysis by the impedance method is used to illustrate the success. Additional considerations encountered in this initial investigation are made to guide further thorough research required for the successful commercial application of this promising technique.

Future directions for career choice research in nursing: a discussion paper.

PubMed

Price, Sheri

2009-02-01

The last few decades have seen considerable changes in the characteristics of the healthcare workplace and workforce. There is a significant emphasis on recruitment and retention of healthcare providers internationally especially within the profession of Nursing, where there is a critical and growing shortage of nurses. Career choice is a critical component of recruitment and retention strategies and has significant organizational implications in regards to person-environment fit, career satisfaction and commitment. Many extant career choice theories fail to capture the challenges, complexities and uncertainties of the 21st century. Moreover, some early theories do not recognize the unique characteristics of upcoming generational cohorts and the multivariate influences on their career decisions. An extensive review and synthesis of the related literature provide the basis for a critical discussion on the adoption of new methodological approaches to exploring career choice in Nursing. The use of qualitative and mixed method approaches, a focus on generational differences and an exploration of adaptive and adjustment processes to career change provide a foundation for future career choice research and theoretical development which are reflective of the characteristics of the contemporary employee and the reality of modern healthcare organizations.

Assuring safety without animal testing: Unilever's ongoing research programme to deliver novel ways to assure consumer safety.

PubMed

Westmoreland, Carl; Carmichael, Paul; Dent, Matt; Fentem, Julia; MacKay, Cameron; Maxwell, Gavin; Pease, Camilla; Reynolds, Fiona

2010-01-01

Assuring consumer safety without the generation of new animal data is currently a considerable challenge. However, through the application of new technologies and the further development of risk-based approaches for safety assessment, we remain confident it is ultimately achievable. For many complex, multi-organ consumer safety endpoints, the development, evaluation and application of new, non-animal approaches is hampered by a lack of biological understanding of the underlying mechanistic processes involved. The enormity of this scientific challenge should not be underestimated. To tackle this challenge a substantial research programme was initiated by Unilever in 2004 to critically evaluate the feasibility of a new conceptual approach based upon the following key components: 1.Developing new, exposure-driven risk assessment approaches. 2.Developing new biological (in vitro) and computer-based (in silico) predictive models. 3.Evaluating the applicability of new technologies for generating data (e.g. "omics", informatics) and for integrating new types of data (e.g. systems approaches) for risk-based safety assessment. Our research efforts are focussed in the priority areas of skin allergy, cancer and general toxicity (including inhaled toxicity). In all of these areas, a long-term investment is essential to increase the scientific understanding of the underlying biology and molecular mechanisms that we believe will ultimately form a sound basis for novel risk assessment approaches. Our research programme in these priority areas consists of in-house research as well as Unilever-sponsored academic research, involvement in EU-funded projects (e.g. Sens-it-iv, Carcinogenomics), participation in cross-industry collaborative research (e.g. Colipa, EPAA) and ongoing involvement with other scientific initiatives on non-animal approaches to risk assessment (e.g. UK NC3Rs, US "Human Toxicology Project" consortium).

The relationship between an orientation to the future and an orientation to the past: The role of future clarity.

PubMed

Moss, Simon A; Wilson, Samuel G; Irons, Melanie; Naivalu, Carmen

2017-12-01

Some research shows that people who often contemplate their future tend to be healthier. Yet the burgeoning literature on mindfulness demonstrates that people who are more attuned to their immediate experiences also enjoy many benefits. To reconcile these principles, many scholars recommend that people should distribute their attention, somewhat evenly, across the past, present, and future-but have not clarified how people should achieve this goal. We test the possibility that people who perceive their future as vivid and certain, called future clarity, might be able to both orient their attention to the future as well as experience mindfulness. Specifically, future clarity could diminish the inclination of people to reach decisions prematurely and dismiss information that contradicts these decisions, called need for closure-tendencies that diminish consideration of future consequences and mindfulness, respectively. In this cross-sectional study, 194 participants completed measures of mindfulness, consideration of future consequences, need for closure, and future clarity. Consistent with hypotheses, future clarity was positively associated with both mindfulness and consideration of future consequences. Need for closure partly mediated these relationships. Accordingly, interventions that empower people to shape and to clarify their future might generate the benefits of both mindfulness and a future orientation. Copyright © 2017 John Wiley & Sons, Ltd.

PLANTS AS BIO-MONITORS FOR 137CS, 238PU, 239, 240PU AND 40K AT THE SAVANNAH RIVER SITE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caldwell, E.; Duff, M.; Ferguson, C.

2010-12-16

The nuclear fuel cycle generates a considerable amount of radioactive waste, which often includes nuclear fission products, such as strontium-90 ({sup 90}Sr) and cesium-137 ({sup 137}Cs), and actinides such as uranium (U) and plutonium (Pu). When released into the environment, large quantities of these radionuclides can present considerable problems to man and biota due to their radioactive nature and, in some cases as with the actinides, their chemical toxicity. Radionuclides are expected to decay at a known rate. Yet, research has shown the rate of elimination from an ecosystem to differ from the decay rate due to physical, chemical andmore » biological processes that remove the contaminant or reduce its biological availability. Knowledge regarding the rate by which a contaminant is eliminated from an ecosystem (ecological half-life) is important for evaluating the duration and potential severity of risk. To better understand a contaminants impact on an environment, consideration should be given to plants. As primary producers, they represent an important mode of contamination transfer from sediments and soils into the food chain. Contaminants that are chemically and/or physically sequestered in a media are less likely to be bio-available to plants and therefore an ecosystem.« less

Tracking the will to attend: Cortical activity indexes self-generated, voluntary shifts of attention.

PubMed

Gmeindl, Leon; Chiu, Yu-Chin; Esterman, Michael S; Greenberg, Adam S; Courtney, Susan M; Yantis, Steven

2016-10-01

The neural substrates of volition have long tantalized philosophers and scientists. Over the past few decades, researchers have employed increasingly sophisticated technology to investigate this issue, but many studies have been limited considerably by their reliance on intrusive experimental procedures (e.g., abrupt instructional cues), measures of brain activity contaminated by overt behavior, or introspective self-report techniques of questionable validity. Here, we used multivoxel pattern time-course analysis of functional magnetic resonance imaging data to index voluntary, covert perceptual acts-shifts of visuospatial attention-in the absence of instructional cues, overt behavioral indices, and self-report. We found that these self-generated, voluntary attention shifts were time-locked to activity in the medial superior parietal lobule, supporting the hypothesis that this brain region is engaged in voluntary attentional reconfiguration. Self-generated attention shifts were also time-locked to activity in the basal ganglia, a novel finding that motivates further research into the role of the basal ganglia in acts of volition. Remarkably, prior to self-generated shifts of attention, we observed early and selective increases in the activation of medial frontal (dorsal anterior cingulate) and lateral prefrontal (right middle frontal gyrus) cortex-activity that likely reflects processing related to the intention or preparation to reorient attention. These findings, which extend recent evidence on freely chosen motor movements, suggest that dorsal anterior cingulate and lateral prefrontal cortices play key roles in both overt and covert acts of volition, and may constitute core components of a brain network underlying the will to attend.

Tracking the Will to Attend: Cortical Activity Indexes Self-Generated, Voluntary Shifts of Attention

PubMed Central

Gmeindl, Leon; Chiu, Yu-Chin; Esterman, Michael S.; Greenberg, Adam S.; Courtney, Susan M.; Yantis, Steven

2016-01-01

The neural substrates of volition have long tantalized philosophers and scientists. Over the past few decades, researchers have employed increasingly sophisticated technology to investigate this issue, but many studies have been limited considerably by their reliance on intrusive experimental procedures (e.g., abrupt instructional cues), measures of brain activity contaminated by overt behavior, or introspective self-report techniques of questionable validity. Here, we used multivoxel-pattern time-course analysis of functional magnetic resonance imaging data to index voluntary, covert perceptual acts—shifts of visuospatial attention—in the absence of instructional cues, overt behavioral indices, and self-report. We found that these self-generated, voluntary attention shifts were time-locked to activity in the medial superior parietal lobule, supporting the hypothesis that this brain region is engaged in voluntary attentional reconfiguration. Self-generated attention shifts were also time-locked to activity in the basal ganglia, a novel finding that motivates further research into the role of the basal ganglia in acts of volition. Remarkably, prior to self-generated shifts of attention we observed early and selective increases in activation of medial frontal (dorsal anterior cingulate) and lateral prefrontal cortex (right middle frontal gyrus)—activity that likely reflects processing related to the intention or preparation to reorient attention. These findings, which extend recent evidence on freely chosen motor movements, suggest that dorsal anterior cingulate and lateral prefrontal cortices play key roles in both overt and covert acts of volition, and may constitute core components of a brain network underlying the will to attend. PMID:27301353

Sample design effects in landscape genetics

USGS Publications Warehouse

Oyler-McCance, Sara J.; Fedy, Bradley C.; Landguth, Erin L.

2012-01-01

An important research gap in landscape genetics is the impact of different field sampling designs on the ability to detect the effects of landscape pattern on gene flow. We evaluated how five different sampling regimes (random, linear, systematic, cluster, and single study site) affected the probability of correctly identifying the generating landscape process of population structure. Sampling regimes were chosen to represent a suite of designs common in field studies. We used genetic data generated from a spatially-explicit, individual-based program and simulated gene flow in a continuous population across a landscape with gradual spatial changes in resistance to movement. Additionally, we evaluated the sampling regimes using realistic and obtainable number of loci (10 and 20), number of alleles per locus (5 and 10), number of individuals sampled (10-300), and generational time after the landscape was introduced (20 and 400). For a simulated continuously distributed species, we found that random, linear, and systematic sampling regimes performed well with high sample sizes (>200), levels of polymorphism (10 alleles per locus), and number of molecular markers (20). The cluster and single study site sampling regimes were not able to correctly identify the generating process under any conditions and thus, are not advisable strategies for scenarios similar to our simulations. Our research emphasizes the importance of sampling data at ecologically appropriate spatial and temporal scales and suggests careful consideration for sampling near landscape components that are likely to most influence the genetic structure of the species. In addition, simulating sampling designs a priori could help guide filed data collection efforts.

Malaysian researchers talk about the influence of culture on research misconduct in higher learning institutions.

PubMed

Olesen, Angelina P; Amin, Latifah; Mahadi, Zurina

2017-01-01

Based on a previous survey by the Office of Research Integrity (ORI) in the USA, a considerable number of foreign research scientists have been found guilty of research misconduct. However, it remains unclear as to whether or not cultural factors really contribute to research misconduct. This study is based on a series of interviews with Malaysian researchers from the local universities regarding their own professional experiences involving working with researchers or research students from different countries or of different nationalities. Most of the researchers interviewed agreed that cultures do shape individual character, which influences the way that such individuals conduct research, their decision-making, and their style of academic writing. Our findings also showed that working culture within the institution also influences research practices, as well as faculty mentorship of the younger generation of researchers. Given the fact such misconduct might be due to a lack of understanding of research or working cultures or practices within the institution, the impact on the scientific community and on society could be destructive. Therefore, it is suggested that the institution has an important role to play in orienting foreign researchers through training, mentoring, and discussion with regard to the "does" and "don'ts" related to research, and to provide them with an awareness of the importance of ethics when it comes to conducting research.

Development of a Probabilistic Dynamic Synthesis Method for the Analysis of Nondeterministic Structures

NASA Technical Reports Server (NTRS)

Brown, A. M.

1998-01-01

Accounting for the statistical geometric and material variability of structures in analysis has been a topic of considerable research for the last 30 years. The determination of quantifiable measures of statistical probability of a desired response variable, such as natural frequency, maximum displacement, or stress, to replace experience-based "safety factors" has been a primary goal of these studies. There are, however, several problems associated with their satisfactory application to realistic structures, such as bladed disks in turbomachinery. These include the accurate definition of the input random variables (rv's), the large size of the finite element models frequently used to simulate these structures, which makes even a single deterministic analysis expensive, and accurate generation of the cumulative distribution function (CDF) necessary to obtain the probability of the desired response variables. The research presented here applies a methodology called probabilistic dynamic synthesis (PDS) to solve these problems. The PDS method uses dynamic characteristics of substructures measured from modal test as the input rv's, rather than "primitive" rv's such as material or geometric uncertainties. These dynamic characteristics, which are the free-free eigenvalues, eigenvectors, and residual flexibility (RF), are readily measured and for many substructures, a reasonable sample set of these measurements can be obtained. The statistics for these rv's accurately account for the entire random character of the substructure. Using the RF method of component mode synthesis, these dynamic characteristics are used to generate reduced-size sample models of the substructures, which are then coupled to form system models. These sample models are used to obtain the CDF of the response variable by either applying Monte Carlo simulation or by generating data points for use in the response surface reliability method, which can perform the probabilistic analysis with an order of magnitude less computational effort. Both free- and forced-response analyses have been performed, and the results indicate that, while there is considerable room for improvement, the method produces usable and more representative solutions for the design of realistic structures with a substantial savings in computer time.

Practicalities and Research Considerations for Conducting Childhood Obesity Prevention Interventions with Families

PubMed Central

Morgan, Philip J.; Jones, Rachel A.; Collins, Clare E.; Hesketh, Kylie D.; Young, Myles D.; Burrows, Tracy L.; Magarey, Anthea M.; Brown, Helen L.; Hinkley, Trina; Perry, Rebecca A.; Brennan, Leah; Spence, Alison C.; Campbell, Karen J.

2016-01-01

Internationally, childhood obesity is a major public health concern. Given the established difficulties in treating obesity, designing and evaluating effective obesity prevention interventions are research priorities. As parents play a crucial role in establishing positive health behaviours in children, they are a key target for child obesity prevention programs. However, recruiting and engaging parents in such interventions can be a considerable challenge for researchers and practitioners. Members of the ‘Parenting, Child Behaviour and Well-being’ stream of the Australasian Child and Adolescent Obesity Research Network (ACAORN) have considerable and varied expertise in conducting such interventions and can provide insights into addressing these challenges. This paper aims to highlight considerations regarding the design, implementation, and evaluation of obesity prevention interventions with families and provide practical insights and recommendations for researchers and practitioners conducting family-based research in this area. Case studies of three family-based interventions conducted by ACAORN members are highlighted to provide examples and contextualise the recommendations proposed. PMID:27834820

Grid generation for the solution of partial differential equations

NASA Technical Reports Server (NTRS)

Eiseman, Peter R.; Erlebacher, Gordon

1989-01-01

A general survey of grid generators is presented with a concern for understanding why grids are necessary, how they are applied, and how they are generated. After an examination of the need for meshes, the overall applications setting is established with a categorization of the various connectivity patterns. This is split between structured grids and unstructured meshes. Altogether, the categorization establishes the foundation upon which grid generation techniques are developed. The two primary categories are algebraic techniques and partial differential equation techniques. These are each split into basic parts, and accordingly are individually examined in some detail. In the process, the interrelations between the various parts are accented. From the established background in the primary techniques, consideration is shifted to the topic of interactive grid generation and then to adaptive meshes. The setting for adaptivity is established with a suitable means to monitor severe solution behavior. Adaptive grids are considered first and are followed by adaptive triangular meshes. Then the consideration shifts to the temporal coupling between grid generators and PDE-solvers. To conclude, a reflection upon the discussion, herein, is given.

Grid generation for the solution of partial differential equations

NASA Technical Reports Server (NTRS)

Eiseman, Peter R.; Erlebacher, Gordon

1987-01-01

A general survey of grid generators is presented with a concern for understanding why grids are necessary, how they are applied, and how they are generated. After an examination of the need for meshes, the overall applications setting is established with a categorization of the various connectivity patterns. This is split between structured grids and unstructured meshes. Altogether, the categorization establishes the foundation upon which grid generation techniques are developed. The two primary categories are algebraic techniques and partial differential equation techniques. These are each split into basic parts, and accordingly are individually examined in some detail. In the process, the interrelations between the various parts are accented. From the established background in the primary techniques, consideration is shifted to the topic of interactive grid generation and then to adaptive meshes. The setting for adaptivity is established with a suitable means to monitor severe solution behavior. Adaptive grids are considered first and are followed by adaptive triangular meshes. Then the consideration shifts to the temporal coupling between grid generators and PDE-solvers. To conclude, a reflection upon the discussion, herein, is given.

Spatially distributed potential of landfill biogas production and electric power generation in Brazil.

PubMed

Lima, Rodolfo M; Santos, Afonso H M; Pereira, Camilo R S; Flauzino, Bárbara K; Pereira, Ana Cristina O S; Nogueira, Fábio J H; Valverde, José Alfredo R

2018-04-01

Due to the relatively low investment, operation costs, and technical requirements, landfills are still the most widespread alternative for final disposal of municipal solid waste (MSW). The biogas produced in the landfill, a renewable energy source, may be an important alternative for electric power generation. Brazil has a significant number of operating landfills, which receive the most part of the collected MSW. However, the country has only 17 landfill biogas power plants (LBPPs), resulting in about 122 MW of capacity. The United Kingdom, for instance, which is about 3 times smaller than Brazil in population, has 442 LBPPs (corresponding to 1051 MW of capacity). This fact highlights a considerable unexplored potential of landfill biogas in Brazil. It is also important to estimate this potential throughout the country to provide information for the government, researchers and companies in decision making, planning and formulation of public policies regarding this use of landfill biogas. Therefore, this study aims at estimating the spatially distributed potential of landfill biogas production that can be used for electric power generation in Brazil from 2015 to 2045, considering two scenarios: (i) operating sanitary landfills and (ii) hypothetical scenario of Territorial Arrangements (TA) comprising every Brazilian city, considering one landfill per TA. The total installed capacity estimated in 2018 for scenario 1 is about 523 MW and 87% of this number are related to LBPPs bigger than 1 MW. In this same year, the total installed capacity estimated for scenario 2 is 768 MW and 95% of this number are related to LBPPs bigger than 1 MW. These results emphasize that Brazil has a considerable unexplored potential of landfill biogas and the importance of municipal consortiums for MSW management. Copyright © 2017 Elsevier Ltd. All rights reserved.

Giant Landslides, Mega-Tsunamis, and Paleo-Sea Level in the Hawaiian Islands

NASA Astrophysics Data System (ADS)

Watts, P.; McMurtry, G. M.; Fryer, G. J.; Smith, J. R.; Imamura, F.

2001-12-01

We show considerable agreement between the ages of the two giant Alika landslides and dating of debris found tens to hundreds of meters above sea level in Hawaii. Despite the size of the landslides, controversy persists as to the ability to generate landslide tsunamis big enough to deposit the debris. We affirm that tsunami deposits are a sufficient explanation of the observed pattern of debris height. We also show that our tsunami simulations can be used to reduce the considerable uncertainty in subsidence history of the different Hawaiian islands, a current obstacle to interpreting the supposed deposits. Finally, we show that the onset of interglacials provides a probable explanation for the timing of these giant landslides over the last five million years. We predict that the greatest tsunami hazard facing the Hawaiian islands are giant landslides and that the current interglacial promotes the generation of mega-tsunamis from catastrophic volcano collapse. Hawaiian giant submarine landslide events have been recognized from detached submarine landslide blocks and fields of smaller debris by offshore surveys. Mega-tsunamis produced by giant landslides were first proposed for Hawaii and have since been implicated globally at other oceanic islands and along the continental margins. While not discounting the possibility of locally-generated tsunamis, some researchers have cast doubt upon the original hypothesis of giant waves impacting Lanai and other Hawaiian islands from flank failures of the nearby Mauna Loa Volcano on Hawaii island. Landslide tsunami simulations have advanced to the point where the tsunamigenic potential of the giant submarine landslides can be affirmed, while the subsidence history of different Hawaiian islands is still subject to debate.

Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database--UNC GOLD.

PubMed

Gallagher, Sarah A; Smith, Angela B; Matthews, Jonathan E; Potter, Clarence W; Woods, Michael E; Raynor, Mathew; Wallen, Eric M; Rathmell, W Kimryn; Whang, Young E; Kim, William Y; Godley, Paul A; Chen, Ronald C; Wang, Andrew; You, Chaochen; Barocas, Daniel A; Pruthi, Raj S; Nielsen, Matthew E; Milowsky, Matthew I

2014-01-01

The management of genitourinary malignancies requires a multidisciplinary care team composed of urologists, medical oncologists, and radiation oncologists. A genitourinary (GU) oncology clinical database is an invaluable resource for patient care and research. Although electronic medical records provide a single web-based record used for clinical care, billing, and scheduling, information is typically stored in a discipline-specific manner and data extraction is often not applicable to a research setting. A GU oncology database may be used for the development of multidisciplinary treatment plans, analysis of disease-specific practice patterns, and identification of patients for research studies. Despite the potential utility, there are many important considerations that must be addressed when developing and implementing a discipline-specific database. The creation of the GU oncology database including prostate, bladder, and kidney cancers with the identification of necessary variables was facilitated by meetings of stakeholders in medical oncology, urology, and radiation oncology at the University of North Carolina (UNC) at Chapel Hill with a template data dictionary provided by the Department of Urologic Surgery at Vanderbilt University Medical Center. Utilizing Research Electronic Data Capture (REDCap, version 4.14.5), the UNC Genitourinary OncoLogy Database (UNC GOLD) was designed and implemented. The process of designing and implementing a discipline-specific clinical database requires many important considerations. The primary consideration is determining the relationship between the database and the Institutional Review Board (IRB) given the potential applications for both clinical and research uses. Several other necessary steps include ensuring information technology security and federal regulation compliance; determination of a core complete dataset; creation of standard operating procedures; standardizing entry of free text fields; use of data exports, queries, and de-identification strategies; inclusion of individual investigators' data; and strategies for prioritizing specific projects and data entry. A discipline-specific database requires a buy-in from all stakeholders, meticulous development, and data entry resources to generate a unique platform for housing information that may be used for clinical care and research with IRB approval. The steps and issues identified in the development of UNC GOLD provide a process map for others interested in developing a GU oncology database. Copyright © 2014 Elsevier Inc. All rights reserved.

Improving the flow representation in a stochastic programming model for hydropower operations in Chile

NASA Astrophysics Data System (ADS)

Morales, Y.; Olivares, M. A.; Vargas, X.

2015-12-01

This research aims to improve the representation of stochastic water inflows to hydropower plants used in a grid-wide, power production scheduling model in central Chile. The model prescribes the operation of every plant in the system, including hydropower plants located in several basins, and uses stochastic dual dynamic programming (SDDP) with possible inflow scenarios defined from historical records. Each year of record is treated as a sample of weekly inflows to power plants, assuming this intrinsically incorporates spatial and temporal correlations, without any further autocorrelation analysis of the hydrological time series. However, standard good practice suggests the use of synthetic flows instead of raw historical records.The proposed approach generates synthetic inflow scenarios based on hydrological modeling of a few basins in the system and transposition of flows with other basins within so-called homogeneous zones. Hydrologic models use precipitation and temperature as inputs, and therefore this approach requires producing samples of those variables. Development and calibration of these models imply a greater demand of time compared to the purely statistical approach to synthetic flows. This approach requires consideration of the main uses in the basins: agriculture and hydroelectricity. Moreover a geostatistical analysis of the area is analyzed to generate a map that identifies the relationship between the points where the hydrological information is generated and other points of interest within the power system. Consideration of homogeneous zones involves a decrease in the effort required for generation of information compared with hydrological modeling of every point of interest. It is important to emphasize that future scenarios are derived through a probabilistic approach that incorporates the features of the hydrological year type (dry, normal or wet), covering the different possibilities in terms of availability of water resources. We present the results for Maule basin in Chile's Central Interconnected System (SIC).

Funding considerations for the disclosure of genetic incidental findings in biobank research

PubMed Central

Black, L; Avard, D; Zawati, MH; Knoppers, BM; Hébert, J; Sauvageau, G

2013-01-01

The use of biobanks in biomedical research has grown considerably in recent years. As a result of the increasing analysis of tissue samples stored in biobanks, there has also been an increase in the probability of discovering—in addition to the research target—incidental findings (IF). We identified 23 laws, policies and guidelines from international, regional and national organizations that provide guidance or identify the need for the disclosure of IF to research participants. We analyzed these instruments to determine their contemplation of the funding considerations for the disclosure of IF, examining their guidance for who discloses and the extent of researcher responsibilities. We found that the available normative documents provide little guidance to researchers and biobanks for how they should address cost and funding concerns associated with IF disclosure. It is therefore essential that the research and policy communities think through the financial implications of imposing an ethical responsibility to disclose IF. Concerted efforts should be made by policymakers, ethicists, researchers, clinicians and research institutions to develop detailed funding recommendations, potentially universal in application, to aid in the disclosure of IF, and we provide recommendations on steps that can be taken to ensure full consideration of these issues. PMID:23662709

Computational Nanoelectronics and Nanotechnology at NASA ARC

NASA Technical Reports Server (NTRS)

Saini, Subhash; Kutler, Paul (Technical Monitor)

1998-01-01

Both physical and economic considerations indicate that the scaling era of CMOS will run out of steam around the year 2010. However, physical laws also indicate that it is possible to compute at a rate of a billion times present speeds with the expenditure of only one Watt of electrical power. NASA has long-term needs where ultra-small semiconductor devices are needed for critical applications: high performance, low power, compact computers for intelligent autonomous vehicles and Petaflop computing technology are some key examples. To advance the design, development, and production of future generation micro- and nano-devices, IT Modeling and Simulation Group has been started at NASA Ames with a goal to develop an integrated simulation environment that addresses problems related to nanoelectronics and molecular nanotechnology. Overview of nanoelectronics and nanotechnology research activities being carried out at Ames Research Center will be presented. We will also present the vision and the research objectives of the IT Modeling and Simulation Group including the applications of nanoelectronic based devices relevant to NASA missions.

Computational Nanoelectronics and Nanotechnology at NASA ARC

NASA Technical Reports Server (NTRS)

Saini, Subhash

1998-01-01

Both physical and economic considerations indicate that the scaling era of CMOS will run out of steam around the year 2010. However, physical laws also indicate that it is possible to compute at a rate of a billion times present speeds with the expenditure of only one Watt of electrical power. NASA has long-term needs where ultra-small semiconductor devices are needed for critical applications: high performance, low power, compact computers for intelligent autonomous vehicles and Petaflop computing technolpgy are some key examples. To advance the design, development, and production of future generation micro- and nano-devices, IT Modeling and Simulation Group has been started at NASA Ames with a goal to develop an integrated simulation environment that addresses problems related to nanoelectronics and molecular nanotecnology. Overview of nanoelectronics and nanotechnology research activities being carried out at Ames Research Center will be presented. We will also present the vision and the research objectives of the IT Modeling and Simulation Group including the applications of nanoelectronic based devices relevant to NASA missions.

Growing duckweed for biofuel production: a review.

PubMed

Cui, W; Cheng, J J

2015-01-01

Duckweed can be utilised to produce ethanol, butanol and biogas, which are promising alternative energy sources to minimise dependence on limited crude oil and natural gas. The advantages of this aquatic plant include high rate of nutrient (nitrogen and phosphorus) uptake, high biomass yield and great potential as an alternative feedstock for the production of fuel ethanol, butanol and biogas. The objective of this article is to review the published research on growing duckweed for the production of the biofuels, especially starch enrichment in duckweed plants. There are mainly two processes affecting the accumulation of starch in duckweed biomass: photosynthesis for starch generation and metabolism-related starch consumption. The cost of stimulating photosynthesis is relatively high based on current technologies. Considerable research efforts have been made to inhibit starch degradation. Future research need in this area includes duckweed selection, optimisation of duckweed biomass production, enhancement of starch accumulation in duckweeds and use of duckweeds for production of various biofuels. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

Hormonal mechanisms of cooperative behaviour

PubMed Central

Soares, Marta C.; Bshary, Redouan; Fusani, Leonida; Goymann, Wolfgang; Hau, Michaela; Hirschenhauser, Katharina; Oliveira, Rui F.

2010-01-01

Research on the diversity, evolution and stability of cooperative behaviour has generated a considerable body of work. As concepts simplify the real world, theoretical solutions are typically also simple. Real behaviour, in contrast, is often much more diverse. Such diversity, which is increasingly acknowledged to help in stabilizing cooperative outcomes, warrants detailed research about the proximate mechanisms underlying decision-making. Our aim here is to focus on the potential role of neuroendocrine mechanisms on the regulation of the expression of cooperative behaviour in vertebrates. We first provide a brief introduction into the neuroendocrine basis of social behaviour. We then evaluate how hormones may influence known cognitive modules that are involved in decision-making processes that may lead to cooperative behaviour. Based on this evaluation, we will discuss specific examples of how hormones may contribute to the variability of cooperative behaviour at three different levels: (i) within an individual; (ii) between individuals and (iii) between species. We hope that these ideas spur increased research on the behavioural endocrinology of cooperation. PMID:20679116

Engineering Software Suite Validates System Design

NASA Technical Reports Server (NTRS)

2007-01-01

EDAptive Computing Inc.'s (ECI) EDAstar engineering software tool suite, created to capture and validate system design requirements, was significantly funded by NASA's Ames Research Center through five Small Business Innovation Research (SBIR) contracts. These programs specifically developed Syscape, used to capture executable specifications of multi-disciplinary systems, and VectorGen, used to automatically generate tests to ensure system implementations meet specifications. According to the company, the VectorGen tests considerably reduce the time and effort required to validate implementation of components, thereby ensuring their safe and reliable operation. EDASHIELD, an additional product offering from ECI, can be used to diagnose, predict, and correct errors after a system has been deployed using EDASTAR -created models. Initial commercialization for EDASTAR included application by a large prime contractor in a military setting, and customers include various branches within the U.S. Department of Defense, industry giants like the Lockheed Martin Corporation, Science Applications International Corporation, and Ball Aerospace and Technologies Corporation, as well as NASA's Langley and Glenn Research Centers

Tracking Performance of Upgraded "Polished Panel" Optical Receiver on NASA's 34 Meter Research Antenna

NASA Technical Reports Server (NTRS)

Vilnrotter, Victor

2013-01-01

There has been considerable interest in developing and demonstrating a hybrid "polished panel" optical receiver concept that would replace the microwave panels on the Deep Space Network's (DSN) 34 meter antennas with highly polished aluminum panels, thus enabling simultaneous opticaland microwave reception. A test setup has been installed on the 34 meter research antenna at DSS-13 (Deep Space Station 13) at NASA's Goldstone Deep Space Communications Complex in California in order to assess the feasibility of this concept. Here we describe the results of a recent effort todramatically reduce the dimensions of the point-spread function (PSF) generated by a custom polished panel, thus enabling improved optical communications performance. The latest results are compared to the previous configuration in terms of quantifiable PSF improvement. In addition, the performance of acquisition and tracking algorithms designed specifically for the polished panel PSF are evaluated and compared, based on data obtained from real-time tracking of planets and bright stars with the 34 meter research antenna at DSS-13.

Understanding social forces involved in diabetes outcomes: a systems science approach to quality-of-life research.

PubMed

Lounsbury, David W; Hirsch, Gary B; Vega, Chawntel; Schwartz, Carolyn E

2014-04-01

The field of quality-of-life (QOL) research would benefit from learning about and integrating systems science approaches that model how social forces interact dynamically with health and affect the course of chronic illnesses. Our purpose is to describe the systems science mindset and to illustrate the utility of a system dynamics approach to promoting QOL research in chronic disease, using diabetes as an example. We build a series of causal loop diagrams incrementally, introducing new variables and their dynamic relationships at each stage. These causal loop diagrams demonstrate how a common set of relationships among these variables can generate different disease and QOL trajectories for people with diabetes and also lead to a consideration of non-clinical (psychosocial and behavioral) factors that can have implications for program design and policy formulation. The policy implications of the causal loop diagrams are discussed, and empirical next steps to validate the diagrams and quantify the relationships are described.

Recommendations from NASA's Operational and Research Musculoskeletal Summit

NASA Technical Reports Server (NTRS)

Jones, J. A.; Johnson-Throop, K. A.; Scheuring, R. A.; Walton, M. E.; Davis-Street, J. E.; Smaka, T.; McCulley, P. A.; Jones, J. A.; Stokes, C. R.; Parker, K. K.;

Psychosocial Pain Management Moderation: The Limit, Activate, and Enhance Model.

PubMed

Day, Melissa A; Ehde, Dawn M; Jensen, Mark P

2015-10-01

There is a growing emphasis in the pain literature on understanding the following second-order research questions: Why do psychosocial pain treatments work? For whom do various treatments work? This critical review summarizes research that addresses the latter question and proposes a moderation model to help guide future research. A theoretical moderation framework for matching individuals to specific psychosocial pain interventions has been lacking. However, several such frameworks have been proposed in the broad psychotherapy and implementation science literature. Drawing on these theories and adapting them specifically for psychosocial pain treatment, here we propose a Limit, Activate, and Enhance model of pain treatment moderation. This model is unique in that it includes algorithms not only for matching treatments on the basis of patient weaknesses but also for directing patients to interventions that build on their strengths. Critically, this model provides a basis for specific a priori hypothesis generation, and a selection of the possible hypotheses drawn from the model are proposed and discussed. Future research considerations are presented that could refine and expand the model based on theoretically driven empirical evidence. The Limit, Activate, and Enhance model presented here is a theoretically derived framework that provides an a priori basis for hypothesis generation regarding psychosocial pain treatment moderators. The model will advance moderation research via its unique focus on matching patients to specific treatments that (1) limit maladaptive responses, (2) activate adaptive responses, and (3) enhance treatment outcomes based on patient strengths and resources. Copyright © 2015 American Pain Society. Published by Elsevier Inc. All rights reserved.

Researching Lesbian, Gay, and Bisexual Youth: Conceptual, Practical, and Ethical Considerations

ERIC Educational Resources Information Center

D'Augelli, Anthony R.; Grossman, Arnold H.

2006-01-01

Developmental and educational researchers have overlooked the development of sexual orientation among adolescents and youth, even as they study sexual development and identity development during adolescence. This paper examines some conceptual, practical, and ethical considerations involved in conducting research on lesbian, gay, and bisexual…

Methodology for evaluation of railroad technology research projects

DOT National Transportation Integrated Search

1981-04-01

This Project memorandum presents a methodology for evaluating railroad research projects. The methodology includes consideration of industry and societal benefits, with special attention given to technical risks, implementation considerations, and po...

Easier said than done: challenges of applying the Ecohealth approach to the study on heavy metals exposure among indigenous communities of the Peruvian Amazon

PubMed Central

2013-01-01

Background The renewed interest in community participation in health research is linked to its potential for bridging gaps between research and practice. Its main attributes are the generation of knowledge that can lead to socially robust, long-lasting solutions and the creation of a co-learner relationship between researchers and research users. Following this philosophy, Ecohealth has evolved into a specialized framework for participatory research on the impact of pollution on ecosystems and human health. However, its principles pose considerable challenges. Its outcomes are strongly influenced by contextual factors that are impossible to control for ahead of time. This paper describes how the Ecohealth principles were applied to an epidemiological study of heavy metals exposure among indigenous communities of the Peruvian Amazon. It illustrates how knowledge generated from participatory research does not necessarily imply solving a public health problem. This study aimed to contribute to the understanding of the benefits and barriers of following the basic principles of the Ecohealth approach, and assist researchers working in similar contexts. Research process Based upon their personal experience as participant observers, the authors describe the research process; then, they discuss the most important challenges faced, their implications, and the attempted strategies for resolution. Challenges Challenges were grouped into four themes: (1) building trust; (2) one partnership, many stakeholders, multiple agendas; (3) being a researcher; and (4) communicating complex and unexpected findings. Conclusions Integrating the principles of transdisciplinarity and participation posed a series of challenges to the research process that were difficult, and sometimes impossible to overcome. However, positive outcomes from this experience were the lessons learned by the different actors. Despite the lack of immediate action, it is expected that useful interventions to prevent and control lead exposure in the Corrientes population will be implemented in the medium term. PMID:23642035

Development of the psychotherapy supervisor: review of and reflections on 30 years of theory and research.

PubMed

Watkins, C Edward

2012-01-01

The psychotherapy supervisor's development (i.e., the unfolding process of growth in being and becoming a supervisor) has long been considered a substantive issue in clinical supervision. Theory and clinical wisdom suggest that supervisors' level of development can have a significant and far-reaching impact on the supervision experience, potentially affecting supervisory alliance formation, in-session conceptualization and strategy utilization, and even the outcomes experienced by both supervisees and patients. Consensus seems to be that there is a critical need for empirical study of psychotherapy supervisor development. But with a generation of theory and research on psychotherapy supervisor development behind us, what do we know (or not know); where does this area of inquiry stand today, and what do we need to know about supervisor development going forward? In this paper, I attempt to address those questions. I examine the last 30-year period (approximately) of supervisor development theory, measurement, and quantitative and qualitative study; provide a contemporary status report of sorts on this subject; and identify some important matters for research and practical consideration. Despite a generation of inquiry, the psychotherapy supervisor still remains the largely unknown party in the supervision experience. But that long-standing reality can be changed, some possibilities for doing so are presented, and the promise of supervisor development study is seen to be an ever-inviting hope that awaits realization.

Using Digital Technologies in Clinical HIV Research: Real-World Applications and Considerations for Future Work

PubMed Central

Bull, Sheana; Dietrich, Janan; Haberer, Jessica E; Van Der Pol, Barbara; Voronin, Yegor; Wall, Kristin M; Whalen, Christopher; Priddy, Frances

2017-01-01

Background Digital technologies, especially if used in novel ways, provide a number of potential advantages to clinical research in trials related to human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) and may greatly facilitate operations as well as data collection and analysis. These technologies may even allow answering questions that are not answerable with older technologies. However, they come with a variety of potential concerns for both the participants and the trial sponsors. The exact challenges and means for alleviation depend on the technology and on the population in which it is deployed, and the rapidly changing landscape of digital technologies presents a challenge for creating future-proof guidelines for technology application. Objective The aim of this study was to identify and summarize some common themes that are frequently encountered by researchers in this context and highlight those that should be carefully considered before making a decision to include these technologies in their research. Methods In April 2016, the Global HIV Vaccine Enterprise surveyed the field for research groups with recent experience in novel applications of digital technologies in HIV clinical research and convened these groups for a 1-day meeting. Real-world uses of various technologies were presented and discussed by 46 attendees, most of whom were researchers involved in the design and conduct of clinical trials of biomedical HIV prevention and treatment approaches. After the meeting, a small group of organizers reviewed the presentations and feedback obtained during the meeting and categorized various lessons-learned to identify common themes. A group of 9 experts developed a draft summary of the findings that was circulated via email to all 46 attendees for review. Taking into account the feedback received, the group finalized the considerations that are presented here. Results Meeting presenters and attendees discussed the many successful applications of digital technologies to improve research outcomes, such as those for recruitment and enrollment, participant identification, informed consent, data collection, data quality, and protocol or treatment adherence. These discussions also revealed unintended consequence of technology usage, including risks to study participants and risks to study integrity. Conclusions Key lessons learned from these discussions included the need to thoroughly evaluate systems to be used, the idea that early success may not be sustained throughout the study, that some failures will occur, and considerations for study-provided devices. Additionally, taking these key lessons into account, the group generated recommendations on how to move forward with the use of technology in HIV vaccine and biomedical prevention trials. PMID:28760729

Recommendations for Internet-Based Qualitative Health Research With Hard-to-Reach Populations

PubMed Central

Wilkerson, J. Michael; Iantaffi, Alex; Grey, Jeremy A.; Bockting, Walter O.; Simon Rosser, B. R.

2014-01-01

Researchers new to online qualitative health research frequently have questions about how to transfer knowledge of offline data collection to an online environment. In this article, we present best-practice guidelines derived from the literature and our experience to help researchers determine if an online qualitative study design is appropriate for their research project and, if so, when to begin data collection with a hard-to-reach population. Researchers should reflect on administrative, population, and data collection considerations when deciding between online and offline data collection. Decisions must be made regarding whether to conduct interviews or focus groups, to collect data using asynchronous or synchronous methods, and to use only text or incorporate visual media. Researchers should also reflect on human subjects, recruitment, research instrumentation, additional data collection, and public relations considerations when writing protocols to guide the research team’s response to various situations. Our recommendations direct researchers’ reflection on these considerations. PMID:24623662

Ethical Considerations for Cognitive-Behavioral Therapists in Psychotherapy Research Trials

ERIC Educational Resources Information Center

Haman, Kirsten L.; Hollon, Steven D.

2009-01-01

Psychotherapy research studies, which balance the pursuit of knowledge with the provision of treatment, can place unique demands on clinicians, patients, and research staff. However, the literature on ethical considerations in psychotherapy trials is minimal. The current paper depicts CBT community standards of practice in the context of two…

75 FR 27368 - Aerotest Operations, Inc., Aerotest Radiography and Research Reactor; Notice of Consideration of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

...., Aerotest Radiography and Research Reactor; Notice of Consideration of Approval of Transfer and Conforming Amendment, Opportunity for a Hearing, and Order Imposing Procedures for Access to Sensitive Unclassified Non... Manager, Research and Test Reactors Licensing Branch, Division of Policy and Rulemaking, Office of Nuclear...

Architectural Considerations for an Educational Research Center for Child Development (ERCCD).

ERIC Educational Resources Information Center

Linder, Ronald

Architectural considerations and recommendations to facilitate the work of an Educational Research Center for Child Development are presented. The purposes of the center are to demonstrate model programs for children, train student and child development professionals, and facilitate and disseminate research on young children. Program…

Assessing Routing Strategies for Cognitive Radio Sensor Networks

PubMed Central

Zubair, Suleiman; Fisal, Norsheila; Baguda, Yakubu S.; Saleem, Kashif

2013-01-01

Interest in the cognitive radio sensor network (CRSN) paradigm has gradually grown among researchers. This concept seeks to fuse the benefits of dynamic spectrum access into the sensor network, making it a potential player in the next generation (NextGen) network, which is characterized by ubiquity. Notwithstanding its massive potential, little research activity has been dedicated to the network layer. By contrast, we find recent research trends focusing on the physical layer, the link layer and the transport layers. The fact that the cross-layer approach is imperative, due to the resource-constrained nature of CRSNs, can make the design of unique solutions non-trivial in this respect. This paper seeks to explore possible design opportunities with wireless sensor networks (WSNs), cognitive radio ad-hoc networks (CRAHNs) and cross-layer considerations for implementing viable CRSN routing solutions. Additionally, a detailed performance evaluation of WSN routing strategies in a cognitive radio environment is performed to expose research gaps. With this work, we intend to lay a foundation for developing CRSN routing solutions and to establish a basis for future work in this area. PMID:24077319

Earth Radiation Budget Research at the NASA Langley Research Center

NASA Technical Reports Server (NTRS)

Smith, G. Louis; Harrison, Edwin F.; Gibson, Gary G.

2014-01-01

In the 1970s research studies concentrating on satellite measurements of Earth's radiation budget started at the NASA Langley Research Center. Since that beginning, considerable effort has been devoted to developing measurement techniques, data analysis methods, and time-space sampling strategies to meet the radiation budget science requirements for climate studies. Implementation and success of the Earth Radiation Budget Experiment (ERBE) and the Clouds and the Earth's Radiant Energy System (CERES) was due to the remarkable teamwork of many engineers, scientists, and data analysts. Data from ERBE have provided a new understanding of the effects of clouds, aerosols, and El Nino/La Nina oscillation on the Earth's radiation. CERES spacecraft instruments have extended the time coverage with high quality climate data records for over a decade. Using ERBE and CERES measurements these teams have created information about radiation at the top of the atmosphere, at the surface, and throughout the atmosphere for a better understanding of our climate. They have also generated surface radiation products for designers of solar power plants and buildings and numerous other applications

Air Traffic Management Research at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Lee, Katharine

2005-01-01

Since the late 1980's, NASA Ames researchers have been investigating ways to improve the air transportation system through the development of decision support automation. These software advances, such as the Center-TRACON Automation System (eTAS) have been developed with teams of engineers, software developers, human factors experts, and air traffic controllers; some ASA Ames decision support tools are currently operational in Federal Aviation Administration (FAA) facilities and some are in use by the airlines. These tools have provided air traffic controllers and traffic managers the capabilities to help reduce overall delays and holding, and provide significant cost savings to the airlines as well as more manageable workload levels for air traffic service providers. NASA is continuing to collaborate with the FAA, as well as other government agencies, to plan and develop the next generation of decision support tools that will support anticipated changes in the air transportation system, including a projected increase to three times today's air-traffic levels by 2025. The presentation will review some of NASA Ames' recent achievements in air traffic management research, and discuss future tool developments and concepts currently under consideration.

Local vs. volume conductance activity of field potentials in the human subthalamic nucleus

PubMed Central

Marmor, Odeya; Valsky, Dan; Joshua, Mati; Bick, Atira S; Arkadir, David; Tamir, Idit; Bergman, Hagai; Israel, Zvi

2017-01-01

Subthalamic nucleus field potentials have attracted growing research and clinical interest over the last few decades. However, it is unclear whether subthalamic field potentials represent locally generated neuronal subthreshold activity or volume conductance of the organized neuronal activity generated in the cortex. This study aimed at understanding of the physiological origin of subthalamic field potentials and determining the most accurate method for recording them. We compared different methods of recordings in the human subthalamic nucleus: spikes (300–9,000 Hz) and field potentials (3–100 Hz) recorded by monopolar micro- and macroelectrodes, as well as by differential-bipolar macroelectrodes. The recordings were done outside and inside the subthalamic nucleus during electrophysiological navigation for deep brain stimulation procedures (150 electrode trajectories) in 41 Parkinson’s disease patients. We modeled the signal and estimated the contribution of nearby/independent vs. remote/common activity in each recording configuration and area. Monopolar micro- and macroelectrode recordings detect field potentials that are considerably affected by common (probably cortical) activity. However, bipolar macroelectrode recordings inside the subthalamic nucleus can detect locally generated potentials. These results are confirmed by high correspondence between the model predictions and actual correlation of neuronal activity recorded by electrode pairs. Differential bipolar macroelectrode subthalamic field potentials can overcome volume conductance effects and reflect locally generated neuronal activity. Bipolar macroelectrode local field potential recordings might be used as a biological marker of normal and pathological brain functions for future electrophysiological studies and navigation systems as well as for closed-loop deep brain stimulation paradigms. NEW & NOTEWORTHY Our results integrate a new method for human subthalamic recordings with a development of an advanced mathematical model. We found that while monopolar microelectrode and macroelectrode recordings detect field potentials that are considerably affected by common (probably cortical) activity, bipolar macroelectrode recordings inside the subthalamic nucleus (STN) detect locally generated potentials that are significantly different than those recorded outside the STN. Differential bipolar subthalamic field potentials can be used in navigation and closed-loop deep brain stimulation paradigms. PMID:28202569

Research considerations when studying disasters.

PubMed

Cox, Catherine Wilson

2008-03-01

Nurses play an integral role during disasters because they are called upon more than any other health care professional during disaster response efforts; consequently, nurse researchers are interested in studying the issues that impact nurses in the aftermath of a disaster. This article offers research considerations for nurse scientists when developing proposals related to disaster research and identifies resources and possible funding sources for their projects.

Investigation of excitation control for wind-turbine generator stability

NASA Technical Reports Server (NTRS)

Gebben, V. D.

1977-01-01

High speed horizontal axis wind turbine generators with blades on the downwind side of the support tower require special design considerations to handle disturbances introduced by the flow wake behind the tower. Experiments and analytical analyses were made to determine benefits that might be obtained by using the generator exciter to provide system damping for reducing power fluctuations.

Optimization of radiotherapy. Some notes on the principles and practice of optimization in cancer treatment and implications for clinical research.

PubMed

Andrews, J R

1981-01-01

Two methods dominate cancer treatment--one, the traditional best practice, individualized treatment method and two, the a priori determined decision method of the interinstitutional, cooperative, clinical trial. In the first, choices are infinite and can be made at the time of treatment; in the second, choices are finite and are made in advance of treatment on a random basis. Neither method systematically selects, identifies, or formalizes the optimum level of effect in the treatment chosen. Of the two, it can be argued that the first, other things being equal, is more likely to select the optimum treatment. The determination of level of effect for the optimization of cancer treatment requires the generation of dose-response relationships for both benefit and risk and the introduction of benefit and risk considerations and judgements. The clinical trial, as presently constituted, doses not yield this kind of information, it being, generally, of the binary yes or no, better or worse type. The best practice, individualized treatment method can yield, when adequately documented, both a range of dose-response relationships and a variety of benefit and risk considerations. The presentation will be limited to a consideration of a single modality of cancer treatment, radiation therapy, but an analogy with other modalities of cancer treatment will be inferred. Criteria for optimization will be developed and graphic means for its identification and formalization will be demonstrated with examples taken from the radiotherapy literature. The general problem of optimization theory and practice will be discussed; the necessity for its exploration in relation to the increasing complexity of cancer treatment will be developed; and recommendations for clinical research will be made including a proposal for the support of clinics as an alternative to the support of programs.

Acoustic wave propagation in high-pressure system.

PubMed

Foldyna, Josef; Sitek, Libor; Habán, Vladimír

2006-12-22

Recently, substantial attention is paid to the development of methods of generation of pulsations in high-pressure systems to produce pulsating high-speed water jets. The reason is that the introduction of pulsations into the water jets enables to increase their cutting efficiency due to the fact that the impact pressure (so-called water-hammer pressure) generated by an impact of slug of water on the target material is considerably higher than the stagnation pressure generated by corresponding continuous jet. Special method of pulsating jet generation was developed and tested extensively under the laboratory conditions at the Institute of Geonics in Ostrava. The method is based on the action of acoustic transducer on the pressure liquid and transmission of generated acoustic waves via pressure system to the nozzle. The purpose of the paper is to present results obtained during the research oriented at the determination of acoustic wave propagation in high-pressure system. The final objective of the research is to solve the problem of transmission of acoustic waves through high-pressure water to generate pulsating jet effectively even at larger distances from the acoustic source. In order to be able to simulate numerically acoustic wave propagation in the system, it is necessary among others to determine dependence of the sound speed and second kinematical viscosity on operating pressure. Method of determination of the second kinematical viscosity and speed of sound in liquid using modal analysis of response of the tube filled with liquid to the impact was developed. The response was measured by pressure sensors placed at both ends of the tube. Results obtained and presented in the paper indicate good agreement between experimental data and values of speed of sound calculated from so-called "UNESCO equation". They also show that the value of the second kinematical viscosity of water depends on the pressure.

Engine design considerations for 2nd generation supersonic transports

NASA Technical Reports Server (NTRS)

Howlett, R. A.

1975-01-01

The environmental and economic goals projected for advanced supersonic transports will require revolutionary improvements in propulsion systems. Variable cycle engine concepts that incorporate unique components and advanced technologies show promise in meeting these goals. Pratt & Whitney Aircraft is conducting conceptual design studies of variable cycle engine concepts under NASA sponsorship. This paper reviews some of the design considerations for these engine concepts. Emphasis is placed on jet noise abatement, reduction of emissions, performance improvements, installation considerations, hot-section characteristics and control system requirements. Two representative variable cycle engine concepts that incorporate these basic design considerations are described.

Easier said than done: challenges of applying the Ecohealth approach to the study on heavy metals exposure among indigenous communities of the Peruvian Amazon.

PubMed

Anticona, Cynthia; Coe, Anna-Britt; Bergdahl, Ingvar A; San Sebastian, Miguel

2013-05-03

The renewed interest in community participation in health research is linked to its potential for bridging gaps between research and practice. Its main attributes are the generation of knowledge that can lead to socially robust, long-lasting solutions and the creation of a co-learner relationship between researchers and research users. Following this philosophy, Ecohealth has evolved into a specialized framework for participatory research on the impact of pollution on ecosystems and human health. However, its principles pose considerable challenges. Its outcomes are strongly influenced by contextual factors that are impossible to control for ahead of time.This paper describes how the Ecohealth principles were applied to an epidemiological study of heavy metals exposure among indigenous communities of the Peruvian Amazon. It illustrates how knowledge generated from participatory research does not necessarily imply solving a public health problem. This study aimed to contribute to the understanding of the benefits and barriers of following the basic principles of the Ecohealth approach, and assist researchers working in similar contexts. Based upon their personal experience as participant observers, the authors describe the research process; then, they discuss the most important challenges faced, their implications, and the attempted strategies for resolution. Challenges were grouped into four themes: (1) building trust; (2) one partnership, many stakeholders, multiple agendas; (3) being a researcher; and (4) communicating complex and unexpected findings. Integrating the principles of transdisciplinarity and participation posed a series of challenges to the research process that were difficult, and sometimes impossible to overcome. However, positive outcomes from this experience were the lessons learned by the different actors. Despite the lack of immediate action, it is expected that useful interventions to prevent and control lead exposure in the Corrientes population will be implemented in the medium term.

Gas Foil Bearing Technology Advancements for Closed Brayton Cycle Turbines

NASA Technical Reports Server (NTRS)

Howard, Samuel A.; Bruckner, Robert J.; DellaCorte, Christopher; Radil, Kevin C.

2007-01-01

Closed Brayton Cycle (CBC) turbine systems are under consideration for future space electric power generation. CBC turbines convert thermal energy from a nuclear reactor, or other heat source, to electrical power using a closed-loop cycle. The operating fluid in the closed-loop is commonly a high pressure inert gas mixture that cannot tolerate contamination. One source of potential contamination in a system such as this is the lubricant used in the turbomachine bearings. Gas Foil Bearings (GFB) represent a bearing technology that eliminates the possibility of contamination by using the working fluid as the lubricant. Thus, foil bearings are well suited to application in space power CBC turbine systems. NASA Glenn Research Center is actively researching GFB technology for use in these CBC power turbines. A power loss model has been developed, and the effects of a very high ambient pressure, start-up torque, and misalignment, have been observed and are reported here.

A conceptual framework and ethics analysis for prevention trials of Alzheimer Disease.

PubMed

Peters, Kevin R; Lynn Beattie, B; Feldman, Howard H; Illes, Judy

2013-11-01

As our understanding of the neurobiology of Alzheimer Disease deepens, it has become evident that early intervention is critical to achieving successful therapeutic impact. The availability of diagnostic criteria for preclinical Alzheimer Disease adds momentum to research directed at this goal and even to prevention. The landscape of therapeutic research is thus poised to undergo a dramatic shift in the next 5-10 years, with clinical trials involving subjects at risk for Alzheimer Disease who have few or no symptoms. These trials will also likely rely heavily on genetics, biomarkers, and or risk factor stratification to identify individuals at risk for Alzheimer Disease. Here, we propose a conceptual framework to guide this next generation of pharmacological and non-pharmacological clinical pursuit, and discuss some of the foreseeable ethical considerations that may accompany them. Copyright © 2013 Elsevier Ltd. All rights reserved.

Performance of a Turboprop Engine with Heat Recovery in Off-Design Conditions

NASA Astrophysics Data System (ADS)

Andriani, Roberto; Ghezzi, Umberto; Gamma, Fausto; Ingenito, Antonella; Agresta, Antonio

2013-09-01

The research for fuel consumption and pollution reduction in new generation aero engines has indicated intercooling and regeneration as very effective methods for this purpose. Hence, different countries have joined their efforts in common research programs, to develop new gas turbine engines able to reduce considerably the fuel consumption and the ambient impact by means of these two techniques. To study their effects on the engine performance and characteristics, a thermodynamic numerical program that simulates the behavior of a turboprop engine with intercooling and regeneration in different operating conditions has been developed. After the parametric study, and the definition of the design conditions, the off-design analysis is carried on, comparing the main characteristics of the intercooled-regenerated turboprop with those of a conventional engine. Then, once a particular mission profile was fixed, the engine performance, in particular the equivalent power, the fuel consumption and the heat exchanger weight were discussed.

Experiences with the use of axisymmetric elements in cosmic NASTRAN for static analysis

NASA Technical Reports Server (NTRS)

Cooper, Michael J.; Walton, William C.

1991-01-01

Discussed here are some recent finite element modeling experiences using the axisymmetric elements CONEAX, TRAPAX, and TRIAAX, from the COSMIC NASTRAN element library. These experiences were gained in the practical application of these elements to the static analysis of helicopter rotor force measuring systems for two design projects for the NASA Ames Research Center. These design projects were the Rotor Test Apparatus and the Large Rotor Test Apparatus, which are dedicated to basic helicopter research. Here, a genetic axisymmetric model is generated for illustrative purposes. Modeling considerations are discussed, and the advantages and disadvantages of using axisymmetric elements are presented. Asymmetric mechanical and thermal loads are applied to the structure, and single and multi-point constraints are addressed. An example that couples the axisymmetric model to a non-axisymmtric model is demonstrated, complete with DMAP alters. Recommendations for improving the elements and making them easier to use are offered.

Basic and applied research related to the technology of space energy conversion systems

NASA Technical Reports Server (NTRS)

Hertzberg, A.; Mattick, A. T.; Bruckner, A. P.

1988-01-01

The first six months' research effort on the Liquid Droplet Radiator (LDR) focussed on experimental and theoretical studies of radiation by an LDR droplet cloud. Improvements in the diagnostics for the radiation facility have been made which have permitted an accurate experimental test of theoretical predictions of LDR radiation over a wide range of optical depths, using a cloud of Dow silicone oil droplets. In conjunction with these measurements an analysis was made of the evolution of the cylindrical droplet cloud generated by a 2300-hole orifice plate. This analysis indicates that a considerable degree of agglomeration of droplets occurs over the first meter of travel. Theoretical studies have centered on developments of an efficient means of computing the angular scattering distribution from droplets in an LDR droplet cloud, so that a parameter study can be carried out for LDR radiative performance vs fluid optical properties and cloud geometry.

From anatomical 'competence' to complex capability. The views and experiences of UK tutors on how we should teach anatomy to medical students.

PubMed

Regan de Bere, Sam; Mattick, Karen

2010-10-01

Developments in clinical education have recently challenged the identity of anatomy teaching and learning, leading to high profile debate over the potential implications for the competence levels of new doctors. However, the emphasis remains on methods of teaching, rather than a review of what well-rounded anatomical learning actually entails, and how teaching can address contemporary learning needs. This paper identifies and addresses some of these issues, drawing on expert views captured in qualitative research with anatomy tutors at twenty different medical schools in the UK. Three main themes emerging from our analysis are described: anatomy as a subject matter, the challenges of teaching or learning anatomy, and the use of teaching methods. We also detail how inductive analysis generated new hypotheses worthy of further consideration. These fall into two key categories: (1) improving anatomy curriculum design and (2) advancing anatomy education research.

The Food Marketing Defense Model: Integrating Psychological Research to Protect Youth and Inform Public Policy.

PubMed

Harris, Jennifer L; Brownell, Kelly D; Bargh, John A

2009-12-01

Marketing practices that promote calorie-dense, nutrient-poor foods directly to children and adolescents present significant public health risk. Worldwide, calls for government action and industry change to protect young people from the negative effects of food marketing have increased. Current proposals focus on restricting television advertising to children under 12 years old, but current psychological models suggest that much more is required. All forms of marketing pose considerable risk; adolescents are also highly vulnerable; and food marketing may produce far-reaching negative health outcomes. We propose a food marketing defense model that posits four necessary conditions to effectively counter harmful food marketing practices: awareness, understanding, ability and motivation to resist. A new generation of psychological research is needed to examine each of these processes, including the psychological mechanisms through which food marketing affects young people, to identify public policy that will effectively protect them from harmful influence.

Fuel ethanol production: process design trends and integration opportunities.

PubMed

Cardona, Carlos A; Sánchez, Oscar J

2007-09-01

Current fuel ethanol research and development deals with process engineering trends for improving biotechnological production of ethanol. In this work, the key role that process design plays during the development of cost-effective technologies is recognized through the analysis of major trends in process synthesis, modeling, simulation and optimization related to ethanol production. Main directions in techno-economical evaluation of fuel ethanol processes are described as well as some prospecting configurations. The most promising alternatives for compensating ethanol production costs by the generation of valuable co-products are analyzed. Opportunities for integration of fuel ethanol production processes and their implications are underlined. Main ways of process intensification through reaction-reaction, reaction-separation and separation-separation processes are analyzed in the case of bioethanol production. Some examples of energy integration during ethanol production are also highlighted. Finally, some concluding considerations on current and future research tendencies in fuel ethanol production regarding process design and integration are presented.

Aeroacoustic research in wind tunnels: A status report

NASA Technical Reports Server (NTRS)

Bender, J.; Arndt, R. E. A.

1973-01-01

The increasing attention given to aerodynamically generated noise brings into focus the need for quality experimental research in this area. To meet this need several specialized anechoic wind tunnels have been constructed. In many cases, however, budgetary constraints and the like make it desirable to use conventional wind tunnels for this work. Three basic problems are inherent in conventional facilities: (1) high background noise, (2) strong frequency dependent reverberation effects, and (3) unique instrumentation problems. The known acoustic characteristics of several conventional wind tunnels are evaluated and data obtained in a smaller 4- x 5-foot wind tunnel which is convertible from a closed jet to an open jet mode are presented. The data from these tunnels serve as a guideline for proposed modifications to a 7- x 10-foot wind tunnel. Consideration is given to acoustic treatment in several different portions of the wind tunnel.

Basic concepts of depression

PubMed Central

Paykel, Eugene S.

2008-01-01

This paper reviews concepts of depression, including history and classification. The original broad concept of melancholia included all forms of quiet insanity. The term depression began to appear in the nineteenth century as did the modern concept of affective disorders, with the core disturbance now viewed as one of mood. The 1930s saw the introduction of defined criteria into official diagnostic schemes. The modern separation into unipolar and bipolar disorder was introduced following empirical research by Angst and Perris in the 1960s. The partially overlapping distinctions between psychotic and neurotic depression, and between endogenous and reactive depression, started to generate debate in the 1920s, with considerable multivariate research in the 1960s. The symptom element in endogenous depression currently survives in melancholia or somatic syndrome. Life stress is common in various depressive pictures. Dysthymia, a valuable diagnosis, represents a form of what was regarded earlier as neurotic depression. Other subtypes are also discussed. PMID:18979941

The Food Marketing Defense Model: Integrating Psychological Research to Protect Youth and Inform Public Policy

PubMed Central

Harris, Jennifer L.; Brownell, Kelly D.; Bargh, John A.

2009-01-01

Marketing practices that promote calorie-dense, nutrient-poor foods directly to children and adolescents present significant public health risk. Worldwide, calls for government action and industry change to protect young people from the negative effects of food marketing have increased. Current proposals focus on restricting television advertising to children under 12 years old, but current psychological models suggest that much more is required. All forms of marketing pose considerable risk; adolescents are also highly vulnerable; and food marketing may produce far-reaching negative health outcomes. We propose a food marketing defense model that posits four necessary conditions to effectively counter harmful food marketing practices: awareness, understanding, ability and motivation to resist. A new generation of psychological research is needed to examine each of these processes, including the psychological mechanisms through which food marketing affects young people, to identify public policy that will effectively protect them from harmful influence. PMID:20182647

Adapting Knowledge Translation Strategies for Rare Rheumatic Diseases.

PubMed

Cellucci, Tania; Lee, Shirley; Webster, Fiona

2016-08-01

Rare rheumatic diseases present unique challenges to knowledge translation (KT) researchers. There is often an urgent need to transfer knowledge from research findings into clinical practice to facilitate earlier diagnosis and better outcomes. However, existing KT frameworks have not addressed the specific considerations surrounding rare diseases for which gold standard evidence is not available. Several widely adopted models provide guidance for processes and problems associated with KT. However, they do not address issues surrounding creation or synthesis of knowledge for rare diseases. Additional problems relate to lack of awareness or experience in intended knowledge users, low motivation, and potential barriers to changing practice or policy. Strategies to address the challenges of KT for rare rheumatic diseases include considering different levels of evidence available, linking knowledge creation and transfer directly, incorporating patient and physician advocacy efforts to generate awareness of conditions, and selecting strategies to address barriers to practice or policy change.

Considerations for Explosively Driven Conical Shock Tube Design: Computations and Experiments

DTIC Science & Technology

2017-02-16

ARL-TR-7953 ● FEB 2017 US Army Research Laboratory Considerations for Explosively Driven Conical Shock Tube Design : Computations...The findings in this report are not to be construed as an official Department of the Army position unless so designated by other authorized...Considerations for Explosively Driven Conical Shock Tube Designs : Computations and Experiments by Joel B Stewart Weapons and Materials Research Directorate

The analysis of harmonic generation coefficients in the ablative Rayleigh-Taylor instability

NASA Astrophysics Data System (ADS)

Lu, Yan; Fan, Zhengfeng; Lu, Xinpei; Ye, Wenhua; Zou, Changlin; Zhang, Ziyun; Zhang, Wen

2017-10-01

In this research, we use the numerical simulation method to investigate the generation coefficients of the first three harmonics and the zeroth harmonic in the Ablative Rayleigh-Taylor Instability. It is shown that the interface shifts to the low temperature side during the ablation process. In consideration of the third-order perturbation theory, the first three harmonic amplitudes of the weakly nonlinear regime are calculated and then the harmonic generation coefficients are obtained by curve fitting. The simulation results show that the harmonic generation coefficients changed with time and wavelength. Using the higher-order perturbation theory, we find that more and more harmonics are generated in the later weakly nonlinear stage, which is caused by the negative feedback of the later higher harmonics. Furthermore, extending the third-order theory to the fifth-order theory, we find that the second and the third harmonics coefficients linearly depend on the wavelength, while the feedback coefficients are almost constant. Further analysis also shows that when the fifth-order theory is considered, the normalized effective amplitudes of second and third harmonics can reach about 25%-40%, which are only 15%-25% in the frame of the previous third-order theory. Therefore, the third order perturbation theory is needed to be modified by the higher-order theory when ηL reaches about 20% of the perturbation wavelength.

Research ethics consultation: ethical and professional practice challenges and recommendations.

PubMed

Sharp, Richard R; Taylor, Holly A; Brinich, Margaret A; Boyle, Mary M; Cho, Mildred; Coors, Marilyn; Danis, Marion; Havard, Molly; Magnus, David; Wilfond, Benjamin

2015-05-01

The complexity of biomedical research has increased considerably in the last decade, as has the pace of translational research. This complexity has generated a number of novel ethical issues for clinical investigators, institutional review boards (IRBs), and other oversight committees. In response, many academic medical centers have created formal research ethics consultation (REC) services to help clinical investigators and IRBs navigate ethical issues in biomedical research. Key functions of a REC service include assisting with research design and implementation, providing a forum for deliberative exploration of ethical issues, and supplementing regulatory oversight. As increasing numbers of academic research institutions establish REC services, there is a pressing need for consensus about the primary aims and policies that should guide these activities. Establishing clear expectations about the aims and policies of REC services is important if REC programs are to achieve their full potential. Drawing on the experiences of a Clinical and Translational Science Award Research Ethics Consultation Working Group, this article describes three major ethical and professional practice challenges associated with the provision of REC: (1) managing multiple institutional roles and responsibilities, (2) managing sensitive information, and (3) communicating with consultation requestors about how these issues are managed. The paper also presents several practical strategies for addressing these challenges and enhancing the quality of REC services.

Doing Science that Matters to Address India's Water Crisis.

NASA Astrophysics Data System (ADS)

Srinivasan, V.

2017-12-01

Addressing water security in developing regions involves predicting water availability under unprecedented rates of population and economic growth. India is one of the most water stressed countries in the world. Despite appreciable increases in funding for water research, high quality science that is usable by stakeholders remains elusive. The absence of usable research, has been driven by notions of what is publishable in the developed world. This can be attributed to the absence of problem driven research on questions that actually matter to stakeholders, unwillingness to transcend disciplinary boundaries and the demise of a field-work research culture in favour of computer simulation. Yet the combination of rapid change, inadequate data and human modifications to watersheds poses a challenge, as researchers face a poorly constrained water resources modelling problem. Instead, what India and indeed all developing regions need is to approach the problem from first principles, identifying the most critical knowledge gaps, then prioritizing data collection using novel sensing and modelling approaches to address them. This might also necessitate consideration of underlying social and governance drivers of hydrologic change. Using examples from research in the Cauvery Basin, a highly contentious inter-state river basin, I offer some insights into framing "use-inspired" research agenda and show how the research generates not just new scientific insights but may be translated into practice.

Research Ethics Consultation: Ethical and Professional Practice Challenges and Recommendations

PubMed Central

Sharp, Richard R.; Taylor, Holly A.; Brinich, Margaret A.; Boyle, Mary M.; Cho, Mildred; Coors, Marilyn; Danis, Marion; Havard, Molly; Magnus, David; Wilfond, Benjamin

2015-01-01

The complexity of biomedical research has increased considerably in the last decade, as has the pace of translational research. This complexity has generated a number of novel ethical issues for clinical investigators, institutional review boards (IRBs), and other oversight committees. In response, many academic medical centers have created formal research ethics consultation (REC) services to help clinical investigators and IRBs navigate ethical issues in biomedical research. Key functions of a REC service include: assisting with research design and implementation, providing a forum for deliberative exploration of ethical issues, and supplementing regulatory oversight. As increasing numbers of academic research institutions establish REC services, there is a pressing need for consensus about the primary aims and policies that should guide these activities. Establishing clear expectations about the aims and policies of REC services is important if REC programs are to achieve their full potential. Drawing on the experiences of a Clinical Translational Science Award (CTSA) Research Ethics Consultation Working Group, this article describes three major ethical and professional practice challenges associated with the provision of REC: 1) managing multiple institutional roles and responsibilities, 2) managing sensitive information, and 3) communicating with consultation requestors about how these issues are managed. The paper also presents several practical strategies for addressing these challenges and enhancing the quality of REC services. PMID:25607942

Analysis of entropy extraction efficiencies in random number generation systems

NASA Astrophysics Data System (ADS)

Wang, Chao; Wang, Shuang; Chen, Wei; Yin, Zhen-Qiang; Han, Zheng-Fu

2016-05-01

Random numbers (RNs) have applications in many areas: lottery games, gambling, computer simulation, and, most importantly, cryptography [N. Gisin et al., Rev. Mod. Phys. 74 (2002) 145]. In cryptography theory, the theoretical security of the system calls for high quality RNs. Therefore, developing methods for producing unpredictable RNs with adequate speed is an attractive topic. Early on, despite the lack of theoretical support, pseudo RNs generated by algorithmic methods performed well and satisfied reasonable statistical requirements. However, as implemented, those pseudorandom sequences were completely determined by mathematical formulas and initial seeds, which cannot introduce extra entropy or information. In these cases, “random” bits are generated that are not at all random. Physical random number generators (RNGs), which, in contrast to algorithmic methods, are based on unpredictable physical random phenomena, have attracted considerable research interest. However, the way that we extract random bits from those physical entropy sources has a large influence on the efficiency and performance of the system. In this manuscript, we will review and discuss several randomness extraction schemes that are based on radiation or photon arrival times. We analyze the robustness, post-processing requirements and, in particular, the extraction efficiency of those methods to aid in the construction of efficient, compact and robust physical RNG systems.

Research on ethics in two large Human Biomonitoring projects ECNIS and NewGeneris: a bottom up approach.

PubMed

Dumez, Birgit; Van Damme, Karel; Casteleyn, Ludwine

2008-06-05

Assessment of ethical aspects and authorization by ethics committees have become a major constraint for health research including human subjects. Ethical reference values often are extrapolated from clinical settings, where emphasis lies on decisional autonomy and protection of individual's privacy. The question rises if this set of values used in clinical research can be considered as relevant references for HBM research, which is at the basis of public health surveillance. Current and future research activities using human biomarkers are facing new challenges and expectancies on sensitive socio-ethical issues. Reflection is needed on the necessity to balance individual rights against public interest. In addition, many HBM research programs require international collaboration. Domestic legislation is not always easily applicable in international projects. Also, there seem to be considerable inconsistencies in ethical assessments of similar research activities between different countries and even within one country. All this is causing delay and putting the researcher in situations in which it is unclear how to act in accordance with necessary legal requirements. Therefore, analysis of ethical practices and their consequences for HBM research is needed.This analysis will be performed by a bottom-up approach, based on a methodology for comparative analysis of determinants in ethical reasoning, allowing taking into account different social, cultural, political and historical traditions, in view of safeguarding common EU values. Based on information collected in real life complexity, paradigm cases and virtual case scenarios will be developed and discussed with relevant stakeholders to openly discuss possible obstacles and to identify options for improvement in regulation. The material collected will allow developing an ethical framework which may constitute the basis for a more harmonized and consistent socio-ethical and legal approach. This will not only increase the possibilities for comparison between data generated but may also allow for more equality in the protection of the rights of European citizens and establish trustful relationships between science and society, based on firmly rooted ethical values within the EU legislative framework.These considerations outline part of the research on legal, socio-ethical and communication aspects of HBM within the scope of ECNIS (NoE) and NewGeneris (IP).

Research on ethics in two large Human Biomonitoring projects ECNIS and NewGeneris: a bottom up approach

PubMed Central

Dumez, Birgit; Van Damme, Karel; Casteleyn, Ludwine

2008-01-01

Assessment of ethical aspects and authorization by ethics committees have become a major constraint for health research including human subjects. Ethical reference values often are extrapolated from clinical settings, where emphasis lies on decisional autonomy and protection of individual's privacy. The question rises if this set of values used in clinical research can be considered as relevant references for HBM research, which is at the basis of public health surveillance. Current and future research activities using human biomarkers are facing new challenges and expectancies on sensitive socio-ethical issues. Reflection is needed on the necessity to balance individual rights against public interest. In addition, many HBM research programs require international collaboration. Domestic legislation is not always easily applicable in international projects. Also, there seem to be considerable inconsistencies in ethical assessments of similar research activities between different countries and even within one country. All this is causing delay and putting the researcher in situations in which it is unclear how to act in accordance with necessary legal requirements. Therefore, analysis of ethical practices and their consequences for HBM research is needed. This analysis will be performed by a bottom-up approach, based on a methodology for comparative analysis of determinants in ethical reasoning, allowing taking into account different social, cultural, political and historical traditions, in view of safeguarding common EU values. Based on information collected in real life complexity, paradigm cases and virtual case scenarios will be developed and discussed with relevant stakeholders to openly discuss possible obstacles and to identify options for improvement in regulation. The material collected will allow developing an ethical framework which may constitute the basis for a more harmonized and consistent socio-ethical and legal approach. This will not only increase the possibilities for comparison between data generated but may also allow for more equality in the protection of the rights of European citizens and establish trustful relationships between science and society, based on firmly rooted ethical values within the EU legislative framework. These considerations outline part of the research on legal, socio-ethical and communication aspects of HBM within the scope of ECNIS (NoE) and NewGeneris (IP). PMID:18541073

Generating optimal control simulations of musculoskeletal movement using OpenSim and MATLAB.

PubMed

Lee, Leng-Feng; Umberger, Brian R

2016-01-01

Computer modeling, simulation and optimization are powerful tools that have seen increased use in biomechanics research. Dynamic optimizations can be categorized as either data-tracking or predictive problems. The data-tracking approach has been used extensively to address human movement problems of clinical relevance. The predictive approach also holds great promise, but has seen limited use in clinical applications. Enhanced software tools would facilitate the application of predictive musculoskeletal simulations to clinically-relevant research. The open-source software OpenSim provides tools for generating tracking simulations but not predictive simulations. However, OpenSim includes an extensive application programming interface that permits extending its capabilities with scripting languages such as MATLAB. In the work presented here, we combine the computational tools provided by MATLAB with the musculoskeletal modeling capabilities of OpenSim to create a framework for generating predictive simulations of musculoskeletal movement based on direct collocation optimal control techniques. In many cases, the direct collocation approach can be used to solve optimal control problems considerably faster than traditional shooting methods. Cyclical and discrete movement problems were solved using a simple 1 degree of freedom musculoskeletal model and a model of the human lower limb, respectively. The problems could be solved in reasonable amounts of time (several seconds to 1-2 hours) using the open-source IPOPT solver. The problems could also be solved using the fmincon solver that is included with MATLAB, but the computation times were excessively long for all but the smallest of problems. The performance advantage for IPOPT was derived primarily by exploiting sparsity in the constraints Jacobian. The framework presented here provides a powerful and flexible approach for generating optimal control simulations of musculoskeletal movement using OpenSim and MATLAB. This should allow researchers to more readily use predictive simulation as a tool to address clinical conditions that limit human mobility.

Generating optimal control simulations of musculoskeletal movement using OpenSim and MATLAB

PubMed Central

Lee, Leng-Feng

2016-01-01

Computer modeling, simulation and optimization are powerful tools that have seen increased use in biomechanics research. Dynamic optimizations can be categorized as either data-tracking or predictive problems. The data-tracking approach has been used extensively to address human movement problems of clinical relevance. The predictive approach also holds great promise, but has seen limited use in clinical applications. Enhanced software tools would facilitate the application of predictive musculoskeletal simulations to clinically-relevant research. The open-source software OpenSim provides tools for generating tracking simulations but not predictive simulations. However, OpenSim includes an extensive application programming interface that permits extending its capabilities with scripting languages such as MATLAB. In the work presented here, we combine the computational tools provided by MATLAB with the musculoskeletal modeling capabilities of OpenSim to create a framework for generating predictive simulations of musculoskeletal movement based on direct collocation optimal control techniques. In many cases, the direct collocation approach can be used to solve optimal control problems considerably faster than traditional shooting methods. Cyclical and discrete movement problems were solved using a simple 1 degree of freedom musculoskeletal model and a model of the human lower limb, respectively. The problems could be solved in reasonable amounts of time (several seconds to 1–2 hours) using the open-source IPOPT solver. The problems could also be solved using the fmincon solver that is included with MATLAB, but the computation times were excessively long for all but the smallest of problems. The performance advantage for IPOPT was derived primarily by exploiting sparsity in the constraints Jacobian. The framework presented here provides a powerful and flexible approach for generating optimal control simulations of musculoskeletal movement using OpenSim and MATLAB. This should allow researchers to more readily use predictive simulation as a tool to address clinical conditions that limit human mobility. PMID:26835184

Self-Editing: On the Relation Between behavioral and Psycholinguistic Approaches

PubMed Central

Kimberly Epting, L; Critchfield, Thomas S

2006-01-01

In Skinner's (1957) conceptual analysis, the process of self-editing is integral to the dynamic complexities of multiply determined verbal behavior, but the analysis has generated little in the way of an experimental analysis. The majority of scientific work on self-editing has taken place within linguistics and cognitive psycholinguistics. Here we compare and contrast behavioral and cognitive psycholinguistic approaches to self-editing, highlighting points of contact that can be identified despite fundamental differences in theoretical styles. We conclude that the two approaches are not mutually exclusive on all dimensions, and suggest that a consideration of cognitive psycholinguistic research may help to spur an experimental analysis of self-editing from a behavioral perspective. PMID:22478464

Impact of changing the Japanese term for "schizophrenia" for reasons of stereotypical beliefs of schizophrenia in Japanese youth.

PubMed

Takahashi, Hidehiko; Ideno, Takashi; Okubo, Shigetaka; Matsui, Hiroshi; Takemura, Kazuhisa; Matsuura, Masato; Kato, Motoichiro; Okubo, Yoshiro

2009-07-01

The old term for schizophrenia, "Seishin-Bunretsu-Byo" (Mind-Split Disease), has been replaced by "Togo-Shitcho-Sho" (Integration Disorder) in Japan. Stigma research requiring individuals to report personal beliefs is useful but is subject to social desirability bias. Using the Implicit Association Test, a measurement designed to minimize this bias, we assessed the impact of this renaming on the stereotype of schizophrenia held by a younger generation. The old term was strongly associated with "criminal", and this association became significantly weaker with the new term. The strategy of renaming holds considerable promise for tempering negative bias toward this disorder in Japan.

A framework to enhance security of physically unclonable functions using chaotic circuits

NASA Astrophysics Data System (ADS)

Chen, Lanxiang

2018-05-01

As a new technique for authentication and key generation, physically unclonable function (PUF) has attracted considerable attentions, with extensive research results achieved already. To resist the popular machine learning modeling attacks, a framework to enhance the security of PUFs is proposed. The basic idea is to combine PUFs with a chaotic system of which the response is highly sensitive to initial conditions. For this framework, a specific construction which combines the common arbiter PUF circuit, a converter, and the Chua's circuit is given to implement a more secure PUF. Simulation experiments are presented to further validate the framework. Finally, some practical suggestions for the framework and specific construction are also discussed.

Off-farm applications of solar energy in agriculture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berry, R.E.

1980-01-01

Food processing applications make up almost all present off-farm studies of solar energy in agriculture. Research, development and demonstration projects on solar food processing have shown significant progress over the past 3 years. Projects have included computer simulation and mathematical models, hardware and process development for removing moisture from horticultural or animal products, integration of energy conservation with solar energy augmentation in conventional processes, and commercial scale demonstrations. The demonstration projects include solar heated air for drying prunes and raisins, soy beans and onions/garlic; and solar generated steam for orange juice pasteurization. Several new and planned projects hold considerable promisemore » for commerical exploitation in future food processes.« less

Estimation of Magnetic Field Growth and Construction of Adaptive Mesh in Corner Domain for the Magnetostatic Problem in Three-Dimensional Space

NASA Astrophysics Data System (ADS)

Perepelkin, Eugene; Tarelkin, Aleksandr

2018-02-01

A magnetostatics problem arises when searching for the distribution of the magnetic field generated by magnet systems of many physics research facilities, e.g., accelerators. The domain in which the boundary-value problem is solved often has a piecewise smooth boundary. In this case, numerical calculations of the problem require consideration of the solution behavior in the corner domain. In this work we obtained an upper estimation of the magnetic field growth using integral formulation of the magnetostatic problem and propose a method for condensing the differential mesh near the corner domain of the vacuum in the three-dimensional space based on this estimation.

Propulsion system study for Small Transport Aircraft Technology (STAT)

NASA Technical Reports Server (NTRS)

Smith, C. E.; Hirschkron, R.; Warren, R. E.

1981-01-01

Propulsion system technologies applicable to the generation of commuter airline aircraft expected to enter service in the 1990's are identified and evaluated in terms of their impact on aircraft operating economics and fuel consumption. The most promising technologies in the areas of engine, propeller, gearbox, and nacelle design are recommended for future research. Each item under consideration is evaluated relative to a modern baseline engine, the General Electric CT7-5, in a current technology aircraft flying a fixed range and payload. The analysis is presented for two aircraft sizes (30 and 50 passenger), over a range of mission lengths (100 to 1100 km) and fuel costs ($264 to $396 per cu m).

Commercialization, patents and moral assessment of biotechnology products.

PubMed

Hoedemaekers, R

2001-06-01

The biotechnology patent debates have revealed deep moral concerns about basic genetics research, R&D and specific biotechnological products, concerns that are seldom taken into consideration in Technology Assessment. In this paper important moral concerns are examined which appear at the various stages of development of a specific genetic product: a predictive genetic test. The purpose is to illustrate the need for a more contextual approach in technology assessment, which integrates the various forms of interaction between bio-technology and society or societal segments. Such an approach will generate greater insight in the moral issues at all stages of a product's life-cycle and this will facilitate decision-making on the 'morality' of a specific biotechnological product.

Real-World Evidence: What It Is and What It Can Tell Us According to the International Society for Pharmacoepidemiology (ISPE) Comparative Effectiveness Research (CER) Special Interest Group (SIG).

PubMed

Yuan, Hongbo; Ali, M Sanni; Brouwer, Emily S; Girman, Cynthia J; Guo, Jeff J; Lund, Jennifer L; Patorno, Elisabetta; Slaughter, Jonathan L; Wen, Xuerong; Bennett, Dimitri

2018-05-07

On December 8, 2016, the New England Journal of Medicine published a sounding board on Real World Evidence (RWE) 1 by the US Food and Drug Administration (FDA) leadership. While the value of RWE based on nonrandomized observational studies was appreciated, such as for hypothesis generating, safety, and measuring quality in healthcare delivery, the authors expressed concerns on the quality of data sources and the ability of methodologies to control for confounding. In response, we offer a few considerations regarding these concerns. © 2018, The American Society for Clinical Pharmacology and Therapeutics.

CONSIDERATION OF CHILDREN'S DISTINCTIVE SUSCEPTIBILITY IN ENVIRONMENTAL HEALTH STUDIES

EPA Science Inventory

Consideration of children's distinctive susceptibility in environmental health studies.
Pauline Mendola (US EPA, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711)

Children are a particularly susceptible subpopulation with ...

A Mixed Methods Study of Participant Reaction to Domestic Violence Research in Jordan

ERIC Educational Resources Information Center

Clark, Cari Jo; Shahrouri, Manal; Halasa, Louma; Khalaf, Inaam; Spencer, Rachael; Everson-Rose, Susan

2012-01-01

Research on domestic violence against women has increased considerably over the past few decades. Most participants in such studies find the exercise worthwhile and of greater benefit than emotional cost; however, systematic examination of participant reaction to research on violence is considerably lacking, especially in the Middle East region.…

Understanding relevance of health research: considerations in the context of research impact assessment.

PubMed

Dobrow, Mark J; Miller, Fiona A; Frank, Cy; Brown, Adalsteinn D

2017-04-17

With massive investment in health-related research, above and beyond investments in the management and delivery of healthcare and public health services, there has been increasing focus on the impact of health research to explore and explain the consequences of these investments and inform strategic planning. Relevance is reflected by increased attention to the usability and impact of health research, with research funders increasingly engaging in relevance assessment as an input to decision processes. Yet, it is unclear whether relevance is a synonym for or predictor of impact, a necessary condition or stage in achieving it, or a distinct aim of the research enterprise. The main aim of this paper is to improve our understanding of research relevance, with specific objectives to (1) unpack research relevance from both theoretical and practical perspectives, and (2) outline key considerations for its assessment. Our approach involved the scholarly strategy of review and reflection. We prepared a draft paper based on an exploratory review of literature from various fields, and gained from detailed and insightful analysis and critique at a roundtable discussion with a group of key health research stakeholders. We also solicited review and feedback from a small sample of expert reviewers. Research relevance seems increasingly important in justifying research investments and guiding strategic research planning. However, consideration of relevance has been largely tacit in the health research community, often depending on unexplained interpretations of value, fit and potential for impact. While research relevance seems a necessary condition for impact - a process or component of efforts to make rigorous research usable - ultimately, relevance stands apart from research impact. Careful and explicit consideration of research relevance is vital to gauge the overall value and impact of a wide range of individual and collective research efforts and investments. To improve understanding, this paper outlines four key considerations, including how research relevance assessments (1) orientate to, capture and compare research versus non-research sources, (2) consider both instrumental versus non-instrumental uses of research, (3) accommodate dynamic temporal-shifting perspectives on research, and (4) align with an intersubjective understanding of relevance.

A Biological Basis for Generative Learning in Technology-and-Science Part I: A Theory of Learning.

ERIC Educational Resources Information Center

Schaverien, Lynette; Cosgrove, Mark

1999-01-01

Describes a theory of learning in which the brain is seen as a Darwinian machine. Argues that the generative heuristic underlying Darwinism offers considerable value for technology and science education. Contains 33 references. (Author/WRM)

A versatile toolkit for high throughput functional genomics with Trichoderma reesei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schuster, Andre; Bruno, Kenneth S.; Collett, James R.

2012-01-02

The ascomycete fungus, Trichoderma reesei (anamorph of Hypocrea jecorina), represents a biotechnological workhorse and is currently one of the most proficient cellulase producers. While strain improvement was traditionally accomplished by random mutagenesis, a detailed understanding of cellulase regulation can only be gained using recombinant technologies. RESULTS: Aiming at high efficiency and high throughput methods, we present here a construction kit for gene knock out in T. reesei. We provide a primer database for gene deletion using the pyr4, amdS and hph selection markers. For high throughput generation of gene knock outs, we constructed vectors using yeast mediated recombination and thenmore » transformed a T. reesei strain deficient in non-homologous end joining (NHEJ) by spore electroporation. This NHEJ-defect was subsequently removed by crossing of mutants with a sexually competent strain derived from the parental strain, QM9414.CONCLUSIONS:Using this strategy and the materials provided, high throughput gene deletion in T. reesei becomes feasible. Moreover, with the application of sexual development, the NHEJ-defect can be removed efficiently and without the need for additional selection markers. The same advantages apply for the construction of multiple mutants by crossing of strains with different gene deletions, which is now possible with considerably less hands-on time and minimal screening effort compared to a transformation approach. Consequently this toolkit can considerably boost research towards efficient exploitation of the resources of T. reesei for cellulase expression and hence second generation biofuel production.« less

Developing a spinal cord injury research strategy using a structured process of evidence review and stakeholder dialogue. Part II: Background to a research strategy.

PubMed

Bragge, P; Piccenna, L; Middleton, J; Williams, S; Creasey, G; Dunlop, S; Brown, D; Gruen, R

2015-10-01

Literature review/semi-structured interviews. To develop a spinal cord injury (SCI) research strategy for Australia and New Zealand. Australia. The National Trauma Research Institute Forum approach of structured evidence review and stakeholder consultation was employed. This involved gathering from published literature and stakeholder consultation the information necessary to properly consider the challenge, and synthesising this into a briefing document. A research strategy 'roadmap' was developed to define the major steps and key planning questions to consider; next, evidence from published SCI research strategy initiatives was synthesised with information from four one-on-one semi-structured interviews with key SCI research stakeholders to create a research strategy framework, articulating six key themes and associated activities for consideration. These resources, combined with a review of SCI prioritisation literature, were used to generate a list of draft principles for discussion in a structured stakeholder dialogue meeting. The research strategy roadmap and framework informed discussion at a structured stakeholder dialogue meeting of 23 participants representing key SCI research constituencies, results of which are published in a companion paper. These resources could also be of value in other research strategy or planning exercises. This project was funded by the Victorian Transport Accident Commission and the Australian and New Zealand Spinal Cord Injury Network.

Gathering Information on Costs of Service: Some Basic Considerations for Implementation of PURPA,

DTIC Science & Technology

1979-10-01

UNCLASSFIED RAND/P-6b22 ML."’ II I I I ll6lllllUi GATHERING INFORMATION ON COSTS OF .SERVICE: SOME BASIC CONSIDERATIONS FOR IMPLEMENTATION OF PURPA ...CONSIDERATIONS FOR IMPLEMENTATION OF PURPA Jan Paul Acton, Frank Camm, Derek McKay P-6422 October 1979 4v, P ,. . • L .... .S -iii- PREFACE In the period following...the passage of the Public Utility Regulatory Policies Act of 1978( PURPA ) the Federal Energy Regulatory Commission was responsible for the generation

NCI investment in nanotechnology: achievements and challenges for the future.

PubMed

Dickherber, Anthony; Morris, Stephanie A; Grodzinski, Piotr

2015-01-01

Nanotechnology offers an exceptional and unique opportunity for developing a new generation of tools addressing persistent challenges to progress in cancer research and clinical care. The National Cancer Institute (NCI) recognizes this potential, which is why it invests roughly $150 M per year in nanobiotechnology training, research and development. By exploiting the various capacities of nanomaterials, the range of nanoscale vectors and probes potentially available suggests much is possible for precisely investigating, manipulating, and targeting the mechanisms of cancer across the full spectrum of research and clinical care. NCI has played a key role among federal R&D agencies in recognizing early the value of nanobiotechnology in medicine and committing to its development as well as providing training support for new investigators in the field. These investments have allowed many in the research community to pursue breakthrough capabilities that have already yielded broad benefits. Presented here is an overview of how NCI has made these investments with some consideration of how it will continue to work with this research community to pursue paradigm-changing innovations that offer relief from the burdens of cancer. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Investigation on Smart Parts with Embedded Piezoelectric Sensors via Additive Manufacturing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lin, Yirong

The goal of this proposed research is to design, fabricate, and evaluate “smart parts” with embedded sensors for energy systems. The “smart parts” will be fabricated using Electron Beam Melting (EBM) 3D printing technique with built-in piezoceramic sensors. The objectives of the proposed project are: 1) Fabricate energy system related components with embedded sensors, 2) Evaluate the mechanical properties and sensing functionalities of the “smart parts” with embedded piezoceramic sensors, and 3) Assess in-situ sensing capability of energy system parts. The second year’s research of the research is centered on fabrication of the “smart parts” with considerations of overall materialmore » property as well as demonstration of sensing functionalities. The results for the final report are presented here, including all research accomplishment, project management. Details are included such as: how the design and fabrication of sensor packaging could improve the sensor performance, demonstration of “smart parts” sensing capabilities, analysis on the elements that constitute the “smart sensors”, advanced “stop and go” fabrication process, smart injector fabrication using SLM technology, smart injector testing in combustion environments etc. Research results to date have generated several posters and papers.« less

Working More Productively: Tools for Administrative Data

PubMed Central

Roos, Leslie L; Soodeen, Ruth-Ann; Bond, Ruth; Burchill, Charles

2003-01-01

Objective This paper describes a web-based resource () that contains a series of tools for working with administrative data. This work in knowledge management represents an effort to document, find, and transfer concepts and techniques, both within the local research group and to a more broadly defined user community. Concepts and associated computer programs are made as “modular” as possible to facilitate easy transfer from one project to another. Study Setting/Data Sources Tools to work with a registry, longitudinal administrative data, and special files (survey and clinical) from the Province of Manitoba, Canada in the 1990–2003 period. Data Collection Literature review and analyses of web site utilization were used to generate the findings. Principal Findings The Internet-based Concept Dictionary and SAS macros developed in Manitoba are being used in a growing number of research centers. Nearly 32,000 hits from more than 10,200 hosts in a recent month demonstrate broad interest in the Concept Dictionary. Conclusions The tools, taken together, make up a knowledge repository and research production system that aid local work and have great potential internationally. Modular software provides considerable efficiency. The merging of documentation and researcher-to-researcher dissemination keeps costs manageable. PMID:14596394

7 CFR 3403.16 - Other considerations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Other considerations. 3403.16 Section 3403.16 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE SMALL BUSINESS INNOVATION RESEARCH GRANTS PROGRAM...

Plasmon‐Mediated Solar Energy Conversion via Photocatalysis in Noble Metal/Semiconductor Composites

PubMed Central

Wang, Mengye; Ye, Meidan; Iocozzia, James

2016-01-01

Plasmonics has remained a prominent and growing field over the past several decades. The coupling of various chemical and photo phenomenon has sparked considerable interest in plasmon‐mediated photocatalysis. Given plasmonic photocatalysis has only been developed for a relatively short period, considerable progress has been made in improving the absorption across the full solar spectrum and the efficiency of photo‐generated charge carrier separation. With recent advances in fundamental (i.e., mechanisms) and experimental studies (i.e., the influence of size, geometry, surrounding dielectric field, etc.) on plasmon‐mediated photocatalysis, the rational design and synthesis of metal/semiconductor hybrid nanostructure photocatalysts has been realized. This review seeks to highlight the recent impressive developments in plasmon‐mediated photocatalytic mechanisms (i.e., Schottky junction, direct electron transfer, enhanced local electric field, plasmon resonant energy transfer, and scattering and heating effects), summarize a set of factors (i.e., size, geometry, dielectric environment, loading amount and composition of plasmonic metal, and nanostructure and properties of semiconductors) that largely affect plasmonic photocatalysis, and finally conclude with a perspective on future directions within this rich field of research. PMID:27818901

Plasmon-Mediated Solar Energy Conversion via Photocatalysis in Noble Metal/Semiconductor Composites.

PubMed

Wang, Mengye; Ye, Meidan; Iocozzia, James; Lin, Changjian; Lin, Zhiqun

2016-06-01

Plasmonics has remained a prominent and growing field over the past several decades. The coupling of various chemical and photo phenomenon has sparked considerable interest in plasmon-mediated photocatalysis. Given plasmonic photocatalysis has only been developed for a relatively short period, considerable progress has been made in improving the absorption across the full solar spectrum and the efficiency of photo-generated charge carrier separation. With recent advances in fundamental (i.e., mechanisms) and experimental studies (i.e., the influence of size, geometry, surrounding dielectric field, etc.) on plasmon-mediated photocatalysis, the rational design and synthesis of metal/semiconductor hybrid nanostructure photocatalysts has been realized. This review seeks to highlight the recent impressive developments in plasmon-mediated photocatalytic mechanisms (i.e., Schottky junction, direct electron transfer, enhanced local electric field, plasmon resonant energy transfer, and scattering and heating effects), summarize a set of factors (i.e., size, geometry, dielectric environment, loading amount and composition of plasmonic metal, and nanostructure and properties of semiconductors) that largely affect plasmonic photocatalysis, and finally conclude with a perspective on future directions within this rich field of research.

Design Considerations and Research Needs for Expanding the Current Perceptual Model of Spatial Orientation into an In-Cockpit Spatial Disorientation Warning System

DTIC Science & Technology

2016-11-30

USAARL Report No. 2017-07 Design Considerations and Research Needs for Expanding the Current Perceptual Model of Spatial Orientation into an In...Brill5, Angus H. Rupert1 1U.S. Army Aeromedical Research Laboratory 2Laulima Government Solutions, LLC 3National AeroSpace Training and Research ...Center 4Embry-Riddle Aeronautical University 5U.S. Air Force Research Laboratory United States Army Aeromedical Research Laboratory Auditory

Qualitative research in multicultural psychology: philosophical underpinnings, popular approaches, and ethical considerations.

PubMed

Ponterotto, Joseph G

2010-10-01

This article reviews the current and emerging status of qualitative research in psychology. The particular value of diverse philosophical paradigms and varied inquiry approaches to the advancement of psychology generally, and multicultural psychology specifically, is emphasized. Three specific qualitative inquiry approaches anchored in diverse philosophical research paradigms are highlighted: consensual qualitative research, grounded theory, and participatory action research. The article concludes by highlighting important ethical considerations in multicultural qualitative research. PsycINFO Database Record (c) 2010 APA, all rights reserved.

46 CFR 190.01-15 - Special consideration.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 190.01-15 Section 190.01-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 190.01-15 Special consideration. (a) Special consideration will...

Design colloidal particle morphology and self-assembly for coating applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jiang, Shan; Van Dyk, Antony; Maurice, Alvin

The progressive replacement of organic solvent-based coatings by waterborne latex polymer coatings has substantially renovated the coating industry, and generated huge environmental and health benefits. Today, on top of the continuing demand for higher performance and lower costs, the coating industry faces tighter regulation and higher sustainability standards. In addition, the new waterborne coatings have created unique opportunities and challenges in terms of fundamental understanding and research development. To address these challenges, polymer latex binders with diverse particle morphologies have been developed to improve coating performance. Furthermore, colloidal self-assembly has been utilized to help manufacturers make better paint with lessmore » cost. In this report, we review the recent progress in both fundamental study and industrial application in the context of developing new generation architectural coating materials. We introduce the basic concepts in coating materials and showcase several key technologies that have been implemented to improve coating performance. As a result, these technologies also represent the most important considerations in architectural coating design.« less

The Natural Gas Dilemma in New England's Electricity Sector: Experts' Perspectives on Long Term Climate Issues and Policy Opportunities

NASA Astrophysics Data System (ADS)

Griffith, Steven

This thesis is an interpretive analysis of experts' perspectives on the climate implications of New England's reliance on natural gas for electricity generation. Specifically, this research, conducted through interviews and literature review, examines experts' opinions on the desired role of natural gas within the regional electricity sector, alternative energy resources, and state and regional policy opportunities toward the achievement of New England's ambitious long-term greenhouse gas reduction goals. Experts expressed concern about the climate dilemma posed by a dependence on natural gas. However, interviews revealed that short-term reliability and cost considerations are paramount for many experts, and therefore a reliance on natural gas is the existing reality. To incentivize renewable generation technologies for the purposes of long-term climate stabilization, experts advocated for the expanded implementation of renewable portfolio standard, net metering, and feed-in tariff policies. More broadly, interviewees expressed the need for an array of complementary state and regional policies.

The Ξ* and Ωη Interaction Within a Chiral Unitary Approach

NASA Astrophysics Data System (ADS)

Xu, Si-Qi; Xie, Ju-Jun; Chen, Xu-Rong; Jia, Duo-Jie

2016-01-01

In this work we study the interaction of the coupled channels Ωη and {\\Xi}\\ast\\bar{K} within the chiral unitary approach. The systems under consideration have total isospins 0, strangeness S = -3, and spin 3/2. We study the s wave interaction which implies that the possible resonances generated in the system can have spin-parity JP = 3/2-. The unitary amplitudes in coupled channels develop poles that can be associated with some known baryonic resonances. We find there is a dynamically generated 3/2- Ω state with mass around 1800 MeV, which is in agreement with the predictions of the five-quark model. Supported by the National Basic Research Program (973 Program Grant No. 2014CB845406), and the National Natural Science Foundation of China under Grant Nos. 11475227, 11265014, and the Open Project Program of State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, China No. Y5KF151CJ1

Topical Microbicides and HIV Prevention in the Female Genital Tract

PubMed Central

Cottrell, Mackenzie L; Kashuba, Angela D. M.

2014-01-01

Worldwide, HIV disproportionately affects women who are often unable to negotiate traditional HIV preventive strategies such as condoms. In the absence of an effective vaccine or cure, chemoprophylaxis may be a valuable self-initiated alternative. Topical microbicides have been investigated as one such option. The first generation topical microbicides were non-specific, broad-spectrum antimicrobial agents, including surfactants, polyanions, and acid buffering gels, that generally exhibited contraceptive properties. After extensive clinical study, none prevented HIV infection, and their development was abandoned. Second generation topical microbicides include agents with selective mechanisms of antiviral activity. Most are currently being used for, or have previously been explored as, drugs for treatment of HIV. The most advanced of these is tenofovir 1% gel: the first topical agent shown to significantly reduce HIV infection by 39% compared to placebo. This review summarizes the evolution of topical microbicides for HIV chemoprophylaxis, highlights important concepts learned, and offers current and future considerations for this area of research. PMID:24664786

Design colloidal particle morphology and self-assembly for coating applications

DOE PAGES

Jiang, Shan; Van Dyk, Antony; Maurice, Alvin; ...

2017-05-04

The progressive replacement of organic solvent-based coatings by waterborne latex polymer coatings has substantially renovated the coating industry, and generated huge environmental and health benefits. Today, on top of the continuing demand for higher performance and lower costs, the coating industry faces tighter regulation and higher sustainability standards. In addition, the new waterborne coatings have created unique opportunities and challenges in terms of fundamental understanding and research development. To address these challenges, polymer latex binders with diverse particle morphologies have been developed to improve coating performance. Furthermore, colloidal self-assembly has been utilized to help manufacturers make better paint with lessmore » cost. In this report, we review the recent progress in both fundamental study and industrial application in the context of developing new generation architectural coating materials. We introduce the basic concepts in coating materials and showcase several key technologies that have been implemented to improve coating performance. As a result, these technologies also represent the most important considerations in architectural coating design.« less

CAP: A Computer Code for Generating Tabular Thermodynamic Functions from NASA Lewis Coefficients. Revised

NASA Technical Reports Server (NTRS)

Zehe, Michael J.; Gordon, Sanford; McBride, Bonnie J.

2002-01-01

For several decades the NASA Glenn Research Center has been providing a file of thermodynamic data for use in several computer programs. These data are in the form of least-squares coefficients that have been calculated from tabular thermodynamic data by means of the NASA Properties and Coefficients (PAC) program. The source thermodynamic data are obtained from the literature or from standard compilations. Most gas-phase thermodynamic functions are calculated by the authors from molecular constant data using ideal gas partition functions. The Coefficients and Properties (CAP) program described in this report permits the generation of tabulated thermodynamic functions from the NASA least-squares coefficients. CAP provides considerable flexibility in the output format, the number of temperatures to be tabulated, and the energy units of the calculated properties. This report provides a detailed description of input preparation, examples of input and output for several species, and a listing of all species in the current NASA Glenn thermodynamic data file.

CAP: A Computer Code for Generating Tabular Thermodynamic Functions from NASA Lewis Coefficients

NASA Technical Reports Server (NTRS)

Zehe, Michael J.; Gordon, Sanford; McBride, Bonnie J.

2001-01-01

For several decades the NASA Glenn Research Center has been providing a file of thermodynamic data for use in several computer programs. These data are in the form of least-squares coefficients that have been calculated from tabular thermodynamic data by means of the NASA Properties and Coefficients (PAC) program. The source thermodynamic data are obtained from the literature or from standard compilations. Most gas-phase thermodynamic functions are calculated by the authors from molecular constant data using ideal gas partition functions. The Coefficients and Properties (CAP) program described in this report permits the generation of tabulated thermodynamic functions from the NASA least-squares coefficients. CAP provides considerable flexibility in the output format, the number of temperatures to be tabulated, and the energy units of the calculated properties. This report provides a detailed description of input preparation, examples of input and output for several species, and a listing of all species in the current NASA Glenn thermodynamic data file.

Micro-bubble emission boiling with the cavitation bubble blow pit

PubMed Central

Inada, Shigeaki; Shinagawa, Kazuaki; Illias, Suhaimi Bin; Sumiya, Hiroyuki; Jalaludin, Helmisyah A.

2016-01-01

The miniaturization boiling (micro-bubble emission boiling [MEB]) phenomenon, with a high heat removal capacity that contributes considerably to the cooling of the divertor of the nuclear fusion reactor, was discovered in the early 1980s. Extensive research on MEB has been performed since its discovery. However, the progress of the application has been delayed because the generation mechanism of MEB remains unclear. Reasons for this lack of clarity include the complexity of the phenomenon itself and the high-speed phase change phenomenon in which boiling and condensation are rapidly generated. In addition, a more advanced thermal technique is required to realize the MEB phenomenon at the laboratory scale. To the authors’ knowledge, few studies have discussed the rush mechanism of subcooled liquid to the heating surface, which is critical to elucidating the mechanism behind MEB. This study used photographic images to verify that the cavitation phenomenon spreads to the inside of the superheated liquid on the heating surface and thus clarify the mechanism of MEB. PMID:27628271

Who we were and who we will be: the temporal context of women's in-group stereotype content.

PubMed

Morton, Thomas A; Rabinovich, Anna; Postmes, Tom

2012-06-01

Research has elaborated considerably on the dimensions of out-group stereotype content and on the origins and functions of different content combinations. Less attention has been given to the origins and functions of in-group stereotype content. We argue that in-group stereotypes are likely to serve different social identity functions, and thus attract different content, dependent on individual differences in in-group identification and on the temporal perspective of the perceiver. Two studies (Ns = 43 and 93) found that women's in-group stereotype content varied as a function of gender group identification and temporal perspective. When the past was primed, highly identified women generated stereotypes that emphasized the warmth (but not competence) of their group. When the future was primed, highly identified women generated stereotypes that emphasized the competence (as well as warmth) of their group. These results are discussed in terms of the use of stereotypes for social creativity versus social change. © 2012 The British Psychological Society.

Artificial Intelligence Application in Power Generation Industry: Initial considerations

NASA Astrophysics Data System (ADS)

Ismail, Rahmat Izaizi B.; Ismail Alnaimi, Firas B.; AL-Qrimli, Haidar F.

2016-03-01

With increased competitiveness in power generation industries, more resources are directed in optimizing plant operation, including fault detection and diagnosis. One of the most powerful tools in faults detection and diagnosis is artificial intelligence (AI). Faults should be detected early so correct mitigation measures can be taken, whilst false alarms should be eschewed to avoid unnecessary interruption and downtime. For the last few decades there has been major interest towards intelligent condition monitoring system (ICMS) application in power plant especially with AI development particularly in artificial neural network (ANN). ANN is based on quite simple principles, but takes advantage of their mathematical nature, non-linear iteration to demonstrate powerful problem solving ability. With massive possibility and room for improvement in AI, the inspiration for researching them are apparent, and literally, hundreds of papers have been published, discussing the findings of hybrid AI for condition monitoring purposes. In this paper, the studies of ANN and genetic algorithm (GA) application will be presented.

Pollen dispersal by catapult: Experiments of Lyman J. Briggs on the flower of mountain laurel

USGS Publications Warehouse

Nimmo, John R.; Hermann, Paula M.; Kirkham, M.B.; Landa, Edward R.

2014-01-01

The flower of Kalmia latifolia L. employs a catapult mechanism that flings its pollen to considerable distances. Physicist Lyman J. Briggs investigated this phenomenon in the 1950s after retiring as longtime director of the National Bureau of Standards, attempting to explain how hydromechanical effects inside the flower’s stamen could make it possible. Briggs’s unfinished manuscript implies that liquid under negative pressure generates stress, which, superimposed on the stress generated from the flower’s growth habit, results in force adequate to propel the pollen as observed. With new data and biophysical understanding to supplement Briggs’s experimental results and research notes, we show that his postulated negative-pressure mechanism did not play the exclusive and crucial role that he credited to it, though his revisited investigation sheds light on various related processes. Important issues concerning the development and reproductive function of Kalmia flowers remain unresolved, highlighting the need for further biophysical advances.

Gender and creativity: an overview of psychological and neuroscientific literature.

PubMed

Abraham, Anna

2016-06-01

The topic of gender differences in creativity is one that generates substantial scientific and public interest, but also courts considerable controversy. Owing to the heterogeneous nature of the findings associated with this line of research, the general picture often appears puzzling or obscure. This article presents a selective overview of psychological and neuroscientific literature that has a relevant bearing on the theme of gender and creativity. Topics that are explored include the definition and methods of assessing creativity, a summary of behavioral investigations on gender in relation to creativity, postulations that have been put forward to understand gender differences in creative achievement, gender-based differences in the structure and function of the brain, gender-related differences in behavioral performance on tasks of normative cognition, and neuroscientific studies of gender and creativity. The article ends with a detailed discussion of the idea that differences between men and women in creative cognition are best explained with reference to the gender-dependent adopted strategies or cognitive style when faced with generative tasks.

Permanent-Magnet Motors and Generators for Aircraft

NASA Technical Reports Server (NTRS)

Echolds, E. F.

1983-01-01

Electric motors and generators that use permarotating machinery, but aspects of control and power conditioning are also considered. The discussion is structured around three basic areas: rotating machine design considerations presents various configuration and material options, generator applications provides insight into utilization areas and shows actual hardware and test results, and motor applications provides the same type of information for drive systems.

The RICORDO approach to semantic interoperability for biomedical data and models: strategy, standards and solutions

PubMed Central

2011-01-01

Background The practice and research of medicine generates considerable quantities of data and model resources (DMRs). Although in principle biomedical resources are re-usable, in practice few can currently be shared. In particular, the clinical communities in physiology and pharmacology research, as well as medical education, (i.e. PPME communities) are facing considerable operational and technical obstacles in sharing data and models. Findings We outline the efforts of the PPME communities to achieve automated semantic interoperability for clinical resource documentation in collaboration with the RICORDO project. Current community practices in resource documentation and knowledge management are overviewed. Furthermore, requirements and improvements sought by the PPME communities to current documentation practices are discussed. The RICORDO plan and effort in creating a representational framework and associated open software toolkit for the automated management of PPME metadata resources is also described. Conclusions RICORDO is providing the PPME community with tools to effect, share and reason over clinical resource annotations. This work is contributing to the semantic interoperability of DMRs through ontology-based annotation by (i) supporting more effective navigation and re-use of clinical DMRs, as well as (ii) sustaining interoperability operations based on the criterion of biological similarity. Operations facilitated by RICORDO will range from automated dataset matching to model merging and managing complex simulation workflows. In effect, RICORDO is contributing to community standards for resource sharing and interoperability. PMID:21878109

Interprofessional student clinics: an economic evaluation of collaborative clinical placement education.

PubMed

Haines, Terry P; Kent, Fiona; Keating, Jennifer L

2014-07-01

Interprofessional student clinics can be used to create clinical education placements for health professional students in addition to traditional hospital-based placements and present an opportunity to provide interprofessional learning experiences in a clinical context. To date, little consideration has been given in research literature as to whether such clinics are economically viable for a university to run. We conducted an economic evaluation based upon data generated during a pilot of an interprofessional student clinic based in Australia. Cost-minimization analyses of the student clinic as opposed to traditional profession-specific clinical education in hospitals were conducted from university, Commonwealth Government, state government and societal perspectives. Cost data gathered during the pilot study and market prices were used where available, while $AUD currency at 2011 values were used. Per student day of clinical education, the student clinic cost an additional $289, whereas the state government saved $49 and the Commonwealth Government saved $66. Overall, society paid an additional $175 per student day of clinical education using the student clinic as opposed to conventional hospital-based placements, indicating that traditional hospital-based placements are a cost-minimizing approach overall for providing clinical education. Although interprofessional student clinics have reported positive patient and student learning outcomes, further research is required to determine if these benefits can justify the additional cost of this model of education. Considerations for clinic sustainability are proposed.

Lessons from community-based payment for ecosystem service schemes: from forests to rangelands.

PubMed

Dougill, Andrew J; Stringer, Lindsay C; Leventon, Julia; Riddell, Mike; Rueff, Henri; Spracklen, Dominick V; Butt, Edward

2012-11-19

Climate finance investments and international policy are driving new community-based projects incorporating payments for ecosystem services (PES) to simultaneously store carbon and generate livelihood benefits. Most community-based PES (CB-PES) research focuses on forest areas. Rangelands, which store globally significant quantities of carbon and support many of the world's poor, have seen little CB-PES research attention, despite benefitting from several decades of community-based natural resource management (CBNRM) projects. Lessons from CBNRM suggest institutional considerations are vital in underpinning the design and implementation of successful community projects. This study uses documentary analysis to explore the institutional characteristics of three African community-based forest projects that seek to deliver carbon-storage and poverty-reduction benefits. Strong existing local institutions, clear land tenure, community control over land management decision-making and up-front, flexible payment schemes are found to be vital. Additionally, we undertake a global review of rangeland CBNRM literature and identify that alongside the lessons learned from forest projects, rangeland CB-PES project design requires specific consideration of project boundaries, benefit distribution, capacity building for community monitoring of carbon storage together with awareness-raising using decision-support tools to display the benefits of carbon-friendly land management. We highlight that institutional analyses must be undertaken alongside improved scientific studies of the carbon cycle to enable links to payment schemes, and for them to contribute to poverty alleviation in rangelands.

Lessons from community-based payment for ecosystem service schemes: from forests to rangelands

PubMed Central

Dougill, Andrew J.; Stringer, Lindsay C.; Leventon, Julia; Riddell, Mike; Rueff, Henri; Spracklen, Dominick V.; Butt, Edward

2012-01-01

Climate finance investments and international policy are driving new community-based projects incorporating payments for ecosystem services (PES) to simultaneously store carbon and generate livelihood benefits. Most community-based PES (CB-PES) research focuses on forest areas. Rangelands, which store globally significant quantities of carbon and support many of the world's poor, have seen little CB-PES research attention, despite benefitting from several decades of community-based natural resource management (CBNRM) projects. Lessons from CBNRM suggest institutional considerations are vital in underpinning the design and implementation of successful community projects. This study uses documentary analysis to explore the institutional characteristics of three African community-based forest projects that seek to deliver carbon-storage and poverty-reduction benefits. Strong existing local institutions, clear land tenure, community control over land management decision-making and up-front, flexible payment schemes are found to be vital. Additionally, we undertake a global review of rangeland CBNRM literature and identify that alongside the lessons learned from forest projects, rangeland CB-PES project design requires specific consideration of project boundaries, benefit distribution, capacity building for community monitoring of carbon storage together with awareness-raising using decision-support tools to display the benefits of carbon-friendly land management. We highlight that institutional analyses must be undertaken alongside improved scientific studies of the carbon cycle to enable links to payment schemes, and for them to contribute to poverty alleviation in rangelands. PMID:23045714

Legal, ethical and practical considerations in research involving nurses with dyslexia.

PubMed

Gillin, Nicola

2015-09-01

To discuss the legal, ethical and practical considerations in UK studies involving nurses with dyslexia and medication administration errors (MAEs). Nurses with dyslexia are a vulnerable population as they are susceptible to misrepresentation in research, especially that which involves a sensitive topic such as MAEs. Nurses with dyslexia may be particularly vulnerable to research that could exploit, implicate or attribute unsafe practice to them and their disability. Special consideration should be exercised when researching this population. Despite the potential for legal, ethical and practical issues, MAEs and nurses with dyslexia are under-researched areas and warrant further research. Benefits can be gained, not only by participants but also those with a vested interest in how best to support dyslexic nurses in clinical practice. Through effective design, risks can be identified and minimised, and the research made viable, ethically sound and ultimately beneficial to all those involved.

Cannabinergic pain medicine: a concise clinical primer and survey of randomized-controlled trial results.

PubMed

Aggarwal, Sunil K

2013-02-01

This article attempts to cover pragmatic clinical considerations involved in the use of cannabinergic medicines in pain practice, including geographical and historical considerations, pharmacokinetics, pharmacodynamics, adverse effects, drug interactions, indications, and contraindications. Topics include molecular considerations such as the 10-fold greater abundance of cannabinoid type 1 receptors compared to µ-opioid receptors in the central nervous system and anatomic distributions of cannabinoid receptors in pain circuits. The article uses a narrative review methodology drawing from authoritative textbooks and journals of cannabinoid medicine, Food and Drug Administration-approved cannabinoid drug labels, and current and historical pain medicine literature to address core clinical considerations. To survey the current evidence base for pain management with cannabinergic medicines, a targeted PubMed search was performed to survey the percentage of positive and negative published randomized-controlled trial (RCT) results with this class of pain medicines, using appropriate search limit parameters and the keyword search string "cannabinoid OR cannabis-based AND pain." Of the 56 hits generated, 38 published RCTs met the survey criteria. Of these, 71% (27) concluded that cannabinoids had empirically demonstrable and statistically significant pain-relieving effects, whereas 29% (11) did not. Cannabis and other cannabinergic medicines' efficacies for relieving pain have been studied in RCTs, most of which have demonstrated a beneficial effect for this indication, although most trials are short-term. Adverse effects are generally nonserious and well tolerated. Incorporating cannabinergic medicine topics into pain medicine education seems warranted and continuing clinical research and empiric treatment trials are appropriate.

Age-related factors in the relationship between foot measurements and living stature and body weight.

PubMed

Atamturk, Derya; Duyar, Izzet

2008-11-01

The measurements of feet and footprints are especially important in forensic identification, as they have been used to predict the body height and weight of victims or suspects. It can be observed that the subjects of forensic-oriented studies are generally young adults. That is to say, researchers rarely take into consideration the body's proportional changes with age. Hence, the aim of this study is to generate equations which take age and sex into consideration, when stature and body weight are estimated from foot and footprints dimensions. With this aim in mind, we measured the stature, body weight, foot length and breadth, heel breadth, footprint length and breadth, and footprint heel breadth of 516 volunteers (253 males and 263 females) aged between 17.6 and 82.9 years using standard measurement techniques. The sample population was divided randomly into two groups. Group 1, the study group, consisted of 80% of the sample (n = 406); the remaining 20% were assigned to the cross-validation group or Group 2 (n = 110). In the first stage of the study, we produced equations for estimating stature and weight using a stepwise regression technique. Then, their reliability was tested on Group 2 members. Statistical analyses showed that the ratios of foot dimensions to stature and body weight change considerably with age and sex. Consequently, the regression equations which include these variables yielded more reliable results. Our results indicated that age and sex should be taken into consideration when predicting human body height and weight for forensic purposes.

Responsible Conduct of Research Assessment of Doctor of Education Candidates, Graduate Faculty, and Curriculum Considerations

ERIC Educational Resources Information Center

Thompson, Carla J.

2014-01-01

The study included an assessment of doctoral students, graduate faculty, and curriculum considerations to determine the degree of infusion of research integrity and responsible conduct of research (RCR) principles within a Doctor of Education program. Study results showed substantial increases in doctoral candidates' knowledge levels of RCR,…

Design considerations for a LORAN-C timing receiver in a hostile signal to noise environment

NASA Technical Reports Server (NTRS)

Porter, J. W.; Bowell, J. R.; Price, G. E.

1981-01-01

The environment in which a LORAN-C Timing Receiver may function effectively depends to a large extent on the techniques utilized to insure that interfering signals within the pass band of the unit are neutralized. The baseline performance manually operated timing receivers is discussed and the basic design considerations and necessary parameters for an automatic unit utilizing today's technology are established. Actual performance data is presented comparing the results obtained from a present generation timing receiver against a new generation microprocessor controlled automatic acquisition receiver. The achievements possible in a wide range of signal to noise situations are demonstrated.

Evaluating the Dimensionality of Pornography.

PubMed

Busby, Dean M; Chiu, Hsin-Yao; Olsen, Joseph A; Willoughby, Brian J

2017-08-01

Pornography may be a construct with a single trait or one with many traits. Research in the past was inconsistent in this regard with most researchers assuming that pornography was unidimensional (with one single trait of pornography). However, the considerable amounts of residual variation found in these studies beyond that explained by the single trait hints at what might be a multidimensional construct (with multiple traits such as sensitization and differentiation). Consequently, in this study, we intended to address the question of whether pornography consisted of a single trait or if it was multidimensional. Using MTurk, 2173 participants from the United States and the Commonwealth of Nations (in which pornography is not strictly illegal) were recruited and asked to rate how pornographic they thought a list of different depictions were. The data were analyzed utilizing the cross-validation procedure in which two subsamples were created from the main sample and one was used to establish the model building and the other to validate the model. Various models, including first-order and higher-order exploratory and confirmatory factor models, were tested. Results indicated that a bi-factor (multidimensional) model generated the best model fit, and that it was most appropriate to consider pornography multidimensional. The final model contained two dimensions ("Sensitization" and "Differentiation"). While sensitization revealed the participants' general tendency to rate all items to be more or less pornographic, differentiation revealed the participants' tendency to differentiate highly pornographic items from less pornographic items. Based on the findings of this study, we suggest that future research on the usage and effects of pornography be conducted while taking into consideration the multidimensional nature of pornography.

Research on environmental impact of water-based fire extinguishing agents

NASA Astrophysics Data System (ADS)

Wang, Shuai

2018-02-01

This paper offers current status of application of water-based fire extinguishing agents, the environmental and research considerations of the need for the study of toxicity research. This paper also offers systematic review of test methods of toxicity and environmental impact of water-based fire extinguishing agents currently available, illustrate the main requirements and relevant test methods, and offer some research findings for future research considerations. The paper also offers limitations of current study.

Work Group on American Indian Research and Program Evaluation Methodology, Symposium on Research and Evaluation Methodology: Lifespan Issues Related to American Indians/Alaska Natives with Disabilities (Washington, DC, April 26-27, 2002).

ERIC Educational Resources Information Center

Davis, Jamie D., Ed.; Erickson, Jill Shepard, Ed.; Johnson, Sharon R., Ed.; Marshall, Catherine A., Ed.; Running Wolf, Paulette, Ed.; Santiago, Rolando L., Ed.

This first symposium of the Work Group on American Indian Research and Program Evaluation Methodology (AIRPEM) explored American Indian and Alaska Native cultural considerations in relation to "best practices" in research and program evaluation. These cultural considerations include the importance of tribal consultation on research…

Plasma physics and related challenges of millimeter-wave-to-terahertz and high power microwave generationa)

NASA Astrophysics Data System (ADS)

Booske, John H.

2008-05-01

Homeland security and military defense technology considerations have stimulated intense interest in mobile, high power sources of millimeter-wave (mmw) to terahertz (THz) regime electromagnetic radiation, from 0.1 to 10THz. While vacuum electronic sources are a natural choice for high power, the challenges have yet to be completely met for applications including noninvasive sensing of concealed weapons and dangerous agents, high-data-rate communications, high resolution radar, next generation acceleration drivers, and analysis of fluids and condensed matter. The compact size requirements for many of these high frequency sources require miniscule, microfabricated slow wave circuits. This necessitates electron beams with tiny transverse dimensions and potentially very high current densities for adequate gain. Thus, an emerging family of microfabricated, vacuum electronic devices share many of the same plasma physics challenges that are currently confronting "classic" high power microwave (HPM) generators including long-life bright electron beam sources, intense beam transport, parasitic mode excitation, energetic electron interaction with surfaces, and rf air breakdown at output windows. The contemporary plasma physics and other related issues of compact, high power mmw-to-THz sources are compared and contrasted to those of HPM generation, and future research challenges and opportunities are discussed.

Fast and simple high-capacity quantum cryptography with error detection

PubMed Central

Lai, Hong; Luo, Ming-Xing; Pieprzyk, Josef; Zhang, Jun; Pan, Lei; Li, Shudong; Orgun, Mehmet A.

2017-01-01

Quantum cryptography is commonly used to generate fresh secure keys with quantum signal transmission for instant use between two parties. However, research shows that the relatively low key generation rate hinders its practical use where a symmetric cryptography component consumes the shared key. That is, the security of the symmetric cryptography demands frequent rate of key updates, which leads to a higher consumption of the internal one-time-pad communication bandwidth, since it requires the length of the key to be as long as that of the secret. In order to alleviate these issues, we develop a matrix algorithm for fast and simple high-capacity quantum cryptography. Our scheme can achieve secure private communication with fresh keys generated from Fibonacci- and Lucas- valued orbital angular momentum (OAM) states for the seed to construct recursive Fibonacci and Lucas matrices. Moreover, the proposed matrix algorithm for quantum cryptography can ultimately be simplified to matrix multiplication, which is implemented and optimized in modern computers. Most importantly, considerably information capacity can be improved effectively and efficiently by the recursive property of Fibonacci and Lucas matrices, thereby avoiding the restriction of physical conditions, such as the communication bandwidth. PMID:28406240

Fast and simple high-capacity quantum cryptography with error detection.

PubMed

Lai, Hong; Luo, Ming-Xing; Pieprzyk, Josef; Zhang, Jun; Pan, Lei; Li, Shudong; Orgun, Mehmet A

2017-04-13

Quantum cryptography is commonly used to generate fresh secure keys with quantum signal transmission for instant use between two parties. However, research shows that the relatively low key generation rate hinders its practical use where a symmetric cryptography component consumes the shared key. That is, the security of the symmetric cryptography demands frequent rate of key updates, which leads to a higher consumption of the internal one-time-pad communication bandwidth, since it requires the length of the key to be as long as that of the secret. In order to alleviate these issues, we develop a matrix algorithm for fast and simple high-capacity quantum cryptography. Our scheme can achieve secure private communication with fresh keys generated from Fibonacci- and Lucas- valued orbital angular momentum (OAM) states for the seed to construct recursive Fibonacci and Lucas matrices. Moreover, the proposed matrix algorithm for quantum cryptography can ultimately be simplified to matrix multiplication, which is implemented and optimized in modern computers. Most importantly, considerably information capacity can be improved effectively and efficiently by the recursive property of Fibonacci and Lucas matrices, thereby avoiding the restriction of physical conditions, such as the communication bandwidth.

Geophysical potential for wind energy over the open oceans

PubMed Central

2017-01-01

Wind turbines continuously remove kinetic energy from the lower troposphere, thereby reducing the wind speed near hub height. The rate of electricity generation in large wind farms containing multiple wind arrays is, therefore, constrained by the rate of kinetic energy replenishment from the atmosphere above. In recent years, a growing body of research argues that the rate of generated power is limited to around 1.5 W m−2 within large wind farms. However, in this study, we show that considerably higher power generation rates may be sustainable over some open ocean areas. In particular, the North Atlantic is identified as a region where the downward transport of kinetic energy may sustain extraction rates of 6 W m−2 and above over large areas in the annual mean. Furthermore, our results indicate that the surface heat flux from the oceans to the atmosphere may play an important role in creating regions where sustained high rates of downward transport of kinetic energy and thus, high rates of kinetic energy extraction may be geophysical possible. While no commercial-scale deep water wind farms yet exist, our results suggest that such technologies, if they became technically and economically feasible, could potentially provide civilization-scale power. PMID:29073053

Electrocatalysis for oxygen electrodes in fuel cells and water electrolyzers for space applications

NASA Technical Reports Server (NTRS)

Prakash, Jai; Tryk, Donald; Yeager, Ernest

1989-01-01

In most instances separate electrocatalysts are needed to promote the reduction of O2 in the fuel cell mode and to generate O2 in the energy storage-water electrolysis mode in aqueous electrochemical systems operating at low and moderate temperatures (T greater than or equal to 200 C). Interesting exceptions are the lead and bismuth ruthenate pyrochlores in alkaline electrolytes. These catalysts on high area carbon supports have high catalytic activity for both O2 reduction and generation. Rotating ring-disk electrode measurements provide evidence that the O2 reduction proceeds by a parallel four-electron pathway. The ruthenates can also be used as self-supported catalysts to avoid the problems associated with carbon oxidation, but the electrode performance so far achieved in the research at Case Western Reserve University (CWRU) is considerably less. At the potentials involved in the anodic mode the ruthenate pyrochlores have substantial equilibrium solubility in concentrated alkaline electrolyte. This results in the loss of catalyst into the bulk solution and a decline in catalytic activity. Furthermore, the hydrogen generation counter electrode may become contaminated with reduction products from the pyrochlores (lead, ruthenium).

Fast and simple high-capacity quantum cryptography with error detection

NASA Astrophysics Data System (ADS)

Lai, Hong; Luo, Ming-Xing; Pieprzyk, Josef; Zhang, Jun; Pan, Lei; Li, Shudong; Orgun, Mehmet A.

2017-04-01

Quantum cryptography is commonly used to generate fresh secure keys with quantum signal transmission for instant use between two parties. However, research shows that the relatively low key generation rate hinders its practical use where a symmetric cryptography component consumes the shared key. That is, the security of the symmetric cryptography demands frequent rate of key updates, which leads to a higher consumption of the internal one-time-pad communication bandwidth, since it requires the length of the key to be as long as that of the secret. In order to alleviate these issues, we develop a matrix algorithm for fast and simple high-capacity quantum cryptography. Our scheme can achieve secure private communication with fresh keys generated from Fibonacci- and Lucas- valued orbital angular momentum (OAM) states for the seed to construct recursive Fibonacci and Lucas matrices. Moreover, the proposed matrix algorithm for quantum cryptography can ultimately be simplified to matrix multiplication, which is implemented and optimized in modern computers. Most importantly, considerably information capacity can be improved effectively and efficiently by the recursive property of Fibonacci and Lucas matrices, thereby avoiding the restriction of physical conditions, such as the communication bandwidth.

Geophysical potential for wind energy over the open oceans.

PubMed

Possner, Anna; Caldeira, Ken

2017-10-24

Wind turbines continuously remove kinetic energy from the lower troposphere, thereby reducing the wind speed near hub height. The rate of electricity generation in large wind farms containing multiple wind arrays is, therefore, constrained by the rate of kinetic energy replenishment from the atmosphere above. In recent years, a growing body of research argues that the rate of generated power is limited to around 1.5 W m -2 within large wind farms. However, in this study, we show that considerably higher power generation rates may be sustainable over some open ocean areas. In particular, the North Atlantic is identified as a region where the downward transport of kinetic energy may sustain extraction rates of 6 W m -2 and above over large areas in the annual mean. Furthermore, our results indicate that the surface heat flux from the oceans to the atmosphere may play an important role in creating regions where sustained high rates of downward transport of kinetic energy and thus, high rates of kinetic energy extraction may be geophysical possible. While no commercial-scale deep water wind farms yet exist, our results suggest that such technologies, if they became technically and economically feasible, could potentially provide civilization-scale power.

Design, analysis, operation, and advanced control of hybrid renewable energy systems

NASA Astrophysics Data System (ADS)

Whiteman, Zachary S.

Because using non-renewable energy systems (e.g., coal-powered co-generation power plants) to generate electricity is an unsustainable, environmentally hazardous practice, it is important to develop cost-effective and reliable renewable energy systems, such as photovoltaics (PVs), wind turbines (WTs), and fuel cells (FCs). Non-renewable energy systems, however, are currently less expensive than individual renewable energy systems (IRESs). Furthermore, IRESs based on intermittent natural resources (e.g., solar irradiance and wind) are incapable of meeting continuous energy demands. Such shortcomings can be mitigated by judiciously combining two or more complementary IRESs to form a hybrid renewable energy system (HRES). Although previous research efforts focused on the design, operation, and control of HRESs has proven useful, no prior HRES research endeavor has taken a systematic and comprehensive approach towards establishing guidelines by which HRESs should be designed, operated, and controlled. The overall goal of this dissertation, therefore, is to establish the principles governing the design, operation, and control of HRESs resulting in cost-effective and reliable energy solutions for stationary and mobile applications. To achieve this goal, we developed and demonstrated four separate HRES principles. Rational selection of HRES type: HRES components and their sizes should be rationally selected using knowledge of component costs, availability of renewable energy resources, and expected power demands of the application. HRES design: by default, the components of a HRES should be arranged in parallel for increased efficiency and reliability. However, a series HRES design may be preferred depending on the operational considerations of the HRES components. HRES control strategy selection: the choice of HRES control strategy depends on the dynamics of HRES components, their operational considerations, and the practical limitations of the HRES end-use. HRES data-driven control: information-rich data should be used to assist in the intelligent coordination of HRES components in meeting its operating objectives when additional computation can be afforded and significant benefits can be realized.

Fish biorobotics: kinematics and hydrodynamics of self-propulsion.

PubMed

Lauder, George V; Anderson, Erik J; Tangorra, James; Madden, Peter G A

2007-08-01

As a result of years of research on the comparative biomechanics and physiology of moving through water, biologists and engineers have made considerable progress in understanding how animals moving underwater use their muscles to power movement, in describing body and appendage motion during propulsion, and in conducting experimental and computational analyses of fluid movement and attendant forces. But it is clear that substantial future progress in understanding aquatic propulsion will require new lines of attack. Recent years have seen the advent of one such new avenue that promises to greatly broaden the scope of intellectual opportunity available to researchers: the use of biorobotic models. In this paper we discuss, using aquatic propulsion in fishes as our focal example, how using robotic models can lead to new insights in the study of aquatic propulsion. We use two examples: (1) pectoral fin function, and (2) hydrodynamic interactions between dorsal and caudal fins. Pectoral fin function is characterized by considerable deformation of individual fin rays, as well as spanwise (along the length) and chordwise (across the fin) deformation and area change. The pectoral fin can generate thrust on both the outstroke and instroke. A robotic model of the pectoral fin replicates this result, and demonstrates the effect of altering stroke kinematics on the pattern of force production. The soft dorsal fin of fishes sheds a distinct vortex wake that dramatically alters incoming flow to the tail: the dorsal fin and caudal fin act as dual flapping foils in series. This design can be replicated with a dual-foil flapping robotic device that demonstrates this phenomenon and allows examination of regions of the flapping performance space not available to fishes. We show how the robotic flapping foil device can also be used to better understand the significance of flexible propulsive surfaces for locomotor performance. Finally we emphasize the utility of self-propelled robotic devices as a means of understanding how locomotor forces are generated, and review different conceptual designs for robotic models of aquatic propulsion.

Uncovering the wisdom hidden between the lines: the Collaborative Reflexive Deliberative Approach

PubMed Central

Crabtree, Benjamin F; Miller, William L; Gunn, Jane M; Hogg, William E; Scott, Cathie M; Levesque, Jean-Frederic; Harris, Mark F; Chase, Sabrina M; Advocat, Jenny R; Halma, Lisa M; Russell, Grant M

2018-01-01

Abstract Background Meta-analysis and meta-synthesis have been developed to synthesize results across published studies; however, they are still largely grounded in what is already published, missing the tacit ‘between the lines’ knowledge generated during many research projects that are not intrinsic to the main objectives of studies. Objective To develop a novel approach to expand and deepen meta-syntheses using researchers’ experience, tacit knowledge and relevant unpublished materials. Methods We established new collaborations among primary health care researchers from different contexts based on common interests in reforming primary care service delivery and a diversity of perspectives. Over 2 years, the team met face-to-face and via tele- and video-conferences to employ the Collaborative Reflexive Deliberative Approach (CRDA) to discuss and reflect on published and unpublished results from participants’ studies to identify new patterns and insights. Results CRDA focuses on uncovering critical insights, interpretations hidden within multiple research contexts. For the process to work, careful attention must be paid to ensure sufficient diversity among participants while also having people who are able to collaborate effectively. Ensuring there are enough studies for contextual variation also matters. It is necessary to balance rigorous facilitation techniques with the creation of safe space for diverse contributions. Conclusions The CRDA requires large commitments of investigator time, the expense of convening facilitated retreats, considerable coordination, and strong leadership. The process creates an environment where interactions among diverse participants can illuminate hidden information within the contexts of studies, effectively enhancing theory development and generating new research questions and strategies. PMID:29069335

Disease Specific Productivity of American Cancer Hospitals

PubMed Central

Goldstein, Jeffery A.; Prasad, Vinay

2015-01-01

Context Research-oriented cancer hospitals in the United States treat and study patients with a range of diseases. Measures of disease specific research productivity, and comparison to overall productivity, are currently lacking. Hypothesis Different institutions are specialized in research of particular diseases. Objective To report disease specific productivity of American cancer hospitals, and propose a summary measure. Method We conducted a retrospective observational survey of the 50 highest ranked cancer hospitals in the 2013 US News and World Report rankings. We performed an automated search of PubMed and Clinicaltrials.gov for published reports and registrations of clinical trials (respectively) addressing specific cancers between 2008 and 2013. We calculated the summed impact factor for the publications. We generated a summary measure of productivity based on the number of Phase II clinical trials registered and the impact factor of Phase II clinical trials published for each institution and disease pair. We generated rankings based on this summary measure. Results We identified 6076 registered trials and 6516 published trials with a combined impact factor of 44280.4, involving 32 different diseases over the 50 institutions. Using a summary measure based on registered and published clinical trails, we ranked institutions in specific diseases. As expected, different institutions were highly ranked in disease-specific productivity for different diseases. 43 institutions appeared in the top 10 ranks for at least 1 disease (vs 10 in the overall list), while 6 different institutions were ranked number 1 in at least 1 disease (vs 1 in the overall list). Conclusion Research productivity varies considerably among the sample. Overall cancer productivity conceals great variation between diseases. Disease specific rankings identify sites of high academic productivity, which may be of interest to physicians, patients and researchers. PMID:25781329

Disease specific productivity of american cancer hospitals.

PubMed

Goldstein, Jeffery A; Prasad, Vinay

2015-01-01

Research-oriented cancer hospitals in the United States treat and study patients with a range of diseases. Measures of disease specific research productivity, and comparison to overall productivity, are currently lacking. Different institutions are specialized in research of particular diseases. To report disease specific productivity of American cancer hospitals, and propose a summary measure. We conducted a retrospective observational survey of the 50 highest ranked cancer hospitals in the 2013 US News and World Report rankings. We performed an automated search of PubMed and Clinicaltrials.gov for published reports and registrations of clinical trials (respectively) addressing specific cancers between 2008 and 2013. We calculated the summed impact factor for the publications. We generated a summary measure of productivity based on the number of Phase II clinical trials registered and the impact factor of Phase II clinical trials published for each institution and disease pair. We generated rankings based on this summary measure. We identified 6076 registered trials and 6516 published trials with a combined impact factor of 44280.4, involving 32 different diseases over the 50 institutions. Using a summary measure based on registered and published clinical trails, we ranked institutions in specific diseases. As expected, different institutions were highly ranked in disease-specific productivity for different diseases. 43 institutions appeared in the top 10 ranks for at least 1 disease (vs 10 in the overall list), while 6 different institutions were ranked number 1 in at least 1 disease (vs 1 in the overall list). Research productivity varies considerably among the sample. Overall cancer productivity conceals great variation between diseases. Disease specific rankings identify sites of high academic productivity, which may be of interest to physicians, patients and researchers.

Using Digital Technologies in Clinical HIV Research: Real-World Applications and Considerations for Future Work.

PubMed

Andriesen, Jessica; Bull, Sheana; Dietrich, Janan; Haberer, Jessica E; Van Der Pol, Barbara; Voronin, Yegor; Wall, Kristin M; Whalen, Christopher; Priddy, Frances

2017-07-31

Digital technologies, especially if used in novel ways, provide a number of potential advantages to clinical research in trials related to human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) and may greatly facilitate operations as well as data collection and analysis. These technologies may even allow answering questions that are not answerable with older technologies. However, they come with a variety of potential concerns for both the participants and the trial sponsors. The exact challenges and means for alleviation depend on the technology and on the population in which it is deployed, and the rapidly changing landscape of digital technologies presents a challenge for creating future-proof guidelines for technology application. The aim of this study was to identify and summarize some common themes that are frequently encountered by researchers in this context and highlight those that should be carefully considered before making a decision to include these technologies in their research. In April 2016, the Global HIV Vaccine Enterprise surveyed the field for research groups with recent experience in novel applications of digital technologies in HIV clinical research and convened these groups for a 1-day meeting. Real-world uses of various technologies were presented and discussed by 46 attendees, most of whom were researchers involved in the design and conduct of clinical trials of biomedical HIV prevention and treatment approaches. After the meeting, a small group of organizers reviewed the presentations and feedback obtained during the meeting and categorized various lessons-learned to identify common themes. A group of 9 experts developed a draft summary of the findings that was circulated via email to all 46 attendees for review. Taking into account the feedback received, the group finalized the considerations that are presented here. Meeting presenters and attendees discussed the many successful applications of digital technologies to improve research outcomes, such as those for recruitment and enrollment, participant identification, informed consent, data collection, data quality, and protocol or treatment adherence. These discussions also revealed unintended consequence of technology usage, including risks to study participants and risks to study integrity. Key lessons learned from these discussions included the need to thoroughly evaluate systems to be used, the idea that early success may not be sustained throughout the study, that some failures will occur, and considerations for study-provided devices. Additionally, taking these key lessons into account, the group generated recommendations on how to move forward with the use of technology in HIV vaccine and biomedical prevention trials. ©Jessica Andriesen, Sheana Bull, Janan Dietrich, Jessica E Haberer, Barbara Van Der Pol, Yegor Voronin, Kristin M Wall, Christopher Whalen, Frances Priddy. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 31.07.2017.

From Extraction of Local Structures of Protein Energy Landscapes to Improved Decoy Selection in Template-Free Protein Structure Prediction.

PubMed

Akhter, Nasrin; Shehu, Amarda

2018-01-19

Due to the essential role that the three-dimensional conformation of a protein plays in regulating interactions with molecular partners, wet and dry laboratories seek biologically-active conformations of a protein to decode its function. Computational approaches are gaining prominence due to the labor and cost demands of wet laboratory investigations. Template-free methods can now compute thousands of conformations known as decoys, but selecting native conformations from the generated decoys remains challenging. Repeatedly, research has shown that the protein energy functions whose minima are sought in the generation of decoys are unreliable indicators of nativeness. The prevalent approach ignores energy altogether and clusters decoys by conformational similarity. Complementary recent efforts design protein-specific scoring functions or train machine learning models on labeled decoys. In this paper, we show that an informative consideration of energy can be carried out under the energy landscape view. Specifically, we leverage local structures known as basins in the energy landscape probed by a template-free method. We propose and compare various strategies of basin-based decoy selection that we demonstrate are superior to clustering-based strategies. The presented results point to further directions of research for improving decoy selection, including the ability to properly consider the multiplicity of native conformations of proteins.

Global impact of accelerated plant breeding: Evidence from a meta-analysis on rice breeding.

PubMed

Lenaerts, Bert; de Mey, Yann; Demont, Matty

2018-01-01

Rice breeders in Asia and elsewhere in the world have long overlooked trying to shorten the time it takes to develop new varieties. Plant breeders have proposed a technique called Rapid Generation Advance (RGA) as a way to accelerate the results of public rice breeding programs. However, little is known about RGA's potential impact. Here, we present the first results of a global impact study of RGA. More specifically, we calculated the multiplicator effects of RGA on the research benefits generated by conventional rice breeding programs and applied them to a meta-analysis of selected impact studies in the literature. These insights are a first crucial step in developing a targeted approach for disseminating RGA technology among rice breeders to accelerate the impact of their public rice breeding programs around the world. We show that the additional benefits due to time savings are considerable and offer some insights into the economics of breeding. Our results confirm that the adoption of accelerated breeding would lead to substantial advantages to rice breeding programs and the earlier variety release leads to significant economic benefits to society. This can be important to policy makers when reshaping their public breeding methods and optimising their return on research investments in breeding.

Consumer language, patient language, and thesauri: a review of the literature

PubMed Central

Smith, Catherine A

2011-01-01

Objective: Online social networking sites are web services in which users create public or semipublic profiles and connect to build online communities, finding likeminded people through self-labeled personal attributes including ethnicity, leisure interests, political beliefs, and, increasingly, health status. Thirty-nine percent of patients in the United States identified themselves as users of social networks in a recent survey. “Tags,” user-generated descriptors functioning as labels for user-generated content, are increasingly important to social networking, and the language used by patients is thus becoming important for knowledge representation in these systems. However, patient language poses considerable challenges for health communication and networking. How have information systems traditionally incorporated these languages in their controlled vocabularies and thesauri? How do system builders know what consumers and patients say? Methods: This comprehensive review of the literature of health care (PubMed MEDLINE, CINAHL), library science, and information science (Library and Information Science and Technology Abstracts, Library and Information Science Abstracts, and Library Literature) examines the research domains in which consumer and patient language has been explored. Results: Consumer contributions to controlled vocabulary appear to be seriously under-researched inside and outside of health care. Conclusion: The author reflects on the implications of these findings for online social networks devoted to patients and the patient experience. PMID:21464851

Consumer language, patient language, and thesauri: a review of the literature.

PubMed

Smith, Catherine A

2011-04-01

Online social networking sites are web services in which users create public or semipublic profiles and connect to build online communities, finding like-minded people through self-labeled personal attributes including ethnicity, leisure interests, political beliefs, and, increasingly, health status. Thirty-nine percent of patients in the United States identified themselves as users of social networks in a recent survey. "Tags," user-generated descriptors functioning as labels for user-generated content, are increasingly important to social networking, and the language used by patients is thus becoming important for knowledge representation in these systems. However, patient language poses considerable challenges for health communication and networking. How have information systems traditionally incorporated these languages in their controlled vocabularies and thesauri? How do system builders know what consumers and patients say? This comprehensive review of the literature of health care (PubMed MEDLINE, CINAHL), library science, and information science (Library and Information Science and Technology Abstracts, Library and Information Science Abstracts, and Library Literature) examines the research domains in which consumer and patient language has been explored. Consumer contributions to controlled vocabulary appear to be seriously under-researched inside and outside of health care. The author reflects on the implications of these findings for online social networks devoted to patients and the patient experience.

Numerical Optimization Strategy for Determining 3D Flow Fields in Microfluidics

NASA Astrophysics Data System (ADS)

Eden, Alex; Sigurdson, Marin; Mezic, Igor; Meinhart, Carl

2015-11-01

We present a hybrid experimental-numerical method for generating 3D flow fields from 2D PIV experimental data. An optimization algorithm is applied to a theory-based simulation of an alternating current electrothermal (ACET) micromixer in conjunction with 2D PIV data to generate an improved representation of 3D steady state flow conditions. These results can be used to investigate mixing phenomena. Experimental conditions were simulated using COMSOL Multiphysics to solve the temperature and velocity fields, as well as the quasi-static electric fields. The governing equations were based on a theoretical model for ac electrothermal flows. A Nelder-Mead optimization algorithm was used to achieve a better fit by minimizing the error between 2D PIV experimental velocity data and numerical simulation results at the measurement plane. By applying this hybrid method, the normalized RMS velocity error between the simulation and experimental results was reduced by more than an order of magnitude. The optimization algorithm altered 3D fluid circulation patterns considerably, providing a more accurate representation of the 3D experimental flow field. This method can be generalized to a wide variety of flow problems. This research was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office.

Gravity Effects in Microgap Flow Boiling

NASA Technical Reports Server (NTRS)

Robinson, Franklin; Bar-Cohen, Avram

2017-01-01

Increasing integration density of electronic components has exacerbated the thermal management challenges facing electronic system developers. The high power, heat flux, and volumetric heat generation of emerging devices are driving the transition from remote cooling, which relies on conduction and spreading, to embedded cooling, which facilitates direct contact between the heat-generating device and coolant flow. Microgap coolers employ the forced flow of dielectric fluids undergoing phase change in a heated channel between devices. While two phase microcoolers are used routinely in ground-based systems, the lack of acceptable models and correlations for microgravity operation has limited their use for spacecraft thermal management. Previous research has revealed that gravitational acceleration plays a diminishing role as the channel diameter shrinks, but there is considerable variation among the proposed gravity-insensitive channel dimensions and minimal research on rectangular ducts. Reliable criteria for achieving gravity-insensitive flow boiling performance would enable spaceflight systems to exploit this powerful thermal management technique and reduce development time and costs through reliance on ground-based testing. In the present effort, the authors have studied the effect of evaporator orientation on flow boiling performance of HFE7100 in a 218 m tall by 13.0 mm wide microgap cooler. Similar heat transfer coefficients and critical heat flux were achieved across five evaporator orientations, indicating that the effect of gravity was negligible.

Methane producing bacteria: Immunological characterization: Progress report, April 1, 1984--June 30, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conway de Macario, E.; Macario, A.J.L.; Wolin, M.J.

1988-01-01

A major contribution of this research has been a significant advance of the immunology of methanogens and other archaebacteria (e.g., extreme halophiles). The foundations have been laid to begin the immunologic study of microbes which are non-methanogens themselves but are important for the fermentation process. This work helped to make clear that bacterial immunology goes beyond the study of pathogens for man, animals, or plants. Immunology can be applied successfully to the study of isolates of importance to understand evolution, phylogeny, ecology, bio-conversion systems, and to advance methanogenic biotechnology. Immunology holds considerable potential to aid in genetic and genetic engineeringmore » manipulations as well as in in situ handling of microbes relevant to methanogenesis. Thus, antibodies can help in the discovery of useful microbes, the generation of improved stains, the selection of desirable microorganisms, and in the monitoring and controlling of bioreactors. Immunogolic work in this new field should generate knowledge and devices relevant to areas such as Biological Energy Research, Ecology of Microorganisms, and Environmental (Sanitary) Engineering. In this regard, this work has contributed a comprehensive antiserum bank, a large panel of calibrated polyclonal antibody probes, and techniques for producing and utilizing these probes in the study of methanogens and related bacteria. 67 refs.« less

Creating Robust STEM Research Ecosystems in Schools: Joining the Dots for Young Researchers

NASA Astrophysics Data System (ADS)

Pritchard, M.; Ibarra, D. L.

2017-12-01

Developing an intelligent curiosity about the world in school-aged learners is one of the key purposes of education. Nurturing this intelligent curiosity in a systematic and integrated manner is essential for rigorous, scientific literacy, which in turn inspires advanced research and innovation in post-school life. STEM (Science, Technology, Engineering, and Mathematics) education has been widely adopted as the conceptual framework to achieve this goal. For young learners, their experienced world is largely confined to the spaces within the boundaries of educational institutions. This type of environment might be perceived as sterile or even hostile to genuine research, as institutional endeavor is largely shaped by examination syllabi. This can be changed by viewing the school as a living laboratory of processes and products, all of which offer enormous potential for meaningful and valuable student-led STEM research. Creating research-focused ecosystems within schools, however, requires considerable effort to create a learning culture that defragments knowledge systems and connects isolated pools of inquiry. The existing parameters and processes of school ecosystems, such as energy generation, consumption, waste creation and disposal offer opportunities for school students to utilize STEM-related skills observe and measure their own ecological footprint, undertake research into these living processes in an integrated manner, and develop solutions to create closed loops of optimally managed and measured consumption with the institution. For example, connecting a deep understanding of the principles of renewable energy generation with close, real-time monitoring of classroom energy usage creates the opportunity to develop a higher level of user awareness and more optimized consumption habits. Food waste, when composted and recycled on-site, similarly offers the potential to connect the sociological issue of excess consumption with a scientific understanding of aerobic and anaerobic decomposition and the subsequent purposes to which the product of the process might be put. In adopting a STEM framework to examine and shape school ecosystems, young researchers develop the capacity to observe, measure, analyze, troubleshoot, and optimize their own environment.

Corporate Proprietary Data vs. Thesis Publication, an Exercise in Diplomacy.

ERIC Educational Resources Information Center

Stein, Alan

1987-01-01

The tripling of corporate money in research support at Colorado School of Mines has had a considerable impact on contractual considerations. Governmental agencies normally encourage publication of research while private corporations discourage same. Negotiation processes with companies are discussed. (MLW)

78 FR 10001 - Proposed Collection; Comment Request for Form 706-GS(D)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-12

... Form 706-GS(D), Generation-Skipping Transfer Tax Return for Distributions. DATES: Written comments should be received on or before April 15, 2013 to be assured of consideration. ADDRESSES: Direct all... [email protected] . SUPPLEMENTARY INFORMATION: Title: Generation-Skipping Transfer Tax Return for...

Generative Perspectives on Language Acquisition: Empirical Findings, Theoretical Considerations, and Crosslinguistic Comparisons.

ERIC Educational Resources Information Center

Clahsen, Harald, Ed.

The collection of essays and studies concerning generative grammar and first and second language acquisition includes: "The Optional-Infinitive Stage in Child English: Evidence from Negation" (Tony Harris, Ken Wexler); "Towards a Structure-Building Model of Acquisition" (Andrew Radford); "The Underspecification of…

An Internationally Comparative Study of Immigration and Adolescent Emotional and Behavioral Problems: Effects of Generation and Gender.

PubMed

Stevens, Gonneke W J M; Walsh, Sophie D; Huijts, Tim; Maes, Marlies; Madsen, Katrine Rich; Cavallo, Franco; Molcho, Michal

2015-12-01

Although the potential consequences of immigration for adolescent problem behaviors have been addressed in many former studies, internationally comparative research is scarce. This study investigated the impact of immigration on four indicators of adolescents' emotional and behavioral problems in 10 countries, taking into account gender and immigrant generation as moderating factors. Analyses were based on data from 11-, 13-, and 15-year-old adolescents participating in the Health Behavior in School-aged Children study in Denmark, Germany, Greece, Iceland, Ireland, Italy, the Netherlands, Spain, the United States, and Wales (total N = 53,218). Both first- and second-generation immigrant adolescents reported higher levels of physical fighting and bullying and a lower life satisfaction than native adolescents, whereas second-generation immigrant adolescents reported more psychosomatic symptoms than native adolescents. Effect sizes varied considerable for the different outcomes, and similar effects were found for first- and second-generation immigrant adolescents. Differences in these indicators of emotional and behavioral problems between immigrant and native adolescents did not vary significantly with the receiving country. With two exceptions, effects of immigrant status were similar for boys and girls. Although no differences in psychosomatic symptoms were found between first-generation immigrant and native girls, first-generation immigrant boys reported less psychosomatic symptoms than native boys. Furthermore, both second-generation immigrant boys and girls reported higher levels of physical fighting than their native peers, but differences were more pronounced for boys than for girls. Overall, the results of this study support a risk perspective on the impact of immigration on adolescent problem behaviors. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Perspectives in flow-based microfluidic gradient generators for characterizing bacterial chemotaxis

PubMed Central

Wolfram, Christopher J.; Rubloff, Gary W.; Luo, Xiaolong

2016-01-01

Chemotaxis is a phenomenon which enables cells to sense concentrations of certain chemical species in their microenvironment and move towards chemically favorable regions. Recent advances in microbiology have engineered the chemotactic properties of bacteria to perform novel functions, but traditional methods of characterizing chemotaxis do not fully capture the associated cell motion, making it difficult to infer mechanisms that link the motion to the microbiology which induces it. Microfluidics offers a potential solution in the form of gradient generators. Many of the gradient generators studied to date for this application are flow-based, where a chemical species diffuses across the laminar flow interface between two solutions moving through a microchannel. Despite significant research efforts, flow-based gradient generators have achieved mixed success at accurately capturing the highly subtle chemotactic responses exhibited by bacteria. Here we present an analysis encompassing previously published versions of flow-based gradient generators, the theories that govern their gradient-generating properties, and new, more practical considerations that result from experimental factors. We conclude that flow-based gradient generators present a challenge inherent to their design in that the residence time and gradient decay must be finely balanced, and that this significantly narrows the window for reliable observation and quantification of chemotactic motion. This challenge is compounded by the effects of shear on an ellipsoidal bacterium that causes it to preferentially align with the direction of flow and subsequently suppresses the cross-flow chemotactic response. These problems suggest that a static, non-flowing gradient generator may be a more suitable platform for chemotaxis studies in the long run, despite posing greater difficulties in design and fabrication. PMID:27917249

Perspectives in flow-based microfluidic gradient generators for characterizing bacterial chemotaxis.

PubMed

Wolfram, Christopher J; Rubloff, Gary W; Luo, Xiaolong

2016-11-01

Chemotaxis is a phenomenon which enables cells to sense concentrations of certain chemical species in their microenvironment and move towards chemically favorable regions. Recent advances in microbiology have engineered the chemotactic properties of bacteria to perform novel functions, but traditional methods of characterizing chemotaxis do not fully capture the associated cell motion, making it difficult to infer mechanisms that link the motion to the microbiology which induces it. Microfluidics offers a potential solution in the form of gradient generators. Many of the gradient generators studied to date for this application are flow-based, where a chemical species diffuses across the laminar flow interface between two solutions moving through a microchannel. Despite significant research efforts, flow-based gradient generators have achieved mixed success at accurately capturing the highly subtle chemotactic responses exhibited by bacteria. Here we present an analysis encompassing previously published versions of flow-based gradient generators, the theories that govern their gradient-generating properties, and new, more practical considerations that result from experimental factors. We conclude that flow-based gradient generators present a challenge inherent to their design in that the residence time and gradient decay must be finely balanced, and that this significantly narrows the window for reliable observation and quantification of chemotactic motion. This challenge is compounded by the effects of shear on an ellipsoidal bacterium that causes it to preferentially align with the direction of flow and subsequently suppresses the cross-flow chemotactic response. These problems suggest that a static, non-flowing gradient generator may be a more suitable platform for chemotaxis studies in the long run, despite posing greater difficulties in design and fabrication.

Challenges in diabetology research in India.

PubMed

Jena, Swarup; Mishra, Brijesh; Yadav, Anamika; Desai, Pranav

2018-05-01

Diabetes emerges out to be a major epidemic in recent years that engulfs both developed and developing countries across the globe. India, a country witnessing rapid socioeconomic progress and urbanization carries a considerable share of the global diabetes burden. There has been an incongruity between disease burden and the technical capacity to make use of existing knowledge or to generate new knowledge to combat diabetes in India. This paper examines the role of different actors, organizations & institutions in shaping diabetology research in India using arrays of scientific indicators such as research output (publications and patents), research finance and role of policy-making bodies. This paper also identifies research gaps and challenges pertinent to this sector. A combination of three methods patent data analysis, publication data analysis and primary survey corroborated with secondary data to obtain desire objectives. We made an in-depth study of the patent and publication data (2000-2016) to know the research output and direction of Indian actors, institutions and organizations in the area of diabetes research. This paper identifies some key structural barriers and institutional challenges pertinent to diabetology research in India that will help in canvassing and formulating science, technology and policy guidelines for diabetology research in India CONCLUSION: Multilevel intervention requires bridging the gap between knowledge and action hence policy-making should align to balance resources with innovation capabilities. Copyright © 2017 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Regulations and Ethical Considerations for Astronomy Education Research III: A Suggested Code of Ethics

NASA Astrophysics Data System (ADS)

Brogt, Erik; Foster, Tom; Dokter, Erin; Buxner, Sanlyn; Antonellis, Jessie

We present an argument for, and suggested implementation of, a code of ethics for the astronomy education research community. This code of ethics is based on legal and ethical considerations set forth by U.S. federal regulations and the existing code of conduct of the American Educational Research Association. We also provide a fictitious research study as an example for working through the suggested code of ethics.

Knowledge translation within a population health study: how do you do it?

PubMed Central

2013-01-01

Background Despite the considerable and growing body of knowledge translation (KT) literature, there are few methodologies sufficiently detailed to guide an integrated KT research approach for a population health study. This paper argues for a clearly articulated collaborative KT approach to be embedded within the research design from the outset. Discussion Population health studies are complex in their own right, and strategies to engage the local community in adopting new interventions are often fraught with considerable challenges. In order to maximise the impact of population health research, more explicit KT strategies need to be developed from the outset. We present four propositions, arising from our work in developing a KT framework for a population health study. These cover the need for an explicit theory-informed conceptual framework; formalizing collaborative approaches within the design; making explicit the roles of both the stakeholders and the researchers; and clarifying what counts as evidence. From our deliberations on these propositions, our own co-creating (co-KT) Framework emerged in which KT is defined as both a theoretical and practical framework for actioning the intent of researchers and communities to co-create, refine, implement and evaluate the impact of new knowledge that is sensitive to the context (values, norms and tacit knowledge) where it is generated and used. The co-KT Framework has five steps. These include initial contact and framing the issue; refining and testing knowledge; interpreting, contextualising and adapting knowledge to the local context; implementing and evaluating; and finally, the embedding and translating of new knowledge into practice. Summary Although descriptions of how to incorporate KT into research designs are increasing, current theoretical and operational frameworks do not generally span a holistic process from knowledge co-creation to knowledge application and implementation within one project. Population health studies may have greater health impact when KT is incorporated early and explicitly into the research design. This, we argue, will require that particular attention be paid to collaborative approaches, stakeholder identification and engagement, the nature and sources of evidence used, and the role of the research team working with the local study community. PMID:23694753

Raising the Bar for Reproducible Science at the US Environmental Protection Agency Office of Research and Development

EPA Science Inventory

Considerable concern has been raised regarding research reproducibility both within and outside the scientific community. Several factors possibly contribute to a lack of reproducibility, including a failure to adequately employ statistical considerations during study design, bia...

Using mixed methods effectively in prevention science: designs, procedures, and examples.

PubMed

Zhang, Wanqing; Watanabe-Galloway, Shinobu

2014-10-01

There is growing interest in using a combination of quantitative and qualitative methods to generate evidence about the effectiveness of health prevention, services, and intervention programs. With the emerging importance of mixed methods research across the social and health sciences, there has been an increased recognition of the value of using mixed methods for addressing research questions in different disciplines. We illustrate the mixed methods approach in prevention research, showing design procedures used in several published research articles. In this paper, we focused on two commonly used mixed methods designs: concurrent and sequential mixed methods designs. We discuss the types of mixed methods designs, the reasons for, and advantages of using a particular type of design, and the procedures of qualitative and quantitative data collection and integration. The studies reviewed in this paper show that the essence of qualitative research is to explore complex dynamic phenomena in prevention science, and the advantage of using mixed methods is that quantitative data can yield generalizable results and qualitative data can provide extensive insights. However, the emphasis of methodological rigor in a mixed methods application also requires considerable expertise in both qualitative and quantitative methods. Besides the necessary skills and effective interdisciplinary collaboration, this combined approach also requires an open-mindedness and reflection from the involved researchers.

Teasing apart the relations between age, birth cohort, and vocational interests.

PubMed

Leuty, Melanie E; Hansen, Jo-Ida C

2014-04-01

Empirical evidence supports that aging is related to differences in work attitudes and motivation (Inceoglu, Segers, & Bartram, 2012; Kooij, de Lange, Jansen, Kanfer, & Kikkers, 2011; Ng & Feldman, 2008, 2010), but little research has explored the relations between age and vocational interests. Furthermore, recent studies of age and work attitudes suggest that generational experiences (i.e., birth year) may account for age differences in the workplace (Inceoglu et al., 2012; Ng & Feldman, 2008, 2010), which in turn suggests that researchers need to incorporate both age and birth cohort effects in their designs. Thus, this study was designed to explore the relations of age at the time of testing and birth year to vocational interests using a sample of adults (N = 1,792) collected over a period of 3 decades. As expected, age was not a significant predictor of most interests, but birth year also was not found to predict most interests, with the significant prediction of Realistic interests by both age and birth year being the exception. Gender, however, significantly predicted most areas of interests. Neither age nor gender moderated any relationships between birth year and interests. Results suggest that birth year and age were minimally related to interests as all effect sizes were small. Discussion of the results illustrates the need for further research on this issue and also offers considerations for attracting and retaining different generations of workers in light of the findings. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

Principles for research on ethnicity and health: the Leeds Consensus Statement.

PubMed

Mir, Ghazala; Salway, Sarah; Kai, Joe; Karlsen, Saffron; Bhopal, Raj; Ellison, George Th; Sheikh, Aziz

2013-06-01

There is substantial evidence that health and health-care experiences vary along ethnic lines and the need to understand and tackle ethnic health inequalities has repeatedly been highlighted. Research into ethnicity and health raises ethical, theoretical and methodological issues and, as the volume of research in this area grows, so too do concerns regarding its scientific rigour and reporting, and its contribution to reducing inequalities. Guidance may be helpful in encouraging researchers to adopt standard practices in the design, conduct and reporting of research. However, past efforts at introducing such guidance have had limited impact on research practice, and the diversity of disciplinary perspectives on the key challenges and solutions may undermine attempts to derive and promote guiding principles. A consensus building Delphi exercise--the first of its kind in this area of research practice--was undertaken with leading academics, practitioners and policymakers from a broad range of disciplinary backgrounds to assess whether consensus on key principles could be achieved. Ten key principles for conducting research on ethnicity and health emerged, covering: the aims of research in this field; how such research should be framed and focused; key design-related considerations; and the direction of future research. Despite some areas of dispute, participants were united by a common concern that the generation and application of research evidence should contribute to better health-care experiences and health outcomes for minority ethnic people. The principles provide a strong foundation to guide future ethnicity-related research and build a broader international consensus.

75 FR 38869 - Proposed Collection; Comment Request for Regulation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

...-73-88 (TD 8644), Generation-Skipping Transfer Tax (Sec. Sec. 26.2601-1, 26.2632- 1, 26.2642-1, 26... or before September 7, 2010 to be assured of consideration. ADDRESSES: Direct all written comments to... [email protected] . SUPPLEMENTARY INFORMATION: Title: Generation-Skipping Transfer Tax. OMB...

Influencing the Future: Special Considerations for IPY Education and Outreach

NASA Astrophysics Data System (ADS)

Beitler, J.

2004-12-01

The International Geophysical Year (IGY) of 1957-1958 created a valuable legacy, by not only advancing the sciences involved, but by also stimulating interest in and support for science, and by inspiring many to enter science careers. Successful education and outreach efforts in conjunction with IGY transmitted this energy to the public and helped researchers to create this legacy. The International Polar Year (IPY) for 2007-2008 again holds promise to generate new scientific insights and leave a similar legacy -- if the sciences are once again successful in connecting with the public. Despite the fine example of the IGY of 1958 -1959, the way forward for meaningful education and outreach for IPY isn't entirely clear. Every element affecting science education and outreach today is considerably more complex, and the distinct challenges and opportunities of today may not always be addressed by simply extending what has been helpful in the past. Whether a large research group or an individual researcher, whether working with a dedicated outreach staff or conducting outreach more informally, whether already operating successful outreach programs or starting from scratch, any project intending an education and outreach effort will significantly increase its relevance and effectiveness by taking pause to formulate specific goals and objectives for IPY. Such thinking shouldn't be entirely delegated to non-researchers. The engagement of the scientists themselves in setting objectives for education and outreach will provide the strongest outcome. This discussion analyzes the communication setting for IPY as it affects outreach and education efforts, and proposes a model for discussing and formulating outreach and education objectives. It poses the key questions that should be asked and answered in order to ensure that researchers take full advantage of education and outreach opportunities with IPY, whatever the scope of their efforts. Education and outreach programs that are thus informed by thoughtful objective-setting will have the best chance to be a valuable investment in the future of science and society.

Environmental reporting and accounting in Australia: progress, prospects and research priorities.

PubMed

van Dijk, Albert; Mount, Richard; Gibbons, Philip; Vardon, Michael; Canadell, Pep

2014-03-01

Despite strong demand for information to support the sustainable use of Australia's natural resources and conserve environmental values and despite considerable effort and investment, nation-wide environmental data collection and analysis remains a substantially unmet challenge. We review progress in producing national environmental reports and accounts, identify challenges and opportunities, and analyse the potential role of research in addressing these. Australia's low and concentrated population density and the short history since European settlement contribute to the lack of environmental data. There are additional factors: highly diverse data requirements and standards, disagreement on information priorities, poorly measurable management objectives, lack of coordination, over-reliance on researchers and businesses for data collection, lack of business engagement, and short-term, project-based activities. New opportunities have arisen to overcome some of these challenges: enhanced monitoring networks, standardisation, data management and modelling, greater commitment to share and integrate data, community monitoring, increasing acceptance of environmental and sustainability indicators, and progress in environmental accounting practices. Successes in generating climate, water and greenhouse gas information appear to be attributable to an unambiguous data requirement, considerable investment, and legislative instruments that enhance data sharing and create a clearly defined role for operational agencies. Based on the analysis presented, we suggest six priorities for research: (1) common definitions and standards for information that address management objectives, (2) ecological measures that are scalable from local to national level, (3) promotion of long-term data collection and reporting by researchers, (4) efficient satellite and sensor network technologies and data analysis methods, (5) environmental modelling approaches that can reconcile multiple data sources, and (6) experimental accounting to pursue consistent, credible and relevant information structures and to identify new data requirements. Opportunities exist to make progress in each of these areas and help secure a more sustainable future. Copyright © 2014. Published by Elsevier B.V.

76 FR 26771 - Florida Power & Light Company; Turkey Point, Units 3 and 4; Notice of Consideration of Issuance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-09

... Company; Turkey Point, Units 3 and 4; Notice of Consideration of Issuance of Amendment to Facility... issued to Florida Power & Light Co. (the licensee) for operation of the Turkey Point Nuclear Generating... licensed core power level for Turkey Point, Units 3 and 4, from 2300 megawatts thermal (MWt) to 2644 MWt...

Design of a Blended Learning Environment: Considerations and Implementation Issues

ERIC Educational Resources Information Center

Gedik, Nuray; Kiraz, Ercan; Ozden, M. Yasar

2013-01-01

This study identified critical issues in the design of a blended learning environment by examining basic design considerations and implementation issues. Following a design-based research approach with the phenomenological tradition of qualitative research, the study investigated instructor experiences relating to the design, development, and…

Multiple-generator errors are unavoidable under model misspecification.

PubMed

Jewett, D L; Zhang, Z

1995-08-01

Model misspecification poses a major problem for dipole source localization (DSL) because it causes insidious multiple-generator errors (MulGenErrs) to occur in the fitted dipole parameters. This paper describes how and why this occurs, based upon simple algebraic considerations. MulGenErrs must occur, to some degree, in any DSL analysis of real data because there is model misspecification and mathematically the equations used for the simultaneously active generators must be of a different form than the equations for each generator active alone.

Approaches to the automatic generation and control of finite element meshes

NASA Technical Reports Server (NTRS)

Shephard, Mark S.

1987-01-01

The algorithmic approaches being taken to the development of finite element mesh generators capable of automatically discretizing general domains without the need for user intervention are discussed. It is demonstrated that because of the modeling demands placed on a automatic mesh generator, all the approaches taken to date produce unstructured meshes. Consideration is also given to both a priori and a posteriori mesh control devices for automatic mesh generators as well as their integration with geometric modeling and adaptive analysis procedures.

The impact of knowledge sharing through social media among academia

NASA Astrophysics Data System (ADS)

Ghazali, Saadiah; Sulaiman, Nor Intan Saniah; Zabidi, Nerda Zura; Omar, Mohd Faizal; Alias, Rose Alinda

2016-10-01

The world of research require researcher, academia and lecturers to share knowledge among them. With the invention of social media, knowledge sharing process has been more effective and easy. Previously, there were numerous researches done to investigate the effect of social media utilization for public used. There were also study that aimed to study social media effects in educatioanal sector but those study were centered around student's perspective. Less consideration is given towards academia's perspective. Therefore, this study is directed to explore other niche area on knowledge sharing environment where it will focused on the effects of social media on knowledge sharing among academia. Initially, literature review analysis was done to discover the potential factors that encourage academia to engage in social media. Ability to facilitate communication, idea generation and group establishment are the most cited reasons. Not only that, this paper will highlight the significance of performing this study. In conclusion, there is no doubt that social media do enhance and upgrading the knowledge sharing process thus assisting academia in their scholarly work.

Distance art groups for women with breast cancer: guidelines and recommendations.

PubMed

Collie, Kate; Bottorff, Joan L; Long, Bonita C; Conati, Cristina

2006-08-01

To overcome barriers that prevent women with breast cancer from attending support groups, innovative formats and modes of delivery both need to be considered. The present study was part of an interdisciplinary program of research in which researchers from counseling psychology, psycho-oncology, nursing, computer science, and fine arts have explored art making as an innovative format and telehealth as a mode of delivery. For this study, we conducted focus groups and interviews with 25 people with expertise about breast cancer, art, art therapy, and distance delivery of mental health services to generate guidelines for distance art-based psychosocial support services to women with breast cancer. A qualitative analysis of the focus group and interview data yielded guidelines for developers and facilitators of distance art groups for women with breast cancer pertaining to (a) emotional expression, (b) emotional support, (c) emotional safety, and (d) accommodating individual differences, plus special considerations for art therapy groups. Further research is needed pertaining to the use of computers, involvement of art therapists, and screening out vulnerable clients.

Biomolecule-embedded metal-organic frameworks as an innovative sensing platform.

PubMed

Kempahanumakkagari, Sureshkumar; Kumar, Vanish; Samaddar, Pallabi; Kumar, Pawan; Ramakrishnappa, Thippeswamy; Kim, Ki-Hyun

Technological advancements combined with materials research have led to the generation of enormous types of novel substrates and materials for use in various biological/medical, energy, and environmental applications. Lately, the embedding of biomolecules in novel and/or advanced materials (e.g., metal-organic frameworks (MOFs), nanoparticles, hydrogels, graphene, and their hybrid composites) has become a vital research area in the construction of an innovative platform for various applications including sensors (or biosensors), biofuel cells, and bioelectronic devices. Due to the intriguing properties of MOFs (e.g., framework architecture, topology, and optical properties), they have contributed considerably to recent progresses in enzymatic catalysis, antibody-antigen interactions, or many other related approaches. Here, we aim to describe the different strategies for the design and synthesis of diverse biomolecule-embedded MOFs for various sensing (e.g., optical, electrochemical, biological, and miscellaneous) techniques. Additionally, the benefits and future prospective of MOFs-based biomolecular immobilization as an innovative sensing platform are discussed along with the evaluation on their performance to seek for further development in this emerging research area. Copyright © 2018. Published by Elsevier Inc.

Neuroanatomical abnormalities in chronic tinnitus in the human brain

PubMed Central

Adjamian, Peyman; Hall, Deborah A.; Palmer, Alan R.; Allan, Thomas W.; Langers, Dave R.M.

2014-01-01

In this paper, we review studies that have investigated brain morphology in chronic tinnitus in order to better understand the underlying pathophysiology of the disorder. Current consensus is that tinnitus is a disorder involving a distributed network of peripheral and central pathways in the nervous system. However, the precise mechanism remains elusive and it is unclear which structures are involved. Given that brain structure and function are highly related, identification of anatomical differences may shed light upon the mechanism of tinnitus generation and maintenance. We discuss anatomical changes in the auditory cortex, the limbic system, and prefrontal cortex, among others. Specifically, we discuss the gating mechanism of tinnitus and evaluate the evidence in support of the model from studies of brain anatomy. Although individual studies claim significant effects related to tinnitus, outcomes are divergent and even contradictory across studies. Moreover, results are often confounded by the presence of hearing loss. We conclude that, at present, the overall evidence for structural abnormalities specifically related to tinnitus is poor. As this area of research is expanding, we identify some key considerations for research design and propose strategies for future research. PMID:24892904

`Brown Paper Packages'? A Sociocultural Perspective on Young Children's Ideas in Science

NASA Astrophysics Data System (ADS)

Robbins, Jill

2005-09-01

How do we see young children's thinking in science? Is it, as much previous research has led us to believe, that their ideas can be neatly boxed like “brown paper packages tied up with strings” - as the song from The Sound of Music goes? Or are their ideas like “wild geese that fly with the moon on their wings” ( Sound of Music): fluid, complex, rich. . .? Drawing on the author's research into young children's ideas about natural phenomena such as the rain and clouds, and on Rogoff's three foci of analysis (personal, interpersonal and contextual), this paper illustrates how a consideration of sociocultural theory can be useful in framing research with young children, and allow us to see beyond the boxes. Emphasis is placed on recognising that children's thinking in science is embedded within particular sociocultural contexts, is guided by others and integrated with their use of certain mental and physical cultural tools. Thus, the article aims to present an alternative method for the generation of data on young children's thinking. Specific analysis of this data will, it is intended, be presented in a subsequent article.