Are Young Generations in Secondary School Digitally Competent? A Study on Italian Teenagers

ERIC Educational Resources Information Center

Calvani, Aomina; Fini, Antonio; Ranieri, Maria; Picci, Patrizia

2012-01-01

Digital competences amongst the younger generations and the role of schools faced with the spread of new youth practices are topics of increasing interest. Some commentators state that, thanks to the intensive use of digital media, young people are developing significant competences that also correspond to important cognitive processes and new…

Gas-pressure dependence of terahertz-pulse generation in a laser-generated nitrogen plasma

NASA Astrophysics Data System (ADS)

Löffler, T.; Roskos, H. G.

2002-03-01

Far-infrared (terahertz) pulses can be generated by photoionization of electrically biased gases with amplified laser pulses [T. Löffler, F. Jacob, and H. G. Roskos, Appl. Phys. Lett. 77, 453 (2000)]. The efficiency of the generation process can be significantly increased when the absolute gas pressure is raised because it is then possible to apply higher bias fields close to the dielectric breakdown field of the gas which increases with the pressure. The dependence of the THz output on the optical pump power does not show any indication of saturation, making the plasma emitter an interesting source for THz pulses especially in conjunction with terawatt laser systems.

Hardwood timber supplies in the United States

Treesearch

William A. Bechtold; Raymond M. Sheffield

1991-01-01

Long recognized for their wildlife, watershed, and aesthetic value, hardwoods are becoming increasingly important from the standpoint of timber production. The abundance of hardwood inventory volume, technological advances allowing greater substitution into softwood markets, and relatively low stumpage prices have generated a growing interest in increased utilization...

Increasing Valid Profiles in Phallometric Assessment of Sex Offenders with Child Victims: Combining the Strengths of Audio Stimuli and Synthetic Characters.

PubMed

Marschall-Lévesque, Shawn; Rouleau, Joanne-Lucine; Renaud, Patrice

2018-02-01

Penile plethysmography (PPG) is a measure of sexual interests that relies heavily on the stimuli it uses to generate valid results. Ethical considerations surrounding the use of real images in PPG have further limited the content admissible for these stimuli. To palliate this limitation, the current study aimed to combine audio and visual stimuli by incorporating computer-generated characters to create new stimuli capable of accurately classifying sex offenders with child victims, while also increasing the number of valid profiles. Three modalities (audio, visual, and audiovisual) were compared using two groups (15 sex offenders with child victims and 15 non-offenders). Both the new visual and audiovisual stimuli resulted in a 13% increase in the number of valid profiles at 2.5 mm, when compared to the standard audio stimuli. Furthermore, the new audiovisual stimuli generated a 34% increase in penile responses. All three modalities were able to discriminate between the two groups by their responses to the adult and child stimuli. Lastly, sexual interest indices for all three modalities could accurately classify participants in their appropriate groups, as demonstrated by ROC curve analysis (i.e., audio AUC = .81, 95% CI [.60, 1.00]; visual AUC = .84, 95% CI [.66, 1.00], and audiovisual AUC = .83, 95% CI [.63, 1.00]). Results suggest that computer-generated characters allow accurate discrimination of sex offenders with child victims and can be added to already validated stimuli to increase the number of valid profiles. The implications of audiovisual stimuli using computer-generated characters and their possible use in PPG evaluations are also discussed.

Learning from Youth Marketers: Adapting to the Schoolhouse What Business Already Knows about the Millennials

ERIC Educational Resources Information Center

Geraci, John C.

2005-01-01

Today's education leaders live in interesting times. As the parent-centric households of the Generation X era have given way to the child-centered households of the Millennial generation, increased pressure has been placed on educators from parents, communities and government. Boomer-aged educational leaders, who honed their careers as Gen-X was…

Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis.

PubMed

Lin, Mai; Ranganathan, David; Mori, Tetsuya; Hagooly, Aviv; Rossin, Raffaella; Welch, Michael J; Lapi, Suzanne E

2012-10-01

Interest in using (68)Ga is rapidly increasing for clinical PET applications due to its favorable imaging characteristics and increased accessibility. The focus of this study was to provide our long-term evaluations of the two TiO(2)-based (68)Ge/(68)Ga generators and develop an optimized automation strategy to synthesize [(68)Ga]DOTATOC by using HEPES as a buffer system. This data will be useful in standardizing the evaluation of (68)Ge/(68)Ga generators and automation strategies to comply with regulatory issues for clinical use. Copyright © 2012 Elsevier Ltd. All rights reserved.

Bundling of ecosystem services to increase forestland value and enhance sustainable forest management

Treesearch

Robert L. Deal; Bobby Cochran; Gina LaRocco

2012-01-01

There has been increasing interest in the use of market-based approaches to add value for forestland and to assist with the conservation of natural resources. While markets for ecosystem services show potential for increasing forestland value, there is concern that the lack of an integrated program will simply add to the complexity of these services without generating...

Real-Time Seismic Displays in Museums Appeal to the Public

NASA Astrophysics Data System (ADS)

Smith, Meagan; Taber, John; Hubenthal, Michael

2006-02-01

Technology provides people with constant access to the latest news, weather, and entertainment. Not surprisingly, the public increasingly demands that the most current information be available for immediate consumption. For museums striving to educate the public and to maintain and expand visitor interest, gone are the days of passively conveying scientific concepts through static displays. Instead, science museums must find creative ways to capture the public's interest-successful advocacy for research funding, solutions to environmental problems, even future generations' scientific innovation depend on this. To this end, the continuous collection and dissemination of real-time science information by the scientific community offers museums an opportunity to capitalize on visitors' data addiction and increase the public's interest in, and understanding of, the Earth system.

WASTEWATER RENOVATION AND RETRIEVAL ON CAPE COD

EPA Science Inventory

A rapidly increasing population on maritime Cape Cod has generated considerable interest in alternative wastewater disposal techniques which promise to maintain high groundwater quality and promote its conservation. The authors undertake an assessment of agricultural spray-irriga...

Evaluating the iPad Mini® as a Speech-Generating Device in the Acquisition of a Discriminative Mand Repertoire for Young Children with Autism

ERIC Educational Resources Information Center

Lorah, Elizabeth R.

2018-01-01

There has been an increased interest in research evaluating the use of handheld computing technology as speech-generating devices (SGD) for children with autism. However, given the reliance on single-subject research methodology, replications of these investigations are necessary. This study presents a replication with variation, of a method for…

Effect of nitrogen addition to ozone generation characteristics by diffuse and filamentary dielectric barrier discharges at atmospheric pressure

NASA Astrophysics Data System (ADS)

Osawa, Naoki; Tsuji, Takafumi; Ogiso, Ryota; Yoshioka, Yoshio

2017-05-01

Ozone is widely used for gas treatment, advanced oxidation processes, microorganisms inactivation, etc. In this research, we investigated the effect of nitrogen addition to ozone generation characteristics by atmospheric pressure Townsend discharge (APTD) type and filamentary dielectric barrier discharge (DBD) type ozone generators. The result showed that the ozone generated by the filamentary DBD increases rapidly with the increase of O2 content, and is higher than that by the APTD. On the other hand, it is interesting that the ozone generated by the APTD gradually decreases with the increase of O2 content. In order to clarify why the characteristics of ozone generation by the two kinds of discharge modes showed different dependency to the N2 content, we analyzed the exhaust gas composition using FTIR spectroscopy and calculated the rate coefficients using BOLSIG+ code. As a result, we found that although O2 content decreased with increasing N2 content, additional O atoms produced by excited N2 molecules contribute to ozone generation in case of APTD. Contribution to the topical issue "The 15th International Symposium on High Pressure Low Temperature Plasma Chemistry (HAKONE XV)", edited by Nicolas Gherardi and Tomáš Hoder

Present Status and Future Developments in Proton Therapy

NASA Astrophysics Data System (ADS)

Smith, Alfred R.

2009-07-01

Within the past few years, interest in proton therapy has significantly increased. This interest has been generated by a number of factors including: 1) the reporting of positive clinical results using proton beams; 2) approval of reimbursement for delivery of proton therapy; 3) the success of hospital-based proton therapy centers; and 4) the availability of modern, integrated proton therapy technology for hospital-based facilities. In the United States, this increased interest has occurred particularly at the level of smaller academic hospitals, community medical centers, and large private practices; however, interest from large academic centers continues to be strong. Particular interest exists regarding smaller and less-expensive proton therapy systems, especially the so-called "single-room" systems. In this paper, the advantages and disadvantages of 1-room proton therapy systems will be discussed. The emphasis on smaller and cheaper proton therapy facilities has also generated interest in new proton-accelerating technologies such as superconducting cyclotrons and synchrocyclotrons, laser acceleration, and dielectric-wall accelerators. Superconducting magnets are also being developed to decrease the size and weight of isocentric gantries. Another important technical development is spot-beam scanning, which offers the ability to deliver intensity-modulated proton treatments (IMPT). IMPT has the potential to provide dose distributions that are superior to those for photon intensity modulation techniques (IMXT) and to improve clinical outcomes for patients undergoing cancer therapy. At the present time, only two facilities—one in Europe and one in the United States—have the ability to deliver IMPT treatments, however, within the next year or two several additional facilities are expected to achieve this capability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doris, E.; Krasko, V.A.

State and local policymakers show increasing interest in spurring the development of customer-sited distributed generation (DG), in particular solar photovoltaic (PV) markets. Prompted by that interest, this analysis examines the use of state policy as a tool to support the development of a robust private investment market. This analysis builds on previous studies that focus on government subsidies to reduce installation costs of individual projects and provides an evaluation of the impacts of policies on stimulating private market development.

"The Future Is Ours Too": A Training Process to Enable the Learning Perception and Increase Self-Efficacy in the Use of Tablets in the Elderly

ERIC Educational Resources Information Center

Gatti, Fabiana M.; Brivio, Eleonora; Galimberti, Carlo

2017-01-01

The generational digital divide can be understood as a response to the physical and psychosocial decline of older people. Recently, there has been interest in reducing the generational digital divide because of societal costs, and several studies state that tablets seem to help the elderly due to usability and functions that easily fulfill the…

Communicating River Level Data and Information to Stakeholders with Different Interests

NASA Astrophysics Data System (ADS)

Macleod, K.; Sripada, S.; Ioris, A.; Arts, K.; van der Wal, R.

2012-12-01

There is a need to increase the effectiveness of how river level data are communicated to a range of stakeholders with an interest in river level information to increase the use of data collected by regulatory agencies. Currently, river level data is provided to members of the public through a web site without any formal engagement with river users having taken place. In our research project called wikiRivers, we are working with the suppliers of river level data as well as the users of this data to explore and improve from the user perspective how river level data and information is made available online. We are focusing on the application of natural language generation technology to create textual summaries of river level data tailored for specific interest groups. These tailored textual summaries will be presented among other modes of information presentation (e.g. maps and visualizations) with the aim to increase communication effectiveness. Natural language generation involves developing computational models that use non-linguistic input data to produce natural language as their output. Acquiring accurate correct system knowledge for natural language generation is a key step in developing such an effective computer software system. In this paper we set out the needs for this project based on discussions with the stakeholder who supplies the river level data and current cyberinfrastructure and report on what we have learned from those individuals and groups who use river level data. Stages in the wikiRivers stakeholder identification, engagement and cyberinfrastructure development. S1- interviews with collectors and suppliers of river level data. S2- river level data stakeholder analysis, including analysis of their interests in individual river networks in Scotland and what they require from the cyberinfrastructure. S3-5 Iterative development and testing of cyberinfrastructure and modelling of river level data with domain and stakeholder knowledge.

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.

PubMed

Morales, Paula; Reggio, Patricia H; Jagerovic, Nadine

2017-01-01

Cannabidiol (CBD) has been traditionally used in Cannabis -based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis . Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic, antipsychotic, and anti-inflammatory properties. Therefore, the CBD scaffold becomes of increasing interest for medicinal chemists. This review provides an overview of the chemical structure of natural and synthetic CBD derivatives including the molecular targets associated with these compounds. A clear identification of their biological targets has been shown to be still very challenging.

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol

PubMed Central

Morales, Paula; Reggio, Patricia H.; Jagerovic, Nadine

2017-01-01

Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic, antipsychotic, and anti-inflammatory properties. Therefore, the CBD scaffold becomes of increasing interest for medicinal chemists. This review provides an overview of the chemical structure of natural and synthetic CBD derivatives including the molecular targets associated with these compounds. A clear identification of their biological targets has been shown to be still very challenging. PMID:28701957

Heat Pipe Materials Compatibility

NASA Technical Reports Server (NTRS)

Eninger, J. E.; Fleischman, G. L.; Luedke, E. E.

1976-01-01

An experimental program to evaluate noncondensable gas generation in ammonia heat pipes was completed. A total of 37 heat pipes made of aluminum, stainless steel and combinations of these materials were processed by various techniques, operated at different temperatures and tested at low temperature to quantitatively determine gas generation rates. In order of increasing stability are aluminum/stainless combination, all aluminum and all stainless heat pipes. One interesting result is the identification of intentionally introduced water in the ammonia during a reflux step as a means of surface passivation to reduce gas generation in stainless-steel/aluminum heat pipes.

Residents values in a rational decision-making model: an interest in academics in emergency medicine.

PubMed

Burkhardt, John Christian; Smith-Coggins, Rebecca; Santen, Sally

2016-10-01

Academic physicians train the next generation of doctors. It is important to understand the factors that lead residents to choose an academic career to continue to effectively recruit residents who will join the national medical faculty. A decision-making theory-driven, large scale assessment of this process has not been previously undertaken. To examine the factors that predict an Emergency resident's interest in pursuing an academic career at the conclusion of training. This study employs the ABEM Longitudinal Survey (n = 365). A logistic regression model was estimated using an interest in an academic career in residency as the dependent variable. Independent variables include gender, under-represented minority status, survey cohort, number of dependent children, possession of an advanced degree, ongoing research, publications, and the appeal of science, independence, and clinical work in choosing EM. Logistic regression resulted in a statistically significant model (p < 0.001). Residents who chose EM due to the appeal of science, had peer-reviewed publications and ongoing research were more likely to be interested in an academic career at the end of residency (p < 0.05). An increased number of children (p < 0.05) was negatively associated with an interest in academics. Individual resident career interests, research productivity, and lifestyle can help predict an interest in pursuing an academic career. Recruitment and enrichment of residents who have similar values and behaviors should be considered in programs interested in generating more graduates who enter an academic career.

Increasing High School Students' Interest in STEM Education through Collaborative Brainstorming with Yo-Yos

ERIC Educational Resources Information Center

Fang, Ning

2013-01-01

Brainstorming is a creativity technique in which a group of people (or an individual person) spontaneously generates a set of ideas to find the solution to a particular problem. This paper describes an innovative approach called "brainstorming with yo-yos," which was implemented in an outreach to high school event to increase high school…

The importance of including dynamic social networks when modeling epidemics of airborne infections: does increasing complexity increase accuracy?

PubMed

Blower, Sally; Go, Myong-Hyun

2011-07-19

Mathematical models are useful tools for understanding and predicting epidemics. A recent innovative modeling study by Stehle and colleagues addressed the issue of how complex models need to be to ensure accuracy. The authors collected data on face-to-face contacts during a two-day conference. They then constructed a series of dynamic social contact networks, each of which was used to model an epidemic generated by a fast-spreading airborne pathogen. Intriguingly, Stehle and colleagues found that increasing model complexity did not always increase accuracy. Specifically, the most detailed contact network and a simplified version of this network generated very similar results. These results are extremely interesting and require further exploration to determine their generalizability.

Sound Generation in the Presence of Moving Surfaces with Application to Internally Generated Aircraft Engine Noise

NASA Technical Reports Server (NTRS)

Goldstein, Marvin E.; Envia, E.

2002-01-01

In many cases of technological interest solid boundaries play a direct role in the aerodynamic sound generation process and their presence often results in a large increase in the acoustic radiation. A generalized treatment of the emission of sound from moving boundaries is presented. The approach is similar to that of Ffowcs Williams and Hawkings (1969) but the effect of the surrounding mean flow is explicitly accounted for. The results are used to develop a rational framework for the prediction of internally generated aero-engine noise. The final formulas suggest some new noise sources that may be of practical significance.

Development of a Novel Quantitative Adverse Outcome Pathway Predictive Model for Lung Cancer

EPA Science Inventory

Traditional methods for carcinogenicity testing are resource-intensive, retrospective, and time consuming. An increasing testing burden has generated interest in the adverse outcome pathway (AOP) concept as a tool to evaluate chemical safety in a more efficient, rapid and effecti...

NITROUS OXIDE BEHAVIOR IN THE ATMOSPHERE, AND IN COMBUSTION AND INDUSTRIAL SYSTEMS

EPA Science Inventory

Tropospheric measurements show that nitrous oxide (N2O) concentrations are increasing over time. This demonstrates the existence of one or more significant anthropogenic sources, a fact that has generated considerable research interest over the last several years. The debate has ...

Investigating Turkish Primary School Students' Interest in Science by Using Their Self-Generated Questions

ERIC Educational Resources Information Center

Cakmakci, Gultekin; Sevindik, Hatice; Pektas, Meryem; Uysal, Asli; Kole, Fatma; Kavak, Gamze

2012-01-01

This paper reports on an attempt to investigate Turkish primary school students' interest in science by using their self-generated questions. We investigated students' interest in science by analyzing 1704 self-generated science-related questions. Among them, 826 questions were submitted to a popular science magazine called Science and Children.…

The era of the wandering mind? Twenty-first century research on self-generated mental activity.

PubMed

Callard, Felicity; Smallwood, Jonathan; Golchert, Johannes; Margulies, Daniel S

2013-01-01

The first decade of the twenty-first century was characterized by renewed scientific interest in self-generated mental activity (activity largely generated by the individual, rather than in direct response to experimenters' instructions or specific external sensory inputs). To understand this renewal of interest, we interrogated the peer-reviewed literature from 2003 to 2012 (i) to explore recent changes in use of terms for self-generated mental activity; (ii) to investigate changes in the topics on which mind wandering research, specifically, focuses; and (iii) to visualize co-citation communities amongst researchers working on self-generated mental activity. Our analyses demonstrated that there has been a dramatic increase in the term "mind wandering" from 2006, and a significant crossing-over of psychological investigations of mind wandering into cognitive neuroscience (particularly in relation to research on the default mode and default mode network). If our article concludes that this might, indeed, be the "era of the wandering mind," it also calls for more explicit reflection to be given by researchers in this field to the terms they use, the topics and brain regions they focus on, and the research literatures that they implicitly foreground or ignore.

The era of the wandering mind? Twenty-first century research on self-generated mental activity

PubMed Central

Callard, Felicity; Smallwood, Jonathan; Golchert, Johannes; Margulies, Daniel S.

2013-01-01

The first decade of the twenty-first century was characterized by renewed scientific interest in self-generated mental activity (activity largely generated by the individual, rather than in direct response to experimenters’ instructions or specific external sensory inputs). To understand this renewal of interest, we interrogated the peer-reviewed literature from 2003 to 2012 (i) to explore recent changes in use of terms for self-generated mental activity; (ii) to investigate changes in the topics on which mind wandering research, specifically, focuses; and (iii) to visualize co-citation communities amongst researchers working on self-generated mental activity. Our analyses demonstrated that there has been a dramatic increase in the term “mind wandering” from 2006, and a significant crossing-over of psychological investigations of mind wandering into cognitive neuroscience (particularly in relation to research on the default mode and default mode network). If our article concludes that this might, indeed, be the “era of the wandering mind,” it also calls for more explicit reflection to be given by researchers in this field to the terms they use, the topics and brain regions they focus on, and the research literatures that they implicitly foreground or ignore. PMID:24391606

4. Carbon Changes in U.S. Forests

Treesearch

R.A. Birdsey; L.S. Heath

1995-01-01

Global concern about increasing atmospheric concentrations of greenhouse gases, particularly carbon dioxide (CO2), and the possible consequences of future climate changes, has generated interest in understanding and quantifying the role of terrestrial ecosystems in the global carbon cycle. Recent efforts to quantify the global carbon budget have...

Technical assistance for hazardous-waste reduction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thompson, F.M.; McComas, C.A.

1987-12-01

Minnesota's Waste Management Board has established, developed, and funded the Minnesota Technical Assistance Program (MnTAP). The MnTAP programs offers technical assistance to generators of hazardous waste by offering telephone and onsite consultation, a waste reduction resource bank, information dissemination, a student intern program, and research awards for waste reduction projects. The program has completed three years of successful operation. The increasing interest in and use of MnTAP's services by hazardous-waste generators has justified the belief that state technical assistance programs have an important role to play in helping generators to reduce their waste production.

Of paradise and clean power: The effect of California's renewable portfolio standard on in-state renewable energy generation

NASA Astrophysics Data System (ADS)

Yin, Clifton Lee

Renewable portfolio standards (RPS), policies that encourage acquisition of electricity from renewable energy sources, have become popular instruments for discouraging the use of climate change inducing-fossil fuels. There has been limited research, however, that empirically evaluates their effectiveness. Using data gathered by three governmental entities -- the federal-level Energy Information Administration and two California agencies, the Employment Development Department and the Department of Finance -- this paper investigates the impact of California's RPS, one of the nation's most ambitious such policies, on in-state renewable energy generation. It finds that the California RPS did not bring about a one-time increase in generation with its inception, nor did it compel an increase in generation over time. These results raise questions as to the best way to structure RPS policies in light of growing interest in the establishment of a national RPS.

Air Toxics Under the Big Sky: Examining the Effectiveness of Authentic Scientific Research on High School Students' Science Skills and Interest.

PubMed

Ward, Tony J; Delaloye, Naomi; Adams, Earle Raymond; Ware, Desirae; Vanek, Diana; Knuth, Randy; Hester, Carolyn Laurie; Marra, Nancy Noel; Holian, Andrij

2016-01-01

Air Toxics Under the Big Sky is an environmental science outreach/education program that incorporates the Next Generation Science Standards (NGSS) 8 Practices with the goal of promoting knowledge and understanding of authentic scientific research in high school classrooms through air quality research. A quasi-experimental design was used in order to understand: 1) how the program affects student understanding of scientific inquiry and research and 2) how the open inquiry learning opportunities provided by the program increase student interest in science as a career path . Treatment students received instruction related to air pollution (airborne particulate matter), associated health concerns, and training on how to operate air quality testing equipment. They then participated in a yearlong scientific research project in which they developed and tested hypotheses through research of their own design regarding the sources and concentrations of air pollution in their homes and communities. Results from an external evaluation revealed that treatment students developed a deeper understanding of scientific research than did comparison students, as measured by their ability to generate good hypotheses and research designs, and equally expressed an increased interest in pursuing a career in science. These results emphasize the value of and need for authentic science learning opportunities in the modern science classroom.

Air Toxics Under the Big Sky: examining the effectiveness of authentic scientific research on high school students' science skills and interest

NASA Astrophysics Data System (ADS)

Ward, Tony J.; Delaloye, Naomi; Adams, Earle Raymond; Ware, Desirae; Vanek, Diana; Knuth, Randy; Hester, Carolyn Laurie; Marra, Nancy Noel; Holian, Andrij

2016-04-01

Air Toxics Under the Big Sky is an environmental science outreach/education program that incorporates the Next Generation Science Standards (NGSS) 8 Practices with the goal of promoting knowledge and understanding of authentic scientific research in high school classrooms through air quality research. This research explored: (1) how the program affects student understanding of scientific inquiry and research and (2) how the open-inquiry learning opportunities provided by the program increase student interest in science as a career path. Treatment students received instruction related to air pollution (airborne particulate matter), associated health concerns, and training on how to operate air quality testing equipment. They then participated in a yearlong scientific research project in which they developed and tested hypotheses through research of their own design regarding the sources and concentrations of air pollution in their homes and communities. Results from an external evaluation revealed that treatment students developed a deeper understanding of scientific research than did comparison students, as measured by their ability to generate good hypotheses and research designs, and equally expressed an increased interest in pursuing a career in science. These results emphasize the value of and need for authentic science learning opportunities in the modern science classroom.

Air Toxics Under the Big Sky: Examining the Effectiveness of Authentic Scientific Research on High School Students’ Science Skills and Interest

PubMed Central

Delaloye, Naomi; Adams, Earle Raymond; Ware, Desirae; Vanek, Diana; Knuth, Randy; Hester, Carolyn Laurie; Marra, Nancy Noel; Holian, Andrij

2016-01-01

Air Toxics Under the Big Sky is an environmental science outreach/education program that incorporates the Next Generation Science Standards (NGSS) 8 Practices with the goal of promoting knowledge and understanding of authentic scientific research in high school classrooms through air quality research. A quasi-experimental design was used in order to understand: 1) how the program affects student understanding of scientific inquiry and research and 2) how the open inquiry learning opportunities provided by the program increase student interest in science as a career path. Treatment students received instruction related to air pollution (airborne particulate matter), associated health concerns, and training on how to operate air quality testing equipment. They then participated in a yearlong scientific research project in which they developed and tested hypotheses through research of their own design regarding the sources and concentrations of air pollution in their homes and communities. Results from an external evaluation revealed that treatment students developed a deeper understanding of scientific research than did comparison students, as measured by their ability to generate good hypotheses and research designs, and equally expressed an increased interest in pursuing a career in science. These results emphasize the value of and need for authentic science learning opportunities in the modern science classroom. PMID:28286375

Maximum capacity model of grid-connected multi-wind farms considering static security constraints in electrical grids

NASA Astrophysics Data System (ADS)

Zhou, W.; Qiu, G. Y.; Oodo, S. O.; He, H.

2013-03-01

An increasing interest in wind energy and the advance of related technologies have increased the connection of wind power generation into electrical grids. This paper proposes an optimization model for determining the maximum capacity of wind farms in a power system. In this model, generator power output limits, voltage limits and thermal limits of branches in the grid system were considered in order to limit the steady-state security influence of wind generators on the power system. The optimization model was solved by a nonlinear primal-dual interior-point method. An IEEE-30 bus system with two wind farms was tested through simulation studies, plus an analysis conducted to verify the effectiveness of the proposed model. The results indicated that the model is efficient and reasonable.

Implications of the method of capital cost payment on the weighted average cost of capital.

PubMed Central

Boles, K E

1986-01-01

The author develops a theoretical and mathematical model, based on published financial management literature, to describe the cost of capital structure for health care delivery entities. This model is then used to generate the implications of changing the capital cost reimbursement mechanism from a cost basis to a prospective basis. The implications are that the cost of capital is increased substantially, the use of debt must be restricted, interest rates for borrowed funds will increase, and, initially, firms utilizing debt efficiently under cost-basis reimbursement will be restricted to the generation of funds from equity only under a prospective system. PMID:3525468

International Perspectives on Early Childhood Curricula

ERIC Educational Resources Information Center

Oberhuemer, Pamela

2005-01-01

The early years of childhood are receiving increased public policy attention in many countries around the world. Debates on providing quality services and ensuring a good foundation for lifelong learning are generating a new interest in curriculum issues. What understandings do we have of young children? How do they access and construct knowledge…

Information Needs for Student and Public Choice in Postsecondary Education.

ERIC Educational Resources Information Center

Shapiro, Paul S.

There has been an increasing movement toward consumer protection in recent years, sparked by a few crusaders, a better educated public, and changing socioeconomic conditions. What is new is the interest being generated under the rubric of consumer protection in postsecondary education. This conception of consumer protection deals almost…

Electrostatic and conventional spraying of alginate-based edible coating with natural antimicrobials for preserving fresh strawberry quality

USDA-ARS?s Scientific Manuscript database

Microbial contamination and mold growth are common causes of strawberries deterioration during storage. The growing need for extending shelf-life while enhancing the overall quality of perishable fruits has generated increasing interest in the development of novel storage technologies. This study us...

Syllabus and Economics: Reasoning with Generation "Why"

ERIC Educational Resources Information Center

Burdina, Mariya; Sasser, Sue Lynn

2018-01-01

In this article, the authors propose to enhance the syllabus for economic courses with economic explanations. They argue that providing economic rationale for course policies can increase student interest in the course and at the same time positively affect student attitude toward course policies. The authors describe practical strategies for…

Optimized separation procedures for the simultaneous assay of three plant hormones in liquid biofertilizers

USDA-ARS?s Scientific Manuscript database

The overuse of petrochemical-based synthetic fertilizers has caused detrimental effects to soil, water supplies, foods, and animal health. This, in addition to increased awareness of organic farming, has generated considerable interest in the evaluation of renewable biofertilizers. In order to stu...

A Preliminary Examination of Covitality as Integrated Well-Being in College Students

ERIC Educational Resources Information Center

Jones, Camille N.; You, Sukkyung; Furlong, Michael J.

2013-01-01

The emergence of positive psychology has generated increased interest about the correlates of positive psychological functioning. Researchers have identified and studied various positive psychological constructs (e.g., hope, optimism, self-efficacy, gratitude, and life satisfaction) and found them to covary and to be positively associated with…

NEXT GENERATION LEACHING TESTS FOR EVALUATING LEACHING OF INORGANIC CONSTITUENTS

EPA Science Inventory

In the U.S. as in other countries, there is increased interest in using industrial by-products as alternative or secondary materials, helping to conserve virgin or raw materials. The LEAF and associated test methods are being used to develop the source term for leaching or any i...

Cornstarch complexed with a soybean oil component imparts water resistance to paper

USDA-ARS?s Scientific Manuscript database

The increasing trend of using paper instead of plastic for many products for environmental and sustainability reasons has generated much interest new technologies for making paper water resistant. Most of the widely used methods and recent reports involve the use of non-biobased, synthetic materials...

Shared Interests: Public Funding Challenges Increase Appeal of For-Profit Partners

ERIC Educational Resources Information Center

Jackson, Nancy Mann

2013-01-01

The current financial crisis in higher education is driving more public institutions to look at alternative ways to generate support. Many are leveraging longstanding relationships with private corporations, seeking ways to expand their involvement. Supporters who once simply made philanthropic contributions are becoming strategically involved…

Increasing Interest of Mass Communication Media and the General Public in the Distribution of Tweets About Mental Disorders: Observational Study

PubMed Central

Asunsolo del Barco, Angel; Lahera, Guillermo; Quintero, Javier; Ferre, Francisco; Pereira-Sanchez, Victor; Ortuño, Felipe; Alvarez-Mon, Melchor

2018-01-01

Background The contents of traditional communication media and new internet social media reflect the interests of society. However, certain barriers and a lack of attention towards mental disorders have been previously observed. Objective The objective of this study is to measure the relevance of influential American mainstream media outlets for the distribution of psychiatric information and the interest generated in these topics among their Twitter followers. Methods We investigated tweets generated about mental health conditions and diseases among 15 mainstream general communication media outlets in the United States of America between January 2007 and December 2016. Our study strategy focused on identifying several psychiatric terms of primary interest. The number of retweets generated from the selected tweets was also investigated. As a control, we examined tweets generated about the main causes of death in the United States of America, the main chronic neurological degenerative diseases, and HIV. Results In total, 13,119 tweets about mental health disorders sent by the American mainstream media outlets were analyzed. The results showed a heterogeneous distribution but preferential accumulation for a select number of conditions. Suicide and gender dysphoria accounted for half of the number of tweets sent. Variability in the number of tweets related to each control disease was also found (5998). The number of tweets sent regarding each different psychiatric or organic disease analyzed was significantly correlated with the number of retweets generated by followers (1,030,974 and 424,813 responses to mental health disorders and organic diseases, respectively). However, the probability of a tweet being retweeted differed significantly among the conditions and diseases analyzed. Furthermore, the retweeted to tweet ratio was significantly higher for psychiatric diseases than for the control diseases (odds ratio 1.11, CI 1.07-1.14; P<.001). Conclusions American mainstream media outlets and the general public demonstrate a preferential interest for psychiatric diseases on Twitter. The heterogeneous weights given by the media outlets analyzed to the different mental health disorders and conditions are reflected in the responses of Twitter followers. PMID:29807880

Water laws and concepts

USGS Publications Warehouse

Thomas, H.E.

1970-01-01

Throughout human history various laws and customs have developed concerning the individual rights and rights in common to the waters of the earth. Many existing laws and concepts are clearly influenced by the environment in which they originated and reflect the relative abundance or scarcity of water. Many concepts reflect the people's original interests in the water and once established have been passed from generation to generation with little modification. Some laws and concepts have been carried by people in their migrations and colonial expansions to vastly different environments, with rather curious consequences. In many places water laws that had been well adapted to the natural environment have become less tenable because of man's activities in modifying that environment, or because of increasing use of water: Increasing consumptive use shifts the water economy toward lesser abundance or increasing deficiency; increasing nonconsumptive use results in pollution of the water resources, so that they become less suitable for other users. The water-rights systems in the United States vary from State to State: some are reasonably fitted to their environment, some have outlived their place in history, some are wasteful of water, some show favoritism to certain special interests or segments of the population. Water-use rights are universally recognized as real property, with constitutional protection against deprivation without due process of law.

Setting the stage - building and working in an ancient DNA laboratory.

PubMed

Knapp, Michael; Clarke, Andrew C; Horsburgh, K Ann; Matisoo-Smith, Elizabeth A

2012-01-20

With the introduction of next generation high throughput sequencing in 2005 and the resulting revolution in genetics, ancient DNA research has rapidly developed from an interesting but marginal field within evolutionary biology into one that can contribute significantly to our understanding of evolution in general and the development of our own species in particular. While the amount of sequence data available from ancient human, other animal and plant remains has increased dramatically over the past five years, some key limitations of ancient DNA research remain. Most notably, reduction of contamination and the authentication of results are of utmost importance. A number of studies have addressed different aspects of sampling, DNA extraction and DNA manipulation in order to establish protocols that most efficiently generate reproducible and authentic results. As increasing numbers of researchers from different backgrounds become interested in using ancient DNA technology to address key questions, the need for practical guidelines on how to construct and use an ancient DNA facility arises. The aim of this article is therefore to provide practical tips for building a state-of-the-art ancient DNA facility. It is intended to help researchers new to the field of ancient DNA research generally, and those considering the application of next generation sequencing, in their planning process. Copyright © 2011 Elsevier GmbH. All rights reserved.

Two-fold Bioorthogonal Derivatization by Different Formylglycine-Generating Enzymes.

PubMed

Krüger, Tobias; Weiland, Stefanie; Falck, Georg; Gerlach, Marcus; Boschanski, Mareile; Alam, Sarfaraz; Müller, Kristian M; Dierks, Thomas; Sewald, Norbert

2018-03-26

Formylglycine-generating enzymes are of increasing interest in the field of bioconjugation chemistry. They catalyze the site-specific oxidation of a cysteine residue to the aldehyde-containing amino acid C α -formylglycine (FGly). This non-canonical residue can be generated within any desired target protein and can subsequently be used for bioorthogonal conjugation reactions. The prototypic formylglycine-generating enzyme (FGE) and the iron-sulfur protein AtsB display slight variations in their recognition sequences. We designed specific tags in peptides and proteins that were selectively converted by the different enzymes. Combination of the different tag motifs within a single peptide or recombinant protein enabled the independent and consecutive introduction of two formylglycine residues and the generation of heterobifunctionalized protein conjugates. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Increasing chronic disease research capacity in Guatemala through a mentoring program.

PubMed

Barnoya, Joaquin; Monzon, Jose C; Colditz, Graham A

2013-09-12

The Chronic Disease Research Fellowship Program (RFP) aims to build the research capacity of recent medical graduates to support the development of chronic disease control strategies. Guatemala is undergoing an epidemiologic transition. However, given the way universities and the health care system are structured, it lacks an environment that fosters research careers and generates the required knowledge to implement sound public health policies and clinical strategies. The RFP was implemented at the Cardiovascular Unit of Guatemala. This 4-year Program recruited two one-year fellows and provided funding to define a research topic, write a protocol and implement the research. Strong emphasis is placed on developing skills in knowledge translation and exchange to bridge the "know-do" gap. Close mentoring relationships between the Principal Investigator and former and current fellows are fostered through the Program. The mentoring Program has generated strategic data to support the implementation of sound chronic disease control strategies, mainly related to tobacco control. Results have been presented nationally and internationally. Research training has included principles of biostatistics and epidemiology, and a journal club. The Program is increasingly generating interest among medical graduates to pursue further research training abroad and is building local research capacity. Fellows and research assistants have created a research network in Guatemala and abroad. The main obstacle the Program faces is ensuring long-term sustainability. A mentoring program can lead to an increase in research interest and capacity in a low-income country with little research infrastructure.

Enhancing Student Learning in Food Engineering Using Computational Fluid Dynamics Simulations

ERIC Educational Resources Information Center

Wong, Shin Y.; Connelly, Robin K.; Hartel, Richard W.

2010-01-01

The current generation of students coming into food science and engineering programs is very visually oriented from their early experiences. To increase their interest in learning, new and visually appealing teaching materials need to be developed. Two diverse groups of students may be identified based on their math skills. Food science students…

Assessing the potential for conversion to biomass fuels in interior Alaska.

Treesearch

Nancy Fresco; F. Stuart Chapin

2009-01-01

In rural Alaskan communities, high economic, social, and ecological costs are associated with fossil fuel use for power generation. Local concerns regarding fuel prices, environmental contamination, and the effects of global climate change have resulted in increased interest in renewable energy sources. In this study, we assessed the feasibility of switching from...

Pacific Yew: A Facultative Riparian Conifer with an Uncertain Future

Treesearch

Stanley Scher; Bert Schwarzschild

1989-01-01

Increasing demands for Pacific yew bark, a source of an anticancer agent, have generated interest in defining the yew resource and in exploring strategies to conserve this species. The distribution, riparian requirements and ecosystem functions of yew populations in coastal and inland forests of northern California are outlined and alternative approaches to conserving...

Increasing Physical Activity during the School Day through Physical Activity Classes: Implications for Physical Educators

ERIC Educational Resources Information Center

Adkins, Megan; Bice, Matt; Bartee, Todd; Heelan, Kate

2015-01-01

Across the nation schools are adopting health and wellness policies, specifically physical activity (PA) initiatives that aid healthy long-term lifestyles. Interest has been generated about the inclusion of physical activity classes to complement existing physical education classes. Furthermore, discussion has evolved as to if additional…

Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom

ERIC Educational Resources Information Center

Yang, Xinmiao; Hartman, Mark R.; Harrington, Kristin T.; Etson, Candice M.; Fierman, Matthew B.; Slonim, Donna K.; Walt, David R.

2017-01-01

With the development of new sequencing and bioinformatics technologies, concepts relating to personal genomics play an increasingly important role in our society. To promote interest and understanding of sequencing and bioinformatics in the high school classroom, we developed and implemented a laboratory-based teaching module called "The…

Animated Pedagogical Agents: A Review of Agent Technology Software in Electronic Learning Environments

ERIC Educational Resources Information Center

Govindasamy, Malliga K.

2014-01-01

Agent technology has become one of the dynamic and most interesting areas of computer science in recent years. The dynamism of this technology has resulted in computer generated characters, known as pedagogical agent, entering the digital learning environments in increasing numbers. Commonly deployed in implementing tutoring strategies, these…

School Choice Policies and Outcomes: Empirical and Philosophical Perspectives

ERIC Educational Resources Information Center

Feinberg, Walter, Ed.; Lubienski, Christopher, Ed.

2008-01-01

Perhaps no school reform has generated as much interest and controversy in recent years as the proposal to have parents select their children's schools. Opponents of school choice fear that rolling back the government's role will lead to profit-driven financial scandals, sectarianism, and increased class and racial isolation. School choice…

Congressional Television: Attempts to Implement Televised Coverage of the U.S. Congress.

ERIC Educational Resources Information Center

Garay, Ronald

In 1970, the Legislative Reorganization Act authorized the U.S. Senate and House of Representatives to open their committee meetings to both radio and television. Three factors increased interest in implementing media coverage of such meetings: feasibility of televised coverage, public cynicism and hostility generated by misinformation and…

An Ecological Context for Regenerating Mult-cohort, Mixed-species Red Pine Forests

Treesearch

Brian Palik; John Zasada

2003-01-01

Human disturbances have simplified the structure and composition of red pine forest, relative to historical conditions. A greater understanding of natureal disturbances and their role in generating complex stand structures, and their associated benefits, has increased interest in managing for mixed-species, multi-aged stands. We outline a conceptual approach for...

A Trillion-Dollar Question: What Predicts Student Loan Delinquencies?

ERIC Educational Resources Information Center

Mezza, Alvaro; Sommer, Kamila

2016-01-01

The recent significant increase in student loan delinquencies has generated interest in understanding the key factors predicting the non-performance of these loans. However, despite the large size of the student loan market, existing analyses have been limited by lack of data. This paper studies predictors of student loan delinquencies using a…

Biomass as a Sustainable Energy Source: An Illustration of Chemical Engineering Thermodynamic Concepts

ERIC Educational Resources Information Center

Mohan, Marguerite A.; May, Nicole; Assaf-Anid, Nada M.; Castaldi, Marco J.

2006-01-01

The ever-increasing global demand for energy has sparked renewed interest within the engineering community in the study of sustainable alternative energy sources. This paper discusses a power generation system which uses biomass as "fuel" to illustrate the concepts taught to students taking a graduate level chemical engineering process…

Current Concepts in Sports-related Concussion.

PubMed

Feden, Jeffrey P

2016-10-04

Increasing concern over the acute and long-term consequences of sports-related concussion has generated widespread interest and attention. This article provides an overview of concussion in athletes, including diagnostic and management considerations, and highlights the clinical challenges associated with repeated minor head trauma in sports. [Full article available at http://rimed.org/rimedicaljournal-2016-10.asp].

Economic and Cultural Factors Affecting University Excellence

ERIC Educational Resources Information Center

Jabnoun, Naceur

2009-01-01

Purpose: The ranking of top universities in the world has generated increased interest in the factors that enhance university performance. The purpose of this paper is to identify economic and cultural factors that affect the number of top ranking universities in each country. Design/methodology/approach: This paper first identifies the number of…

Direct femtosecond laser ablation of copper with an optical vortex beam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anoop, K. K.; Rubano, A.; Marrucci, L.

Laser surface structuring of copper is induced by laser ablation with a femtosecond optical vortex beam generated via spin-to-orbital conversion of the angular momentum of light by using a q-plate. The variation of the produced surface structures is studied as a function of the number of pulses, N, and laser fluence, F. After the first laser pulse (N=1), the irradiated surface presents an annular region characterized by a corrugated morphology made by a rather complex network of nanometer-scale ridges, wrinkles, pores, and cavities. Increasing the number of pulses (21000) and a deep crater is formed. The nanostructure variation with themore » laser fluence, F, also evidences an interesting dependence, with a coarsening of the structure morphology as F increases. Our experimental findings demonstrate that direct femtosecond laser ablation with optical vortex beams produces interesting patterns not achievable by the more standard beams with a Gaussian intensity profile. They also suggest that appropriate tuning of the experimental conditions (F, N) can allow generating micro- and/or nano-structured surface for any specific application.« less

Compensation for Distributed Solar. A Survey of Options to Preserve Stakeholder Value

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flores-Espino, Francisco

2015-09-01

Compensation mechanisms for electricity generation systems installed behind the meter are under scrutiny in several jurisdictions in the United States. Legislators in 29 states introduced bills to amend net metering provisions in 2014, and in 33 states in the 2015 legislative session as of August 20, 2015. Some utilities have also sought to increase the revenue they receive from net-metered customers through rate redesign. The circumstances that have triggered the recent push for change include a growing percentage of net-metered customers, potential effects of distributed generation on cost allocation, decreasing photovoltaic (PV) system costs, the challenges of integrating high levelsmore » of solar generation in the distribution network, and increasing pressure on utility business models. This report presents a survey of options to charge and compensate PV customers, as well as options that may preserve utility revenues in scenarios with increased DG. These options could be used as building blocks to create a distributed generation (DG) compensation policy that may preserve the value of the different stakeholders and balance their interests.« less

Magnetoresistance effect of heat generation in a single-molecular spin-valve

NASA Astrophysics Data System (ADS)

Jiang, Feng; Yan, Yonghong; Wang, Shikuan; Yan, Yijing

2016-02-01

Based on non-equilibrium Green's functions' theory and small polaron transformation's technology, we study the heat generation by current through a single-molecular spin-valve. Numerical results indicate that the variation of spin polarization degree can change heat generation effectively, the spin-valve effect happens not only in electrical current but also in heat generation when Coulomb repulsion in quantum dot is smaller than phonon frequency and interestingly, when Coulomb repulsion is larger than phonon frequency, the inverse spin-valve effect appears by sweeping gate voltage and is enlarged with bias increasing. The inverse spin-valve effect will induce the unique heat magnetoresistance effect, which can be modulated from heat-resistance to heat-gain by gate voltage easily.

Investigating Students' Interest in Chemistry through Self-Generated Questions

ERIC Educational Resources Information Center

Demirdogen, Betul; Cakmakci, Gultekin

2014-01-01

This study investigates Turkish students' (age 15 or older) interest in chemistry by analysing 1027 of their self-generated chemistry-related questions, which had been submitted to a popular science magazine. These questions were classified based on the field of interest, the cognitive level of the question, and the stimulating impetus for asking…

Interest in Biology: A Developmental Shift Characterized Using Self-Generated Questions

ERIC Educational Resources Information Center

Baram-Tsabari, Ayelet; Yarden, Anat

2007-01-01

Identifying students' interests in biology can play an important role in improving existing curricula to meet their needs. An analysis of 1,751 self-generated biological questions raised by children, adolescents, and adults yielded data regarding the different age groups' interests in biology. Research limitations and applications for teaching are…

Generation of high-density biskyrmions by electric current

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, Licong; Zhang, Ying; He, Min

Much interest has been focused on the manipulation of magnetic skyrmions, including the generation, annihilation, and motion behaviors, for potential applications in spintronics. We experimentally demonstrate that a high-density Bloch-type biskyrmion lattice in MnNiGa can be generated by applying electric current. It is revealed that the density of biskyrmions can be remarkably increased by increasing the electric current, in contrast to the scattered biskyrmions induced by a magnetic field alone. Furthermore, the transition from the ferromagnetic state to the stripe domain structure can be terminated by the electric current, leading to the biskyrmions dominated residual domain pattern. These biskyrmions inmore » such residual domain structure are extremely stable at zero magnetic and electric fields and can further evolve into the high-density biskyrmion lattice over a temperature range from 100 to 330 K. Finally, our experimental findings open up a new pathway for the generation of skyrmion lattice by electric current manipulation.« less

Generation of high-density biskyrmions by electric current

DOE PAGES

Peng, Licong; Zhang, Ying; He, Min; ...

2017-06-16

Much interest has been focused on the manipulation of magnetic skyrmions, including the generation, annihilation, and motion behaviors, for potential applications in spintronics. We experimentally demonstrate that a high-density Bloch-type biskyrmion lattice in MnNiGa can be generated by applying electric current. It is revealed that the density of biskyrmions can be remarkably increased by increasing the electric current, in contrast to the scattered biskyrmions induced by a magnetic field alone. Furthermore, the transition from the ferromagnetic state to the stripe domain structure can be terminated by the electric current, leading to the biskyrmions dominated residual domain pattern. These biskyrmions inmore » such residual domain structure are extremely stable at zero magnetic and electric fields and can further evolve into the high-density biskyrmion lattice over a temperature range from 100 to 330 K. Finally, our experimental findings open up a new pathway for the generation of skyrmion lattice by electric current manipulation.« less

Focal cryotherapy for prostate cancer.

PubMed

Tsivian, Matvey; Polascik, Thomas J

2010-05-01

Focal therapy for prostate cancer has emerged an interesting concept as a less morbid option for the treatment of localized low-risk disease. Despite the growing interest in focal therapy, this approach has not yet gained sufficient popularity nor provided enough data to be discussed outside the experimental application. Herein we summarize the available data on focal cryotherapy and focus on the targets to be achieved in order to increase the applicability of focal cryotherapy to clinical practice. A cautious approach to candidate selection and generation of solid scientific data that would result in wide consensus on patient selection strategies and follow-up schemes would provide the tools necessary to take the path of focal therapy. Currently available focal cryotherapy data demonstrate excellent short-term results and a favorable quality-of-life profile. Although the future role of focal treatment is debated, a growing amount of science is generated in support of this minimally invasive approach.

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids.

PubMed

Pérez-Areales, Francisco Javier; Betari, Nibal; Viayna, Antonio; Pont, Caterina; Espargaró, Alba; Bartolini, Manuela; De Simone, Angela; Rinaldi Alvarenga, José Fernando; Pérez, Belén; Sabate, Raimon; Lamuela-Raventós, Rosa Maria; Andrisano, Vincenza; Luque, Francisco Javier; Muñoz-Torrero, Diego

2017-06-01

Simultaneous modulation of several key targets of the pathological network of Alzheimer's disease (AD) is being increasingly pursued as a promising option to fill the critical gap of efficacious drugs against this condition. A short series of compounds purported to hit multiple targets of relevance in AD has been designed, on the basis of their distinct basicities estimated from high-level quantum mechanical computations, synthesized, and subjected to assays of inhibition of cholinesterases, BACE-1, and Aβ42 and tau aggregation, of antioxidant activity, and of brain permeation. Using, as a template, a lead rhein-huprine hybrid with an interesting multitarget profile, we have developed second-generation compounds, designed by the modification of the huprine aromatic ring. Replacement by [1,8]-naphthyridine or thieno[3,2-e]pyridine systems resulted in decreased, although still potent, acetylcholinesterase or BACE-1 inhibitory activities, which are more balanced relative to their Aβ42 and tau antiaggregating and antioxidant activities. Second-generation naphthyridine- and thienopyridine-based rhein-huprine hybrids emerge as interesting brain permeable compounds that hit several crucial pathogenic factors of AD.

Eight-Legged Encounters—Arachnids, Volunteers, and Art help to Bridge the Gap between Informal and Formal Science Learning

PubMed Central

Hebets, Eileen A.; Welch-Lazoritz, Melissa; Tisdale, Pawl; Wonch Hill, Trish

2018-01-01

Increased integration and synergy between formal and informal learning environments is proposed to provide multiple benefits to science learners. In an effort to better bridge these two learning contexts, we developed an educational model that employs the charismatic nature of arachnids to engage the public of all ages in science learning; learning that aligns with the Next Generation Science Standards (NGSS Disciplinary Core Ideas associated with Biodiversity and Evolution). We created, implemented, and evaluated a family-focused, interactive science event—Eight-Legged Encounters (ELE)—which encompasses more than twenty modular activities. Volunteers facilitated participant involvement at each activity station and original artwork scattered throughout the event was intended to attract visitors. Initial ELE goals were to increase interest in arachnids and science more generally, among ELE participants. In this study, we tested the efficacy of ELE in terms of (i) activity-specific visitation rates and self-reported interest levels, (ii) the self-reported efficacy of our use of volunteers and original artwork on visitor engagement, and (iii) self-reported increases in interest in both spiders and science more generally. We collected survey data across five ELE events at four museum and zoo sites throughout the Midwest. We found that all activities were successful at attracting visitors and capturing their interest. Both volunteers and artwork were reported to be effective at engaging visitors, though likely in different ways. Additionally, most participants reported increased interest in learning about arachnids and science. In summary, ELE appears effective at engaging the public and piquing their interest. Future work is now required to assess learning outcomes directly, as well as the ability for participants to transfer knowledge gain across learning environments. PMID:29495395

Eight-Legged Encounters-Arachnids, Volunteers, and Art help to Bridge the Gap between Informal and Formal Science Learning.

PubMed

Hebets, Eileen A; Welch-Lazoritz, Melissa; Tisdale, Pawl; Wonch Hill, Trish

2018-02-26

Increased integration and synergy between formal and informal learning environments is proposed to provide multiple benefits to science learners. In an effort to better bridge these two learning contexts, we developed an educational model that employs the charismatic nature of arachnids to engage the public of all ages in science learning; learning that aligns with the Next Generation Science Standards (NGSS Disciplinary Core Ideas associated with Biodiversity and Evolution). We created, implemented, and evaluated a family-focused, interactive science event- Eight-Legged Encounters (ELE )-which encompasses more than twenty modular activities. Volunteers facilitated participant involvement at each activity station and original artwork scattered throughout the event was intended to attract visitors. Initial ELE goals were to increase interest in arachnids and science more generally, among ELE participants. In this study, we tested the efficacy of ELE in terms of (i) activity-specific visitation rates and self-reported interest levels, (ii) the self-reported efficacy of our use of volunteers and original artwork on visitor engagement, and (iii) self-reported increases in interest in both spiders and science more generally. We collected survey data across five ELE events at four museum and zoo sites throughout the Midwest. We found that all activities were successful at attracting visitors and capturing their interest. Both volunteers and artwork were reported to be effective at engaging visitors, though likely in different ways. Additionally, most participants reported increased interest in learning about arachnids and science. In summary, ELE appears effective at engaging the public and piquing their interest. Future work is now required to assess learning outcomes directly, as well as the ability for participants to transfer knowledge gain across learning environments.

Content-based image exploitation for situational awareness

NASA Astrophysics Data System (ADS)

Gains, David

2008-04-01

Image exploitation is of increasing importance to the enterprise of building situational awareness from multi-source data. It involves image acquisition, identification of objects of interest in imagery, storage, search and retrieval of imagery, and the distribution of imagery over possibly bandwidth limited networks. This paper describes an image exploitation application that uses image content alone to detect objects of interest, and that automatically establishes and preserves spatial and temporal relationships between images, cameras and objects. The application features an intuitive user interface that exposes all images and information generated by the system to an operator thus facilitating the formation of situational awareness.

Blog Attack: New Teaching Strategies to Engage Today's College Students

ERIC Educational Resources Information Center

Castro, Denise

2012-01-01

The growing need to match pedagogy with the evolving needs of a new generation of learners has stirred and interest in Web 2.0 Blogging can bring a surprisingly rich experience to class projects by increasing collaboration between students and teacher. As a teaching tool, blogging can bring greater complexity to learning that would have otherwise…

Moving Beyond Access: College Success for Low-Income, First-Generation Students

ERIC Educational Resources Information Center

Engle, Jennifer; Tinto, Vincent

2008-01-01

Given the pressure to remain competitive in the global knowledge economy, it is in the shared national interest to act to increase the number of students who not only enter college, but more importantly, earn their degrees. Changing national demographics requires a refocus of efforts on improving postsecondary access and success among populations…

Multiple Frequency Parametric Sonar

DTIC Science & Technology

2015-09-28

300003 1 MULTIPLE FREQUENCY PARAMETRIC SONAR STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein may be manufactured and...a method for increasing the bandwidth of a parametric sonar system by using multiple primary frequencies rather than only two primary frequencies...2) Description of Prior Art [0004] Parametric sonar generates narrow beams at low frequencies by projecting sound at two distinct primary

Evaluation of an automated room decontamination device using aerosolized peracetic acid.

PubMed

Mana, Thriveen S C; Sitzlar, Brett; Cadnum, Jennifer L; Jencson, Annette L; Koganti, Sreelatha; Donskey, Curtis J

2017-03-01

Because manual cleaning is often suboptimal, there is increasing interest in use of automated devices for room decontamination. We demonstrated that an ultrasonic room fogging system that generates submicron droplets of peracetic acid and hydrogen peroxide eliminated Clostridium difficile spores and vegetative pathogens from exposed carriers in hospital rooms and adjacent bathrooms. Published by Elsevier Inc.

Modeling Japan-South Seas trade in forest products.

Treesearch

J.R. Vincent

1987-01-01

The international trade of forest products has generated increasing research interest, yet experience with modeling such trade is limited. Primary issues include the effects of trade barriers and exchange rates on trade patterns and national welfare. This paper attempts to add to experience by modeling hardwood log, lumber, and plywood trade in a region that has been...

RiPLE: Recommendation in Peer-Learning Environments Based on Knowledge Gaps and Interests

ERIC Educational Resources Information Center

Khosravi, Hassan; Kitto, Kirsty; Cooper, Kendra

2017-01-01

Various forms of Peer-Learning Environments are increasingly being used in post-secondary education, often to help build repositories of student generated learning objects. However, large classes can result in an extensive repository, which can make it more challenging for students to search for suitable objects that both reflect their interests…

Partnering with Employers to Promote Job Advancement for Low-Skill Individuals

ERIC Educational Resources Information Center

Martinson, Karin

2010-01-01

The current economic climate in the United States and the difficulty employers face in hiring and maintaining a skilled workforce in an increasingly competitive and global economy have generated interest in developing and promoting policies and programs that can most effectively help low-skill individuals gain job skills and move up the economic…

Narcissism, Exploitative Attitudes, and Academic Dishonesty: An Exploratory Investigation of Reality versus Myth

ERIC Educational Resources Information Center

Menon, Mohan K.; Sharland, Alex

2011-01-01

Renewed interest in the effects of narcissism in the media has generated a closer examination of the phenomenon. This coupled with an increase in academic misbehavior among both high school and university students has provided an opportunity to scrutinize the effects of narcissism on attitudes toward academic dishonesty. The authors investigated…

Determination of humic and fulvic acids in commercial solid and liquid humic products by alkaline extraction and gravimetric determination

USDA-ARS?s Scientific Manuscript database

Increased use of humic substances in agriculture has generated intense interest among producers, consumers, and regulators for an accurate and reliable method for quantification of humic (HA) and fulvic acids (FA) in raw ores and products. Here we present a thoroughly validated method, the Humic Pro...

Measurement Activities for Increasing Student Curiosity for Animal and Space Topics.

ERIC Educational Resources Information Center

Rule, Audrey C., Ed.

This document presents a resource for elementary teachers in the form of a collection of facts and measurements of animals and planets to be used in generating student interest for these different topics. It is suggested that the teacher make an overhead transparency of the measurements related to the current topic, then have students guess at…

To Activate English Learning: Listen and Speak in Real Life Context with an AR Featured U-Learning System

ERIC Educational Resources Information Center

Ho, Shu-Chun; Hsieh, Sheng-Wen; Sun, Pei-Chen; Chen, Cheng-Ming

2017-01-01

The increasing advance of mobile devices and wireless technologies has generated great interest in ubiquitous learning (u-learning) among academia, practitioners, and policy makers. However, design elements that incorporate learning styles and learning strategies into u-learning system applications in English as a Foreign Language (EFL) education…

The Promotion of the Youth Olympic Games: A Greek Perspective

ERIC Educational Resources Information Center

Judge, Lawrence W.; Kantzidou, Eleni D.; Bellar, David; Peterson, Jeffrey; Gilreath, Erin; Surber, Karin

2011-01-01

One of the International Olympic Committee's (IOC) objectives is to reignite interest in Olympic sports in the midst of a generation of adolescents who have become increasingly overweight and inactive. In an effort to accomplish this objective, the Youth Olympic Games (YOG) were created, and the inaugural event was held in the summer of 2010. The…

Comparative Modeling of Proteins: A Method for Engaging Students' Interest in Bioinformatics Tools

ERIC Educational Resources Information Center

Badotti, Fernanda; Barbosa, Alan Sales; Reis, André Luiz Martins; do Valle, Ítalo Faria; Ambrósio, Lara; Bitar, Mainá

2014-01-01

The huge increase in data being produced in the genomic era has produced a need to incorporate computers into the research process. Sequence generation, its subsequent storage, interpretation, and analysis are now entirely computer-dependent tasks. Universities from all over the world have been challenged to seek a way of encouraging students to…

Enhanced microbial coalbed methane generation: A review of research, commercial activity, and remaining challenges

USGS Publications Warehouse

Ritter, Daniel J.; Vinson, David S.; Barnhart, Elliott P.; Akob, Denise M.; Fields, Matthew W.; Cunningham, Al B.; Orem, William H.; McIntosh, Jennifer C.

2015-01-01

Coalbed methane (CBM) makes up a significant portion of the world’s natural gas resources. The discovery that approximately 20% of natural gas is microbial in origin has led to interest in microbially enhanced CBM (MECoM), which involves stimulating microorganisms to produce additional CBM from existing production wells. This paper reviews current laboratory and field research on understanding processes and reservoir conditions which are essential for microbial CBM generation, the progress of efforts to stimulate microbial methane generation in coal beds, and key remaining knowledge gaps. Research has been primarily focused on identifying microbial communities present in areas of CBM generation and attempting to determine their function, in-situ reservoir conditions that are most favorable for microbial CBM generation, and geochemical indicators of metabolic pathways of methanogenesis (i.e., acetoclastic or hydrogenotrophic methanogenesis). Meanwhile, researchers at universities, government agencies, and companies have focused on four primary MECoM strategies: 1) microbial stimulation (i.e., addition of nutrients to stimulate native microbes); 2) microbial augmentation (i.e., addition of microbes not native to or abundant in the reservoir of interest); 3) physically increasing microbial access to coal and distribution of amendments; and 4) chemically increasing the bioavailability of coal organics. Most companies interested in MECoM have pursued microbial stimulation: Luca Technologies, Inc., successfully completed a pilot scale field test of their stimulation strategy, while two others, Ciris Energy and Next Fuel, Inc., have undertaken smaller scale field tests. Several key knowledge gaps remain that need to be addressed before MECoM strategies can be implemented commercially. Little is known about the bacterial community responsible for coal biodegradation and how these microorganisms may be stimulated to enhance microbial methanogenesis. In addition, research is needed to understand what fraction of coal is available for biodegradation, and methods need to be developed to determine the extent of in-situ coal biodegradation by MECoM processes for monitoring changes to coal quality. Questions also remain about how well field-scale pilot tests will scale to commercial production, how often amendments will need to be added to maintain new methane generation, and how well MECoM strategies transfer between coal basins with different formation water geochemistries and coal ranks. Addressing these knowledge gaps will be key in determining the feasibility and commercial viability of MECoM technology.

The Advanced Gamma-Ray Imaging System (AGIS)

NASA Astrophysics Data System (ADS)

Williams, David A.; AGIS Collaboration

2009-01-01

The spectacular astrophysical discoveries made by the present generation of ground-based gamma-ray observatories have opened a new era in the exploration of the highest energy Universe and have conclusively established the field of very-high-energy (VHE) astronomy, covering the energy regime above about 50 GeV. The detection of nearly 100 galactic and extragalactic sources has generated considerable interest in the astronomy, astrophysics and particle physics communities and has stimulated ambitious ideas and plans for future gamma-ray observatories. AGIS is a concept for a next generation VHE observatory with a collecting area on the scale of a square kilometer being developed by an international collaboration. It would have significantly improved angular and energy resolution, increased field of view, and an order of magnitude increase in sensitivity over existing space or ground-based instruments in the energy range 40 GeV to 100 TeV. The scientific motivations and R&D roadmap for AGIS will be discussed.

The biochemistry of hematopoietic stem cell development.

PubMed

Kaimakis, P; Crisan, M; Dzierzak, E

2013-02-01

The cornerstone of the adult hematopoietic system and clinical treatments for blood-related disease is the cohort of hematopoietic stem cells (HSC) that is harbored in the adult bone marrow microenvironment. Interestingly, this cohort of HSCs is generated only during a short window of developmental time. In mammalian embryos, hematopoietic progenitor and HSC generation occurs within several extra- and intraembryonic microenvironments, most notably from 'hemogenic' endothelial cells lining the major vasculature. HSCs are made through a remarkable transdifferentiation of endothelial cells to a hematopoietic fate that is long-lived and self-renewable. Recent studies are beginning to provide an understanding of the biochemical signaling pathways and transcription factors/complexes that promote their generation. The focus of this review is on the biochemistry behind the generation of these potent long-lived self-renewing stem cells of the blood system. Both the intrinsic (master transcription factors) and extrinsic regulators (morphogens and growth factors) that affect the generation, maintenance and expansion of HSCs in the embryo will be discussed. The generation of HSCs is a stepwise process involving many developmental signaling pathways, morphogens and cytokines. Pivotal hematopoietic transcription factors are required for their generation. Interestingly, whereas these factors are necessary for HSC generation, their expression in adult bone marrow HSCs is oftentimes not required. Thus, the biochemistry and molecular regulation of HSC development in the embryo are overlapping, but differ significantly from the regulation of HSCs in the adult. HSC numbers for clinical use are limiting, and despite much research into the molecular basis of HSC regulation in the adult bone marrow, no panel of growth factors, interleukins and/or morphogens has been found to sufficiently increase the number of these important stem cells. An understanding of the biochemistry of HSC generation in the developing embryo provides important new knowledge on how these complex stem cells are made, sustained and expanded in the embryo to give rise to the complete adult hematopoietic system, thus stimulating novel strategies for producing increased numbers of clinically useful HSCs. This article is part of a Special Issue entitled Biochemistry of Stem Cells. Copyright © 2012 Elsevier B.V. All rights reserved.

Forecasting Electric Power Generation of Photovoltaic Power System for Energy Network

NASA Astrophysics Data System (ADS)

Kudo, Mitsuru; Takeuchi, Akira; Nozaki, Yousuke; Endo, Hisahito; Sumita, Jiro

Recently, there has been an increase in concern about the global environment. Interest is growing in developing an energy network by which new energy systems such as photovoltaic and fuel cells generate power locally and electric power and heat are controlled with a communications network. We developed the power generation forecast method for photovoltaic power systems in an energy network. The method makes use of weather information and regression analysis. We carried out forecasting power output of the photovoltaic power system installed in Expo 2005, Aichi Japan. As a result of comparing measurements with a prediction values, the average prediction error per day was about 26% of the measured power.

Organic acid-tolerant microorganisms and uses thereof for producing organic acids

DOEpatents

Pfleger, Brian Frederick; Begemann, Matthew Brett

2014-05-06

Organic acid-tolerant microorganisms and methods of using same. The organic acid-tolerant microorganisms comprise modifications that reduce or ablate AcsA activity or AcsA homolog activity. The modifications increase tolerance of the microorganisms to such organic acids as 3-hydroxypropionic acid (3HP), acrylic acid, and propionic acid. Further modifications to the microorganisms such as increasing expression of malonyl-CoA reductase and/or acetyl-CoA carboxylase provide or increase the ability of the microorganisms to produce 3HP. Methods of generating an organic acid with the modified microorganisms are provided. Methods of using acsA or homologs thereof as counter-selectable markers include replacing acsA or homologs thereof in cells with genes of interest and selecting for the cells comprising the genes of interest with amounts of organic acids effective to inhibit growth of cells harboring acsA or the homologs.

Increasing Interest of Mass Communication Media and the General Public in the Distribution of Tweets About Mental Disorders: Observational Study.

PubMed

Alvarez-Mon, Miguel Angel; Asunsolo Del Barco, Angel; Lahera, Guillermo; Quintero, Javier; Ferre, Francisco; Pereira-Sanchez, Victor; Ortuño, Felipe; Alvarez-Mon, Melchor

2018-05-28

The contents of traditional communication media and new internet social media reflect the interests of society. However, certain barriers and a lack of attention towards mental disorders have been previously observed. The objective of this study is to measure the relevance of influential American mainstream media outlets for the distribution of psychiatric information and the interest generated in these topics among their Twitter followers. We investigated tweets generated about mental health conditions and diseases among 15 mainstream general communication media outlets in the United States of America between January 2007 and December 2016. Our study strategy focused on identifying several psychiatric terms of primary interest. The number of retweets generated from the selected tweets was also investigated. As a control, we examined tweets generated about the main causes of death in the United States of America, the main chronic neurological degenerative diseases, and HIV. In total, 13,119 tweets about mental health disorders sent by the American mainstream media outlets were analyzed. The results showed a heterogeneous distribution but preferential accumulation for a select number of conditions. Suicide and gender dysphoria accounted for half of the number of tweets sent. Variability in the number of tweets related to each control disease was also found (5998). The number of tweets sent regarding each different psychiatric or organic disease analyzed was significantly correlated with the number of retweets generated by followers (1,030,974 and 424,813 responses to mental health disorders and organic diseases, respectively). However, the probability of a tweet being retweeted differed significantly among the conditions and diseases analyzed. Furthermore, the retweeted to tweet ratio was significantly higher for psychiatric diseases than for the control diseases (odds ratio 1.11, CI 1.07-1.14; P<.001). American mainstream media outlets and the general public demonstrate a preferential interest for psychiatric diseases on Twitter. The heterogeneous weights given by the media outlets analyzed to the different mental health disorders and conditions are reflected in the responses of Twitter followers. ©Miguel Angel Alvarez-Mon, Angel Asunsolo del Barco, Guillermo Lahera, Javier Quintero, Francisco Ferre, Victor Pereira-Sanchez, Felipe Ortuño, Melchor Alvarez-Mon. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 28.05.2018.

Conflicts of interest in Australia's IVF industry: an empirical analysis and call for action.

PubMed

Blakely, Brette; Williams, Jane; Mayes, Christopher; Kerridge, Ian; Lipworth, Wendy

2017-11-01

In Australia, the growing assisted reproductive technologies (ART) industry has recently received some public criticism. Much of this criticism centres on the concern that doctors are increasingly motivated by profit, rather than patient interests. These concerns appear to suggest that the growing business of ART generates conflicts of interest (COI) for clinicians. While media reports may be rhetorically compelling, claims that ART practice is distorted by COI must be supported by empirical evidence. This preliminary study sought to engage with people involved with the ART industry and map out their concerns related to COI in ART. A small convenience sample of eight professionals was interviewed. Here, we present the major themes uncovered, including a richer understanding of the 'interests' of various parties involved in Australian ART. We then propose a strategy for how this topic could be constructively explored.

A flow visualization study of single-arm sculling movement emulating cephalopod thrust generation

NASA Astrophysics Data System (ADS)

Kazakidi, Asimina; Gnanamanickam, Ebenezer P.; Tsakiris, Dimitris P.; Ekaterinaris, John A.

2014-11-01

In addition to jet propulsion, octopuses use arm-swimming motion as an effective means of generating bursts of thrust, for hunting, defense, or escape. The individual role of their arms, acting as thrust generators during this motion, is still under investigation, in view of an increasing robotic interest for alternative modes of propulsion, inspired by the octopus. Computational studies have revealed that thrust generation is associated with complex vortical flow patterns in the wake of the moving arm, however further experimental validation is required. Using the hydrogen bubble technique, we studied the flow disturbance around a single octopus-like robotic arm, undergoing two-stroke sculling movements in quiescent fluid. Although simplified, sculling profiles have been found to adequately capture the fundamental kinematics of the octopus arm-swimming behavior. In fact, variation of the sculling parameters alters considerably the generation of forward thrust. Flow visualization revealed the generation of complex vortical structures around both rigid and compliant arms. Increased disturbance was evident near the tip, particularly at the transitional phase between recovery and power strokes. These results are in good qualitative agreement with computational and robotic studies. Work funded by the ESF-GSRT HYDRO-ROB Project PE7(281).

A Stirling engine for use with lower quality fuels

NASA Astrophysics Data System (ADS)

Paul, Christopher J.

There is increasing interest in using renewable fuels from biomass or alternative fuels such as municipal waste to reduce the need for fossil based fuels. Due to the lower heating values and higher levels of impurities, small scale electricity generation is more problematic. Currently, there are not many technologically mature options for small scale electricity generation using lower quality fuels. Even though there are few manufacturers of Stirling engines, the history of their development for two centuries offers significant guidance in developing a viable small scale generator set using lower quality fuels. The history, development, and modeling of Stirling engines were reviewed to identify possible model and engine configurations. A Stirling engine model based on the finite volume, ideal adiabatic model was developed. Flow dissipation losses are shown to need correcting as they increase significantly at low mean engine pressure and high engine speed. The complete engine including external components was developed. A simple yet effective method of evaluating the external heat transfer to the Stirling engine was created that can be used with any second order Stirling engine model. A derivative of the General Motors Ground Power Unit 3 was designed. By significantly increasing heater, cooler and regenerator size at the expense of increased dead volume, and adding a combustion gas recirculation, a generator set with good efficiency was designed.

New Technology for Microfabrication and Testing of a Thermoelectric Device for Generating Mobile Electrical Power

NASA Technical Reports Server (NTRS)

Prasad, Narasimha S.; Taylor, Patrick J.; Trivedi, Sudhir B.; Kutcher, Susan

2012-01-01

Thermoelectric (TE) power generation is an increasingly important power generation technology. Major advantages include: no moving parts, low-weight, modularity, covertness/silence, high power density, low amortized cost, and long service life with minimum or no required maintenance. Despite low efficiency of power generation, there are many specialized needs for electrical power that TE technologies can uniquely and successfully address. Recent advances in thermoelectric materials technology have rekindled acute interest in thermoelectric power generation. We have developed single crystalline n- and p- type PbTe crystals and are also, developing PbTe bulk nanocomposites using PbTe nano powders and emerging filed assisted sintering technology (FAST). We will discuss the materials requirements for efficient thermoelectric power generation using waste heat at intermediate temperature range (6500 to 8500 K). We will present our recent results on production of n- and p- type PbTe crystals and their thermoelectric characterization. Relative characteristics and performance of PbTe bulk single crystals and nano composites for thermoelectric power generation will be discussed.

Evidence-based health policy: three generations of reform in Mexico.

PubMed

Frenk, Julio; Sepúlveda, Jaime; Gómez-Dantés, Octavio; Knaul, Felicia

2003-11-15

The Mexican health system has evolved through three generations of reform. The creation of the Ministry of Health and the main social security agency in 1943 marked the first generation of health reforms. In the late 1970s, a second generation of reforms was launched around the primary health-care model. Third-generation reforms favour systemic changes to reorganise the system through the horizontal integration of basic functions-stewardship, financing, and provision. The stability of leadership in the health sector is emphasised as a key element that allowed for reform during the past 60 years. Furthermore, there has been a transition in the second generation of reforms to a model that is increasingly based on evidence; this has been intensified and extended in the third generation of reforms. We also examine policy developments that will provide social protection in health for all. These developments could be of interest for countries seeking to provide their citizens with universal access to health care that incorporates equity, quality, and financial protection.

How Safe Do Students Feel at School and while Traveling to School? A Comparative Look at Israel and the United States

ERIC Educational Resources Information Center

Addington, Lynn A.; Yablon, Yaacov B.

2011-01-01

Despite increased interest in studying school violence, much less attention has been given to examining students' fear of experiencing this violence. A better understanding is important, because fear of victimization can generate negative academic consequences for the individual student and larger school environment. To explore students' fear, our…

The Promotion and Perception of the Youth Olympic Games: A Korean Perspective

ERIC Educational Resources Information Center

Judge, Lawrence W.; Lee, Don; Surber, Karin; Bellar, David; Petersen, Jeffrey; Ivan, Emese; Kim, Hyeon Jung

2013-01-01

The Youth Olympic Games (YOG) was launched in part to reignite interest in Olympic sports in the midst of a generation of increasingly overweight and inactive adolescents. But since the initial announcement of the YOG by the International Olympic Committee in 2007, this new third addition to the Olympic family of events has provoked response from…

Description and Preliminary Evaluation of a Program for Improving Chemistry Learning in High School Students

ERIC Educational Resources Information Center

Armbrecht, Jose´ Pen~aranda; Arago´n-Muriel, Alberto; Micolta, Germania

2014-01-01

High school students have had some difficulties in understanding chemistry due to traditional ways of teaching this specific science. It is important to improve teaching methods that increase student motivation, not only to enhance their capacity for understanding, but also to generate a greater level of interest in the study of chemistry for…

Bridging Community Generational Gaps through Experiential Learning: A College Nursing Student Practicum for Elderly Patients

ERIC Educational Resources Information Center

Pate, Jane D.

2013-01-01

At the study site, an elder care practicum was adopted after nursing students demonstrated a lack of interest in the well-being of elderly patients. The purpose of the study was to determine if there was a change in college nursing students' attitudes toward nursing home residents as a result of increased intergenerational exposure following an…

The Effect of a Climate Change Monitoring Program on Students' Knowledge and Perceptions of STEAM Education in Korea

ERIC Educational Resources Information Center

Jeong, Sophia; Kim, Hyoungbum

2015-01-01

Korea has recently started to implement a STEM-like approach in K-12 education, titled STEAM (Science, Technology, Engineering, Arts, and Mathematics) curriculum, to educate the next generation of students to become creative innovators. As this approach has been shown to increase educational success, it is vital to prepare and develop interest in…

Introduction to nursing. Creative strategies for generating interest in the major.

PubMed

Kopp, A M

1999-01-01

Beginning nursing students have a limited understanding of nursing as a major and a profession. Evaluation of previous Introduction to Nursing courses led faculty to a redesign which included classroom exercises and assignments that actively engage students in a wider variety of experiences. Increased student involvement had the effect of presenting a more realistic picture of nursing as a profession.

Concepts of integrated satellite surveys. [thematic mapping of land use in Ethiopia, Sudan, and Morocco

NASA Technical Reports Server (NTRS)

Howard, J. A.

1974-01-01

The United Nations initially contracted with NASA to carry out investigations in three countries; but now as the result of rapidly increasing interest, ERTS imagery has been/is being used in 7 additional projects related to agriculture, forestry, land-use, soils, landforms and hydrology. Initially the ERTS frames were simply used to provide a synoptic view of a large area of a developing country as a basis to regional surveys. From this, interest has extended to using reconstituted false color imagery and latterly, in co-operation with Purdue University, the use of computer generated false color mosaics and computer generated large scale maps. As many developing countries are inadequately mapped and frequently rely on outdated maps, the ERTS imagery is considered to provide a very wide spectrum of valuable data. Thematic maps can be readily prepared at a scale of 1:250,000 using standard NASA imagery. These provide coverage of areas not previously mapped and provide supplementary information and enable existing maps to be up-dated. There is also increasing evidence that ERTS imagery is useful for temporal studies and for providing a new dimension in integrated surveys.

The concentration principle applied to spaceborne solar arrays. Application to the coorbiting platform mission: Studies synthesis

NASA Astrophysics Data System (ADS)

Laget, R.

1986-01-01

Studies that led to selection of the distributed concentration biplane concept for the solar cell generator to be flown on the coorbiting platform mission, and the major characteristics of such a spaceborne solar array are summarized. It is concluded that there is not a considerable interest in concentration either for array area reduction or cost reduction, although improvements of 15% for both domains are feasible. Only predevelopment activities to verify concentrator performances and system studies to assess respective importance of cost and area saving may increase the level of interest of concentrator solar arrays for this kind of mission.

[People's interest in health information].

PubMed

Horch, K; Wirz, J

2005-11-01

Well-informed citizens and patients regard health policy innovations as a key element when it comes to reforms in the health service--both in health economics and with regard to prevention issues. We evaluated the data provided by the 2003 Telephone Health Survey (GSTel03) to examine demographic and social distinctions in the use of different information sources. At the same time we examined whether there are any population-related differences in people's interest in health information depending on their levels of health awareness, attitudes to prevention and related modes of behaviour. The data generated by the survey show that there is considerable interest in health-related topics. Only 2% of the people questioned used no information sources for this purpose. In addition to more traditional media (books, newspapers, information from pharmacies), information provided by health insurance companies and via the Internet is becoming increasingly important. With the exception of the Internet, all other sources of information are used more frequently by women than by men, and demand for most of the information media increases with age. The frequency of information use and the number of different media used increase from the lower to the upper strata of society. As far as selected variables of health-related behaviour are concerned (smoking, sport, alcohol), the results show a link between a more positive attitude to health and a greater interest in information.

The combined value of wind and solar power forecasting improvements and electricity storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hodge, Bri-Mathias; Brancucci Martinez-Anido, Carlo; Wang, Qin

As the penetration rates of variable renewable energy increase, the value of power systems operation flexibility technology options, such as renewable energy forecasting improvements and electricity storage, is also assumed to increase. In this work, we examine the value of these two technologies, when used independently and concurrently, for two real case studies that represent the generation mixes for the California and Midcontinent Independent System Operators (CAISO and MISO). Since both technologies provide additional system flexibility they reduce operational costs and renewable curtailment for both generation mixes under study. Interestingly, the relative impacts are quite similar when both technologies aremore » used together. Though both flexibility options can solve some of the same issues that arise with high penetration levels of renewables, they do not seem to significantly increase or decrease the economic potential of the other technology.« less

Durability Challenges for Next Generation of Gas Turbine Engine Materials

NASA Technical Reports Server (NTRS)

Misra, Ajay K.

2012-01-01

Aggressive fuel burn and carbon dioxide emission reduction goals for future gas turbine engines will require higher overall pressure ratio, and a significant increase in turbine inlet temperature. These goals can be achieved by increasing temperature capability of turbine engine hot section materials and decreasing weight of fan section of the engine. NASA is currently developing several advanced hot section materials for increasing temperature capability of future gas turbine engines. The materials of interest include ceramic matrix composites with 1482 - 1648 C temperature capability, advanced disk alloys with 815 C capability, and low conductivity thermal barrier coatings with erosion resistance. The presentation will provide an overview of durability challenges with emphasis on the environmental factors affecting durability for the next generation of gas turbine engine materials. The environmental factors include gaseous atmosphere in gas turbine engines, molten salt and glass deposits from airborne contaminants, impact from foreign object damage, and erosion from ingestion of small particles.

The combined value of wind and solar power forecasting improvements and electricity storage

DOE PAGES

Hodge, Bri-Mathias; Brancucci Martinez-Anido, Carlo; Wang, Qin; ...

2018-02-12

As the penetration rates of variable renewable energy increase, the value of power systems operation flexibility technology options, such as renewable energy forecasting improvements and electricity storage, is also assumed to increase. In this work, we examine the value of these two technologies, when used independently and concurrently, for two real case studies that represent the generation mixes for the California and Midcontinent Independent System Operators (CAISO and MISO). Since both technologies provide additional system flexibility they reduce operational costs and renewable curtailment for both generation mixes under study. Interestingly, the relative impacts are quite similar when both technologies aremore » used together. Though both flexibility options can solve some of the same issues that arise with high penetration levels of renewables, they do not seem to significantly increase or decrease the economic potential of the other technology.« less

Microwave Memristive-like Nonlinearity in a Dielectric Metamaterial

NASA Astrophysics Data System (ADS)

Wu, Hongya; Zhou, Ji; Lan, Chuwen; Guo, Yunsheng; Bi, Ke

2014-06-01

Memristor exhibit interesting and valuable circuit properties and have thus become the subject of increasing scientific interest. Scientists wonder if they can conceive a microwave memristor that behaves as a memristor operating with electromagnetic fields. Here, we report a microwave memristive-like nonlinear phenomenon at room temperature in dielectric metamaterials consisting of CaTiO3-ZrO2 ceramic dielectric cubes. Hysteretic transmission-incident field power loops (similar to the hysteretic I-V loop of memristor which is the fingerprint of memristor) with various characteristics were systematically observed in the metamaterials, which exhibited designable microwave memristive-like behavior. The effect is attributed to the decreasing permittivity of the dielectric cubes with the increasing temperature generated by the interaction between the electromagnetic waves and the dielectric cubes. This work demonstrates the feasibility of fabrication transient photonic memristor at microwave frequencies with metamaterials.

Atmospheric data access for the geospatial user community

NASA Astrophysics Data System (ADS)

van de Vegte, John; Som de Cerff, Wim-Jan; van den Oord, Gijsbertus H. J.; Sluiter, Raymond; van der Neut, Ian A.; Plieger, Maarten; van Hees, Richard M.; de Jeu, Richard A. M.; Schaepman, Michael E.; Hoogerwerf, Marc R.; Groot, Nikée E.; Domenico, Ben; Nativi, Stefano; Wilhelmi, Olga V.

2007-10-01

Historically the atmospheric and meteorological communities are separate worlds with their own data formats and tools for data handling making sharing of data difficult and cumbersome. On the other hand, these information sources are becoming increasingly of interest outside these communities because of the continuously improving spatial and temporal resolution of e.g. model and satellite data and the interest in historical datasets. New user communities that use geographically based datasets in a cross-domain manner are emerging. This development is supported by the progress made in Geographical Information System (GIS) software. The current GIS software is not yet ready for the wealth of atmospheric data, although the faint outlines of new generation software are already visible: support of HDF, NetCDF and an increasing understanding of temporal issues are only a few of the hints.

A neural mass model of basal ganglia nuclei simulates pathological beta rhythm in Parkinson's disease

NASA Astrophysics Data System (ADS)

Liu, Fei; Wang, Jiang; Liu, Chen; Li, Huiyan; Deng, Bin; Fietkiewicz, Chris; Loparo, Kenneth A.

2016-12-01

An increase in beta oscillations within the basal ganglia nuclei has been shown to be associated with movement disorder, such as Parkinson's disease. The motor cortex and an excitatory-inhibitory neuronal network composed of the subthalamic nucleus (STN) and the external globus pallidus (GPe) are thought to play an important role in the generation of these oscillations. In this paper, we propose a neuron mass model of the basal ganglia on the population level that reproduces the Parkinsonian oscillations in a reciprocal excitatory-inhibitory network. Moreover, it is shown that the generation and frequency of these pathological beta oscillations are varied by the coupling strength and the intrinsic characteristics of the basal ganglia. Simulation results reveal that increase of the coupling strength induces the generation of the beta oscillation, as well as enhances the oscillation frequency. However, for the intrinsic properties of each nucleus in the excitatory-inhibitory network, the STN primarily influences the generation of the beta oscillation while the GPe mainly determines its frequency. Interestingly, describing function analysis applied on this model theoretically explains the mechanism of pathological beta oscillations.

Individual, Situational and Topic Interest in Geoscience Among 11- And 12-Year-Old Children

ERIC Educational Resources Information Center

Trend, Roger

2005-01-01

All interest necessarily links the person with the external environment: the object/s of interest. Research into children's interests is examined in the context of a rapidly-expanding literature which has generated several powerful concepts in recent decades, notably "individual interest", "situational interest" and "topic interest". The first is…

Numerical study of entropy generation in MHD water-based carbon nanotubes along an inclined permeable surface

NASA Astrophysics Data System (ADS)

Soomro, Feroz Ahmed; Rizwan-ul-Haq; Khan, Z. H.; Zhang, Qiang

2017-10-01

Main theme of the article is to examine the entropy generation analysis for the magneto-hydrodynamic mixed convection flow of water functionalized carbon nanotubes along an inclined stretching surface. Thermophysical properties of both particles and working fluid are incorporated in the system of governing partial differential equations. Rehabilitation of nonlinear system of equations is obtained via similarity transformations. Moreover, solutions of these equations are further utilized to determine the volumetric entropy and characteristic entropy generation. Solutions of governing boundary layer equations are obtained numerically using the finite difference method. Effects of two types of carbon nanotubes, namely, single-wall carbon nanotubes (SWCNTs) and multi-wall carbon nanotubes (MWCNTs) with water as base fluid have been analyzed over the physical quantities of interest, namely, surface skin friction, heat transfer rate and entropy generation coefficients. Influential results of velocities, temperature, entropy generation and isotherms are plotted against the emerging parameter, namely, nanoparticle fraction 0≤φ ≤ 0.2, thermal convective parameter 0≤ λ ≤ 5, Hartmann number 0≤ M≤ 2, suction/injection parameter -1≤ S≤ 1, and Eckert number 0≤ Ec ≤ 2. It is finally concluded that skin friction increases due to the increase in the magnetic parameter, suction/injection and nanoparticle volume fraction, whereas the Nusselt number shows an increasing trend due to the increase in the suction parameter, mixed convection parameter and nanoparticle volume fraction. Similarly, entropy generation shows an opposite behavior for the Hartmann number and mixed convection parameter for both single-wall and multi-wall carbon nanotubes.

Power play in the supercontinuum spectra of saturable nonlinear media

NASA Astrophysics Data System (ADS)

Nithyanandan, K.; Vasantha Jayakantha Raja, R.; Porsezian, K.

2014-04-01

We investigate the role of pump power in the generation of supercontinua spectra induced by modulational instability (MI) in saturable nonlinear media (SNL). First, we analyze the dynamics of MI in the SNL using linear stability analysis. We then deal with the generation of a broadband spectrum by virtue of the instability process, and identify the unique behavior of MI in the SNL system. Unlike the case of Kerr-type nonlinearity, the so-called critical modulational frequency (CMF) does not monotonically increase, but behaves in a unique way, such that the increase in power increases the CMF up to the saturation power, and a further increase in power decreases the CMF. This behavior is identified to be unusual in the context of MI and thus makes the study of MI and supercontinuum generation (SCG) of interest. In order to confirm the above stated behavior in relation to SCG, we numerically analyzed the SCG using a split-step Fourier method, and the results confirm that at input power equal to saturation power, phase matching occurs at a short distance relative to other power levels and leads to a maximum enhancement of SCG in certain SNL materials.

"I Don't Think I Could, You Know, Just Teach without Any Emotion": Exploring the Nature and Origin of University Teachers' Emotions

ERIC Educational Resources Information Center

Hagenauer, Gerda; Volet, Simone

2014-01-01

This article addresses the issue of university teachers' emotions generated through teaching and interacting with students. While research on school teachers' emotions is on the increase, interest in the significance of university teachers' emotions is still limited. In light of the growing attention given to the quality of university teaching…

Are International Students Cash Cows? Examining the Relationship between New International Undergraduate Enrollments and Institutional Revenue at Public Colleges and Universities in the US

ERIC Educational Resources Information Center

Cantwell, Brendan

2015-01-01

There has been growing interest in the business of international education. It is often assumed that universities seek international students as a means of generating revenue. The broad purpose of this study was to understand the effects of increased international student enrollment on net tuition revenue. Informed by resource dependency and…

Sequence to Sequence - Video to Text

DTIC Science & Technology

2015-12-11

Saenko, and S. Guadarrama. Generating natural-language video descriptions using text - mined knowledge. In AAAI, July 2013. 2 [20] P. Kuznetsova, V...Sequence to Sequence – Video to Text Subhashini Venugopalan1 Marcus Rohrbach2,4 Jeff Donahue2 Raymond Mooney1 Trevor Darrell2 Kate Saenko3...1. Introduction Describing visual content with natural language text has recently received increased interest, especially describing images with a

The Experiences of Female High School Students and Interest in STEM: Factors Leading to the Selection of an Engineering or Computer Science Major

ERIC Educational Resources Information Center

Genoways, Sharon K.

2017-01-01

STEM (Science, Technology, Engineering and Math) education creates critical thinkers, increases science literacy, and enables the next generation of innovators, which leads to new products and processes that sustain our economy (Hossain & Robinson, 2012). We have been hearing the warnings for several years, that there simply are not enough…

How Closely Related Are the National Curriculum and the Global Dimension? A Content Analysis of the Global Dimension in Elementary School Textbooks in Taiwan

ERIC Educational Resources Information Center

Chou, Pei-I; Ting, Hsiu-Jung

2016-01-01

Over the past few decades, researchers, educators, and policymakers have become increasingly concerned about preparing future generations for life in the rapidly changing global society; thus, interest in the global dimension of school curricula has been growing. However, as tension often exists between this global dimension and national…

An Exploration of Differences of Leadership Perceptions Related to a Student's Gender within the College of Business at a Small Liberal Arts Institution

ERIC Educational Resources Information Center

Yarrish, Karen K.; Zula, Ken; Davis, Erin

2010-01-01

In preparing the next generation of business professionals, educators need to take seriously the responsibility of empowering students with tools to assist them in their pursuits. One area of interest is leadership. There is an increase in demand for colleges and universities to develop leadership skills in students. Organizations value leadership…

Temperature Insensitive and Radiation Hard Photonics

DTIC Science & Technology

2014-03-19

M. COOK , Lt Col, USAF Deputy Chief, Spacecraft Technology Division Space Vehicles Directorate This report is published in the interest of...Approved for Public Release; distribution is unlimited. ii LIST OF FIGURES Figure 1. OTDM Pulse Multiplexer for Increasing the Output Repetition Rate...QDMLL) for use in extreme environments where ionizing radiation is a substantial threat. Mode-Locked lasers generate a train of optical pulses that have

The Flynn Effect: Technology May Be Part of It, but Is Most Certainly Not All of It

ERIC Educational Resources Information Center

Pietschnig, Jakob

2016-01-01

Clark, Lawlor-Savage, and Goghari (this issue) provide an interesting comment on the explanatory framework of generational IQ test score changes over time in the general population (i.e., the Flynn effect). They argue that IQ test score gains are not due to genuine ability increases in the general population but are rather manifestations of…

DPSSL for direct dicing and drilling of dielectrics

NASA Astrophysics Data System (ADS)

Ashkenasi, David; Schwagmeier, M.

2007-02-01

New strategies in laser micro processing of glasses and other optically transparent materials are being developed with increasing interest and intensity using diode pumped solid state laser (DPSSL) systems generating short or ultra-short pulses in the optical spectra at good beam quality. Utilizing non-linear absorption channels, it can be demonstrated that ns green (532 nm) laser light can scribe, dice, full body cut and drill (flat) borofloat and borosilicate glasses at good quality. Outside of the correct choice in laser parameters, an intelligent laser beam management plays an important role in successful micro processing of glass. This application characterizes a very interesting alternative where standard methods demonstrate severe limitations such as diamond dicing, CO2 laser treatment or water jet cutting, especially for certain type of optical materials and/or geometric conditions. Application near processing examples using different DPSSL systems generating ns pulsed light at 532 nm in TEM 00 at average powers up to 10 W are presented and discussed in respect to potential applications in display technology, micro electronics and optics.

[Thermoconversion of carbonaceous materials to produce synthetic fuels: the biomass case].

PubMed

Dupont, Capucine; Chataing, Thierry; Rougé, Sylvie

2008-01-01

In the present energy context, there is a growing interest for the fuel production from biomass. While the first generation of biofuels has shown its limits, a second generation appears that is based on the valorisation of the unused resources of lignocellulosic biomass. This could significantly increase the biofuels potential in France. Up to 40 % of the total needs of transport fuel could be covered. Among the processes under development, the Biomass to Liquid (BtL) process seems as an interesting route, able to be shortly implemented at an industrial scale. This process consists in producing liquid fuel (such as Diesel Fischer-Trospch) through a synthetic gas obtained by biomass gasification However R&D work is still needed to solve the remaining key issues of the process. These studies are performed in several laboratories in Europe, especially in Germany and in the Nordic countries, and also more recently in France, notably in the Commissariat à l'Energie Atomique.

Suction generation in white-spotted bamboo sharks Chiloscyllium plagiosum.

PubMed

Wilga, Cheryl D; Sanford, Christopher P

2008-10-01

After the divergence of chondrichthyans and teleostomes, the structure of the feeding apparatus also diverged leading to alterations in the suction mechanism. In this study we investigated the mechanism for suction generation during feeding in white-spotted bamboo sharks, Chiloscyllium plagiosum and compared it with that in teleosts. The internal movement of cranial elements and pressure in the buccal, hyoid and pharyngeal cavities that are directly responsible for suction generation was quantified using sonomicrometry and pressure transducers. Backward stepwise multiple linear regressions were used to explore the relationship between expansion and pressure, accounting for 60-96% of the variation in pressure among capture events. The progression of anterior to posterior expansion in the buccal, hyoid and pharyngeal cavities is accompanied by the sequential onset of subambient pressure in these cavities as prey is drawn into the mouth. Gape opening triggers the onset of subambient pressure in the oropharyngeal cavities. Peak gape area coincides with peak subambient buccal pressure. Increased velocity of hyoid area expansion is primarily responsible for generating peak subambient pressure in the buccal and hyoid regions. Pharyngeal expansion appears to function as a sink to receive water influx from the mouth, much like that of compensatory suction in bidirectional aquatic feeders. Interestingly, C. plagiosum generates large suction pressures while paradoxically compressing the buccal cavity laterally, delaying the time to peak pressure. This represents a fundamental difference from the mechanism used to generate suction in teleost fishes. Interestingly, pressure in the three cavities peaks in the posterior to anterior direction. The complex shape changes that the buccal cavity undergoes indicate that, as in teleosts, unsteady flow predominates during suction feeding. Several kinematic variables function together, with great variation over long gape cycles to generate the low subambient pressures used by C. plagiosum to capture prey.

Use of Advanced Solar Cells for Commercial Communication Satellites

NASA Technical Reports Server (NTRS)

Bailey, Sheila G.; Landis, Geoffrey A.

1995-01-01

The current generation of communications satellites are located primarily in geosynchronous Earth orbit (GEO). Over the next decade, however, a new generation of communications satellites will be built and launched, designed to provide a world-wide interconnection of portable telephones. For this mission, the satellites must be positioned in lower polar and near-polar orbits. To provide complete coverage, large numbers of satellites will be required. Because the required number of satellites decreases as the orbital altitude is increased, fewer satellites would be required if the orbit chosen were raised from low to intermediate orbit. However, in intermediate orbits, satellites encounter significant radiation due to trapped electrons and protons. Radiation tolerant solar cells may be necessary to make such satellites feasible. We analyze the amount of radiation encountered in low and intermediate polar orbits at altitudes of interest to next-generation communication satellites, calculate the expected degradation for silicon, GaAs, and InP solar cells, and show that the lifetimes can be significantly increased by use of advanced solar cells.

Use of advanced solar cells for commerical communication satellites

NASA Astrophysics Data System (ADS)

Landis, Geoffrey A.; Bailey, Sheila G.

1995-01-01

The current generation of communications satellites are located primarily in geosynchronous Earth orbit (GEO). Over the next decade, however, a new generation of communications satellites will be built and launched, designed to provide a world-wide interconnection of portable telephones. For this mission, the satellites must be positioned in lower polar- and near-polar orbits. To provide complete coverage, large numbers of satellites will be required. Because of the required number of satellites decreases as the orbital altitude is increased, fewer satellites would be required if the orbit chosen were raised from Low to intermediate orbit. However, in intermediate orbits, satellites encounter significant radiation due to trapped electrons and protons. Radiation tolerant solar cells may be necessary to make such satellites feasible. We analyze the amount of radiation encountered in low and intermediate polar orbits at altitudes of interest to next-generation communication satellites, calculate the expected degradation for silicon, GaAs, and InP solar cells, and show that the lifetimes can be significantly increased by use of advanced solar cells.

Use of advanced solar cells for commercial communication satellites

NASA Astrophysics Data System (ADS)

Bailey, Sheila G.; Landis, Geoffrey A.

1995-03-01

The current generation of communications satellites are located primarily in geosynchronous Earth orbit (GEO). Over the next decade, however, a new generation of communications satellites will be built and launched, designed to provide a world-wide interconnection of portable telephones. For this mission, the satellites must be positioned in lower polar and near-polar orbits. To provide complete coverage, large numbers of satellites will be required. Because the required number of satellites decreases as the orbital altitude is increased, fewer satellites would be required if the orbit chosen were raised from low to intermediate orbit. However, in intermediate orbits, satellites encounter significant radiation due to trapped electrons and protons. Radiation tolerant solar cells may be necessary to make such satellites feasible. We analyze the amount of radiation encountered in low and intermediate polar orbits at altitudes of interest to next-generation communication satellites, calculate the expected degradation for silicon, GaAs, and InP solar cells, and show that the lifetimes can be significantly increased by use of advanced solar cells.

Testing the social cognitive career theory in Thai nurses' interest to become nurse educators: A structural equation modeling analysis.

PubMed

Thungjaroenkul, Petsunee; G Cummings, Greta; Tate, Kaitlyn

2016-09-01

A shortage of nurse educators generates a systemic problem in nursing education. A model to develop interventions directed at enhancing graduate nursing student interest in assuming a future faculty role is needed. This study used a social cognitive career theory perspective to examine the effects of past performance in teaching and supervision, social influence, observing others teaching, perceived task demands for nurse educators, self-efficacy, and outcome expectations on Thai graduate nursing students' (n=236) interest to become a nurse educator. Results of structural equation modeling analyses revealed that social influence and past performance in teaching and supervision had significant effects on interest to become a nurse educator when mediated by self-efficacy and outcome expectations. Observing others teaching and perceived task demands for nurse educators did not significantly predict interest in faculty roles. These findings provide new knowledge about factors and their influence on the development of interest to assume faculty roles. Implications for nursing education include the design of feasible graduate curricula that enhance students' abilities in faculty role and increases valuation of teaching careers. Copyright © 2016 Elsevier Ltd. All rights reserved.

Regionalökonomische Bedeutung kleiner Wallfahrtsorte. Lokale Wertschöpfung am Beispiel Biberbach (Bayerisch-Schwaben)

NASA Astrophysics Data System (ADS)

Hilpert, Markus; Mahne-Bieder, Johannes; Stifter, Vanessa

2016-09-01

Today pilgrimage is experiencing an increasing interest, although motives are notable changing. Sites along pilgrim routes normally profit in an economically way. But until today regional economic effects of even very small pilgrimage sites are underexplored. Therefore economic impulses of the pilgrimage site in Biberbach (Bavaria) were identified using interviews and calculations. According to that the 10,000 visitors per year generate nearly 30,000 € gross turnover and 0.5 jobs. So even small pilgrimage sites can obviously produce a notable increase of local EVA.

Robust and Low-Cost Flame-Treated Wood for High-Performance Solar Steam Generation.

PubMed

Xue, Guobin; Liu, Kang; Chen, Qian; Yang, Peihua; Li, Jia; Ding, Tianpeng; Duan, Jiangjiang; Qi, Bei; Zhou, Jun

2017-05-03

Solar-enabled steam generation has attracted increasing interest in recent years because of its potential applications in power generation, desalination, and wastewater treatment, among others. Recent studies have reported many strategies for promoting the efficiency of steam generation by employing absorbers based on carbon materials or plasmonic metal nanoparticles with well-defined pores. In this work, we report that natural wood can be utilized as an ideal solar absorber after a simple flame treatment. With ultrahigh solar absorbance (∼99%), low thermal conductivity (0.33 W m -1 K -1 ), and good hydrophilicity, the flame-treated wood can localize the solar heating at the evaporation surface and enable a solar-thermal efficiency of ∼72% under a solar intensity of 1 kW m -2 , and it thus represents a renewable, scalable, low-cost, and robust material for solar steam applications.

Broadband multi-wavelength Brillouin lasers with an operating wavelength range of 1500–1600 nm generated by four-wave mixing in a dual wavelength Brillouin fiber laser cavity

NASA Astrophysics Data System (ADS)

Li, Q.; Jia, Z. X.; Weng, H. Z.; Li, Z. R.; Yang, Y. D.; Xiao, J. L.; Chen, S. W.; Huang, Y. Z.; Qin, W. P.; Qin, G. S.

2018-05-01

We demonstrate broadband multi-wavelength Brillouin lasers with an operating wavelength range of 1500–1600 nm and a frequency separation of ~9.28 GHz generated by four-wave mixing in a dual wavelength Brillouin fiber laser cavity. By using one continuous-wave laser as the pump source, multi-wavelength Brillouin lasers with an operating wavelength range of 1554–1574 nm were generated via cascaded Brillouin scattering and four-wave mixing. Interestingly, when pumped by two continuous-wave lasers with an appropriate frequency separation, the operating wavelength range of the multi-wavelength Brillouin lasers was increased to 1500–1600 nm due to cavity-enhanced cascaded four-wave mixing among the frequency components generated by two pump lasers in the dual wavelength Brillouin laser cavity.

Generative Representations for Computer-Automated Design Systems

NASA Technical Reports Server (NTRS)

Hornby, Gregory S.

2004-01-01

With the increasing computational power of Computers, software design systems are progressing from being tools for architects and designers to express their ideas to tools capable of creating designs under human guidance. One of the main limitations for these computer-automated design programs is the representation with which they encode designs. If the representation cannot encode a certain design, then the design program cannot produce it. Similarly, a poor representation makes some types of designs extremely unlikely to be created. Here we define generative representations as those representations which can create and reuse organizational units within a design and argue that reuse is necessary for design systems to scale to more complex and interesting designs. To support our argument we describe GENRE, an evolutionary design program that uses both a generative and a non-generative representation, and compare the results of evolving designs with both types of representations.

Optimization principles and the figure of merit for triboelectric generators.

PubMed

Peng, Jun; Kang, Stephen Dongmin; Snyder, G Jeffrey

2017-12-01

Energy harvesting with triboelectric nanogenerators is a burgeoning field, with a growing portfolio of creative application schemes attracting much interest. Although power generation capabilities and its optimization are one of the most important subjects, a satisfactory elemental model that illustrates the basic principles and sets the optimization guideline remains elusive. We use a simple model to clarify how the energy generation mechanism is electrostatic induction but with a time-varying character that makes the optimal matching for power generation more restrictive. By combining multiple parameters into dimensionless variables, we pinpoint the optimum condition with only two independent parameters, leading to predictions of the maximum limit of power density, which allows us to derive the triboelectric material and device figure of merit. We reveal the importance of optimizing device capacitance, not only load resistance, and minimizing the impact of parasitic capacitance. Optimized capacitances can lead to an overall increase in power density of more than 10 times.

Research and Development Supporting a Next Generation Germanium Double Beta Decay Experiment

NASA Astrophysics Data System (ADS)

Rielage, Keith; Elliott, Steve; Chu, Pinghan; Goett, Johnny; Massarczyk, Ralph; Xu, Wenqin

2015-10-01

To improve the search for neutrinoless double beta decay, the next-generation experiments will increase in source mass and continue to reduce backgrounds in the region of interest. A promising technology for the next generation experiment is large arrays of Germanium p-type point contact detectors enriched in 76-Ge. The experience, expertise and lessons learned from the MAJORANA DEMONSTRATOR and GERDA experiments naturally lead to a number of research and development activities that will be useful in guiding a future experiment utilizing Germanium. We will discuss some R&D activities including a hybrid cryostat design, background reduction in cabling, connectors and electronics, and modifications to reduce assembly time. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.

Mean-variance portfolio analysis data for optimizing community-based photovoltaic investment.

PubMed

Shakouri, Mahmoud; Lee, Hyun Woo

2016-03-01

The amount of electricity generated by Photovoltaic (PV) systems is affected by factors such as shading, building orientation and roof slope. To increase electricity generation and reduce volatility in generation of PV systems, a portfolio of PV systems can be made which takes advantages of the potential synergy among neighboring buildings. This paper contains data supporting the research article entitled: PACPIM: new decision-support model of optimized portfolio analysis for community-based photovoltaic investment [1]. We present a set of data relating to physical properties of 24 houses in Oregon, USA, along with simulated hourly electricity data for the installed PV systems. The developed Matlab code to construct optimized portfolios is also provided in . The application of these files can be generalized to variety of communities interested in investing on PV systems.

Microwave Memristive-like Nonlinearity in a Dielectric Metamaterial

PubMed Central

Wu, Hongya; Zhou, Ji; Lan, Chuwen; Guo, Yunsheng; Bi, Ke

2014-01-01

Memristor exhibit interesting and valuable circuit properties and have thus become the subject of increasing scientific interest. Scientists wonder if they can conceive a microwave memristor that behaves as a memristor operating with electromagnetic fields. Here, we report a microwave memristive-like nonlinear phenomenon at room temperature in dielectric metamaterials consisting of CaTiO3-ZrO2 ceramic dielectric cubes. Hysteretic transmission-incident field power loops (similar to the hysteretic I-V loop of memristor which is the fingerprint of memristor) with various characteristics were systematically observed in the metamaterials, which exhibited designable microwave memristive-like behavior. The effect is attributed to the decreasing permittivity of the dielectric cubes with the increasing temperature generated by the interaction between the electromagnetic waves and the dielectric cubes. This work demonstrates the feasibility of fabrication transient photonic memristor at microwave frequencies with metamaterials. PMID:24975455

Application of a weak magnetic field to improve microbial fuel cell performance.

PubMed

Tong, Zhong-Hua; Yu, Han-Qing; Li, Wen-Wei; Wang, Yun-Kun; Sun, Min; Liu, Xian-Wei; Sheng, Guo-Ping

2015-12-01

Microbial fuel cells (MFCs) have emerged as a promising technology for wastewater treatment with concomitant energy production but the performance is usually limited by low microbial activities. This has spurred intensive research interest for microbial enhancement. This study demonstrated an interesting stimulation effect of a static magnetic field (MF) on sludge-inoculated MFCs and explored into the mechanisms. The implementation of a 100-mT MF accelerated the reactor startup and led to increased electricity generation. Under the MF exposure, the activation loss of the MFC was decreased, but there was no increased secretion of redox mediators. Thus, the MF effect was mainly due to enhanced bioelectrochemical activities of anodic microorganisms, which are likely attributed to the oxidative stress and magnetohydrodynamic effects under an MF exposure. This work implies that weak MF may be applied as a simple and effective approach to stimulate microbial activities for various bioelectrochemical energy production and decontamination applications.

Sea Spray Generation at a Rocky Shoreline

DTIC Science & Technology

2015-07-01

exploration, and 47 production platforms—will face increased hazards from freezing sea spray. 48 Based on sea spray observations made with a cloud...produce higher waves (e.g., Perrie et al. 2012; Asplin et 65 al. 2012). Such evolving conditions will present new hazards for artificial structures like...wind and waves themselves will create hazards for 68 these structures, my interest here is the attendant sea spray produced. 69 Jones and Andreas

Intensive Home Hemodialysis: An Eye at the Past Looking for the Hemodialysis of the Future.

PubMed

Naso, Agostino; Scaparrotta, Giuseppe; Naso, Elena; Calò, Lorenzo A

2015-09-01

Multiple observational studies along with a limited number of randomized clinical trials suggest that intensive hemodialysis (IHD) not only improves outcomes for uremic patients undergoing chronic dialysis but does so with a more favorable cost/benefit ratio compared with conventional hemodialysis. As a result of this, there has been a rapid increase in the interest in home hemodialysis (HHD) as HHD represents the easiest means of implementing IHD. While HHD has generated increased interest given its association with better outcomes/reduced hospitalizations, there are very few randomized controlled trials comparing HHD with other hemodialysis methods. Reported HHD-associated increased survival benefits compared with in-center hemodialysis are from uncontrolled studies, which raise patient selection bias as underlying the differences found. Thus, while HHD draws increasing attention, studies that pay careful attention to the psychosocial, demographic, and clinical factors associated with patients selected to undergo HHD will be needed to ultimately demonstrate its benefits, clarify the clinical applications, and determine the limits of IHD use in dialysis patients. Copyright © 2015 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

[Assessment of gestures and their psychiatric relevance].

PubMed

Bulucz, Judit; Simon, Lajos

2008-01-01

Analyzing and investigating non-verbal behavior and gestures has been receiving much attention since the last century. Thanks to the pioneer work of Ekman and Friesen we have a number of descriptive-analytic, categorizing and semantic content related scales and scoring systems. Generation of gestures, the integrative system with speech and the inter-cultural differences are in the focus of interest. Furthermore, analysis of the gestural changes caused by lesions of distinct neurological areas point toward to formation of new diagnostic approaches. The more widespread application of computerized methods resulted in an increasing number of experiments which study gesture generation, reproduction in mechanical and virtual reality. Increasing efforts are directed towards the understanding of human and computerized recognition of human gestures. In this review we describe the results emphasizing the relations of those results with psychiatric and neuropsychiatric disorders, specifically schizophrenia and affective spectrum.

Nanostructural hierarchy increases the strength of aluminium alloys.

PubMed

Liddicoat, Peter V; Liao, Xiao-Zhou; Zhao, Yonghao; Zhu, Yuntian; Murashkin, Maxim Y; Lavernia, Enrique J; Valiev, Ruslan Z; Ringer, Simon P

2010-09-07

Increasing the strength of metallic alloys while maintaining formability is an interesting challenge for enabling new generations of lightweight structures and technologies. In this paper, we engineer aluminium alloys to contain a hierarchy of nanostructures and possess mechanical properties that expand known performance boundaries-an aerospace-grade 7075 alloy exhibits a yield strength and uniform elongation approaching 1 GPa and 5%, respectively. The nanostructural architecture was observed using novel high-resolution microscopy techniques and comprises a solid solution, free of precipitation, featuring (i) a high density of dislocations, (ii) subnanometre intragranular solute clusters, (iii) two geometries of nanometre-scale intergranular solute structures and (iv) grain sizes tens of nanometres in diameter. Our results demonstrate that this novel architecture offers a design pathway towards a new generation of super-strong materials with new regimes of property-performance space.

Considerations on data acquisition in laser ablation-inductively coupled plasma-mass spectrometry with low-dispersion interfaces

NASA Astrophysics Data System (ADS)

Van Malderen, Stijn J. M.; van Elteren, Johannes T.; Šelih, Vid S.; Vanhaecke, Frank

2018-02-01

This work describes the aliasing effects induced by undersampling the high-frequency signal patterns generated by a laser ablation-inductively coupled plasma-mass spectrometer equipped with a low-dispersion ablation cell and sequential mass analyzer. By characterizing the width of the signal peak generated from a single shot on the sample, critical experimental parameters, such as the laser repetition rate and detector cycle timings for the individual nuclides can be matched so as to avoid these imaging artifacts (spectral skew) induced by an insufficient sampling rate. By increasing the laser repetition rate by a factor 2-3, masses at the end of the mass scan can be sampled at higher sensitivity. Furthermore, the dwell times can be redistributed over the nuclides of interest based on the signal-to-noise ratio to increase the image contrast.

A package for 3-D unstructured grid generation, finite-element flow solution and flow field visualization

NASA Technical Reports Server (NTRS)

Parikh, Paresh; Pirzadeh, Shahyar; Loehner, Rainald

1990-01-01

A set of computer programs for 3-D unstructured grid generation, fluid flow calculations, and flow field visualization was developed. The grid generation program, called VGRID3D, generates grids over complex configurations using the advancing front method. In this method, the point and element generation is accomplished simultaneously, VPLOT3D is an interactive, menudriven pre- and post-processor graphics program for interpolation and display of unstructured grid data. The flow solver, VFLOW3D, is an Euler equation solver based on an explicit, two-step, Taylor-Galerkin algorithm which uses the Flux Corrected Transport (FCT) concept for a wriggle-free solution. Using these programs, increasingly complex 3-D configurations of interest to aerospace community were gridded including a complete Space Transportation System comprised of the space-shuttle orbitor, the solid-rocket boosters, and the external tank. Flow solutions were obtained on various configurations in subsonic, transonic, and supersonic flow regimes.

Sequence Data for Clostridium autoethanogenum using Three Generations of Sequencing Technologies

DOE PAGES

Utturkar, Sagar M.; Klingeman, Dawn Marie; Bruno-Barcena, José M.; ...

2015-04-14

During the past decade, DNA sequencing output has been mostly dominated by the second generation sequencing platforms which are characterized by low cost, high throughput and shorter read lengths for example, Illumina. The emergence and development of so called third generation sequencing platforms such as PacBio has permitted exceptionally long reads (over 20 kb) to be generated. Due to read length increases, algorithm improvements and hybrid assembly approaches, the concept of one chromosome, one contig and automated finishing of microbial genomes is now a realistic and achievable task for many microbial laboratories. In this paper, we describe high quality sequencemore » datasets which span three generations of sequencing technologies, containing six types of data from four NGS platforms and originating from a single microorganism, Clostridium autoethanogenum. The dataset reported here will be useful for the scientific community to evaluate upcoming NGS platforms, enabling comparison of existing and novel bioinformatics approaches and will encourage interest in the development of innovative experimental and computational methods for NGS data.« less

Relativistic frequency upshift to the extreme ultraviolet regime using self-induced oscillatory flying mirrors

PubMed Central

Kim, I Jong; Pae, Ki Hong; Kim, Chul Min; Kim, Hyung Taek; Yun, Hyeok; Yun, Sang Jae; Sung, Jae Hee; Lee, Seong Ku; Yoon, Jin Woo; Yu, Tae Jun; Jeong, Tae Moon; Nam, Chang Hee; Lee, Jongmin

2012-01-01

Coherent short-wavelength radiation from laser–plasma interactions is of increasing interest in disciplines including ultrafast biomolecular imaging and attosecond physics. Using solid targets instead of atomic gases could enable the generation of coherent extreme ultraviolet radiation with higher energy and more energetic photons. Here we present the generation of extreme ultraviolet radiation through coherent high-harmonic generation from self-induced oscillatory flying mirrors—a new-generation mechanism established in a long underdense plasma on a solid target. Using a 30-fs, 100-TW Ti:sapphire laser, we obtain wavelengths as short as 4.9 nm for an optimized level of amplified spontaneous emission. Particle-in-cell simulations show that oscillatory flying electron nanosheets form in a long underdense plasma, and suggest that the high-harmonic generation is caused by reflection of the laser pulse from electron nanosheets. We expect this extreme ultraviolet radiation to be valuable in realizing a compact X-ray instrument for research in biomolecular imaging and attosecond physics. PMID:23187631

Multiple Interests of Users in Collaborative Tagging Systems

NASA Astrophysics Data System (ADS)

Au Yeung, Ching-Man; Gibbins, Nicholas; Shadbolt, Nigel

Performance of recommender systems depends on whether the user profiles contain accurate information about the interests of the users, and this in turn relies on whether enough information about their interests can be collected. Collaborative tagging systems allow users to use their own words to describe their favourite resources, resulting in some user-generated categorisation schemes commonly known as folksonomies. Folksonomies thus contain rich information about the interests of the users, which can be used to support various recommender systems. Our analysis of the folksonomy in Delicious reveals that the interests of a single user can be very diverse. Traditional methods for representing interests of users are usually not able to reflect such diversity. We propose a method to construct user profiles of multiple interests from folksonomies based on a network clustering technique. Our evaluation shows that the proposed method is able to generate user profiles which reflect the diversity of user interests and can be used as a basis of providing more focused recommendation to the users.

Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis.

PubMed

Anway, Matthew D; Rekow, Stephen S; Skinner, Michael K

2008-10-01

Exposure of gestating female rats to the anti-androgenic endocrine disruptor vinclozolin has been shown to induce transgenerational adult onset disease phenotypes. The current study, was designed to compare the actions of vinclozolin to the known anti-androgenic compound flutamide. The gestating female rats were exposed to intraperitoneal injections during embryonic day 8-14 (E8-E14) to 100mg/kg/day vinclozolin or flutamide at either 5mg or 20mg/kg/day. As previously observed, vinclozolin induced a transgenerational testis phenotype of increased spermatogenic cell apoptosis and decreased epididymal sperm number. In contrast, the flutamide exposures resulted in a testis phenotype of increased spermatogenic cell apoptosis and decreased epididymal sperm numbers in the F1 generation only, and not the F2 and F3 generation adult males. Interestingly, some of the low dose (5mg/kg) flutamide F2 generation offspring developed spinal agenesis and supernummery development (polymelia) of limbs. Although the actions of vinclozolin and flutamide appear similar in the F1 generation males, the transgenerational effects of vinclozolin do not appear to be acting through the same anti-androgenic mechanism as flutamide.

Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis

PubMed Central

Anway, Matthew D.; Rekow, Stephen S.; Skinner, Michael K.

2017-01-01

Exposure of gestating female rats to the anti-androgenic endocrine disruptor vinclozolin has been shown to induce transgenerational adult onset disease phenotypes. The current study, was designed to compare the actions of vinclozolin to the known anti-androgenic compound flutamide. The gestating female rats were exposed to intraperitoneal injections during embryonic day 8–14 (E8–E14) to 100 mg/kg/day vinclozolin or flutamide at either 5mg or 20 mg/kg/day. As previously observed, vinclozolin induced a transgenerational testis phenotype of increased spermatogenic cell apoptosis and decreased epididymal sperm number. In contrast, the flutamide exposures resulted in a testis phenotype of increased spermatogenic cell apoptosis and decreasedepididymal spermnumbers in the F1 generation only, and not the F2 and F3 generation adult males. Interestingly, some of the lowdose (5 mg/kg) flutamide F2 generation offspring developed spinal agenesis and supernummery development (polymelia) of limbs. Although the actions of vinclozolin and flutamide appear similar in the F1 generation males, the transgenerational effects of vinclozolin do not appear to be acting through the same anti-androgenic mechanism as flutamide. PMID:18762243

Design and process integration of organic Rankine cycle utilizing biomass for power generation

NASA Astrophysics Data System (ADS)

Ependi, S.; Nur, T. B.

2018-02-01

Indonesia has high potential biomass energy sources from palm oil mill industry activities. The growing interest on Organic Rankine Cycle (ORC) application to produce electricity by utilizing biomass energy sources are increasingly due to its successfully used for generating electricity from rejected waste heat to the environment in industrial processes. In this study, the potential of the palm oil empty fruit bunch, and wood chip have been used as fuel for biomass to generate electricity based ORC with combustion processes. The heat from combustion burner was transfer by thermal oil heater to evaporate ORC working fluid in the evaporator unit. The Syltherm-XLT thermal oil was used as the heat carrier from combustion burner, while R245fa was used as the working fluid for ORC unit. Appropriate designs integration from biomass combustion unit to ORC unit have been analyzed and proposed to generate expander shaft-work. Moreover, the effect of recuperator on the total system efficiency has also been investigated. It was observed that the fuel consumption was increased when the ORC unit equipped recuperator operated until certain pressure and decreased when operated at high pressure.

On the scaling and dynamics of periodically generated vortex rings

NASA Astrophysics Data System (ADS)

Asadi, Hossein; Asgharzadeh, Hafez; Borazjani, Iman; Scientific Computing; Biofluids Team

2017-11-01

Periodically generated vortex rings are observed in nature, e.g., left ventricle or jellyfish, but their scaling and dynamics is not completely well understood. We are interested in identifying the main parameters governing the propagation and dynamics of periodically generated vortex rings. Therefore, vortex rings, generated periodically through a circular cylinder into a tank, is numerically investigated for a range of Reynolds numbers (Re), non-dimensional periods (T), and stroke ratios (stroke time to period) for a simple square wave. Based on the results, by using the averaged inflow velocity in definition of Reynolds number and non-dimensional period, vortex ring velocity becomes approximately independent of the stroke ratio. The results also show that reducing Reynolds number or increasing non-dimensional period increases the translational velocity of vortex ring. Based on our test cases, an empirical relation is proposed to predict the location of vortex cores propagating into domain which shows good agreement with other experimental data. The vortex instabilities and interactions are also visualized and discussed. This work was supported by AHA Grant 13SDG17220022, NIH Grant R03EB014860, and the Center of Computational Research (CCR) of University at Buffalo.

Optimising the selection of food items for FFQs using Mixed Integer Linear Programming.

PubMed

Gerdessen, Johanna C; Souverein, Olga W; van 't Veer, Pieter; de Vries, Jeanne Hm

2015-01-01

To support the selection of food items for FFQs in such a way that the amount of information on all relevant nutrients is maximised while the food list is as short as possible. Selection of the most informative food items to be included in FFQs was modelled as a Mixed Integer Linear Programming (MILP) model. The methodology was demonstrated for an FFQ with interest in energy, total protein, total fat, saturated fat, monounsaturated fat, polyunsaturated fat, total carbohydrates, mono- and disaccharides, dietary fibre and potassium. The food lists generated by the MILP model have good performance in terms of length, coverage and R 2 (explained variance) of all nutrients. MILP-generated food lists were 32-40 % shorter than a benchmark food list, whereas their quality in terms of R 2 was similar to that of the benchmark. The results suggest that the MILP model makes the selection process faster, more standardised and transparent, and is especially helpful in coping with multiple nutrients. The complexity of the method does not increase with increasing number of nutrients. The generated food lists appear either shorter or provide more information than a food list generated without the MILP model.

An Anti-Parkinson’s Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity

PubMed Central

Li, Xiaohang; Wang, Xin; Zhou, Yue; Yang, Wenjuan; Chen, Ming; Zhao, Jian; Pei, Gang

2016-01-01

γ-secretase mediates the intramembranous proteolysis of amyloid precursor protein (APP) and determines the generation of Aβ which is associated with Alzheimer’s disease (AD). Here we identified that an anti-Parkinson’s disease drug, Istradefylline, could enhance Aβ generation in various cell lines and primary neuronal cells of APP/PS1 mouse. Moreover, the increased generation of Aβ42 was detected in the cortex of APP/PS1 mouse after chronic treatment with Istradefylline. Istradefylline promoted the activity of γ-secretase which could lead to increased Aβ production. These effects of Istradefylline were reduced by the knockdown of A2AR but independent of A2AR-mediated G protein- or β-arrestin-dependent signal pathway. We further observed that A2AR colocalized with γ-secretase in endosomes and physically interacted with the catalytic subunit presenilin-1 (PS1). Interestingly, Istradefylline attenuated the interaction in time- and dosage-dependent manners. Moreover the knockdown of A2AR which in theory would release PS1 potentiated both Aβ generation and γ-secretase activity. Thus, our study implies that the association of A2AR could modulate γ-secretase activity. Istradefylline enhance Aβ generation and γ-secretase activity possibly via modulating the interaction between A2AR and γ-secretase, which may bring some undesired effects in the central nervous system (CNS). PMID:27835671

The role of local populations within a landscape context: Defining and classifying sources and sinks

USGS Publications Warehouse

Runge, J.P.; Runge, M.C.; Nichols, J.D.

2006-01-01

The interaction of local populations has been the focus of an increasing number of studies in the past 30 years. The study of source-sink dynamics has especially generated much interest. Many of the criteria used to distinguish sources and sinks incorporate the process of apparent survival (i.e., the combined probability of true survival and site fidelity) but not emigration. These criteria implicitly treat emigration as mortality, thus biasing the classification of sources and sinks in a manner that could lead to flawed habitat management. Some of the same criteria require rather restrictive assumptions about population equilibrium that, when violated, can also generate misleading inference. Here, we expand on a criterion (denoted ?contribution? or Cr) that incorporates successful emigration in differentiating sources and sinks and that makes no restrictive assumptions about dispersal or equilibrium processes in populations of interest. The metric Cr is rooted in the theory of matrix population models, yet it also contains clearly specified parameters that have been estimated in previous empirical research. We suggest that estimates of emigration are important for delineating sources and sinks and, more generally, for evaluating how local populations interact to generate overall system dynamics. This suggestion has direct implications for issues such as species conservation and habitat management.

Hydrogen generation via photoelectrochemical water splitting using chemically exfoliated MoS{sub 2} layers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Joshi, R. K., E-mail: r.joshi@unsw.edu.au, E-mail: alwarappan@cecri.res.in; Sahajwalla, V.; Shukla, S.

2016-01-15

Study on hydrogen generation has been of huge interest due to increasing demand for new energy sources. Photoelectrochemical reaction by catalysts was proposed as a promising technique for hydrogen generation. Herein, we report the hydrogen generation via photoelectrochecmial reaction using films of exfoliated 2-dimensional (2D) MoS{sub 2}, which acts as an efficient photocatalyst. The film of chemically exfoliated MoS{sub 2} layers was employed for water splitting, leading to hydrogen generation. The amount of hydrogen was qualitatively monitored by observing overpressure of a water container. The high photo-current generated by MoS{sub 2} film resulted in hydrogen evolution. Our work shows thatmore » 2D MoS{sub 2} is one of the promising candidates as a photocatalyst for light-induced hydrogen generation. High photoelectrocatalytic efficiency of the 2D MoS{sub 2} shows a new way toward hydrogen generation, which is one of the renewable energy sources. The efficient photoelectrocatalytic property of the 2D MoS{sub 2} is possibly due to availability of catalytically active edge sites together with minimal stacking that favors the electron transfer.« less

Participant action research with bedside nurses to identify NANDA-International, Nursing Interventions Classification, and Nursing Outcomes Classification categories for hospitalized persons with diabetes.

PubMed

Minthorn, Crista; Lunney, Margaret

2012-05-01

Experienced bedside nurses identified 14 nursing diagnoses, 78 interventions, and 76 health outcomes for hospitalized persons with diabetes. Using these terms, the nursing department revised the standards of care and the electronic health record. Nurses' engagement in generating knowledge translated to increased interest in research. This methodology is recommended for other agencies. Copyright © 2012 Elsevier Inc. All rights reserved.

The creative brain in the figural domain: Distinct patterns of EEG alpha power during idea generation and idea elaboration.

PubMed

Rominger, Christian; Papousek, Ilona; Perchtold, Corinna M; Weber, Bernhard; Weiss, Elisabeth M; Fink, Andreas

2018-02-13

This study investigated EEG activity in the upper alpha band during the well-known Picture Completion Task of the Torrance Test of Creative Thinking (TTCT), a widely used creative ideation task in the figural domain. The application of a sophisticated computerized version of the TTCT facilitating the online assessment and digitalizing of participant's drawings allowed to separate two central stages of the creative ideation process (i.e., idea generation and idea elaboration). During idea generation, the participants' task was to generate an initial draft of an original and creative completion of the presented abstract lines and figures of the TTCT. During idea elaboration, the participants were required to mentally improve the originality of the initially generated idea/draft. Creative ideation in this figural task was generally associated with comparatively strong desynchronization of upper alpha power over parietal and occipital sites, indicating high visual/figural processing demands. Interestingly, the stage of idea elaboration was accompanied by a relative increase of upper alpha power at parietal and occipital sites compared to the stage of idea generation, indicating heightened top-down processing demands. Furthermore, task performance was associated with relative increases of upper alpha power at frontal sites and relative decreases at centro-temporal sites from the stage of idea generation to idea elaboration. This association suggests the importance of increased inhibitory control over stimulus-based bottom-up information and motor imagery in order to achieve more creative outputs. Taken together these findings add to the relevant literature in that they a) extend research on the relationship between EEG alpha activity and creativity to the figural domain, and b) support a multistage view of creative ideation, involving cognitive control and mental imagery as important components of creativity. Copyright © 2018 Elsevier Ltd. All rights reserved.

Calcification and photosynthesis of the coral acropora cervicornis under calcium limited conditions

NASA Technical Reports Server (NTRS)

Rathfon, Megan; Brewer, Debbie

1997-01-01

Differing hypothesis about the function of calcification are based on an interesting dilemma. Is the purpose of calcification mainly a structural and protective one or does calcification serve other functions? Does photosynthesis increase carbonate ion activity and cause calcification or does calcification increase CO2 levels and stimulate photsynthesis? It is proposed that calcification in corals is not dependent upon photosynthesis but upon calcium levels in the water. Under normal ocean conditions, corals convert a certain percentage of energy to photosynthesis and respiration and another percentage to calcification. As corals become nutrient stressed, particularly calcium limited, the ratio of photosynthesis to calcification shifts towards calcification in order to generate protons. The protons generated during calcification may stimulate photosynthesis and aid in the uptake of nutrients and biocarbonates. The results of the calcification experiment show a trend towards increased calcification and decreased photosynthesis when the coral Acropora cervicornis is calcium limited, but the data are inconclusive and further research is needed.

Caloric Restriction-Induced Extension of Chronological Lifespan Requires Intact Respiration in Budding Yeast.

PubMed

Kwon, Young-Yon; Lee, Sung-Keun; Lee, Cheol-Koo

2017-04-01

Caloric restriction (CR) has been shown to extend lifespan and prevent cellular senescence in various species ranging from yeast to humans. Many effects of CR may contribute to extend lifespan. Specifically, CR prevents oxidative damage from reactive oxygen species (ROS) by enhancing mitochondrial function. In this study, we characterized 33 single electron transport chain (ETC) gene-deletion strains to identify CR-induced chronological lifespan (CLS) extension mechanisms. Interestingly, defects in 17 of these 33 ETC gene-deleted strains showed loss of both respiratory function and CR-induced CLS extension. On the contrary, the other 16 respiration-capable mutants showed increased CLS upon CR along with increased mitochondrial membrane potential (MMP) and intracellular adenosine triphosphate (ATP) levels, with decreased mitochondrial superoxide generation. We measured the same parameters in the 17 non-respiratory mutants upon CR. CR simultaneously increased MMP and mitochondrial superoxide generation without altering intracellular ATP levels. In conclusion, respiration is essential for CLS extension by CR and is important for balancing MMP, ROS, and ATP levels.

Factors that facilitate or inhibit interest of domestic students in the engineering PhD: A mixed methods study

NASA Astrophysics Data System (ADS)

Howell Smith, Michelle C.

Given the increasing complexity of technology in our society, the United States has a growing demand for a more highly educated technical workforce. Unfortunately, the proportion of United States citizens earning a PhD in engineering has been declining and there is concern about meeting the economic, national security and quality of life needs of our country. This mixed methods sequential exploratory instrument design study identified factors that facilitate or inhibit interest in engineering PhD programs among domestic engineering undergraduate students in the United States. This study developed a testable theory for how domestic students become interested in engineering PhD programs and a measure of that process, the Exploring Engineering Interest Inventory (EEII). The study was conducted in four phases. The first phase of the study was a qualitative grounded theory exploration of interest in the engineering PhD. Qualitative data were collected from domestic engineering students, engineering faculty and industry professional who had earned a PhD in engineering. The second phase, instrument development, developed the Exploring Engineering Interest Inventory (EEII), a measurement instrument designed with good psychometric properties to test a series of preliminary hypotheses related to the theory generated in the qualitative phase. In the third phase of the study, the EEII was used to collect data from a larger sample of junior and senior engineering majors. The fourth phase integrated the findings from the qualitative and quantitative phases. Four factors were identified as being significant influences of interest in the engineering PhD: Personal characteristics, educational environment, misperceptions of the economic and personal costs, and misperceptions of engineering work. Recommendations include increasing faculty encouragement of students to pursue an engineering PhD and programming to correct the misperceptions of the costs of the engineering PhD and the nature of the work that PhD engineers do. The tested model provides engineering educators with information to help them prioritize their efforts to increase interest in the engineering PhD among domestic students.

Mean-variance portfolio analysis data for optimizing community-based photovoltaic investment

PubMed Central

Shakouri, Mahmoud; Lee, Hyun Woo

2016-01-01

The amount of electricity generated by Photovoltaic (PV) systems is affected by factors such as shading, building orientation and roof slope. To increase electricity generation and reduce volatility in generation of PV systems, a portfolio of PV systems can be made which takes advantages of the potential synergy among neighboring buildings. This paper contains data supporting the research article entitled: PACPIM: new decision-support model of optimized portfolio analysis for community-based photovoltaic investment [1]. We present a set of data relating to physical properties of 24 houses in Oregon, USA, along with simulated hourly electricity data for the installed PV systems. The developed Matlab code to construct optimized portfolios is also provided in Supplementary materials. The application of these files can be generalized to variety of communities interested in investing on PV systems. PMID:26937458

[Promising Future in General Internal Medicine for the Next Generation of Physicians].

PubMed

Allenbach, Victoria Perpinias; Rozsnyai, Zsofia; Streit, Sven

2018-06-01

Promising Future in General Internal Medicine for the Next Generation of Physicians Abstract. We are facing a lack of specialists in general internal medicine in general practitioners' practices as well as in hospitals, while at the same time the population ages and usually displays several chronic diseases (multimorbidity). Thanks to more university places, an improved job description for general internal medicine and new further education offers (curricula), interest in general internal medicine increased again, as surveys of students indicate. The young generation of family doctors and generalists in hospitals wishes flexible working conditions in order to reconcile work, family and spare time in the best possible way. Working atmosphere and colleagues have a high priority. These wishes must now be incorporated into attractive further training with flexible curricula and mentoring offers so that young talents can successfully be promoted.

Automated Transformation of CDISC ODM to OpenClinica.

PubMed

Gessner, Sophia; Storck, Michael; Hegselmann, Stefan; Dugas, Martin; Soto-Rey, Iñaki

2017-01-01

Due to the increasing use of electronic data capture systems for clinical research, the interest in saving resources by automatically generating and reusing case report forms in clinical studies is growing. OpenClinica, an open-source electronic data capture system enables the reuse of metadata in its own Excel import template, hampering the reuse of metadata defined in other standard formats. One of these standard formats is the Operational Data Model for metadata, administrative and clinical data in clinical studies. This work suggests a mapping from Operational Data Model to OpenClinica and describes the implementation of a converter to automatically generate OpenClinica conform case report forms based upon metadata in the Operational Data Model.

Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century

PubMed Central

Stoltz, J.-F.; de Isla, N.; Li, Y. P.; Bensoussan, D.; Zhang, L.; Huselstein, C.; Chen, Y.; Decot, V.; Magdalou, J.; Li, N.; Reppel, L.; He, Y.

2015-01-01

Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. Stem cells (SC) with different potency can be isolated and characterised. Despite the promise of embryonic stem cells, in many cases, adult or even fetal stem cells provide a more interesting approach for clinical applications. It is undeniable that mesenchymal stem cells (MSC) from bone marrow, adipose tissue, or Wharton's Jelly are of potential interest for clinical applications in regenerative medicine because they are easily available without ethical problems for their uses. During the last 10 years, these multipotent cells have generated considerable interest and have particularly been shown to escape to allogeneic immune response and be capable of immunomodulatory activity. These properties may be of a great interest for regenerative medicine. Different clinical applications are under study (cardiac insufficiency, atherosclerosis, stroke, bone and cartilage deterioration, diabetes, urology, liver, ophthalmology, and organ's reconstruction). This review focuses mainly on tissue and organ regeneration using SC and in particular MSC. PMID:26300923

The Radioimmunoassay of Fluid and Electrolyte Hormones

NASA Technical Reports Server (NTRS)

Keil, Lanny C.

1985-01-01

The subject of the paper will be the assay of fluid/electrolyte hormones. ADH (antidiuretic hormone also referred to as vasopressin) reduces fluid loss by increasing water reabsorption by the kidney. The stimuli for its release from the pituitary are loss of blood, dehydration, or increased salt intake. Angiotensin II is the next hormone of interest. It is "generated" from a blood protein by the release of renin from the kidney. One of its functions is to stimulate the secretion of aldosterone from the adrenal gland. Release of renin is also stimulated by volume and sodium loss.

Residential Fuel Cell Demonstration Handbook

NASA Astrophysics Data System (ADS)

Torrero, E.; McClelland, R.

2002-07-01

This report is a guide for rural electric cooperatives engaged in field testing of equipment and in assessing related application and market issues. Dispersed generation and its companion fuel cell technology have attracted increased interest by rural electric cooperatives and their customers. In addition, fuel cells are a particularly interesting source because their power quality, efficiency, and environmental benefits have now been coupled with major manufacturer development efforts. The overall effort is structured to measure the performance, durability, reliability, and maintainability of these systems, to identify promising types of applications and modes of operation, and to assess the related prospect for future use. In addition, technical successes and shortcomings will be identified by demonstration participants and manufacturers using real-world experience garnered under typical operating environments.

The evolution of global disaster risk assessments: from hazard to global change

NASA Astrophysics Data System (ADS)

Peduzzi, Pascal

2013-04-01

The perception of disaster risk as a dynamic process interlinked with global change is a fairly recent concept. It gradually emerged as an evolution from new scientific theories, currents of thinking and lessons learned from large disasters since the 1970s. The interest was further heighten, in the mid-1980s, by the Chernobyl nuclear accident and the discovery of the ozone layer hole, both bringing awareness that dangerous hazards can generate global impacts. The creation of the UN International Decade for Natural Disaster Reduction (IDNDR) and the publication of the first IPCC report in 1990 reinforced the interest for global risk assessment. First global risk models including hazard, exposure and vulnerability components were available since mid-2000s. Since then increased computation power and more refined datasets resolution, led to more numerous and sophisticated global risk models. This article presents a recent history of global disaster risk models, the current status of researches for the Global Assessment Report on Disaster Risk Reduction (GAR 2013) and future challenges and limitations for the development of next generation global disaster risk models.

Combining configurational energies and forces for molecular force field optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vlcek, Lukas; Sun, Weiwei; Kent, Paul R. C.

While quantum chemical simulations have been increasingly used as an invaluable source of information for atomistic model development, the high computational expenses typically associated with these techniques often limit thorough sampling of the systems of interest. It is therefore of great practical importance to use all available information as efficiently as possible, and in a way that allows for consistent addition of constraints that may be provided by macroscopic experiments. We propose a simple approach that combines information from configurational energies and forces generated in a molecular dynamics simulation to increase the effective number of samples. Subsequently, this information ismore » used to optimize a molecular force field by minimizing the statistical distance similarity metric. We also illustrate the methodology on an example of a trajectory of configurations generated in equilibrium molecular dynamics simulations of argon and water and compare the results with those based on the force matching method.« less

Combining configurational energies and forces for molecular force field optimization

DOE PAGES

Vlcek, Lukas; Sun, Weiwei; Kent, Paul R. C.

2017-07-21

While quantum chemical simulations have been increasingly used as an invaluable source of information for atomistic model development, the high computational expenses typically associated with these techniques often limit thorough sampling of the systems of interest. It is therefore of great practical importance to use all available information as efficiently as possible, and in a way that allows for consistent addition of constraints that may be provided by macroscopic experiments. We propose a simple approach that combines information from configurational energies and forces generated in a molecular dynamics simulation to increase the effective number of samples. Subsequently, this information ismore » used to optimize a molecular force field by minimizing the statistical distance similarity metric. We also illustrate the methodology on an example of a trajectory of configurations generated in equilibrium molecular dynamics simulations of argon and water and compare the results with those based on the force matching method.« less

Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.

PubMed

Sada, Kiminori; Nishikawa, Takeshi; Kukidome, Daisuke; Yoshinaga, Tomoaki; Kajihara, Nobuhiro; Sonoda, Kazuhiro; Senokuchi, Takafumi; Motoshima, Hiroyuki; Matsumura, Takeshi; Araki, Eiichi

2016-01-01

We previously proposed that hyperglycemia-induced mitochondrial reactive oxygen species (mtROS) generation is a key event in the development of diabetic complications. Interestingly, some common aspects exist between hyperglycemia and hypoxia-induced phenomena. Thus, hyperglycemia may induce cellular hypoxia, and this phenomenon may also be involved in the pathogenesis of diabetic complications. In endothelial cells (ECs), cellular hypoxia increased after incubation with high glucose (HG). A similar phenomenon was observed in glomeruli of diabetic mice. HG-induced cellular hypoxia was suppressed by mitochondria blockades or manganese superoxide dismutase (MnSOD) overexpression, which is a specific SOD for mtROS. Overexpression of MnSOD also increased the expression of aquaporin-1 (AQP1), a water and oxygen channel. AQP1 overexpression in ECs suppressed hyperglycemia-induced cellular hypoxia, endothelin-1 and fibronectin overproduction, and apoptosis. Therefore, hyperglycemia-induced cellular hypoxia and mtROS generation may promote hyperglycemic damage in a coordinated manner.

Flexible operation of batteries in power system scheduling with renewable energy

DOE PAGES

Li, Nan; Uckun, Canan; Constantinescu, Emil M.; ...

2015-12-17

The fast growing expansion of renewable energy increases the complexities in balancing generation and demand in the power system. The energy-shifting and fast-ramping capability of energy storage has led to increasing interests in batteries to facilitate the integration of renewable resources. In this paper, we present a two-step framework to evaluate the potential value of energy storage in power systems with renewable generation. First, we formulate a stochastic unit commitment approach with wind power forecast uncertainty and energy storage. Second, the solution from the stochastic unit commitment is used to derive a flexible schedule for energy storage in economic dispatchmore » where the look-ahead horizon is limited. Here, analysis is conducted on the IEEE 24-bus system to demonstrate the benefits of battery storage in systems with renewable resources and the effectiveness of the proposed battery operation strategy.« less

[Sexuality of our seniors: happy end or new beginning?].

PubMed

Degauquier, C; Absil, A S; Meuris, S; Psalti, I; Jurysta, F

2012-01-01

Comparing surveys from successive periods demonstrates that elderly people now enjoy a better and more varied sexual life than previous generations. The proportion of older people who remain sexually active has significantly increased, and the practices of masturbation or oral sex have spread considerably. The generation effect has an incidence upon sexual behaviour: older people's repertoire of sexual practices differs from that of younger people, in the sense that it focuses less on sexual intercourse and oral sex. Women and men, beyond the common trends towards sexuality characterised by a more open repertoire of sexual practices, differ in terms of sexual interest and subjective sexual wellbeing. The cessation of sexual activity by individuals who had previously been sexually active is often the result of a cascade of reactions, such as the occurrence of a sexual dysfunction in one or both partners, anticipation of failure, increased anxiety, lack of adaptation of sexuality and/or avoidance behaviour.

Heat generation/absorption and nonlinear radiation effects on stagnation point flow of nanofluid along a moving surface

NASA Astrophysics Data System (ADS)

Soomro, Feroz Ahmed; Haq, Rizwan Ul; Al-Mdallal, Qasem M.; Zhang, Qiang

2018-03-01

In this study, heat generation/absorption effects are studied in the presence of nonlinear thermal radiation along a moving slip surface. Uniform magnetic field and convective condition along the stretching surface are adjusted to deal the slip mechanisms in term of Brownian motion and thermophoresis for nanofluid. The mathematical model is constructed in the form of coupled partial differential equations. By introducing the suitable similarity transformation, system of coupled nonlinear ordinary differential equations are obtained. Finite difference approach is implemented to obtain the unknown functions of velocity, temperature, nanoparticle concentration. To deduct the effects at the surface, physical quantities of interest are computed under the effects of controlled physical parameters. Present numerical solutions are validated via numerical comparison with existing published work for limiting cases. Present study indicates that due to increase in both Brownian motion and thermophoresis, the Nusselt number decreases while Sherwood number shows the gradual increase.

Genetic algorithms in teaching artificial intelligence (automated generation of specific algebras)

NASA Astrophysics Data System (ADS)

Habiballa, Hashim; Jendryscik, Radek

2017-11-01

The problem of teaching essential Artificial Intelligence (AI) methods is an important task for an educator in the branch of soft-computing. The key focus is often given to proper understanding of the principle of AI methods in two essential points - why we use soft-computing methods at all and how we apply these methods to generate reasonable results in sensible time. We present one interesting problem solved in the non-educational research concerning automated generation of specific algebras in the huge search space. We emphasize above mentioned points as an educational case study of an interesting problem in automated generation of specific algebras.

An overview of the recovery of acid from spent acidic solutions from steel and electroplating industries.

PubMed

Agrawal, Archana; Sahu, K K

2009-11-15

Every metal and metallurgical industry is associated with the generation of waste, which may be a solid, liquid or gaseous in nature. Their impacts on the ecological bodies are noticeable due to their complex and hazardous nature affecting the living and non-living environment which is an alarming issue to the environmentalist. The increasingly stringent regulations regarding the discharge of acid and metal into the environment, and the increasing stress upon the recycling/reuse of these effluents after proper treatment have focused the interest of the research community on the development of new approaches for the recovery of acid and metals from industrial wastes. This paper is a critical review on the acidic waste streams generated from steel and electroplating industries particularly from waste pickle liquor and spent bleed streams. Various aspects on the generation of these streams and the methods used for their treatment either for the recovery of acid for reuse or disposal are being dealt with. Major stress is laid upon the hydrometallurgical methods such as solvent extraction.

Radiation Sensors for Medical, Industrial and Environmental Applications: How to Engage with Schools and the General Public

ERIC Educational Resources Information Center

Seitz, B.; Rivera, N. Campos; Gray, R.; Power, A.; Thomson, F.

2018-01-01

Radiation, radiation detection and radiation protection are topics in physics and its applications which generate a wide interest in the public. This interest is either generated through medical procedures, applications of nuclear energy or nuclear accidents. The technical nature of these topics usually means that they are not well covered in the…

Generation of Student Interest in an Inquiry-Based Mobile Learning Environment

ERIC Educational Resources Information Center

Laine, Erkka; Veermans, Marjaana; Lahti, Aleksi; Veermans, Koen

2017-01-01

A declining trend in adolescents' interest in science learning and attitudes towards science-related careers has been reported during recent years. There has been a call for more motivating learning environments that inspire students to develop interest towards science. This study examines students' interest development in STEM subjects in an…

Climate change impact on operation of dams and hydroelectricity generation in the Northeastern United States

NASA Astrophysics Data System (ADS)

Ehsani, N.; Vorosmarty, C. J.; Fekete, B. M.

2016-12-01

We are using a large-scale, high-resolution, fully integrated hydrological/reservoir/hydroelectricity model to investigate the impact of climate change on the operation of 11037 dams and generation of electricity from 375 hydroelectric power plants in the Northeastern United States. Moreover, we estimate the hydropower potential of the region by energizing the existing non-powered dams and then studying the impact of climate change on the hydropower potential. We show that climate change increases the impact of dams on the hydrology of the region. Warmer temperatures produce shorter frozen periods, earlier snowmelt and elevated evapotranspiration rates, which when combined with changes in precipitation, are projected to increase water availability in winter but reduce it during summer. As a result, the water that is stored by dams will be more than ever a necessary part of the routine water systems operations to compensate for these seasonal imbalances. The function of dams as emergency water storage for creating drought resiliency will mostly diminish in the future. Building more dams to cope with the local impacts of climate change on water resources and to offset the increased drought vulnerability may thus be inevitable. Annual hydroelectricity generation in the region is 41 Twh. Our estimate of the annual hydropower potential of non-powered dams adds up to 350 Twh. Climate change may reduce hydropower potential from non-powered dams by up to 13% and reduce current hydroelectricity generation by up to 8% annually. Hydroelectricity generation and hydropower potential may increase in winter months and decline in months of summer and fall. These changes call for recalibration of dam operations and may raise conflict of interests in multipurpose dams.

Affective neuroscience of self-generated thought.

PubMed

Fox, Kieran C R; Andrews-Hanna, Jessica R; Mills, Caitlin; Dixon, Matthew L; Markovic, Jelena; Thompson, Evan; Christoff, Kalina

2018-05-12

Despite increasing scientific interest in self-generated thought-mental content largely independent of the immediate environment-there has yet to be any comprehensive synthesis of the subjective experience and neural correlates of affect in these forms of thinking. Here, we aim to develop an integrated affective neuroscience encompassing many forms of self-generated thought-normal and pathological, moderate and excessive, in waking and in sleep. In synthesizing existing literature on this topic, we reveal consistent findings pertaining to the prevalence, valence, and variability of emotion in self-generated thought, and highlight how these factors might interact with self-generated thought to influence general well-being. We integrate these psychological findings with recent neuroimaging research, bringing attention to the neural correlates of affect in self-generated thought. We show that affect in self-generated thought is prevalent, positively biased, highly variable (both within and across individuals), and consistently recruits many brain areas implicated in emotional processing, including the orbitofrontal cortex, amygdala, insula, and medial prefrontal cortex. Many factors modulate these typical psychological and neural patterns, however; the emerging affective neuroscience of self-generated thought must endeavor to link brain function and subjective experience in both everyday self-generated thought as well as its dysfunctions in mental illness. © 2018 New York Academy of Sciences.

HoloHands: games console interface for controlling holographic optical manipulation

NASA Astrophysics Data System (ADS)

McDonald, C.; McPherson, M.; McDougall, C.; McGloin, D.

2012-10-01

The increased application of holographic optical manipulation techniques within the life sciences has sparked the development of accessible interfaces for control of holographic optical tweezers. Of particular interest are those that employ familiar, commercially available technologies. Here we present the use of a low cost games console interface, the Microsoft Kinect for the control of holographic optical tweezers and a study into the effect of using such a system upon the quality of trap generated.

Facile Synthesis of Highly Functionalized Ethyltrifluoroborates

PubMed Central

Molander, Gary A.; Febo-Ayala, Wilma; Ortega-Guerra, Montserrat

2008-01-01

Organotrifluoroborates are generating increased interest because of their ease of preparation and purification, and indefinite shelf-life. Herein we report the preparation of Organotrifluoroborates bearing functional groups that can be manipulated at different stages of the synthetic route, exploiting the inertness of their carbon-boron bonds. The alkylation of 2,2-dicyanoethyltrifluoroborate with a variety of electrophiles and of (EWG)2CH2 with potassium iodomethyltrifluoroborate resulted in di- and trisubstituted ethyltrifluoroborates in good to excellent yields. PMID:18588349

Generation of Strategies for Environmental Deception in Two-Player Normal-Form Games

DTIC Science & Technology

2015-06-18

found in the literature is pre- sented by Kohlberg and Mertens [23]. A stable equilibrium by their definition is an equi- librium in an extensive-form...the equilibrium in this state provides them with an increased payoff. While interesting, Kohlberg and Mertens’ defi- 13 nition of equilibrium...stability used by Kohlberg and Mertens. Arsham’s work focuses on determining the amount by which a mixed-strategy Nash equilibrium’s payoff values can

Tobacco price increases and population interest in smoking cessation in Japan between 2004 and 2016: a Google Trends analysis.

PubMed

Tabuchi, Takahiro; Fukui, Keisuke; Gallus, Silvano

2018-01-31

Tobacco price increases can generate increased public interest in smoking cessation, but it is not clear how long this interest lasts. Our objective was to evaluate the duration of the impact of cigarette price increase in Japan using Google search data. Monthly or daily aggregated Google search volume for smoking cessation in Japan from 2004 to 2016 was collected in terms of relative search volume (RSV) ranging from 0-100. Using monthly RSV data, we evaluated possible relationships between the RSVs and tobacco control measures in Japan. Time periods within which the impact of search volume significantly increased were identified by cluster detection test, using daily RSV data. A spike in RSV preceding the enforcement of a cigarette price increase revealed an anticipation effect. Between 2004 and 2016 the three highest monthly RSV spikes were observed in July 2006 (RSV=66), when cigarette prices increased by 11%, and in September (RSV=90) and October 2010 (RSV=100), when cigarette prices increased by 37%. Regarding daily RSV, the detected cluster size around the price increase in 2010 (52 days) was longer than that in 2006 (17 days). In 2010, a cluster period of 25 days before the date of the price increase was observed, suggesting an anticipation effect. After the onset of the price increase, a cluster of 27 days was detected. When the cigarette price increased due to consumption tax in April 2014, almost no anticipation effect was observed. The population impact of tobacco price increases on smoking cessation may be assessed using Google Trends data. The cluster indicates that a higher cigarette price increase had a higher and longer-lasting effect on population interest in cessation, but the impact may continue for a relatively short time. To examine the duration of the impact of cigarette price increases on population interest in smoking cessation in Japan, Google search data for smoking cessation was analyzed. Between 2004 and 2016 the three highest spikes of monthly relative search volume (RSV) were observed in October 2010, when cigarette prices increased by 37%. Analyzing daily RSV data, the detected cluster size around the price increase in 2010 was 52 days and a cluster period of 25 days before the date of the price increase was observed, suggesting an anticipation effect. The cluster indicates that a higher cigarette price increase had a higher and longer-lasting effect, but the population impact continues for a relatively short time. Further increases in the price of cigarettes are necessary. © The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Generation of lycopene-overproducing strains of the fungus Mucor circinelloides reveals important aspects of lycopene formation and accumulation.

PubMed

Zhang, Yingtong; Chen, Haiqin; Navarro, Eusebio; López-García, Sergio; Chen, Yong Q; Zhang, Hao; Chen, Wei; Garre, Victoriano

2017-03-01

To generate lycopene-overproducing strains of the fungus Mucor circinelloides with interest for industrial production and to gain insight into the catalytic mechanism of lycopene cyclase and regulatory process during lycopene overaccumulation. Three lycopene-overproducing mutants were generated by classic mutagenesis techniques from a β-carotene-overproducing strain. They carried distinct mutations in the carRP gene encoding lycopene cyclase that produced loss of enzymatic activity to different extents. In one mutant (MU616), the lycopene cyclase was completely destroyed, and a 43.8% (1.1 mg/g dry mass) increase in lycopene production was observed in comparison to that by the previously existing lycopene overproducer. In addition, feedback regulation of the end product was suggested in lycopene-overproducing strains. A lycopene-overaccumulating strain of the fungus M. circinelloides was generated that could be an alternative for the industrial production of lycopene. Vital catalytic residues for lycopene cyclase activity and the potential mechanism of lycopene formation and accumulation were identified.

Generations of even-order harmonics from vibrating H2+ and T2+ in the rising and falling parts of the laser field

NASA Astrophysics Data System (ADS)

Feng, Liqiang; Kapteyn, Henry J.; Feng, April Y.

2018-04-01

The generations of the even-order harmonics from H2+ and one of its isotope T2+ have been theoretically investigated beyond the Born-Oppenheimer approximation. Normally, the high-order harmonic generation (HHG) only contains odd-order harmonics for the orbital symmetry along the direction of laser polarization. Here, we showed that due to asymmetric harmonic emission (asymmetric half-wave profile), the even-order harmonics can be generated in the rising and the falling part of the laser field. In detail, in the lower initial vibrational state, the even-order harmonics main come from the falling part of the laser field; while as the initial vibrational state increases, the identified even-order harmonics in the falling part of the laser field are decreased; while some other even-order harmonics coming from the rising part of the laser field can be produced. The interesting phenomena have been proved through studying the spatial distributions and the time profiles of the HHG.

Three-dimensional direct observation of Gouy phase shift in a terajet produced by a dielectric cuboid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen Pham, Hai Huy, E-mail: haihuynguyenpham135@s.ee.es.osaka-u.ac.jp; Hisatake, Shintaro, E-mail: hisatake@ee.es.osaka-u.ac.jp; Nagatsuma, Tadao, E-mail: nagatuma@ee.es.osaka-u.ac.jp

2016-05-09

The generation of the terajet at the terahertz (THz) frequency with the capability of subwavelength beam-compression has been attracting increasing research interest, as did the generation of the nanojet at the optical frequency. In particular, a terajet generated from a dielectric cuboid was not previously studied experimentally in the THz region. We here experimentally demonstrate three-dimensional visualizations and characterization of a terajet generated from a dielectric cuboid with a refractive index of n = 1.46 at 125 GHz. The subwavelength compressed beam and the Gouy phase shift phenomena of the terajet are directly observed. It is also found out that a calculation modelmore » of Gouy phase shift based on focused Gaussian beam by a lens cannot explain the Gouy phase shift of compressed beam by the terajet. The intensity enhancement of about 7.4 dB and full width at half maximum of 0.6λ are obtained at the distance 0.5λ from the cuboid.« less

Federal Geothermal Research Program Update - Fiscal Year 2004

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patrick Laney

2005-03-01

The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. The Geothermal Technologies Program (GTP) works in partnership with industry to establish geothermal energy as an economically competitive contributor to the U.S. energy supply. Geothermal energy production, a $1.5 billion a year industry, generates electricity or provides heat for direct use applications. The technologies developed by the Geothermal Technologies Program will provide the Nation with new sources of electricity that are highly reliable and cost competitive and do not add to America's air pollution or the emission of greenhouse gases. Geothermalmore » electricity generation is not subject to fuel price volatility and supply disruptions from changes in global energy markets. Geothermal energy systems use a domestic and renewable source of energy. The Geothermal Technologies Program develops innovative technologies to find, access, and use the Nation's geothermal resources. These efforts include emphasis on Enhanced Geothermal Systems (EGS) with continued R&D on geophysical and geochemical exploration technologies, improved drilling systems, and more efficient heat exchangers and condensers. The Geothermal Technologies Program is balanced between short-term goals of greater interest to industry, and long-term goals of importance to national energy interests. The program's research and development activities are expected to increase the number of new domestic geothermal fields, increase the success rate of geothermal well drilling, and reduce the costs of constructing and operating geothermal power plants. These improvements will increase the quantity of economically viable geothermal resources, leading in turn to an increased number of geothermal power facilities serving more energy demand. These new geothermal projects will take advantage of geothermal resources in locations where development is not currently possible or economical.« less

Federal Geothermal Research Program Update Fiscal Year 2004

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

2005-03-01

The Department of Energy (DOE) and its predecessors have conducted research and development (R&D) in geothermal energy since 1971. The Geothermal Technologies Program (GTP) works in partnership with industry to establish geothermal energy as an economically competitive contributor to the U.S. energy supply. Geothermal energy production, a $1.5 billion a year industry, generates electricity or provides heat for direct use applications. The technologies developed by the Geothermal Technologies Program will provide the Nation with new sources of electricity that are highly reliable and cost competitive and do not add to America's air pollution or the emission of greenhouse gases. Geothermalmore » electricity generation is not subject to fuel price volatility and supply disruptions from changes in global energy markets. Geothermal energy systems use a domestic and renewable source of energy. The Geothermal Technologies Program develops innovative technologies to find, access, and use the Nation's geothermal resources. These efforts include emphasis on Enhanced Geothermal Systems (EGS) with continued R&D on geophysical and geochemical exploration technologies, improved drilling systems, and more efficient heat exchangers and condensers. The Geothermal Technologies Program is balanced between short-term goals of greater interest to industry, and long-term goals of importance to national energy interests. The program's research and development activities are expected to increase the number of new domestic geothermal fields, increase the success rate of geothermal well drilling, and reduce the costs of constructing and operating geothermal power plants. These improvements will increase the quantity of economically viable geothermal resources, leading in turn to an increased number of geothermal power facilities serving more energy demand. These new geothermal projects will take advantage of geothermal resources in locations where development is not currently possible or economical.« less

Development and Simulation of Increased Generation on a Secondary Circuit of a Microgrid

NASA Astrophysics Data System (ADS)

Reyes, Karina

As fossil fuels are depleted and their environmental impacts remain, other sources of energy must be considered to generate power. Renewable sources, for example, are emerging to play a major role in this regard. In parallel, electric vehicle (EV) charging is evolving as a major load demand. To meet reliability and resiliency goals demanded by the electricity market, interest in microgrids are growing as a distributed energy resource (DER). In this thesis, the effects of intermittent renewable power generation and random EV charging on secondary microgrid circuits are analyzed in the presence of a controllable battery in order to characterize and better understand the dynamics associated with intermittent power production and random load demands in the context of the microgrid paradigm. For two reasons, a secondary circuit on the University of California, Irvine (UCI) Microgrid serves as the case study. First, the secondary circuit (UC-9) is heavily loaded and an integral component of a highly characterized and metered microgrid. Second, a unique "next-generation" distributed energy resource has been deployed at the end of the circuit that integrates photovoltaic power generation, battery storage, and EV charging. In order to analyze this system and evaluate the impact of the DER on the secondary circuit, a model was developed to provide a real-time load flow analysis. The research develops a power management system applicable to similarly integrated systems. The model is verified by metered data obtained from a network of high resolution electric meters and estimated load data for the buildings that have unknown demand. An increase in voltage is observed when the amount of photovoltaic power generation is increased. To mitigate this effect, a constant power factor is set. Should the real power change dramatically, the reactive power is changed to mitigate voltage fluctuations.

Investigating Turkish Primary School Students' Interest in Science by Using Their Self-Generated Questions

NASA Astrophysics Data System (ADS)

Cakmakci, Gultekin; Sevindik, Hatice; Pektas, Meryem; Uysal, Asli; Kole, Fatma; Kavak, Gamze

2012-06-01

This paper reports on an attempt to investigate Turkish primary school students' interest in science by using their self-generated questions. We investigated students' interest in science by analyzing 1704 self-generated science-related questions. Among them, 826 questions were submitted to a popular science magazine called Science and Children. Such a self-selected sample may represent a group of students who have a higher level of motivation to seek sources of information outside their formal education and have more access to resources than the students of low social classes. To overcome this problem, 739 students were asked to write a question that they wanted to learn from a scientist and as a result 878 questions were gathered. Those students were selected from 13 different schools at 9 cities in Turkey. These schools were selected to represent a mixture of socioeconomic areas and also to cover different students' profile. Students' questions were classified into two main categories: the field of interest and the cognitive level of the question. The results point to the popularity of biology, astrophysics, nature of scientific inquiry, technology and physics over other science areas, as well as indicating a difference in interest according to gender, grade level and the setting in which the questions were asked. However, our study suggests that only considering questions submitted to informal learning environments, such as popular science magazines or Ask-A-Scientist Internet sites has limitations and deficiencies. Other methodologies of data collection also need to be considered in designing teaching and school science curriculum to meet students' needs and interest. The findings from our study tend to challenge existing thinking from other studies. Our results show that self-generated questions asked in an informal and a formal setting have different patterns. Some aspects of students' self-generated questions and their implications for policy, science curriculum reform and teaching are discussed in this paper.

Evaluation of atlas-based auto-segmentation software in prostate cancer patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenham, Stuart, E-mail: stuart.greenham@ncahs.health.nsw.gov.au; Dean, Jenna; Fu, Cheuk Kuen Kenneth

2014-09-15

The performance and limitations of an atlas-based auto-segmentation software package (ABAS; Elekta Inc.) was evaluated using male pelvic anatomy as the area of interest. Contours from 10 prostate patients were selected to create atlases in ABAS. The contoured regions of interest were created manually to align with published guidelines and included the prostate, bladder, rectum, femoral heads and external patient contour. Twenty-four clinically treated prostate patients were auto-contoured using a randomised selection of two, four, six, eight or ten atlases. The concordance between the manually drawn and computer-generated contours were evaluated statistically using Pearson's product–moment correlation coefficient (r) and clinicallymore » in a validated qualitative evaluation. In the latter evaluation, six radiation therapists classified the degree of agreement for each structure using seven clinically appropriate categories. The ABAS software generated clinically acceptable contours for the bladder, rectum, femoral heads and external patient contour. For these structures, ABAS-generated volumes were highly correlated with ‘as treated’ volumes, manually drawn; for four atlases, for example, bladder r = 0.988 (P < 0.001), rectum r = 0.739 (P < 0.001) and left femoral head r = 0.560 (P < 0.001). Poorest results were seen for the prostate (r = 0.401, P < 0.05) (four atlases); however this was attributed to the comparison prostate volume being contoured on magnetic resonance imaging (MRI) rather than computed tomography (CT) data. For all structures, increasing the number of atlases did not consistently improve accuracy. ABAS-generated contours are clinically useful for a range of structures in the male pelvis. Clinically appropriate volumes were created, but editing of some contours was inevitably required. The ideal number of atlases to improve generated automatic contours is yet to be determined.« less

Derivative financial instruments and nonprofit health care providers.

PubMed

Stewart, Louis J; Owhoso, Vincent

2004-01-01

This article examines the extent of derivative financial instrument use among US nonprofit health systems and the impact of these financial instruments on their cash flows, reported operating results, and financial risks. Our examination is conducted through a case study of New Jersey hospitals and health systems. We review the existing literature on interest rate derivative instruments and US hospitals and health systems. This literature describes the design of these derivative financial instruments and the theoretical benefits of their use by large health care provider organizations. Our contribution to the literature is to provide an empirical evaluation of derivative financial instruments usage among a geographically limited sample of US nonprofit health systems. We reviewed the audited financial statements of the 49 community hospitals and multi-hospital health systems operating in the state of New Jersey. We found that 8 percent of New Jersey's nonprofit health providers utilized interest rate derivatives with an aggregate principle value of $229 million. These derivative users combine interest rate swaps and caps to lower the effective interest costs of their long-term debt while limiting their exposure to future interest rate increases. In addition, while derivative assets and liabilities have an immaterial balance sheet impact, derivative related gains and losses are a material component of their reported operating results. We also found that derivative usage among these four health systems was responsible for generating positive cash flows in the range of 1 percent to 2 percent of their total 2001 cash flows from operations. As a result of our admittedly limited samples we conclude that interest rate swaps and caps are effective risk management tools. However, we also found that while these derivative financial instruments are useful hedges against the risks of issuing long-term financing instruments, they also expose derivative users to credit, contract termination and interest rate volatility risks. In conclusion, we find that these financial instruments can also generate negative as well as positive cash flows and have both a positive and negative impact on reported operating results.

Obesity in the Transition to Adulthood: Predictions across Race-Ethnicity, Immigrant Generation, and Sex

PubMed Central

Harris, Kathleen Mullan; Perreira, Krista; Lee, Dohoon

2009-01-01

Objectives With longitudinal data we traced how race, ethnic, and immigrant disparities in body mass index (BMI) change over time as adolescents (ages 11–19) transition to young adulthood (ages 20–28). Design We used growth curve modeling to estimate the pattern of change in BMI from adolescence through the transition to adulthood. Setting All participants in the study were residents of the United States enrolled in high school or junior high school during the 1994–95 school year. Participants We used nationally representative data on 20,000+ adolescents interviewed at Wave I (1994–95) of Add Health, followed in Wave II (1996) and Wave III (2001–02) when the sample was in early adulthood. Main Exposure(s) Exposures of interest include race-ethnicity, immigrant generation, and sex. Main Outcome Measure(s) Our main outcome measure is BMI. Results Findings indicate significant differences in both the level and change in BMI across age by sex, race-ethnicity, and immigrant generation. Females, second and third generation immigrants, and Hispanics and blacks experience more rapidly increasing BMI as adolescents age into young adulthood. Increases in BMI are relatively lower for males, first generation immigrants, and whites and Asians. Conclusions Disparities in BMI and percent overweight and obese widen with age as adolescents leave home and begin independent lives as young adults in their 20s. PMID:19884593

Hybrid generative-discriminative human action recognition by combining spatiotemporal words with supervised topic models

NASA Astrophysics Data System (ADS)

Sun, Hao; Wang, Cheng; Wang, Boliang

2011-02-01

We present a hybrid generative-discriminative learning method for human action recognition from video sequences. Our model combines a bag-of-words component with supervised latent topic models. A video sequence is represented as a collection of spatiotemporal words by extracting space-time interest points and describing these points using both shape and motion cues. The supervised latent Dirichlet allocation (sLDA) topic model, which employs discriminative learning using labeled data under a generative framework, is introduced to discover the latent topic structure that is most relevant to action categorization. The proposed algorithm retains most of the desirable properties of generative learning while increasing the classification performance though a discriminative setting. It has also been extended to exploit both labeled data and unlabeled data to learn human actions under a unified framework. We test our algorithm on three challenging data sets: the KTH human motion data set, the Weizmann human action data set, and a ballet data set. Our results are either comparable to or significantly better than previously published results on these data sets and reflect the promise of hybrid generative-discriminative learning approaches.

Identifying Underlying Causes of Situational Interest in a Science Course for Preservice Elementary Teachers

ERIC Educational Resources Information Center

Palmer, David H.; Dixon, Jeanette; Archer, Jennifer

2016-01-01

Situational interest is short-term interest that is linked to environmental factors in a particular situation. Previous studies have found that some science teaching techniques can be very effective in generating situational interest among students, but the reasons why these are effective remain unclear: Hands-on activities, for example, are known…

Diversity of fuel sources for electricity generation in an evolving U.S. power sector

NASA Astrophysics Data System (ADS)

DiLuccia, Janelle G.

Policymakers increasingly have shown interest in options to boost the relative share of renewable or clean electricity generating sources in order to reduce negative environmental externalities from fossil fuels, guard against possible resource constraints, and capture economic advantages from developing new technologies and industries. Electric utilities and non-utility generators make decisions regarding their generation mix based on a number of different factors that may or may not align with societal goals. This paper examines the makeup of the electric power sector to determine how the type of generator and the presence (or lack) of competition in electricity markets at the state level may relate to the types of fuel sources used for generation. Using state-level electricity generation data from the U.S. Energy Information Administration from 1990 through 2010, this paper employs state and time fixed-effects regression modeling to attempt to isolate the impacts of state-level restructuring policies and the emergence of non-utility generators on states' generation from coal, from fossil fuel and from renewable sources. While the analysis has significant limitations, I do find that state-level electricity restructuring has a small but significant association with lowering electricity generation from coal specifically and fossil fuels more generally. Further research into the relationship between competition and fuel sources would aid policymakers considering legislative options to influence the generation mix.

Women, Minorities, and Interdisciplinary Research

NASA Astrophysics Data System (ADS)

Pfirman, S.; Rhoten, D.

2007-05-01

Two major issues face the scientific enterprise: the need to engage the next generation of scientists and the recognition that research frontiers don't necessarily fall within disciplinary lines. While research has focused on each of these trends independently, surprisingly few studies have considered how intellectual preferences for and professional consequences of interdisciplinary science might be influenced by one's gender. This presentation assembles some of the first empirical data on gender and interdisciplinarity, showing that women appear to be disproportionately involved in interdisciplinary science. It considers what draws women in this direction and explores the implications of such a tendency. Interdisciplinary research may present a promising angle by which to engage women in the scientific enterprise, and institutions interested in increasing interdisciplinary research may have a greater chance for success if they involve women. Similarly, institutions interested in increasing their diversity may have a greater chance for success if they value interdisciplinary scholarship, which is still an issue on most campuses where disciplinary departments dominate.

Cyanobacteria and microalgae: a positive prospect for biofuels.

PubMed

Parmar, Asha; Singh, Niraj Kumar; Pandey, Ashok; Gnansounou, Edgard; Madamwar, Datta

2011-11-01

Biofuel-bioenergy production has generated intensive interest due to increased concern regarding limited petroleum-based fuel supplies and their contribution to atmospheric CO2 levels. Biofuel research is not just a matter of finding the right type of biomass and converting it to fuel, but it must also be economically sustainable on large-scale. Several aspects of cyanobacteria and microalgae such as oxygenic photosynthesis, high per-acre productivity, non-food based feedstock, growth on non-productive and non-arable land, utilization of wide variety of water sources (fresh, brackish, seawater and wastewater) and production of valuable co-products along with biofuels have combined to capture the interest of researchers and entrepreneurs. Currently, worldwide biofuels mainly in focus include biohydrogen, bioethanol, biodiesel and biogas. This review focuses on cultivation and harvesting of cyanobacteria and microalgae, possible biofuels and co-products, challenges for cyanobacterial and microalgal biofuels and the approaches of genetic engineering and modifications to increase biofuel production. Copyright © 2011 Elsevier Ltd. All rights reserved.

The moderating role of absorptive capacity and the differential effects of acquisitions and alliances on Big Pharma firms' innovation performance.

PubMed

Fernald, K D S; Pennings, H P G; van den Bosch, J F; Commandeur, H R; Claassen, E

2017-01-01

In the context of increased pharmaceutical innovation deficits and Big Pharma blockbusters' patent expirations, this paper examines the moderating role of firms' absorptive capacity in external innovation activities of Big Pharma firms. The study indicates a rising interest of Big Pharma in acquisitions of and alliances with biotechnology companies. Unfortunately, this increased interest is not reflected in the number of new drugs generated by Big Pharma. We find that acquisitions of biotech companies have negatively affected Big Pharma firms' innovation performance on average but these acquisitions might have a positive effect at higher levels of acquiring firms' absorptive capacity. Moreover, also acquisitions of pharma companies and alliances with biotech companies only have a positive effect on innovation performance at sufficiently high levels of absorptive capacity. The moderating role of absorptive capacity implicates that a tight integration of internal R&D efforts and (unrelated) external knowledge is crucial for harnessing complementarity effects.

The moderating role of absorptive capacity and the differential effects of acquisitions and alliances on Big Pharma firms' innovation performance

PubMed Central

Fernald, K. D. S.; Pennings, H. P. G.; van den Bosch, J. F.; Commandeur, H. R.; Claassen, E.

2017-01-01

In the context of increased pharmaceutical innovation deficits and Big Pharma blockbusters’ patent expirations, this paper examines the moderating role of firms’ absorptive capacity in external innovation activities of Big Pharma firms. The study indicates a rising interest of Big Pharma in acquisitions of and alliances with biotechnology companies. Unfortunately, this increased interest is not reflected in the number of new drugs generated by Big Pharma. We find that acquisitions of biotech companies have negatively affected Big Pharma firms’ innovation performance on average but these acquisitions might have a positive effect at higher levels of acquiring firms’ absorptive capacity. Moreover, also acquisitions of pharma companies and alliances with biotech companies only have a positive effect on innovation performance at sufficiently high levels of absorptive capacity. The moderating role of absorptive capacity implicates that a tight integration of internal R&D efforts and (unrelated) external knowledge is crucial for harnessing complementarity effects. PMID:28231332

Catalyst-controlled oligomerization for the collective synthesis of polypyrroloindoline natural products.

PubMed

Jamison, Christopher R; Badillo, Joseph J; Lipshultz, Jeffrey M; Comito, Robert J; MacMillan, David W C

2017-12-01

In nature, many organisms generate large families of natural product metabolites that have related molecular structures as a means to increase functional diversity and gain an evolutionary advantage against competing systems within the same environment. One pathway commonly employed by living systems to generate these large classes of structurally related families is oligomerization, wherein a series of enzymatically catalysed reactions is employed to generate secondary metabolites by iteratively appending monomers to a growing serial oligomer chain. The polypyrroloindolines are an interesting class of oligomeric natural products that consist of multiple cyclotryptamine subunits. Herein we describe an iterative application of asymmetric copper catalysis towards the synthesis of six distinct oligomeric polypyrroloindoline natural products: hodgkinsine, hodgkinsine B, idiospermuline, quadrigemine H and isopsychotridine B and C. Given the customizable nature of the small-molecule catalysts employed, we demonstrate that this strategy is further amenable to the construction of quadrigemine H-type alkaloids not isolated previously from natural sources.

Catalyst-controlled oligomerization for the collective synthesis of polypyrroloindoline natural products

NASA Astrophysics Data System (ADS)

Jamison, Christopher R.; Badillo, Joseph J.; Lipshultz, Jeffrey M.; Comito, Robert J.; MacMillan, David W. C.

2017-12-01

In nature, many organisms generate large families of natural product metabolites that have related molecular structures as a means to increase functional diversity and gain an evolutionary advantage against competing systems within the same environment. One pathway commonly employed by living systems to generate these large classes of structurally related families is oligomerization, wherein a series of enzymatically catalysed reactions is employed to generate secondary metabolites by iteratively appending monomers to a growing serial oligomer chain. The polypyrroloindolines are an interesting class of oligomeric natural products that consist of multiple cyclotryptamine subunits. Herein we describe an iterative application of asymmetric copper catalysis towards the synthesis of six distinct oligomeric polypyrroloindoline natural products: hodgkinsine, hodgkinsine B, idiospermuline, quadrigemine H and isopsychotridine B and C. Given the customizable nature of the small-molecule catalysts employed, we demonstrate that this strategy is further amenable to the construction of quadrigemine H-type alkaloids not isolated previously from natural sources.

Out-of-water constitutional self-organization of chitosan-cinnamaldehyde dynagels.

PubMed

Marin, Luminita; Moraru, Simona; Popescu, Maria-Cristina; Nicolescu, Alina; Zgardan, Cristina; Simionescu, Bogdan C; Barboiu, Mihail

2014-04-14

An investigation of the constitutional adaptive gelation process of chitosan/cinnamaldehyde (C/Cy) dynagels is reported. These gels generate timely variant macroscopic organization across extended scales. In the first stage, imine-bond formation takes place "in-water" and generates low-ordered hydrogels. The progressive formation of imine bonds further induces "out-of-water" increased reactivity within interdigitated hydrophobic self-assembled layers of Cy, with a protecting environmental effect against hydrolysis and that leads to the stabilization of the imine bonds. The hydrophobic swelling due to Cy layers at the interfaces reaches a critical step when lamellar self-organized hybrids are generated (24 hours). This induces an important restructuration of the hydrogels on the micrometric scale, thus resulting in the formation of highly ordered microporous xerogel morphologies of high potential interest for chemical separations, drug delivery, and sensors. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

An assessment of potential CO2 Sources throughout the Illinois Basin Subtask 5.1 – CO2 Source Assessment Topical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patel, Vinodkumar; O?Brien, Kevin; Korose, Christopher

Large-scale anthropogenic CO2 sources (>100,000 tonnes/year) were catalogued and assessed for the Illinois East Sub-Basin project area. The portfolio of sources is quite diverse, and contains not only fossil-based power generation facilities but also ethanol, chemical, and refinery facilities. Over 60% of the facilities are relatively new (i.e. post year 2000 construction) hence increasing the likelihood that retrofitting the facility with a carbon capture plant is feasible. Two of the facilities have indicated interest in being “early adopters” should the CarbonSAFE project eventually transition to a build and operate phase: the Prairie State Generating Company’s electricity generation facility near Marissa,more » Illinois, and Quasar Syngas, LLC’s Wabash ammonia/direct-reduced iron plant, currently in development north of Terre Haute, Indiana.« less

The second phase in creating the cardiac center for the next generation: beyond structure to process improvement.

PubMed

Woods, J

2001-01-01

The third generation cardiac institute will build on the successes of the past in structuring the service line, re-organizing to assimilate specialist interests, and re-positioning to expand cardiac services into cardiovascular services. To meet the challenges of an increasingly competitive marketplace and complex delivery system, the focus for this new model will shift away from improved structures, and toward improved processes. This shift will require a sound methodology for statistically measuring and sustaining process changes related to the optimization of cardiovascular care. In recent years, GE Medical Systems has successfully applied Six Sigma methodologies to enable cardiac centers to control key clinical and market development processes through its DMADV, DMAIC and Change Acceleration processes. Data indicates Six Sigma is having a positive impact within organizations across the United States, and when appropriately implemented, this approach can serve as a solid foundation for building the next generation cardiac institute.

Predicting the math/science career goals of low-income prospective first-generation college students.

PubMed

Garriott, Patton O; Flores, Lisa Y; Martens, Matthew P

2013-04-01

The present study used social cognitive career theory (SCCT; Lent, Brown, & Hackett, 1994) to predict the math/science goal intentions of a sample of low-income prospective first-generation college students (N = 305). Structural equation modeling was used to test a model depicting relationships between contextual (i.e., social class, learning experiences, proximal supports and barriers) and person-cognitive (i.e., self-efficacy, outcome expectations, interests, goals) variables as hypothesized in SCCT and based on previous literature on low-income first-generation college students. Results indicated that the hypothesized model provided the best representation of the data. All paths in the model were statistically significant, with the exceptions of paths from self-efficacy to goals, outcome expectations to interests, and perceived barriers to self-efficacy. Bootstrapping procedures revealed that the relationships between social class, self-efficacy, and outcome expectations were mediated through learning experiences. Furthermore, the relationship between social supports and goals was mediated by self-efficacy and interests and the relationships between self-efficacy, outcome expectations, and goals were mediated by interests. Contrary to hypotheses, the relationship between barriers and goals was not mediated by self-efficacy and interests. The hypothesis that proximal contextual supports and barriers would moderate the relationship between interests and goals was not supported. The final model explained 66% and 55% of the variance in math/science interests and goals, respectively. Implications for future research and practice are discussed.

Very low-dose (0.15 mGy) chest CT protocols using the COPDGene 2 test object and a third-generation dual-source CT scanner with corresponding third-generation iterative reconstruction software.

PubMed

Newell, John D; Fuld, Matthew K; Allmendinger, Thomas; Sieren, Jered P; Chan, Kung-Sik; Guo, Junfeng; Hoffman, Eric A

2015-01-01

The purpose of this study was to evaluate the impact of ultralow radiation dose single-energy computed tomographic (CT) acquisitions with Sn prefiltration and third-generation iterative reconstruction on density-based quantitative measures of growing interest in phenotyping pulmonary disease. The effects of both decreasing dose and different body habitus on the accuracy of the mean CT attenuation measurements and the level of image noise (SD) were evaluated using the COPDGene 2 test object, containing 8 different materials of interest ranging from air to acrylic and including various density foams. A third-generation dual-source multidetector CT scanner (Siemens SOMATOM FORCE; Siemens Healthcare AG, Erlangen, Germany) running advanced modeled iterative reconstruction (ADMIRE) software (Siemens Healthcare AG) was used.We used normal and very large body habitus rings at dose levels varying from 1.5 to 0.15 mGy using a spectral-shaped (0.6-mm Sn) tube output of 100 kV(p). Three CT scans were obtained at each dose level using both rings. Regions of interest for each material in the test object scans were automatically extracted. The Hounsfield unit values of each material using weighted filtered back projection (WFBP) at 1.5 mGy was used as the reference value to evaluate shifts in CT attenuation at lower dose levels using either WFBP or ADMIRE. Statistical analysis included basic statistics, Welch t tests, multivariable covariant model using the F test to assess the significance of the explanatory (independent) variables on the response (dependent) variable, and CT mean attenuation, in the multivariable covariant model including reconstruction method. Multivariable regression analysis of the mean CT attenuation values showed a significant difference with decreasing dose between ADMIRE and WFBP. The ADMIRE has reduced noise and more stable CT attenuation compared with WFBP. There was a strong effect on the mean CT attenuation values of the scanned materials for ring size (P < 0.0001) and dose level (P < 0.0001). The number of voxels in the region of interest for the particular material studied did not demonstrate a significant effect (P > 0.05). The SD was lower with ADMIRE compared with WFBP at all dose levels and ring sizes (P < 0.05). The third-generation dual-source CT scanners using third-generation iterative reconstruction methods can acquire accurate quantitative CT images with acceptable image noise at very low-dose levels (0.15 mGy). This opens up new diagnostic and research opportunities in CT phenotyping of the lung for developing new treatments and increased understanding of pulmonary disease.

Control of mobility in molecular organic semiconductors by dendrimer generation

NASA Astrophysics Data System (ADS)

Lupton, J. M.; Samuel, I. D.; Beavington, R.; Frampton, M. J.; Burn, P. L.; Bässler, H.

2001-04-01

Conjugated dendrimers are of interest as novel materials for light-emitting diodes. They consist of a luminescent chromophore at the core with highly branched conjugated dendron sidegroups. In these materials, light emission occurs from the core and is independent of generation. The dendron branching controls the separation between the chromophores. We present here a family of conjugated dendrimers and investigate the effect of dendron branching on light emission and charge transport. We apply a number of transport measurement techniques to thin films of a conjugated dendrimer in a light-emitting diode configuration to determine the effect of chromophore spacing on charge transport. We find that the mobility is reduced by two orders of magnitude as the size of the molecule doubles with increased branching or dendrimer generation. The degree of branching allows a unique control of mobility by molecular structure. An increase in chromophore separation also results in a reduction of intermolecular interactions, which reduces the red emission tail in film photoluminescence. We find that the steady-state charge transport is well described by a simple device model incorporating the effect of generation, and use the materials to shed light on the interpretation of transient electroluminescence data. We demonstrate the significance of the ability to tune the mobility in bilayer devices, where a more balanced charge transport can be achieved.

Client-Side Event Processing for Personalized Web Advertisement

NASA Astrophysics Data System (ADS)

Stühmer, Roland; Anicic, Darko; Sen, Sinan; Ma, Jun; Schmidt, Kay-Uwe; Stojanovic, Nenad

The market for Web advertisement is continuously growing and correspondingly, the number of approaches that can be used for realizing Web advertisement are increasing. However, current approaches fail to generate very personalized ads for a current Web user that is visiting a particular Web content. They mainly try to develop a profile based on the content of that Web page or on a long-term user's profile, by not taking into account current user's preferences. We argue that by discovering a user's interest from his current Web behavior we can support the process of ad generation, especially the relevance of an ad for the user. In this paper we present the conceptual architecture and implementation of such an approach. The approach is based on the extraction of simple events from the user interaction with a Web page and their combination in order to discover the user's interests. We use semantic technologies in order to build such an interpretation out of many simple events. We present results from preliminary evaluation studies. The main contribution of the paper is a very efficient, semantic-based client-side architecture for generating and combining Web events. The architecture ensures the agility of the whole advertisement system, by complexly processing events on the client. In general, this work contributes to the realization of new, event-driven applications for the (Semantic) Web.

Research on the coordination framework for water resources utilization on the interests of mutual compensation in Lancang-Mekong River

NASA Astrophysics Data System (ADS)

Wang, Y.; Fang, D., VI; Xu, J.; Dong, Q.

2017-12-01

The Lancang-Mekong River is an important international river, cascaded hydropower stations development in which attracts the attention of downstream countries. In this paper, we proposed a coordination framework for water resources utilization on the interests of mutual compensation to relieve the conflict of upstream and downstream countries. Firstly, analyze the benefits and risks caused by the cascaded hydropower stations development and the evolution process of water resources use conflict between upstream and downstream countries. Secondly, evaluate the benefits and risks of flood control, water supply, navigation and power generation based on the energy theory of cascaded hydropower stations development in Lancang-Mekong River. Thirdly, multi-agent cooperation motivation and cooperation conditions between upstream and downstream countries in Lancang-Mekong River is given. Finally, the coordination framework for water resources utilization on the interests of mutual compensation in Lancang-Mekong River is presented. This coordination framework for water resources utilization can increase comprehensive benefits in Lancang-Mekong River.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baone, Chaitanya; Acharya, Naresh; Wiegman, Herman

As microgrid installations are steadily growing in the United States and around the world, widespread adoption of commercial microgrids would rely upon the economic benefit to the owners and operators. With the introduction of new market mechanisms and growing penetration of non-traditional generation assets, there is an increasing need and interest in allowing distributed assets to participate in traditional grid services such as frequency regulation. This paper considers the problem of determining the optimal balance of energy and ancillary services for individual microgrid generation assets to participate in such markets. An optimization framework that maximizes the predicted performance of themore » microgrid over a day-ahead time horizon while accounting for individual asset constraints is proposed. Simulation results on a realistic test system with practical considerations are presented.« less

Direct Absorption Spectroscopy with Electro-Optic Frequency Combs

NASA Astrophysics Data System (ADS)

Fleisher, Adam J.; Long, David A.; Plusquellic, David F.; Hodges, Joseph T.

2017-06-01

The application of electro-optic frequency combs to direct absorption spectroscopy has increased research interest in high-agility, modulator-based comb generation. This talk will review common architectures for electro-optic frequency comb generators as well as describe common self-heterodyne and multi-heterodyne (i.e., dual-comb) detection approaches. In order to achieve a sufficient signal-to-noise ratio on the recorded interferogram while allowing for manageable data volumes, broadband electro-optic frequency combs require deep coherent averaging, preferably in real-time. Applications such as cavity-enhanced spectroscopy, precision atomic and molecular spectroscopy, as well as time-resolved spectroscopy will be introduced. D.A. Long et al., Opt. Lett. 39, 2688 (2014) A.J. Fleisher et al., Opt. Express 24, 10424 (2016)

Recent advances in female sexual dysfunction.

PubMed

Davis, A R

2000-06-01

Female sexuality has received little scientific study. Recently, increased interest in this field has generated new research in the epidemiology, pathophysiology, and pharmacotherapy of female sexual dysfunction (FSD). A new FSD classification system has been proposed. Although sexual difficulties are highly prevalent among women, the degree of associated distress is unknown. Risk factors for FSD are probably both psychologic and physiologic. Aging or menopause is associated with lubrication difficulties, which can be treated with hormone replacement. Hysterectomy seems more likely to result in improvement rather then deterioration of sexual functioning. Depression may be a predictor of sexual dysfunction after hysterectomy. Vasoactive agents are currently being evaluated as treatment for female sexual arousal disorder. The most important advance in the study of female sexual function is the recent surge of interest in this relatively unexplored field.

Should Society Allow Research Ethics Boards to Be Run As For-Profit Enterprises?

PubMed Central

Emanuel, Ezekiel J; Lemmens, Trudo; Elliot, Carl

2006-01-01

Background to the debate: An important mechanism for protecting human research participants is the prior approval of a clinical study by a research ethics board, known in the United States as an institutional review board (IRB). Traditionally, IRBs have been run by volunteer committees of scientists and clinicians working in the academic medical centers where the studies they review are being carried out. However, for-profit organizations are increasingly being hired to conduct ethics reviews. Proponents of for-profit IRBs argue that these IRBs are just as capable as academic IRBs at providing high-quality ethics reviews. Critics argue that for-profit IRBs have a conflict of interest because they generate their income from clients who have a direct financial interest in obtaining approval. PMID:16848618

Radiometals (non-Tc, non-Re) and Bifunctional Labeling Chemistry

NASA Astrophysics Data System (ADS)

Fani, M.; Good, S.; Maecke, H. R.

Radiometals are of increased current interest because of the growing use of targeted radiotherapy for tumors and the development of generators that produce positron-emitting radiometals. In addition, biomedical cyclotrons allow the cheap production of some relevant radiometals. The design of the corresponding radiopharmaceuticals includes the synthesis of bifunctional chelators, which carry a functional unit for the immobilization of the radiometal and a functional group for the covalent attachment to a vector molecule. Radiometals of interest for therapeutic applications are some lanthanides, 67Cu, and 90Y. For diagnostic applications 61Cu, 62Cu, 64Cu, 89Zr, and 68Ga are currently used and corresponding radiopharmaceuticals are being designed. In this chapter, some properties and the synthesis of bifunctional chelators including metal ion selectivity and special aspects of coupling chemistry are being described.

Automated AFM for small-scale and large-scale surface profiling in CMP applications

NASA Astrophysics Data System (ADS)

Zandiatashbar, Ardavan; Kim, Byong; Yoo, Young-kook; Lee, Keibock; Jo, Ahjin; Lee, Ju Suk; Cho, Sang-Joon; Park, Sang-il

2018-03-01

As the feature size is shrinking in the foundries, the need for inline high resolution surface profiling with versatile capabilities is increasing. One of the important areas of this need is chemical mechanical planarization (CMP) process. We introduce a new generation of atomic force profiler (AFP) using decoupled scanners design. The system is capable of providing small-scale profiling using XY scanner and large-scale profiling using sliding stage. Decoupled scanners design enables enhanced vision which helps minimizing the positioning error for locations of interest in case of highly polished dies. Non-Contact mode imaging is another feature of interest in this system which is used for surface roughness measurement, automatic defect review, and deep trench measurement. Examples of the measurements performed using the atomic force profiler are demonstrated.

"Women in Astronomy: an Essay Review"

NASA Astrophysics Data System (ADS)

Cox, M.

2006-12-01

Interest in the history of women in astronomy has increased dramatically in the last 30 years. This interest has come from the growing number of professional scientists, historians and feminists researching the lives and work of earlier generations, as well as from amateur astronomers. It is reflected in the vast amount of literature on the subject, both in books and journals, and on the internet. This Essay Review will focus on monographs published in the last 10 years (1996-2006), and will be restricted mainly to pre-20th century women. The scope includes researchers, translators, computers and astronomical assistants as well as observers. Where appropriate, it includes books that discuss the role of women scientists, as well as pure astronomy books. Part 2, to be published later, will consider encyclopaedias and large works of reference .

Leading Generative Groups: A Conceptual Model

ERIC Educational Resources Information Center

London, Manuel; Sobel-Lojeski, Karen A.; Reilly, Richard R.

2012-01-01

This article presents a conceptual model of leadership in generative groups. Generative groups have diverse team members who are expected to develop innovative solutions to complex, unstructured problems. The challenge for leaders of generative groups is to balance (a) establishing shared goals with recognizing members' vested interests, (b)…

Epigenetics and Future Generations.

PubMed

Del Savio, Lorenzo; Loi, Michele; Stupka, Elia

2015-10-01

Recent evidence of intergenerational epigenetic programming of disease risk broadens the scope of public health preventive interventions to future generations, i.e. non existing people. Due to the transmission of epigenetic predispositions, lifestyles such as smoking or unhealthy diet might affect the health of populations across several generations. While public policy for the health of future generations can be justified through impersonal considerations, such as maximizing aggregate well-being, in this article we explore whether there are rights-based obligations supervening on intergenerational epigenetic programming despite the non-identity argument, which challenges this rationale in case of policies that affect the number and identity of future people. We propose that rights based obligations grounded in the interests of non-existing people might fall upon existing people when generations overlap. In particular, if environmental exposure in F0 (i.e. existing people) will affect the health of F2 (i.e. non-existing people) through epigenetic programming, then F1 (i.e. existing and overlapping with both F0 and F2) might face increased costs to address F2's condition in the future: this might generate obligations upon F0 from various distributive principles, such as the principle of equal opportunity for well being. © 2015 John Wiley & Sons Ltd.

A Randomized Phase 2 Trial of 177Lu Radiolabeled Anti-PSMA Monoclonal Antibody J591 in Patients with High-Risk Castrate, Biochemically Relapsed Prostate Cancer

DTIC Science & Technology

2014-09-01

antibody (J591) against the external portion of PSMA that binds to viable PSMA-expressing cells and is internalized. Studies utilizing J591...metastatic CRPC to bone (Rad223, Xofigo ®) leading to excitement within the field. A more tumor-targeted approach utilizing J591 is of increased...has generated renewed scientific and clinical interest. In addition, recent studies utilizing J591-based immuno- PET imaging providing additional

Games for Training: Leveraging Commercial Off the Shelf Multiplayer Gaming Software for Infantry Squad Collective Training

DTIC Science & Technology

2005-09-01

squad training, team training, dismounted training, video games , computer games, multiplayer games. 16. PRICE CODE 17. SECURITY CLASSIFICATION OF...Multiplayer - mode of play for computer and video games in which multiple people can play the same game at the same time (Wikipedia, 2005) D...that “improvements in 3-D image generation on the PC and the speed of the internet” have increased the military’s interest in the use of video games as

Implementing Legacy-C Algorithms in FPGA Co-Processors for Performance Accelerated Smart Payloads

NASA Technical Reports Server (NTRS)

Pingree, Paula J.; Scharenbroich, Lucas J.; Werne, Thomas A.; Hartzell, Christine

2008-01-01

Accurate, on-board classification of instrument data is used to increase science return by autonomously identifying regions of interest for priority transmission or generating summary products to conserve transmission bandwidth. Due to on-board processing constraints, such classification has been limited to using the simplest functions on a small subset of the full instrument data. FPGA co-processor designs for SVM1 classifiers will lead to significant improvement in on-board classification capability and accuracy.

Microfluidics for Drug Discovery and Development: From Target Selection to Product Lifecycle Management

PubMed Central

Kang, Lifeng; Chung, Bong Geun; Langer, Robert; Khademhosseini, Ali

2009-01-01

Microfluidic technologies’ ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristics make microfluidic systems a potentially valuable tool for many drug discovery and development applications. Here, we review the recent advances of microfluidic devices for drug discovery and development and highlight their applications in different stages of the process, including target selection, lead identification, preclinical tests, clinical trials, chemical synthesis, formulations studies, and product management. PMID:18190858

Design of a Maximum Power Point Tracker with Simulation, Analysis, and Comparison of Algorithms

DTIC Science & Technology

2012-12-01

BLANK xxvi CHAPTER 1: INTRODUCTION It is a warm summer day. You feel the sun warm your skin and rejuvenate your motiva- tion. The sun generates more... renewable , there has been an upsurge of interest in clean and renewable energy. While more than one option is available to fill that void, the most...solar array. When this algorithm is functioning correctly, it is said to be an MPPT . 1.2 Motivation Clean and renewable energy has greatly increased

Propagation of Obesity Across Generations: The Roles of Differential Realized Fertility and Assortative Mating by Body Mass Index

PubMed Central

Dawson, John A.; Dhurandhar, Emily J.; Vazquez, Ana I.; Peng, Bo; Allison, David B.

2013-01-01

Background/Aims To quantify the extent to which the increase in obesity observed across recent generations of the American population is associated with the individual or combined effects of assortative mating for body mass index (BMI; kg/m2) and differential realized fertility by BMI. Methods A Monte Carlo framework is formed and informed using data collected from the National Longitudinal Survey of Youth (NLSY). The model has two portions, one that generates childbirth events on an annual basis and another that produces a BMI for each child. Once the model is informed using the data, a reference distribution of offspring BMIs is simulated. We quantify the effects of our factors of interest by removing them from the model and comparing the resulting offspring BMI distributions with that of the baseline scenario. Results An association between maternal BMI and number of offspring is evidenced in the NLSY data, as well as the presence of assortative mating. These two factors combined are associated with increased mean BMI (+0.067, C.I. [0.056, 0.078]), increased BMI variance (+0.578, C.I. [0.418, 0.736]) and increased prevalence of obesity (RR 1.032, 95% C.I. [1.023, 1.041]) and BMIs over 40 (RR 1.083, 95% C.I. [1.053, 1.118]) among offspring. Conclusion Our investigation suggests that both differential realized fertility and assortative mating by BMI appear to play a role in the increasing prevalence of obesity in America. PMID:24081235

CH3NH3I post-treatment improves the performance of perovskite solar cells via eliminating the impure phases

NASA Astrophysics Data System (ADS)

Liang, Jingjing; Liang, Chunjun; Zhang, Huimin; Sun, Mengjie; Liu, Hong; Ji, Chao; Zhang, Xuewen; Li, Dan; He, Zhiqun

Organic-inorganic halide perovskites are currently generating extensive interest for applications in solar cells. The perovskite morphology and composition have significant roles in solar cells. Impure phases, which will influence the performance of solar cells, are inevitably present in the film of perovskite. We found that another MAI deposition on the previous perovskite could ameliorate the film. The post-deposited MAI participates in the reconstruction of the perovskite, leading to reduced amount of impure phase, increased grain size, increased absorption and significantly improved power conversion efficiency. The results demonstrate a treatment approach to fabricate efficient planar heterojunction perovskite solar cells.

Synthesis, Structure, and Properties of Refractory Hard-Metal Borides

NASA Astrophysics Data System (ADS)

Lech, Andrew Thomas

As the limits of what can be achieved with conventional hard compounds, such as tungsten carbide, are nearing reach, super-hard materials are an area of increasing industrial interest. The refractory hard metal borides, such as ReB2 and WB4, offer an increasingly attractive alternative to diamond and cubic boron nitride as a next-generation tool material. In this Thesis, a thorough discussion is made of the progress achieved by our laboratory towards understanding the synthesis, structure, and properties of these extremely hard compounds. Particular emphasis is placed on structural manipulation, solid solution formation, and the unique crystallographic manifestations of what might also be called "super-hard metals".

Prediction of Interests from Values: A Longitudinal Investigation.

ERIC Educational Resources Information Center

Mason, Avonne; And Others

Interest in the attitude-behavior relationship has generated much research since the concept was introduced into research in 1934. This study examined the relationship between values and behavioral intentions, specifically in regard to interest in entering a particular medical specialization. Using structural equation techniques and a longitudinal…

Next-Generation Performance-Based Regulation: Emphasizing Utility Performance to Unleash Power Sector Innovation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Logan, Jeffrey S; Zinaman, Owen R; Littell, David

Performance-based regulation (PBR) enables regulators to reform hundred-year-old regulatory structures to unleash innovations within 21st century power systems. An old regulatory paradigm built to ensure safe and reliable electricity at reasonable prices from capital-intensive electricity monopolies is now adjusting to a new century of disruptive technological advances that change the way utilities make money and what value customers expect from their own electricity company. Advanced technologies are driving change in power sectors around the globe. Innovative technologies are transforming the way electricity is generated, delivered, and consumed. These emerging technology drivers include renewable generation, distributed energy resources such as distributedmore » generation and energy storage, demand-side management measures such as demand-response, electric vehicles, and smart grid technologies and energy efficiency (EE). PBR enables regulators to recognize the value that electric utilities bring to customers by enabling these advanced technologies and integrating smart solutions into the utility grid and utility operations. These changes in the electric energy system and customer capacities means that there is an increasing interest in motivating regulated entities in other areas beyond traditional cost-of-service performance regulation. This report addresses best practices gleaned from more than two decades of PBR in practice, and analyzes how those best practices and lessons can be used to design innovative PBR programs. Readers looking for an introduction to PBR may want to focus on Chapters 1-5. Chapters 6 and 7 contain more detail for those interested in the intricate workings of PBR or particularly innovative PBR.« less

Physics in Context--A Means to Encourage Student Interest in Physics

ERIC Educational Resources Information Center

Waltner, Christine; Wiesner, Hartmut; Rachel, Alexander

2007-01-01

Physics instruction that is student oriented will generate a long-term individual interest and therefore a lifelong openness to science. Phenomena of nature are part of the fields of interest which provide context leading to greater student interest. In this paper we present the locomotion of fish and sperm in a way which can be used to teach in…

Dazed and confused: sports medicine, conflicts of interest, and concussion management.

PubMed

Partridge, Brad

2014-03-01

Professional sports with high rates of concussion have become increasingly concerned about the long-term effects of multiple head injuries. In this context, return-to-play decisions about concussion generate considerable ethical tensions for sports physicians. Team doctors clearly have an obligation to the welfare of their patient (the injured athlete) but they also have an obligation to their employer (the team), whose primary interest is typically success through winning. At times, a team's interest in winning may not accord with the welfare of an injured player, particularly when it comes to decisions about returning to play after injury. Australia's two most popular professional football codes-rugby league and Australian Rules football-have adopted guidelines that prohibit concussed players from continuing to play on the same day. I suggest that conflicts of interest between doctors, patients, and teams may present a substantial obstacle to the proper adherence of concussion guidelines. Concussion management guidelines implemented by a sport's governing body do not necessarily remove or resolve conflicts of interest in the doctor-patient-team triad. The instigation of a concussion exclusion rule appears to add a fourth party to this triad (the National Rugby League or the Australian Football League). In some instances, when conflicts of interest among stakeholders are ignored or insufficiently managed, they may facilitate attempts at circumventing concussion management guidelines to the detriment of player welfare.

Aerodynamic beam generator for large particles

DOEpatents

Brockmann, John E.; Torczynski, John R.; Dykhuizen, Ronald C.; Neiser, Richard A.; Smith, Mark F.

2002-01-01

A new type of aerodynamic particle beam generator is disclosed. This generator produces a tightly focused beam of large material particles at velocities ranging from a few feet per second to supersonic speeds, depending on the exact configuration and operating conditions. Such generators are of particular interest for use in additive fabrication techniques.

Exploring the Development of College Students' Situational Interest in Learning Science

ERIC Educational Resources Information Center

Lin, Huann-shyang; Hong, Zuway-R; Chen, Ya-Chun

2013-01-01

This quasi-experimental study explores how student cumulative situational interest, short-term preference generated by particular conditions such as novel experiences can be developed into better individual interest, an enduring predisposition to engage in certain activity such as chemistry lessons. A continuous intervention of integrating novelty…

Interest, Inferences, and Learning from Texts

ERIC Educational Resources Information Center

Clinton, Virginia; van den Broek, Paul

2012-01-01

Topic interest and learning from texts have been found to be positively associated with each other. However, the reason for this positive association is not well understood. The purpose of this study is to examine a cognitive process, inference generation, that could explain the positive association between interest and learning from texts. In…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoke, Anderson; Shirazi, Mariko; Chakraborty, Sudipta

As deployment of power electronic coupled generation such as photovoltaic (PV) systems increases, grid operators have shown increasing interest in calling on inverter-coupled generation to help mitigate frequency contingency events by rapidly surging active power into the grid. When responding to contingency events, the faster the active power is provided, the more effective it may be for arresting the frequency event. This paper proposes a predictive PV inverter control method for very fast and accurate control of active power. This rapid active power control method will increase the effectiveness of various higher-level controls designed to mitigate grid frequency contingency events,more » including fast power-frequency droop, inertia emulation, and fast frequency response, without the need for energy storage. The rapid active power control method, coupled with a maximum power point estimation method, is implemented in a prototype PV inverter connected to a PV array. The prototype inverter's response to various frequency events is experimentally confirmed to be fast (beginning within 2 line cycles and completing within 4.5 line cycles of a severe test event) and accurate (below 2% steady-state error).« less

The potential use of genetics to increase the effectiveness of treatment programs for criminal offenders.

PubMed

Beaver, Kevin M; Jackson, Dylan B; Flesher, Dillon

2014-01-01

During the past couple of decades, the amount of research examining the genetic underpinnings to antisocial behaviors, including crime, has exploded. Findings from this body of work have generated a great deal of information linking genetics to criminal involvement. As a partial result, there is now a considerable amount of interest in how these findings should be integrated into the criminal justice system. In the current paper, we outline the potential ways that genetic information can be used to increase the effectiveness of treatment programs designed to reduce recidivism among offenders. We conclude by drawing attention to how genetic information can be used by rehabilitation programs to increase program effectiveness, reduce offender recidivism rates, and enhance public safety.

Using a Non-Equivalent Groups Quasi Experimental Design to Reduce Internal Validity Threats to Claims Made by Math and Science K-12 Teacher Recruitment Programs

NASA Astrophysics Data System (ADS)

Moin, Laura

2009-10-01

The American Recovery and Reinvestment Act national policy established in 2009 calls for ``meaningful data'' that demonstrate educational improvements, including the recruitment of high-quality teachers. The scant data available and the low credibility of many K-12 math/science teacher recruitment program evaluations remain the major barriers for the identification of effective recruitment strategies. Our study presents a methodology to better evaluate the impact of recruitment programs on increasing participants' interest in teaching careers. The research capitalizes on the use of several control groups and presents a non-equivalent groups quasi-experimental evaluation design that produces program effect claims with higher internal validity than claims generated by current program evaluations. With this method that compares responses to a teaching career interest question from undergraduates all along a continuum from just attending an information session to participating (or not) in the recruitment program, we were able to compare the effect of the program in increasing participants' interest in teaching careers versus the evolution of the same interest but in the absence of the program. We were also able to make suggestions for program improvement and further research. While our findings may not apply to other K-12 math/science teacher recruitment programs, we believe that our evaluation methodology does and will contribute to conduct stronger program evaluations. In so doing, our evaluation procedure may inform recruitment program designers and policy makers.

Nitroxyl (HNO) Releasing Therapeutics | NCI Technology Transfer Center | TTC

Cancer.gov

The National Cancer Institute's Cancer and Inflammation Program is seeking statements of capability or interest from parties interested in licensing therapeutic agents that generate Nitroxyl (HNO) in physiological media.

Exercise activates compensatory thermoregulatory reaction in rats: a modeling study

PubMed Central

Yoo, Yeonjoo; LaPradd, Michelle; Kline, Hannah; Zaretskaia, Maria V.; Behrouzvaziri, Abolhassan; Rusyniak, Daniel E.; Molkov, Yaroslav I.

2015-01-01

The importance of exercise is increasingly emphasized for maintaining health. However, exercise itself can pose threats to health such as the development of exertional heat shock in warm environments. Therefore, it is important to understand how the thermoregulation system adjusts during exercise and how alterations of this can contribute to heat stroke. To explore this we measured the core body temperature of rats (Tc) running for 15 min on a treadmill at various speeds in two ambient temperatures (Ta = 25°C and 32°C). We assimilated the experimental data into a mathematical model that describes temperature changes in two compartments of the body, representing the muscles and the core. In our model the core body generates heat to maintain normal body temperature, and dissipates it into the environment. The muscles produce additional heat during exercise. According to the estimation of model parameters, at Ta = 25°C, the heat generation in the core was progressively reduced with the increase of the treadmill speed to compensate for a progressive increase in heat production by the muscles. This compensation was ineffective at Ta = 32°C, which resulted in an increased rate of heat accumulation with increasing speed, as opposed to the Ta = 25°C case. Interestingly, placing an animal on a treadmill increased heat production in the muscles even when the treadmill speed was zero. Quantitatively, this “ready-to-run” phenomenon accounted for over half of the heat generation in the muscles observed at maximal treadmill speed. We speculate that this anticipatory response utilizes stress-related circuitry. PMID:26472864

A PLL-based resampling technique for vibration analysis in variable-speed wind turbines with PMSG: A bearing fault case

NASA Astrophysics Data System (ADS)

Pezzani, Carlos M.; Bossio, José M.; Castellino, Ariel M.; Bossio, Guillermo R.; De Angelo, Cristian H.

2017-02-01

Condition monitoring in permanent magnet synchronous machines has gained interest due to the increasing use in applications such as electric traction and power generation. Particularly in wind power generation, non-invasive condition monitoring techniques are of great importance. Usually, in such applications the access to the generator is complex and costly, while unexpected breakdowns results in high repair costs. This paper presents a technique which allows using vibration analysis for bearing fault detection in permanent magnet synchronous generators used in wind turbines. Given that in wind power applications the generator rotational speed may vary during normal operation, it is necessary to use special sampling techniques to apply spectral analysis of mechanical vibrations. In this work, a resampling technique based on order tracking without measuring the rotor position is proposed. To synchronize sampling with rotor position, an estimation of the rotor position obtained from the angle of the voltage vector is proposed. This angle is obtained from a phase-locked loop synchronized with the generator voltages. The proposed strategy is validated by laboratory experimental results obtained from a permanent magnet synchronous generator. Results with single point defects in the outer race of a bearing under variable speed and load conditions are presented.

New transmission planning methodology for requesting proposals for wind generation

NASA Astrophysics Data System (ADS)

Isaacs, Andrew L.

The increasing interest in renewable energy technologies during the last decade has caused conventional transmission and generation expansion planning methodologies to be strained and in some cases abandoned. This is due both to the quantity of generator interconnection requests and the constraints imposed by deregulated energy industry structures. One technique used to control the influx of renewable generation while maintaining competitive principles is a Request for Proposals (RFP). However, lack of transmission planning due to a disconnection between generation and transmission owners, difficulty in identifying viable projects, and high risk for proponents stand as obstacles to the goals of an RFP. This research proposes a procedure which minimizes the effect of these obstacles; meeting the purchaser requirements for low price and combining conventional planning concepts with feedback from competitive structures. The general features of the method include definition of generation limits and study area, expansion plan design, transmission cost evaluation, optimal selection of requested generation levels, and final selection of successful proponents. The method is shown to be effective in creating an RFP where proponents are well-informed and provided with cost certainty to reduce bid price, buyers are able to determine end costs of their energy, and good expansion planning principles are maintained. A case study using a real system in New Mexico demonstrates these concepts.

Solution-Grown Rubrene Crystals as Radiation Detecting Devices

DOE PAGES

Carman, Leslie; Martinez, H. Paul; Voss, Lars; ...

2017-01-11

There has been increased interest in organic semiconductors over the last decade because of their unique properties. Of these, 5, 6, 11, 12-tetraphenylnaphthacene (rubrene) has generated the most interest because of its high charge carrier mobility. In this paper, large single crystals with a volume of ~1 cm 3 were grown from solution by a temperature reduction technique. The faceted crystals had flat surfaces and cm-scale, visually defect-free areas suitable for physical characterization. X-ray diffraction analysis indicates that solvent does not incorporate into the crystals and photoluminescence spectra are consistent with pristine, high-crystallinity rubrene. Furthermore, the response curve to pulsedmore » optical illumination indicates that the solution grown crystals are of similar quality to those grown by physical vapor transport, albeit larger. The good quality of these crystals in combination with the improvement of electrical contacts by application of conductive polymer on the graphite electrodes have led to the clear observation of alpha particles with these rubrene detectors. Finally, preliminary results with a 252Cf source generate a small signal with the rubrene detector and may demonstrate that rubrene can also be used for detecting high-energy neutrons.« less

Prognostic alternative mRNA splicing signature in non-small cell lung cancer.

PubMed

Li, Yuan; Sun, Nan; Lu, Zhiliang; Sun, Shouguo; Huang, Jianbing; Chen, Zhaoli; He, Jie

2017-05-01

Alternative splicing provides a major mechanism to generate protein diversity. Increasing evidence suggests a link of dysregulation of splicing associated with cancer. Genome-wide alternative splicing profiling in lung cancer remains largely unstudied. We generated alternative splicing profiles in 491 lung adenocarcinoma (LUAD) and 471 lung squamous cell carcinoma (LUSC) patients in TCGA using RNA-seq data, prognostic models and splicing networks were built by integrated bioinformatics analysis. A total of 3691 and 2403 alternative splicing events were significantly associated with patient survival in LUAD and LUSC, respectively, including EGFR, CD44, PIK3C3, RRAS2, MAPKAP1 and FGFR2. The area under the curve of the receiver-operator characteristic curve for prognostic predictor in NSCLC was 0.817 at 2000 days of overall survival which were also over 0.8 in LUAD and LUSC, separately. Interestingly, splicing correlation networks uncovered opposite roles of splicing factors in LUAD and LUSC. We created prognostic predictors based on alternative splicing events with high performances for risk stratification in NSCLC patients and uncovered interesting splicing networks in LUAD and LUSC which could be underlying mechanisms. Copyright © 2017 Elsevier B.V. All rights reserved.

Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review.

PubMed

Bhargava, Seema; Tyagi, S C

2014-02-01

Although normally folic acid is given during pregnancy, presumably to prevent neural tube defects, the mechanisms of this protection are unknown. More importantly it is unclear whether folic acid has other function during development. It is known that folic acid re-methylates homocysteine (Hcy) to methionine by methylene tetrahydrofolate reductase-dependent pathways. Folic acid also generates high-energy phosphates, behaves as an antioxidant and improves nitric oxide (NO) production by endothelial NO synthase. Interestingly, during epigenetic modification, methylation of DNA/RNA generate homocysteine unequivocally. The enhanced overexpression of methyl transferase lead to increased yield of Hcy. The accumulation of Hcy causes vascular dysfunction, reduces perfusion in the muscles thereby causing musculopathy. Another interesting fact is that children with severe hyperhomocysteinaemia (HHcy) have skeletal deformities, and do not live past teenage. HHcy is also associated with the progeria syndrome. Epilepsy is primarily caused by inhibition of gamma-amino-butyric-acid (GABA) receptor, an inhibitory neurotransmitter in the neuronal synapse. Folate deficiency leads to HHcy which then competes with GABA for binding on the GABA receptors. With so many genetic and clinical manifestations associated with folate deficiency, we propose that folate deficiency induces epigenetic alterations in the genes and thereby results in disease.

Generating Accurate Urban Area Maps from Nighttime Satellite (DMSP/OLS) Data

NASA Technical Reports Server (NTRS)

Imhoff, Marc; Lawrence, William; Elvidge, Christopher

2000-01-01

There has been an increasing interest by the international research community to use the nighttime acquired "city-lights" data sets collected by the US Defense Meteorological Satellite Program's Operational Linescan system to study issues relative to urbanization. Many researchers are interested in using these data to estimate human demographic parameters over large areas and then characterize the interactions between urban development , natural ecosystems, and other aspects of the human enterprise. Many of these attempts rely on an ability to accurately identify urbanized area. However, beyond the simple determination of the loci of human activity, using these data to generate accurate estimates of urbanized area can be problematic. Sensor blooming and registration error can cause large overestimates of urban land based on a simple measure of lit area from the raw data. We discuss these issues, show results of an attempt to do a historical urban growth model in Egypt, and then describe a few basic processing techniques that use geo-spatial analysis to threshold the DMSP data to accurately estimate urbanized areas. Algorithm results are shown for the United States and an application to use the data to estimate the impact of urban sprawl on sustainable agriculture in the US and China is described.

[Ethical use of antibiotics in the era of multiresistance: a common good for the individual or the society?].

PubMed

Mazzon, Davide

2016-02-01

Common goods refer to goods that may be used by anyone belonging to the community that has use rights over a commons and are fundamental to people's lives. Appropriate measures for safeguarding common goods should be undertaken, also for the benefit of future generations. Drugs in general, and antibiotics in particular, should be considered a common good as well. However, antibiotic use confined to the individual health benefit not only leads to less favorable outcomes for the society but also results in the development of antimicrobial resistance in the individual patient. This phenomenon is termed "tragedy of the commons" and identifies the impossibility of achieving over time the optimal treatment for each individual subject/patient. As a consequence, pursuing individual interests may lead to societal detriment. Conversely, restricting antibiotic prescriptions (e.g., avoiding overuse or misuse of last-generation antibiotics for the treatment of an infection) is not harmful for the individual, would benefit society with increased efficacy, and does not favor the emergence of antibiotic resistance. In this editorial, several suggestions as to how antibiotics should be appropriately used are provided in accordance with distributive justice principles, where individual and social interests meet.

Stimulus waveform determines the characteristics of sensory nerve action potentials.

PubMed

Pereira, Pedro; Leote, João; Cabib, Christopher; Casanova-Molla, Jordi; Valls-Sole, Josep

2016-03-01

In routine nerve conduction studies supramaximal electrical stimuli generate sensory nerve action potentials by depolarization of nerve fibers under the cathode. However, stimuli of submaximal intensity may give rise to action potentials generated under the anode. We tested if this phenomenon depends on the characteristics of stimulus ending. We added a circuit to our stimulation device that allowed us to modify the end of the stimulus by increasing the time constant of the decay phase. Increasing the fall time caused a reduction of anode action potential (anAP) amplitude, and eventually abolished it, in all tested subjects. We subsequently examined the stimulus waveform in a series of available electromyographs stimulators and found that the anAP could only be obtained with stimulators that issued stimuli ending sharply. Our results prove that the anAP is generated at stimulus end, and depends on the sharpness of current shut down. Electromyographs produce stimuli of varying characteristics, which limits the reproducibility of anAP results by interested researchers. The study of anodal action potentials might be a useful tool to have a quick appraisal of distal human sensory nerve excitability. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

2d axisymmetric "beam-bulk" modelling of the generation of runaway electrons by streamers.

NASA Astrophysics Data System (ADS)

Chanrion, Olivier; Bonaventura, Zdenek; Bourdon, Anne; Neubert, Torsten

2017-04-01

We present results from a 2d axisymmetric numerical model of streamers based on a "beam-bulk" approach which describes cold electrons with a fluid model and high energy electrons with a particle model. The interest is motivated by the generation of runaway electrons by streamers which may participate in the recently observed TGFs and which challenge the modelling. Runaway electrons are known to be generated from streamers when the electric field in its negative tip is of sufficient magnitude. After overtaking the streamer tip, runaways can affect the streamer propagation ahead and may produce high energy photons through the bremsstrahlung process. In conventional model of streamers, the evolution of the streamer discharge is mostly governed by cold electrons. By including runaway electrons, we model their production, their impact on the discharge propagation and can address their role in TGFs. Results of streamer propagation in leader electric field show that the runaway electrons accelerate the streamers, reduce the electric field in its tip and enlarge its radius by pre-ionizing the gas ahead. We observed that if we increase the electric field, the discharge is getting more diffuse, with a pattern driven by the increase in runaway induced ionisation.

Analysis and Visualization of ChIP-Seq and RNA-Seq Sequence Alignments Using ngs.plot.

PubMed

Loh, Yong-Hwee Eddie; Shen, Li

2016-01-01

The continual maturation and increasing applications of next-generation sequencing technology in scientific research have yielded ever-increasing amounts of data that need to be effectively and efficiently analyzed and innovatively mined for new biological insights. We have developed ngs.plot-a quick and easy-to-use bioinformatics tool that performs visualizations of the spatial relationships between sequencing alignment enrichment and specific genomic features or regions. More importantly, ngs.plot is customizable beyond the use of standard genomic feature databases to allow the analysis and visualization of user-specified regions of interest generated by the user's own hypotheses. In this protocol, we demonstrate and explain the use of ngs.plot using command line executions, as well as a web-based workflow on the Galaxy framework. We replicate the underlying commands used in the analysis of a true biological dataset that we had reported and published earlier and demonstrate how ngs.plot can easily generate publication-ready figures. With ngs.plot, users would be able to efficiently and innovatively mine their own datasets without having to be involved in the technical aspects of sequence coverage calculations and genomic databases.

Impacts of geothermal energy developments on hydrological environment in hot spring areas

NASA Astrophysics Data System (ADS)

Taniguchi, M.

2015-12-01

Water-energy nexus such as geothermal energy developments and its impacts on groundwater, river water, and coastal water is one of the key issues for the sustainable society. This is because the demand of both water and energy resources will be increasing in near future, and the tradeoff between both resources and conflict between stakeholders will be arisen. Geothermal power generation, hot springs heat power generation, and steam power generation, are developing in hot spring areas in Ring of Fire countries including Japan, as renewable and sustainable energy. Impacts of the wasted hot water after using hot springs heat and steam power generation on ecosystem in the rivers have been observed in Beppu, Oita prefecture, Japan. The number of the fish species with wasted hot water in the Hirata river is much less than that without wasted hot water in Hiyakawa river although the dominant species of tilapia was found in the Hirata river with wasted hot water. The water temperature in Hirata rive is increased by wasted hot water by 10 degree C. The impacts of the developments of steam power generations on hot spring water and groundwater in downstream are also evaluated in Beppu. The decreases in temperature and volume of the hot spring water and groundwater after the development are concerning. Stakeholder analysis related to hot spa and power generation business and others in Beppu showed common interests in community development among stakeholders and gaps in prerequisite knowledge and recognition of the geothermal resource in terms of economic/non-economic value and utilization as power generation/hot-spring. We screened stakeholders of four categories (hot spring resorts inhabitants, industries, supporters, environmentalists), and set up three communities consisting of 50 persons of the above categories. One remarkable result regarding the pros and cons of geothermal power in general terms was that the supporter count increased greatly while the neutralities count decreased greatly after deliberation, suggesting a response from providing scientific evidence on the issue.

Current interest in careers in surgery and cardiothoracic surgery from the millennial generation.

PubMed

Ghannam, Michael; Zhao, Lili; Reddy, Rishindra M

2014-01-01

Interest in cardiothoracic surgery (CTS) as a career has decreased over the past decade. Anecdotal evidence suggests that many surgeons develop an interest in CTS before medical school and even before college. This study evaluates the interest of high-school students at a magnet high school, with regard to careers in medicine, in surgery, and in CTS. A survey assessing career interests and values was conducted among junior and senior high-school students. Students were given a 1-hour presentation by a cardiothoracic (CT) surgeon on the postgraduate training process and then completed a postpresentation survey. A magnet math and science high school, the Kalamazoo Area Mathematics and Science Center. Of 128 students, 117 (91% response rate) completed the survey. Overall, 38% of students reported having a high interest in medicine; of this group, 58% reported a high interest in surgery and 36% reported having a high interest in CTS. Men were more likely than women were to have a high interest in surgery and CTS (p < 0.001). Students with at least 1 family member as a physician vs those without were more likely to be interested in medicine, surgery, and CTS and also have a higher level of concern for postgraduation debt (p < 0.01). Women were more likely than men were to have a high level of concern about postgraduation debt (p = 0.018). After a presentation by a CT surgeon, students showed no changes in interest in medicine careers but did report an increased level of knowledge about the process of becoming a CT surgeon, going from 31% to 72%. There exists a large interest in both surgery and CTS at the high-school level, but there may be a need for more active outreach to maintain and foster their interest in surgery and CTS through undergraduate and medical school. Copyright © 2014 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Influence of bedrock topography on the runoff generation under use of ERT data

NASA Astrophysics Data System (ADS)

Kiese, Nina; Loritz, Ralf; Allroggen, Niklas; Zehe, Erwin

2017-04-01

Subsurface topography has been identified to play a major role for the runoff generation in different hydrological landscapes. Sinks and ridges in the bedrock can control how water is stored and transported to the stream. Detecting the subsurface structure is difficult and laborious and frequently done by auger measurements. Recently, the geophysical imaging of the subsurface by Electrical Resistivity Tomography (ERT) gained much interest in the field of hydrology, as it is a non-invasive method to collect information on the subsurface characteristics and particularly bedrock topography. As it is impossible to characterize the subsurface of an entire hydrological landscape using ERT, it is of key interest to identify the bedrock characteristics which dominate runoff generation to adapt and optimize the sampling design to the question of interest. For this study, we used 2D ERT images and auger measurements, collected on different sites in the Attert basin in Luxembourg, to characterize bedrock topography using geostatistics and shed light on those aspects which dominate runoff generation. Based on ERT images, we generated stochastic bedrock topographies and implemented them in a physically-based 2D hillslope model. With this approach, we were able to test the influence of different subsurface structures on the runoff generation. Our results highlight that ERT images can be useful for hydrological modelling. Especially the connection from the hillslope to the stream could be identified as important feature in the subsurface for the runoff generation whereas the microtopography of the bedrock seemed to be less relevant.

Reviewing the Need for Gaming in Education to Accommodate the Net Generation

ERIC Educational Resources Information Center

Bekebrede, G.; Warmelink, H. J. G.; Mayer, I. S.

2011-01-01

There is a growing interest in the use of simulations and games in Dutch higher education. This development is based on the perception that students belong to the "gamer generation" or "net generation": a generation that has grown up with computer games and other technology affecting their preferred learning styles, social…

Catalytic activity in lithium-treated core–shell MoO x/MoS 2 nanowires

DOE PAGES

Cummins, Dustin R.; Martinez, Ulises; Kappera, Rajesh; ...

2015-09-22

Significant interest has grown in the development of earth-abundant and efficient catalytic materials for hydrogen generation. Layered transition metal dichalcogenides present opportunities for efficient electrocatalytic systems. Here, we report the modification of 1D MoO x/MoS 2 core–shell nanostructures by lithium intercalation and the corresponding changes in morphology, structure, and mechanism of H 2 evolution. The 1D nanowires exhibit significant improvement in H 2 evolution properties after lithiation, reducing the hydrogen evolution reaction (HER) onset potential by ~50 mV and increasing the generated current density by ~600%. The high electrochemical activity in the nanowires results from disruption of MoS 2 layersmore » in the outer shell, leading to increased activity and concentration of defect sites. This is in contrast to the typical mechanism of improved catalysis following lithium exfoliation, i.e., crystal phase transformation. As a result, these structural changes are verified by a combination of Raman and X-ray photoelectron spectroscopy (XPS).« less

New approach to generating insights for aging research based on literature mining and knowledge integration

PubMed Central

Kwon, Yeondae; Natori, Yukikazu

2017-01-01

The proportion of the elderly population in most countries worldwide is increasing dramatically. Therefore, social interest in the fields of health, longevity, and anti-aging has been increasing as well. However, the basic research results obtained from a reductionist approach in biology and a bioinformatic approach in genome science have limited usefulness for generating insights on future health, longevity, and anti-aging-related research on a case by case basis. We propose a new approach that uses our literature mining technique and bioinformatics, which lead to a better perspective on research trends by providing an expanded knowledge base to work from. We demonstrate that our approach provides useful information that deepens insights on future trends which differs from data obtained conventionally, and this methodology is already paving the way for a new field in aging-related research based on literature mining. One compelling example of this is how our new approach can be a useful tool in drug repositioning. PMID:28817730

Biotechnological Trends in Spider and Scorpion Antivenom Development

PubMed Central

Laustsen, Andreas Hougaard; Solà, Mireia; Jappe, Emma Christine; Oscoz, Saioa; Lauridsen, Line Præst; Engmark, Mikael

2016-01-01

Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain. Information on venom composition and the toxins present in these species is growing due to an interest in using bioactive toxins from spiders and scorpions for drug discovery purposes and for solving crystal structures of membrane-embedded receptors. Additionally, the identification and isolation of a myriad of spider and scorpion toxins has allowed research within next generation antivenoms to progress at an increasingly faster pace. In this review, the current knowledge of spider and scorpion venoms is presented, followed by a discussion of all published biotechnological efforts within development of spider and scorpion antitoxins based on small molecules, antibodies and fragments thereof, and next generation immunization strategies. The increasing number of discovery and development efforts within this field may point towards an upcoming transition from serum-based antivenoms towards therapeutic solutions based on modern biotechnology. PMID:27455327

Hypoxia signaling controls postnatal changes in cardiac mitochondrial morphology and function

PubMed Central

Neary, Marianne T.; Ng, Keat-Eng; Ludtmann, Marthe H.R.; Hall, Andrew R.; Piotrowska, Izabela; Ong, Sang-Bing; Hausenloy, Derek J.; Mohun, Timothy J.; Abramov, Andrey Y.; Breckenridge, Ross A.

2014-01-01

Fetal cardiomyocyte adaptation to low levels of oxygen in utero is incompletely understood, and is of interest as hypoxia tolerance is lost after birth, leading to vulnerability of adult cardiomyocytes. It is known that cardiac mitochondrial morphology, number and function change significantly following birth, although the underlying molecular mechanisms and physiological stimuli are undefined. Here we show that the decrease in cardiomyocyte HIF-signaling in cardiomyocytes immediately after birth acts as a physiological switch driving mitochondrial fusion and increased postnatal mitochondrial biogenesis. We also investigated mechanisms of ATP generation in embryonic cardiac mitochondria. We found that embryonic cardiac cardiomyocytes rely on both glycolysis and the tricarboxylic acid cycle to generate ATP, and that the balance between these two metabolic pathways in the heart is controlled around birth by the reduction in HIF signaling. We therefore propose that the increase in ambient oxygen encountered by the neonate at birth acts as a key physiological stimulus to cardiac mitochondrial adaptation. PMID:24984146

Protein enrichment of brewery spent grain from Rhizopus oligosporus by solid-state fermentation.

PubMed

Canedo, Marianny Silva; de Paula, Fernanda Gomes; da Silva, Flávio Alves; Vendruscolo, Francielo

2016-07-01

Brewery spent grain represents approximately 85 % of total by-products generated in a brewery. Consisting of carbohydrates, fiber, minerals and low amounts of protein, the use of brewery spent grain is limited to the feeding of ruminants; however, its potential use should be investigated. The reuse of this by-product using microorganisms by solid-state fermentation process as the case of protein enrichment by single-cell protein incorporation is an alternative to ensure sustainability and generate commercially interesting products. In this context, the aim of this study was to grow Rhizopus oligosporus in brewery spent grain under different initial moisture contents and nitrogen sources to increase the protein content of the fermented material. After 7 days of fermentation, increase of 2-4 times in the crude protein and soluble protein content was verified, respectively, compared to unfermented brewery spent grain. The kinetics of protein enrichment demonstrated the possibility of application of this technique, which can be a great alternative for use in diets for animals.

Nanoscale thermal transport: Theoretical method and application

NASA Astrophysics Data System (ADS)

Zeng, Yu-Jia; Liu, Yue-Yang; Zhou, Wu-Xing; Chen, Ke-Qiu

2018-03-01

With the size reduction of nanoscale electronic devices, the heat generated by the unit area in integrated circuits will be increasing exponentially, and consequently the thermal management in these devices is a very important issue. In addition, the heat generated by the electronic devices mostly diffuses to the air in the form of waste heat, which makes the thermoelectric energy conversion also an important issue for nowadays. In recent years, the thermal transport properties in nanoscale systems have attracted increasing attention in both experiments and theoretical calculations. In this review, we will discuss various theoretical simulation methods for investigating thermal transport properties and take a glance at several interesting thermal transport phenomena in nanoscale systems. Our emphasizes will lie on the advantage and limitation of calculational method, and the application of nanoscale thermal transport and thermoelectric property. Project supported by the Nation Key Research and Development Program of China (Grant No. 2017YFB0701602) and the National Natural Science Foundation of China (Grant No. 11674092).

Development of deep-ultraviolet metal vapor lasers

NASA Astrophysics Data System (ADS)

Sabotinov, Nikola V.

2004-06-01

Deep ultraviolet laser generation is of great interest in connection with both the development of new industrial technologies and applications in medicine, biology, chemistry, etc. The development of metal vapor UV lasers oscillating in the pulsed mode with high pulse repetition frequencies and producing high average output powers is of particular interest for microprocessing of polymers, photolithography and fluorescence applications. At present, metal vapor lasers generate deep-UV radiation on the base of two methods. The first method is non-linear conversion of powerful laser generation from the visible region into the deep ultraviolet region. The second method is direct UV laser action on ion and atomic transitions of different metals.

Empirical investigation of a field theory formula and Black's formula for the price of an interest-rate caplet

NASA Astrophysics Data System (ADS)

Baaquie, Belal E.; Liang, Cui

2007-01-01

The industry standard for pricing an interest-rate caplet is Black's formula. Another distinct price of the same caplet can be derived using a quantum field theory model of the forward interest rates. An empirical study is carried out to compare the two caplet pricing formulae. Historical volatility and correlation of forward interest rates are used to generate the field theory caplet price; another approach is to fit a parametric formula for the effective volatility using market caplet price. The study shows that the field theory model generates the price of a caplet and cap fairly accurately. Black's formula for a caplet is compared with field theory pricing formula. It is seen that the field theory formula for caplet price has many advantages over Black's formula.

Caffeine, HPLC, Outreach (How Can We Interest Kids in Science?)

USDA-ARS?s Scientific Manuscript database

A current challenge for the scientific community is to generate an interest in science in the general public. If we can interest our youth in science we can produce more scientists and raise awareness of science in our society. An outreach activity will be described which can be brought into the cl...

Embedding the shapes of regions of interest into a Clinical Document Architecture document.

PubMed

Minh, Nguyen Hai; Yi, Byoung-Kee; Kim, Il Kon; Song, Joon Hyun; Binh, Pham Viet

2015-03-01

Sharing a medical image visually annotated by a region of interest with a remotely located specialist for consultation is a good practice. It may, however, require a special-purpose (and most likely expensive) system to send and view them, which is an unfeasible solution in developing countries such as Vietnam. In this study, we design and implement interoperable methods based on the HL7 Clinical Document Architecture and the eXtensible Markup Language Stylesheet Language for Transformation standards to seamlessly exchange and visually present the shapes of regions of interest using web browsers. We also propose a new integration architecture for a Clinical Document Architecture generator that enables embedding of regions of interest and simultaneous auto-generation of corresponding style sheets. Using the Clinical Document Architecture document and style sheet, a sender can transmit clinical documents and medical images together with coordinate values of regions of interest to recipients. Recipients can easily view the documents and display embedded regions of interest by rendering them in their web browser of choice. © The Author(s) 2014.

A framework for diversifying recommendation lists by user interest expansion.

PubMed

Zhang, Zhu; Zheng, Xiaolong; Zeng, Daniel Dajun

2016-08-01

Recommender systems have been widely used to discover users' preferences and recommend interesting items to users during this age of information load. Researchers in the field of recommender systems have realized that the quality of a top-N recommendation list involves not only relevance but also diversity. Most traditional recommendation algorithms are difficult to generate a diverse item list that can cover most of his/her interests for each user, since they mainly focus on predicting accurate items similar to the dominant interests of users. Additionally, they seldom exploit semantic information such as item tags and users' interest labels to improve recommendation diversity. In this paper, we propose a novel recommendation framework which mainly adopts an expansion strategy of user interests based on social tagging information. The framework enhances the diversity of users' preferences by expanding the sizes and categories of the original user-item interaction records, and then adopts traditional recommendation models to generate recommendation lists. Empirical evaluations on three real-world data sets show that our method can effectively improve the accuracy and diversity of item recommendation.

A framework for diversifying recommendation lists by user interest expansion

PubMed Central

Zhang, Zhu; Zeng, Daniel Dajun

2017-01-01

Recommender systems have been widely used to discover users’ preferences and recommend interesting items to users during this age of information load. Researchers in the field of recommender systems have realized that the quality of a top-N recommendation list involves not only relevance but also diversity. Most traditional recommendation algorithms are difficult to generate a diverse item list that can cover most of his/her interests for each user, since they mainly focus on predicting accurate items similar to the dominant interests of users. Additionally, they seldom exploit semantic information such as item tags and users’ interest labels to improve recommendation diversity. In this paper, we propose a novel recommendation framework which mainly adopts an expansion strategy of user interests based on social tagging information. The framework enhances the diversity of users’ preferences by expanding the sizes and categories of the original user-item interaction records, and then adopts traditional recommendation models to generate recommendation lists. Empirical evaluations on three real-world data sets show that our method can effectively improve the accuracy and diversity of item recommendation. PMID:28959089

Transition to an aging Japan: public pension, savings, and capital taxation.

PubMed

Kato, R

1998-09-01

This study examined options for compensating for the shortages of money for public pensions due to population aging in Japan: increases in pension contributions, consumption pension taxes, interest income pension taxes, and inheritance pension taxes. The analysis relied on simulation in an expanded life cycle growth model. Data were obtained from 1992 estimations of population by the Institute of Population Problems of the Ministry of Health and Welfare. This study is unique in its use of real population data for the simulations and in its use of transition states. The analysis begins with a description of the altered Overlapping Generations Model by Auerback and Kotlikoff (1983). The model accounts for the inaccuracy of lifetime and liquidity constraints and ordinary budget constraints and reproduces the consumption-savings profiles of older people and incorporates wage income taxation and other forms of taxation. Income includes wage and interest income. The analysis includes a description of the method of simulation, assumptions, and evaluation of the effects of population aging. It is assumed that narrower government sector spending on general expenditures per worker will increase by 1% every year. It is concluded that national saving rates will probably decrease due to population aging. The lowest levels of capital stock and savings will result from higher pension contributions. The highest level of capital stock will result from higher consumption pension taxes during 1990-2015. Preferred policies should focus on increasing interest income rates.

Indicators of science, technology, engineering, and math (STEM) career interest among middle school students in the USA

NASA Astrophysics Data System (ADS)

Mills, Leila A.

This study examines middle school students' perceptions of a future career in a science, math, engineering, or technology (STEM) career field. Gender, grade, predispositions to STEM contents, and learner dispositions are examined for changing perceptions and development in career-related choice behavior. Student perceptions as measured by validated measurement instruments are analyzed pre and post participation in a STEM intervention energy-monitoring program that was offered in several U.S. middle schools during the 2009-2010, 2010-2011 school years. A multiple linear regression (MLR) model, developed by incorporating predictors identified by an examination of the literature and a hypothesis-generating pilot study for prediction of STEM career interest, is introduced. Theories on the career choice development process from authors such as Ginzberg, Eccles, and Lent are examined as the basis for recognition of career concept development among students. Multiple linear regression statistics, correlation analysis, and analyses of means are used to examine student data from two separate program years. Study research questions focus on predictive ability, RSQ, of MLR models by gender/grade, and significance of model predictors in order to determine the most significant predictors of STEM career interest, and changes in students' perceptions pre and post program participation. Analysis revealed increases in the perceptions of a science career, decreases in perceptions of a STEM career, increase of the significance of science and mathematics to predictive models, and significant increases in students' perceptions of creative tendencies.

Method for measuring pollutant formation

NASA Technical Reports Server (NTRS)

Stickler, David B. (Inventor); Annen, Kurt (Inventor)

2001-01-01

Diagnostic methods for determining an instantaneous rate of pollutant formation in a combustion system are based on measurement of chemiluminescence intensity generated simultaneously with the formation of the pollutant. The chemiluminescent signal is generated by an analog reaction which occurs in parallel with a key step in the formation of a specific pollutant of interest. The connection between the analog reaction and the pollution reaction is such that the chemiluminescent signal indicates the local, instantaneous formation rate of the pollutant of interest.

Enhancing Dissemination, Implementation, and Improvement Science in CTSAs through Regional Partnerships.

PubMed

Inkelas, Moira; Brown, Arleen F; Vassar, Stefanie D; Sankaré, Ibrahima C; Martinez, Arturo B; Kubicek, Katrina; Kuo, Tony; Mahajan, Anish; Gould, Michael; Mittman, Brian S

2015-12-01

Challenges in healthcare policy and practice have stimulated interest in dissemination and implementation science. The Institute of Medicine Committee on the Clinical Translational Science Award (CTSA) program recommended expanding the CTSA program's investment and activity in this domain. Guidance is needed to facilitate successful growth of DII science infrastructure, activity and impacts. Several CTSAs in Southern California collaborated to identify and respond to local challenges and opportunities to expand dissemination, implementation and improvement research by strengthening capacity and relationships between DII researchers and community, health system, and population health partners. Planning and outreach by the Southern California CTSAs increased awareness and interest in DII research and generated recommendations for growth. Recommendations include: increasing strong partnerships with healthcare and population health systems to guide policy research agendas and collaborative DII science; promoting multi-sector partnerships that involve researchers and delivery systems throughout DII processes; bringing together multiple disciplines; and addressing national and international barriers as well as opportunities in DII science. CTSAs through regional collaboration can increase their contributions to improved community health via skill-building, partnership development and enhanced outreach to local healthcare and public health agencies and delivery systems. © 2015 Wiley Periodicals, Inc.

Enhancing Dissemination, Implementation, and Improvement Science in CTSAs through Regional Partnerships

PubMed Central

Brown, Arleen F.; Vassar, Stefanie D.; Sankaré, Ibrahima C.; Martinez, Arturo B.; Kubicek, Katrina; Kuo, Tony; Mahajan, Anish; Gould, Michael; Mittman, Brian S.

2015-01-01

Abstract Background and Importance Challenges in healthcare policy and practice have stimulated interest in dissemination and implementation science. The Institute of Medicine Committee on the Clinical Translational Science Award (CTSA) program recommended expanding the CTSA program's investment and activity in this domain. Guidance is needed to facilitate successful growth of DII science infrastructure, activity and impacts. Objectives Several CTSAs in Southern California collaborated to identify and respond to local challenges and opportunities to expand dissemination, implementation and improvement research by strengthening capacity and relationships between DII researchers and community, health system, and population health partners. Main outcomes Planning and outreach by the Southern California CTSAs increased awareness and interest in DII research and generated recommendations for growth. Recommendations include: increasing strong partnerships with healthcare and population health systems to guide policy research agendas and collaborative DII science; promoting multi‐sector partnerships that involve researchers and delivery systems throughout DII processes; bringing together multiple disciplines; and addressing national and international barriers as well as opportunities in DII science. Implications CTSAs through regional collaboration can increase their contributions to improved community health via skill‐building, partnership development and enhanced outreach to local healthcare and public health agencies and delivery systems. PMID:26602191

Antiobesity effects of resveratrol: which tissues are involved?

PubMed

Fernández-Quintela, Alfredo; Milton-Laskibar, Iñaki; González, Marcela; Portillo, Maria P

2017-09-01

The prevalence of obesity has been increasing in recent decades and is reaching epidemic proportions. The current options for overweight and obesity management are energy restriction and physical activity. However, compliance with these treatments is frequently poor and less successful than expected. Therefore, the scientific community is interested in active biomolecules, which may be useful in body weight management. Among them, resveratrol (3,5,4'-trihydroxy-trans-stilbene) has generated great interest as an antiobesity agent. The focus of this report is the mechanisms of action of resveratrol on several tissues (i.e., white and brown adipose tissues, liver, and skeletal muscle). Resveratrol blunts fat accumulation through decreasing adipogenesis and/or de novo lipogenesis in white adipose tissue. The effects on lipolysis are controversial. Regarding brown adipose tissue, resveratrol increases the capacity for adaptive thermogenesis. As far as liver and skeletal muscle is concerned, resveratrol increases lipid oxidation in both tissues. Therefore, in rodents, there is a general consensus concerning the effect of resveratrol on reducing body fat accumulation. By contrast, in humans, the studies are scarce, and no clear antiobesity action has been revealed so far. © 2017 New York Academy of Sciences.

Optimizing the U.S. Electric System with a High Penetration of Renewables

NASA Astrophysics Data System (ADS)

Corcoran, B. A.; Jacobson, M. Z.

2013-12-01

As renewable energy generators are increasingly being installed throughout the U.S., there is growing interest in interconnecting diverse renewable generators (primarily wind and solar) across large geographic areas through an enhanced transmission system. This reduces variability in the aggregate power output, increases system reliability, and allows for the development of the best overall group of renewable technologies and sites to meet the load. Studies are therefore needed to determine the most efficient and economical plan to achieve large area interconnections in a future electric system with a high penetration of renewables. This research quantifies the effects of aggregating electric load together with diverse renewable generation throughout the ten Federal Energy Regulatory Commission (FERC) regions in the contiguous U.S. A deterministic linear program has been built in AMPL (A Mathematical Programming Language) to solve for the least-cost organizational structure and system (generators, transmission, and storage) for a highly renewable electric grid. The analysis will 1) examine a highly renewable 2006 electric system, including various sensitivity cases and additional system components such as additional load from electric vehicles, and 2) create a 'roadmap' from the existing 2006 system to a highly renewable system in 2030, accounting for projected price and demand changes and generator retirements based on age and environmental regulations. Ideally, results from this study will offer insight for a federal renewable energy policy (such as a renewable portfolio standard) and how to best organize U.S. regions for transmission planning.

The value of electricity storage in energy-only electricity markets

NASA Astrophysics Data System (ADS)

McConnell, D.; Forcey, T.; Sandiford, M.

2015-12-01

Price volatility and the prospect of increasing renewable energy generation have raised interest in the potential opportunities for storage technologies in energy-only electricity markets. In this paper we explore the value of a price-taking storage device in such a market, the National Electricity Market (NEM) in Australia. Our analysis suggests that under optimal operation, there is little value in having more than six hours of storage in this market. However, the inability to perfectly forecast wholesale prices, particularly extreme price spikes, may warrant some additional storage. We found that storage devices effectively provide a similar service as peak generators (such as Open Cycle Gas Turbines) and are similarly dependent on and exposed to extreme price events, with revenue for a merchant generator highly skewed to a few days of the year. In contrast to previous studies, this results in the round trip efficiency of the storage being relatively insignificant. Financing using hedging strategies similar to a peak generator effectively reduces the variability of revenue and exposure of storage to extreme prices. Our case study demonstrates that storage may have a competitive advantage over other peaking generators on the NEM, due to its ability to earn revenue outside of extreme peak events. As a consequence the outlook for storage options on the NEM is dependent on volatility, in turn dependent on capacity requirements. Further to this, increased integration of renewable energy may both depend on storage and improve the outlook for storage in technologies in electricity markets.

Small photovoltaic setup for the air conditioning system

NASA Astrophysics Data System (ADS)

Masiukiewicz, Maciej

2017-10-01

The increasing interest in air conditioning systems for residential applications in Poland will certainly increase the demand for electricity during the summer period. Due to this fact a growing interest in solutions that help to lower the electricity consumption in this sector is observed. The problem of increased energy demand for air conditioning purposes can be solved by transfer the consumption of electricity from the grid system to renewable energy sources (RES). The greatest demand for cooling occurs during the biggest sunlight. This is the basis for the analysis of technical power system based on photovoltaic cells (PV) to power the split type air conditioner. The object of the study was the commercial residential airconditioning inverter units with a capacity of 2.5kW. A network electricity production system for their own use with the possibility of buffering energy in batteries (OFF-GRID system). Currently, on the Polish market, there are no developed complete solutions dedicated to air conditioning systems based on PV. In Poland, solar energy is mainly used for heat production in solar collectors. The proposed solution will help to increase the popularity of PV systems in the Polish market as an alternative to other RES. The basic conclusion is that the amount of PV energy generated was sufficient to cover the daily energy requirement of the air conditioner.

[OMICS AND BIG DATA, MAJOR ADVANCES TOWARDS PERSONALIZED MEDICINE OF THE FUTURE?].

PubMed

Scheen, A J

2015-01-01

The increasing interest for personalized medicine evolves together with two major technological advances. First, the new-generation, rapid and less expensive, DNA sequencing method, combined with remarkable progresses in molecular biology leading to the post-genomic era (transcriptomics, proteomics, metabolomics). Second, the refinement of computing tools (IT), which allows the immediate analysis of a huge amount of data (especially, those resulting from the omics approaches) and, thus, creates a new universe for medical research, that of analyzed by computerized modelling. This article for scientific communication and popularization briefly describes the main advances in these two fields of interest. These technological progresses are combined with those occurring in communication, which makes possible the development of artificial intelligence. These major advances will most probably represent the grounds of the future personalized medicine.