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Sample records for generic core scales

  1. Psychometric properties of the self-report Malay version of the Pediatric Quality of Life (PedsQLTM) 4.0 Generic Core Scales among multiethnic Malaysian adolescents.

    PubMed

    Ainuddin, Husna A; Loh, Siew Yim; Chinna, Karuthan; Low, Wah Yun; Roslani, April Camilla

    2015-06-01

    Adolescence is the potential period for growth and optimal functioning, but developmental issues like time of transition from childhood to adulthood will create stress and affect the adolescent's quality of life (QOL). However, there is a lack of research tool for measuring adolescent's QOL in Malaysia. The aim of the study was to determine the validity and reliability of the self-report Malay version of the pediatric QOL (PedsQL™) 4.0 Generic Core Scales in assessing the QOL of Malaysian adolescents. A cross-sectional study design using the 23-item self-report Malay version of the PedsQL 4.0 Generic Core Scales was administered on a convenient cluster sampling (n = 297 adolescent) from a secondary school. The internal consistency reliability had Cronbach's α values ranging from .70 to .89. Factor analysis reported a six-factor structure via principal axis factor analysis. In conclusion, the self-report Malay version of the pediatric QOL 4.0 Generic Core Scales is a reliable and valid tool to measure the QOL of multiethnic Malaysian adolescents.

  2. Health related quality of life in Dutch young adults: psychometric properties of the PedsQL generic core scales young adult version

    PubMed Central

    2014-01-01

    Background The purpose of this study is to provide Dutch norm data and to assess internal consistency and construct validity for the Pediatric Quality of Life Inventory Young Adult Generic Core Scales (PedsQL_YA) in Dutch young adults aged 18–30 years. Methods A sample of 649 young adults from the general Dutch population aged 18–30 years, stratified by age, sex, marital status and education, completed a socio-demographic questionnaire and the Dutch version of the PedsQL_YA online. Internal consistency of the PedsQL_YA scales was determined with Cronbach’s alphas. Norm scores were obtained by calculating the mean PedsQL scale scores by gender, age and health status. Differences in scale scores were analyzed for gender, age and health status (construct validity) using two-sample t-tests and effect sizes were calculated. Construct validity was determined by testing differences in PedsQL scores between healthy young adults and young adults with chronic health conditions. Results All scales of the PedsQL_YA showed satisfactory to excellent internal consistency, with Cronbach’s alphas between .77 and .94. Men reported higher scores (indicating better HRQOL) than women on all scales (p < .01), except for school/work functioning. No age differences were found. Young adults with chronic health conditions scored lower on all scales (p < .001) than healthy young adults, indicating good construct validity. Effect sizes varied from medium to large. Conclusions The Dutch version of the PedsQL_YA has adequate psychometric properties. With the availability of reliable norm data, the PedsQL_YA can be used as a tool in the evaluation of health related quality of life in healthy young adults and those with a chronic health condition. PMID:24438218

  3. Assessing lay beliefs about generic medicines: Development of the generic medicines scale.

    PubMed

    Figueiras, Maria J; Alves, Nuno C; Marcelino, Dália; Cortes, Maria A; Weinman, John; Horne, Rob

    2009-05-01

    The aims of this study were to develop a scale to assess lay beliefs about generic medicines, and to investigate whether these beliefs differ according to demographic factors in an opportunistic general public sample. In the pilot study, the participants were 92 men and 136 women, and in the main study there were 314 men and 505 women. At both stages, the participants completed a questionnaire measuring beliefs about generic medicines, preference for medicines and demographic information. The scale has good face validity, showing a satisfactory level of internal consistency. An exploratory principal component analysis revealed a two-factor structure concerning beliefs about generic medicines, comprising two core themes (efficacy and similarity to brand medicines), in two different samples. Older participants showed a stronger belief in similarity with brand names than the younger group. Higher educated participants showed a stronger belief in the efficacy of generics. The opportunity to assess beliefs about generic medicines may have implications for adherence, for the implementation of health policies and for decision making about medicines. PMID:19444709

  4. Comparison between Utility of the Thai Pediatric Quality of Life Inventory 4.0 Generic Core Scales and 3.0 Cerebral Palsy Module

    ERIC Educational Resources Information Center

    Tantilipikorn, Pinailug; Watter, Pauline; Prasertsukdee, Saipin

    2013-01-01

    Health-related quality of life (HRQOL) is increasingly being considered in the management of patients with various conditions. HRQOL instruments can be broadly classified as generic or disease-specific measures. Several generic HRQOL instruments in different languages have been developed for paediatric populations including the Pediatric Quality…

  5. Initial validation of the Argentinean Spanish version of the PedsQL™ 4.0 Generic Core Scales in children and adolescents with chronic diseases: acceptability and comprehensibility in low-income settings

    PubMed Central

    Roizen, Mariana; Rodríguez, Susana; Bauer, Gabriela; Medin, Gabriela; Bevilacqua, Silvina; Varni, James W; Dussel, Veronica

    2008-01-01

    Background To validate the Argentinean Spanish version of the PedsQL™ 4.0 Generic Core Scales in Argentinean children and adolescents with chronic conditions and to assess the impact of socio-demographic characteristics on the instrument's comprehensibility and acceptability. Reliability, and known-groups, and convergent validity were tested. Methods Consecutive sample of 287 children with chronic conditions and 105 healthy children, ages 2–18, and their parents. Chronically ill children were: (1) attending outpatient clinics and (2) had one of the following diagnoses: stem cell transplant, chronic obstructive pulmonary disease, HIV/AIDS, cancer, end stage renal disease, complex congenital cardiopathy. Patients and adult proxies completed the PedsQL™ 4.0 and an overall health status assessment. Physicians were asked to rate degree of health status impairment. Results The PedsQL™ 4.0 was feasible (only 9 children, all 5 to 7 year-olds, could not complete the instrument), easy to administer, completed without, or with minimal, help by most children and parents, and required a brief administration time (average 5–6 minutes). People living below the poverty line and/or low literacy needed more help to complete the instrument. Cronbach Alpha's internal consistency values for the total and subscale scores exceeded 0.70 for self-reports of children over 8 years-old and parent-reports of children over 5 years of age. Reliability of proxy-reports of 2–4 year-olds was low but improved when school items were excluded. Internal consistency for 5–7 year-olds was low (α range = 0.28–0.76). Construct validity was good. Child self-report and parent proxy-report PedsQL™ 4.0 scores were moderately but significantly correlated (ρ = 0.39, p < 0.0001) and both significantly correlated with physician's assessment of health impairment and with child self-reported overall health status. The PedsQL™ 4.0 discriminated between healthy and chronically ill children (72

  6. Measuring belief in conspiracy theories: the generic conspiracist beliefs scale.

    PubMed

    Brotherton, Robert; French, Christopher C; Pickering, Alan D

    2013-01-01

    The psychology of conspiracy theory beliefs is not yet well understood, although research indicates that there are stable individual differences in conspiracist ideation - individuals' general tendency to engage with conspiracy theories. Researchers have created several short self-report measures of conspiracist ideation. These measures largely consist of items referring to an assortment of prominent conspiracy theories regarding specific real-world events. However, these instruments have not been psychometrically validated, and this assessment approach suffers from practical and theoretical limitations. Therefore, we present the Generic Conspiracist Beliefs (GCB) scale: a novel measure of individual differences in generic conspiracist ideation. The scale was developed and validated across four studies. In Study 1, exploratory factor analysis of a novel 75-item measure of non-event-based conspiracist beliefs identified five conspiracist facets. The 15-item GCB scale was developed to sample from each of these themes. Studies 2, 3, and 4 examined the structure and validity of the GCB, demonstrating internal reliability, content, criterion-related, convergent and discriminant validity, and good test-retest reliability. In sum, this research indicates that the GCB is a psychometrically sound and practically useful measure of conspiracist ideation, and the findings add to our theoretical understanding of conspiracist ideation as a monological belief system unpinned by a relatively small number of generic assumptions about the typicality of conspiratorial activity in the world. PMID:23734136

  7. Measuring Belief in Conspiracy Theories: The Generic Conspiracist Beliefs Scale

    PubMed Central

    Brotherton, Robert; French, Christopher C.; Pickering, Alan D.

    2013-01-01

    The psychology of conspiracy theory beliefs is not yet well understood, although research indicates that there are stable individual differences in conspiracist ideation – individuals’ general tendency to engage with conspiracy theories. Researchers have created several short self-report measures of conspiracist ideation. These measures largely consist of items referring to an assortment of prominent conspiracy theories regarding specific real-world events. However, these instruments have not been psychometrically validated, and this assessment approach suffers from practical and theoretical limitations. Therefore, we present the Generic Conspiracist Beliefs (GCB) scale: a novel measure of individual differences in generic conspiracist ideation. The scale was developed and validated across four studies. In Study 1, exploratory factor analysis of a novel 75-item measure of non-event-based conspiracist beliefs identified five conspiracist facets. The 15-item GCB scale was developed to sample from each of these themes. Studies 2, 3, and 4 examined the structure and validity of the GCB, demonstrating internal reliability, content, criterion-related, convergent and discriminant validity, and good test-retest reliability. In sum, this research indicates that the GCB is a psychometrically sound and practically useful measure of conspiracist ideation, and the findings add to our theoretical understanding of conspiracist ideation as a monological belief system unpinned by a relatively small number of generic assumptions about the typicality of conspiratorial activity in the world. PMID:23734136

  8. Generic eukaryotic core promoter prediction using structural features of DNA.

    PubMed

    Abeel, Thomas; Saeys, Yvan; Bonnet, Eric; Rouzé, Pierre; Van de Peer, Yves

    2008-02-01

    Despite many recent efforts, in silico identification of promoter regions is still in its infancy. However, the accurate identification and delineation of promoter regions is important for several reasons, such as improving genome annotation and devising experiments to study and understand transcriptional regulation. Current methods to identify the core region of promoters require large amounts of high-quality training data and often behave like black box models that output predictions that are difficult to interpret. Here, we present a novel approach for predicting promoters in whole-genome sequences by using large-scale structural properties of DNA. Our technique requires no training, is applicable to many eukaryotic genomes, and performs extremely well in comparison with the best available promoter prediction programs. Moreover, it is fast, simple in design, and has no size constraints, and the results are easily interpretable. We compared our approach with 14 current state-of-the-art implementations using human gene and transcription start site data and analyzed the ENCODE region in more detail. We also validated our method on 12 additional eukaryotic genomes, including vertebrates, invertebrates, plants, fungi, and protists.

  9. Generic BWR-4 degraded core in-vessel study. Status report

    SciTech Connect

    Not Available

    1984-11-01

    Original intent of this project was to produce a phenomenological study of the in-vessel degradation which occurs during the TQUX and TQUV sequences for a generic BWR-4 from the initiation of the FSAR Chapter 15 operational transient through core debris bed formation to the failure of the primary pressure boundary. Bounding calculations were to be performed for the two high pressure and low pressure non-LOCA scenarios to assess the uncertainties in the current state of knowledge regarding the source terms for containment integrity studies. Source terms as such were defined in terms of hydrogen generation, unreacted metal, and coolant inventroy, and in terms of the form, sequencing and mode of dispersal through the primary vessel boundary. Fission product release was not to be considered as part of this study. Premature termination of the project, however, led to the dicontinuation of work on an as is basis. Work on the in-core phase from the point of scram to core debris bed formation was largely completed. A preliminary scoping calculation on the debris bed phase had been initiated. This report documents the status of the study at termination.

  10. A Generic Length-scale Equation For Second-order Turbulence Models of Oceanic Boundary Layers

    NASA Astrophysics Data System (ADS)

    Umlauf, L.; Burchard, H.

    A generic transport equation for a generalized length-scale in second-order turbulence closure models for geophysical boundary layers is suggested. This variable consists of the products of powers of the turbulent kinetic energy, k, and the integral length-scale, l. The new approach generalizes traditional second-order models used in geophysical boundary layer modelling, e.g. the Mellor-Yamada model and the k- model, which, however, can be recovered as special cases. It is demonstrated how this new model can be calibrated with measurements in some typical geophysical boundary layer flows. As an example, the generic model is applied to the uppermost oceanic boundary layer directly influenced by the effects of breaking surface waves. Recent measurements show that in this layer the classical law of the wall is invalid, since there turbulence is dominated by turbulent transport of TKE from above, and not by shear-production. A widely accepted approach to describe the wave-affected layer with a one-equation turbulence model was suggested by Craig and Banner (1994). Here, some deficien- cies of their solutions are pointed out and a generalization of their ideas for the case of two-equation models is suggested. Direct comparison with very recently obtained measurements of the dissipation rate, , in the wave-affected boundary layer with com- puted results clearly demonstrate that only the generic two-equation model yields cor- rect predictions for the profiles of and the turbulent length scale, l. Also, the pre- dicted velocity profiles in the wave-affected layer, important e.g. for the interpretation of surface drifter experiments, are reproduced correctly only by the generic model. Implementation and computational costs of the generic model are comparable with traditonal two-equation models.

  11. Classification as a generic tool for characterising status and changes of regional scale groundwater systems

    NASA Astrophysics Data System (ADS)

    Barthel, Roland; Haaf, Ezra

    2016-04-01

    Regional hydrogeology is becoming increasingly important, but at the same time, scientifically sound, universal solutions for typical groundwater problems encountered on the regional scale are hard to find. While managers, decision-makers and state agencies operating on regional and national levels have always shown a strong interest in regional scale hydrogeology, researchers from academia tend to avoid the subject, focusing instead on local scales. Additionally, hydrogeology has always had a tendency to regard every problem as unique to its own site- and problem-specific context. Regional scale hydrogeology is therefore pragmatic rather than aiming at developing generic methodology (Barthel, 2014; Barthel and Banzhaf, 2016). One of the main challenges encountered on the regional scale in hydrogeology is the extreme heterogeneity that generally increases with the size of the studied area - paired with relative data scarcity. Even in well-monitored regions of the world, groundwater observations are usually clustered, leaving large areas without any direct data. However, there are many good reasons for assessing the status and predicting the behavior of groundwater systems under conditions of global change even for those areas and aquifers without observations. This is typically done by using rather coarsely discretized and / or poorly parameterized numerical models, or by using very simplistic conceptual hydrological models that do not take into account the complex three-dimensional geological setup. Numerical models heavily rely on local data and are resource-demanding. Conceptual hydrological models only deliver reliable information on groundwater if the geology is extremely simple. In this contribution, we present an approach to derive statistically relevant information for un-monitored areas, making use of existing information from similar localities that are or have been monitored. The approach combines site-specific knowledge with conceptual assumptions on

  12. Strong anisotropy in two-dimensional surfaces with generic scale invariance: nonlinear effects.

    PubMed

    Vivo, Edoardo; Nicoli, Matteo; Cuerno, Rodolfo

    2014-04-01

    We expand a previous study [Phys. Rev. E 86, 051611 (2012)] on the conditions for occurrence of strong anisotropy in the scaling properties of two-dimensional surfaces displaying generic scale invariance. In that study, a natural scaling ansatz was proposed for strongly anisotropic systems, which arises naturally when analyzing data from, e.g., thin-film production experiments. The ansatz was tested in Gaussian (linear) models of surface dynamics and in nonlinear models, like the Hwa-Kardar (HK) equation [Phys. Rev. Lett. 62, 1813 (1989)], which are susceptible of accurate approximations through the former. In contrast, here we analyze nonlinear equations for which such approximations fail. Working within generically scale-invariant situations, and as representative case studies, we formulate and study a generalization of the HK equation for conserved dynamics and reconsider well-known systems, such as the conserved and the nonconserved anisotropic Kardar-Parisi-Zhang equations. Through the combined use of dynamic renormalization group analysis and direct numerical simulations, we conclude that the occurrence of strong anisotropy in two-dimensional surfaces requires dynamics to be conserved. We find that, moreover, strong anisotropy is not generic in parameter space but requires, rather, specific forms of the terms appearing in the equation of motion, whose justification needs detailed information on the dynamical process that is being modeled in each particular case. PMID:24827260

  13. Generic, Extensible, Configurable Push-Pull Framework for Large-Scale Science Missions

    NASA Technical Reports Server (NTRS)

    Foster, Brian M.; Chang, Albert Y.; Freeborn, Dana J.; Crichton, Daniel J.; Woollard, David M.; Mattmann, Chris A.

    2011-01-01

    The push-pull framework was developed in hopes that an infrastructure would be created that could literally connect to any given remote site, and (given a set of restrictions) download files from that remote site based on those restrictions. The Cataloging and Archiving Service (CAS) has recently been re-architected and re-factored in its canonical services, including file management, workflow management, and resource management. Additionally, a generic CAS Crawling Framework was built based on motivation from Apache s open-source search engine project called Nutch. Nutch is an Apache effort to provide search engine services (akin to Google), including crawling, parsing, content analysis, and indexing. It has produced several stable software releases, and is currently used in production services at companies such as Yahoo, and at NASA's Planetary Data System. The CAS Crawling Framework supports many of the Nutch Crawler's generic services, including metadata extraction, crawling, and ingestion. However, one service that was not ported over from Nutch is a generic protocol layer service that allows the Nutch crawler to obtain content using protocol plug-ins that download content using implementations of remote protocols, such as HTTP, FTP, WinNT file system, HTTPS, etc. Such a generic protocol layer would greatly aid in the CAS Crawling Framework, as the layer would allow the framework to generically obtain content (i.e., data products) from remote sites using protocols such as FTP and others. Augmented with this capability, the Orbiting Carbon Observatory (OCO) and NPP (NPOESS Preparatory Project) Sounder PEATE (Product Evaluation and Analysis Tools Elements) would be provided with an infrastructure to support generic FTP-based pull access to remote data products, obviating the need for any specialized software outside of the context of their existing process control systems. This extensible configurable framework was created in Java, and allows the use of

  14. The Core Self-Evaluation Scale: Further Construct Validation Evidence

    ERIC Educational Resources Information Center

    Gardner, Donald G.; Pierce, Jon L.

    2010-01-01

    The authors empirically examined two operationalizations of the core self-evaluation construct: (a) the Judge, Erez, Bono, and Thoresen 12-item scale and (b) a composite measure of self-esteem, self-efficacy, locus of control, and neuroticism.The study found that the composite scale relates more strongly than the shorter scale to performance,…

  15. Report on large scale molten core/magnesia interaction test

    SciTech Connect

    Chu, T.Y.; Bentz, J.H.; Arellano, F.E.; Brockmann, J.E.; Field, M.E.; Fish, J.D.

    1984-08-01

    A molten core/material interaction experiment was performed at the Large-Scale Melt Facility at Sandia National Laboratories. The experiment involved the release of 230 kg of core melt, heated to 2923/sup 0/K, into a magnesia brick crucible. Descriptions of the facility, the melting technology, as well as results of the experiment, are presented. Preliminary evaluations of the results indicate that magnesia brick can be a suitable material for core ladle construction.

  16. Can manual ability be measured with a generic ABILHAND scale? A cross-sectional study conducted on six diagnostic groups

    PubMed Central

    Arnould, Carlyne; Vandervelde, Laure; Batcho, Charles Sèbiyo; Penta, Massimo; Thonnard, Jean-Louis

    2012-01-01

    Objectives Several ABILHAND Rasch-built manual ability scales were previously developed for chronic stroke (CS), cerebral palsy (CP), rheumatoid arthritis (RA), systemic sclerosis (SSc) and neuromuscular disorders (NMD). The present study aimed to explore the applicability of a generic manual ability scale unbiased by diagnosis and to study the nature of manual ability across diagnoses. Design Cross-sectional study. Setting Outpatient clinic homes (CS, CP, RA), specialised centres (CP), reference centres (CP, NMD) and university hospitals (SSc). Participants 762 patients from six diagnostic groups: 103 CS adults, 113 CP children, 112 RA adults, 156 SSc adults, 124 NMD children and 124 NMD adults. Primary and secondary outcome measures Manual ability as measured by the ABILHAND disease-specific questionnaires, diagnosis and nature (ie, uni-manual or bi-manual involvement and proximal or distal joints involvement) of the ABILHAND manual activities. Results The difficulties of most manual activities were diagnosis dependent. A principal component analysis highlighted that 57% of the variance in the item difficulty between diagnoses was explained by the symmetric or asymmetric nature of the disorders. A generic scale was constructed, from a metric point of view, with 11 items sharing a common difficulty among diagnoses and 41 items displaying a category-specific location (asymmetric: CS, CP; and symmetric: RA, SSc, NMD). This generic scale showed that CP and NMD children had significantly less manual ability than RA patients, who had significantly less manual ability than CS, SSc and NMD adults. However, the generic scale was less discriminative and responsive to small deficits than disease-specific instruments. Conclusions Our finding that most of the manual item difficulties were disease-dependent emphasises the danger of using generic scales without prior investigation of item invariance across diagnostic groups. Nevertheless, a generic manual ability scale could be

  17. Development of a Dynamically Scaled Generic Transport Model Testbed for Flight Research Experiments

    NASA Technical Reports Server (NTRS)

    Jordan, Thomas; Langford, William; Belcastro, Christine; Foster, John; Shah, Gautam; Howland, Gregory; Kidd, Reggie

    2004-01-01

    This paper details the design and development of the Airborne Subscale Transport Aircraft Research (AirSTAR) test-bed at NASA Langley Research Center (LaRC). The aircraft is a 5.5% dynamically scaled, remotely piloted, twin-turbine, swept wing, Generic Transport Model (GTM) which will be used to provide an experimental flight test capability for research experiments pertaining to dynamics modeling and control beyond the normal flight envelope. The unique design challenges arising from the dimensional, weight, dynamic (inertial), and actuator scaling requirements necessitated by the research community are described along with the specific telemetry and control issues associated with a remotely piloted subscale research aircraft. Development of the necessary operational infrastructure, including operational and safety procedures, test site identification, and research pilots is also discussed. The GTM is a unique vehicle that provides significant research capacity due to its scaling, data gathering, and control characteristics. By combining data from this testbed with full-scale flight and accident data, wind tunnel data, and simulation results, NASA will advance and validate control upset prevention and recovery technologies for transport aircraft, thereby reducing vehicle loss-of-control accidents resulting from adverse and upset conditions.

  18. Large-scale molten core/material interaction experiments

    SciTech Connect

    Chu, T.Y.

    1984-01-01

    The paper described the facility and melting technology for large-scale molten core/material interaction experiments being carried out at Sandia National Laboratories. The facility is largest of its kind anywhere. It is capable of producing core melts up to 500 kg at a temperature of 3000/sup 0/K. Results of a recent experiment involving the release of 230 kg of core melt into a magnesia brick crucible is discussed in detail. Data on thermal and mechanical responses of magnesia brick, heat flux partitioning, melt penetration, gas and aerosol generation are presented.

  19. Investigation of Aerodynamics Scale Effects for a Generic Fighter Configuration in the National Transonic Facility (Invited)

    NASA Technical Reports Server (NTRS)

    Tomek, W. G.; Wahls, R. A.; Owens, L. R.; Burner, A. B.; Graves, S. S.; Luckring, J. M.

    2003-01-01

    Two wind tunnel tests of a generic fighter configuration have been completed in the National Transonic Facility. The primary purpose of the tests was to assess Reynolds number scale effects on a thin-wing, fighter-type configuration up to full-scale flight conditions (that is, Reynolds numbers of the order of 60 million). The tests included longitudinal and lateral/directional studies at subsonic and transonic conditions across a range of Reynolds numbers from that available in conventional wind tunnels to flight conditions. Results are presented for three Mach numbers (0.6, 0.8, and 0.9) and three configurations: 1) Fuselage / Wing, 2) Fuselage / Wing / Centerline Vertical Tail / Horizontal Tail, and 3) Fuselage / Wing / Trailing-Edge Extension / Twin Vertical Tails. Reynolds number effects on the lateral-directional aerodynamic characteristics are presented herein, along with longitudinal data demonstrating the effects of fixing the boundary layer transition location for low Reynolds number conditions. In addition, an improved model videogrammetry system and results are discussed.

  20. Simplicity of condensed matter at its core: generic definition of a Roskilde-simple system.

    PubMed

    Schrøder, Thomas B; Dyre, Jeppe C

    2014-11-28

    The isomorph theory is reformulated by defining Roskilde-simple systems by the property that the order of the potential energies of configurations at one density is maintained when these are scaled uniformly to a different density. If the potential energy as a function of all particle coordinates is denoted by U(R), this requirement translates into U(Ra) < U(Rb) ⇒ U(λRa) < U(λRb). Isomorphs remain curves in the thermodynamic phase diagram along which structure, dynamics, and excess entropy are invariant, implying that the phase diagram is effectively one-dimensional with respect to many reduced-unit properties. In contrast to the original formulation of the isomorph theory, however, the density-scaling exponent is not exclusively a function of density and the isochoric heat capacity is not an exact isomorph invariant. A prediction is given for the latter quantity's variation along the isomorphs. Molecular dynamics simulations of the Lennard-Jones and Lennard-Jones Gaussian systems validate the new approach.

  1. Simplicity of condensed matter at its core: Generic definition of a Roskilde-simple system

    SciTech Connect

    Schrøder, Thomas B. Dyre, Jeppe C.

    2014-11-28

    The isomorph theory is reformulated by defining Roskilde-simple systems by the property that the order of the potential energies of configurations at one density is maintained when these are scaled uniformly to a different density. If the potential energy as a function of all particle coordinates is denoted by U(R), this requirement translates into U(R{sub a}) < U(R{sub b}) ⇒ U(λR{sub a}) < U(λR{sub b}). Isomorphs remain curves in the thermodynamic phase diagram along which structure, dynamics, and excess entropy are invariant, implying that the phase diagram is effectively one-dimensional with respect to many reduced-unit properties. In contrast to the original formulation of the isomorph theory, however, the density-scaling exponent is not exclusively a function of density and the isochoric heat capacity is not an exact isomorph invariant. A prediction is given for the latter quantity's variation along the isomorphs. Molecular dynamics simulations of the Lennard-Jones and Lennard-Jones Gaussian systems validate the new approach.

  2. Simplicity of condensed matter at its core: Generic definition of a Roskilde-simple system

    NASA Astrophysics Data System (ADS)

    Schrøder, Thomas B.; Dyre, Jeppe C.

    2014-11-01

    The isomorph theory is reformulated by defining Roskilde-simple systems by the property that the order of the potential energies of configurations at one density is maintained when these are scaled uniformly to a different density. If the potential energy as a function of all particle coordinates is denoted by U(R), this requirement translates into U(Ra) < U(Rb) ⇒ U(λRa) < U(λRb). Isomorphs remain curves in the thermodynamic phase diagram along which structure, dynamics, and excess entropy are invariant, implying that the phase diagram is effectively one-dimensional with respect to many reduced-unit properties. In contrast to the original formulation of the isomorph theory, however, the density-scaling exponent is not exclusively a function of density and the isochoric heat capacity is not an exact isomorph invariant. A prediction is given for the latter quantity's variation along the isomorphs. Molecular dynamics simulations of the Lennard-Jones and Lennard-Jones Gaussian systems validate the new approach.

  3. Fine-scale heterogeneity in the Earth's inner core

    PubMed

    Vidale; Earle

    2000-03-16

    The seismological properties of the Earth's inner core have become of particular interest as we understand more about its composition and thermal state. Observations of anisotropy and velocity heterogeneity in the inner core are beginning to reveal how it has grown and whether it convects. The attenuation of seismic waves in the inner core is strong, and studies of seismic body waves have found that this high attenuation is consistent with either scattering or intrinsic attenuation. The outermost portion of the inner core has been inferred to possess layering and to be less anisotropic than at greater depths. Here we present observations of seismic waves scattered in the inner core which follow the expected arrival time of the body-wave reflection from the inner-core boundary. The amplitude of these scattered waves can be explained by stiffness variations of 1.2% with a scale length of 2 kilometres across the outermost 300 km of the inner core. These variations might be caused by variations in composition, by pods of partial melt in a mostly solid matrix or by variations in the orientation or strength of seismic anisotropy.

  4. The bluetongue virus core: a nano-scale transcription machine.

    PubMed

    Mertens, Peter P C; Diprose, Jonathan

    2004-04-01

    The replication phase of the bluetongue virus (BTV) infection cycle is initiated when the virus core is delivered into the cytoplasm of a susceptible host cell. The 10 segments of the viral genome remain packaged within the core throughout the replication cycle, helping to prevent the activation of host defence mechanisms that would be caused by direct contact between the dsRNA and the host cell cytoplasm. However, the BTV core is a biochemically active 'nano-scale' machine, which can simultaneously and repeatedly transcribe mRNA from each of the 10 genome segments, which are packaged as a liquid crystal array within a central cavity. These mRNAs, which are also capped and methylated within the core, are extruded into the cytoplasm through pores at the vertices of the icosahedral structure, where they are translated into viral proteins. One copy of each of the viral mRNAs is also assembled with these newly synthesised proteins to form nascent virus particles, which mature by a process that involves -ve RNA strand synthesis on the +ve stand template, thereby reforming dsRNA genome segments within progeny virus cores. The structure of the BTV core particle has been determined to atomic resolution by X-ray crystallography, revealing the organisation and interactions of its major protein components (VP3(T2)-subcore shell and VP7(T13) outer core layer) and important features of the packaged dsRNA. By soaking crystals of BTV cores with metal ions and substrates/products of the transcription reactions prior to analysis by X-ray crystallography, then constructing difference maps, it has been possible to identify binding sites and entry/exit routes for these ions, substrates and products. This has revealed how BTV solves the many logistical problems of multiple and simultaneous transcription from the 10 genome segments within the confined space of the core particle. The crystal structure of the BTV core has also revealed an outer surface festooned with dsRNA. This may

  5. NMR provides checklist of generic properties for atomic-scale models of periodic mesoporous silicas.

    PubMed

    Shenderovich, Ilja G; Mauder, Daniel; Akcakayiran, Dilek; Buntkowsky, Gerd; Limbach, Hans-Heinrich; Findenegg, Gerhard H

    2007-10-25

    MCM-41 and SBA-15 silicas were studied by (29)Si solid-state NMR and (15)N NMR in the presence of (15)N-pyridine with the aim to formulate generic structural parameters that may be used as a checklist for atomic-scale structural models of this class of ordered mesoporous materials. High-quality MCM-41 silica constitutes quasi-ideal arrays of uniform-size pores with thin pore walls, while SBA-15 silica has thicker pore walls with framework and surface defects. The numbers of silanol (Q(3)) and silicate (Q(4)) groups were found to be in the ratio of about 1:3 for MCM-41 and about 1:4 for our SBA-15 materials. Combined with the earlier finding that the density of surface silanol groups is about three per nm(2) in MCM-41 (Shenderovich, et al. J. Phys. Chem. B 2003, 107, 11924) this allows us to discriminate between different atomic-scale models of these materials. Neither tridymite nor edingtonite meet both of these requirements. On the basis of the hexagonal pore shape model, the experimental Q(3):Q(4) ratio yields a wall thickness of about 0.95 nm for MCM-41 silica, corresponding to the width of ca. four silica tetrahedra. The arrangement of Q(3) groups at the silica surfaces was analyzed using postsynthesis surface functionalization. It was found that the number of covalent bonds to the surface formed by the functional reagents is affected by the surface morphology. It is concluded that for high-quality MCM-41 silicas the distance between neighboring surface silanol groups is greater than 0.5 nm. As a result, di- and tripodical reagents like (CH(3))(2)Si(OH)(2) and CH(3)Si(OH)(3) can form only one covalent bond to the surface. The residual hydroxyl groups of surface-bonded functional reagents either remain free or interact with other reagent molecules. Accordingly, the number of surface silanol groups at a given MCM-41 or SBA-15 silica may not decrease but increase after treatment with CH(3)Si(OH)(3) reagent. On the other hand, nearly all surface silanol groups

  6. Performance of four turbulence closure models implemented using a generic length scale method

    USGS Publications Warehouse

    Warner, J.C.; Sherwood, C.R.; Arango, H.G.; Signell, R.P.

    2005-01-01

    A two-equation turbulence model (one equation for turbulence kinetic energy and a second for a generic turbulence length-scale quantity) proposed by Umlauf and Burchard [J. Marine Research 61 (2003) 235] is implemented in a three-dimensional oceanographic model (Regional Oceanographic Modeling System; ROMS v2.0). These two equations, along with several stability functions, can represent many popular turbulence closures, including the k-kl (Mellor-Yamada Level 2.5), k-??, and k-?? schemes. The implementation adds flexibility to the model by providing an unprecedented range of turbulence closure selections in a single 3D oceanographic model and allows comparison and evaluation of turbulence models in an otherwise identical numerical environment. This also allows evaluation of the effect of turbulence models on other processes such as suspended-sediment distribution or ecological processes. Performance of the turbulence models and sediment-transport schemes is investigated with three test cases for (1) steady barotropic flow in a rectangular channel, (2) wind-induced surface mixed-layer deepening in a stratified fluid, and (3) oscillatory stratified pressure-gradient driven flow (estuarine circulation) in a rectangular channel. Results from k-??, k-??, and gen (a new closure proposed by Umlauf and Burchard [J. Marine Research 61 (2003) 235]) are very similar for these cases, but the k-kl closure results depend on a wall-proximity function that must be chosen to suit the flow. Greater variations appear in simulations of suspended-sediment concentrations than in salinity simulations because the transport of suspended-sediment amplifies minor variations in the methods. The amplification is caused by the added physics of a vertical settling rate, bottom stress dependent resuspension, and diffusive transport of sediment in regions of well mixed salt and temperature. Despite the amplified sensitivity of sediment to turbulence models in the estuary test case, the four

  7. Small scale folding observed in the NEEM ice core

    NASA Astrophysics Data System (ADS)

    Jansen, Daniela; Llorens, Maria-Gema; Westhoff, Julien; Steinbach, Florian; Bons, Paul D.; Kipfstuhl, Sepp; Griera, Albert; Weikusat, Ilka

    2015-04-01

    Disturbances on the centimeter scale in the layering of the NEEM ice core (North Greenland) can be mapped by means of visual stratigraphy as long as the ice does have a visual layering, such as, for example, cloudy bands. Different focal depths of the visual stratigraphy method allow, to a certain extent, a three dimensional view of the structures. In this study we present a structural analysis of the visible folds, discuss characteristics and frequency and present examples of typical fold structures. With this study we aim to quantify the potential impact of small scale folding on the integrity of climate proxy data. We also analyze the structures with regard to the stress environment under which they formed. The structures evolve from gentle waves at about 1700 m to overturned z-folds with increasing depth. Occasionally, the folding causes significant thickening of layers. Their shape indicates that they are passive features and are probably not initiated by rheology differences between layers. Layering is heavily disturbed and tracing of single layers is no longer possible below a depth of 2160 m. Lattice orientation distributions for the corresponding core sections were analyzed where available in addition to visual stratigraphy. The data show axial-plane parallel strings of grains with c.axis orientations that deviate from that of the matrix, which has more or less a single-maximum fabric at the depth where the folding occurs. We conclude from these data that folding is a consequence of deformation along localized shear planes and kink bands. The findings are compared with results from other deep ice cores. The observations presented are supplemented by microstructural modeling using a crystal plasticity code that reproduces deformation, applying a Fast Fourier Transform (FFT), coupled with ELLE to include dynamic recrystallization processes. The model results reproduce the development of bands of grains with a tilted orientation relative to the single maximum

  8. Validation Results for Core-Scale Oil Shale Pyrolysis

    SciTech Connect

    Staten, Josh; Tiwari, Pankaj

    2015-03-01

    This report summarizes a study of oil shale pyrolysis at various scales and the subsequent development a model for in situ production of oil from oil shale. Oil shale from the Mahogany zone of the Green River formation was used in all experiments. Pyrolysis experiments were conducted at four scales, powdered samples (100 mesh) and core samples of 0.75”, 1” and 2.5” diameters. The batch, semibatch and continuous flow pyrolysis experiments were designed to study the effect of temperature (300°C to 500°C), heating rate (1°C/min to 10°C/min), pressure (ambient and 500 psig) and size of the sample on product formation. Comprehensive analyses were performed on reactants and products - liquid, gas and spent shale. These experimental studies were designed to understand the relevant coupled phenomena (reaction kinetics, heat transfer, mass transfer, thermodynamics) at multiple scales. A model for oil shale pyrolysis was developed in the COMSOL multiphysics platform. A general kinetic model was integrated with important physical and chemical phenomena that occur during pyrolysis. The secondary reactions of coking and cracking in the product phase were addressed. The multiscale experimental data generated and the models developed provide an understanding of the simultaneous effects of chemical kinetics, and heat and mass transfer on oil quality and yield. The comprehensive data collected in this study will help advance the move to large-scale in situ oil production from the pyrolysis of oil shale.

  9. A Bioequivalence Approach for Generic Narrow Therapeutic Index Drugs: Evaluation of the Reference-Scaled Approach and Variability Comparison Criterion.

    PubMed

    Jiang, Wenlei; Makhlouf, Fairouz; Schuirmann, Donald J; Zhang, Xinyuan; Zheng, Nan; Conner, Dale; Yu, Lawrence X; Lionberger, Robert

    2015-07-01

    Various health communities have expressed concerns regarding whether average bioequivalence (BE) limits (80.00-125.00%) for the 90% confidence interval of the test-to-reference geometric mean ratio are sufficient to ensure therapeutic equivalence between a generic narrow therapeutic index (NTI) drug and its reference listed drug (RLD). Simulations were conducted to investigate the impact of different BE approaches for NTI drugs on study power, including (1) direct tightening of average BE limits and (2) a scaled average BE approach where BE limits are tightened based on the RLD's within-subject variability. Addition of a variability comparison (using a one-tailed F test) increased the difficulty for generic NTIs more variable than their corresponding RLDs to demonstrate bioequivalence. Based on these results, the authors evaluate the fully replicated, 2-sequence, 2-treatment, 4-period crossover study design for NTI drugs where the test product demonstrates BE based on a scaled average bioequivalence criterion and a within-subject variability comparison criterion.

  10. Can key vegetation parameters be retrieved at the large-scale using LAI satellite products and a generic modelling approach ?

    NASA Astrophysics Data System (ADS)

    Dewaele, Helene; Calvet, Jean-Christophe; Carrer, Dominique; Laanaia, Nabil

    2016-04-01

    In the context of climate change, the need to assess and predict the impact of droughts on vegetation and water resources increases. The generic approaches permitting the modelling of continental surfaces at large-scale has progressed in recent decades towards land surface models able to couple cycles of water, energy and carbon. A major source of uncertainty in these generic models is the maximum available water content of the soil (MaxAWC) usable by plants which is constrained by the rooting depth parameter and unobservable at the large-scale. In this study, vegetation products derived from the SPOT/VEGETATION satellite data available since 1999 are used to optimize the model rooting depth over rainfed croplands and permanent grasslands at 1 km x 1 km resolution. The inter-annual variability of the Leaf Area Index (LAI) is simulated over France using the Interactions between Soil, Biosphere and Atmosphere, CO2-reactive (ISBA-A-gs) generic land surface model and a two-layer force-restore (FR-2L) soil profile scheme. The leaf nitrogen concentration directly impacts the modelled value of the maximum annual LAI. In a first step this parameter is estimated for the last 15 years by using an iterative procedure that matches the maximum values of LAI modelled by ISBA-A-gs to the highest satellite-derived LAI values. The Root Mean Square Error (RMSE) is used as a cost function to be minimized. In a second step, the model rooting depth is optimized in order to reproduce the inter-annual variability resulting from the drought impact on the vegetation. The evaluation of the retrieved soil rooting depth is achieved using the French agricultural statistics of Agreste. Retrieved leaf nitrogen concentrations are compared with values from previous studies. The preliminary results show a good potential of this approach to estimate these two vegetation parameters (leaf nitrogen concentration, MaxAWC) at the large-scale over grassland areas. Besides, a marked impact of the

  11. Development of the Transport Class Model (TCM) Aircraft Simulation From a Sub-Scale Generic Transport Model (GTM) Simulation

    NASA Technical Reports Server (NTRS)

    Hueschen, Richard M.

    2011-01-01

    A six degree-of-freedom, flat-earth dynamics, non-linear, and non-proprietary aircraft simulation was developed that is representative of a generic mid-sized twin-jet transport aircraft. The simulation was developed from a non-proprietary, publicly available, subscale twin-jet transport aircraft simulation using scaling relationships and a modified aerodynamic database. The simulation has an extended aerodynamics database with aero data outside the normal transport-operating envelope (large angle-of-attack and sideslip values). The simulation has representative transport aircraft surface actuator models with variable rate-limits and generally fixed position limits. The simulation contains a generic 40,000 lb sea level thrust engine model. The engine model is a first order dynamic model with a variable time constant that changes according to simulation conditions. The simulation provides a means for interfacing a flight control system to use the simulation sensor variables and to command the surface actuators and throttle position of the engine model.

  12. The Chado Natural Diversity module: a new generic database schema for large-scale phenotyping and genotyping data

    PubMed Central

    Jung, Sook; Menda, Naama; Redmond, Seth; Buels, Robert M.; Friesen, Maren; Bendana, Yuri; Sanderson, Lacey-Anne; Lapp, Hilmar; Lee, Taein; MacCallum, Bob; Bett, Kirstin E.; Cain, Scott; Clements, Dave; Mueller, Lukas A.; Main, Dorrie

    2011-01-01

    Linking phenotypic with genotypic diversity has become a major requirement for basic and applied genome-centric biological research. To meet this need, a comprehensive database backend for efficiently storing, querying and analyzing large experimental data sets is necessary. Chado, a generic, modular, community-based database schema is widely used in the biological community to store information associated with genome sequence data. To meet the need to also accommodate large-scale phenotyping and genotyping projects, a new Chado module called Natural Diversity has been developed. The module strictly adheres to the Chado remit of being generic and ontology driven. The flexibility of the new module is demonstrated in its capacity to store any type of experiment that either uses or generates specimens or stock organisms. Experiments may be grouped or structured hierarchically, whereas any kind of biological entity can be stored as the observed unit, from a specimen to be used in genotyping or phenotyping experiments, to a group of species collected in the field that will undergo further lab analysis. We describe details of the Natural Diversity module, including the design approach, the relational schema and use cases implemented in several databases. PMID:22120662

  13. Generic finite size scaling for discontinuous nonequilibrium phase transitions into absorbing states.

    PubMed

    de Oliveira, M M; da Luz, M G E; Fiore, C E

    2015-12-01

    Based on quasistationary distribution ideas, a general finite size scaling theory is proposed for discontinuous nonequilibrium phase transitions into absorbing states. Analogously to the equilibrium case, we show that quantities such as response functions, cumulants, and equal area probability distributions all scale with the volume, thus allowing proper estimates for the thermodynamic limit. To illustrate these results, five very distinct lattice models displaying nonequilibrium transitions-to single and infinitely many absorbing states-are investigated. The innate difficulties in analyzing absorbing phase transitions are circumvented through quasistationary simulation methods. Our findings (allied to numerical studies in the literature) strongly point to a unifying discontinuous phase transition scaling behavior for equilibrium and this important class of nonequilibrium systems. PMID:26764651

  14. Effect of wettability on scale-up of multiphase flow from core-scale to reservoir fine-grid-scale

    SciTech Connect

    Chang, Y.C.; Mani, V.; Mohanty, K.K.

    1997-08-01

    Typical field simulation grid-blocks are internally heterogeneous. The objective of this work is to study how the wettability of the rock affects its scale-up of multiphase flow properties from core-scale to fine-grid reservoir simulation scale ({approximately} 10{prime} x 10{prime} x 5{prime}). Reservoir models need another level of upscaling to coarse-grid simulation scale, which is not addressed here. Heterogeneity is modeled here as a correlated random field parameterized in terms of its variance and two-point variogram. Variogram models of both finite (spherical) and infinite (fractal) correlation length are included as special cases. Local core-scale porosity, permeability, capillary pressure function, relative permeability functions, and initial water saturation are assumed to be correlated. Water injection is simulated and effective flow properties and flow equations are calculated. For strongly water-wet media, capillarity has a stabilizing/homogenizing effect on multiphase flow. For small variance in permeability, and for small correlation length, effective relative permeability can be described by capillary equilibrium models. At higher variance and moderate correlation length, the average flow can be described by a dynamic relative permeability. As the oil wettability increases, the capillary stabilizing effect decreases and the deviation from this average flow increases. For fractal fields with large variance in permeability, effective relative permeability is not adequate in describing the flow.

  15. How is kinematic structure connected to the core scale from filament scale?; Mopra mapping observations with multi-lines of dense cores in Lupus I

    NASA Astrophysics Data System (ADS)

    Kiyokane, Kazuhiro; Saito, Masao; Tachihara, Kengo; Saigo, Kazuya; van Kempen, Tim; Cortes, Paulo; Hill, Tracey; Knee, Lewis; Kurono, Yasutaka; Takahashi, Satoko; Aya, Higuchi; Nyman, Lars-Ake

    2014-06-01

    Recently, high sensitivity mappings of nearby molecular clouds in far-infrared and submillimeter wavelengths with Hershel and AzTEC/ASTE show ubiquitous existence of the filamentary structures with 0.1-pc uniform width. It is important to investigate dense core formation from large scale structure via fragmentation. We have conducted MOPRA multi-line mapping observations covered on 0.02 - 0.2 pc scales of 8 dense cores in a filamentary cloud of nearby Lupus I at 140 pc. A class 0/I protostellar core IRAS 15398-3359 is included as a sample, which has an adjacent prestellar core with the separation of 0.13pc in the west. The maps of N2H+, HNC, HC3N show well associated with each core. The velocity field of C18O shows 1.4 km/s/pc from north to south over the region containing two dense cores, which is consistent with past observation of NANTEN. In contrast to C18O results, the velocity field of HC3N shows different structures, which suggest counter rotation of two dense cores; 1.2 km/s/pc from north-west to south-east around a protostellar core and 0.8 km/s/pc from east to west around a presteller core. The filament will be fragmentized and collapsed to dense cores when the line density is over 2Cs/G (where Cs is sound speed and G is gravitational constant). If that velocity gradient was caused by such situation, it should be red-blue-red-blue across two dense cores but the observed kinematics is not consistent with this scenario, which requires that the filament structure would be extremely curved with a skew angle. Although we cannot reject the collapsing interruption, those results suggest the spin-up rotating picture separated from large-scale structure.

  16. Generic EO sensor simulator

    NASA Astrophysics Data System (ADS)

    Akerman, Alexander, III; Hoffman, George A., Jr.

    1988-01-01

    A generic sensor simulation has been developed which emulates the imagery produced by closed circuit television sensors. Applications to date include a monochromatic vidicon and a color CCD camera. The core software program was extracted from the MARSAM II model embedded within the Avionics Laboratory Sensor Performance Model (ALSPM).

  17. Psychometric testing of an instrument measuring core competencies of nursing students: an application of Mokken scaling.

    PubMed

    Perng, Shoa-Jen; Watson, Roger

    2013-01-01

    Assessing the core competencies of nursing students provides information about students' learning outcomes for educational evaluation and improvement. The aim of this study was to develop the Nursing Students Core Competencies scale to measure 8 core competencies of nursing students in Taiwan. The study employed factor analysis and Mokken scaling analysis for psychometric testing of this instrument between a group of nursing graduates and their evaluators. The results indicated that the Nursing Students Core Competencies scale has demonstrated evidence of internal consistency, structural validity, unidimensionality, and a hierarchy of items for students' self-assessment and instructor's rating. The use of Mokken scaling analysis extends the knowledge of developing competence assessment tools; it can be used to reveal the domains or items of competency nursing students perceive that are easy or difficult, providing information for curricular design.

  18. Development of a Korean version of a core self-evaluations scale.

    PubMed

    Holt, Daniel T; Jung, Hee-Hyong

    2008-10-01

    The present study tested a scale which measures core self-evaluation and was applied to two samples of Korean military members (Sample 1 N=181; Sample 2 N=280). Analysis indicated that seven items of the original 12-item scale developed by Judge, Erez, Bono, and Thoresen loaded on one factor and were internally consistent. Moreover, scores were correlated, as expected, with the four core traits which have been used as indirect measures of core self-evaluations (viz., self-esteem, generalized self-efficacy, neuroticism, and locus of control), as well as affect and job satisfaction. In sum, results suggest that core self-evaluation can be measured validly in an Eastern culture, and the results should serve as a basis for extending this research in an international setting. PMID:19102465

  19. Using Profile Analysis via Multidimensional Scaling (PAMS) to identify core profiles from the WMS-III.

    PubMed

    Frisby, Craig L; Kim, Se-Kang

    2008-03-01

    Profile Analysis via Multidimensional Scaling (PAMS) is a procedure for extracting latent core profiles in a multitest data set. The PAMS procedure offers several advantages compared with other profile analysis procedures. Most notably, PAMS estimates individual profile weights that reflect the degree to which an individual's observed profile approximates the shape and scatter of latent core profiles. The PAMS procedure was applied to index scores of nonreplicated participants from the standardization sample (N = 1,033) for the Wechsler Memory Scale--Third Edition (D. Tulsky, J. Zhu, & M. F. Ledbetter, 2002). PAMS extracted discrepant visual memory and auditory memory versus working memory core profiles for the complete 16- to 89-year-old sample and discrepant working memory and auditory memory versus working memory core profiles for the 75- to 89-year-old cohort. Implications for use of PAMS in future research are discussed.

  20. Generic safety documentation model

    SciTech Connect

    Mahn, J.A.

    1994-04-01

    This document is intended to be a resource for preparers of safety documentation for Sandia National Laboratories, New Mexico facilities. It provides standardized discussions of some topics that are generic to most, if not all, Sandia/NM facilities safety documents. The material provides a ``core`` upon which to develop facility-specific safety documentation. The use of the information in this document will reduce the cost of safety document preparation and improve consistency of information.

  1. Power scaling estimate of crystalline fiber waveguides with rare earth doped YAG cores

    NASA Astrophysics Data System (ADS)

    Li, Da; Hong, Pengda; Meissner, Stephanie K.; Meissner, Helmuth E.

    2016-03-01

    Power scaling analysis based on the model by Dawson et al. [1,2] for circular core fibers has been applied to estimating power scaling of crystalline fiber waveguides (CFWs) with RE3+ doped single crystalline or ceramic YAG (RE=rare earth: Yb, Er, Tm and Ho). Power scaling limits include stimulated Brillouin scattering, thermal lensing effect, and limits to coupling of pump light into CFWs. The CFW designs we have considered consist, in general, of a square doped RE3+:YAG core, an inner cladding of either undoped or laser-inactive-ion-doped YAG and an outer cladding of sapphire. The presented data have been developed for the structures fabricated using the Adhesive-Free Bonding (AFB®) technique, but the results should be essentially independent of fabrication technique, assuming perfect core/inner cladding/outer cladding interfaces. Hard power scaling limits exist for a specific CFW design and are strongly based on the physical constants of the material and its spectroscopic specifics. For example, power scaling limit was determined as ~16 kW for 2.5% ceramic Yb:YAG/YAG (core material/inner cladding material) at fiber length of 1.7 m and core diameter of 69 μm. Considering the present manufacturing limit for CFW length to be, e.g., 0.5 m, the actual maximum output power will be limited to ~4.4 kW for a Yb:YAG/YAG CFW. Power limit estimates have also been computed for Er3+, Tm3+ and Ho3+doped core based CFWs.

  2. PWR core and spent fuel pool analysis using scale and nestle

    SciTech Connect

    Murphy, J. E.; Maldonado, G. I.; St Clair, R.; Orr, D.

    2012-07-01

    The SCALE nuclear analysis code system [SCALE, 2011], developed and maintained at Oak Ridge National Laboratory (ORNL) is widely recognized as high quality software for analyzing nuclear systems. The SCALE code system is composed of several validated computer codes and methods with standard control sequences, such as the TRITON/NEWT lattice physics sequence, which supplies dependable and accurate analyses for industry, regulators, and academia. Although TRITON generates energy-collapsed and space-homogenized few group cross sections, SCALE does not include a full-core nodal neutron diffusion simulation module within. However, in the past few years, the open-source NESTLE core simulator [NESTLE, 2003], originally developed at North Carolina State Univ. (NCSU), has been updated and upgraded via collaboration between ORNL and the Univ. of Tennessee (UT), so it now has a growingly seamless coupling to the TRITON/NEWT lattice physics [Galloway, 2010]. This study presents the methodology used to couple lattice physics data between TRITON and NESTLE in order to perform a three-dimensional full-core analysis employing a 'real-life' Duke Energy PWR as the test bed. The focus for this step was to compare the key parameters of core reactivity and radial power distribution versus plant data. Following the core analysis, following a three cycle burn, a spent fuel pool analysis was done using information generated from NESTLE for the discharged bundles and was compared to Duke Energy spent fuel pool models. The KENO control module from SCALE was employed for this latter stage of the project. (authors)

  3. Hub-Filament Systems and Spiral Structures from Cloud to Core Scales

    NASA Astrophysics Data System (ADS)

    Galvan-Madrid, Roberto; Liu, Hauyu Baobab; Immer, Katharina; Juarez, Carmen; Palau, Aina

    2015-08-01

    We present evidence, from several separate observational studies, that molecular clouds and the clumps and cores within are (sometimes) arranged in a hub-filament morphology with spiral-like features. This arrangementoccurs at multiple scales: from the < 0.05 pc scales of low-mass star-forming cores, to the ~0.5 pc scales of clumps in massive star formation regions, to Giant Molecular Clouds. These structures have appeared in data of well known sources because of the increased sensitivy of new instruments like ALMA or the CSO SHARC-II, or after a detailed combination of single-dish and interferometer data. Reports of such structures may become more common in the near future. Presumably, these structures appear in systems that are dense enough to be prone to gravitational instabilities, and that have a non-negligible angularmomentum.

  4. Non-invasive methods to study flow and transport at the soil core and lysimeter scale

    NASA Astrophysics Data System (ADS)

    Vereecken, H.

    2004-12-01

    Non-invasive methods offer a great potential to study flow and transport processes at the core to the field and regional scale. In this contribution we will focus on the application of selected techniques such as MRI (Magnetic Resonance Imaging), X-Ray-Tomography (X-RT), MERIT (Magnetic Electrical Resistivity Imaging Technique), GPR (Ground Penetrating Radar) and Spectral Induced Polarisation (SIP) at the core to lysimeter scale. MRI is a powerful tool to derive local scale transport parameters. Based on the imaging of the 3-D temporal evolution of the spatial moments of a solute transport in a soil core, the local scale dispersivity of the soil can be derived. We also use MRI to image the root distribution inside a packed soil column. We employ the effect that the transverse relaxation time of water in the porous medium is considerably smaller than in the root tissue of rizinus communis. Different MRI pulse sequences were tested showing that the best contrast is obtainable by the strongly T2* weighted method CISS. X-RT provides information on the structure of the porous media. By parametrizing this structural information we may obtain an improved description of solute transport in undisturbed soil cores. GPR allows to map the spatial and temporal distribution of soil moisture in large undisturbed lysimeters. Combined with outflow data, this provides unique information to evaluate and improve mathematical models. New developments like MERIT are on their way which additionally exploits the magnetic information inherent in Electrical Resistivity Tomography-experiments to improve the spatial distribution of solute concentrations at lysimeter scale. SIP methods may be used to derive local scale pore size distribution and hydraulic conductivity. The single relaxation times, deduced from a measured phase spectrum either via multi-Cole-Cole-fits or as a whole relaxation time distribution, are a function of the relaxation length, which is connected to pore space

  5. Large-scale experiments on ex-vessel core melt behavior

    SciTech Connect

    Sappok, M.; Steinwarz, W.

    1997-12-01

    In the frame of European research activities on nuclear safety, experimental work on exvessel core melt behaviour under prototypic conditions is being performed. Spreading on various material surfaces and verification of relevant computer codes are the main tasks leading to an improvement of the design basis for corium retention systems. Especially the large-scale spreading test (1:6 with respect to the EPR spreading area) showed the advantageous characteristics of cast iron (GGG-40) as core catching substratum material. 4 refs., 11 figs.

  6. Improving measurement methods in rehabilitation: core concepts and recommendations for scale development.

    PubMed

    Velozo, Craig A; Seel, Ronald T; Magasi, Susan; Heinemann, Allen W; Romero, Sergio

    2012-08-01

    Validated measurement scales are essential to evaluating clinical outcomes and conducting meaningful and reliable research. The purpose of this article is to present the clinician and researcher with a contemporary 8-stage framework for measurement scale development based on a mixed-methods qualitative and quantitative approach. Core concepts related to item response theory are presented. Qualitative methods are described to conceptualize scale constructs; obtain patient, family, and other stakeholder perspectives; and develop item pools. Item response theory statistical methodologies are presented, including approaches for testing the assumptions of unidimensionality, local independence, monotonicity, and indices of model fit. Lastly, challenges faced by scale developers in implementing these methodologies are discussed. While rehabilitation research has recently started to apply mixed-methods qualitative and quantitative methodologies to scale development, these approaches show considerable promise in advancing rehabilitation measurement. PMID:22840881

  7. Magnetic braking, ambipolar diffusion, cloud cores, and star formation - Natural length scales and protostellar masses

    NASA Astrophysics Data System (ADS)

    Mouschovias, Telemachos Ch.

    1991-05-01

    Magnetic braking is essential for cloud contraction and star formation. Ambipolar diffusion is unavoidable in self-gravitating, magnetic clouds and leads to single-stage (as opposed to hierarchical) fragmentation (or core formation) and protostar formation. Magnetic forces dominate thermal-pressure and centrifugal forces over scales comparable to molecular cloud radii. Magnetic support of molecular clouds and the imperfect collisional coupling between charged and neutral particles introduce a critical magnetic length scale (λM,cr = 0.62υAτff) and an Alfvén length scale ((λA = πυAτni), respectively, in the problem which together with a critical thermal length scale (λT,cr = 1.09Caτff) explain naturally the formation of fragments (or cores) in otherwise quiescent clouds and determine the sizes and masses of these fragments during the subsequent stages of contraction. (The quantity υA is the Alfvén speed, τni the mean neutral-ion collision time, Ca the adiabatic speed of sound, and τff the free4all time scale.) Numerical calculations based on new adaptive-grid techniques follow the formation of fragments by ambipolar diffusion and their subsequent collapse up to an enhancement in central density above its initial equilibrium value by a factor ≃106 with excellent spatial resolution. The results confirm the existence and relevance of the three length scales and extend the analytical understanding of fragmentation and star formation derived from them. The ultimately bimodal opposition to gravity (by magnetic forces in the envelope and by thermal-pressure forces in the core) introduces a break in the slope of the log pn -log r profile. The relation Bc ∞ pkc between the magnetic field strength and the gas density in cloud cores holds with K = 0.4 - 0.5 even in the presence of ambipolar diffusion up to densities ˜109 cm-3 for a wide variety of clouds. The value K ≃ ½ is fairly typical. At the late stages of evolution, for example, at a central density

  8. Core-scale solute transport model selection using Monte Carlo analysis

    NASA Astrophysics Data System (ADS)

    Malama, Bwalya; Kuhlman, Kristopher L.; James, Scott C.

    2013-06-01

    Model applicability to core-scale solute transport is evaluated using breakthrough data from column experiments conducted with conservative tracers tritium (3H) and sodium-22 (22Na ), and the retarding solute uranium-232 (232U). The three models considered are single-porosity, double-porosity with single-rate mobile-immobile mass-exchange, and the multirate model, which is a deterministic model that admits the statistics of a random mobile-immobile mass-exchange rate coefficient. The experiments were conducted on intact Culebra Dolomite core samples. Previously, data were analyzed using single-porosity and double-porosity models although the Culebra Dolomite is known to possess multiple types and scales of porosity, and to exhibit multirate mobile-immobile-domain mass transfer characteristics at field scale. The data are reanalyzed here and null-space Monte Carlo analysis is used to facilitate objective model selection. Prediction (or residual) bias is adopted as a measure of the model structural error. The analysis clearly shows single-porosity and double-porosity models are structurally deficient, yielding late-time residual bias that grows with time. On the other hand, the multirate model yields unbiased predictions consistent with the late-time -5/2 slope diagnostic of multirate mass transfer. The analysis indicates the multirate model is better suited to describing core-scale solute breakthrough in the Culebra Dolomite than the other two models.

  9. cm-scale variations of crystal orientation fabric in cold Alpine ice core from Colle Gnifetti

    NASA Astrophysics Data System (ADS)

    Kerch, Johanna; Weikusat, Ilka; Eisen, Olaf; Wagenbach, Dietmar; Erhardt, Tobias

    2015-04-01

    Analysis of the microstructural parameters of ice has been an important part of ice core analyses so far mainly in polar cores in order to obtain information about physical processes (e.g. deformation, recrystallisation) on the micro- and macro-scale within an ice body. More recently the influence of impurities and climatic conditions during snow accumulation on these processes has come into focus. A deeper understanding of how palaeoclimate proxies interact with physical properties of the ice matrix bears relevance for palaeoclimatic interpretations, improved geophysical measurement techniques and the furthering of ice dynamical modeling. Variations in microstructural parameters e.g. crystal orientation fabric or grain size can be observed on a scale of hundreds and tens of metres but also on a centimetre scale. The underlying processes are not necessarily the same on all scales. Especially for the short-scale variations many questions remain unanswered. We present results from a study that aims to investigate following hypotheses: 1. Variations in grain size and fabric, i.e. strong changes of the orientation of ice crystals with respect to the vertical, occur on a centimetre scale and can be observed in all depths of an ice core. 2. Palaeoclimate proxies like dust and impurities have an impact on the microstructural processes and thus are inducing the observed short-scale variations in grain size and fabric. 3. The interaction of proxies with the ice matrix leads to depth intervals that show correlating behaviour as well as ranges with anticorrelation between microstructural parameters and palaeoclimatic proxies. The respective processes need to be identified. Fabric Analyser measurements were conducted on more than 80 samples (total of 8 m) from different depth ranges of a cold Alpine ice core (72 m length) drilled in 2013 at Colle Gnifetti, Switzerland/Italy. Results were obtained by automatic image processing, providing estimates for grain size distributions

  10. Radial And Lateral Topographic Scales of the Inner-Core Boundary

    NASA Astrophysics Data System (ADS)

    Zheng, Y.; Cormier, V. F.; Fehler, M. C.

    2012-12-01

    Strong seismic evidence suggests that the inner core boundary region is dynamic. First, the strong PKP-df coda wave train in the previous time-lapse studies using earthquake doublets cannot be explained by simple rotation of the anisotropic inner core. Second, the observed PKiKP reflection amplitude from nuclear tests does not follow the prediction of a simple spherical model such as the PREM or IASP91. Third, observed amplitude and the traveltime of the PKP C-diff arrival favor different but inconsistent models (PREM-like linear gradient and IASP91-like no gradient, respectively) for the lowermost outer core. Fourth, we observed a seismic phase that had not been reported in the literature in the range of 150-153 degrees, which is about 2.0 seconds after the PKP-df and it has slightly positive slowness deviation compared to the PKIKP-df. Seismic migration showed that this arrival is associated with scattering objects above the turning depth of the PKIKP-df, close to the inner-core boundary. Using an elastic boundary element method, which takes into account of the fluid-solid boundary condition, we simulated high frequency (> 1 Hz) wave propagation and scattering in the inner core boundary region. We propose the presence of inner core topography as a plausible mechanism to explain all these observations. Our preliminary results by modeling the PKiKP amplitude showed that the previously proposed "mosaic structure" of the inner core could be well explained by inner core topography, with horizontal scale ~ 10km and vertical scale ~2km. In addition, for a fluid-solid boundary, topography can generate a strong Scholte wave, which is an interface wave (like the Rayleigh wave) whose amplitude decays exponentially away from the boundary. The Scholte wave can leak energy out of the C-diff wave therefore reducing the C-diff amplitude. Modeling the PKiKP, PKP-df coda and PKP C-diff allows us to place vertical and horizontal topographic bounds for the inner-core boundary.

  11. Accelerated gravity testing of aquitard core permeability and implications at formation and regional scale

    NASA Astrophysics Data System (ADS)

    Timms, W. A.; Crane, R.; Anderson, D. J.; Bouzalakos, S.; Whelan, M.; McGeeney, D.; Rahman, P. F.; Guinea, A.; Acworth, R. I.

    2015-03-01

    Evaluating the possibility of leakage through low permeability geological strata is critically important for sustainable water supplies, the extraction of fuels from strata such as coal beds, and the confinement of waste within the earth. The current work demonstrates that relatively rapid and reliable hydraulic conductivity (K) measurement of aquitard cores using accelerated gravity can inform and constrain larger scale assessments of hydraulic connectivity. Steady state fluid velocity through a low K porous sample is linearly related to accelerated gravity (g-level) in a centrifuge permeameter (CP) unless consolidation or geochemical reactions occur. The CP module was custom designed to fit a standard 2 m diameter geotechnical centrifuge (550 g maximum) with a capacity for sample dimensions of 30 to 100 mm diameter and 30 to 200 mm in length, and a maximum total stress of ~2 MPa at the base of the core. Formation fluids were used as influent to limit any shrink-swell phenomena which may alter the permeability. Vertical hydraulic conductivity (Kv) results from CP testing of cores from three sites within the same regional clayey silt formation varied (10-7 to 10-9 m s-1, n = 14). Results at one of these sites (1.1 × 10-10 to 3.5 × 10-9 m s-1, n = 5) that were obtained in < 24 h were similar to in situ Kv values (3 × 10-9 m s-1) from pore pressure responses over several weeks within a 30 m clayey sequence. Core scale and in situ Kv results were compared with vertical connectivity within a regional flow model, and considered in the context of heterogeneity and preferential flow paths at site and formation scale. More reliable assessments of leakage and solute transport though aquitards over multi-decadal timescales can be achieved by accelerated core testing together with advanced geostatistical and numerical methods.

  12. Harnessing Petaflop-Scale Multi-Core Supercomputing for Problems in Space Science

    NASA Astrophysics Data System (ADS)

    Albright, B. J.; Yin, L.; Bowers, K. J.; Daughton, W.; Bergen, B.; Kwan, T. J.

    2008-12-01

    The particle-in-cell kinetic plasma code VPIC has been migrated successfully to the world's fastest supercomputer, Roadrunner, a hybrid multi-core platform built by IBM for the Los Alamos National Laboratory. How this was achieved will be described and examples of state-of-the-art calculations in space science, in particular, the study of magnetic reconnection, will be presented. With VPIC on Roadrunner, we have performed, for the first time, plasma PIC calculations with over one trillion particles, >100× larger than calculations considered "heroic" by community standards. This allows examination of physics at unprecedented scale and fidelity. Roadrunner is an example of an emerging paradigm in supercomputing: the trend toward multi-core systems with deep hierarchies and where memory bandwidth optimization is vital to achieving high performance. Getting VPIC to perform well on such systems is a formidable challenge: the core algorithm is memory bandwidth limited with low compute-to-data ratio and requires random access to memory in its inner loop. That we were able to get VPIC to perform and scale well, achieving >0.374 Pflop/s and linear weak scaling on real physics problems on up to the full 12240-core Roadrunner machine, bodes well for harnessing these machines for our community's needs in the future. Many of the design considerations encountered commute to other multi-core and accelerated (e.g., via GPU) platforms and we modified VPIC with flexibility in mind. These will be summarized and strategies for how one might adapt a code for such platforms will be shared. Work performed under the auspices of the U.S. DOE by the LANS LLC Los Alamos National Laboratory. Dr. Bowers is a LANL Guest Scientist; he is presently at D. E. Shaw Research LLC, 120 W 45th Street, 39th Floor, New York, NY 10036.

  13. Pre-Stressing Micron-Scale Aluminum Core-Shell Particles to Improve Reactivity

    NASA Astrophysics Data System (ADS)

    Levitas, Valery I.; McCollum, Jena; Pantoya, Michelle

    2015-01-01

    The main direction in increasing reactivity of aluminum (Al) particles for energetic applications is reduction in their size down to nanoscale. However, Al nanoparticles are 30-50 times more expensive than micron scale particles and possess safety and environmental issues. Here, we improved reactivity of Al micron scale particles by synthesizing pre-stressed core-shell structures. Al particles were annealed and quenched to induce compressive stresses in the alumina passivation shell surrounding Al core. This thermal treatment was designed based on predictions of the melt-dispersion mechanism (MDM); a theory describing Al particle reaction under high heating rate. For all anneal treatment temperatures, experimental flame propagation rates for Al combined with nanoscale copper oxide (CuO) are in quantitative agreement with the theoretical predictions based on the MDM. The best treatment increases flame rate by 36% and achieves 68% of that for the best Al nanoparticles.

  14. Pre-Stressing Micron-Scale Aluminum Core-Shell Particles to Improve Reactivity

    PubMed Central

    Levitas, Valery I.; McCollum, Jena; Pantoya, Michelle

    2015-01-01

    The main direction in increasing reactivity of aluminum (Al) particles for energetic applications is reduction in their size down to nanoscale. However, Al nanoparticles are 30–50 times more expensive than micron scale particles and possess safety and environmental issues. Here, we improved reactivity of Al micron scale particles by synthesizing pre-stressed core-shell structures. Al particles were annealed and quenched to induce compressive stresses in the alumina passivation shell surrounding Al core. This thermal treatment was designed based on predictions of the melt-dispersion mechanism (MDM); a theory describing Al particle reaction under high heating rate. For all anneal treatment temperatures, experimental flame propagation rates for Al combined with nanoscale copper oxide (CuO) are in quantitative agreement with the theoretical predictions based on the MDM. The best treatment increases flame rate by 36% and achieves 68% of that for the best Al nanoparticles. PMID:25597747

  15. Core and peripheral criteria of video game addiction in the game addiction scale for adolescents.

    PubMed

    Brunborg, Geir Scott; Hanss, Daniel; Mentzoni, Rune Aune; Pallesen, Ståle

    2015-05-01

    Assessment of video game addiction often involves measurement of peripheral criteria that indicate high engagement with games, and core criteria that indicate problematic use of games. A survey of the Norwegian population aged 16-74 years (N=10,081, response rate 43.6%) was carried out in 2013, which included the Gaming Addiction Scale for Adolescents (GAS). Confirmatory factor analysis showed that a two-factor structure, which separated peripheral criteria from core criteria, fitted the data better (CFI=0.963; RMSEA=0.058) compared to the original one-factor solution where all items are determined to load only on one factor (CFI=0.905, RMSEA=0.089). This was also found when we analyzed men aged ≤33 years, men aged >33 years, women aged ≤33 years, and women aged >33 years separately. This indicates that the GAS measures both engagement and problems related to video games. Multi-group measurement invariance testing showed that the factor structure was valid in all four groups (configural invariance) for the two-factor structure but not for the one-factor structure. A novel approach to categorization of problem gamers and addicted gamers where only the core criteria items are used (the CORE 4 approach) was compared to the approach where all items are included (the GAS 7 approach). The current results suggest that the CORE 4 approach might be more appropriate for classification of problem gamers and addicted gamers compared to the GAS 7 approach.

  16. Core and peripheral criteria of video game addiction in the game addiction scale for adolescents.

    PubMed

    Brunborg, Geir Scott; Hanss, Daniel; Mentzoni, Rune Aune; Pallesen, Ståle

    2015-05-01

    Assessment of video game addiction often involves measurement of peripheral criteria that indicate high engagement with games, and core criteria that indicate problematic use of games. A survey of the Norwegian population aged 16-74 years (N=10,081, response rate 43.6%) was carried out in 2013, which included the Gaming Addiction Scale for Adolescents (GAS). Confirmatory factor analysis showed that a two-factor structure, which separated peripheral criteria from core criteria, fitted the data better (CFI=0.963; RMSEA=0.058) compared to the original one-factor solution where all items are determined to load only on one factor (CFI=0.905, RMSEA=0.089). This was also found when we analyzed men aged ≤33 years, men aged >33 years, women aged ≤33 years, and women aged >33 years separately. This indicates that the GAS measures both engagement and problems related to video games. Multi-group measurement invariance testing showed that the factor structure was valid in all four groups (configural invariance) for the two-factor structure but not for the one-factor structure. A novel approach to categorization of problem gamers and addicted gamers where only the core criteria items are used (the CORE 4 approach) was compared to the approach where all items are included (the GAS 7 approach). The current results suggest that the CORE 4 approach might be more appropriate for classification of problem gamers and addicted gamers compared to the GAS 7 approach. PMID:25826043

  17. Crystallization of ion clouds in octupole traps: Structural transitions, core melting, and scaling laws

    SciTech Connect

    Calvo, F.; Champenois, C.; Yurtsever, E.

    2009-12-15

    The stable structures and melting properties of ion clouds in isotropic octupole traps are investigated using a combination of semianalytical and numerical models, with a particular emphasis at finite-size scaling effects. Small-size clouds are found to be hollow and arranged in shells corresponding approximately to the solutions of the Thomson problem. The shell structure is lost in clusters containing more than a few thousands of ions, the inner parts of the cloud becoming soft and amorphous. While melting is triggered in the core shells, the melting temperature follows the rule expected for three-dimensional dense particles, with a depression scaling linearly with the inverse radius.

  18. Generic phytosanitary irradiation treatments

    NASA Astrophysics Data System (ADS)

    Hallman, Guy J.

    2012-07-01

    The history of the development of generic phytosanitary irradiation (PI) treatments is discussed beginning with its initial proposal in 1986. Generic PI treatments in use today are 150 Gy for all hosts of Tephritidae, 250 Gy for all arthropods on mango and papaya shipped from Australia to New Zealand, 300 Gy for all arthropods on mango shipped from Australia to Malaysia, 350 Gy for all arthropods on lychee shipped from Australia to New Zealand and 400 Gy for all hosts of insects other than pupae and adult Lepidoptera shipped to the United States. Efforts to develop additional generic PI treatments and reduce the dose for the 400 Gy treatment are ongoing with a broad based 5-year, 12-nation cooperative research project coordinated by the joint Food and Agricultural Organization/International Atomic Energy Agency Program on Nuclear Techniques in Food and Agriculture. Key groups identified for further development of generic PI treatments are Lepidoptera (eggs and larvae), mealybugs and scale insects. A dose of 250 Gy may suffice for these three groups plus others, such as thrips, weevils and whiteflies.

  19. TALDICE-1 age scale of the Talos Dome deep ice core, East Antarctica

    NASA Astrophysics Data System (ADS)

    Buiron, D.; Chappellaz, J.; Stenni, B.; Frezzotti, M.; Baumgartner, M.; Capron, E.; Landais, A.; Lemieux-Dudon, B.; Masson-Delmotte, V.; Montagnat, M.; Parrenin, F.; Schilt, A.

    2011-01-01

    A new deep ice core drilling program, TALDICE, has been successfully handled by a European team at Talos Dome, in the Ross Sea sector of East Antarctica, down to 1620 m depth. Using stratigraphic markers and a new inverse method, we produce the first official chronology of the ice core, called TALDICE-1. We show that it notably improves an a priori chronology resulting from a one-dimensional ice flow model. It is in agreement with a posteriori controls of the resulting accumulation rate and thinning function along the core. An absolute uncertainty of only 300 yr is obtained over the course of the last deglaciation. This uncertainty remains lower than 600 yr over Marine Isotope Stage 3, back to 50 kyr BP. The phasing of the TALDICE ice core climate record with respect to the central East Antarctic plateau and Greenland records can thus be determined with a precision allowing for a discussion of the mechanisms at work at sub-millennial time scales.

  20. TALDICE-1 age scale of the Talos Dome deep ice core, East Antarctica

    NASA Astrophysics Data System (ADS)

    Buiron, D.; Chappellaz, J.; Stenni, B.; Frezzotti, M.; Baumgartner, M.; Capron, E.; Landais, A.; Lemieux-Dudon, B.; Masson-Delmotte, V.; Montagnat, M.; Parrenin, F.; Schilt, A.

    2010-09-01

    A new deep ice core drilling, TALDICE, has been successfully handled by a European team at Talos Dome, in the Ross Sea sector of East Antarctica, down to 1620 m depth. Using stratigraphic markers and a new inverse method, we produce the first official chronology of the ice core, called TALDICE-1. We show that it notably improves an a priori chronology resulting from a one-dimensional ice flow model, and that it is in agreement with a posteriori controls of the resulting accumulation rate and thinning function along the core. An absolute uncertainty of only 300 yr is obtained in the course of the last deglaciation. This uncertainty remains lower than 600 yr over Marine Isotope Stage 3, back to 50 kyr BP. The phasing of the TALDICE ice core climate record with respect to the central East Antarctic plateau and Greenland records can thus be determined with a precision allowing for a discussion of the mechanisms at work at sub-millennial time scales.

  1. Bipolar ice core records of millennial scale climate variability : an overview of recent findings (Invited)

    NASA Astrophysics Data System (ADS)

    Masson-Delmotte, V.; Landais, A.

    2013-12-01

    Greenland and Antarctic ice cores offer high resolution records of the imprints of millennial scale climate variability on polar climate, aerosol deposition, and atmospheric composition (Wolff et al, QSR, 2010). Improved chronologies and spatial coverage provide new data against which the mechanisms involved in millennial variability and simulated by climate models can be tested. We will first discuss the bipolar sequence of events based on the new AICC2012 chronology, during the last climatic cycle (Veres et al, Clim. Past, 2013; Bazin et al, Clim. Past, 2013). The matrix of ice cores allows to investigate regional differences in the cross-Greenland fingerprints of Dansgaard-Oeschger events (Guillevic et al, Clim. Past, 2013) and the circum-Antarctic signature of their Antarctic Isotopic Maxima counterpart (Buiron et al, QSR, 2012). While Heinrich events have long remained difficult to identify in ice core records, a step change in atmospheric CO2 concentrations has been identified during Heinrich 4 (Ahn et al, GRL, 2012), challenging the gradual CO2 emissions expected from the classical bipolar see-saw explanation. High resolution Antarctic data also reveal centennial to millennial variability during interglacial periods and glacial inceptions which bears similarities with glacial Antarctic Isotopic Maxima, questioning the source and amplifiers of glacial millennial variability. New investigations of the magnitude and recurrence of millennial variability based on multiple long Antarctic ice core records are expected to provide further hints on the interplay between mean climatic states and this millennial variability.

  2. Time-scale synchronization among EDC, EDML and TD ice cores (Antarctica) by volcanic stratigraphies.

    NASA Astrophysics Data System (ADS)

    Severi, Mirko; Becagli, Silvia; Castellano, Emiliano; Manganelli, Desirè; Traversi, Rita; Udisti, Roberto

    2010-05-01

    In the framework of the TALDICE project (TALos Dome Ice CorE), a deep ice core has been drilled on a peripheral dome of East Antarctica. The perforation at Talos Dome (159°11' E 72°49'S 2315 m a.s.l.) reached 1620 m during the 2007-2008 austral summer, covering a period of about 250 kyr. A reliable high-resolution synchronisation of the TD volcanic stratigraphy with the well dated EPICA DC and EPICA DML ice cores is a basic tool for the construction of a reliable timescale and will be a powerful tool to discover whether related climatic events in different sectors of the Antarctic continent occurred at the same time or if there was an offset for the same event in different sites. In this optic, a FIC (Fast Ion Chromatography) system (coupled to a CFA - Continuous Flow Analysis setup) was used to reconstruct the paleo-volcanic record at this site as was already done for the two EPICA cores with very high resolution (ranging from less than 1 to about 3.5 cm per sample). Here we report the results of the synchronisation among the TD and the EDC and EDML ice-cores via individuation of synchronous volcanic events for the last 40 kyr. Several isochronous volcanic events were identified by the comparison of the volcanic stratigraphies and these signatures will be an helpful tool in carrying on a fine-tuning of the pure glaciological model of the TD timescale. Low resolution accumulation rates at TD site for the last deglaciation were then derived from the comparison of couples of volcanic events using the EDC3 agescale. These accumulation rates were then compared to those derived via glaciological modelling showing a very good agreement. This kind of volcanic synchronisation was already carried out for the two EPICA ice cores and for the Vostok and EPICA-DC cores. Once this comparison will be fully available, it will be possible to synchronize these 4 archives and to extend the peak to peak comparison to other Antarctic ice cores. Furthermore the comparison of several

  3. Mode-converters for rectangular-core fiber amplifiers to achieve diffraction-limited power scaling.

    PubMed

    Sridharan, Arun Kumar; Pax, Paul H; Heebner, John E; Drachenberg, Derrek R; Armstrong, J Paul; Dawson, Jay W

    2012-12-17

    A rectangular-core (ribbon) fiber that guides and amplifies a single higher-order-mode (HOM) can potentially scale to much higher average powers than what is possible in traditional circular-core large-mode-area fibers. Such an amplifier would require mode-conversion at the input to enable interfacing with seed sources that typically output TEM(00) mode radiation and at the output to generate diffraction-limited radiation for end-user applications. We present the first simulation and experimental results of a mode conversion technique that uses two diffractive-optic-elements in conjugate Fourier planes to convert a diffraction limited TEM(00) mode to the HOM of a ribbon fiber. Mode-conversion-efficiency is approximately 84% and can theoretically approach 100%. We also demonstrate a mode-converter system that converts a single HOM of a ribbon fiber back to a diffraction-limited TEM(00) mode. Conversion efficiency is a record 80.5%.

  4. Core and Peripheral Criteria of Video Game Addiction in the Game Addiction Scale for Adolescents

    PubMed Central

    Hanss, Daniel; Mentzoni, Rune Aune; Pallesen, Ståle

    2015-01-01

    Abstract Assessment of video game addiction often involves measurement of peripheral criteria that indicate high engagement with games, and core criteria that indicate problematic use of games. A survey of the Norwegian population aged 16–74 years (N=10,081, response rate 43.6%) was carried out in 2013, which included the Gaming Addiction Scale for Adolescents (GAS). Confirmatory factor analysis showed that a two-factor structure, which separated peripheral criteria from core criteria, fitted the data better (CFI=0.963; RMSEA=0.058) compared to the original one-factor solution where all items are determined to load only on one factor (CFI=0.905, RMSEA=0.089). This was also found when we analyzed men aged ≤33 years, men aged >33 years, women aged ≤33 years, and women aged >33 years separately. This indicates that the GAS measures both engagement and problems related to video games. Multi-group measurement invariance testing showed that the factor structure was valid in all four groups (configural invariance) for the two-factor structure but not for the one-factor structure. A novel approach to categorization of problem gamers and addicted gamers where only the core criteria items are used (the CORE 4 approach) was compared to the approach where all items are included (the GAS 7 approach). The current results suggest that the CORE 4 approach might be more appropriate for classification of problem gamers and addicted gamers compared to the GAS 7 approach. PMID:25826043

  5. Image-guided Coring for Large-scale Studies in Molecular Pathology

    PubMed Central

    Montaser-Kouhsari, Laleh; Knoblauch, Nicholas W.; Oh, Eun-Yeong; Baker, Gabrielle; Christensen, Stephen; Hazra, Aditi; Tamimi, Rulla M.

    2016-01-01

    Sampling of formalin-fixed paraffin-embedded (FFPE) tissue blocks is a critical initial step in molecular pathology. Image-guided coring (IGC) is a new method for using digital pathology images to guide tissue block coring for molecular analyses. The goal of our study is to evaluate the use of IGC for both tissue-based and nucleic acid–based projects in molecular pathology. First, we used IGC to construct a tissue microarray (TMA); second, we used IGC for FFPE block sampling followed by RNA extraction; and third, we assessed the correlation between nuclear counts quantitated from the IGC images and RNA yields. We used IGC to construct a TMA containing 198 normal and breast cancer cores. Histopathologic analysis showed high accuracy for obtaining tumor and normal breast tissue. Next, we used IGC to obtain normal and tumor breast samples before RNA extraction. We selected a random subset of tumor and normal samples to perform computational image analysis to quantify nuclear density, and we built regression models to estimate RNA yields from nuclear count, age of the block, and core diameter. Number of nuclei and core diameter were the strongest predictors of RNA yields in both normal and tumor tissue. IGC is an effective method for sampling FFPE tissue blocks for TMA construction and nucleic acid extraction. We identify significant associations between quantitative nuclear counts obtained from IGC images and RNA yields, suggesting that the integration of computational image analysis with IGC may be an effective approach for tumor sampling in large-scale molecular studies. PMID:26186251

  6. Comparison of Prestellar Core Elongations and Large-scale Molecular Cloud Structures in the Lupus I Region

    NASA Astrophysics Data System (ADS)

    Poidevin, Frédérick; Ade, Peter A. R.; Angile, Francesco E.; Benton, Steven J.; Chapin, Edward L.; Devlin, Mark J.; Fissel, Laura M.; Fukui, Yasuo; Gandilo, Natalie N.; Gundersen, Joshua O.; Hargrave, Peter C.; Klein, Jeffrey; Korotkov, Andrei L.; Matthews, Tristan G.; Moncelsi, Lorenzo; Mroczkowski, Tony K.; Netterfield, Calvin B.; Novak, Giles; Nutter, David; Olmi, Luca; Pascale, Enzo; Savini, Giorgio; Scott, Douglas; Shariff, Jamil A.; Diego Soler, Juan; Tachihara, Kengo; Thomas, Nicholas E.; Truch, Matthew D. P.; Tucker, Carole E.; Tucker, Gregory S.; Ward-Thompson, Derek

    2014-08-01

    Turbulence and magnetic fields are expected to be important for regulating molecular cloud formation and evolution. However, their effects on sub-parsec to 100 parsec scales, leading to the formation of starless cores, are not well understood. We investigate the prestellar core structure morphologies obtained from analysis of the Herschel-SPIRE 350 μm maps of the Lupus I cloud. This distribution is first compared on a statistical basis to the large-scale shape of the main filament. We find the distribution of the elongation position angle of the cores to be consistent with a random distribution, which means no specific orientation of the morphology of the cores is observed with respect to the mean orientation of the large-scale filament in Lupus I, nor relative to a large-scale bent filament model. This distribution is also compared to the mean orientation of the large-scale magnetic fields probed at 350 μm with the Balloon-borne Large Aperture Telescope for Polarimetry during its 2010 campaign. Here again we do not find any correlation between the core morphology distribution and the average orientation of the magnetic fields on parsec scales. Our main conclusion is that the local filament dynamics—including secondary filaments that often run orthogonally to the primary filament—and possibly small-scale variations in the local magnetic field direction, could be the dominant factors for explaining the final orientation of each core.

  7. Comparison of prestellar core elongations and large-scale molecular cloud structures in the Lupus I region

    SciTech Connect

    Poidevin, Frédérick; Ade, Peter A. R.; Hargrave, Peter C.; Nutter, David; Angile, Francesco E.; Devlin, Mark J.; Klein, Jeffrey; Benton, Steven J.; Netterfield, Calvin B.; Chapin, Edward L.; Fissel, Laura M.; Gandilo, Natalie N.; Fukui, Yasuo; Gundersen, Joshua O.; Korotkov, Andrei L.; Matthews, Tristan G.; Novak, Giles; Moncelsi, Lorenzo; Mroczkowski, Tony K.; Olmi, Luca; and others

    2014-08-10

    Turbulence and magnetic fields are expected to be important for regulating molecular cloud formation and evolution. However, their effects on sub-parsec to 100 parsec scales, leading to the formation of starless cores, are not well understood. We investigate the prestellar core structure morphologies obtained from analysis of the Herschel-SPIRE 350 μm maps of the Lupus I cloud. This distribution is first compared on a statistical basis to the large-scale shape of the main filament. We find the distribution of the elongation position angle of the cores to be consistent with a random distribution, which means no specific orientation of the morphology of the cores is observed with respect to the mean orientation of the large-scale filament in Lupus I, nor relative to a large-scale bent filament model. This distribution is also compared to the mean orientation of the large-scale magnetic fields probed at 350 μm with the Balloon-borne Large Aperture Telescope for Polarimetry during its 2010 campaign. Here again we do not find any correlation between the core morphology distribution and the average orientation of the magnetic fields on parsec scales. Our main conclusion is that the local filament dynamics—including secondary filaments that often run orthogonally to the primary filament—and possibly small-scale variations in the local magnetic field direction, could be the dominant factors for explaining the final orientation of each core.

  8. Small-scale disturbances in the stratigraphy of ice cores: observations and numerical model simulations

    NASA Astrophysics Data System (ADS)

    Jansen, Daniela; LLorens, Maria-Gema; Westhoff, Julien; Steinbach, Florian; Kipfstuhl, Sepp; Bons, Paul D.; Griera, Albert; Eichler, Jan; Weikusat, Ilka

    2016-04-01

    Visual stratigraphy of ice cores from Greenland as well as Antarctica revealed folding on a cm scale, with fold amplitudes varying from less than 1 cm to a few decimetres. Stratigraphy bands are visualized by an indirect light source scattering on surfaces inside the ice, mainly particles and air bubbles / hydrates. Due to their potential influence on the integrity of the climatic record, folds have been subject to modelling studies, however, the initial formation of the disturbances is not fully understood. In this study we present a detailed analysis of the visible folds from the NEEM ice core from Greenland and the EDML ice core from Antarctica, discuss their characteristics and frequency and present examples of typical fold structures. We also analyse the structures with regard to the deformation boundary conditions under which they formed. In case of the NEEM core the structures evolve from gentle waves at about 1500 m to overturned z-folds with increasing depth. Occasionally, the folding causes significant thickening of layers. Their similar-fold shape indicates that they are passive features and are probably not initiated by rheology differences between alternating layers. Layering is heavily disturbed and tracing of single layers is no longer possible below a depth of 2160 m. C-axes orientation distributions for the corresponding core sections were analysed where available in addition to visual stratigraphy. The data show axial-plane parallel strings of grains with c-axis orientations that deviate from that of the matrix, which shows a single-maximum fabric at the depth where the folding occurs. In case of the EDML ice cores the folding starts at a depth of about 1700 m and show very similar characteristics as found in the NEEM core. Numerical modelling of crystal viscoplasticity deformation and dynamic recrystallisation was used to improve the understanding of the formation of the observed structures during deformation. The modelling reproduces the

  9. Infrared length scale and extrapolations for the no-core shell model

    NASA Astrophysics Data System (ADS)

    Wendt, K. A.; Forssén, C.; Papenbrock, T.; Sääf, D.

    2015-06-01

    We precisely determine the infrared (IR) length scale of the no-core shell model (NCSM). In the NCSM, the A -body Hilbert space is truncated by the total energy, and the IR length can be determined by equating the intrinsic kinetic energy of A nucleons in the NCSM space to that of A nucleons in a 3 (A -1 ) -dimensional hyper-radial well with a Dirichlet boundary condition for the hyper radius. We demonstrate that this procedure indeed yields a very precise IR length by performing large-scale NCSM calculations for 6Li. We apply our result and perform accurate IR extrapolations for bound states of 4He,6He,6Li , and 7Li . We also attempt to extrapolate NCSM results for 10B and 16O with bare interactions from chiral effective field theory over tens of MeV.

  10. Infrared length scale and extrapolations for the no-core shell model

    DOE PAGESBeta

    Wendt, K. A.; Forssén, C.; Papenbrock, T.; Sääf, D.

    2015-06-03

    In this paper, we precisely determine the infrared (IR) length scale of the no-core shell model (NCSM). In the NCSM, the A-body Hilbert space is truncated by the total energy, and the IR length can be determined by equating the intrinsic kinetic energy of A nucleons in the NCSM space to that of A nucleons in a 3(A-1)-dimensional hyper-radial well with a Dirichlet boundary condition for the hyper radius. We demonstrate that this procedure indeed yields a very precise IR length by performing large-scale NCSM calculations for 6Li. We apply our result and perform accurate IR extrapolations for bound statesmore » of 4He, 6He, 6Li, and 7Li. Finally, we also attempt to extrapolate NCSM results for 10B and 16O with bare interactions from chiral effective field theory over tens of MeV.« less

  11. Accelerated gravity testing of aquitard core permeability and implications at formation and regional scale

    NASA Astrophysics Data System (ADS)

    Timms, W. A.; Crane, R.; Anderson, D. J.; Bouzalakos, S.; Whelan, M.; McGeeney, D.; Rahman, P. F.; Acworth, R. I.

    2016-01-01

    Evaluating the possibility of leakage through low-permeability geological strata is critically important for sustainable water supplies, the extraction of fuels from coal and other strata, and the confinement of waste within the earth. The current work demonstrates that relatively rapid and realistic vertical hydraulic conductivity (Kv) measurements of aquitard cores using accelerated gravity can constrain and compliment larger-scale assessments of hydraulic connectivity. Steady-state fluid velocity through a low-K porous sample is linearly related to accelerated gravity (g level) in a centrifuge permeameter (CP) unless consolidation or geochemical reactions occur. A CP module was custom designed to fit a standard 2 m diameter geotechnical centrifuge (550 g maximum) with a capacity for sample dimensions up to 100 mm diameter and 200 mm length, and a total stress of ˜ 2 MPa at the base of the core. Formation fluids were used as influent to limit any shrink-swell phenomena, which may alter the permeability. Kv results from CP testing of minimally disturbed cores from three sites within a clayey-silt formation varied from 10-10 to 10-7 m s-1 (number of samples, n = 18). Additional tests were focussed on the Cattle Lane (CL) site, where Kv within the 99 % confidence interval (n = 9) was 1.1 × 10-9 to 2.0 × 10-9 m s-1. These Kv results were very similar to an independent in situ Kv method based on pore pressure propagation though the sequence. However, there was less certainty at two other core sites due to limited and variable Kv data. Blind standard 1 g column tests underestimated Kv compared to CP and in situ Kv data, possibly due to deionised water interactions with clay, and were more time-consuming than CP tests. Our Kv results were compared with the set-up of a flow model for the region, and considered in the context of heterogeneity and preferential flow paths at site and

  12. Diverted Tokamak Carbon Screening: Scaling with Machine Size and Consequences to Core Contamination

    SciTech Connect

    J.D. Strachan; G. Corrigan; A. Kallenbach; G.F. Matthews; H. Meister; R. Neu; V. Rohde; J. Spence

    2004-01-23

    Plasma impurity content depends upon the impurity sources, fueling efficiency, and confinement. In JET [Joint European Torus], carbon is the primary impurity, and its fueling efficiency has been studied using methane gas injection and modeled with the SOL [scrape-off layer] codes: DIVIMP and EDGE2D. In this paper, EDGE2D modeling of similar AUG [ASDEX-Upgrade] experiments and projections to ITER are described. The parameters have been identified which govern the size scaling of carbon screening. Size scaling is complex. For carbon injected from the main chamber, the important factors include: the SOL temperature, the magnitude of the thermal force at the divertor entrance, and the parallel distance to the divertor. For carbon injected at the strike points, the intersection of the carbon ionization region with the region of strong thermal force determines the carbon fueling efficiency ITER projects to have much better carbon screening than JET. The ITER SOL is hotter so that main chamber carbon is ionized further from the separatrix making the calculated carbon fueling efficiency lower. Also, the carbon originating near the strike point has less chance of escaping the divertor by factors of about 100. The carbon sputtering is projected to be larger by similar factors, making the projected ITER core contamination similar to JET. However, that result is based upon the assumption that the wall materials have similar composition and behavior as observed on JET. A general result is that the core contamination at fixed total sputtering rate and core impurity confinement increases when the fraction of carbon ionized in the main chamber SOL increases, and decreases for larger machine size and higher density operation.

  13. Disentangling the dynamic core: a research program for a neurodynamics at the large-scale.

    PubMed

    Le Van Quyen, Michel

    2003-01-01

    My purpose in this paper is to sketch a research direction based on Francisco Varela's pioneering work in neurodynamics (see also Rudrauf et al. 2003, in this issue). Very early on he argued that the internal coherence of every mental-cognitive state lies in the global self-organization of the brain activities at the large-scale, constituting a fundamental pole of integration called here a "dynamic core". Recent neuroimaging evidence appears to broadly support this hypothesis and suggests that a global brain dynamics emerges at the large scale level from the cooperative interactions among widely distributed neuronal populations. Despite a growing body of evidence supporting this view, our understanding of these large-scale brain processes remains hampered by the lack of a theoretical language for expressing these complex behaviors in dynamical terms. In this paper, I propose a rough cartography of a comprehensive approach that offers a conceptual and mathematical framework to analyze spatio-temporal large-scale brain phenomena. I emphasize how these nonlinear methods can be applied, what property might be inferred from neuronal signals, and where one might productively proceed for the future. This paper is dedicated, with respect and affection, to the memory of Francisco Varela.

  14. Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects.

    PubMed

    Tang, Fang; Zhou, Rui; Cheng, Zeneng; Yang, Guoping; Chen, Aiqiao; Liu, Zhi; Tan, Hongyi; Yang, Shuang; Li, Sanwang; Mu, Lingli; Yu, Peng

    2016-01-01

    The aim of this study was to apply the reference-scaled average bioequivalence (RSABE) approach to evaluate the bioequivalence of 2 formulations of agomelatine, and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects. This was performed in a single-dose, randomized-sequence, open-label, four-way crossover study with a one-day washout period between doses. Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation. The formulations were considered bioequivalent if 90% confidence intervals (CIs) for the log-transformed ratios and ratio of geometric means (GMR) of AUC and C max of agomelatine were within the predetermined bioequivalence range based on RSABE method. Results showed that both of the 90% CIs for the log-transformed ratios of AUC and C max of 7-desmethyl-agomelatine and 3-hydroxy-agomelatine were within the predetermined bioequivalence range. The 90% CIs for natural log-transformed ratios of C max, AUC0-t and AUC0-∞ of agomelatine (104.42-139.86, 101.33-123.83 and 97.90-117.94) were within the RSABE acceptance limits, and 3-hydroxy-agomelatine (105.55-123.03, 101.95-109.10 and 101.72-108.70) and 7-desmethyl-agomelatine (104.50-125.23, 102.36-111.50 and 101.62-110.64) were within the FDA bioequivalence definition intervals (0.80-1.25 for AUC and 0.75-1.33 for C max). The RSABE approach was successful in evaluating the bioequivalence of these two formulations.

  15. Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects.

    PubMed

    Tang, Fang; Zhou, Rui; Cheng, Zeneng; Yang, Guoping; Chen, Aiqiao; Liu, Zhi; Tan, Hongyi; Yang, Shuang; Li, Sanwang; Mu, Lingli; Yu, Peng

    2016-01-01

    The aim of this study was to apply the reference-scaled average bioequivalence (RSABE) approach to evaluate the bioequivalence of 2 formulations of agomelatine, and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects. This was performed in a single-dose, randomized-sequence, open-label, four-way crossover study with a one-day washout period between doses. Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation. The formulations were considered bioequivalent if 90% confidence intervals (CIs) for the log-transformed ratios and ratio of geometric means (GMR) of AUC and C max of agomelatine were within the predetermined bioequivalence range based on RSABE method. Results showed that both of the 90% CIs for the log-transformed ratios of AUC and C max of 7-desmethyl-agomelatine and 3-hydroxy-agomelatine were within the predetermined bioequivalence range. The 90% CIs for natural log-transformed ratios of C max, AUC0-t and AUC0-∞ of agomelatine (104.42-139.86, 101.33-123.83 and 97.90-117.94) were within the RSABE acceptance limits, and 3-hydroxy-agomelatine (105.55-123.03, 101.95-109.10 and 101.72-108.70) and 7-desmethyl-agomelatine (104.50-125.23, 102.36-111.50 and 101.62-110.64) were within the FDA bioequivalence definition intervals (0.80-1.25 for AUC and 0.75-1.33 for C max). The RSABE approach was successful in evaluating the bioequivalence of these two formulations. PMID:26904401

  16. Implementation of a reference-scaled average bioequivalence approach for highly variable generic drug products of agomelatine in Chinese subjects

    PubMed Central

    Tang, Fang; Zhou, Rui; Cheng, Zeneng; Yang, Guoping; Chen, Aiqiao; Liu, Zhi; Tan, Hongyi; Yang, Shuang; Li, Sanwang; Mu, Lingli; Yu, Peng

    2015-01-01

    The aim of this study was to apply the reference-scaled average bioequivalence (RSABE) approach to evaluate the bioequivalence of 2 formulations of agomelatine, and to investigate the pharmacokinetic properties of agomelatine in Chinese healthy male subjects. This was performed in a single-dose, randomized-sequence, open-label, four-way crossover study with a one-day washout period between doses. Healthy Chinese males were randomly assigned to receive 25 mg of either the test or reference formulation. The formulations were considered bioequivalent if 90% confidence intervals (CIs) for the log-transformed ratios and ratio of geometric means (GMR) of AUC and Cmax of agomelatine were within the predetermined bioequivalence range based on RSABE method. Results showed that both of the 90% CIs for the log-transformed ratios of AUC and Cmax of 7-desmethyl-agomelatine and 3-hydroxy-agomelatine were within the predetermined bioequivalence range. The 90% CIs for natural log-transformed ratios of Cmax, AUC0–t and AUC0–∞ of agomelatine (104.42–139.86, 101.33–123.83 and 97.90–117.94) were within the RSABE acceptance limits, and 3-hydroxy-agomelatine (105.55–123.03, 101.95–109.10 and 101.72–108.70) and 7-desmethyl-agomelatine (104.50–125.23, 102.36–111.50 and 101.62–110.64) were within the FDA bioequivalence definition intervals (0.80–1.25 for AUC and 0.75–1.33 for Cmax). The RSABE approach was successful in evaluating the bioequivalence of these two formulations. PMID:26904401

  17. Comparison of generic (SF-36) vs. disease-specific (GERD-HRQL) quality-of-life scales for gastroesophageal reflux disease.

    PubMed

    Velanovich, V

    1998-01-01

    The Gastroesophageal Reflux Disease-Health-Related Quality-Of-Life (GERD-HRQL) scale was developed to objectively quantify symptom severity. It was compared to a "gold standard" health survey, the SF-36. Forty-three patients treated either medically or surgically for gastroesophageal reflux disease were asked to complete both the GERD-HRQL and the SF-36. They were asked the following: (1) Which questionnaire do you like best? (2) Which questionnaire was easier to understand? (3) Which questionnaire was more reflective of the problems you have with reflux disease? (4) Given the choice, which questionnaire would you rather fill out? Patients were asked to state their overall satisfaction with their present reflux symptom conditions. Multivariate analysis showed that the only significant predictor of patient satisfaction was the total GERD-HRQL score (P <0.00001). There were differences in the SF-36 domains of physical function (88.7 vs. 65.3; P = 0.004) and general health (68 vs. 46.5; P = 0.006). There were no correlations between the total GERD-HRQL scores and the SF-36 domain scores. Fifty-nine percent of patients preferred the GERD-HRQL questionnaire, 62% felt it was easier to understand, 86% felt it was more reflective of their symptoms, and 67% said they would rather use it over the SF-36. The GERD-HRQL better assesses symptom severity for gastroesophageal reflux disease than the generic SF-36

  18. Exploring Hardware Support For Scaling Irregular Applications on Multi-node Multi-core Architectures

    SciTech Connect

    Secchi, Simone; Ceriani, Marco; Tumeo, Antonino; Villa, Oreste; Palermo, Gianluca; Raffo, Luigi

    2013-06-05

    With the recent emergence of large-scale knowledge dis- covery, data mining and social network analysis, irregular applications have gained renewed interest. Classic cache-based high-performance architectures do not provide optimal performances with such kind of workloads, mainly due to the very low spatial and temporal locality of the irregular control and memory access patterns. In this paper, we present a multi-node, multi-core, fine-grained multi-threaded shared-memory system architecture specifically designed for the execution of large-scale irregular applications, and built on top of three pillars, that we believe are fundamental to support these workloads. First, we offer transparent hardware support for Partitioned Global Address Space (PGAS) to provide a large globally-shared address space with no software library overhead. Second, we employ multi-threaded multi-core processing nodes to achieve the necessary latency tolerance required by accessing global memory, which potentially resides in a remote node. Finally, we devise hardware support for inter-thread synchronization on the whole global address space. We first model the performances by using an analytical model that takes into account the main architecture and application characteristics. We describe the hardware design of the proposed cus- tom architectural building blocks that provide support for the above- mentioned three pillars. Finally, we present a limited-scale evaluation of the system on a multi-board FPGA prototype with typical irregular kernels and benchmarks. The experimental evaluation demonstrates the architecture performance scalability for different configurations of the whole system.

  19. From Cores to Envelopes to Disks: A Multi-scale View of Magnetized Star Formation

    NASA Astrophysics Data System (ADS)

    Hull, Charles L. H.

    2014-12-01

    Observations of polarization in star forming regions have been made across many wavelengths, many size scales, and many stages of stellar evolution. One of the overarching goals of these observations has been to determine the importance of magnetic fields -- which are the cause of the polarization -- in the star formation process. We begin by describing the commissioning and the calibration of the 1.3 mm dual-polarization receiver system we built for CARMA (the Combined Array for Research in Millimeter-wave Astronomy), a radio telescope in the eastern Sierra region of California. One of the primary science drivers behind the polarization system is to observe polarized thermal emission from dust grains in the dense clumps of dust and gas where the youngest, Class 0 protostars are forming. We go on to describe the CARMA TADPOL survey -- the largest high-resolution (~1000 AU scale) survey to date of dust polarization in low-mass protostellar cores -- and discuss our main findings: (1) Magnetic fields (B-fields) on scales of ~1000 AU are not tightly aligned with protostellar outflows. Rather, the data are consistent both with scenarios where outflows and magnetic fields are preferentially misaligned (perpendicular) and where they are randomly aligned. (2) Sources with high CARMA polarization fractions have consistent B-field orientations on large scales (~20'', measured using single-dish submillimeter telescopes) and small scales (~2.5'', measured by CARMA). We interpret this to mean that in at least some cases B-fields play a role in regulating the infall of material all the way down to the ~1000 AU scales of protostellar envelopes. Finally, (3) While on the whole outflows appear to be randomly aligned with B-fields, in sources with low polarization fractions there is a hint that outflows are preferentially perpendicular to small-scale B-fields, which suggests that in these sources the fields have been wrapped up by envelope rotation. This work shows that the ~1000 AU

  20. Scaling the Pseudo-Spectral Mountain: Spherical Anelasticity at 10,000 Cores

    NASA Astrophysics Data System (ADS)

    Featherstone, N. A.

    2012-12-01

    The last decade has witnessed a blossoming in the use of numerical simulations to examine global-scale dynamo processes operating in stellar convection zones. Increasing availability of computational resources has allowed many insights into these phenomena to be gained through the wide application of the Anelastic Spherical Harmonic (ASH) code in particular. ASH has been applied extensively to the study of solar-like stars; most notably to the various dynamo states attainable within such stars and to the processes that drive and maintain the solar differential rotation. Its application has also provided a window into the inner workings of convection zones with a decidedly less shellular geometry, such as the fully convective, low-mass M stars, or the convective cores of high-mass A- and B-type stars. ASH solves the anelastic MHD equations within a pseudo-spectral framework, employing a spherical harmonic decomposition on spherical shells and either a Chebyshev polynomial or finite-difference formulation in the radial direction. The spectral transforms associated with the pseudo-spectral treatment, and the inherent Poisson solve arising from the anelastic formulation, imply that ASH suffers from the same communication drawbacks associated with many other pseudo-spectral methods. Historically, the efficient application of this code has been limited to the use of roughly 2000 cores for problems with 10243 gridpoints, but recently, a thorough restructuring of ASH has allowed for strong scaling of 10243 class problems out to 17,000 cores. These improvements in scalability arise primarily from a careful load balancing of the Poisson solve and its associated communication pathways, as well as from aggregation of the spectral transform communication. I will discuss in detail the current implementation of ASH, accomplished entirely with MPI, and then touch on why an OpenMP hybridization (recently successful in some pseudo-spectral applications) seems unlikely to yield

  1. Soil hydrophobicity - relating effects at atomic, molecular, core and national scales

    NASA Astrophysics Data System (ADS)

    Matthews, Peter; Doerr, Stefan; Van Keulen, Geertje; Dudley, Ed; Francis, Lewis; Whalley, Richard; Gazze, Andrea; Hallin, Ingrid; Quinn, Gerry; Sinclair, Kat; Ashton, Rhys

    2016-04-01

    The detrimental impacts of soil hydrophobicity include increased runoff, erosion and flooding, reduced biomass production, inefficient use of irrigation water and preferential leaching of pollutants. Its impacts may exacerbate flood risk associated with more extreme drought and precipitation events predicted with UK climate change scenarios. The UK's Natural Environment Research Council (NERC) has therefore funded a major research programme to investigate soil hydrophobicity over length scales ranging from atomic through molecular, core and landscape scale. This presentation gives an overview of the findings to date. The programme is predicated on the hypothesis that changes in soil protein abundance and localization, induced by variations in soil moisture and temperature, are crucial driving forces for transitions between hydrophobic and hydrophilic conditions at soil particle surfaces. Three soils were chosen based on the severity of hydrophobicity that can be achieved in the field: severe to extreme (Cefn Bryn, Gower, Wales), intermediate to severe (National Botanical Garden, Wales), and subcritical (Park Grass, Rothamsted Research near London). The latter is already highly characterised so was also used as a control. Hydrophobic/ hydrophilic transitions were measured from water droplet penetration times. Scientific advances in the following five areas will be described: (i) the identification of these soil proteins by proteomic methods, using a novel separation method which reduces interference by humic acids, and allows identification by ESI and MALDI TOF mass spectrometry and database searches, (ii) the examination of such proteins, which form ordered hydrophobic ridges, and measurement of their elasticity, stickiness and hydrophobicity at nano- to microscale using atomic force microscopy adapted for the rough surfaces of soil particles, (iii) the novel use of a picoliter goniometer to show hydrophobic effects at a 1 micron diameter droplet level, which

  2. Emerging Methods in Sub Core-Scale Imaging and Characterization of the Influence of Heterogeneity on Flow in Rocks (Invited)

    NASA Astrophysics Data System (ADS)

    Benson, S. M.; Hingerl, F.; Pini, R.

    2013-12-01

    New imaging techniques and approaches are providing unparalleled insight into the influence of sub-core scale heterogeneities on single and multiphase flows. Quantification of sub core-scale porosity, permeability, and even capillary pressure curves at a spatial scale of about 1-10 cubic millimeters is now possible. This scale provides a critical link in the continuum of spatial scales needed to link pore-scale processes to core-scale and field scale flow and transport. Data from such studies can be used to directly test the veracity of models for flow and transport in heterogeneous rocks, provide data for multi-stage upscaling, and reveal insights about physical/chemical processes heretofore neglected. Here we present data from three emerging techniques capable of imaging and quantifying transport properties and phenomena at the sub-core scale: magnetic resonance imaging (MRI); positron emission tomography (PET); and X-Ray CT scanning. Direct imaging of spatially resolved fluid velocities and porosity is possible with MRI (Romanenko et al., 2012). These data can be inverted to provide permeability and porosity maps at a spatial scale of ~10 cubic millimeter. PET imaging can be used to track movement of a radioactive tracer through a rock and simultaneously measure effluent tracer concentrations at a similar resolution (Boutchko et al., 2012). X-ray CT scanning of multiphase flow experiments can be used to measure capillary pressure curves and through scaling relationships, to calculate permeability at a scale of about 1 cubic millimeters(Krause et al., 2011; Pini et al., 2013). Strengths and shortcomings of these techniques are discussed--along with the benefits of combining them. Together these techniques provide a new platform from which to probe more deeply the ubiquitous influence of heterogeneity on subsurface flow and transport processes, and ultimately improve predictions of subsurface transport. Boutchk et al., 2012. Imaging and modeling of flow in porous

  3. A Rasch scaling validation of a 'core' near-death experience.

    PubMed

    Lange, Rense; Greyson, Bruce; Houran, James

    2004-05-01

    For those with true near-death experiences (NDEs), Greyson's (1983, 1990) NDE Scale satisfactorily fits the Rasch rating scale model, thus yielding a unidimensional measure with interval-level scaling properties. With increasing intensity, NDEs reflect peace, joy and harmony, followed by insight and mystical or religious experiences, while the most intense NDEs involve an awareness of things occurring in a different place or time. The semantics of this variable are invariant across True-NDErs' gender, current age, age at time of NDE, and latency and intensity of the NDE, thus identifying NDEs as 'core' experiences whose meaning is unaffected by external variables, regardless of variations in NDEs' intensity. Significant qualitative and quantitative differences were observed between True-NDErs and other respondent groups, mostly revolving around the differential emphasis on paranormal/mystical/religious experiences vs. standard reactions to threat. The findings further suggest that False-Positive respondents reinterpret other profound psychological states as NDEs. Accordingly, the Rasch validation of the typology proposed by Greyson (1983) also provides new insights into previous research, including the possibility of embellishment over time (as indicated by the finding of positive, as well as negative, latency effects) and the potential roles of religious affiliation and religiosity (as indicated by the qualitative differences surrounding paranormal/mystical/religious issues).

  4. Relationship of core-scale heterogeneity with non-Darcy flow coefficients

    SciTech Connect

    Al-Rumhy, M.H.; Kalam, M.Z.

    1996-06-01

    An experimental research program to investigate the effects of liquid saturations upon non-Darcy flow coefficients is presented. the presence of a wetting phase fluid plays an important role in high velocity flow of a gas well, producing condensate or water, and in propped fractures containing liquid saturations. This study initially examines the errors commonly encountered but ignored in evaluating the permeabilities and the coefficient of inertial resistance during the flow of gases through porous media. Experimental techniques, such as constant overburden pressure, changing overburden pressure, forward flow, and backpressure flow, are applied to optimize and obtain accurate evaluations of Klinkenberg parameters and inertial resistance coefficients for a selection of Omani reservoir cores. Gas-slippage factor significantly influences the derived viscous and inertial coefficients from high-velocity gas flow data. An increasing wetting phase saturation increases the non-Darcy coefficient up to thirty-fold. Analysis of the experimental data revealed that unique relationships exist between the non-Darcy flow coefficients and the equivalent liquid permeability, porosity, and liquid saturation. Heterogeneity of the core as mapped by pore-scale measurements provide an insight into the mechanism for such a large increase in the non-Darcy coefficients.

  5. Small-scale cyclones on the periphery of a Gulf Stream warm-core ring

    NASA Technical Reports Server (NTRS)

    Kennelly, M. A.; Evans, R. H.; Joyce, T. M.

    1985-01-01

    Small-scale cyclones found around Gulf Stream warm-core ring 82B are investigated by using infrared satellite images and current information obtained with an acoustic-Doppler velocimeter. Currents in these cyclones reveal speeds ranging from 20 to 80 cm/s. One small cyclone or 'ringlet' found in June 1982 was studied extensively by removing the basic rotational velocities of 82B. The azimuthal velocity field for this ringlet was used with the gradient current equation to calculate the absolute dynamic topography at 100 dbar. It was found that the ringlet was 13 dyn-cm lower than its surroundings. In addition, neglect of the centrifugal term would have changed the dynamic topography of the ringlet by 30 percent. From a comparison with CTD data the absolute reference level was determined, and a vertical profile of horizontal currents was calculated for the ringlet. Other cyclones were found throughout the slope water region around warm-core ring 82B with observable lifetimes of 1 to 2 weeks. The northeast quadrant of 82B was a favored generation site for ringlets. Two cyclones were observed to form in this region and were advected anticyclonically around 82B. Typically, at any one time, six cyclones with diameters of approximately 40 to 50 km can be detected north of the Gulf Stream by using satellite images.

  6. Laboratory measurements on core-scale sediment/hydrate samples topredice reservoir behavior

    SciTech Connect

    Kneafsey, Timothy J.; Seol, Yongkoo; Moridis, George J.; Tomutsa,Liviu; Freifeld, Barry M.

    2005-11-02

    Measurements on hydrate-bearing laboratory and field samplesare necessary in order to provide realistic bounds on parameters used innumerically modeling the production of natural gas from hydrate-bearingreservoirs. The needed parameters include thermal conductivity,permeability, relative permeability-saturation(s) relationships, andcapillary pressure-saturation(s) relationships. We have developed atechnique to make hydrate-bearing samples ranging in scale from coreplug-size to core-size in the laboratory to facilitate making thesemeasurements. In addition to pressure and temperature measurements, weuse x-ray computed tomography scanning to provide high-resolution dataproviding insights on processes occurring in our samples. Several methodsare available to make gas hydrates in the laboratory, and we expect thatthe method used to make the hydrate will impact the behavior of thehydrate sample, and the parameters measured.

  7. Patients’ beliefs about generic medicines in Malaysia

    PubMed Central

    Wong, Zhi Y.; Hassali, Mohamed A.; Alrasheedy, Alian A.; Saleem, Fahad; Yahaya, Abdul H.; Aljadhey, Hisham

    2014-01-01

    Background: Acceptance of generic medicines by patients is an essential factor given that they are the end users of these medicines. In fact, adequate knowledge and positive perceptions are prerequisite to patients’ acceptance and use of generic medicines. Objective: To assess the current belief and views of patients about generic medicines in Malaysia. Method: This was a self-administered questionnaire-based study. The study was conducted with patients visiting outpatient pharmacy department at a tertiary care hospital in Malaysia. The Malaysian version of Generic Medicines Scale (GMS) was used. The GMS consists of two subscales: efficacy and similarity of generic medicines to original brand medicines. The efficacy subscale consists of 10 items while the similarity subscale consists of 6 items. The responses to the items were framed as a five-point Likert scale (1=strongly disagree to 5=strongly agree). Results: A total of 202 out of 300 patients participated in the study, giving a response rate of 67.3%. In this study, only 49% of them (n=99) knew the term ‘generic medicine’. Moreover, only 53.5% of the respondents (n=108) believed that the efficacy of generic medicines was the same as original brand medicines. In terms of quality, only 44% of the respondents (n=89) disagreed that generic medicines were of a lower quality. About one third (n=65, 32.2%) believed that generic medicines were cheaper because they were less efficacious. In terms of side effects, 44.5% of the respondents (n=90) believed that generic medicines had the same side effect profile as original brand medicines. Conclusions: The study finding showed that almost half of the respondents had negative belief in generic medicines. Similarly, many patients were not aware of the similarities and differences between generic and original brand medicines. Therefore, there is a need to provide patients with adequate information about generic medicines. PMID:25580171

  8. A Nonlinear Dynamic Inversion Predictor-Based Model Reference Adaptive Controller for a Generic Transport Model

    NASA Technical Reports Server (NTRS)

    Campbell, Stefan F.; Kaneshige, John T.

    2010-01-01

    Presented here is a Predictor-Based Model Reference Adaptive Control (PMRAC) architecture for a generic transport aircraft. At its core, this architecture features a three-axis, non-linear, dynamic-inversion controller. Command inputs for this baseline controller are provided by pilot roll-rate, pitch-rate, and sideslip commands. This paper will first thoroughly present the baseline controller followed by a description of the PMRAC adaptive augmentation to this control system. Results are presented via a full-scale, nonlinear simulation of NASA s Generic Transport Model (GTM).

  9. Determining pore length scales and pore surface relaxivity of rock cores by internal magnetic fields modulation at 2MHz NMR.

    PubMed

    Liu, Huabing; Nogueira d'Eurydice, Marcel; Obruchkov, Sergei; Galvosas, Petrik

    2014-09-01

    Pore length scales and pore surface relaxivities of rock cores with different lithologies were studied on a 2MHz Rock Core Analyzer. To determine the pore length scales of the rock cores, the high eigenmodes of spin bearing molecules satisfying the diffusion equation were detected with optimized encoding periods in the presence of internal magnetic fields Bin. The results were confirmed using a 64MHz NMR system, which supports the feasibility of high eigenmode detection at fields as low as 2MHz. Furthermore, this methodology was combined with relaxometry measurements to a two-dimensional experiment, which provides correlation between pore length and relaxation time. This techniques also yields information on the surface relaxivity of the rock cores. The estimated surface relaxivities were then compared to the results using an independent NMR method.

  10. Infrared length scale and extrapolations for the no-core shell model

    SciTech Connect

    Wendt, K. A.; Forssén, C.; Papenbrock, T.; Sääf, D.

    2015-06-03

    In this paper, we precisely determine the infrared (IR) length scale of the no-core shell model (NCSM). In the NCSM, the A-body Hilbert space is truncated by the total energy, and the IR length can be determined by equating the intrinsic kinetic energy of A nucleons in the NCSM space to that of A nucleons in a 3(A-1)-dimensional hyper-radial well with a Dirichlet boundary condition for the hyper radius. We demonstrate that this procedure indeed yields a very precise IR length by performing large-scale NCSM calculations for 6Li. We apply our result and perform accurate IR extrapolations for bound states of 4He, 6He, 6Li, and 7Li. Finally, we also attempt to extrapolate NCSM results for 10B and 16O with bare interactions from chiral effective field theory over tens of MeV.

  11. An ice core derived 1013-year catchment-scale annual rainfall reconstruction in subtropical eastern Australia

    NASA Astrophysics Data System (ADS)

    Tozer, Carly R.; Vance, Tessa R.; Roberts, Jason L.; Kiem, Anthony S.; Curran, Mark A. J.; Moy, Andrew D.

    2016-05-01

    Paleoclimate research indicates that the Australian instrumental climate record (˜ 100 years) does not cover the full range of hydroclimatic variability that is possible. To better understand the implications of this on catchment-scale water resources management, a 1013-year (1000-2012 common era (CE)) annual rainfall reconstruction was produced for the Williams River catchment in coastal eastern Australia. No high-resolution paleoclimate proxies are located in the region and so a teleconnection between summer sea salt deposition recorded in ice cores from East Antarctica and rainfall variability in eastern Australia was exploited to reconstruct the catchment-scale rainfall record. The reconstruction shows that significantly longer and more frequent wet and dry periods were experienced in the preinstrumental compared to the instrumental period. This suggests that existing drought and flood risk assessments underestimate the true risks due to the reliance on data and statistics obtained from only the instrumental record. This raises questions about the robustness of existing water security and flood protection measures and has serious implications for water resources management, infrastructure design and catchment planning. The method used in this proof of concept study is transferable and enables similar insights into the true risk of flood/drought to be gained for other paleoclimate proxy poor regions for which suitable remote teleconnected proxies exist. This will lead to improved understanding and ability to deal with the impacts of multi-decadal to centennial hydroclimatic variability.

  12. WETTABILITY AND IMBIBITION: MICROSCOPIC DISTRIBUTION OF WETTING AND ITS CONSEQUENCES AT THE CORE AND FIELD SCALES

    SciTech Connect

    Jill S. Buckley; Norman R. Morrow; Chris Palmer; Purnendu K. Dasgupta

    2003-02-01

    The questions of reservoir wettability have been approached in this project from three directions. First, we have studied the properties of crude oils that contribute to wetting alteration in a reservoir. A database of more than 150 different crude oil samples has been established to facilitate examination of the relationships between crude oil chemical and physical properties and their influence on reservoir wetting. In the course of this work an improved SARA analysis technique was developed and major advances were made in understanding asphaltene stability including development of a thermodynamic Asphaltene Solubility Model (ASM) and empirical methods for predicting the onset of instability. The CO-Wet database is a resource that will be used to guide wettability research in the future. The second approach is to study crude oil/brine/rock interactions on smooth surfaces. Contact angle measurements were made under controlled conditions on mica surfaces that had been exposed to many of the oils in the CO-Wet database. With this wealth of data, statistical tests can now be used to examine the relationships between crude oil properties and the tendencies of those oils to alter wetting. Traditionally, contact angles have been used as the primary wetting assessment tool on smooth surfaces. A new technique has been developed using an atomic forces microscope that adds a new dimension to the ability to characterize oil-treated surfaces. Ultimately we aim to understand wetting in porous media, the focus of the third approach taken in this project. Using oils from the CO-Wet database, experimental advances have been made in scaling the rate of imbibition, a sensitive measure of core wetting. Application of the scaling group to mixed-wet systems has been demonstrated for a range of core conditions. Investigations of imbibition in gas/liquid systems provided the motivation for theoretical advances as well. As a result of this project we have many new tools for studying

  13. Development and validation of a generic high-performance liquid chromatography for the simultaneous separation and determination of six cough ingredients: Robustness study on core-shell particles.

    PubMed

    Yehia, Ali Mohamed; Essam, Hebatallah Mohamed

    2016-09-01

    A generally applicable high-performance liquid chromatographic method for the qualitative and quantitative determination of pharmaceutical preparations containing phenylephrine hydrochloride, paracetamol, ephedrine hydrochloride, guaifenesin, doxylamine succinate, and dextromethorphan hydrobromide is developed. Optimization of chromatographic conditions was performed for the gradient elution using different buffer pH values, flow rates and two C18 stationary phases. The method was developed using a Kinetex® C18 column as a core-shell stationary phase with a gradient profile using buffer pH 5.0 and acetonitrile at 2.0 mL/min flow rate. Detection was carried out at 220 nm and linear calibrations were obtained for all components within the studied ranges. The method was fully validated in agreement with ICH guidelines. The proposed method is specific, accurate and precise (RSD% < 3%). Limits of detection are lower than 2.0 μg/mL. Qualitative and quantitative responses were evaluated using experimental design to assist the method robustness. The method was proved to be highly robust against 10% change in buffer pH and flow rate (RSD% < 10%), however, the flow rate may significantly influence the quantitative responses of phenylephrine, paracetamol, and doxylamine (RSD% > 10%). Satisfactory results were obtained for commercial combinations analyses. Statistical comparison between the proposed chromatographic and official methods revealed no significant difference. PMID:27404374

  14. Spatial scaling of core and dominant forest cover in the Upper Mississippi and Illinois River floodplains, USA

    USGS Publications Warehouse

    De Jager, Nathan R.; Rohweder, Jason J.

    2011-01-01

    Different organisms respond to spatial structure in different terms and across different spatial scales. As a consequence, efforts to reverse habitat loss and fragmentation through strategic habitat restoration ought to account for the different habitat density and scale requirements of various taxonomic groups. Here, we estimated the local density of floodplain forest surrounding each of ~20 million 10-m forested pixels of the Upper Mississippi and Illinois River floodplains by using moving windows of multiple sizes (1–100 ha). We further identified forest pixels that met two local density thresholds: 'core' forest pixels were nested in a 100% (unfragmented) forested window and 'dominant' forest pixels were those nested in a >60% forested window. Finally, we fit two scaling functions to declines in the proportion of forest cover meeting these criteria with increasing window length for 107 management-relevant focal areas: a power function (i.e. self-similar, fractal-like scaling) and an exponential decay function (fractal dimension depends on scale). The exponential decay function consistently explained more variation in changes to the proportion of forest meeting both the 'core' and 'dominant' criteria with increasing window length than did the power function, suggesting that elevation, soil type, hydrology, and human land use constrain these forest types to a limited range of scales. To examine these scales, we transformed the decay constants to measures of the distance at which the probability of forest meeting the 'core' and 'dominant' criteria was cut in half (S 1/2, m). S 1/2 for core forest was typically between ~55 and ~95 m depending on location along the river, indicating that core forest cover is restricted to extremely fine scales. In contrast, half of all dominant forest cover was lost at scales that were typically between ~525 and 750 m, but S 1/2 was as long as 1,800 m. S 1/2 is a simple measure that (1) condenses information derived from multi-scale

  15. Mapping fine-scale structure near the core-mantle boundary beneath USArray

    NASA Astrophysics Data System (ADS)

    Mancinelli, Nicholas; Shearer, Peter; Thomas, Christine

    2015-04-01

    Recent studies agree that weak (r.m.s of 0.1%) small-scale (~6 km) random velocity fluctuations distributed throughout the lowermost mantle explain globally-averaged PKP precursor amplitudes in the 0.7-2.5 Hz frequency band. Precursor amplitudes in individual seismograms, however, exhibit much variability, suggesting that some regions in the lower mantle are more heterogeneous than others. It is difficult to reliably map differences in scattering strength from single seismograms due to reciprocity considerations, but seismic arrays provide a means to distinguish between source- and receiver-side scattering. We use a traditional beamforming method to measure the slowness and azimuth of scattered energy incident upon the array, and a migration method to map coherent precursor energy to points of origin near the core-mantle boundary. The focus of this paper is to test the robustness of these methods with the wealth of USArray data. We conduct several tests to address the following questions: 1) how well does traditional beamforming agree with results from the migration method?, 2) how consistent are structures resolved by different subsets of receivers for a given event?, 3) how consistent are structures resolved by a given set of stations for distinct, but nearby, events?, and 4) how consistent are structures resolved when using seismograms filtered at different frequencies? The coarse spacing (~75 km) of USArray limits our ability to make reliable slowness measurements because of spatial aliasing. It may be possible, however, to make measurements of longer-period precursors scattered by larger-scale (~100 km) structures. Another possible solution to the spatial aliasing problem is to include additional data from PASSCAL experiments with densely-spaced stations that were deployed as the Transportable Array rolled across North America.

  16. Experimental and Numerical Observations of Hydrate Reformation during Depressurization in a Core-Scale Reactor

    SciTech Connect

    Seol, Yongkoo; Myshakin, Evgeniy

    2011-01-01

    Gas hydrate has been predicted to reform around a wellbore during depressurization-based gas production from gas hydrate-bearing reservoirs. This process has an adverse effect on gas production rates and it requires time and sometimes special measures to resume gas flow to producing wells. Due to lack of applicable field data, laboratory scale experiments remain a valuable source of information to study hydrate reformation. In this work, we report laboratory experiments and complementary numerical simulations executed to investigate the hydrate reformation phenomenon. Gas production from a pressure vessel filled with hydrate-bearing sand was induced by depressurization with and without heat flux through the boundaries. Hydrate decomposition was monitored with a medical X-ray CT scanner and pressure and temperature measurements. CT images of the hydrate-bearing sample were processed to provide 3-dimensional data of heterogeneous porosity and phase saturations suitable for numerical simulations. In the experiments, gas hydrate reformation was observed only in the case of no-heat supply from surroundings, a finding consistent with numerical simulation. By allowing gas production on either side of the core, numerical simulations showed that initial hydrate distribution patterns affect gas distribution and flow inside the sample. This is a direct consequence of the heterogeneous pore network resulting in varying hydraulic properties of the hydrate-bearing sediment.

  17. An ice core derived 1013-year catchment scale annual rainfall reconstruction in subtropical eastern Australia

    NASA Astrophysics Data System (ADS)

    Tozer, C. R.; Vance, T. R.; Roberts, J.; Kiem, A. S.; Curran, M. A. J.; Moy, A. D.

    2015-12-01

    Paleoclimate research indicates that the instrumental climate record (~100 years in Australia) does not cover the full range of hydroclimatic variability possible. To better understand the implications of this for catchment-scale water resources management, an annual rainfall reconstruction is produced for the Williams River catchment in coastal eastern Australia. No high resolution palaeoclimate proxies are located in the region and so a teleconnection between summer sea salt deposition recorded in ice cores from East Antarctica and rainfall variability in eastern Australia was exploited to reconstruct 1013 years of rainfall (AD 1000-2012). The reconstruction shows that significantly longer and more frequent wet and dry periods were experienced in the preinstrumental compared to the instrumental period. This suggests that existing drought and flood risk assessments underestimate the true risks due to the reliance on data and statistics obtained from only the instrumental record. This raises questions about the robustness of existing water security and flood protection measures and has serious implications for water resources management, infrastructure design, and catchment planning. The method used in this proof of concept study is transferable and enables similar insights into the true risk of flood/drought to be gained for other locations that are teleconnected to East Antarctica. This will lead to improved understanding and ability to deal with the impacts of multidecadal to centennial hydroclimatic variability.

  18. Conceptual Distinctions amongst Generics

    ERIC Educational Resources Information Center

    Prasada, Sandeep; Khemlani, Sangeet; Leslie, Sarah-Jane; Glucksberg, Sam

    2013-01-01

    Generic sentences (e.g., bare plural sentences such as "dogs have four legs" and "mosquitoes carry malaria") are used to talk about "kinds" of things. Three experiments investigated the conceptual foundations of generics as well as claims within the formal semantic approaches to generics concerning the roles of prevalence, cue validity and…

  19. Test plan: Laboratory-scale testing of the first core sample from Tank 102-AZ

    SciTech Connect

    Morrey, E.V.

    1996-03-01

    The overall objectives of the Radioactive Process/Product Laboratory Testing (RPPLT), WBS 1.2.2.05.05, are to confirm that simulated HWVP feed and glass are representative of actual radioactive HWVP feed and glass and to provide radioactive leaching and glass composition data to WFQ. This study will provide data from one additional NCAW core sample (102-AZ Core 1) for these purposes.

  20. Induced core formation time in subcritical magnetic clouds by large-scale trans-Alfvénic flows

    SciTech Connect

    Kudoh, Takahiro; Basu, Shantanu E-mail: basu@uwo.ca

    2014-10-20

    We clarify the mechanism of accelerated core formation by large-scale nonlinear flows in subcritical magnetic clouds by finding a semi-analytical formula for the core formation time and describing the physical processes that lead to them. Recent numerical simulations show that nonlinear flows induce rapid ambipolar diffusion that leads to localized supercritical regions that can collapse. Here, we employ non-ideal magnetohydrodynamic simulations including ambipolar diffusion for gravitationally stratified sheets threaded by vertical magnetic fields. One of the horizontal dimensions is eliminated, resulting in a simpler two-dimensional simulation that can clarify the basic process of accelerated core formation. A parameter study of simulations shows that the core formation time is inversely proportional to the square of the flow speed when the flow speed is greater than the Alfvén speed. We find a semi-analytical formula that explains this numerical result. The formula also predicts that the core formation time is about three times shorter than that with no turbulence, when the turbulent speed is comparable to the Alfvén speed.

  1. Fuel cell performance of palladium-platinum core-shell electrocatalysts synthesized in gram-scale batches

    DOE PAGESBeta

    Khateeb, Siddique; Su, Dong; Guerreo, Sandra; Darling, Robert M.; Protsailo, Lesia V.; Shao, Minhua

    2016-05-03

    This article presents the performance of palladium-platinum core-shell catalysts (Pt/Pd/C) for oxygen reduction synthesized in gram-scale batches in both liquid cells and polymer-electrolyte membrane fuel cells. Core-shell catalyst synthesis and characterization, ink fabrication, and cell assembly details are discussed. The Pt mass activity of the Pt/Pd core-shell catalyst was 0.95 A mg–1 at 0.9 V measured in liquid cells (0.1 M HClO4), which was 4.8 times higher than a commercial Pt/C catalyst. The performances of Pt/Pd/C and Pt/C in large single cells (315 cm2) were assessed under various operating conditions. The core-shell catalyst showed consistently higher performance than commercial Pt/Cmore » in fuel cell testing. A 20–60 mV improvement across the whole current density range was observed on air. Sensitivities to temperature, humidity, and gas composition were also investigated and the core-shell catalyst showed a consistent benefit over Pt under all conditions. However, the 4.8 times activity enhancement predicated by liquid cell measurements was not fully realized in fuel cells.« less

  2. Core Heat Flow and Suppression of Mantle Plumes by Plate-Scale Mantle Flow: Results From Laboratory Experiments

    NASA Astrophysics Data System (ADS)

    Gonnermann, H. M.; Jellinek, A. M.; Richards, M. A.; Manga, M.

    2002-12-01

    Heat flow from the Earth's core to the mantle remains an unresolved quantity. Its value has implications for the core's thermal evolution and growth of the inner core, the geodynamo, and the relative abundance of radioactive elements in the core and mantle. Core heat flow is affected by dynamics of the lowermost mantle in three ways: (1) advection of heat by plume instabilities; (2) conductive heating of subducted material; and (3) suppression of plume instabilities, as well as advection of heat by plate-scale mantle flow. We present results from a boundary-layer analysis and laboratory experiments aimed at understanding the effects of an imposed large-scale circulation on thermal convection at high-Rayleigh number (106<=Ra<=109) in a fluid with a strongly temperature-dependent viscosity. The ultimate goal of this work is to better understand the effect of plate-scale mantle flow on heat flux across the CMB and on the dynamics of plume formation at the CMB. Our theoretical analysis is complemented by lab experiments, in which a layer of corn syrup is heated from below and a large-scale flow is induced in the fluid above the hot boundary. We identify 4 convective regions associated with high-Rayleigh number convection in the presence of a large-scale flow: (1) a subcritical TBL region (Domain I), where plume instabilities are suppressed by the advective thinning of the TBL and heat flux is increased relative to convection without large-scale flow; (2) a supercritical TBL region (Domain II), where plume instabilities are no longer suppressed and heat flux is equal to convection without large-scale flow; (3) a flow-dominated region (Domain III), which is free of plumes; and (4) a plume-dominated domain (Domain IV), where the interaction of hot buoyant plumes and imposed large-scale flow results in lateral advection and distortion of rising plumes. In addition, we present a boundary-layer analysis that predicts heat flux, Q, from a hot surface as a function of imposed

  3. Scaling analysis of the coupled heat transfer process in the high-temperature gas-cooled reactor core

    SciTech Connect

    Conklin, J.C.

    1986-08-01

    The differential equations representing the coupled heat transfer from the solid nuclear core components to the helium in the coolant channels are scaled in terms of representative quantities. This scaling process identifies the relative importance of the various terms of the coupled differential equations. The relative importance of these terms is then used to simplify the numerical solution of the coupled heat transfer for two bounding cases of full-power operation and depressurization from full-system operating pressure for the Fort St. Vrain High-Temperature Gas-Cooled Reactor. This analysis rigorously justifies the simplified system of equations used in the nuclear safety analysis effort at Oak Ridge National Laboratory.

  4. Large-Scale Gene Relocations following an Ancient Genome Triplication Associated with the Diversification of Core Eudicots

    PubMed Central

    Wang, Yupeng; Ficklin, Stephen P.; Wang, Xiyin; Feltus, F. Alex; Paterson, Andrew H.

    2016-01-01

    Different modes of gene duplication including whole-genome duplication (WGD), and tandem, proximal and dispersed duplications are widespread in angiosperm genomes. Small-scale, stochastic gene relocations and transposed gene duplications are widely accepted to be the primary mechanisms for the creation of dispersed duplicates. However, here we show that most surviving ancient dispersed duplicates in core eudicots originated from large-scale gene relocations within a narrow window of time following a genome triplication (γ) event that occurred in the stem lineage of core eudicots. We name these surviving ancient dispersed duplicates as relocated γ duplicates. In Arabidopsis thaliana, relocated γ, WGD and single-gene duplicates have distinct features with regard to gene functions, essentiality, and protein interactions. Relative to γ duplicates, relocated γ duplicates have higher non-synonymous substitution rates, but comparable levels of expression and regulation divergence. Thus, relocated γ duplicates should be distinguished from WGD and single-gene duplicates for evolutionary investigations. Our results suggest large-scale gene relocations following the γ event were associated with the diversification of core eudicots. PMID:27195960

  5. Short period ScP phase amplitude calculations for core-mantle boundary with intermediate scale topography

    NASA Astrophysics Data System (ADS)

    Shen, Zhichao; Ni, Sidao; Wu, Wenbo; Sun, Daoyuan

    2016-04-01

    The core-mantle boundary (CMB) topography plays a key role in constraining geodynamic modeling and core-mantle coupling. It's effective to resolve the intermediate lateral scale topography (hundreds of km) with short period core reflected seismic phases (ScP) due to their small Fresnel-zones at short epicentral distances (<3336 km (30°)). We developed a method based on the ray theory and representation theorem to calculate short period ScP synthetics for intermediate lateral scale CMB topography. The CMB topography we introduced here is axisymmetric and specified with two parameters: H (height) and L (diameter, or lateral length scale). Our numerical computation shows that a bump (H > 0) and dip (H < 0) model would cause defocusing/weakening and focusing/amplifying effects on ScP amplitude. Moreover, the effect of frequency and combination of L and H are quantified with the amplification coefficients. Then we applied this method to estimate a possible CMB topography beneath northeastern Japan, and a CMB model with L = 140 km, H = 1.2 km overall matches the observed pattern of 2D PcP/ScP amplitude ratios. However, it is difficult to totally rule out other factors that may also affect PcP/ScP pattern because of limitation of ray-based algorithms we used here. A hybrid method combining ray theory and numerical method is promising for studying complicated 3D structure and CMB topography in the future.

  6. Unlocking the Physiochemical Controls on Organic Carbon Dynamics from the Soil Pore- to Core-Scale

    NASA Astrophysics Data System (ADS)

    Smith, A. P.; Tfaily, M. M.; Bond-Lamberty, B. P.; Todd-Brown, K. E.; Bailey, V. L.

    2015-12-01

    The physical organization of soil includes pore networks of varying size and connectivity. These networks control microbial access to soil organic carbon (C) by spatially separating microorganisms and C by both distance and size exclusion. The extent to which this spatially isolated C is vulnerable to microbial transformation under hydrologically dynamic conditions is unknown, and limits our ability to predict the source and sink capacity of soils. We investigated the effects of shifting hydrologic connectivity and soil structure on greenhouse gas C emissions from surface soils collected from the Disney Wilderness Preserve (Florida, USA). We subjected intact soil cores and re-packed homogenized soil cores to simulated groundwater rise or precipitation, monitoring their CO2 and CH4 emissions over 24 hours. Soil pore water was then extracted from each core using different suctions to sample water retained by pore throats of different sizes and then characterized by Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. Greater respiration rates were observed from homogenized cores compared to intact cores, and from soils wet from below, in which the wetting front is driven by capillary forces, filling fine pores first. This suggests that C located in fine pores may turn over via diffusion processes that lead to the colocation of this C with other resources and microorganisms. Both the complexity and concentration of soluble-C increased with decreasing pore size domains. Pore water extracted from homogenized cores had greater C concentrations than from intact cores, with the greatest concentrations in pore waters sampled from very fine pores, highlighting the importance of soil structure in physically protecting C. These results suggest that the spatial separation of decomposers from C is a key mechanism stabilizing C in these soils. Further research is ongoing to accurately represent this protection mechanism, and the conditions under which it breaks

  7. Children Expect Generic Knowledge to Be Widely Shared

    ERIC Educational Resources Information Center

    Cimpian, Andrei; Scott, Rose M.

    2012-01-01

    The ability to acquire and store generic information (that is, information about entire categories) is at the core of human cognition. Remarkably, even young children place special value on generic information, often inferring that it holds important insights about the world. Here, we tested whether children's assumptions about the nature of…

  8. The Scaling Rule and Fluxon Core Pinning in a High-Field Superconductor with Artificially Introduced Pins

    NASA Astrophysics Data System (ADS)

    Cooley, Lance David

    Flux pinning affects virtually every aspect of high-field superconductivity. Its fundamental mechanism(s) are in principle derived from a complicated theory, but are in practice generally accessed through measuring the field dependence of the bulk flux pinning force (F _{p}(B)). The central piece of information is the shape of the F_{p }(B) curve: It is generally accepted that if, and only if, the curve's shape is constant while the temperature or pin dimension changes, one pinning mechanism is dominant (the 'scaling rule'). During the course of this thesis, we established that the shape of F_{p}(B) is affected by the statistical distribution of the elementary pinning forces (f_{p}). Contrary to prior beliefs, it was concluded that the shape of the bulk pinning force curve for fluxon core pinning is constant, when the distribution is broad, only if the microstructure is fractal. The peak of the F_ {p}(B) curve occurs at a lower field prior models predict, regardless of whether the shape of the curve is constant. When the distribution is narrow, a constant shape occurs, and has the shape predicted for core pinning and direct summation. Thus, the bulk pinning force curve and the elementary pinning mechanism are directly related by the scaling rule only when the f_ {p} distribution is narrow. Within this context, core pinning has been investigated with a specially fabricated Nb-Ti composite having artificially introduced pins, for which the f_{p } distribution is as narrow as can be made. By design, core pinning should be dominant; the shape of the F_{p}(B) curve does not, however, have the predicted form. The results can be explained by a new pinning mechanism, which incorporates the proximity effect and an anisotropic fluxon core, as proposed by Gurevich. It is concluded that the shape of the bulk pinning force curve is very sensitive to the proximity effect, and it can have a peak at a higher field than was previously thought possible for core pinning. The scaling

  9. Bosonics: Phononics, Magnonics, Plasmonics in Nano-Scale Disorder(Nanonics), Metamaterials, Astro-Seismology (Meganonics): Brillouin-Siegel GENERIC: Generalized-Disorder Collective-Boson Mode-Softening Universality-Principle (G...P) With PIPUB Many-Body Localization

    NASA Astrophysics Data System (ADS)

    Siegel, Edward

    Siegel and Matsubara[Statphys-13(`77) Intl.Conf.Lattice-Dyn.(`77)Scripta Met.13,913(`80)]JMMM:5, 1, 84 (`77)22,1:41,58(`80)Mag.Lett.(`80)Phys./Chem.Liquids:4,(4) (`75)5,(1)(76)] generalization to GENERIC Siegel[J.Non-Xline-Sol.40,453(`80)] G...P GENERIC Brillouin[Wave-Propagation in Periodic-Structures(`22)]-Landau[`41]-Feynman[`51]-de Boer[in Phonons/Phonon-Interactions(`64)]-Egelstaff[Intro.Liquid-State(`65)]-Hubbard-Beebe[J.Phys.C(`67)]-``Anderson''[1958]- Siegel [J.Non-Xl.-Sol. 40, 453(`80)] GENERIC many-body localization. GENERIC Hubbard-Beebe[J.Phys.C(`67)] static structure-factor S(k) modulated kinetic-energy ω(k) = ℏ ⌃(2)k⌃(2)/2mS(k) expressing G....P(``bass-ackwardly'') aka homogeneity and isotropy creates GENERIC G...P with GENERIC pseudo-isotropic pseudo-Umklapp backscattering (PIPUB) for GENERIC many-body localization of and/or by mutually interacting collective-bosons: phonons(phononics) with magnons(magnonics) with plasmons(plasmonics) with fermions (electros, holes)...etc. in nano-scale ``disorder'', metamaterials and on very-macro-scales (surprisingly) Bildsten et.al. astro-seismology(meganonics) of red-giant main-sequence stars(Mira, Betelguese)!

  10. Bioequivalence of generic drugs.

    PubMed

    Andrade, Chittaranjan

    2015-09-01

    Generic drugs are bioequivalent to the original brand; this is a prerequisite for marketing approval. It is theoretically possible that one generic drug may overestimate the pharmacokinetic (PK) parameters of the original and another generic may underestimate these PK parameters; in consequence, these 2 generics may not be bioequivalent between themselves. The result could be loss of efficacy or development of drug-related adverse effects if these generics are interchanged in stable patients. In a recent study involving 292 indirect comparisons of generic formulations of 9 different drugs, mathematical modeling showed that in most cases (87.0% for maximum concentration, 90.1% for area under the curve, and 80.5% for both) generic drugs are bioequivalent to each other. These reassuring findings notwithstanding, prudence dictates that, in stable patients, generic drugs should be interchanged only if there is a good reason for it. This is because bioequivalent brands of drugs may differ in their excipient content, and this can result in variations in safety profiles. PMID:26455677

  11. INL Generic Robot Architecture

    SciTech Connect

    2005-03-30

    The INL Generic Robot Architecture is a generic, extensible software framework that can be applied across a variety of different robot geometries, sensor suites and low-level proprietary control application programming interfaces (e.g. mobility, aria, aware, player, etc.).

  12. Bioequivalence of generic drugs.

    PubMed

    Andrade, Chittaranjan

    2015-09-01

    Generic drugs are bioequivalent to the original brand; this is a prerequisite for marketing approval. It is theoretically possible that one generic drug may overestimate the pharmacokinetic (PK) parameters of the original and another generic may underestimate these PK parameters; in consequence, these 2 generics may not be bioequivalent between themselves. The result could be loss of efficacy or development of drug-related adverse effects if these generics are interchanged in stable patients. In a recent study involving 292 indirect comparisons of generic formulations of 9 different drugs, mathematical modeling showed that in most cases (87.0% for maximum concentration, 90.1% for area under the curve, and 80.5% for both) generic drugs are bioequivalent to each other. These reassuring findings notwithstanding, prudence dictates that, in stable patients, generic drugs should be interchanged only if there is a good reason for it. This is because bioequivalent brands of drugs may differ in their excipient content, and this can result in variations in safety profiles.

  13. Scaling to 150K cores: recent algorithm and performance engineering developments enabling XGC1 to run at scale

    SciTech Connect

    Adams, Mark; Ku, Seung-Hoe; Worley, Patrick H; D'Azevedo, Eduardo; Cummings, Julian; Chang, C S

    2009-01-01

    Particle-in-cell (PIC) methods have proven to be effective in discretizing the Vlasov-Maxwell system of equations describing the core of toroidal burning plasmas for many decades. Recent physical understanding of the importance of edge physics for stability and transport in tokamaks has lead to development of the rst fully toroidal edge PIC code XGC1. The edge region poses special problems in meshing for PIC methods due to the lack of closed ux surfaces, which makes eld-line following meshes and coordinate systems problematic. We present a solution to this problem with a semi- eld line following mesh method in a cylindrical coordinate system. Additionally, modern supercomputers require highly concurrent algorithms and implementations, with all levels of the memory hierarchy being efficiently utilized to realize optimal code performance. This paper presents a mesh and particle partitioning method, suitable to our meshing strategy, for use on highly concurrent cache-based computing platforms.

  14. Scaling Graph Community Detection on the Tilera Many-core Architecture

    SciTech Connect

    Chavarría-Miranda, Daniel; Halappanavar, Mahantesh; Kalyanaraman, Anantharaman

    2014-12-01

    In an era when power constraints and data movement are proving to be significant barriers for the application of high-end computing, the Tilera many-core architecture offers a low-power platform exhibiting many important characteristics of future systems, including a large number of simple cores, a sophisticated network-on-chip, and fine-grained control over memory and caching policies. While this emerging architecture has been previously studied for structured compute-intensive kernels, benchmarking the platform for data-bound, irregular applications present significant challenges that have remained unexplored. Community detection is an advanced prototypical graph-theoretic operation with applications in numerous scientific domains including life sciences, cyber security, and power systems. In this work, we explore multiple design strategies toward developing a scalable tool for community detection on the Tilera platform. Using several memory layout and work scheduling techniques we demonstrate speedups of up to 46x on 36 cores of the Tilera TileGX36 platform over the best serial implementation, and also show results that have comparable quality and performance to mainstream x86 platforms. To the best of our knowledge this is the first work addressing graph algorithms on the Tilera platform. This study demonstrates that through careful design space exploration, low-power many-core platforms like Tilera can be effectively exploited for graph algorithms that that embody all the essential characteristics of an irregular application.

  15. Microstructure-dependent mechanical properties of electrospun core-shell scaffolds at multi-scale levels.

    PubMed

    Horner, Christopher B; Ico, Gerardo; Johnson, Jed; Zhao, Yi; Nam, Jin

    2016-06-01

    Mechanical factors among many physiochemical properties of scaffolds for stem cell-based tissue engineering significantly affect tissue morphogenesis by controlling stem cell behaviors including proliferation and phenotype-specific differentiation. Core-shell electrospinning provides a unique opportunity to control mechanical properties of scaffolds independent of surface chemistry, rendering a greater freedom to tailor design for specific applications. In this study, we synthesized electrospun core-shell scaffolds having different core composition and/or core-to-shell dimensional ratios. Two independent biocompatible polymer systems, polyetherketoneketone (PEKK) and gelatin as the core materials while maintaining the shell polymer with polycaprolactone (PCL), were utilized. The mechanics of such scaffolds was analyzed at the microscale and macroscales to determine the potential implications it may hold for cell-material and tissue-material interactions. The mechanical properties of individual core-shell fibers were controlled by core-shell composition and structure. The individual fiber modulus correlated with the increase in percent core size ranging from 0.55±0.10GPa to 1.74±0.22GPa and 0.48±0.12GPa to 1.53±0.12GPa for the PEKK-PCL and gelatin-PCL fibers, respectively. More importantly, it was demonstrated that mechanical properties of the scaffolds at the macroscale were dominantly determined by porosity under compression. The increase of scaffold porosity from 70.2%±1.0% to 93.2%±0.5% by increasing the core size in the PEKK-PCL scaffold resulted in the decrease of the compressive elastic modulus from 227.67±20.39kPa to 14.55±1.43kPa while a greater changes in the porosity of gelatin-PCL scaffold from 54.5%±4.2% to 89.6%±0.4% resulted in the compressive elastic modulus change from 484.01±30.18kPa to 17.57±1.40kPa. On the other hand, the biphasic behaviors under tensile mechanical loading result in a range from a minimum of 5.42±1.05MPa to a maximum

  16. Microstructure-dependent mechanical properties of electrospun core-shell scaffolds at multi-scale levels.

    PubMed

    Horner, Christopher B; Ico, Gerardo; Johnson, Jed; Zhao, Yi; Nam, Jin

    2016-06-01

    Mechanical factors among many physiochemical properties of scaffolds for stem cell-based tissue engineering significantly affect tissue morphogenesis by controlling stem cell behaviors including proliferation and phenotype-specific differentiation. Core-shell electrospinning provides a unique opportunity to control mechanical properties of scaffolds independent of surface chemistry, rendering a greater freedom to tailor design for specific applications. In this study, we synthesized electrospun core-shell scaffolds having different core composition and/or core-to-shell dimensional ratios. Two independent biocompatible polymer systems, polyetherketoneketone (PEKK) and gelatin as the core materials while maintaining the shell polymer with polycaprolactone (PCL), were utilized. The mechanics of such scaffolds was analyzed at the microscale and macroscales to determine the potential implications it may hold for cell-material and tissue-material interactions. The mechanical properties of individual core-shell fibers were controlled by core-shell composition and structure. The individual fiber modulus correlated with the increase in percent core size ranging from 0.55±0.10GPa to 1.74±0.22GPa and 0.48±0.12GPa to 1.53±0.12GPa for the PEKK-PCL and gelatin-PCL fibers, respectively. More importantly, it was demonstrated that mechanical properties of the scaffolds at the macroscale were dominantly determined by porosity under compression. The increase of scaffold porosity from 70.2%±1.0% to 93.2%±0.5% by increasing the core size in the PEKK-PCL scaffold resulted in the decrease of the compressive elastic modulus from 227.67±20.39kPa to 14.55±1.43kPa while a greater changes in the porosity of gelatin-PCL scaffold from 54.5%±4.2% to 89.6%±0.4% resulted in the compressive elastic modulus change from 484.01±30.18kPa to 17.57±1.40kPa. On the other hand, the biphasic behaviors under tensile mechanical loading result in a range from a minimum of 5.42±1.05MPa to a maximum

  17. Dimensional regularization is generic

    NASA Astrophysics Data System (ADS)

    Fujikawa, Kazuo

    2016-09-01

    The absence of the quadratic divergence in the Higgs sector of the Standard Model in the dimensional regularization is usually regarded to be an exceptional property of a specific regularization. To understand what is going on in the dimensional regularization, we illustrate how to reproduce the results of the dimensional regularization for the λϕ4 theory in the more conventional regularization such as the higher derivative regularization; the basic postulate involved is that the quadratically divergent induced mass, which is independent of the scale change of the physical mass, is kinematical and unphysical. This is consistent with the derivation of the Callan-Symanzik equation, which is a comparison of two theories with slightly different masses, for the λϕ4 theory without encountering the quadratic divergence. In this sense the dimensional regularization may be said to be generic in a bottom-up approach starting with a successful low energy theory. We also define a modified version of the mass independent renormalization for a scalar field which leads to the homogeneous renormalization group equation. Implications of the present analysis on the Standard Model at high energies and the presence or absence of SUSY at LHC energies are briefly discussed.

  18. Generic file format

    NASA Astrophysics Data System (ADS)

    Felgate, Nick

    2002-11-01

    The Generic File Format (GFF) is a file format developed within the UK ASW community for the interchange and storage of underwater sonar data. Originally developed for the interchange of time-series data between analysis systems, it has been extended to provide for storage of processed acoustic data (e.g., power and DEMON spectrum, lofargram grey-scale), nonacoustic data (e.g., own-ship dynamics, sensor configuration) and event data (e.g., tracker output, sonar intercepts). The format employs the chunk concept, as used in the WAV and AIFF file formats, to provide extendability (including local variants) while providing a measure of backward compatability. However, the basic concept has been adapted to allow for the mixing in the one file of multiple channels of different sample-rates and data-types through the inclusion of a data frame concept and multiple data blocks. Chunk cross-referencing has been employed to ensure data consistency. A provision is made in the header of the file to store details of the sensor and processing for the data (e.g., the number of hydrophones, beam direction, FFT size) so that an analysis system does not need to know about the sensor or other system from which the data originated.

  19. Tree ring and ice core time scales around the Santorini eruption

    NASA Astrophysics Data System (ADS)

    Löfroth, Elin; Muscheler, Raimund; Aldahan, Ala; Possnert, Göran; Berggren, Ann-Marie

    2010-05-01

    When studying cosmogenic radionuclides in ice core and tree ring archives around the Santorini eruption a ~20 year discrepancy was found between the records (Muscheler 2009). In this study a new 10Be dataset from the NGRIP ice core is presented. It has a resolution of 7 years and spans the period 3752-3244 BP (1803-1295 BC). The NGRIP 10Be record and the previously published 10Be GRIP record were compared to the IntCal datasets to further investigate the discrepancy between the ice core and tree ring chronologies. By modelling the 14C production rate based on atmospheric 14C records a comparison could be made to the 10Be flux which is assumed to represent the 10Be production rate. This showed a time shift of ~23 years between the records. The sensitivity of the results to changes in important model parameters was evaluated. Uncertainties in the carbon cycle model cannot explain a substantial part of the timing differences. Potential influences of climate and atmospheric processes on the 10Be deposition were studied using δ18O from the respective cores and GISP2 ice core ion data. The comparison to δ18O revealed a small but significant correlation between 10Be flux and δ18O when the 14C-derived production signal was removed from the 10Be curves. The ion data, as proxies for atmospheric circulation changes, did not show any correlations to the 10Be record or the 10Be/14C difference. When including possible data uncertainties there is still a minimum discrepancy of ~10 years between the 10Be ice core and the 14C tree ring record. Due to lack of alternative explanations it is concluded that the ice core and/or the tree ring chronologies contains unaccounted errors in this range. This also reconciles the radiocarbon 1627-1600 BC (Friedrich et al., 2006) and ice core 1642±5 BC (Vinther et al., 2006) datings of the Santorini eruption. Friedrich, W.L., Kromer, B., Friedrich, M., Heinemeier, J., Pfeiffer, T., & Talamo, S., 2006: Santorini eruption radiocarbon dated to

  20. Scaling to 150K cores: recent algorithm and performance engineering developments enabling XGC1 to run at scale

    SciTech Connect

    Mark F. Adams; Seung-Hoe Ku; Patrick Worley; Ed D'Azevedo; Julian C. Cummings; C.S. Chang

    2009-10-01

    Particle-in-cell (PIC) methods have proven to be eft#11;ective in discretizing the Vlasov-Maxwell system of equations describing the core of toroidal burning plasmas for many decades. Recent physical understanding of the importance of edge physics for stability and transport in tokamaks has lead to development of the fi#12;rst fully toroidal edge PIC code - XGC1. The edge region poses special problems in meshing for PIC methods due to the lack of closed flux surfaces, which makes fi#12;eld-line following meshes and coordinate systems problematic. We present a solution to this problem with a semi-#12;field line following mesh method in a cylindrical coordinate system. Additionally, modern supercomputers require highly concurrent algorithms and implementations, with all levels of the memory hierarchy being effe#14;ciently utilized to realize optimal code performance. This paper presents a mesh and particle partitioning method, suitable to our meshing strategy, for use on highly concurrent cache-based computing platforms.

  1. Acoustic Source Localization via Distributed Sensor Networks using Tera-scale Optical-Core Devices

    SciTech Connect

    Imam, Neena; Barhen, Jacob; Wardlaw, Michael

    2008-01-01

    For real-time acoustic source localization applications, one of the primary challenges is the considerable growth in computational complexity associated with the emergence of ever larger, active or passive, distributed sensor networks. The complexity of the calculations needed to achieve accurate source localization increases dramatically with the size of sensor arrays, resulting in substantial growth of computational requirements that cannot be met with standard hardware. One option to meet this challenge builds upon the emergence of digital optical-core devices. The objective of this work was to explore the implementation of key building block algorithms used in underwater source localization on an optical-core digital processing platform recently introduced by Lenslet Inc. They investigate key concepts of threat-detection algorithms such as Time Difference Of Arrival (TDOA) estimation via sensor data correlation in the time domain with the purpose of implementation on the optical-core processor. they illustrate their results with the aid of numerical simulation and actual optical hardware runs. The major accomplishments of this research, in terms of computational speedup and numerical accurcy achieved via the deployment of optical processing technology, should be of substantial interest to the acoustic signal processing community.

  2. A scaling study of the natural circulation flow of the ex-vessel core catcher cooling system of EU-APR1400 for designing a scale-down test facility for design verification

    SciTech Connect

    Rhee, B. W.; Ha, K. S.; Park, R. J.; Song, J. H.; Revankar, S. T.

    2012-07-01

    In this paper a scaling study on the steady state natural circulation flow along the flow path of the ex vessel core catcher cooling system of EU-APR1400 is described, and the scaling criteria for reproducing the same steady state thermalhydraulic characteristics of the natural circulation flow as a prototype core catcher cooling system in the scale-down test facility are derived in terms of the down-comer pipe diameter and orifice resistance. (authors)

  3. Space Generic Open Avionics Architecture (SGOAA): Overview

    NASA Technical Reports Server (NTRS)

    Wray, Richard B.; Stovall, John R.

    1992-01-01

    A space generic open avionics architecture created for NASA is described. It will serve as the basis for entities in spacecraft core avionics, capable of being tailored by NASA for future space program avionics ranging from small vehicles such as Moon ascent/descent vehicles to large ones such as Mars transfer vehicles or orbiting stations. The standard consists of: (1) a system architecture; (2) a generic processing hardware architecture; (3) a six class architecture interface model; (4) a system services functional subsystem architectural model; and (5) an operations control functional subsystem architectural model.

  4. Space Generic Open Avionics Architecture (SGOAA) standard specification

    NASA Technical Reports Server (NTRS)

    Wray, Richard B.; Stovall, John R.

    1994-01-01

    This standard establishes the Space Generic Open Avionics Architecture (SGOAA). The SGOAA includes a generic functional model, processing structural model, and an architecture interface model. This standard defines the requirements for applying these models to the development of spacecraft core avionics systems. The purpose of this standard is to provide an umbrella set of requirements for applying the generic architecture models to the design of a specific avionics hardware/software processing system. This standard defines a generic set of system interface points to facilitate identification of critical services and interfaces. It establishes the requirement for applying appropriate low level detailed implementation standards to those interfaces points. The generic core avionics functions and processing structural models provided herein are robustly tailorable to specific system applications and provide a platform upon which the interface model is to be applied.

  5. Space Generic Open Avionics Architecture (SGOAA) reference model technical guide

    NASA Technical Reports Server (NTRS)

    Wray, Richard B.; Stovall, John R.

    1993-01-01

    This report presents a full description of the Space Generic Open Avionics Architecture (SGOAA). The SGOAA consists of a generic system architecture for the entities in spacecraft avionics, a generic processing architecture, and a six class model of interfaces in a hardware/software system. The purpose of the SGOAA is to provide an umbrella set of requirements for applying the generic architecture interface model to the design of specific avionics hardware/software systems. The SGOAA defines a generic set of system interface points to facilitate identification of critical interfaces and establishes the requirements for applying appropriate low level detailed implementation standards to those interface points. The generic core avionics system and processing architecture models provided herein are robustly tailorable to specific system applications and provide a platform upon which the interface model is to be applied.

  6. Product, generic, and random generic quantum satisfiability

    SciTech Connect

    Laumann, C. R.; Sondhi, S. L.; Laeuchli, A. M.; Moessner, R.; Scardicchio, A.

    2010-06-15

    We report a cluster of results on k-QSAT, the problem of quantum satisfiability for k-qubit projectors which generalizes classical satisfiability with k-bit clauses to the quantum setting. First we define the NP-complete problem of product satisfiability and give a geometrical criterion for deciding when a QSAT interaction graph is product satisfiable with positive probability. We show that the same criterion suffices to establish quantum satisfiability for all projectors. Second, we apply these results to the random graph ensemble with generic projectors and obtain improved lower bounds on the location of the SAT-unSAT transition. Third, we present numerical results on random, generic satisfiability which provide estimates for the location of the transition for k=3 and k=4 and mild evidence for the existence of a phase which is satisfiable by entangled states alone.

  7. The radial scale length of turbulent fluctuations in the main core of TFTR plasmas

    SciTech Connect

    Mazzucato, E.; Nazikian, R.

    1993-07-01

    A new theory of microwave reflectometry in tokamaks has been developed which accounts for all the major characteristics of waves reflected from strong fluctuations near the cutoff layer. The theory has been used for studying the turbulence in the main core of neutral beam heated plasmas of the TFTR tokamak in the supershot regime. The results indicate that the radial correlation length of density fluctuations is a weak decreasing function of beam power, from [approximately]4 cm in Ohmic to [approx]2 cm at 14 MW of heating power. This corresponds to the range of wavelengths k[sub [perpendicular

  8. Mapping alteration minerals at prospect, outcrop and drill core scales using imaging spectrometry

    PubMed Central

    Kruse, Fred A.; L. Bedell, Richard; Taranik, James V.; Peppin, William A.; Weatherbee, Oliver; Calvin, Wendy M.

    2011-01-01

    Imaging spectrometer data (also known as ‘hyperspectral imagery’ or HSI) are well established for detailed mineral mapping from airborne and satellite systems. Overhead data, however, have substantial additional potential when used together with ground-based measurements. An imaging spectrometer system was used to acquire airborne measurements and to image in-place outcrops (mine walls) and boxed drill core and rock chips using modified sensor-mounting configurations. Data were acquired at 5 nm nominal spectral resolution in 360 channels from 0.4 to 2.45 μm. Analysis results using standardized hyperspectral methodologies demonstrate rapid extraction of representative mineral spectra and mapping of mineral distributions and abundances in map-plan, with core depth, and on the mine walls. The examples shown highlight the capabilities of these data for mineral mapping. Integration of these approaches promotes improved understanding of relations between geology, alteration and spectral signatures in three dimensions and should lead to improved efficiency of mine development, operations and ultimately effective mine closure. PMID:25937681

  9. Verification of the CENTRM Module for Adaptation of the SCALE Code to NGNP Prismatic and PBR Core Designs

    SciTech Connect

    Ganapol, Barry; Maldonado, Ivan

    2014-01-23

    The generation of multigroup cross sections lies at the heart of the very high temperature reactor (VHTR) core design, whether the prismatic (block) or pebble-bed type. The design process, generally performed in three steps, is quite involved and its execution is crucial to proper reactor physics analyses. The primary purpose of this project is to develop the CENTRM cross-section processing module of the SCALE code package for application to prismatic or pebble-bed core designs. The team will include a detailed outline of the entire processing procedure for application of CENTRM in a final report complete with demonstration. In addition, they will conduct a thorough verification of the CENTRM code, which has yet to be performed. The tasks for this project are to: Thoroughly test the panel algorithm for neutron slowing down; Develop the panel algorithm for multi-materials; Establish a multigroup convergence 1D transport acceleration algorithm in the panel formalism; Verify CENTRM in 1D plane geometry; Create and test the corresponding transport/panel algorithm in spherical and cylindrical geometries; and, Apply the verified CENTRM code to current VHTR core design configurations for an infinite lattice, including assessing effectiveness of Dancoff corrections to simulate TRISO particle heterogeneity.

  10. Static and dynamic adsorption of phosphonate and polymeric scale inhibitors onto reservoir core from laboratory tests to field application

    SciTech Connect

    Jordan, M.M.; Sorbie, K.S.; Yuan, M.D.; Taylor, K.; Hourston, K.E.; Ramstad, K.; Griffin, P.

    1995-11-01

    In this paper, results from static tests have been used to establish scale inhibitor adsorption mechanisms and levels in consolidated reservoir cores and to rank inhibitors for their adsorption behavior and, in some cases, squeeze return lifetimes. The purpose of this rapid and simple type of bulk adsorption measurement is to assist in the selection of inhibitors for further coreflooding which should be carried out on a minimum number of inhibitors. A bulk adsorption sensitivity study can be carried out very rapidly compared with carefully carried out reservoir condition core floods. The value of such rapid screening tests is evident although the authors show that it is not always possible for all factors concerning squeeze lifetime to be determined in this way. It is still often necessary to carry out a much smaller number of reservoir condition core floods for a few (usually between 1 and 3) selected inhibitor products. This is necessary if the dynamic adsorption isotherm, {Gamma}(C), is to be derived in order to develop the ``Field Squeeze Strategy`` or for the assessment of formation damage which might occur in the squeeze treatment. A field example of this is presented briefly in this paper although details can be found elsewhere.

  11. Scaled up low-mass star formation in massive star-forming cores in the G333 giant molecular cloud

    NASA Astrophysics Data System (ADS)

    Wiles, B.; Lo, N.; Redman, M. P.; Cunningham, M. R.; Jones, P. A.; Burton, M. G.; Bronfman, L.

    2016-06-01

    Three bright molecular line sources in G333 have recently been shown to exhibit signatures of infall. We describe a molecular line radiative transfer (RT) modelling process which is required to extract the infall signature from Mopra and Nanten2 data. The observed line profiles differ greatly between individual sources but are reproduced well by variations upon a common unified model where the outflow viewing angle is the most significant difference between the sources. The models and data together suggest that the observed properties of the high-mass star-forming regions such as infall, turbulence and mass are consistent with scaled-up versions of the low-mass case with turbulent velocities that are supersonic and an order of magnitude larger than those found in low-mass star-forming regions. Using detailed RT modelling, we show that the G333 cores are essentially undergoing a scaled-up version of low-mass star formation. This is an extension of earlier work in that the degree of infall and the chemical abundances are constrained by the RT modelling in a way that is not practical with a standard analysis of observational data. We also find high velocity infall and high infall mass rates, possibly suggesting accelerated collapse due to external pressure. Molecular depletion due to freeze-out on to dust grains in central regions of the cores is suggested by low molecular abundances of several species. Strong evidence for a local enhancement of 13C-bearing species towards the outflow cloud cores is discussed, consistent with the presence of shocks caused by the supersonic motions within them.

  12. The taxonomy of the Japanese oak red scale insect, Kuwania quercus (Kuwana) (Hemiptera: Coccoidea: Kuwaniidae), with a generic diagnosis, a key to species and description of a new species from California.

    PubMed

    San'An, Wu; Nan, Nan; Gullan, Penny; Deng, Jun

    2013-01-01

    The oak red scale insect, Kuwania quercus (Kuwana), was described from specimens collected from the bark of oak trees (Quercus species) in Japan. More recently, the species has been identified from California and China, but Californian specimens differ morphologically from Japanese material and are considered here to be a new species based on both morphological and molecular data. In this paper, an illustrated redescription of K. quercus is provided based on type specimens consisting of adult females, first-instar nymphs and intermediate-stage females, and a lectotype is designated for Sasakia quercus Kuwana. The new Californian species, Kuwania raygilli Wu & Gullan, is described and illustrated based on the adult female, first-instar nymph and intermediate-stage female. A new generic diagnosis for Kuwania Cockerell based on adult females and first-instar nymphs, and a key to species based on adult females are included.

  13. The radial scale length of turbulent fluctuations in the main core of TFTR plasmas

    SciTech Connect

    Mazzucato, E.; Nazikian, R.

    1993-07-01

    A new theory of microwave reflectometry in tokamaks has been developed which accounts for all the major characteristics of waves reflected from strong fluctuations near the cutoff layer. The theory has been used for studying the turbulence in the main core of neutral beam heated plasmas of the TFTR tokamak in the supershot regime. The results indicate that the radial correlation length of density fluctuations is a weak decreasing function of beam power, from {approx}4 cm in Ohmic to {approx}2 cm at 14 MW of heating power. This corresponds to the range of wavelengths k{sub {perpendicular}}{rho}{sub i}{approx}0.1--0.3. Over the same interval of heating powers, the level of density fluctuations is observed to steadily increase with beam power by more than an order of magnitude. This trend is inconsistent with mixing length estimates of the fluctuation level.

  14. Generic data modeling for clinical repositories.

    PubMed Central

    Johnson, S B

    1996-01-01

    OBJECTIVE: To construct a large-scale clinical repository that accurately captures a detailed understanding of the data vital to the process of health care and that provides highly efficient access to patient information for the users of a clinical information system. DESIGN: Conventional approaches to data modeling encourage the development of a highly specific data schema in order to capture as much information as possible about a given domain. In contrast, current database technology functions most effectively for clinical databases when a generic data schema is used. The technique of "generic data modeling" is presented as a method of reconciling these opposing views of clinical data, using formal operations to transform a detailed schema into a generic one. RESULTS: A complex schema consisting of hundreds of entities and representing a rich set of constraints about the patient care domain is transformed into a generic schema consisting of roughly two dozen tables. The resulting database design is efficient for patient-oriented queries and is highly flexible in adapting to the changing information needs of a health care institution, particularly changes involving the collection of new data elements. CONCLUSION: Conventional approaches to data modeling can be used to develop rich, complex models of clinical data that are useful for understanding and managing the process of patient care. Generic data modeling techniques can successfully transform a detailed design into an efficient generic design that is flexible enough to meet the needs of an operational clinical information system. PMID:8880680

  15. Core-scale electrical resistivity tomography (ERT) monitoring of CO2-brine mixture in Fontainebleau sandstone

    NASA Astrophysics Data System (ADS)

    Bosch, David; Ledo, Juanjo; Queralt, Pilar; Bellmunt, Fabian; Luquot, Linda; Gouze, Philippe

    2016-07-01

    The main goal of the monitoring stage of Carbon Capture and Storage (CCS) is to obtain an accurate estimation of the subsurface CO2 accumulation and to detect any possible leakage. Laboratory experiments are necessary to investigate the small scale processes governing the CO2-brine-rock interaction. They also provide a means to calibrate the results coming from field scale geophysical methods. In this work we set up an experimental system which is able to perform Electrical Resistivity Tomography (ERT) measurements on centimeter-scale rock samples at various P-T conditions. We present the results of two new experiments related to CO2 monitoring, performed on a cylindrical (4 × 8 cm) Fontainebleau rock sample. In the first one, we have quantified the CO2 saturation at different volume fractions, representing zones from a deep saline aquifer with varying degrees of saturation. In the second one, we have monitored and quantified the effect of CO2 dissolution in the brine at a pressure of 40 bar during eight days, emulating the invasion of CO2 into a shallow aquifer. Results highlight the importance of accounting for the contribution of surface conductivity in highly CO2-saturated regions, even in clay-free rocks, and also for brine conductivity variation due to CO2 dissolution. Ignoring any of these effects will end up in a CO2 saturation underestimation. We present a modified CO2 saturation equation to account for these two influences.

  16. Generic POCC architectures

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This document describes a generic POCC (Payload Operations Control Center) architecture based upon current POCC software practice, and several refinements to the architecture based upon object-oriented design principles and expected developments in teleoperations. The current-technology generic architecture is an abstraction based upon close analysis of the ERBS, COBE, and GRO POCC's. A series of three refinements is presented: these may be viewed as an approach to a phased transition to the recommended architecture. The third refinement constitutes the recommended architecture, which, together with associated rationales, will form the basis of the rapid synthesis environment to be developed in the remainder of this task. The document is organized into two parts. The first part describes the current generic architecture using several graphical as well as tabular representations or 'views.' The second part presents an analysis of the generic architecture in terms of object-oriented principles. On the basis of this discussion, refinements to the generic architecture are presented, again using a combination of graphical and tabular representations.

  17. Interpreting DNAPL saturations in a laboratory-scale injection with GPR data and direct core measurements

    USGS Publications Warehouse

    Johnson, Raymond H.; Poeter, Eileen P.

    2003-01-01

    Ground penetrating radar (GPR) is used to track a dense non-aqueous phase liquid (DNAPL) injection in a laboratory sand tank. Before data reduction, GPR data provide a qualitative measure of DNAPL saturation and movement. One-dimensional (1D) GPR modeling provides a quantitative interpretation of DNAPL volume within a given thickness during and after the injection. This is confirmed qualitatively by visual inspection of cores and two-dimensional GPR modeling. DNAPL saturation in sub-layers of that thickness could not be quantified because calibration of the 1D GPR model is non-unique when both permittivity and depth of multiple layers are unknown. Accurate quantitative interpretation of DNAPL volumes using 1D GPR modeling requires: 1) identification of a suitable target that produces a strong reflection and is not subject to any multidimensional interference; 2) knowledge of the exact depth of that target; and 3) use of two-way radar-wave travel times through the medium to the target to determine the permittivity of the intervening material, which eliminates reliance upon reflection amplitude. With geologic conditions that are suitable for GPR surveys (i.e., shallow depths and low electrical conductivities), the procedures in this laboratory study can be adapted to a field site to identify DNAPL source zones after a release has occurred.

  18. Accurate age scale of the Dome Fuji ice core, Antarctica from O2/N2 ratio of trapped air

    NASA Astrophysics Data System (ADS)

    Kawamura, K.; Aoki, S.; Nakazawa, T.; Suzuki, K.; Parrenin, F.

    2012-04-01

    Chronology of the first Dome Fuji deep ice core (core length: 2,500 m, ice thickness: 3,035 m) for the age range from 80 kyr to 340 kyr ago was established by orbital tuning of measured O2/N2 ratios in trapped air to local summer insolation, with precision better than about 2,000 years (Kawamura et al., 2007). The O2/N2 ratios found in polar ice cores are slightly lower than the atmospheric ratio because of size-dependent molecular fractionation during bubble close-off. The magnitude of this gas fractionation is believed to be governed by the magnitude of snow metamorphism when the layer was originally at the surface, which in turn is controlled by local summer insolation (Fujita et al., 2009). A strong advantage of the O2/N2 chronology is that there is no need to assume a lag between climatic records in the ice core and orbital forcings, becacuse O2/N2 ratios record local insolation through physical processes. Accuracy of the chronology was validated by comparing the O2/N2 chronology with U-Th radiometric chronology of speleothem records (Cheng et al., 2009) for the ends of Terminations II, III and IV, as well as several large climatic events, for which both ice-core CH4 and speleothem δ18O (a proxy for precipitation) show abrupt shifts as seen in the last glacial period. All ages from O2/N2 and U-Th chronology agreed with each other within ~2,000 yr. The O2/N2 chronology permits comparisons between Antarctic climate, greenhouse gases, astronomically calculated orbital parameters, and radiometrically-dated sea level and monsoon records. Here, we completed the measurements of O2/N2 ratios of the second Dome Fuji ice core, which reached bedrock, for the range from 2,400 to 3,028 m (320 - 700 kyr ago) at approximately 2,000-year time resolution. We made significant improvements in ice core storage practices and mass spectrometry. In particular, the ice core samples were stored at about -50 ° C until the air extraction, except during short periods of transportation

  19. Consistently dated records from three Greenland ice cores reveal regional millennial-scale isotope gradients with possible Heinrich Event imprint

    NASA Astrophysics Data System (ADS)

    Seierstad, Inger K.; Rasmussen, Sune O.

    2014-05-01

    We here present records from the NGRIP, GRIP and GISP2 ice cores tied to the same chronology for the past 104 ka at an unprecedented time resolution. The three ice cores have been linked by matching distinct peaks in volcanic proxy records and other impurity records from the three ice cores, assuming that these layers of elevated impurity content represent the same, instantaneous event in the past at all three sites. In total there are more than 900 identified marker horizons between the three cores including previously published match points, of which we introduce a minor revision. Our matching is independently confirmed by new and existing volcanic ash layers (tephra). The depth-depth relationship from the detailed matching is used to transfer the most recent and widely used Greenland ice core chronology, the GICC05modelext timescale, to the two Summit cores, GRIP and GISP2. Furthermore, we provide gas chronologies for the Summit cores that are consistent with the GICC05modelext timescale by utilizing both existing and new unpublished gas data. A comparison of the GICC05modelext and the former GISP2 timescale reveals major discrepancies in short time intervals during the glacial section. We detect a pronounced change in the relative annual layer thickness between the two Summit sites and NGRIP across the Last Glacial termination and early-to-mid Holocene, which can be explained by a relative accumulation increase at NGRIP compared to the Summit region as response to the onset of the Holocene and the climatic optimum. Between stadials and interstadials we infer that the accumulation contrast typically was nearly 10% greater at Summit compared to at NGRIP. The δ18O temperature-proxy records from NGRIP, GRIP and GISP2 are generally very similar and display a synchronous behavior at climate transitions, but the δ18O differences between Summit and NGRIP is slowly changing over the last glacial-interglacial cycle superimposed by abrupt millennial-to centennial scale

  20. Mid-Pleistocene Orbital and Millennial Scale Climate Change in a 200 ky lacustrine sediment core from SW North America

    NASA Astrophysics Data System (ADS)

    Fawcett, P. J.; Werne, J. P.; Anderson, R. S.; Heikoop, J. M.; Brown, E. T.; Berke, M. A.; Smith, S.; Goff, F. E.; Hurley, L. L.; Cisneros Dozal, L. M.; Schouten, S.; Sinninghe Damsté, J. S.; Huang, Y.; Toney, J. L.; Fessenden, J. E.; Woldegabriel, G. W.; Geissman, J. W.; Allen, C. D.

    2009-12-01

    How anthropogenic climate change will affect hydroclimate of the arid regions of SW North America over the next century is a concern. Model projections suggest permanent “dust bowl-like” conditions; however, any anthropogenic change will be superimposed on long-term natural climate variability. We use the paleoclimatic record from an 82-m deep lacustrine sediment core (VC-3) from the Valles Caldera, New Mexico to examine continental climate variations spanning two glacial cycles through the middle Pleistocene from MIS 14 to MIS 10 (552 ka to ~360 ka). Both orbital and millennial-scale variations are evident in multiple proxies, and a strong relationship occurs between the warmest temperatures in the record and periods of extended aridity. We suggest that these periods of aridity are characterized by decreased winter as well as summer precipitation amounts. A new group of organic geochemical proxies (MBT and CBT) allow us to reconstruct the annual mean air temperature (MAT) of the Valles Caldera watershed as well as the watershed soil pH down the length of the core. We compare these proxies to climatically sensitive pollen taxa and other core properties. The MAT record of VC-3 shows considerable glacial-interglacial variation and significant variability within individual glacial and interglacial periods. The warmest interglacial MATs (5 to 7°C) compare favorably with modern MATs of ~5°C in the Valle Grande. MIS 11 has three warm substages, based on MAT estimates (2°C warmer than the cool substages), warm (Juniperus, Quercus, Rosaceae) vs. cool (Abies, Picea, Artemisia) pollen taxa and variation in aquatic productivity proxies (TOC, Si:Ti). The three warm substages of MIS 11 appear to correspond to the three precessional peaks that occur during this interval. Glacial MATs range from -5 to +2°C, with multiple millennial-scale temperature oscillations evident. Several of the interstadials show a distinct pattern of relatively slower temperature increases and

  1. The (mis)measurement of the Dark Triad Dirty Dozen: exploitation at the core of the scale

    PubMed Central

    Kajonius, Petri J.; Persson, Björn N.; Rosenberg, Patricia

    2016-01-01

    Background. The dark side of human character has been conceptualized in the Dark Triad Model: Machiavellianism, psychopathy, and narcissism. These three dark traits are often measured using single long instruments for each one of the traits. Nevertheless, there is a necessity of short and valid personality measures in psychological research. As an independent research group, we replicated the factor structure, convergent validity and item response for one of the most recent and widely used short measures to operationalize these malevolent traits, namely, Jonason’s Dark Triad Dirty Dozen. We aimed to expand the understanding of what the Dirty Dozen really captures because the mixed results on construct validity in previous research. Method. We used the largest sample to date to respond to the Dirty Dozen (N = 3,698). We firstly investigated the factor structure using Confirmatory Factor Analysis and an exploratory distribution analysis of the items in the Dirty Dozen. Secondly, using a sub-sample (n = 500) and correlation analyses, we investigated the Dirty Dozen dark traits convergent validity to Machiavellianism measured by the Mach-IV, psychopathy measured by Eysenck’s Personality Questionnaire Revised, narcissism using the Narcissism Personality Inventory, and both neuroticism and extraversion from the Eysenck’s questionnaire. Finally, besides these Classic Test Theory analyses, we analyzed the responses for each Dirty Dozen item using Item Response Theory (IRT). Results. The results confirmed previous findings of a bi-factor model fit: one latent core dark trait and three dark traits. All three Dirty Dozen traits had a striking bi-modal distribution, which might indicate unconcealed social undesirability with the items. The three Dirty Dozen traits did converge too, although not strongly, with the contiguous single Dark Triad scales (r between .41 and .49). The probabilities of filling out steps on the Dirty Dozen narcissism-items were much higher than on

  2. Generic robot architecture

    DOEpatents

    Bruemmer, David J [Idaho Falls, ID; Few, Douglas A [Idaho Falls, ID

    2010-09-21

    The present invention provides methods, computer readable media, and apparatuses for a generic robot architecture providing a framework that is easily portable to a variety of robot platforms and is configured to provide hardware abstractions, abstractions for generic robot attributes, environment abstractions, and robot behaviors. The generic robot architecture includes a hardware abstraction level and a robot abstraction level. The hardware abstraction level is configured for developing hardware abstractions that define, monitor, and control hardware modules available on a robot platform. The robot abstraction level is configured for defining robot attributes and provides a software framework for building robot behaviors from the robot attributes. Each of the robot attributes includes hardware information from at least one hardware abstraction. In addition, each robot attribute is configured to substantially isolate the robot behaviors from the at least one hardware abstraction.

  3. Generic Airspace Survey

    NASA Technical Reports Server (NTRS)

    Mogford, Richard H.; Bridges, Wayne; Gujarl, Vimmy; Lee, Paul U.; Preston, William

    2013-01-01

    This paper reports on an extension of generic airspace research to explore the amount of memorization and specialized skills required to manage sectors with specific characteristics or factors. Fifty-five retired controllers were given an electronic survey where they rated the amount of memorization or specialized skills needed for sixteen generic airspace factors. The results suggested similarities in the pattern of ratings between different areas of the US (East, Central, and West). The average of the ratings for each area also showed some differences between regions, with ratings being generally higher in the East area. All sixteen factors were rated as moderately to highly important and may be useful for future research on generic airspace, air traffic controller workload, etc.

  4. A large-scale dynamo and magnetoturbulence in rapidly rotating core-collapse supernovae.

    PubMed

    Mösta, Philipp; Ott, Christian D; Radice, David; Roberts, Luke F; Schnetter, Erik; Haas, Roland

    2015-12-17

    Magnetohydrodynamic turbulence is important in many high-energy astrophysical systems, where instabilities can amplify the local magnetic field over very short timescales. Specifically, the magnetorotational instability and dynamo action have been suggested as a mechanism for the growth of magnetar-strength magnetic fields (of 10(15) gauss and above) and for powering the explosion of a rotating massive star. Such stars are candidate progenitors of type Ic-bl hypernovae, which make up all supernovae that are connected to long γ-ray bursts. The magnetorotational instability has been studied with local high-resolution shearing-box simulations in three dimensions, and with global two-dimensional simulations, but it is not known whether turbulence driven by this instability can result in the creation of a large-scale, ordered and dynamically relevant field. Here we report results from global, three-dimensional, general-relativistic magnetohydrodynamic turbulence simulations. We show that hydromagnetic turbulence in rapidly rotating protoneutron stars produces an inverse cascade of energy. We find a large-scale, ordered toroidal field that is consistent with the formation of bipolar magnetorotationally driven outflows. Our results demonstrate that rapidly rotating massive stars are plausible progenitors for both type Ic-bl supernovae and long γ-ray bursts, and provide a viable mechanism for the formation of magnetars. Moreover, our findings suggest that rapidly rotating massive stars might lie behind potentially magnetar-powered superluminous supernovae. PMID:26618868

  5. A large-scale dynamo and magnetoturbulence in rapidly rotating core-collapse supernovae.

    PubMed

    Mösta, Philipp; Ott, Christian D; Radice, David; Roberts, Luke F; Schnetter, Erik; Haas, Roland

    2015-12-17

    Magnetohydrodynamic turbulence is important in many high-energy astrophysical systems, where instabilities can amplify the local magnetic field over very short timescales. Specifically, the magnetorotational instability and dynamo action have been suggested as a mechanism for the growth of magnetar-strength magnetic fields (of 10(15) gauss and above) and for powering the explosion of a rotating massive star. Such stars are candidate progenitors of type Ic-bl hypernovae, which make up all supernovae that are connected to long γ-ray bursts. The magnetorotational instability has been studied with local high-resolution shearing-box simulations in three dimensions, and with global two-dimensional simulations, but it is not known whether turbulence driven by this instability can result in the creation of a large-scale, ordered and dynamically relevant field. Here we report results from global, three-dimensional, general-relativistic magnetohydrodynamic turbulence simulations. We show that hydromagnetic turbulence in rapidly rotating protoneutron stars produces an inverse cascade of energy. We find a large-scale, ordered toroidal field that is consistent with the formation of bipolar magnetorotationally driven outflows. Our results demonstrate that rapidly rotating massive stars are plausible progenitors for both type Ic-bl supernovae and long γ-ray bursts, and provide a viable mechanism for the formation of magnetars. Moreover, our findings suggest that rapidly rotating massive stars might lie behind potentially magnetar-powered superluminous supernovae.

  6. A large-scale dynamo and magnetoturbulence in rapidly rotating core-collapse supernovae

    NASA Astrophysics Data System (ADS)

    Mösta, Philipp; Ott, Christian D.; Radice, David; Roberts, Luke F.; Schnetter, Erik; Haas, Roland

    2015-12-01

    Magnetohydrodynamic turbulence is important in many high-energy astrophysical systems, where instabilities can amplify the local magnetic field over very short timescales. Specifically, the magnetorotational instability and dynamo action have been suggested as a mechanism for the growth of magnetar-strength magnetic fields (of 1015 gauss and above) and for powering the explosion of a rotating massive star. Such stars are candidate progenitors of type Ic-bl hypernovae, which make up all supernovae that are connected to long γ-ray bursts. The magnetorotational instability has been studied with local high-resolution shearing-box simulations in three dimensions, and with global two-dimensional simulations, but it is not known whether turbulence driven by this instability can result in the creation of a large-scale, ordered and dynamically relevant field. Here we report results from global, three-dimensional, general-relativistic magnetohydrodynamic turbulence simulations. We show that hydromagnetic turbulence in rapidly rotating protoneutron stars produces an inverse cascade of energy. We find a large-scale, ordered toroidal field that is consistent with the formation of bipolar magnetorotationally driven outflows. Our results demonstrate that rapidly rotating massive stars are plausible progenitors for both type Ic-bl supernovae and long γ-ray bursts, and provide a viable mechanism for the formation of magnetars. Moreover, our findings suggest that rapidly rotating massive stars might lie behind potentially magnetar-powered superluminous supernovae.

  7. Generic Kalman Filter Software

    NASA Technical Reports Server (NTRS)

    Lisano, Michael E., II; Crues, Edwin Z.

    2005-01-01

    The Generic Kalman Filter (GKF) software provides a standard basis for the development of application-specific Kalman-filter programs. Historically, Kalman filters have been implemented by customized programs that must be written, coded, and debugged anew for each unique application, then tested and tuned with simulated or actual measurement data. Total development times for typical Kalman-filter application programs have ranged from months to weeks. The GKF software can simplify the development process and reduce the development time by eliminating the need to re-create the fundamental implementation of the Kalman filter for each new application. The GKF software is written in the ANSI C programming language. It contains a generic Kalman-filter-development directory that, in turn, contains a code for a generic Kalman filter function; more specifically, it contains a generically designed and generically coded implementation of linear, linearized, and extended Kalman filtering algorithms, including algorithms for state- and covariance-update and -propagation functions. The mathematical theory that underlies the algorithms is well known and has been reported extensively in the open technical literature. Also contained in the directory are a header file that defines generic Kalman-filter data structures and prototype functions and template versions of application-specific subfunction and calling navigation/estimation routine code and headers. Once the user has provided a calling routine and the required application-specific subfunctions, the application-specific Kalman-filter software can be compiled and executed immediately. During execution, the generic Kalman-filter function is called from a higher-level navigation or estimation routine that preprocesses measurement data and post-processes output data. The generic Kalman-filter function uses the aforementioned data structures and five implementation- specific subfunctions, which have been developed by the user on

  8. Narrow Scale Flow and a Weak Field by the Top of Earth's Core: Evidence from Orsted, Magsat and Secular Variation

    NASA Technical Reports Server (NTRS)

    Voorhies, Coerte V.

    2004-01-01

    As Earth's main magnetic field weakens, our magnetic shield against the onslaught of the solar wind thins. And the field strength needed to fend off battering by solar coronal mass ejections is decreasing, just when the delicate complexity of modem, vulnerable, electro-technological systems is increasing at an unprecedented rate. Recently, a working group of distinguished scientist from across the nation has asked NASA's Solid Earth and Natural Hazards program a key question: What are the dynamics of Earth s magnetic field and its interactions with the Earth system? Paleomagnetic studies of crustal rocks magnetized in the geologic past reveal that polarity reversals have occurred many times during Earth s history. Networked super-computer simulations of core field and flow, including effects of gravitational, pressure, rotational Coriolis, magnetic and viscous forces, suggest how this might happen in detail. And space-based measurements of the real, time-varying magnetic field help constrain estimates of the speed and direction of fluid iron flowing near the top of the core and enable tests of some hypotheses about such flow. Now scientists at NASA s Goddard Space Flight Center have developed and applied methods to test the hypotheses of narrow scale flow and of a dynamically weak magnetic field near the top of Earth s core. Using two completely different methods, C. V. Voorhies has shown these hypotheses lead to specific theoretical forms for the "spectrum" of Earth s main magnetic field and the spectrum of its rate of change. Much as solar physicists use a prism to separate sunlight into its spectrum, from long wavelength red to short wavelength blue light, geophysicists use a digital prism, spherical harmonic analysis, to separate the measured geomagnetic field into its spectrum, from long to short wavelength fields. They do this for the rate of change of the field as well.

  9. Modeling of Viscoelastic Properties of Porous Rocks Saturated with Viscous Fluid at Seismic Frequencies at the Core Scale

    NASA Astrophysics Data System (ADS)

    Schmitt, D. R.; Wang, Z.; Wang, F.; Wang, R.

    2015-12-01

    Currently the moduli and velocities of rocks at seismic frequencies are usually measured by the strain-stress method in lab. However, such measurements require well-designed equipment and skilled technicians, which greatly hinders the experimental investigation on the elastic and visco-elastic properties of rocks at seismic frequencies. We attempt to model the dynamic moduli of porous rocks saturated with viscous fluid at seismic frequencies on core scale using the strain-stress method, aiming to provide a complement to real core measurements in lab. First, we build 2D geometrical models containing the pore structure information of porous rocks based on the digital images (such as thin section, SEM, CT, etc.) of real rocks. Then we assume the rock frames are linearly elastic, and use the standard Maxwell spring-dash pot model to describe the visco-elastic properties of pore fluids. Boundary conditions are set according to the strain-stress method; and the displacement field is calculated using the finite element method (FEM). We numerically test the effects of fluid viscosity, frequency, and pore structure on the visco-elastic properties based on the calculation results. In our modeling, the viscosity of the pore fluid ranges from 103mPas to 109mPas; and the frequency varies from 5Hz to 500Hz. The preliminary results indicate that the saturated rock behaves stiffer and shows larger phase lag between stress and strain when the viscosity of the pore fluid and (or) the frequency increase.

  10. Internal stresses in pre-stressed micron-scale aluminum core-shell particles and their improved reactivity

    SciTech Connect

    Levitas, Valery I.; McCollum, Jena; Pantoya, Michelle L.; Tamura, Nobumichi

    2015-09-07

    Dilatation of aluminum (Al) core for micron-scale particles covered by alumina (Al{sub 2}O{sub 3}) shell was measured utilizing x-ray diffraction with synchrotron radiation for untreated particles and particles after annealing at 573 K and fast quenching at 0.46 K/s. Such a treatment led to the increase in flame rate for Al + CuO composite by 32% and is consistent with theoretical predictions based on the melt-dispersion mechanism of reaction for Al particles. Experimental results confirmed theoretical estimates and proved that the improvement of Al reactivity is due to internal stresses. This opens new ways of controlling particle reactivity through creating and monitoring internal stresses.

  11. Internal stresses in pre-stressed micron-scale aluminum core-shell particles and their improved reactivity

    NASA Astrophysics Data System (ADS)

    Levitas, Valery I.; McCollum, Jena; Pantoya, Michelle L.; Tamura, Nobumichi

    2015-09-01

    Dilatation of aluminum (Al) core for micron-scale particles covered by alumina (Al2O3) shell was measured utilizing x-ray diffraction with synchrotron radiation for untreated particles and particles after annealing at 573 K and fast quenching at 0.46 K/s. Such a treatment led to the increase in flame rate for Al + CuO composite by 32% and is consistent with theoretical predictions based on the melt-dispersion mechanism of reaction for Al particles. Experimental results confirmed theoretical estimates and proved that the improvement of Al reactivity is due to internal stresses. This opens new ways of controlling particle reactivity through creating and monitoring internal stresses.

  12. Superlinear scaling in master-slave quantum chemical calculations using in-core storage of two-electron integrals.

    PubMed

    Fossgård, Eirik; Ruud, Kenneth

    2006-02-01

    We describe the implementation of a parallel, in-core, integral-direct Hartree-Fock and density functional theory code for the efficient calculation of Hartree-Fock wave functions and density functional theory. The algorithm is based on a parallel master-slave algorithm, and the two-electron integrals calculated by a slave are stored in available local memory. To ensure the greatest computational savings, the master node keeps track of all integral batches stored on the different slaves. The code can reuse undifferentiated two-electron integrals both in the wave function optimization and in the evaluation of second-, third-, and fourth-order molecular properties. Superlinear scaling is achieved in a series of test examples, with speedups of up to 55 achieved for calculations run on medium-sized molecules on 16 processors with respect to the time used on a single processor.

  13. Large-scale boiling experiments of the flooded cavity concept for in-vessel core retention

    SciTech Connect

    Chu, T.Y.; Slezak, S.E.; Bentz, J.H.; Pasedag, W.F.

    1994-03-01

    This paper presents results of ex-vessel boiling experiments performed in the CYBL (CYlindrical BoiLing) facility. CYBL is a reactor-scale facility for confirmatory research of the flooded cavity concept for accident management. CYBL has a tank-within-a-tank design; the inner tank simulates the reactor vessel and the outer tank simulates the reactor cavity. Experiments with uniform and edge-peaked heat flux distributions up to 20 W/cm{sup 2} across the vessel bottom were performed. Boiling outside the reactor vessel was found to be subcooled nucleate boiling. The subcooling is mainly due to the gravity head which results from flooding the sides of the reactor vessel. The boiling process exhibits a cyclic pattern with four distinct phases: direct liquid/solid contact, bubble nucleation and growth, coalescence, and vapor mass dispersion (ejection). The results suggest that under prototypic heat load and heat flux distributions, the flooded cavity in a passive pressurized water reactor like the AP-600 should be capable of cooling the reactor pressure vessel in the central region of the lower head that is addressed by these tests.

  14. Generic telemetry processing

    NASA Technical Reports Server (NTRS)

    Pettit, Richard L., Jr.

    1988-01-01

    The Space Flight Operations Center (SFOC) is a generic suite of ground data systems software. One main subsystem of SFOC is the Telemetry Input Subsystem (TIS). Utilizing techniques for the abstract representation of data, the TIS has provided a flexible software base that can be used as a baseline for multiple spacecraft missions.

  15. Generic Sentences in English and French.

    ERIC Educational Resources Information Center

    Herschensohn, Julia

    Previous accounts of "generic" have been either too broad in including several sentence types as generic, or too narrow in limiting the definition of generic to the noun or verb alone. This research critically examines data and previous treatments of the generic verb, generic noun, and generic sentence. Because every generic sentence may also have…

  16. Model-data comparison of soil organic oatter cycling: soil core scale

    NASA Astrophysics Data System (ADS)

    Wutzler, Thomas; Reichstein, Markus

    2010-05-01

    Soil organic matter (SOM) cycling is usually modeled as a donor controlled process, most often by first order kinetics. However, evidence of contradition of this donor-paradigm is appearing. One alternative hypothesis is that microbiological consumers of SOM play an important role and need to be taken into account more explicitely. Here we link SOM cycling to the modeling of microbial growth kinetics. We set up a suite of alternative models of microbial growth. Explicitly modelling the cycling of a label across carbon pools allowed to compare the model outputs to data of a soil priming experiment. The experimental data was taken from U. Hamer, & B. Marschner (2002 Journal of Plant Nutrition and Soil Science 165(3)), who incubated several 14C labelled substrates at 20°C in a model system that consisted of sand mixed with lignin for 26 days. Data streams of time series total respiration, respiration from labelled amendment and prior information on model parameters were used to determine the posterior probability density function of the model parameters of each of the model variants and to calculate Bayes-Factors, the ratios of the likelihood of the different model variants. This kind of data and Bayesian analysis is usable to compare model structures adapted to processes that determine the dynamics at this scale: co-limitation of depolymerization of older soil organic matter by both substrate and decomposers, prefererrential substrate usage, activation and deactivation and predation of microbes, and usage of both assimilated carbon and carbon of internal pools for maintenance and growth respiration.

  17. Space Generic Open Avionics Architecture (SGOAA) standard specification

    NASA Technical Reports Server (NTRS)

    Wray, Richard B.; Stovall, John R.

    1993-01-01

    The purpose of this standard is to provide an umbrella set of requirements for applying the generic architecture interface model to the design of a specific avionics hardware/software system. This standard defines a generic set of system interface points to facilitate identification of critical interfaces and establishes the requirements for applying appropriate low level detailed implementation standards to those interface points. The generic core avionics system and processing architecture models provided herein are robustly tailorable to specific system applications and provide a platform upon which the interface model is to be applied.

  18. Simulating Fine-Scale Atmospheric Processes: A New Core Capability and its Application to Predicting Wildfire Behavior

    SciTech Connect

    Bradley, M M; Leach, M J; Molenkamp, C R; Hall, C H; Wilder, L; Neher, L A

    2003-02-07

    This LDRD project consisted of the development, testing, and prototype application of a new capability to couple atmospheric models of different spatial and temporal scales with a state-of-the-science vegetation-fuel combustion model and a GIs-based analysis system. The research addressed the complex, multi-scale interactions of atmospheric processes, combustion, and vegetative fuel conditions, using a suite of models to simulate their impact on wildfire behavior in areas of complex terrain. During the course of the project, we made substantial progress toward the implementation of a world-class modeling system that could be used as a tool for wildfire risk assessment, wildfire consequence analysis, wildfire suppression planning, fuels management, firefighter training, and public fire-safety education. With one additional year of funding we would have been able conduct combined modeling and field experiments to evaluate the models capability to predict the behavior of prescribed burns before they are ignited. Because of its investment in this LDRD project, LLNL is very close to having a new core capability--likely the world's most generally applicable, most scientifically sound, and most respected wildfire simulation system.

  19. On the extent of size range and power law scaling for particles of natural carbonate fault cores

    NASA Astrophysics Data System (ADS)

    Billi, Andrea

    2007-09-01

    To determine the size range and both type and extent of the scaling laws for particles of loose natural carbonate fault rocks, six granular fault cores from Mesozoic carbonate strata of central Italy were sampled. Particle size distributions of twelve samples were determined by combining sieving and sedimentation methods. Results show that, regardless of the fault geometry, kinematics, and tectonic history, the size of fault rock particles respects a power law distribution across approximately four orders of magnitude. The fractal dimension ( D) of the particle size distribution in the analysed samples ranges between ˜2.0 and ˜3.5. A lower bound to the power law trend is evident in all samples except in those with the highest D-values; in these samples, the smallest analysed particles (˜0.0005 mm in diameter) were also included in the power law interval, meaning that the lower size limit of the power law distribution decreases for increasing D-values and that smallest particles start to be comminuted with increasing strain (i.e. increasing fault displacement and D-values). For increasing D-values, also the largest particles tends to decrease in number, but this evidence may be affected by a censoring bias connected with the sample size. Stick-slip behaviour is suggested for the studied faults on the basis of the inferred particle size evolutions. Although further analyses are necessary to make the results of this study more generalizable, the preliminary definition of the scaling rules for fault rock particles may serve as a tool for predicting a large scale of fault rock particles once a limited range is known. In particular, data from this study may result useful as input numbers in numerical models addressing the packing of fault rock particles for frictional and hydraulic purposes.

  20. Small-scale disturbances in the stratigraphy of the NEEM ice core: observations and numerical model simulations

    NASA Astrophysics Data System (ADS)

    Jansen, D.; Llorens, M.-G.; Westhoff, J.; Steinbach, F.; Kipfstuhl, S.; Bons, P. D.; Griera, A.; Weikusat, I.

    2015-10-01

    Disturbances on the centimetre scale in the stratigraphy of the NEEM ice core (North Greenland) can be mapped by an optical line scanner as long as the ice does have a visual layering, such as, for example, cloudy bands. Different focal depths allow, to a certain extent, a three dimensional view of the structures. In this study we present a detailed analysis of the visible folds, discuss their characteristics and frequency and present examples of typical fold structures. We also analyse the structures with regard to the deformation boundary conditions under which they formed. The structures evolve from gentle waves at about 1500 m to overturned z-folds with increasing depth. Occasionally, the folding causes significant thickening of layers. Their similar-fold shape indicates that they are passive features and are probably not initiated by rheology differences between alternating layers. Layering is heavily disturbed and tracing of single layers is no longer possible below a depth of 2160 m. c-axes orientation distributions for the corresponding core sections were analysed where available in addition to visual stratigraphy. The data show axial-plane parallel strings of grains with c-axis orientations that deviate from that of the matrix, which shows a single-maximum fabric at the depth where the folding occurs. Numerical modelling of crystal viscoplasticity deformation and dynamic recrystallisation was used to improve the understanding of the formation of the observed structures during deformation. The modelling reproduces the development of bands of grains with a tilted orientation relative to the single maximum fabric of the matrix, and also the associated local deformation. We conclude from these results that the observed folding is a consequence of localized deformation at the boundaries of kink bands.

  1. Small-scale disturbances in the stratigraphy of the NEEM ice core: observations and numerical model simulations

    NASA Astrophysics Data System (ADS)

    Jansen, D.; Llorens, M.-G.; Westhoff, J.; Steinbach, F.; Kipfstuhl, S.; Bons, P. D.; Griera, A.; Weikusat, I.

    2016-02-01

    Disturbances on the centimetre scale in the stratigraphy of the North Greenland Eemian Ice Drilling (NEEM) ice core (North Greenland) can be mapped by an optical line scanner as long as the ice has visual layering, such as, for example, cloudy bands. Different focal depths allow, to a certain extent, a three-dimensional view of the structures. In this study we present a detailed analysis of the visible folds, discuss their characteristics and frequency, and present examples of typical fold structures. We also analyse the structures with regard to the deformation boundary conditions under which they formed. The structures evolve from gentle waves at about 1500 m to overturned z folds with increasing depth. Occasionally, the folding causes significant thickening of layers. Their similar fold shape indicates that they are passive features and are probably not initiated by rheology differences between alternating layers. Layering is heavily disturbed and tracing of single layers is no longer possible below a depth of 2160 m. C axes orientation distributions for the corresponding core sections were analysed, where available, in addition to visual stratigraphy. The data show axial-plane parallel strings of grains with c axis orientations that deviate from that of the matrix, which shows a single maximum fabric at the depth where the folding occurs. Numerical modelling of crystal viscoplastic deformation and dynamic recrystallisation was used to improve the understanding of the formation of the observed structures during deformation. The modelling reproduces the development of bands of grains with a tilted-lattice orientation relative to the single maximum fabric of the matrix, and also the associated local deformation. We conclude from these results that the observed folding can be explained by formation of these tilted-lattice bands.

  2. Higher fine-scale genetic structure in peripheral than in core populations of a long-lived and mixed-mating conifer - eastern white cedar (Thuja occidentalis L.)

    PubMed Central

    2012-01-01

    Background Fine-scale or spatial genetic structure (SGS) is one of the key genetic characteristics of plant populations. Several evolutionary and ecological processes and population characteristics influence the level of SGS within plant populations. Higher fine-scale genetic structure may be expected in peripheral than core populations of long-lived forest trees, owing to the differences in the magnitude of operating evolutionary and ecological forces such as gene flow, genetic drift, effective population size and founder effects. We addressed this question using eastern white cedar (Thuja occidentalis) as a model species for declining to endangered long-lived tree species with mixed-mating system. Results We determined the SGS in two core and two peripheral populations of eastern white cedar from its Maritime Canadian eastern range using six nuclear microsatellite DNA markers. Significant SGS ranging from 15 m to 75 m distance classes was observed in the four studied populations. An analysis of combined four populations revealed significant positive SGS up to the 45 m distance class. The mean positive significant SGS observed in the peripheral populations was up to six times (up to 90 m) of that observed in the core populations (15 m). Spatial autocorrelation coefficients and correlograms of single and sub-sets of populations were statistically significant. The extent of within-population SGS was significantly negatively correlated with all genetic diversity parameters. Significant heterogeneity of within-population SGS was observed for 0-15 m and 61-90 m between core and peripheral populations. Average Sp, and gene flow distances were higher in peripheral (Sp = 0.023, σg = 135 m) than in core (Sp = 0.014, σg = 109 m) populations. However, the mean neighborhood size was higher in the core (Nb = 82) than in the peripheral (Nb = 48) populations. Conclusion Eastern white cedar populations have significant fine-scale genetic structure at short distances. Peripheral

  3. Generics: keep a balanced view.

    PubMed

    2014-02-01

    Once the different kinds of commercial protection (patents, etc.) granted to the manufacturer of an "originator" drug have expired, the drug in question may be copied by other companies. These copies are known as generics. The characteristics and pharmaceutical quality of generics are governed by international standards. The marketing authorisation procedure for generic drugs dispenses with preclinical and clinical trials, which already exist for the originator drug. In contrast, proof of bioequivalence must be provided. In practice, this means demonstrating that the effects of the generic are similar (but not necessarily identical) to those of the originator drug. Slight differences between a generic and its brand-name counterpart are allowed, provided they do not markedly affect the efficacy or adverse effect profile in comparison to the originator drug. The accepted degree of difference between a generic and the original brand-name drug is the same as the acceptable difference between two batches of the originator drug. The rules governing generic manufacturing conditions are identical to those applying to originator drugs. And issues raised by drug production abroad, particularly to Asian countries, apply to originator just as much as to generic drugs. Generics represent a significant source of financial savings for society. In France, various measures have been introduced to encourage doctors, pharmacists and patients, respectively, to prescribe, dispense and use generics. Criticisms of the efficacy or quality of generics are often unfounded and sometimes deliberately orchestrated. Smear campaigns conducted by drug companies that market originator drugs, and also by some healthcare professionals, sow confusion, to the detriment of generic use. There is no tangible proof that generics are less safe than originator drugs, provided they are chosen wisely, taking into account factors such as their packaging quality. It is up to healthcare professionals to decide

  4. Grain-scale imaging and compositional characterization of cryo-preserved India NGHP 01 gas-hydrate-bearing cores

    USGS Publications Warehouse

    Stern, Laura A.; Lorenson, T.D.

    2014-01-01

    We report on grain-scale characteristics and gas analyses of gas-hydrate-bearing samples retrieved by NGHP Expedition 01 as part of a large-scale effort to study gas hydrate occurrences off the eastern-Indian Peninsula and along the Andaman convergent margin. Using cryogenic scanning electron microscopy, X-ray spectroscopy, and gas chromatography, we investigated gas hydrate grain morphology and distribution within sediments, gas hydrate composition, and methane isotopic composition of samples from Krishna–Godavari (KG) basin and Andaman back-arc basin borehole sites from depths ranging 26 to 525 mbsf. Gas hydrate in KG-basin samples commonly occurs as nodules or coarse veins with typical hydrate grain size of 30–80 μm, as small pods or thin veins 50 to several hundred microns in width, or disseminated in sediment. Nodules contain abundant and commonly isolated macropores, in some places suggesting the original presence of a free gas phase. Gas hydrate also occurs as faceted crystals lining the interiors of cavities. While these vug-like structures constitute a relatively minor mode of gas hydrate occurrence, they were observed in near-seafloor KG-basin samples as well as in those of deeper origin (>100 mbsf) and may be original formation features. Other samples exhibit gas hydrate grains rimmed by NaCl-bearing material, presumably produced by salt exclusion during original hydrate formation. Well-preserved microfossil and other biogenic detritus are also found within several samples, most abundantly in Andaman core material where gas hydrate fills microfossil crevices. The range of gas hydrate modes of occurrence observed in the full suite of samples suggests a range of formation processes were involved, as influenced by local in situconditions. The hydrate-forming gas is predominantly methane with trace quantities of higher molecular weight hydrocarbons of primarily microbial origin. The composition indicates the gas hydrate is Structure I.

  5. An out-of-core high-resolution FFT algorithm for determining large-scale imperfections of surface potentials in crystals

    NASA Astrophysics Data System (ADS)

    Bakhos, M.; Vincent, A. P.; Yuen, D. A.

    2005-06-01

    We present a simple out-of-core algorithm for computing the Fast-Fourier Transform (FFT) needed to determine the two-dimensional potential of surface crystals with large-scale features, like faults, at ultra-high resolution, with around 10 9 grid points. This algorithm represents a proof of concept that a simple and easy-to-code, out-of-core algorithm can be easily implemented and used to solve large-scale problems on low-cost hardware. The main novelties of our algorithm are: (1) elapsed and I/O times decrease with the number of single records (lines) being read; (2) only basic reading and writing routines is necessary for making the out-of-core access. Our method can be easily extended to 3D and be applied to many grand-challenge problems in science and engineering, such as fluid dynamics.

  6. Leveraging the power of multi-core platforms for large-scale geospatial data processing: Exemplified by generating DEM from massive LiDAR point clouds

    NASA Astrophysics Data System (ADS)

    Guan, Xuefeng; Wu, Huayi

    2010-10-01

    In recent years improvements in spatial data acquisition technologies, such as LiDAR, resulted in an explosive increase in the volume of spatial data, presenting unprecedented challenges for computation capacity. At the same time, the kernel of computing platforms the CPU, also evolved from a single-core to multi-core architecture. This radical change significantly affected existing data processing algorithms. Exemplified by the problem of generating DEM from massive air-borne LiDAR point clouds, this paper studies how to leverage the power of multi-core platforms for large-scale geospatial data processing and demonstrates how multi-core technologies can improve performance. Pipelining is adopted to exploit the thread level parallelism of multi-core platforms. First, raw point clouds are partitioned into overlapped blocks. Second, these discrete blocks are interpolated concurrently on parallel pipelines. On the interpolation run, intermediate results are sorted and finally merged into an integrated DEM. This parallelization demonstrates the great potential of multi-core platforms with high data throughput and low memory footprint. This approach achieves excellent performance speedup with greatly reduced processing time. For example, on a 2.0 GHz Quad-Core Intel Xeon platform, the proposed parallel approach can process approximately one billion LiDAR points (16.4 GB) in about 12 min and produces a 27,500×30,500 raster DEM, using less than 800 MB main memory.

  7. Narrow scale flow across a weak field by the top of Earth's core: evidence from Ørsted, Magsat,and SV

    NASA Astrophysics Data System (ADS)

    Voorhies, C.

    2003-04-01

    To test two geophysical hypotheses against observation, the Ørsted Initial Field Model [Olsen et al., 2000] is used to estimate the radius of Earth's core by spectral methods. The model coefficients are used to compute the mean square magnetic flux density in spherical harmonics of degree n on the reference sphere (radius a = 6371.2 km), which is an observational spectrum R(n). The theoretical spectrum tested, {R(n)} = K[(n+1/2)/(n(n+1))](c/a)**(2n+4), is obtained from the hypotheses of narrow scale flow across a dynamically weak magnetic field near the top of Earth's core. It describes a low degree, core-source magnetic energy range and is similar to spectra advanced by Stevenson [1983] and McLeod [1985, 1996]. Core radius c and amplitude K are estimated by fitting log-theoretical to log-observational spectra at low degrees. Estimates of c from R(n) at degrees 1 through N range between 3441 and 3542 km as N increases from 4 to 12. None of these estimates differ significantly from the seismologic core radius (3480 km). Significant differences do occur if N exceeds 12, which is consistent with appreciable non-core (crustal) source fields at degrees 13 and above, or if other spectral forms are assumed. Similar results are obtained from 1980 epoch Magsat models [Sabaka, Olsen &Langel, 2000, 2002; Cain et al., 1990; Langel, Estes &Mead, 1982]. One way to deduce {R(n)} uses the expected low degree spectrum for secular variation (SV) induced by narrow scale flow by the top of the core, {F(n)} = Cn(n+1/2)(n+1)(c/a)**(2n+4). The value of c obtained by fitting this form to the mean observational SV spectrum from model GSFC 9/80 is 3470 +/- 91 km, also in accord with seismologic estimates. This test of the kinematic narrow scale flow hypothesis is independent of the dynamic weak field hypothesis. The agreement between SV, Magsat, Ørsted and seismologic estimates of core radius means the hypotheses pass these tests. Analysis of some recent observational SV spectra, however

  8. Large-scale fabrication and application of magnetite coated Ag NW-core water-dispersible hybrid nanomaterials.

    PubMed

    Wang, Baoyu; Zhang, Min; Li, Weizhen; Wang, Linlin; Zheng, Jing; Gan, Wenjun; Xu, Jingli

    2015-05-01

    In this work, we report a large scale synthetic procedure that allows attachment of magnetite nanoparticles onto Ag NWs in situ, which was conducted in a triethylene glycol (TREG) solution with iron acetylacetonate and Ag NWs as starting materials. The as-prepared Ag NW/Fe3O4 NP composites are well characterized by SEM, TEM, XRD, XPS, FT-IR, and VSM techniques. It was found that the mass ratio of iron acetylacetonate to Ag NWs plays a crucial role in controlling the amount of magnetite nanoparticles decorated on the Ag NWs. The resulting Ag NW/Fe3O4 NP composites exhibit superparamagnetic properties at room temperature, and can be well dispersed in aqueous and organic solutions, which is greatly beneficial for their application and functionality. Thus, the as-prepared magnetic silver nanowires show good catalytic activity, using the catalytic reduction of methylene blue (MB) as a model reaction. Furthermore, the Ag NW/Fe3O4 NP composites can be functionalized with polydopamine (Pdop), resorcinol-formaldehyde resin (PFR), and SiO2, respectively, in aqueous/ethanol solution. Meanwhile they can also be coated with polyphosphazene (PZS) in organic solution, resulting in a unique nanocable with well-defined core shell structures. Besides, taking Ag NW/Fe3O4@SiO2 as an example, a hollow magnetic silica nanotube can be obtained with the use of Ag NWs as physical templates and a solution of ammonium and H2O2. These can greatly improve the application of the Ag NW/Fe3O4 NP composites. The as-synthesized above nanocomposites have high potential for applications in the fields of polymers, wastewater treatment, sensors, and biomaterials.

  9. Large-scale fabrication and application of magnetite coated Ag NW-core water-dispersible hybrid nanomaterials.

    PubMed

    Wang, Baoyu; Zhang, Min; Li, Weizhen; Wang, Linlin; Zheng, Jing; Gan, Wenjun; Xu, Jingli

    2015-05-01

    In this work, we report a large scale synthetic procedure that allows attachment of magnetite nanoparticles onto Ag NWs in situ, which was conducted in a triethylene glycol (TREG) solution with iron acetylacetonate and Ag NWs as starting materials. The as-prepared Ag NW/Fe3O4 NP composites are well characterized by SEM, TEM, XRD, XPS, FT-IR, and VSM techniques. It was found that the mass ratio of iron acetylacetonate to Ag NWs plays a crucial role in controlling the amount of magnetite nanoparticles decorated on the Ag NWs. The resulting Ag NW/Fe3O4 NP composites exhibit superparamagnetic properties at room temperature, and can be well dispersed in aqueous and organic solutions, which is greatly beneficial for their application and functionality. Thus, the as-prepared magnetic silver nanowires show good catalytic activity, using the catalytic reduction of methylene blue (MB) as a model reaction. Furthermore, the Ag NW/Fe3O4 NP composites can be functionalized with polydopamine (Pdop), resorcinol-formaldehyde resin (PFR), and SiO2, respectively, in aqueous/ethanol solution. Meanwhile they can also be coated with polyphosphazene (PZS) in organic solution, resulting in a unique nanocable with well-defined core shell structures. Besides, taking Ag NW/Fe3O4@SiO2 as an example, a hollow magnetic silica nanotube can be obtained with the use of Ag NWs as physical templates and a solution of ammonium and H2O2. These can greatly improve the application of the Ag NW/Fe3O4 NP composites. The as-synthesized above nanocomposites have high potential for applications in the fields of polymers, wastewater treatment, sensors, and biomaterials. PMID:25815705

  10. Generic Mapping Tools: Improved Version Released

    NASA Astrophysics Data System (ADS)

    Wessel, Paul; Smith, Walter H. F.; Scharroo, Remko; Luis, Joaquim; Wobbe, Florian

    2013-11-01

    Generic Mapping Tools (GMT) is an open-source software package for the analysis and display of geoscience data, helping scientists to analyze, interpolate, filter, manipulate, project, and plot time series and gridded data sets. The GMT toolbox includes about 80 core and 40 supplemental program modules sharing a common set of command options, file structures, and documentation. Its power to process data and produce publication-quality graphic presentations has made it vital to a large scientific community that now includes more than 25,000 individual users. GMT's website (http://gmt.soest.hawaii.edu/) exceeds 20,000 visits per month, and server logs show roughly 2000 monthly downloads.

  11. Global scale observations of scattered energy near the inner-core boundary: Seismic constraints on the base of the outer-core

    NASA Astrophysics Data System (ADS)

    Adam, J. M.-C.; Romanowicz, B.

    2015-08-01

    We have collected a global dataset of several thousands of high quality records of PKPdf, PKPbc, PKPbc-diff and PKPab phase arrivals in the distance range [149-178°]. Within this collection, we have identified an energy packet that arrives 5-20 s after the PKPbc (or PKPbc-diff) and represents a phase that is not predicted by 1D reference seismic models. We use array analysis techniques to enhance the signal of these scattered phases and show that they originate along the great-circle path in a consistent range of arrival times and narrow range of ray parameters. We therefore refer to this scattered energy the "M" phase. Using the cross-correlation technique to detect and measure the scattered energy arrival times, we compiled a dataset of 1116 records of this M phase. There are no obvious variations with source or station location, nor with the depth of the source. After exploration of possible location for this M phase, we show that its origin is most likely in the vicinity of the inner-core boundary. A tentative model is found that predicts an M-like phase, and produces good fits to its travel times as well as those of the main core phases. In this model, the P velocity profile with depth exhibits an increased gradient from about 400 km to 50 km above the ICB (i.e. slightly faster velocities than in AK135 or PREM), and a ∼ 50 km thick lower velocity layer right above the ICB.

  12. A refined TALDICE-1a age scale from 55 to 112 ka before present for the Talos Dome ice core based on high-resolution methane measurements

    NASA Astrophysics Data System (ADS)

    Schüpbach, S.; Federer, U.; Bigler, M.; Fischer, H.; Stocker, T. F.

    2011-04-01

    A precise synchronization of different climate records is indispensable for a correct dynamical interpretation of paleoclimatic data. A chronology for the TALDICE ice core from the Ross Sea sector of East Antarctica has recently been presented based on methane synchronization with Greenland and the EDC ice cores and δ18Oice synchronization with EDC in the bottom part (TALDICE-1). By the use of new high-resolution methane data, obtained with a continuous flow analysis technique, we present a refined age scale for the age interval from 55-112 ka before present where TALDICE is synchronized with EDC. New and more precise tie points reduce the uncertainties of the age scale from up to 2000 yr in TALDICE-1 to below 1000 yr over most of the refined interval. Thus, discussions of climate dynamics at sub-millennial time scales are now possible back to 110 ka, in particular during the inception of the last ice age. Calcium data of EDC and TALDICE are compared to show the impact of the refinement to the synchronization of the two ice cores not only for the gas but also for the ice age scale.

  13. A refined TALDICE-1a age scale from 55 to 112 ka before present for the Talos Dome ice core based on high-resolution methane measurements

    NASA Astrophysics Data System (ADS)

    Schüpbach, S.; Federer, U.; Bigler, M.; Fischer, H.; Stocker, T. F.

    2011-09-01

    A precise synchronization of different climate records is indispensable for a correct dynamical interpretation of paleoclimatic data. A chronology for the TALDICE ice core from the Ross Sea sector of East Antarctica has recently been presented based on methane synchronization with Greenland and the EDC ice cores and δ18Oice synchronization with EDC in the bottom part (TALDICE-1). Using new high-resolution methane data obtained with a continuous flow analysis technique, we present a refined age scale for the age interval from 55-112 thousand years (ka) before present, where TALDICE is synchronized with EDC. New and more precise tie points reduce the uncertainties of the age scale from up to 1900 yr in TALDICE-1 to below 1100 yr over most of the refined interval and shift the Talos Dome dating to significantly younger ages during the onset of Marine Isotope Stage 3. Thus, discussions of climate dynamics at sub-millennial time scales are now possible back to 110 ka, in particular during the inception of the last ice age. Calcium data of EDC and TALDICE are compared to show the impact of the refinement to the synchronization of the two ice cores not only for the gas but also for the ice age scale.

  14. Modulation of mantle plumes and heat flow at the core mantle boundary by plate-scale flow: results from laboratory experiments

    NASA Astrophysics Data System (ADS)

    Gonnermann, Helge M.; Jellinek, A. Mark; Richards, Mark A.; Manga, Michael

    2004-09-01

    We report results from analog laboratory experiments, in which a large-scale flow is imposed upon natural convection from a hot boundary layer at the base of a large tank of corn syrup. The experiments show that the subdivision of the convective flow into four regions provides a reasonable conceptual framework for interpreting the effects of large-scale flow on plumes. Region I includes the area of the hot thermal boundary layer (TBL) that is thinned by the large-scale flow, thereby suppressing plumes. Region II encompasses the critically unstable boundary layer where plumes form. Region III is the area above the boundary layer that is devoid of plumes. Region IV comprises the area of hot upwelling and plume conduits. Quantitative analysis of our experiments results in a scaling law for heat flux from the hot boundary and for the spatial extent of plume suppression. When applied to the Earth's core-mantle boundary (CMB), our results suggest that large-scale mantle flow, due to sinking lithospheric plates, can locally thin the TBL and suppress plume formation over large fractions of the CMB. Approximately 30% of heat flow from the core may be due to increased heat flux from plate-scale flow. Furthermore, CMB heat flux is non-uniformly distributed along the CMB, with large areas where heat flux is increased on average by a factor of 2. As a consequence, the convective flow pattern in the outer core may be affected by CMB heat-flux heterogeneity and sensitive to changes in plate-scale mantle flow. Because of plume suppression and 'focusing' of hot mantle from the CMB into zones of upwelling flow, plume conduits (hotspots) are expected to be spatially associated with lower-mantle regions of low seismic velocities, inferred as hot upwelling mantle flow.

  15. A generic multibody simulation

    NASA Technical Reports Server (NTRS)

    Hopping, K. A.; Kohn, W.

    1986-01-01

    Described is a dynamic simulation package which can be configured for orbital test scenarios involving multiple bodies. The rotational and translational state integration methods are selectable for each individual body and may be changed during a run if necessary. Characteristics of the bodies are determined by assigning components consisting of mass properties, forces, and moments, which are the outputs of user-defined environmental models. Generic model implementation is facilitated by a transformation processor which performs coordinate frame inversions. Transformations are defined in the initialization file as part of the simulation configuration. The simulation package includes an initialization processor, which consists of a command line preprocessor, a general purpose grammar, and a syntax scanner. These permit specifications of the bodies, their interrelationships, and their initial states in a format that is not dependent on a particular test scenario.

  16. Generic names in Magnaporthales.

    PubMed

    Zhang, Ning; Luo, Jing; Rossman, Amy Y; Aoki, Takayuki; Chuma, Izumi; Crous, Pedro W; Dean, Ralph; de Vries, Ronald P; Donofrio, Nicole; Hyde, Kevin D; Lebrun, Marc-Henri; Talbot, Nicholas J; Tharreau, Didier; Tosa, Yukio; Valent, Barbara; Wang, Zonghua; Xu, Jin-Rong

    2016-06-01

    The order Magnaporthales comprises about 200 species and includes the economically and scientifically important rice blast fungus and the take-all pathogen of cereals, as well as saprotrophs and endophytes. Recent advances in phylogenetic analyses of these fungi resulted in taxonomic revisions. In this paper we list the 28 currently accepted genera in Magnaporthales with their type species and available gene and genome resources. The polyphyletic Magnaporthe 1972 is proposed for suppression, and Pyricularia 1880 and Nakataea 1939 are recommended for protection as the generic names for the rice blast fungus and the rice stem rot fungus, respectively. The rationale for the recommended names is also provided. These recommendations are made by the Pyricularia/Magnaporthe Working Group established under the auspices of the International Commission on the Taxonomy of Fungi (ICTF). PMID:27433445

  17. Generic concepts in Nectriaceae

    PubMed Central

    Lombard, L.; van der Merwe, N.A.; Groenewald, J.Z.; Crous, P.W.

    2015-01-01

    The ascomycete family Nectriaceae (Hypocreales) includes numerous important plant and human pathogens, as well as several species used extensively in industrial and commercial applications as biodegraders and biocontrol agents. Members of the family are unified by phenotypic characters such as uniloculate ascomata that are yellow, orange-red to purple, and with phialidic asexual morphs. The generic concepts in Nectriaceae are poorly defined, since DNA sequence data have not been available for many of these genera. To address this issue we performed a multi-gene phylogenetic analysis using partial sequences for the 28S large subunit (LSU) nrDNA, the internal transcribed spacer region and intervening 5.8S nrRNA gene (ITS), the large subunit of the ATP citrate lyase (acl1), the RNA polymerase II largest subunit (rpb1), RNA polymerase II second largest subunit (rpb2), α-actin (act), β-tubulin (tub2), calmodulin (cmdA), histone H3 (his3), and translation elongation factor 1-alpha (tef1) gene regions for available type and authentic strains representing known genera in Nectriaceae, including several genera for which no sequence data were previously available. Supported by morphological observations, the data resolved 47 genera in the Nectriaceae. We re-evaluated the status of several genera, which resulted in the introduction of six new genera to accommodate species that were initially classified based solely on morphological characters. Several generic names are proposed for synonymy based on the abolishment of dual nomenclature. Additionally, a new family is introduced for two genera that were previously accommodated in the Nectriaceae. PMID:26955195

  18. Low-cost and gram-scale synthesis of water-soluble Cu-In-S/ZnS core/shell quantum dots in an electric pressure cooker

    NASA Astrophysics Data System (ADS)

    Chen, Yanyan; Li, Shenjie; Huang, Lijian; Pan, Daocheng

    2014-01-01

    We report an electric pressure cooker for large-scale synthesis of water-soluble Cu-In-S/ZnS core/shell quantum dots. Low-cost thioglycolic acid and sodium citrate were used as the dual stabilizers. ~3 grams of quantum dots with a tunable emission from 545 to 610 nm and quantum yield up to 40% were obtained in a batch.We report an electric pressure cooker for large-scale synthesis of water-soluble Cu-In-S/ZnS core/shell quantum dots. Low-cost thioglycolic acid and sodium citrate were used as the dual stabilizers. ~3 grams of quantum dots with a tunable emission from 545 to 610 nm and quantum yield up to 40% were obtained in a batch. Electronic supplementary information (ESI) available: Experimental details, PL decay curves, PL lifetimes, EDS spectra, chemical composition, cost analysis. See DOI: 10.1039/c3nr05014a

  19. Generic astronomy mission planning and scheduling: The AXAF solution

    NASA Technical Reports Server (NTRS)

    Guffin, O. T.

    1994-01-01

    During SpaceOps 92 the idea of generic mission planning concepts for space astronomy missions, that could be applied to future missions in order to simplify software development, was introduced. It was proposed that mission planning systems could be decomposed into functional elements that could be standardized and then organized into optimal functional flows for each individual mission. In addition, it was further suggested that these flows themselves could be reduced to a small set of possibilities by describing them in terms of generic mission type, such as manned, unmanned, high orbit, low orbit, etc. The Advanced X-ray Astrophysics Facility (AXAF), planned for launch in the latter part of 1998, represents the first application of this idea on an unmanned mission. This paper examines the AXAF Mission Planning and Scheduling concept in light of the generic system theory. Each functional element is evaluated according to AXAF characteristics and requirements and then compared to its generic counterpart. Functional flow considerations are then derived from the overall AXAF mission planning concept to determine the viability and sensitivity of the generic flow to actual requirements. The results of this analysis are then used to update the generic system concept and to define the level of commonality and core system components that are practical to achieve across multiple missions.

  20. Generic mission planning and scheduling: The AXAF solution

    NASA Technical Reports Server (NTRS)

    Guffin, O. T.; Newhouse, M.

    1994-01-01

    During SpaceOps 92 the idea of generic mission planning concepts for space astronomy missions, that could be applied to future missions in order to simplify software development, was introduced. It was proposed that mission planning systems could be decomposed into functional elements that could be standardized and then organized into optimal functional flows for each individual mission. In addition, it was further suggested that these flows themselves could be reduced to a small set of possibilities by describing them in terms of generic mission type, such as manned, unmanned, high orbit, low orbit, etc. The Advanced X-ray Astrophysics Facility (AXAF), planned for launch in the latter part of '98, represents the first application of this idea on an unmanned mission. This paper examines the AXAF Mission Planning and Scheduling concept in light of the generic system theory. Each functional element is evaluated according to AXAF characteristics and requirements and then compared to its generic counterpart. Functional flow considerations are then derived from the overall AXAF mission planning concept to determine the viability and sensitivity of the generic flow to actual requirements. The results of this analysis are then used to update the generic system concept and to define the level of commonality and core system components that are practical to achieve across multiple missions.

  1. Generic Optimization Program

    1998-07-01

    GenOpt is a generic optimization program for nonlinear, constrained optimization. For evaluating the objective function, any simulation program that communicates over text files can be coupled to GenOpt without code modification. No analytic properties of the objective function are used by GenOpt. ptimization algorithms and numerical methods can be implemented in a library and shared among users. Gencpt offers an interlace between the optimization algorithm and its kernel to make the implementation of new algorithmsmore » fast and easy. Different algorithms of constrained and unconstrained minimization can be added to a library. Algorithms for approximation derivatives and performing line-search will be implemented. The objective function is evaluated as a black-box function by an external simulation program. The kernel of GenOpt deals with the data I/O, result sotrage and report, interlace to the external simulation program, and error handling. An abstract optimization class offers methods to interface the GenOpt kernel and the optimization algorithm library.« less

  2. New generic indexing technology

    NASA Technical Reports Server (NTRS)

    Freeston, Michael

    1996-01-01

    There has been no fundamental change in the dynamic indexing methods supporting database systems since the invention of the B-tree twenty-five years ago. And yet the whole classical approach to dynamic database indexing has long since become inappropriate and increasingly inadequate. We are moving rapidly from the conventional one-dimensional world of fixed-structure text and numbers to a multi-dimensional world of variable structures, objects and images, in space and time. But, even before leaving the confines of conventional database indexing, the situation is highly unsatisfactory. In fact, our research has led us to question the basic assumptions of conventional database indexing. We have spent the past ten years studying the properties of multi-dimensional indexing methods, and in this paper we draw the strands of a number of developments together - some quite old, some very new, to show how we now have the basis for a new generic indexing technology for the next generation of database systems.

  3. APEX/SABOCA observations of small-scale structure of infrared-dark clouds . I. Early evolutionary stages of star-forming cores

    NASA Astrophysics Data System (ADS)

    Ragan, Sarah E.; Henning, Thomas; Beuther, Henrik

    2013-11-01

    Infrared-dark clouds (IRDCs) harbor the early phases of cluster and high-mass star formation and are comprised of cold (~20 K), dense (n > 104 cm-3) gas. The spectral energy distribution (SED) of IRDCs is dominated by the far-infrared and millimeter wavelength regime, and our initial Herschel study examined IRDCs at the peak of the SED with high angular resolution. Here we present a follow-up study using the SABOCA instrument on APEX which delivers 7.8″ angular resolution at 350 μm, matching the resolution we achieved with Herschel/PACS, and allowing us to characterize substructure on ~0.1 pc scales. Our sample of 11 nearby IRDCs are a mix of filamentary and clumpy morphologies, and the filamentary clouds show significant hierarchical structure, while the clumpy IRDCs exhibit little hierarchical structure. All IRDCs, regardless of morphology, have about 14% of their total mass in small scale core-like structures which roughly follow a trend of constant volume density over all size scales. Out of the 89 protostellar cores we identified in this sample with Herschel, we recover 40 of the brightest and re-fit their SEDs and find their properties agree fairly well with our previous estimates (⟨ T ⟩ ~ 19 K). We detect a new population of "cold cores" which have no 70 μm counterpart, but are 100 and 160 μm-bright, with colder temperatures (⟨ T ⟩ ~ 16 K). This latter population, along with SABOCA-only detections, are predominantly low-mass objects, but their evolutionary diagnostics are consistent with the earliest starless or prestellar phase of cores in IRDCs. Based on observations carried out with the Atacama Pathfinder Experiment (APEX). APEX is a collaboration between Max Planck Institut für Radioastronomie (MPIfR), Onsala Space Observatory (OSO), and the European Southern Observatory (ESO).Appendices are available in electronic form at http://www.aanda.org

  4. Power-law scaling of spatially correlated porosity and log(permeability) sequences from north-central North Sea Brae oilfield well core

    NASA Astrophysics Data System (ADS)

    Leary, P. C.; Al-Kindy, F.

    2002-03-01

    The spatial cross-correlation and power spectra of porosity and log(permeability) sequences are analysed for a total of 750 m of reservoir rock drill-core from four vertical wells in the Brae Formation, an important coarse-grained clastic North Sea hydrocarbon reservoir rock. The well core sequences are 80+/-4 per cent cross-correlated at zero lag and have power-law-scaling spatial power spectra S (k )~1/k β , β ~ 1+/-0.4, for spatial frequencies 5km-1 scaling of log(permeability) spatial fluctuation spectra fit into a broad physical context of (1) the 1/k spectral scaling observed in several hundred well logs of sedimentary and crystalline rock recorded world-wide; (2) the 1/f spectral scaling of temporal sequences in a wide range of physical systems; and (3) analogy with power-law-scaling spatial fluctuation spectra in a wide range of critical-state thermodynamic systems. In this physical context, the spatial fluctuations of log(permeability) of clastic reservoir rock are interpreted as due to long-range correlated random fracture-permeability networks in a fluid-saturated granular medium where the range ξ of spatial correlation is effectively infinite. Fracture-permeability spatial fluctuations with long-range correlations and 1/k -scaling spectra have practical implications for geofluid reservoir management. Inadequate models of reservoir flow structure are widely attributed to uncertainty in fault and fracture location and connectivity. As a general phenomenon, spatial configurations of large-amplitude, long-range spatially correlated random fluctuations are unpredictable from the statistics of small-scale samples. The observed 1/k spectral scaling of porosity and log(permeability) distributions thus implies that large-scale, large-amplitude fracture-related flow heterogeneity (1) can determine the drainage pattern of crustal reservoirs but (2

  5. Triolein embedded cellulose acetate membrane as a tool to evaluate sequestration of PAHs in lake sediment core at large temporal scale.

    PubMed

    Tao, Yuqiang; Xue, Bin; Yao, Shuchun; Deng, Jiancai; Gui, Zhifan

    2012-04-01

    Although numerous studies have addressed sequestration of hydrophobic organic compounds (HOCs) in laboratory, little attention has been paid to its evaluation method in field at large temporal scale. A biomimetic tool, triolein embedded cellulose acetate membrane (TECAM), was therefore tested to evaluate sequestration of six PAHs with various hydrophobicity in a well-dated sediment core sampled from Nanyi Lake, China. Properties of sediment organic matter (OM) varying with aging time dominated the sequestration of PAHs in the sediment core. TECAM-sediment accumulation factors (MSAFs) of the PAHs declined with aging time, and significantly correlated with the corresponding biota-sediment accumulation factors (BSAFs) for gastropod (Bellamya aeruginosa) simultaneously incubated in the same sediment slices. Sequestration rates of the PAHs in the sediment core evaluated by TECAM were much lower than those obtained from laboratory study. The relationship between relative availability for TECAM (MSAF(t)/MSAF(0)) and aging time followed the first order exponential decay model. MSAF(t)/MSAF(0) was well-related to the minor changes of the properties of OM varying with aging time. Compared with chemical extraction, sequestration reflected by TECAM was much closer to that by B. aeruginosa. In contrast to B. aeruginosa, TECAM could avoid metabolism and the influences from feeding and other behaviors of organisms, and it is much easier to deploy and ready in laboratory. Hence TECAM provides an effective and convenient way to study sequestration of PAHs and probably other HOCs in field at large temporal scale.

  6. Developing Generic Software for Spacecraft Avionics

    NASA Technical Reports Server (NTRS)

    Smith, Joseph

    2003-01-01

    A proposed approach to the development of software for spacecraft avionics is based partly on a concept of generic software that could be tailored to satisfy requirements for specific missions. The proposed approach would stand in contrast to the conventional approach of first defining avionics requirements for a specific mission, then developing software specific to those requirements. The proposed approach might also be adaptable to programming computers that control and monitor other complex equipment systems that range in scale from automobiles to factories. The concept of a spacecraft avionics functional model (SAFM) is a major element of the proposed approach. An SAFM would be, essentially, a systematic and hierarchical description of the functionality required of the avionics software (and hardware) for a given mission. Although the initial input information used to start the construction of an SAFM would typically amount to a high-level description, the SAFM would thereafter be decomposed to a low level. The resulting low-level version of the model would be used to develop a set of generic requirements that could be expected to include a large fraction of all requirements for a large fraction of all missions. The generic requirements would be used to develop software modules that could be included in, or excluded from, the final flight software to satisfy the requirements of a specific mission.

  7. Generic Substitution Issues: Brand-generic Substitution, Generic-generic Substitution, and Generic Substitution of Narrow Therapeutic Index (NTI)/Critical Dose Drugs

    PubMed Central

    PAVELIU, Marian Sorin; BENGEA, Simona; PAVELIU, Fraga Silvia

    2011-01-01

    ABSTRACT Doctors accuse individual variability or lack of quality of generic drugs for adverse reactions or lack of efficacy. The variability of effect of generic substitution, although accepted by clinicians as possible, is little discussed or even understood by them. The situation is really serious in the case of generic substitution of drugs with narrow therapeutic index (NTI) or critical dose. In this paper we review the basic notions of variability and effectiveness of generic medication and change of attitude that would improve the use of these drugs. PMID:21977191

  8. Generic interpreters and microprocessor verification

    NASA Technical Reports Server (NTRS)

    Windley, Phillip J.

    1990-01-01

    The following topics are covered in viewgraph form: (1) generic interpreters; (2) Viper microprocessors; (3) microprocessor verification; (4) determining correctness; (5) hierarchical decomposition; (6) interpreter theory; (7) AVM-1; (8) phase-level specification; and future work.

  9. Hanford Generic Interim Safety Basis

    SciTech Connect

    Lavender, J.C.

    1994-09-09

    The purpose of this document is to identify WHC programs and requirements that are an integral part of the authorization basis for nuclear facilities that are generic to all WHC-managed facilities. The purpose of these programs is to implement the DOE Orders, as WHC becomes contractually obligated to implement them. The Hanford Generic ISB focuses on the institutional controls and safety requirements identified in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  10. The Generic Data Capture Facility

    NASA Technical Reports Server (NTRS)

    Connell, Edward B.; Barnes, William P.; Stallings, William H.

    1987-01-01

    The Generic Data Capture Facility, which can provide data capture support for a variety of different types of spacecraft while enabling operations costs to be carefully controlled, is discussed. The data capture functions, data protection, isolation of users from data acquisition problems, data reconstruction, and quality and accounting are addressed. The TDM and packet data formats utilized by the system are described, and the development of generic facilities is considered.

  11. The Generic Data Capture Facility

    NASA Astrophysics Data System (ADS)

    Connell, Edward B.; Barnes, William P.; Stallings, William H.

    The Generic Data Capture Facility, which can provide data capture support for a variety of different types of spacecraft while enabling operations costs to be carefully controlled, is discussed. The data capture functions, data protection, isolation of users from data acquisition problems, data reconstruction, and quality and accounting are addressed. The TDM and packet data formats utilized by the system are described, and the development of generic facilities is considered.

  12. Primordial nucleosynthesis with generic particles

    NASA Technical Reports Server (NTRS)

    Walker, T. P.; Kolb, E. W.; Turner, M. S.

    1986-01-01

    A revision of the standard model for Big Bang nucleosynthesis is discussed which allows for the presence of generic particle species. The primordial production of He-4 and D + He-3 is calculated as a function of the mass, spin degrees of freedom, and spin statistics of the generic particle for masses in the range 0.01-100 times the electron mass. The particular case of the Gelmini and Roncadelli majoron model for massive neutrinos is discussed.

  13. 27 CFR 4.24 - Generic, semi-generic, and non-generic designations of geographic significance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADVERTISING OF WINE Standards of Identity for Wine § 4.24 Generic, semi-generic, and non-generic designations... a class or type of wine, shall be deemed to have become generic only if so found by the... for a class or type of wine are: Vermouth, Sake. (b)(1) A name of geographic significance, which...

  14. Generic Example Proving Criteria for All

    ERIC Educational Resources Information Center

    Yopp, David; Ely, Rob; Johnson­-Leung, Jennifer

    2015-01-01

    We review literature that discusses generic example proving and highlight ambiguities that pervade our research community's discourse about generic example arguments. We distinguish between pedagogical advice for choosing good examples that can serve as generic examples when teaching and advice for developing generic example arguments. We provide…

  15. Modulation of Core Turbulent Density Fluctuations by Large-Scale Neoclassical Tearing Mode Islands in the DIII-D Tokamak

    NASA Astrophysics Data System (ADS)

    Bardóczi, L.; Rhodes, T. L.; Carter, T. A.; Bañón Navarro, A.; Peebles, W. A.; Jenko, F.; McKee, G.

    2016-05-01

    We report the first observation of localized modulation of turbulent density fluctuations n ˜ (via beam emission spectroscopy) by neoclassical tearing modes (NTMs) in the core of the DIII-D tokamak. NTMs are important as they often lead to severe degradation of plasma confinement and disruptions in high-confinement fusion experiments. Magnetic islands associated with NTMs significantly modify the profiles and turbulence drives. In this experiment n ˜ was found to be modulated by 14% across the island. Gyrokinetic simulations suggest that n ˜ could be dominantly driven by the ion temperature gradient instability.

  16. Modulation of Core Turbulent Density Fluctuations by Large-Scale Neoclassical Tearing Mode Islands in the DIII-D Tokamak.

    PubMed

    Bardóczi, L; Rhodes, T L; Carter, T A; Bañón Navarro, A; Peebles, W A; Jenko, F; McKee, G

    2016-05-27

    We report the first observation of localized modulation of turbulent density fluctuations n[over ˜] (via beam emission spectroscopy) by neoclassical tearing modes (NTMs) in the core of the DIII-D tokamak. NTMs are important as they often lead to severe degradation of plasma confinement and disruptions in high-confinement fusion experiments. Magnetic islands associated with NTMs significantly modify the profiles and turbulence drives. In this experiment n[over ˜] was found to be modulated by 14% across the island. Gyrokinetic simulations suggest that n[over ˜] could be dominantly driven by the ion temperature gradient instability.

  17. Scales

    MedlinePlus

    Scales are a visible peeling or flaking of outer skin layers. These layers are called the stratum ... Scales may be caused by dry skin, certain inflammatory skin conditions, or infections. Eczema , ringworm , and psoriasis ...

  18. Acoustic Source Localization via Time Difference of Arrival Estimation for Distributed Sensor Networks Using Tera-Scale Optical Core Devices

    DOE PAGESBeta

    Imam, Neena; Barhen, Jacob

    2009-01-01

    For real-time acoustic source localization applications, one of the primary challenges is the considerable growth in computational complexity associated with the emergence of ever larger, active or passive, distributed sensor networks. These sensors rely heavily on battery-operated system components to achieve highly functional automation in signal and information processing. In order to keep communication requirements minimal, it is desirable to perform as much processing on the receiver platforms as possible. However, the complexity of the calculations needed to achieve accurate source localization increases dramatically with the size of sensor arrays, resulting in substantial growth of computational requirements that cannot bemore » readily met with standard hardware. One option to meet this challenge builds upon the emergence of digital optical-core devices. The objective of this work was to explore the implementation of key building block algorithms used in underwater source localization on the optical-core digital processing platform recently introduced by Lenslet Inc. This demonstration of considerably faster signal processing capability should be of substantial significance to the design and innovation of future generations of distributed sensor networks.« less

  19. TRAC code assessment using data from SCTF Core-III, a large-scale 2D/3D facility

    SciTech Connect

    Boyack, B.E.; Shire, P.R.; Harmony, S.C.; Rhee, G.

    1988-01-01

    Nine tests from the SCTF Core-III configuration have been analyzed using TRAC-PF1/MOD1. The objectives of these assessment activities were to obtain a better understanding of the phenomena occurring during the refill and reflood phases of a large-break loss-of-coolant accident, to determine the accuracy to which key parameters are calculated, and to identify deficiencies in key code correlations and models that provide closure for the differential equations defining thermal-hydraulic phenomena in pressurized water reactors. Overall, the agreement between calculated and measured values of peak cladding temperature is reasonable. In addition, TRAC adequately predicts many of the trends observed in both the integral effect and separate effect tests conducted in SCTF Core-III. The importance of assessment activities that consider potential contributors to discrepancies between the measured and calculated results arising from three sources are described as those related to (1) knowledge about the facility configuration and operation, (2) facility modeling for code input, and (3) deficiencies in code correlations and models. An example is provided. 8 refs., 7 figs., 2 tabs.

  20. Development of TDLAS sensor for diagnostics of CO, H2O and soot concentrations in reactor core of pilot-scale gasifier

    NASA Astrophysics Data System (ADS)

    Sepman, A.; Ögren, Y.; Gullberg, M.; Wiinikka, H.

    2016-02-01

    This paper reports on the development of the tunable diode laser absorption spectroscopy sensor near 4350 cm-1 (2298 nm) for measurements of CO and H2O mole fractions and soot volume fraction under gasification conditions. Due to careful selection of the molecular transitions [CO ( υ″ = 0 → υ' = 2) R34-R36 and H2O at 4349.337 cm-1], a very weak (negligible) sensitivity of the measured species mole fractions to the temperature distribution inside the high-temperature zone (1000 K < T < 1900 K) of the gasification process is achieved. The selected transitions are covered by the tuning range of single diode laser. The CO and H2O concentrations measured in flat flames generally agree better than 10 % with the results of 1-D flame simulations. Calibration-free absorption measurements of studied species in the reactor core of atmospheric pilot-scale entrained-flow gasifier operated at 0.1 MW power are reported. Soot concentration is determined from the measured broadband transmittance. The estimated uncertainties in the reactor core CO and H2O measurements are 15 and 20 %, respectively. The reactor core average path CO mole fractions are in quantitative agreement with the µGC CO concentrations sampled at the gasifier output.

  1. Multi-scale petrophysical and geomechanical characterization of full core from the Groningen Field to understand mechanical stratigraphy and compaction behavior

    NASA Astrophysics Data System (ADS)

    van Eijs, Rob; Hol, Sander; Marcelis, Fons; Ishmukhametova, Gulfiia; van der Linden, Arjan; Zuiderwijk, Pedro; Makurat, Axel

    2016-04-01

    The Groningen gas field in The Netherlands is one of the largest onshore gas reserves known. Advancing production from the field has resulted in field-scale deformation with surface subsidence and accompanied local seismicity. Part of the deformation is associated with compaction of the Permian reservoir. While depletion-induced reservoir compaction is expected to be controlled locally by grain-scale physical mechanisms such as sub-critical cracking or particle re-arrangement and intergranular pressure solution creep, understanding of the intra-reservoir variability of these mechanisms is still limited, though crucial for predicting the coupling between production, rock deformation, and surface effects. To aid an improved understanding of fundamental processes and scaling effects, approximately 200 meters of core over the reservoir section was taken from a well in the Groningen Field, drilled in July 2015 close to the village of Zeerijp. Using this material, we have performed detailed laboratory investigations and will continue to do so in significant numbers, to compare the results obtained with well- and field-scale observations. In this contribution, we present several exemplary mechanical data sets for the reservoir and caprock, and compare these data with well-scale petrophysical and mechanical information, notably sonic, scratch and visual geological details with the aim to arrive at a multi-scale description of petrophysical and geomechanical rock properties. Our first comparison reveals a strong contrast in compressibility and strength between the reservoir and caprock, as well as a contribution of inelastic strain to the total strain response of the tested rock samples. We will discuss the observed mechanical stratigraphy in considering regional and field scale deformation patterns.

  2. Characterization of reactive flow-induced evolution of carbonate rocks using digital core analysis- part 1: Assessment of pore-scale mineral dissolution and deposition.

    PubMed

    Qajar, Jafar; Arns, Christoph H

    2016-09-01

    The application of X-ray micro-computed tomography (μ-CT) for quantitatively characterizing reactive-flow induced pore structure evolution including local particle detachment, displacement and deposition in carbonate rocks is investigated. In the studies conducted in this field of research, the experimental procedure has involved alternating steps of imaging and ex-situ core sample alteration. Practically, it is impossible to return the sample, with micron precision, to the same position and orientation. Furthermore, successive images of a sample in pre- and post-alteration states are usually taken at different conditions such as different scales, resolutions and signal-to-noise ratios. These conditions accompanying with subresolution features in the images make voxel-by-voxel comparisons of successive images problematic. In this paper, we first address the respective challenges in voxel-wise interpretation of successive images of carbonate rocks subject to reactive flow. Reactive coreflood in two carbonate cores with different rock types are considered. For the first rock, we used the experimental and imaging results published by Qajar et al. (2013) which showed a quasi-uniform dissolution regime. A similar reactive core flood was conducted in the second rock which resulted in wormhole-like dissolution regime. We particularly examine the major image processing operations such as transformation of images to the same grey-scale, noise filtering and segmentation thresholding and propose quantitative methods to evaluate the effectiveness of these operations in voxel-wise analysis of successive images of a sample. In the second part, we generalize the methodology based on the three-phase segmentation of normalized images, microporosity assignment and 2D histogram of image intensities to estimate grey-scale changes of individual image voxels for a general case where the greyscale images are segmented into arbitrary number of phases. The results show that local (voxel

  3. Characterization of reactive flow-induced evolution of carbonate rocks using digital core analysis- part 1: Assessment of pore-scale mineral dissolution and deposition

    NASA Astrophysics Data System (ADS)

    Qajar, Jafar; Arns, Christoph H.

    2016-09-01

    The application of X-ray micro-computed tomography (μ-CT) for quantitatively characterizing reactive-flow induced pore structure evolution including local particle detachment, displacement and deposition in carbonate rocks is investigated. In the studies conducted in this field of research, the experimental procedure has involved alternating steps of imaging and ex-situ core sample alteration. Practically, it is impossible to return the sample, with micron precision, to the same position and orientation. Furthermore, successive images of a sample in pre- and post-alteration states are usually taken at different conditions such as different scales, resolutions and signal-to-noise ratios. These conditions accompanying with subresolution features in the images make voxel-by-voxel comparisons of successive images problematic. In this paper, we first address the respective challenges in voxel-wise interpretation of successive images of carbonate rocks subject to reactive flow. Reactive coreflood in two carbonate cores with different rock types are considered. For the first rock, we used the experimental and imaging results published by Qajar et al. (2013) which showed a quasi-uniform dissolution regime. A similar reactive core flood was conducted in the second rock which resulted in wormhole-like dissolution regime. We particularly examine the major image processing operations such as transformation of images to the same grey-scale, noise filtering and segmentation thresholding and propose quantitative methods to evaluate the effectiveness of these operations in voxel-wise analysis of successive images of a sample. In the second part, we generalize the methodology based on the three-phase segmentation of normalized images, microporosity assignment and 2D histogram of image intensities to estimate grey-scale changes of individual image voxels for a general case where the greyscale images are segmented into arbitrary number of phases. The results show that local (voxel

  4. Characterization of reactive flow-induced evolution of carbonate rocks using digital core analysis- part 1: Assessment of pore-scale mineral dissolution and deposition.

    PubMed

    Qajar, Jafar; Arns, Christoph H

    2016-09-01

    The application of X-ray micro-computed tomography (μ-CT) for quantitatively characterizing reactive-flow induced pore structure evolution including local particle detachment, displacement and deposition in carbonate rocks is investigated. In the studies conducted in this field of research, the experimental procedure has involved alternating steps of imaging and ex-situ core sample alteration. Practically, it is impossible to return the sample, with micron precision, to the same position and orientation. Furthermore, successive images of a sample in pre- and post-alteration states are usually taken at different conditions such as different scales, resolutions and signal-to-noise ratios. These conditions accompanying with subresolution features in the images make voxel-by-voxel comparisons of successive images problematic. In this paper, we first address the respective challenges in voxel-wise interpretation of successive images of carbonate rocks subject to reactive flow. Reactive coreflood in two carbonate cores with different rock types are considered. For the first rock, we used the experimental and imaging results published by Qajar et al. (2013) which showed a quasi-uniform dissolution regime. A similar reactive core flood was conducted in the second rock which resulted in wormhole-like dissolution regime. We particularly examine the major image processing operations such as transformation of images to the same grey-scale, noise filtering and segmentation thresholding and propose quantitative methods to evaluate the effectiveness of these operations in voxel-wise analysis of successive images of a sample. In the second part, we generalize the methodology based on the three-phase segmentation of normalized images, microporosity assignment and 2D histogram of image intensities to estimate grey-scale changes of individual image voxels for a general case where the greyscale images are segmented into arbitrary number of phases. The results show that local (voxel

  5. CopperCore Service Integration

    ERIC Educational Resources Information Center

    Vogten, Hubert; Martens, Harrie; Nadolski, Rob; Tattersall, Colin; van Rosmalen, Peter; Koper, Rob

    2007-01-01

    In an e-learning environment there is a need to integrate various e-learning services like assessment services, collaboration services, learning design services and communication services. In this article we present the design and implementation of a generic integrative service framework, called CopperCore Service Integration (CCSI). We will…

  6. Large-scale volcaniclastic turbidites from subaerial caldera-forming eruptions at Dominica: insights from IODP site U1398 cores

    NASA Astrophysics Data System (ADS)

    Maeno, F.; Ishizuka, O.; Kataoka, K.; Le Friant, A.; Boudon, G.; Villemant, B.

    2014-12-01

    Volcaniclastic turbidity currents can be caused by subaerial explosive eruptions. However, their flow and emplacement processes in oceanic environment are still ambiguous. Core data obtained by deep-ocean drilling give constraints on the origin of such turbidity currents and resultant deposits. In this presentation, stratigraphy and grain data of volcaniclastic deposits from IODP site U1398 cores are shown and the origin of the deposit is discussed. The site is located 120 km southwest of Dominica Island. The uppermost unit that we study extends 0-40 mbsf. The main part is composed of a series of thick massive volcaniclastic turbidites, and is divided into several subunits. Each subunit has a few to 10 m thick and is separated by thin layers of fine materials or hemipelagic mud. Most of the layers are massive, composed of sorted, medium to coarse sand, and poor in fines. Some are normally graded. The upper turbidite is thick and massive, and contains abundant pumice clasts. They tend to concentrate in middle or upper part of the layer. Components of matrix are represented by pumice, massive lava, crystals (pl, opx, cpx, qz, hbl, titanomagnetite), and sparse carbonates. Generally, in normally graded layers, upper finer part is rich in pumice and bioclasts, and lower part is richer in crystals. In some layers, crystal concentration in matrix vary in proportion up to 80 wt.%, and its variation is correlated with magnetic susceptibility data. Grain size and component characteristics and their variations are thought to reflect emplacement process of volcaniclastic turbidity currents. Importantly, the grain characteristics are almost identical to the previous description for subaerial deposits or piston core data of the Roseau Tuff (~30 ka B.P.) that originated from the largest eruption in the Lesser Antilles in the last 200,000 years. The eruption formed caldera(s) on land in Dominica, and the most of the materials were deposited beneath the sea. Also it has been

  7. Retailing policies for generic medicines.

    PubMed

    Narciso, Susana

    2005-06-01

    As there is general disagreement about the way generic medicines should be commercialized, two retailing policies are analyzed, taking into account their effects on the welfare of patients, government, pharmacies and physicians. In the first policy scenario, pharmacies are allowed to substitute generic medicines for branded ones, while in the second, substitution is forbidden. In both cases a pharmacies association is allowed to have a share in the production of generic medicines. The model predicts that under some conditions patients may prefer substitution by pharmacies but when doctors' decisions are binding, they are never "excessively bad". However, the policy choice belongs to the government, which prefers to allow for substitution more often than patients would like. PMID:15912315

  8. Generic medications for hepatitis C.

    PubMed

    Jensen, Donald M; Sebhatu, Phoebe; Reau, Nancy S

    2016-07-01

    The recent development and approval of expensive but highly effective oral agents against hepatitis C has led to restrictions and access limitations in many countries with limited healthcare budgets. Generic formulations of many of these agents are available at a fraction of the retail price in several countries because of generic licensure agreements. The discounted alternatives are only accessible in developing countries and require manufacturing and distribution regulations to ensure the quality and bioequivalence of the new drug formulations. The continued medication access limitations have driven great interest in the practice of personal drug importation of the generic formulations. This review and debate will address the medical and legal issues involved in the purchase and importation of these medicines. PMID:27306302

  9. Retailing policies for generic medicines.

    PubMed

    Narciso, Susana

    2005-06-01

    As there is general disagreement about the way generic medicines should be commercialized, two retailing policies are analyzed, taking into account their effects on the welfare of patients, government, pharmacies and physicians. In the first policy scenario, pharmacies are allowed to substitute generic medicines for branded ones, while in the second, substitution is forbidden. In both cases a pharmacies association is allowed to have a share in the production of generic medicines. The model predicts that under some conditions patients may prefer substitution by pharmacies but when doctors' decisions are binding, they are never "excessively bad". However, the policy choice belongs to the government, which prefers to allow for substitution more often than patients would like.

  10. Permeability Evolution During Reactive Flow Experiments on Cores Under CO2 Sequestration Conditions and Development of Fully Coupled Reactive Flow Simulations at the Reservoir Scale

    NASA Astrophysics Data System (ADS)

    Saar, M. O.; Kong, X. Z.; Luhmann, A. J.; Tutolo, B. M.; Seyfried, W. E., Jr.

    2015-12-01

    Physical, chemical, thermal, and mechanical processes can modify permeability and affect CO2 injectivity and reactive fluid flow during geologic CO2 sequestration. Here we report permeability evolutions observed in core-flood experiments using CO2-charged fluids under various formation conditions. Temperature-series experiments on consolidated dolomite cores show a permeability increase due to dissolution, followed by a two-step permeability decrease due to CO2 exsolution and secondary dolomite precipitation, as temperature is increased from 21 to 50°C and then to 100°C, respectively. CO2 mass balance calculations suggest that, under dynamic steady-state conditions, CO2 saturation and its relative permeability can only reach up to ~0.5 and ~0.0065, respectively. Permeability reductions of ~1/3 and mass losses of ~2% are observed both in a 52-day recycling and in two 3-day single-pass experiments with K-feldspar-rich sandstone (150°C, 200 bar). Water chemistry, SEM, and XRCT data suggest feldspar dissolution and precipitation of either boehmite (recycling) or kaolinite (single-pass) during the experiments. These observations indicate that permeability can decrease with increasing porosity due to mineral precipitation in critical pore throats. Single-pass experiments on nine dolomite cores (150°C and 150 bar with NaCl) reveal permeability enhancements and dissolution patterns at different flow rates. Permeability-porosity data indicate an increase in permeability enhancement rate per increase in porosity with reaction progress as dissolution channels lengthen along the core. These experimental observations provide the requisite data for informing up-scaled, fully-coupled reactive transport simulations of CO2 sequestration in interbedded siliclastic-carbonate sedimentary reservoirs, which we present.

  11. QUANTIFYING THE SIGNIFICANCE OF THE MAGNETIC FIELD FROM LARGE-SCALE CLOUD TO COLLAPSING CORE: SELF-SIMILARITY, MASS-TO-FLUX RATIO, AND STAR FORMATION EFFICIENCY

    SciTech Connect

    Koch, Patrick M.; Ho, Paul T. P.; Tang, Ya-Wen

    2012-03-01

    Dust polarization observational results are analyzed for the high-mass star formation region W51 from the largest parent cloud ({approx}2 pc, James Clerk Maxwell Telescope) to the large-scale envelope ({approx}0.5 pc, BIMA array) down to the collapsing core e2 ({approx}60 mpc, Submillimeter Array). Magnetic field and dust emission gradient orientations reveal a correlation which becomes increasingly more tight with higher resolution. The previously developed polarization-intensity-gradient method is applied in order to quantify the magnetic field significance. This technique provides a way to estimate the local magnetic field force compared to gravity without the need of any mass or field strength measurements, solely making use of measured angles which reflect the geometrical imprint of the various forces. All three data sets clearly show regions with distinct features in the field-to-gravity force ratio. Azimuthally averaged radial profiles of this force ratio reveal a transition from a field dominance at larger distances to a gravity dominance closer to the emission peaks. Normalizing these profiles to a characteristic core scale points toward self-similarity. Furthermore, the polarization-intensity-gradient method is linked to the mass-to-flux ratio, providing a new approach to estimate the latter one without mass and field strength inputs. A transition from a magnetically supercritical to a subcritical state as a function of distance from the emission peak is found for the e2 core. Finally, based on the measured radius-dependent field-to-gravity force ratio we derive a modified star formation efficiency with a diluted gravity force. Compared to a standard (free-fall) efficiency, the observed field is capable of reducing the efficiency down to 10% or less.

  12. Scaling To A Million Cores And Beyond: Using Light-Weight Simulation to Understand The Challenges Ahead On The Road To Exascale

    SciTech Connect

    Engelmann, Christian

    2014-01-01

    As supercomputers scale to 1,000 PFlop/s over the next decade, investigating the performance of parallel applications at scale on future architectures and the performance impact of different architecture choices for high-performance computing (HPC) hardware/software co-design is crucial. This paper summarizes recent efforts in designing and implementing a novel HPC hardware/software co-design toolkit. The presented Extreme-scale Simulator (xSim) permits running an HPC application in a controlled environment with millions of concurrent execution threads while observing its performance in a simulated extreme-scale HPC system using architectural models and virtual timing. This paper demonstrates the capabilities and usefulness of the xSim performance investigation toolkit, such as its scalability to 2^27 simulated Message Passing Interface (MPI) ranks on 960 real processor cores, the capability to evaluate the performance of different MPI collective communication algorithms, and the ability to evaluate the performance of a basic Monte Carlo application with different architectural parameters.

  13. Software synthesis using generic architectures

    NASA Technical Reports Server (NTRS)

    Bhansali, Sanjay

    1993-01-01

    A framework for synthesizing software systems based on abstracting software system designs and the design process is described. The result of such an abstraction process is a generic architecture and the process knowledge for customizing the architecture. The customization process knowledge is used to assist a designer in customizing the architecture as opposed to completely automating the design of systems. Our approach using an implemented example of a generic tracking architecture which was customized in two different domains is illustrated. How the designs produced using KASE compare to the original designs of the two systems, and current work and plans for extending KASE to other application areas are described.

  14. Toward the Cenozoic Megasplice - high-resolution XRF core scanning data and improved composite records from IODP Expedition 320: implications for fine scale paleoceanography (Invited)

    NASA Astrophysics Data System (ADS)

    Westerhold, T.; Bown, P. R.; Dunkley Jones, T.; Lyle, M. W.; Moore, T. C.; Pälike, H.; Roehl, U.; Wilkens, R. H.; Expedition 320/321 Scientists

    2010-12-01

    A critical need to study past climate change is to sufficiently constrain the ages of past climate events so that global relationships can be discerned. Integrated Ocean Drilling Program (IODP) Expedition 320 recovered high-quality pelagic Cenozoic records with over 800 dated paleomagnetic reversals and decimeter-scale cyclic sediments. These new profiles provide an outstanding framework to inter-calibrate major microfossil groups and refine magnetic polarity chrons for the late Miocene, the entire Oligocene and the late Eocene Epochs. The compilation of a Cenozoic Megasplice which integrates all available bio-, chemo-, and magnetostratigraphic data including those from key records already recovered during Ocean Drilling Program (ODP) Leg 199 is one of the major objectives of the Pacific Equatorial Age Transect (PEAT, IODP Exp. 320 & 321) and prerequisite for further reconstructing the climate history of the Equatorial Pacific in detail. Here we present extended post-cruise refinements of the shipboard composite records of IODP Exp. 320 Sites U1331, U1332, U1333, U1334 as well as ODP Leg 199 Sites 1218, 1219 and 1220. The revised composite records were used to perform a site-to-site correlation and integration of Leg 199 and Exp. 320 sites. Based on this decimeter scale correlation a high resolution integrated paleomagnetic and biostratigraphic framework for the Equatorial Pacific is established which covers the time interval from 20 to 40 Ma. This framework will be the key for further high-resolution paleoceanographic interpretations of the late Paleogene, e.g. the E/O transition. As part of our study we also present high resolution X-ray fluorescence (XRF) core scanning data acquired from more than 1200 meters of sediment cores from Exp. 320 and Leg 199 encompassing the middle Eocene to early Oligocene (magnetochrons C12n to C20n). These new, critical records enable us to improve the orbitally tuned time scale and to reconstruct variations in the carbonate

  15. A 50,000-year climatic record from the new coastal TALDICE ice core: consequences on millennial-scale variability features through the Antarctic continent

    NASA Astrophysics Data System (ADS)

    Buiron, Daphné; Stenni, Barbara; Frezzoti, Massimo; Chappellaz, Jerome; Lemieux, Benedicte; Masson-Delmotte, Valérie; Schilt, Adrian

    2010-05-01

    The TALDICE project retrieved a new ice core from a peripheral dome of East Antarctica. Talos Dome (72° 49' S, 159° 11' E; 2315 m; mean accumulation rate 80 kg m-2 yr-1; mean annual temp. -41°C) is located in the Northern Victoria Land, close to the Ross Sea. Back-trajectory analyses suggest that the site is mostly fed by air masses arriving both from the Pacific (and Ross Sea) and Indian Ocean sectors. The drilling team reached the depth of 1619.2 m in December 2007, covering more than 300,000 years of climatic records according to a preliminary age scale. Up to 50,000 years before present, the ice core dating is based on the use of a glaciological model and an inverse method, constrained by numerous and reliable age markers. They are defined from the synchronization of CH4 records of Talos Dome and Greenland ice cores, using in particular the rapid CH4 changes associated with the last termination and the D/O events. Measurements of the CH4 mixing ratio have been performed by LGGE and Bern laboratories using slightly different techniques, with a depth resolution ranging between 0.5 to 4 m. The comparison of water isotopic profiles from Talos Dome, EDC, EDML (Antarctica) and North-GRIP (Greenland) ice cores, once put on a common time scale deduced from CH4 and the optimisation from the inverse method, reveals that during the last deglaciation and the last glacial period, climatic changes at Talos Dome were essentially in phase with the Antarctic plateau, extending the bipolar seesaw sequence to this coastal site. This comparison also highlights different climatic behaviors between sites situated in the Indo/Pacific sector and in the Atlantic sector of the Southern Ocean, the latter showing more abrupt swings toward relatively warm conditions of the Antarctic Isotope Maxima. We will discuss this feature with respect to the bipolar seesaw model of Stocker (2003) and with respect to other climatic proxies.

  16. CO2 Exsolution from CO2 Saturated Water: Core-Scale Experiments and Focus on Impacts of Pressure Variations.

    PubMed

    Xu, Ruina; Li, Rong; Ma, Jin; Jiang, Peixue

    2015-12-15

    For CO2 sequestration and utilization in the shallow reservoirs, reservoir pressure changes are due to the injection rate changing, a leakage event, and brine withdrawal for reservoir pressure balance. The amounts of exsolved CO2 which are influenced by the pressure reduction and the subsequent secondary imbibition process have a significant effect on the stability and capacity of CO2 sequestration and utilization. In this study, exsolution behavior of the CO2 has been studied experimentally using a core flooding system in combination with NMR/MRI equipment. Three series of pressure variation profiles, including depletion followed by imbibitions without or with repressurization and repetitive depletion and repressurization/imbibition cycles, were designed to investigate the exsolution responses for these complex pressure variation profiles. We found that the exsolved CO2 phase preferentially occupies the larger pores and exhibits a uniform spatial distribution. The mobility of CO2 is low during the imbibition process, and the residual trapping ratio is extraordinarily high. During the cyclic pressure variation process, the first cycle has the largest contribution to the amount of exsolved CO2. The low CO2 mobility implies a certain degree of self-sealing during a possible reservoir depletion. PMID:26509211

  17. CO2 Exsolution from CO2 Saturated Water: Core-Scale Experiments and Focus on Impacts of Pressure Variations.

    PubMed

    Xu, Ruina; Li, Rong; Ma, Jin; Jiang, Peixue

    2015-12-15

    For CO2 sequestration and utilization in the shallow reservoirs, reservoir pressure changes are due to the injection rate changing, a leakage event, and brine withdrawal for reservoir pressure balance. The amounts of exsolved CO2 which are influenced by the pressure reduction and the subsequent secondary imbibition process have a significant effect on the stability and capacity of CO2 sequestration and utilization. In this study, exsolution behavior of the CO2 has been studied experimentally using a core flooding system in combination with NMR/MRI equipment. Three series of pressure variation profiles, including depletion followed by imbibitions without or with repressurization and repetitive depletion and repressurization/imbibition cycles, were designed to investigate the exsolution responses for these complex pressure variation profiles. We found that the exsolved CO2 phase preferentially occupies the larger pores and exhibits a uniform spatial distribution. The mobility of CO2 is low during the imbibition process, and the residual trapping ratio is extraordinarily high. During the cyclic pressure variation process, the first cycle has the largest contribution to the amount of exsolved CO2. The low CO2 mobility implies a certain degree of self-sealing during a possible reservoir depletion.

  18. Generic Software Architecture for Launchers

    NASA Astrophysics Data System (ADS)

    Carre, Emilien; Gast, Philippe; Hiron, Emmanuel; Leblanc, Alain; Lesens, David; Mescam, Emmanuelle; Moro, Pierre

    2015-09-01

    The definition and reuse of generic software architecture for launchers is not so usual for several reasons: the number of European launcher families is very small (Ariane 5 and Vega for these last decades); the real time constraints (reactivity and determinism needs) are very hard; low levels of versatility are required (implying often an ad hoc development of the launcher mission). In comparison, satellites are often built on a generic platform made up of reusable hardware building blocks (processors, star-trackers, gyroscopes, etc.) and reusable software building blocks (middleware, TM/TC, On Board Control Procedure, etc.). If some of these reasons are still valid (e.g. the limited number of development), the increase of the available CPU power makes today an approach based on a generic time triggered middleware (ensuring the full determinism of the system) and a centralised mission and vehicle management (offering more flexibility in the design and facilitating the long term maintenance) achievable. This paper presents an example of generic software architecture which could be envisaged for future launchers, based on the previously described principles and supported by model driven engineering and automatic code generation.

  19. Strike-slip linked core complexes: A new kinematic model of basement rock exhumation in a crustal-scale fault system

    NASA Astrophysics Data System (ADS)

    Meyer, Sven Erik; Passchier, Cees; Abu-Alam, Tamer; Stüwe, Kurt

    2014-05-01

    Metamorphic core complexes usually develop as extensional features during continental crustal thinning, such as the Basin and Range and the Aegean Terrane. The Najd fault system in Saudi Arabia is a 2000 km-long and 400 km-wide complex network of crustal-scale strike-slip shear zones in a Neoproterozoic collision zone. Locally, the anastomosing shear zones lead to exhumation of lower crustal segments and represent a new kinematic model for the development of core complexes. We report on two such structures: the Qazaz complex in Saudi Arabia and the Hafafit complex in Egypt. The 15 km-wide Qazaz complex is a triangular dome of gently dipping mylonitic foliations within the 140 km-long sinistral strike-slip Qazaz mylonite zone. The gneissic dome consists of high-grade rocks, surrounded by low-grade metasediments and metavolcanics. The main SE-trending strike-slip Qazaz shear zone splits southwards into two branches around the gneiss dome: the western branch is continuous with the shallow dipping mylonites of the dome core, without overprinting, and changes by more than 90 degrees from a NS-trending strike-slip zone to an EW-trending 40 degree south-dipping detachment that bounds the gneiss dome to the south. The eastern SE-trending sinistral strike-slip shear zone branch is slightly younger and transects the central dome fabrics. The gneiss dome appears to have formed along a jog in the strike-slip shear zone during 40 km of horizontal strike-slip motion, which caused local exhumation of lower crustal rocks by 25 km along the detachment. The eastern shear zone branch formed later during exhumation, transacted the gneiss dome and offset the two parts by another 70 km. The Hafafit core complex in Egypt is of similar shape and size to the Qazaz structure, but forms the northern termination of a sinistral strike-slip zone that is at least 100 km in length. This zone may continue into Saudi Arabia as the Ajjaj shear zone for another 100 km. The NW trending strike slip

  20. Core and Large-Scale Structure of the 2000 November 24 X-Class Flare and Coronal Mass Ejection

    NASA Technical Reports Server (NTRS)

    Wang, Haimin; Gallagher, Peter; Yurchyshyn, Vasyl; Yang, Guo; Godde, Philip R.

    2002-01-01

    In this paper, we present three important aspects of the XI .8 flare and the associated coronal mass ejection (CME) that occurred on 2000 November 24: (1) The source of the flare is clearly associated with a magnetic channel structure, as was noted in a study by Zirin & Wang , which is due to a combination of flux emergence inside the leading edge of the penumbra of the major leading sunspot and proper motion of the sunspot group. The channel structure provides evidence for twisted flux ropes that can erupt, forming the core of a CME, and may be a common property of several superactive regions that have produced multiple X-class flares in the past. (2) There are actually three flare ribbons visible. The first can be seen moving away from the flare site, while the second and third make up a stationary ribbon near the leader spot. The moving ribbons could be due to a shock associated with the erupting flux rope or due to the interaction of erupting rope and the surrounding magnetic fields. In either case, the ribbon motion does not fit the classical Kopp-Pneuman model, in which the separation of ribbons is due to magnetic reconnection at successively higher and higher coronal altitudes. (3) From the coronal dimming observed with the EUV Imaging Telescope (EIT), the CME involved a much larger region than the initial X-class flare. By comparing high-resolution full-disk Ha and EIT observations, we found that a remote dimming area is cospatial with the enhanced Ha emission. This result is consistent with the recent model of Yokoyama & Shibata that some dimming areas near footpoints may be due to chromospheric evaporation.

  1. The connection between chromatin motion on the 100 nm length scale and core histone dynamics in live XTC-2 cells and isolated nuclei.

    PubMed

    Davis, Sara K; Bardeen, Christopher J

    2004-01-01

    The diffusive motion of DNA-containing chromatin in live cells and isolated nuclei is investigated using a two-photon standing wave fluorescence photobleaching experiment with 100 nm spatial resolution. The chromatin is labeled using the minor groove binding dye Hoechst 33342. In live cells, the mean diffusion rate is 5 x 10(-4) micro m2/s, with considerable cell-to-cell variation. This diffusion is highly constrained and cannot be observed in a standard, single beam fluorescence recovery after photobleaching experiment. To determine the chemical origin of the diffusion, we study motion in isolated nuclei and vary the strength of the histone-DNA interactions by changing the ionic strength and using chemical and photocross-linking experiments. At higher NaCl concentrations, we see increased chromatin diffusion as the histone-DNA interaction is weakened due to ionic screening, whereas photocross-linking the core histones to the DNA results in a complete absence of diffusive motion. These trends are consistent with the 100 nm scale motion being correlated with the interactions of histone proteins with the DNA. If chromatin diffusion is connected to the nucleosomal dynamics on much smaller length scales, this may provide a way to assay biochemical activity in vivo based on larger scale macromolecular dynamics observed via fluorescence microscopy.

  2. The generic danger and the idiosyncratic support

    NASA Astrophysics Data System (ADS)

    Temme, Arnaud; Nijp, Jelmer; van der Meij, Marijn; Samia, Jalal; Masselink, Rens

    2016-04-01

    This contribution argues two main points. First, that generic landscapes used in some modelling studies sometimes have properties or cause simulation results that are unrealistic. Such initially flat or straight-sloped landscapes, sometimes with minor random perturbations, e.g. form the backdrop for ecological simulations of vegetation growth and competition that predict catastrophic shifts. Exploratory results for semi-arid systems suggest that the results based on these generic landscapes are end-members from a distribution of results, rather than an unbiased, typical outcome. Apparently, the desire to avoid idiosyncrasy has unintended consequences. Second, we argue and illustrate that in fact new insights often come from close inspection of idiosyncratic case studies. Our examples from landslide systems, connectivity and soil formation show how a central role for the case study - either in empirical work or to provide model targets - has advanced our understanding. Both points contribute to the conclusion that it is dangerous to forget about annoying, small-scale, idiosyncratic and, indeed, perhaps bad-ass case studies in Earth Sciences.

  3. The Impact of Century-Scale Changes in the Core Magnetic Field on External Magnetic Field Contributions

    NASA Astrophysics Data System (ADS)

    Cnossen, Ingrid

    2016-08-01

    The Earth's internal magnetic field controls to a degree the strength, geographic positioning, and structure of currents flowing in the ionosphere and magnetosphere, which produce their own (external) magnetic fields. The secular variation of the Earth's internal magnetic field can therefore lead to long-term changes in the externally produced magnetic field as well. Here we will examine this more closely. First, we obtain scaling relations to describe how the strength of magnetic perturbations associated with various different current systems in the ionosphere and magnetosphere depends on the internal magnetic field intensity. Second, we discuss how changes in the orientation of a simple dipolar magnetic field will affect the current systems. Third, we use model simulations to study how actual changes in the Earth's internal magnetic field between 1908 and 2008 have affected some of the relevant current systems. The influence of the internal magnetic field on low- to mid-latitude currents in the ionosphere is relatively well understood, while the effects on high-latitude current systems and currents in the magnetosphere still pose considerable challenges.

  4. Collective response to public health emergencies and large-scale disasters: putting hospitals at the core of community resilience.

    PubMed

    Paturas, James L; Smith, Deborah; Smith, Stewart; Albanese, Joseph

    2010-07-01

    Healthcare organisations are a critical part of a community's resilience and play a prominent role as the backbone of medical response to natural and manmade disasters. The importance of healthcare organisations, in particular hospitals, to remain operational extends beyond the necessity to sustain uninterrupted medical services for the community, in the aftermath of a large-scale disaster. Hospitals are viewed as safe havens where affected individuals go for shelter, food, water and psychosocial assistance, as well as to obtain information about missing family members or learn of impending dangers related to the incident. The ability of hospitals to respond effectively to high-consequence incidents producing a massive arrival of patients that disrupt daily operations requires surge capacity and capability. The activation of hospital emergency support functions provides an approach by which hospitals manage a short-term shortfall of hospital personnel through the reallocation of hospital employees, thereby obviating the reliance on external qualified volunteers for surge capacity and capability. Recent revisions to the Joint Commission's hospital emergency preparedness standard have impelled healthcare facilities to participate actively in community-wide planning, rather than confining planning exclusively to a single healthcare facility, in order to harmonise disaster management strategies and effectively coordinate the allocation of community resources and expertise across all local response agencies.

  5. Generic Language and Judgements about Category Membership: Can Generics Highlight Properties as Central?

    ERIC Educational Resources Information Center

    Hollander, Michelle A.; Gelman, Susan A.; Raman, Lakshmi

    2009-01-01

    Many languages distinguish generic utterances (e.g., "Tigers are ferocious") from non-generic utterances (e.g., "Those tigers are ferocious"). Two studies examined how generic language specially links properties and categories. We used a novel-word extension task to ask if 4- to 5-year-old children and adults distinguish between generic and…

  6. Scale

    ERIC Educational Resources Information Center

    Schaffhauser, Dian

    2009-01-01

    The common approach to scaling, according to Christopher Dede, a professor of learning technologies at the Harvard Graduate School of Education, is to jump in and say, "Let's go out and find more money, recruit more participants, hire more people. Let's just keep doing the same thing, bigger and bigger." That, he observes, "tends to fail, and fail…

  7. Scalable Triadic Analysis of Large-Scale Graphs: Multi-Core vs. Multi-Processor vs. Multi-Threaded Shared Memory Architectures

    SciTech Connect

    Chin, George; Marquez, Andres; Choudhury, Sutanay; Feo, John T.

    2012-09-01

    Triadic analysis encompasses a useful set of graph mining methods that is centered on the concept of a triad, which is a subgraph of three nodes and the configuration of directed edges across the nodes. Such methods are often applied in the social sciences as well as many other diverse fields. Triadic methods commonly operate on a triad census that counts the number of triads of every possible edge configuration in a graph. Like other graph algorithms, triadic census algorithms do not scale well when graphs reach tens of millions to billions of nodes. To enable the triadic analysis of large-scale graphs, we developed and optimized a triad census algorithm to efficiently execute on shared memory architectures. We will retrace the development and evolution of a parallel triad census algorithm. Over the course of several versions, we continually adapted the code’s data structures and program logic to expose more opportunities to exploit parallelism on shared memory that would translate into improved computational performance. We will recall the critical steps and modifications that occurred during code development and optimization. Furthermore, we will compare the performances of triad census algorithm versions on three specific systems: Cray XMT, HP Superdome, and AMD multi-core NUMA machine. These three systems have shared memory architectures but with markedly different hardware capabilities to manage parallelism.

  8. Generic Language in Parent-Child Conversations.

    PubMed

    Gelman, Susan A; Goetz, Peggy J; Sarnecka, Barbara W; Flukes, Jonathan

    2008-01-01

    Generic knowledge concerns kinds of things (e.g., birds fly; a chair is for sitting; gold is a metal). Past research demonstrated that children spontaneously develop generic knowledge by preschool age. The present study examines when and how children learn to use the multiple devices provided by their language to express generic knowledge. We hypothesize that children assume, in the absence of specifying information or context, that nouns refer to generic kinds, as a default. Thus, we predict that (a) Children should talk about kinds from an early age. (b) Children should learn generic forms with only minimal parental scaffolding. (c) Children should recognize a variety of different linguistic forms as generic. Results from longitudinal samples of adult-child conversations support all three hypotheses. We also report individual differences in the use of generics, suggesting that children differ in their tendency to form the abstract generalizations so expressed. PMID:21765807

  9. Generic Language in Parent-Child Conversations

    PubMed Central

    Gelman, Susan A.; Goetz, Peggy J.; Sarnecka, Barbara W.; Flukes, Jonathan

    2011-01-01

    Generic knowledge concerns kinds of things (e.g., birds fly; a chair is for sitting; gold is a metal). Past research demonstrated that children spontaneously develop generic knowledge by preschool age. The present study examines when and how children learn to use the multiple devices provided by their language to express generic knowledge. We hypothesize that children assume, in the absence of specifying information or context, that nouns refer to generic kinds, as a default. Thus, we predict that (a) Children should talk about kinds from an early age. (b) Children should learn generic forms with only minimal parental scaffolding. (c) Children should recognize a variety of different linguistic forms as generic. Results from longitudinal samples of adult-child conversations support all three hypotheses. We also report individual differences in the use of generics, suggesting that children differ in their tendency to form the abstract generalizations so expressed. PMID:21765807

  10. SC'11 Poster: A Highly Efficient MGPT Implementation for LAMMPS; with Strong Scaling

    SciTech Connect

    Oppelstrup, T; Stukowski, A; Marian, J

    2011-12-07

    The MGPT potential has been implemented as a drop in package to the general molecular dynamics code LAMMPS. We implement an improved communication scheme that shrinks the communication layer thickness, and increases the load balancing. This results in unprecedented strong scaling, and speedup continuing beyond 1/8 atom/core. In addition, we have optimized the small matrix linear algebra with generic blocking (for all processors) and specific SIMD intrinsics for vectorization on Intel, AMD, and BlueGene CPUs.

  11. CO2 Reaction Induced Wettability Alteration and its Impacts on CO2 Storage: Pore to Core Scale Reservoir Condition Experimental Studies

    NASA Astrophysics Data System (ADS)

    Wan, J.; Tokunaga, T. K.; Kim, Y.; Jung, J.; Kim, T.; Dong, W.

    2013-12-01

    Wettability of the mineral surfaces plays an important role in subsurface multiphase flow and transport. Wettability affects the capillary pressure-saturation (Pc- S) relations, relative permeability (kr) of each fluid phase, and relative phase occupancy in reservoir pores. Although wettability issues have been studied extensively in other fields, significant knowledge gaps remain when applying the existing understanding to geological carbon sequestration; due largely to the unique physical-chemical properties of supercritical (sc) CO2 relative to other common non-wetting fluids such as air and oil. Here, we report our recent progress on wettability alteration upon reaction with CO2 and the resulting differences in capillary trapping of CO2 versus air. (1) Pore Scale Studies. There are conflict predictions in the literature concerning the effect of wettability on capillary trapping; some find that larger contact angles lead to lower capillary trapping while others have found opposite behavior. We hypothesized that spontaneous imbibition becomes energetically unfavorable with decreased wettability, so that increased residual trapping of scCO2 should occur during the post-injection inbibition stage. We developed a laboratory high-pressure and elevated temperature microscopic-micromodel system that is capable of controlling fine scale capillary pressure of scCO2-brine, and enabled us to conduct imbibition under controlled capillary pressures at the pore scale. We found that the de-wetting enhanced scCO2 capillary trapping is significant. These results suggest that scCO2 reaction induced dewetting can result in higher degrees of CO2 residual trapping in the post-injection stage than previously predicted. (2) Core Scale Studies. Capillary scaling is used routinely to predict Pc(S) relations for scCO2-brine systems at field scale, based on relations measured with air-water or mercury porosimetry. However, scaling-based predictions for CO2-brine systems have not been

  12. Long-distance relationship between large-scale tropical SSTs and ice core-derived oxygen isotopic records in the Third Pole Region

    NASA Astrophysics Data System (ADS)

    Thompson, L. G.; Yao, T.; Mosley-Thompson, E. S.; Lin, P.

    2012-12-01

    The tropical hydrological cycle is a key factor coupling isotopic records from ice core, speleothem and lake records with tropical SSTs and the vertical amplification of temperature in the Tropics. Stable isotopic ratios, particularly of oxygen, preserved in glacier ice provide high resolution records of climate changes over long time periods. In polar ice sheets the isotopic signal is driven primarily by temperature while in low-latitudes it depends on a variety of hydrologic and thermal influences in the broad geographic region that supplies moisture to the mountain glaciers. The strong correlation between ice core-derived isotopic records throughout the low- and mid-latitudes and tropical SSTs likely reflects the dominance of tropical evaporation in the flux of water vapor to the atmosphere and provides a possible explanation for the large-scale isotopic links among low- and mid-latitude paleoclimate records. Many low- to mid-latitude ice fields provide continuous, annually-resolved proxy records of climatic and environmental variability recorded by many preserved and measurable parameters including oxygen and hydrogen isotopic ratios and net mass balance (accumulation). These records present an opportunity to examine the nature of climate variability in these regions in greater detail and to extract new information about long-distance relationships in the climate system. Understanding these relationships is essential for proper interpretation of the isotopic records archived in glaciers, lakes, speleothems and other paleo-archives in the Third Pole (TP) Region. Here we compare high resolution records from Dasuopu Glacier in the Himalaya, a speleothem record from Wanxiang Cave in Gansu Province on the TP and the annually resolved ice core records from the Quelccaya Ice Cap in the tropical Andes of South America. The purpose is to explore the role of long-distance processes in determining the isotopic composition of paleo archives on the TP. Running correlations

  13. Scales

    SciTech Connect

    Murray Gibson

    2007-04-27

    Musical scales involve notes that, sounded simultaneously (chords), sound good together. The result is the left brain meeting the right brain — a Pythagorean interval of overlapping notes. This synergy would suggest less difference between the working of the right brain and the left brain than common wisdom would dictate. The pleasing sound of harmony comes when two notes share a common harmonic, meaning that their frequencies are in simple integer ratios, such as 3/2 (G/C) or 5/4 (E/C).

  14. Scales

    ScienceCinema

    Murray Gibson

    2016-07-12

    Musical scales involve notes that, sounded simultaneously (chords), sound good together. The result is the left brain meeting the right brain — a Pythagorean interval of overlapping notes. This synergy would suggest less difference between the working of the right brain and the left brain than common wisdom would dictate. The pleasing sound of harmony comes when two notes share a common harmonic, meaning that their frequencies are in simple integer ratios, such as 3/2 (G/C) or 5/4 (E/C).

  15. Ash deposits - Initiating the change from empiricism to generic engineering. Part 1: The generic approach

    SciTech Connect

    Wagoner, C.L.; Wessel, R.A.

    1986-01-01

    Empiricism has traditionally been used to relate laboratory and pilot-scale measurements of fuel characteristics with the design, performance, and the slagging and fouling behavior of steam generators. Currently, a new engineering approach is being evaluated. The goal is to develop and use calculations and measurements from several engineering disciplines that exceed the demonstrated limitations of present empirical techniques for predicting slagging/fouling behavior. In Part I of this paper, the generic approach to deposits and boiler performance is defined and a matrix of engineering concepts is described. General relationships are presented for assessing the effects of deposits and sootblowing on the real-time performance of heat transfer surfaces in pilot- and commercial-scale steam generators.

  16. Mercury's Core

    NASA Astrophysics Data System (ADS)

    Peale, S. J.

    2005-05-01

    In determining Mercury's core structure from its rotational properties, the location of Cassini state 1 is crucial. Convincing radar evidence indicates that the mantle rests on a liquid layer (Margot et al. 2005), but there are no empirical constraints on the moment of inertia C/MR2, which constraints must wait for the determination of the gravitational coefficients J2 and C22 from the MESSENGER orbiting spacecraft, and an accurate determination of the obliquity of the Cassini state. Tidal and core-mantle dissipation drive the spin to the Cassini state with a time scale O(105) years, so the spin should occupy the Cassini state and thereby define its obliquity---unless there has been a recent excitation of a free precession of the spin. Another way the spin might be displaced from the Cassini state is if the variations in the orbital elements, which change the position of the Cassini state, cause the spin axis to lag behind as it attempts to follow the state. Fortunately, the solid angle the spin axis encloses as it precesses around the Cassini state is an adiabatic invariant, and it is conserved if the orbital element variations are slow compared to the precession rate. As the precession period is O(1000) years, and the time scales of orbital parameter variations are O(105) years, the spin axis should remain very close to the Cassini state if it were ever close. But how close is close? The increasing precision of the radar and eventual spacecraft measurements warrants a check on the likely proximity of the spin axis to the Cassini state. By numerically following the positions of the spin axis and Cassini state with orbital parameters varying with time scales and amplitudes comparable to the real variations, we show that the spin should remain within 1″ of the Cassini state once dissipative torques bring it there. The current spin axis position should thus define the Cassini state sufficiently to put reasonably tight constraints on the core structure

  17. The early Cretaceous orogen-scale Dabieshan metamorphic core complex: implications for extensional collapse of the Triassic HP-UHP orogenic belt in east-central China

    NASA Astrophysics Data System (ADS)

    Ji, Wenbin; Lin, Wei; Faure, Michel; Shi, Yonghong; Wang, Qingchen

    2016-03-01

    The Dabieshan massif is famous as a portion of the world's largest HP-UHP metamorphic belt in east-central China that was built by the Triassic North-South China collision. The central domain of the Dabieshan massif is occupied by a huge migmatite-cored dome [i.e., the central Dabieshan dome (CDD)]. Origin of this domal structure remains controversial. Synthesizing previous and our new structural and geochronological data, we define the Cretaceous Dabieshan as an orogen-scale metamorphic core complex (MCC) with a multistage history. Onset of lithospheric extension in the Dabieshan area occurred as early as the commencement of crustal anatexis at the earliest Cretaceous (ca. 145 Ma), which was followed by primary (early-stage) detachment during 142-130 Ma. The central Dabieshan complex in the footwall and surrounding detachment faults recorded a consistently top-to-the-NW shearing. It is thus inferred that the primary detachment was initiated from a flat-lying detachment zone at the middle crust level. Removal of the orogenic root by delamination at ca. 130 Ma came into the extensional climax, and subsequently isostatic rebound resulted in rapid doming. Along with exhumation of the footwall, the mid-crustal detachment zone had been warped as shear zones around the CDD. After 120 Ma, the detachment system probably experienced a migration accommodated to the crustal adjustment, which led to secondary (late-stage) detachment with localized ductile shearing at ca. 110 Ma. The migmatite-gneiss with HP/UHP relicts in the CDD (i.e., the central Dabieshan complex) was product of the Cretaceous crustal anatexis that consumed the deep-seated part of the HP-UHP slices and the underlying para-autochthonous basement. Compared with the contemporaneous MCCs widely developed along the eastern margin of the Eurasian continent, we proposed that occurrence of the Dabieshan MCC shares the same tectonic setting as the "destruction of the North China craton". However, geodynamic trigger

  18. Generic Crystalline Disposal Reference Case

    SciTech Connect

    Painter, Scott Leroy; Chu, Shaoping; Harp, Dylan Robert; Perry, Frank Vinton; Wang, Yifeng

    2015-02-20

    A generic reference case for disposal of spent nuclear fuel and high-level radioactive waste in crystalline rock is outlined. The generic cases are intended to support development of disposal system modeling capability by establishing relevant baseline conditions and parameters. Establishment of a generic reference case requires that the emplacement concept, waste inventory, waste form, waste package, backfill/buffer properties, EBS failure scenarios, host rock properties, and biosphere be specified. The focus in this report is on those elements that are unique to crystalline disposal, especially the geosphere representation. Three emplacement concepts are suggested for further analyses: a waste packages containing 4 PWR assemblies emplaced in boreholes in the floors of tunnels (KBS-3 concept), a 12-assembly waste package emplaced in tunnels, and a 32-assembly dual purpose canister emplaced in tunnels. In addition, three failure scenarios were suggested for future use: a nominal scenario involving corrosion of the waste package in the tunnel emplacement concepts, a manufacturing defect scenario applicable to the KBS-3 concept, and a disruptive glaciation scenario applicable to both emplacement concepts. The computational approaches required to analyze EBS failure and transport processes in a crystalline rock repository are similar to those of argillite/shale, with the most significant difference being that the EBS in a crystalline rock repository will likely experience highly heterogeneous flow rates, which should be represented in the model. The computational approaches required to analyze radionuclide transport in the natural system are very different because of the highly channelized nature of fracture flow. Computational workflows tailored to crystalline rock based on discrete transport pathways extracted from discrete fracture network models are recommended.

  19. GLAD: A Generic LAttice Debugger

    SciTech Connect

    Lee, M.J.

    1991-11-01

    Today, numerous simulation and analysis codes exist for the design, commission, and operation of accelerator beam lines. There is a need to develop a common user interface and database link to run these codes interactively. This paper will describe a proposed system, GLAD (Generic LAttice Debugger), to fulfill this need. Specifically, GLAD can be used to find errors in beam lines during commissioning, control beam parameters during operation, and design beam line optics and error correction systems for the next generation of linear accelerators and storage rings.

  20. Generic thin-shell gravastars

    SciTech Connect

    Martin-Moruno, Prado; Visser, Matt; Garcia, Nadiezhda Montelongo; Lobo, Francisco S.N. E-mail: nmontelongo@fis.cinvestav.mx E-mail: matt.visser@msor.vuw.ac.nz

    2012-03-01

    We construct generic spherically symmetric thin-shell gravastars by using the cut-and-paste procedure. We take considerable effort to make the analysis as general and unified as practicable; investigating both the internal physics of the transition layer and its interaction with 'external forces' arising due to interactions between the transition layer and the bulk spacetime. Furthermore, we discuss both the dynamic and static situations. In particular, we consider 'bounded excursion' dynamical configurations, and probe the stability of static configurations. For gravastars there is always a particularly compelling configuration in which the surface energy density is zero, while surface tension is nonzero.

  1. Descriptive Model of Generic WAMS

    SciTech Connect

    Hauer, John F.; DeSteese, John G.

    2007-06-01

    The Department of Energy’s (DOE) Transmission Reliability Program is supporting the research, deployment, and demonstration of various wide area measurement system (WAMS) technologies to enhance the reliability of the Nation’s electrical power grid. Pacific Northwest National Laboratory (PNNL) was tasked by the DOE National SCADA Test Bed Program to conduct a study of WAMS security. This report represents achievement of the milestone to develop a generic WAMS model description that will provide a basis for the security analysis planned in the next phase of this study.

  2. Seasonal climate information preserved within West Antarctic ice cores and its relation to large-scale atmospheric circulation and regional sea ice variations

    NASA Astrophysics Data System (ADS)

    Küttel, M.; Steig, E. J.; Ding, Q.; Battisti, D. S.

    2010-12-01

    Recent evidence suggests that West Antarctica has been warming since at least the 1950s. With the instrumental record being limited to the mid-20th century, indirect information from stable isotopes (δ18O and δD, hereafter collectively δ) preserved within ice cores have commonly been used to place this warming into a long term context. Here, using a large number of δ records obtained during the International Trans-Antarctic Scientific Expedition (ITASE), past variations in West Antarctic δ are not only investigated over time but also in space. This study therefore provides an important complement to longer records from single locations as e.g. the currently being processed West Antarctic ice sheet (WAIS) Divide ice core. Although snow accumulation rates at the ITASE sites in West Antarctica are variable, they are generally high enough to allow studies on sub-annual scale over the last 50-100 years. Here, we show that variations in δ in this region are strongly related to the state of the large-scale atmospheric circulation as well as sea ice variations in the adjacent Southern Ocean, with important seasonal changes. While a strong relationship to sea ice changes in the Ross and Amundsen Sea as well as to the atmospheric circulation offshore is found during austral fall (MAM) and winter (JJA), only modest correlations are found during spring (SON) and summer (DJF). Interestingly, the correlations with the atmospheric circulation in the latter two seasons have the strongest signal over the Antarctic continent, but not offshore - an important difference to MAM and JJA. These seasonal changes are in good agreement with the seasonally varying predominant circulation: meridional with more frequent storms in the Amundsen Sea during MAM and JJA and more zonal and stable during SON and DJF. The relationship to regional temperature is similarly seasonally variable with highest correlations found during MAM and JJA. Notably, the circulation pattern found to be strongest

  3. Large-scale fabrication of polymer/Ag core-shell nanorod array as flexible SERS substrate by combining direct nanoimprint and electroless deposition

    NASA Astrophysics Data System (ADS)

    Liu, Sisi; Xu, Zhimou; Sun, Tangyou; Zhao, Wenning; Wu, Xinghui; Ma, Zhichao; Xu, Haifeng; He, Jian; Chen, Cunhua

    2014-06-01

    We demonstrate a highly sensitive surface-enhanced Raman scattering (SERS) substrate, which consists of Ag nanoparticles (NPs) assembled on the surface of a nanopatterned polymer film. The fabrication route of a polymer/Ag core-shell nanorod (PACSN) array employed a direct nanoimprint technique to create a high-resolution polymer nanorod array. The obtained nanopatterned polymer film was subjected to electroless deposition to form a sea-cucumber-like Ag shell over the surface of the polymer nanorod. The morphology and structures of PACSNs were analyzed by using scanning electron microscopy and X-ray diffraction. The as-synthesized PACSNs exhibited a remarkable SERS activity and Raman signal reproducibility to rhodamine 6G, and a concentration down to 10-12 M can be identified. The effect of electroless deposition time of Ag NPs onto the polymer nanorod surface was investigated. It was found that the electroless deposition time played an important role in SERS activity. Our results revealed that the combination of direct nanoimprint and electroless deposition provided a convenient and cost-effective way for large-scale fabrication of reliable SERS substrates without the requirement of expensive instruments.

  4. Toward a generic UGV autopilot

    NASA Astrophysics Data System (ADS)

    Moore, Kevin L.; Whitehorn, Mark; Weinstein, Alejandro J.; Xia, Junjun

    2009-05-01

    Much of the success of small unmanned air vehicles (UAVs) has arguably been due to the widespread availability of low-cost, portable autopilots. While the development of unmanned ground vehicles (UGVs) has led to significant achievements, as typified by recent grand challenge events, to date the UGV equivalent of the UAV autopilot is not available. In this paper we describe our recent research aimed at the development of a generic UGV autopilot. Assuming we are given a drive-by-wire vehicle that accepts as inputs steering, brake, and throttle commands, we present a system that adds sonar ranging sensors, GPS/IMU/odometry, stereo camera, and scanning laser sensors, together with a variety of interfacing and communication hardware. The system also includes a finite state machine-based software architecture as well as a graphical user interface for the operator control unit (OCU). Algorithms are presented that enable an end-to-end scenario whereby an operator can view stereo images as seen by the vehicle and can input GPS waypoints either from a map or in the vehicle's scene-view image, at which point the system uses the environmental sensors as inputs to a Kalman filter for pose estimation and then computes control actions to move through the waypoint list, while avoiding obstacles. The long-term goal of the research is a system that is generically applicable to any drive-by-wire unmanned ground vehicle.

  5. Generic Hypersonic Inlet Module Analysis

    NASA Technical Reports Server (NTRS)

    Cockrell, Chares E., Jr.; Huebner, Lawrence D.

    2004-01-01

    A computational study associated with an internal inlet drag analysis was performed for a generic hypersonic inlet module. The purpose of this study was to determine the feasibility of computing the internal drag force for a generic scramjet engine module using computational methods. The computational study consisted of obtaining two-dimensional (2D) and three-dimensional (3D) computational fluid dynamics (CFD) solutions using the Euler and parabolized Navier-Stokes (PNS) equations. The solution accuracy was assessed by comparisons with experimental pitot pressure data. The CFD analysis indicates that the 3D PNS solutions show the best agreement with experimental pitot pressure data. The internal inlet drag analysis consisted of obtaining drag force predictions based on experimental data and 3D CFD solutions. A comparative assessment of each of the drag prediction methods is made and the sensitivity of CFD drag values to computational procedures is documented. The analysis indicates that the CFD drag predictions are highly sensitive to the computational procedure used.

  6. Generic Airspace Concepts and Research

    NASA Technical Reports Server (NTRS)

    Mogford, Richard H.

    2010-01-01

    The purpose of this study was to evaluate methods for reducing the training and memorization required to manage air traffic in mid-term, Next Generation Air Transportation System (NextGen) airspace. We contrasted the performance of controllers using a sector information display and NextGen automation tools while working with familiar and unfamiliar sectors. The airspace included five sectors from Oakland and Salt Lake City Centers configured as a "generic center" called "West High Center." The Controller Information Tool was used to present essential information for managing these sectors. The Multi Aircraft Control System air traffic control simulator provided data link and conflict detection and resolution. There were five experienced air traffic controller participants. Each was familiar with one or two of the five sectors, but not the others. The participants rotated through all five sectors during the ten data collection runs. The results addressing workload, traffic management, and safety, as well as controller and observer comments, supported the generic sector concept. The unfamiliar sectors were comparable to the familiar sectors on all relevant measures.

  7. The use of generic medications for hepatitis C.

    PubMed

    Freeman, James A D; Hill, Andrew

    2016-07-01

    Hepatitis C, hepatitis B, HIV, TB and malaria are the five major causes of infectious disease death worldwide. In a breakthrough that rivals the invention of penicillin, drugs that cure hepatitis C, with minimal side effects and high success rates, have reached the market, but, in what must be one of the greatest tragedies of modern times, these life-saving medications are not being deployed on a mass scale. Pharmaceutical patents are gifted to private corporations by governments for the dual purposes of protecting R&D expenditure and encouraging innovation. Unfortunately the monopoly pricing power these patents provision currently lacks adequate checks and balances, is open to abuse, and is quite clearly being abused. The sort of legislative changes required to deliver on the original goals of pharmaceutical patents will take years or even decades to eventuate. Parallel importation of generic medication offers hope to the millions of patients with HCV unable to afford access to vastly overpriced originator medications. Doctors prescribing and monitoring patients taking generics can take comfort from the fact that the REDEMPTION trial results show, like the HIV generics that came before them, that HCV generics deliver robust clinical results. PMID:27306303

  8. Generic domain models in software engineering

    NASA Technical Reports Server (NTRS)

    Maiden, Neil

    1992-01-01

    This paper outlines three research directions related to domain-specific software development: (1) reuse of generic models for domain-specific software development; (2) empirical evidence to determine these generic models, namely elicitation of mental knowledge schema possessed by expert software developers; and (3) exploitation of generic domain models to assist modelling of specific applications. It focuses on knowledge acquisition for domain-specific software development, with emphasis on tool support for the most important phases of software development.

  9. Higher-order generic functions for CLOS

    SciTech Connect

    Hernandez, J.E.

    1992-03-01

    This paper presents a framework for developing higher-order generic functions within the Common Lisp Object System similar to the ones in Common Lisp for processing sequences. The framework consist of several CLOS classes which define a protocol that allows other classes to inherit default methods for many higher-order generic functions. These generic functions provide an elegant and uniform framework for processing CLOS objects that primarily represent collections of other objects.

  10. Composite Cores

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Spang & Company's new configuration of converter transformer cores is a composite of gapped and ungapped cores assembled together in concentric relationship. The net effect of the composite design is to combine the protection from saturation offered by the gapped core with the lower magnetizing requirement of the ungapped core. The uncut core functions under normal operating conditions and the cut core takes over during abnormal operation to prevent power surges and their potentially destructive effect on transistors. Principal customers are aerospace and defense manufacturers. Cores also have applicability in commercial products where precise power regulation is required, as in the power supplies for large mainframe computers.

  11. Generic drugs and the prescribing physician.

    PubMed

    Nightingale, S L; Morrison, J C

    1987-09-01

    While generic substitution is not a new phenomenon, a number of factors have combined to markedly increase generic drug use. The most important factor is a 1984 law, the Drug Price Competition and Patent Term Restoration Act, which facilitates the entry into the marketplace of generic versions of brand name drugs. This law and Food and Drug Administration (FDA) policies are designed to approve for marketing generic drug products that are therapeutically equivalent to their brand name counterparts. With increased availability of generic drugs, physicians have expressed the need for more information about the FDA process for determining that generic versions of brand name drug products are both safe and effective and that generic drug products will produce the same therapeutic results as those achieved by the brand name products. This article describes FDA procedures for approving generic drug products and examines issues important to the prescribing physician, in particular, therapeutic equivalence. The article also describes the role of the states in generic substitution and the availability of information from the FDA on the therapeutic equivalence of drug products.

  12. Rational use of generic psychotropic drugs.

    PubMed

    Carbon, Maren; Correll, Christoph U

    2013-05-01

    For economic reasons, the generic substitution of branded medications is common and welcome. These replacements are based on the concept of bioequivalence, which is considered equal to therapeutic equivalence. Regulatory standards for bioequivalence require the 90 % confidence intervals of group averages of pharmacokinetic measures of a generic and the original drug to overlap within ±20 %. However, therapeutic equivalence has been challenged for several psychotropic agents by retrospective studies and case reports. To evaluate the degree of bioequivalence and therapeutic equivalence of branded and generic psychotropic drugs, we performed an electronic search (from database inception until 24 May 2012 and without language restrictions) in PubMed/MEDLINE, Cochrane Library, and Web of Science. Search terms were "(generic) AND (psychotropic OR psychoactive OR antipsychotic OR antiepileptic OR antidepressant OR stimulant OR benzodiazepine)" or the respective individual substances. We included clinical studies, regardless of design, comparing branded with generic psychotropic drug formulations, identifying 35 such studies. We also included case reports/series reporting on outcomes after a switch between brand and generic psychotropics, identifying 145 clinical cases. Bioequivalence studies in healthy controls or animals, in-vitro studies, and health economics studies without medical information were excluded. An overview of the few randomized controlled studies supports that US FDA regulations assure clinically adequate drug delivery in the majority of patients switched from brand to generic. However, with a growing number of competing generic products for one substance, and growing economic pressure to substitute with the currently cheapest generic, frequent generic-generic switches, often unbeknownst to prescribing clinicians, raise concerns, particularly for antiepileptics/mood stabilizers. Generic-generic switches may vary by more than ±20 % from each other in

  13. Analysis of French generic medicines retail market: why the use of generic medicines is limited.

    PubMed

    Dylst, Pieter; Vulto, Arnold; Simoens, Steven

    2014-12-01

    The market share of generic medicines in France is low compared to other European countries. This perspective paper provides an overview of the generic medicines retail market in France and how the current policy environment may affect the long-term sustainability. Looking at the French generic medicines retail market and the surrounding regulatory framework, all conditions seem to be in place to create a healthy generic medicines market: the country has well-respected regulatory authorities, generic medicines enter the market in a timely manner and prices of generic medicines are competitive compared with other European countries. Despite the success of the demand-side policies targeted at pharmacists and patients, those targeted at physicians were less successful due to a lack of enforcement and a lack of trust in generic medicines by French physicians. Recommendations to increase the use of generic medicines in France round off this perspective paper.

  14. Pharmaceutical policy regarding generic drugs in Belgium.

    PubMed

    Simoens, Steven; De Bruyn, Kristien; Bogaert, Marc; Laekeman, Gert

    2005-01-01

    Pressure to control pharmaceutical expenditure and price competition among pharmaceutical companies are fuelling the development of generic drug markets in EU countries. However, in Belgium, the market for generic drugs is underdeveloped compared with other countries. To promote the use of generic drugs, the government introduced a reference pricing (RP) scheme in 2001. The aim of this paper is to discuss Belgian pharmaceutical policy regarding generic drugs and to analyse how the Belgian drug market has evolved following initiation of the RP scheme. The market share held by generic drugs increased following implementation of the RP scheme. Focusing on volume, average market share (by semester) for generic drugs amounted to 2.05% of the total pharmaceutical market from January 1998 to June 2001, compared with 6.11% from July 2001 to December 2003. As new generic drugs are introduced, their market share tends to increase in the first couple of months, after which it levels off. Faced with increasing generic competition, some manufacturers have launched new variants of their original drug, thereby effectively extending the period of patent protection. Strategies consisting of price reductions in return for the abolition of prescribing conditions and the launch of new dosages or formulations appear to have been successful in maintaining the market share of original drugs. Nevertheless, the introduction of the RP scheme was associated with savings amounting to 1.8% of pharmaceutical expenditure by the third-party payer in 2001 and 2.1% in 2002. The findings of this paper indicate that the RP scheme has stimulated the Belgian generic drug market. However, existing policy has largely failed to take into account the role that physicians and pharmacists can play in stimulating generic drug use. Therefore, further development of the Belgian generic drug market seems to hinge on the creation of appropriate incentives for physicians to prescribe, and for pharmacists to

  15. Children's generic interpretation of pretense.

    PubMed

    Baer, Carolyn; Friedman, Ori

    2016-10-01

    We report two experiments investigating how 3- to 5-year-olds learn general knowledge from pretend play-how they learn about kinds of things (e.g., information about dogs) from information about particular individuals in pretend play (a certain dog in a pretend scenario). Children watched pretend-play enactments in which animals showed certain behaviors or heard utterances conveying the same information. When children were subsequently asked about who shows the behavior, children who watched pretend play were more likely to give generic responses than were children who heard the utterances. These findings show that children generalize information from pretend play to kinds even without being prompted to think about kinds, that pretend play can be informative about familiar kinds, and also that pretend play is a more potent source for general knowledge than are utterances about individuals. PMID:27268159

  16. Children's generic interpretation of pretense.

    PubMed

    Baer, Carolyn; Friedman, Ori

    2016-10-01

    We report two experiments investigating how 3- to 5-year-olds learn general knowledge from pretend play-how they learn about kinds of things (e.g., information about dogs) from information about particular individuals in pretend play (a certain dog in a pretend scenario). Children watched pretend-play enactments in which animals showed certain behaviors or heard utterances conveying the same information. When children were subsequently asked about who shows the behavior, children who watched pretend play were more likely to give generic responses than were children who heard the utterances. These findings show that children generalize information from pretend play to kinds even without being prompted to think about kinds, that pretend play can be informative about familiar kinds, and also that pretend play is a more potent source for general knowledge than are utterances about individuals.

  17. Generic Propellants Transfer Unit (GPTU)

    NASA Technical Reports Server (NTRS)

    Cook, Christopher A.

    1992-01-01

    The Generic Propellants Transfer Unit (GPTU) is being designed to support spacecraft liquid propellant operations at the Kennedy Space Center (KSC) and Eastern Test Range (ETR). The GPTU will have a 500 gallon capacity and be Department Of Transportation (DOT) approved for over-the-road transportation of hypergolic propellants. The use of these containers will allow the users to increase efficiency and reduce the following costs: design/construction, transportation (to/from the launch site), propellant transfer operations, and decontamination operations. The user also acquires the flexibility of transporting to an offsite location for processing or storage without obtaining special exemptions or permits. These containers will incorporate their own quantity gaging and temperature sensing systems, and be integrated onto a transport trailer which contains work platforms and a fluid transfer system.

  18. Performance Assessment Modeling and Sensitivity Analyses of Generic Disposal System Concepts.

    SciTech Connect

    Sevougian, S. David; Freeze, Geoffrey A.; Gardner, William Payton; Hammond, Glenn Edward; Mariner, Paul

    2014-09-01

    directly, rather than through simplified abstractions. It also a llows for complex representations of the source term, e.g., the explicit representation of many individual waste packages (i.e., meter - scale detail of an entire waste emplacement drift). This report fulfills the Generic Disposal System Analysis Work Packa ge Level 3 Milestone - Performance Assessment Modeling and Sensitivity Analyses of Generic Disposal System Concepts (M 3 FT - 1 4 SN08080 3 2 ).

  19. Hollow-Core Fiber Lamp

    NASA Technical Reports Server (NTRS)

    Yi, Lin (Inventor); Tjoelker, Robert L. (Inventor); Burt, Eric A. (Inventor); Huang, Shouhua (Inventor)

    2016-01-01

    Hollow-core capillary discharge lamps on the millimeter or sub-millimeter scale are provided. The hollow-core capillary discharge lamps achieve an increased light intensity ratio between 194 millimeters (useful) and 254 millimeters (useless) light than conventional lamps. The capillary discharge lamps may include a cone to increase light output. Hollow-core photonic crystal fiber (HCPCF) may also be used.

  20. Comparison of speleothem δ 18O records from eastern China with solar insolation, ice core and marine records: Similarities and discrepancies on different time scales

    NASA Astrophysics Data System (ADS)

    Wan, Naijung; Chung, Weiling; Li, Hong-Chun; Lin, Huilin; Ku, Teh-Lung; Shen, Chuan-Chou; Yuan, Daoxian; Zhang, Meiliang; Lin, Yushi

    2011-04-01

    Four 230Th-dated δ 18O records in three stalagmites: one from Dragon Spring (stalagmite L12) and two from Golden Lion Caves (stalagmites JSD-01 and JSD-02) located in Libo County, southeast Guizhou, China, are presented. These records cover age ranges of 0.75-2 ka (late Holocene), 9-9.6 ka (early Holocene), 87.9-88.2 ka and 93.8-95.2 ka (late Pleistocene). They fit well with the published Dongge Cave record from the same area, where the climate has been much influenced by the East Asian Monsoon. The agreement reinforces the role of stalagmite δ 18O as a proxy for regional precipitation or monsoon strength. On millennial or longer time scales, the δ 18O record of Dongge Cave resembles those of Sanbao Cave in Hubei and Hulu Cave in Jiangsu of China. The matching of these records with the northern hemisphere solar-insolation variations points to the importance of insolation in affecting the East Asian Summer Monsoon strength on 10 3-10 4-yr scales. While the monsoon variations as depicted by these Chinese speleothem δ 18O records show a strong coupling to insolation's precession component (23-kyr period), other climate records of global significance extracted from oceanic and terrestrial deposits (e.g., deep-sea sediments, polar ice cores, cave deposits from non-monsoonal regions) do not. Although the latter records were thought to be also influenced by the large changes in global ice volume, they show variations modulated chiefly by insolation due to earth's eccentricity change (100-kyr period). It is hypothesized that precession variations control the distribution of solar insolation between the northern and southern hemispheres, the ITCZ position and the modulation of low-latitude summer monsoon variability. Increasing rainfall and/or summer/winter precipitation ratio brought about by strong summer monsoons leads to δ 18O depletion in stalagmites grown in monsoonal regions. One should use caution to compare speleothem δ 18O records with other paleoclimate

  1. Developmental Changes in the Understanding of Generics

    ERIC Educational Resources Information Center

    Gelman, Susan A.; Bloom, Paul

    2007-01-01

    Generic sentences (such as "Birds lay eggs") are important in that they refer to kinds (e.g., birds as a group) rather than individuals (e.g., the birds in the henhouse). The present set of studies examined aspects of how generic nouns are understood by English speakers. Adults and children (4- and 5-year-olds) were presented with scenarios about…

  2. HTGR generic technology program plan (FY 80)

    SciTech Connect

    Not Available

    1980-01-01

    Purpose of the program is to develop base technology and to perform design and development common to the HTGR Steam Cycle, Gas Turbine, and Process Heat Plants. The generic technology program breaks into the base technology, generic component, pebble-bed study, technology transfer, and fresh fuel programs. (DLC)

  3. Generic Proving: Reflections on Scope and Method

    ERIC Educational Resources Information Center

    Leron, Uri; Zaslavsky, Orit

    2013-01-01

    We analyze the role of generic proofs in helping students access difficult proofs more easily and naturally. We present three examples of generic proving--an elementary one on numbers, a more advanced one on permutations, and yet more advanced one on groups--and consider the affordances and pitfalls of the method by reflecting on these examples. A…

  4. Generic Language Facilitates Children's Cross-Classification

    ERIC Educational Resources Information Center

    Nguyen, Simone P.; Gelman, A.

    2012-01-01

    Four studies examined the role of generic language in facilitating 4- and 5-year-old children's ability to cross-classify. Participants were asked to classify an item into a familiar (taxonomic or script) category, then cross-classify it into a novel (script or taxonomic) category with the help of a clue expressed in either generic or specific…

  5. Generic Skills. Keys to Job Performance.

    ERIC Educational Resources Information Center

    Smith, Arthur De W.

    The generic skills studies in Canada have as their objectives the formulation of generic skills, the identification of their uses for certain occupational groups, and the preparation of specifications for instructional modules in an attempt to provide greater flexibility to workers, employers, and vocational training programs. Another objective of…

  6. Children's Interpretation of Generic Noun Phrases.

    ERIC Educational Resources Information Center

    Hollander, Michelle A.; Gelman, Susan A.; Star, Jon

    2002-01-01

    Two studies used a comprehension task and an elicited production task to examine whether preschool children and adults appreciated the semantic properties of generic utterances. Findings indicated that in both tasks, 4-year-olds and adults treated generics ("bears live in caves") as distinct from both indefinites ("some") and universal quantifiers…

  7. 40 CFR 721.545 - Polyalkenylalkylphenol (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.545 Polyalkenylalkylphenol (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a Polyalkenylalkylphenol (PMN...

  8. 40 CFR 721.450 - Hydrofluorochloroalkene (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.450 Hydrofluorochloroalkene (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a hydrofluorochloroalkene...

  9. 40 CFR 721.450 - Hydrofluorochloroalkene (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.450 Hydrofluorochloroalkene (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a hydrofluorochloroalkene...

  10. 40 CFR 721.545 - Polyalkenylalkylphenol (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.545 Polyalkenylalkylphenol (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a Polyalkenylalkylphenol (PMN...

  11. [Should the ophthalmologist prescribe generic drugs?].

    PubMed

    Nordmann, J-P

    2003-10-01

    It seems obvious that an ophthalmologist should encourage the use of generic drugs. However, it is important to know the exact definition of a generic drug and the type of studies to be conducted before a generic drug is released on the market. A generic drug is a drug that has the same composition quantitatively as well as qualitatively of the active compound as the original drug. It also has the same pharmaceutical mode of action and the same bioavailability, as determined with bioavailability studies. Ophthalmic drops contain both an active compound and many adjuvants used to stabilize the drug. Globally speaking, the active compound corresponds to the efficacy of a topical drug and the adjuvant to its tolerance. It is likely that the efficacy of a generic drug is identical to that of the brand-name drug, even though only bioavailability studies in non-human models are required to evaluate tolerance which is less likely to be identical, as adjuvants can differ. A survey of 520 French ophthalmologists has recently been conducted. It shows that doctors rarely think of prescribing generic drugs, as they do not consider cost as a major issue in treating glaucoma. However, they see no reason not to prescribe generic drugs. This mixed perception is shared by patients who willingly accept that doctors prescribe a generic drug, but do not wish the pharmacist to take the initiative of filling a prescription with a generic drug, which sometimes gives patients the impression of being less well treated. The use of generic drugs should be encouraged, keeping in mind that good tolerance should be ensured. PMID:14646825

  12. Generic statements require little evidence for acceptance but have powerful implications

    PubMed Central

    Cimpian, Andrei; Brandone, Amanda C.; Gelman, Susan A.

    2010-01-01

    Generic statements (e.g., “Birds lay eggs”) express generalizations about categories. In this paper, we hypothesized that there is a paradoxical asymmetry at the core of generic meaning, such that these sentences have extremely strong implications but require little evidence to be judged true. Four experiments confirmed the hypothesized asymmetry: Participants interpreted novel generics such as “Lorches have purple feathers” as referring to nearly all lorches, but they judged the same novel generics to be true given a wide range of prevalence levels (e.g., even when only 10% or 30% of lorches had purple feathers). A second hypothesis, also confirmed by the results, was that novel generic sentences about dangerous or distinctive properties would be more acceptable than generic sentences that were similar but did not have these connotations. In addition to clarifying important aspects of generics’ meaning, these findings are applicable to a range of real-world processes such as stereotyping and political discourse. PMID:21116475

  13. Generic Magnetic Fusion Reactor Revisited

    NASA Astrophysics Data System (ADS)

    Sheffield, John; Milora, Stanley

    2015-11-01

    The original Generic Magnetic Fusion Reactor paper was published in 1986. This update describes what has changed in 30 years. Notably, the construction of ITER is providing important benchmark numbers for technologies and costs. In addition, we use a more conservative neutron wall flux and fluence. But these cost-increasing factors are offset by greater optimism on the thermal-electric conversion efficiency and potential availability. The main examples show the cost of electricity (COE) as a function of aspect ratio and neutron flux to the first wall. The dependence of the COE on availability, thermo-electric efficiency, electrical power output, and the present day's low interest rates is also discussed. Interestingly, at fixed aspect ratio there is a shallow minimum in the COE at neutron flux around 2.5 MW/m2. The possibility of operating with only a small COE penalty at even lower wall loadings (to 1.0 MW/m2 at larger plant size) and the use of niobium-titanium coils are also investigated. J. Sheffield was supported by ORNL subcontract 4000088999 with the University of Tennessee.

  14. Generic theory for channel sinuosity

    PubMed Central

    Lazarus, Eli D.; Constantine, José Antonio

    2013-01-01

    Sinuous patterns traced by fluid flows are a ubiquitous feature of physical landscapes on Earth, Mars, the volcanic floodplains of the Moon and Venus, and other planetary bodies. Typically discussed as a consequence of migration processes in meandering rivers, sinuosity is also expressed in channel types that show little or no indication of meandering. Sinuosity is sometimes described as “inherited” from a preexisting morphology, which still does not explain where the inherited sinuosity came from. For a phenomenon so universal as sinuosity, existing models of channelized flows do not explain the occurrence of sinuosity in the full variety of settings in which it manifests, or how sinuosity may originate. Here we present a generic theory for sinuous flow patterns in landscapes. Using observations from nature and a numerical model of flow routing, we propose that flow resistance (representing landscape roughness attributable to topography or vegetation density) relative to surface slope exerts a fundamental control on channel sinuosity that is effectively independent of internal flow dynamics. Resistance-dominated surfaces produce channels with higher sinuosity than those of slope-dominated surfaces because increased resistance impedes downslope flow. Not limited to rivers, the hypothesis we explore pertains to sinuosity as a geomorphic pattern. The explanation we propose is inclusive enough to account for a wide variety of sinuous channel types in nature, and can serve as an analytical tool for determining the sinuosity a landscape might support. PMID:23610390

  15. Generic physical protection logic trees

    SciTech Connect

    Paulus, W.K.

    1981-10-01

    Generic physical protection logic trees, designed for application to nuclear facilities and materials, are presented together with a method of qualitative evaluation of the trees for design and analysis of physical protection systems. One or more defense zones are defined where adversaries interact with the physical protection system. Logic trees that are needed to describe the possible scenarios within a defense zone are selected. Elements of a postulated or existing physical protection system are tagged to the primary events of the logic tree. The likelihood of adversary success in overcoming these elements is evaluated on a binary, yes/no basis. The effect of these evaluations is propagated through the logic of each tree to determine whether the adversary is likely to accomplish the end event of the tree. The physical protection system must be highly likely to overcome the adversary before he accomplishes his objective. The evaluation must be conducted for all significant states of the site. Deficiencies uncovered become inputs to redesign and further analysis, closing the loop on the design/analysis cycle.

  16. Generic OPC UA Server Framework

    NASA Astrophysics Data System (ADS)

    Nikiel, Piotr P.; Farnham, Benjamin; Filimonov, Viatcheslav; Schlenker, Stefan

    2015-12-01

    This paper describes a new approach for generic design and efficient development of OPC UA servers. Development starts with creation of a design file, in XML format, describing an object-oriented information model of the target system or device. Using this model, the framework generates an executable OPC UA server application, which exposes the per-design OPC UA address space, without the developer writing a single line of code. Furthermore, the framework generates skeleton code into which the developer adds the necessary logic for integration to the target system or device. This approach allows both developers unfamiliar with the OPC UA standard, and advanced OPC UA developers, to create servers for the systems they are experts in while greatly reducing design and development effort as compared to developments based purely on COTS OPC UA toolkits. Higher level software may further benefit from the explicit OPC UA server model by using the XML design description as the basis for generating client connectivity configuration and server data representation. Moreover, having the XML design description at hand facilitates automatic generation of validation tools. In this contribution, the concept and implementation of this framework is detailed along with examples of actual production-level usage in the detector control system of the ATLAS experiment at CERN and beyond.

  17. Distinguishability of generic quantum states

    NASA Astrophysics Data System (ADS)

    Puchała, Zbigniew; Pawela, Łukasz; Życzkowski, Karol

    2016-06-01

    Properties of random mixed states of dimension N distributed uniformly with respect to the Hilbert-Schmidt measure are investigated. We show that for large N , due to the concentration of measure, the trace distance between two random states tends to a fixed number D ˜=1 /4 +1 /π , which yields the Helstrom bound on their distinguishability. To arrive at this result, we apply free random calculus and derive the symmetrized Marchenko-Pastur distribution, which is shown to describe numerical data for the model of coupled quantum kicked tops. Asymptotic value for the root fidelity between two random states, √{F }=3/4 , can serve as a universal reference value for further theoretical and experimental studies. Analogous results for quantum relative entropy and Chernoff quantity provide other bounds on the distinguishablity of both states in a multiple measurement setup due to the quantum Sanov theorem. We study also mean entropy of coherence of random pure and mixed states and entanglement of a generic mixed state of a bipartite system.

  18. Aerodynamic and acoustic effects of eliminating core swirl from a full scale 1.6 stage pressure ratio fan (QF-5A)

    NASA Technical Reports Server (NTRS)

    Woodward, R. P.; Acker, L. W.; Stakolich, E. G.

    1978-01-01

    Fan QF-5A was a modification of fan QF-5 which had an additional core stator and adjusted support struts to turn the core exit flow from a 30 deg swirl to the axial direction. This modification was necessary to eliminate the impingement of the swirling core flow on the axial support pylon of the NASA-Lewis Quiet Fan Facility that caused aerodynamic, acoustic and structural problems with the original fan stage at fan speeds greater than 85 percent of design. The redesigned fan QF-5A did obtain the design bypass ratio with an increased core airflow suggesting that the flow problem was resolved. Acoustically, the redesigned stage showed a low frequency broadband noise reduction compared to the results for fan QF-5 at similar operating conditions.

  19. Generic Argillite/Shale Disposal Reference Case

    SciTech Connect

    Zheng, Liange; Colon, Carlos Jové; Bianchi, Marco; Birkholzer, Jens

    2014-08-08

    Radioactive waste disposal in a deep subsurface repository hosted in clay/shale/argillite is a subject of widespread interest given the desirable isolation properties, geochemically reduced conditions, and widespread geologic occurrence of this rock type (Hansen 2010; Bianchi et al. 2013). Bianchi et al. (2013) provides a description of diffusion in a clay-hosted repository based on single-phase flow and full saturation using parametric data from documented studies in Europe (e.g., ANDRA 2005). The predominance of diffusive transport and sorption phenomena in this clay media are key attributes to impede radionuclide mobility making clay rock formations target sites for disposal of high-level radioactive waste. The reports by Hansen et al. (2010) and those from numerous studies in clay-hosted underground research laboratories (URLs) in Belgium, France and Switzerland outline the extensive scientific knowledge obtained to assess long-term clay/shale/argillite repository isolation performance of nuclear waste. In the past several years under the UFDC, various kinds of models have been developed for argillite repository to demonstrate the model capability, understand the spatial and temporal alteration of the repository, and evaluate different scenarios. These models include the coupled Thermal-Hydrological-Mechanical (THM) and Thermal-Hydrological-Mechanical-Chemical (THMC) models (e.g. Liu et al. 2013; Rutqvist et al. 2014a, Zheng et al. 2014a) that focus on THMC processes in the Engineered Barrier System (EBS) bentonite and argillite host hock, the large scale hydrogeologic model (Bianchi et al. 2014) that investigates the hydraulic connection between an emplacement drift and surrounding hydrogeological units, and Disposal Systems Evaluation Framework (DSEF) models (Greenberg et al. 2013) that evaluate thermal evolution in the host rock approximated as a thermal conduction process to facilitate the analysis of design options. However, the assumptions and the

  20. GEOS-CORE

    SciTech Connect

    2014-06-24

    GEOS-CORE is a code that integrates open source Libraries for linear algebra and I/O with two main LLNL-written components: (i) a set of standard finite, discrete, and discontinuous displacement element physics solvers for resolving Darcy fluid flow, explicit mechanics, implicit mechanics, and fluid-mediated fracturing, including resolution of physical behaviors both implicitly and explicitly, and (ii) a MPI-based parallelization implementation for use on generic HPC distributed memory architectures. The resultant code can be used alone for linearly elastic and quasistatic damage problems; problems involving hydraulic fracturing, where the mesh topology is dynamically changed; and general granular materials behavior. The key application domain is for low-rate stimulation and fracture control in subsurface reservoirs (e.g., enhanced geothermal sites and unconventional shale gas stimulation). GEOS-CORE also has interfaces to call external libraries for, e.g., material models and equations fo state; however, LLNL-developed EOS and material models, beyond the aforementioned linear elastic and quasi-static damage models, will not be part of the current release. GEOS-CORE's secondary applications include granular materials behavior under different load paths.

  1. GEOS-CORE

    2014-06-24

    GEOS-CORE is a code that integrates open source Libraries for linear algebra and I/O with two main LLNL-written components: (i) a set of standard finite, discrete, and discontinuous displacement element physics solvers for resolving Darcy fluid flow, explicit mechanics, implicit mechanics, and fluid-mediated fracturing, including resolution of physical behaviors both implicitly and explicitly, and (ii) a MPI-based parallelization implementation for use on generic HPC distributed memory architectures. The resultant code can be used alone formore » linearly elastic and quasistatic damage problems; problems involving hydraulic fracturing, where the mesh topology is dynamically changed; and general granular materials behavior. The key application domain is for low-rate stimulation and fracture control in subsurface reservoirs (e.g., enhanced geothermal sites and unconventional shale gas stimulation). GEOS-CORE also has interfaces to call external libraries for, e.g., material models and equations fo state; however, LLNL-developed EOS and material models, beyond the aforementioned linear elastic and quasi-static damage models, will not be part of the current release. GEOS-CORE's secondary applications include granular materials behavior under different load paths.« less

  2. Generic substitution, financial interests, and imperfect agency.

    PubMed

    Rischatsch, Maurus; Trottmann, Maria; Zweifel, Peter

    2013-06-01

    Policy makers around the world seek to encourage generic substitution. In this paper, the importance of prescribing physicians' imperfect agency is tested using the fact that some Swiss jurisdictions allow physicians to dispense drugs on their own account (physician dispensing, PD) while others disallow it. We estimate a model of physician drug choice with the help of drug claim data, finding a significant positive association between PD and the use of generics. While this points to imperfect agency, generics are prescribed more often to patients with high copayments or low incomes.

  3. A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS).

    PubMed

    Cherny, N I; Sullivan, R; Dafni, U; Kerst, J M; Sobrero, A; Zielinski, C; de Vries, E G E; Piccart, M J

    2015-08-01

    The value of any new therapeutic strategy or treatment is determined by the magnitude of its clinical benefit balanced against its cost. Evidence for clinical benefit from new treatment options is derived from clinical research, in particular phase III randomised trials, which generate unbiased data regarding the efficacy, benefit and safety of new therapeutic approaches. To date, there is no standard tool for grading the magnitude of clinical benefit of cancer therapies, which may range from trivial (median progression-free survival advantage of only a few weeks) to substantial (improved long-term survival). Indeed, in the absence of a standardised approach for grading the magnitude of clinical benefit, conclusions and recommendations derived from studies are often hotly disputed and very modest incremental advances have often been presented, discussed and promoted as major advances or 'breakthroughs'. Recognising the importance of presenting clear and unbiased statements regarding the magnitude of the clinical benefit from new therapeutic approaches derived from high-quality clinical trials, the European Society for Medical Oncology (ESMO) has developed a validated and reproducible tool to assess the magnitude of clinical benefit for cancer medicines, the ESMO Magnitude of Clinical Benefit Scale (ESMO-MCBS). This tool uses a rational, structured and consistent approach to derive a relative ranking of the magnitude of clinically meaningful benefit that can be expected from a new anti-cancer treatment. The ESMO-MCBS is an important first step to the critical public policy issue of value in cancer care, helping to frame the appropriate use of limited public and personal resources to deliver cost-effective and affordable cancer care. The ESMO-MCBS will be a dynamic tool and its criteria will be revised on a regular basis. PMID:26026162

  4. Generic substitution: issues for problematic drugs.

    PubMed

    Henderson, J D; Esham, R H

    2001-01-01

    The methodology and criteria for bioequivalence testing have been firmly established by the Food and Drug Administration (FDA). For certain drugs with a narrow therapeutic index (e.g., digoxin, levothyroxine, warfarin), generic substitution may not be advisable or even allowable, depending on the substitution laws of individual states. Digoxin and levothyroxine tablets are examples of drugs for which no New Drug Applications (NDAs) currently exist. However, commercially available generic products for both of these drugs have not been determined by the FDA to be therapeutically equivalent to the innovator products. Generic versions of warfarin have been approved by the FDA as being therapeutically equivalent to the innovator products, as have generic versions of the rescue inhaler albuterol. Yet, misinformation and myths persist regarding the adequacy and proven reliability of the FDA's determination of bioequivalence for these products.

  5. Genericness of a big bounce in isotropic loop quantum cosmology.

    PubMed

    Date, Ghanashyam; Hossain, Golam Mortuza

    2005-01-14

    The absence of isotropic singularity in loop quantum cosmology can be understood in an effective classical description as the Universe exhibiting a big bounce. We show that with a scalar matter field, the big bounce is generic in the sense that it is independent of quantization ambiguities and the details of scalar field dynamics. The volume of the Universe at the bounce point is parametrized by a single parameter. It provides a minimum length scale which serves as a cutoff for computations of density perturbations thereby influencing their amplitudes. PMID:15698060

  6. Structure of the jet from a generic catheter tip

    NASA Astrophysics Data System (ADS)

    Foust, J.; Rockwell, D.

    2006-10-01

    A generic feature of a wide variety of central venous catheters, which are typically located within the superior vena cava (SVC), is a jet from a side hole of the catheter tip. Particle image velocimetry is employed in conjunction with a scaled-up water facility, in order to characterize the structure of the jet as a function of dimensionless hole diameter and jet velocity ratio. Quantitative patterns in the radial and crossflow planes of the catheter-SVC system define the jet evolution. It has distinctive features, relative to the classical jet in a crossflow, which issues from a small opening in a planar surface into a region of large extent.

  7. Generic hypersonic vehicle performance model

    NASA Technical Reports Server (NTRS)

    Chavez, Frank R.; Schmidt, David K.

    1993-01-01

    An integrated computational model of a generic hypersonic vehicle was developed for the purpose of determining the vehicle's performance characteristics, which include the lift, drag, thrust, and moment acting on the vehicle at specified altitude, flight condition, and vehicular configuration. The lift, drag, thrust, and moment are developed for the body fixed coordinate system. These forces and moments arise from both aerodynamic and propulsive sources. SCRAMjet engine performance characteristics, such as fuel flow rate, can also be determined. The vehicle is assumed to be a lifting body with a single aerodynamic control surface. The body shape and control surface location are arbitrary and must be defined. The aerodynamics are calculated using either 2-dimensional Newtonian or modified Newtonian theory and approximate high-Mach-number Prandtl-Meyer expansion theory. Skin-friction drag was also accounted for. The skin-friction drag coefficient is a function of the freestream Mach number. The data for the skin-friction drag coefficient values were taken from NASA Technical Memorandum 102610. The modeling of the vehicle's SCRAMjet engine is based on quasi 1-dimensional gas dynamics for the engine diffuser, nozzle, and the combustor with heat addition. The engine has three variable inputs for control: the engine inlet diffuser area ratio, the total temperature rise through the combustor due to combustion of the fuel, and the engine internal expansion nozzle area ratio. The pressure distribution over the vehicle's lower aft body surface, which acts as an external nozzle, is calculated using a combination of quasi 1-dimensional gas dynamic theory and Newtonian or modified Newtonian theory. The exhaust plume shape is determined by matching the pressure inside the plume, calculated from the gas dynamic equations, with the freestream pressure, calculated from Newtonian or Modified Newtonian theory. In this manner, the pressure distribution along the vehicle after body

  8. Enacting Common Core Instruction: How Intermediate Unit 13 Leveraged Its Position as an Educational Service Agency to Implement and Scale the LDC Initiative

    ERIC Educational Resources Information Center

    Research For Action, 2014

    2014-01-01

    Funded by The Bill & Melinda Gates Foundation, the Literacy Design Collaborative (LDC) and Math Design Collaborative (MDC) offer a set of instructional and formative assessment tools in literacy and math, which were developed to help educators better prepare all students to meet the Common Core State Standards (CCSS) and succeed beyond high…

  9. Supersaturation-controlled surface structure evolution of Pd@Pt core-shell nanocrystals: enhancement of the ORR activity at a sub-10 nm scale

    NASA Astrophysics Data System (ADS)

    Qi, Kun; Zheng, Weitao; Cui, Xiaoqiang

    2016-01-01

    Here, we designed and implemented a facile strategy for controlling the surface evolution of Pd@Pt core-shell nanostructures by simply adjusting the volume of OH- to control the reducing ability of ascorbic acid and finally manipulating the supersaturation in the reaction system. The surface structure of the obtained Pd@Pt bimetallic nanocrystals transformed from a Pt {111} facet-exposed island shell to a conformal Pt {100} facet-exposed shell by increasing the pH value. The as-prepared well aligned Pd@Pt core-island shell nanocubes present both significantly enhanced electrocatalytic activity and favorable long-term stability toward the oxygen reduction reaction in alkaline media.Here, we designed and implemented a facile strategy for controlling the surface evolution of Pd@Pt core-shell nanostructures by simply adjusting the volume of OH- to control the reducing ability of ascorbic acid and finally manipulating the supersaturation in the reaction system. The surface structure of the obtained Pd@Pt bimetallic nanocrystals transformed from a Pt {111} facet-exposed island shell to a conformal Pt {100} facet-exposed shell by increasing the pH value. The as-prepared well aligned Pd@Pt core-island shell nanocubes present both significantly enhanced electrocatalytic activity and favorable long-term stability toward the oxygen reduction reaction in alkaline media. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr07940c

  10. 42 CFR 447.506 - Authorized generic drugs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Authorized generic drugs. 447.506 Section 447.506... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment for Drugs § 447.506 Authorized generic drugs. (a) Authorized generic drug defined. For the purposes of this subpart, an authorized generic...

  11. 42 CFR 447.506 - Authorized generic drugs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Authorized generic drugs. 447.506 Section 447.506... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment for Drugs § 447.506 Authorized generic drugs. (a) Authorized generic drug defined. For the purposes of this subpart, an authorized generic...

  12. 42 CFR 447.506 - Authorized generic drugs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Authorized generic drugs. 447.506 Section 447.506... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment for Drugs § 447.506 Authorized generic drugs. (a) Authorized generic drug defined. For the purposes of this subpart, an authorized generic...

  13. 42 CFR 447.506 - Authorized generic drugs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Authorized generic drugs. 447.506 Section 447.506... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment for Drugs § 447.506 Authorized generic drugs. (a) Authorized generic drug defined. For the purposes of this subpart, an authorized generic...

  14. 42 CFR 447.506 - Authorized generic drugs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Authorized generic drugs. 447.506 Section 447.506... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS PAYMENTS FOR SERVICES Payment for Drugs § 447.506 Authorized generic drugs. (a) Authorized generic drug defined. For the purposes of this subpart, an authorized generic...

  15. Application of Core Dynamics Modeling to Core-Mantle Interactions

    NASA Technical Reports Server (NTRS)

    Kuang, Weijia

    2003-01-01

    Observations have demonstrated that length of day (LOD) variation on decadal time scales results from exchange of axial angular momentum between the solid mantle and the core. There are in general four core-mantle interaction mechanisms that couple the core and the mantle. Of which, three have been suggested likely the dominant coupling mechanism for the decadal core-mantle angular momentum exchange, namely, gravitational core-mantle coupling arising from density anomalies in the mantle and in the core (including the inner core), the electromagnetic coupling arising from Lorentz force in the electrically conducting lower mantle (e.g. D-layer), and the topographic coupling arising from non-hydrostatic pressure acting on the core-mantle boundary (CMB) topography. In the past decades, most effort has been on estimating the coupling torques from surface geomagnetic observations (kinematic approach), which has provided insights on the core dynamical processes. In the meantime, it also creates questions and concerns on approximations in the studies that may invalidate the corresponding conclusions. The most serious problem is perhaps the approximations that are inconsistent with dynamical processes in the core, such as inconsistencies between the core surface flow beneath the CMB and the CMB topography, and that between the D-layer electric conductivity and the approximations on toroidal field at the CMB. These inconsistencies can only be addressed with numerical core dynamics modeling. In the past few years, we applied our MoSST (Modular, Scalable, Self-consistent and Three-dimensional) core dynamics model to study core-mantle interactions together with geodynamo simulation, aiming at assessing the effect of the dynamical inconsistencies in the kinematic studies on core-mantle coupling torques. We focus on topographic and electromagnetic core-mantle couplings and find that, for the topographic coupling, the consistency between the core flow and the CMB topography is

  16. Generic medicines: issues and relevance for global health.

    PubMed

    Rana, Proteesh; Roy, Vandana

    2015-12-01

    Generic medicine is a pharmaceutical product which is bioequivalent to the innovator product in terms of dosage form, strength, route of administration, quality, safety, performance characteristics, and intended use. Generic medicines are a cornerstone for providing affordable medicines to patients. The major generic markets in the world include United States of America followed by European Union, Canada, Japan, and Australia. The major suppliers of generic medicines China and India are showing tremendous growth in the generic medicine sector. There are many legal and regulatory issues along with quality concerns associated with the use of the generic products. Lately, bilateral international agreements called free trade agreements, delaying tactics by originator companies like strategic patenting and litigations on generic manufacturers, have been a major setback for the generic medicine industry. These issues need to be addressed to optimize the use of generic medicines. The sustainability of generic medicine sector is crucial for improving access to essential medicines for the worldwide. PMID:26405851

  17. Understanding and perceptions of final-year Doctor of Pharmacy students about generic medicines in Karachi, Pakistan: a quantitative insight

    PubMed Central

    Jamshed, Shazia Qasim; Ibrahim, Mohamad Izham Mohamad; Hassali, Mohamad Azmi; Sharrad, Adheed Khalid; Shafie, Asrul Akmal; Babar, Zaheer-Ud-Din

    2015-01-01

    General objective To evaluate the understanding and perceptions of generic medicines among final-year Doctor of Pharmacy students in Karachi, Pakistan. Methods A 23-item survey instrument that included a question on the bioequivalence limits and Likert-type scale questions regarding the understanding and perceptions of generic medicines among the students was executed. Cronbach’s alpha was found to be 0.62. Results Responses were obtained from 236 final-year Doctor of Pharmacy students (n=85 from a publicly funded institute; n=151 from a privately funded institute). When comparing a brand-name medicine to a generic medicine, pharmacy students scored poorly on bioequivalence limits. More than 80% of the students incorrectly answered that all the products that are rated as generic equivalents are therapeutically equivalent to each other (P<0.04). Half of the students agreed that a generic medicine is bioequivalent to the brand-name medicine (P<0.001). With regard to quality, effectiveness, and safety, more than 75% of the students disagreed that generic medicines are of inferior quality and are less effective than brand-name medicines (P<0.001). More than 50% of the students disagreed that generic medicines produce more side effects than brand-name medicines (P<0.001). Conclusion The current study identified a positive perception toward generic medicines but also gaps in the understanding of generic medicines. Pharmacy students lacked a thorough understanding of the concepts of bioequivalence. Pharmacy academia should address these issues, which will help build confidence in generic medicines and increase the generic medicine use in Pakistan. PMID:26028981

  18. Effects of generic versus non-generic feedback on motor learning in children.

    PubMed

    Chiviacowsky, Suzete; Drews, Ricardo

    2014-01-01

    Non-generic feedback refers to a specific event and implies that performance is malleable, while generic feedback implies that task performance reflects an inherent ability. The present study examined the influences of generic versus non-generic feedback on motor performance and learning in 10-year-old children. In the first experiment, using soccer ball kicking at a target as a task, providing participants with generic feedback resulted in worse performance than providing non-generic feedback, after both groups received negative feedback. The second experiment measured more permanent effects. Results of a retention test, performed one day after practicing a throwing task, showed that participants who received non-generic feedback during practice outperformed the generic feedback group, after receiving a negative feedback statement. The findings demonstrate the importance of the wording of feedback. Even though different positive feedback statements may not have an immediate influence on performance, they can affect performance, and presumably individuals' motivation, when performance is (purportedly) poor. Feedback implying that performance is malleable, rather than due to an inherent ability, seems to have the potential to inoculate learners against setbacks--a situation frequently encountered in the context of motor performance and learning.

  19. 77 FR 30560 - Proposed Generic Communication; Generic Letter on Seismic Risk Evaluations for Operating Reactors

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ... Operating Reactors'' published on September 1, 2011 (76 FR 54507). The draft Generic Letter, ``Seismic Risk...: On September 1, 2011 (76 FR 54507), the NRC published for public comment Draft Generic Letter 2011-XX..., 2011 (76 FR 57767), the NRC issued a correction and extended the public comment period to November...

  20. A Generic Expert Scheduling System Architecture and Toolkit: GUESS (Generically Used Expert Scheduling System)

    NASA Technical Reports Server (NTRS)

    Liebowitz, Jay; Krishnamurthy, Vijaya; Rodens, Ira; Houston, Chapman; Liebowitz, Alisa; Baek, Seung; Radko, Joe; Zeide, Janet

    1996-01-01

    Scheduling has become an increasingly important element in today's society and workplace. Within the NASA environment, scheduling is one of the most frequently performed and challenging functions. Towards meeting NASA's scheduling needs, a research version of a generic expert scheduling system architecture and toolkit has been developed. This final report describes the development and testing of GUESS (Generically Used Expert Scheduling System).

  1. 76 FR 57767 - Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-16

    ... appearing in the Federal Register on September 1, 2011 (76 FR 54507), that requested public comment on Draft... Register document 2011-22422, published September 1, 2011 (76 FR 54507), in the second column, under the... COMMISSION Proposed Generic Communication; Draft NRC Generic Letter 2011-XX: Seismic Risk Evaluations...

  2. Generic ad Extendable Reliability Prediction Methodology for Complex Critical Systems

    NASA Astrophysics Data System (ADS)

    Silva, N.; Lopes, R.; Esper, A.; Barbosa, R.

    2013-08-01

    Reliability Analysis is currently performed for a variety of domains, such as aeronautics, space and railway, generally included in a larger set of RAMS analysis. Even though the reliability standards adopted for each of those domains are different, the core techniques and skills applied in the reliability analysis process is in essence the same. Considering this fact, the reliability analysis process can be generalised in such a way that it can be applied transversely across several domains with the appropriate level of tailoring. This work presents the Generic Reliability Analysis Process (GRAP), which can in practice be instantiated to a wide variety of domains, with a reduced level of tailoring required in each case. It also presents a comparison between the input standards applied in the aeronautics, space and railway domains, as well as some key parameters to perform an initial estimation of the effort required to perform such analysis.

  3. Flow Separation in Undisturbed Soil Using Multiple Anionic Tracers. Part 2. Steady-State Core-Scale Rainfall and Return Flows and Determination of Dispersion Parameters

    NASA Astrophysics Data System (ADS)

    Henderson, D. E.; Reeves, A. D.; Beven, K. J.; Chappell, N. A.

    1996-11-01

    A series of experiments designed to study the separation of flow components from two large undisturbed cores under steady-state rainfall (downward) and return (upward) flows under near-saturated conditions is summarized. The experiments were conducted on soil columns collected from Lancaster University and the Slapton Wood catchment, Devon. The use of the relatively conservative tracers, potassium bromide, o-(trifluoromethyl)benzoic acid and 2,6-difluorobenzoic acid and a combination of application rates made it possible to quantify the different sources of water contributing to the discharge hydrographs. There is significant retention of tracer within the cores, despite the application of several pore volumes of water. The use of steady flow conditions allowed the determination of dispersion coefficients, dispersivity and proportion of mobile water content parameters of the advection-dispersion equation. It was found that there were significant differences between the dispersivities at different flow-rates under upward and downward flux conditions and that in the undisturbed cores studied here the apparent proportions of mobile pore water ranged between 0.33 and 1.0, with an apparently complex relationship to flux rate. Prediction of transport in undisturbed soil remains problematic and tracer experiments will continue to be needed to provide a fundamental understanding of the complex flow processes involved.

  4. Gas hydrate characterization and grain-scale imaging of recovered cores from the Mount Elbert Gas Hydrate Stratigraphic Test Well, Alaska North Slope

    USGS Publications Warehouse

    Stern, L.A.; Lorenson, T.D.; Pinkston, J.C.

    2011-01-01

    Using cryogenic scanning electron microscopy (CSEM), powder X-ray diffraction, and gas chromatography methods, we investigated the physical states, grain characteristics, gas composition, and methane isotopic composition of two gas-hydrate-bearing sections of core recovered from the BPXA-DOE-USGS Mount Elbert Gas Hydrate Stratigraphic Test Well situated on the Alaska North Slope. The well was continuously cored from 606.5. m to 760.1. m depth, and sections investigated here were retrieved from 619.9. m and 661.0. m depth. X-ray analysis and imaging of the sediment phase in both sections shows it consists of a predominantly fine-grained and well-sorted quartz sand with lesser amounts of feldspar, muscovite, and minor clays. Cryogenic SEM shows the gas-hydrate phase forming primarily as a pore-filling material between the sediment grains at approximately 70-75% saturation, and more sporadically as thin veins typically several tens of microns in diameter. Pore throat diameters vary, but commonly range 20-120 microns. Gas chromatography analyses of the hydrate-forming gas show that it is comprised of mainly methane (>99.9%), indicating that the gas hydrate is structure I. Here we report on the distribution and articulation of the gas-hydrate phase within the cores, the grain morphology of the hydrate, the composition of the sediment host, and the composition of the hydrate-forming gas. ?? 2009.

  5. Gas hydrate characterization and grain-scale imaging of recovered cores from the Mount Elbert Gas Hydrate Stratigraphic Test Well, Alaska North Slope

    USGS Publications Warehouse

    Stern, Laura A.; Lorenson, T.D.; Pinkston, John C.

    2011-01-01

    Using cryogenic scanning electron microscopy (CSEM), powder X-ray diffraction, and gas chromatography methods, we investigated the physical states, grain characteristics, gas composition, and methane isotopic composition of two gas-hydrate-bearing sections of core recovered from the BPXA–DOE–USGS Mount Elbert Gas Hydrate Stratigraphic Test Well situated on the Alaska North Slope. The well was continuously cored from 606.5 m to 760.1 m depth, and sections investigated here were retrieved from 619.9 m and 661.0 m depth. X-ray analysis and imaging of the sediment phase in both sections shows it consists of a predominantly fine-grained and well-sorted quartz sand with lesser amounts of feldspar, muscovite, and minor clays. Cryogenic SEM shows the gas-hydrate phase forming primarily as a pore-filling material between the sediment grains at approximately 70–75% saturation, and more sporadically as thin veins typically several tens of microns in diameter. Pore throat diameters vary, but commonly range 20–120 microns. Gas chromatography analyses of the hydrate-forming gas show that it is comprised of mainly methane (>99.9%), indicating that the gas hydrate is structure I. Here we report on the distribution and articulation of the gas-hydrate phase within the cores, the grain morphology of the hydrate, the composition of the sediment host, and the composition of the hydrate-forming gas.

  6. GOoDA: The Generic Optimization Data Analyzer

    NASA Astrophysics Data System (ADS)

    Calafiura, P.; Eranian, S.; Levinthal, D.; Kama, S.; Vitillo, R. A.

    2012-12-01

    Modern superscalar, out-of-order microprocessors dominate large scale server computing. Monitoring their activity, during program execution, has become complicated due to the complexity of the microarchitectures and their IO interactions. Recent processors have thousands of performance monitoring events. These are required to actually provide coverage for all of the complex interactions and performance issues that can occur. Knowing which data to collect and how to interpret the results has become an unreasonable burden for code developers whose tasks are already hard enough. It becomes the task of the analysis tool developer to bridge this gap. To address this issue, a generic decomposition of how a microprocessor is using the consumed cycles allows code developers to quickly understand which of the myriad of microarchitectural complexities they are battling, without requiring a detailed knowledge of the microarchitecture. When this approach is intrinsically integrated into a performance data analysis tool, it enables software developers to take advantage of the microarchitectural methodology that has only been available to experts. The Generic Optimization Data Analyzer (GOoDA) project integrates this expertise into a profiling tool in order to lower the required expertise of the user and, being designed from the ground up with large-scale object-oriented applications in mind, it will be particularly useful for large HENP codebases

  7. Generic Rigidity for Circle Diffeomorphisms with Breaks

    NASA Astrophysics Data System (ADS)

    Kocić, Saša

    2016-06-01

    We prove that {C^r}-smooth ({r > 2}) circle diffeomorphisms with a break, i.e., circle diffeomorphisms with a single singular point where the derivative has a jump discontinuity, are generically, i.e., for almost all irrational rotation numbers, not {C^{1+\\varepsilon}}-rigid, for any {\\varepsilon > 0}. This result complements our recent proof, joint with Khanin (Geom Funct Anal 24:2002-2028, 2014), that such maps are generically {C^1}-rigid. It stands in remarkable contrast to the result of Yoccoz (Ann Sci Ec Norm Sup 17:333-361, 1984) that {C^r}-smooth circle diffeomorphisms are generically {C^{r-1-κ}}-rigid, for any {κ > 0}.

  8. Generic language facilitates children's cross-classification

    PubMed Central

    Nguyen, Simone P.; Gelman, Susan A.

    2012-01-01

    Four studies examined the role of generic language in facilitating 4- and 5-year-old children's ability to cross-classify. Participants were asked to classify an item into a familiar (taxonomic or script) category, then cross-classify it into a novel (script or taxonomic) category with the help of a clue expressed in either generic or specific language. Experiment 1 showed that generics facilitate 5-year-olds' and adults' cross-classification when expressed at an appropriate level of generalization (e.g., “foods,” “birthday party things”), whereas Experiment 2 showed that such effects disappeared when labels were at an inappropriate level of generalization (e.g., “pizzas,” “balloons”). Experiments 3 and 4 offered additional controls. Taken together, the findings demonstrate that language can guide and direct children's multiple categorizations. PMID:22888182

  9. Mixed WTO ruling on generic drug development.

    PubMed

    Elliott, R

    2000-01-01

    On 17 March 2000, the World Trade Organization upheld the provision in Canada's patent laws that allows generic drug manufacturers to develop (but not sell) their cheaper versions of patented medicines before the 20-year patients expire. The decision prevents pharmaceutical companies from enjoying market monopolies beyond their patent terms, avoiding what would otherwise be even lengthier delays in the sale of cheaper, generic drugs in Canada. This decision is of significance not only to Canada, but also to other WTO member countries and to all individuals who use pharmaceutical products. However, the decision is not all positive: the WTO also ruled that Canada is violating international agreements by letting generic manufacturers stockpile their versions of patented drugs before patents expire. This article explains the issues, the arguments, and the decision.

  10. 24. A CORE WORKER DISPLAYS THE CORE BOX AND CORES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. A CORE WORKER DISPLAYS THE CORE BOX AND CORES FOR A BRASS GATE VALVE BODY MADE ON A CORE BOX, CA. 1950. - Stockham Pipe & Fittings Company, 4000 Tenth Avenue North, Birmingham, Jefferson County, AL

  11. Quantum teleportation of a generic two-photon state with weak cross-Kerr nonlinearities

    NASA Astrophysics Data System (ADS)

    Wang, Meiyu; Yan, Fengli

    2016-08-01

    We present a scheme for teleporting a generic two-photon polarization state by using two EPR states as quantum channel based on weak cross-Kerr nonlinearities. As the core component of the present framework, the quantum nondemolition detector based on the weak cross-Kerr nonlinearity acts as an EPR entangler as well as the Bell-state analyzer. This makes the teleportation protocol be achieved near deterministically and be feasible in the current experimental technology.

  12. Generic health/safety/environment cases

    SciTech Connect

    Kelland, A.N.; Primrose, M.; Pickles, J.C.

    1996-12-31

    A desire to implement HSE Management Systems including HSE Cases in all Shell companies operations prompted the development of a relational data base software package (THESIS) to provide a structured way of preparing an HSE Case. The software includes features which facilitate the management of {open_quotes}Keeping the Case Alive{close_quotes}, enabling the dissemination of tasks and hazard information to the workplace. During the software development it was recognized that a significant reduction could be made in the resources which would be required to prepare an HSE Case for each and every operation by the building of {open_quotes}Generic HSE Cases{close_quotes} addressing specific activities which were repeated across the Company`s operations. This was recognized to be particularly valid for the smaller Single String Venture type of operations. The activities selected for the initial Generic HSE Case development include Land Drilling Operations, Land Seismic Acquisition, and Land Transport. To establish the Generic HSE Case, the THESIS data base is populated with data for a generic operation, identifying all the hazards and activities associated with that operation including all the associated controls, with established formats for the textual sections. In effect, the Generic Case defines the standards required for that type of operation. To generate an operation specific HSE Case, the Generic Case thereafter requires to be modified/adapted so that it represents the actual situation in the operation which it defines. This process includes itemization of all the operation specific details, and may involve the inclusion/deletion of any additional/existing activities or hazards together with their associated controls.

  13. Benefits of Digital Equipment Generic Qualification Activities

    SciTech Connect

    Thomas, James E.; Steiman, Samuel C.

    2002-07-01

    As a result of nuclear power plant instrumentation and control obsolescence issues, there have been numerous activities during recent years relating to the qualification of digital equipment. Some of these activities have been 'generic' in nature in that the qualification was not limited to plant specific applications, but was intended to cover a broad base of potential applications of the digital equipment. These generic qualifications have been funded by equipment manufacturers and by utility groups and organizations. The generic activities sponsored by the Electric Power Research Institute (EPRI) have been pilot projects for an overall generic qualification approach. The primary benefit resulting from the generic qualification work to date is that a number of digital platforms and digital devices are now available for use in various nuclear safety-related applications. Many of the tests and evaluations necessary to support plant specific applications have been completed. The amount of data and documentation that each utility must develop on a case by case basis has been significantly reduced. There are also a number of additional benefits resulting from these industry efforts. The challenges and difficulties in qualifying digital equipment for safety-related applications are now more clearly understood. EPRI has published a lessons learned document (EPRI Report 1001452, Generic Qualification of Commercial Grade Digital Devices: Lessons Learned from Initial Pilots, which covers several different qualification areas, including device selection, project planning, vendor surveys and design reviews, and electromagnetic compatibility (EMC) qualification. Application of the experience and lessons learned from the EPRI pilot activities should help reduce the effort and cost required for future qualification work. Most generic qualification activities for commercial equipment have been conducted using the approach of EPRI TR-106439, Guideline on Evaluation and Acceptance

  14. The formal verification of generic interpreters

    NASA Technical Reports Server (NTRS)

    Windley, P.; Levitt, K.; Cohen, G. C.

    1991-01-01

    The task assignment 3 of the design and validation of digital flight control systems suitable for fly-by-wire applications is studied. Task 3 is associated with formal verification of embedded systems. In particular, results are presented that provide a methodological approach to microprocessor verification. A hierarchical decomposition strategy for specifying microprocessors is also presented. A theory of generic interpreters is presented that can be used to model microprocessor behavior. The generic interpreter theory abstracts away the details of instruction functionality, leaving a general model of what an interpreter does.

  15. 75 FR 16737 - Proposed Information Collection; Comment Request; Generic Clearance for Questionnaire Pretesting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... Questionnaire Pretesting Research AGENCY: U.S. Census Bureau. ACTION: Notice. SUMMARY: The Department of...-scale questionnaire pretesting activities under this generic clearance. A block of hours will be... will be used by the Census Bureau and survey sponsors to improve questionnaires and procedures,...

  16. 78 FR 23743 - Proposed Information Collection; Comment Request; Generic Clearance for Questionnaire Pretesting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... Questionnaire Pretesting Research AGENCY: Census Bureau, Commerce. ACTION: Notice. SUMMARY: The Department of... of small-scale questionnaire pretesting activities under this generic clearance. A block of hours... research program will be used by the Census Bureau and survey sponsors to improve questionnaires...

  17. Genericness of inflation in isotropic loop quantum cosmology.

    PubMed

    Date, Ghanashyam; Hossain, Golam Mortuza

    2005-01-14

    Nonperturbative corrections from loop quantum cosmology (LQC) to the scalar matter sector are already known to imply inflation. We prove that the LQC modified scalar field generates exponential inflation in the small scale factor regime, for all positive definite potentials, independent of initial conditions and independent of ambiguity parameters. For positive semidefinite potentials it is always possible to choose, without fine-tuning, a value of one of the ambiguity parameters such that exponential inflation results, provided zeros of the potential are approached at most as a power law in the scale factor. In conjunction with the generic occurrence of bounce at small volumes, particle horizon is absent, thus eliminating the horizon problem of the standard big bang model. PMID:15698059

  18. GENERIC MODEL FOR MAGNETIC EXPLOSIONS APPLIED TO SOLAR FLARES

    SciTech Connect

    Melrose, D. B.

    2012-04-10

    An accepted model for magnetospheric substorms is proposed as the basis for a generic model for magnetic explosions and is applied to solar flares. The model involves widely separated energy-release and particle-acceleration regions, with energy transported Alfvenically between them. On a global scale, these regions are coupled by a large-scale current that is set up during the explosion by redirection of pre-existing current associated with the stored magnetic energy. The explosion-related current is driven by an electromotive force (EMF) due to the changing magnetic flux enclosed by this current. The current path and the EMF are identified for an idealized quadrupolar model for a flare.

  19. Monitoring soil and vegetation fluxes of carbon and water at the global scale: the land carbon core information service of geoland2

    NASA Astrophysics Data System (ADS)

    Calvet, J.-C.; Balsamo, G.; Chevallier, F.; Kullmann, L.; Papale, D.; Seufert, G.; The, H.; Gibelin, A.-L.; Horanyi, A.; Lafont, S.

    2009-04-01

    The vegetation/land component of GMES is called "Land Monitoring Core service" (LMCS). The geoland2 European project (FP7, 2008-2012) is a demonstrator of the evolution of the LMCS, including the consolidation of prototype services and the test of their operational capacity. In particular, the perimeter of the LMCS is extended, with a global component (biogeophysical parameters), and thematic core information services. The main mission of the land carbon core information service (LC-CIS) of geoland2 is to assess the impact of weather and climate variability on terrestrial biospheric carbon fluxes, in the context of international conventions. The LC-CIS aims at monitoring the global terrestrial carbon fluxes (e.g. to support reporting obligations in the course of the Kyoto Protocol) and setting-up pre-operational infrastructures for providing global products, both in near real time and off-line mode. A multi-model carbon accounting system is developed, coupled with EO data assimilation schemes. Emphasis is put on validation (in-situ data), with downscaling on reference European countries (F, NL, HU). The C-TESSEL and SURFEX modelling platforms (of ECMWF and Météo-France, respectively) are used for production. The ORCHIDEE modelling platform (LSCE) is used for benchmarking and validation purposes. The ECWMF reanalysis (ERA-Interim) will be used to build a global 20-y climatology of carbon and water fluxes, LAI and vegetation biomass, in order to rank the near-real time simulations. Gradually, EO data will be integrated in the modelling platforms, in order to improve the atmospheric constraint on the model (e.g. downwelling solar radiation from the EUMETSAT's Land-SAF), analyse soil moisture and vegetation biomass (e.g. assimilate the EUMETSAT's ASCAT soil moisture product and MODIS and/or SPOT/VGT LAI estimates). Finally, EO data will be used for model verification (e.g. land surface temperature).

  20. Possibility of Exciton Mediated Superconductivity in Nano-Sized Sn/Si Core-Shell Clusters: A Process Technology towards Heterogeneous Material in Nano-Scale

    NASA Astrophysics Data System (ADS)

    Kurokawa, Yuichiro; Hihara, Takehiko; Ichinose, Ikuo; Sumiyama, Kenji

    2012-07-01

    We have produced Sn/Si core-shell cluster assemblies by a plasma-gas-condensation cluster beam deposition apparatus. For the sample with Si content = 12 at. %, the temperature dependence of electrical resistivity exhibits a metallic behavior above 10 K and the onset of superconducting transition below 6.1 K. With decreasing temperature, the thermomagnetic curve for the sample with Si content = 8 at. % begins to decrease steadily toward negative value below 7.7 K, indicating the Meissner effect. An increase in the transition temperature, TC is attributable to exciton-type superconductivity.

  1. The effect of molecular weight on the adsorption/desorption characteristics of polymeric scale inhibitors on silica sand and in sandstone cores

    SciTech Connect

    Graham, G.M.; Sorbie, K.S.

    1994-12-31

    A number of polymeric scale inhibitors are currently used for downhole application in oilfield ``squeeze`` treatments. These materials must perform the dual role of inhibiting scale formation at low concentration levels whilst giving acceptably long return curves at the wellbore. Both of these design aspects of polymeric scale inhibitors relate to their adsorption characteristics (either on the growing scale crystal or onto the rock substrate) which, in turn, are functions of the molecular weight of the species. In this paper, the authors examine the effects of inhibitor molecular weight on its adsorption characteristics onto highly quartzitic substrates and they discuss the importance of this factor in governing the dynamics of the inhibitor return curve. The effects of molecular weight on the inhibition efficiency, during both early nucleation and later crystal growth, are also examined. The adsorption/desorption characteristics of three polymeric scale inhibitors, each having a range of molecular weights, are studied in this work: viz. polyacrylate (PAA) and phosphinopolycarboxylate (PPCA) scale inhibitors of weight average molecular weight, M{sub w} < 10,000 g/mol, and polyvinyl sulphonic acid (PVS) inhibitors of M{sub w} < 20,000 g/mol. Using these polymers, the authors show that the preferential adsorption of the higher molecular weight components occurs. Results on the scale inhibition efficiency of barium sulphate, obtained for the same range of polymeric inhibitors, are also presented as functions of molecular weight. The factors required to ensure a long return curve are not necessarily the same as those for efficient inhibition under certain solution conditions (e.g. solution pH). This illustrates the importance of reaching a compromise in terms of molecular weight between inhibition efficiency and squeeze lifetime. The significance of these findings for field squeeze treatments using polymeric inhibitors is discussed. 43 refs.

  2. The large-scale plasmaspheric density trough associated with the 24 May 2000 geomagnetic storm: IMAGE EUV observations and global core plasma modeling

    NASA Astrophysics Data System (ADS)

    Adrian, M. L.; Gallagher, D. L.; Green, J. L.; Sandel, B. R.

    2001-05-01

    The IMAGE EUV imager observed a plasmaspheric density trough in association with a geomagnetically active period on 24 May 2000. In EUV, this density trough appears as an Archimedes spiral extending from Earth's shadow to approximately 1800 MLT. We present an analysis of this density trough using simulated EUV images. Observational EUV images are subjected to edge analysis to establish the plasmapause L-shell and the location of the density trough in terms of L-shell, MLT extent, and radial width. The plasmaspheric density distribution is modeled using both static and dynamic models for the plasmasphere. The background plasmasphere is then numerically simulated using the 4-parameter plasmaspheric density model contained within the Global Core Plasma Model (GCPM) [Gallagher et al., 2000] and the Dynamic Global Core Plasma Model (DGCPM) [Ober et al., 1997]. Simulated EUV images of the model plasmasphere are produced once an artificial density depletion, matching the observed MLT extent and width, has been removed. Once the azimuthal extent and width of the trough have been simulated, the depth of the artificial density depletion is iteratively adjusted to produce simulated EUV images that approximate observation. The results of this analysis and discussion of possible origins for this density trough will be presented.

  3. The Large-Scale Plasmaspheric Density Trough Associated With the 24 May 2000 Geomagnetic Storm: IMAGE EUV Observations and Global Core Plasma Modeling

    NASA Technical Reports Server (NTRS)

    Adrian, M. L.; Gallagher, D. L.; Green, J. L.; Sandel, B. R.; Rose, M. Franklin (Technical Monitor)

    2001-01-01

    The IMAGE EUV imager observed a plasmaspheric density, trough in association with a geomagnetically active period on 24 May 2000. In EUV, this density, trough appears as an Archimedes spiral extending from Earth's shadow to approximately 1900 MLT. We present an analysis of this density trough using simulated EUV images, Observational EUV images are subjected to edge analysis to establish the plasmapause L-shell and the location of the density trough in terms of L-shell, MLT extent, and radial width. The plasmaspheric density distribution is modeled using both static and dynamic models for the plasmasphere. The background plasmasphere is then numerically simulated using the 4-parameter plasmaspheric density model contained within the Global Core Plasma Model (GCPM) and the Dynamic Global Core Plasma Model (DGCPM). Simulated EUV images of the model plasmasphere are produced once an artificial density, depletion, matching the observed MLT extent and width, has been removed. Once the azimuthal extent and width of the trough have been simulated, the depth of the artificial density depletion is iteratively adjusted to produce simulated EUV images that approximate observation. The results of this analysis and discussion of possible origins for this density trough will be presented.

  4. Acoustic Source Localization via Time Difference of Arrival Estimation for Distributed Sensor Networks using Tera-scale Optical-Core Devices

    SciTech Connect

    Imam, Neena; Barhen, Jacob

    2009-01-01

    For real-time acoustic source localization applications, one of the primary challenges is the considerable growth in computational complexity associated with the emergence of ever larger, active or passive, distributed sensor networks. These sensors rely heavily on battery-operated system components to achieve highly functional automation in signal and information processing. In order to keep communication requirements minimal, it is desirable to perform as much processing on the receiver platforms as possible. However, the complexity of the calculations needed to achieve accurate source localization increases dramatically with the size of sensor arrays, resulting in substantial growth of computational requirements that cannot be readily met with standard hardware. One option to meet this challenge builds upon the emergence of digital optical-core devices. The objective of this work was to explore the implementation of key building block algorithms used in underwater source localization on the optical-core digital processing platform recently introduced by Lenslet Inc. This demonstration of considerably faster signal processing capability should be of substantial significance to the design and innovation of future generations of distributed sensor networks.

  5. European Generic Medicines Association (EGA)--16th Annual Conference.

    PubMed

    Kennedy, Bob

    2010-08-01

    The 16th Annual Conference of the European Generic Medicines Association (EGA), held in Rome, included topics covering new developments and challenges in the generic medicines industry in Europe. This conference report highlights selected presentations on developments for generics in the Italian healthcare system, a summary of the EGA pharmaceutical sector inquiry on the delayed market entry of generics, developments and trends in the European generics market, the evolution and growth of the global generics industry, and a CEO perspective on the challenges facing the industry.

  6. The importance of being first: evidence from Canadian generic pharmaceuticals.

    PubMed

    Hollis, Aidan

    2002-12-01

    This paper uses pooled cross-section data on Canadian ethical drug sales to examine the effect of entry timing on sales of generic drugs. The data is for all drugs for which the first generic competitor entered during the years 1994-1997. It is found that the first generic entrant has a lasting competitive advantage: being first into the market appears to lead to an increase of around 30% in market share (among generics) over a period of at least 4 years. This finding has considerable implications for the current policy of allowing brandname drug companies to issue pseudo-generic equivalents as a preemptive strike against true generic competitors.

  7. 100,000-year-long terrestrial record of millennial-scale linkage between eastern North American mid-latitude paleovegetation shifts and Greenland ice-core oxygen isotope trends

    NASA Astrophysics Data System (ADS)

    Litwin, Ronald J.; Smoot, Joseph P.; Pavich, Milan J.; Markewich, Helaine W.; Brook, George; Durika, Nancy J.

    2013-09-01

    We document frequent, rapid, strong, millennial-scale paleovegetation shifts throughout the late Pleistocene, within a 100,000+ yr interval (~ 115-15 ka) of terrestrial sediments from the mid-Atlantic Region (MAR) of North America. High-resolution analyses of fossil pollen from one core locality revealed a continuously shifting sequence of thermally dependent forest assemblages, ranging between two endmembers: subtropical oak-tupelo-bald cypress-gum forest and high boreal spruce-pine forest. Sedimentary textural evidence indicates fluvial, paludal, and loess deposition, and paleosol formation, representing sequential freshwater to subaerial environments in which this record was deposited. Its total age-depth model, based on radiocarbon and optically stimulated luminescence ages, ranges from terrestrial oxygen isotope stages (OIS) 6 to 1. The particular core sub-interval presented here is correlative in trend and timing to that portion of the oxygen isotope sequence common among several Greenland ice cores: interstades GI2 to GI24 (≈ OIS2-5 d). This site thus provides the first evidence for an essentially complete series of 'Dansgaard-Oeschger' climate events in the MAR. These data reveal that the ~ 100,000 yr preceding the Late Glacial and Holocene in the MAR of North America were characterized by frequently and dynamically changing climate states, and by vegetation shifts that closely tracked the Greenland paleoclimate sequence.

  8. Large-scale growth of Cu2ZnSnSe4 and Cu2ZnSnSe4/Cu2ZnSnS4 core/shell nanowires

    NASA Astrophysics Data System (ADS)

    Li, Z. Q.; Shi, J. H.; Liu, Q. Q.; Chen, Y. W.; Sun, Z.; Yang, Z.; Huang, S. M.

    2011-07-01

    We present a fast and simple protocol for large-scale preparation of quaternary Cu2ZnSnSe4 (CZTSe), as well as CZTSe/Cu2ZnSnS4 (CZTS) core/shell nanowires using CuSe nanowire bundles as self-sacrificial templates. CuSe nanowire bundles were synthesized by reacting Cu2 - xSe nanowire bundles with sodium citrate solution. CZTSe nanowires were prepared by reacting CuSe nanowire bundles with Zn(CH3COO)2 and SnCl2 in triethylene glycol. X-ray diffraction (XRD) and selected area electron diffraction studies show that stannite CZTSe is formed. The formed CZTSe nanowire bundles have diameters of 200-400 nm and lengths of up to hundreds of micrometers. CZTSe/CZTS nanocable bundles with similar morphologies were grown by the addition of some elemental sulfur to the reaction system for growth of CZTSe bundles. The stannite CZTSe/kesterite CZTS core/shell structure of the grown nanocables was confirmed by XRD and high-resolution transmission electron microscope investigation. The influence of S/Se molar ratio in the reaction system on the crystallographic structures and optical properties of CZTSe/CZTS nanocables was studied. The obtained CZTSe/CZTS core/shell nanocable bundles show broad and enhanced optical absorption over the visible and near-infrared region, which is promising for use in photovoltaic applications.

  9. Focussing on Generic Skills in Training Packages.

    ERIC Educational Resources Information Center

    Dawe, Susan

    A study assessed whether training packages gave sufficient focus to attainment of generic skills and examined approaches that can be used to enhance the delivery of these skills so students are better prepared for the new demands of the workplace. A literature review and consultations with stakeholders provided information on development of the…

  10. A Generic Biokinetic Model for C-14

    SciTech Connect

    Manger, Ryan P

    2011-01-01

    The generic biokinetic model currently recommended by the International Commission on Radiological Protection (ICRP) for the treatment of systemic radiocarbon assumes uniform distribution of activity in tissues and a biological half-time of 40 d. This model is intended to generate cautiously high estimates of dose per unit intake of C-14 and, in fact, generally predicts a much higher effective dose than systemic models that have been developed on the basis of biokinetic studies of specific carbon compounds. The simplistic model formulation precludes its application as a bioassay model or adjustment to fit case-specific bioassay data. This paper proposes a new generic biokinetic model for systemic radiocarbon that is less conservative than the current ICRP model but maintains sufficient conservatism to overestimate the effective dose coefficients generated by most radiocarbon-compound-specific models. The proposed model includes two systemic pools with different biological half-times representing an initial systemic form of absorbed radiocarbon, a submodel describing the behaviour of labelled carbon dioxide produced in vivo, and three excretion pathways: breath, urine and faeces. Generic excretion rates along each path are based on multi-phase excretion curves observed in experimental studies of radiocarbons. The generic model structure is designed so that the user may adjust the level of dosimetric conservatism to fit the information at hand and may adjust parameter values for consistency with subject-specific or site-specific bioassay data.

  11. Defining and Assessing Competence in Generic Skills.

    ERIC Educational Resources Information Center

    Tait, Hilary; Godfrey, Helen

    1999-01-01

    Argues that attempts to provide university students in the United Kingdom with generic skills (such as study and information technology skills) are hampered by the differing needs and expectations of various disciplines and courses and of diverse student population groups. Describes and critically analyzes a case study of one such course,…

  12. Baldrige Theory into Practice: A Generic Model

    ERIC Educational Resources Information Center

    Arif, Mohammed

    2007-01-01

    Purpose: The education system globally has moved from a push-based or producer-centric system to a pull-based or customer centric system. Malcolm Baldrige Quality Award (MBQA) model happens to be one of the latest additions to the pull based models. The purpose of this paper is to develop a generic framework for MBQA that can be used by…

  13. Towards One Generic Name for Monophyletic Lineages

    Technology Transfer Automated Retrieval System (TEKTRAN)

    With the integration of asexually reproducing fungi into meaningful phylogenies, the need to use the same generic name for a monophyletic lineage has become urgent. At present Article 59 of the International Code of Botanical Nomenclature (ICBN) requires the use of a sexual state name for sexually r...

  14. A generic biokinetic model for Carbon-14.

    PubMed

    Manger, R P

    2011-01-01

    The generic biokinetic model currently recommended by the International Commission on Radiological Protection (ICRP) for the treatment of systemic radiocarbon assumes uniform distribution of activity in tissues and a biological half-time of 40 d. This model is intended to generate cautiously high estimates of dose per unit intake of C-14 and, in fact, generally predicts a much higher effective dose than systemic models that have been developed on the basis of biokinetic studies of specific carbon compounds. The simplistic model formulation precludes its application as a bioassay model or adjustment to fit case-specific bioassay data. This paper proposes a new generic biokinetic model for systemic radiocarbon that is less conservative than the current ICRP model but maintains sufficient conservatism to overestimate the effective dose coefficients generated by most radiocarbon-compound-specific models. The proposed model includes two systemic pools with different biological half-times representing an initial systemic form of absorbed radiocarbon, a submodel describing the behaviour of labelled carbon dioxide produced in vivo, and three excretion pathways: breath, urine and faeces. Generic excretion rates along each path are based on multi-phase excretion curves observed in experimental studies of radiocarbons. The generic model structure is designed so that the user may adjust the level of dosimetric conservatism to fit the information at hand and may adjust parameter values for consistency with subject-specific or site-specific bioassay data. PMID:21075764

  15. Comparison of Generic Accelerated Nursing Students

    ERIC Educational Resources Information Center

    Kaddorura, Mahmood; Williams, Collette

    2012-01-01

    Case study pedagogy is a teaching strategy in which teachers hope to help students develop and use critical thinking (CT) abilities. This study compared CT skills of 75 second year generic accelerated baccalaureate nursing students during their Fundamentals of Nursing course before and after being educated using case study pedagogical method.…

  16. A Generic Archive Protocol and an Implementation

    NASA Astrophysics Data System (ADS)

    Jordan, J. M.; Jennings, D. G.; McGlynn, T. A.; Ruggiero, N. G.; Serlemitsos, T. A.

    1993-01-01

    Archiving vast amounts of data has become a major part of every scientific space mission today. GRASP, the Generic Retrieval/Ar\\-chive Services Protocol, addresses the question of how to archive the data collected in an environment where the underlying hardware archives and computer hosts may be rapidly changing.

  17. Reduction of TEM/ETG-scale Density Fluctuations in the Core and Edge of H-mode DIII-D Plasmas

    NASA Astrophysics Data System (ADS)

    Schmitz, L.

    2008-11-01

    Improved confinement during H-mode has been linked to ExB shear suppression of large-scale (kθρs<=0.3) turbulence within an edge transport barrier. While larger scale eddies are preferentially suppressed by increased shear flow in this paradigm, the effects on smaller scale (TEM/ETG-scale) turbulence are less certain. Recent results from DIII-D provide the first experimental evidence that intermediate-scale turbulence (1 < kθρs<=3) together with larger-scale electron temperature fluctuations [1] are also reduced promptly at the L-H transition. These reductions are not confined to the edge region. Intermediate-scale density fluctuations obtained via Doppler backscattering, are significantly reduced (30%-50%) over a range of normalized radii (0.5 <=r/a <=0.85) within a few ms of the L-H transition. A larger reduction (>=75%) is observed at the top of the pedestal (r/a ˜0.9) within 0.2 ms. In addition, low-k electron temperature fluctuations (kθρs<=0.3, from correlation ECE) are strongly reduced (>75%) at the L-H mode transition and during QH-mode (r/a ˜0.7). Gyrokinetic simulation results [2] predict that Te fluctuations contribute significantly to L-mode electron heat transport, hence, the observed reduction is likely an important factor in the observed improved H-mode electron heat confinement (χe^QH/χ3^L < 0.25). Doppler backscattering is also utilized to probe time-dependent shear flows (i.e. zonal flows). The results clearly indicate that zonal flow levels are anti-correlated with the amplitude of intermediate-scale density turbulence in L-mode, suggesting that zonal flows play an important role in turbulence/transport regulation. 3pt [1] L. Schmitz et al., Phys. Rev. Lett. 100, 035002 (2008).[2] A.E. White et al., Phys. Plasmas 15, 056116 (2008).

  18. Mars' Inner Core

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This figure shows a cross-section of the planet Mars revealing an inner, high density core buried deep within the interior. Dipole magnetic field lines are drawn in blue, showing the global scale magnetic field that one associates with dynamo generation in the core. Mars must have one day had such a field, but today it is not evident. Perhaps the energy source that powered the early dynamo has shut down. The differentiation of the planet interior - heavy elements like iron sinking towards the center of the planet - can provide energy as can the formation of a solid core from the liquid.

    The Jet Propulsion Laboratory's Mars Surveyor Operations Project operates the Mars Global Surveyor spacecraft with its industrial partner, Lockheed Martin Astronautics, from facilities in Pasadena, CA and Denver, CO. JPL is an operating division of California Institute of Technology (Caltech).

  19. Consistently dated records from the Greenland GRIP, GISP2 and NGRIP ice cores for the past 104 ka reveal regional millennial-scale δ18O gradients with possible Heinrich event imprint

    NASA Astrophysics Data System (ADS)

    Seierstad, Inger K.; Abbott, Peter M.; Bigler, Matthias; Blunier, Thomas; Bourne, Anna J.; Brook, Edward; Buchardt, Susanne L.; Buizert, Christo; Clausen, Henrik B.; Cook, Eliza; Dahl-Jensen, Dorthe; Davies, Siwan M.; Guillevic, Myriam; Johnsen, Sigfús J.; Pedersen, Desirée S.; Popp, Trevor J.; Rasmussen, Sune O.; Severinghaus, Jeffrey P.; Svensson, Anders; Vinther, Bo M.

    2014-12-01

    We present a synchronization of the NGRIP, GRIP and GISP2 ice cores onto a master chronology extending back to 104 ka before present, providing a consistent chronological framework for these three Greenland records. The synchronization aligns distinct peaks in volcanic proxy records and other impurity records (chemo-stratigraphic matching) and assumes that these layers of elevated impurity content represent the same, instantaneous event in the past at all three sites. More than 900 marker horizons between the three cores have been identified and our matching is independently confirmed by 24 new and previously identified volcanic ash (tephra) tie-points. Using the reference horizons, we transfer the widely used Greenland ice-core chronology, GICC05modelext, to the two Summit cores, GRIP and GISP2. Furthermore, we provide gas chronologies for the Summit cores that are consistent with the GICC05modelext timescale by utilizing both existing and new gas data (CH4 concentration and δ15N of N2). We infer that the accumulation contrast between the stadial and interstadial phases of the glacial period was ˜10% greater at Summit compared to at NGRIP. The δ18O temperature-proxy records from NGRIP, GRIP, and GISP2 are generally very similar and display synchronous behaviour at climate transitions. The δ18O differences between Summit and NGRIP, however, changed slowly over the Last Glacial-Interglacial cycle and also underwent abrupt millennial-to-centennial-scale variations. We suggest that this observed latitudinal δ18O gradient in Greenland during the glacial period is the result of 1) relatively higher degree of precipitation with a Pacific signature at NGRIP, 2) increased summer bias in precipitation at Summit, and 3) enhanced Rayleigh distillation due to an increased source-to-site distance and a potentially larger source-to-site temperature gradient. We propose that these processes are governed by changes in the North American Ice Sheet (NAIS) volume and North

  20. Hydrodynamic instabilities provide a generic route to spontaneous biomimetic oscillations in chemomechanically active filaments

    PubMed Central

    Laskar, Abhrajit; Singh, Rajeev; Ghose, Somdeb; Jayaraman, Gayathri; Kumar, P. B. Sunil; Adhikari, R.

    2013-01-01

    Non-equilibrium processes which convert chemical energy into mechanical motion enable the motility of organisms. Bundles of inextensible filaments driven by energy transduction of molecular motors form essential components of micron-scale motility engines like cilia and flagella. The mimicry of cilia-like motion in recent experiments on synthetic active filaments supports the idea that generic physical mechanisms may be sufficient to generate such motion. Here we show, theoretically, that the competition between the destabilising effect of hydrodynamic interactions induced by force-free and torque-free chemomechanically active flows, and the stabilising effect of nonlinear elasticity, provides a generic route to spontaneous oscillations in active filaments. These oscillations, reminiscent of prokaryotic and eukaryotic flagellar motion, are obtained without having to invoke structural complexity or biochemical regulation. This minimality implies that biomimetic oscillations, previously observed only in complex bundles of active filaments, can be replicated in simple chains of generic chemomechanically active beads. PMID:23752497

  1. Hydrodynamic instabilities provide a generic route to spontaneous biomimetic oscillations in chemomechanically active filaments

    NASA Astrophysics Data System (ADS)

    Laskar, Abhrajit; Singh, Rajeev; Ghose, Somdeb; Jayaraman, Gayathri; Kumar, P. B. Sunil; Adhikari, R.

    2013-06-01

    Non-equilibrium processes which convert chemical energy into mechanical motion enable the motility of organisms. Bundles of inextensible filaments driven by energy transduction of molecular motors form essential components of micron-scale motility engines like cilia and flagella. The mimicry of cilia-like motion in recent experiments on synthetic active filaments supports the idea that generic physical mechanisms may be sufficient to generate such motion. Here we show, theoretically, that the competition between the destabilising effect of hydrodynamic interactions induced by force-free and torque-free chemomechanically active flows, and the stabilising effect of nonlinear elasticity, provides a generic route to spontaneous oscillations in active filaments. These oscillations, reminiscent of prokaryotic and eukaryotic flagellar motion, are obtained without having to invoke structural complexity or biochemical regulation. This minimality implies that biomimetic oscillations, previously observed only in complex bundles of active filaments, can be replicated in simple chains of generic chemomechanically active beads.

  2. Core layering

    NASA Astrophysics Data System (ADS)

    Jacobson, S. A.; Rubie, D. C.; Hernlund, J. W.; Morbidelli, A.

    2015-12-01

    We have created a planetary accretion and differentiation model that self-consistently builds and evolves Earth's core. From this model, we show that the core grows stably stratified as the result of rising metal-silicate equilibration temperatures and pressures, which increases the concentrations of light element impurities into each newer core addition. This stable stratification would naturally resist convection and frustrate the onset of a geodynamo, however, late giant impacts could mechanically mix the distinct accreted core layers creating large homogenous regions. Within these regions, a geodynamo may operate. From this model, we interpret the difference between the planetary magnetic fields of Earth and Venus as a difference in giant impact histories. Our planetary accretion model is a numerical N-body integration of the Grand Tack scenario [1]—the most successful terrestrial planet formation model to date [2,3]. Then, we take the accretion histories of Earth-like and Venus-like planets from this model and post-process the growth of each terrestrial planet according to a well-tested planetary differentiation model [4,5]. This model fits Earth's mantle by modifying the oxygen content of the pre-cursor planetesimals and embryos as well as the conditions of metal-silicate equilibration. Other non-volatile major, minor and trace elements included in the model are assumed to be in CI chondrite proportions. The results from this model across many simulated terrestrial planet growth histories are robust. If the kinetic energy delivered by larger impacts is neglected, the core of each planet grows with a strong stable stratification that would significantly impede convection. However, if giant impact mixing is very efficient or if the impact history delivers large impacts late, than the stable stratification can be removed. [1] Walsh et al. Nature 475 (2011) [2] O'Brien et al. Icarus 223 (2014) [3] Jacobson & Morbidelli PTRSA 372 (2014) [4] Rubie et al. EPSL 301

  3. Fissioning Plasma Core Reactor

    NASA Technical Reports Server (NTRS)

    Albright, Dennis; Butler, Carey; West, Nicole; Cole, John W. (Technical Monitor)

    2002-01-01

    Institute for Scientific Research, Inc. (ISR) research program consist of: 1.Study core physics by adapting existing codes: MCNP4C - Monte Carlo code; COMBINE/VENTURE - diffusion theory; SCALE4 - Monte Carlo, with many utility codes. 2. Determine feasibility and study major design parameters: fuel selection, temperature and reflector sizing. 3. Study reactor kinetics: develop QCALC1 to model point kinetics; study dynamic behavior of the power release.

  4. Core-collapse Supernovae

    SciTech Connect

    Hix, William Raphael; Lentz, E. J.; Baird, Mark L; Chertkow, Merek A; Lee, Ching-Tsai; Blondin, J. M.; Bruenn, S. W.; Messer, Bronson; Mezzacappa, Anthony

    2013-01-01

    Marking the inevitable death of a massive star, and the birth of a neutron star or black hole, core-collapse supernovae bring together physics at a wide range in spatial scales, from kilometer-sized hydrodynamic motions (growing to gigameter scale) down to femtometer scale nuclear reactions. Carrying 10$^{51}$ ergs of kinetic energy and a rich-mix of newly synthesized atomic nuclei, core-collapse supernovae are the preeminent foundries of the nuclear species which make up ourselves and our solar system. We will discuss our emerging understanding of the convectively unstable, neutrino-driven explosion mechanism, based on increasingly realistic neutrino-radiation hydrodynamic simulations that include progressively better nuclear and particle physics. Recent multi-dimensional models with spectral neutrino transport from several research groups, which slowly develop successful explosions for a range of progenitors, have motivated changes in our understanding of the neutrino reheating mechanism. In a similar fashion, improvements in nuclear physics, most notably explorations of weak interactions on nuclei and the nuclear equation of state, continue to refine our understanding of how supernovae explode. Recent progress on both the macroscopic and microscopic effects that affect core-collapse supernovae are discussed.

  5. 40 CFR 721.10258 - Aromatic hydrocarbon (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Aromatic hydrocarbon (generic). 721... Substances § 721.10258 Aromatic hydrocarbon (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as aromatic hydrocarbon (PMN...

  6. 40 CFR 721.10258 - Aromatic hydrocarbon (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Aromatic hydrocarbon (generic). 721... Substances § 721.10258 Aromatic hydrocarbon (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as aromatic hydrocarbon (PMN...

  7. 40 CFR 721.10258 - Aromatic hydrocarbon (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Aromatic hydrocarbon (generic). 721... Substances § 721.10258 Aromatic hydrocarbon (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as aromatic hydrocarbon (PMN...

  8. 40 CFR 721.3080 - Substituted phosphate ester (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted phosphate ester (generic... Substances § 721.3080 Substituted phosphate ester (generic). (a) Chemical substances and significant new uses subject to reporting. (1) The chemical substance identified generically as a substituted phosphate...

  9. 40 CFR 721.10689 - Organo zinc salts (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Organo zinc salts (generic). 721.10689... Substances § 721.10689 Organo zinc salts (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as organo zinc salts (PMN...

  10. 40 CFR 721.10302 - Zinc ammonium phosphate (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Zinc ammonium phosphate (generic). 721... Substances § 721.10302 Zinc ammonium phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as zinc ammonium phosphate (PMN...

  11. 40 CFR 721.10302 - Zinc ammonium phosphate (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Zinc ammonium phosphate (generic). 721... Substances § 721.10302 Zinc ammonium phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as zinc ammonium phosphate (PMN...

  12. 40 CFR 721.10302 - Zinc ammonium phosphate (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Zinc ammonium phosphate (generic). 721... Substances § 721.10302 Zinc ammonium phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as zinc ammonium phosphate (PMN...

  13. 40 CFR 721.10524 - Fluorinated alkylsulfonamidol urethane polymer (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... polymer (generic). 721.10524 Section 721.10524 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Specific Chemical Substances § 721.10524 Fluorinated alkylsulfonamidol urethane polymer (generic). (a... generically as fluorinated alkylsulfonamidol urethane polymer (PMN P-11-384) is subject to reporting...

  14. 40 CFR 721.10524 - Fluorinated alkylsulfonamidol urethane polymer (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... polymer (generic). 721.10524 Section 721.10524 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Specific Chemical Substances § 721.10524 Fluorinated alkylsulfonamidol urethane polymer (generic). (a... generically as fluorinated alkylsulfonamidol urethane polymer (PMN P-11-384) is subject to reporting...

  15. 40 CFR 721.9959 - Polyurethane polymer (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Polyurethane polymer (generic). 721... Substances § 721.9959 Polyurethane polymer (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a polyurethane polymer (PMN...

  16. 40 CFR 721.324 - Alkoxylated acrylate polymer (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Alkoxylated acrylate polymer (generic... Substances § 721.324 Alkoxylated acrylate polymer (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkoxylated acrylate...

  17. 40 CFR 721.9959 - Polyurethane polymer (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Polyurethane polymer (generic). 721... Substances § 721.9959 Polyurethane polymer (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a polyurethane polymer (PMN...

  18. 40 CFR 721.324 - Alkoxylated acrylate polymer (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Alkoxylated acrylate polymer (generic... Substances § 721.324 Alkoxylated acrylate polymer (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkoxylated acrylate...

  19. 40 CFR 721.324 - Alkoxylated acrylate polymer (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Alkoxylated acrylate polymer (generic... Substances § 721.324 Alkoxylated acrylate polymer (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkoxylated acrylate...

  20. 40 CFR 721.9959 - Polyurethane polymer (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Polyurethane polymer (generic). 721... Substances § 721.9959 Polyurethane polymer (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a polyurethane polymer (PMN...

  1. 40 CFR 721.10460 - Azo nickel complex (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Azo nickel complex (generic). 721... Substances § 721.10460 Azo nickel complex (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as azo nickel complex (PMN...

  2. 40 CFR 721.10460 - Azo nickel complex (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Azo nickel complex (generic). 721... Substances § 721.10460 Azo nickel complex (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as azo nickel complex (PMN...

  3. 40 CFR 721.10035 - Alkylbenzene sulfonate (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alkylbenzene sulfonate (generic). 721... Substances § 721.10035 Alkylbenzene sulfonate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkylbenzene sulfonate...

  4. 40 CFR 721.10035 - Alkylbenzene sulfonate (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Alkylbenzene sulfonate (generic). 721... Substances § 721.10035 Alkylbenzene sulfonate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkylbenzene sulfonate...

  5. Emerging Patterns of Initial Preparation for Teachers: Generic Teaching Domains.

    ERIC Educational Resources Information Center

    Denemark, George; Nelli, Elizabeth

    Generic teaching knowledge and skill is seen as a central component of preservice teacher education programs. Generic domains of teaching are the common base of knowledge and skills important to all teachers regardless of subject matter or grade level. Most classifications of generic teaching skills fall generally into one of two categories, one…

  6. 40 CFR 721.10318 - Mannich bases (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Mannich bases (generic). 721.10318... Substances § 721.10318 Mannich bases (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as mannich bases (PMNs P-02-1078 and...

  7. 40 CFR 721.10318 - Mannich bases (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Mannich bases (generic). 721.10318... Substances § 721.10318 Mannich bases (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as mannich bases (PMNs P-02-1078 and...

  8. 40 CFR 721.10318 - Mannich bases (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Mannich bases (generic). 721.10318... Substances § 721.10318 Mannich bases (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as mannich bases (PMNs P-02-1078 and...

  9. Defining and Comparing Generic Competences in Higher Education

    ERIC Educational Resources Information Center

    Kallioinen, Outi

    2010-01-01

    In this article the author discusses the importance of defining generic competences in alignment with the European definitions. As a case study the generic competences defined by Laurea University of Applied Sciences are compared with European definitions of generic competences. The purpose is to open up the various perspectives within this…

  10. 40 CFR 721.9720 - Disubstituted alkyl triazines (generic name).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Disubstituted alkyl triazines (generic... Specific Chemical Substances § 721.9720 Disubstituted alkyl triazines (generic name). Link to an amendment... reporting. (1) The chemical substances identified generically as disubstituted alkyl triazines (PMNs...

  11. 40 CFR 721.10233 - Linear alkyl epoxide (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Linear alkyl epoxide (generic). 721... Substances § 721.10233 Linear alkyl epoxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as linear alkyl epoxide (PMN...

  12. 40 CFR 721.555 - Alkyl amino nitriles (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Alkyl amino nitriles (generic). 721... Substances § 721.555 Alkyl amino nitriles (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as alkyl amino nitriles (PMNs...

  13. 40 CFR 721.10341 - Amino alkyl organoborane (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Amino alkyl organoborane (generic... Specific Chemical Substances § 721.10341 Amino alkyl organoborane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as amino...

  14. 40 CFR 721.10053 - Alkyl silane methacrylate (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alkyl silane methacrylate (generic... Specific Chemical Substances § 721.10053 Alkyl silane methacrylate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkyl...

  15. 40 CFR 721.10430 - Tetra alkyl ammonium salt (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Tetra alkyl ammonium salt (generic... Specific Chemical Substances § 721.10430 Tetra alkyl ammonium salt (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as tetra...

  16. 40 CFR 721.1852 - Di-alkyl borane (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Di-alkyl borane (generic). 721.1852... Substances § 721.1852 Di-alkyl borane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as di-alkyl borane (PMN P-00-1087) is...

  17. 40 CFR 721.2155 - Alkoxyamino-alkyl-coumarin (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alkoxyamino-alkyl-coumarin (generic... Substances § 721.2155 Alkoxyamino-alkyl-coumarin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  18. 40 CFR 721.10053 - Alkyl silane methacrylate (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Alkyl silane methacrylate (generic... Specific Chemical Substances § 721.10053 Alkyl silane methacrylate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkyl...

  19. 40 CFR 721.555 - Alkyl amino nitriles (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Alkyl amino nitriles (generic). 721... Substances § 721.555 Alkyl amino nitriles (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as alkyl amino nitriles (PMNs...

  20. 40 CFR 721.10317 - Alkyl phosphate derivative (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Alkyl phosphate derivative (generic... Specific Chemical Substances § 721.10317 Alkyl phosphate derivative (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  1. 40 CFR 721.10385 - Phenoxy alkyl ether (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Phenoxy alkyl ether (generic). 721... Substances § 721.10385 Phenoxy alkyl ether (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as phenoxy alkyl ether (PMN...

  2. 40 CFR 721.10073 - Modified alkyl acrylamide (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Modified alkyl acrylamide (generic... Specific Chemical Substances § 721.10073 Modified alkyl acrylamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified...

  3. 40 CFR 721.10385 - Phenoxy alkyl ether (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Phenoxy alkyl ether (generic). 721... Substances § 721.10385 Phenoxy alkyl ether (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as phenoxy alkyl ether (PMN...

  4. 40 CFR 721.9572 - Substituted alkyl sulfonamide (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Substituted alkyl sulfonamide (generic... Substances § 721.9572 Substituted alkyl sulfonamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted...

  5. 40 CFR 721.647 - Alkoxylated alkyl amine (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Alkoxylated alkyl amine (generic). 721... Substances § 721.647 Alkoxylated alkyl amine (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as an alkoxylated alkyl amine...

  6. 40 CFR 721.10430 - Tetra alkyl ammonium salt (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Tetra alkyl ammonium salt (generic... Specific Chemical Substances § 721.10430 Tetra alkyl ammonium salt (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as tetra...

  7. 40 CFR 721.2155 - Alkoxyamino-alkyl-coumarin (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Alkoxyamino-alkyl-coumarin (generic... Substances § 721.2155 Alkoxyamino-alkyl-coumarin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  8. 40 CFR 721.647 - Alkoxylated alkyl amine (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Alkoxylated alkyl amine (generic). 721... Substances § 721.647 Alkoxylated alkyl amine (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as an alkoxylated alkyl amine...

  9. 40 CFR 721.10053 - Alkyl silane methacrylate (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Alkyl silane methacrylate (generic... Specific Chemical Substances § 721.10053 Alkyl silane methacrylate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkyl...

  10. 40 CFR 721.10385 - Phenoxy alkyl ether (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Phenoxy alkyl ether (generic). 721... Substances § 721.10385 Phenoxy alkyl ether (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as phenoxy alkyl ether (PMN...

  11. 40 CFR 721.10233 - Linear alkyl epoxide (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Linear alkyl epoxide (generic). 721... Substances § 721.10233 Linear alkyl epoxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as linear alkyl epoxide (PMN...

  12. 40 CFR 721.10341 - Amino alkyl organoborane (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Amino alkyl organoborane (generic... Specific Chemical Substances § 721.10341 Amino alkyl organoborane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as amino...

  13. 40 CFR 721.2155 - Alkoxyamino-alkyl-coumarin (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Alkoxyamino-alkyl-coumarin (generic... Substances § 721.2155 Alkoxyamino-alkyl-coumarin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  14. 40 CFR 721.10073 - Modified alkyl acrylamide (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Modified alkyl acrylamide (generic... Specific Chemical Substances § 721.10073 Modified alkyl acrylamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified...

  15. 40 CFR 721.1852 - Di-alkyl borane (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Di-alkyl borane (generic). 721.1852... Substances § 721.1852 Di-alkyl borane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as di-alkyl borane (PMN P-00-1087) is...

  16. 40 CFR 721.10053 - Alkyl silane methacrylate (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Alkyl silane methacrylate (generic... Specific Chemical Substances § 721.10053 Alkyl silane methacrylate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkyl...

  17. 40 CFR 721.1852 - Di-alkyl borane (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Di-alkyl borane (generic). 721.1852... Substances § 721.1852 Di-alkyl borane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as di-alkyl borane (PMN P-00-1087) is...

  18. 40 CFR 721.1852 - Di-alkyl borane (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Di-alkyl borane (generic). 721.1852... Substances § 721.1852 Di-alkyl borane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as di-alkyl borane (PMN P-00-1087) is...

  19. 40 CFR 721.9572 - Substituted alkyl sulfonamide (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Substituted alkyl sulfonamide (generic... Substances § 721.9572 Substituted alkyl sulfonamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted...

  20. 40 CFR 721.10317 - Alkyl phosphate derivative (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Alkyl phosphate derivative (generic... Specific Chemical Substances § 721.10317 Alkyl phosphate derivative (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  1. 40 CFR 721.9572 - Substituted alkyl sulfonamide (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Substituted alkyl sulfonamide (generic... Substances § 721.9572 Substituted alkyl sulfonamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted...

  2. 40 CFR 721.10073 - Modified alkyl acrylamide (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Modified alkyl acrylamide (generic... Specific Chemical Substances § 721.10073 Modified alkyl acrylamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified...

  3. 40 CFR 721.10073 - Modified alkyl acrylamide (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Modified alkyl acrylamide (generic... Specific Chemical Substances § 721.10073 Modified alkyl acrylamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified...

  4. 40 CFR 721.9572 - Substituted alkyl sulfonamide (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted alkyl sulfonamide (generic... Substances § 721.9572 Substituted alkyl sulfonamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted...

  5. 40 CFR 721.10317 - Alkyl phosphate derivative (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Alkyl phosphate derivative (generic... Specific Chemical Substances § 721.10317 Alkyl phosphate derivative (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  6. 40 CFR 721.10053 - Alkyl silane methacrylate (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Alkyl silane methacrylate (generic... Specific Chemical Substances § 721.10053 Alkyl silane methacrylate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkyl...

  7. 40 CFR 721.555 - Alkyl amino nitriles (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alkyl amino nitriles (generic). 721... Substances § 721.555 Alkyl amino nitriles (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as alkyl amino nitriles (PMNs...

  8. 40 CFR 721.10233 - Linear alkyl epoxide (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Linear alkyl epoxide (generic). 721... Substances § 721.10233 Linear alkyl epoxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as linear alkyl epoxide (PMN...

  9. 40 CFR 721.555 - Alkyl amino nitriles (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Alkyl amino nitriles (generic). 721... Substances § 721.555 Alkyl amino nitriles (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as alkyl amino nitriles (PMNs...

  10. 40 CFR 721.10073 - Modified alkyl acrylamide (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Modified alkyl acrylamide (generic... Specific Chemical Substances § 721.10073 Modified alkyl acrylamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified...

  11. 40 CFR 721.10341 - Amino alkyl organoborane (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Amino alkyl organoborane (generic... Specific Chemical Substances § 721.10341 Amino alkyl organoborane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as amino...

  12. 40 CFR 721.9572 - Substituted alkyl sulfonamide (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Substituted alkyl sulfonamide (generic... Substances § 721.9572 Substituted alkyl sulfonamide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted...

  13. 40 CFR 721.1852 - Di-alkyl borane (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Di-alkyl borane (generic). 721.1852... Substances § 721.1852 Di-alkyl borane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as di-alkyl borane (PMN P-00-1087) is...

  14. 40 CFR 721.2155 - Alkoxyamino-alkyl-coumarin (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Alkoxyamino-alkyl-coumarin (generic... Substances § 721.2155 Alkoxyamino-alkyl-coumarin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  15. 40 CFR 721.555 - Alkyl amino nitriles (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Alkyl amino nitriles (generic). 721... Substances § 721.555 Alkyl amino nitriles (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as alkyl amino nitriles (PMNs...

  16. 40 CFR 721.647 - Alkoxylated alkyl amine (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Alkoxylated alkyl amine (generic). 721... Substances § 721.647 Alkoxylated alkyl amine (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as an alkoxylated alkyl amine...

  17. 40 CFR 721.2155 - Alkoxyamino-alkyl-coumarin (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Alkoxyamino-alkyl-coumarin (generic... Substances § 721.2155 Alkoxyamino-alkyl-coumarin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as...

  18. 40 CFR 721.647 - Alkoxylated alkyl amine (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Alkoxylated alkyl amine (generic). 721... Substances § 721.647 Alkoxylated alkyl amine (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as an alkoxylated alkyl amine...

  19. 40 CFR 721.647 - Alkoxylated alkyl amine (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Alkoxylated alkyl amine (generic). 721... Substances § 721.647 Alkoxylated alkyl amine (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as an alkoxylated alkyl amine...

  20. 40 CFR 721.2755 - Cycloaliphatic epoxy resin (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Cycloaliphatic epoxy resin (generic... Substances § 721.2755 Cycloaliphatic epoxy resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as cycloaliphatic epoxy resin...

  1. 40 CFR 721.2673 - Aromatic epoxide resin (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Aromatic epoxide resin (generic). 721... Substances § 721.2673 Aromatic epoxide resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as aromatic epoxide resin (PMN...

  2. 40 CFR 721.5905 - Modified phenolic resin (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Modified phenolic resin (generic). 721... Substances § 721.5905 Modified phenolic resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a modified phenolic resin...

  3. 40 CFR 721.5908 - Modified phenolic resin (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Modified phenolic resin (generic). 721... Substances § 721.5908 Modified phenolic resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified phenolic resin (PMN...

  4. Genericization: A Theory of Semantic Broadening in the Marketplace.

    ERIC Educational Resources Information Center

    Clankie, Shawn M.

    2000-01-01

    Genericization theory developed as a response to claims from outside of linguistics that generic use in brand names (for example, using Kleenex as a generic noun for all facial tissues, or Xerox for all photocopiers) is the result of marketing factors or misuse by consumers. This paper examines the linguistic factors that create an environment…

  5. 40 CFR 721.10680 - Fatty acid amides (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Fatty acid amides (generic). 721.10680... Substances § 721.10680 Fatty acid amides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as fatty acid amides (PMNs...

  6. 40 CFR 721.10686 - Fatty acid amides (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Fatty acid amides (generic). 721.10686... Substances § 721.10686 Fatty acid amides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as fatty acid amides (PMNs...

  7. 40 CFR 721.10323 - Glycerol fatty acid ester (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Glycerol fatty acid ester (generic... Specific Chemical Substances § 721.10323 Glycerol fatty acid ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as glycerol...

  8. 40 CFR 721.10691 - Fatty acid amide (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Fatty acid amide (generic). 721.10691... Substances § 721.10691 Fatty acid amide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as fatty acid amide (PMN P-13-267) is...

  9. 40 CFR 721.10323 - Glycerol fatty acid ester (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Glycerol fatty acid ester (generic... Specific Chemical Substances § 721.10323 Glycerol fatty acid ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as glycerol...

  10. 40 CFR 721.10320 - Fatty acid amide (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Fatty acid amide (generic). 721.10320... Substances § 721.10320 Fatty acid amide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as fatty acid amide (PMN P-03-186) is...

  11. 40 CFR 721.10323 - Glycerol fatty acid ester (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Glycerol fatty acid ester (generic... Specific Chemical Substances § 721.10323 Glycerol fatty acid ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as glycerol...

  12. 40 CFR 721.10320 - Fatty acid amide (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Fatty acid amide (generic). 721.10320... Substances § 721.10320 Fatty acid amide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as fatty acid amide (PMN P-03-186) is...

  13. 40 CFR 721.10463 - Fatty acid amides (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Fatty acid amides (generic). 721.10463... Substances § 721.10463 Fatty acid amides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as fatty acid amides (PMN...

  14. Drug patent expirations and the speed of generic entry.

    PubMed Central

    Bae, J P

    1997-01-01

    OBJECTIVE: Using recent data, to analyze the generic drug entry phenomenon to determine the factors that influence the speed and likelihood of generic drug entries. DATA SOURCES: Data for 81 drugs that have lost patent between 1987 and 1994. Patent and exclusive marketing rights expiration dates: Food and Drug Administration's (FDA) Approved Drug Products with Therapeutic Equivalent Evaluations (1986-1989). Generic entry dates: FDA Drug and Device Product Approvals (Jan. 1987-Dec. 1994). Numbers of pending generic applications: FDA Office of Generic Drugs Quantitative Report-ANDAs and AADAs (Nov. 1990-Jan. 1993). Sales revenue: Pharmaceutical Data Services, Walsh-America. STUDY DESIGN: This study appropriately recognizes generic entry as a survival problem, and uses a proportional hazard method for analysis. PRINCIPAL FINDINGS: (1) There is a negative relationship between an innovative drug's sales revenue and the time to generic entry. (2) Entries of generics tend to be slower for drugs that have either very few or a very large number of competing brands in the marketplace. (3) The time to generic entry increased overall between 1987 and 1994. (4) Drugs that primarily treat chronic symptoms tend to enter faster than the types of drugs that primarily treat acute illnesses. CONCLUSIONS: The analysis shows that the generic industry is targeting large-revenue products and chronic drug markets. Entry of a generic drug is influenced by the existing branded substitutes in the marketplace. Surprisingly, the generic drug entry process has slowed despite many changes that would facilitate entry. PMID:9108806

  15. 40 CFR 721.5965 - Substituted S-phenylthiazole (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Substituted S-phenylthiazole (generic... Substances § 721.5965 Substituted S-phenylthiazole (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted...

  16. 40 CFR 721.1680 - Substituted benzoic acid (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Substituted benzoic acid (generic... Substances § 721.1680 Substituted benzoic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted benzoic acid (PMN...

  17. 40 CFR 721.5546 - Halogen substituted oxetanes (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Halogen substituted oxetanes (generic... Substances § 721.5546 Halogen substituted oxetanes (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as halogen substituted...

  18. 40 CFR 721.5546 - Halogen substituted oxetanes (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Halogen substituted oxetanes (generic... Substances § 721.5546 Halogen substituted oxetanes (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as halogen substituted...

  19. 40 CFR 721.5546 - Halogen substituted oxetanes (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Halogen substituted oxetanes (generic... Substances § 721.5546 Halogen substituted oxetanes (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as halogen substituted...

  20. 40 CFR 721.5546 - Halogen substituted oxetanes (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Halogen substituted oxetanes (generic... Substances § 721.5546 Halogen substituted oxetanes (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as halogen substituted...

  1. 40 CFR 721.5546 - Halogen substituted oxetanes (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Halogen substituted oxetanes (generic... Substances § 721.5546 Halogen substituted oxetanes (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as halogen substituted...

  2. 40 CFR 721.5548 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Mixed metal oxide (generic). 721.5548... Substances § 721.5548 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a mixed metal oxide (PMN P-97-956)...

  3. 40 CFR 721.4610 - Mixed metal oxides (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Mixed metal oxides (generic). 721.4610... Substances § 721.4610 Mixed metal oxides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxides (PMN...

  4. 40 CFR 721.4610 - Mixed metal oxides (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Mixed metal oxides (generic). 721.4610... Substances § 721.4610 Mixed metal oxides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxides (PMN...

  5. 40 CFR 721.4610 - Mixed metal oxides (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Mixed metal oxides (generic). 721.4610... Substances § 721.4610 Mixed metal oxides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxides (PMN...

  6. 40 CFR 721.10006 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Mixed metal oxide (generic). 721.10006... Substances § 721.10006 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxide (PMN...

  7. 40 CFR 721.10332 - Lithium metal phosphate (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Lithium metal phosphate (generic). 721... Substances § 721.10332 Lithium metal phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as lithium metal phosphate (PMN...

  8. 40 CFR 721.10631 - Mixed metal borate (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Mixed metal borate (generic). 721... Substances § 721.10631 Mixed metal borate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal borate (PMN...

  9. 40 CFR 721.4610 - Mixed metal oxides (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Mixed metal oxides (generic). 721.4610... Substances § 721.4610 Mixed metal oxides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxides (PMN...

  10. 40 CFR 721.5548 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Mixed metal oxide (generic). 721.5548... Substances § 721.5548 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a mixed metal oxide (PMN P-97-956)...

  11. 40 CFR 721.10006 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Mixed metal oxide (generic). 721.10006... Substances § 721.10006 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxide (PMN...

  12. 40 CFR 721.10628 - Mixed metal oxalate (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Mixed metal oxalate (generic). 721... Substances § 721.10628 Mixed metal oxalate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxalate (PMN...

  13. 40 CFR 721.5548 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Mixed metal oxide (generic). 721.5548... Substances § 721.5548 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a mixed metal oxide (PMN P-97-956)...

  14. 40 CFR 721.10495 - Metal silicate (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Metal silicate (generic). 721.10495... Substances § 721.10495 Metal silicate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as metal silicate (PMN P-05-634) is subject...

  15. 40 CFR 721.4610 - Mixed metal oxides (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Mixed metal oxides (generic). 721.4610... Substances § 721.4610 Mixed metal oxides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxides (PMN...

  16. 40 CFR 721.10495 - Metal silicate (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Metal silicate (generic). 721.10495... Substances § 721.10495 Metal silicate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as metal silicate (PMN P-05-634) is subject...

  17. 40 CFR 721.10332 - Lithium metal phosphate (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Lithium metal phosphate (generic). 721... Substances § 721.10332 Lithium metal phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as lithium metal phosphate (PMN...

  18. 40 CFR 721.10006 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Mixed metal oxide (generic). 721.10006... Substances § 721.10006 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxide (PMN...

  19. 40 CFR 721.5548 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Mixed metal oxide (generic). 721.5548... Substances § 721.5548 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a mixed metal oxide (PMN P-97-956)...

  20. 40 CFR 721.5548 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Mixed metal oxide (generic). 721.5548... Substances § 721.5548 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a mixed metal oxide (PMN P-97-956)...

  1. 40 CFR 721.10006 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Mixed metal oxide (generic). 721.10006... Substances § 721.10006 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxide (PMN...

  2. 40 CFR 721.10332 - Lithium metal phosphate (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Lithium metal phosphate (generic). 721... Substances § 721.10332 Lithium metal phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as lithium metal phosphate (PMN...

  3. 40 CFR 721.10006 - Mixed metal oxide (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Mixed metal oxide (generic). 721.10006... Substances § 721.10006 Mixed metal oxide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxide (PMN...

  4. 40 CFR 721.10631 - Mixed metal borate (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Mixed metal borate (generic). 721... Substances § 721.10631 Mixed metal borate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal borate (PMN...

  5. 40 CFR 721.10628 - Mixed metal oxalate (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Mixed metal oxalate (generic). 721... Substances § 721.10628 Mixed metal oxalate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as mixed metal oxalate (PMN...

  6. 40 CFR 721.638 - Silyl amine, potassium salt (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silyl amine, potassium salt (generic... Substances § 721.638 Silyl amine, potassium salt (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as silyl amine, potassium...

  7. Generic Skills in Vocational Education and Training: Research Readings

    ERIC Educational Resources Information Center

    Gibb, Jennifer, Ed.

    2004-01-01

    Possessing generic or employability skills is vital in the current labour market. The vocational education and training (VET) sector, like other education sectors, must ensure its clients gain and develop generic skills. This volume of readings summarises NCVER managed research into generic skills undertaken in 2001 and 2002. The work covers four…

  8. 40 CFR 721.10128 - Modified imidazole (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Modified imidazole (generic). 721... Substances § 721.10128 Modified imidazole (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified imidazole (PMN...

  9. 40 CFR 721.10128 - Modified imidazole (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Modified imidazole (generic). 721... Substances § 721.10128 Modified imidazole (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified imidazole (PMN...

  10. 40 CFR 721.10128 - Modified imidazole (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Modified imidazole (generic). 721... Substances § 721.10128 Modified imidazole (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified imidazole (PMN...

  11. 40 CFR 721.10128 - Modified imidazole (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Modified imidazole (generic). 721... Substances § 721.10128 Modified imidazole (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified imidazole (PMN...

  12. 40 CFR 721.10128 - Modified imidazole (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Modified imidazole (generic). 721... Substances § 721.10128 Modified imidazole (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified imidazole (PMN...

  13. 40 CFR 721.6005 - Rare earth phosphate (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Rare earth phosphate (generic). 721... Substances § 721.6005 Rare earth phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as rare earth phophate (PMNs...

  14. 40 CFR 721.6005 - Rare earth phosphate (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Rare earth phosphate (generic). 721... Substances § 721.6005 Rare earth phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as rare earth phophate (PMNs...

  15. 40 CFR 721.6005 - Rare earth phosphate (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Rare earth phosphate (generic). 721... Substances § 721.6005 Rare earth phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as rare earth phophate (PMNs...

  16. 40 CFR 721.6005 - Rare earth phosphate (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Rare earth phosphate (generic). 721... Substances § 721.6005 Rare earth phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as rare earth phophate (PMNs...

  17. 40 CFR 721.6005 - Rare earth phosphate (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Rare earth phosphate (generic). 721... Substances § 721.6005 Rare earth phosphate (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as rare earth phophate (PMNs...

  18. 40 CFR 721.5905 - Modified phenolic resin (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Modified phenolic resin (generic). 721... Substances § 721.5905 Modified phenolic resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a modified phenolic resin...

  19. 40 CFR 721.5908 - Modified phenolic resin (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Modified phenolic resin (generic). 721... Substances § 721.5908 Modified phenolic resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as modified phenolic resin (PMN...

  20. 40 CFR 721.2673 - Aromatic epoxide resin (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Aromatic epoxide resin (generic). 721... Substances § 721.2673 Aromatic epoxide resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as aromatic epoxide resin (PMN...

  1. 40 CFR 721.2755 - Cycloaliphatic epoxy resin (generic).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Cycloaliphatic epoxy resin (generic... Substances § 721.2755 Cycloaliphatic epoxy resin (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as cycloaliphatic epoxy resin...

  2. 40 CFR 721.3110 - Polycarboxylic acid ester (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Polycarboxylic acid ester (generic... Substances § 721.3110 Polycarboxylic acid ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a polycarboxylic acid...

  3. 40 CFR 721.10431 - Phosphoric acid esters (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Phosphoric acid esters (generic). 721... Substances § 721.10431 Phosphoric acid esters (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as phosphoric acid esters (PMNs...

  4. 40 CFR 721.1680 - Substituted benzoic acid (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Substituted benzoic acid (generic... Substances § 721.1680 Substituted benzoic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted benzoic acid (PMN...

  5. 40 CFR 721.10320 - Fatty acid amide (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Fatty acid amide (generic). 721.10320... Substances § 721.10320 Fatty acid amide (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as fatty acid amide (PMN P-03-186) is...

  6. 40 CFR 721.10463 - Fatty acid amides (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Fatty acid amides (generic). 721.10463... Substances § 721.10463 Fatty acid amides (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as fatty acid amides (PMN...

  7. 40 CFR 721.3110 - Polycarboxylic acid ester (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Polycarboxylic acid ester (generic... Substances § 721.3110 Polycarboxylic acid ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a polycarboxylic acid...

  8. 40 CFR 721.1680 - Substituted benzoic acid (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Substituted benzoic acid (generic... Substances § 721.1680 Substituted benzoic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted benzoic acid (PMN...

  9. 40 CFR 721.1655 - Alkylbenzenesulfonic acid (generic).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Alkylbenzenesulfonic acid (generic... Substances § 721.1655 Alkylbenzenesulfonic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkylbenzenesulfonic acid...

  10. 40 CFR 721.1680 - Substituted benzoic acid (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Substituted benzoic acid (generic... Substances § 721.1680 Substituted benzoic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted benzoic acid (PMN...

  11. 40 CFR 721.1655 - Alkylbenzenesulfonic acid (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Alkylbenzenesulfonic acid (generic... Substances § 721.1655 Alkylbenzenesulfonic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkylbenzenesulfonic acid...

  12. 40 CFR 721.1655 - Alkylbenzenesulfonic acid (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Alkylbenzenesulfonic acid (generic... Substances § 721.1655 Alkylbenzenesulfonic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkylbenzenesulfonic acid...

  13. 40 CFR 721.1655 - Alkylbenzenesulfonic acid (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Alkylbenzenesulfonic acid (generic... Substances § 721.1655 Alkylbenzenesulfonic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as alkylbenzenesulfonic acid...

  14. 40 CFR 721.1680 - Substituted benzoic acid (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Substituted benzoic acid (generic... Substances § 721.1680 Substituted benzoic acid (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as substituted benzoic acid (PMN...

  15. Professional Teaching Standards: Generic, Subject-Specific or Third Wave?

    ERIC Educational Resources Information Center

    Chadbourne, Rod

    2001-01-01

    Explores the issue of generic versus subject-specific standards in terms of their role in teachers' professional development. Suggests generic and subject-specific standards share a symbiotic relationship. Outlines a basis for a "third wave": some teachers may find at a particular stage in their career that generic standards are more useful than…

  16. 40 CFR 721.10537 - Acrylate ester (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Acrylate ester (generic). 721.10537... Substances § 721.10537 Acrylate ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as acrylate ester (PMN P-01-579) is subject...

  17. 40 CFR 721.3110 - Polycarboxylic acid ester (generic).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Polycarboxylic acid ester (generic... Substances § 721.3110 Polycarboxylic acid ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a polycarboxylic acid...

  18. 40 CFR 721.8660 - Propionic acid methyl ester (generic).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Propionic acid methyl ester (generic... Substances § 721.8660 Propionic acid methyl ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a propionic acid methyl...

  19. 40 CFR 721.10431 - Phosphoric acid esters (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Phosphoric acid esters (generic). 721... Substances § 721.10431 Phosphoric acid esters (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substances identified generically as phosphoric acid esters (PMNs...

  20. 40 CFR 721.8660 - Propionic acid methyl ester (generic).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Propionic acid methyl ester (generic... Substances § 721.8660 Propionic acid methyl ester (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as a propionic acid methyl...