Simulation of a suite of generic long-pulse neutron instruments to optimize the time structure of the European Spallation Source.

PubMed

Lefmann, Kim; Klenø, Kaspar H; Birk, Jonas Okkels; Hansen, Britt R; Holm, Sonja L; Knudsen, Erik; Lieutenant, Klaus; von Moos, Lars; Sales, Morten; Willendrup, Peter K; Andersen, Ken H

2013-05-01

We here describe the result of simulations of 15 generic neutron instruments for the long-pulsed European Spallation Source. All instruments have been simulated for 20 different settings of the source time structure, corresponding to pulse lengths between 1 ms and 2 ms; and repetition frequencies between 10 Hz and 25 Hz. The relative change in performance with time structure is given for each instrument, and an unweighted average is calculated. The performance of the instrument suite is proportional to (a) the peak flux and (b) the duty cycle to a power of approximately 0.3. This information is an important input to determining the best accelerator parameters. In addition, we find that in our simple guide systems, most neutrons reaching the sample originate from the central 3-5 cm of the moderator. This result can be used as an input in later optimization of the moderator design. We discuss the relevance and validity of defining a single figure-of-merit for a full facility and compare with evaluations of the individual instrument classes.

Generic products of antiepileptic drugs: a perspective on bioequivalence, bioavailability, and formulation switches using Monte Carlo simulations.

PubMed

Karalis, Vangelis; Macheras, Panos; Bialer, Meir

2014-01-01

Generic products of antiepileptic drugs (AEDs) are currently a controversial topic as neurologists and patients are reluctant to switch from brand products to generics and to switch between generics. The aim of this study was to provide enlightenment on issues of bioequivalence (BE) and interchangeability of AED products. Monte Carlo simulations of the classic 2 × 2 BE studies were performed to study the effect of sample size, within-subject variability, and the true difference in pharmacokinetic values of the products under comparison on BE acceptance of generic AED products. Simulations were extended to study the comparative performance of two generic AED products against the same innovative product. The simulated results are compared with literature data on AEDs. The question with regard to bioavailability (BA) is whether two formulations are different, while for BE the question is whether two formulations are sufficiently similar in terms of extent and rate of absorption. Therefore, the criteria for BA and BE and the statistical analysis involved in their analysis are different. Two generic formulations that meet regulatory approval requirements for generics by being bioequivalent to the same innovative AED may not be bioequivalent to one another and therefore should not be regarded as equal or as therapeutically equivalent products. A switch from a standard or an immediate-release formulation to a modified-release product, which comprises extended-release or delayed-release formulations, should not be regarded as a switch between generics, but rather as a switch between different formulation types. Switches between bioequivalent generic AED products could potentially lead to larger changes in plasma levels and exposure than the brand-to-generic switch. The simulation work verified the clinical findings that not all generic AED products bioequivalent to the same innovative product are bioequivalent to one another. Two generic formulations that meet regulatory approval requirements for generics, by being bioequivalent to the innovative AED, may not be bioequivalent to one another. Additional BE criteria are needed for a formulation switch, particularly in epilepsy, where a breakthrough seizure may change a patient's status from seizure-free to refractory.

78 FR 37325 - License Renewal of Nuclear Power Plants; Generic Environmental Impact Statement and Standard...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... Nuclear Power Plants; Generic Environmental Impact Statement and Standard Review Plans for Environmental... for Nuclear Power Plants, Supplement 1: Operating License Renewal'' (ESRP). The ESRP serves as a guide... published a final rule, ``Revisions to Environmental Review for Renewal of Nuclear Power Plant Operating...

75 FR 27838 - Notice of Availability of Draft NUREG-1800, Revision 2; “Standard Review Plan for Review of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... Draft NUREG-1801, Revision 2; ``Generic Aging Lessons Learned (GALL) Report'' AGENCY: Nuclear Regulatory... Applications for Nuclear Power Plants ''and draft NUREG-1801, ``Generic Aging Lessons Learned (GALL) Report... Power Plants'' (SRP-LR); and the revised NUREG-1801, ``Generic Aging Lessons Learned (GALL) Report'' for...

Computational effects of inlet representation on powered hypersonic, airbreathing models

NASA Technical Reports Server (NTRS)

Huebner, Lawrence D.; Tatum, Kenneth E.

1993-01-01

Computational results are presented to illustrate the powered aftbody effects of representing the scramjet inlet on a generic hypersonic vehicle with a fairing, to divert the external flow, as compared to an operating flow-through scramjet inlet. This study is pertinent to the ground testing of hypersonic, airbreathing models employing scramjet exhaust flow simulation in typical small-scale hypersonic wind tunnels. The comparison of aftbody effects due to inlet representation is well-suited for computational study, since small model size typically precludes the ability to ingest flow into the inlet and perform exhaust simulation at the same time. Two-dimensional analysis indicates that, although flowfield differences exist for the two types of inlet representations, little, if any, difference in surface aftbody characteristics is caused by fairing over the inlet.

1/f noise and plastic deformation

NASA Astrophysics Data System (ADS)

Laurson, Lasse

2006-11-01

There is increasing evidence from experiments that plastic deformation in the micro- and meso- scopic scales is an intermittent and heterogeneous process, consisting of avalanches of dislocation activity with a power law distribution of sizes. This has been also discovered in many simulation studies of simplified models. In addition to direct studies of the avalanche statistics, interesting information about the dynamics of the system can be obtained by studying the spectral proper- ties of some associated time series, such as the acoustic emission amplitude in an experiment. We discuss the generic aspects concerning the power spectra of such signals, e.g. the possibility of relating the exponent of the power spectrum to the avalanche exponents of the (dislocation) system.

Function of university reactors in operator licensing training for nuclear utilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wicks, F.

1985-11-01

The director of the Division of the US Nuclear Regulatory Commission in generic letter 84-10, dated April 26, 1984, spoke the requirement that applicants for senior reactor operator licenses for power reactors shall have performed then reactor startups. Simulator startups were not acknowledged. Startups performed on a university reactor are acceptable. The content and results of a five-day program combining instruction and experiments with the Rensselaer reactor are summarized.

77 FR 22361 - Energy Northwest, Columbia Generating Station; Final Supplement 47 to the Generic Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-13

...) solar power; (9) wind power; (10) biomass waste; (11) hydroelectric power; (12) ocean wave and current... Nuclear Plants AGENCY: Nuclear Regulatory Commission. ACTION: Final Supplement 47 to the Generic Environmental Impact Statement for License Renewal of Nuclear Plants; issuance. SUMMARY: Notice is hereby given...

Simulation methods supporting homologation of Electronic Stability Control in vehicle variants

NASA Astrophysics Data System (ADS)

Lutz, Albert; Schick, Bernhard; Holzmann, Henning; Kochem, Michael; Meyer-Tuve, Harald; Lange, Olav; Mao, Yiqin; Tosolin, Guido

2017-10-01

Vehicle simulation has a long tradition in the automotive industry as a powerful supplement to physical vehicle testing. In the field of Electronic Stability Control (ESC) system, the simulation process has been well established to support the ESC development and application by suppliers and Original Equipment Manufacturers (OEMs). The latest regulation of the United Nations Economic Commission for Europe UN/ECE-R 13 allows also for simulation-based homologation. This extends the usage of simulation from ESC development to homologation. This paper gives an overview of simulation methods, as well as processes and tools used for the homologation of ESC in vehicle variants. The paper first describes the generic homologation process according to the European Regulation (UN/ECE-R 13H, UN/ECE-R 13/11) and U.S. Federal Motor Vehicle Safety Standard (FMVSS 126). Subsequently the ESC system is explained as well as the generic application and release process at the supplier and OEM side. Coming up with the simulation methods, the ESC development and application process needs to be adapted for the virtual vehicles. The simulation environment, consisting of vehicle model, ESC model and simulation platform, is explained in detail with some exemplary use-cases. In the final section, examples of simulation-based ESC homologation in vehicle variants are shown for passenger cars, light trucks, heavy trucks and trailers. This paper is targeted to give a state-of-the-art account of the simulation methods supporting the homologation of ESC systems in vehicle variants. However, the described approach and the lessons learned can be used as reference in future for an extended usage of simulation-supported releases of the ESC system up to the development and release of driver assistance systems.

78 FR 74175 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-10

... precision requirements or power calculations that justify the proposed sample size, the expected response...: Proposed Collection; Comment Request; Generic Clearance for the Collection of Qualitative Feedback on... Information Collection Request (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback...

Aerodynamics model for a generic ASTOVL lift-fan aircraft

NASA Technical Reports Server (NTRS)

Birckelbaw, Lourdes G.; Mcneil, Walter E.; Wardwell, Douglas A.

1995-01-01

This report describes the aerodynamics model used in a simulation model of an advanced short takeoff and vertical landing (ASTOVL) lift-fan fighter aircraft. The simulation model was developed for use in piloted evaluations of transition and hover flight regimes, so that only low speed (M approximately 0.2) aerodynamics are included in the mathematical model. The aerodynamic model includes the power-off aerodynamic forces and moments and the propulsion system induced aerodynamic effects, including ground effects. The power-off aerodynamics data were generated using the U.S. Air Force Stability and Control Digital DATCOM program and a NASA Ames in-house graphics program called VORVIEW which allows the user to easily analyze arbitrary conceptual aircraft configurations using the VORLAX program. The jet-induced data were generated using the prediction methods of R. E. Kuhn et al., as referenced in this report.

Impact of Reactor Operating Parameters on Cask Reactivity in BWR Burnup Credit

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ilas, Germina; Betzler, Benjamin R; Ade, Brian J

This paper discusses the effect of reactor operating parameters used in fuel depletion calculations on spent fuel cask reactivity, with relevance for boiling-water reactor (BWR) burnup credit (BUC) applications. Assessments that used generic BWR fuel assembly and spent fuel cask configurations are presented. The considered operating parameters, which were independently varied in the depletion simulations for the assembly, included fuel temperature, bypass water density, specific power, and operating history. Different operating history scenarios were considered for the assembly depletion to determine the effect of relative power distribution during the irradiation cycles, as well as the downtime between cycles. Depletion, decay,more » and criticality simulations were performed using computer codes and associated nuclear data within the SCALE code system. Results quantifying the dependence of cask reactivity on the assembly depletion parameters are presented herein.« less

76 FR 35069 - Agency Information Collection Activities; Proposed Collection; Comment Request; Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... precision requirements or power calculations that justify the proposed sample size, the expected response...; Proposed Collection; Comment Request; Generic Clearance for the Collection of Qualitative Feedback on... (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback on Agency Service Delivery...

76 FR 17861 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-31

... requirements or power calculations that justify the proposed sample size, the expected response rate, methods...; Comment Request; Generic Clearance for the Collection of Qualitative Feedback on Agency Service Delivery... Information Collection Request (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback...

76 FR 24920 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... precision requirements or power calculations that justify the proposed sample size, the expected response... Collection; Comment Request; Generic Clearance for the Collection of Qualitative Feedback on Agency Service... Information Collection Request (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback...

Transient performance of fan engine with water ingestion

NASA Technical Reports Server (NTRS)

Murthy, S. N. B.; Mullican, A.

1993-01-01

In a continuing investigation on developing and applying codes for prediction of performance of a turbine jet engine and its components with water ingestion during flight operation, including power settings, and flight altitudes and speed changes, an attempt was made to establish the effects of water ingestion through simulation of a generic high bypass ratio engine with a generic control. In view of the large effects arising in the air compression system and the prediffuser-combustor unit during water ingestion, attention was focused on those effects and the resulting changes in engine performance. Under all conditions of operation, whether ingestion is steady or not, it became evident that water ingestion causes a fan-compressor unit to operate in a time-dependent fashion with periodic features, particularly with respect to the state of water in the span and the film in the casing clearance space, at the exit of the machine. On the other hand, the aerodynamic performance of the unit may be considered as quasi-steady once the distribution of water has attained an equilibrium state with respect to its distribution and motion. For purposes of engine simulation, the performance maps for the generic fan-compressor unit were generated based on the attainment of a quasi-steady state (meaning steady except for long-period variations in performance) during ingestion and operation over a wide enough range of rotational speeds.

Fuzzy Logic Decoupled Lateral Control for General Aviation Airplanes

NASA Technical Reports Server (NTRS)

Duerksen, Noel

1997-01-01

It has been hypothesized that a human pilot uses the same set of generic skills to control a wide variety of aircraft. If this is true, then it should be possible to construct an electronic controller which embodies this generic skill set such that it can successfully control different airplanes without being matched to a specific airplane. In an attempt to create such a system, a fuzzy logic controller was devised to control aileron or roll spoiler position. This controller was used to control bank angle for both a piston powered single engine aileron equipped airplane simulation and a business jet simulation which used spoilers for primary roll control. Overspeed, stall and overbank protection were incorporated in the form of expert systems supervisors and weighted fuzzy rules. It was found that by using the artificial intelligence techniques of fuzzy logic and expert systems, a generic lateral controller could be successfully used on two general aviation aircraft types that have very different characteristics. These controllers worked for both airplanes over their entire flight envelopes. The controllers for both airplanes were identical except for airplane specific limits (maximum allowable airspeed, throttle ]ever travel, etc.). This research validated the fact that the same fuzzy logic based controller can control two very different general aviation airplanes. It also developed the basic controller architecture and specific control parameters required for such a general controller.

Hardware-in-the-Loop Power Extraction Using Different Real-Time Platforms (PREPRINT)

DTIC Science & Technology

2008-07-01

engine controller ( FADEC ). Incorporating various transient subsystem level models into a complex modeling tool can be a challenging process when each...used can also be modified or replaced as appropriate. In its current configuration, the generic turbine engine model’s FADEC runs primarily on a...simulation in real-time, two platforms were tested: dSPACE and National Instruments’ (NI) LabVIEW Real-Time. For both dSPACE and NI, the engine and FADEC

76 FR 25693 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

... requirements or power calculations that justify the proposed sample size, the expected response rate, methods... Collection; Comment Request; Generic Clearance for the Collection of Qualitative Feedback on Agency Service... Collection Request (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback on Agency...

76 FR 21800 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; Generic...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... precision requirements or power calculations that justify the proposed sample size, the expected response... Activities: Submission for OMB Review; Comment Request; Generic Clearance for the Collection of Qualitative... Request (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback on Agency Service...

Stay Alive--Simulation for Situational Safety Awareness

NASA Technical Reports Server (NTRS)

Ruder, Michelle

2008-01-01

STAY ALIVE is an idea for a safety awareness simulation prototype, powered by gaming technology, that would make safety training enlightening, engaging and fun. Recalling initial instructions and using situational awareness principles, participants would escape a fire by choosing the appropriate door. Escape times would be measured while stressors increased. This presentation describes how STAY ALIVE utilizes first person point of view (PoV), a generic scenario, immersion- and presence-enhancing design, and ease of distribution to provide more people opportunity to realize, review, analyze and practice effective awareness behaviors. The goals for this prototype include facilitating interest in first-person PoV safety training and eliciting further suggestions on prevention technologies.

The non-linear power spectrum of the Lyman alpha forest

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arinyo-i-Prats, Andreu; Miralda-Escudé, Jordi; Viel, Matteo

2015-12-01

The Lyman alpha forest power spectrum has been measured on large scales by the BOSS survey in SDSS-III at z∼ 2.3, has been shown to agree well with linear theory predictions, and has provided the first measurement of Baryon Acoustic Oscillations at this redshift. However, the power at small scales, affected by non-linearities, has not been well examined so far. We present results from a variety of hydrodynamic simulations to predict the redshift space non-linear power spectrum of the Lyα transmission for several models, testing the dependence on resolution and box size. A new fitting formula is introduced to facilitate themore » comparison of our simulation results with observations and other simulations. The non-linear power spectrum has a generic shape determined by a transition scale from linear to non-linear anisotropy, and a Jeans scale below which the power drops rapidly. In addition, we predict the two linear bias factors of the Lyα forest and provide a better physical interpretation of their values and redshift evolution. The dependence of these bias factors and the non-linear power on the amplitude and slope of the primordial fluctuations power spectrum, the temperature-density relation of the intergalactic medium, and the mean Lyα transmission, as well as the redshift evolution, is investigated and discussed in detail. A preliminary comparison to the observations shows that the predicted redshift distortion parameter is in good agreement with the recent determination of Blomqvist et al., but the density bias factor is lower than observed. We make all our results publicly available in the form of tables of the non-linear power spectrum that is directly obtained from all our simulations, and parameters of our fitting formula.« less

Development of the Transport Class Model (TCM) Aircraft Simulation From a Sub-Scale Generic Transport Model (GTM) Simulation

NASA Technical Reports Server (NTRS)

Hueschen, Richard M.

2011-01-01

A six degree-of-freedom, flat-earth dynamics, non-linear, and non-proprietary aircraft simulation was developed that is representative of a generic mid-sized twin-jet transport aircraft. The simulation was developed from a non-proprietary, publicly available, subscale twin-jet transport aircraft simulation using scaling relationships and a modified aerodynamic database. The simulation has an extended aerodynamics database with aero data outside the normal transport-operating envelope (large angle-of-attack and sideslip values). The simulation has representative transport aircraft surface actuator models with variable rate-limits and generally fixed position limits. The simulation contains a generic 40,000 lb sea level thrust engine model. The engine model is a first order dynamic model with a variable time constant that changes according to simulation conditions. The simulation provides a means for interfacing a flight control system to use the simulation sensor variables and to command the surface actuators and throttle position of the engine model.

Study of a Simulation Tool to Determine Achievable Control Dynamics and Control Power Requirements with Perfect Tracking

NASA Technical Reports Server (NTRS)

Ostroff, Aaron J.

1998-01-01

This paper contains a study of two methods for use in a generic nonlinear simulation tool that could be used to determine achievable control dynamics and control power requirements while performing perfect tracking maneuvers over the entire flight envelope. The two methods are NDI (nonlinear dynamic inversion) and the SOFFT(Stochastic Optimal Feedforward and Feedback Technology) feedforward control structure. Equivalent discrete and continuous SOFFT feedforward controllers have been developed. These equivalent forms clearly show that the closed-loop plant model loop is a plant inversion and is the same as the NDI formulation. The main difference is that the NDI formulation has a closed-loop controller structure whereas SOFFT uses an open-loop command model. Continuous, discrete, and hybrid controller structures have been developed and integrated into the formulation. Linear simulation results show that seven different configurations all give essentially the same response, with the NDI hybrid being slightly different. The SOFFT controller gave better tracking performance compared to the NDI controller when a nonlinear saturation element was added. Future plans include evaluation using a nonlinear simulation.

GENERIC VERIFICATION PROTOCOL: DISTRIBUTED GENERATION AND COMBINED HEAT AND POWER FIELD TESTING PROTOCOL

EPA Science Inventory

This report is a generic verification protocol by which EPA’s Environmental Technology Verification program tests newly developed equipment for distributed generation of electric power, usually micro-turbine generators and internal combustion engine generators. The protocol will ...

77 FR 12089 - Proposed Generic Communication; Regulatory Issue Summary 2012-XX: Developing Inservice Testing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0048] Proposed Generic Communication; Regulatory Issue... CFR) Part 52, ``Licenses, Certifications, and Approvals for Nuclear Power Plants,'' to satisfy the... inservice testing programs during the initial 120-month program interval following nuclear power plant...

A simulation investigation of the effects of engine-and thrust-response characteristics on helicopter handling qualities

NASA Technical Reports Server (NTRS)

Corless, L. D.; Blanken, C. L.

1983-01-01

A multi-phase program is being conducted to study, in a generic sense and through ground simulation, the effects of engine response, rotor inertia, rpm control, excess power, and vertical damping on specific maneuvers included in nap-of-the-Earth (NOE) operations. The helicopter configuration with an rpm-governed gas-turbine engine are considered. Handling-qualities-criteria data are considered in light of aspects peculiar to rotary-wing and NOE operations. The results of three moving-based piloted simulation studies are summarized and the frequency, characteristics of the helicopter thrust response which set it apart from other VTOL types are explained. Power-system response is affected by both the engine-governor response and the level of rotor inertia. However, results indicate that with unlimited power, variations in engine response can have a significant effect on pilot rating, whereas changes in rotor inertia, in general, do not. The results also show that any pilot interaction required to maintain proper control can significantly degrade handling qualities. Data for variations in vertical damping and collective sensitivity are compared with existing handling-qualities specifications, MIL-F-83300 and AGARD 577, and show a need for higher minimums for both damping and sensitivity for the bob-up task. Results for cases of limited power are also shown.

Distributed plug-and-play optimal generator and load control for power system frequency regulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Changhong; Mallada, Enrique; Low, Steven H.

A distributed control scheme, which can be implemented on generators and controllable loads in a plug-and-play manner, is proposed for power system frequency regulation. The proposed scheme is based on local measurements, local computation, and neighborhood information exchanges over a communication network with an arbitrary (but connected) topology. In the event of a sudden change in generation or load, the proposed scheme can restore the nominal frequency and the reference inter-area power flows, while minimizing the total cost of control for participating generators and loads. Power network stability under the proposed control is proved with a relatively realistic model whichmore » includes nonlinear power flow and a generic (potentially nonlinear or high-order) turbine-governor model, and further with first- and second-order turbine-governor models as special cases. Finally, in simulations, the proposed control scheme shows a comparable performance to the existing automatic generation control (AGC) when implemented only on the generator side, and demonstrates better dynamic characteristics than AGC when each scheme is implemented on both generators and controllable loads. Simulation results also show robustness of the proposed scheme to communication link failure.« less

Distributed plug-and-play optimal generator and load control for power system frequency regulation

DOE PAGES

Zhao, Changhong; Mallada, Enrique; Low, Steven H.; ...

2018-03-14

A distributed control scheme, which can be implemented on generators and controllable loads in a plug-and-play manner, is proposed for power system frequency regulation. The proposed scheme is based on local measurements, local computation, and neighborhood information exchanges over a communication network with an arbitrary (but connected) topology. In the event of a sudden change in generation or load, the proposed scheme can restore the nominal frequency and the reference inter-area power flows, while minimizing the total cost of control for participating generators and loads. Power network stability under the proposed control is proved with a relatively realistic model whichmore » includes nonlinear power flow and a generic (potentially nonlinear or high-order) turbine-governor model, and further with first- and second-order turbine-governor models as special cases. Finally, in simulations, the proposed control scheme shows a comparable performance to the existing automatic generation control (AGC) when implemented only on the generator side, and demonstrates better dynamic characteristics than AGC when each scheme is implemented on both generators and controllable loads. Simulation results also show robustness of the proposed scheme to communication link failure.« less

Computer aided planning of orthopaedic surgeries: the definition of generic planning steps for bone removal procedures.

PubMed

Putzer, David; Moctezuma, Jose Luis; Nogler, Michael

2017-11-01

An increasing number of orthopaedic surgeons are using computer aided planning tools for bone removal applications. The aim of the study was to consolidate a set of generic functions to be used for a 3D computer assisted planning or simulation. A limited subset of 30 surgical procedures was analyzed and verified in 243 surgical procedures of a surgical atlas. Fourteen generic functions to be used in 3D computer assisted planning and simulations were extracted. Our results showed that the average procedure comprises 14 ± 10 (SD) steps with ten different generic planning steps and four generic bone removal steps. In conclusion, the study shows that with a limited number of 14 planning functions it is possible to perform 243 surgical procedures out of Campbell's Operative Orthopedics atlas. The results may be used as a basis for versatile generic intraoperative planning software.

Gravitational clustering in the expanding universe - Controlled high-resolution studies in two dimensions

NASA Technical Reports Server (NTRS)

Beacom, John Francis; Dominik, Kurt G.; Melott, Adrian L.; Perkins, Sam P.; Shandarin, Sergei F.

1991-01-01

Results are presented from a series of gravitational clustering simulations in two dimensions. These simulations are a significant departure from previous work, since in two dimensions one can have large dynamic range in both length scale and mass using present computer technology. Controlled experiments were conducted by varying the slope of power-law initial density fluctuation spectra and varying cutoffs at large k, while holding constant the phases of individual Fourier components and the scale of nonlinearity. Filaments are found in many different simulations, even with pure power-law initial conditions. By direct comparison, filaments, called 'second-generation pancakes' are shown to arise as a consequence of mild nonlinearity on scales much larger than the correlation length and are not relics of an initial lattice or due to sparse sampling of the Fourier components. Bumps of low amplitude in the two-point correlation are found to be generic but usually only statistical fluctuations. Power spectra are much easier to relate to initial conditions, and seem to follow a simple triangular shape (on log-log plot) in the nonlinear regime. The rms density fluctuation with Gaussian smoothing is the most stable indicator of nonlinearity.

Modeling of Protection in Dynamic Simulation Using Generic Relay Models and Settings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samaan, Nader A.; Dagle, Jeffery E.; Makarov, Yuri V.

This paper shows how generic protection relay models available in planning tools can be augmented with settings that are based on NERC standards or best engineering practice. Selected generic relay models in Siemens PSS®E have been used in dynamic simulations in the proposed approach. Undervoltage, overvoltage, underfrequency, and overfrequency relays have been modeled for each generating unit. Distance-relay protection was modeled for transmission system protection. Two types of load-shedding schemes were modeled: underfrequency (frequency-responsive non-firm load shedding) and underfrequency and undervoltage firm load shedding. Several case studies are given to show the impact of protection devices on dynamic simulations. Thismore » is useful for simulating cascading outages.« less

Assessing bioequivalence of generic antiepilepsy drugs.

PubMed

Krauss, Gregory L; Caffo, Brian; Chang, Yi-Ting; Hendrix, Craig W; Chuang, Kelly

2011-08-01

Patients with epilepsy are often concerned that switching between brand-name and generic formulations of antiepilepsy drugs (AEDs) may cause clinically significant changes in plasma drug concentrations. We assessed bioequivalence (BE) studies for approved generic AEDs to evaluate US Food and Drug Administration claims that: (1) generic AEDs are accurate copies of reference formulations; (2) delivery of reference formulations may be as variable as generic AEDs and so provide no increased benefit; and (3) switches between generic AED formulations are safe and effective. We determined differences in 90% confidence interval limits for total drug exposure (AUC(0-t) ) and peak concentration (Cmax) ratios of generic and reference formulations during fasting and fed BE studies. We simulated BE between generic formulations after adjusting for reference values. AUC(0-t) values of approved reference and generic formulations differed by <15% in 99% of BE studies; Cmax differed by <15% in 89% of studies. Food affected variability of Cmax but not AUC(0-t) . Intersubject variability in Cmax and AUC(0-t) was small and similar for reference and generic products. In simulated switches between 595 pairs of generic AED formulations, estimated AUC(0-t) differed by >15% for 17% of pairs; estimated Cmax differed by >15% for 39%. AEDs with low bioavailability and solubility (eg, oxcarbazepine) had the greatest variability in BE. Most generic AED products provide total drug delivery (AUC) similar to reference products; differences in peak concentrations between formulations are more common. Switches between generic AED products may cause greater changes in plasma drug concentrations than generic substitutions of reference products. Copyright © 2011 American Neurological Association.

Fuzzy Logic Decoupled Longitudinal Control for General Aviation Airplanes

NASA Technical Reports Server (NTRS)

Duerksen, Noel

1996-01-01

It has been hypothesized that a human pilot uses the same set of generic skills to control a wide variety of aircraft. If this is true, then it should be possible to construct an electronic controller which embodies this generic skill set such that it can successfully control difference airplanes without being matched to a specific airplane. In an attempt to create such a system, a fuzzy logic controller was devised to control throttle position and another to control elevator position. These two controllers were used to control flight path angle and airspeed for both a piston powered single engine airplane simulation and a business jet simulation. Overspeed protection and stall protection were incorporated in the form of expert systems supervisors. It was found that by using the artificial intelligence techniques of fuzzy logic and expert systems, a generic longitudinal controller could be successfully used on two general aviation aircraft types that have very difference characteristics. These controllers worked for both airplanes over their entire flight envelopes including configuration changes. The controllers for both airplanes were identical except for airplane specific limits (maximum allowable airspeed, throttle lever travel, etc.). The controllers also handled configuration changes without mode switching or knowledge of the current configuration. This research validated the fact that the same fuzzy logic based controller can control two very different general aviation airplanes. It also developed the basic controller architecture and specific control parameters required for such a general controller.

Simulation system architecture design for generic communications link

NASA Technical Reports Server (NTRS)

Tsang, Chit-Sang; Ratliff, Jim

1986-01-01

This paper addresses a computer simulation system architecture design for generic digital communications systems. It addresses the issues of an overall system architecture in order to achieve a user-friendly, efficient, and yet easily implementable simulation system. The system block diagram and its individual functional components are described in detail. Software implementation is discussed with the VAX/VMS operating system used as a target environment.

Human life support during interplanetary travel and domicile. II - Generic Modular Flow Schematic modeling

NASA Technical Reports Server (NTRS)

Farral, Joseph F.; Seshan, P. K.; Rohatgi, Naresh K.

1991-01-01

This paper describes the Generic Modular Flow Schematic (GMFS) architecture capable of encompassing all functional elements of a physical/chemical life support system (LSS). The GMFS can be implemented to synthesize, model, analyze, and quantitatively compare many configurations of LSSs, from a simple, completely open-loop to a very complex closed-loop. The GMFS model is coded in ASPEN, a state-of-the-art chemical process simulation program, to accurately compute the material, heat, and power flow quantities for every stream in each of the subsystem functional elements (SFEs) in the chosen configuration of a life support system. The GMFS approach integrates the various SFEs and subsystems in a hierarchical and modular fashion facilitating rapid substitutions and reconfiguration of a life support system. The comprehensive ASPEN material and energy balance output is transferred to a systems and technology assessment spreadsheet for rigorous system analysis and trade studies.

Method for assigning sites to projected generic nuclear power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Holter, G.M.; Purcell, W.L.; Shutz, M.E.

1986-07-01

Pacific Northwest Laboratory developed a method for forecasting potential locations and startup sequences of nuclear power plants that will be required in the future but have not yet been specifically identified by electric utilities. Use of the method results in numerical ratings for potential nuclear power plant sites located in each of the 10 federal energy regions. The rating for each potential site is obtained from numerical factors assigned to each of 5 primary siting characteristics: (1) cooling water availability, (2) site land area, (3) power transmission land area, (4) proximity to metropolitan areas, and (5) utility plans for themore » site. The sequence of plant startups in each federal energy region is obtained by use of the numerical ratings and the forecasts of generic nuclear power plant startups obtained from the EIA Middle Case electricity forecast. Sites are assigned to generic plants in chronological order according to startup date.« less

78 FR 40729 - Agency Information Collection Activities; Proposed Collection; Comment Request: Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-08

... precision requirements or power calculations that justify the proposed sample size, the expected response... Qualitative Feedback on Agency Service Delivery AGENCY: Washington Headquarters Service (WHS), DOD. ACTION: 30... (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback on Agency Service Delivery...

Generic emergence of power law distributions and Lévy-Stable intermittent fluctuations in discrete logistic systems

NASA Astrophysics Data System (ADS)

Biham, Ofer; Malcai, Ofer; Levy, Moshe; Solomon, Sorin

1998-08-01

The dynamics of generic stochastic Lotka-Volterra (discrete logistic) systems of the form wi(t+1)=λ(t)wi(t)+aw¯(t)-bwi(t)w¯(t) is studied by computer simulations. The variables wi, i=1,...,N, are the individual system components and w¯(t)=(1/N)∑iwi(t) is their average. The parameters a and b are constants, while λ(t) is randomly chosen at each time step from a given distribution. Models of this type describe the temporal evolution of a large variety of systems such as stock markets and city populations. These systems are characterized by a large number of interacting objects and the dynamics is dominated by multiplicative processes. The instantaneous probability distribution P(w,t) of the system components wi turns out to fulfill a Pareto power law P(w,t)~w-1-α. The time evolution of w¯(t) presents intermittent fluctuations parametrized by a Lévy-stable distribution with the same index α, showing an intricate relation between the distribution of the wi's at a given time and the temporal fluctuations of their average.

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2011-06-28

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76 FR 13020 - Agency Information Collection Activities: Comment Request; Generic Clearance for the Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-09

... precision requirements or power calculations that justify the proposed sample size, the expected response... Clearance for the Collection of Qualitative Feedback on Agency Service Delivery AGENCY: Department of... Collection Request (Generic ICR): ``Generic Clearance for the Collection of Qualitative Feedback on Agency...

Cubature on Wiener Space: Pathwise Convergence

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayer, Christian, E-mail: christian.bayer@wias-berlin.de; Friz, Peter K., E-mail: friz@math.tu-berlin.de

2013-04-15

Cubature on Wiener space (Lyons and Victoir in Proc. R. Soc. Lond. A 460(2041):169-198, 2004) provides a powerful alternative to Monte Carlo simulation for the integration of certain functionals on Wiener space. More specifically, and in the language of mathematical finance, cubature allows for fast computation of European option prices in generic diffusion models.We give a random walk interpretation of cubature and similar (e.g. the Ninomiya-Victoir) weak approximation schemes. By using rough path analysis, we are able to establish weak convergence for general path-dependent option prices.

MIMO-OFDM System's Performance Using LDPC Codes for a Mobile Robot

NASA Astrophysics Data System (ADS)

Daoud, Omar; Alani, Omar

This work deals with the performance of a Sniffer Mobile Robot (SNFRbot)-based spatial multiplexed wireless Orthogonal Frequency Division Multiplexing (OFDM) transmission technology. The use of Multi-Input Multi-Output (MIMO)-OFDM technology increases the wireless transmission rate without increasing transmission power or bandwidth. A generic multilayer architecture of the SNFRbot is proposed with low power and low cost. Some experimental results are presented and show the efficiency of sniffing deadly gazes, sensing high temperatures and sending live videos of the monitored situation. Moreover, simulation results show the achieved performance by tackling the Peak-to-Average Power Ratio (PAPR) problem of the used technology using Low Density Parity Check (LDPC) codes; and the effect of combating the PAPR on the bit error rate (BER) and the signal to noise ratio (SNR) over a Doppler spread channel.

Force and Moment Approach for Achievable Dynamics Using Nonlinear Dynamic Inversion

NASA Technical Reports Server (NTRS)

Ostroff, Aaron J.; Bacon, Barton J.

1999-01-01

This paper describes a general form of nonlinear dynamic inversion control for use in a generic nonlinear simulation to evaluate candidate augmented aircraft dynamics. The implementation is specifically tailored to the task of quickly assessing an aircraft's control power requirements and defining the achievable dynamic set. The achievable set is evaluated while undergoing complex mission maneuvers, and perfect tracking will be accomplished when the desired dynamics are achievable. Variables are extracted directly from the simulation model each iteration, so robustness is not an issue. Included in this paper is a description of the implementation of the forces and moments from simulation variables, the calculation of control effectiveness coefficients, methods for implementing different types of aerodynamic and thrust vectoring controls, adjustments for control effector failures, and the allocation approach used. A few examples illustrate the perfect tracking results obtained.

Simulated procedure rehearsal is more effective than a preoperative generic warm-up for endovascular procedures.

PubMed

Willaert, Willem I M; Aggarwal, Rajesh; Daruwalla, Farhad; Van Herzeele, Isabelle; Darzi, Ara W; Vermassen, Frank E; Cheshire, Nicholas J

2012-06-01

Patient-specific simulated rehearsal (PsR) of a carotid artery stenting procedure (CAS) enables the interventionalist to rehearse the case before performing the procedure on the actual patient by incorporating patient-specific computed tomographic data into the simulation software. This study aimed to evaluate whether PsR of a CAS procedure can enhance the operative performance versus a virtual reality (VR) generic CAS warm-up procedure or no preparation at all. During a 10-session cognitive/technical VR course, medical residents were trained in CAS. Thereafter, in a randomized crossover study, each participant performed a patient-specific CAS case 3 times on the simulator, preceded by 3 different tasks: a PsR, a generic case, or no preparation. Technical performances were assessed using simulator-based metrics and expert-based ratings. Twenty medical residents (surgery, cardiology, radiology) were recruited. Training plateaus were observed after 10 sessions for all participants. Performances were significantly better after PsR than after a generic warm-up or no warm-up for total procedure time (16.3 ± 0.6 vs 19.7 ± 1.0 vs 20.9 ± 1.1 minutes, P = 0.001) and fluoroscopy time (9.3 ± 0.1 vs 11.2 ± 0.6 vs 11.2 ± 0.5 minutes, P = 0.022) but did not influence contrast volume or number of roadmaps used during the "real" case. PsR significantly improved the quality of performance as measured by the expert-based ratings (scores 28 vs 25 vs 25, P = 0.020). Patient-specific simulated rehearsal of a CAS procedure significantly improves operative performance, compared to a generic VR warm-up or no warm-up. This technology requires further investigation with respect to improved outcomes on patients in the clinical setting.

The SENSEI Generic In Situ Interface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ayachit, Utkarsh; Whitlock, Brad; Wolf, Matthew

The SENSEI generic in situ interface is an API that promotes code portability and reusability. From the simulation view, a developer can instrument their code with the SENSEI API and then make make use of any number of in situ infrastructures. From the method view, a developer can write an in situ method using the SENSEI API, then expect it to run in any number of in situ infrastructures, or be invoked directly from a simulation code, with little or no modification. This paper presents the design principles underlying the SENSEI generic interface, along with some simplified coding examples.

Rocketdyne/Westinghouse nuclear thermal rocket engine modeling

NASA Technical Reports Server (NTRS)

Glass, James F.

1993-01-01

The topics are presented in viewgraph form and include the following: systems approach needed for nuclear thermal rocket (NTR) design optimization; generic NTR engine power balance codes; rocketdyne nuclear thermal system code; software capabilities; steady state model; NTR engine optimizer code-logic; reactor power calculation logic; sample multi-component configuration; NTR design code output; generic NTR code at Rocketdyne; Rocketdyne NTR model; and nuclear thermal rocket modeling directions.

A Generic Inner-Loop Control Law Structure for Six-Degree-of-Freedom Conceptual Aircraft Design

NASA Technical Reports Server (NTRS)

Cox, Timothy H.; Cotting, M. Christopher

2005-01-01

A generic control system framework for both real-time and batch six-degree-of-freedom simulations is presented. This framework uses a simplified dynamic inversion technique to allow for stabilization and control of any type of aircraft at the pilot interface level. The simulation, designed primarily for the real-time simulation environment, also can be run in a batch mode through a simple guidance interface. Direct vehicle-state acceleration feedback is required with the simplified dynamic inversion technique. The estimation of surface effectiveness within real-time simulation timing constraints also is required. The generic framework provides easily modifiable control variables, allowing flexibility in the variables that the pilot commands. A direct control allocation scheme is used to command aircraft effectors. Primary uses for this system include conceptual and preliminary design of aircraft, when vehicle models are rapidly changing and knowledge of vehicle six-degree-of-freedom performance is required. A simulated airbreathing hypersonic vehicle and simulated high-performance fighter aircraft are used to demonstrate the flexibility and utility of the control system.

A Generic Inner-Loop Control Law Structure for Six-Degree-of-Freedom Conceptual Aircraft Design

NASA Technical Reports Server (NTRS)

Cox, Timothy H.; Cotting, Christopher

2005-01-01

A generic control system framework for both real-time and batch six-degree-of-freedom (6-DOF) simulations is presented. This framework uses a simplified dynamic inversion technique to allow for stabilization and control of any type of aircraft at the pilot interface level. The simulation, designed primarily for the real-time simulation environment, also can be run in a batch mode through a simple guidance interface. Direct vehicle-state acceleration feedback is required with the simplified dynamic inversion technique. The estimation of surface effectiveness within real-time simulation timing constraints also is required. The generic framework provides easily modifiable control variables, allowing flexibility in the variables that the pilot commands. A direct control allocation scheme is used to command aircraft effectors. Primary uses for this system include conceptual and preliminary design of aircraft, when vehicle models are rapidly changing and knowledge of vehicle 6-DOF performance is required. A simulated airbreathing hypersonic vehicle and simulated high-performance fighter aircraft are used to demonstrate the flexibility and utility of the control system.

Automating Embedded Analysis Capabilities and Managing Software Complexity in Multiphysics Simulation, Part I: Template-Based Generic Programming

DOE PAGES

Pawlowski, Roger P.; Phipps, Eric T.; Salinger, Andrew G.

2012-01-01

An approach for incorporating embedded simulation and analysis capabilities in complex simulation codes through template-based generic programming is presented. This approach relies on templating and operator overloading within the C++ language to transform a given calculation into one that can compute a variety of additional quantities that are necessary for many state-of-the-art simulation and analysis algorithms. An approach for incorporating these ideas into complex simulation codes through general graph-based assembly is also presented. These ideas have been implemented within a set of packages in the Trilinos framework and are demonstrated on a simple problem from chemical engineering.

Maximum wind energy extraction strategies using power electronic converters

NASA Astrophysics Data System (ADS)

Wang, Quincy Qing

2003-10-01

This thesis focuses on maximum wind energy extraction strategies for achieving the highest energy output of variable speed wind turbine power generation systems. Power electronic converters and controls provide the basic platform to accomplish the research of this thesis in both hardware and software aspects. In order to send wind energy to a utility grid, a variable speed wind turbine requires a power electronic converter to convert a variable voltage variable frequency source into a fixed voltage fixed frequency supply. Generic single-phase and three-phase converter topologies, converter control methods for wind power generation, as well as the developed direct drive generator, are introduced in the thesis for establishing variable-speed wind energy conversion systems. Variable speed wind power generation system modeling and simulation are essential methods both for understanding the system behavior and for developing advanced system control strategies. Wind generation system components, including wind turbine, 1-phase IGBT inverter, 3-phase IGBT inverter, synchronous generator, and rectifier, are modeled in this thesis using MATLAB/SIMULINK. The simulation results have been verified by a commercial simulation software package, PSIM, and confirmed by field test results. Since the dynamic time constants for these individual models are much different, a creative approach has also been developed in this thesis to combine these models for entire wind power generation system simulation. An advanced maximum wind energy extraction strategy relies not only on proper system hardware design, but also on sophisticated software control algorithms. Based on literature review and computer simulation on wind turbine control algorithms, an intelligent maximum wind energy extraction control algorithm is proposed in this thesis. This algorithm has a unique on-line adaptation and optimization capability, which is able to achieve maximum wind energy conversion efficiency through continuously improving the performance of wind power generation systems. This algorithm is independent of wind power generation system characteristics, and does not need wind speed and turbine speed measurements. Therefore, it can be easily implemented into various wind energy generation systems with different turbine inertia and diverse system hardware environments. In addition to the detailed description of the proposed algorithm, computer simulation results are presented in the thesis to demonstrate the advantage of this algorithm. As a final confirmation of the algorithm feasibility, the algorithm has been implemented inside a single-phase IGBT inverter, and tested with a wind simulator system in research laboratory. Test results were found consistent with the simulation results. (Abstract shortened by UMI.)

Modular Aero-Propulsion System Simulation

NASA Technical Reports Server (NTRS)

Parker, Khary I.; Guo, Ten-Huei

2006-01-01

The Modular Aero-Propulsion System Simulation (MAPSS) is a graphical simulation environment designed for the development of advanced control algorithms and rapid testing of these algorithms on a generic computational model of a turbofan engine and its control system. MAPSS is a nonlinear, non-real-time simulation comprising a Component Level Model (CLM) module and a Controller-and-Actuator Dynamics (CAD) module. The CLM module simulates the dynamics of engine components at a sampling rate of 2,500 Hz. The controller submodule of the CAD module simulates a digital controller, which has a typical update rate of 50 Hz. The sampling rate for the actuators in the CAD module is the same as that of the CLM. MAPSS provides a graphical user interface that affords easy access to engine-operation, engine-health, and control parameters; is used to enter such input model parameters as power lever angle (PLA), Mach number, and altitude; and can be used to change controller and engine parameters. Output variables are selectable by the user. Output data as well as any changes to constants and other parameters can be saved and reloaded into the GUI later.

Broadband rectangular TEn0 mode exciter with H-plane power dividers for 100 GHz confocal gyro-devices.

PubMed

Yao, Yelei; Wang, Jianxun; Li, Hao; Liu, Guo; Luo, Yong

2017-07-01

A generic approach to excite TE n0 (n ≥ 1) modes in a rectangular waveguide for confocal gyro-devices is proposed. The exciter consists of a 3 dB H-plane power divider (n ≥ 3) and a mode-converting section. The injection power is split into two in-phase signals with equal amplitudes which simultaneously excite the secondary waveguide via two sets of multiple slots. Both the position and width of the slot are symmetrically distributed with respect to the center line for each set of slots. The slot width complies with a geometry sequence, with adjacent slots being spaced a quarter wavelength apart to cancel the backward wave out. A TE 40 mode exciter at 100 GHz is numerically simulated and optimized, achieving a 1 dB and a 3 dB transmission bandwidth of 18.2 and 21 GHz, respectively. The prototype is fabricated and measured. The cold test is carried out utilizing two identical back-to-back connected mode exciters, and the measured performances are in good agreement with the numerical simulation results when taking into account the wall loss and assembly tolerance.

Simulating the spread of malaria using a generic transmission model for mosquito-borne infectious diseases

NASA Astrophysics Data System (ADS)

Kon, Cynthia Mui Lian; Labadin, Jane

2016-06-01

Malaria is a critical infection caused by parasites which are spread to humans through mosquito bites. Approximately half of the world's population is in peril of getting infected by malaria. Mosquito-borne diseases have a standard behavior where they are transmitted in the same manner, only through vector mosquito. Taking this into account, a generic spatial-temporal model for transmission of multiple mosquito-borne diseases had been formulated. Our interest is to reproduce the actual cases of different mosquito-borne diseases using the generic model and then predict future cases so as to improve control and target measures competently. In this paper, we utilize notified weekly malaria cases in four districts in Sarawak, Malaysia, namely Kapit, Song, Belaga and Marudi. The actual cases for 36 weeks, which is from week 39 in 2012 to week 22 in 2013, are compared with simulations of the generic spatial-temporal transmission mosquito-borne diseases model. We observe that the simulation results display corresponding result to the actual malaria cases in the four districts.

Piloted simulation study of the effects of an automated trim system on flight characteristics of a light twin-engine airplane with one engine inoperative

NASA Technical Reports Server (NTRS)

Stewart, E. C.; Brown, P. W.; Yenni, K. R.

1986-01-01

A simulation study was conducted to investigate the piloting problems associated with failure of an engine on a generic light twin-engine airplane. A primary piloting problem for a light twin-engine airplane after an engine failure is maintaining precise control of the airplane in the presence of large steady control forces. To address this problem, a simulated automatic trim system which drives the trim tabs as an open-loop function of propeller slipstream measurements was developed. The simulated automatic trim system was found to greatly increase the controllability in asymmetric powered flight without having to resort to complex control laws or an irreversible control system. However, the trim-tab control rates needed to produce the dramatic increase in controllability may require special design consideration for automatic trim system failures. Limited measurements obtained in full-scale flight tests confirmed the fundamental validity of the proposed control law.

Sensitivity of estimated muscle force in forward simulation of normal walking

PubMed Central

Xiao, Ming; Higginson, Jill

2009-01-01

Generic muscle parameters are often used in muscle-driven simulations of human movement estimate individual muscle forces and function. The results may not be valid since muscle properties vary from subject to subject. This study investigated the effect of using generic parameters in a muscle-driven forward simulation on muscle force estimation. We generated a normal walking simulation in OpenSim and examined the sensitivity of individual muscle to perturbations in muscle parameters, including the number of muscles, maximum isometric force, optimal fiber length and tendon slack length. We found that when changing the number muscles included in the model, only magnitude of the estimated muscle forces was affected. Our results also suggest it is especially important to use accurate values of tendon slack length and optimal fiber length for ankle plantarflexors and knee extensors. Changes in force production one muscle were typically compensated for by changes in force production by muscles in the same functional muscle group, or the antagonistic muscle group. Conclusions regarding muscle function based on simulations with generic musculoskeletal parameters should be interpreted with caution. PMID:20498485

An intelligent simulation training system

NASA Technical Reports Server (NTRS)

Biegel, John E.

1990-01-01

The Department of Industrial Engineering at the University of Central Florida, Embry-Riddle Aeronautical University and General Electric (SCSD) have been funded by the State of Florida to build an Intelligent Simulation Training System. The objective was and is to make the system generic except for the domain expertise. Researchers accomplished this objective in their prototype. The system is modularized and therefore it is easy to make any corrections, expansions or adaptations. The funding by the state of Florida has exceeded $3 million over the past three years and through the 1990 fiscal year. UCF has expended in excess of 15 work years on the project. The project effort has been broken into three major tasks. General Electric provides the simulation. Embry-Riddle Aeronautical University provides the domain expertise. The University of Central Florida has constructed the generic part of the system which is comprised of several modules that perform the tutoring, evaluation, communication, status, etc. The generic parts of the Intelligent Simulation Training Systems (ISTS) are described.

SmartSIM - a virtual reality simulator for laparoscopy training using a generic physics engine.

PubMed

Khan, Zohaib Amjad; Kamal, Nabeel; Hameed, Asad; Mahmood, Amama; Zainab, Rida; Sadia, Bushra; Mansoor, Shamyl Bin; Hasan, Osman

2017-09-01

Virtual reality (VR) training simulators have started playing a vital role in enhancing surgical skills, such as hand-eye coordination in laparoscopy, and practicing surgical scenarios that cannot be easily created using physical models. We describe a new VR simulator for basic training in laparoscopy, i.e. SmartSIM, which has been developed using a generic open-source physics engine called the simulation open framework architecture (SOFA). This paper describes the systems perspective of SmartSIM including design details of both hardware and software components, while highlighting the critical design decisions. Some of the distinguishing features of SmartSIM include: (i) an easy-to-fabricate custom-built hardware interface; (ii) use of a generic physics engine to facilitate wider accessibility of our work and flexibility in terms of using various graphical modelling algorithms and their implementations; and (iii) an intelligent and smart evaluation mechanism that facilitates unsupervised and independent learning. Copyright © 2016 John Wiley & Sons, Ltd.

Stress-strain analysis of a (0/90)sub 2 symmetric titanium matrix laminate subjected to a generic hypersonic flight profile

NASA Technical Reports Server (NTRS)

Mirdamadi, Massoud; Johnson, W. Steven

1992-01-01

Cross ply laminate behavior of Ti-15V-3Cr-3Al-3Sn (Ti-15-3) matrix reinforced with continuous silicon carbide fibers (SCS-6) subjected to a generic hypersonic flight profile was evaluated experimentally and analytically. Thermomechanical fatigue test techniques were developed to conduct a simulation of a generic hypersonic flight profile. A micromechanical analysis was used. The analysis predicts the stress-strain response of the laminate and of the constituents in each ply during thermal and mechanical cycling by using only constituent properties as input. The fiber was modeled using a thermo-viscoplastic constitutive relation. The fiber transverse modulus was reduced in the analysis to simulate the fiber matrix interface failure. Excellent correlation was found between measured and predicted laminate stress-strain response due to generic hypersonic flight profile when fiber debonding was modeled.

Extending the Operational Envelope of a Turbofan Engine Simulation into the Sub-Idle Region

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Hamley, Andrew J.; Guo, Ten-Huei; Litt, Jonathan S.

2016-01-01

In many non-linear gas turbine simulations, operation in the sub-idle region can lead to model instability. This paper lays out a method for extending the operational envelope of a map based gas turbine simulation to include the sub-idle region. This method develops a multi-simulation solution where the baseline component maps are extrapolated below the idle level and an alternate model is developed to serve as a safety net when the baseline model becomes unstable or unreliable. Sub-idle model development takes place in two distinct operational areas, windmilling/shutdown and purge/cranking/ startup. These models are based on derived steady state operating points with transient values extrapolated between initial (known) and final (assumed) states. Model transitioning logic is developed to predict baseline model sub-idle instability, and transition smoothly and stably to the backup sub-idle model. Results from the simulation show a realistic approximation of sub-idle behavior as compared to generic sub-idle engine performance that allows the engine to operate continuously and stably from shutdown to full power.

Extending the Operational Envelope of a Turbofan Engine Simulation into the Sub-Idle Region

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes Walter; Hamley, Andrew J.; Guo, Ten-Huei; Litt, Jonathan S.

2016-01-01

In many non-linear gas turbine simulations, operation in the sub-idle region can lead to model instability. This paper lays out a method for extending the operational envelope of a map based gas turbine simulation to include the sub-idle region. This method develops a multi-simulation solution where the baseline component maps are extrapolated below the idle level and an alternate model is developed to serve as a safety net when the baseline model becomes unstable or unreliable. Sub-idle model development takes place in two distinct operational areas, windmilling/shutdown and purge/cranking/startup. These models are based on derived steady state operating points with transient values extrapolated between initial (known) and final (assumed) states. Model transitioning logic is developed to predict baseline model sub-idle instability, and transition smoothly and stably to the backup sub-idle model. Results from the simulation show a realistic approximation of sub-idle behavior as compared to generic sub-idle engine performance that allows the engine to operate continuously and stably from shutdown to full power.

Generic hierarchical engine for mask data preparation

NASA Astrophysics Data System (ADS)

Kalus, Christian K.; Roessl, Wolfgang; Schnitker, Uwe; Simecek, Michal

2002-07-01

Electronic layouts are usually flattened on their path from the hierarchical source downstream to the wafer. Mask data preparation has certainly been identified as a severe bottleneck since long. Data volumes are not only doubling every year along the ITRS roadmap. With the advent of optical proximity correction and phase-shifting masks data volumes are escalating up to non-manageable heights. Hierarchical treatment is one of the most powerful means to keep memory and CPU consumption in reasonable ranges. Only recently, however, has this technique acquired more public attention. Mask data preparation is the most critical area calling for a sound infrastructure to reduce the handling problem. Gaining more and more attention though, are other applications such as large area simulation and manufacturing rule checking (MRC). They all would profit from a generic engine capable to efficiently treat hierarchical data. In this paper we will present a generic engine for hierarchical treatment which solves the major problem, steady transitions along cell borders. Several alternatives exist how to walk through the hierarchy tree. They have, to date, not been thoroughly investigated. One is a bottom-up attempt to treat cells starting with the most elementary cells. The other one is a top-down approach which lends itself to creating a new hierarchy tree. In addition, since the variety, degree of hierarchy and quality of layouts extends over a wide range a generic engine has to take intelligent decisions when exploding the hierarchy tree. Several applications will be shown, in particular how far the limits can be pushed with the current hierarchical engine.

An integrated development framework for rapid development of platform-independent and reusable satellite on-board software

NASA Astrophysics Data System (ADS)

Ziemke, Claas; Kuwahara, Toshinori; Kossev, Ivan

2011-09-01

Even in the field of small satellites, the on-board data handling subsystem has become complex and powerful. With the introduction of powerful CPUs and the availability of considerable amounts of memory on-board a small satellite it has become possible to utilize the flexibility and power of contemporary platform-independent real-time operating systems. Especially the non-commercial sector such like university institutes and community projects such as AMSAT or SSETI are characterized by the inherent lack of financial as well as manpower resources. The opportunity to utilize such real-time operating systems will contribute significantly to achieve a successful mission. Nevertheless the on-board software of a satellite is much more than just an operating system. It has to fulfill a multitude of functional requirements such as: Telecommand interpretation and execution, execution of control loops, generation of telemetry data and frames, failure detection isolation and recovery, the communication with peripherals and so on. Most of the aforementioned tasks are of generic nature and have to be conducted on any satellite with only minor modifications. A general set of functional requirements as well as a protocol for communication is defined in the SA ECSS-E-70-41A standard "Telemetry and telecommand packet utilization". This standard not only defines the communication protocol of the satellite-ground link but also defines a set of so called services which have to be available on-board of every compliant satellite and which are of generic nature. In this paper, a platform-independent and reusable framework is described which is implementing not only the ECSS-E-70-41A standard but also functionalities for interprocess communication, scheduling and a multitude of tasks commonly performed on-board of a satellite. By making use of the capabilities of the high-level programming language C/C++, the powerful open source library BOOST, the real-time operating system RTEMS and finally by providing generic functionalities compliant to the ECSS-E-70-41A standard the proposed framework can provide a great boost in productivity. Together with open source tools such like the GNU tool-chain, Eclipse SDK, the simulation framework OpenSimKit, the emulator QEMU, the proposed on-board software framework forms an integrated development framework. It is possible to design, code and build the on-board software together with the operating system and then run it on a simulated satellite for performance analysis and debugging purposes. This makes it possible to rapidly develop and deploy a full-fledged satellite on-board software with minimal cost and in a limited time frame.

On assessing bioequivalence and interchangeability between generics based on indirect comparisons.

PubMed

Zheng, Jiayin; Chow, Shein-Chung; Yuan, Mengdie

2017-08-30

As more and more generics become available in the market place, the safety/efficacy concerns may arise as the result of interchangeably use of approved generics. However, bioequivalence assessment for regulatory approval among generics of the innovative drug product is not required. In practice, approved generics are often used interchangeably without any mechanism of safety monitoring. In this article, based on indirect comparisons, we proposed several methods to assessing bioequivalence and interchangeability between generics. The applicability of the methods and the similarity assumptions were discussed, as well as the inappropriateness of directly adopting adjusted indirect comparison to the field of generics' comparison. Besides, some extensions were given to take into consideration the important topics in clinical trials for bioequivalence assessments, for example, multiple comparisons and simultaneously testing bioequivalence among three generics. Extensive simulation studies were conducted to investigate the performances of the proposed methods. The studies of malaria generics and HIV/AIDS generics prequalified by the WHO were used as real examples to demonstrate the use of the methods. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Strut and wall interference on jet-induced ground effects of a STOVL aircraft in hover

NASA Technical Reports Server (NTRS)

Kristy, Michael H.

1995-01-01

A small scale ground effect test rig was used to study the ground plane flow field generated by a STOVL aircraft in hover. The objective of the research was to support NASA-Ames Research Center planning for the Large Scale Powered Model (LSPM) test for the ARPA-sponsored ASTOVL program. Specifically, small scale oil flow visualization studies were conducted to make a relative assessment of the aerodynamic interference of a proposed strut configuration and a wall configuration on the ground plane stagnation line. A simplified flat plate model representative of a generic jet-powered STOVL aircraft was used to simulate the LSPM. Cold air jets were used to simulate both the lift fan and the twin rear engines. Nozzle Pressure Ratios were used that closely represented those used on the LSPM tests. The flow visualization data clearly identified a shift in the stagnation line location for both the strut and the wall configuration. Considering the experimental uncertainty, it was concluded that either the strut configuration o r the wall configuration caused only a minor aerodynamic interference.

Implementation and Evaluation of Multiple Adaptive Control Technologies for a Generic Transport Aircraft Simulation

NASA Technical Reports Server (NTRS)

Campbell, Stefan F.; Kaneshige, John T.; Nguyen, Nhan T.; Krishakumar, Kalmanje S.

2010-01-01

Presented here is the evaluation of multiple adaptive control technologies for a generic transport aircraft simulation. For this study, seven model reference adaptive control (MRAC) based technologies were considered. Each technology was integrated into an identical dynamic-inversion control architecture and tuned using a methodology based on metrics and specific design requirements. Simulation tests were then performed to evaluate each technology s sensitivity to time-delay, flight condition, model uncertainty, and artificially induced cross-coupling. The resulting robustness and performance characteristics were used to identify potential strengths, weaknesses, and integration challenges of the individual adaptive control technologies

(abstract) Generic Modeling of a Life Support System for Process Technology Comparisons

NASA Technical Reports Server (NTRS)

Ferrall, J. F.; Seshan, P. K.; Rohatgi, N. K.; Ganapathi, G. B.

1993-01-01

This paper describes a simulation model called the Life Support Systems Analysis Simulation Tool (LiSSA-ST), the spreadsheet program called the Life Support Systems Analysis Trade Tool (LiSSA-TT), and the Generic Modular Flow Schematic (GMFS) modeling technique. Results of using the LiSSA-ST and the LiSSA-TT will be presented for comparing life support systems and process technology options for a Lunar Base and a Mars Exploration Mission.

Intrinsically Disordered Protein Specific Force Field CHARMM36IDPSFF.

PubMed

Liu, Hao; Song, Dong; Lu, Hui; Luo, Ray; Chen, Hai-Feng

2018-05-28

Intrinsically disordered proteins (IDPs) are closely related to various human diseases. Because IDPs lack certain tertiary structure, it is difficult to use X-ray and NMR methods to measure their structures. Therefore, molecular dynamics simulation is a useful tool to study the conformer distribution of IDPs. However, most generic protein force fields were found to be insufficient in simulations of IDPs. Here we report our development for the CHARMM community. Our residue-specific IDP force field (CHARMM36IDPSFF) was developed based on the base generic force field with CMAP corrections of for all 20 naturally occurring amino acids. Multiple tests show that the simulated chemical shifts with the newly developed force field are in quantitative agreement with NMR experiment and are more accurate than the base generic force field. Comparison of J-couplings with previous work shows that CHARMM36IDPSFF and its corresponding base generic force field have their own advantages. In addition, CHARMM36IDPSFF simulations also agree with experiment for SAXS profiles and radii of gyration of IDPs. Detailed analysis shows that CHARMM36IDPSFF can sample more diverse and disordered conformers. These findings confirm that the newly developed force field can improve the balance of accuracy and efficiency for the conformer sampling of IDPs. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

A Close Loop Low-Power and High Speed 130 nm CMOS Sample and Hold Circuit Based on Switched Capacitor for ADC Module

NASA Astrophysics Data System (ADS)

Nasir, Z.; Ruslan, S. H.

2017-08-01

A sample and hold (S/H) block is typically used as an analogue to digital interface in the analogue to digital converter (ADC) system. Since ADC is widely used in processing signals, the power consumption of the ADC must be lowered to conserve energy. Therefore the S/H circuit must be of a low powered too. Sampling phase and hold phase are the two phases of the operation cycle of the S/H circuit. Switched capacitor (SC) techniques have been developed in order to allow the integration on a single silicon chip of both digital and analogue functions. By controlling switches around the SC, the SC circuit works by passing charge into and out of a capacitor. SC circuits are suitable for on chip implementations because they replace a resistor with switches and capacitors. In this research, a closed-loop sample and hold circuit based on SC is designed and simulated with Cadence EDA tools. The schematic, layout, and simulation of the circuit is done using generic Silterra 130 nm technology file. All the analysis is done using Virtuoso Analog Design Environment. Layout and schematic are drawn using Virtuoso Schematic Editor and Virtuoso Layout Editor, Calibre is used for post layout simulation. The closed loop S/H circuit based on SC is successfully designed and able to sample and hold the analogue input waveform. The power consumption of the circuit is 0.919 mW and the propagation delay is 64.96 ps.

Space platform utilities distribution study

NASA Technical Reports Server (NTRS)

Lefever, A. E.

1980-01-01

Generic concepts for the installation of power data and thermal fluid distribution lines on large space platforms were discussed. Connections with central utility subsystem modules and pallet interfaces were also considered. Three system concept study platforms were used as basepoints for the detail development. The tradeoff of high voltage low voltage power distribution and the impact of fiber optics as a data distribution mechanism were analyzed. Thermal expansion and temperature control of utility lines and ducts were considered. Technology developments required for implementation of the generic distribution concepts were identified.

Impacts of supersymmetric higher derivative terms on inflation models in supergravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aoki, Shuntaro; Yamada, Yusuke, E-mail: shun-soccer@akane.waseda.jp, E-mail: yuusuke-yamada@asagi.waseda.jp

2015-07-01

We show the effects of supersymmetric higher derivative terms on inflation models in supergravity. The results show that such terms generically modify the effective kinetic coefficient of the inflaton during inflation if the cut off scale of the higher derivative operators is sufficiently small. In such a case, the η-problem in supergravity does not occur, and we find that the effective potential of the inflaton generically becomes a power type potential with a power smaller than two.

Large-Scale Simulations of Plastic Neural Networks on Neuromorphic Hardware

PubMed Central

Knight, James C.; Tully, Philip J.; Kaplan, Bernhard A.; Lansner, Anders; Furber, Steve B.

2016-01-01

SpiNNaker is a digital, neuromorphic architecture designed for simulating large-scale spiking neural networks at speeds close to biological real-time. Rather than using bespoke analog or digital hardware, the basic computational unit of a SpiNNaker system is a general-purpose ARM processor, allowing it to be programmed to simulate a wide variety of neuron and synapse models. This flexibility is particularly valuable in the study of biological plasticity phenomena. A recently proposed learning rule based on the Bayesian Confidence Propagation Neural Network (BCPNN) paradigm offers a generic framework for modeling the interaction of different plasticity mechanisms using spiking neurons. However, it can be computationally expensive to simulate large networks with BCPNN learning since it requires multiple state variables for each synapse, each of which needs to be updated every simulation time-step. We discuss the trade-offs in efficiency and accuracy involved in developing an event-based BCPNN implementation for SpiNNaker based on an analytical solution to the BCPNN equations, and detail the steps taken to fit this within the limited computational and memory resources of the SpiNNaker architecture. We demonstrate this learning rule by learning temporal sequences of neural activity within a recurrent attractor network which we simulate at scales of up to 2.0 × 104 neurons and 5.1 × 107 plastic synapses: the largest plastic neural network ever to be simulated on neuromorphic hardware. We also run a comparable simulation on a Cray XC-30 supercomputer system and find that, if it is to match the run-time of our SpiNNaker simulation, the super computer system uses approximately 45× more power. This suggests that cheaper, more power efficient neuromorphic systems are becoming useful discovery tools in the study of plasticity in large-scale brain models. PMID:27092061

Generic substitution: micro evidence from register data in Norway.

PubMed

Dalen, Dag Morten; Furu, Kari; Locatelli, Marilena; Strøm, Steinar

2011-02-01

The importance of prices, doctor and patient characteristics, and market institutions for the likelihood of choosing generic drugs instead of the more expensive original brand-name version are examined. Using an extensive dataset extracted from The Norwegian Prescription Database containing all prescriptions dispensed to individuals in February 2004 and 2006 on 23 different drugs (chemical substances) in Norway, we find strong evidence for the importance of both doctor and patient characteristics for the choice probabilities. The price difference between brand and generic versions and insurance coverage both affect generic substitution. Moreover, controlling for the retail chain affiliation of the dispensing pharmacy, we find that pharmacies play an important role in promoting generic substitution. In markets with more recent entry of generic drugs, brand-name loyalty proves to be much stronger, giving less explanatory power to our demand model.

Single-trabecula building block for large-scale finite element models of cancellous bone.

PubMed

Dagan, D; Be'ery, M; Gefen, A

2004-07-01

Recent development of high-resolution imaging of cancellous bone allows finite element (FE) analysis of bone tissue stresses and strains in individual trabeculae. However, specimen-specific stress/strain analyses can include effects of anatomical variations and local damage that can bias the interpretation of the results from individual specimens with respect to large populations. This study developed a standard (generic) 'building-block' of a trabecula for large-scale FE models. Being parametric and based on statistics of dimensions of ovine trabeculae, this building block can be scaled for trabecular thickness and length and be used in commercial or custom-made FE codes to construct generic, large-scale FE models of bone, using less computer power than that currently required to reproduce the accurate micro-architecture of trabecular bone. Orthogonal lattices constructed with this building block, after it was scaled to trabeculae of the human proximal femur, provided apparent elastic moduli of approximately 150 MPa, in good agreement with experimental data for the stiffness of cancellous bone from this site. Likewise, lattices with thinner, osteoporotic-like trabeculae could predict a reduction of approximately 30% in the apparent elastic modulus, as reported in experimental studies of osteoporotic femora. Based on these comparisons, it is concluded that the single-trabecula element developed in the present study is well-suited for representing cancellous bone in large-scale generic FE simulations.

Modelling Wireless Power Transfer Using an Array of Tesla Coils

NASA Astrophysics Data System (ADS)

Pierson, Casey Thomas

Wireless power transmission, or WPT, is a well-demonstrated property in electrical science and physics. Coil-and-wave transmission (CWT) consists of two Tesla coils, one powered by a controlled voltage source v src and one connected across a generic load Z 0 , at a mid- to long range distance apart with spherical capacitors at each of their top loads. The literature on the different methods of WPT varies widely, but research of CWT is sparse, lacking especially in the area of computer simulation. Recently, a physical experiment was conducted by Marzolf et al. in [1], and yielded surprising resonant frequencies in the high frequency range. The goal of this research is to answer the question of whether these reosnant frequencies originate in unexplained field effects or in non-ideal circuit behavior, and establish a formal model to indicate at what frequencies the resonant peaks occur as a first approximation. By carefully constructing a simulation of the most geometrically simple, power efficient design in the work of Marzolf et al. using the scientific software Octave, we investigate these frequencies computationally: first, an ideal scenario that has no flux leakage or exterior losses is modelled mathematically and simulated, and then, a non-ideal scenario that accounts for losses in the coils and surroundings is modelled mathematically and simulated. Both models utilize a simple formula for spherical capacitance for the top loads. After running these simulations through detailed sampling up to 4 MHz, the ideal model could not account for the resonant peaks, while the non-ideal model indicated the resonant peaks near the exact frequency ranges that were observed. An unexpected characteristic of these results was that coupling coefficients between the coils of the transmitter and receiver played a noticeable part in the indication of resonant peaks. This demonstrates that unknown field effects are not the primary driver of resonance in the ideal or non-ideal construction, and raises inriguing questions about the circuit design's relationship with resonance in the locality about the coils.

Energy Fluctuation of Ideal Fermi Gas Trapped under Generic Power Law Potential U=\\sum_{i=1}^{d} c_i\\vert x_{i}/a_{i}\\vert^{n_{i} } in d Dimensions

NASA Astrophysics Data System (ADS)

Mir, Mehedi Faruk; Muktadir Rahman, Md.; Dwaipayan, Debnath; Sakhawat Hossain Himel, Md.

2016-04-01

Energy fluctuation of ideal Fermi gas trapped under generic power law potential U=\\sumi=1d ci \\vertxi/ai \\vert n_i has been calculated in arbitrary dimensions. Energy fluctuation is scrutinized further in the degenerate limit μ ≫ KBT with the help of Sommerfeld expansion. The dependence of energy fluctuation on dimensionality and power law potential is studied in detail. Most importantly our general result can not only exactly reproduce the recently published result regarding free and harmonically trapped ideal Fermi gas in d = 3 but also can describe the outcome for any power law potential in arbitrary dimension.

Performance degradation of a model helicopter rotor with a generic ice shape

NASA Technical Reports Server (NTRS)

Korkan, K. D.; Cross, E. J., Jr.; Miller, T. L.

1984-01-01

An experimental program using a commercially available remotely controlled model helicopter in the Texas A&M University (TAMU) subsonic wind tunnel has been conducted to investigate the performance degradation resulting from the simulated formation of ice on the leading edge of the main rotor blades in both hover and forward flight. The rotor blades utilized a NACA 0012 airfoil with a 2.5-in. constant chord. A generic ice shape derived from a predetermined natural ice condition was applied to the 53.375-in.-diameter main rotor, and thrust and torque coefficients were measured for the main rotor as functions of velocity, main rotor rpm, fuselage angle of incidence, collective pitch angle, and spanwise extent of icing. The model helicopter test exhibited significant performance degradation of the main rotor when generic ice was added. An increase of approximately 150 percent in torque coefficient to maintain a constant thrust coefficient was noted when generic ice had been applied to the 85 percent rotor radial location. Also, considerable additional degradation occurred when generic ice was applied to the 100 percent rotor radial location, as compared with the 85 percent simulated ice performance values, indicating the sensitivity of the rotor tip region.

Overview of NASA Lewis Research Center free-piston Stirling engine activities

NASA Technical Reports Server (NTRS)

Slaby, J. G.

1984-01-01

A generic free-piston Stirling technology project is being conducted to develop technologies generic to both space power and terrestrial heat pump applications in a cooperative, cost-shared effort. The generic technology effort includes extensive parametric testing of a 1 kW free-piston Stirling engine (RE-1000), development of a free-piston Stirling performance computer code, design and fabrication under contract of a hydraulic output modification for RE-1000 engine tests, and a 1000-hour endurance test, under contract, of a 3 kWe free-piston Stirling/alternator engine. A newly initiated space power technology feasibility demonstration effort addresses the capability of scaling a free-piston Stirling/alternator system to about 25 kWe; developing thermodynamic cycle efficiency or equal to 70 percent of Carnot at temperature ratios in the order of 1.5 to 2.0; achieving a power conversion unit specific weight of 6 kg/kWe; operating with noncontacting gas bearings; and dynamically balancing the system. Planned engine and component design and test efforts are described.

How should we build a generic open-source water management simulator?

NASA Astrophysics Data System (ADS)

Khadem, M.; Meier, P.; Rheinheimer, D. E.; Padula, S.; Matrosov, E.; Selby, P. D.; Knox, S.; Harou, J. J.

2014-12-01

Increasing water needs for agriculture, industry and cities mean effective and flexible water resource system management tools will remain in high demand. Currently many regions or countries use simulators that have been adapted over time to their unique system properties and water management rules and realities. Most regions operate with a preferred short-list of water management and planning decision support systems. Is there scope for a simulator, shared within the water management community, that could be adapted to different contexts, integrate community contributions, and connect to generic data and model management software? What role could open-source play in such a project? How could a genericuser-interface and data/model management software sustainably be attached to this model or suite of models? Finally, how could such a system effectively leverage existing model formulations, modeling technologies and software? These questions are addressed by the initial work presented here. We introduce a generic water resource simulation formulation that enables and integrates both rule-based and optimization driven technologies. We suggest how it could be linked to other sub-models allowing for detailed agent-based simulation of water management behaviours. An early formulation is applied as an example to the Thames water resource system in the UK. The model uses centralised optimisation to calculate allocations but allows for rule-based operations as well in an effort to represent observed behaviours and rules with fidelity. The model is linked through import/export commands to a generic network model platform named Hydra. Benefits and limitations of the approach are discussed and planned work and potential use cases are outlined.

A Smart Load Interface and Voltage Regulator for Electrostatic Vibration Energy Harvester

NASA Astrophysics Data System (ADS)

Bedier, Mohammed; Basset, Philippe; Galayko, Dimitri

2016-11-01

This paper presents a new implementation in ams 0.35μm HV technology of a complete energy management system for an electrostatic vibrational energy harvester (e-VEH). It is based on the Bennet's doubler architecture and includes a load voltage regulator (LVR) and a smart Load Interface (LI) that are self-controlled with internal voltages for maximum power point tracking (MMPT). The CMOS implementation makes use of an energy harvester that is capable of producing up to 1.8μW at harmonic excitation, given its internal voltage is kept within its optimum. An intermediate LI stage and its controller makes use of a high side switch with zero static power level shifter, and a low power hysteresis comparator. A full circuit level simulation with a VHDL-AMS model of the e-VEH presented was successfully achieved, indicating that the proposed load interface controller consumes less than 100nW average power. Moreover, a LVR regulates the buffer and discharge the harvested energy into a generic resistive load maintaining the voltage within a nominal value of 2 Volts.

76 FR 36139 - Agency Information Collection Activities: Submission for OMB Review; Comment Request; Generic...

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Virtual milk for modelling and simulation of dairy processes.

PubMed

Munir, M T; Zhang, Y; Yu, W; Wilson, D I; Young, B R

2016-05-01

The modeling of dairy processing using a generic process simulator suffers from shortcomings, given that many simulators do not contain milk components in their component libraries. Recently, pseudo-milk components for a commercial process simulator were proposed for simulation and the current work extends this pseudo-milk concept by studying the effect of both total milk solids and temperature on key physical properties such as thermal conductivity, density, viscosity, and heat capacity. This paper also uses expanded fluid and power law models to predict milk viscosity over the temperature range from 4 to 75°C and develops a succinct regressed model for heat capacity as a function of temperature and fat composition. The pseudo-milk was validated by comparing the simulated and actual values of the physical properties of milk. The milk thermal conductivity, density, viscosity, and heat capacity showed differences of less than 2, 4, 3, and 1.5%, respectively, between the simulated results and actual values. This work extends the capabilities of the previously proposed pseudo-milk and of a process simulator to model dairy processes, processing different types of milk (e.g., whole milk, skim milk, and concentrated milk) with different intrinsic compositions, and to predict correct material and energy balances for dairy processes. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

The Portuguese generic medicines market: a policy analysis

PubMed Central

Simoens, Steven

2008-01-01

Objectives: This study aims to conduct a descriptive analysis of the policy environment surrounding the generic medicines retail market in Portugal. The policy analysis focuses on supply-side measures (i.e. market access, pricing, reference-pricing and reimbursement of generic medicines) and demand-side measures (i.e. incentives for physicians to prescribe, for pharmacists to dispense and for patients to use generic medicines). Methods: The policy analysis was based on an international literature review. Also, a simulation exercise was carried out to compute potential savings from substituting generic for originator medicines in Portugal using IMS Health data. Results: Portugal has developed a successful generic medicines market by increasing reimbursement of generic medicines (until October 2005), by introducing a reference-pricing system, by encouraging physicians to prescribe by international non-proprietary name (INN), and by allowing generic substitution by pharmacists. However, the development of the generic medicines market has been hindered by the existence of copies, pricing regulation, certain features of the reference-pricing system, weak incentives for physicians to prescribe generic medicines and a financial disincentive for pharmacists to dispense generic medicines. Increased generic substitution would be expected to reduce public expenditure on originator medicines by 45%. Conclusions: The development of the Portuguese generic medicines market has mainly been fuelled by supply-side measures. To support the further expansion of the market, policy makers need to strengthen demand-side measures inciting physicians to prescribe, pharmacists to dispense and patients to use generic medicines. PMID:25152781

Design of trials for interrupting the transmission of endemic pathogens.

PubMed

Silkey, Mariabeth; Homan, Tobias; Maire, Nicolas; Hiscox, Alexandra; Mukabana, Richard; Takken, Willem; Smith, Thomas A

2016-06-06

Many interventions against infectious diseases have geographically diffuse effects. This leads to contamination between arms in cluster-randomized trials (CRTs). Pathogen elimination is the goal of many intervention programs against infectious agents, but contamination means that standard CRT designs and analyses do not provide inferences about the potential of interventions to interrupt pathogen transmission at maximum scale-up. A generic model of disease transmission was used to simulate infections in stepped wedge cluster-randomized trials (SWCRTs) of a transmission-reducing intervention, where the intervention has spatially diffuse effects. Simulations of such trials were then used to examine the potential of such designs for providing generalizable causal inferences about the impact of such interventions, including measurements of the contamination effects. The simulations were applied to the geography of Rusinga Island, Lake Victoria, Kenya, the site of the SolarMal trial on the use of odor-baited mosquito traps to eliminate Plasmodium falciparum malaria. These were used to compare variants in the proposed SWCRT designs for the SolarMal trial. Measures of contamination effects were found that could be assessed in the simulated trials. Inspired by analyses of trials of insecticide-treated nets against malaria when applied to the geography of the SolarMal trial, these measures were found to be robust to different variants of SWCRT design. Analyses of the likely extent of contamination effects supported the choice of cluster size for the trial. The SWCRT is an appropriate design for trials that assess the feasibility of local elimination of a pathogen. The effects of incomplete coverage can be estimated by analyzing the extent of contamination between arms in such trials, and the estimates also support inferences about causality. The SolarMal example illustrates how generic transmission models incorporating spatial smoothing can be used to simulate such trials for a power calculation and optimization of cluster size and randomization strategies. The approach is applicable to a range of infectious diseases transmitted via environmental reservoirs or via arthropod vectors.

IntellWheels: modular development platform for intelligent wheelchairs.

PubMed

Braga, Rodrigo Antonio Marques; Petry, Marcelo; Reis, Luis Paulo; Moreira, António Paulo

2011-01-01

Intelligent wheelchairs (IWs) can become an important solution to the challenge of assisting individuals who have disabilities and are thus unable to perform their daily activities using classic powered wheelchairs. This article describes the concept and design of IntellWheels, a modular platform to facilitate the development of IWs through a multiagent system paradigm. In fact, modularity is achieved not only in the software perspective, but also through a generic hardware framework that was designed to fit, in a straightforward manner, almost any commercial powered wheelchair. Experimental results demonstrate the successful integration of all modules in the platform, providing safe motion to the IW. Furthermore, the results achieved with a prototype running in autonomous mode in simulated and mixed-reality environments also demonstrate the potential of our approach. Although some future research is still necessary to fully accomplish our objectives, preliminary tests have shown that IntellWheels will effectively reduce users' limitations, offering them a much more independent life.

Aerodynamics of powered missile separation from F/A-18 aircraft

NASA Technical Reports Server (NTRS)

Ahmad, J. U.; Shanks, S. P.; Buning, P. G.

1993-01-01

A 3D dynamic 'chimera' algorithm that solves the thin-layer Navier-Stokes equations over multiple moving bodies was modified to numerically simulate the aerodynamics, missile dynamics, and missile plume interactions of a missile separating from a generic wing and from an F/A-18 aircraft in transonic flow. The missile is mounted below the wing for missile separation from the wing and on the F/A-18 fuselage at the engine inlet side for missile separation from aircraft. Static and powered missile separation cases are considered to examine the influence of the missile and plume on the wing and F/A-18 fuselage and engine inlet. The aircraft and missile are at two degrees angle of attack, Reynolds number of 10 million, freestream Mach number of 1.05 and plume Mach number of 3.0. The computational results show the details of the flow field.

Satellite interference analysis and simulation using personal computers

NASA Astrophysics Data System (ADS)

Kantak, Anil

1988-03-01

This report presents the complete analysis and formulas necessary to quantify the interference experienced by a generic satellite communications receiving station due to an interfering satellite. Both satellites, the desired as well as the interfering satellite, are considered to be in elliptical orbits. Formulas are developed for the satellite look angles and the satellite transmit angles generally related to the land mask of the receiving station site for both satellites. Formulas for considering Doppler effect due to the satellite motion as well as the Earth's rotation are developed. The effect of the interfering-satellite signal modulation and the Doppler effect on the power received are considered. The statistical formulation of the interference effect is presented in the form of a histogram of the interference to the desired signal power ratio. Finally, a computer program suitable for microcomputers such as IBM AT is provided with the flowchart, a sample run, results of the run, and the program code.

Satellite Interference Analysis and Simulation Using Personal Computers

NASA Technical Reports Server (NTRS)

Kantak, Anil

1988-01-01

This report presents the complete analysis and formulas necessary to quantify the interference experienced by a generic satellite communications receiving station due to an interfering satellite. Both satellites, the desired as well as the interfering satellite, are considered to be in elliptical orbits. Formulas are developed for the satellite look angles and the satellite transmit angles generally related to the land mask of the receiving station site for both satellites. Formulas for considering Doppler effect due to the satellite motion as well as the Earth's rotation are developed. The effect of the interfering-satellite signal modulation and the Doppler effect on the power received are considered. The statistical formulation of the interference effect is presented in the form of a histogram of the interference to the desired signal power ratio. Finally, a computer program suitable for microcomputers such as IBM AT is provided with the flowchart, a sample run, results of the run, and the program code.

Short-duration virtual reality simulation training positively impacts performance during laparoscopic colectomy in animal model: results of a single-blinded randomized trial : VR warm-up for laparoscopic colectomy.

PubMed

Araujo, Sergio E A; Delaney, Conor P; Seid, Victor E; Imperiale, Antonio R; Bertoncini, Alexandre B; Nahas, Sergio C; Cecconello, Ivan

2014-09-01

Several studies have demonstrated skills transfer after virtual reality (VR) simulation training in laparoscopic surgery. However, the impact of VR simulation training on transfer of skills related to laparoscopic colectomy remains not investigated. The present study aimed at determining the impact of VR simulation warm-up on performance during laparoscopic colectomy in the porcine model. Fourteen residents naive to laparoscopic colectomy as surgeons were randomly assigned in block to two groups. Seven trainees completed a 2-h VR simulator training in the laparoscopic sigmoid colectomy module (study group). The remaining seven surgeons (control group) underwent no intervention. On the same day, all participants performed a sigmoid colectomy with anastomosis on a pig. All operations were video recorded. Two board-certified expert colorectal surgeons independently assessed performance during the colectomy on the swine. Examiners were blinded to group assignment. The two examiners used a previously validated clinical instrument specific to laparoscopic colectomy. The primary outcome was the generic and specific skills score values. Surgeons undergoing short-duration training on the VR simulator performed significantly better during laparoscopic colectomy on the pig regarding general and specific technical skills evaluation. The average score of generic skills was 17.2 (16.5-18) for the control group and 20.1 (16.5-22) for the study group (p = 0.002). The specific skills average score for the control group was 20.2 (19-21.5) and 24.2 (21-27.5) for the study group (p = 0.001). There was acceptable concordance (Kendall's W) regarding the video assessment of generic (W = 0.78) and specific skills (W = 0.84) between the two examiners. A single short-duration VR simulator practice positively impacted surgeons' generic and specific skills performance required to accomplish laparoscopic colectomy in the swine model.

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Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-23

..., Revision 2; ``Generic Aging Lessons Learned (GALL) Report'' AGENCY: Nuclear Regulatory Commission (NRC... Nuclear Power Plants'' and NUREG-1801, Revision 2; ``Generic Aging Lessons Learned (GALL) Report... Lessons Learned (GALL) Report.'' These revised documents describe methods acceptable to the NRC staff for...

An Integrated Approach to Conversion, Verification, Validation and Integrity of AFRL Generic Engine Model and Simulation (Postprint)

DTIC Science & Technology

2007-02-01

and Astronautics 11 PS3C W3 P3 T3 FAR3 Ps3 W41 P41 T41 FAR41 Ps41 W4 P4 T4 FAR4 Ps4 7 NozFlow 6 Flow45 5 Flow44 4 Flow41 3 Flow4 2 Flow3 1 N2Bal... Motivation for Modeling and Simulation Work The Augmented Generic Engine Model (AGEM) Model Verification and Validation (V&V) Assessment of AGEM V&V

Integrated-Circuit Controller For Brushless dc Motor

NASA Technical Reports Server (NTRS)

Le, Dong Tuan

1994-01-01

Generic circuit performs commutation-logic and power-switching functions for control of brushless dc motor. Controller includes commutation-logic and associated control circuitry, power supply, and inverters containing power transistors. Major advantages of controller are size, weight, and power consumption can be made less than other brushless-dc-motor controllers.

Spacecraft Electrical Power System (EPS) generic analysis tools and techniques

NASA Technical Reports Server (NTRS)

Morris, Gladys M.; Sheppard, Mark A.

1992-01-01

An overview is provided of the analysis tools and techiques used in modeling the Space Station Freedom electrical power system, as well as future space vehicle power systems. The analysis capabilities of the Electrical Power System (EPS) are described and the EPS analysis tools are surveyed.

Using peer-assisted learning and role-playing to teach generic skills to dental students: the health care simulation model.

PubMed

El Tantawi, Maha M A; Abdelaziz, Hytham; AbdelRaheem, Amira S; Mahrous, Ahmed A

2014-01-01

Increasing importance is attached to teaching generic skills to undergraduate students in various disciplines. This article describes an extracurricular, student-led activity for teaching generic skills using the Model United Nations over three months. The activity used the Health Care Simulation Model (HCSM) with peer learning and role-playing to accomplish its objectives. An interview was used to select from undergraduate and postgraduate dental students at Alexandria University, Alexandria, Egypt, to develop a group of staff to act as peer teachers after receiving training (n=77). These peer teachers provided training for 123 undergraduate dental students to serve as delegates who acted as trainees or peer learners. At the end of the training sessions, a conference was held in which the students played the roles of delegates representing officials responsible for health care systems in ten countries. The students reported improvement in generic skills, enjoyed several aspects of the experience, and disliked other aspects of the model to a lesser extent. In multivariate analysis, perceived usefulness of the HCSM was significantly greater for staff than delegates and increased as self-reported improvement in knowledge of health care systems increased. This study suggests that innovative, student-centered educational methods can be effective for teaching generic skills and factual information.

Optimization design and laser damage threshold analysis of pulse compression multilayer dielectric gratings

NASA Astrophysics Data System (ADS)

Fan, Shuwei; Bai, Liang; Chen, Nana

2016-08-01

As one of the key elements of high-power laser systems, the pulse compression multilayer dielectric grating is required for broader band, higher diffraction efficiency and higher damage threshold. In this paper, the multilayer dielectric film and the multilayer dielectric gratings(MDG) were designed by eigen matrix and optimized with the help of generic algorithm and rigorous coupled wave method. The reflectivity was close to 100% and the bandwith were over 250nm, twice compared to the unoptimized film structure. The simulation software of standing wave field distribution within MDG was developed and the electric field of the MDG was calculated. And the key parameters which affected the electric field distribution were also studied.

A generic multibody simulation

NASA Technical Reports Server (NTRS)

Hopping, K. A.; Kohn, W.

1986-01-01

Described is a dynamic simulation package which can be configured for orbital test scenarios involving multiple bodies. The rotational and translational state integration methods are selectable for each individual body and may be changed during a run if necessary. Characteristics of the bodies are determined by assigning components consisting of mass properties, forces, and moments, which are the outputs of user-defined environmental models. Generic model implementation is facilitated by a transformation processor which performs coordinate frame inversions. Transformations are defined in the initialization file as part of the simulation configuration. The simulation package includes an initialization processor, which consists of a command line preprocessor, a general purpose grammar, and a syntax scanner. These permit specifications of the bodies, their interrelationships, and their initial states in a format that is not dependent on a particular test scenario.

The Modular Aero-Propulsion System Simulation (MAPSS) Users' Guide

NASA Technical Reports Server (NTRS)

Parker, Khary I.; Melcher, Kevin J.

2004-01-01

The Modular Aero-Propulsion System Simulation is a flexible turbofan engine simulation environment that provides the user a platform to develop advanced control algorithms. It is capable of testing the performance of control designs on a validated and verified generic engine model. In addition, it is able to generate state-space linear models of the engine model to aid in controller design. The engine model used in MAPSS is a generic high-pressure ratio, dual-spool, lowbypass, military-type, variable cycle turbofan engine with a digital controller. MAPSS is controlled by a graphical user interface (GUI) and this guide explains how to use it to take advantage of the capabilities of MAPSS.

Comparison of Standard Wind Turbine Models with Vendor Models for Power System Stability Analysis: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Honrubia-Escribano, A.; Gomez Lazaro, E.; Jimenez-Buendia, F.

The International Electrotechnical Commission Standard 61400-27-1 was published in February 2015. This standard deals with the development of generic terms and parameters to specify the electrical characteristics of wind turbines. Generic models of very complex technological systems, such as wind turbines, are thus defined based on the four common configurations available in the market. Due to its recent publication, the comparison of the response of generic models with specific vendor models plays a key role in ensuring the widespread use of this standard. This paper compares the response of a specific Gamesa dynamic wind turbine model to the corresponding genericmore » IEC Type III wind turbine model response when the wind turbine is subjected to a three-phase voltage dip. This Type III model represents the doubly-fed induction generator wind turbine, which is not only one of the most commonly sold and installed technologies in the current market but also a complex variable-speed operation implementation. In fact, active and reactive power transients are observed due to the voltage reduction. Special attention is given to the reactive power injection provided by the wind turbine models because it is a requirement of current grid codes. Further, the boundaries of the generic models associated with transient events that cannot be represented exactly are included in the paper.« less

Thermal Modeling and Analysis of a Cryogenic Tank Design Exposed to Extreme Heating Profiles

NASA Technical Reports Server (NTRS)

Stephens, Craig A.; Hanna, Gregory J.

1991-01-01

A cryogenic test article, the Generic Research Cryogenic Tank, was designed to qualitatively simulate the thermal response of transatmospheric vehicle fuel tanks exposed to the environment of hypersonic flight. One-dimensional and two-dimensional finite-difference thermal models were developed to simulate the thermal response and assist in the design of the Generic Research Cryogenic Tank. The one-dimensional thermal analysis determined the required insulation thickness to meet the thermal design criteria and located the purge jacket to eliminate the liquefaction of air. The two-dimensional thermal analysis predicted the temperature gradients developed within the pressure-vessel wall, estimated the cryogen boiloff, and showed the effects the ullage condition has on pressure-vessel temperatures. The degree of ullage mixing, location of the applied high-temperature profile, and the purge gas influence on insulation thermal conductivity had significant effects on the thermal behavior of the Generic Research Cryogenic Tank. In addition to analysis results, a description of the Generic Research Cryogenic Tank and the role it will play in future thermal structures and transatmospheric vehicle research at the NASA Dryden Flight Research Facility is presented.

Shared Memory Parallelism for 3D Cartesian Discrete Ordinates Solver

NASA Astrophysics Data System (ADS)

Moustafa, Salli; Dutka-Malen, Ivan; Plagne, Laurent; Ponçot, Angélique; Ramet, Pierre

2014-06-01

This paper describes the design and the performance of DOMINO, a 3D Cartesian SN solver that implements two nested levels of parallelism (multicore+SIMD) on shared memory computation nodes. DOMINO is written in C++, a multi-paradigm programming language that enables the use of powerful and generic parallel programming tools such as Intel TBB and Eigen. These two libraries allow us to combine multi-thread parallelism with vector operations in an efficient and yet portable way. As a result, DOMINO can exploit the full power of modern multi-core processors and is able to tackle very large simulations, that usually require large HPC clusters, using a single computing node. For example, DOMINO solves a 3D full core PWR eigenvalue problem involving 26 energy groups, 288 angular directions (S16), 46 × 106 spatial cells and 1 × 1012 DoFs within 11 hours on a single 32-core SMP node. This represents a sustained performance of 235 GFlops and 40:74% of the SMP node peak performance for the DOMINO sweep implementation. The very high Flops/Watt ratio of DOMINO makes it a very interesting building block for a future many-nodes nuclear simulation tool.

Practical and Creative Simulations for Training Personnel in Deafblindness.

ERIC Educational Resources Information Center

Olson, Joyce; Grondin, Jennifer

This monograph describes how to conduct simulations that allow individuals to experience what it is like to have deafblindness. It begins by discussing the philosophy and benefits of simulations and explains the two different types of simulations. The first type of simulation gives a generic overview of the impact of deafblindness on learning and…

Proceedings of the 1987 conference on tools for the simulation profession

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hawkins, R.; Klukis, K.

1987-01-01

This book covers the proceedings of the 1987 conference on tools for the simulation profession. Some of the topics are: SIMULACT: a generic tool for simulating distributed systems; ESL language simulation of spacecraft batteries; and Trends in global cadmium levels from increased use of fossil fuels.

"I'm No Lady Astronaut": Nonsexist Language for Tomorrow.

ERIC Educational Resources Information Center

Vardell, Sylvia M.

As a powerful tool for education, language informs, influences, discloses, and communicates. Research on the use of language has found that it also discriminates. Among the different manifestations of sexism in language are (1) the use of "he" as a generic pronoun; (2) the "generic" use of "man" as an exclusively male referent; (3) the use of "you…

Blockage effects on the hydrodynamic performance of a marine cross-flow turbine.

PubMed

Consul, Claudio A; Willden, Richard H J; McIntosh, Simon C

2013-02-28

This paper explores the influence of blockage and free-surface deformation on the hydrodynamic performance of a generic marine cross-flow turbine. Flows through a three-bladed turbine with solidity 0.125 are simulated at field-test blade Reynolds numbers, O(10(5)-10(6)), for three different cross-stream blockages: 12.5, 25 and 50 per cent. Two representations of the free-surface boundary are considered: rigid lid and deformable free surface. Increasing the blockage is observed to lead to substantial increases in the power coefficient; the highest power coefficient computed is 1.23. Only small differences are observed between the two free-surface representations, with the deforming free-surface turbine out-performing the rigid lid turbine by 6.7 per cent in power at the highest blockage considered. This difference is attributed to the increase in effective blockage owing to the deformation of the free surface. Hydrodynamic efficiency, the ratio of useful power generated to overall power removed from the flow, is found to increase with blockage, which is consistent with the presence of a higher flow velocity through the core of the turbine at higher blockage ratios. Froude number is found to have little effect on thrust and power coefficients, but significant influence on surface elevation drop across the turbine.

An implementation of a reference symbol approach to generic modulation in fading channels

NASA Technical Reports Server (NTRS)

Young, R. J.; Lodge, J. H.; Pacola, L. C.

1990-01-01

As mobile satellite communications systems evolve over the next decade, they will have to adapt to a changing tradeoff between bandwidth and power. This paper presents a flexible approach to digital modulation and coding that will accommodate both wideband and narrowband schemes. This architecture could be the basis for a family of modems, each satisfying a specific power and bandwidth constraint, yet all having a large number of common signal processing blocks. The implementation of this generic approach, with general purpose digital processors for transmission of 4.8 kilobits per sec. digitally encoded speech, is described.

Investigation of Bose Condensation in Ideal Bose Gas Trapped under Generic Power Law Potential in d Dimension

NASA Astrophysics Data System (ADS)

Mehedi Faruk, Mir; Sazzad Hossain, Md.; Muktadir Rahman, Md.

2016-02-01

The changes in characteristics of Bose condensation of ideal Bose gas due to an external generic power law potential U=\\sumi=1dci\\vert xi/ai\\vertni are studied carefully. Detailed calculation of Kim et al. (J. Phys. Condens. Matter 11 (1999) 10269) yielded the hierarchy of condensation transitions with changing fractional dimensionality. In this manuscript, some theorems regarding specific heat at constant volume CV are presented. Careful examination of these theorems reveal the existence of hidden hierarchy of the condensation transition in trapped systems as well.

Effects of flow-path variations on internal reversing flow in a tailpipe offtake configuration for ASTOVL aircraft

NASA Technical Reports Server (NTRS)

Mcardle, Jack G.; Esker, Barbara S.

1993-01-01

A one-third-scale model of a generic tailpipe offtake system for an advanced short takeoff, vertical landing (ASTOVL) aircraft was tested at the NASA Lewis Research Center Powered Lift Facility. The basic model consisted of a tailpipe with a center body to form an annulus simulating turbine outflow with no swirl; twin offtake ducts with elbows at the ends to turn the flow to a downward direction; flow control nozzles at the ends of the elbows; and a blind flange at the end of the tailpipe to simulate a closed cruise nozzle. The offtake duct-to-tailpipe diameter ratio was 0.74. Modifications of a generic nature were then made to this basic configuration to measure the effects of flow-path changes on the flow and pressure-loss characteristics. The modifications included adding rounded entrances at the forward edges of the offtake openings, blocking the tailpipe just aft the openings instead of at the cruise nozzle, changing the location of the openings along the tailpipe, removing the center body, and varying the Mach number (flow rate) over a wide range in the tailpipe ahead of the openings by changing the size of the flow control nozzles. The tests were made with unheated air at tailpipe-to-ambient pressure ratios from 1.4 to 5. Results are presented and compared with performance graphs, total-pressure contour plots, paint streak flow visualization photographs, and a flow-angle probe traverse at the offtake entrance.

A Nonlinear Dynamic Inversion Predictor-Based Model Reference Adaptive Controller for a Generic Transport Model

NASA Technical Reports Server (NTRS)

Campbell, Stefan F.; Kaneshige, John T.

2010-01-01

Presented here is a Predictor-Based Model Reference Adaptive Control (PMRAC) architecture for a generic transport aircraft. At its core, this architecture features a three-axis, non-linear, dynamic-inversion controller. Command inputs for this baseline controller are provided by pilot roll-rate, pitch-rate, and sideslip commands. This paper will first thoroughly present the baseline controller followed by a description of the PMRAC adaptive augmentation to this control system. Results are presented via a full-scale, nonlinear simulation of NASA s Generic Transport Model (GTM).

Development of a generic GMCC simulator.

DOT National Transportation Integrated Search

2001-11-01

This document describes the development and current status of a high fidelity, human-in-the-loop simulator for Airway Facilities : Maintenance Control Centers and Operations Control Centers. Applications include Event Manager, Maintenance Automation ...

Hand-assisted laparoscopic sigmoid colectomy skills acquisition: augmented reality simulator versus human cadaver training models.

PubMed

Leblanc, Fabien; Senagore, Anthony J; Ellis, Clyde N; Champagne, Bradley J; Augestad, Knut M; Neary, Paul C; Delaney, Conor P

2010-01-01

The aim of this study was to compare a simulator with the human cadaver model for hand-assisted laparoscopic colorectal skills acquisition training. An observational prospective comparative study was conducted to compare the laparoscopic surgery training models. The study took place during the laparoscopic colectomy training course performed at the annual scientific meeting of the American Society of Colon and Rectal Surgeons. Thirty four practicing surgeons performed hand-assisted laparoscopic sigmoid colectomy on human cadavers (n = 7) and on an augmented reality simulator (n = 27). Prior laparoscopic colorectal experience was assessed. Trainers and trainees completed independently objective structured assessment forms. Training models were compared by trainees' technical skills scores, events scores, and satisfaction. Prior laparoscopic experience was similar in both surgeon groups. Generic and specific skills scores were similar on both training models. Generic events scores were significantly better on the cadaver model. The 2 most frequent generic events occurring on the simulator were poor hand-eye coordination and inefficient use of retraction. Specific events were scored better on the simulator and reached the significance limit (p = 0.051) for trainers. The specific events occurring on the cadaver were intestinal perforation and left ureter identification difficulties. Overall satisfaction was better for the cadaver than for the simulator model (p = 0.009). With regard to skills scores, the augmented reality simulator had adequate qualities for the hand-assisted laparoscopic colectomy training. Nevertheless, events scores highlighted weaknesses of the anatomical replication on the simulator. Although improvements likely will be required to incorporate the simulator more routinely into the colorectal training, it may be useful in its current form for more junior trainees or those early on their learning curve. Copyright 2010 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Investigation of an alternative generic model for predicting pharmacokinetic changes during physiological stress.

PubMed

Peng, Henry T; Edginton, Andrea N; Cheung, Bob

2013-10-01

Physiologically based pharmacokinetic models were developed using MATLAB Simulink® and PK-Sim®. We compared the capability and usefulness of these two models by simulating pharmacokinetic changes of midazolam under exercise and heat stress to verify the usefulness of MATLAB Simulink® as a generic PBPK modeling software. Although both models show good agreement with experimental data obtained under resting condition, their predictions of pharmacokinetics changes are less accurate in the stressful conditions. However, MATLAB Simulink® may be more flexible to include physiologically based processes such as oral absorption and simulate various stress parameters such as stress intensity, duration and timing of drug administration to improve model performance. Further work will be conducted to modify algorithms in our generic model developed using MATLAB Simulink® and to investigate pharmacokinetics under other physiological stress such as trauma. © The Author(s) 2013.

NASA Workshop on Computational Structural Mechanics 1987, part 2

NASA Technical Reports Server (NTRS)

Sykes, Nancy P. (Editor)

1989-01-01

Advanced methods and testbed/simulator development topics are discussed. Computational Structural Mechanics (CSM) testbed architecture, engine structures simulation, applications to laminate structures, and a generic element processor are among the topics covered.

Composite Load Spectra for Select Space Propulsion Structural Components

NASA Technical Reports Server (NTRS)

Ho, Hing W.; Newell, James F.

1994-01-01

Generic load models are described with multiple levels of progressive sophistication to simulate the composite (combined) load spectra (CLS) that are induced in space propulsion system components, representative of Space Shuttle Main Engines (SSME), such as transfer ducts, turbine blades and liquid oxygen (LOX) posts. These generic (coupled) models combine the deterministic models for composite load dynamic, acoustic, high-pressure and high rotational speed, etc., load simulation using statistically varying coefficients. These coefficients are then determined using advanced probabilistic simulation methods with and without strategically selected experimental data. The entire simulation process is included in a CLS computer code. Applications of the computer code to various components in conjunction with the PSAM (Probabilistic Structural Analysis Method) to perform probabilistic load evaluation and life prediction evaluations are also described to illustrate the effectiveness of the coupled model approach.

Research on Formation of Microsatellite Communication with Genetic Algorithm

PubMed Central

Wu, Guoqiang; Bai, Yuguang; Sun, Zhaowei

2013-01-01

For the formation of three microsatellites which fly in the same orbit and perform three-dimensional solid mapping for terra, this paper proposes an optimizing design method of space circular formation order based on improved generic algorithm and provides an intersatellite direct spread spectrum communication system. The calculating equation of LEO formation flying satellite intersatellite links is guided by the special requirements of formation-flying microsatellite intersatellite links, and the transmitter power is also confirmed throughout the simulation. The method of space circular formation order optimizing design based on improved generic algorithm is given, and it can keep formation order steady for a long time under various absorb impetus. The intersatellite direct spread spectrum communication system is also provided. It can be found that, when the distance is 1 km and the data rate is 1 Mbps, the input wave matches preferably with the output wave. And LDPC code can improve the communication performance. The correct capability of (512, 256) LDPC code is better than (2, 1, 7) convolution code, distinctively. The design system can satisfy the communication requirements of microsatellites. So, the presented method provides a significant theory foundation for formation-flying and intersatellite communication. PMID:24078796

Research on formation of microsatellite communication with genetic algorithm.

PubMed

Wu, Guoqiang; Bai, Yuguang; Sun, Zhaowei

2013-01-01

For the formation of three microsatellites which fly in the same orbit and perform three-dimensional solid mapping for terra, this paper proposes an optimizing design method of space circular formation order based on improved generic algorithm and provides an intersatellite direct spread spectrum communication system. The calculating equation of LEO formation flying satellite intersatellite links is guided by the special requirements of formation-flying microsatellite intersatellite links, and the transmitter power is also confirmed throughout the simulation. The method of space circular formation order optimizing design based on improved generic algorithm is given, and it can keep formation order steady for a long time under various absorb impetus. The intersatellite direct spread spectrum communication system is also provided. It can be found that, when the distance is 1 km and the data rate is 1 Mbps, the input wave matches preferably with the output wave. And LDPC code can improve the communication performance. The correct capability of (512, 256) LDPC code is better than (2, 1, 7) convolution code, distinctively. The design system can satisfy the communication requirements of microsatellites. So, the presented method provides a significant theory foundation for formation-flying and intersatellite communication.

Practical Methods for the Analysis of Voltage Collapse in Electric Power Systems: a Stationary Bifurcations Viewpoint.

NASA Astrophysics Data System (ADS)

Jean-Jumeau, Rene

1993-03-01

Voltage collapse (VC) is generally caused by either of two types of system disturbances: load variations and contingencies. In this thesis, we study VC resulting from load variations. This is termed static voltage collapse. This thesis deals with this type of voltage collapse in electrical power systems by using a stationary bifurcations viewpoint by associating it with the occurrence of saddle node bifurcations (SNB) in the system. Approximate models are generically used in most VC analyses. We consider the validity of these models for the study of SNB and, thus, of voltage collapse. We justify the use of saddle node bifurcation as a model for VC in power systems. In particular, we prove that this leads to definition of a model and--since load demand is used as a parameter for that model--of a mode of parameterization of that model in order to represent actual power demand variations within the power system network. Ill-conditioning of the set of nonlinear equations defining a dynamical system is a generic occurence near the SNB point. We suggest a reparameterization of the set of nonlinear equations which allows to avoid this problem. A new indicator for the proximity of voltage collapse, the voltage collapse index (VCI), is developed. A new (n + 1)-dimensional set of characteristic equations for the computation of the exact SNB point, replacing the standard (2n + 1)-dimensional one is presented for general parameter -dependent nonlinear dynamical systems. These results are then applied to electric power systems for the analysis and prediction of voltage collapse. The new methods offer the potential of faster computation and greater flexibility. For reasons of theoretical development and clarity, the preceding methodologies are developed under the assumption of the absence of constraints on the system parameters and states, and the full differentiability of the functions defining the power system model. In the latter part of this thesis, we relax these assumptions in order to develop a framework and new formulation for application of the tools previously developed for the analysis and prediction of voltage collapse in practical power system models which include numerous constraints and discontinuities. Illustrations and numerical simulations throughout the thesis support our results.

Systematic simulations of modified gravity: chameleon models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brax, Philippe; Davis, Anne-Christine; Li, Baojiu

2013-04-01

In this work we systematically study the linear and nonlinear structure formation in chameleon theories of modified gravity, using a generic parameterisation which describes a large class of models using only 4 parameters. For this we have modified the N-body simulation code ecosmog to perform a total of 65 simulations for different models and parameter values, including the default ΛCDM. These simulations enable us to explore a significant portion of the parameter space. We have studied the effects of modified gravity on the matter power spectrum and mass function, and found a rich and interesting phenomenology where the difference withmore » the ΛCDM paradigm cannot be reproduced by a linear analysis even on scales as large as k ∼ 0.05 hMpc{sup −1}, since the latter incorrectly assumes that the modification of gravity depends only on the background matter density. Our results show that the chameleon screening mechanism is significantly more efficient than other mechanisms such as the dilaton and symmetron, especially in high-density regions and at early times, and can serve as a guidance to determine the parts of the chameleon parameter space which are cosmologically interesting and thus merit further studies in the future.« less

78 FR 70588 - STP Nuclear Operating Company; South Texas Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-26

... efficiency; (8) wind power; (9) solar power; (10) hydroelectric power; (11) ocean wave and current energy... generic environmental impact statement for license renewal of nuclear plants; issuance. SUMMARY: Notice is hereby given that the U.S. Nuclear Regulatory Commission (NRC) has published the final, plant-specific...

21 CFR 886.1350 - Keratoscope.

Code of Federal Regulations, 2013 CFR

2013-04-01

...-powered or battery-powered device intended to measure and evaluate the corneal curvature of the eye. Lines and circles within the keratoscope are used to observe the corneal reflex. This generic type of device... subject to § 886.9. The battery-powered device is exempt from the current good manufacturing practice...

21 CFR 886.1350 - Keratoscope.

Code of Federal Regulations, 2012 CFR

2012-04-01

...-powered or battery-powered device intended to measure and evaluate the corneal curvature of the eye. Lines and circles within the keratoscope are used to observe the corneal reflex. This generic type of device... subject to § 886.9. The battery-powered device is exempt from the current good manufacturing practice...

21 CFR 886.1350 - Keratoscope.

Code of Federal Regulations, 2014 CFR

2014-04-01

...-powered or battery-powered device intended to measure and evaluate the corneal curvature of the eye. Lines and circles within the keratoscope are used to observe the corneal reflex. This generic type of device... subject to § 886.9. The battery-powered device is exempt from the current good manufacturing practice...

21 CFR 886.1350 - Keratoscope.

Code of Federal Regulations, 2011 CFR

2011-04-01

...-powered or battery-powered device intended to measure and evaluate the corneal curvature of the eye. Lines and circles within the keratoscope are used to observe the corneal reflex. This generic type of device... subject to § 886.9. The battery-powered device is exempt from the current good manufacturing practice...

21 CFR 886.1350 - Keratoscope.

Code of Federal Regulations, 2010 CFR

2010-04-01

...-powered or battery-powered device intended to measure and evaluate the corneal curvature of the eye. Lines and circles within the keratoscope are used to observe the corneal reflex. This generic type of device... subject to § 886.9. The battery-powered device is exempt from the current good manufacturing practice...

Developing competitive and sustainable Polish generic medicines market.

PubMed

Simoens, Steven

2009-10-01

To descriptively analyze the policy environment surrounding the Polish generic medicines retail market. The policy analysis was based on an international literature review. Also, a simulation exercise was carried out to compute potential savings from substituting generic for originator medicines in Poland using IMS Health pharmaceutical intelligence data. Poland has a mature, high-volume, low-value generic medicines market, primarily driven by the establishment of the reference price at the price of the cheapest medicine in combination with pricing regulation and the low level of medicine prices. The practice of discounting in the distribution chain implies that the National Health Fund and patients do not capture the potential savings from a generic medicines market where companies compete on price. This high-volume market has benefited in the past from the limited availability of originator medicines and a short data exclusivity period, even though there are no incentives for physicians to prescribe generic medicines and a financial disincentive for pharmacists to dispense generic medicines. Increased generic substitution would be expected to reduce public expenditure on originator medicines by 21%. To develop a competitive and sustainable market, Poland needs to consider moving away from competition by discount to competition by price. This could be achieved by replacing maximum distribution margins by fixed margins. Also, Poland may wish to raise reference prices as a temporary measure to boost market entry for medicine classes with few generic medicines.

Basic Operational Robotics Instructional System

NASA Technical Reports Server (NTRS)

Todd, Brian Keith; Fischer, James; Falgout, Jane; Schweers, John

2013-01-01

The Basic Operational Robotics Instructional System (BORIS) is a six-degree-of-freedom rotational robotic manipulator system simulation used for training of fundamental robotics concepts, with in-line shoulder, offset elbow, and offset wrist. BORIS is used to provide generic robotics training to aerospace professionals including flight crews, flight controllers, and robotics instructors. It uses forward kinematic and inverse kinematic algorithms to simulate joint and end-effector motion, combined with a multibody dynamics model, moving-object contact model, and X-Windows based graphical user interfaces, coordinated in the Trick Simulation modeling environment. The motivation for development of BORIS was the need for a generic system for basic robotics training. Before BORIS, introductory robotics training was done with either the SRMS (Shuttle Remote Manipulator System) or SSRMS (Space Station Remote Manipulator System) simulations. The unique construction of each of these systems required some specialized training that distracted students from the ideas and goals of the basic robotics instruction.

Price regulation and generic competition in the pharmaceutical market.

PubMed

Dalen, Dag Morten; Strøm, Steinar; Haabeth, Tonje

2006-09-01

In March 2003 the Norwegian government implemented yardstick-based price regulation schemes on a selection of drugs subjected to generic competition. The retail price cap, termed the "index price," on a drug (chemical substance) was set equal to the average of the three lowest producer prices on that drug, plus a fixed wholesale and retail margin. This is supposed to lower barriers of entry for generic drugs and to trigger price competition. Using monthly data over the period 1998-2004 for the six drugs (chemical entities) included in the index price system, we estimate a structural model enabling us to examine the impact of the reform on both demand and market power. Our results suggest that the index price helped to increase the market shares of generic drugs and succeeded in triggering price competition.

Economic savings versus health losses: The cost-effectiveness of generic antiretroviral therapy in the United States

PubMed Central

Walensky, Rochelle P.; Sax, Paul E.; Nakamura, Yoriko M.; Weinstein, Milton C.; Pei, Pamela P.; Freedberg, Kenneth A.; Paltiel, A. David; Schackman, Bruce R.

2013-01-01

Background US HIV treatment guidelines recommend branded once-daily, one-pill efavirenz/emtricitabine/tenofovir as preferred first-line antiretroviral treatment (ART). With the anticipated approval of generic efavirenz in 2012 in the US, the cost of a once-daily, three-pill alternative (generic efavirenz, generic lamivudine, tenofovir) will decrease, but adherence and virologic suppression may be reduced. Objectives To assess the clinical impact, costs, and cost-effectiveness of the generic-based three-pill regimen compared to the branded, co-formulated regimen. To project the potential national savings in the first year of a switch to generic-based ART. Design Mathematical simulation of HIV disease. Data Sources Published data from US clinical trials and observational cohorts. Target Population HIV-infected patients eligible to start on or switch to an efavirenz-based generic ART regimen. Time Horizon Lifetime, One-year Perspective US health system Interventions No ART (for comparison), Three-pill Generic ART, and Branded ART Outcome Measures Quality-adjusted life expectancy, costs, and incremental cost-effectiveness ratios (ICER, $/quality-adjusted life expectancy [QALY]). Results of Base-Case Analysis Compared to No ART, Generic ART has an ICER of $21,100/QALY. Compared to Generic ART, Branded ART increases lifetime costs by $42,500, and per-person survival gains by 0.37 QALYs, for an ICER of $114,800/QALY. Estimated first-year savings, if all eligible US patients start on or switch to Generic ART, are $920 million. Results of Sensitivity Analysis Most plausible assumptions about Generic ART efficacy and costs lead to Branded ART ICERs >$100,000/QALY. Limitations The efficacy and price reduction associated with generics are unknown; estimates are intended to be conservative. Conclusions Compared to a slightly less effective generic-based regimen, the cost-effectiveness of first-line Branded ART exceeds $100,000/QALY. Generic-based ART in the US could yield substantial budgetary savings to HIV programs. PMID:23318310

Responses in large-scale structure

NASA Astrophysics Data System (ADS)

Barreira, Alexandre; Schmidt, Fabian

2017-06-01

We introduce a rigorous definition of general power-spectrum responses as resummed vertices with two hard and n soft momenta in cosmological perturbation theory. These responses measure the impact of long-wavelength perturbations on the local small-scale power spectrum. The kinematic structure of the responses (i.e., their angular dependence) can be decomposed unambiguously through a ``bias'' expansion of the local power spectrum, with a fixed number of physical response coefficients, which are only a function of the hard wavenumber k. Further, the responses up to n-th order completely describe the (n+2)-point function in the squeezed limit, i.e. with two hard and n soft modes, which one can use to derive the response coefficients. This generalizes previous results, which relate the angle-averaged squeezed limit to isotropic response coefficients. We derive the complete expression of first- and second-order responses at leading order in perturbation theory, and present extrapolations to nonlinear scales based on simulation measurements of the isotropic response coefficients. As an application, we use these results to predict the non-Gaussian part of the angle-averaged matter power spectrum covariance CovNGl=0(k1,k2), in the limit where one of the modes, say k2, is much smaller than the other. Without any free parameters, our model results are in very good agreement with simulations for k2 lesssim 0.06 h Mpc-1, and for any k1 gtrsim 2k2. The well-defined kinematic structure of the power spectrum response also permits a quick evaluation of the angular dependence of the covariance matrix. While we focus on the matter density field, the formalism presented here can be generalized to generic tracers such as galaxies.

A Simulation and Modeling Framework for Space Situational Awareness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Olivier, S S

This paper describes the development and initial demonstration of a new, integrated modeling and simulation framework, encompassing the space situational awareness enterprise, for quantitatively assessing the benefit of specific sensor systems, technologies and data analysis techniques. The framework is based on a flexible, scalable architecture to enable efficient, physics-based simulation of the current SSA enterprise, and to accommodate future advancements in SSA systems. In particular, the code is designed to take advantage of massively parallel computer systems available, for example, at Lawrence Livermore National Laboratory. The details of the modeling and simulation framework are described, including hydrodynamic models of satellitemore » intercept and debris generation, orbital propagation algorithms, radar cross section calculations, optical brightness calculations, generic radar system models, generic optical system models, specific Space Surveillance Network models, object detection algorithms, orbit determination algorithms, and visualization tools. The use of this integrated simulation and modeling framework on a specific scenario involving space debris is demonstrated.« less

Parameter estimation method that directly compares gravitational wave observations to numerical relativity

NASA Astrophysics Data System (ADS)

Lange, J.; O'Shaughnessy, R.; Boyle, M.; Calderón Bustillo, J.; Campanelli, M.; Chu, T.; Clark, J. A.; Demos, N.; Fong, H.; Healy, J.; Hemberger, D. A.; Hinder, I.; Jani, K.; Khamesra, B.; Kidder, L. E.; Kumar, P.; Laguna, P.; Lousto, C. O.; Lovelace, G.; Ossokine, S.; Pfeiffer, H.; Scheel, M. A.; Shoemaker, D. M.; Szilagyi, B.; Teukolsky, S.; Zlochower, Y.

2017-11-01

We present and assess a Bayesian method to interpret gravitational wave signals from binary black holes. Our method directly compares gravitational wave data to numerical relativity (NR) simulations. In this study, we present a detailed investigation of the systematic and statistical parameter estimation errors of this method. This procedure bypasses approximations used in semianalytical models for compact binary coalescence. In this work, we use the full posterior parameter distribution for only generic nonprecessing binaries, drawing inferences away from the set of NR simulations used, via interpolation of a single scalar quantity (the marginalized log likelihood, ln L ) evaluated by comparing data to nonprecessing binary black hole simulations. We also compare the data to generic simulations, and discuss the effectiveness of this procedure for generic sources. We specifically assess the impact of higher order modes, repeating our interpretation with both l ≤2 as well as l ≤3 harmonic modes. Using the l ≤3 higher modes, we gain more information from the signal and can better constrain the parameters of the gravitational wave signal. We assess and quantify several sources of systematic error that our procedure could introduce, including simulation resolution and duration; most are negligible. We show through examples that our method can recover the parameters for equal mass, zero spin, GW150914-like, and unequal mass, precessing spin sources. Our study of this new parameter estimation method demonstrates that we can quantify and understand the systematic and statistical error. This method allows us to use higher order modes from numerical relativity simulations to better constrain the black hole binary parameters.

Incorporating a Generic Model of Subcutaneous Insulin Absorption into the AIDA v4 Diabetes Simulator: 1. A Prospective Collaborative Development Plan

PubMed Central

Lehmann, Eldon D.; Tarín, Cristina; Bondia, Jorge; Teufel, Edgar; Deutsch, Tibor

2007-01-01

Introduction AIDA v4 is an interactive educational diabetes simulator that has been made available, for over a decade, without charge via the Internet. The software is currently freely accessible at http://www.2aida.org. This report sets out a collaborative development plan to enhance the program with a new model of subcutaneous insulin absorption, which permits the simulation of rapidly acting and very long-acting insulin analogues, as well as insulin injection doses larger than 40 units. Methods A novel, generic, physiological subcutaneous insulin absorption model is overviewed and a methodology is proposed by which this can be substituted in place of the previously adopted insulin absorption model utilized within AIDA v4.3a. Apart from this substitution it is proposed to retain the existing model of the glucoregulatory system currently used in AIDA v4.3a. Results Initial simulation results based on bench testing of this approach using MATLAB are presented for the exogenous insulin flow profile (Iex) following subcutaneous injections of a rapidly acting insulin analogue, a short-acting (regular) insulin preparation, intermediate-acting insulins (both Semilente and neutral protamine Hagedorn types), and a very long-acting insulin analogue. Discussion It is proposed to implement this collaborative development plan—first by bench testing the approach in MATLAB and then by integrating the generic subcutaneous insulin absorption Iex model into the AIDA simulator in Pascal. The aim is to provide enhanced functionality and educational simulations of regimens utilizing novel insulin analogues, as well as injections larger than 40 units of insulin. PMID:19885100

10 CFR 51.95 - Postconstruction environmental impact statements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... determined by the Commission, a supplement on the operation of a nuclear power plant will not include a... the storage of spent fuel for the nuclear power plant within the scope of the generic determination in... the renewal of an operating license or combined license for a nuclear power plant under parts 52 or 54...

A generic multi-flex-body dynamics, controls simulation tool for space station

NASA Technical Reports Server (NTRS)

London, Ken W.; Lee, John F.; Singh, Ramen P.; Schubele, Buddy

1991-01-01

An order (n) multiflex body Space Station simulation tool is introduced. The flex multibody modeling is generic enough to model all phases of Space Station from build up through to Assembly Complete configuration and beyond. Multibody subsystems such as the Mobile Servicing System (MSS) undergoing a prescribed translation and rotation are also allowed. The software includes aerodynamic, gravity gradient, and magnetic field models. User defined controllers can be discrete or continuous. Extensive preprocessing of 'body by body' NASTRAN flex data is built in. A significant aspect, too, is the integrated controls design capability which includes model reduction and analytic linearization.

Development of an Integrated Nonlinear Aeroservoelastic Flight Dynamic Model of the NASA Generic Transport Model

NASA Technical Reports Server (NTRS)

Nguyen, Nhan; Ting, Eric

2018-01-01

This paper describes a recent development of an integrated fully coupled aeroservoelastic flight dynamic model of the NASA Generic Transport Model (GTM). The integrated model couples nonlinear flight dynamics to a nonlinear aeroelastic model of the GTM. The nonlinearity includes the coupling of the rigid-body aircraft states in the partial derivatives of the aeroelastic angle of attack. Aeroservoelastic modeling of the control surfaces which are modeled by the Variable Camber Continuous Trailing Edge Flap is also conducted. The R.T. Jones' method is implemented to approximate unsteady aerodynamics. Simulations of the GTM are conducted with simulated continuous and discrete gust loads..

An optimal generic model for multi-parameters and big data optimizing: a laboratory experimental study

NASA Astrophysics Data System (ADS)

Utama, D. N.; Ani, N.; Iqbal, M. M.

2018-03-01

Optimization is a process for finding parameter (parameters) that is (are) able to deliver an optimal value for an objective function. Seeking an optimal generic model for optimizing is a computer science study that has been being practically conducted by numerous researchers. Generic model is a model that can be technically operated to solve any varieties of optimization problem. By using an object-oriented method, the generic model for optimizing was constructed. Moreover, two types of optimization method, simulated-annealing and hill-climbing, were functioned in constructing the model and compared to find the most optimal one then. The result said that both methods gave the same result for a value of objective function and the hill-climbing based model consumed the shortest running time.

Predictive aging results for cable materials in nuclear power plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gillen, K.T.; Clough, R.L.

1990-11-01

In this report, we provide a detailed discussion of methodology of predicting cable degradation versus dose rate, temperature, and exposure time and its application to data obtained on a number of additional nuclear power plant cable insulation (a hypalon, a silicon rubber and two ethylenetetrafluoroethylenes) and jacket (a hypalon) materials. We then show that the predicted, low-dose-rate results for our materials are in excellent agreement with long-term (7 to 9 years), low dose-rate results recently obtained for the same material types actually aged under nuclear power plant conditions. Based on a combination of the modelling and long-term results, we findmore » indications of reasonably similar degradation responses among several different commercial formulations for each of the following generic'' materials: hypalon, ethylenetetrafluoroethylene, silicone rubber and PVC. If such generic'' behavior can be further substantiated through modelling and long-term results on additional formulations, predictions of cable life for other commercial materials of the same generic types would be greatly facilitated. Finally, to aid utilities in their cable life extension decisions, we utilize our modelling results to generate lifetime prediction curves for the materials modelled to data. These curves plot expected material lifetime versus dose rate and temperature down to the levels of interest to nuclear power plant aging. 18 refs., 30 figs., 3 tabs.« less

Directional control-response compatibility relationships assessed by physical simulation of an underground bolting machine.

PubMed

Steiner, Lisa; Burgess-Limerick, Robin; Porter, William

2014-03-01

The authors examine the pattern of direction errors made during the manipulation of a physical simulation of an underground coal mine bolting machine to assess the directional control-response compatibility relationships associated with the device and to compare these results to data obtained from a virtual simulation of a generic device. Directional errors during the manual control of underground coal roof bolting equipment are associated with serious injuries. Directional control-response relationships have previously been examined using a virtual simulation of a generic device; however, the applicability of these results to a specific physical device may be questioned. Forty-eight participants randomly assigned to different directional control-response relationships manipulated horizontal or vertical control levers to move a simulated bolter arm in three directions (elevation, slew, and sump) as well as to cause a light to become illuminated and raise or lower a stabilizing jack. Directional errors were recorded during the completion of 240 trials by each participant Directional error rates are increased when the control and response are in opposite directions or if the direction of the control and response are perpendicular.The pattern of direction error rates was consistent with experiments obtained from a generic device in a virtual environment. Error rates are increased by incompatible directional control-response relationships. Ensuring that the design of equipment controls maintains compatible directional control-response relationships has potential to reduce the errors made in high-risk situations, such as underground coal mining.

Integrated Targeting and Guidance for Powered Planetary Descent

NASA Astrophysics Data System (ADS)

Azimov, Dilmurat M.; Bishop, Robert H.

2018-02-01

This paper presents an on-board guidance and targeting design that enables explicit state and thrust vector control and on-board targeting for planetary descent and landing. These capabilities are developed utilizing a new closed-form solution for the constant thrust arc of the braking phase of the powered descent trajectory. The key elements of proven targeting and guidance architectures, including braking and approach phase quartics, are employed. It is demonstrated that implementation of the proposed solution avoids numerical simulation iterations, thereby facilitating on-board execution of targeting procedures during the descent. It is shown that the shape of the braking phase constant thrust arc is highly dependent on initial mass and propulsion system parameters. The analytic solution process is explicit in terms of targeting and guidance parameters, while remaining generic with respect to planetary body and descent trajectory design. These features increase the feasibility of extending the proposed integrated targeting and guidance design to future cargo and robotic landing missions.

Integrated Targeting and Guidance for Powered Planetary Descent

NASA Astrophysics Data System (ADS)

Azimov, Dilmurat M.; Bishop, Robert H.

2018-06-01

This paper presents an on-board guidance and targeting design that enables explicit state and thrust vector control and on-board targeting for planetary descent and landing. These capabilities are developed utilizing a new closed-form solution for the constant thrust arc of the braking phase of the powered descent trajectory. The key elements of proven targeting and guidance architectures, including braking and approach phase quartics, are employed. It is demonstrated that implementation of the proposed solution avoids numerical simulation iterations, thereby facilitating on-board execution of targeting procedures during the descent. It is shown that the shape of the braking phase constant thrust arc is highly dependent on initial mass and propulsion system parameters. The analytic solution process is explicit in terms of targeting and guidance parameters, while remaining generic with respect to planetary body and descent trajectory design. These features increase the feasibility of extending the proposed integrated targeting and guidance design to future cargo and robotic landing missions.

Composite load spectra for select space propulsion structural components

NASA Technical Reports Server (NTRS)

Newell, J. F.; Ho, H. W.; Kurth, R. E.

1991-01-01

The work performed to develop composite load spectra (CLS) for the Space Shuttle Main Engine (SSME) using probabilistic methods. The three methods were implemented to be the engine system influence model. RASCAL was chosen to be the principal method as most component load models were implemented with the method. Validation of RASCAL was performed. High accuracy comparable to the Monte Carlo method can be obtained if a large enough bin size is used. Generic probabilistic models were developed and implemented for load calculations using the probabilistic methods discussed above. Each engine mission, either a real fighter or a test, has three mission phases: the engine start transient phase, the steady state phase, and the engine cut off transient phase. Power level and engine operating inlet conditions change during a mission. The load calculation module provides the steady-state and quasi-steady state calculation procedures with duty-cycle-data option. The quasi-steady state procedure is for engine transient phase calculations. In addition, a few generic probabilistic load models were also developed for specific conditions. These include the fixed transient spike model, the poison arrival transient spike model, and the rare event model. These generic probabilistic load models provide sufficient latitude for simulating loads with specific conditions. For SSME components, turbine blades, transfer ducts, LOX post, and the high pressure oxidizer turbopump (HPOTP) discharge duct were selected for application of the CLS program. They include static pressure loads and dynamic pressure loads for all four components, centrifugal force for the turbine blade, temperatures of thermal loads for all four components, and structural vibration loads for the ducts and LOX posts.

Aerodynamics Model for a Generic ASTOVL Lift-Fan Aircraft

DOT National Transportation Integrated Search

1995-04-01

This report describes the aerodynamics model used in a simulation model of : an advanced short takeoff and vertical landing lift-far fighter aircraft. The : simulation model was developed for use in piloted evaluations of transition and : hover fligh...

Generic Software for Emulating Multiprocessor Architectures.

DTIC Science & Technology

1985-05-01

RD-A157 662 GENERIC SOFTWARE FOR EMULATING MULTIPROCESSOR 1/2 AlRCHITECTURES(J) MASSACHUSETTS INST OF TECH CAMBRIDGE U LRS LAB FOR COMPUTER SCIENCE R...AREA & WORK UNIT NUMBERS MIT Laboratory for Computer Science 545 Technology Square Cambridge, MA 02139 ____________ I I. CONTROLLING OFFICE NAME AND...aide If neceeasy end Identify by block number) Computer architecture, emulation, simulation, dataf low 20. ABSTRACT (Continue an reverse slde It

Fault Diagnosis in HVAC Chillers

NASA Technical Reports Server (NTRS)

Choi, Kihoon; Namuru, Setu M.; Azam, Mohammad S.; Luo, Jianhui; Pattipati, Krishna R.; Patterson-Hine, Ann

2005-01-01

Modern buildings are being equipped with increasingly sophisticated power and control systems with substantial capabilities for monitoring and controlling the amenities. Operational problems associated with heating, ventilation, and air-conditioning (HVAC) systems plague many commercial buildings, often the result of degraded equipment, failed sensors, improper installation, poor maintenance, and improperly implemented controls. Most existing HVAC fault-diagnostic schemes are based on analytical models and knowledge bases. These schemes are adequate for generic systems. However, real-world systems significantly differ from the generic ones and necessitate modifications of the models and/or customization of the standard knowledge bases, which can be labor intensive. Data-driven techniques for fault detection and isolation (FDI) have a close relationship with pattern recognition, wherein one seeks to categorize the input-output data into normal or faulty classes. Owing to the simplicity and adaptability, customization of a data-driven FDI approach does not require in-depth knowledge of the HVAC system. It enables the building system operators to improve energy efficiency and maintain the desired comfort level at a reduced cost. In this article, we consider a data-driven approach for FDI of chillers in HVAC systems. To diagnose the faults of interest in the chiller, we employ multiway dynamic principal component analysis (MPCA), multiway partial least squares (MPLS), and support vector machines (SVMs). The simulation of a chiller under various fault conditions is conducted using a standard chiller simulator from the American Society of Heating, Refrigerating, and Air-conditioning Engineers (ASHRAE). We validated our FDI scheme using experimental data obtained from different types of chiller faults.

The generic danger and the idiosyncratic support

NASA Astrophysics Data System (ADS)

Temme, Arnaud; Nijp, Jelmer; van der Meij, Marijn; Samia, Jalal; Masselink, Rens

2016-04-01

This contribution argues two main points. First, that generic landscapes used in some modelling studies sometimes have properties or cause simulation results that are unrealistic. Such initially flat or straight-sloped landscapes, sometimes with minor random perturbations, e.g. form the backdrop for ecological simulations of vegetation growth and competition that predict catastrophic shifts. Exploratory results for semi-arid systems suggest that the results based on these generic landscapes are end-members from a distribution of results, rather than an unbiased, typical outcome. Apparently, the desire to avoid idiosyncrasy has unintended consequences. Second, we argue and illustrate that in fact new insights often come from close inspection of idiosyncratic case studies. Our examples from landslide systems, connectivity and soil formation show how a central role for the case study - either in empirical work or to provide model targets - has advanced our understanding. Both points contribute to the conclusion that it is dangerous to forget about annoying, small-scale, idiosyncratic and, indeed, perhaps bad-ass case studies in Earth Sciences.

Economic impact of generic substitution of lamotrigine: projected costs in the US using findings in a Canadian setting.

PubMed

LeLorier, Jacques; Duh, Mei Sheng; Paradis, Pierre Emmanuel; Latrémouille-Viau, Dominick; Lefebvre, Patrick; Manjunath, Ranjani; Sheehy, Odile

2008-04-01

Generic substitution may not always save health care costs for antiepileptic drugs (AED). (1) To examine the economic impacts of generic substitution of lamotrigine in Canada; and (2) to convert observed Canadian costs to a United States (US) setting. Health claims from Québec's health plan (RAMQ) between 08/2002 and 07/2006 were analyzed. Patients with > or = 1 epilepsy claim and treated with branded lamotrigine (Lamictal) before generic entry were selected. Health care costs ($/person-year) were compared during periods of branded and generic use of lamotrigine. Two cost-conversion methods were employed; one using purchasing power parities, US/Canada service use ratios, and exchange rate, and another employing Canadian health care utilization and US unit costs. 671 patients were observed during 1650.9 and 291.2 person-years of branded and generic use of lamotrigine, respectively. The generic-use period was associated with an increase in overall costs (2006 constant Canadian dollars) relative to brand use (C$7902 vs. C$6419/person-year; cost ratio (CR) = 1.22; p = 0.05), despite the lower cost of generic lamotrigine. Non-lamotrigine costs were 33% higher in the generic period (p = 0.013). Both conversion methods yielded increases in total projected health care costs excluding lamotrigine (2006 constant US dollars) during the generic period (Method 1: cost difference: US$1758/person-year, CR = 1.33, p = 0.01); Method 2: cost difference: US$2516, CR = 1.39, p = 0.004). Study limitations pertain to treatment differences, indicators used for conversion and possible claim inaccuracies. Use of generic lamotrigine in Canada was significantly associated with increased overall medical costs compared to brand use. Projected overall US health care costs would likely increase as well.

Molecular simulation workflows as parallel algorithms: the execution engine of Copernicus, a distributed high-performance computing platform.

PubMed

Pronk, Sander; Pouya, Iman; Lundborg, Magnus; Rotskoff, Grant; Wesén, Björn; Kasson, Peter M; Lindahl, Erik

2015-06-09

Computational chemistry and other simulation fields are critically dependent on computing resources, but few problems scale efficiently to the hundreds of thousands of processors available in current supercomputers-particularly for molecular dynamics. This has turned into a bottleneck as new hardware generations primarily provide more processing units rather than making individual units much faster, which simulation applications are addressing by increasingly focusing on sampling with algorithms such as free-energy perturbation, Markov state modeling, metadynamics, or milestoning. All these rely on combining results from multiple simulations into a single observation. They are potentially powerful approaches that aim to predict experimental observables directly, but this comes at the expense of added complexity in selecting sampling strategies and keeping track of dozens to thousands of simulations and their dependencies. Here, we describe how the distributed execution framework Copernicus allows the expression of such algorithms in generic workflows: dataflow programs. Because dataflow algorithms explicitly state dependencies of each constituent part, algorithms only need to be described on conceptual level, after which the execution is maximally parallel. The fully automated execution facilitates the optimization of these algorithms with adaptive sampling, where undersampled regions are automatically detected and targeted without user intervention. We show how several such algorithms can be formulated for computational chemistry problems, and how they are executed efficiently with many loosely coupled simulations using either distributed or parallel resources with Copernicus.

Developing Competitive and Sustainable Polish Generic Medicines Market

PubMed Central

Simoens, Steven

2009-01-01

Aim To descriptively analyze the policy environment surrounding the Polish generic medicines retail market. Method The policy analysis was based on an international literature review. Also, a simulation exercise was carried out to compute potential savings from substituting generic for originator medicines in Poland using IMS Health pharmaceutical intelligence data. Results Poland has a mature, high-volume, low-value generic medicines market, primarily driven by the establishment of the reference price at the price of the cheapest medicine in combination with pricing regulation and the low level of medicine prices. The practice of discounting in the distribution chain implies that the National Health Fund and patients do not capture the potential savings from a generic medicines market where companies compete on price. This high-volume market has benefited in the past from the limited availability of originator medicines and a short data exclusivity period, even though there are no incentives for physicians to prescribe generic medicines and a financial disincentive for pharmacists to dispense generic medicines. Increased generic substitution would be expected to reduce public expenditure on originator medicines by 21%. Conclusion To develop a competitive and sustainable market, Poland needs to consider moving away from competition by discount to competition by price. This could be achieved by replacing maximum distribution margins by fixed margins. Also, Poland may wish to raise reference prices as a temporary measure to boost market entry for medicine classes with few generic medicines. PMID:19839067

Review of PREPA Technical Requirements for Interconnecting Wind and Solar Generation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gevorgian, Vahan; Booth, Sarah

2013-11-01

The Puerto Rico Electric Power Authority developed the minimum technical requirements for interconnection of wind turbine generation and photovoltaic power plants. NREL has conducted a review of these requirements based on generic technical aspects and electrical characteristics of wind and photovoltaic power plants, and on existing requirements from other utilities (both U.S. and European).

75 FR 16521 - Virginia Electric and Power Company Surry Power Station, Unit Nos. 1 and 2; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... generic industry request to extend the rule's compliance date for all operating nuclear power plants, but... M.S. Fertel, Nuclear Energy Institute). The licensee's request for an exemption is therefore... granting of this exemption will not have a significant effect on the quality of the human environment (75...

Model helicopter performance degradation with simulated ice shapes

NASA Technical Reports Server (NTRS)

Tinetti, Ana F.; Korkan, Kenneth D.

1987-01-01

An experimental program using a commercially available model helicopter has been conducted in the Texas A&M University Subsonic Wind Tunnel to investigate main rotor performance degradation due to generic ice. The simulated ice, including both primary and secondary formations, was scaled by chord from previously documented artificial ice accretions. Base and iced performance data were gathered as functions of fuselage incidence, blade collective pitch, main rotor rotational velocity, and freestream velocity. It was observed that the presence of simulated ice tends to decrease the lift to equivalent drag ratio, as well as thrust coefficient for the range of velocity ratios tested. Also, increases in torque coefficient due to the generic ice formations were observed. Evaluation of the data has indicated that the addition of roughness due to secondary ice formations is crucial for proper evaluation of the degradation in main rotor performance.

Power supply expansion and the nuclear option in Poland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marnay, C.; Pickle, S.

Poland is in the process of liberalizing and modernizing its electric power system. Given its heavy reliance on coal and a consequent history of often severe environmental externalities associated with power production, the nature of capacity expansion in Poland has important environmental and social implications. To better understand capacity expansion in Poland, we constructed a data set of the Polish power sector for use with the Elfin capacity expansion planning model. Using Elfin, we derived four scenarios and several sensitivities for new generating capacity construction. These scenarios simulate choices among several generic generating technologies made to achieve the lowest overallmore » net present cost of operating the power system through 2015. We find that natural gas is a highly desirable fuel for future power generation in Poland, but primarily as a peaking resource. As the current system is inflexible and peaking capacity appears to be the most pressing need, this result is not surprising. However, when nuclear power is included as a generation option, natural gas is less desirable than the Polish Power Grid Company (PPGCo) has suggested, and, despite the PPGCo`s claims to the contrary, nuclear power cannot be ruled out in Poland on economic grounds alone. In the unconstrained Elfin scenarios, using PPGCo assumptions, nuclear power is attractive, especially after 2010. The attractiveness of nuclear generation proves sensitive to certain input variables, however, notably fixed operating and maintenance cost, and possible carbon taxes. Moreover, we find that the effectiveness of conservation efforts designed to reduce airborne emissions is limited under scenarios in which nuclear generation is adopted. 23 refs., 11 figs., 5 tabs.« less

Overview of free-piston Stirling technology at the NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Slaby, J. G.

1985-01-01

An overview of the National Aeronautics and Space Administration (NASA) Lewis Research Center (Lewis) free-piston Stirling engine activities is presented. These activities include: (1) a generic free-piston Stirling technology project being conducted to develop technologies synergistic to both space power and terrestrial heat pump applications in a cooperative, cost-shared effort with the Department of Energy (DOE/Oak Ridge National Laboratory (ONRL)), and (2) a free-piston Stirling space-power technology demonstration project as part of the SP-100 program being conducted in support of the Department of Defense (DOD), DOE, and NASA/Lewis. The generic technology effort includes extensive parametric testing of a 1 kw free-piston Stirling engine (RE-1000), development and validation of a free-piston Stirling performance computer code, and fabrication and initial testing of an hydraulic output modification for the RE-1000 engine. The space power technology effort, under SP-100, addresses the status of the 25 kWe Space Power Demonstrator Engine (SPDE) including early test results.

Assessment of Health-Related Quality of Life after TBI: Comparison of a Disease-Specific (QOLIBRI) with a Generic (SF-36) Instrument

PubMed Central

von Steinbuechel, Nicole; Covic, Amra; Polinder, Suzanne; Kohlmann, Thomas; Cepulyte, Ugne; Poinstingl, Herbert; Backhaus, Joy; Bakx, Wilbert; Bullinger, Monika; Christensen, Anne-Lise; Formisano, Rita; Gibbons, Henning; Höfer, Stefan; Koskinen, Sanna; Maas, Andrew; Neugebauer, Edmund; Powell, Jane; Sarajuuri, Jaana; Sasse, Nadine; Schmidt, Silke; Mühlan, Holger; von Wild, Klaus; Zitnay, George; Truelle, Jean-Luc

2016-01-01

Psychosocial, emotional, and physical problems can emerge after traumatic brain injury (TBI), potentially impacting health-related quality of life (HRQoL). Until now, however, neither the discriminatory power of disease-specific (QOLIBRI) and generic (SF-36) HRQoL nor their correlates have been compared in detail. These aspects as well as some psychometric item characteristics were studied in a sample of 795 TBI survivors. The Shannon H ' index absolute informativity, as an indicator of an instrument's power to differentiate between individuals within a specific group or health state, was investigated. Psychometric performance of the two instruments was predominantly good, generally higher, and more homogenous for the QOLIBRI than for the SF-36 subscales. Notably, the SF-36 “Role Physical,” “Role Emotional,” and “Social Functioning” subscales showed less satisfactory discriminatory power than all other dimensions or the sum scores of both instruments. The absolute informativity of disease-specific as well as generic HRQoL instruments concerning the different groups defined by different correlates differed significantly. When the focus is on how a certain subscale or sum score differentiates between individuals in one specific dimension/health state, the QOLIBRI can be recommended as the preferable instrument. PMID:27022207

Generic framework for mining cellular automata models on protein-folding simulations.

PubMed

Diaz, N; Tischer, I

2016-05-13

Cellular automata model identification is an important way of building simplified simulation models. In this study, we describe a generic architectural framework to ease the development process of new metaheuristic-based algorithms for cellular automata model identification in protein-folding trajectories. Our framework was developed by a methodology based on design patterns that allow an improved experience for new algorithms development. The usefulness of the proposed framework is demonstrated by the implementation of four algorithms, able to obtain extremely precise cellular automata models of the protein-folding process with a protein contact map representation. Dynamic rules obtained by the proposed approach are discussed, and future use for the new tool is outlined.

CMG-Augmented Control of a Hovering VTOL Platform

NASA Technical Reports Server (NTRS)

Lim, K. B.; Moerder, D. D.

2007-01-01

This paper describes how Control Moment Gyroscopes (CMGs) can be used for stability augmentation to a thrust vectoring system for a generic Vertical Take-Off and Landing platform. The response characteristics of the platform which uses only thrust vectoring and a second configuration which includes a single-gimbal CMG array are simulated and compared for hovering flight while subject to severe air turbulence. Simulation results demonstrate the effectiveness of a CMG array in its ability to significantly reduce the agility requirement on the thrust vectoring system. Albeit simplifying physical assumptions on a generic CMG configuration, the numerical results also suggest that reasonably sized CMGs will likely be sufficient for a small hovering vehicle.

Thermal and hydrodynamic studies for micro-channel cooling for large area silicon sensors in high energy physics experiments

NASA Astrophysics Data System (ADS)

Flaschel, Nils; Ariza, Dario; Díez, Sergio; Gerboles, Marta; Gregor, Ingrid-Maria; Jorda, Xavier; Mas, Roser; Quirion, David; Tackmann, Kerstin; Ullan, Miguel

2017-08-01

Micro-channel cooling initially aiming at small-sized high-power integrated circuits is being transferred to the field of high energy physics. Today's prospects of micro-fabricating silicon opens a door to a more direct cooling of detector modules. The challenge in high energy physics is to save material in the detector construction and to cool large areas. In this paper, we are investigating micro-channel cooling as a candidate for a future cooling system for silicon detectors in a generic research and development approach. The work presented in this paper includes the production and the hydrodynamic and thermal testing of a micro-channel equipped prototype optimized to achieve a homogeneous flow distribution. Furthermore, the device was simulated using finite element methods.

A comparison of human cadaver and augmented reality simulator models for straight laparoscopic colorectal skills acquisition training.

PubMed

LeBlanc, Fabien; Champagne, Bradley J; Augestad, Knut M; Neary, Paul C; Senagore, Anthony J; Ellis, Clyde N; Delaney, Conor P

2010-08-01

The aim of this study was to compare the human cadaver model with an augmented reality simulator for straight laparoscopic colorectal skills acquisition. Thirty-five sigmoid colectomies were performed on a cadaver (n = 7) or an augmented reality simulator (n = 28) during a laparoscopic training course. Prior laparoscopic colorectal experience was assessed. Objective structured technical skills assessment forms were completed by trainers and trainees independently. Groups were compared according to technical skills and events scores and satisfaction with training model. Prior laparoscopic experience was similar in both groups. For trainers and trainees, technical skills scores were considerably better on the simulator than on the cadaver. For trainers, generic events score was also considerably better on the simulator than on the cadaver. The main generic event occurring on both models was errors in the use of retraction. The main specific event occurring on both models was bowel perforation. Global satisfaction was better for the cadaver than for the simulator model (p < 0.001). The human cadaver model was more difficult but better appreciated than the simulator for laparoscopic sigmoid colectomy training. Simulator training followed by cadaver training can appropriately integrate simulators into the learning curve and maintain the benefits of both training methodologies. Published by Elsevier Inc.

Power-Laws and Scaling in Finance: Empirical Evidence and Simple Models

NASA Astrophysics Data System (ADS)

Bouchaud, Jean-Philippe

We discuss several models that may explain the origin of power-law distributions and power-law correlations in financial time series. From an empirical point of view, the exponents describing the tails of the price increments distribution and the decay of the volatility correlations are rather robust and suggest universality. However, many of the models that appear naturally (for example, to account for the distribution of wealth) contain some multiplicative noise, which generically leads to non universal exponents. Recent progress in the empirical study of the volatility suggests that the volatility results from some sort of multiplicative cascade. A convincing `microscopic' (i.e. trader based) model that explains this observation is however not yet available. We discuss a rather generic mechanism for long-ranged volatility correlations based on the idea that agents constantly switch between active and inactive strategies depending on their relative performance.

A feasibility study regarding the addition of a fifth control to a rotorcraft in-flight simulator

NASA Technical Reports Server (NTRS)

Turner, Simon; Andrisani, Dominick, II

1992-01-01

The addition of a large movable horizontal tail surface to the control system of a rotorcraft in-flight simulator being developed from a Sikorsky UH-60A Black Hawk Helicopter is evaluated. The capabilities of the control surface as a trim control and as an active control are explored. The helicopter dynamics are modeled using the Generic Helicopter simulation program developed by Sikorsky Aircraft. The effect of the horizontal tail on the helicopter trim envelope is examined by plotting trim maps of the aircraft attitude and controls as a function of the flight speed and horizontal tail incidence. The control power of the tail surface relative to that of the other controls is examined by comparing control derivatives extracted from the simulation program over the flight speed envelope. The horizontal tail's contribution as an active control is evaluated using an explicit model following control synthesis involving a linear model of the helicopter in steady, level flight at a flight speed of eighty knots. The horizontal tail is found to provide additional control flexibility in the longitudinal axis. As a trim control, it provides effective control of the trim pitch attitude at mid to high forward speeds. As an active control, the horizontal tail provides useful pitching moment generating capabilities at mid to high forward speeds.

In Vivo Radiofrequency Heating in Swine in a 3T (123.2 MHz) Birdcage Whole-Body Coil

PubMed Central

Shrivastava, Devashish; Utecht, Lynn; Tian, Jinfeng; Hughes, John; Vaughan, J. Thomas

2014-01-01

Purpose To study in vivo radiofrequency (RF) heating produced due to power deposition from a 3T (Larmour frequency = 123.2 MHz), birdcage, whole-body coil. Methods The RF heating was simulated in a digital swine by solving the mechanistic generic bioheat transfer model (GBHTM) and the conventional, empirical Pennes bioheat transfer equation for the following two cases: (1) when the porcine head was in the isocenter, and (2) when the porcine trunk was in the isocenter. The simulation results were validated by making direct fluoroptic temperature measurements in the skin, brain, simulated hot regions, and rectum of ten swine (Case 1, N= 5, mean animal weight = 84.03 ± 6.85 kg, Whole-body average SAR = 2.65 ± 0.22 W/kg; Case 2, N= 5, mean animal weight = 81.59 ± 6.23 kg, Whole-body average SAR = 2.77 ± 0.26 W/kg) during one hour of exposure to a turbo spin echo sequence. Results The GBHTM simulated the RF heating more accurately compared to the Pennes equation. In vivo temperatures exceeded safe temperature thresholds with allowable SAR exposures. Hot regions may be produced deep inside the body, away from the skin. Conclusion SAR exposures to produce safe temperature thresholds may need re-investigation. PMID:24259413

Intelligent Systems Approach for Automated Identification of Individual Control Behavior of a Human Operator

NASA Technical Reports Server (NTRS)

Zaychik, Kirill B.; Cardullo, Frank M.

2012-01-01

Results have been obtained using conventional techniques to model the generic human operator?s control behavior, however little research has been done to identify an individual based on control behavior. The hypothesis investigated is that different operators exhibit different control behavior when performing a given control task. Two enhancements to existing human operator models, which allow personalization of the modeled control behavior, are presented. One enhancement accounts for the testing control signals, which are introduced by an operator for more accurate control of the system and/or to adjust the control strategy. This uses the Artificial Neural Network which can be fine-tuned to model the testing control. Another enhancement takes the form of an equiripple filter which conditions the control system power spectrum. A novel automated parameter identification technique was developed to facilitate the identification process of the parameters of the selected models. This utilizes a Genetic Algorithm based optimization engine called the Bit-Climbing Algorithm. Enhancements were validated using experimental data obtained from three different sources: the Manual Control Laboratory software experiments, Unmanned Aerial Vehicle simulation, and NASA Langley Research Center Visual Motion Simulator studies. This manuscript also addresses applying human operator models to evaluate the effectiveness of motion feedback when simulating actual pilot control behavior in a flight simulator.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agarwal, Animesh, E-mail: animesh@zedat.fu-berlin.de; Delle Site, Luigi, E-mail: dellesite@fu-berlin.de

Quantum effects due to the spatial delocalization of light atoms are treated in molecular simulation via the path integral technique. Among several methods, Path Integral (PI) Molecular Dynamics (MD) is nowadays a powerful tool to investigate properties induced by spatial delocalization of atoms; however, computationally this technique is very demanding. The above mentioned limitation implies the restriction of PIMD applications to relatively small systems and short time scales. One of the possible solutions to overcome size and time limitation is to introduce PIMD algorithms into the Adaptive Resolution Simulation Scheme (AdResS). AdResS requires a relatively small region treated at pathmore » integral level and embeds it into a large molecular reservoir consisting of generic spherical coarse grained molecules. It was previously shown that the realization of the idea above, at a simple level, produced reasonable results for toy systems or simple/test systems like liquid parahydrogen. Encouraged by previous results, in this paper, we show the simulation of liquid water at room conditions where AdResS, in its latest and more accurate Grand-Canonical-like version (GC-AdResS), is merged with two of the most relevant PIMD techniques available in the literature. The comparison of our results with those reported in the literature and/or with those obtained from full PIMD simulations shows a highly satisfactory agreement.« less

Radio morphing - towards a full parametrisation of the radio signal from air showers

NASA Astrophysics Data System (ADS)

Zilles, A.; Charrier, D.; Kotera, K.; Le Coz, S.; Martineau-Huynh, O.; Medina, C.; Niess, V.; Tueros, M.; de Vries, K.

2017-12-01

Over the last decades, radio detection of air showers has been established as a detection technique for ultra-high-energy cosmic-rays impinging on the Earth's atmosphere with energies far beyond LHC energies. Today’s second-generation of digital radio-detection experiments, as e.g. AERA or LOFAR, are becoming competitive in comparison to already standard techniques e.g. fluorescence light detection. Thanks to a detailed understanding of the physics of the radio emission in extensive air showers, simulations of the radio signal are already successfully tested and applied in the reconstruction of cosmic rays. However the limits of the computational power resources are easily reached when it comes to computing electric fields at the numerous positions requested by large or dense antenna arrays. In the case of mountainous areas as e.g. for the GRAND array, where 3D shower simulations are necessary, the problem arises with even stronger acuity. Therefore we developed a full parametrisation of the emitted radio signal on the basis of generic shower simulations which will reduce the simulation time by orders of magnitudes. In this talk we will present this concept after a short introduction to the concept of the radio detection of air-shower induced by cosmic rays.

IMPACT: a generic tool for modelling and simulating public health policy.

PubMed

Ainsworth, J D; Carruthers, E; Couch, P; Green, N; O'Flaherty, M; Sperrin, M; Williams, R; Asghar, Z; Capewell, S; Buchan, I E

2011-01-01

Populations are under-served by local health policies and management of resources. This partly reflects a lack of realistically complex models to enable appraisal of a wide range of potential options. Rising computing power coupled with advances in machine learning and healthcare information now enables such models to be constructed and executed. However, such models are not generally accessible to public health practitioners who often lack the requisite technical knowledge or skills. To design and develop a system for creating, executing and analysing the results of simulated public health and healthcare policy interventions, in ways that are accessible and usable by modellers and policy-makers. The system requirements were captured and analysed in parallel with the statistical method development for the simulation engine. From the resulting software requirement specification the system architecture was designed, implemented and tested. A model for Coronary Heart Disease (CHD) was created and validated against empirical data. The system was successfully used to create and validate the CHD model. The initial validation results show concordance between the simulation results and the empirical data. We have demonstrated the ability to connect health policy-modellers and policy-makers in a unified system, thereby making population health models easier to share, maintain, reuse and deploy.

75 FR 54145 - Environmental Impacts Statements; Notice of Availability

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... to Construct a Concentrated Solar Thermal Power Plant Facility, Nye County, NV, Comment Period Ends..., GENERIC--License Renewal of Nuclear Plants for Kewaunee Power Station, Supplement 40 to NUREG-1437... EIS, NRC, GA, Vogtle Electric Generating Plant Units 3 and 4, Construction and Operation, Application...

10 CFR 51.95 - Postconstruction environmental impact statements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... the storage of spent fuel for the nuclear power plant within the scope of the generic determination in... a license to store spent fuel at a nuclear power reactor after expiration of the operating or... Section 51.95 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR...

10 CFR 51.95 - Postconstruction environmental impact statements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... the storage of spent fuel for the nuclear power plant within the scope of the generic determination in... a license to store spent fuel at a nuclear power reactor after expiration of the operating or... Section 51.95 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ENVIRONMENTAL PROTECTION REGULATIONS FOR...

NASA Tech Briefs, February 2006

NASA Technical Reports Server (NTRS)

2006-01-01

Topics discussed include: Nearly Direct Measurement of Relative Permittivity; DCS-Neural-Network Program for Aircraft Control and Testing; Dielectric Heaters for Testing Spacecraft Nuclear Reactors; Using Doppler Shifts of GPS Signals To Measure Angular Speed; Monitoring Temperatures of Tires Using Luminescent Materials; Highly Efficient Multilayer Thermoelectric Devices; Very High-Speed Digital Video Capability for In-Flight Use; MMIC DHBT Common-Base Amplifier for 172 GHz; Modular, Microprocessor-Controlled Flash Lighting System; Generic Environment for Simulating Launch Operations; Modular Aero-Propulsion System Simulation; X-Windows Socket Widget Class; Infrastructure for Rapid Development of Java GUI Programs; Processing Raman Spectra of High-Pressure Hydrogen Flames; X-Windows Information Sharing Protocol Widget Class; Simulating Humans as Integral Parts of Spacecraft Missions; Analyzing Power Supply and Demand on the ISS; Polyimides From a-BPDA and Aromatic Diamines; Making Plant-Support Structures From Waste Plant Fiber; Large Deployable Reflectarray Antenna; Periodically Discharging, Gas-Coalescing Filter; Ion Milling On Steps for Fabrication of Nanowires; Neuro-Prosthetic Implants With Adjustable Electrode Arrays; Microfluidic Devices for Studying Biomolecular Interactions; Studying Functions of All Yeast Genes Simultaneously; Polarization Phase-Compensating Coats for Metallic Mirrors; Tunable-Bandwidth Filter System; Methodology for Designing Fault-Protection Software; and Ground-Based Localization of Mars Rovers.

A comparative analysis of generics markets in five European countries.

PubMed

Garattini, L; Tediosi, F

2000-04-01

A generic medicine is a faithful copy of a mature drug--no longer under patent marketed with the chemical name of the active ingredient. This article analyses generics markets in five European countries: France, Germany Italy, The Netherlands and the U.K. The study investigate all the main issues--patent, approval to market, pricing and reimbursement, prescription and distribution--which affect the life cycle of a pharmaceutical product. The situation in the five countries varied widely. Because of European harmonization, patent legislation and approval procedures no longer affect much the development of generics. Only national legislation on patent protection approved before the EU directive came into force still plays a role. Approval differences seem to be due mainly to common practice, rather than to the regulations themselves. None of the countries have an efficient public information system on patent expiry. Generics have had more success in countries with more flexible pricing policies. Reimbursement has not yet been used widely to discriminate between generics and proprietary drugs. Financial incentives are based more on physicians' prescribing behaviour than on pharmacists. The freedom of pharmacy ownership and the consequent possibility of dispensing pharmaceuticals through different channels affects dramatically the structure of generics markets. A free market of wholesalers and retailers can enhance a comparative market, through horizontal and vertical integration all along the distribution chain. Such an environment has stimulate the success of unbranded generics by delegating strong purchasing power to distributors.

Estimating B1+ in the breast at 7 T using a generic template.

PubMed

van Rijssel, Michael J; Pluim, Josien P W; Luijten, Peter R; Gilhuijs, Kenneth G A; Raaijmakers, Alexander J E; Klomp, Dennis W J

2018-05-01

Dynamic contrast-enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B 1 + ) field inhomogeneities. B 1 + field information is required in order to correct these. The use of a generic, coil-specific B 1 + template is proposed and tested. Finite-difference time-domain simulations for B 1 + were performed for healthy female volunteers with a wide range of breast anatomies. A generic B 1 + template was constructed by averaging simulations based on four volunteers. Three-dimensional B 1 + maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B 1 + mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00-4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1-16%, with mean 11.7%. The agreement between the proposed template approach and a B 1 + mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B 1 + template. With local RF transmit coils, intersubject differences in B 1 + fields of the breast are comparable to the accuracy of B 1 + mapping methods, even at 7 T. Consequently, a single generic B 1 + template suits subjects over a wide range of breast anatomies, eliminating the need for a time-consuming B 1 + mapping protocol. © 2018 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

Estimating B 1 + in the breast at 7 T using a generic template

PubMed Central

Pluim, Josien P. W.; Luijten, Peter R.; Gilhuijs, Kenneth G. A.; Raaijmakers, Alexander J. E.; Klomp, Dennis W. J.

2018-01-01

Dynamic contrast‐enhanced MRI is the workhorse of breast MRI, where the diagnosis of lesions is largely based on the enhancement curve shape. However, this curve shape is biased by RF transmit (B 1 +) field inhomogeneities. B 1 + field information is required in order to correct these. The use of a generic, coil‐specific B 1 + template is proposed and tested. Finite‐difference time‐domain simulations for B 1 + were performed for healthy female volunteers with a wide range of breast anatomies. A generic B 1 + template was constructed by averaging simulations based on four volunteers. Three‐dimensional B 1 + maps were acquired in 15 other volunteers. Root mean square error (RMSE) metrics were calculated between individual simulations and the template, and between individual measurements and the template. The agreement between the proposed template approach and a B 1 + mapping method was compared against the agreement between acquisition and reacquisition using the same mapping protocol. RMSE values (% of nominal flip angle) comparing individual simulations with the template were in the range 2.00‐4.01%, with mean 2.68%. RMSE values comparing individual measurements with the template were in the range8.1‐16%, with mean 11.7%. The agreement between the proposed template approach and a B 1 + mapping method was only slightly worse than the agreement between two consecutive acquisitions using the same mapping protocol in one volunteer: the range of agreement increased from ±16% of the nominal angle for repeated measurement to ±22% for the B 1 + template. With local RF transmit coils, intersubject differences in B 1 + fields of the breast are comparable to the accuracy of B 1 + mapping methods, even at 7 T. Consequently, a single generic B 1 + template suits subjects over a wide range of breast anatomies, eliminating the need for a time‐consuming B 1 + mapping protocol. PMID:29570887

Recent advancements in medical simulation: patient-specific virtual reality simulation.

PubMed

Willaert, Willem I M; Aggarwal, Rajesh; Van Herzeele, Isabelle; Cheshire, Nicholas J; Vermassen, Frank E

2012-07-01

Patient-specific virtual reality simulation (PSVR) is a new technological advancement that allows practice of upcoming real operations and complements the established role of VR simulation as a generic training tool. This review describes current developments in PSVR and draws parallels with other high-stake industries, such as aviation, military, and sports. A review of the literature was performed using PubMed and Internet search engines to retrieve data relevant to PSVR in medicine. All reports pertaining to PSVR were included. Reports on simulators that did not incorporate a haptic interface device were excluded from the review. Fifteen reports described 12 simulators that enabled PSVR. Medical procedures in the field of laparoscopy, vascular surgery, orthopedics, neurosurgery, and plastic surgery were included. In all cases, source data was two-dimensional CT or MRI data. Face validity was most commonly reported. Only one (vascular) simulator had undergone face, content, and construct validity. Of the 12 simulators, 1 is commercialized and 11 are prototypes. Five simulators have been used in conjunction with real patient procedures. PSVR is a promising technological advance within medicine. The majority of simulators are still in the prototype phase. As further developments unfold, the validity of PSVR will have to be examined much like generic VR simulation for training purposes. Nonetheless, similar to the aviation, military, and sport industries, operative performance and patient safety may be enhanced by the application of this novel technology.

The Generic Resolution Advisor and Conflict Evaluator (GRACE) for Detect-And-Avoid (DAA) Systems

NASA Technical Reports Server (NTRS)

Abramson, Michael; Refai, Mohamad; Santiago, Confesor

2017-01-01

The paper describes the Generic Resolution Advisor and Conflict Evaluator (GRACE), a novel alerting and guidance algorithm that combines flexibility, robustness, and computational efficiency. GRACE is "generic" in that it makes no assumptions regarding temporal or spatial scales, aircraft performance, or its sensor and communication systems. Accordingly, GRACE is well suited to research applications where alerting and guidance is a central feature and requirements are fluid involving a wide range of aviation technologies. GRACE has been used at NASA in a number of real-time and fast-time experiments supporting evolving requirements of DAA research, including parametric studies, NAS-wide simulations, human-in-the-loop experiments, and live flight tests.

Mathematical Modeling Of Life-Support Systems

NASA Technical Reports Server (NTRS)

Seshan, Panchalam K.; Ganapathi, Balasubramanian; Jan, Darrell L.; Ferrall, Joseph F.; Rohatgi, Naresh K.

1994-01-01

Generic hierarchical model of life-support system developed to facilitate comparisons of options in design of system. Model represents combinations of interdependent subsystems supporting microbes, plants, fish, and land animals (including humans). Generic model enables rapid configuration of variety of specific life support component models for tradeoff studies culminating in single system design. Enables rapid evaluation of effects of substituting alternate technologies and even entire groups of technologies and subsystems. Used to synthesize and analyze life-support systems ranging from relatively simple, nonregenerative units like aquariums to complex closed-loop systems aboard submarines or spacecraft. Model, called Generic Modular Flow Schematic (GMFS), coded in such chemical-process-simulation languages as Aspen Plus and expressed as three-dimensional spreadsheet.

A generic simulation model to assess the performance of sterilization services in health establishments.

PubMed

Di Mascolo, Maria; Gouin, Alexia

2013-03-01

The work presented here is with a view to improving performance of sterilization services in hospitals. We carried out a survey in a large number of health establishments in the Rhône-Alpes region in France. Based on the results of this survey and a detailed study of a specific service, we have built a generic model. The generic nature of the model relies on a common structure with a high level of detail. This model can be used to improve the performance of a specific sterilization service and/or to dimension its resources. It can also serve for quantitative comparison of performance indicators of various sterilization services.

A generic approach for examining the effectiveness of traffic control devices in school zones.

PubMed

Zhao, Xiaohua; Li, Jiahui; Ding, Han; Zhang, Guohui; Rong, Jian

2015-09-01

The effectiveness and performance of traffic control devices in school zones have been impacted significantly by many factors, such as driver behavioral attributes, roadway geometric features, environmental characteristics, weather and visibility conditions, region-wide traffic regulations and policies, control modes, etc. When deploying traffic control devices in school zones, efforts are needed to clarify: (1) whether traffic control device installation is warranted; and (2) whether other device effectively complements this traffic control device and strengthens its effectiveness. In this study, a generic approach is developed to examine and evaluate the effectiveness of various traffic control devices deployed in school zones through driving simulator-based experiments. A Traffic Control Device Selection Model (TCDSM) is developed and two representative school zones are selected as the testbed in Beijing for driving simulation implementation to enhance its applicability. Statistical analyses are conducted to extract the knowledge from test data recorded by a driving simulator. Multiple measures of effectiveness (MOEs) are developed and adopted including average speed, relative speed difference, and standard deviation of acceleration for traffic control device performance quantification. The experimental tests and analysis results reveal that the appropriateness of the installation of certain traffic control devices can be statistically verified by TCDSM. The proposed approach provides a generic framework to assess traffic control device performance in school zones including experiment design, statistical formulation, data analysis, simulation model implementation, data interpretation, and recommendation development. Copyright © 2015 Elsevier Ltd. All rights reserved.

Faunus: An object oriented framework for molecular simulation

PubMed Central

Lund, Mikael; Trulsson, Martin; Persson, Björn

2008-01-01

Background We present a C++ class library for Monte Carlo simulation of molecular systems, including proteins in solution. The design is generic and highly modular, enabling multiple developers to easily implement additional features. The statistical mechanical methods are documented by extensive use of code comments that – subsequently – are collected to automatically build a web-based manual. Results We show how an object oriented design can be used to create an intuitively appealing coding framework for molecular simulation. This is exemplified in a minimalistic C++ program that can calculate protein protonation states. We further discuss performance issues related to high level coding abstraction. Conclusion C++ and the Standard Template Library (STL) provide a high-performance platform for generic molecular modeling. Automatic generation of code documentation from inline comments has proven particularly useful in that no separate manual needs to be maintained. PMID:18241331

Best Practices: Power Quality and Integrated Testing at JSC

NASA Technical Reports Server (NTRS)

Davis, Lydia

2018-01-01

This presentation discusses Best Practices for Power Quality and Integrated Testing at JSC in regards to electrical systems. These high-level charts include mostly generic information; however, a specific issue is discussed involving flight hardware that could have been discovered prior to flight with an integrated test.

Generic Software Architecture for Launchers

NASA Astrophysics Data System (ADS)

Carre, Emilien; Gast, Philippe; Hiron, Emmanuel; Leblanc, Alain; Lesens, David; Mescam, Emmanuelle; Moro, Pierre

2015-09-01

The definition and reuse of generic software architecture for launchers is not so usual for several reasons: the number of European launcher families is very small (Ariane 5 and Vega for these last decades); the real time constraints (reactivity and determinism needs) are very hard; low levels of versatility are required (implying often an ad hoc development of the launcher mission). In comparison, satellites are often built on a generic platform made up of reusable hardware building blocks (processors, star-trackers, gyroscopes, etc.) and reusable software building blocks (middleware, TM/TC, On Board Control Procedure, etc.). If some of these reasons are still valid (e.g. the limited number of development), the increase of the available CPU power makes today an approach based on a generic time triggered middleware (ensuring the full determinism of the system) and a centralised mission and vehicle management (offering more flexibility in the design and facilitating the long term maintenance) achievable. This paper presents an example of generic software architecture which could be envisaged for future launchers, based on the previously described principles and supported by model driven engineering and automatic code generation.

WiFiSiM: An Educational Tool for the Study and Design of Wireless Networks

ERIC Educational Resources Information Center

Mateo Sanguino, T. J.; Serrano Lopez, C.; Marquez Hernandez, F. A.

2013-01-01

A new educational simulation tool designed for the generic study of wireless networks, the Wireless Fidelity Simulator (WiFiSim), is presented in this paper. The goal of this work was to create and implement a didactic tool to improve the teaching and learning of computer networks by means of two complementary strategies: simulating the behavior…

Trading Speed and Accuracy by Coding Time: A Coupled-circuit Cortical Model

PubMed Central

Standage, Dominic; You, Hongzhi; Wang, Da-Hui; Dorris, Michael C.

2013-01-01

Our actions take place in space and time, but despite the role of time in decision theory and the growing acknowledgement that the encoding of time is crucial to behaviour, few studies have considered the interactions between neural codes for objects in space and for elapsed time during perceptual decisions. The speed-accuracy trade-off (SAT) provides a window into spatiotemporal interactions. Our hypothesis is that temporal coding determines the rate at which spatial evidence is integrated, controlling the SAT by gain modulation. Here, we propose that local cortical circuits are inherently suited to the relevant spatial and temporal coding. In simulations of an interval estimation task, we use a generic local-circuit model to encode time by ‘climbing’ activity, seen in cortex during tasks with a timing requirement. The model is a network of simulated pyramidal cells and inhibitory interneurons, connected by conductance synapses. A simple learning rule enables the network to quickly produce new interval estimates, which show signature characteristics of estimates by experimental subjects. Analysis of network dynamics formally characterizes this generic, local-circuit timing mechanism. In simulations of a perceptual decision task, we couple two such networks. Network function is determined only by spatial selectivity and NMDA receptor conductance strength; all other parameters are identical. To trade speed and accuracy, the timing network simply learns longer or shorter intervals, driving the rate of downstream decision processing by spatially non-selective input, an established form of gain modulation. Like the timing network's interval estimates, decision times show signature characteristics of those by experimental subjects. Overall, we propose, demonstrate and analyse a generic mechanism for timing, a generic mechanism for modulation of decision processing by temporal codes, and we make predictions for experimental verification. PMID:23592967

Simulation of Quantum Many-Body Dynamics for Generic Strongly-Interacting Systems

NASA Astrophysics Data System (ADS)

Meyer, Gregory; Machado, Francisco; Yao, Norman

2017-04-01

Recent experimental advances have enabled the bottom-up assembly of complex, strongly interacting quantum many-body systems from individual atoms, ions, molecules and photons. These advances open the door to studying dynamics in isolated quantum systems as well as the possibility of realizing novel out-of-equilibrium phases of matter. Numerical studies provide insight into these systems; however, computational time and memory usage limit common numerical methods such as exact diagonalization to relatively small Hilbert spaces of dimension 215 . Here we present progress toward a new software package for dynamical time evolution of large generic quantum systems on massively parallel computing architectures. By projecting large sparse Hamiltonians into a much smaller Krylov subspace, we are able to compute the evolution of strongly interacting systems with Hilbert space dimension nearing 230. We discuss and benchmark different design implementations, such as matrix-free methods and GPU based calculations, using both pre-thermal time crystals and the Sachdev-Ye-Kitaev model as examples. We also include a simple symbolic language to describe generic Hamiltonians, allowing simulation of diverse quantum systems without any modification of the underlying C and Fortran code.

Automating Embedded Analysis Capabilities and Managing Software Complexity in Multiphysics Simulation, Part II: Application to Partial Differential Equations

DOE PAGES

Pawlowski, Roger P.; Phipps, Eric T.; Salinger, Andrew G.; ...

2012-01-01

A template-based generic programming approach was presented in Part I of this series of papers [Sci. Program. 20 (2012), 197–219] that separates the development effort of programming a physical model from that of computing additional quantities, such as derivatives, needed for embedded analysis algorithms. In this paper, we describe the implementation details for using the template-based generic programming approach for simulation and analysis of partial differential equations (PDEs). We detail several of the hurdles that we have encountered, and some of the software infrastructure developed to overcome them. We end with a demonstration where we present shape optimization and uncertaintymore » quantification results for a 3D PDE application.« less

Benefits Assessment of Algorithmically Combining Generic High Altitude Airspace Sectors

NASA Technical Reports Server (NTRS)

Bloem, Michael; Gupta, Pramod; Lai, Chok Fung; Kopardekar, Parimal

2009-01-01

In today's air traffic control operations, sectors that have traffic demand below capacity are combined so that fewer controller teams are required to manage air traffic. Controllers in current operations are certified to control a group of six to eight sectors, known as an area of specialization. Sector combinations are restricted to occur within areas of specialization. Since there are few sector combination possibilities in each area of specialization, human supervisors can effectively make sector combination decisions. In the future, automation and procedures will allow any appropriately trained controller to control any of a large set of generic sectors. The primary benefit of this will be increased controller staffing flexibility. Generic sectors will also allow more options for combining sectors, making sector combination decisions difficult for human supervisors. A sector-combining algorithm can assist supervisors as they make generic sector combination decisions. A heuristic algorithm for combining under-utilized air space sectors to conserve air traffic control resources has been described and analyzed. Analysis of the algorithm and comparisons with operational sector combinations indicate that this algorithm could more efficiently utilize air traffic control resources than current sector combinations. This paper investigates the benefits of using the sector-combining algorithm proposed in previous research to combine high altitude generic airspace sectors. Simulations are conducted in which all the high altitude sectors in a center are allowed to combine, as will be possible in generic high altitude airspace. Furthermore, the algorithm is adjusted to use a version of the simplified dynamic density (SDD) workload metric that has been modified to account for workload reductions due to automatic handoffs and Automatic Dependent Surveillance Broadcast (ADS-B). This modified metric is referred to here as future simplified dynamic density (FSDD). Finally, traffic demand sets with increased air traffic demand are used in the simulations to capture the expected growth in air traffic demand by the mid-term.

Characterization and Compensation of Network-Level Anomalies in Mixed-Signal Neuromorphic Modeling Platforms

PubMed Central

Petrovici, Mihai A.; Vogginger, Bernhard; Müller, Paul; Breitwieser, Oliver; Lundqvist, Mikael; Muller, Lyle; Ehrlich, Matthias; Destexhe, Alain; Lansner, Anders; Schüffny, René; Schemmel, Johannes; Meier, Karlheinz

2014-01-01

Advancing the size and complexity of neural network models leads to an ever increasing demand for computational resources for their simulation. Neuromorphic devices offer a number of advantages over conventional computing architectures, such as high emulation speed or low power consumption, but this usually comes at the price of reduced configurability and precision. In this article, we investigate the consequences of several such factors that are common to neuromorphic devices, more specifically limited hardware resources, limited parameter configurability and parameter variations due to fixed-pattern noise and trial-to-trial variability. Our final aim is to provide an array of methods for coping with such inevitable distortion mechanisms. As a platform for testing our proposed strategies, we use an executable system specification (ESS) of the BrainScaleS neuromorphic system, which has been designed as a universal emulation back-end for neuroscientific modeling. We address the most essential limitations of this device in detail and study their effects on three prototypical benchmark network models within a well-defined, systematic workflow. For each network model, we start by defining quantifiable functionality measures by which we then assess the effects of typical hardware-specific distortion mechanisms, both in idealized software simulations and on the ESS. For those effects that cause unacceptable deviations from the original network dynamics, we suggest generic compensation mechanisms and demonstrate their effectiveness. Both the suggested workflow and the investigated compensation mechanisms are largely back-end independent and do not require additional hardware configurability beyond the one required to emulate the benchmark networks in the first place. We hereby provide a generic methodological environment for configurable neuromorphic devices that are targeted at emulating large-scale, functional neural networks. PMID:25303102

Characterization and compensation of network-level anomalies in mixed-signal neuromorphic modeling platforms.

PubMed

Petrovici, Mihai A; Vogginger, Bernhard; Müller, Paul; Breitwieser, Oliver; Lundqvist, Mikael; Muller, Lyle; Ehrlich, Matthias; Destexhe, Alain; Lansner, Anders; Schüffny, René; Schemmel, Johannes; Meier, Karlheinz

2014-01-01

Advancing the size and complexity of neural network models leads to an ever increasing demand for computational resources for their simulation. Neuromorphic devices offer a number of advantages over conventional computing architectures, such as high emulation speed or low power consumption, but this usually comes at the price of reduced configurability and precision. In this article, we investigate the consequences of several such factors that are common to neuromorphic devices, more specifically limited hardware resources, limited parameter configurability and parameter variations due to fixed-pattern noise and trial-to-trial variability. Our final aim is to provide an array of methods for coping with such inevitable distortion mechanisms. As a platform for testing our proposed strategies, we use an executable system specification (ESS) of the BrainScaleS neuromorphic system, which has been designed as a universal emulation back-end for neuroscientific modeling. We address the most essential limitations of this device in detail and study their effects on three prototypical benchmark network models within a well-defined, systematic workflow. For each network model, we start by defining quantifiable functionality measures by which we then assess the effects of typical hardware-specific distortion mechanisms, both in idealized software simulations and on the ESS. For those effects that cause unacceptable deviations from the original network dynamics, we suggest generic compensation mechanisms and demonstrate their effectiveness. Both the suggested workflow and the investigated compensation mechanisms are largely back-end independent and do not require additional hardware configurability beyond the one required to emulate the benchmark networks in the first place. We hereby provide a generic methodological environment for configurable neuromorphic devices that are targeted at emulating large-scale, functional neural networks.

Effects of an e-Prescribing interface redesign on rates of generic drug prescribing: exploiting default options.

PubMed

Malhotra, Sameer; Cheriff, Adam D; Gossey, J Travis; Cole, Curtis L; Kaushal, Rainu; Ancker, Jessica S

2016-09-01

Increasing the use of generic medications could help control medical costs. However, educational interventions have limited impact on prescriber behavior, and e-prescribing alerts are associated with high override rates and alert fatigue. Our objective was to evaluate the effect of a less intrusive intervention, a redesign of an e-prescribing interface that provides default options intended to "nudge" prescribers towards prescribing generic drugs. This retrospective cohort study in an academic ambulatory multispecialty practice assessed the effects of customizing an e-prescribing interface to substitute generic equivalents for brand-name medications during order entry and allow a one-click override to order the brand-name medication. Among drugs with generic equivalents, the proportion of generic drugs prescribed more than doubled after the interface redesign, rising abruptly from 39.7% to 95.9% (a 56.2% increase; 95% confidence interval, 56.0-56.4%; P < .001). Before the redesign, generic drug prescribing rates varied by therapeutic class, with rates as low as 8.6% for genitourinary products and 15.7% for neuromuscular drugs. After the redesign, generic drug prescribing rates for all but four therapeutic classes were above 90%: endocrine drugs, neuromuscular drugs, nutritional products, and miscellaneous products. Changing the default option in an e-prescribing interface in an ambulatory care setting was followed by large and sustained increases in the proportion of generic drugs prescribed at the practice. Default options in health information technology exert a powerful effect on user behavior, an effect that can be leveraged to optimize decision making. © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Strategic Mobility 21: Modeling, Simulation, and Analysis

DTIC Science & Technology

2010-04-14

using AnyLogic , which is a Java programmed, multi-method simulation modeling tool developed by XJ Technologies. The last section examines the academic... simulation model from an Arena platform to an AnyLogic based Web Service. MATLAB is useful for small problems with few nodes, but GAMS/CPLEX is better... Transportation Modeling Studio TM . The SCASN modeling and simulation program was designed to be generic in nature to allow for use by both commercial and

Research on an expert system for database operation of simulation-emulation math models. Volume 2, Phase 1: Results

NASA Technical Reports Server (NTRS)

Kawamura, K.; Beale, G. O.; Schaffer, J. D.; Hsieh, B. J.; Padalkar, S.; Rodriguez-Moscoso, J. J.

1985-01-01

A reference manual is provided for NESS, a simulation expert system. This manual gives user information regarding starting and operating NASA expert simulation system (NESS). This expert system provides an intelligent interface to a generic simulation program for spacecraft attitude control problems. A menu of the functions the system can perform is provided. Control repeated returns to this menu after executing each user request.

Interservice/Industry Training, Simulation and Education Conference Partnerships for Learning in the New Millennium Abstracts

DTIC Science & Technology

2000-01-01

for flight test data, and both generic and specialized tools of data filtering , data calibration, modeling , system identification, and simulation...GRAMMATICAL MODEL AND PARSER FOR AIR TRAFFIC CONTROLLER’S COMMANDS 11 A SPEECH-CONTROLLED INTERACTIVE VIRTUAL ENVIRONMENT FOR SHIP FAMILIARIZATION 12... MODELING AND SIMULATION IN THE 21ST CENTURY 23 NEW COTS HARDWARE AND SOFTWARE REDUCE THE COST AND EFFORT IN REPLACING AGING FLIGHT SIMULATORS SUBSYSTEMS

Descriptive Model of Generic WAMS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hauer, John F.; DeSteese, John G.

The Department of Energy’s (DOE) Transmission Reliability Program is supporting the research, deployment, and demonstration of various wide area measurement system (WAMS) technologies to enhance the reliability of the Nation’s electrical power grid. Pacific Northwest National Laboratory (PNNL) was tasked by the DOE National SCADA Test Bed Program to conduct a study of WAMS security. This report represents achievement of the milestone to develop a generic WAMS model description that will provide a basis for the security analysis planned in the next phase of this study.

47 CFR 51.231 - Provision of information on advanced services deployment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the requesting carrier asserts that the technology it seeks to deploy fits within a generic power... technology, it must provide the incumbent LEC with information on the speed and power at which the signal... rejection; and (3) Information with respect to the number of loops using advanced services technology within...

78 FR 37324 - Preparation of Environmental Reports for Nuclear Power Plant License Renewal Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... Commission's 1996 findings on the environmental impacts of renewing the operating license of a nuclear power.... Specifically, the final rule amends Table B-1 by redefining the number and scope of the environmental impact... is publishing Revision 1 to NUREG-1437, ``Generic Environmental Impact Statement for License Renewal...

75 FR 11578 - Northern States Power Company of Minnesota, Monticello Nuclear Generating Plant; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... generically extend the rule's compliance date for all operating nuclear power plants, but noted that the..., Nuclear Energy Institute). The licensee's request for an exemption is, therefore, consistent with the... Commission (NRC, the Commission) now or hereafter in effect. The facility consists of a General Electric...

Performance of comorbidity, risk adjustment, and functional status measures in expenditure prediction for patients with diabetes.

PubMed

Maciejewski, Matthew L; Liu, Chuan-Fen; Fihn, Stephan D

2009-01-01

To compare the ability of generic comorbidity and risk adjustment measures, a diabetes-specific measure, and a self-reported functional status measure to explain variation in health care expenditures for individuals with diabetes. This study included a retrospective cohort of 3,092 diabetic veterans participating in a multisite trial. Two comorbidity measures, four risk adjusters, a functional status measure, a diabetes complication count, and baseline expenditures were constructed from administrative and survey data. Outpatient, inpatient, and total expenditure models were estimated using ordinary least squares regression. Adjusted R(2) statistics and predictive ratios were compared across measures to assess overall explanatory power and explanatory power of low- and high-cost subgroups. Administrative data-based risk adjusters performed better than the comorbidity, functional status, and diabetes-specific measures in all expenditure models. The diagnostic cost groups (DCGs) measure had the greatest predictive power overall and for the low- and high-cost subgroups, while the diabetes-specific measure had the lowest predictive power. A model with DCGs and the diabetes-specific measure modestly improved predictive power. Existing generic measures can be useful for diabetes-specific research and policy applications, but more predictive diabetes-specific measures are needed.

G STL: the geostatistical template library in C++

NASA Astrophysics Data System (ADS)

Remy, Nicolas; Shtuka, Arben; Levy, Bruno; Caers, Jef

2002-10-01

The development of geostatistics has been mostly accomplished by application-oriented engineers in the past 20 years. The focus on concrete applications gave birth to many algorithms and computer programs designed to address different issues, such as estimating or simulating a variable while possibly accounting for secondary information such as seismic data, or integrating geological and geometrical data. At the core of any geostatistical data integration methodology is a well-designed algorithm. Yet, despite their obvious differences, all these algorithms share many commonalities on which to build a geostatistics programming library, lest the resulting library is poorly reusable and difficult to expand. Building on this observation, we design a comprehensive, yet flexible and easily reusable library of geostatistics algorithms in C++. The recent advent of the generic programming paradigm allows us elegantly to express the commonalities of the geostatistical algorithms into computer code. Generic programming, also referred to as "programming with concepts", provides a high level of abstraction without loss of efficiency. This last point is a major gain over object-oriented programming which often trades efficiency for abstraction. It is not enough for a numerical library to be reusable, it also has to be fast. Because generic programming is "programming with concepts", the essential step in the library design is the careful identification and thorough definition of these concepts shared by most geostatistical algorithms. Building on these definitions, a generic and expandable code can be developed. To show the advantages of such a generic library, we use G STL to build two sequential simulation programs working on two different types of grids—a surface with faults and an unstructured grid—without requiring any change to the G STL code.

Mutually cooperative epidemics on power-law networks

NASA Astrophysics Data System (ADS)

Cui, Peng-Bi; Colaiori, Francesca; Castellano, Claudio

2017-08-01

The spread of an infectious disease can, in some cases, promote the propagation of other pathogens favoring violent outbreaks, which cause a discontinuous transition to an endemic state. The topology of the contact network plays a crucial role in these cooperative dynamics. We consider a susceptible-infected-removed-type model with two mutually cooperative pathogens: An individual already infected with one disease has an increased probability of getting infected by the other. We present a heterogeneous mean-field theoretical approach to the coinfection dynamics on generic uncorrelated power-law degree-distributed networks and validate its results by means of numerical simulations. We show that, when the second moment of the degree distribution is finite, the epidemic transition is continuous for low cooperativity, while it is discontinuous when cooperativity is sufficiently high. For scale-free networks, i.e., topologies with diverging second moment, the transition is instead always continuous. In this way we clarify the effect of heterogeneity and system size on the nature of the transition, and we validate the physical interpretation about the origin of the discontinuity.

Universal scaling relations in scale-free structure formation

NASA Astrophysics Data System (ADS)

Guszejnov, Dávid; Hopkins, Philip F.; Grudić, Michael Y.

2018-07-01

A large number of astronomical phenomena exhibit remarkably similar scaling relations. The most well-known of these is the mass distribution dN/dM ∝ M-2 which (to first order) describes stars, protostellar cores, clumps, giant molecular clouds, star clusters, and even dark matter haloes. In this paper we propose that this ubiquity is not a coincidence and that it is the generic result of scale-free structure formation where the different scales are uncorrelated. We show that all such systems produce a mass function proportional to M-2 and a column density distribution with a power-law tail of dA/dln Σ ∝ Σ-1. In the case where structure formation is controlled by gravity the two-point correlation becomes ξ2D ∝ R-1. Furthermore, structures formed by such processes (e.g. young star clusters, DM haloes) tend to a ρ ∝ R-3 density profile. We compare these predictions with observations, analytical fragmentation cascade models, semi-analytical models of gravito-turbulent fragmentation, and detailed `full physics' hydrodynamical simulations. We find that these power laws are good first-order descriptions in all cases.

Spatial solitons and stability in the one-dimensional and the two-dimensional generalized nonlinear Schrödinger equation with fourth-order diffraction and parity-time-symmetric potentials

NASA Astrophysics Data System (ADS)

Tiofack, C. G. L.; Ndzana, F., II; Mohamadou, A.; Kofane, T. C.

2018-03-01

We investigate the existence and stability of solitons in parity-time (PT )-symmetric optical media characterized by a generic complex hyperbolic refractive index distribution and fourth-order diffraction (FOD). For the linear case, we demonstrate numerically that the FOD parameter can alter the PT -breaking points. For nonlinear cases, the exact analytical expressions of the localized modes are obtained both in one- and two-dimensional nonlinear Schrödinger equations with self-focusing and self-defocusing Kerr nonlinearity. The effect of FOD on the stability structure of these localized modes is discussed with the help of linear stability analysis followed by the direct numerical simulation of the governing equation. Examples of stable and unstable solutions are given. The transverse power flow density associated with these localized modes is also discussed. It is found that the relative strength of the FOD coefficient can utterly change the direction of the power flow, which may be used to control the energy exchange among gain or loss regions.

Universal Scaling Relations in Scale-Free Structure Formation

NASA Astrophysics Data System (ADS)

Guszejnov, Dávid; Hopkins, Philip F.; Grudić, Michael Y.

2018-04-01

A large number of astronomical phenomena exhibit remarkably similar scaling relations. The most well-known of these is the mass distribution dN/dM∝M-2 which (to first order) describes stars, protostellar cores, clumps, giant molecular clouds, star clusters and even dark matter halos. In this paper we propose that this ubiquity is not a coincidence and that it is the generic result of scale-free structure formation where the different scales are uncorrelated. We show that all such systems produce a mass function proportional to M-2 and a column density distribution with a power law tail of dA/d lnΣ∝Σ-1. In the case where structure formation is controlled by gravity the two-point correlation becomes ξ2D∝R-1. Furthermore, structures formed by such processes (e.g. young star clusters, DM halos) tend to a ρ∝R-3 density profile. We compare these predictions with observations, analytical fragmentation cascade models, semi-analytical models of gravito-turbulent fragmentation and detailed "full physics" hydrodynamical simulations. We find that these power-laws are good first order descriptions in all cases.

Searching for gravitational waves from compact binaries with precessing spins

NASA Astrophysics Data System (ADS)

Harry, Ian; Privitera, Stephen; Bohé, Alejandro; Buonanno, Alessandra

2016-07-01

Current searches for gravitational waves from compact-object binaries with the LIGO and Virgo observatories employ waveform models with spins aligned (or antialigned) with the orbital angular momentum. Here, we derive a new statistic to search for compact objects carrying generic (precessing) spins. Applying this statistic, we construct banks of both aligned- and generic-spin templates for binary black holes and neutron star-black hole binaries, and compare the effectualness of these banks towards simulated populations of generic-spin systems. We then use these banks in a pipeline analysis of Gaussian noise to measure the increase in background incurred by using generic- instead of aligned-spin banks. Although the generic-spin banks have roughly a factor of ten more templates than the aligned-spin banks, we find an overall improvement in signal recovery at a fixed false-alarm rate for systems with high-mass ratio and highly precessing spins. This gain in sensitivity comes at a small loss of sensitivity (≲4 %) for systems that are already well covered by aligned-spin templates. Since the observation of even a single binary merger with misaligned spins could provide unique astrophysical insights into the formation of these sources, we recommend that the method described here be developed further to mount a viable search for generic-spin binary mergers in LIGO/Virgo data.

Integrated dynamic analysis simulation of space stations with controllable solar arrays (supplemental data and analyses)

NASA Technical Reports Server (NTRS)

Heinrichs, J. A.; Fee, J. J.

1972-01-01

Space station and solar array data and the analyses which were performed in support of the integrated dynamic analysis study. The analysis methods and the formulated digital simulation were developed. Control systems for space station altitude control and solar array orientation control include generic type control systems. These systems have been digitally coded and included in the simulation.

The KATE shell: An implementation of model-based control, monitor and diagnosis

NASA Technical Reports Server (NTRS)

Cornell, Matthew

1987-01-01

The conventional control and monitor software currently used by the Space Center for Space Shuttle processing has many limitations such as high maintenance costs, limited diagnostic capabilities and simulation support. These limitations have caused the development of a knowledge based (or model based) shell to generically control and monitor electro-mechanical systems. The knowledge base describes the system's structure and function and is used by a software shell to do real time constraints checking, low level control of components, diagnosis of detected faults, sensor validation, automatic generation of schematic diagrams and automatic recovery from failures. This approach is more versatile and more powerful than the conventional hard coded approach and offers many advantages over it, although, for systems which require high speed reaction times or aren't well understood, knowledge based control and monitor systems may not be appropriate.

Anomalous critical slowdown at a first order phase transition in single polymer chains.

PubMed

Zhang, Shuangshuang; Qi, Shuanhu; Klushin, Leonid I; Skvortsov, Alexander M; Yan, Dadong; Schmid, Friederike

2017-08-14

Using Brownian dynamics, we study the dynamical behavior of a polymer grafted onto an adhesive surface close to the mechanically induced adsorption-stretching transition. Even though the transition is first order (in the infinite chain length limit, the stretching degree of the chain jumps discontinuously), the characteristic relaxation time is found to grow according to a power law as the transition point is approached. We present a dynamic effective interface model which reproduces these observations and provides an excellent quantitative description of the simulation data. The generic nature of the theoretical model suggests that the unconventional mixing of features that are characteristic for first-order transitions (a jump in an order parameter) and features that are characteristic of critical points (an anomalous slowdown) may be a common phenomenon in force-driven phase transitions of macromolecules.

Impact of network structure on the capacity of wireless multihop ad hoc communication

NASA Astrophysics Data System (ADS)

Krause, Wolfram; Glauche, Ingmar; Sollacher, Rudolf; Greiner, Martin

2004-07-01

As a representative of a complex technological system, the so-called wireless multihop ad hoc communication networks are discussed. They represent an infrastructure-less generalization of todays wireless cellular phone networks. Lacking a central control authority, the ad hoc nodes have to coordinate themselves such that the overall network performs in an optimal way. A performance indicator is the end-to-end throughput capacity. Various models, generating differing ad hoc network structure via differing transmission power assignments, are constructed and characterized. They serve as input for a generic data traffic simulation as well as some semi-analytic estimations. The latter reveal that due to the most-critical-node effect the end-to-end throughput capacity sensitively depends on the underlying network structure, resulting in differing scaling laws with respect to network size.

Numerical Simulations on the Laser Spot Welding of Zirconium Alloy Endplate for Nuclear Fuel Bundle Assembly

NASA Astrophysics Data System (ADS)

Satyanarayana, G.; Narayana, K. L.; Boggarapu, Nageswara Rao

2018-03-01

In the nuclear industry, a critical welding process is joining of an end plate to a fuel rod to form a fuel bundle. Literature on zirconium welding in such a critical operation is limited. A CFD model is developed and performed for the three-dimensional non-linear thermo-fluid analysis incorporating buoyancy and Marnangoni stress and specifying temperature dependent properties to predict weld geometry and temperature field in and around the melt pool of laser spot during welding of a zirconium alloy E110 endplate with a fuel rod. Using this method, it is possible to estimate the weld pool dimensions for the specified laser power and laser-on-time. The temperature profiles will estimate the HAZ and microstructure. The adequacy of generic nature of the model is validated with existing experimental data.

PTBS segmentation scheme for synthetic aperture radar

NASA Astrophysics Data System (ADS)

Friedland, Noah S.; Rothwell, Brian J.

1995-07-01

The Image Understanding Group at Martin Marietta Technologies in Denver, Colorado has developed a model-based synthetic aperture radar (SAR) automatic target recognition (ATR) system using an integrated resource architecture (IRA). IRA, an adaptive Markov random field (MRF) environment, utilizes information from image, model, and neighborhood resources to create a discrete, 2D feature-based world description (FBWD). The IRA FBWD features are peak, target, background and shadow (PTBS). These features have been shown to be very useful for target discrimination. The FBWD is used to accrue evidence over a model hypothesis set. This paper presents the PTBS segmentation process utilizing two IRA resources. The image resource (IR) provides generic (the physics of image formation) and specific (the given image input) information. The neighborhood resource (NR) provides domain knowledge of localized FBWD site behaviors. A simulated annealing optimization algorithm is used to construct a `most likely' PTBS state. Results on simulated imagery illustrate the power of this technique to correctly segment PTBS features, even when vehicle signatures are immersed in heavy background clutter. These segmentations also suppress sidelobe effects and delineate shadows.

Workshop on environmental qualification of electric equipment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lofaro, R.; Gunther, W.; Villaran, M.

1994-05-01

Questions concerning the Environmental Qualification (EQ) of electrical equipment used in commercial nuclear power plants have recently become the subject of significant interest to the US Nuclear Regulatory Commission (NRC). Initial questions centered on whether compliance with the EQ requirements for older plants were adequate to support plant operation beyond 40 years. After subsequent investigation, the NRC Staff concluded that questions related to the differences in EQ requirements between older and newer plants constitute a potential generic issue which should be evaluated for backfit, independent of license renewal activities. EQ testing of electric cables was performed by Sandia National Laboratoriesmore » (SNL) under contract to the NRC in support of license renewal activities. Results showed that some of the environmentally qualified cables either failed or exhibited marginal insulation resistance after a simulated plant life of 20 years during accident simulation. This indicated that the EQ process for some electric cables may be non-conservative. These results raised questions regarding the EQ process including the bases for conclusions about the qualified life of components based upon artificial aging prior to testing.« less

Evolution of the magnetorotational instability on initially tangled magnetic fields

NASA Astrophysics Data System (ADS)

Bhat, Pallavi; Ebrahimi, Fatima; Blackman, Eric G.; Subramanian, Kandaswamy

2017-12-01

The initial magnetic field of previous magnetorotational instability (MRI) simulations has always included a significant system-scale component, even if stochastic. However, it is of conceptual and practical interest to assess whether the MRI can grow when the initial field is turbulent. The ubiquitous presence of turbulent or random flows in astrophysical plasmas generically leads to a small-scale dynamo (SSD), which would provide initial seed turbulent velocity and magnetic fields in the plasma that becomes an accretion disc. Can the MRI grow from these more realistic initial conditions? To address this, we supply a standard shearing box with isotropically forced SSD generated magnetic and velocity fields as initial conditions and remove the forcing. We find that if the initially supplied fields are too weak or too incoherent, they decay from the initial turbulent cascade faster than they can grow via the MRI. When the initially supplied fields are sufficient to allow MRI growth and sustenance, the saturated stresses, large-scale fields and power spectra match those of the standard zero net flux MRI simulation with an initial large-scale vertical field.

Forecasting fluid milk and cheese demands for the next decade.

PubMed

Schmit, T M; Kaiser, H M

2006-12-01

Predictions of future market demands and farm prices for dairy products are important determinants in developing marketing strategies and farm-production planning decisions. The objective of this report was to use current aggregate forecast data, combined with existing econometric models of demand and supply, to forecast retail demands for fluid milk and cheese and the supply and price of farm milk over the next decade. In doing so, we can investigate whether projections of population and consumer food-spending patterns will extend or alter current consumption trends and examine the implications of future generic advertising strategies for dairy products. To conduct the forecast simulations and appropriately allocate the farm milk supply to various uses, we used a partial equilibrium model of the US domestic dairy sector that segmented the industry into retail, wholesale, and farm markets. Model simulation results indicated that declines in retail per capita demand would persist but at a reduced rate from years past and that retail per capita demand for cheese would continue to grow and strengthen over the next decade. These predictions rely on expected changes in the size of populations of various ages, races, and ethnicities and on existing patterns of spending on food at home and away from home. The combined effect of these forecasted changes in demand levels was reflected in annualized growth in the total farm-milk supply that was similar to growth realized during the past few years. Although we expect nominal farm milk prices to increase over the next decade, we expect real prices (relative to assumed growth in feed costs) to remain relatively stable and show no increase until the end of the forecast period. Supplemental industry model simulations also suggested that net losses in producer revenues would result if only nominal levels of generic advertising spending were maintained in forthcoming years. In fact, if real generic advertising expenditures are increased relative to 2005 levels, returns to the investment in generic advertising can be improved. Specifically, each additional real dollar invested in generic advertising for fluid milk and cheese products over the forecast period would result in an additional 5.61 dollars in producer revenues.

Energy efficiency evaluation of a stationary lithium-ion battery container storage system via electro-thermal modeling and detailed component analysis

DOE PAGES

Schimpe, Michael; Naumann, Maik; Truong, Nam; ...

2017-11-08

Energy efficiency is a key performance indicator for battery storage systems. A detailed electro-thermal model of a stationary lithium-ion battery system is developed and an evaluation of its energy efficiency is conducted. The model offers a holistic approach to calculating conversion losses and auxiliary power consumption. Sub-models for battery rack, power electronics, thermal management as well as the control and monitoring components are developed and coupled to a comprehensive model. The simulation is parametrized based on a prototype 192 kWh system using lithium iron phosphate batteries connected to the low voltage grid. The key loss mechanisms are identified, thoroughly analyzedmore » and modeled. Generic profiles featuring various system operation modes are evaluated to show the characteristics of stationary battery systems. Typically the losses in the power electronics outweigh the losses in the battery at low power operating points. The auxiliary power consumption dominates for low system utilization rates. For estimation of real-world performance, the grid applications Primary Control Reserve, Secondary Control Reserve and the storage of surplus photovoltaic power are evaluated. Conversion round-trip efficiency is in the range of 70-80%. Finally, overall system efficiency, which also considers system power consumption, is 8-13 percentage points lower for Primary Control Reserve and the photovoltaic-battery application. However, for Secondary Control Reserve, the total round-trip efficiency is found to be extremely low at 23% due to the low energy throughput of this application type.« less

Energy efficiency evaluation of a stationary lithium-ion battery container storage system via electro-thermal modeling and detailed component analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schimpe, Michael; Naumann, Maik; Truong, Nam

Energy efficiency is a key performance indicator for battery storage systems. A detailed electro-thermal model of a stationary lithium-ion battery system is developed and an evaluation of its energy efficiency is conducted. The model offers a holistic approach to calculating conversion losses and auxiliary power consumption. Sub-models for battery rack, power electronics, thermal management as well as the control and monitoring components are developed and coupled to a comprehensive model. The simulation is parametrized based on a prototype 192 kWh system using lithium iron phosphate batteries connected to the low voltage grid. The key loss mechanisms are identified, thoroughly analyzedmore » and modeled. Generic profiles featuring various system operation modes are evaluated to show the characteristics of stationary battery systems. Typically the losses in the power electronics outweigh the losses in the battery at low power operating points. The auxiliary power consumption dominates for low system utilization rates. For estimation of real-world performance, the grid applications Primary Control Reserve, Secondary Control Reserve and the storage of surplus photovoltaic power are evaluated. Conversion round-trip efficiency is in the range of 70-80%. Finally, overall system efficiency, which also considers system power consumption, is 8-13 percentage points lower for Primary Control Reserve and the photovoltaic-battery application. However, for Secondary Control Reserve, the total round-trip efficiency is found to be extremely low at 23% due to the low energy throughput of this application type.« less

Passive Sun seeker/tracker and a thermally activated power module

NASA Technical Reports Server (NTRS)

Siebert, C. J.; Morris, F. A.

1984-01-01

Development and testing of two mechanisms using a shape memory alloy metal (NITINOL) as the power source are described. The two mechanisms developed are a passive Sun Seeker/Tracker and a generic type power module. These mechanisms use NITINOL wire initially strained in pure torsion which provides the greatest mechanical work capacity upon recovery, as compared to other deformation modes (i.e., tension, helical springs, and bending).

Modeling HIV/AIDS Drug Price Determinants in Brazil: Is Generic Competition a Myth?

PubMed Central

Meiners, Constance; Sagaon-Teyssier, Luis; Hasenclever, Lia; Moatti, Jean-Paul

2011-01-01

Background Brazil became the first developing country to guarantee free and universal access to HIV/AIDS treatment, with antiretroviral drugs (ARVs) being delivered to nearly 190,000 patients. The analysis of ARV price evolution and market dynamics in Brazil can help anticipate issues soon to afflict other developing countries, as the 2010 revision of the World Health Organization guidelines shifts demand towards more expensive treatments, and, at the same time, current evolution of international legislation and trade agreements on intellectual property rights may reduce availability of generic drugs for HIV care. Methods and Findings Our analyses are based on effective prices paid for ARV procurement in Brazil between 1996 and 2009. Data panel structure was exploited to gather ex-ante and ex-post information and address various sources of statistical bias. In-difference estimation offered in-depth information on ARV market characteristics which significantly influence prices. Although overall ARV prices follow a declining trend, changing characteristics in the generic segment help explain recent increase in generic ARV prices. Our results show that generic suppliers are more likely to respond to factors influencing demand size and market competition, while originator suppliers tend to set prices strategically to offset compulsory licensing threats and generic competition. Significance In order to guarantee the long term sustainability of access to antiretroviral treatment, our findings highlight the importance of preserving and stimulating generic market dynamics to sustain developing countries' bargaining power in price negotiations undertaken with originator companies. PMID:21858138

Modeling HIV/AIDS drug price determinants in Brazil: is generic competition a myth?

PubMed

Meiners, Constance; Sagaon-Teyssier, Luis; Hasenclever, Lia; Moatti, Jean-Paul

2011-01-01

Brazil became the first developing country to guarantee free and universal access to HIV/AIDS treatment, with antiretroviral drugs (ARVs) being delivered to nearly 190,000 patients. The analysis of ARV price evolution and market dynamics in Brazil can help anticipate issues soon to afflict other developing countries, as the 2010 revision of the World Health Organization guidelines shifts demand towards more expensive treatments, and, at the same time, current evolution of international legislation and trade agreements on intellectual property rights may reduce availability of generic drugs for HIV care. Our analyses are based on effective prices paid for ARV procurement in Brazil between 1996 and 2009. Data panel structure was exploited to gather ex-ante and ex-post information and address various sources of statistical bias. In-difference estimation offered in-depth information on ARV market characteristics which significantly influence prices. Although overall ARV prices follow a declining trend, changing characteristics in the generic segment help explain recent increase in generic ARV prices. Our results show that generic suppliers are more likely to respond to factors influencing demand size and market competition, while originator suppliers tend to set prices strategically to offset compulsory licensing threats and generic competition. In order to guarantee the long term sustainability of access to antiretroviral treatment, our findings highlight the importance of preserving and stimulating generic market dynamics to sustain developing countries' bargaining power in price negotiations undertaken with originator companies.

A Generic Mesh Data Structure with Parallel Applications

ERIC Educational Resources Information Center

Cochran, William Kenneth, Jr.

2009-01-01

High performance, massively-parallel multi-physics simulations are built on efficient mesh data structures. Most data structures are designed from the bottom up, focusing on the implementation of linear algebra routines. In this thesis, we explore a top-down approach to design, evaluating the various needs of many aspects of simulation, not just…

Solar Array Power Conditioning for a Spinning Satellite

NASA Astrophysics Data System (ADS)

De Luca, Antonio; Chirulli, Giovanni

2008-09-01

The conditioning of the output power from a solar array can mainly be achieved by the adoption of DET or MPPT based architecture. There are several factors that can orientate the choice of the system designer towards one solution or the other; some of them maybe inherent to the mission derived requirements (Illumination levels, EMC cleanliness, etc.), others come directly from a careful assessment of performances and losses of both power conditioner and solar array.Definition of the criteria on which basis the final choice is justified is important as they have to guarantee a clear determination of the available versus the required power in all those mission conditions identifiable as design drivers for the overall satellite system both in terms of mass and costs.Such criteria cannot just be simple theoretical enunciations of principles; nor the meticulous definition of them on a case by case basis for different types of missions as neither option gives a guarantee of being conclusive.The aim of this paper is then to suggest assessment steps and guidelines that can be considered generically valid for any mission case, starting from the exposition of the trade off activity performed in order to choose the power conditioning solution for a spinning satellite having unregulated power bus architecture. Calculations and numerical simulations have been made in order to establish the needed solar array surface in case of adoption of a DET or MPPT solution, taking into account temperature and illumination levels on the solar cells, as well as power losses and inefficiencies from the solar generator to the main power bus, in different mission phases. Particular attention has been taken in order to correctly evaluate the thermal effects on the rest of the spacecraft as function of the adopted power system regulation.

Wind Power Energy in Southern Brazil: evaluation using a mesoscale meteorological model

NASA Astrophysics Data System (ADS)

Krusche, Nisia; Stoevesandt, Bernhard; Chang, Chi-Yao; Peralta, Carlos

2015-04-01

In recent years, several wind farms were build in the coast of Rio Grande do Sul state. This region of Brazil was identified, in wind energy studies, as most favorable to the development of wind power energy, along with the Northeast part of the country. Site assessments of wind power, over long periods to estimate the power production and forecasts over short periods can be used for planning of power distribution and enhancements on Brazil's present capacity to use this resource. The computational power available today allows the simulation of the atmospheric flow in great detail. For instance, one of the authors participated in a research that demonstrated the interaction between the lake and maritime breeze in this region through the use of a atmospheric model. Therefore, we aim to evaluate simulations of wind conditions and its potential to generate energy in this region. The model applied is the Weather Research and Forecasting , which is the mesoscale weather forecast software. The calculation domain is centered in 32oS and 52oW, in the southern region of Rio Grande do Sul state. The initial conditions of the simulation are taken from the global weather forecast in the time period from October 1st to October 31st, 2006. The wind power potential was calculated for a generic turbine, with a blade length of 52 m, using the expression: P=1/2*d*A*Cp*v^3, where P is the wind power energy (in Watts), d is the density (equal to 1.23 kg/m^3), A is the area section, which is equal to 8500 m2 , and v is the intensity of the velocity. The evaluation was done for a turbine placed at 50 m and 150 m of height. A threshold was chosen for a turbine production of 1.5 MW to estimate the potential of the site. In contrast to northern Brazilian region, which has a rather constant wind condition, this region shows a great variation of power output due to the weather variability. During the period of the study, at least three frontal systems went over the region, and thre was a associated variation of wind intensity. The monthly average indicate several small regions with a higher value of energy. Average production higher than 1.5 MW, for the area inland, was of 72.9% for a turbine at 150 m height but only 13.1% for one at 50 m height. This initial study indicates the variability of the region in terms of wind power availability. It can be extended to the study of extreme situations, as the case of very strong winds that knocked down 8 wind turbines in this region on the 20 of December of 2014. Simulations with high degree of spacial details will be the next step in this investigation.

Intelligent systems approach for automated identification of individual control behavior of a human operator

NASA Astrophysics Data System (ADS)

Zaychik, Kirill B.

Acceptable results have been obtained using conventional techniques to model the generic human operator's control behavior. However, little research has been done in an attempt to identify an individual based on his/her control behavior. The main hypothesis investigated in this dissertation is that different operators exhibit different control behavior when performing a given control task. Furthermore, inter-person differences are manifested in the amplitude and frequency content of the non-linear component of the control behavior. Two enhancements to the existing models of the human operator, which allow personalization of the modeled control behavior, are presented in this dissertation. One of the proposed enhancements accounts for the "testing" control signals, which are introduced by an operator for more accurate control of the system and/or to adjust his/her control strategy. Such enhancement uses the Artificial Neural Network (ANN), which can be fine-tuned to model the "testing" control behavior of a given individual. The other model enhancement took the form of an equiripple filter (EF), which conditions the power spectrum of the control signal before it is passed through the plant dynamics block. The filter design technique uses Parks-McClellan algorithm, which allows parameterization of the desired levels of power at certain frequencies. A novel automated parameter identification technique (APID) was developed to facilitate the identification process of the parameters of the selected models of the human operator. APID utilizes a Genetic Algorithm (GA) based optimization engine called the Bit-climbing Algorithm (BCA). Proposed model enhancements were validated using the experimental data obtained at three different sources: the Manual Control Laboratory software experiments, Unmanned Aerial Vehicle simulation, and NASA Langley Research Center Visual Motion Simulator studies. Validation analysis involves comparison of the actual and simulated control activity signals. Validation criteria used in this dissertation is based on comparing Power Spectral Densities of the control signals against that of the Precision model of the human operator. This dissertation also addresses the issue of applying the proposed human operator model augmentation to evaluate the effectiveness of the motion feedback when simulating the actual pilot control behavior in a flight simulator. The proposed modeling methodology allows for quantitative assessments and prediction of the need for platform motion, while performing aircraft/pilot simulation studies.

Generic solar photovoltaic system dynamic simulation model specification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ellis, Abraham; Behnke, Michael Robert; Elliott, Ryan Thomas

This document is intended to serve as a specification for generic solar photovoltaic (PV) system positive-sequence dynamic models to be implemented by software developers and approved by the WECC MVWG for use in bulk system dynamic simulations in accordance with NERC MOD standards. Two specific dynamic models are included in the scope of this document. The first, a Central Station PV System model, is intended to capture the most important dynamic characteristics of large scale (> 10 MW) PV systems with a central Point of Interconnection (POI) at the transmission level. The second, a Distributed PV System model, is intendedmore » to represent an aggregation of smaller, distribution-connected systems that comprise a portion of a composite load that might be modeled at a transmission load bus.« less

Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 2, Appendices A--L.

DOE Office of Scientific and Technical Information (OSTI.GOV)

United States. Bonneville Power Administration.

1992-01-01

This report consists of appendices A-L of the final environmental impact statement for the Bonneville Power Administration. The appendices provide information on the following: Ninth circuit Court opinion in Forelaws on Board v. Johnson; guide to Northwest Power act contracts; guide to hydro operations; glossary; affected environment supporting documentation; environmental impacts of generic resource types; information on models used; technical information on analysis; public involvement activities; bibliography; Pacific Northwest Electric Power Planning and Conservation Act; and biological assessment. (CBS)

An avionics scenario and command model description for Space Generic Open Avionics Architecture (SGOAA)

NASA Technical Reports Server (NTRS)

Stovall, John R.; Wray, Richard B.

1994-01-01

This paper presents a description of a model for a space vehicle operational scenario and the commands for avionics. This model will be used in developing a dynamic architecture simulation model using the Statemate CASE tool for validation of the Space Generic Open Avionics Architecture (SGOAA). The SGOAA has been proposed as an avionics architecture standard to NASA through its Strategic Avionics Technology Working Group (SATWG) and has been accepted by the Society of Automotive Engineers (SAE) for conversion into an SAE Avionics Standard. This architecture was developed for the Flight Data Systems Division (FDSD) of the NASA Johnson Space Center (JSC) by the Lockheed Engineering and Sciences Company (LESC), Houston, Texas. This SGOAA includes a generic system architecture for the entities in spacecraft avionics, a generic processing external and internal hardware architecture, and a nine class model of interfaces. The SGOAA is both scalable and recursive and can be applied to any hierarchical level of hardware/software processing systems.

75 FR 47856 - Nebraska Public Power District: Cooper Nuclear Station; Notice of Availability of the Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-09

... NUCLEAR REGULATORY COMMISSION [Docket No. 50-298; NRC-2008-0617] Nebraska Public Power District: Cooper Nuclear Station; Notice of Availability of the Final Supplement 41 to the Generic Environmental Impact Statement for License Renewal of Nuclear Plants Notice is hereby given that the U.S. Nuclear Regulatory Commission (NRC, Commission) has...

75 FR 16518 - Florida Power Corporation, et al.; Crystal River Unit 3 Nuclear Generating Plant; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... generically extend the rule's compliance date for all operating nuclear power plants, but noted that the..., Nuclear Energy Institute). The licensee's request for an exemption is therefore consistent with the... of this exemption will not have a significant effect on the quality of the human environment (75 FR...

STDP Installs in Winner-Take-All Circuits an Online Approximation to Hidden Markov Model Learning

PubMed Central

Kappel, David; Nessler, Bernhard; Maass, Wolfgang

2014-01-01

In order to cross a street without being run over, we need to be able to extract very fast hidden causes of dynamically changing multi-modal sensory stimuli, and to predict their future evolution. We show here that a generic cortical microcircuit motif, pyramidal cells with lateral excitation and inhibition, provides the basis for this difficult but all-important information processing capability. This capability emerges in the presence of noise automatically through effects of STDP on connections between pyramidal cells in Winner-Take-All circuits with lateral excitation. In fact, one can show that these motifs endow cortical microcircuits with functional properties of a hidden Markov model, a generic model for solving such tasks through probabilistic inference. Whereas in engineering applications this model is adapted to specific tasks through offline learning, we show here that a major portion of the functionality of hidden Markov models arises already from online applications of STDP, without any supervision or rewards. We demonstrate the emergent computing capabilities of the model through several computer simulations. The full power of hidden Markov model learning can be attained through reward-gated STDP. This is due to the fact that these mechanisms enable a rejection sampling approximation to theoretically optimal learning. We investigate the possible performance gain that can be achieved with this more accurate learning method for an artificial grammar task. PMID:24675787

Satellite Power System (SPS). State and local regulations as applied to satellite power system microwave receiving antenna facilities

NASA Technical Reports Server (NTRS)

Kotin, A. D.

1978-01-01

State and local regulation of power plant construction and operation of solar power satellite (SPS) receiving stations is presented. Each receiving antenna station occupies a land area 100-200 km square, receives microwave transmissions from the solar power satellite, and converts them into electricity for transmission to the power grid. The long lead time associated with the SPS and the changing status of state and local regulation dictated emphasis on: generic classification of the types of regulation, and identification of regulatory vectors which affect rectenna facilities.

Model-based diagnostics of gas turbine engine lubrication systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Byington, C.S.

1998-09-01

The objective of the current research was to develop improved methodology for diagnosing anomalies and maintaining oil lubrication systems for gas turbine engines. The effort focused on the development of reasoning modules that utilize the existing, inexpensive sensors and are applicable to on-line monitoring within the full-authority digital engine controller (FADEC) of the engine. The target application is the Enhanced TF-40B gas turbine engine that powers the Landing Craft Air Cushion (LCAC) platform. To accomplish the development of the requisite data fusion algorithms and automated reasoning for the diagnostic modules, Penn State ARL produced a generic Turbine Engine Lubrication Systemmore » Simulator (TELSS) and Data Fusion Workbench (DFW). TELSS is a portable simulator code that calculates lubrication system parameters based upon one-dimensional fluid flow resistance network equations. Validation of the TF- 40B modules was performed using engineering and limited test data. The simulation model was used to analyze operational data from the LCAC fleet. The TELSS, as an integral portion of the DFW, provides the capability to experiment with combinations of variables and feature vectors that characterize normal and abnormal operation of the engine lubrication system. The model-based diagnostics approach is applicable to all gas turbine engines and mechanical transmissions with similar pressure-fed lubrication systems.« less

The Generic Resolution Advisor and Conflict Evaluator (GRACE) for Unmanned Aircraft Detect-And-Avoid Systems

NASA Technical Reports Server (NTRS)

Abramson, Michael; Refai, Mohamad; Santiago, Confesor

2017-01-01

The paper describes the Generic Resolution Advisor and Conflict Evaluator (GRACE), a novel alerting and guidance algorithm that combines flexibility, robustness, and computational efficiency. GRACE is generic since it was designed without any assumptions regarding temporal or spatial scales, aircraft performance, or its sensor and communication systems. Therefore, GRACE was adopted as a core component of the Java Architecture for Detect-And-Avoid (DAA) Extensibility and Modeling, developed by NASA as a research and modeling tool for Unmanned Aerial Systems Integration in the National Airspace System (NAS). GRACE has been used in a number of real-time and fast-time experiments supporting evolving requirements of DAA research, including parametric studies, NAS-wide simulations, human-in-the-loop experiments, and live flight tests.

Drugs, money, and power: the Canadian drug shortage.

PubMed

Kaposy, Chris

2014-03-01

This article describes the shortage of generic injectable medications in Canada that affected hospitals in 2012. It traces the events leading up to the drug shortage, the causes of the shortage, and the responses by health administrators, pharmacists, and ethicists. The article argues that generic drug shortages are an ethical problem because health care organizations and governments have an obligation to avoid exposing patients to resource scarcity. The article also discusses some options governments could pursue in order to secure the drug supply and thereby fulfill their ethical obligations.

21 CFR 884.4340 - Fetal vacuum extractor.

Code of Federal Regulations, 2011 CFR

2011-04-01

... means of a suction cup attached to the scalp and is powered by an external vacuum source. This generic type of device may include the cup, hosing, vacuum source, and vacuum control. (b) Classification...

21 CFR 884.4340 - Fetal vacuum extractor.

Code of Federal Regulations, 2010 CFR

2010-04-01

... means of a suction cup attached to the scalp and is powered by an external vacuum source. This generic type of device may include the cup, hosing, vacuum source, and vacuum control. (b) Classification...

Predictive aging results in radiation environments

NASA Astrophysics Data System (ADS)

Gillen, Kenneth T.; Clough, Roger L.

1993-06-01

We have previously derived a time-temperature-dose rate superposition methodology, which, when applicable, can be used to predict polymer degradation versus dose rate, temperature and exposure time. This methodology results in predictive capabilities at the low dose rates and long time periods appropriate, for instance, to ambient nuclear power plant environments. The methodology was successfully applied to several polymeric cable materials and then verified for two of the materials by comparisons of the model predictions with 12 year, low-dose-rate aging data on these materials from a nuclear environment. In this paper, we provide a more detailed discussion of the methodology and apply it to data obtained on a number of additional nuclear power plant cable insulation (a hypalon, a silicone rubber and two ethylene-tetrafluoroethylenes) and jacket (a hypalon) materials. We then show that the predicted, low-dose-rate results for our materials are in excellent agreement with long-term (7-9 year) low-dose-rate results recently obtained for the same material types actually aged under bnuclear power plant conditions. Based on a combination of the modelling and long-term results, we find indications of reasonably similar degradation responses among several different commercial formulations for each of the following "generic" materials: hypalon, ethylene-tetrafluoroethylene, silicone rubber and PVC. If such "generic" behavior can be further substantiated through modelling and long-term results on additional formulations, predictions of cable life for other commercial materials of the same generic types would be greatly facilitated.

Applying a Generic Intelligent Tutoring System (ITS) Authoring Tool to Specific Military Domains

DTIC Science & Technology

2006-01-01

to evaluate a student’s actions in a free play simulation, or comparison to correct and likely incorrect solutions for each scenario. There are...the student’s actions in the free play simulation. IISAT’s comparison libraries successfully evaluated a student’s battle plan with the addition of

Simulations of high-spin black-hole binaries

NASA Astrophysics Data System (ADS)

Scheel, Mark; Lovelace, Geoffrey

2014-03-01

Black holes can in principle have spins up to the Kerr limit a = 1 , and some (highly uncertain) estimates from X-ray binaries yield a > 0 . 98 . Because binaries with highly-spinning black holes may be detectable by LIGO, it is important to be able to simulate and understand these systems. We present binary black hole simulations with large spins, including a generic, precessing simulation with a spin of a > 0 . 99 on one of the black holes. We discuss some of the difficulties with simulating high-spin black holes and how to overcome them.

Does GastroPlus Support Similarity and Dissimilarity Factors of in vitro-in vivo Prediction in Biowaiver Studies? A Lower Strength Amlodipine As a Model Drug.

PubMed

Naser Zaid, Abdel; Shraim, Naser; Radwan, Asmaa; Jaradat, Nidal; Hirzallah, Samah; Issa, Ibrahim; Khraim, Aya

2018-05-23

Many generic pharmaceutical products are currently available on the market place worldwide. Recently, there is a growing concern on the quality and efficacy of generic products. However, health care professionals such as physicians and pharmacists are in difficult situations to choose among alternatives. The aim of this study is to assess the effectiveness of the in silico technique (Gastro Plus ® ) in the biowaiver study and whether similarity and dissimilarity factors ( f 2 and f 1 respectively) are effective in this regard. The concentration of amlodipine in the sample was calculated by comparing the absorbance of the sample with that of a previously prepared amlodipine standard solution using validated HPLC method. The dissolution profile for each product (brand and generics) was constructed. The similarity ( f2) and dissimilarity ( f 1 ) factors were calculated for the generic product according to equation 1 and 2. GastroPlus™ software (version 9.0, Simulations Plus Inc., Lancaster, CA, USA) was used to predict the absorption profiles of amlodipine from the generic product Amlovasc ® and the reference Norvasc ® . These results may provide a rationale for the interchangeability between the RLD and generic version based on in vitro release profiles in silico technique especially in a lower strength dose drug. © Georg Thieme Verlag KG Stuttgart · New York.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pang, Yuan-Ping, E-mail: pang@mayo.edu

Highlights: • Reducing atomic masses by 10-fold vastly improves sampling in MD simulations. • CLN025 folded in 4 of 10 × 0.5-μs MD simulations when masses were reduced by 10-fold. • CLN025 folded as early as 96.2 ns in 1 of the 4 simulations that captured folding. • CLN025 did not fold in 10 × 0.5-μs MD simulations when standard masses were used. • Low-mass MD simulation is a simple and generic sampling enhancement technique. - Abstract: CLN025 is one of the smallest fast-folding proteins. Until now it has not been reported that CLN025 can autonomously fold to its nativemore » conformation in a classical, all-atom, and isothermal–isobaric molecular dynamics (MD) simulation. This article reports the autonomous and repeated folding of CLN025 from a fully extended backbone conformation to its native conformation in explicit solvent in multiple 500-ns MD simulations at 277 K and 1 atm with the first folding event occurring as early as 66.1 ns. These simulations were accomplished by using AMBER forcefield derivatives with atomic masses reduced by 10-fold on Apple Mac Pros. By contrast, no folding event was observed when the simulations were repeated using the original AMBER forcefields of FF12SB and FF14SB. The results demonstrate that low-mass MD simulation is a simple and generic technique to enhance configurational sampling. This technique may propel autonomous folding of a wide range of miniature proteins in classical, all-atom, and isothermal–isobaric MD simulations performed on commodity computers—an important step forward in quantitative biology.« less

Performance of Comorbidity, Risk Adjustment, and Functional Status Measures in Expenditure Prediction for Patients With Diabetes

PubMed Central

Maciejewski, Matthew L.; Liu, Chuan-Fen; Fihn, Stephan D.

2009-01-01

OBJECTIVE—To compare the ability of generic comorbidity and risk adjustment measures, a diabetes-specific measure, and a self-reported functional status measure to explain variation in health care expenditures for individuals with diabetes. RESEARCH DESIGN AND METHODS—This study included a retrospective cohort of 3,092 diabetic veterans participating in a multisite trial. Two comorbidity measures, four risk adjusters, a functional status measure, a diabetes complication count, and baseline expenditures were constructed from administrative and survey data. Outpatient, inpatient, and total expenditure models were estimated using ordinary least squares regression. Adjusted R2 statistics and predictive ratios were compared across measures to assess overall explanatory power and explanatory power of low- and high-cost subgroups. RESULTS—Administrative data–based risk adjusters performed better than the comorbidity, functional status, and diabetes-specific measures in all expenditure models. The diagnostic cost groups (DCGs) measure had the greatest predictive power overall and for the low- and high-cost subgroups, while the diabetes-specific measure had the lowest predictive power. A model with DCGs and the diabetes-specific measure modestly improved predictive power. CONCLUSIONS—Existing generic measures can be useful for diabetes-specific research and policy applications, but more predictive diabetes-specific measures are needed. PMID:18945927

Generic Wing-Body Aerodynamics Data Base

NASA Technical Reports Server (NTRS)

Holst, Terry L.; Olsen, Thomas H.; Kwak, Dochan (Technical Monitor)

2001-01-01

The wing-body aerodynamics data base consists of a series of CFD (Computational Fluid Dynamics) simulations about a generic wing body configuration consisting of a ogive-circular-cylinder fuselage and a simple symmetric wing mid-mounted on the fuselage. Solutions have been obtained for Nonlinear Potential (P), Euler (E) and Navier-Stokes (N) solvers over a range of subsonic and transonic Mach numbers and angles of attack. In addition, each solution has been computed on a series of grids, coarse, medium and fine to permit an assessment of grid refinement errors.

SP-100 initial startup and restart control strategy

NASA Astrophysics Data System (ADS)

Halfen, Frank J.; Wong, Kwok K.; Switick, Dennis M.; Shukla, Jaikaran N.

Startup control strategies for SP-100 are described. Revised control and operating strategies are discussed which have been developed and tested using the SP-100 dynamic simulation model Aries-GFS (Generic Flight System).

78 FR 59662 - Annual Public Meeting of the Interagency Steering Committee on Multimedia Environmental Modeling

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-27

... applications and assessment of site specific, generic, and process-oriented multimedia environmental models as... development and simulation supports interagency interests in risk assessment, uncertainty analyses, management...

A Automated Tool for Supporting FMEAs of Digital Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yue,M.; Chu, T.-L.; Martinez-Guridi, G.

2008-09-07

Although designs of digital systems can be very different from each other, they typically use many of the same types of generic digital components. Determining the impacts of the failure modes of these generic components on a digital system can be used to support development of a reliability model of the system. A novel approach was proposed for such a purpose by decomposing the system into a level of the generic digital components and propagating failure modes to the system level, which generally is time-consuming and difficult to implement. To overcome the associated issues of implementing the proposed FMEA approach,more » an automated tool for a digital feedwater control system (DFWCS) has been developed in this study. The automated FMEA tool is in nature a simulation platform developed by using or recreating the original source code of the different module software interfaced by input and output variables that represent physical signals exchanged between modules, the system, and the controlled process. For any given failure mode, its impacts on associated signals are determined first and the variables that correspond to these signals are modified accordingly by the simulation. Criteria are also developed, as part of the simulation platform, to determine whether the system has lost its automatic control function, which is defined as a system failure in this study. The conceptual development of the automated FMEA support tool can be generalized and applied to support FMEAs for reliability assessment of complex digital systems.« less

Constraint reasoning in deep biomedical models.

PubMed

Cruz, Jorge; Barahona, Pedro

2005-05-01

Deep biomedical models are often expressed by means of differential equations. Despite their expressive power, they are difficult to reason about and make decisions, given their non-linearity and the important effects that the uncertainty on data may cause. The objective of this work is to propose a constraint reasoning framework to support safe decisions based on deep biomedical models. The methods used in our approach include the generic constraint propagation techniques for reducing the bounds of uncertainty of the numerical variables complemented with new constraint reasoning techniques that we developed to handle differential equations. The results of our approach are illustrated in biomedical models for the diagnosis of diabetes, tuning of drug design and epidemiology where it was a valuable decision-supporting tool notwithstanding the uncertainty on data. The main conclusion that follows from the results is that, in biomedical decision support, constraint reasoning may be a worthwhile alternative to traditional simulation methods, especially when safe decisions are required.

Phase Transitions and Scaling in Systems Far from Equilibrium

NASA Astrophysics Data System (ADS)

Täuber, Uwe C.

2017-03-01

Scaling ideas and renormalization group approaches proved crucial for a deep understanding and classification of critical phenomena in thermal equilibrium. Over the past decades, these powerful conceptual and mathematical tools were extended to continuous phase transitions separating distinct nonequilibrium stationary states in driven classical and quantum systems. In concordance with detailed numerical simulations and laboratory experiments, several prominent dynamical universality classes have emerged that govern large-scale, long-time scaling properties both near and far from thermal equilibrium. These pertain to genuine specific critical points as well as entire parameter space regions for steady states that display generic scale invariance. The exploration of nonstationary relaxation properties and associated physical aging scaling constitutes a complementary potent means to characterize cooperative dynamics in complex out-of-equilibrium systems. This review describes dynamic scaling features through paradigmatic examples that include near-equilibrium critical dynamics, driven lattice gases and growing interfaces, correlation-dominated reaction-diffusion systems, and basic epidemic models.

Orientational order of motile defects in active nematics

DOE PAGES

DeCamp, Stephen J.; Redner, Gabriel S.; Baskaran, Aparna; ...

2015-08-17

The study of equilibrium liquid crystals has led to fundamental insights into the nature of ordered materials, as well as many practical applications such as display technologies. Active nematics are a fundamentally different class of liquid crystals, which are driven away from equilibrium by the autonomous motion of their constituent rodlike particles. This internally-generated activity powers the continuous creation and annihilation of topological defects, leading to complex streaming flows whose chaotic dynamics appear to destroy long-range order. Here, we study these dynamics in experimental and computational realizations of active nematics. By tracking thousands of defects over centimeter distances in microtubule-basedmore » active nematics, we identify a non-equilibrium phase characterized by system-spanning orientational order of defects. This emergent order persists over hours despite defect lifetimes of only seconds. Lastly, similar dynamical structures are observed in coarse-grained simulations, suggesting that defect-ordered phases are a generic feature of active nematics.« less

Navier-Stokes calculations of scramjet-nozzle-afterbody flowfields

NASA Technical Reports Server (NTRS)

Baysal, Oktay

1991-01-01

A comprehensive computational fluid dynamics effort was conducted from 1987 to 1990 to properly design a nozzle and lower aft end of a generic hypersonic vehicle powered by a scramjet engine. The interference of the exhaust on the control surfaces of the vehicle can have adverse effects on its stability. Two-dimensional Navier-Stokes computations were performed, where the exhaust gas was assumed to be air behaving as a perfect gas. Then the exhaust was simulated by a mixture of Freon-12 and argon, which required solving the Navier-Stokes equations for four species: (nitrogen, oxygen, Freon-12, and argon). This allowed gamma to be a field variable during the mixing of the multispecies gases. Two different mixing models were used and comparisons between them as well as the perfect gas air calculations were made to assess their relative merits. Finally, the three dimensional Navier-Stokes computations were made for the full-span scramjet nozzle afterbody module.

Navier-Stokes calculations of scramjet-nozzle-afterbody flowfields

NASA Astrophysics Data System (ADS)

Baysal, Oktay

1991-07-01

A comprehensive computational fluid dynamics effort was conducted from 1987 to 1990 to properly design a nozzle and lower aft end of a generic hypersonic vehicle powered by a scramjet engine. The interference of the exhaust on the control surfaces of the vehicle can have adverse effects on its stability. Two-dimensional Navier-Stokes computations were performed, where the exhaust gas was assumed to be air behaving as a perfect gas. Then the exhaust was simulated by a mixture of Freon-12 and argon, which required solving the Navier-Stokes equations for four species: (nitrogen, oxygen, Freon-12, and argon). This allowed gamma to be a field variable during the mixing of the multispecies gases. Two different mixing models were used and comparisons between them as well as the perfect gas air calculations were made to assess their relative merits. Finally, the three dimensional Navier-Stokes computations were made for the full-span scramjet nozzle afterbody module.

A generic analytical foot rollover model for predicting translational ankle kinematics in gait simulation studies.

PubMed

Ren, Lei; Howard, David; Ren, Luquan; Nester, Chris; Tian, Limei

2010-01-19

The objective of this paper is to develop an analytical framework to representing the ankle-foot kinematics by modelling the foot as a rollover rocker, which cannot only be used as a generic tool for general gait simulation but also allows for case-specific modelling if required. Previously, the rollover models used in gait simulation have often been based on specific functions that have usually been of a simple form. In contrast, the analytical model described here is in a general form that the effective foot rollover shape can be represented by any polar function rho=rho(phi). Furthermore, a normalized generic foot rollover model has been established based on a normative foot rollover shape dataset of 12 normal healthy subjects. To evaluate model accuracy, the predicted ankle motions and the centre of pressure (CoP) were compared with measurement data for both subject-specific and general cases. The results demonstrated that the ankle joint motions in both vertical and horizontal directions (relative RMSE approximately 10%) and CoP (relative RMSE approximately 15% for most of the subjects) are accurately predicted over most of the stance phase (from 10% to 90% of stance). However, we found that the foot cannot be very accurately represented by a rollover model just after heel strike (HS) and just before toe off (TO), probably due to shear deformation of foot plantar tissues (ankle motion can occur without any foot rotation). The proposed foot rollover model can be used in both inverse and forward dynamics gait simulation studies and may also find applications in rehabilitation engineering. Copyright 2009 Elsevier Ltd. All rights reserved.

Generic atorvastatin, the Belgian statin market and the cost-effectiveness of statin therapy.

PubMed

Simoens, Steven; Sinnaeve, Peter R

2013-02-01

This study examines how the market entry of generic atorvastatin influences the Belgian statin market and the cost-effectiveness of statin therapy. Using IMS Health data, the Belgian 2000-2011 statin market was analyzed in terms of total expenditure, annual price of statin treatment, and patient numbers. A simulation analysis projected statin market shares from 2012 to 2015 following market entry of generic atorvastatin. This analysis was based on three scenarios regarding the number of patients taking specific statins. Savings associated with an atorvastatin price reduction of 50-70 % were calculated. A literature review of economic evaluations assessed the cost-effectiveness of generic atorvastatin. Statin expenditure increased from €113 million in 2000 to €285 million in 2011 due to higher expenditure on atorvastatin and rosuvastatin. Although the number of patients treated with simvastatin increased by nearly 800 %, the resulting increase in expenditure was partially offset by price reductions. Atorvastatin is projected to become the dominant product in the Belgian statin market (market share of 47-66 % by 2015). Annual savings would attain €108.6-€153.7 million for a 50 % reduction in the atorvastatin price and €152.0-€215.2 million for a 70 % price reduction. The literature suggests that generic atorvastatin is cost-effective as compared to simvastatin. The limited evidence about the cost-effectiveness of rosuvastatin as compared with generic atorvastatin is inconclusive. Generic atorvastatin is cost-effective as compared to simvastatin, is projected to become the dominant product in the Belgian statin market and is expected to generate substantial savings to health care payers.

Utilization and costs of HIV antiretroviral drugs in Europe during the last ten years: Impact of generic antiretroviral drugs on cost reduction.

PubMed

Rwagitinywa, Joseph; Sommet, Agnès; Palmaro, Aurore; Montastruc, Jean-Louis; Lapeyre-Mestre, Maryse

2018-03-01

Simulation studies showed that generic antiretroviral (ARV) drug utilization could lead to significant cost reduction of HIV treatment in developed world. This study aimed to quantify ARV utilization and costs in European countries between 2006 and 2015. We also assessed the impact of generic ARV drug utilization on cost reduction in real-life. ARV drug utilization in 14 European countries (France, Italy, Germany, Denmark, Netherlands, Norway, Sweden, Finland, Iceland, Croatia, Czech Republic, Estonia, Latvia, and Lithuania) were analysed using defined daily dose (DDD)/1000 inhabitants/year. ARV drug cost was estimated in million euro/year and euro/1000 inhabitants/year. The impact of generics on cost reduction was assessed in three countries: France, Denmark, and Czech Republic, using four parameters: expected savings, observed savings, brand price-reduction savings and overall savings. Between 2006 and 2015, median ARV drug utilization increased from 234 DDDs per 1000 inhabitants per year (IQR 124-388) to 385 (229-670). The median cost increased from €3751/1000 inhabitants/year (1109-4681) to €9158 (3269-10,646). Between 2013 and 2015, overall savings of €0.9, €1.6, and €33.7 million were respectively observed in Denmark, Czech Republic, and France. Overall savings observed in real-life from generic ARV drugs in Denmark were related to high rate of low-price generic utilization, contrarily to France and Czech Republic where these were more related to brand price-reduction than generic utilization itself. Copyright © 2018 Elsevier B.V. All rights reserved.

Designing Successful Next-Generation Instruments to Detect the Epoch of Reionization

NASA Astrophysics Data System (ADS)

Thyagarajan, Nithyanandan; Hydrogen Epoch of Reionization Array (HERA) team, Murchison Widefield Array (MWA) team

2018-01-01

The Epoch of Reionization (EoR) signifies a period of intense evolution of the Inter-Galactic Medium (IGM) in the early Universe caused by the first generations of stars and galaxies, wherein they turned the neutral IGM to be completely ionized by redshift ≥ 6. This important epoch is poorly explored to date. Measurement of redshifted 21 cm line from neutral Hydrogen during the EoR is promising to provide the most direct constraints of this epoch. Ongoing experiments to detect redshifted 21 cm power spectrum during reionization, including the Murchison Widefield Array (MWA), Precision Array for Probing the Epoch of Reionization (PAPER), and the Low Frequency Array (LOFAR), appear to be severely affected by bright foregrounds and unaccounted instrumental systematics. For example, the spectral structure introduced by wide-field effects, aperture shapes and angular power patterns of the antennas, electrical and geometrical reflections in the antennas and electrical paths, and antenna position errors can be major limiting factors. These mimic the 21 cm signal and severely degrade the instrument performance. It is imperative for the next-generation of experiments to eliminate these systematics at their source via robust instrument design. I will discuss a generic framework to set cosmologically motivated antenna performance specifications and design strategies using the Precision Radio Interferometry Simulator (PRISim) -- a high-precision tool that I have developed for simulations of foregrounds and the instrument transfer function intended primarily for 21 cm EoR studies, but also broadly applicable to interferometer-based intensity mapping experiments. The Hydrogen Epoch of Reionization Array (HERA), designed in-part based on this framework, is expected to detect the 21 cm signal with high significance. I will present this framework and the simulations, and their potential for designing upcoming radio instruments such as HERA and the Square Kilometre Array (SKA).

Dosimetric characteristics of electron beams produced by a mobile accelerator for IORT.

PubMed

Pimpinella, M; Mihailescu, D; Guerra, A S; Laitano, R F

2007-10-21

Energy and angular distributions of electron beams with different energies were simulated by Monte Carlo calculations. These beams were generated by the NOVAC7 system (Hitesys, Italy), a mobile electron accelerator specifically dedicated to intra-operative radiation therapy (IORT). The electron beam simulations were verified by comparing the measured dose distributions with the corresponding calculated distributions. As expected, a considerable difference was observed in the energy and angular distributions between the IORT beams studied in the present work and the electron beams produced by conventional accelerators for non-IORT applications. It was also found that significant differences exist between the IORT beams used in this work and other IORT beams with different collimation systems. For example, the contribution from the scattered electrons to the total dose was found to be up to 15% higher in the NOVAC7 beams. The water-to-air stopping power ratios of the IORT beams used in this work were calculated on the basis of the beam energy distributions obtained by the Monte Carlo simulations. These calculated stopping power ratios, s(w,air), were compared with the corresponding s(w,air) values recommended by the TRS-381 and TRS-398 IAEA dosimetry protocols in order to estimate the deviations between a dosimetry based on generic parameters and a dosimetry based on parameters specifically obtained for the actual IORT beams. The deviations in the s(w,air) values were found to be as large as up to about 1%. Therefore, we recommend that a preliminary analysis should always be made when dealing with IORT beams in order to assess to what extent the possible differences in the s(w,air) values have to be accounted for or may be neglected on the basis of the specific accuracy needed in clinical dosimetry.

A High-Fidelity Simulation of a Generic Commercial Aircraft Engine and Controller

NASA Technical Reports Server (NTRS)

May, Ryan D.; Csank, Jeffrey; Lavelle, Thomas M.; Litt, Jonathan S.; Guo, Ten-Huei

2010-01-01

A new high-fidelity simulation of a generic 40,000 lb thrust class commercial turbofan engine with a representative controller, known as CMAPSS40k, has been developed. Based on dynamic flight test data of a highly instrumented engine and previous engine simulations developed at NASA Glenn Research Center, this non-proprietary simulation was created especially for use in the development of new engine control strategies. C-MAPSS40k is a highly detailed, component-level engine model written in MATLAB/Simulink (The MathWorks, Inc.). Because the model is built in Simulink, users have the ability to use any of the MATLAB tools for analysis and control system design. The engine components are modeled in C-code, which is then compiled to allow faster-than-real-time execution. The engine controller is based on common industry architecture and techniques to produce realistic closed-loop transient responses while ensuring that no safety or operability limits are violated. A significant feature not found in other non-proprietary models is the inclusion of transient stall margin debits. These debits provide an accurate accounting of the compressor surge margin, which is critical in the design of an engine controller. This paper discusses the development, characteristics, and capabilities of the C-MAPSS40k simulation

The analysis of a generic air-to-air missile simulation model

NASA Technical Reports Server (NTRS)

Kaplan, Joseph A.; Chappell, Alan R.; Mcmanus, John W.

1994-01-01

A generic missile model was developed to evaluate the benefits of using a dynamic missile fly-out simulation system versus a static missile launch envelope system for air-to-air combat simulation. This paper examines the performance of a launch envelope model and a missile fly-out model. The launch envelope model bases its probability of killing the target aircraft on the target aircraft's position at the launch time of the weapon. The benefits gained from a launch envelope model are the simplicity of implementation and the minimal computational overhead required. A missile fly-out model takes into account the physical characteristics of the missile as it simulates the guidance, propulsion, and movement of the missile. The missile's probability of kill is based on the missile miss distance (or the minimum distance between the missile and the target aircraft). The problems associated with this method of modeling are a larger computational overhead, the additional complexity required to determine the missile miss distance, and the additional complexity of determining the reason(s) the missile missed the target. This paper evaluates the two methods and compares the results of running each method on a comprehensive set of test conditions.

Integrated corridor management analysis, modeling and simulation (AMS) methodology.

DOT National Transportation Integrated Search

2008-03-01

This AMS Methodologies Document provides a discussion of potential ICM analytical approaches for the assessment of generic corridor operations. The AMS framework described in this report identifies strategies and procedures for tailoring AMS general ...

76 FR 69769 - Annual Public Meeting of the Interagency Steering Committee on Multimedia Environmental Modeling

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... assessments of site specific, generic, and process-oriented multimedia environmental models as they pertain to human and environmental health risk assessment. Multimedia model development and simulation supports...

Performance Assessments of Generic Nuclear Waste Repositories in Shale

NASA Astrophysics Data System (ADS)

Stein, E. R.; Sevougian, S. D.; Mariner, P. E.; Hammond, G. E.; Frederick, J.

2017-12-01

Simulations of deep geologic disposal of nuclear waste in a generic shale formation showcase Geologic Disposal Safety Assessment (GDSA) Framework, a toolkit for repository performance assessment (PA) whose capabilities include domain discretization (Cubit), multiphysics simulations (PFLOTRAN), uncertainty and sensitivity analysis (Dakota), and visualization (Paraview). GDSA Framework is used to conduct PAs of two generic repositories in shale. The first considers the disposal of 22,000 metric tons heavy metal of commercial spent nuclear fuel. The second considers disposal of defense-related spent nuclear fuel and high level waste. Each PA accounts for the thermal load and radionuclide inventory of applicable waste types, components of the engineered barrier system, and components of the natural barrier system including the host rock shale and underlying and overlying stratigraphic units. Model domains are half-symmetry, gridded with Cubit, and contain between 7 and 22 million grid cells. Grid refinement captures the detail of individual waste packages, emplacement drifts, access drifts, and shafts. Simulations are run in a high performance computing environment on as many as 2048 processes. Equations describing coupled heat and fluid flow and reactive transport are solved with PFLOTRAN, an open-source, massively parallel multiphase flow and reactive transport code. Additional simulated processes include waste package degradation, waste form dissolution, radioactive decay and ingrowth, sorption, solubility, advection, dispersion, and diffusion. Simulations are run to 106 y, and radionuclide concentrations are observed within aquifers at a point approximately 5 km downgradient of the repository. Dakota is used to sample likely ranges of input parameters including waste form and waste package degradation rates and properties of engineered and natural materials to quantify uncertainty in predicted concentrations and sensitivity to input parameters. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia, LLC., a wholly owned subsidiary of Honeywell International, Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA-0003525. SAND2017- 8305 A

Visuospatial and psychomotor aptitude predicts endovascular performance of inexperienced individuals on a virtual reality simulator.

PubMed

Van Herzeele, Isabelle; O'Donoghue, Kevin G L; Aggarwal, Rajesh; Vermassen, Frank; Darzi, Ara; Cheshire, Nicholas J W

2010-04-01

This study evaluated virtual reality (VR) simulation for endovascular training of medical students to determine whether innate perceptual, visuospatial, and psychomotor aptitude (VSA) can predict initial and plateau phase of technical endovascular skills acquisition. Twenty medical students received didactic and endovascular training on a commercially available VR simulator. Each student treated a series of 10 identical noncomplex renal artery stenoses endovascularly. The simulator recorded performance data instantly and objectively. An experienced interventionalist rated the performance at the initial and final sessions using generic (out of 40) and procedure-specific (out of 30) rating scales. VSA were tested with fine motor dexterity (FMD, Perdue Pegboard), psychomotor ability (minimally invasive virtual reality surgical trainer [MIST-VR]), image recall (Rey-Osterrieth), and organizational aptitude (map-planning). VSA performance scores were correlated with the assessment parameters of endovascular skills at commencement and completion of training. Medical students exhibited statistically significant learning curves from the initial to the plateau performance for contrast usage (medians, 28 vs 17 mL, P < .001), total procedure time (2120 vs 867 seconds, P < .001), and fluoroscopy time (993 vs. 507 seconds, P < .001). Scores on generic and procedure-specific rating scales improved significantly (10 vs 25, P < .001; 8 vs 17 P < .001). Significant correlations were noted for FMD with initial and plateau sessions for fluoroscopy time (r(s) = -0.564, P = .010; r(s) = -.449, P = .047). FMD correlated with procedure-specific scores at the initial session (r(s) = .607, P = .006). Image recall correlated with generic skills at the end of training (r(s) = .587, P = .006). Simulator-based training in endovascular skills improved performance in medical students. There were significant correlations between initial endovascular skill and fine motor dexterity as well as with image recall at end of the training period. In addition to current recruitment strategies, VSA may be a useful tool for predictive validity studies.

Investigating the dissolution profiles of amoxicillin, metronidazole, and zidovudine formulations used in Trinidad and Tobago, West Indies.

PubMed

Stuart, Arlene Villarroel; Zuo, Jieyu; Löbenberg, Raimar

2014-10-01

Trinidad and Tobago is a twin-island Republic in the Caribbean and like many developing countries, it has included generic drugs on the national drug formulary to decrease the financial burden of pharmaceutical medications. However, to ensure that medications received by patients are beneficial, generic drugs need to be interchangeable with the innovator which has demonstrated safety, efficacy, and quality. The objective of the study was to compare the dissolution profiles and weight variations for different formulations of amoxicillin, metronidazole, and zidovudine that are on the national drug formulary and marketed in Trinidad and Tobago. All the products investigated are categorized as class 1 drugs according to the Biopharmaceutics Classification System (BCS) and the dissolution profiles were assessed according to the World Health Organization (WHO) criteria for interchangeability between products. The similarity factor, f 2, was used to determine sameness between the products. No generic formulation was found to be similar to Amoxil® 500-mg capsules. The two generic products for metronidazole 200-mg tablets demonstrated more than 85% drug release within 15 min in all three of the buffers; however, their 400-mg counterparts did not fulfill this requirement. The zidovudine 300-mg tablet complied with the requirements in buffer pH 4.5 and simulated gastric fluid (SGF) but not for simulated intestinal fluid (SIF). Some Class 1 pharmaceutical formulations may possess the same active ingredient and amount of drug but may show significant differences to in vitro equivalence requirements. Nevertheless, the dissolution process is suitable to detect these variations.

Energy droughts in a 100% renewable electricity mix

NASA Astrophysics Data System (ADS)

Raynaud, Damien; Hingray, Benoît; François, Baptiste; Creutin, Jean-Dominique

2017-04-01

During the 21st conference of parties, 175 countries agreed on limiting the temperature increase due to global warming to 2°C above preindustrial levels. Such an ambitious goal necessitates a deep transformation of our society in order to reduce greenhouse gas (GHG) emissions. Europe has started its energy transition years ago by, for instance, increasing the share of renewables in the European electricity generation and should continue in this direction. Variable renewable energies (VRE) and especially those driven by weather conditions (namely wind, solar and hydro power from river flow), are expected to play a key role in achieving the GHG reduction target. However, these renewables are often criticized for their intermittency and for the resulting difficult integration in the power supply system, especially for large shares of VRE in the energy mix. Assessing the feasibility of electricity generation using large contributions of VRE requires a deep understanding and characterization of the VRE spatiotemporal variations. In the last decade, many studies have focused on the short-term intermittency of VRE generation, but the persistency and the characteristics of periods of low/high electricity generation have been rarely studied. Yet, these particular situations require some demanding adaptations of the power supply system in term of back-up sources or production curtailment respectively. This study focuses on what we call "energy droughts" which, by analogy with hydrological or meteorological droughts, are defined as periods of very low energy production. We consider in turn "energy droughts" associated to wind, solar and hydro power (run-of-the-river). Their characteristics are estimated for 12 European regions being subjected to different climatic regimes. For each region and energy source, "droughts" are evaluated from a 30-yr time series of power generation (1983-2012). These series are simulated by using a suite of weather-to-energy conversion models with generic power systems (generic wind, solar and hydro power plant) and observations or pseudo-observations of meteorological drivers. The daily river discharge series required for hydro power are generated using a hydrological model. Our results demonstrate the diversity of characteristics of energy droughts not only from one energy source to the other, but also depending on the region and on the season considered. Wind power generally presents short but frequent energy droughts whereas hydro-power-related droughts are rare but generally long lasting. Solar power is mainly driven by the length of daytime resulting in long winter "solar drought" in Northern regions. We finally assess the energy droughts characteristics of an energy mix for which the three VRE sources are combined. The proportions of wind, solar and hydro power considered in the regional mixes are based on the work of François et al. (2016b). Mixing VRE sources efficiently reduces both duration and frequency of energy droughts leading to a more reliable power supply. References : François, B., Hingray, B., Raynaud, D., Borga, M., Creutin, J.D., 2016b. Increasing climate-related-energy penetration by integrating run-of-the river hydropower to wind/solar mix. Renew. Energy 87, 686-696. doi:10.1016/j.renene.2015.10.064

Human Factors and Technical Considerations for a Computerized Operator Support System Prototype

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ulrich, Thomas Anthony; Lew, Roger Thomas; Medema, Heather Dawne

2015-09-01

A prototype computerized operator support system (COSS) has been developed in order to demonstrate the concept and provide a test bed for further research. The prototype is based on four underlying elements consisting of a digital alarm system, computer-based procedures, PI&D system representations, and a recommender module for mitigation actions. At this point, the prototype simulates an interface to a sensor validation module and a fault diagnosis module. These two modules will be fully integrated in the next version of the prototype. The initial version of the prototype is now operational at the Idaho National Laboratory using the U.S. Departmentmore » of Energy’s Light Water Reactor Sustainability (LWRS) Human Systems Simulation Laboratory (HSSL). The HSSL is a full-scope, full-scale glass top simulator capable of simulating existing and future nuclear power plant main control rooms. The COSS is interfaced to the Generic Pressurized Water Reactor (gPWR) simulator with industry-typical control board layouts. The glass top panels display realistic images of the control boards that can be operated by touch gestures. A section of the simulated control board was dedicated to the COSS human-system interface (HSI), which resulted in a seamless integration of the COSS into the normal control room environment. A COSS demonstration scenario has been developed for the prototype involving the Chemical & Volume Control System (CVCS) of the PWR simulator. It involves a primary coolant leak outside of containment that would require tripping the reactor if not mitigated in a very short timeframe. The COSS prototype presents a series of operator screens that provide the needed information and soft controls to successfully mitigate the event.« less

Virial Coefficients from Unified Statistical Thermodynamics of Quantum Gases Trapped under Generic Power Law Potential in d Dimension and Equivalence of Quantum Gases

NASA Astrophysics Data System (ADS)

Bahauddin, Shah Mohammad; Mehedi Faruk, Mir

2016-09-01

From the unified statistical thermodynamics of quantum gases, the virial coefficients of ideal Bose and Fermi gases, trapped under generic power law potential are derived systematically. From the general result of virial coefficients, one can produce the known results in d = 3 and d = 2. But more importantly we found that, the virial coefficients of Bose and Fermi gases become identical (except the second virial coefficient, where the sign is different) when the gases are trapped under harmonic potential in d = 1. This result suggests the equivalence between Bose and Fermi gases established in d = 1 (J. Stat. Phys. DOI 10.1007/s10955-015-1344-4). Also, it is found that the virial coefficients of two-dimensional free Bose (Fermi) gas are equal to the virial coefficients of one-dimensional harmonically trapped Bose (Fermi) gas.

GridPV Toolbox

DOE Office of Scientific and Technical Information (OSTI.GOV)

Broderick, Robert; Quiroz, Jimmy; Grijalva, Santiago

2014-07-15

Matlab Toolbox for simulating the impact of solar energy on the distribution grid. The majority of the functions are useful for interfacing OpenDSS and MATLAB, and they are of generic use for commanding OpenDSS from MATLAB and retrieving GridPV Toolbox information from simulations. A set of functions is also included for modeling PV plant output and setting up the PV plant in the OpenDSS simulation. The toolbox contains functions for modeling the OpenDSS distribution feeder on satellite images with GPS coordinates. Finally, example simulations functions are included to show potential uses of the toolbox functions.

Testability, Test Automation and Test Driven Development for the Trick Simulation Toolkit

NASA Technical Reports Server (NTRS)

Penn, John

2014-01-01

This paper describes the adoption of a Test Driven Development approach and a Continuous Integration System in the development of the Trick Simulation Toolkit, a generic simulation development environment for creating high fidelity training and engineering simulations at the NASA Johnson Space Center and many other NASA facilities. It describes the approach, and the significant benefits seen, such as fast, thorough and clear test feedback every time code is checked into the code repository. It also describes an approach that encourages development of code that is testable and adaptable.

Self-avoiding walks on scale-free networks

NASA Astrophysics Data System (ADS)

Herrero, Carlos P.

2005-01-01

Several kinds of walks on complex networks are currently used to analyze search and navigation in different systems. Many analytical and computational results are known for random walks on such networks. Self-avoiding walks (SAW’s) are expected to be more suitable than unrestricted random walks to explore various kinds of real-life networks. Here we study long-range properties of random SAW’s on scale-free networks, characterized by a degree distribution P (k) ˜ k-γ . In the limit of large networks (system size N→∞ ), the average number sn of SAW’s starting from a generic site increases as μn , with μ= < k2 > / -1 . For finite N , sn is reduced due to the presence of loops in the network, which causes the emergence of attrition of the paths. For kinetic growth walks, the average maximum length increases as a power of the system size: ˜ Nα , with an exponent α increasing as the parameter γ is raised. We discuss the dependence of α on the minimum allowed degree in the network. A similar power-law dependence is found for the mean self-intersection length of nonreversal random walks. Simulation results support our approximate analytical calculations.

EM Modeling of Far-Field Radiation Patterns for Antennas on the GMA-TT UAV

NASA Technical Reports Server (NTRS)

Mackenzie, Anne I.

2015-01-01

To optimize communication with the Generic Modular Aircraft T-Tail (GMA-TT) unmanned aerial vehicle (UAV), electromagnetic (EM) simulations have been performed to predict the performance of two antenna types on the aircraft. Simulated far-field radiation patterns tell the amount of power radiated by the antennas and the aircraft together, taking into account blockage by the aircraft as well as radiation by conducting and dielectric portions of the aircraft. With a knowledge of the polarization and distance of the two communicating antennas, e.g. one on the UAV and one on the ground, and the transmitted signal strength, a calculation may be performed to find the strength of the signal travelling from one antenna to the other and to check that the transmitted signal meets the receiver system requirements for the designated range. In order to do this, the antenna frequency and polarization must be known for each antenna, in addition to its design and location. The permittivity, permeability, and geometry of the UAV components must also be known. The full-wave method of moments solution produces the appropriate dBi radiation pattern in which the received signal strength is calculated relative to that of an isotropic radiator.

Integrated Control Modeling for Propulsion Systems Using NPSS

NASA Technical Reports Server (NTRS)

Parker, Khary I.; Felder, James L.; Lavelle, Thomas M.; Withrow, Colleen A.; Yu, Albert Y.; Lehmann, William V. A.

2004-01-01

The Numerical Propulsion System Simulation (NPSS), an advanced engineering simulation environment used to design and analyze aircraft engines, has been enhanced by integrating control development tools into it. One of these tools is a generic controller interface that allows NPSS to communicate with control development software environments such as MATLAB and EASY5. The other tool is a linear model generator (LMG) that gives NPSS the ability to generate linear, time-invariant state-space models. Integrating these tools into NPSS enables it to be used for control system development. This paper will discuss the development and integration of these tools into NPSS. In addition, it will show a comparison of transient model results of a generic, dual-spool, military-type engine model that has been implemented in NPSS and Simulink. It will also show the linear model generator s ability to approximate the dynamics of a nonlinear NPSS engine model.

Polymer collapse in miscible good solvents is a generic phenomenon driven by preferential adsorption

PubMed Central

Mukherji, Debashish; Marques, Carlos M.; Kremer, Kurt

2014-01-01

Water and alcohol, such as methanol or ethanol, are miscible and, individually, good solvents for poly(N-isopropylacrylamide) (PNIPAm), but this polymer precipitates in water–alcohol mixtures. The intriguing behaviour of solvent mixtures that cannot dissolve a given polymer or a given protein, while the same macromolecule dissolves well in each of the cosolvents, is called cononsolvency. It is a widespread phenomenon, relevant for many formulation steps in the physicochemical and pharmaceutical industry, that is usually explained by invoking specific chemical details of the mixtures: as such, it has so far eluded any generic explanation. Here, by using a combination of simulations and theory, we present a simple and universal treatment that requires only the preferential interaction of one of the cosolvents with the polymer. The results show striking quantitative agreement with experiments and chemically specific simulations, opening a new perspective towards an operational understanding of macromolecular solubility. PMID:25216245

Control Design for a Generic Commercial Aircraft Engine

NASA Technical Reports Server (NTRS)

Csank, Jeffrey; May, Ryan D.

2010-01-01

This paper describes the control algorithms and control design process for a generic commercial aircraft engine simulation of a 40,000 lb thrust class, two spool, high bypass ratio turbofan engine. The aircraft engine is a complex nonlinear system designed to operate over an extreme range of environmental conditions, at temperatures from approximately -60 to 120+ F, and at altitudes from below sea level to 40,000 ft, posing multiple control design constraints. The objective of this paper is to provide the reader an overview of the control design process, design considerations, and justifications as to why the particular architecture and limits have been chosen. The controller architecture contains a gain-scheduled Proportional Integral controller along with logic to protect the aircraft engine from exceeding any limits. Simulation results illustrate that the closed loop system meets the Federal Aviation Administration s thrust response requirements

Generic simulation of multi-element ladar scanner kinematics in USU LadarSIM

NASA Astrophysics Data System (ADS)

Omer, David; Call, Benjamin; Pack, Robert; Fullmer, Rees

2006-05-01

This paper presents a generic simulation model for a ladar scanner with up to three scan elements, each having a steering, stabilization and/or pattern-scanning role. Of interest is the development of algorithms that automatically generate commands to the scan elements given beam-steering objectives out of the ladar aperture, and the base motion of the sensor platform. First, a straight-forward single-element body-fixed beam-steering methodology is presented. Then a unique multi-element redirective and reflective space-fixed beam-steering methodology is explained. It is shown that standard direction cosine matrix decomposition methods fail when using two orthogonal, space-fixed rotations, thus demanding the development of a new algorithm for beam steering. Finally, a related steering control methodology is presented that uses two separate optical elements mathematically combined to determine the necessary scan element commands. Limits, restrictions, and results on this methodology are presented.

Efficient patient modeling for visuo-haptic VR simulation using a generic patient atlas.

PubMed

Mastmeyer, Andre; Fortmeier, Dirk; Handels, Heinz

2016-08-01

This work presents a new time-saving virtual patient modeling system by way of example for an existing visuo-haptic training and planning virtual reality (VR) system for percutaneous transhepatic cholangio-drainage (PTCD). Our modeling process is based on a generic patient atlas to start with. It is defined by organ-specific optimized models, method modules and parameters, i.e. mainly individual segmentation masks, transfer functions to fill the gaps between the masks and intensity image data. In this contribution, we show how generic patient atlases can be generalized to new patient data. The methodology consists of patient-specific, locally-adaptive transfer functions and dedicated modeling methods such as multi-atlas segmentation, vessel filtering and spline-modeling. Our full image volume segmentation algorithm yields median DICE coefficients of 0.98, 0.93, 0.82, 0.74, 0.51 and 0.48 regarding soft-tissue, liver, bone, skin, blood and bile vessels for ten test patients and three selected reference patients. Compared to standard slice-wise manual contouring time saving is remarkable. Our segmentation process shows out efficiency and robustness for upper abdominal puncture simulation systems. This marks a significant step toward establishing patient-specific training and hands-on planning systems in a clinical environment. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Spectral unmixing of urban land cover using a generic library approach

NASA Astrophysics Data System (ADS)

Degerickx, Jeroen; Lordache, Marian-Daniel; Okujeni, Akpona; Hermy, Martin; van der Linden, Sebastian; Somers, Ben

2016-10-01

Remote sensing based land cover classification in urban areas generally requires the use of subpixel classification algorithms to take into account the high spatial heterogeneity. These spectral unmixing techniques often rely on spectral libraries, i.e. collections of pure material spectra (endmembers, EM), which ideally cover the large EM variability typically present in urban scenes. Despite the advent of several (semi-) automated EM detection algorithms, the collection of such image-specific libraries remains a tedious and time-consuming task. As an alternative, we suggest the use of a generic urban EM library, containing material spectra under varying conditions, acquired from different locations and sensors. This approach requires an efficient EM selection technique, capable of only selecting those spectra relevant for a specific image. In this paper, we evaluate and compare the potential of different existing library pruning algorithms (Iterative Endmember Selection and MUSIC) using simulated hyperspectral (APEX) data of the Brussels metropolitan area. In addition, we develop a new hybrid EM selection method which is shown to be highly efficient in dealing with both imagespecific and generic libraries, subsequently yielding more robust land cover classification results compared to existing methods. Future research will include further optimization of the proposed algorithm and additional tests on both simulated and real hyperspectral data.

Driver compliance to take-over requests with different auditory outputs in conditional automation.

PubMed

Forster, Yannick; Naujoks, Frederik; Neukum, Alexandra; Huestegge, Lynn

2017-12-01

Conditionally automated driving (CAD) systems are expected to improve traffic safety. Whenever the CAD system exceeds its limit of operation, designers of the system need to ensure a safe and timely enough transition from automated to manual mode. An existing visual Human-Machine Interface (HMI) was supplemented by different auditory outputs. The present work compares the effects of different auditory outputs in form of (1) a generic warning tone and (2) additional semantic speech output on driver behavior for the announcement of an upcoming take-over request (TOR). We expect the information carried by means of speech output to lead to faster reactions and better subjective evaluations by the drivers compared to generic auditory output. To test this assumption, N=17 drivers completed two simulator drives, once with a generic warning tone ('Generic') and once with additional speech output ('Speech+generic'), while they were working on a non-driving related task (NDRT; i.e., reading a magazine). Each drive incorporated one transition from automated to manual mode when yellow secondary lanes emerged. Different reaction time measures, relevant for the take-over process, were assessed. Furthermore, drivers evaluated the complete HMI regarding usefulness, ease of use and perceived visual workload just after experiencing the take-over. They gave comparative ratings on usability and acceptance at the end of the experiment. Results revealed that reaction times, reflecting information processing time (i.e., hands on the steering wheel, termination of NDRT), were shorter for 'Speech+generic' compared to 'Generic' while reaction time, reflecting allocation of attention (i.e., first glance ahead), did not show this difference. Subjective ratings were in favor of the system with additional speech output. Copyright © 2017 Elsevier Ltd. All rights reserved.

DigR: a generic model and its open source simulation software to mimic three-dimensional root-system architecture diversity.

PubMed

Barczi, Jean-François; Rey, Hervé; Griffon, Sébastien; Jourdan, Christophe

2018-04-18

Many studies exist in the literature dealing with mathematical representations of root systems, categorized, for example, as pure structure description, partial derivative equations or functional-structural plant models. However, in these studies, root architecture modelling has seldom been carried out at the organ level with the inclusion of environmental influences that can be integrated into a whole plant characterization. We have conducted a multidisciplinary study on root systems including field observations, architectural analysis, and formal and mathematical modelling. This integrative and coherent approach leads to a generic model (DigR) and its software simulator. Architecture analysis applied to root systems helps at root type classification and architectural unit design for each species. Roots belonging to a particular type share dynamic and morphological characteristics which consist of topological and geometric features. The DigR simulator is integrated into the Xplo environment, with a user interface to input parameter values and make output ready for dynamic 3-D visualization, statistical analysis and saving to standard formats. DigR is simulated in a quasi-parallel computing algorithm and may be used either as a standalone tool or integrated into other simulation platforms. The software is open-source and free to download at http://amapstudio.cirad.fr/soft/xplo/download. DigR is based on three key points: (1) a root-system architectural analysis, (2) root type classification and modelling and (3) a restricted set of 23 root type parameters with flexible values indexed in terms of root position. Genericity and botanical accuracy of the model is demonstrated for growth, branching, mortality and reiteration processes, and for different root architectures. Plugin examples demonstrate the model's versatility at simulating plastic responses to environmental constraints. Outputs of the model include diverse root system structures such as tap-root, fasciculate, tuberous, nodulated and clustered root systems. DigR is based on plant architecture analysis which leads to specific root type classification and organization that are directly linked to field measurements. The open source simulator of the model has been included within a friendly user environment. DigR accuracy and versatility are demonstrated for growth simulations of complex root systems for both annual and perennial plants.

Generic Stellarator-like Magnetic Fusion Reactor

NASA Astrophysics Data System (ADS)

Sheffield, John; Spong, Donald

2015-11-01

The Generic Magnetic Fusion Reactor paper, published in 1985, has been updated, reflecting the improved science and technology base in the magnetic fusion program. Key changes beyond inflation are driven by important benchmark numbers for technologies and costs from ITER construction, and the use of a more conservative neutron wall flux and fluence in modern fusion reactor designs. In this paper the generic approach is applied to a catalyzed D-D stellarator-like reactor. It is shown that an interesting power plant might be possible if the following parameters could be achieved for a reference reactor: R/ < a > ~ 4 , confinement factor, fren = 0.9-1.15, < β > ~ 8 . 0 -11.5 %, Zeff ~ 1.45 plus a relativistic temperature correction, fraction of fast ions lost ~ 0.07, Bm ~ 14-16 T, and R ~ 18-24 m. J. Sheffield was supported under ORNL subcontract 4000088999 with the University of Tennessee.

Computations of ideal and real gas high altitude plume flows

NASA Technical Reports Server (NTRS)

Feiereisen, William J.; Venkatapathy, Ethiraj

1988-01-01

In the present work, complete flow fields around generic space vehicles in supersonic and hypersonic flight regimes are studied numerically. Numerical simulation is performed with a flux-split, time asymptotic viscous flow solver that incorporates a generalized equilibrium chemistry model. Solutions to generic problems at various altitude and flight conditions show the complexity of the flow, the equilibrium chemical dissociation and its effect on the overall flow field. Viscous ideal gas solutions are compared against equilibrium gas solutions to illustrate the effect of equilibrium chemistry. Improved solution accuracy is achieved through adaptive grid refinement.

Spacecraft Trajectory Analysis and Mission Planning Simulation (STAMPS) Software

NASA Technical Reports Server (NTRS)

Puckett, Nancy; Pettinger, Kris; Hallstrom,John; Brownfield, Dana; Blinn, Eric; Williams, Frank; Wiuff, Kelli; McCarty, Steve; Ramirez, Daniel; Lamotte, Nicole;

Incorporating a Generic Model of Subcutaneous Insulin Absorption into the AIDA v4 Diabetes Simulator 3. Early Plasma Insulin Determinations

PubMed Central

Lehmann, Eldon D.; Tarín, Cristina; Bondia, Jorge; Teufel, Edgar; Deutsch, Tibor

2009-01-01

Introduction AIDA is an interactive educational diabetes simulator that has been available without charge via the Internet for over 12 years. Recent articles have described the incorporation of a novel generic model of insulin absorption into AIDA as a way of enhancing its capabilities. The basic model components to be integrated have been overviewed, with the aim being to provide simulations of regimens utilizing insulin analogues, as well as insulin doses greater than 40 IU (the current upper limit within the latest release of AIDA [v4.3a]). Some preliminary calculated insulin absorption results have also recently been described. Methods This article presents the first simulated plasma insulin profiles from the integration of the generic subcutaneous insulin absorption model, and the currently implemented model in AIDA for insulin disposition. Insulin absorption has been described by the physiologically based model of Tarín and colleagues. A single compartment modeling approach has been used to specify how absorbed insulin is distributed in, and eliminated from, the human body. To enable a numerical solution of the absorption model, a spherical subcutaneous depot for the injected insulin dose has been assumed and spatially discretized into shell compartments with homogeneous concentrations, having as its center the injection site. The number of these compartments will depend on the dose and type of insulin. Insulin inflow arises as the sum of contributions to the different shells. For this report the first bench testing of plasma insulin determinations has been done. Results Simulated plasma insulin profiles are provided for currently available insulin preparations, including a rapidly acting insulin analogue (e.g., lispro/Humalog or aspart/Novolog), a short-acting (regular) insulin preparation (e.g., Actrapid), intermediate-acting insulins (both Semilente and neutral protamine Hagedorn types), and a very long-acting insulin analogue (e.g., glargine/Lantus), as well as for insulin doses up to 50 IU. Discussion The methodology to be adopted for implementing the generic absorption model within AIDA has been overviewed, and the first plasma insulin profiles based on this approach have been demonstrated. Ideas for future work and development are discussed. It is expected that an updated release of AIDA (v4.5), based on this collaborative approach, will become available for free—in due course—via the www.2aida.org Web site. Readers who wish to be informed when the new software is launched can join the very low volume AIDA announcement list by sending a blank email note to subscribe@2aida.org. PMID:20046665

A generic, cost-effective, and scalable cell lineage analysis platform

PubMed Central

Biezuner, Tamir; Spiro, Adam; Raz, Ofir; Amir, Shiran; Milo, Lilach; Adar, Rivka; Chapal-Ilani, Noa; Berman, Veronika; Fried, Yael; Ainbinder, Elena; Cohen, Galit; Barr, Haim M.; Halaban, Ruth; Shapiro, Ehud

2016-01-01

Advances in single-cell genomics enable commensurate improvements in methods for uncovering lineage relations among individual cells. Current sequencing-based methods for cell lineage analysis depend on low-resolution bulk analysis or rely on extensive single-cell sequencing, which is not scalable and could be biased by functional dependencies. Here we show an integrated biochemical-computational platform for generic single-cell lineage analysis that is retrospective, cost-effective, and scalable. It consists of a biochemical-computational pipeline that inputs individual cells, produces targeted single-cell sequencing data, and uses it to generate a lineage tree of the input cells. We validated the platform by applying it to cells sampled from an ex vivo grown tree and analyzed its feasibility landscape by computer simulations. We conclude that the platform may serve as a generic tool for lineage analysis and thus pave the way toward large-scale human cell lineage discovery. PMID:27558250

Heat conduction in a chain of colliding particles with a stiff repulsive potential

NASA Astrophysics Data System (ADS)

Gendelman, Oleg V.; Savin, Alexander V.

2016-11-01

One-dimensional billiards, i.e., a chain of colliding particles with equal masses, is a well-known example of a completely integrable system. Billiards with different particle masses is generically not integrable, but it still exhibits divergence of a heat conduction coefficient (HCC) in the thermodynamic limit. Traditional billiards models imply instantaneous (zero-time) collisions between the particles. We relax this condition of instantaneous impact and consider heat transport in a chain of stiff colliding particles with the power-law potential of the nearest-neighbor interaction. The instantaneous collisions correspond to the limit of infinite power in the interaction potential; for finite powers, the interactions take nonzero time. This modification of the model leads to a profound physical consequence—the probability of multiple (in particular triple) -particle collisions becomes nonzero. Contrary to the integrable billiards of equal particles, the modified model exhibits saturation of the heat conduction coefficient for a large system size. Moreover, the identification of scattering events with triple-particle collisions leads to a simple definition of the characteristic mean free path and a kinetic description of heat transport. This approach allows us to predict both the temperature and density dependencies for the HCC limit values. The latter dependence is quite counterintuitive—the HCC is inversely proportional to the particle density in the chain. Both predictions are confirmed by direct numerical simulations.

Simulation validation of the XV-15 tilt-rotor research aircraft

NASA Technical Reports Server (NTRS)

Ferguson, S. W.; Hanson, G. D.; Churchill, G. B.

1984-01-01

The results of a simulation validation program of the XV-15 tilt-rotor research aircraft are detailed, covering such simulation aspects as the mathematical model, visual system, motion system, cab aural system, cab control loader system, pilot perceptual fidelity, and generic tilt rotor applications. Simulation validation was performed for the hover, low-speed, and sideward flight modes, with consideration of the in-ground rotor effect. Several deficiencies of the mathematical model and the simulation systems were identified in the course of the simulation validation project, and some were corrected. It is noted that NASA's Vertical Motion Simulator used in the program is an excellent tool for tilt-rotor and rotorcraft design, development, and pilot training.

Development of a Turbofan Engine Simulation in a Graphical Simulation Environment

NASA Technical Reports Server (NTRS)

Parker, Khary I.; Guo, Ten-Heui

2003-01-01

This paper presents the development of a generic component level model of a turbofan engine simulation with a digital controller, in an advanced graphical simulation environment. The goal of this effort is to develop and demonstrate a flexible simulation platform for future research in propulsion system control and diagnostic technology. A previously validated FORTRAN-based model of a modern, high-performance, military-type turbofan engine is being used to validate the platform development. The implementation process required the development of various innovative procedures, which are discussed in the paper. Open-loop and closed-loop comparisons are made between the two simulations. Future enhancements that are to be made to the modular engine simulation are summarized.

Evaluation of automated decisionmaking methodologies and development of an integrated robotic system simulation

NASA Technical Reports Server (NTRS)

Haley, D. C.; Almand, B. J.; Thomas, M. M.; Krauze, L. D.; Gremban, K. D.; Sanborn, J. C.; Kelly, J. H.; Depkovich, T. M.

1984-01-01

A generic computer simulation for manipulator systems (ROBSIM) was implemented and the specific technologies necessary to increase the role of automation in various missions were developed. The specific items developed are: (1) capability for definition of a manipulator system consisting of multiple arms, load objects, and an environment; (2) capability for kinematic analysis, requirements analysis, and response simulation of manipulator motion; (3) postprocessing options such as graphic replay of simulated motion and manipulator parameter plotting; (4) investigation and simulation of various control methods including manual force/torque and active compliances control; (5) evaluation and implementation of three obstacle avoidance methods; (6) video simulation and edge detection; and (7) software simulation validation.

Alaska IPASS database preparation manual.

Treesearch

P. McHugh; D. Olson; C. Schallau

1989-01-01

Describes the data, their sources, and the calibration procedures used in compiling a database for the Alaska IPASS (interactive policy analysis simulation system) model. Although this manual is for Alaska, it provides generic instructions for analysts preparing databases for other geographical areas.

In-flight performance optimization for rotorcraft with redundant controls

NASA Astrophysics Data System (ADS)

Ozdemir, Gurbuz Taha

A conventional helicopter has limits on performance at high speeds because of the limitations of main rotor, such as compressibility issues on advancing side or stall issues on retreating side. Auxiliary lift and thrust components have been suggested to improve performance of the helicopter substantially by reducing the loading on the main rotor. Such a configuration is called the compound rotorcraft. Rotor speed can also be varied to improve helicopter performance. In addition to improved performance, compound rotorcraft and variable RPM can provide a much larger degree of control redundancy. This additional redundancy gives the opportunity to further enhance performance and handling qualities. A flight control system is designed to perform in-flight optimization of redundant control effectors on a compound rotorcraft in order to minimize power required and extend range. This "Fly to Optimal" (FTO) control law is tested in simulation using the GENHEL model. A model of the UH-60, a compound version of the UH-60A with lifting wing and vectored thrust ducted propeller (VTDP), and a generic compound version of the UH-60A with lifting wing and propeller were developed and tested in simulation. A model following dynamic inversion controller is implemented for inner loop control of roll, pitch, yaw, heave, and rotor RPM. An outer loop controller regulates airspeed and flight path during optimization. A Golden Section search method was used to find optimal rotor RPM on a conventional helicopter, where the single redundant control effector is rotor RPM. The FTO builds off of the Adaptive Performance Optimization (APO) method of Gilyard by performing low frequency sweeps on a redundant control for a fixed wing aircraft. A method based on the APO method was used to optimize trim on a compound rotorcraft with several redundant control effectors. The controller can be used to optimize rotor RPM and compound control effectors through flight test or simulations in order to establish a schedule. The method has been expanded to search a two-dimensional control space. Simulation results demonstrate the ability to maximize range by optimizing stabilator deflection and an airspeed set point. Another set of results minimize power required in high speed flight by optimizing collective pitch and stabilator deflection. Results show that the control laws effectively hold the flight condition while the FTO method is effective at improving performance. Optimizations show there can be issues when the control laws regulating altitude push the collective control towards it limits. So a modification was made to the control law to regulate airspeed and altitude using propeller pitch and angle of attack while the collective is held fixed or used as an optimization variable. A dynamic trim limit avoidance algorithm is applied to avoid control saturation in other axes during optimization maneuvers. Range and power optimization FTO simulations are compared with comprehensive sweeps of trim solutions and FTO optimization shown to be effective and reliable in reaching an optimal when optimizing up to two redundant controls. Use of redundant controls is shown to be beneficial for improving performance. The search method takes almost 25 minutes of simulated flight for optimization to be complete. The optimization maneuver itself can sometimes drive the power required to high values, so a power limit is imposed to restrict the search to avoid conditions where power is more than5% higher than that of the initial trim state. With this modification, the time the optimization maneuver takes to complete is reduced down to 21 minutes without any significant change in the optimal power value.

Architecture Analysis of Wireless Power Transmission for Lunar Outposts

DTIC Science & Technology

2015-09-01

through his work on wireless communication using radio wave propagation for both transmitting and receiving high frequency electricity using a focusing...Administration nm nanometers NRC National Research Council PGT platform generic technologies PMAD power management and distribution RF radio frequency xiv...GHz (Marzwell 2008). While the slot antenna can handle frequencies between 70 GHz and 150 GHz, it has been optimized for 94 GHz and has a radio

Sampling ARG of multiple populations under complex configurations of subdivision and admixture.

PubMed

Carrieri, Anna Paola; Utro, Filippo; Parida, Laxmi

2016-04-01

Simulating complex evolution scenarios of multiple populations is an important task for answering many basic questions relating to population genomics. Apart from the population samples, the underlying Ancestral Recombinations Graph (ARG) is an additional important means in hypothesis checking and reconstruction studies. Furthermore, complex simulations require a plethora of interdependent parameters making even the scenario-specification highly non-trivial. We present an algorithm SimRA that simulates generic multiple population evolution model with admixture. It is based on random graphs that improve dramatically in time and space requirements of the classical algorithm of single populations.Using the underlying random graphs model, we also derive closed forms of expected values of the ARG characteristics i.e., height of the graph, number of recombinations, number of mutations and population diversity in terms of its defining parameters. This is crucial in aiding the user to specify meaningful parameters for the complex scenario simulations, not through trial-and-error based on raw compute power but intelligent parameter estimation. To the best of our knowledge this is the first time closed form expressions have been computed for the ARG properties. We show that the expected values closely match the empirical values through simulations.Finally, we demonstrate that SimRA produces the ARG in compact forms without compromising any accuracy. We demonstrate the compactness and accuracy through extensive experiments. SimRA (Simulation based on Random graph Algorithms) source, executable, user manual and sample input-output sets are available for downloading at: https://github.com/ComputationalGenomics/SimRA CONTACT: : parida@us.ibm.com Supplementary data are available at Bioinformatics online. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

A generic double-curvature piezoelectric shell energy harvester: Linear/nonlinear theory and applications

NASA Astrophysics Data System (ADS)

Zhang, X. F.; Hu, S. D.; Tzou, H. S.

2014-12-01

Converting vibration energy to useful electric energy has attracted much attention in recent years. Based on the electromechanical coupling of piezoelectricity, distributed piezoelectric zero-curvature type (e.g., beams and plates) energy harvesters have been proposed and evaluated. The objective of this study is to develop a generic linear and nonlinear piezoelectric shell energy harvesting theory based on a double-curvature shell. The generic piezoelectric shell energy harvester consists of an elastic double-curvature shell and piezoelectric patches laminated on its surface(s). With a current model in the closed-circuit condition, output voltages and energies across a resistive load are evaluated when the shell is subjected to harmonic excitations. Steady-state voltage and power outputs across the resistive load are calculated at resonance for each shell mode. The piezoelectric shell energy harvesting mechanism can be simplified to shell (e.g., cylindrical, conical, spherical, paraboloidal, etc.) and non-shell (beam, plate, ring, arch, etc.) distributed harvesters using two Lamé parameters and two curvature radii of the selected harvester geometry. To demonstrate the utility and simplification procedures, the generic linear/nonlinear shell energy harvester mechanism is simplified to three specific structures, i.e., a cantilever beam case, a circular ring case and a conical shell case. Results show the versatility of the generic linear/nonlinear shell energy harvesting mechanism and the validity of the simplification procedures.

On the relevance of modeling viscoelastic bending behavior in finite element forming simulation of continuously fiber reinforced thermoplastics

NASA Astrophysics Data System (ADS)

Dörr, Dominik; Schirmaier, Fabian J.; Henning, Frank; Kärger, Luise

2017-10-01

Finite Element (FE) forming simulation offers the possibility of a detailed analysis of the deformation behavior of multilayered thermoplastic blanks during forming, considering material behavior and process conditions. Rate-dependent bending behavior is a material characteristic, which is so far not considered in FE forming simulation of pre-impregnated, continuously fiber reinforced polymers (CFRPs). Therefore, an approach for modeling viscoelastic bending behavior in FE composite forming simulation is presented in this work. The presented approach accounts for the distinct rate-dependent bending behavior of e.g. thermoplastic CFRPs at process conditions. The approach is based on a Voigt-Kelvin (VK) and a generalized Maxwell (GM) approach, implemented within a FE forming simulation framework implemented in several user-subroutines of the commercially available FE solver Abaqus. The VK, GM, as well as purely elastic bending modeling approaches are parameterized according to dynamic bending characterization results for a PA6-CF UD-tape. It is found that only the GM approach is capable to represent the bending deformation characteristic for all of the considered bending deformation rates. The parameterized bending modeling approaches are applied to a hemisphere test and to a generic geometry. A comparison of the forming simulation results of the generic geometry to experimental tests show a good agreement between simulation and experiments. Furthermore, the simulation results reveal that especially a correct modeling of the initial bending stiffness is relevant for the prediction of wrinkling behavior, as a similar onset of wrinkles is observed for the GM, the VK and an elastic approach, fitted to the stiffness observed in the dynamic rheometer test for low curvatures. Hence, characterization and modeling of rate-dependent bending behavior is crucial for FE forming simulation of thermoplastic CFRPs.

KINEXP: Computer Simulation in Enzyme Kinetics.

ERIC Educational Resources Information Center

Gelpi, Josep Lluis; Domenech, Carlos

1988-01-01

Describes a program which allows students to identify and characterize several kinetic inhibitory mechanisms. Uses the generic model of reversible inhibition of a monosubstrate enzyme but can be easily modified to run other models such as bisubstrate enzymes. Uses MS-DOS BASIC. (MVL)

Taming Log Files from Game/Simulation-Based Assessments: Data Models and Data Analysis Tools. Research Report. ETS RR-16-10

ERIC Educational Resources Information Center

Hao, Jiangang; Smith, Lawrence; Mislevy, Robert; von Davier, Alina; Bauer, Malcolm

2016-01-01

Extracting information efficiently from game/simulation-based assessment (G/SBA) logs requires two things: a well-structured log file and a set of analysis methods. In this report, we propose a generic data model specified as an extensible markup language (XML) schema for the log files of G/SBAs. We also propose a set of analysis methods for…

Loading relativistic Maxwell distributions in particle simulations

NASA Astrophysics Data System (ADS)

Zenitani, Seiji

2015-04-01

Numerical algorithms to load relativistic Maxwell distributions in particle-in-cell (PIC) and Monte-Carlo simulations are presented. For stationary relativistic Maxwellian, the inverse transform method and the Sobol algorithm are reviewed. To boost particles to obtain relativistic shifted-Maxwellian, two rejection methods are proposed in a physically transparent manner. Their acceptance efficiencies are ≈50 % for generic cases and 100% for symmetric distributions. They can be combined with arbitrary base algorithms.

Multiverse data-flow control.

PubMed

Schindler, Benjamin; Waser, Jürgen; Ribičić, Hrvoje; Fuchs, Raphael; Peikert, Ronald

2013-06-01

In this paper, we present a data-flow system which supports comparative analysis of time-dependent data and interactive simulation steering. The system creates data on-the-fly to allow for the exploration of different parameters and the investigation of multiple scenarios. Existing data-flow architectures provide no generic approach to handle modules that perform complex temporal processing such as particle tracing or statistical analysis over time. Moreover, there is no solution to create and manage module data, which is associated with alternative scenarios. Our solution is based on generic data-flow algorithms to automate this process, enabling elaborate data-flow procedures, such as simulation, temporal integration or data aggregation over many time steps in many worlds. To hide the complexity from the user, we extend the World Lines interaction techniques to control the novel data-flow architecture. The concept of multiple, special-purpose cursors is introduced to let users intuitively navigate through time and alternative scenarios. Users specify only what they want to see, the decision which data are required is handled automatically. The concepts are explained by taking the example of the simulation and analysis of material transport in levee-breach scenarios. To strengthen the general applicability, we demonstrate the investigation of vortices in an offline-simulated dam-break data set.

Propulsion System Simulation Using the Toolbox for the Modeling and Analysis of Thermodynamic System (T-MATS)

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Lavelle, Thomas M.; May, Ryan D.; Litt, Jonathan S.; Guo, Ten-Huei (OA)

2014-01-01

A simulation toolbox has been developed for the creation of both steady-state and dynamic thermodynamic software models. This presentation describes the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS), which combines generic thermodynamic and controls modeling libraries with a numerical iterative solver to create a framework for the development of thermodynamic system simulations, such as gas turbine engines. The objective of this presentation is to present an overview of T-MATS, the theory used in the creation of the module sets, and a possible propulsion simulation architecture.

DEFINITIVE SOX CONTROL PROCESS EVALUATIONS: LIMESTONE, DOUBLE ALKALI, AND CITRATE FGD PROCESSES

EPA Science Inventory

The report gives results of a detailed comparative technical and economic evaluation of limestone slurry, generic double alkali, and citrate flue gas desulfurization (FGD) processes, assuming proven technology and using representative power plant, process design, and economic pre...

78 FR 23684 - Personnel Access Authorization Requirements for Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-22

... Nuclear Energy Institute (NEI or the petitioner) on January 25, 2013. The petition was docketed by the NRC... affecting the nuclear energy industry, including the regulatory aspects of generic operational and technical... 22, 2013 / Proposed Rules#0;#0; [[Page 23684

Impact of Site Elevation on Mg Smelter Design

NASA Astrophysics Data System (ADS)

Baker, Phillip W.

Site elevation has many surprising and significant impacts on the engineering design of metallurgical plant of all types. Electrolytic magnesium smelters maybe built at high elevation for a variety of reasons including availability of raw material, energy or electric power. Because of the unit processes they typically involve, Mg smelters can be extensively impacted by site elevation. In this paper, generic examples of the design changes required to adapt a smelter originally designed for sea level to operate at 2700 m are presented. While the examples are drawn from a magnesium plant design case, these changes are generically applicable to all industrial plants utilizing similar unit processes irrespective of product.

Requirements analysis notebook for the flight data systems definition in the Real-Time Systems Engineering Laboratory (RSEL)

NASA Astrophysics Data System (ADS)

Wray, Richard B.

1991-12-01

A hybrid requirements analysis methodology was developed, based on the practices actually used in developing a Space Generic Open Avionics Architecture. During the development of this avionics architecture, a method of analysis able to effectively define the requirements for this space avionics architecture was developed. In this methodology, external interfaces and relationships are defined, a static analysis resulting in a static avionics model was developed, operating concepts for simulating the requirements were put together, and a dynamic analysis of the execution needs for the dynamic model operation was planned. The systems engineering approach was used to perform a top down modified structured analysis of a generic space avionics system and to convert actual program results into generic requirements. CASE tools were used to model the analyzed system and automatically generate specifications describing the model's requirements. Lessons learned in the use of CASE tools, the architecture, and the design of the Space Generic Avionics model were established, and a methodology notebook was prepared for NASA. The weaknesses of standard real-time methodologies for practicing systems engineering, such as Structured Analysis and Object Oriented Analysis, were identified.

Requirements analysis notebook for the flight data systems definition in the Real-Time Systems Engineering Laboratory (RSEL)

NASA Technical Reports Server (NTRS)

Wray, Richard B.

1991-01-01

A hybrid requirements analysis methodology was developed, based on the practices actually used in developing a Space Generic Open Avionics Architecture. During the development of this avionics architecture, a method of analysis able to effectively define the requirements for this space avionics architecture was developed. In this methodology, external interfaces and relationships are defined, a static analysis resulting in a static avionics model was developed, operating concepts for simulating the requirements were put together, and a dynamic analysis of the execution needs for the dynamic model operation was planned. The systems engineering approach was used to perform a top down modified structured analysis of a generic space avionics system and to convert actual program results into generic requirements. CASE tools were used to model the analyzed system and automatically generate specifications describing the model's requirements. Lessons learned in the use of CASE tools, the architecture, and the design of the Space Generic Avionics model were established, and a methodology notebook was prepared for NASA. The weaknesses of standard real-time methodologies for practicing systems engineering, such as Structured Analysis and Object Oriented Analysis, were identified.

Evaluation of the True Wavefront Aberrations in Eyes Implanted With a Rotationally Asymmetric Multifocal Intraocular Lens.

PubMed

Akondi, Vyas; Pérez-Merino, Pablo; Martinez-Enriquez, Eduardo; Dorronsoro, Carlos; Alejandre, Nicolás; Jiménez-Alfaro, Ignacio; Marcos, Susana

2017-04-01

Standard evaluation of aberrations from wavefront slope measurements in patients implanted with a rotationally asymmetric multifocal intraocular lens (IOL), the Lentis Mplus (Oculentis GmbH, Berlin, Germany), results in large magnitude primary vertical coma, which is attributed to the intrinsic IOL design. The new proposed method analyzes aberrometry data, allowing disentangling the IOL power pupillary distribution from the true higher order aberrations of the eye. The new method of wavefront reconstruction uses retinal spots obtained at both the near and far foci. The method was tested using ray tracing optical simulations in a computer eye model virtually implanted with the Lentis Mplus IOL, with a generic cornea or with anterior segment geometry obtained from custom quantitative spectral-domain optical coherence tomography in a real patient. The method was applied to laser ray tracing aberrometry data at near and far fixation obtained in a patient implanted with the Lentis Mplus IOL. Higher order aberrations evaluated from simulated and real retinal spot diagrams following the new reconstruction approach matched the nominal aberrations (approximately 98%). Previously reported primary vertical coma in patients implanted with this IOL lost significance with the application of the proposed reconstruction. Custom analysis of ray tracing-based retinal spot diagrams allowed decoupling of the true higher order aberrations of the patient's eye from the power pupillary distribution of a rotationally asymmetric multifocal IOL, therefore providing the appropriate phase map to accurately evaluate through-focus optical quality. [J Refract Surg. 2017;33(4):257-265.]. Copyright 2017, SLACK Incorporated.

An Aerodynamic Analysis of a Spinning Missile with Dithering Canards

NASA Technical Reports Server (NTRS)

Meakin, Robert L.; Nygaard, Tor A.

2003-01-01

A generic spinning missile with dithering canards is used to demonstrate the utility of an overset structured grid approach for simulating the aerodynamics of rolling airframe missile systems. The approach is used to generate a modest aerodynamic database for the generic missile. The database is populated with solutions to the Euler and Navier-Stokes equations. It is used to evaluate grid resolution requirements for accurate prediction of instantaneous missile loads and the relative aerodynamic significance of angle-of-attack, canard pitching sequence, viscous effects, and roll-rate effects. A novel analytical method for inter- and extrapolation of database results is also given.

Explore or Exploit? A Generic Model and an Exactly Solvable Case

NASA Astrophysics Data System (ADS)

Gueudré, Thomas; Dobrinevski, Alexander; Bouchaud, Jean-Philippe

2014-02-01

Finding a good compromise between the exploitation of known resources and the exploration of unknown, but potentially more profitable choices, is a general problem, which arises in many different scientific disciplines. We propose a stylized model for these exploration-exploitation situations, including population or economic growth, portfolio optimization, evolutionary dynamics, or the problem of optimal pinning of vortices or dislocations in disordered materials. We find the exact growth rate of this model for treelike geometries and prove the existence of an optimal migration rate in this case. Numerical simulations in the one-dimensional case confirm the generic existence of an optimum.

Size reduction techniques for vital compliant VHDL simulation models

DOEpatents

Rich, Marvin J.; Misra, Ashutosh

2006-08-01

A method and system select delay values from a VHDL standard delay file that correspond to an instance of a logic gate in a logic model. Then the system collects all the delay values of the selected instance and builds super generics for the rise-time and the fall-time of the selected instance. Then, the system repeats this process for every delay value in the standard delay file (310) that correspond to every instance of every logic gate in the logic model. The system then outputs a reduced size standard delay file (314) containing the super generics for every instance of every logic gate in the logic model.

Explore or exploit? A generic model and an exactly solvable case.

PubMed

Gueudré, Thomas; Dobrinevski, Alexander; Bouchaud, Jean-Philippe

2014-02-07

Finding a good compromise between the exploitation of known resources and the exploration of unknown, but potentially more profitable choices, is a general problem, which arises in many different scientific disciplines. We propose a stylized model for these exploration-exploitation situations, including population or economic growth, portfolio optimization, evolutionary dynamics, or the problem of optimal pinning of vortices or dislocations in disordered materials. We find the exact growth rate of this model for treelike geometries and prove the existence of an optimal migration rate in this case. Numerical simulations in the one-dimensional case confirm the generic existence of an optimum.

Development and validation of a generic finite element vehicle buck model for the analysis of driver rib fractures in real life nearside oblique frontal crashes.

PubMed

Iraeus, Johan; Lindquist, Mats

2016-10-01

Frontal crashes still account for approximately half of all fatalities in passenger cars, despite several decades of crash-related research. For serious injuries in this crash mode, several authors have listed the thorax as the most important. Computer simulation provides an effective tool to study crashes and evaluate injury mechanisms, and using stochastic input data, whole populations of crashes can be studied. The aim of this study was to develop a generic buck model and to validate this model on a population of real-life frontal crashes in terms of the risk of rib fracture. The study was conducted in four phases. In the first phase, real-life validation data were derived by analyzing NASS/CDS data to find the relationship between injury risk and crash parameters. In addition, available statistical distributions for the parameters were collected. In the second phase, a generic parameterized finite element (FE) model of a vehicle interior was developed based on laser scans from the A2MAC1 database. In the third phase, model parameters that could not be found in the literature were estimated using reverse engineering based on NCAP tests. Finally, in the fourth phase, the stochastic FE model was used to simulate a population of real-life crashes, and the result was compared to the validation data from phase one. The stochastic FE simulation model overestimates the risk of rib fracture, more for young occupants and less for senior occupants. However, if the effect of underestimation of rib fractures in the NASS/CDS material is accounted for using statistical simulations, the risk of rib fracture based on the stochastic FE model matches the risk based on the NASS/CDS data for senior occupants. The current version of the stochastic model can be used to evaluate new safety measures using a population of frontal crashes for senior occupants. Copyright © 2016 Elsevier Ltd. All rights reserved.

Generic Vehicle Speed Models Based On Traffic Simulation: Development and Application (Revision #1)

DOT National Transportation Integrated Search

1994-12-15

The findings of a research project to develop new methods of estimating speeds for inclusion in the Highway Performance Monitoring System (HPMS) Analytical Process are summarized. The paper focuses on the effects of traffic conditions excluding incid...

Porting LAMMPS to GPUs.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, William Michael; Plimpton, Steven James; Wang, Peng

2010-03-01

LAMMPS is a classical molecular dynamics code, and an acronym for Large-scale Atomic/Molecular Massively Parallel Simulator. LAMMPS has potentials for soft materials (biomolecules, polymers) and solid-state materials (metals, semiconductors) and coarse-grained or mesoscopic systems. It can be used to model atoms or, more generically, as a parallel particle simulator at the atomic, meso, or continuum scale. LAMMPS runs on single processors or in parallel using message-passing techniques and a spatial-decomposition of the simulation domain. The code is designed to be easy to modify or extend with new functionality.

Doing accelerator physics using SDDS, UNIX, and EPICS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Borland, M.; Emery, L.; Sereno, N.

1995-12-31

The use of the SDDS (Self-Describing Data Sets) file protocol, together with the UNIX operating system and EPICS (Experimental Physics and Industrial Controls System), has proved powerful during the commissioning of the APS (Advanced Photon Source) accelerator complex. The SDDS file protocol has permitted a tool-oriented approach to developing applications, wherein generic programs axe written that function as part of multiple applications. While EPICS-specific tools were written for data collection, automated experiment execution, closed-loop control, and so forth, data processing and display axe done with the SDDS Toolkit. Experiments and data reduction axe implemented as UNIX shell scripts that coordinatemore » the execution of EPICS specific tools and SDDS tools. Because of the power and generic nature of the individual tools and of the UNIX shell environment, automated experiments can be prepared and executed rapidly in response to unanticipated needs or new ideas. Examples are given of application of this methodology to beam motion characterization, beam-position-monitor offset measurements, and klystron characterization.« less

Drug policy and administration affecting quality of life of the poor in Thailand.

PubMed

Prutipinyo, Chardsumon; Sirichotiratana, Nithat

2011-09-01

This study aims to analyze drug policy and administration affecting quality of life of the poor in Thailand. Review of official reports and related documents, for the past 10 years (from 2000-2010). By imposing compulsory licensing, the Thai government maintains negotiating power over the price of pharmaceutical products with the patent holders of the original drugs. This gives an opportunity for relevant government agencies to produce or import patented drugs. At present, there are many problems and obstacles. The findings show that developing countries need to strengthen their negotiating power so that the pharmaceutical manufacturers cannot take advantage through mechanisms provided for such as compulsory licensing and provisions for flexibility in Trade-Related Intellectual Property Rights (TRIPS) agreement. Furthermore, these countries must support and empower the local pharmaceutical manufacturers to produce generic drugs. Developing countries should ensure that their populations have confidence in universal coverage service and medical systems regarding the quality of generic drugs.

A generic model to simulate air-borne diseases as a function of crop architecture.

PubMed

Casadebaig, Pierre; Quesnel, Gauthier; Langlais, Michel; Faivre, Robert

2012-01-01

In a context of pesticide use reduction, alternatives to chemical-based crop protection strategies are needed to control diseases. Crop and plant architectures can be viewed as levers to control disease outbreaks by affecting microclimate within the canopy or pathogen transmission between plants. Modeling and simulation is a key approach to help analyze the behaviour of such systems where direct observations are difficult and tedious. Modeling permits the joining of concepts from ecophysiology and epidemiology to define structures and functions generic enough to describe a wide range of epidemiological dynamics. Additionally, this conception should minimize computing time by both limiting the complexity and setting an efficient software implementation. In this paper, our aim was to present a model that suited these constraints so it could first be used as a research and teaching tool to promote discussions about epidemic management in cropping systems. The system was modelled as a combination of individual hosts (population of plants or organs) and infectious agents (pathogens) whose contacts are restricted through a network of connections. The system dynamics were described at an individual scale. Additional attention was given to the identification of generic properties of host-pathogen systems to widen the model's applicability domain. Two specific pathosystems with contrasted crop architectures were considered: ascochyta blight on pea (homogeneously layered canopy) and potato late blight (lattice of individualized plants). The model behavior was assessed by simulation and sensitivity analysis and these results were discussed against the model ability to discriminate between the defined types of epidemics. Crop traits related to disease avoidance resulting in a low exposure, a slow dispersal or a de-synchronization of plant and pathogen cycles were shown to strongly impact the disease severity at the crop scale.

A Feasibility Study of Life-Extending Controls for Aircraft Turbine Engines Using a Generic Air Force Model (Preprint)

DTIC Science & Technology

2006-12-01

intelligent control algorithm embedded in the FADEC . This paper evaluates the LEC, based on critical components research, to demonstrate how an...control action, engine component life usage, and designing an intelligent control algorithm embedded in the FADEC . This paper evaluates the LEC, based on...simulation code for each simulator. One is typically configured to operate as a Full- Authority Digital Electronic Controller ( FADEC

Distributed decision-making in electric power system transmission maintenance scheduling using multi-agent systems (MAS)

NASA Astrophysics Data System (ADS)

Zhang, Zhong

In this work, motivated by the need to coordinate transmission maintenance scheduling among a multiplicity of self-interested entities in restructured power industry, a distributed decision support framework based on multiagent negotiation systems (MANS) is developed. An innovative risk-based transmission maintenance optimization procedure is introduced. Several models for linking condition monitoring information to the equipment's instantaneous failure probability are presented, which enable quantitative evaluation of the effectiveness of maintenance activities in terms of system cumulative risk reduction. Methodologies of statistical processing, equipment deterioration evaluation and time-dependent failure probability calculation are also described. A novel framework capable of facilitating distributed decision-making through multiagent negotiation is developed. A multiagent negotiation model is developed and illustrated that accounts for uncertainty and enables social rationality. Some issues of multiagent negotiation convergence and scalability are discussed. The relationships between agent-based negotiation and auction systems are also identified. A four-step MAS design methodology for constructing multiagent systems for power system applications is presented. A generic multiagent negotiation system, capable of inter-agent communication and distributed decision support through inter-agent negotiations, is implemented. A multiagent system framework for facilitating the automated integration of condition monitoring information and maintenance scheduling for power transformers is developed. Simulations of multiagent negotiation-based maintenance scheduling among several independent utilities are provided. It is shown to be a viable alternative solution paradigm to the traditional centralized optimization approach in today's deregulated environment. This multiagent system framework not only facilitates the decision-making among competing power system entities, but also provides a tool to use in studying competitive industry relative to monopolistic industry.

The water-energy-climate nexus: Resources and policy outlook for aquifers in Mexico

NASA Astrophysics Data System (ADS)

Scott, Christopher A.

2011-06-01

Three interlinked processes drive groundwater balances in diverse regions globally: (1) groundwater-irrigation intensification, (2) electrical energy supply for agriculture, and (3) climatic variability. Mexico's water-energy-climate nexus offers generic lessons because of its water scarcity and institutional reforms followed in other emerging economies. This paper analyzes data for 280 aquifers in Mexico, all registered water users, population projections, 2010-2100 precipitation and temperature projections for A1B and A2 emissions scenarios from 15 general circulation models, and 1999-2009 agricultural electricity use. Under A2 emissions, aquifers with negative balances will increase from 92 to 130 in number between 2010 and 2100, and the national groundwater deficit will increase by 21.3 km3. Under A2 and medium-variant population growth (which peaks midcentury), negative-balance aquifers will increase from 92 to 133, and the national groundwater deficit will increase by 22.4 km3. Agricultural power pricing offers a nexus-based policy tool to address aquifer depletion, an opportunity that was lost with the 2003 reduction in nighttime tariffs. Under A2, medium-variant population, and simulated 2% real annual increases in agricultural power tariffs, negative-balance aquifers will increase from 92 to 111, and the national groundwater deficit will increase by 17.5 km3 between 2010 and 2100. Regulatory and user-based groundwater management initiatives indicate growing awareness of aquifer depletion; however, the long-term outlook points to continued depletion. This raises the need to harness nexus-based policy options, i.e., increasing agricultural power tariffs, eliminating reduced nighttime tariffs, enforcing legislation linking groundwater extraction to power use, and limiting new power connections for groundwater wells.

Piloted Simulation Assessment of the Impact of Flexible Structures on Handling Qualities of Generic Supersonic Aircraft

NASA Technical Reports Server (NTRS)

Stringer, Mary T.; Cowen, Brandon; Hoffler, Keith D.; Couch, Jesse C.; Ogburn, Marilyn E.; Diebler, Corey G.

2013-01-01

The NASA Langley Research Center Cockpit Motion Facility (CMF) was used to conduct a piloted simulation assessment of the impact of flexible structures on flying qualities. The CMF was used because of its relatively high bandwidth, six degree-of-freedom motion capability. Previous studies assessed and attempted to mitigate the effects of multiple dynamic aeroservoelastic modes (DASE). Those results indicated problems existed, but the specific cause and effect was difficult to ascertain. The goal of this study was to identify specific DASE frequencies, damping ratios, and gains that cause degradation in handling qualities. A generic aircraft simulation was developed and designed to have Cooper-Harper Level 1 handling qualities when flown without DASE models. A test matrix of thirty-six DASE modes was implemented. The modes had frequencies ranging from 1 to 3.5 Hz and were applied to each axis independently. Each mode consisted of a single axis, frequency, damping, and gain, and was evaluated individually by six subject pilots with test pilot backgrounds. Analysis completed to date suggests that a number of the DASE models evaluated degrade the handling qualities of this class of aircraft to an uncontrollable condition.

Medicine prices, availability, and affordability in 36 developing and middle-income countries: a secondary analysis.

PubMed

Cameron, A; Ewen, M; Ross-Degnan, D; Ball, D; Laing, R

2009-01-17

WHO and Health Action International (HAI) have developed a standardised method for surveying medicine prices, availability, affordability, and price components in low-income and middle-income countries. Here, we present a secondary analysis of medicine availability in 45 national and subnational surveys done using the WHO/HAI methodology. Data from 45 WHO/HAI surveys in 36 countries were adjusted for inflation or deflation and purchasing power parity. International reference prices from open international procurements for generic products were used as comparators. Results are presented for 15 medicines included in at least 80% of surveys and four individual medicines. Average public sector availability of generic medicines ranged from 29.4% to 54.4% across WHO regions. Median government procurement prices for 15 generic medicines were 1.11 times corresponding international reference prices, although purchasing efficiency ranged from 0.09 to 5.37 times international reference prices. Low procurement prices did not always translate into low patient prices. Private sector patients paid 9-25 times international reference prices for lowest-priced generic products and over 20 times international reference prices for originator products across WHO regions. Treatments for acute and chronic illness were largely unaffordable in many countries. In the private sector, wholesale mark-ups ranged from 2% to 380%, whereas retail mark-ups ranged from 10% to 552%. In countries where value added tax was applied to medicines, the amount charged varied from 4% to 15%. Overall, public and private sector prices for originator and generic medicines were substantially higher than would be expected if purchasing and distribution were efficient and mark-ups were reasonable. Policy options such as promoting generic medicines and alternative financing mechanisms are needed to increase availability, reduce prices, and improve affordability.

Dynamics of oscillating relativistic tori around Kerr black holes

NASA Astrophysics Data System (ADS)

Zanotti, Olindo; Font, José A.; Rezzolla, Luciano; Montero, Pedro J.

2005-02-01

We present a comprehensive numerical study of the dynamics of relativistic axisymmetric accretion tori with a power-law distribution of specific angular momentum orbiting in the background space-time of a Kerr black hole. By combining general relativistic hydrodynamics simulations with a linear perturbative approach we investigate the main dynamical properties of these objects over a large parameter space. The astrophysical implications of our results extend and improve two interesting results that have been recently reported in the literature. First, the induced quasi-periodic variation of the mass quadrupole moment makes relativistic tori of nuclear matter densities, as those formed during the last stages of binary neutron star mergers, promising sources of gravitational radiation, potentially detectable by interferometric instruments. Secondly, p-mode oscillations in relativistic tori of low rest-mass densities could be used to explain high-frequency quasi-periodic oscillations observed in X-ray binaries containing a black hole candidate under conditions more generic than those considered so far.

Pre-transition effects mediate forces of assembly between transmembrane proteins

DOE PAGES

Katira, Shachi; Mandadapu, Kranthi K.; Vaikuntanathan, Suriyanarayanan; ...

2016-02-24

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the membrane. Using large-scale molecular simulation, we show that a protein with hydrophobic thickness equal to that of the disordered phase embedded in an ordered bilayer stabilizes a microscopic order–disorder interface. The stiffness of that interface is finite. When two such proteins approach each other, they assemble because assembly reduces the net interfacial energy. Analogous to the hydrophobic effect, we refer to thismore » phenomenon as the 'orderphobic effect'. The effect is mediated by proximity to the order–disorder phase transition and the size and hydrophobic mismatch of the protein. The strength and range of forces arising from this effect are significantly larger than those that could arise from membrane elasticity for the membranes considered.« less

Investigation of Optimal Control Allocation for Gust Load Alleviation in Flight Control

NASA Technical Reports Server (NTRS)

Frost, Susan A.; Taylor, Brian R.; Bodson, Marc

2012-01-01

Advances in sensors and avionics computation power suggest real-time structural load measurements could be used in flight control systems for improved safety and performance. A conventional transport flight control system determines the moments necessary to meet the pilot's command, while rejecting disturbances and maintaining stability of the aircraft. Control allocation is the problem of converting these desired moments into control effector commands. In this paper, a framework is proposed to incorporate real-time structural load feedback and structural load constraints in the control allocator. Constrained optimal control allocation can be used to achieve desired moments without exceeding specified limits on monitored load points. Minimization of structural loads by the control allocator is used to alleviate gust loads. The framework to incorporate structural loads in the flight control system and an optimal control allocation algorithm will be described and then demonstrated on a nonlinear simulation of a generic transport aircraft with flight dynamics and static structural loads.

Lightweight filter architecture for energy efficient mobile vehicle localization based on a distributed acoustic sensor network.

PubMed

Kim, Keonwook

2013-08-23

The generic properties of an acoustic signal provide numerous benefits for localization by applying energy-based methods over a deployed wireless sensor network (WSN). However, the signal generated by a stationary target utilizes a significant amount of bandwidth and power in the system without providing further position information. For vehicle localization, this paper proposes a novel proximity velocity vector estimator (PVVE) node architecture in order to capture the energy from a moving vehicle and reject the signal from motionless automobiles around the WSN node. A cascade structure between analog envelope detector and digital exponential smoothing filter presents the velocity vector-sensitive output with low analog circuit and digital computation complexity. The optimal parameters in the exponential smoothing filter are obtained by analytical and mathematical methods for maximum variation over the vehicle speed. For stationary targets, the derived simulation based on the acoustic field parameters demonstrates that the system significantly reduces the communication requirements with low complexity and can be expected to extend the operation time considerably.

Pre-transition effects mediate forces of assembly between transmembrane proteins

PubMed Central

Katira, Shachi; Mandadapu, Kranthi K; Vaikuntanathan, Suriyanarayanan; Smit, Berend; Chandler, David

2016-01-01

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the membrane. Using large-scale molecular simulation, we show that a protein with hydrophobic thickness equal to that of the disordered phase embedded in an ordered bilayer stabilizes a microscopic order–disorder interface. The stiffness of that interface is finite. When two such proteins approach each other, they assemble because assembly reduces the net interfacial energy. Analogous to the hydrophobic effect, we refer to this phenomenon as the 'orderphobic effect'. The effect is mediated by proximity to the order–disorder phase transition and the size and hydrophobic mismatch of the protein. The strength and range of forces arising from this effect are significantly larger than those that could arise from membrane elasticity for the membranes considered. DOI: http://dx.doi.org/10.7554/eLife.13150.001 PMID:26910009

Analysis of Percent On-Cell Reformation of Methane in SOFC Stacks and the Effects on Thermal, Electrical, and Mechanical Performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Recknagle, Kurtis P.; Koeppel, Brian J.; Sun, Xin

2007-04-30

Numerical simulations were performed to determine the effect that varying the percent on-cell steam-methane reformation would have on the thermal, electrical, and mechanical performance of generic, planar solid oxide fuel cell stacks. The study was performed using three-dimensional model geometries for cross-, co-, and counter-flow configuration stacks of 10x10- and 20x20-cm cell sizes. The analysis predicted the stress and temperature difference would be minimized for the 10x10-cm counter- and cross-flow stacks when 40 to 50% of the reformation reaction occurred on the anode. Gross electrical power density was virtually unaffected by the reforming. The co-flow stack benefited most from themore » on-cell reforming and had the lowest anode stresses of the 20x20-cm stacks. The analyses also suggest that airflows associated with 15% air utilization may be required for cooling the larger (20x20-cm) stacks.« less

Managing emergencies and abnormal situations in air traffic control (part II): teamwork strategies.

PubMed

Malakis, Stathis; Kontogiannis, Tom; Kirwan, Barry

2010-07-01

Team performance has been studied in many safety-critical organizations including aviation, nuclear power plant, offshore oil platforms and health organizations. This study looks into teamwork strategies that air traffic controllers employ to manage emergencies and abnormal situations. Two field studies were carried out in the form of observations of simulator training in emergency and unusual scenarios of novices and experienced controllers. Teamwork strategies covered aspects of team orientation and coordination, information exchange, change management and error handling. Several performance metrics were used to rate the efficiency of teamwork and test the construct validity of a prototype model of teamwork. This is a companion study to an earlier investigation of taskwork strategies in the same field (part I) and contributes to the development of a generic model for Taskwork and Teamwork strategies in Emergencies in Air traffic Management (T(2)EAM). Suggestions are made on how to use T(2)EAM to develop training programs, assess team performance and improve mishap investigations. Copyright 2010 Elsevier Ltd. All rights reserved.

Preferred supplier contracts in post-patent prescription drug markets.

PubMed

Blankart, Carl Rudolf; Stargardt, Tom

2016-02-22

In recent years, the expiration of patents for large drug classes has increased the importance of post-patent drug markets. However, previous research has focused solely on patent drug markets. In this study, the authors evaluate the influence of preferred supplier contracts, the German approach to tendering, in post-patent drug markets using a hierarchical market share attraction model. The authors find that preferred supplier contracts are a powerful strategic instrument for generic manufacturers in a highly competitive environment. They quantify the effects of signing a preferred supplier contract and show that brand-name manufacturers are vulnerable to tendering. Therefore, brand-name manufacturers should readjust their strategies and consider including preferred supplier contracts in their marketing mix. In addition, the authors employ a simulation to demonstrate that a first-mover advantage might be gained from signing a preferred supplier contract. Furthermore, their results can be used as a blueprint for decision makers in the pharmaceutical industry to assess the market share effects of different contracting strategies regarding preferred supplier contracts.

Pre-transition effects mediate forces of assembly between transmembrane proteins

DOE PAGES

Katira, Sachi; Mandadapu, Kranthi K.; Vaikuntanathan, Suriyanarayanan; ...

2016-02-24

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the membrane. Using large-scale molecular simulation, we show that a protein with hydrophobic thickness equal to that of the disordered phase embedded in an ordered bilayer stabilizes a microscopic order-disorder interface. The stiffness of that interface is finite. When two such proteins approach each other, they assemble because assembly reduces the net interfacial energy. Analogous to the hydrophobic effect, we refer to thismore » phenomenon as the ‘orderphobic effect’. The effect is mediated by proximity to the order-disorder phase transition and the size and hydrophobic mismatch of the protein. Furthermore, the strength and range of forces arising from this effect are significantly larger than those that could arise from membrane elasticity for the membranes considered.« less

Pre-transition effects mediate forces of assembly between transmembrane proteins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katira, Shachi; Mandadapu, Kranthi K.; Vaikuntanathan, Suriyanarayanan

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the membrane. Using large-scale molecular simulation, we show that a protein with hydrophobic thickness equal to that of the disordered phase embedded in an ordered bilayer stabilizes a microscopic order–disorder interface. The stiffness of that interface is finite. When two such proteins approach each other, they assemble because assembly reduces the net interfacial energy. Analogous to the hydrophobic effect, we refer to thismore » phenomenon as the 'orderphobic effect'. The effect is mediated by proximity to the order–disorder phase transition and the size and hydrophobic mismatch of the protein. The strength and range of forces arising from this effect are significantly larger than those that could arise from membrane elasticity for the membranes considered.« less

Pre-transition effects mediate forces of assembly between transmembrane proteins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katira, Sachi; Mandadapu, Kranthi K.; Vaikuntanathan, Suriyanarayanan

We present a mechanism for a generic, powerful force of assembly and mobility for transmembrane proteins in lipid bilayers. This force is a pre-transition (or pre-melting) effect for the first-order transition between ordered and disordered phases in the membrane. Using large-scale molecular simulation, we show that a protein with hydrophobic thickness equal to that of the disordered phase embedded in an ordered bilayer stabilizes a microscopic order-disorder interface. The stiffness of that interface is finite. When two such proteins approach each other, they assemble because assembly reduces the net interfacial energy. Analogous to the hydrophobic effect, we refer to thismore » phenomenon as the ‘orderphobic effect’. The effect is mediated by proximity to the order-disorder phase transition and the size and hydrophobic mismatch of the protein. Furthermore, the strength and range of forces arising from this effect are significantly larger than those that could arise from membrane elasticity for the membranes considered.« less

MQ-MAC: A Multi-Constrained QoS-Aware Duty Cycle MAC for Heterogeneous Traffic in Wireless Sensor Networks

PubMed Central

Monowar, Muhammad Mostafa; Rahman, Md. Obaidur; Hong, Choong Seon; Lee, Sungwon

2010-01-01

Energy conservation is one of the striking research issues now-a-days for power constrained wireless sensor networks (WSNs) and hence, several duty-cycle based MAC protocols have been devised for WSNs in the last few years. However, assimilation of diverse applications with different QoS requirements (i.e., delay and reliability) within the same network also necessitates in devising a generic duty-cycle based MAC protocol that can achieve both the delay and reliability guarantee, termed as multi-constrained QoS, while preserving the energy efficiency. To address this, in this paper, we propose a Multi-constrained QoS-aware duty-cycle MAC for heterogeneous traffic in WSNs (MQ-MAC). MQ-MAC classifies the traffic based on their multi-constrained QoS demands. Through extensive simulation using ns-2 we evaluate the performance of MQ-MAC. MQ-MAC provides the desired delay and reliability guarantee according to the nature of the traffic classes as well as achieves energy efficiency. PMID:22163439

Musculoskeletal Simulation Model Generation from MRI Data Sets and Motion Capture Data

NASA Astrophysics Data System (ADS)

Schmid, Jérôme; Sandholm, Anders; Chung, François; Thalmann, Daniel; Delingette, Hervé; Magnenat-Thalmann, Nadia

Today computer models and computer simulations of the musculoskeletal system are widely used to study the mechanisms behind human gait and its disorders. The common way of creating musculoskeletal models is to use a generic musculoskeletal model based on data derived from anatomical and biomechanical studies of cadaverous specimens. To adapt this generic model to a specific subject, the usual approach is to scale it. This scaling has been reported to introduce several errors because it does not always account for subject-specific anatomical differences. As a result, a novel semi-automatic workflow is proposed that creates subject-specific musculoskeletal models from magnetic resonance imaging (MRI) data sets and motion capture data. Based on subject-specific medical data and a model-based automatic segmentation approach, an accurate modeling of the anatomy can be produced while avoiding the scaling operation. This anatomical model coupled with motion capture data, joint kinematics information, and muscle-tendon actuators is finally used to create a subject-specific musculoskeletal model.

On generic obstructions to recovering correct statistics from climate simulations: Homogenization for deterministic maps and multiplicative noise

NASA Astrophysics Data System (ADS)

Gottwald, Georg; Melbourne, Ian

2013-04-01

Whereas diffusion limits of stochastic multi-scale systems have a long and successful history, the case of constructing stochastic parametrizations of chaotic deterministic systems has been much less studied. We present rigorous results of convergence of a chaotic slow-fast system to a stochastic differential equation with multiplicative noise. Furthermore we present rigorous results for chaotic slow-fast maps, occurring as numerical discretizations of continuous time systems. This raises the issue of how to interpret certain stochastic integrals; surprisingly the resulting integrals of the stochastic limit system are generically neither of Stratonovich nor of Ito type in the case of maps. It is shown that the limit system of a numerical discretisation is different to the associated continuous time system. This has important consequences when interpreting the statistics of long time simulations of multi-scale systems - they may be very different to the one of the original continuous time system which we set out to study.

[Access to drugs and the situation of the pharmaceutical market in Ecuador].

PubMed

Ortiz-Prado, Esteban; Galarza, Claudio; León, Fernando Cornejo; Ponce, Jorge

2014-07-01

In the area of public health, it is fundamental to understand the structure and dynamics of the Ecuadorian pharmaceutical market, its segmentation between the public and private sectors, and its relationship with supply and demand, both for generic and brand-name drugs. To achieve this, an observational descriptive study was conducted with information obtained from the available scientific, institutional, technical-administrative, and economic databases. Furthermore, the scientific information concerning the Ecuadorian and regional pharmaceutical market was reviewed through the PubMed and Ovid search engines. In Ecuador, 69.6% of dispensed drugs are brand-name and 30.4% are generics. Of all registered drugs in the country, 1,829 (13.6%) are considered over-the-counter and 11,622 (86.4%) are for sale under medical prescription. In terms of sales, 93.15% correspond to brand-name drugs and only 6.85% to generics. Ninety percent of the pharmacies are located in urban areas and only 10% in rural areas. In the last five years, prices have increased by 12.5% for brand-name drugs and 0.86% for generics. Brand-name drugs are dispensed and consumed 2.3 times more than generics. The majority of pharmacies are located in urban areas, showing that there is a relationship between purchasing power and access to drugs. Although the regulatory authority stipulates that 13% of drugs should be over-the-counter, approximately 60% of the population acquires drugs without a medical prescription.

Simulation of heating by optical absorption in nanoparticle dispersions (Conference Presentation)

NASA Astrophysics Data System (ADS)

Olbricht, Benjamin C.

2017-02-01

With the proliferation of highly confined, nanophotonic waveguides and laser sources with increasing intensity, the effects of laser heating will begin to greatly impact the materials used in optical applications. In order to better understand the mechanism of laser heating, its timescales, and the dispersion of heat into the material, simulations of nanoparticles in various media are presented. A generic model to describe a variety of nanoparticle shapes and sizes is desirable to describe complex phenomenon. These particles are dispersed into various solids, liquids, or gases depending on the application. To simulate nanoparticles and their interaction with their host material, the Finite Element Method (FEM) is used. Heat transfer following an absorption event is also described by a parabolic partial differential equation, and transient solutions are generated in response to continuous, pulsed, or modulated laser radiation. The simplest physical system described by FEM is that of a broadly-absorbing round-shaped nanoparticle dispersed in viscous host fluid or solid. Many experimental and theoretical studies conveniently describe a very similar system: a carbon "black" nanoparticle suspended in water. This material is well-known to exhibit nonlinear behavior when a laser pulse carrying 0.7 J/cm2 is incident on the material. For this process the FEM simulations agree with experimental results to show that a pulse of this fluence is capable of heating the solvent elements adjacent to the nanoparticle to their boiling point. This creates nonlinear scattering which is empirically observed as a nonlinear decrease in the transmitted power at this input fluence.

77 FR 70780 - Agency Forms Undergoing Paperwork Reduction Act Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-27

... requirements or power calculations that justify the proposed sample size, the expected response rate, methods... notice. Proposed Project Generic Clearance for the Collection of Qualitative Feedback on Agency Service... Collection of Qualitative Feedback on Agency Service Delivery'' to OMB for approval under the Paperwork...

How Knowledge Powers Reading

ERIC Educational Resources Information Center

Lemov, Doug

2017-01-01

Recent research shows that reading comprehension relies heavily on prior knowledge. Far more than generic "reading skills" like drawing inferences, making predictions, and knowing the function of subheads, how well students learn from a nonfiction text depends on their background knowledge of the text's subject matter. And in a cyclical…

Observational constraints on varying neutrino-mass cosmology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geng, Chao-Qiang; Lee, Chung-Chi; Myrzakulov, R.

We consider generic models of quintessence and we investigate the influence of massive neutrino matter with field-dependent masses on the matter power spectrum. In case of minimally coupled neutrino matter, we examine the effect in tracker models with inverse power-law and double exponential potentials. We present detailed investigations for the scaling field with a steep exponential potential, non-minimally coupled to massive neutrino matter, and we derive constraints on field-dependent neutrino masses from the observational data.

A simulation study of the flight dynamics of elastic aircraft. Volume 2: Data

NASA Technical Reports Server (NTRS)

Waszak, Martin R.; Davidson, John B.; Schmidt, David K.

1987-01-01

The simulation experiment described addresses the effects of structural flexibility on the dynamic characteristics of a generic family of aircraft. The simulation was performed using the NASA Langley VMS simulation facility. The vehicle models were obtained as part of this research project. The simulation results include complete response data and subjective pilot ratings and comments and so allow a variety of analyses. The subjective ratings and analysis of the time histories indicate that increased flexibility can lead to increased tracking errors, degraded handling qualities, and changes in the frequency content of the pilot inputs. These results, furthermore, are significantly affected by the visual cues available to the pilot.

An Open Simulation System Model for Scientific Applications

NASA Technical Reports Server (NTRS)

Williams, Anthony D.

1995-01-01

A model for a generic and open environment for running multi-code or multi-application simulations - called the open Simulation System Model (OSSM) - is proposed and defined. This model attempts to meet the requirements of complex systems like the Numerical Propulsion Simulator System (NPSS). OSSM places no restrictions on the types of applications that can be integrated at any state of its evolution. This includes applications of different disciplines, fidelities, etc. An implementation strategy is proposed that starts with a basic prototype, and evolves over time to accommodate an increasing number of applications. Potential (standard) software is also identified which may aid in the design and implementation of the system.

Development of a task-level robot programming and simulation system

NASA Technical Reports Server (NTRS)

Liu, H.; Kawamura, K.; Narayanan, S.; Zhang, G.; Franke, H.; Ozkan, M.; Arima, H.; Liu, H.

1987-01-01

An ongoing project in developing a Task-Level Robot Programming and Simulation System (TARPS) is discussed. The objective of this approach is to design a generic TARPS that can be used in a variety of applications. Many robotic applications require off-line programming, and a TARPS is very useful in such applications. Task level programming is object centered in that the user specifies tasks to be performed instead of robot paths. Graphics simulation provides greater flexibility and also avoids costly machine setup and possible damage. A TARPS has three major modules: world model, task planner and task simulator. The system architecture, design issues and some preliminary results are given.

The Personal Motion Platform

NASA Technical Reports Server (NTRS)

Park, Brian Vandellyn

1993-01-01

The Neutral Body Posture experienced in microgravity creates a biomechanical equilibrium by enabling the internal forces within the body to find their own balance. A patented reclining chair based on this posture provides a minimal stress environment for interfacing with computer systems for extended periods. When the chair is mounted on a 3 or 6 axis motion platform, a generic motion simulator for simulated digital environments is created. The Personal Motion Platform provides motional feedback to the occupant in synchronization with their movements inside the digital world which enhances the simulation experience. Existing HMD based simulation systems can be integrated to the turnkey system. Future developments are discussed.

SEL Ada reuse analysis and representations

NASA Technical Reports Server (NTRS)

Kester, Rush

1990-01-01

Overall, it was revealed that the pattern of Ada reuse has evolved from initial reuse of utility components into reuse of generalized application architectures. Utility components were both domain-independent utilities, such as queues and stacks, and domain-specific utilities, such as those that implement spacecraft orbit and attitude mathematical functions and physics or astronomical models. The level of reuse was significantly increased with the development of a generalized telemetry simulator architecture. The use of Ada generics significantly increased the level of verbatum reuse, which is due to the ability, using Ada generics, to parameterize the aspects of design that are configurable during reuse. A key factor in implementing generalized architectures was the ability to use generic subprogram parameters to tailor parts of the algorithm embedded within the architecture. The use of object oriented design (in which objects model real world entities) significantly improved the modularity for reuse. Encapsulating into packages the data and operations associated with common real world entities creates natural building blocks for reuse.

Generic Airspace Concepts and Research

NASA Technical Reports Server (NTRS)

Mogford, Richard H.

2010-01-01

The purpose of this study was to evaluate methods for reducing the training and memorization required to manage air traffic in mid-term, Next Generation Air Transportation System (NextGen) airspace. We contrasted the performance of controllers using a sector information display and NextGen automation tools while working with familiar and unfamiliar sectors. The airspace included five sectors from Oakland and Salt Lake City Centers configured as a "generic center" called "West High Center." The Controller Information Tool was used to present essential information for managing these sectors. The Multi Aircraft Control System air traffic control simulator provided data link and conflict detection and resolution. There were five experienced air traffic controller participants. Each was familiar with one or two of the five sectors, but not the others. The participants rotated through all five sectors during the ten data collection runs. The results addressing workload, traffic management, and safety, as well as controller and observer comments, supported the generic sector concept. The unfamiliar sectors were comparable to the familiar sectors on all relevant measures.

Genericness of inflation in isotropic loop quantum cosmology.

PubMed

Date, Ghanashyam; Hossain, Golam Mortuza

2005-01-14

Nonperturbative corrections from loop quantum cosmology (LQC) to the scalar matter sector are already known to imply inflation. We prove that the LQC modified scalar field generates exponential inflation in the small scale factor regime, for all positive definite potentials, independent of initial conditions and independent of ambiguity parameters. For positive semidefinite potentials it is always possible to choose, without fine-tuning, a value of one of the ambiguity parameters such that exponential inflation results, provided zeros of the potential are approached at most as a power law in the scale factor. In conjunction with the generic occurrence of bounce at small volumes, particle horizon is absent, thus eliminating the horizon problem of the standard big bang model.

Solution processed deposition of electron transport layers on perovskite crystal surface-A modeling based study

NASA Astrophysics Data System (ADS)

Mortuza, S. M.; Taufique, M. F. N.; Banerjee, Soumik

2017-02-01

The power conversion efficiency (PCE) of planar perovskite solar cells (PSCs) has reached up to ∼20%. However, structural and chemicals defects that lead to hysteresis in the perovskite based thin film pose challenges. Recent work has shown that thin films of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) deposited on the photo absorption layer, using solution processing techniques, minimize surface pin holes and defects thereby increasing the PCE. We developed and employed a multiscale model based on molecular dynamics (MD) and kinetic Monte Carlo (kMC) to establish a relationship between deposition rate and surface coverage on perovskite surface. The MD simulations of PCBMs dispersed in chlorobenzene, sandwiched between (110) perovskite substrates, indicate that PCBMs are deposited through anchoring of the oxygen atom of carbonyl group to the exposed lead (Pb) atom of (110) perovskite surface. Based on rates of distinct deposition events calculated from MD, kMC simulations were run to determine surface coverage at much larger time and length scales than accessible by MD alone. Based on the model, a generic relationship is established between deposition rate of PCBMs and surface coverage on perovskite crystal. The study also provides detailed insights into the morphology of the deposited film.

Scalable and Power Efficient Data Analytics for Hybrid Exascale Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choudhary, Alok; Samatova, Nagiza; Wu, Kesheng

This project developed a generic and optimized set of core data analytics functions. These functions organically consolidate a broad constellation of high performance analytical pipelines. As the architectures of emerging HPC systems become inherently heterogeneous, there is a need to design algorithms for data analysis kernels accelerated on hybrid multi-node, multi-core HPC architectures comprised of a mix of CPUs, GPUs, and SSDs. Furthermore, the power-aware trend drives the advances in our performance-energy tradeoff analysis framework which enables our data analysis kernels algorithms and software to be parameterized so that users can choose the right power-performance optimizations.

Generic Kalman Filter Software

NASA Technical Reports Server (NTRS)

Lisano, Michael E., II; Crues, Edwin Z.

2005-01-01

The Generic Kalman Filter (GKF) software provides a standard basis for the development of application-specific Kalman-filter programs. Historically, Kalman filters have been implemented by customized programs that must be written, coded, and debugged anew for each unique application, then tested and tuned with simulated or actual measurement data. Total development times for typical Kalman-filter application programs have ranged from months to weeks. The GKF software can simplify the development process and reduce the development time by eliminating the need to re-create the fundamental implementation of the Kalman filter for each new application. The GKF software is written in the ANSI C programming language. It contains a generic Kalman-filter-development directory that, in turn, contains a code for a generic Kalman filter function; more specifically, it contains a generically designed and generically coded implementation of linear, linearized, and extended Kalman filtering algorithms, including algorithms for state- and covariance-update and -propagation functions. The mathematical theory that underlies the algorithms is well known and has been reported extensively in the open technical literature. Also contained in the directory are a header file that defines generic Kalman-filter data structures and prototype functions and template versions of application-specific subfunction and calling navigation/estimation routine code and headers. Once the user has provided a calling routine and the required application-specific subfunctions, the application-specific Kalman-filter software can be compiled and executed immediately. During execution, the generic Kalman-filter function is called from a higher-level navigation or estimation routine that preprocesses measurement data and post-processes output data. The generic Kalman-filter function uses the aforementioned data structures and five implementation- specific subfunctions, which have been developed by the user on the basis of the aforementioned templates. The GKF software can be used to develop many different types of unfactorized Kalman filters. A developer can choose to implement either a linearized or an extended Kalman filter algorithm, without having to modify the GKF software. Control dynamics can be taken into account or neglected in the filter-dynamics model. Filter programs developed by use of the GKF software can be made to propagate equations of motion for linear or nonlinear dynamical systems that are deterministic or stochastic. In addition, filter programs can be made to operate in user-selectable "covariance analysis" and "propagation-only" modes that are useful in design and development stages.

Effects of Antenna Beam Chromaticity on Redshifted 21 cm Power Spectrum and Implications for Hydrogen Epoch of Reionization Array

NASA Astrophysics Data System (ADS)

Thyagarajan, Nithyanandan; Parsons, Aaron R.; DeBoer, David R.; Bowman, Judd D.; Ewall-Wice, Aaron M.; Neben, Abraham R.; Patra, Nipanjana

2016-07-01

Unaccounted for systematics from foregrounds and instruments can severely limit the sensitivity of current experiments from detecting redshifted 21 cm signals from the Epoch of Reionization (EoR). Upcoming experiments are faced with a challenge to deliver more collecting area per antenna element without degrading the data with systematics. This paper and its companions show that dishes are viable for achieving this balance using the Hydrogen Epoch of Reionization Array (HERA) as an example. Here, we specifically identify spectral systematics associated with the antenna power pattern as a significant detriment to all EoR experiments which causes the already bright foreground power to leak well beyond ideal limits and contaminate the otherwise clean EoR signal modes. A primary source of this chromaticity is reflections in the antenna-feed assembly and between structures in neighboring antennas. Using precise foreground simulations taking wide-field effects into account, we provide a generic framework to set cosmologically motivated design specifications on these reflections to prevent further EoR signal degradation. We show that HERA will not be impeded by such spectral systematics and demonstrate that even in a conservative scenario that does not perform removal of foregrounds, HERA will detect the EoR signal in line-of-sight k-modes, {k}\\parallel ≳ 0.2 h Mpc-1, with high significance. Under these conditions, all baselines in a 19-element HERA layout are capable of detecting EoR over a substantial observing window on the sky.

CMB temperature bispectrum induced by cosmic strings

NASA Astrophysics Data System (ADS)

Hindmarsh, Mark; Ringeval, Christophe; Suyama, Teruaki

2009-10-01

The cosmic microwave background (CMB) bispectrum of the temperature anisotropies induced by a network of cosmic strings is derived for small angular scales, under the assumption that the principal cause of temperature fluctuations is the Gott-Kaiser-Stebbins effect. We provide analytical expressions for all isosceles triangle configurations in Fourier space. Their overall amplitude is amplified as the inverse cube of the angle and diverges for flat triangles. The isosceles configurations generically lead to a negative bispectrum with a power-law decay ℓ-6 for large multipole ℓ. However, collapsed triangles are found to be associated with a positive bispectrum whereas the squeezed triangles still exhibit negative values. We then compare our analytical estimates to a direct computation of the bispectrum from a set of 300 statistically independent temperature maps obtained from Nambu-Goto cosmic string simulations in a Friedmann-Lemaître-Robertson-Walker universe. We find good agreement for the overall amplitude, the power-law behavior, and the angle dependency of the various triangle configurations. At ℓ˜500 the cosmic string Gott-Kaiser-Stebbins effect contributes approximately the same equilateral CMB bispectrum amplitude as an inflationary model with |fNLloc|≃103, if the strings contribute about 10% of the temperature power spectrum at ℓ=10. Current bounds on fNL are not derived using cosmic string bispectrum templates, and so our fNL estimate cannot be used to derive bounds on strings. However it does suggest that string bispectrum templates should be included in the search of CMB non-Gaussianities.

77 FR 63798 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

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Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... requirements or power calculations that justify the proposed sample size, the expected response rate, methods... Qualitative Feedback on Agency Service Delivery April 22, 2011. AGENCY: Department of Agriculture (USDA... Qualitative Feedback on Agency Service Delivery'' to OMB for approval under the Paperwork Reduction Act (PRA...

76 FR 10939 - Agency Information Collection Activities: Proposed Collection; Comment Request; Generic Clearance...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-28

... requirements or power calculations that justify the proposed sample size, the expected response rate, methods... of Qualitative Feedback on Agency Service Delivery AGENCY: Federal Railroad Administration (FRA... Qualitative Feedback on Agency Service Delivery'' to OMB for approval under the Paperwork Reduction Act (PRA...

Towards Evolutional Authoring Support Systems

ERIC Educational Resources Information Center

Aroyo, Lora; Mizoguchi, Riichiro

2004-01-01

The ultimate aim of this research is to specify and implement a general authoring framework for content and knowledge engineering for Intelligent Educational Systems (IES). In this context we attempt to develop an authoring tool supporting this framework that is powerful in its functionality, generic in its support of instructional strategies and…

Modeling integrated biomass gasification business concepts

Treesearch

Peter J. Ince; Ted Bilek; Mark A. Dietenberger

2011-01-01

Biomass gasification is an approach to producing energy and/or biofuels that could be integrated into existing forest product production facilities, particularly at pulp mills. Existing process heat and power loads tend to favor integration at existing pulp mills. This paper describes a generic modeling system for evaluating integrated biomass gasification business...

Information Services at the Nuclear Safety Analysis Center.

ERIC Educational Resources Information Center

Simard, Ronald

This paper describes the operations of the Nuclear Safety Analysis Center. Established soon after an accident at the Three Mile Island nuclear power plant near Harrisburg, Pennsylvania, its efforts were initially directed towards a detailed analysis of the accident. Continuing functions include: (1) the analysis of generic nuclear safety issues,…

Translating Learning into Numbers: A Generic Framework for Learning Analytics

ERIC Educational Resources Information Center

Greller, Wolfgang; Drachsler, Hendrik

2012-01-01

With the increase in available educational data, it is expected that Learning Analytics will become a powerful means to inform and support learners, teachers and their institutions in better understanding and predicting personal learning needs and performance. However, the processes and requirements behind the beneficial application of Learning…

A Study of Umbilical Communication Interface of Simulator Kernel to Enhance Visibility and Controllability

NASA Astrophysics Data System (ADS)

Koo, Cheol Hea; Lee, Hoon Hee; Moon, Sung Tae; Han, Sang Hyuck; Ju, Gwang Hyeok

2013-08-01

In aerospace research and practical development area, increasing the usage of simulation in software development, component design and system operation has been maintained and the increasing speed getting faster. This phenomenon can be found from the easiness of handling of simulation and the powerfulness of the output from the simulation. Simulation brings lots of benefit from the several characteristics of it as following, - easy to handle ; it is never broken or damaged by mistake - never wear out ; it is never getting old - cost effective ; once it is built, it can be distributed over 100 ~ 1000 people GenSim (Generic Simulator) which is developing by KARI and compatible with ESA SMP standard provides such a simulation platform to support flight software validation and mission operation verification. User interface of GenSim is shown in Figure 1 [1,2]. As shown in Figure 1, as most simulation platform typically has, GenSim has GRD (Graphical Display) and AND (Alpha Numeric Display). But frequently more complex and powerful handling of the simulated data is required at the actual system validation for example mission operation. In Figure 2, system simulation result of COMS (Communication, Ocean, and Meteorological Satellite, launched at June 28 2008) is being drawn by Celestia 3D program. In this case, the needed data from Celestia is given by one of the simulation model resident in system simulator through UDP network connection in this case. But the requirement of displaying format, data size, and communication rate is variable so developer has to manage the connection protocol manually at each time and each case. It brings a chaos in the simulation model design and development, also to the performance issue at last. Performance issue is happen when the required data magnitude is higher than the capacity of simulation kernel to process the required data safely. The problem is that the sending data to a visualization tool such as celestia is given by a simulation model not kernel. Because the simulation model has no way to know about the status of simulation kernel load to process simulation events, as the result the simulation model sends the data as frequent as needed. This story may make many potential problems like lack of response, failure of meeting deadline and data integrity problem with the model data during the simulation. SIMSAT and EuroSim gives a warning message if the user request event such as printing log can't be processed as planned or requested. As the consequence the requested event will be delayed or not be able to be processed, and it means that this phenomenon may violate the planned deadline. In most soft real time simulation, this can be neglected and just make a little inconvenience of users. But it shall be noted that if the user request is not managed properly at some critical situation, the simulation results may be ended with a mess and chaos. As we traced the disadvantages of what simulation model provide the user request, simulation model is not appropriate to provide a service for such user request. This kind of work shall be minimized as much as possible.

Least Squares Approach to the Alignment of the Generic High Precision Tracking System

NASA Astrophysics Data System (ADS)

de Renstrom, Pawel Brückman; Haywood, Stephen

2006-04-01

A least squares method to solve a generic alignment problem of a high granularity tracking system is presented. The algorithm is based on an analytical linear expansion and allows for multiple nested fits, e.g. imposing a common vertex for groups of particle tracks is of particular interest. We present a consistent and complete recipe to impose constraints on either implicit or explicit parameters. The method has been applied to the full simulation of a subset of the ATLAS silicon tracking system. The ultimate goal is to determine ≈35,000 degrees of freedom (DoF's). We present a limited scale exercise exploring various aspects of the solution.

Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients

NASA Astrophysics Data System (ADS)

Novikova, Elizaveta A.; Raab, Matthew; Discher, Dennis E.; Storm, Cornelis

2017-02-01

Cells move differently on substrates with different rigidities: the persistence time of their motion is higher on stiffer substrates. We show that this behavior—in and of itself—results in a net flux of cells directed up a soft-to-stiff gradient. Using simple random walk models with varying persistence and stochastic simulations, we characterize the propensity to move in terms of the durotactic index also measured in experiments. A one-dimensional model captures the essential features and highlights the competition between diffusive spreading and linear, wavelike propagation. Persistence-driven durokinesis is generic and may be of use in the design of instructive environments for cells and other motile, mechanosensitive objects.

Simple Emergent Power Spectra from Complex Inflationary Physics

NASA Astrophysics Data System (ADS)

Dias, Mafalda; Frazer, Jonathan; Marsh, M. C. David

2016-09-01

We construct ensembles of random scalar potentials for Nf-interacting scalar fields using nonequilibrium random matrix theory, and use these to study the generation of observables during small-field inflation. For Nf=O (few ), these heavily featured scalar potentials give rise to power spectra that are highly nonlinear, at odds with observations. For Nf≫1 , the superhorizon evolution of the perturbations is generically substantial, yet the power spectra simplify considerably and become more predictive, with most realizations being well approximated by a linear power spectrum. This provides proof of principle that complex inflationary physics can give rise to simple emergent power spectra. We explain how these results can be understood in terms of large Nf universality of random matrix theory.

Simple Emergent Power Spectra from Complex Inflationary Physics.

PubMed

Dias, Mafalda; Frazer, Jonathan; Marsh, M C David

2016-09-30

We construct ensembles of random scalar potentials for N_{f}-interacting scalar fields using nonequilibrium random matrix theory, and use these to study the generation of observables during small-field inflation. For N_{f}=O(few), these heavily featured scalar potentials give rise to power spectra that are highly nonlinear, at odds with observations. For N_{f}≫1, the superhorizon evolution of the perturbations is generically substantial, yet the power spectra simplify considerably and become more predictive, with most realizations being well approximated by a linear power spectrum. This provides proof of principle that complex inflationary physics can give rise to simple emergent power spectra. We explain how these results can be understood in terms of large N_{f} universality of random matrix theory.

Knowledge and abilities catalog for nuclear power plant operators: Boiling water reactors, Revision 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-08-01

The Knowledge and Abilities Catalog for Nuclear Power Plant Operators: Boiling-Water Reactors (BWRs) (NUREG-1123, Revision 1) provides the basis for the development of content-valid licensing examinations for reactor operators (ROs) and senior reactor operators (SROs). The examinations developed using the BWR Catalog along with the Operator Licensing Examiner Standards (NUREG-1021) and the Examiner`s Handbook for Developing Operator Licensing Written Examinations (NUREG/BR-0122), will cover the topics listed under Title 10, Code of Federal Regulations, Part 55 (10 CFR 55). The BWR Catalog contains approximately 7,000 knowledge and ability (K/A) statements for ROs and SROs at BWRs. The catalog is organized intomore » six major sections: Organization of the Catalog, Generic Knowledge and Ability Statements, Plant Systems grouped by Safety Functions, Emergency and Abnormal Plant Evolutions, Components, and Theory. Revision 1 to the BWR Catalog represents a modification in form and content of the original catalog. The K/As were linked to their applicable 10 CFR 55 item numbers. SRO level K/As were identified by 10 CFR 55.43 item numbers. The plant-wide generic and system generic K/As were combined in one section with approximately one hundred new K/As. Component Cooling Water and Instrument Air Systems were added to the Systems Section. Finally, High Containment Hydrogen Concentration and Plant Fire On Site evolutions added to the Emergency and Abnormal Plant Evolutions section.« less

MODELS OF KILONOVA/MACRONOVA EMISSION FROM BLACK HOLE–NEUTRON STAR MERGERS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawaguchi, Kyohei; Shibata, Masaru; Kyutoku, Koutarou

2016-07-01

Black hole–neutron star (BH–NS) mergers are among the most promising gravitational-wave sources for ground-based detectors, and gravitational waves from BH–NS mergers are expected to be detected in the next few years. The simultaneous detection of electromagnetic counterparts with gravitational waves would provide rich information about merger events. Among the possible electromagnetic counterparts from BH–NS mergers is the so-called kilonova/macronova, emission powered by the decay of radioactive r-process nuclei, which is one of the best targets for follow-up observations. We derive fitting formulas for the mass and the velocity of ejecta from a generic BH–NS merger based on recently performed numerical-relativitymore » simulations. We combine these fitting formulas with a new semi-analytic model for a BH–NS kilonova/macronova lightcurve, which reproduces the results of radiation-transfer simulations. Specifically, the semi-analytic model reproduces the results of each band magnitude obtained by the previous radiation-transfer simulations within ∼1 mag. By using this semi-analytic model we found that, at 400 Mpc, the kilonova/macronova is as bright as 22–24 mag for cases with a small chirp mass and a high black hole spin, and >28 mag for a large chirp mass and a low black hole spin. We also apply our model to GRB 130603B as an illustration, and show that a BH–NS merger with a rapidly spinning black hole and a large neutron star radius is favored.« less

Shape optimization of electrostatically driven microcantilevers using simulated annealing to enhance static travel range

NASA Astrophysics Data System (ADS)

Trivedi, R. R.; Joglekar, M. M.; Shimpi, R. P.; Pawaskar, D. N.

2013-12-01

The objective of this paper is to present a systematic development of the generic shape optimization of elec- trostatically actuated microcantilever beams for extending their static travel range. Electrostatic actuators are widely used in micro electro mechanical system (MEMS) devices because of low power density and ease of fab- rication. However, their useful travel range is often restricted by a phenomenon known as pull-in instability. The Rayleigh- Ritz energy method is used for computation of pull-in parameters which includes electrostatic potential and fringing field effect. Appropriate width function and linear thickness functions are employed along the length of the non-prismatic beam to achieve enhanced travel range. Parameters used for varying the thick- ness and width functions are optimized using simulated annealing with pattern search method towards the end to refine the results. Appropriate penalties are imposed on the violation of volume, width, thickness and area constraints. Nine test cases are considered for demonstration of the said optimization method. Our results indicate that around 26% increase in the travel range of a non-prismatic beam can be achieved after optimiza- tion compared to that in a prismatic beam having the same volume. Our results also show an improvement in the pull-in displacement of around 5% compared to that of a variable width constant thickness actuator. We show that simulated annealing is an effective and flexible method to carry out design optimization of structural elements under electrostatic loading.

A Generic Modeling Process to Support Functional Fault Model Development

NASA Technical Reports Server (NTRS)

Maul, William A.; Hemminger, Joseph A.; Oostdyk, Rebecca; Bis, Rachael A.

2016-01-01

Functional fault models (FFMs) are qualitative representations of a system's failure space that are used to provide a diagnostic of the modeled system. An FFM simulates the failure effect propagation paths within a system between failure modes and observation points. These models contain a significant amount of information about the system including the design, operation and off nominal behavior. The development and verification of the models can be costly in both time and resources. In addition, models depicting similar components can be distinct, both in appearance and function, when created individually, because there are numerous ways of representing the failure space within each component. Generic application of FFMs has the advantages of software code reuse: reduction of time and resources in both development and verification, and a standard set of component models from which future system models can be generated with common appearance and diagnostic performance. This paper outlines the motivation to develop a generic modeling process for FFMs at the component level and the effort to implement that process through modeling conventions and a software tool. The implementation of this generic modeling process within a fault isolation demonstration for NASA's Advanced Ground System Maintenance (AGSM) Integrated Health Management (IHM) project is presented and the impact discussed.

Geometric analysis characterizes molecular rigidity in generic and non-generic protein configurations

PubMed Central

Budday, Dominik; Leyendecker, Sigrid; van den Bedem, Henry

2015-01-01

Proteins operate and interact with partners by dynamically exchanging between functional substates of a conformational ensemble on a rugged free energy landscape. Understanding how these substates are linked by coordinated, collective motions requires exploring a high-dimensional space, which remains a tremendous challenge. While molecular dynamics simulations can provide atomically detailed insight into the dynamics, computational demands to adequately sample conformational ensembles of large biomolecules and their complexes often require tremendous resources. Kinematic models can provide high-level insights into conformational ensembles and molecular rigidity beyond the reach of molecular dynamics by reducing the dimensionality of the search space. Here, we model a protein as a kinematic linkage and present a new geometric method to characterize molecular rigidity from the constraint manifold Q and its tangent space Q at the current configuration q. In contrast to methods based on combinatorial constraint counting, our method is valid for both generic and non-generic, e.g., singular configurations. Importantly, our geometric approach provides an explicit basis for collective motions along floppy modes, resulting in an efficient procedure to probe conformational space. An atomically detailed structural characterization of coordinated, collective motions would allow us to engineer or allosterically modulate biomolecules by selectively stabilizing conformations that enhance or inhibit function with broad implications for human health. PMID:26213417

Geometric analysis characterizes molecular rigidity in generic and non-generic protein configurations

NASA Astrophysics Data System (ADS)

Budday, Dominik; Leyendecker, Sigrid; van den Bedem, Henry

2015-10-01

Proteins operate and interact with partners by dynamically exchanging between functional substates of a conformational ensemble on a rugged free energy landscape. Understanding how these substates are linked by coordinated, collective motions requires exploring a high-dimensional space, which remains a tremendous challenge. While molecular dynamics simulations can provide atomically detailed insight into the dynamics, computational demands to adequately sample conformational ensembles of large biomolecules and their complexes often require tremendous resources. Kinematic models can provide high-level insights into conformational ensembles and molecular rigidity beyond the reach of molecular dynamics by reducing the dimensionality of the search space. Here, we model a protein as a kinematic linkage and present a new geometric method to characterize molecular rigidity from the constraint manifold Q and its tangent space Tq Q at the current configuration q. In contrast to methods based on combinatorial constraint counting, our method is valid for both generic and non-generic, e.g., singular configurations. Importantly, our geometric approach provides an explicit basis for collective motions along floppy modes, resulting in an efficient procedure to probe conformational space. An atomically detailed structural characterization of coordinated, collective motions would allow us to engineer or allosterically modulate biomolecules by selectively stabilizing conformations that enhance or inhibit function with broad implications for human health.

Hydrodynamic suppression of phase separation in active suspensions.

PubMed

Matas-Navarro, Ricard; Golestanian, Ramin; Liverpool, Tanniemola B; Fielding, Suzanne M

2014-09-01

We simulate with hydrodynamics a suspension of active disks squirming through a Newtonian fluid. We explore numerically the full range of squirmer area fractions from dilute to close packed and show that "motility induced phase separation," which was recently proposed to arise generically in active matter, and which has been seen in simulations of active Brownian disks, is strongly suppressed by hydrodynamic interactions. We give an argument for why this should be the case and support it with counterpart simulations of active Brownian disks in a parameter regime that provides a closer counterpart to hydrodynamic suspensions than in previous studies.

Research on an expert system for database operation of simulation-emulation math models. Volume 1, Phase 1: Results

NASA Technical Reports Server (NTRS)

Kawamura, K.; Beale, G. O.; Schaffer, J. D.; Hsieh, B. J.; Padalkar, S.; Rodriguez-Moscoso, J. J.

1985-01-01

The results of the first phase of Research on an Expert System for Database Operation of Simulation/Emulation Math Models, is described. Techniques from artificial intelligence (AI) were to bear on task domains of interest to NASA Marshall Space Flight Center. One such domain is simulation of spacecraft attitude control systems. Two related software systems were developed to and delivered to NASA. One was a generic simulation model for spacecraft attitude control, written in FORTRAN. The second was an expert system which understands the usage of a class of spacecraft attitude control simulation software and can assist the user in running the software. This NASA Expert Simulation System (NESS), written in LISP, contains general knowledge about digital simulation, specific knowledge about the simulation software, and self knowledge.

Pilot-in-the-Loop CFD Method Development

DTIC Science & Technology

2014-06-16

CFD analysis. Coupled simulations will be run at PSU on the COCOA -4 cluster, a high performance computing cluster. The CRUNCH CFD software has...been installed on the COCOA -4 servers and initial software tests are being conducted. Initial efforts will use the Generic Frigate Shape SFS-2 to

Recommendations for placement of cable median barriers on 6:1 and 4:1 sloped medians with horizontal curvatures.

DOT National Transportation Integrated Search

2012-09-01

This report summarizes the research efforts of using finite element modeling and simulations to evaluate the performance of generic lowtension : cable median barriers (CMBs) on four-lane and six-lane freeways with a 46-foot median, horizontal curvatu...

GOST: A generic ordinal sequential trial design for a treatment trial in an emerging pandemic.

PubMed

Whitehead, John; Horby, Peter

2017-03-01

Conducting clinical trials to assess experimental treatments for potentially pandemic infectious diseases is challenging. Since many outbreaks of infectious diseases last only six to eight weeks, there is a need for trial designs that can be implemented rapidly in the face of uncertainty. Outbreaks are sudden and unpredictable and so it is essential that as much planning as possible takes place in advance. Statistical aspects of such trial designs should be evaluated and discussed in readiness for implementation. This paper proposes a generic ordinal sequential trial design (GOST) for a randomised clinical trial comparing an experimental treatment for an emerging infectious disease with standard care. The design is intended as an off-the-shelf, ready-to-use robust and flexible option. The primary endpoint is a categorisation of patient outcome according to an ordinal scale. A sequential approach is adopted, stopping as soon as it is clear that the experimental treatment has an advantage or that sufficient advantage is unlikely to be detected. The properties of the design are evaluated using large-sample theory and verified for moderate sized samples using simulation. The trial is powered to detect a generic clinically relevant difference: namely an odds ratio of 2 for better rather than worse outcomes. Total sample sizes (across both treatments) of between 150 and 300 patients prove to be adequate in many cases, but the precise value depends on both the magnitude of the treatment advantage and the nature of the ordinal scale. An advantage of the approach is that any erroneous assumptions made at the design stage about the proportion of patients falling into each outcome category have little effect on the error probabilities of the study, although they can lead to inaccurate forecasts of sample size. It is important and feasible to pre-determine many of the statistical aspects of an efficient trial design in advance of a disease outbreak. The design can then be tailored to the specific disease under study once its nature is better understood.

A Coordinated Initialization Process for the Distributed Space Exploration Simulation (DSES)

NASA Technical Reports Server (NTRS)

Phillips, Robert; Dexter, Dan; Hasan, David; Crues, Edwin Z.

2007-01-01

This document describes the federate initialization process that was developed at the NASA Johnson Space Center with the HIIA Transfer Vehicle Flight Controller Trainer (HTV FCT) simulations and refined in the Distributed Space Exploration Simulation (DSES). These simulations use the High Level Architecture (HLA) IEEE 1516 to provide the communication and coordination between the distributed parts of the simulation. The purpose of the paper is to describe a generic initialization sequence that can be used to create a federate that can: 1. Properly initialize all HLA objects, object instances, interactions, and time management 2. Check for the presence of all federates 3. Coordinate startup with other federates 4. Robustly initialize and share initial object instance data with other federates.

Code Samples Used for Complexity and Control

NASA Astrophysics Data System (ADS)

Ivancevic, Vladimir G.; Reid, Darryn J.

2015-11-01

The following sections are included: * MathematicaⓇ Code * Generic Chaotic Simulator * Vector Differential Operators * NLS Explorer * 2C++ Code * C++ Lambda Functions for Real Calculus * Accelerometer Data Processor * Simple Predictor-Corrector Integrator * Solving the BVP with the Shooting Method * Linear Hyperbolic PDE Solver * Linear Elliptic PDE Solver * Method of Lines for a Set of the NLS Equations * C# Code * Iterative Equation Solver * Simulated Annealing: A Function Minimum * Simple Nonlinear Dynamics * Nonlinear Pendulum Simulator * Lagrangian Dynamics Simulator * Complex-Valued Crowd Attractor Dynamics * Freeform Fortran Code * Lorenz Attractor Simulator * Complex Lorenz Attractor * Simple SGE Soliton * Complex Signal Presentation * Gaussian Wave Packet * Hermitian Matrices * Euclidean L2-Norm * Vector/Matrix Operations * Plain C-Code: Levenberg-Marquardt Optimizer * Free Basic Code: 2D Crowd Dynamics with 3000 Agents

Thermodynamic and transport properties of nitrogen fluid: Molecular theory and computer simulations

NASA Astrophysics Data System (ADS)

Eskandari Nasrabad, A.; Laghaei, R.

2018-04-01

Computer simulations and various theories are applied to compute the thermodynamic and transport properties of nitrogen fluid. To model the nitrogen interaction, an existing potential in the literature is modified to obtain a close agreement between the simulation results and experimental data for the orthobaric densities. We use the Generic van der Waals theory to calculate the mean free volume and apply the results within the modified Cohen-Turnbull relation to obtain the self-diffusion coefficient. Compared to experimental data, excellent results are obtained via computer simulations for the orthobaric densities, the vapor pressure, the equation of state, and the shear viscosity. We analyze the results of the theory and computer simulations for the various thermophysical properties.

The development of an autonomous rendezvous and docking simulation using rapid integration and prototyping technology

NASA Technical Reports Server (NTRS)

Shackelford, John H.; Saugen, John D.; Wurst, Michael J.; Adler, James

1991-01-01

A generic planar 3 degree of freedom simulation was developed that supports hardware in the loop simulations, guidance and control analysis, and can directly generate flight software. This simulation was developed in a small amount of time utilizing rapid prototyping techniques. The approach taken to develop this simulation tool, the benefits seen using this approach to development, and on-going efforts to improve and extend this capability are described. The simulation is composed of 3 major elements: (1) Docker dynamics model, (2) Dockee dynamics model, and (3) Docker Control System. The docker and dockee models are based on simple planar orbital dynamics equations using a spherical earth gravity model. The docker control system is based on a phase plane approach to error correction.

Configuration Management File Manager Developed for Numerical Propulsion System Simulation

NASA Technical Reports Server (NTRS)

Follen, Gregory J.

1997-01-01

One of the objectives of the High Performance Computing and Communication Project's (HPCCP) Numerical Propulsion System Simulation (NPSS) is to provide a common and consistent way to manage applications, data, and engine simulations. The NPSS Configuration Management (CM) File Manager integrated with the Common Desktop Environment (CDE) window management system provides a common look and feel for the configuration management of data, applications, and engine simulations for U.S. engine companies. In addition, CM File Manager provides tools to manage a simulation. Features include managing input files, output files, textual notes, and any other material normally associated with simulation. The CM File Manager includes a generic configuration management Application Program Interface (API) that can be adapted for the configuration management repositories of any U.S. engine company.

Probabilistic load simulation: Code development status

NASA Astrophysics Data System (ADS)

Newell, J. F.; Ho, H.

1991-05-01

The objective of the Composite Load Spectra (CLS) project is to develop generic load models to simulate the composite load spectra that are included in space propulsion system components. The probabilistic loads thus generated are part of the probabilistic design analysis (PDA) of a space propulsion system that also includes probabilistic structural analyses, reliability, and risk evaluations. Probabilistic load simulation for space propulsion systems demands sophisticated probabilistic methodology and requires large amounts of load information and engineering data. The CLS approach is to implement a knowledge based system coupled with a probabilistic load simulation module. The knowledge base manages and furnishes load information and expertise and sets up the simulation runs. The load simulation module performs the numerical computation to generate the probabilistic loads with load information supplied from the CLS knowledge base.

NASA Tech Briefs, September 2005

NASA Technical Reports Server (NTRS)

2005-01-01

Topivs include: Diamond-Coated Carbon Nanotubes for Efficient Field Emission; Improved Anode Coatings for Direct Methanol Fuel Cells; Advanced Ablative Insulators and Methods of Making Them; PETIs as High-Temperature Resin-Transfer-Molding Materials; Stable Polyimides for Terrestrial and Space Uses; Low-Density, Aerogel-Filled Thermal-Insulation Tiles; High-Performance Polymers Having Low Melt Viscosities; Nonflammable, Hydrophobic Aerogel Composites for Insulation; Front-Side Microstrip Line Feeding a Raised Antenna Patch; Medium-Frequency Pseudonoise Georadar; Facilitating Navigation Through Large Archives; Program for Weibull Analysis of Fatigue Data; Comprehensive Micromechanics-Analysis Code - Version 4.0; Component-Based Visualization System; Software for Engineering Simulations of a Spacecraft; LabVIEW Interface for PCI-SpaceWire Interface Card; Path Following with Slip Compensation for a Mars Rover; International Space Station Electric Power System Performance Code-SPACE; Software for Automation of Real-Time Agents, Version 2; Software for Optimizing Plans Involving Interdependent Goals; Computing Gravitational Fields of Finite-Sized Bodies; Custom Sky-Image Mosaics from NASA's Information Power Grid; ANTLR Tree Grammar Generator and Extensions; Generic Kalman Filter Software; Alignment Stage for a Cryogenic Dilatometer; Rugged Iris Mechanism; Treatments To Produce Stabilized Aluminum Mirrors for Cryogenic Uses; Making AlNx Tunnel Barriers Using a Low-Energy Nitrogen-Ion Beam; Making Wide-IF SIS Mixers with Suspended Metal-Beam Leads; Sol-Gel Glass Holographic Light-Shaping Diffusers; Automated Counting of Particles To Quantify Cleanliness; Phase Correction for GPS Antenna with Nonunique Phase Center; Compact Infrasonic Windscreen; Broadband External-Cavity Diode Laser; High-Efficiency Solar Cells Using Photonic-Bandgap Materials; Generating Solid Models from Topographical Data; Computationally Lightweight Air-Traffic-Control Simulation; Spool Valve for Switching Air Flows Between Two Beds; Partial Model of Insulator/ Insulator Contact Charging; Asymmetric Electrostatic Radiation Shielding for Spacecraft; and Reusable Hybrid Propellant Modules for Outer-Space Transport.

The system integration and verification testing of an orbital maneuvering vehicle for an air bearing floor

NASA Technical Reports Server (NTRS)

Shields, N. L., Jr.; Martin, M. F.; Paulukaitis, K. R.; Haslam, J. W., Jr.; Henderson, D. E.

1986-01-01

The teleoperator and Robotics Evaluation Facility (TOREF) is composed of a 4,000 square foot precision air bearing floor, the Teleoperator Motion Base, the Target Motion and Support Simulator, the mock-ups of the Hubble Space Telescope, Multi-mission Modular Spacecraft, and the Orbital Maneuvering Vehicle (OMV). The TOREF and its general capabilities to support the OMV and other remote system simulations; the facility operating procedures and requirements; and the results of generic OMV investigations are summarized.

A Study of Airline Passenger Susceptibility to Atmospheric Turbulence Hazard

NASA Technical Reports Server (NTRS)

Stewart, Eric C.

2000-01-01

A simple, generic, simulation math model of a commercial airliner has been developed to study the susceptibility of unrestrained passengers to large, discrete gust encounters. The math model simulates the longitudinal motion to vertical gusts and includes (1) motion of an unrestrained passenger in the rear cabin, (2) fuselage flexibility, (3) the lag in the downwash from the wing to the tail, and (4) unsteady lift effects. Airplane and passenger response contours are calculated for a matrix of gust amplitudes and gust lengths of a simulated mountain rotor. A comparison of the model-predicted responses to data from three accidents indicates that the accelerations in actual accidents are sometimes much larger than the simulated gust encounters.

Development of a non-linear simulation for generic hypersonic vehicles - ASUHS1

NASA Technical Reports Server (NTRS)

Salas, Juan; Lovell, T. Alan; Schmidt, David K.

1993-01-01

A nonlinear simulation is developed to model the longitudinal motion of a vehicle in hypersonic flight. The equations of motion pertinent to this study are presented. Analytic expressions for the aerodynamic forces acting on a hypersonic vehicle which were obtained from Newtonian Impact Theory are further developed. The control surface forces are further examined to incorporate vehicle elastic motion. The purpose is to establish feasible equations of motion which combine rigid body, elastic, and aeropropulsive dynamics for use in nonlinear simulations. The software package SIMULINK is used to implement the simulation. Also discussed are issues needing additional attention and potential problems associated with the implementation (with proposed solutions).

Loading relativistic Maxwell distributions in particle simulations

NASA Astrophysics Data System (ADS)

Zenitani, S.

2015-12-01

In order to study energetic plasma phenomena by using particle-in-cell (PIC) and Monte-Carlo simulations, we need to deal with relativistic velocity distributions in these simulations. However, numerical algorithms to deal with relativistic distributions are not well known. In this contribution, we overview basic algorithms to load relativistic Maxwell distributions in PIC and Monte-Carlo simulations. For stationary relativistic Maxwellian, the inverse transform method and the Sobol algorithm are reviewed. To boost particles to obtain relativistic shifted-Maxwellian, two rejection methods are newly proposed in a physically transparent manner. Their acceptance efficiencies are 􏰅50% for generic cases and 100% for symmetric distributions. They can be combined with arbitrary base algorithms.

Electrolyzers Enhancing Flexibility in Electric Grids

DOE PAGES

Mohanpurkar, Manish; Luo, Yusheng; Terlip, Danny; ...

2017-11-10

This paper presents a real-time simulation with a hardware-in-the-loop (HIL)-based approach for verifying the performance of electrolyzer systems in providing grid support. Hydrogen refueling stations may use electrolyzer systems to generate hydrogen and are proposed to have the potential of becoming smarter loads that can proactively provide grid services. On the basis of experimental findings, electrolyzer systems with balance of plant are observed to have a high level of controllability and hence can add flexibility to the grid from the demand side. A generic front end controller (FEC) is proposed, which enables an optimal operation of the load on themore » basis of market and grid conditions. This controller has been simulated and tested in a real-time environment with electrolyzer hardware for a performance assessment. It can optimize the operation of electrolyzer systems on the basis of the information collected by a communication module. Real-time simulation tests are performed to verify the performance of the FEC-driven electrolyzers to provide grid support that enables flexibility, greater economic revenue, and grid support for hydrogen producers under dynamic conditions. In conclusion, the FEC proposed in this paper is tested with electrolyzers, however, it is proposed as a generic control topology that is applicable to any load.« less

Evaluation of automated decisionmaking methodologies and development of an integrated robotic system simulation, appendix A

NASA Technical Reports Server (NTRS)

Haley, D. C.; Almand, B. J.; Thomas, M. M.; Krauze, L. D.; Gremban, K. D.; Sanborn, J. C.; Kelly, J. H.; Depkovich, T. M.

1984-01-01

A generic computer simulation for manipulator systems (ROBSIM) was implemented and the specific technologies necessary to increase the role of automation in various missions were developed. The specific items developed were: (1) Capability for definition of a manipulator system consisting of multiple arms, load objects, and an environment; (2) Capability for kinematic analysis, requirements analysis, and response simulation of manipulator motion; (3) Postprocessing options such as graphic replay of simulated motion and manipulator parameter plotting; (4) Investigation and simulation of various control methods including manual force/torque and active compliance control; (5) Evaluation and implementation of three obstacle avoidance methods; (6) Video simulation and edge detection; and (7) Software simulation validation. This appendix is the user's guide and includes examples of program runs and outputs as well as instructions for program use.

JEDI Wind Models | Jobs and Economic Development Impact Models | NREL

Science.gov Websites

Wind Models JEDI Wind Models The Jobs and Economic Development Impacts (JEDI) Wind model allows the user to estimate economic development impacts from wind power generation projects. JEDI Wind has default information that can be used to run a generic impacts analysis assuming wind industry averages

40 CFR 721.10411 - Alkanenitrile, bis(cyanoalkyl)amino (generic) (P-07-537).

Code of Federal Regulations, 2012 CFR

2012-07-01

... with N100 (if oil aerosols absent), R100, or P100 filters; NIOSH-certified powered air-purifying respirator equipped with a loose- fitting hood or helmet and high efficiency particulate air (HEPA) filters... HEPA filters; or NIOSH-certified supplied-air respirator operated in pressure demand or continuous flow...

40 CFR 721.10411 - Alkanenitrile, bis(cyanoalkyl)amino (generic) (P-07-537).

Code of Federal Regulations, 2013 CFR

2013-07-01

... with N100 (if oil aerosols absent), R100, or P100 filters; NIOSH-certified powered air-purifying respirator equipped with a loose- fitting hood or helmet and high efficiency particulate air (HEPA) filters... HEPA filters; or NIOSH-certified supplied-air respirator operated in pressure demand or continuous flow...

40 CFR 721.10411 - Alkanenitrile, bis(cyanoalkyl)amino (generic) (P-07-537).

Code of Federal Regulations, 2014 CFR

2014-07-01

... with N100 (if oil aerosols absent), R100, or P100 filters; NIOSH-certified powered air-purifying respirator equipped with a loose- fitting hood or helmet and high efficiency particulate air (HEPA) filters... HEPA filters; or NIOSH-certified supplied-air respirator operated in pressure demand or continuous flow...

40 CFR 721.10607 - Aliphatic diisocyanate, homopolymer, alkanol-blocked (generic).

Code of Federal Regulations, 2014 CFR

2014-07-01

...-purifying, tight-fitting half-face respirator equipped with N100 (if oil aerosols absent), R100, or P100 filters. (B) NIOSH-certified air-purifying, tight-fitting full-face respirator equipped with N100 (if oil...-certified powered air-purifying respirator equipped with a tight-fitting facepiece (either half-face or full...

40 CFR 721.9719 - Tris carbamoyl triazine (generic).

Code of Federal Regulations, 2012 CFR

2012-07-01

... the requirements for § 721.63(a)(4): (A) Air purifying, tight-fitting half-face respirator equipped... filter (N100 if oil aerosols are absent, R100, or P100); (B) Air purifying, tight-fitting full-face...) filter; powered air-purifying respirator equipped with tight-fitting facepiece (either half-face or full...

Strategic Implications of U.S. Fighter Force Reductions: Air-to-Air Combat Modeling Using Lanchester Equations

DTIC Science & Technology

2011-06-01

Retrieved from http://www.aviationweek.com/aw/generic/channel_awst.jsp?channel= awst on multiple occasions. Baron, Kevin. “Retiring Air Force...Defense. January 2011a. -----. “The Evolution of PRC Air Power.” Second Line of Defense. January 2011b. 70 Drew, Donald R . and others

75 FR 80545 - Carolina Power & Light Company; H.B. Robinson Steam Electric Plant, Unit No. 2; Environmental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

....B. Robinson Steam Electric Plant, Unit No. 2; Environmental Assessment and Finding of No Significant...), for operation of the H. B. Robinson Steam Electric Plant, Unit 2 (HBRSEP), located in Darlington... ``Generic Environmental Impact Statement for License Renewal of Nuclear Plants: H.B. Robinson Steam Electric...

75 FR 14641 - NextEra Energy Seabrook, LLC, et al.*; Seabrook Station, Unit No. 1; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-26

... generically extend the rule's compliance date for all operating nuclear power plants, but noted that the..., Nuclear Energy Institute). The licensee's request for an exemption is therefore consistent with the... or hereafter in effect. The facility consists of one pressurized water reactor located in Seabrook...

75 FR 16869 - Entergy Nuclear Operations, LLC; Palisades Nuclear Plant; Exemption

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-02

... generic industry request to extend the rule's compliance date for all operating nuclear power plants, but..., to M. S. Fertel, Nuclear Energy Institute). The licensee's request for an exemption is therefore... exemption will not have a significant effect on the quality of the human environment [75 FR 14473; dated...

The Role of Interest and Images in Slideware Presentations

ERIC Educational Resources Information Center

Tangen, Jason M.; Constable, Merryn D.; Durrant, Eric; Teeter, Chris; Beston, Brett R.; Kim, Joseph A.

2011-01-01

With the advent of technologies that allow lecturers to develop presentations using software such as Microsoft PowerPoint, Apple Keynote, and OpenOffice Impress (referred to generically here as "slideware"), lectures and meetings are beginning to resemble cinematic experiences rather than the text filled transactions that have been the norm for…

Excel Yourself with Personalised Email Messages

ERIC Educational Resources Information Center

McClean, Stephen

2008-01-01

Combining the Excel spreadsheet with an email program provides a very powerful tool for sending students personalised emails. Most email clients now support a Mail Merge facility whereby a generic template is created and information unique to each student record in the spreadsheet is filled into that template, generating tens if not hundreds of…

Unruh effect for general trajectories

NASA Astrophysics Data System (ADS)

Obadia, N.; Milgrom, M.

2007-03-01

We consider two-level detectors coupled to a scalar field and moving on arbitrary trajectories in Minkowski space-time. We first derive a generic expression for the response function using a (novel) regularization procedure based on the Feynman prescription that is explicitly causal, and we compare it to other expressions used in the literature. We then use this expression to study, analytically and numerically, the time dependence of the response function in various nonstationarity situations. We show that, generically, the response function decreases like a power in the detector’s level spacing, E, for high E. It is only for stationary worldlines that the response function decays faster than any power law, in keeping with the known exponential behavior for some stationary cases. Under some conditions the (time-dependent) response function for a nonstationary worldline is well approximated by the value of the response function for a stationary worldline having the same instantaneous acceleration, torsion, and hypertorsion. While we cannot offer general conditions for this to apply, we discuss special cases; in particular, the low-energy limit for linear space trajectories.

MHD compressor---expander conversion system integrated with GCR inside a deployable reflector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tuninetti, G.; Botta, E.; Criscuolo, C.

1989-04-20

This work originates from the proposal MHD Compressor-Expander Conversion System Integrated with a GCR Inside a Deployable Reflector''. The proposal concerned an innovative concept of nuclear, closed-cycle MHD converter for power generation on space-based systems in the multi-megawatt range. The basic element of this converter is the Power Conversion Unit (PCU) consisting of a gas core reactor directly coupled to an MHD expansion channel. Integrated with the PCU, a deployable reflector provides reactivity control. The working fluid could be either uranium hexafluoride or a mixture of uranium hexafluoride and helium, added to enhance the heat transfer properties. The original Statementmore » of Work, which concerned the whole conversion system, was subsequently redirected and focused on the basic mechanisms of neutronics, reactivity control, ionization and electrical conductivity in the PCU. Furthermore, the study was required to be inherently generic such that the study was required to be inherently generic such that the analysis an results can be applied to various nuclear reactor and/or MHD channel designs''.« less

A prioritization of generic safety issues. Supplement 19, Revision insertion instructions

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1995-11-01

The report presents the safety priority ranking for generic safety issues related to nuclear power plants. The purpose of these rankings is to assist in the timely and efficient allocation of NRC resources for the resolution of those safety issues that have a significant potential for reducing risk. The safety priority rankings are HIGH, MEDIUM, LOW, and DROP, and have been assigned on the basis of risk significance estimates, the ratio of risk to costs and other impacts estimated to result if resolution of the safety issues were implemented, and the consideration of uncertainties and other quantitative or qualitative factors.more » To the extent practical, estimates are quantitative. This document provides revisions and amendments to the report.« less

Simulation of an integrated system for the production of methane and single cell protein from biomass

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomas, M.V.

1989-01-01

A numerical model was developed to simulate the operation of an integrated system for the production of methane and single-cell algal protein from a variety of biomass energy crops or waste streams. Economic analysis was performed at the end of each simulation. The model was capable of assisting in the determination of design parameters by providing relative economic information for various strategies. Three configurations of anaerobic reactors were simulated. These included fed-bed reactors, conventional stirred tank reactors, and continuously expanding reactors. A generic anaerobic digestion process model, using lumped substrate parameters, was developed for use by type-specific reactor models. Themore » generic anaerobic digestion model provided a tool for the testing of conversion efficiencies and kinetic parameters for a wide range of substrate types and reactor designs. Dynamic growth models were used to model the growth of algae and Eichornia crassipes was modeled as a function of daily incident radiation and temperature. The growth of Eichornia crassipes was modeled for the production of biomass as a substrate for digestion. Computer simulations with the system model indicated that tropical or subtropical locations offered the most promise for a viable system. The availability of large quantities of digestible waste and low land prices were found to be desirable in order to take advantage of the economies of scale. Other simulations indicated that poultry and swine manure produced larger biogas yields than cattle manure. The model was created in a modular fashion to allow for testing of a wide variety of unit operations. Coding was performed in the Pascal language for use on personal computers.« less

Turbofan Engine Simulated in a Graphical Simulation Environment

NASA Technical Reports Server (NTRS)

Parker, Khary I.; Guo, Ten-Huei

2004-01-01

Recently, there has been an increase in the development of intelligent engine technology with advanced active component control. The computer engine models used in these control studies are component-level models (CLM), models that link individual component models of state space and nonlinear algebraic equations, written in a computer language such as Fortran. The difficulty faced in performing control studies on Fortran-based models is that Fortran is not supported with control design and analysis tools, so there is no means for implementing real-time control. It is desirable to have a simulation environment that is straightforward, has modular graphical components, and allows easy access to health, control, and engine parameters through a graphical user interface. Such a tool should also provide the ability to convert a control design into real-time code, helping to make it an extremely powerful tool in control and diagnostic system development. Simulation time management is shown: Mach number versus time, power level angle versus time, altitude versus time, ambient temperature change versus time, afterburner fuel flow versus time, controller and actuator dynamics, collect initial conditions, CAD output, and component-level model: CLM sensor, CAD input, and model output. The Controls and Dynamics Technologies Branch at the NASA Glenn Research Center has developed and demonstrated a flexible, generic turbofan engine simulation platform that can meet these objectives, known as the Modular Aero-Propulsion System Simulation (MAPSS). MAPSS is a Simulink-based implementation of a Fortran-based, modern high pressure ratio, dual-spool, low-bypass, military-type variable-cycle engine with a digital controller. Simulink (The Mathworks, Natick, MA) is a computer-aided control design and simulation package allows the graphical representation of dynamic systems in a block diagram form. MAPSS is a nonlinear, non-real-time system composed of controller and actuator dynamics (CAD) and component-level model (CLM) modules. The controller in the CAD module emulates the functionality of a digital controller, which has a typical update rate of 50 Hz. The CLM module simulates the dynamics of the engine components and uses an update rate of 2500 Hz, which is needed to iterate to balance mass and energy among system components. The actuators in the CAD module use the same sampling rate as those in the CLM. Two graphs of normalized spool speed versus time in seconds and one graph of normalized average metal temperature versus time in seconds is shown. MAPSS was validated via open-loop and closed-loop comparisons with the Fortran simulation. The preceding plots show the normalized results of a closed-loop comparison looking at three states of the model: low-pressure spool speed, high-pressure spool speed, and the average metal temperature measured from the combustor to the high-pressure turbine. In steady state, the error between the simulations is less than 1 percent. During a transient, the difference between the simulations is due to a correction in MAPSS that prevents the gas flow in the bypass duct inlet from flowing forward instead of toward the aft end, which occurs in the Fortran simulation. A comparison between MAPSS and the Fortran model of the bypass duct inlet flow for power lever angles greater than 35 degrees is shown.

BioASF: a framework for automatically generating executable pathway models specified in BioPAX.

PubMed

Haydarlou, Reza; Jacobsen, Annika; Bonzanni, Nicola; Feenstra, K Anton; Abeln, Sanne; Heringa, Jaap

2016-06-15

Biological pathways play a key role in most cellular functions. To better understand these functions, diverse computational and cell biology researchers use biological pathway data for various analysis and modeling purposes. For specifying these biological pathways, a community of researchers has defined BioPAX and provided various tools for creating, validating and visualizing BioPAX models. However, a generic software framework for simulating BioPAX models is missing. Here, we attempt to fill this gap by introducing a generic simulation framework for BioPAX. The framework explicitly separates the execution model from the model structure as provided by BioPAX, with the advantage that the modelling process becomes more reproducible and intrinsically more modular; this ensures natural biological constraints are satisfied upon execution. The framework is based on the principles of discrete event systems and multi-agent systems, and is capable of automatically generating a hierarchical multi-agent system for a given BioPAX model. To demonstrate the applicability of the framework, we simulated two types of biological network models: a gene regulatory network modeling the haematopoietic stem cell regulators and a signal transduction network modeling the Wnt/β-catenin signaling pathway. We observed that the results of the simulations performed using our framework were entirely consistent with the simulation results reported by the researchers who developed the original models in a proprietary language. The framework, implemented in Java, is open source and its source code, documentation and tutorial are available at http://www.ibi.vu.nl/programs/BioASF CONTACT: j.heringa@vu.nl. © The Author 2016. Published by Oxford University Press.

Using the bootstrap to establish statistical significance for relative validity comparisons among patient-reported outcome measures

PubMed Central

2013-01-01

Background Relative validity (RV), a ratio of ANOVA F-statistics, is often used to compare the validity of patient-reported outcome (PRO) measures. We used the bootstrap to establish the statistical significance of the RV and to identify key factors affecting its significance. Methods Based on responses from 453 chronic kidney disease (CKD) patients to 16 CKD-specific and generic PRO measures, RVs were computed to determine how well each measure discriminated across clinically-defined groups of patients compared to the most discriminating (reference) measure. Statistical significance of RV was quantified by the 95% bootstrap confidence interval. Simulations examined the effects of sample size, denominator F-statistic, correlation between comparator and reference measures, and number of bootstrap replicates. Results The statistical significance of the RV increased as the magnitude of denominator F-statistic increased or as the correlation between comparator and reference measures increased. A denominator F-statistic of 57 conveyed sufficient power (80%) to detect an RV of 0.6 for two measures correlated at r = 0.7. Larger denominator F-statistics or higher correlations provided greater power. Larger sample size with a fixed denominator F-statistic or more bootstrap replicates (beyond 500) had minimal impact. Conclusions The bootstrap is valuable for establishing the statistical significance of RV estimates. A reasonably large denominator F-statistic (F > 57) is required for adequate power when using the RV to compare the validity of measures with small or moderate correlations (r < 0.7). Substantially greater power can be achieved when comparing measures of a very high correlation (r > 0.9). PMID:23721463

Monte Carlo Simulation to Estimate Likelihood of Direct Lightning Strikes

NASA Technical Reports Server (NTRS)

Mata, Carlos; Medelius, Pedro

2008-01-01

A software tool has been designed to quantify the lightning exposure at launch sites of the stack at the pads under different configurations. In order to predict lightning strikes to generic structures, this model uses leaders whose origins (in the x-y plane) are obtained from a 2D random, normal distribution.

Knowledge mobilisation in healthcare: a critical review of health sector and generic management literature.

PubMed

Ferlie, Ewan; Crilly, Tessa; Jashapara, Ashok; Peckham, Anna

2012-04-01

The health policy domain has displayed increasing interest in questions of knowledge management and knowledge mobilisation within healthcare organisations. We analyse here the findings of a critical review of generic management and health-related literatures, covering the period 2000-2008. Using 29 pre-selected journals, supplemented by a search of selected electronic databases, we map twelve substantive domains classified into four broad groups: taxonomic and philosophical (e.g. different types of knowledge); theoretical discourse (e.g. critical organisational studies); disciplinary fields (e.g. organisational learning and Information Systems/Information Technology); and organisational processes and structures (e.g. organisational form). We explore cross-overs and gaps between these traditionally separate literature streams. We found that health sector literature has absorbed some generic concepts, notably Communities of Practice, but has not yet deployed the performance-oriented perspective of the Resource Based View (RBV) of the Firm. The generic literature uses healthcare sites to develop critical analyses of power and control in knowledge management, rooted in neo-Marxist/labour process and Foucauldian approaches. The review generates three theoretically grounded statements to inform future enquiry, by: (a) importing the RBV stream; (b) developing the critical organisational studies perspective further; and (c) exploring the theoretical argument that networks and other alternative organisational forms facilitate knowledge sharing. Copyright © 2012 Elsevier Ltd. All rights reserved.

Affordability of adult HIV/AIDS treatment in developing countries: modelling price determinants for a better insight of the market functioning.

PubMed

Sagaon-Teyssier, Luis; Singh, Sauman; Dongmo-Nguimfack, Boniface; Moatti, Jean-Paul

2016-01-01

This study aims to provide a landscape of the global antiretroviral (ARV) market by analyzing the transactional data on donor-funded ARV procurement between 2003 and 2015, and the ARV price determinants. The data were obtained from the Global Price Reporting Mechanism (GPRM) managed by the AIDS Medicines and Diagnostics Service of the WHO, and it consists of information that covers approximately 80% of the total donor-funded adult ARV transactions procurement. ExWorks prices and procured quantities were standardized according to the guidelines in terms of yearly doses. Descriptive statistics on quantities and prices show the main trends of the ARV market. Ordinary least squares estimation was carried out for the whole sample, then stratified according to the type of supplier (originator and generic) and controlled for time and geographical fixed-effects. Given that analyses were carried out on a public dataset on ARV transactional prices from the GPRM, ethics are respected and consent was not necessary. Originator medicines are on average the least expensive in the sub-Saharan Africa region, where at the same time, generic medicines are on average the most expensive. By contrast, originator medicines are the most expensive in Europe and Central Asia, and generic medicines are the least expensive. In fact, the data suggest mixed strategies by ARV suppliers to exploit opportunities for profit maximization and to adapt to the specific conditions of market competition in each region. Our results also suggest that the expiration of patents is not sufficient to boost additional developments in generic competition (at least in the ARV market) and that formal or informal agreements between generic firms may de facto slow down or even reverse long-term trends towards price decreases. Our findings provide an improved understanding of the ARV market that can help countries strengthen policy measures to increase their bargaining power in price negotiations and the use of TRIPS flexibilities, with a special emphasis on negotiations with generic manufacturers.

Using and comparing metaheuristic algorithms for optimizing bidding strategy viewpoint of profit maximization of generators

NASA Astrophysics Data System (ADS)

Mousavi, Seyed Hosein; Nazemi, Ali; Hafezalkotob, Ashkan

2015-03-01

With the formation of the competitive electricity markets in the world, optimization of bidding strategies has become one of the main discussions in studies related to market designing. Market design is challenged by multiple objectives that need to be satisfied. The solution of those multi-objective problems is searched often over the combined strategy space, and thus requires the simultaneous optimization of multiple parameters. The problem is formulated analytically using the Nash equilibrium concept for games composed of large numbers of players having discrete and large strategy spaces. The solution methodology is based on a characterization of Nash equilibrium in terms of minima of a function and relies on a metaheuristic optimization approach to find these minima. This paper presents some metaheuristic algorithms to simulate how generators bid in the spot electricity market viewpoint of their profit maximization according to the other generators' strategies, such as genetic algorithm (GA), simulated annealing (SA) and hybrid simulated annealing genetic algorithm (HSAGA) and compares their results. As both GA and SA are generic search methods, HSAGA is also a generic search method. The model based on the actual data is implemented in a peak hour of Tehran's wholesale spot market in 2012. The results of the simulations show that GA outperforms SA and HSAGA on computing time, number of function evaluation and computing stability, as well as the results of calculated Nash equilibriums by GA are less various and different from each other than the other algorithms.

A common mode of origin of power laws in models of market and earthquake

NASA Astrophysics Data System (ADS)

Bhattacharyya, Pratip; Chatterjee, Arnab; Chakrabarti, Bikas K.

2007-07-01

We show that there is a common mode of origin for the power laws observed in two different models: (i) the Pareto law for the distribution of money among the agents with random-saving propensities in an ideal gas-like market model and (ii) the Gutenberg-Richter law for the distribution of overlaps in a fractal-overlap model for earthquakes. We find that the power laws appear as the asymptotic forms of ever-widening log-normal distributions for the agents’ money and the overlap magnitude, respectively. The identification of the generic origin of the power laws helps in better understanding and in developing generalized views of phenomena in such diverse areas as economics and geophysics.

Global radioxenon emission inventory based on nuclear power reactor reports.

PubMed

Kalinowski, Martin B; Tuma, Matthias P

2009-01-01

Atmospheric radioactivity is monitored for the verification of the Comprehensive Nuclear-Test-Ban Treaty, with xenon isotopes 131mXe, 133Xe, 133mXe and 135Xe serving as important indicators of nuclear explosions. The treaty-relevant interpretation of atmospheric concentrations of radioxenon is enhanced by quantifying radioxenon emissions released from civilian facilities. This paper presents the first global radioxenon emission inventory for nuclear power plants, based on North American and European emission reports for the years 1995-2005. Estimations were made for all power plant sites for which emission data were unavailable. According to this inventory, a total of 1.3PBq of radioxenon isotopes are released by nuclear power plants as continuous or pulsed emissions in a generic year.

A Generic Nonlinear Aerodynamic Model for Aircraft

NASA Technical Reports Server (NTRS)

Grauer, Jared A.; Morelli, Eugene A.

2014-01-01

A generic model of the aerodynamic coefficients was developed using wind tunnel databases for eight different aircraft and multivariate orthogonal functions. For each database and each coefficient, models were determined using polynomials expanded about the state and control variables, and an othgonalization procedure. A predicted squared-error criterion was used to automatically select the model terms. Modeling terms picked in at least half of the analyses, which totalled 45 terms, were retained to form the generic nonlinear aerodynamic (GNA) model. Least squares was then used to estimate the model parameters and associated uncertainty that best fit the GNA model to each database. Nonlinear flight simulations were used to demonstrate that the GNA model produces accurate trim solutions, local behavior (modal frequencies and damping ratios), and global dynamic behavior (91% accurate state histories and 80% accurate aerodynamic coefficient histories) under large-amplitude excitation. This compact aerodynamics model can be used to decrease on-board memory storage requirements, quickly change conceptual aircraft models, provide smooth analytical functions for control and optimization applications, and facilitate real-time parametric system identification.

Simulation on change of generic satellite radar cross section via artificially created plasma sprays

NASA Astrophysics Data System (ADS)

Chung, Shen Shou Max; Chuang, Yu-Chou

2016-06-01

Recent advancements in antisatellite missile technologies have proven the effectiveness of such attacks, and the vulnerability of satellites in such exercises inspires a new paradigm in RF Stealth techniques suitable for satellites. In this paper we examine the possibility of using artificially created plasma sprays on the surface of the satellite’s main body to alter its radar cross section (RCS). First, we briefly review past research related to RF Stealth using plasma. Next, we discuss the physics between electromagnetic waves and plasma, and the RCS number game in RF Stealth design. A comparison of RCS in a generic satellite and a more complicated model is made to illustrate the effect of the RCS number game, and its meaning for a simulation model. We also run a comparison between finite-difference-time-domain (FDTD) and multilevel fast multipole method (MLFMM) codes, and find the RCS results are very close. We then compare the RCS of the generic satellite and the plasma-covered satellite. The incident radar wave is a differentiated Gaussian monopulse, with 3 dB bandwidth between 1.2 GHz and 4 GHz, and we simulate three kinds of plasma density, with a characteristic plasma frequency ω P  =  0.1, 1, and 10 GHz. The electron-neutral collision frequency ν en is set at 0.01 GHz. We found the RCS of plasma-covered satellite is not necessarily smaller than the originally satellite. When ω P is 0.1 GHz, the plasma spray behaves like a dielectric, and there is minor reduction in the RCS. When ω P is 1 GHz, the X-Y cut RCS increases. When ω P is 10 GHz, the plasma behaves more like a metal to the radar wave, and stronger RCS dependency to frequency appears. Therefore, to use plasma as an RCS adjustment tool requires careful fine-tuning of plasma density and shape, in order to achieve the so-called plasma stealth effect.

On the use of tower-flux measurements to assess the performance of global ecosystem models

NASA Astrophysics Data System (ADS)

El Maayar, M.; Kucharik, C.

2003-04-01

Global ecosystem models are important tools for the study of biospheric processes and their responses to environmental changes. Such models typically translate knowledge, gained from local observations, into estimates of regional or even global outcomes of ecosystem processes. A typical test of ecosystem models consists of comparing their output against tower-flux measurements of land surface-atmosphere exchange of heat and mass. To perform such tests, models are typically run using detailed information on soil properties (texture, carbon content,...) and vegetation structure observed at the experimental site (e.g., vegetation height, vegetation phenology, leaf photosynthetic characteristics,...). In global simulations, however, earth's vegetation is typically represented by a limited number of plant functional types (PFT; group of plant species that have similar physiological and ecological characteristics). For each PFT (e.g., temperate broadleaf trees, boreal conifer evergreen trees,...), which can cover a very large area, a set of typical physiological and physical parameters are assigned. Thus, a legitimate question arises: How does the performance of a global ecosystem model run using detailed site-specific parameters compare with the performance of a less detailed global version where generic parameters are attributed to a group of vegetation species forming a PFT? To answer this question, we used a multiyear dataset, measured at two forest sites with contrasting environments, to compare seasonal and interannual variability of surface-atmosphere exchange of water and carbon predicted by the Integrated BIosphere Simulator-Dynamic Global Vegetation Model. Two types of simulations were, thus, performed: a) Detailed runs: observed vegetation characteristics (leaf area index, vegetation height,...) and soil carbon content, in addition to climate and soil type, are specified for model run; and b) Generic runs: when only observed climates and soil types at the measurement sites are used to run the model. The generic runs were performed for the number of years equal to the current age of the forests, initialized with no vegetation and a soil carbon density equal to zero.

Propulsion System Simulation Using the Toolbox for the Modeling and Analysis of Thermodynamic System T-MATS

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Lavelle, Thomas M.; May, Ryan D.; Litt, Jonathan S.; Guo, Ten-Huei

2014-01-01

A simulation toolbox has been developed for the creation of both steady-state and dynamic thermodynamic software models. This paper describes the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS), which combines generic thermodynamic and controls modeling libraries with a numerical iterative solver to create a framework for the development of thermodynamic system simulations, such as gas turbine engines. The objective of this paper is to present an overview of T-MATS, the theory used in the creation of the module sets, and a possible propulsion simulation architecture. A model comparison was conducted by matching steady-state performance results from a T-MATS developed gas turbine simulation to a well-documented steady-state simulation. Transient modeling capabilities are then demonstrated when the steady-state T-MATS model is updated to run dynamically.

Propulsion System Simulation Using the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS)

NASA Technical Reports Server (NTRS)

Chapman, Jeffryes W.; Lavelle, Thomas M.; May, Ryan D.; Litt, Jonathan S.; Guo, Ten-Huei

2014-01-01

A simulation toolbox has been developed for the creation of both steady-state and dynamic thermodynamic software models. This paper describes the Toolbox for the Modeling and Analysis of Thermodynamic Systems (T-MATS), which combines generic thermodynamic and controls modeling libraries with a numerical iterative solver to create a framework for the development of thermodynamic system simulations, such as gas turbine engines. The objective of this paper is to present an overview of T-MATS, the theory used in the creation of the module sets, and a possible propulsion simulation architecture. A model comparison was conducted by matching steady-state performance results from a T-MATS developed gas turbine simulation to a well-documented steady-state simulation. Transient modeling capabilities are then demonstrated when the steady-state T-MATS model is updated to run dynamically.

Analysis of a DNA simulation model through hairpin melting experiments.

PubMed

Linak, Margaret C; Dorfman, Kevin D

2010-09-28

We compare the predictions of a two-bead Brownian dynamics simulation model to melting experiments of DNA hairpins with complementary AT or GC stems and noninteracting loops in buffer A. This system emphasizes the role of stacking and hydrogen bonding energies, which are characteristics of DNA, rather than backbone bending, stiffness, and excluded volume interactions, which are generic characteristics of semiflexible polymers. By comparing high throughput data on the open-close transition of various DNA hairpins to the corresponding simulation data, we (1) establish a suitable metric to compare the simulations to experiments, (2) find a conversion between the simulation and experimental temperatures, and (3) point out several limitations of the model, including the lack of G-quartets and cross stacking effects. Our approach and experimental data can be used to validate similar coarse-grained simulation models.

Using Dynamic Simulation to Evaluate Attemperator Operation in a Natural Gas Combined Cycle With Duct Burners in the Heat Recovery Steam Generator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liese, Eric; Zitney, Stephen E.

A generic training simulator of a natural gas combined cycle was modified to match operations at a real plant. The objective was to use the simulator to analyze cycling operations of the plant. Initial operation of the simulator revealed the potential for saturation conditions in the final high pressure superheater as the attemperator tried to control temperature at the superheater outlet during gas turbine loading and unloading. Subsequent plant operational data confirmed simulation results. Multiple simulations were performed during loading and unloading of the gas turbine to determine operational strategies that prevented saturation and increased the approach to saturation temperature.more » The solutions included changes to the attemperator temperature control setpoints and strategic control of the steam turbine inlet pressure control valve.« less

Power Laws, Scale Invariance and the Generalized Frobenius Series:

NASA Astrophysics Data System (ADS)

Visser, Matt; Yunes, Nicolas

We present a self-contained formalism for calculating the background solution, the linearized solutions and a class of generalized Frobenius-like solutions to a system of scale-invariant differential equations. We first cast the scale-invariant model into its equidimensional and autonomous forms, find its fixed points, and then obtain power-law background solutions. After linearizing about these fixed points, we find a second linearized solution, which provides a distinct collection of power laws characterizing the deviations from the fixed point. We prove that generically there will be a region surrounding the fixed point in which the complete general solution can be represented as a generalized Frobenius-like power series with exponents that are integer multiples of the exponents arising in the linearized problem. While discussions of the linearized system are common, and one can often find a discussion of power-series with integer exponents, power series with irrational (indeed complex) exponents are much rarer in the extant literature. The Frobenius-like series we encounter can be viewed as a variant of the rarely-discussed Liapunov expansion theorem (not to be confused with the more commonly encountered Liapunov functions and Liapunov exponents). As specific examples we apply these ideas to Newtonian and relativistic isothermal stars and construct two separate power series with the overlapping radius of convergence. The second of these power series solutions represents an expansion around "spatial infinity," and in realistic models it is this second power series that gives information about the stellar core, and the damped oscillations in core mass and core radius as the central pressure goes to infinity. The power-series solutions we obtain extend classical results; as exemplified for instance by the work of Lane, Emden, and Chandrasekhar in the Newtonian case, and that of Harrison, Thorne, Wakano, and Wheeler in the relativistic case. We also indicate how to extend these ideas to situations where fixed points may not exist — either due to "monotone" flow or due to the presence of limit cycles. Monotone flow generically leads to logarithmic deviations from scaling, while limit cycles generally lead to discrete self-similar solutions.

Traveling-wave tube reliability estimates, life tests, and space flight experience

NASA Technical Reports Server (NTRS)

Lalli, V. R.; Speck, C. E.

1977-01-01

Infant mortality, useful life, and wearout phase of twt life are considered. The performance of existing developmental tubes, flight experience, and sequential hardware testing are evaluated. The reliability history of twt's in space applications is documented by considering: (1) the generic parts of the tube in light of the manner in which their design and operation affect the ultimate reliability of the device, (2) the flight experience of medium power tubes, and (3) the available life test data for existing space-qualified twt's in addition to those of high power devices.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laros, James H.; Grant, Ryan; Levenhagen, Michael J.

Measuring and controlling the power and energy consumption of high performance computing systems by various components in the software stack is an active research area. Implementations in lower level software layers are beginning to emerge in some production systems, which is very welcome. To be most effective, a portable interface to measurement and control features would significantly facilitate participation by all levels of the software stack. We present a proposal for a standard power Application Programming Interface (API) that endeavors to cover the entire software space, from generic hardware interfaces to the input from the computer facility manager.

Low power signal processing electronics for wearable medical devices.

PubMed

Casson, Alexander J; Rodriguez-Villegas, Esther

2010-01-01

Custom designed microchips, known as Application Specific Integrated Circuits (ASICs), offer the lowest possible power consumption electronics. However, this comes at the cost of a longer, more complex and more costly design process compared to one using generic, off-the-shelf components. Nevertheless, their use is essential in future truly wearable medical devices that must operate for long periods of time from physically small, energy limited batteries. This presentation will demonstrate the state-of-the-art in ASIC technology for providing online signal processing for use in these wearable medical devices.

Powering the future - a new generation of high-performance solar arrays

NASA Astrophysics Data System (ADS)

Geyer, Freddy; Caswell, Doug; Signorini, Carla

2007-08-01

Funded by ESA's Advanced Research in Telecommunication (ARTES) programme, Thales Alenia Space has developed a new generation of high-power ultra-lightweight solar arrays for telecommunications satellites. Thanks to close cooperation with its industrial partners in Europe, the company has generically qualified a solar array io meet market needs. Indeed, three flight projects were already using the new design as qualification was completed. In addition, the excellent mechanical and thermal behaviour of the new panel structure are contributing to other missions such as Pleïades and LISA Pathfinder.

Price difference as a predictor of the selection between brand name and generic statins in Japan.

PubMed

Takizawa, Osamu; Urushihara, Hisashi; Tanaka, Shiro; Kawakami, Koji

2015-05-01

This study aimed to explore the predictors of the selection between brand name drug (BR) and generic drug (GE) and to clarify the quantitative relationship about selection. We identified "incident users" who dispensed statins between April 2008 and June 2011 in commercially databases consisted of dispensing claims databases (DCD) of out-of-hospital pharmacies and hospital claims databases (HCD) of in-house pharmacies in Japan. Predictors of the selection between BR and GE, including price difference (PD), the price of BR, their interaction and percent change of the price of GE relative to BR were explored by logistic regression using DCD and HCD separately. We extracted records of 670 patients who have opportunity for selection both BR and GE. Logistic regression analysis demonstrated that PD, the price of BR, interaction between them, and prescriber affiliation were factors significantly associated with the selection in the DCD; logit (p)=9.735-0.251×PD-0.071×the price of BR+0.002×PD×the price of BR-1.816×affiliation+0.220×gender-0.008×age+0.038×monthly medical fee. PD was inversely proportional to BR choice in DCD and lead to the opposite result in HCD. Numerical simulation of selection revealed that the quantitative relationships heavily depend on situations. PD and the price of BR are predictors of the selection between BR and GE interactively in out-of-hospital pharmacies, but not in in-house pharmacies of medical facilities. Results may support policies which increase the power of out-of-hospital pharmacies for selection. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

High-performance, scalable optical network-on-chip architectures

NASA Astrophysics Data System (ADS)

Tan, Xianfang

The rapid advance of technology enables a large number of processing cores to be integrated into a single chip which is called a Chip Multiprocessor (CMP) or a Multiprocessor System-on-Chip (MPSoC) design. The on-chip interconnection network, which is the communication infrastructure for these processing cores, plays a central role in a many-core system. With the continuously increasing complexity of many-core systems, traditional metallic wired electronic networks-on-chip (NoC) became a bottleneck because of the unbearable latency in data transmission and extremely high energy consumption on chip. Optical networks-on-chip (ONoC) has been proposed as a promising alternative paradigm for electronic NoC with the benefits of optical signaling communication such as extremely high bandwidth, negligible latency, and low power consumption. This dissertation focus on the design of high-performance and scalable ONoC architectures and the contributions are highlighted as follow: 1. A micro-ring resonator (MRR)-based Generic Wavelength-routed Optical Router (GWOR) is proposed. A method for developing any sized GWOR is introduced. GWOR is a scalable non-blocking ONoC architecture with simple structure, low cost and high power efficiency compared to existing ONoC designs. 2. To expand the bandwidth and improve the fault tolerance of the GWOR, a redundant GWOR architecture is designed by cascading different type of GWORs into one network. 3. The redundant GWOR built with MRR-based comb switches is proposed. Comb switches can expand the bandwidth while keep the topology of GWOR unchanged by replacing the general MRRs with comb switches. 4. A butterfly fat tree (BFT)-based hybrid optoelectronic NoC (HONoC) architecture is developed in which GWORs are used for global communication and electronic routers are used for local communication. The proposed HONoC uses less numbers of electronic routers and links than its counterpart of electronic BFT-based NoC. It takes the advantages of GWOR in optical communication and BFT in non-uniform traffic communication and three-dimension (3D) implementation. 5. A cycle-accurate NoC simulator is developed to evaluate the performance of proposed HONoC architectures. It is a comprehensive platform that can simulate both electronic and optical NoCs. Different size HONoC architectures are evaluated in terms of throughput, latency and energy dissipation. Simulation results confirm that HONoC achieves good network performance with lower power consumption.

Securing Sensitive Flight and Engine Simulation Data Using Smart Card Technology

NASA Technical Reports Server (NTRS)

Blaser, Tammy M.

2003-01-01

NASA Glenn Research Center has developed a smart card prototype capable of encrypting and decrypting disk files required to run a distributed aerospace propulsion simulation. Triple Data Encryption Standard (3DES) encryption is used to secure the sensitive intellectual property on disk pre, during, and post simulation execution. The prototype operates as a secure system and maintains its authorized state by safely storing and permanently retaining the encryption keys only on the smart card. The prototype is capable of authenticating a single smart card user and includes pre simulation and post simulation tools for analysis and training purposes. The prototype's design is highly generic and can be used to protect any sensitive disk files with growth capability to urn multiple simulations. The NASA computer engineer developed the prototype on an interoperable programming environment to enable porting to other Numerical Propulsion System Simulation (NPSS) capable operating system environments.

40 CFR 721.10581 - Brominated polyurethane prepolymers of methylene diphenyl diisocyanate (MDI) (generic).

Code of Federal Regulations, 2014 CFR

2014-07-01

..., tight-fitting half-face respirator equipped with N100 (if oil aerosols absent), R100, or P100 filters. (B) NIOSH-certified air-purifying, tight-fitting full-face respirator equipped with N100 (if oil...-certified powered air-purifying respirator equipped with a tight-fitting facepiece (either half-face or full...

Self-organization of critical behavior in controlled general queueing models

NASA Astrophysics Data System (ADS)

Blanchard, Ph.; Hongler, M.-O.

2004-03-01

We consider general queueing models of the (G/G/1) type with service times controlled by the busy period. For feedback control mechanisms driving the system to very high traffic load, it is shown the busy period probability density exhibits a generic - {3}/{2} power law which is a typical mean field behavior of SOC models.

High-Speed Photographic Study of Wave Propagation and Impact Damage in Transparent Laminates

DTIC Science & Technology

2008-04-01

23 8.2 Generating Optimized Power Diagrams for FEM Analysis...dimensions which removes short edges (and areas) such that a larger time step in a subsequent FEM analysis can be used...a zone where most contacts have already failed.............32 Figure 47. Insufficiency of generic FEM approaches. A steel impactor hits an AlON

Simulating Open Quantum Systems with Hamiltonian Ensembles and the Nonclassicality of the Dynamics

NASA Astrophysics Data System (ADS)

Chen, Hong-Bin; Gneiting, Clemens; Lo, Ping-Yuan; Chen, Yueh-Nan; Nori, Franco

2018-01-01

The incoherent dynamical properties of open quantum systems are generically attributed to an ongoing correlation between the system and its environment. Here, we propose a novel way to assess the nature of these system-environment correlations by examining the system dynamics alone. Our approach is based on the possibility or impossibility to simulate open-system dynamics with Hamiltonian ensembles. As we show, such (im)possibility to simulate is closely linked to the system-environment correlations. We thus define the nonclassicality of open-system dynamics in terms of the nonexistence of a Hamiltonian-ensemble simulation. This classifies any nonunital open-system dynamics as nonclassical. We give examples for open-system dynamics that are unital and classical, as well as unital and nonclassical.

CMB temperature bispectrum induced by cosmic strings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hindmarsh, Mark; Ringeval, Christophe; Suyama, Teruaki

2009-10-15

The cosmic microwave background (CMB) bispectrum of the temperature anisotropies induced by a network of cosmic strings is derived for small angular scales, under the assumption that the principal cause of temperature fluctuations is the Gott-Kaiser-Stebbins effect. We provide analytical expressions for all isosceles triangle configurations in Fourier space. Their overall amplitude is amplified as the inverse cube of the angle and diverges for flat triangles. The isosceles configurations generically lead to a negative bispectrum with a power-law decay l{sup -6} for large multipole l. However, collapsed triangles are found to be associated with a positive bispectrum whereas the squeezedmore » triangles still exhibit negative values. We then compare our analytical estimates to a direct computation of the bispectrum from a set of 300 statistically independent temperature maps obtained from Nambu-Goto cosmic string simulations in a Friedmann-Lemaitre-Robertson-Walker universe. We find good agreement for the overall amplitude, the power-law behavior, and the angle dependency of the various triangle configurations. At l{approx}500 the cosmic string Gott-Kaiser-Stebbins effect contributes approximately the same equilateral CMB bispectrum amplitude as an inflationary model with |f{sub NL}{sup loc}|{approx_equal}10{sup 3}, if the strings contribute about 10% of the temperature power spectrum at l=10. Current bounds on f{sub NL} are not derived using cosmic string bispectrum templates, and so our f{sub NL} estimate cannot be used to derive bounds on strings. However it does suggest that string bispectrum templates should be included in the search of CMB non-Gaussianities.« less

Bridging Three Orders of Magnitude: Multiple Scattered Waves Sense Fractal Microscopic Structures via Dispersion

NASA Astrophysics Data System (ADS)

Lambert, Simon A.; Näsholm, Sven Peter; Nordsletten, David; Michler, Christian; Juge, Lauriane; Serfaty, Jean-Michel; Bilston, Lynne; Guzina, Bojan; Holm, Sverre; Sinkus, Ralph

2015-08-01

Wave scattering provides profound insight into the structure of matter. Typically, the ability to sense microstructure is determined by the ratio of scatterer size to probing wavelength. Here, we address the question of whether macroscopic waves can report back the presence and distribution of microscopic scatterers despite several orders of magnitude difference in scale between wavelength and scatterer size. In our analysis, monosized hard scatterers 5 μ m in radius are immersed in lossless gelatin phantoms to investigate the effect of multiple reflections on the propagation of shear waves with millimeter wavelength. Steady-state monochromatic waves are imaged in situ via magnetic resonance imaging, enabling quantification of the phase velocity at a voxel size big enough to contain thousands of individual scatterers, but small enough to resolve the wavelength. We show in theory, experiments, and simulations that the resulting coherent superposition of multiple reflections gives rise to power-law dispersion at the macroscopic scale if the scatterer distribution exhibits apparent fractality over an effective length scale that is comparable to the probing wavelength. Since apparent fractality is naturally present in any random medium, microstructure can thereby leave its fingerprint on the macroscopically quantifiable power-law exponent. Our results are generic to wave phenomena and carry great potential for sensing microstructure that exhibits intrinsic fractality, such as, for instance, vasculature.

Trick Simulation Environment 07

NASA Technical Reports Server (NTRS)

Lin, Alexander S.; Penn, John M.

2012-01-01

The Trick Simulation Environment is a generic simulation toolkit used for constructing and running simulations. This release includes a Monte Carlo analysis simulation framework and a data analysis package. It produces all auto documentation in XML. Also, the software is capable of inserting a malfunction at any point during the simulation. Trick 07 adds variable server output options and error messaging and is capable of using and manipulating wide characters for international support. Wide character strings are available as a fundamental type for variables processed by Trick. A Trick Monte Carlo simulation uses a statistically generated, or predetermined, set of inputs to iteratively drive the simulation. Also, there is a framework in place for optimization and solution finding where developers may iteratively modify the inputs per run based on some analysis of the outputs. The data analysis package is capable of reading data from external simulation packages such as MATLAB and Octave, as well as the common comma-separated values (CSV) format used by Excel, without the use of external converters. The file formats for MATLAB and Octave were obtained from their documentation sets, and Trick maintains generic file readers for each format. XML tags store the fields in the Trick header comments. For header files, XML tags for structures and enumerations, and the members within are stored in the auto documentation. For source code files, XML tags for each function and the calling arguments are stored in the auto documentation. When a simulation is built, a top level XML file, which includes all of the header and source code XML auto documentation files, is created in the simulation directory. Trick 07 provides an XML to TeX converter. The converter reads in header and source code XML documentation files and converts the data to TeX labels and tables suitable for inclusion in TeX documents. A malfunction insertion capability allows users to override the value of any simulation variable, or call a malfunction job, at any time during the simulation. Users may specify conditions, use the return value of a malfunction trigger job, or manually activate a malfunction. The malfunction action may consist of executing a block of input file statements in an action block, setting simulation variable values, call a malfunction job, or turn on/off simulation jobs.

High performance visual display for HENP detectors

NASA Astrophysics Data System (ADS)

McGuigan, Michael; Smith, Gordon; Spiletic, John; Fine, Valeri; Nevski, Pavel

2001-08-01

A high end visual display for High Energy Nuclear Physics (HENP) detectors is necessary because of the sheer size and complexity of the detector. For BNL this display will be of special interest because of STAR and ATLAS. To load, rotate, query, and debug simulation code with a modern detector simply takes too long even on a powerful work station. To visualize the HENP detectors with maximal performance we have developed software with the following characteristics. We develop a visual display of HENP detectors on BNL multiprocessor visualization server at multiple level of detail. We work with general and generic detector framework consistent with ROOT, GAUDI etc, to avoid conflicting with the many graphic development groups associated with specific detectors like STAR and ATLAS. We develop advanced OpenGL features such as transparency and polarized stereoscopy. We enable collaborative viewing of detector and events by directly running the analysis in BNL stereoscopic theatre. We construct enhanced interactive control, including the ability to slice, search and mark areas of the detector. We incorporate the ability to make a high quality still image of a view of the detector and the ability to generate animations and a fly through of the detector and output these to MPEG or VRML models. We develop data compression hardware and software so that remote interactive visualization will be possible among dispersed collaborators. We obtain real time visual display for events accumulated during simulations.

Physics of Core-Collapse Supernovae in Three Dimensions: A Sneak Preview

NASA Astrophysics Data System (ADS)

Janka, Hans-Thomas; Melson, Tobias; Summa, Alexander

2016-10-01

Nonspherical mass motions are a generic feature of core-collapse supernovae, and hydrodynamic instabilities play a crucial role in the explosion mechanism. The first successful neutrino-driven explosions could be obtained with self-consistent, first-principles simulations in three spatial dimensions. But three-dimensional (3D) models tend to be less prone to explosion than the corresponding axisymmetric two-dimensional (2D) ones. The reason is that 3D turbulence leads to energy cascading from large to small spatial scales, the inverse of the 2D case, thus disfavoring the growth of buoyant plumes on the largest scales. Unless the inertia to explode simply reflects a lack of sufficient resolution in relevant regions, some important component of robust and sufficiently energetic neutrino-powered explosions may still be missing. Such a deficit could be associated with progenitor properties such as rotation, magnetic fields, or precollapse perturbations, or with microphysics that could cause enhancement of neutrino heating behind the shock. 3D simulations have also revealed new phenomena that are not present in 2D ones, such as spiral modes of the standing accretion shock instability (SASI) and a stunning dipolar lepton-number emission self-sustained asymmetry (LESA). Both impose time- and direction-dependent variations on the detectable neutrino signal. The understanding of these effects and of their consequences is still in its infancy.

An Open Source Simulation Model for Soil and Sediment Bioturbation

PubMed Central

Schiffers, Katja; Teal, Lorna Rachel; Travis, Justin Mark John; Solan, Martin

2011-01-01

Bioturbation is one of the most widespread forms of ecological engineering and has significant implications for the structure and functioning of ecosystems, yet our understanding of the processes involved in biotic mixing remains incomplete. One reason is that, despite their value and utility, most mathematical models currently applied to bioturbation data tend to neglect aspects of the natural complexity of bioturbation in favour of mathematical simplicity. At the same time, the abstract nature of these approaches limits the application of such models to a limited range of users. Here, we contend that a movement towards process-based modelling can improve both the representation of the mechanistic basis of bioturbation and the intuitiveness of modelling approaches. In support of this initiative, we present an open source modelling framework that explicitly simulates particle displacement and a worked example to facilitate application and further development. The framework combines the advantages of rule-based lattice models with the application of parameterisable probability density functions to generate mixing on the lattice. Model parameters can be fitted by experimental data and describe particle displacement at the spatial and temporal scales at which bioturbation data is routinely collected. By using the same model structure across species, but generating species-specific parameters, a generic understanding of species-specific bioturbation behaviour can be achieved. An application to a case study and comparison with a commonly used model attest the predictive power of the approach. PMID:22162997

An open source simulation model for soil and sediment bioturbation.

PubMed

Schiffers, Katja; Teal, Lorna Rachel; Travis, Justin Mark John; Solan, Martin

2011-01-01

Bioturbation is one of the most widespread forms of ecological engineering and has significant implications for the structure and functioning of ecosystems, yet our understanding of the processes involved in biotic mixing remains incomplete. One reason is that, despite their value and utility, most mathematical models currently applied to bioturbation data tend to neglect aspects of the natural complexity of bioturbation in favour of mathematical simplicity. At the same time, the abstract nature of these approaches limits the application of such models to a limited range of users. Here, we contend that a movement towards process-based modelling can improve both the representation of the mechanistic basis of bioturbation and the intuitiveness of modelling approaches. In support of this initiative, we present an open source modelling framework that explicitly simulates particle displacement and a worked example to facilitate application and further development. The framework combines the advantages of rule-based lattice models with the application of parameterisable probability density functions to generate mixing on the lattice. Model parameters can be fitted by experimental data and describe particle displacement at the spatial and temporal scales at which bioturbation data is routinely collected. By using the same model structure across species, but generating species-specific parameters, a generic understanding of species-specific bioturbation behaviour can be achieved. An application to a case study and comparison with a commonly used model attest the predictive power of the approach.

Development of the Tensoral Computer Language

NASA Technical Reports Server (NTRS)

Ferziger, Joel; Dresselhaus, Eliot

1996-01-01

The research scientist or engineer wishing to perform large scale simulations or to extract useful information from existing databases is required to have expertise in the details of the particular database, the numerical methods and the computer architecture to be used. This poses a significant practical barrier to the use of simulation data. The goal of this research was to develop a high-level computer language called Tensoral, designed to remove this barrier. The Tensoral language provides a framework in which efficient generic data manipulations can be easily coded and implemented. First of all, Tensoral is general. The fundamental objects in Tensoral represent tensor fields and the operators that act on them. The numerical implementation of these tensors and operators is completely and flexibly programmable. New mathematical constructs and operators can be easily added to the Tensoral system. Tensoral is compatible with existing languages. Tensoral tensor operations co-exist in a natural way with a host language, which may be any sufficiently powerful computer language such as Fortran, C, or Vectoral. Tensoral is very-high-level. Tensor operations in Tensoral typically act on entire databases (i.e., arrays) at one time and may, therefore, correspond to many lines of code in a conventional language. Tensoral is efficient. Tensoral is a compiled language. Database manipulations are simplified optimized and scheduled by the compiler eventually resulting in efficient machine code to implement them.

Mechanisms of Active Aerodynamic Load Reduction on a Rotorcraft Fuselage With Rotor Effects

NASA Technical Reports Server (NTRS)

Schaeffler, Norman W.; Allan, Brian G.; Jenkins, Luther N.; Yao, Chung-Sheng; Bartram, Scott M.; Mace, W. Derry; Wong, Oliver D.; Tanner, Philip E.

2016-01-01

The reduction of the aerodynamic load that acts on a generic rotorcraft fuselage by the application of active flow control was investigated in a wind tunnel test conducted on an approximately 1/3-scale powered rotorcraft model simulating forward flight. The aerodynamic mechanisms that make these reductions, in both the drag and the download, possible were examined in detail through the use of the measured surface pressure distribution on the fuselage, velocity field measurements made in the wake directly behind the ramp of the fuselage and computational simulations. The fuselage tested was the ROBIN-mod7, which was equipped with a series of eight slots located on the ramp section through which flow control excitation was introduced. These slots were arranged in a U-shaped pattern located slightly downstream of the baseline separation line and parallel to it. The flow control excitation took the form of either synthetic jets, also known as zero-net-mass-flux blowing, and steady blowing. The same set of slots were used for both types of excitation. The differences between the two excitation types and between flow control excitation from different combinations of slots were examined. The flow control is shown to alter the size of the wake and its trajectory relative to the ramp and the tailboom and it is these changes to the wake that result in a reduction in the aerodynamic load.

Continuations of the nonlinear Schrödinger equation beyond the singularity

NASA Astrophysics Data System (ADS)

Fibich, G.; Klein, M.

2011-07-01

We present four continuations of the critical nonlinear Schrödinger equation (NLS) beyond the singularity: (1) a sub-threshold power continuation, (2) a shrinking-hole continuation for ring-type solutions, (3) a vanishing nonlinear-damping continuation and (4) a complex Ginzburg-Landau (CGL) continuation. Using asymptotic analysis, we explicitly calculate the limiting solutions beyond the singularity. These calculations show that for generic initial data that lead to a loglog collapse, the sub-threshold power limit is a Bourgain-Wang solution, both before and after the singularity, and the vanishing nonlinear-damping and CGL limits are a loglog solution before the singularity, and have an infinite-velocity expanding core after the singularity. Our results suggest that all NLS continuations share the universal feature that after the singularity time Tc, the phase of the singular core is only determined up to multiplication by eiθ. As a result, interactions between post-collapse beams (filaments) become chaotic. We also show that when the continuation model leads to a point singularity and preserves the NLS invariance under the transformation t → -t and ψ → ψ*, the singular core of the weak solution is symmetric with respect to Tc. Therefore, the sub-threshold power and the shrinking-hole continuations are symmetric with respect to Tc, but continuations which are based on perturbations of the NLS equation are generically asymmetric.

Do Optomechanical Metasurfaces Run Out of Time?

PubMed

Viaene, Sophie; Ginis, Vincent; Danckaert, Jan; Tassin, Philippe

2018-05-11

Artificially structured metasurfaces make use of specific configurations of subwavelength resonators to efficiently manipulate electromagnetic waves. Additionally, optomechanical metasurfaces have the desired property that their actual configuration may be tuned by adjusting the power of a pump beam, as resonators move to balance pump-induced electromagnetic forces with forces due to elastic filaments or substrates. Although the reconfiguration time of optomechanical metasurfaces crucially determines their performance, the transient dynamics of unit cells from one equilibrium state to another is not understood. Here, we make use of tools from nonlinear dynamics to analyze the transient dynamics of generic optomechanical metasurfaces based on a damped-resonator model with one configuration parameter. We show that the reconfiguration time of optomechanical metasurfaces is not only limited by the elastic properties of the unit cell but also by the nonlinear dependence of equilibrium states on the pump power. For example, when switching is enabled by hysteresis phenomena, the reconfiguration time is seen to increase by over an order of magnitude. To illustrate these results, we analyze the nonlinear dynamics of a bilayer cross-wire metasurface whose optical activity is tuned by an electromagnetic torque. Moreover, we provide a lower bound for the configuration time of generic optomechanical metasurfaces. This lower bound shows that optomechanical metasurfaces cannot be faster than state-of-the-art switches at reasonable powers, even at optical frequencies.

Do Optomechanical Metasurfaces Run Out of Time?

NASA Astrophysics Data System (ADS)

Viaene, Sophie; Ginis, Vincent; Danckaert, Jan; Tassin, Philippe

2018-05-01

Artificially structured metasurfaces make use of specific configurations of subwavelength resonators to efficiently manipulate electromagnetic waves. Additionally, optomechanical metasurfaces have the desired property that their actual configuration may be tuned by adjusting the power of a pump beam, as resonators move to balance pump-induced electromagnetic forces with forces due to elastic filaments or substrates. Although the reconfiguration time of optomechanical metasurfaces crucially determines their performance, the transient dynamics of unit cells from one equilibrium state to another is not understood. Here, we make use of tools from nonlinear dynamics to analyze the transient dynamics of generic optomechanical metasurfaces based on a damped-resonator model with one configuration parameter. We show that the reconfiguration time of optomechanical metasurfaces is not only limited by the elastic properties of the unit cell but also by the nonlinear dependence of equilibrium states on the pump power. For example, when switching is enabled by hysteresis phenomena, the reconfiguration time is seen to increase by over an order of magnitude. To illustrate these results, we analyze the nonlinear dynamics of a bilayer cross-wire metasurface whose optical activity is tuned by an electromagnetic torque. Moreover, we provide a lower bound for the configuration time of generic optomechanical metasurfaces. This lower bound shows that optomechanical metasurfaces cannot be faster than state-of-the-art switches at reasonable powers, even at optical frequencies.

Design and Performance of a Miniature Radar L-Band Transceiver

NASA Technical Reports Server (NTRS)

McWatters, D.; Price, D.; Edelstein, W.

2004-01-01

Radar electronics developed for past JPL space missions historically had been custom designed and as such, given budgetary, time, and risk constraints, had not been optimized for maximum flexibility or miniaturization. To help reduce cost and risk of future radar missions, a generic radar module was conceived. The module includes a 1.25-GHz (L-band) transceiver and incorporates miniature high-density packaging of integrated circuits in die/chip form. The technology challenges include overcoming the effect of miniaturization and high packaging density to achieve the performance, reliability, and environmental ruggedness required for space missions. The module was chosen to have representative (generic) functionality most likely required from an L-band radar. For very large aperture phased-array spaceborne radar missions, the large dimensions of the array suggest the benefit of distributing the radar electronics into the antenna array. For such applications, this technology is essential in order to bring down the cost, mass, and power of the radar electronics module replicated in each panel of the array. For smaller sized arrays, a single module can be combined with the central radar controller and still provide the bene.ts of configuration .exibility, low power, and low mass. We present the design approach for the radar electronics module and the test results for its radio frequency (RF) portion: a miniature, low-power, radiation-hard L-band transceiver.

The generic task toolset: High level languages for the construction of planning and problem solving systems

NASA Technical Reports Server (NTRS)

Chandrasekaran, B.; Josephson, J.; Herman, D.

1987-01-01

The current generation of languages for the construction of knowledge-based systems as being at too low a level of abstraction is criticized, and the need for higher level languages for building problem solving systems is advanced. A notion of generic information processing tasks in knowledge-based problem solving is introduced. A toolset which can be used to build expert systems in a way that enhances intelligibility and productivity in knowledge acquistion and system construction is described. The power of these ideas is illustrated by paying special attention to a high level language called DSPL. A description is given of how it was used in the construction of a system called MPA, which assists with planning in the domain of offensive counter air missions.

Practical design considerations for photovoltaic power station

NASA Astrophysics Data System (ADS)

Swanson, T. D.

Aspects of photovoltaic (PV) technology are discussed along with generic PV design considerations, taking into account the resource sunlight, PV modules and their reliability, questions of PV system design, the support structure subsystem, and a power conditioning unit subsystem. A description is presented of two recent projects which demonstrate the translation of an idea into actual working PV systems. A privately financed project in Denton, Maryland, went on line in early December, 1982, and began providing power to the local utility grid. It represents the first intermediate size, grid-connected, privately financed power station in the U.S. Based on firm quotes, the actual cost of this system is about $13/W peak. The other project, called the PV Breeder, is an energy independent facility which utilizes solar power to make new solar cells. It is also the first large industrial structure completely powered by the sun.

Analysis of the Effect of Environmental Conditions in Conducting Amphibious Assaults Using a Ship Simulator/Vessel-Response Model Proof-of-Concept Study

DTIC Science & Technology

2017-05-01

Center ESRI Environmental Systems Research Institute GIS Geographic Information System HTML Hyper -Text Markup Language LCAC Landing Craft Air... loop .” The ship simulator bridge is generic in that its layout is similar to that found in a variety of ships. As shown in Figures 17 and 18, the...information stored in the geodatabases. The Hyper -Text Markup Language (HTML) capability built into ArcMap permits a planner to click on a vessel track and

A human operator simulator model of the NASA Terminal Configured Vehicle (TCV)

NASA Technical Reports Server (NTRS)

Glenn, F. A., III; Doane, S. M.

1981-01-01

A generic operator model called HOS was used to simulate the behavior and performance of a pilot flying a transport airplane during instrument approach and landing operations in order to demonstrate the applicability of the model to problems associated with interfacing a crew with a flight system. The model which was installed and operated on NASA Langley's central computing system is described. Preliminary results of its application to an investigation of an innovative display system under development in Langley's terminal configured vehicle program are considered.

NASA Tech Briefs, August 2013

NASA Technical Reports Server (NTRS)

2013-01-01

Topics covered include: Radial Internal Material Handling System (RIMS) for Circular Habitat Volumes; Conical Seat Shut-Off Valve; Impact-Actuated Digging Tool for Lunar Excavation; Flexible Mechanical Conveyors for Regolith Extraction and Transport; Remote Memory Access Protocol Target Node Intellectual Property; Soft Decision Analyzer; Distributed Prognostics and Health Management with a Wireless Network Architecture; Minimal Power Latch for Single-Slope ADCs; Bismuth Passivation Technique for High-Resolution X-Ray Detectors; High-Strength, Super-elastic Compounds; Cu-Cr-Nb-Zr Alloy for Rocket Engines and Other High-Heat- Flux Applications; Microgravity Storage Vessels and Conveying-Line Feeders for Cohesive Regolith; CRUQS: A Miniature Fine Sun Sensor for Nanosatellites; On-Chip Microfluidic Components for In Situ Analysis, Separation, and Detection of Amino Acids; Spectroscopic Determination of Trace Contaminants in High-Purity Oxygen; Method of Separating Oxygen From Spacecraft Cabin Air to Enable Extravehicular Activities; Atomic Force Microscope Mediated Chromatography; Sample Analysis at Mars Instrument Simulator; Access Control of Web- and Java-Based Applications; Tool for Automated Retrieval of Generic Event Tracks (TARGET); Bilayer Protograph Codes for Half-Duplex Relay Channels; Influence of Computational Drop Representation in LES of a Droplet-Laden Mixing Layer.

A framework for the design and development of physical employment tests and standards.

PubMed

Payne, W; Harvey, J

2010-07-01

Because operational tasks in the uniformed services (military, police, fire and emergency services) are physically demanding and incur the risk of injury, employment policy in these services is usually competency based and predicated on objective physical employment standards (PESs) based on physical employment tests (PETs). In this paper, a comprehensive framework for the design of PETs and PESs is presented. Three broad approaches to physical employment testing are described and compared: generic predictive testing; task-related predictive testing; task simulation testing. Techniques for the selection of a set of tests with good coverage of job requirements, including job task analysis, physical demands analysis and correlation analysis, are discussed. Regarding individual PETs, theoretical considerations including measurability, discriminating power, reliability and validity, and practical considerations, including development of protocols, resource requirements, administrative issues and safety, are considered. With regard to the setting of PESs, criterion referencing and norm referencing are discussed. STATEMENT OF RELEVANCE: This paper presents an integrated and coherent framework for the development of PESs and hence provides a much needed theoretically based but practically oriented guide for organisations seeking to establish valid and defensible PESs.

Toward an Accurate Theoretical Framework for Describing Ensembles for Proteins under Strongly Denaturing Conditions

PubMed Central

Tran, Hoang T.; Pappu, Rohit V.

2006-01-01

Our focus is on an appropriate theoretical framework for describing highly denatured proteins. In high concentrations of denaturants, proteins behave like polymers in a good solvent and ensembles for denatured proteins can be modeled by ignoring all interactions except excluded volume (EV) effects. To assay conformational preferences of highly denatured proteins, we quantify a variety of properties for EV-limit ensembles of 23 two-state proteins. We find that modeled denatured proteins can be best described as follows. Average shapes are consistent with prolate ellipsoids. Ensembles are characterized by large correlated fluctuations. Sequence-specific conformational preferences are restricted to local length scales that span five to nine residues. Beyond local length scales, chain properties follow well-defined power laws that are expected for generic polymers in the EV limit. The average available volume is filled inefficiently, and cavities of all sizes are found within the interiors of denatured proteins. All properties characterized from simulated ensembles match predictions from rigorous field theories. We use our results to resolve between conflicting proposals for structure in ensembles for highly denatured states. PMID:16766618

A generic hydrological model for a green roof drainage layer.

PubMed

Vesuviano, Gianni; Stovin, Virginia

2013-01-01

A rainfall simulator of length 5 m and width 1 m was used to supply constant intensity and largely spatially uniform water inflow events to 100 different configurations of commercially available green roof drainage layer and protection mat. The runoff from each inflow event was collected and sampled at one-second intervals. Time-series runoff responses were subsequently produced for each of the tested configurations, using the average response of three repeat tests. Runoff models, based on storage routing (dS/dt = I-Q) and a power-law relationship between storage and runoff (Q = kS(n)), and incorporating a delay parameter, were created. The parameters k, n and delay were optimized to best fit each of the runoff responses individually. The range and pattern of optimized parameter values was analysed with respect to roof and event configuration. An analysis was performed to determine the sensitivity of the shape of the runoff profile to changes in parameter values. There appears to be potential to consolidate values of n by roof slope and drainage component material.

Feasibility study of a mini fuel cell to detect interference from a cellular phone

NASA Astrophysics Data System (ADS)

Abdullah, M. O.; Gan, Y. K.

Fuel cells produce electricity without involving combustion processes. They generate no noise, vibration or air pollution and are therefore suitable for use in many vibration-free power-generating applications. In this study, a mini alkaline fuel cell signal detector system has been designed, constructed and tested. The initial results have shown the applicability of such system for used as an indicator of signal disturbance from cellular phones. A small disturbance even at 4 mV cm -1, corresponding to an amplitude of 12-18 mG in terms of electromagnetic field, can be well detected by such a device. Subsequently, a thermodynamics model has been developed to provide a parametric study by simulation to show the likely performance of the fuel cell alone in other environments. As such the model can provide many useful generic design data for alkaline fuel cells. Two general conclusions can be drawn from the present theoretical study: (i) fuel cell performance increases with temperature, pressure and correction factor, C f; (ii) the temperature factor (E/ T) increases with increasing temperature and with increasing pressure factor.

Lightweight Filter Architecture for Energy Efficient Mobile Vehicle Localization Based on a Distributed Acoustic Sensor Network

PubMed Central

Kim, Keonwook

2013-01-01

The generic properties of an acoustic signal provide numerous benefits for localization by applying energy-based methods over a deployed wireless sensor network (WSN). However, the signal generated by a stationary target utilizes a significant amount of bandwidth and power in the system without providing further position information. For vehicle localization, this paper proposes a novel proximity velocity vector estimator (PVVE) node architecture in order to capture the energy from a moving vehicle and reject the signal from motionless automobiles around the WSN node. A cascade structure between analog envelope detector and digital exponential smoothing filter presents the velocity vector-sensitive output with low analog circuit and digital computation complexity. The optimal parameters in the exponential smoothing filter are obtained by analytical and mathematical methods for maximum variation over the vehicle speed. For stationary targets, the derived simulation based on the acoustic field parameters demonstrates that the system significantly reduces the communication requirements with low complexity and can be expected to extend the operation time considerably. PMID:23979482

Factors affecting economies of scale in combined sewer systems.

PubMed

Maurer, Max; Wolfram, Martin; Anja, Herlyn

2010-01-01

A generic model is introduced that represents the combined sewer infrastructure of a settlement quantitatively. A catchment area module first calculates the length and size distribution of the required sewer pipes on the basis of rain patterns, housing densities and area size. These results are fed into the sewer-cost module in order to estimate the combined sewer costs of the entire catchment area. A detailed analysis of the relevant input parameters for Swiss settlements is used to identify the influence of size on costs. The simulation results confirm that an economy of scale exists for combined sewer systems. This is the result of two main opposing cost factors: (i) increased construction costs for larger sewer systems due to larger pipes and increased rain runoff in larger settlements, and (ii) lower costs due to higher population and building densities in larger towns. In Switzerland, the more or less organically grown settlement structures and limited land availability emphasise the second factor to show an apparent economy of scale. This modelling approach proved to be a powerful tool for understanding the underlying factors affecting the cost structure for water infrastructures.

Power subsystem automation study

NASA Technical Reports Server (NTRS)

Imamura, M. S.; Moser, R. L.; Veatch, M.

1983-01-01

Generic power-system elements and their potential faults are identified. Automation functions and their resulting benefits are defined and automation functions between power subsystem, central spacecraft computer, and ground flight-support personnel are partitioned. All automation activities were categorized as data handling, monitoring, routine control, fault handling, planning and operations, or anomaly handling. Incorporation of all these classes of tasks, except for anomaly handling, in power subsystem hardware and software was concluded to be mandatory to meet the design and operational requirements of the space station. The key drivers are long mission lifetime, modular growth, high-performance flexibility, a need to accommodate different electrical user-load equipment, onorbit assembly/maintenance/servicing, and potentially large number of power subsystem components. A significant effort in algorithm development and validation is essential in meeting the 1987 technology readiness date for the space station.

Remote Learning for the Manipulation and Control of Robotic Cells

ERIC Educational Resources Information Center

Goldstain, Ofir; Ben-Gal, Irad; Bukchin, Yossi

2007-01-01

This work proposes an approach to remote learning of robotic cells based on internet and simulation tools. The proposed approach, which integrates remote-learning and tele-operation into a generic scheme, is designed to enable students and developers to set-up and manipulate a robotic cell remotely. Its implementation is based on a dedicated…

Validating the Modeling and Simulation of a Generic Tracking Radar

DTIC Science & Technology

2009-07-28

order Gauss-Markov time series with CTGM = 250 units and rGM = 10 s is shown in the top panel of Figure 1. The time series, ifr , can represent any...are shared among the sensors. The total position and velocity estimation errors valid at time index k are given by < fr *|fc = rk\\k - rk and

A Generic, Agent-Based Framework for Design and Development of UAV/UCAV Control Systems

DTIC Science & Technology

2004-02-27

37 EID Principles .................................................................................................. 38 Experimental Support for EID...Year 2 Interface design and implementation; creation of the simulation environment; Year 3 Demonstration of the concept and experimental evaluation...UAV/UCAV control in which operators can experience high cognitive workloads. There are several ways in which systems can construct user models by

Progress Towards Fuselage Drag Reduction via Active Flow Control: A Combined CFD and Experimental Effort

NASA Technical Reports Server (NTRS)

Schaeffler, Norman W.; Allan, Brian G.; Lienard, Caroline; LePape, Arnaud

2010-01-01

A combined computational and experimental effort has been undertaken to study fuselage drag reduction on a generic, non-proprietary rotorcraft fuselage by the application of active ow control. Fuselage drag reduction is an area of research interest to both the United States and France and this area is being worked collaboratively as a task under the United States/France Memorandum of Agreement on Helicopter Aeromechanics. In the first half of this task, emphasis is placed on the US generic fuselage, the ROBIN-mod7, with the experimental work being conducted on the US side and complementary US and French CFD analysis of the baseline and controlled cases. Fuselage simulations were made using Reynolds-averaged Navier-Stokes ow solvers and with multiple turbulence models. Comparisons were made to experimental data for numerical simulations of the isolated fuselage and for the fuselage as installed in the tunnel, which includes modeling of the tunnel contraction, walls, and support fairing. The numerical simulations show that comparisons to the experimental data are in good agreement when the tunnel and model support are included. The isolated fuselage simulations compare well to each other, however, there is a positive shift in the centerline pressure when compared to the experiment. The computed flow separation locations on the rear ramp region had only slight differences with and without the tunnel walls and model support. For the simulations, the flow control slots were placed at several locations around the flow separation lines as a series of eight slots that formed a nearly continuous U-shape. Results from the numerical simulations resulted in an estimated 35% fuselage drag reduction from a steady blowing flow control configuration and a 26% drag reduction for unsteady zero-net-mass flow control configuration. Simulations with steady blowing show a delayed flow separation at the rear ramp of the fuselage that increases the surface pressure acting on the ramp, thus decreasing the overall fuselage pressure drag.

Silica problem in the design of geothermal power plants

NASA Astrophysics Data System (ADS)

Dipippo, R.

1985-02-01

The silica problem is examined from the perspective of the power plant designer to develop a procedure to enable a quick estimate to be made of the potential seriousness of the silica deposition problem for a wide variety of resources and for selected types of power plant. The method employs correlations for the equilibrium solubilities of quartz and amorphous silica and for the saturated liquid enthalpy and the latent heat of water substance. Single- and double-flash plants optimized for highest thermodynamic efficiency are considered. Binary-type plants are included generically without mention of cycle specifics. The results are presented both graphically and in tabular form, and the governing equations will be given in an easily-programmable form.

A numerical and experimental comparison of human head phantoms for compliance testing of mobile telephone equipment.

PubMed

Christ, Andreas; Chavannes, Nicolas; Nikoloski, Neviana; Gerber, Hans-Ulrich; Poković, Katja; Kuster, Niels

2005-02-01

A new human head phantom has been proposed by CENELEC/IEEE, based on a large scale anthropometric survey. This phantom is compared to a homogeneous Generic Head Phantom and three high resolution anatomical head models with respect to specific absorption rate (SAR) assessment. The head phantoms are exposed to the radiation of a generic mobile phone (GMP) with different antenna types and a commercial mobile phone. The phones are placed in the standardized testing positions and operate at 900 and 1800 MHz. The average peak SAR is evaluated using both experimental (DASY3 near field scanner) and numerical (FDTD simulations) techniques. The numerical and experimental results compare well and confirm that the applied SAR assessment methods constitute a conservative approach.

Impulse-induced optimum signal amplification in scale-free networks.

PubMed

Martínez, Pedro J; Chacón, Ricardo

2016-04-01

Optimizing information transmission across a network is an essential task for controlling and manipulating generic information-processing systems. Here, we show how topological amplification effects in scale-free networks of signaling devices are optimally enhanced when the impulse transmitted by periodic external signals (time integral over two consecutive zeros) is maximum. This is demonstrated theoretically by means of a star-like network of overdamped bistable systems subjected to generic zero-mean periodic signals and confirmed numerically by simulations of scale-free networks of such systems. Our results show that the enhancer effect of increasing values of the signal's impulse is due to a correlative increase of the energy transmitted by the periodic signals, while it is found to be resonant-like with respect to the topology-induced amplification mechanism.

Automated subsystems control development. [for life support systems of space station

NASA Technical Reports Server (NTRS)

Block, R. F.; Heppner, D. B.; Samonski, F. H., Jr.; Lance, N., Jr.

1985-01-01

NASA has the objective to launch a Space Station in the 1990s. It has been found that the success of the Space Station engineering development, the achievement of initial operational capability (IOC), and the operation of a productive Space Station will depend heavily on the implementation of an effective automation and control approach. For the development of technology needed to implement the required automation and control function, a contract entitled 'Automated Subsystems Control for Life Support Systems' (ASCLSS) was awarded to two American companies. The present paper provides a description of the ASCLSS program. Attention is given to an automation and control architecture study, a generic automation and control approach for hardware demonstration, a standard software approach, application of Air Revitalization Group (ARG) process simulators, and a generic man-machine interface.

Phenomenological approach to mechanical damage growth analysis.

PubMed

Pugno, Nicola; Bosia, Federico; Gliozzi, Antonio S; Delsanto, Pier Paolo; Carpinteri, Alberto

2008-10-01

The problem of characterizing damage evolution in a generic material is addressed with the aim of tracing it back to existing growth models in other fields of research. Based on energetic considerations, a system evolution equation is derived for a generic damage indicator describing a material system subjected to an increasing external stress. The latter is found to fit into the framework of a recently developed phenomenological universality (PUN) approach and, more specifically, the so-called U2 class. Analytical results are confirmed by numerical simulations based on a fiber-bundle model and statistically assigned local strengths at the microscale. The fits with numerical data prove, with an excellent degree of reliability, that the typical evolution of the damage indicator belongs to the aforementioned PUN class. Applications of this result are briefly discussed and suggested.

A Preliminary Model for Spacecraft Propulsion Performance Analysis Based on Nuclear Gain and Subsystem Mass-Power Balances

NASA Technical Reports Server (NTRS)

Chakrabarti, S.; Schmidt, G. R.; Thio, Y. C.; Hurst, C. M.

1999-01-01

Rapid transportation of human crews to destinations throughout the solar system will require propulsion systems having not only very high exhaust velocities (i.e., I(sub sp) >= 10(exp 4) to 10(exp 5) sec) but also extremely low mass-power ratios (i.e., alpha <= 10(exp -2) kg/kW). These criteria are difficult to meet with electric propulsion and other power-limited systems, but may be achievable with propulsion concepts that use onboard power to produce a net gain in energy via fusion or some other nuclear process. This paper compares the fundamental performance of these gain-limited systems with that of power-limited systems, and determines from a generic power balance the gains required for ambitious planetary missions ranging up to 100 AU. Results show that energy gain reduces the required effective mass-power ratio of the system, thus enabling shorter trip times than those of power-limited concepts.

Modeling and Verification of Dependable Electronic Power System Architecture

NASA Astrophysics Data System (ADS)

Yuan, Ling; Fan, Ping; Zhang, Xiao-fang

The electronic power system can be viewed as a system composed of a set of concurrently interacting subsystems to generate, transmit, and distribute electric power. The complex interaction among sub-systems makes the design of electronic power system complicated. Furthermore, in order to guarantee the safe generation and distribution of electronic power, the fault tolerant mechanisms are incorporated in the system design to satisfy high reliability requirements. As a result, the incorporation makes the design of such system more complicated. We propose a dependable electronic power system architecture, which can provide a generic framework to guide the development of electronic power system to ease the development complexity. In order to provide common idioms and patterns to the system *designers, we formally model the electronic power system architecture by using the PVS formal language. Based on the PVS model of this system architecture, we formally verify the fault tolerant properties of the system architecture by using the PVS theorem prover, which can guarantee that the system architecture can satisfy high reliability requirements.

Numerical relativity waveform surrogate model for generically precessing binary black hole mergers

NASA Astrophysics Data System (ADS)

Blackman, Jonathan; Field, Scott E.; Scheel, Mark A.; Galley, Chad R.; Ott, Christian D.; Boyle, Michael; Kidder, Lawrence E.; Pfeiffer, Harald P.; Szilágyi, Béla

2017-07-01

A generic, noneccentric binary black hole (BBH) system emits gravitational waves (GWs) that are completely described by seven intrinsic parameters: the black hole spin vectors and the ratio of their masses. Simulating a BBH coalescence by solving Einstein's equations numerically is computationally expensive, requiring days to months of computing resources for a single set of parameter values. Since theoretical predictions of the GWs are often needed for many different source parameters, a fast and accurate model is essential. We present the first surrogate model for GWs from the coalescence of BBHs including all seven dimensions of the intrinsic noneccentric parameter space. The surrogate model, which we call NRSur7dq2, is built from the results of 744 numerical relativity simulations. NRSur7dq2 covers spin magnitudes up to 0.8 and mass ratios up to 2, includes all ℓ≤4 modes, begins about 20 orbits before merger, and can be evaluated in ˜50 ms . We find the largest NRSur7dq2 errors to be comparable to the largest errors in the numerical relativity simulations, and more than an order of magnitude smaller than the errors of other waveform models. Our model, and more broadly the methods developed here, will enable studies that were not previously possible when using highly accurate waveforms, such as parameter inference and tests of general relativity with GW observations.

Domain walls in the extensions of the Standard Model

NASA Astrophysics Data System (ADS)

Krajewski, Tomasz; Lalak, Zygmunt; Lewicki, Marek; Olszewski, Paweł

2018-05-01

Our main interest is the evolution of domain walls of the Higgs field in the early Universe. The aim of this paper is to understand how dynamics of Higgs domain walls could be influenced by yet unknown interactions from beyond the Standard Model. We assume that the Standard Model is valid up to certain, high, energy scale Λ and use the framework of the effective field theory to describe physics below that scale. Performing numerical simulations with different values of the scale Λ we are able to extend our previous analysis [1]. Our recent numerical simulations show that evolution of Higgs domain walls is rather insensitive to interactions beyond the Standard Model as long as masses of new particles are grater than 1012 GeV. For lower values of Λ the RG improved effective potential is strongly modified at field strengths crucial to the evolution of domain walls. However, we find that even for low values of Λ, Higgs domain walls decayed shortly after their formation for generic initial conditions. On the other hand, in simulations with specifically chosen initial conditions Higgs domain walls can live longer and enter the scaling regime. We also determine the energy spectrum of gravitational waves produced by decaying domain walls of the Higgs field. For generic initial field configurations the amplitude of the signal is too small to be observed in planned detectors.

A generic framework to simulate realistic lung, liver and renal pathologies in CT imaging

NASA Astrophysics Data System (ADS)

Solomon, Justin; Samei, Ehsan

2014-11-01

Realistic three-dimensional (3D) mathematical models of subtle lesions are essential for many computed tomography (CT) studies focused on performance evaluation and optimization. In this paper, we develop a generic mathematical framework that describes the 3D size, shape, contrast, and contrast-profile characteristics of a lesion, as well as a method to create lesion models based on CT data of real lesions. Further, we implemented a technique to insert the lesion models into CT images in order to create hybrid CT datasets. This framework was used to create a library of realistic lesion models and corresponding hybrid CT images. The goodness of fit of the models was assessed using the coefficient of determination (R2) and the visual appearance of the hybrid images was assessed with an observer study using images of both real and simulated lesions and receiver operator characteristic (ROC) analysis. The average R2 of the lesion models was 0.80, implying that the models provide a good fit to real lesion data. The area under the ROC curve was 0.55, implying that the observers could not readily distinguish between real and simulated lesions. Therefore, we conclude that the lesion-modeling framework presented in this paper can be used to create realistic lesion models and hybrid CT images. These models could be instrumental in performance evaluation and optimization of novel CT systems.

Sustaining simulation training programmes--experience from maternity care.

PubMed

Ayres-de-Campos, D; Deering, S; Siassakos, D

2011-11-01

There is little scientific evidence to support the majority of simulation-based maternity training programmes, but some characteristics appear to be associated with sustainability. Among these are a clear institutional-level commitment to the course, strong leadership in course organisation, a curriculum relevant to clinical practice, a nonthreatening learning environment, the establishment of multiprofessional training and the use of simulators appropriate to the learning objectives. There is still some debate on whether simulation-based sessions should be carried out in dedicated training time outside normal working hours or in ad-hoc drills that are run during clinical sessions, whether they should be located in clinical areas, simulation centres, or both, and whether or not they should include standardised generic teamwork training sessions. In this review, we discuss the main characteristics that appear to make a simulation-based training programme a sustainable initiative. © 2011 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2011 RCOG.