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Sample records for genome horizons michael

  1. Exploring Horizons for Domestic Animal Genomics: Workshop Summary

    SciTech Connect

    Board on Agriculture and Natural Resources, Board on Life Sciences, Division on Earth and Life Studies, National Research Council by Robert Pool and Kim Waddell

    2002-09-03

    Recognizing the important contributions that genomics analysis can make to agriculture,production and companion animal science, evolutionary biology and human health with respect to the creation of models for genetic disorders, the National Academies convened a group of individuals to plan a public workshop that would (1) assess these contributions; (2) identify potential research directions for existing genomics programs; and (3) highlight the opportunities of a coordinated, multi-species genomics effort for the science and policymaking communities. Their efforts culminated in a workshop the goal of which was to focus on domestic animal genomics and its integration with other genomics and functional genomics projects. A summary and synthesis of the discussion was produced and is a factual account of what occurred at the workshop.

  2. New horizons in genome engineering of Drosophila melanogaster.

    PubMed

    Kondo, Shu

    2014-01-01

    Drosophila melanogaster has the longest history as a genetic model system and even in the present day remains the front runner in diverse fields of biology. However, lack of a convenient method to make specified modifications to endogenous genes has been a pain in the neck for many fly geneticists for decades. Synthetic nuclease technologies, especially the CRISPR/Cas9 system, hold great promise for a breakthrough. Synthetic nucleases are programmable nucleases that can be directed to cleave a specified sequence in the genome. Deleterious mutations can be efficiently induced by expression of a synthetic nuclease that targets a gene of interest. Precise modification of the target site, such as a reporter gene knock-in, is also possible by simultaneous delivery of a synthetic nuclease and a targeting vector. Here I summarize recent advances in synthetic nuclease technologies and discuss their possible applications to Drosophila genetics. PMID:24817756

  3. Genomic and physiological footprint of the Deepwater Horizon oil spill on resident marsh fishes

    PubMed Central

    Whitehead, Andrew; Dubansky, Benjamin; Bodinier, Charlotte; Garcia, Tzintzuni I.; Miles, Scott; Pilley, Chet; Raghunathan, Vandana; Roach, Jennifer L.; Walker, Nan; Walter, Ronald B.; Rice, Charles D.; Galvez, Fernando

    2012-01-01

    The biological consequences of the Deepwater Horizon oil spill are unknown, especially for resident organisms. Here, we report results from a field study tracking the effects of contaminating oil across space and time in resident killifish during the first 4 mo of the spill event. Remote sensing and analytical chemistry identified exposures, which were linked to effects in fish characterized by genome expression and associated gill immunohistochemistry, despite very low concentrations of hydrocarbons remaining in water and tissues. Divergence in genome expression coincides with contaminating oil and is consistent with genome responses that are predictive of exposure to hydrocarbon-like chemicals and indicative of physiological and reproductive impairment. Oil-contaminated waters are also associated with aberrant protein expression in gill tissues of larval and adult fish. These data suggest that heavily weathered crude oil from the spill imparts significant biological impacts in sensitive Louisiana marshes, some of which remain for over 2 mo following initial exposures. PMID:21949382

  4. Draft Genome Sequences for Oil-Degrading Bacterial Strains from Beach Sands Impacted by the Deepwater Horizon Oil Spill

    PubMed Central

    Overholt, Will A.; Green, Stefan J.; Marks, Kala P.; Venkatraman, Raghavee; Prakash, Om

    2013-01-01

    We report the draft genome sequences of 10 proteobacterial strains isolated from beach sands contaminated with crude oil discharged from the Deepwater Horizon spill, which were cultivated under aerobic and anaerobic conditions with crude oil as the sole carbon source. All strains contain multiple putative genes belonging to hydrocarbon degradation pathways. PMID:24356826

  5. Single-cell genomics reveals features of a Colwellia species that was dominant during the Deepwater Horizon oil spill

    PubMed Central

    Mason, Olivia U.; Han, James; Woyke, Tanja; Jansson, Janet K.

    2014-01-01

    During the Deepwater Horizon (DWH) oil spill in the Gulf of Mexico a deep-sea hydrocarbon plume developed resulting in a rapid succession of bacteria. Colwellia eventually supplanted Oceanospirillales, which dominated the plume early in the spill. These successional changes may have resulted, in part, from the changing composition and abundance of hydrocarbons over time. Colwellia abundance peaked when gaseous and simple aromatic hydrocarbons increased, yet the metabolic pathway used by Colwellia in hydrocarbon disposition is unknown. Here we used single-cell genomics to gain insights into the genome properties of a Colwellia enriched during the DWH deep-sea plume. A single amplified genome (SAG) of a Colwellia cell isolated from a DWH plume, closely related (avg. 98% 16S rRNA gene similarity) to other plume Colwellia, was sequenced and annotated. The SAG was similar to the sequenced isolate Colwellia psychrerythraea 34H (84% avg. nucleotide identity). Both had genes for denitrification, chemotaxis, and motility, adaptations to cold environments and a suite of nutrient acquisition genes. The Colwellia SAG may be capable of gaseous and aromatic hydrocarbon degradation, which contrasts with a DWH plume Oceanospirillales SAG which encoded non-gaseous n-alkane and cycloalkane degradation pathways. The disparate hydrocarbon degradation pathways are consistent with hydrocarbons that were abundant at different times in the deep-sea plume; first, non-gaseous n-alkanes and cycloalkanes that could be degraded by Oceanospirillales, followed by gaseous, and simple aromatic hydrocarbons that may have been degraded by Colwellia. These insights into the genomic properties of a Colwellia species, which were supported by existing metagenomic sequence data from the plume and DWH contaminated sediments, help further our understanding of the successional changes in the dominant microbial players in the plume over the course of the DWH spill. PMID:25071745

  6. Genomes of Planktonic Acidimicrobiales: Widening Horizons for Marine Actinobacteria by Metagenomics

    PubMed Central

    Mizuno, Carolina Megumi; Ghai, Rohit

    2015-01-01

    ABSTRACT The genomes of four novel marine Actinobacteria have been assembled from large metagenomic data sets derived from the Mediterranean deep chlorophyll maximum (DCM). These are the first marine representatives belonging to the order Acidimicrobiales and only the second group of planktonic marine Actinobacteria to be described. Their streamlined genomes and photoheterotrophic lifestyle suggest that they are planktonic, free-living microbes. A novel rhodopsin clade, acidirhodopsins, related to freshwater actinorhodopsins, was found in these organisms. Their genomes suggest a capacity to assimilate C2 compounds, some using the glyoxylate bypass and others with the ethylmalonyl-coenzyme A (CoA) pathway. They are also able to derive energy from dimethylsulfopropionate (DMSP), sulfonate, and carbon monoxide oxidation, all commonly available in the marine habitat. These organisms appear to be prevalent in the deep photic zone at or around the DCM. The presence of sister clades to the marine Acidimicrobiales in freshwater aquatic habitats provides a new example of marine-freshwater transitions with potential evolutionary insights. PMID:25670777

  7. Following Michael Faraday's Footprints

    NASA Astrophysics Data System (ADS)

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable for following Michael Faraday's footprints. There are many other places in Europe of special interest for the physics teacher,2,3 and some useful guides to help us visit places as "scientific travelers,"4,5 but this paper focuses on Michael Faraday and London. I have personally visited most of the places described below and found the experience to be really worthwhile.

  8. Goodbye Michael Gove

    ERIC Educational Resources Information Center

    Bassey, Michael

    2014-01-01

    Michael Gove was Secretary of State for Education from May 2010 to July 2014 when the Prime Minister sacked him. With strong opinions arising from his own life experiences and outstanding energy for reform, but severely limited understanding of education and a refusal to consult teachers and other professionals, he imposed half-baked ideas on the…

  9. Following Michael Faraday's Footprints

    ERIC Educational Resources Information Center

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

  10. Michael Faraday's Bicentenary.

    ERIC Educational Resources Information Center

    Williams, L. Pearce; And Others

    1991-01-01

    Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

  11. Michael Faraday, media man.

    PubMed

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles. PMID:16332391

  12. Michael Faraday, media man.

    PubMed

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles.

  13. Blog life: Michael Nielsen

    NASA Astrophysics Data System (ADS)

    Nielsen, Michael

    2008-08-01

    Who is the blog written by? Michael Nielsen is a theoretical physicist who, up until June, was based at the Perimeter Institute for Theoretical Physics in Waterloo, Canada. He is a pioneer of quantum computation, contributing significantly to the theory of entangled quantum states. Last year, however, he announced a major change in the focus of his research, which now centres on the development of new tools for scientific publication and collaboration.

  14. HORIZON SENSING

    SciTech Connect

    Larry G. Stolarczyk, Sc.D.

    2002-07-31

    Real-time horizon sensing (HS) on continuous mining (CM) machines is becoming an industry tool. Installation and testing of production-grade HS systems has been ongoing this quarter at Oxbow Mining Company, Monterey Coal Company (EXXON), FMC Trona, Twentymile Coal Company (RAG America), and SASOL Coal. Detailed monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (United States) and IEC (International) certification.

  15. Multi-tissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis)

    PubMed Central

    Dubansky, Benjamin; Whitehead, Andrew; Miller, Jeffrey; Rice, Charles D.; Galvez, Fernando

    2013-01-01

    The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish (Fundulus grandis) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL), and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver and gill tissue coincident with the arrival of contaminating oil, and up-regulation of cytochrome P4501A (CYP1A) protein in gill, liver, intestine and head kidney for over one year following peak landfall of oil (August, 2011) compared to fish collected from reference sites. Furthermore, laboratory exposures of Gulf killifish embryos to field-collected sediments from Grande Terre and Barataria Bay, LA also resulted in increased CYP1A and developmental abnormalities when exposed to sediments collected from oiled sites compared to exposure to sediments collected from a reference site. These data are predictive of population-level impacts in fish exposed to sediments from oiled locations along the Gulf of Mexico coast. PMID:23659337

  16. Multitissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis).

    PubMed

    Dubansky, Benjamin; Whitehead, Andrew; Miller, Jeffrey T; Rice, Charles D; Galvez, Fernando

    2013-05-21

    The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish ( Fundulus grandis ) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL) and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver and gill tissue coincident with the arrival of contaminating oil and up-regulation of cytochrome P4501A (CYP1A) protein in gill, liver, intestine, and head kidney for over one year following peak landfall of oil (August 2011) compared to fish collected from reference sites. Furthermore, laboratory exposures of Gulf killifish embryos to field-collected sediments from Grande Terre and Barataria Bay, LA, also resulted in increased CYP1A and developmental abnormalities when exposed to sediments collected from oiled sites compared to exposure to sediments collected from a reference site. These data are predictive of population-level impacts in fish exposed to sediments from oiled locations along the Gulf of Mexico coast. PMID:23659337

  17. Multitissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis).

    PubMed

    Dubansky, Benjamin; Whitehead, Andrew; Miller, Jeffrey T; Rice, Charles D; Galvez, Fernando

    2013-05-21

    The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish ( Fundulus grandis ) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL) and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver and gill tissue coincident with the arrival of contaminating oil and up-regulation of cytochrome P4501A (CYP1A) protein in gill, liver, intestine, and head kidney for over one year following peak landfall of oil (August 2011) compared to fish collected from reference sites. Furthermore, laboratory exposures of Gulf killifish embryos to field-collected sediments from Grande Terre and Barataria Bay, LA, also resulted in increased CYP1A and developmental abnormalities when exposed to sediments collected from oiled sites compared to exposure to sediments collected from a reference site. These data are predictive of population-level impacts in fish exposed to sediments from oiled locations along the Gulf of Mexico coast.

  18. Enantioselective Michael Addition of Water

    PubMed Central

    Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

    2015-01-01

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry. PMID:25529526

  19. Enantioselective Michael addition of water.

    PubMed

    Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

    2015-02-01

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry.

  20. HORIZON SENSING

    SciTech Connect

    Larry G. Stolarczyk

    2003-03-18

    With the aid of a DOE grant (No. DE-FC26-01NT41050), Stolar Research Corporation (Stolar) developed the Horizon Sensor (HS) to distinguish between the different layers of a coal seam. Mounted on mining machine cutter drums, HS units can detect or sense the horizon between the coal seam and the roof and floor rock, providing the opportunity to accurately mine the section of the seam most desired. HS also enables accurate cutting of minimum height if that is the operator's objective. Often when cutting is done out-of-seam, the head-positioning function facilitates a fixed mining height to minimize dilution. With this technology, miners can still be at a remote location, yet cut only the clean coal, resulting in a much more efficient overall process. The objectives of this project were to demonstrate the feasibility of horizon sensing on mining machines and demonstrate that Horizon Sensing can allow coal to be cut cleaner and more efficiently. Stolar's primary goal was to develop the Horizon Sensor (HS) into an enabling technology for full or partial automation or ''agile mining''. This technical innovation (R&D 100 Award Winner) is quickly demonstrating improvements in productivity and miner safety at several prominent coal mines in the United States. In addition, the HS system can enable the cutting of cleaner coal. Stolar has driven the HS program on the philosophy that cutting cleaner coal means burning cleaner coal. The sensor, located inches from the cutting bits, is based upon the physics principles of a Resonant Microstrip Patch Antenna (RMPA). When it is in proximity of the rock-coal interface, the RMPA impedance varies depending on the thickness of uncut coal. The impedance is measured by the computer-controlled electronics and then sent by radio waves to the mining machine. The worker at the machine can read the data via a Graphical User Interface, displaying a color-coded image of the coal being cut, and direct the machine appropriately. The Horizon Sensor

  1. Interview with Michael Gazzaniga.

    PubMed

    Gazzaniga, Michael

    2011-04-01

    Widely considered the father of the field of cognitive neuroscience, Professor Michael S. Gazzaniga is one of the world's premier neuroscientists. He founded the Center for Neuroscience at the University of California, Davis; the Center for Cognitive Neuroscience at Dartmouth College; the Cognitive Neuroscience Institute; Journal of Cognitive Neuroscience; and the Cognitive Neuroscience Society. He is currently the director of the Sage Center for the Study of the Mind at the University of California, Santa Barbara. Born on December 12, 1939 in Los Angeles and educated at Dartmouth College, he received his Ph.D. in psychobiology at the California Institute of Technology under the tutelage of Roger Sperry. As a graduate student, Professor Gazzaniga initiated the first lateralized testing of human split-brain patients, leading to a fundamental shift in our understanding of functional lateralization in the brain and how the cerebral hemispheres communicate with one another. His many scholarly publications and pioneering work during the last 50 years have produced significant contributions to our understanding of how the brain enables the mind. His landmark 1995 book for MIT Press, The Cognitive Neurosciences, now in its fourth edition, is recognized as the sourcebook for the field. He has also published many books accessible to a lay audience, including Mind Matters, Nature's Mind, and The Ethical Brain. PMID:21486292

  2. Interview with Michael Gazzaniga.

    PubMed

    Gazzaniga, Michael

    2011-04-01

    Widely considered the father of the field of cognitive neuroscience, Professor Michael S. Gazzaniga is one of the world's premier neuroscientists. He founded the Center for Neuroscience at the University of California, Davis; the Center for Cognitive Neuroscience at Dartmouth College; the Cognitive Neuroscience Institute; Journal of Cognitive Neuroscience; and the Cognitive Neuroscience Society. He is currently the director of the Sage Center for the Study of the Mind at the University of California, Santa Barbara. Born on December 12, 1939 in Los Angeles and educated at Dartmouth College, he received his Ph.D. in psychobiology at the California Institute of Technology under the tutelage of Roger Sperry. As a graduate student, Professor Gazzaniga initiated the first lateralized testing of human split-brain patients, leading to a fundamental shift in our understanding of functional lateralization in the brain and how the cerebral hemispheres communicate with one another. His many scholarly publications and pioneering work during the last 50 years have produced significant contributions to our understanding of how the brain enables the mind. His landmark 1995 book for MIT Press, The Cognitive Neurosciences, now in its fourth edition, is recognized as the sourcebook for the field. He has also published many books accessible to a lay audience, including Mind Matters, Nature's Mind, and The Ethical Brain.

  3. Genomic and Genotoxic Responses to Controlled Weathered-Oil Exposures Confirm and Extend Field Studies on Impacts of the Deepwater Horizon Oil Spill on Native Killifish

    PubMed Central

    Pilcher, Whitney; Miles, Scott; Tang, Song; Mayer, Greg; Whitehead, Andrew

    2014-01-01

    To understand the ecotoxicological impacts of the Deepwater Horizon oil spill, field studies provide a context for ecological realism but laboratory-based studies offer power for connecting biological effects with specific causes. As a complement to field studies, we characterized genome-wide gene expression responses of Gulf killifish (Fundulus grandis) to oil-contaminated waters in controlled laboratory exposures. Transcriptional responses to the highest concentrations of oiled water in the laboratory were predictive of field-observed responses that coincided with the timing and location of major oiling. The transcriptional response to the low concentration (∼10-fold lower than the high concentration) was distinct from the high concentration and was not predictive of major oiling in the field. The high concentration response was characterized by activation of the molecular signaling pathway that facilitates oil metabolism and oil toxicity. The high concentration also induced DNA damage. The low concentration invoked expression of genes that may support a compensatory response, including genes associated with regulation of transcription, cell cycle progression, RNA processing, DNA damage, and apoptosis. We conclude that the gene expression response detected in the field was a robust indicator of exposure to the toxic components of contaminating oil, that animals in the field were exposed to relatively high concentrations that are especially damaging to early life stages, and that such exposures can damage DNA. PMID:25208076

  4. Genomic and genotoxic responses to controlled weathered-oil exposures confirm and extend field studies on impacts of the Deepwater Horizon oil spill on native killifish.

    PubMed

    Pilcher, Whitney; Miles, Scott; Tang, Song; Mayer, Greg; Whitehead, Andrew

    2014-01-01

    To understand the ecotoxicological impacts of the Deepwater Horizon oil spill, field studies provide a context for ecological realism but laboratory-based studies offer power for connecting biological effects with specific causes. As a complement to field studies, we characterized genome-wide gene expression responses of Gulf killifish (Fundulus grandis) to oil-contaminated waters in controlled laboratory exposures. Transcriptional responses to the highest concentrations of oiled water in the laboratory were predictive of field-observed responses that coincided with the timing and location of major oiling. The transcriptional response to the low concentration (∼ 10-fold lower than the high concentration) was distinct from the high concentration and was not predictive of major oiling in the field. The high concentration response was characterized by activation of the molecular signaling pathway that facilitates oil metabolism and oil toxicity. The high concentration also induced DNA damage. The low concentration invoked expression of genes that may support a compensatory response, including genes associated with regulation of transcription, cell cycle progression, RNA processing, DNA damage, and apoptosis. We conclude that the gene expression response detected in the field was a robust indicator of exposure to the toxic components of contaminating oil, that animals in the field were exposed to relatively high concentrations that are especially damaging to early life stages, and that such exposures can damage DNA.

  5. Genomic and genotoxic responses to controlled weathered-oil exposures confirm and extend field studies on impacts of the Deepwater Horizon oil spill on native killifish.

    PubMed

    Pilcher, Whitney; Miles, Scott; Tang, Song; Mayer, Greg; Whitehead, Andrew

    2014-01-01

    To understand the ecotoxicological impacts of the Deepwater Horizon oil spill, field studies provide a context for ecological realism but laboratory-based studies offer power for connecting biological effects with specific causes. As a complement to field studies, we characterized genome-wide gene expression responses of Gulf killifish (Fundulus grandis) to oil-contaminated waters in controlled laboratory exposures. Transcriptional responses to the highest concentrations of oiled water in the laboratory were predictive of field-observed responses that coincided with the timing and location of major oiling. The transcriptional response to the low concentration (∼ 10-fold lower than the high concentration) was distinct from the high concentration and was not predictive of major oiling in the field. The high concentration response was characterized by activation of the molecular signaling pathway that facilitates oil metabolism and oil toxicity. The high concentration also induced DNA damage. The low concentration invoked expression of genes that may support a compensatory response, including genes associated with regulation of transcription, cell cycle progression, RNA processing, DNA damage, and apoptosis. We conclude that the gene expression response detected in the field was a robust indicator of exposure to the toxic components of contaminating oil, that animals in the field were exposed to relatively high concentrations that are especially damaging to early life stages, and that such exposures can damage DNA. PMID:25208076

  6. An Interview with Michael Maloney.

    ERIC Educational Resources Information Center

    Tucker, Bruce

    1989-01-01

    Michael Maloney--Appalachian advocate, activist, and community organizer in Cincinnati's Over-the-Rhine neighborhood since the mid-1960s--discusses two decades of racial relations in this blighted inner city neighborhood, and the emergence of an urban Appalachian "ethnic" consciousness among transplanted mountain people. Contains 15 references.…

  7. Michael Sadler and Comparative Education

    ERIC Educational Resources Information Center

    Phillips, David

    2006-01-01

    This paper examines the work in education of Michael Sadler (1861-1943). It covers his early years in Oxford, his time as director of the Department of Special Inquiries and Reports, his periods as professor of education in Manchester and as vice-chancellor in Leeds, and his return to Oxford as Master of University College, and it assesses the…

  8. Q&A: Michael Honey

    ERIC Educational Resources Information Center

    Helicher, Karl

    2007-01-01

    The mid-1960s saw civil rights victories in Congress during Lyndon B. Johnson's presidency. In "Going Down Jericho Road," Michael Honey wrote how Martin Luther King Jr.'s final focus showed that the struggle for black and working class parity continued. The 1968 Memphis sanitation workers strike was a gritty struggle won in the streets by a host…

  9. Michael Beitz: Objects of Communication

    ERIC Educational Resources Information Center

    Hoefferle, Mary

    2014-01-01

    For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

  10. A Conversation with Michael Byram

    ERIC Educational Resources Information Center

    Wagner, Manuela

    2013-01-01

    In language teaching, it has been universally acknowledged that students need not just knowledge and skill in the grammar of a language but also the ability to use the language in socially and culturally appropriate ways. In this article Michael Byram, who has been working on Intercultural Competence for quite some time in a variety of different…

  11. Michael Faraday vs. the Spiritualists

    NASA Astrophysics Data System (ADS)

    Hirshfeld, Alan

    2006-12-01

    In the 1850s, renowned physicist Michael Faraday launched a public campaign against pseudoscience and spiritualism, which were rampant in England at the time. Faraday objected especially to claims that electrical or magnetic forces were responsible for paranormal phenomena, such as table-spinning and communication with the dead. Using scientific methods, Faraday unmasked the deceptions of spiritualists, clairvoyants and mediums and also laid bare the credulity of a public ill-educated in science. Despite his efforts, Victorian society's fascination with the paranormal swelled. Faraday's debacle anticipates current controversies about public science education and the interface between science and religion. This episode is one of many described in the new biography, The Electric Life of Michael Faraday (Walker & Co.), which chronicles Faraday's discoveries and his unlikely rise from poverty to the pinnacle of the English science establishment.

  12. Organocatalytic aza-Michael/retro-aza-Michael reaction: pronounced chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction.

    PubMed

    Cai, Yong-Feng; Li, Li; Luo, Meng-Xian; Yang, Ke-Fang; Lai, Guo-Qiao; Jiang, Jian-Xiong; Xu, Li-Wen

    2011-05-01

    A detailed experimental investigation of an aza-Michael reaction of aniline and chalcone is presented. A series of Cinchona alkaloid-derived organocatalysts with different functional groups were prepared and used in the aza-Michael and retro-aza-Michael reaction. There was an interesting finding that a complete reversal of stereoselectivity when a benzoyl group was introduced to the cinchonine and cinchonidine. The chirality amplification vs. time proceeds in the quinine-derived organocatalyst containing silicon-based bulky group, QN-TBS, -catalyzed aza-Michael reaction under solvent-free conditions. In addition, we have demonstrated for the first time that racemization was occurred in suitable solvents under mild conditions due to retro-aza-Michael reaction of the Michael adduct of aniline with chalcone. These indicate the equilibrium of retro-aza-Michael reaction and aza-Michael reaction produce the happening of chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction under different conditions, which would be beneficial to the development of novel chiral catalysts for the aza-Michael reactions.

  13. Beyond the horizon

    SciTech Connect

    Einhorn, Martin B; Mahato, Manavendra

    2006-05-15

    Cosmic horizons arise in general relativity in the context of black holes and in certain cosmologies. Classically, regions beyond a horizon are inaccessible to causal observers. However, quantum mechanical correlations may exist across horizons that may influence local observations. For the case of de Sitter space, we show how a single particle excitation behind the horizon changes the density matrix governing local observables. As compared to the vacuum state, we calculate the change in the average energy and entropy per unit volume. This illustrates what may be a generic property allowing some features of spacetime beyond a horizon to be inferred.

  14. Jack Michael's Motivation

    ERIC Educational Resources Information Center

    Miguel, Caio F.

    2013-01-01

    Among many of Jack Michael's contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of "motivating operation" (MO) by outlining its development from Skinner's (1938) notion of "drive." Conceptually, Michael's term helped us change our focus on…

  15. Method for promoting Michael addition reactions

    DOEpatents

    Shah, Pankaj V.; Vietti, David E.; Whitman, David William

    2010-09-21

    Homogeneously dispersed solid reaction promoters having an average particle size from 0.01 .mu.m to 500 .mu.m are disclosed for preparing curable mixtures of at least one Michael donor and at least one Michael acceptor. The resulting curable mixtures are useful as coatings, adhesives, sealants and elastomers.

  16. Ron Dittemore and Michael Kostelnik

    NASA Technical Reports Server (NTRS)

    2003-01-01

    Ronald D. Dittemore (right), a 26-year NASA veteran, announces his intention to step aside as the Space Shuttle Program Manager at the Johnson Space Center in Houston to pursue other opportunities. Also pictured at the Washington, DC announcement is Michael Kostelnik, Deputy Associate Administrator for the Space Shuttle and International Space Station Programs. Dittemore, who has served as the Shuttle Program Manager for more than four years, will remain in his current position until the Columbia Accident Investigation Board finishes its investigation and a complete 'Return to Flight' path has been established. Dittemore retired recently, he had publicly planned to do so before the accident. For more information on STS-107, please see GRIN Columbia General Explanation

  17. Test pilot Michael R. Swann

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Michael R. Swann joined the National Aeronautics and Space Administration's Dryden Flight Research Center on June 5, 1978, transferring from the NASA's Johnson Space Center, Houston, Texas, as a research pilot. Swann attended North Dakota State University, Fargo, North Dakota, from September 1968 to February 1977, where he earned his Masters in Physics. He was a member of three national honorary scholastic fraternities. Prior to joining NASA Swann served concurrently as an Aerospace Defense Command Interceptor pilot in the Air National Guard for five years and as a college physics instructor at North Dakota State University for two years. While at Johnson Space Center Mike was a pilot on high altitude earth resources and air sampling missions. He was also an instructor and check pilot for the Astronaut Space Flight Readiness Training program. As a Dryden research pilot Mike was involved with the F-111 #778 Transonic Aircraft Technology (TACT) program, F-15 # 281 Shuttle Tile tests, programs on the F-8C #802 and the PA-30 #808 Remotely Piloted Research Vehicle. He flew the Bell 47G #822 helicopter in support of research with the three-eighths-scale F-15 Spin Research Vehicle. On March 28, 1979, Mike made a pilot familiarization flight in the YF-12A #935. He also flew support flights in the F-104, C-47, T-37, T-38, and the Jetstar aircraft. Michael R. Swann was born June 5, 1949, in Fargo, North Dakota; he was fatally injured in a recreational glider accident on July 28, 1981, near California City, California.

  18. A general organocatalyzed Michael-Michael cascade reaction generates functionalized cyclohexenes.

    PubMed

    McGarraugh, Patrick G; Jones, Joshua H; Brenner-Moyer, Stacey E

    2011-08-01

    Although β-dicarbonyl compounds are regularly employed as Michael donors, intermediates arising from the Michael addition of unsaturated β-ketoesters to α,β-unsaturated aldehydes are susceptible to multiple subsequent reaction pathways. We designed cyclic unsaturated β-ketoester substrates that enabled the development of the first diphenyl prolinol silyl ether catalyzed Michael-Michael cascade reaction initiated by a β-dicarbonyl Michael donor to form cyclohexene products. The reaction conditions we developed for this Michael-Michael cascade reaction were also amenable to a variety of linear unsaturated β-ketoester substrates, including some of the same linear unsaturated β-ketoester substrates that were previously ineffective in Michael-Michael cascade reactions. These studies thus revealed that a change in simple reaction conditions, such as solvent and additives, enables the same substrate to undergo different cascade reactions, thereby accessing different molecular scaffolds. These studies also culminated in the development of a general organocatalyzed Michael-Michael cascade reaction that generates highly functionalized cyclohexenes with up to four stereocenters, in up to 97% yield, 32:1 dr, and 99% ee, in a single step from a variety of unsaturated β-ketoesters.

  19. The 2010 Horizon Report

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Smith, R.; Stone, S.

    2010-01-01

    The annual "Horizon Report" describes the continuing work of the New Media Consortium's Horizon Project, a qualitative research project established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, or creative inquiry on college and university campuses within the next five years. The…

  20. Two Horizons of Fusion

    ERIC Educational Resources Information Center

    Lo, Mun Ling; Chik, Pakey Pui Man

    2016-01-01

    In this paper, we aim to differentiate the internal and external horizons of "fusion." "Fusion" in the internal horizon relates to the structure and meaning of the object of learning as experienced by the learner. It clarifies the interrelationships among an object's critical features and aspects. It also illuminates the…

  1. Semiclassical ultraextremal horizons

    SciTech Connect

    Matyjasek, Jerzy; Zaslavskii, O.B.

    2005-04-15

    We examine backreaction of quantum massive fields on multiply-degenerate (ultraextremal) horizons. It is shown that, under influence of the quantum backreaction, the horizon of such a kind moves to a new position near which the metric does not change its asymptotics, so the ultraextremal black holes and cosmological spacetimes do exist as self-consistent solutions of the semiclassical field equations.

  2. Michael Thackeray on Lithium-air Batteries

    ScienceCinema

    Thackeray, Michael

    2016-07-12

    Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

  3. ASK Talks with Dr. Michael Hecht

    NASA Technical Reports Server (NTRS)

    Hecht, Michael

    2003-01-01

    Michael Hecht has been a member of NASA's Jet Propulsion Laboratory (JPL) staff since 1982. He is currently Project Manager and co-investigator for the Mars Environmental Compatibility Assessment (MECA)

  4. Diastereodivergent organocatalytic asymmetric vinylogous Michael reactions.

    PubMed

    Li, Xin; Lu, Min; Dong, Yun; Wu, Wenbin; Qian, Qingqing; Ye, Jinxing; Dixon, Darren J

    2014-07-24

    One of the major challenges of modern asymmetric catalysis is the ability to selectively control the formation of all diastereoisomers of reaction products possessing multiple stereocenters. Pioneers of such diastereodivergent catalytic asymmetric processes have focused on reactions where the newly formed stereogenic centres are proximal to the active carbonyl group. To date, however, diastereodivergent reactions at remote positions remain an unmet challenge. Herein, we describe a catalyst-controlled diastereodivergence in the formation of remote stereocenters in the direct vinylogous Michael reactions of β, γ-unsaturated butenolides to α, β-unsaturated ketones. The reactions are enabled by two complementary, non-enantiomeric multifunctional catalysts, which mutually activate and organise both reactants, affording either the syn- or anti-adduct with high diastereo- and enantioselectivity. These two catalytic systems are also applicable in the Mukaiyama-Michael reactions and tandem Michael-Michael reactions.

  5. ATV2 Interview with Michael Suffredini

    NASA Video Gallery

    International Space Station Manager Michael Suffredini answers questions about the European Space Agency’s second Automated Transfer Vehicle (ATV2), Johannes Kepler, set to launch from a launch p...

  6. Enantioselective synthesis of hindered cyclic dialkyl ethers via catalytic oxa-Michael/Michael desymmetrization†

    PubMed Central

    Corbett, Michael T.; Johnson, Jeffrey S.

    2014-01-01

    An asymmetric oxa-Michael/Michael cascade reaction of p-quinols and α,β-unsaturated aldehydes provides access to hindered dialkyl ethers. A highly enantioselective oxa-Michael addition of a tertiary alcohol precedes an intramolecular cyclohexadienone desymmetrization, which allows for the concomitant formation of four contiguous stereocenters in a single step. The highly functionalized bicyclic frameworks are rapidly obtained from simple starting materials with good diastereoselection and serve as valuable precursors for further manipulation. PMID:24683449

  7. Reversible Michael additions: covalent inhibitors and prodrugs.

    PubMed

    Johansson, Martin H

    2012-11-01

    Covalent inhibition is an efficient molecular mechanism for inhibiting enzymes or modulating the function of proteins and is found in the action of many drugs and biologically active natural products. However, it is has been less appreciated that the formation of covalent bonds can be reversible or irreversible. This review focuses on biologically active compounds that are Michael acceptors and how the reversible nature of the Michael addition reaction influences biological activity and how this can be exploited in designing prodrugs.

  8. [Early career of Michael Sendivogius].

    PubMed

    Prinke, Rafał T

    2012-01-01

    One of the most influential alchemical authors of the early modern period was Michael Sendivogius whose early life is shrouded in mystery. He may be labelled the most famous Polish scientific writer between Copernicus and Marie Skłodowska-Curie, but because of the difficulties involved in researching the biography of any alchemist, there has been relatively little interest in him among Polish historians. The early work of Roman Bugaj (author of the still fundamental monograph) and Włodzimierz Hubicki (who made his research available to the international community) has been continued only by the English-born Zbigniew Szydło and the author of this article. The roots of many legends about Sendivogius were three mid-17th century short biographies, none of which is trustworthy, so it is crucial to verify the received myth and the version constructed in the 1960's and 1970's with primary sources and evidence from the recent "new historiography of alchemy". The present article examines them in the light of newly discovered sources and reinterpretation of the old ones. The genealogy of the Sedzimir family is discussed at length to show that Sendivogius most probably was not its member but only a pretender in order to assume (or prove) the status of a nobleman. Several possible hypotheses about his origins are presented. He is known to have studied at three universities (Leipzig, Vienna and Altdorf) but authors of early panegyrics dedicated to Sendivogius list more universities which he may have attended. The most interesting is that of Cambridge, listed as the first one, because practically no Poles or Czechs went there at the time. Finally, his marriage to Veronica Stiebar, a wealthy widow of a Franconian knightly family, and her interesting family relationships (links to Erasmus, Camerarius, Paracelsus and the original Doctor Faustus) are discussed. The period covered is that before Sendivogius moved to Prague in about 1597, having already been a courtier of Rudolf II

  9. Direct Diastereo- and Enantioselective Vinylogous Michael Additions of Linear Enones.

    PubMed

    Guo, Qunsheng; Fraboni, Americo J; Brenner-Moyer, Stacey E

    2016-06-01

    A direct vinylogous Michael addition using linear vinylogous Michael donors has been developed. Notably, even γ-substituted Michael donors cleanly afforded γ-alkylated products in high yield and ee by this method. Moreover, control experiments revealed that, for these and related linear vinylogous Michael donors, the size of the Michael acceptor strongly influences whether α- or γ-alkylation occurs, not simply blocking effects of cocatalysts as suggested previously.

  10. Parity horizons in shape dynamics

    NASA Astrophysics Data System (ADS)

    Herczeg, Gabriel

    2016-11-01

    I introduce the notion of a parity horizon, and show that many simple solutions of shape dynamics possess them. I show that the event horizons of the known asymptotically flat black hole solutions of shape dynamics are parity horizons and that this notion of parity implies that these horizons possess a notion of CPT invariance that can in some cases be extended to the solution as a whole. I present three new solutions of shape dynamics with parity horizons and find that not only do event horizons become parity horizons in shape dynamics, but observer-dependent horizons and Cauchy horizons do as well. The fact that Cauchy horizons become (singular) parity horizons suggests a general chronology protection mechanism in shape dynamics that prevents the formation of closed timelike curves.

  11. New Horizons at Pluto

    NASA Astrophysics Data System (ADS)

    Schenk, Paul; Nimmo, Francis

    2016-06-01

    The New Horizons mission has revealed Pluto and its moon Charon to be geologically active worlds. The familiar, yet exotic, landforms suggest that geologic processes operate similarly across the Solar System, even in its cold outer reaches.

  12. Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/Michael addition via dynamic kinetic resolution: access to highly functionalized chromans with three contiguous stereocenters.

    PubMed

    Yang, Wen; Yang, Yi; Du, Da-Ming

    2013-03-15

    An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa-Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.

  13. Firewall or smooth horizon?

    NASA Astrophysics Data System (ADS)

    Ori, Amos

    2016-01-01

    Almheiri, Marolf, Polchinski, and Sully pointed out that for a sufficiently old black hole (BH), the set of assumptions known as the complementarity postulates appears to be inconsistent with the assumption of local regularity at the horizon. They concluded that the horizon of an old BH is likely to be the locus of local irregularity, a "firewall". Here I point out that if one adopts a different assumption, namely that semiclassical physics holds throughout its anticipated domain of validity, then the inconsistency is avoided, and the horizon retains its regularity. In this alternative view-point, the vast portion of the original BH information remains trapped inside the BH throughout the semiclassical domain of evaporation, and possibly leaks out later on. This appears to be an inevitable outcome of semiclassical gravity (if assumed to apply throughout its anticipated domain of validity).

  14. Michael Slote and "Sentimentalist Moral Education"

    ERIC Educational Resources Information Center

    Wren, Thomas

    2010-01-01

    Although I think most of what Michael Slote asserts in his article "Sentimentalist moral education" is correct, I worry about three important ideas that are conspicuous by their absence. The first is the possibility that human emotions and feelings are inherently cognitive, which is never considered in his psychological account of empathy. The…

  15. Solving the Housing Equation: Michael P. Johnson

    ERIC Educational Resources Information Center

    Roach, Ronald

    2005-01-01

    Dr. Michael P. Johnson, an associate professor of management science and urban affairs at the H. John Heinz III School of Public Policy and Management at Carnegie Mellon University in Pittsburgh, is taking management science tools and innovative information technology applications to the housing field. Concerned that organizations that develop and…

  16. International Humanitarian Award: Michael G. Wessells

    ERIC Educational Resources Information Center

    American Psychologist, 2009

    2009-01-01

    Michael G. Wessells, recipient of the International Humanitarian Award, is cited for his pioneering and sustained contributions to the protection of children affected by armed conflict and to the development of international guidelines for the provision of community-based, culturally responsive psychosocial support in emergencies. Wessells has…

  17. Michael Polanyi 1891-1976: A Rememberance

    ERIC Educational Resources Information Center

    Manno, Bruno V.

    1977-01-01

    Michael Polanyi was on "JHP's" Board of Editors for many years, and his book, "Personal Knowledge", published in 1958, was an important factor in the development of humanistic psychology. This "rememberance" presents an overview of his personal background and the major outlines of his thought. (Editor/RK)

  18. Michael Gorman vs. Web 2.0

    ERIC Educational Resources Information Center

    Chronicle of Higher Education, 2007

    2007-01-01

    In a much-discussed series of postings on the Encyclopaedia Britannica Online Web site, Michael Gorman, former president of the American Library Association and the recently retired dean of library services at California State University at Fresno, argues that the "often-anarchic world of the Internet" is saturating people's culture with a "tide…

  19. Astronaut Michael L. Coats with camera.

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut Michael L. Coats positions himself for a photographic briefing during a training session for 41-D crewmembers in the Shuttle one-g trainer at the Johnson Space Center (JSC). Coats will assume pilot duties aboard the Space Shuttle Discovery for the scheduled seven-day 41-D mission in late June. This photograph was taken for NASA by Otis Imboden.

  20. Michael Walzer's Politics, in Theory and Practice

    ERIC Educational Resources Information Center

    Williams, Jeffrey J.

    2012-01-01

    Before all the talk about "public intellectuals," Michael Walzer was one. For 50 years, he has gone back and forth between positions at Princeton and Harvard Universities and then at the Institute for Advanced Study, in Princeton, New Jersey, where he is now emeritus. His writings appear regularly in "Dissent" magazine, which he has co-edited for…

  1. Comments on Michael (1993): Establishing Operations

    ERIC Educational Resources Information Center

    Moore, J.

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but…

  2. Michael and Malott's dialog on linguistic productivity.

    PubMed

    Michael, Jack; Malott, Richard W

    2003-01-01

    This is an informal dialog between Jack Michael and Dick Malott inspired by Malott's commentary (In press) on Relational Frame Theory: A Post-Skinnerian Account of Human Language and Cognition (Hayes, Barnes-Holmes, Roche; 2001). Topics range from psychologist Skinner to linguist Hockett and from the Skinner box to verbal behavior (AKA language).

  3. Against Dogma: A Reply to Michael Swan.

    ERIC Educational Resources Information Center

    Widdowson, H. G.

    1985-01-01

    Replies to two articles by Michael Swan entitled "A Critical Look at the Communicative Approach." Argues that Swan presents a distorted version of the communicative approach so as to present his own ideas more effectively and that he fails to offer evidence for his position on the practice of English language teaching. (SED)

  4. Reframing Michael Scott: Exploring Inappropriate Workplace Communication

    ERIC Educational Resources Information Center

    Schaefer, Zachary A.

    2010-01-01

    Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

  5. New Horizons in Thermodynamics

    NASA Astrophysics Data System (ADS)

    Hayward, Geoffrey Gordon

    1991-02-01

    This thesis collects five papers which treat the theory of horizon thermodynamics and its applications to cosmology. In the first paper I consider general, spherically symmetric spacetimes with cosmological and black hole horizons. I find that a state of thermal equilibrium may exist in classical manifolds with two horizons so long as a matter distribution is present. I calculate the Euclidean action for non-classical manifolds with and without boundary and relate it to the grand canonical weighting factor. I find that the mean thermal energy of the cosmological horizon is negative. In the second paper I derive the first law of thermodynamics for bounded, static, spherically symmetric spacetimes which include a matter distribution and either a black hole or cosmological horizon. I calculate heat capacities associated with matter/horizon systems and find that they may be positive or negative depending on the matter configuration. I discuss the case in which the cosmological constant is allowed to vary and conclude that the Hawking/Coleman mechanisms for explaining the low value of the cosmological constant are not well formulated. In the third paper, co-authored by Jorma Louko, we analyze variational principles for non-smooth metrics. These principles give insight to the problem of constructing minisuperspace path integrals in horizon statistical mechanics and quantum cosmology. We demonstrate that smoothness conditions can be derived from the variational principle as equations of motion. We suggest a new prescription for minisuperspace path integrals on the manifold | D times S^2. In the fourth paper, I examine the contribution of the horizon energy density to black hole temperature. I show the existence of positive heat capacity solutions in the small mass regime. In the fifth paper, co-authored by Diego Pavon we investigate the role of primordial black holes in the very early universe under SU(3) times SU(2) times U (1), SU(5), and their supersymmetric

  6. 4. Photocopy of inkandwatercolor drawing (from St. Michael's Church) Rambusch, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of ink-and-watercolor drawing (from St. Michael's Church) Rambusch, illustrator ca. 1932-37 INTERIOR, LOOKING NORTHEAST - St. Michael's Catholic Church, 519 East Third Street, Madison, Jefferson County, IN

  7. Organocatalyzed cascade aza-Michael/Michael addition for the asymmetric construction of highly functionalized spiropyrazolone tetrahydroquinolines.

    PubMed

    Li, Jun-Hua; Du, Da-Ming

    2014-11-01

    An organocatalyzed diastereo- and enantioselective cascade aza-Michael/Michael addition of 2-tosylaminoenones to unsaturated pyrazolones has been developed to afford novel chiral spiropyrazolone tetrahydroquinolines containing three contiguous stereocenters. This cascade reaction proceeded well with 2 mol% chiral bifunctional tertiary amine squaramide catalyst to give the desired products in excellent yields (up to 99%) with excellent diastereoselectivity (up to >25:1 diastereomeric ratio) and high enantioselectivity (up to 91% enantiomeric excess).

  8. Stable predictive control horizons

    NASA Astrophysics Data System (ADS)

    Estrada, Raúl; Favela, Antonio; Raimondi, Angelo; Nevado, Antonio; Requena, Ricardo; Beltrán-Carbajal, Francisco

    2012-04-01

    The stability theory of predictive and adaptive predictive control for processes of linear and stable nature is based on the hypothesis of a physically realisable driving desired trajectory (DDT). The formal theoretical verification of this hypothesis is trivial for processes with a stable inverse, but it is not for processes with an unstable inverse. The extended strategy of predictive control was developed with the purpose of overcoming methodologically this stability problem and it has delivered excellent performance and stability in its industrial applications given a suitable choice of the prediction horizon. From a theoretical point of view, the existence of a prediction horizon capable of ensuring stability for processes with an unstable inverse was proven in the literature. However, no analytical solution has been found for the determination of the prediction horizon values which guarantee stability, in spite of the theoretical and practical interest of this matter. This article presents a new method able to determine the set of prediction horizon values which ensure stability under the extended predictive control strategy formulation and a particular performance criterion for the design of the DDT generically used in many industrial applications. The practical application of this method is illustrated by means of simulation examples.

  9. Selective Michael Reaction Controlled by Supersilyl Protecting Group.

    PubMed

    Izumiseki, Atsuto; Yamamoto, Hisashi

    2015-07-20

    Selective Michael reaction of organolithium reagents to supersilyl methacrylate is reported. The method was able to control a single and double Michael addition. The successful termination of the process using the supersilyl protecting group allows for the controlled, chemoselective, and diastereoselective Michael reaction.

  10. Horizon as critical phenomenon

    NASA Astrophysics Data System (ADS)

    Lee, Sung-Sik

    2016-09-01

    We show that renormalization group flow can be viewed as a gradual wave function collapse, where a quantum state associated with the action of field theory evolves toward a final state that describes an IR fixed point. The process of collapse is described by the radial evolution in the dual holographic theory. If the theory is in the same phase as the assumed IR fixed point, the initial state is smoothly projected to the final state. If in a different phase, the initial state undergoes a phase transition which in turn gives rise to a horizon in the bulk geometry. We demonstrate the connection between critical behavior and horizon in an example, by deriving the bulk metrics that emerge in various phases of the U( N ) vector model in the large N limit based on the holographic dual constructed from quantum renormalization group. The gapped phase exhibits a geometry that smoothly ends at a finite proper distance in the radial direction. The geometric distance in the radial direction measures a complexity: the depth of renormalization group transformation that is needed to project the generally entangled UV state to a direct product state in the IR. For gapless states, entanglement persistently spreads out to larger length scales, and the initial state can not be projected to the direct product state. The obstruction to smooth projection at charge neutral point manifests itself as the long throat in the anti-de Sitter space. The Poincare horizon at infinity marks the critical point which exhibits a divergent length scale in the spread of entanglement. For the gapless states with non-zero chemical potential, the bulk space becomes the Lifshitz geometry with the dynamical critical exponent two. The identification of horizon as critical point may provide an explanation for the universality of horizon. We also discuss the structure of the bulk tensor network that emerges from the quantum renormalization group.

  11. Instability of enclosed horizons

    NASA Astrophysics Data System (ADS)

    Kay, Bernard S.

    2015-03-01

    We point out that there are solutions to the scalar wave equation on dimensional Minkowski space with finite energy tails which, if they reflect off a uniformly accelerated mirror due to (say) Dirichlet boundary conditions on it, develop an infinite stress-energy tensor on the mirror's Rindler horizon. We also show that, in the presence of an image mirror in the opposite Rindler wedge, suitable compactly supported arbitrarily small initial data on a suitable initial surface will develop an arbitrarily large stress-energy scalar near where the two horizons cross. Also, while there is a regular Hartle-Hawking-Israel-like state for the quantum theory between these two mirrors, there are coherent states built on it for which there are similar singularities in the expectation value of the renormalized stress-energy tensor. We conjecture that in other situations with analogous enclosed horizons such as a (maximally extended) Schwarzschild black hole in equilibrium in a (stationary spherical) box or the (maximally extended) Schwarzschild-AdS spacetime, there will be similar stress-energy singularities and almost-singularities—leading to instability of the horizons when gravity is switched on and matter and gravity perturbations are allowed for. All this suggests it is incorrect to picture a black hole in equilibrium in a box or a Schwarzschild-AdS black hole as extending beyond the past and future horizons of a single Schwarzschild (/Schwarzschild-AdS) wedge. It would thus provide new evidence for 't Hooft's brick wall model while seeming to invalidate the picture in Maldacena's ` Eternal black holes in AdS'. It would thereby also support the validity of the author's matter-gravity entanglement hypothesis and of the paper ` Brick walls and AdS/CFT' by the author and Ortíz.

  12. Spacetimes containing slowly evolving horizons

    SciTech Connect

    Kavanagh, William; Booth, Ivan

    2006-08-15

    Slowly evolving horizons are trapping horizons that are ''almost'' isolated horizons. This paper reviews their definition and discusses several spacetimes containing such structures. These include certain Vaidya and Tolman-Bondi solutions as well as (perturbatively) tidally distorted black holes. Taking into account the mass scales and orders of magnitude that arise in these calculations, we conjecture that slowly evolving horizons are the norm rather than the exception in astrophysical processes that involve stellar-scale black holes.

  13. STS-86 Pilot Michael Bloomfield suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-86 Pilot Michael J. Bloomfield relaxes for a moment while donning his launch and entry suit with the assistance of a suit technician in the Operations and Checkout Building. This will be Bloomfields first spaceflight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff on a 10-day mission slated to be the seventh docking of the Space Shuttle with the Russian Space Station Mir.

  14. New Horizons at Jupiter

    NASA Astrophysics Data System (ADS)

    Stern, S. Alan

    2007-12-01

    New Horizons is NASA's reconnaissance mission to explore the Pluto system and small Kuiper Belt Objects (KBOs). I will describe the mission's history, current status, and instrument suite. I will then describe the Jupiter gravity assist flyby New Horizons conducted in early-mid 2007. This flyby involved over 700 observations in the Jupiter system, and represents the only spacecraft encounter with Jupiter planned to occur between the demise of Galileo in 2003 and the arrival of Juno in 2016. I will focus on results obtained, including the first-ever exploration of a giant planet magnetotail, new compositional observations of icy Galilean satellites, exploration of Jupiter's tenuous ring system, the first high-resolution spacecraft imagery of Jupiter's newly-generated little red spot, and the first-ever time-lapse imagery of an Ionian volcano eruption.

  15. Refraction near the horizon

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.; Liller, William

    1990-01-01

    Variations in astronomical refraction near the horizon are examined. Sunset timings, a sextant mounted on a tripod, and a temperature profile are utilized to derive the variations in refraction data, collected from 7 locations. It is determined that the refraction ranges from 0.234 to 1.678 deg with an rms deviation of 0.16, and it is observed that the variation is larger than previously supposed. Some applications for the variation of refraction value are discussed.

  16. A rapid whole genome sequencing and analysis system supporting genomic epidemiology (7th Annual SFAF Meeting, 2012)

    SciTech Connect

    FitzGerald, Michael

    2012-06-01

    Michael FitzGerald on "A rapid whole genome sequencing and analysis system supporting genomic epidemiology" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  17. A rapid whole genome sequencing and analysis system supporting genomic epidemiology (7th Annual SFAF Meeting, 2012)

    ScienceCinema

    FitzGerald, Michael [Broad Institute

    2016-07-12

    Michael FitzGerald on "A rapid whole genome sequencing and analysis system supporting genomic epidemiology" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  18. Obituary: Michael James Ledlow, 1964-2004

    NASA Astrophysics Data System (ADS)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  19. New Horizons at Pluto

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Artist's concept of the New Horizons spacecraft as it approaches Pluto and its largest moon, Charon, in July 2015. The craft's miniature cameras, radio science experiment, ultraviolet and infrared spectrometers and space plasma experiments will characterize the global geology and geomorphology of Pluto and Charon, map their surface compositions and temperatures, and examine Pluto's atmosphere in detail. The spacecraft's most prominent design feature is a nearly 7-foot (2.1-meter) dish antenna, through which it will communicate with Earth from as far as 4.7 billion miles (7.5 billion kilometers) away.

  20. Entropy of isolated horizons revisited

    SciTech Connect

    Basu, Rudranil; Kaul, Romesh K.; Majumdar, Parthasarathi

    2010-07-15

    The decade-old formulation of the isolated horizon classically and within loop quantum gravity, and the extraction of the microcanonical entropy of such a horizon from this formulation, is reviewed, in view of recent renewed interest. There are two main approaches to this problem: one employs an SU(2) Chern-Simons theory describing the isolated horizon degrees of freedom, while the other uses a reduced U(1) Chern-Simons theory obtained from the SU(2) theory, with appropriate constraints imposed on the spectrum of boundary states ''living'' on the horizon. It is shown that both these ways lead to the same infinite series asymptotic in the horizon area for the microcanonical entropy of an isolated horizon. The leading area term is followed by an unambiguous correction term logarithmic in area with a coefficient -(3/2), with subleading corrections dropping off as inverse powers of the area.

  1. HORIZON SENSING (PROPOSAL NO.51)

    SciTech Connect

    Larry G. Stolarczyk

    2003-07-01

    Real-time horizon sensing on continuous mining machines is becoming an industry tool. Installation and testing of production-grade Horizon Sensor (HS) systems continued this quarter at Monterey Coal Company (ExxonMobil), Mountain Coal Company West Elk Mine (Arch), and Ohio Valley Coal Company (OVC). Monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  2. HORIZON SENSING (PROPOSAL NO.51)

    SciTech Connect

    Larry G. Stolarczyk

    2003-07-30

    Real-time horizon sensing on continuous mining (CM) machines is becoming an industry tool. Installation and testing of production-grade Horizon Sensor (HS) systems has been ongoing this quarter at Monterey Coal Company (ExxonMobil), Mountain Coal Company West Elk Mine (Arch), Deserado Mining Company (Blue Mountain Energy), and The Ohio Valley Coal Company (TOVCC). Monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  3. Transverse deformations of extreme horizons

    NASA Astrophysics Data System (ADS)

    Li, Carmen; Lucietti, James

    2016-04-01

    We consider the inverse problem of determining all extreme black hole solutions to the Einstein equations with a prescribed near-horizon geometry. We investigate this problem by considering infinitesimal deformations of the near-horizon geometry along transverse null geodesics. We show that, up to a gauge transformation, the linearised Einstein equations reduce to an elliptic PDE for the extrinsic curvature of a cross-section of the horizon. We deduce that for a given near-horizon geometry there exists a finite dimensional moduli space of infinitesimal transverse deformations. We then establish a uniqueness theorem for transverse deformations of the extreme Kerr horizon. In particular, we prove that the only smooth axisymmetric transverse deformation of the near-horizon geometry of extreme Kerr, such that cross-sections of the horizon are marginally trapped surfaces, corresponds to that of the extreme Kerr black hole. Furthermore, we determine all smooth and biaxisymmetric transverse deformations of the near-horizon geometry of the five-dimensional extreme Myers-Perry black hole with equal angular momenta. We find a three parameter family of solutions such that cross-sections of the horizon are marginally trapped, which is more general than the known black hole solutions. We discuss the possibility that they correspond to new five-dimensional vacuum black holes.

  4. Michael Faraday and his contribution to anesthesia.

    PubMed

    Bergman, N A

    1992-10-01

    Michael Faraday (1791-1867) was a protégé of Humphry Davy. He became one of Davy's successors as Professor of Chemistry at the Royal Institution of Great Britain. Of Faraday's many brilliant discoveries in chemistry and physics, probably the best remembered today is his work on electromagnetic induction. Faraday's contribution to introduction of anesthesia was his published announcement in 1818 that inhalation of the vapor of ether produced the same effects on mentation and consciousness as the breathing of nitrous oxide. He most likely became familiar with the central nervous system effects of nitrous oxide through his association with Davy, an avid user of the gas. Sulfuric ether was a common, convenient, cheap, and easily available substance, in contrast to nitrous oxide, which required expensive, cumbersome, and probably not widely available apparatus for its production and administration. The capability for inhaling intoxicating vapors eventually became commonly available with the use of ether instead of the gas. The first surgical anesthetics were a consequence of the resulting student "ether frolics." The 1818 announcement on breathing ether vapor was published anonymously; however, notations in Faraday's handwriting in some of his personal books clearly establish Michael Faraday as the author of this brief communication. PMID:1416178

  5. Michael Faraday and his contribution to anesthesia.

    PubMed

    Bergman, N A

    1992-10-01

    Michael Faraday (1791-1867) was a protégé of Humphry Davy. He became one of Davy's successors as Professor of Chemistry at the Royal Institution of Great Britain. Of Faraday's many brilliant discoveries in chemistry and physics, probably the best remembered today is his work on electromagnetic induction. Faraday's contribution to introduction of anesthesia was his published announcement in 1818 that inhalation of the vapor of ether produced the same effects on mentation and consciousness as the breathing of nitrous oxide. He most likely became familiar with the central nervous system effects of nitrous oxide through his association with Davy, an avid user of the gas. Sulfuric ether was a common, convenient, cheap, and easily available substance, in contrast to nitrous oxide, which required expensive, cumbersome, and probably not widely available apparatus for its production and administration. The capability for inhaling intoxicating vapors eventually became commonly available with the use of ether instead of the gas. The first surgical anesthetics were a consequence of the resulting student "ether frolics." The 1818 announcement on breathing ether vapor was published anonymously; however, notations in Faraday's handwriting in some of his personal books clearly establish Michael Faraday as the author of this brief communication.

  6. Technologies on the Horizon: Teachers Respond to the Horizon Report

    ERIC Educational Resources Information Center

    Hodges, Charles B.; Prater, Alyssa H.

    2014-01-01

    The purpose of this study was to investigate teachers' beliefs regarding the integration of technologies from the 2011 K-12 edition of the "Horizon Report" into their local, public school contexts. Teachers read the "Horizon Report" and then participated in an asynchronous, threaded discussion focusing on technologies they…

  7. Resolving Lifshitz Horizons

    SciTech Connect

    Harrison, Sarah; Kachru, Shamit; Wang, Huajia; /Stanford U., ITP /Stanford U., Phys. Dept. /SLAC

    2012-04-24

    Via the AdS/CFT correspondence, ground states of field theories at finite charge density are mapped to extremal black brane solutions. Studies of simple gravity + matter systems in this context have uncovered wide new classes of extremal geometries. The Lifshitz metrics characterizing field theories with non-trivial dynamical critical exponent z {ne} 1 emerge as one common endpoint in doped holographic toy models. However, the Lifshitz horizon exhibits mildly singular behaviour - while curvature invariants are finite, there are diverging tidal forces. Here we show that in some of the simplest contexts where Lifshitz metrics emerge, Einstein-Maxwell-dilaton theories, generic corrections lead to a replacement of the Lifshitz metric, in the deep infrared, by a re-emergent AdS{sub 2} x R{sup 2} geometry. Thus, at least in these cases, the Lifshitz scaling characterizes the physics over a wide range of energy scales, but the mild singularity is cured by quantum or stringy effects.

  8. Organocatalytic enantioselective Michael-Michael-Michael-aldol condensation reactions: control of five stereocenters in a quadruple-cascade asymmetric synthesis of highly functionalized hexahydrophenanthrenes.

    PubMed

    Raja, Arun; Hong, Bor-Cherng; Lee, Gene-Hsiang

    2014-11-01

    A cascade organocatalysis has been developed for the enantioselective synthesis of a highly functionalized hexahydrophenanthrene-2-carbaldehyde containing five contiguous stereogenic centers with high diastereoselectivity and high enantioselectivity (>99% ee). The one-pot method comprises a cascade of organocatalytic Michael-Michael-Michael-aldol reactions of 2-methyl-1,5-dinitro-3-((E)-2-nitrovinyl)benzene and α,β-unsaturated aldehydes (e.g., cinnamaldehyde). The structure and absolute configuration of a product were confirmed by X-ray analysis of an appropriate derivative.

  9. The Horizon Report. 2005 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2005

    2005-01-01

    This second edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series…

  10. The Horizon Report. 2006 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2006

    2006-01-01

    This third edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing discussions…

  11. The Horizon Report. 2004 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2004

    2004-01-01

    This first edition of the New Media Consortium's (NMC) annual "Horizon Report" details findings of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series of interviews…

  12. Language and Intercultural Education: An Interview with Michael Byram

    ERIC Educational Resources Information Center

    Porto, Melina

    2013-01-01

    This article reports an interview with Michael Byram, Professor Emeritus, University of Durham in the United Kingdom, during his visit to Argentina in September 2011. Michael Byram is one of the main international referents in intercultural education. The interview addresses issues such as language education, intercultural and citizenship…

  13. Doing It All: Michael Sullivan--Weeks Public Library, NH

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Michael Sullivan is a juggler--not a metaphorical one, a real one. He's also a library director, storyteller, competitive chess player, poet, speaker, and former children's librarian who continues to work with the kids in his community. This article summarizes the accomplishments and work of Michael Sullivan.

  14. 76 FR 10352 - Keyser, Michael J.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Keyser, Michael J.; Notice of Filing Take notice that on February 15, 2011, Michael J. Keyser submitted for filing, an application for authority to hold interlocking...

  15. Michael J. Meaney: Award for Distinguished Scientific Contributions

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…

  16. Michael Young and the Curriculum Field in South Africa

    ERIC Educational Resources Information Center

    Hoadley, Ursula

    2015-01-01

    The paper addresses the question of what we should make of Michael Young's recent work with respect to curriculum theory by considering the particular case of South African curriculum reform. The paper thus traces two trajectories: the evolution of Michael Young's ideas over time and South African curriculum reform in the post-apartheid period.…

  17. Michael Naranjo, The Story of an American Indian.

    ERIC Educational Resources Information Center

    Nelson, Mary Carroll

    Michael Naranjo is a Pueblo Indian who, after much searching, has become a talented sculptor. The son of a Baptist minister, Michael grew up observing nature and exploring the countryside around Santa Clara (New Mexico), his birthplace. When he was nine, his family moved to Taos, where he watched the ceremonies of the Taos Pueblos with…

  18. Michael Faraday's Contributions to Archaeological Chemistry.

    PubMed

    Moshenska, Gabriel

    2015-08-01

    The analysis of ancient artefacts is a long but largely neglected thread within the histories of archaeology and chemistry. This paper examines Michael Faraday's contributions to this nascent field, drawing on his published correspondence and the works of his antiquarian collaborators, and focusing in particular on his analyses of Romano-British and ancient Egyptian artefacts. Faraday examined the materials used in ancient Egyptian mummification, and provided the first proof of the use of lead glazes on Roman ceramics. Beginning with an assessment of Faraday's personal interests and early work on antiquities with Humphry Davy, this paper critically examines the historiography of archaeological chemistry and attempts to place Faraday's work within its institutional, intellectual, and economic contexts. PMID:26307911

  19. Michael Maier--nine newly discovered letters.

    PubMed

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony. PMID:25241502

  20. Michael Faraday's Contributions to Archaeological Chemistry.

    PubMed

    Moshenska, Gabriel

    2015-08-01

    The analysis of ancient artefacts is a long but largely neglected thread within the histories of archaeology and chemistry. This paper examines Michael Faraday's contributions to this nascent field, drawing on his published correspondence and the works of his antiquarian collaborators, and focusing in particular on his analyses of Romano-British and ancient Egyptian artefacts. Faraday examined the materials used in ancient Egyptian mummification, and provided the first proof of the use of lead glazes on Roman ceramics. Beginning with an assessment of Faraday's personal interests and early work on antiquities with Humphry Davy, this paper critically examines the historiography of archaeological chemistry and attempts to place Faraday's work within its institutional, intellectual, and economic contexts.

  1. Michael Maier--nine newly discovered letters.

    PubMed

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  2. STS-97 Crew Interviews: Michael J. Bloomfield

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Live footage of a preflight interview with Pilot Michael J. Bloomfield is shown. The interview addresses many different questions including why Bloomfield became interested in the space program, the events and people that influence him and ultimately led to his interest, and his vigorous training in the astronaut program. Other interesting information that this one-on-one interview discusses are the main goals of the STS-97 mission, its scheduled docking with the new International Space Station (ISS), and its delivery of the first set of U.S.-provided solar arrays, batteries, and radiators. Bloomfield briefly discusses his responsibilities during the much-anticipated docking as well as during the scheduled space-walks.

  3. STS-109 Crew Interviews: Michael J. Massimino

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-109 Mission Specialist Michael J. Massimino is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, and his most memorable experiences. He gives details on the mission's goals and objectives, which focus on the refurbishing of the Hubble Space Telescope, and his role in the mission. He explains the plans for the rendezvous of the Columbia Orbiter with the Hubble Space Telescope. He provides details and timelines for each of the planned Extravehicular Activities (EVAs), which include replacing the solar arrays, changing the Power Control Unit, installing the Advanced Camera for Surveys (ACS), and installing a new Cryocooler for the Near Infrared Camera and Multi-Object Spectrometer (NICMOS). He also describes the break-out plan in place for these spacewalks. The interview ends with Massimino explaining the details of a late addition to the mission's tasks, which is to replace a reaction wheel on the Hubble Space Telescope.

  4. Social Pharmacology: Expanding horizons

    PubMed Central

    Maiti, Rituparna; Alloza, José Luis

    2014-01-01

    In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so-called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far-reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of therapy, while minimizing negative social consequences. PMID:24987168

  5. Mechanics of rotating isolated horizons

    SciTech Connect

    Ashtekar, Abhay; Beetle, Christopher; Lewandowski, Jerzy

    2001-08-15

    Black hole mechanics was recently extended by replacing the more commonly used event horizons in stationary space-times with isolated horizons in more general space-times (which may admit radiation arbitrarily close to black holes). However, so far the detailed analysis has been restricted to nonrotating black holes (although it incorporated arbitrary distortion, as well as electromagnetic, Yang-Mills, and dilatonic charges). We now fill this gap by first introducing the notion of isolated horizon angular momentum and then extending the first law to the rotating case.

  6. HORIZON SENSING (PROPOSAL No.51)

    SciTech Connect

    Larry G. Stolarczyk, Sc.D.

    2002-04-30

    Real-time horizon sensing on continuous mining machines is becoming an industry tool. Installation and testing of production-grade HS systems has been ongoing this quarter at Monterey Coal Company (EXXON), FMC Trona, Twentymile Coal Company (RAG America), and SASOL Coal. Detailed monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  7. Two papers by Michael Fordham (d.1995).

    PubMed

    Astor, James

    2010-11-01

    The Journal has decided to publish a selection of previously unpublished papers from the Michael Fordham archives, which are being prepared for publication by James Astor and Elizabeth Urban, and of which the two papers published here are the first, both dating from the 1950s. 'Analyst and Priest' seems to be addressed to an audience of mainly religious people who are interested in the relation between psychology and religion and to whom Fordham is introducing some basic Jungian concepts and ways of thinking. The analyst in this lecture is the advocate of a new science, the priest an established figure with a role in society and rituals to perform. As the paper progresses he refines the differences between priest and analyst in terms of individual development versus a philosophy of life. The paper ends with a plea for co-operation between priest and analyst. 'Analyst and Scientist' was a radio talk given in 1956. In this paper Fordham makes the case for paying attention to the irrational. He draws support from Pauli and Polanyi. His theme is to show the scientific value of the subjective. From this he describes the scientific basis for Jung's comparative method and consequently of archetypal psychology.

  8. Obituary: Michael John Klein, 1940-2005

    NASA Astrophysics Data System (ADS)

    Gulkis, Samuel

    2006-12-01

    Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

  9. Two papers by Michael Fordham (d.1995).

    PubMed

    Astor, James

    2010-11-01

    The Journal has decided to publish a selection of previously unpublished papers from the Michael Fordham archives, which are being prepared for publication by James Astor and Elizabeth Urban, and of which the two papers published here are the first, both dating from the 1950s. 'Analyst and Priest' seems to be addressed to an audience of mainly religious people who are interested in the relation between psychology and religion and to whom Fordham is introducing some basic Jungian concepts and ways of thinking. The analyst in this lecture is the advocate of a new science, the priest an established figure with a role in society and rituals to perform. As the paper progresses he refines the differences between priest and analyst in terms of individual development versus a philosophy of life. The paper ends with a plea for co-operation between priest and analyst. 'Analyst and Scientist' was a radio talk given in 1956. In this paper Fordham makes the case for paying attention to the irrational. He draws support from Pauli and Polanyi. His theme is to show the scientific value of the subjective. From this he describes the scientific basis for Jung's comparative method and consequently of archetypal psychology. PMID:20961314

  10. Race, punishment, and the Michael Vick experience.

    PubMed

    Piquero, Alex R; Piquero, Nicole Leeper; Gertz, Marc; Baker, Thomas; Batton, Jason; Barnes, J C

    2011-01-01

    Objective. The relationship between race and crime has been contentious, focusing primarily on offending and incarceration patterns among minorities. There has been some limited work on public perceptions of criminal punishment, and findings show that while minorities believe in the role and rule of law, they simultaneously perceive the justice system as acting in a biased and/or unfair manner. Two limitations have stalled this literature. First, research has focused mainly on criminal punishments to the neglect of noncriminal punishments. Second, most studies have not examined whether race remains salient after considering other demographic variables or discrimination and legitimacy attitudes.Methods. Using data from 400 adults, we examine how race affects perceptions of criminal punishment and subsequent reinstatement into the National Football League in the case of Michael Vick, a star professional quarterback who pled guilty to charges of operating an illegal dog-fighting ring.Results. Findings show that whites are more likely to view Vick's punishment as too soft and that he should not be reinstated, while nonwhites had the opposite views. Race remained significant after controlling for other variables believed to be related to punishment perceptions.Conclusion. Attitudes toward both criminal punishment and NFL reinstatement vary across race such that there exists important divides in how individuals perceive the system meting out punishment and subsequently reintegrating offenders back into society. These results underscore that white and nonwhites perceive the law and its administration differently.

  11. Satellite Sees Hurricane Leslie and Tropical Storm Michael in Atlantic

    NASA Video Gallery

    A movie of satellite observations from Sept. 2-5, 2012, shows Leslie strengthen into a Hurricane on September 5 as it nears Bermuda, and tiny Tropical Storm Michael in the central Atlantic Ocean. T...

  12. Astronaut Michael Foale on RMS arm during EVA

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Astronaut C. Michael Foale (red stripe), mission specialist, on the Remote Manipulator System (RMS) arm prepares to grab SPARTAN 204 as astronaut Bernard A. Harris Jr., payload commander, looks on during the STS-63 extravehicular activity (EVA).

  13. STS-107 M.S Michael Anderson at SPACEHAB

    NASA Technical Reports Server (NTRS)

    2000-01-01

    KENNEDY SPACE CENTER, FLA. -- At SPACEHAB, STS-107 Mission Specialist Michael Anderson (gloved, in center) gets hands-on experience with equipment. Identified as a research mission, STS-107 is scheduled for launch July 19, 2001

  14. Michael López-Alegría Profile

    NASA Video Gallery

    Meet NASA astronaut Michael López-Alegría, a veteran of four spaceflights. He has logged over 257 days in space and performed 10 spacewalks. Learn what inspired him to become such a successful astr...

  15. Deepwater Horizon Situation Report #5

    SciTech Connect

    2010-06-10

    At approximately 11:00 pm EDT April 20, 2010 an explosion occurred aboard the Deepwater Horizon mobile offshore drilling unit (MODU) located 52 miles Southeast of Venice, LA and 130 miles southeast of New Orleans, LA. The MODU was drilling an exploratory well and was not producing oil at the time of the incident. The Deepwater Horizon MODU sank 1,500 feet northwest of the well site. Detailed information on response and recovery operations can be found at: http://www.deepwaterhorizonresponse.com/go/site/2931/

  16. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  17. Common Ground: Expanding Our Horizons.

    ERIC Educational Resources Information Center

    McDevitt, Michele J.

    In "Common Ground: Dialogue, Understanding, and the Teaching of Composition," Kurt Spellmeyer seeks to familiarize students and teachers with the linguistic and cultural no-man's-land separating them. Reinstating the value of two writing conventions often used by traditional students--expressive and commonplaces--can help expand on the horizons of…

  18. NIF featured on BBC "Horizon"

    ScienceCinema

    Brian Cox

    2016-07-12

    The National Ignition Facility, the world's largest laser system, located at Lawrence Livermore National Laboratory, was featured in the BBC broadcast "Horizon" hosted by physicist Brian Cox. Here is the NIF portion of the program, which was entitled "Can We Make A Star On Earth?" This video is used with the express permission of the BBC.

  19. New Horizons Mission to Pluto

    NASA Technical Reports Server (NTRS)

    Delgado, Luis G.

    2011-01-01

    This slide presentation reviews the trajectory that will take the New Horizons Mission to Pluto. Included are photographs of the spacecraft, the launch vehicle, the assembled vehicle as it is being moved to the launch pad and the launch. Also shown are diagrams of the assembled parts with identifying part names.

  20. New Horizons in Education, 2000.

    ERIC Educational Resources Information Center

    Ho, Kwok Keung, Ed.

    2000-01-01

    This document contains the May and November 2000 issues of "New Horizons in Education," with articles in English and Chinese. The May issue includes the following articles: "A Key to Successful Environmental Education: Teacher Trainees' Attitude, Behaviour, and Knowledge" (Kevin Chung Wai Lui, Eric Po Keung Tsang, Sing Lai Chan); "Critical…

  1. NIF featured on BBC "Horizon"

    SciTech Connect

    Brian Cox

    2010-01-12

    The National Ignition Facility, the world's largest laser system, located at Lawrence Livermore National Laboratory, was featured in the BBC broadcast "Horizon" hosted by physicist Brian Cox. Here is the NIF portion of the program, which was entitled "Can We Make A Star On Earth?" This video is used with the express permission of the BBC.

  2. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  3. The Malcolm horizon: History and future

    NASA Technical Reports Server (NTRS)

    Malcolm, R.

    1984-01-01

    The development of the Malcolm Horizon, a peripheral vision horizon used in flight simulation, is discussed. A history of the horizon display is presented as well as a brief overview of vision physiology, and the role balance plays is spatial orientation. Avenues of continued research in subconscious cockpit instrumentation are examined.

  4. Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?

    PubMed Central

    2014-01-01

    The Michael hydratase – alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a spectrophotometric assay and an activity staining in a native gel of the dehydrogenase. New insights in the recently discovered organocatalytic Michael addition of water led to the conclusion that the previously performed experiments to identify MhyADH as a bi-functional enzyme and their results need to be reconsidered and the reliability of the methodology used needs to be critically evaluated. PMID:24949265

  5. Lipase-catalyzed aza-Michael reaction on acrylate derivatives.

    PubMed

    Steunenberg, Peter; Sijm, Maarten; Zuilhof, Han; Sanders, Johan P M; Scott, Elinor L; Franssen, Maurice C R

    2013-04-19

    A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas stutzeri lipase and Chromobacterium viscosum lipase showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates. For the first time also, some CLEAs were examined that showed a comparable or higher selectivity and yield than the free enzymes and other formulations.

  6. Fermion tunneling from dynamical horizons

    NASA Astrophysics Data System (ADS)

    Di Criscienzo, R.; Vanzo, L.

    2008-06-01

    The instability against emission of fermionic particles by the trapping horizon of an evolving black hole is analyzed and confirmed using the Hamilton-Jacobi tunneling method. This method automatically selects one special expression for the surface gravity of a changing horizon. The results also apply to point masses embedded in an expanding universe. As a bonus of the tunneling method, we gain the insight that the surface gravity still defines a temperature parameter as long as the evolution is sufficiently slow that the black-hole pass through a sequence of quasi-equilibrium states, and that black holes should be semi-classically unstable even in a hypothetical world without bosonic fields.

  7. Obituary: Michael John Seaton, 1923-2007

    NASA Astrophysics Data System (ADS)

    Pradhan, Anil; Nahar, Sultana

    2007-12-01

    Professor Michael John Seaton, hailed as the "Father of Atomic Astrophysics," passed away on May 29, 2007. He was one of the few Honorary Fellows of both the American Astronomical Society and the American Physical Society, so honored for his monumental contributions to both physics and astronomy. Mike Seaton was born on January 16, 1923 in Bristol, England. He attended Wallington County High School. But his leftist political activities, even at that stage, led to his expulsion, though he was eventually allowed to matriculate. He enlisted in the Royal Air Force as a navigator during the Second World War, and flew many dangerous missions. His legendary concentration and precision are reflected in the following anecdote. Once after a bombing mission his aircraft was lost in fog over the Alps. Seaton calculated the position and coordinates in flight to guide the aircraft. When the fog lifted, the crew found themselves flying perilously close to the mountains, but made it safely back. His associates often said, "A Seaton calculation is carried out as if his life depended on it." After the War he was admitted to University College London (UCL) as an undergraduate. Thereafter, he spent all of his professional career at UCL. Seaton received his Batchelor's degree in 1948, and his Ph.D. in 1951. His tenure at UCL coincided with the golden age of atomic astrophysics, for he was largely responsible for it. Seaton was elected Fellow of the Royal Society in 1967, and as President of the Royal Astronomical Society (RAS) in 1978. He was the recipient of an Honorary Doctorate from the Observatoire de Paris, an Honorary D.Sc. from the Queen's University of Belfast, the Gold Medal for Astronomy by the RAS, the Guthrie Medal by the Institute of Physics, the Royal Society Hughes award for lifetime work by the RAS, and several other prestigious awards. Nevertheless, as Alex Dalgarno recently remarked, Seaton was not part of the establishment because he chose not to be. Though rooted in

  8. Penrose inequality and apparent horizons

    SciTech Connect

    Ben-Dov, Ishai

    2004-12-15

    A spherically symmetric spacetime is presented with an initial data set that is asymptotically flat, satisfies the dominant energy condition, and such that on this initial data M<{radical}(A/16{pi}), where M is the total mass and A is the area of the apparent horizon. This provides a counterexample to a commonly stated version of the Penrose inequality, though it does not contradict the true Penrose inequality.

  9. Toroidal horizons in binary black hole mergers

    NASA Astrophysics Data System (ADS)

    Bohn, Andy; Kidder, Lawrence E.; Teukolsky, Saul A.

    2016-09-01

    We find the first binary black hole event horizon with a toroidal topology. It has been predicted that generically the event horizons of merging black holes should briefly have a toroidal topology. However, such a phase has never been seen in numerical simulations. Instead, in all previous simulations, the topology of the event horizon transitions directly from two spheres during the inspiral to a single sphere as the black holes merge. We find a coordinate transformation to a foliation of spacelike hypersurfaces that "cut a hole" through the event horizon surface, resulting in a toroidal event horizon, thus reconciling the numerical work with theoretical expectations. The demonstration requires extremely high numerical precision, which is made possible by a new event horizon code described in a companion paper. A torus could potentially provide a mechanism for violating topological censorship. However, these toroidal event horizons satisfy topological censorship by construction, because we can always trivially apply the inverse coordinate transformation to remove the topological feature.

  10. New Horizons Launch Contingency Effort

    NASA Astrophysics Data System (ADS)

    Chang, Yale; Lear, Matthew H.; McGrath, Brian E.; Heyler, Gene A.; Takashima, Naruhisa; Owings, W. Donald

    2007-01-01

    On 19 January 2006 at 2:00 PM EST, the NASA New Horizons spacecraft (SC) was launched from the Cape Canaveral Air Force Station (CCAFS), FL, onboard an Atlas V 551/Centaur/STAR™ 48B launch vehicle (LV) on a mission to explore the Pluto Charon planetary system and possibly other Kuiper Belt Objects. It carried a single Radioisotope Thermoelectric Generator (RTG). As part of the joint NASA/US Department of Energy (DOE) safety effort, contingency plans were prepared to address the unlikely events of launch accidents leading to a near-pad impact, a suborbital reentry, an orbital reentry, or a heliocentric orbit. As the implementing organization. The Johns Hopkins University Applied Physics Laboratory (JHU/APL) had expanded roles in the New Horizons launch contingency effort over those for the Cassini mission and Mars Exploration Rovers missions. The expanded tasks included participation in the Radiological Control Center (RADCC) at the Kennedy Space Center (KSC), preparation of contingency plans, coordination of space tracking assets, improved aerodynamics characterization of the RTG's 18 General Purpose Heat Source (GPHS) modules, and development of spacecraft and RTG reentry breakup analysis tools. Other JHU/APL tasks were prediction of the Earth impact footprints (ElFs) for the GPHS modules released during the atmospheric reentry (for purposes of notification and recovery), prediction of the time of SC reentry from a potential orbital decay, pre-launch dissemination of ballistic coefficients of various possible reentry configurations, and launch support of an Emergency Operations Center (EOC) on the JHU/APL campus. For the New Horizons launch, JHU/APL personnel at the RADCC and at the EOC were ready to implement any real-time launch contingency activities. A successful New Horizons launch and interplanetary injection precluded any further contingency actions. The New Horizons launch contingency was an interagency effort by several organizations. This paper

  11. Michael Polanyi on the Education and Knowledge of Scientists.

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2000-01-01

    Explains why teachers addressing the nature of science should know the work of Michael Polanyi. Outlines Polanyi's intellectual career and examines his ideas on the education of scientists, research, and knowledge. Polanyi presaged Kuhn, Feyerabend, and the constructivists, yet insisted that science produces true knowledge about reality. (Contains…

  12. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  13. The Holocaust and Education: An Interview with Michael Berenbaum.

    ERIC Educational Resources Information Center

    Goldberg, Mark

    1997-01-01

    In January 1997, Michael Berenbaum became president and chief executive officer of Survivors of the Shoah Visual History Foundation, the organization established by filmmaker Steven Spielberg after completing "Schindler's List." Since 1994, the foundation has been recording eyewitness testimony on the Holocaust. Berenbaum's mandate is to share…

  14. Writing before the Letter: Reading Michael Ondaatje's "Handwriting"

    ERIC Educational Resources Information Center

    Festino, Cielo G.

    2006-01-01

    The purpose of this paper is to offer a reading of "Handwriting", the book of poems by the Canadian-Sri Lankan author, Michael Ondaatje, in which he recovers the recent and ancient cultural history of the island through his reading of different types of scripts and languages. The texts that Ondaatje rewrites in his poems are visual, written, oral…

  15. Reading Michael Apple--The Sociological Imagination at Work

    ERIC Educational Resources Information Center

    Ball, Stephen J.

    2007-01-01

    This article discusses Michael Apple's contribution to the sociology of education and education policy analysis and the politics of education. It focuses on ways of "reading" Apple as an intellectual and an activist and looks at the trajectory of his work over a long and illustrious career.

  16. HEADSTONES OF BERNARD AND MICHAEL JODD, FATHERANDSON CIVILIANS RESPONSIBLE FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HEADSTONES OF BERNARD AND MICHAEL JODD, FATHER-AND-SON CIVILIANS RESPONSIBLE FOR CONSTRUCTION OF BRICK PERIMETER WALL WHO DIED OF YELLOW FEVER DURING WALL CONSTRUCTION. VIEW TO WEST. - Baton Rouge National Cemetery, 220 North 19th Street, Baton Rouge, East Baton Rouge Parish, LA

  17. Michael Stipe Wake-Up Song and Greeting

    NASA Video Gallery

    The four astronauts of the final space shuttle mission are greeted by R.E.M. front man Michael Stipe and the group’s hit, "Man on the Moon" to begin Flight Day 7. On recording this song for the A...

  18. Major Michael J. Colburn: A Passion for Music Shapes Lives

    ERIC Educational Resources Information Center

    Colburn, Michael J.

    2004-01-01

    This article is adapted from a speech given by Major Michael J. Colburn executive officer and senior assistant director of the United States Marine Band, to the MENC Summer Leadership Conference July 12-15, 2003 at the MENC national headquarters in Reston, Virginia. In this article, Colburn shares three personal anecdotes that he considers to be…

  19. What Works, Works Everywhere: Q&A with Michael Barber

    ERIC Educational Resources Information Center

    Crow, Tracy

    2009-01-01

    This article presents an interview with Michael Barber, a partner at McKinsey & Company, leading its global education practice. He has been working on major challenges of performance, organization, and reform in government and the public services, especially education, in the U.S., U.K., and other countries. Barber was instrumental in preparing…

  20. Perfil de Michael López- Alegría

    NASA Video Gallery

    Conoce al astronauta de la NASA Michael López-Alegría, veterano de cuatro vuelos espaciales. Lleva registrados 257 días en el espacio y llevó a cabo 10 paseos espaciales. Conoce lo que lo inspiró a...

  1. "No More Excuses": Michael M. Crow on Analytics

    ERIC Educational Resources Information Center

    Crow, Michael M.

    2012-01-01

    Michael M. Crow became the 16th president of Arizona State University in July 2002, with the goal of transforming ASU into what he calls a "New American University"--an institution combining the highest levels of academic excellence, inclusiveness to a broad demographic, and maximum societal impact. His view included increasing graduate numbers,…

  2. Michael Polanyi: The University and the Technological State.

    ERIC Educational Resources Information Center

    Price, G. L.

    1978-01-01

    The problem of the intellectual independence of the university within a technologically oriented society was one of the problems which motivated Michael Polanyi's inquiry into the foundations of knowledge. The key elements of his resultant attempt to supersede objectivist accounts of science are isolated, and evaluated. (Editor/RK)

  3. The Epistemic Criterion: A Response to Michael Hand

    ERIC Educational Resources Information Center

    Cooling, Trevor

    2014-01-01

    This article is a response to Michael Hand's critique in this issue of my response to his use of the epistemic criterion as the sole means for identifying whether or not an issue should be identified as controversial. I argue that he has misunderstood my intention in suggesting that I was seeking to replace the epistemic criterion. Rather my…

  4. Michael Young, Knowledge and Curriculum: An International Dialogue

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2015-01-01

    This issue of the "Journal of Curriculum Studies" presents a symposium on the recent work of Michael Young. Contemporary curriculum theory has little specific to say about how knowledge is selected, organized and transformed into curriculum content for teaching and learning. Over the last two decades, Young has taken a rather different…

  5. A Good Time: A Conversation with C. Michael Nelson

    ERIC Educational Resources Information Center

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  6. Michael Young and the Politics of the School Curriculum

    ERIC Educational Resources Information Center

    Morgan, John

    2015-01-01

    Michael Young's work is central to debates about knowledge and the school curriculum. In recent years he has renounced his early argument that school subjects represent the "knowledge of the powerful", arguing instead that access and equality for all students are dependent on ensuring that all get access to "powerful…

  7. STS-73 MS Michael E. Lopez-Alegria suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-73 Mission Specialist Michael E. Lopez-Alegria is donning his launch/entry suit in the Operations and Checkout Building. The seven-member crew of Mission STS-73 will depart shortly for Launch Pad 39B, where the Space Shuttle Columbia awaits another liftoff attempt at 9:50 a.m. EDT.

  8. Insight into the Mechanism of the Michael Reaction.

    PubMed

    Giraldo, Carolina; Gómez, Sara; Weinhold, Frank; Restrepo, Albeiro

    2016-07-01

    The mechanism for the nucleophilic addition step of the Michael reaction between methanethiol as a model Michael donor and several α-substituted methyl acrylates (X=F, Cl, Me, H, CN, NO2 ) as model Michael acceptors is described in detail. We suggest a novel way to condense electrophilic Fukui functions at specific atoms in terms of the contributions from the atomic orbitals to the LUMO or, more generally, to the orbital controlling the reaction. This procedure correctly associates activation energies to local electrophilic Fukui indices for the cases treated in this work. The calculated reaction barriers strongly depend on the nature of the substituent. As a general rule, activation energies are governed by structural changes, although electronic factors are significant for electron-withdrawing groups. Nucleophilic addition to Michael receptors is best described as a highly nonsynchronous process, in which the geometry of the transition state comprises a nonplanar six-membered ring. Formation of the S⋅⋅⋅C bond, which defines the interaction between the reactants, progresses ahead of all other primitive processes in the early stages of the transformation. In view of our results, we postulate that highly complex chemical reactions, as is the case for the nucleophilic addition step studied herein, that involve cleavage/formation of a total of six bonds, lower their activation energies by favoring nonsynchronicity, that is, for these types of systems, primitive changes should advance at different rates.

  9. Astronaut Michael Clifford takes a break during bailout training

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut Michael R.U. (Rich) Clifford takes a break while video taping crew mates in training in the JSC Weightless Environment Training Facility (WETF). He is pictured with Trent G. Keeple, a member of the training staff assigned to STS-59.

  10. Educational Implications of Michael Fishbane's "Sacred Attunement: A Jewish Theology"

    ERIC Educational Resources Information Center

    Marom, Daniel

    2008-01-01

    This article posits Michael Fishbane's Judaic scholarship as a prime resource for Jewish education. The link between the two fields can be made through a translation of the theological underpinnings of Fishbane's insights into Judaism to educational purposes and practices. Initial work with Jewish educators on establishing this link encouraged…

  11. Genres and Genre Theory: A Response to Michael Rosen

    ERIC Educational Resources Information Center

    Christie, Frances

    2013-01-01

    This paper responds to Michael Rosen's blog entries, "How Genre Theory Saved the World", arguing that genre theory in the tradition of systemic functional linguistics (SFL) has made an important contribution to language and literacy pedagogy. It emerged in the Australian context in about 1980 and was initially developed in response to…

  12. Interview with Michael S. Dukakis. Interview by Richard Sorian.

    PubMed

    Dukakis, M S

    1992-01-01

    In early 1991, former Massachusetts Gov. Michael Dukakis spent three months at the University of Hawaii School of Public Health studying the state's unique system of health insurance. Recently he talked with JAHP Editor in Chief Richard Sorian about the lessons he learned from looking at Hawaii's "universal health coverage" and why the experience was different in his home state. PMID:10116476

  13. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    ERIC Educational Resources Information Center

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  14. Michael Scott: An Individual and the International System

    ERIC Educational Resources Information Center

    Reardon, Betty

    1971-01-01

    This article describes the efforts of Michael Scott in trying to gain dignity and justice for victims of political violence. It indicates that, though limited, there are still nonviolent recourses open to those who will not use the war system. (Author/JB)

  15. 78 FR 69661 - Michael Canales v. Edison International, EIX, Southern California Edison; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Michael Canales v. Edison International, EIX, Southern California Edison....1, Michael Canales (Complainant) filed a formal complaint against Edison International, EIX...

  16. Dr. Michael DeBakey "is a magician of the heart…"

    MedlinePlus

    ... Home Current Issue Past Issues Then & Now Dr. Michael DeBakey "is a magician of the heart…" Past ... NLM's David Nash and admiring students from the Michael E. DeBakey High School for Health Professionals in ...

  17. Expert system for predicting reaction conditions: the Michael reaction case.

    PubMed

    Marcou, G; Aires de Sousa, J; Latino, D A R S; de Luca, A; Horvath, D; Rietsch, V; Varnek, A

    2015-02-23

    A generic chemical transformation may often be achieved under various synthetic conditions. However, for any specific reagents, only one or a few among the reported synthetic protocols may be successful. For example, Michael β-addition reactions may proceed under different choices of solvent (e.g., hydrophobic, aprotic polar, protic) and catalyst (e.g., Brønsted acid, Lewis acid, Lewis base, etc.). Chemoinformatics methods could be efficiently used to establish a relationship between the reagent structures and the required reaction conditions, which would allow synthetic chemists to waste less time and resources in trying out various protocols in search for the appropriate one. In order to address this problem, a number of 2-classes classification models have been built on a set of 198 Michael reactions retrieved from literature. Trained models discriminate between processes that are compatible and respectively processes not feasible under a specific reaction condition option (feasible or not with a Lewis acid catalyst, feasible or not in hydrophobic solvent, etc.). Eight distinct models were built to decide the compatibility of a Michael addition process with each considered reaction condition option, while a ninth model was aimed to predict whether the assumed Michael addition is feasible at all. Different machine-learning methods (Support Vector Machine, Naive Bayes, and Random Forest) in combination with different types of descriptors (ISIDA fragments issued from Condensed Graphs of Reactions, MOLMAP, Electronic Effect Descriptors, and Chemistry Development Kit computed descriptors) have been used. Models have good predictive performance in 3-fold cross-validation done three times: balanced accuracy varies from 0.7 to 1. Developed models are available for the users at http://infochim.u-strasbg.fr/webserv/VSEngine.html . Eventually, these were challenged to predict feasibility conditions for ∼50 novel Michael reactions from the eNovalys database (originally

  18. Expert system for predicting reaction conditions: the Michael reaction case.

    PubMed

    Marcou, G; Aires de Sousa, J; Latino, D A R S; de Luca, A; Horvath, D; Rietsch, V; Varnek, A

    2015-02-23

    A generic chemical transformation may often be achieved under various synthetic conditions. However, for any specific reagents, only one or a few among the reported synthetic protocols may be successful. For example, Michael β-addition reactions may proceed under different choices of solvent (e.g., hydrophobic, aprotic polar, protic) and catalyst (e.g., Brønsted acid, Lewis acid, Lewis base, etc.). Chemoinformatics methods could be efficiently used to establish a relationship between the reagent structures and the required reaction conditions, which would allow synthetic chemists to waste less time and resources in trying out various protocols in search for the appropriate one. In order to address this problem, a number of 2-classes classification models have been built on a set of 198 Michael reactions retrieved from literature. Trained models discriminate between processes that are compatible and respectively processes not feasible under a specific reaction condition option (feasible or not with a Lewis acid catalyst, feasible or not in hydrophobic solvent, etc.). Eight distinct models were built to decide the compatibility of a Michael addition process with each considered reaction condition option, while a ninth model was aimed to predict whether the assumed Michael addition is feasible at all. Different machine-learning methods (Support Vector Machine, Naive Bayes, and Random Forest) in combination with different types of descriptors (ISIDA fragments issued from Condensed Graphs of Reactions, MOLMAP, Electronic Effect Descriptors, and Chemistry Development Kit computed descriptors) have been used. Models have good predictive performance in 3-fold cross-validation done three times: balanced accuracy varies from 0.7 to 1. Developed models are available for the users at http://infochim.u-strasbg.fr/webserv/VSEngine.html . Eventually, these were challenged to predict feasibility conditions for ∼50 novel Michael reactions from the eNovalys database (originally

  19. Domino Michael-Michael and Aldol-Aldol Reactions: Diastereoselective Synthesis of Functionalized Cyclohexanone Derivatives Containing Quaternary Carbon Center.

    PubMed

    Ghorai, Manas K; Halder, Sandipan; Das, Subhomoy

    2015-10-01

    A simple strategy for the synthesis of highly functionalized cyclohexanone derivatives containing an all-carbon quaternary center from α-(aryl/alkyl)methylidene-β-keto esters or β-diketones via a K-enolate mediated domino Michael-Michael reaction sequence with moderate to good yield and excellent diastereoselectivity (de > 99%) is described. Interestingly, Li-base mediated reaction of α-arylmethylidene-β-diketones affords functionalized 3,5-dihydroxy cyclohexane derivatives as the kinetically controlled products via a domino aldol-aldol reaction sequence with excellent diastereoselectivity. Li-enolates of the β-keto esters or β-diketones undergo facile domino Michael-Michael reaction with nitro-olefins to afford the corresponding nitrocyclohexane derivatives in good yields and excellent diastereoselectivity (de > 99%). The formation of the products and the observed stereoselectivity were explained by plausible mechanisms and supported by extensive computational study. An asymmetric version of the protocol was explored with (L)-menthol derived nonracemic substrates, and the corresponding nonracemic cyclohexanone derivatives containing an all-carbon quaternary center were obtained with excellent stereoselectivity (de, ee > 99%).

  20. 76 FR 55904 - Michael J. Donahue; Notice of Termination of Exemption By Implied Surrender and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... Energy Regulatory Commission Michael J. Donahue; Notice of Termination of Exemption By Implied Surrender...: Michael J. Donahue. e. Name and Location of Project: The Fairbanks Mill Project is located on the Sleeper... Information: Mr. Michael J. Donahue, Route 3, Box 269, Lincoln, NH 03251. h. FERC Contact: Tom Papsidero,...

  1. 76 FR 58264 - Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... Energy Regulatory Commission Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender...: Michael J. Donahue. e. Name and Location of Project: The Fairbanks Mill Project is located on the Sleeper... Information: Mr. Michael J. Donahue, Route 3, Box 269, Lincoln, NH 03251. h. FERC Contact: Tom Papsidero,...

  2. Gravitational radiations of generic isolated horizons and nonrotating dynamical horizons from asymptotic expansions

    SciTech Connect

    Wu, Y.-H.; Wang, C.-H.

    2009-09-15

    Instead of using a three-dimensional analysis on quasilocal horizons, we adopt a four-dimensional asymptotic expansion analysis to study the next order contributions from the nonlinearity of general relativity. From the similarity between null infinity and horizons, the proper reference frames are chosen from the compatible constant spinors for an observer to measure the energy-momentum and flux near quasilocal horizons. In particular, we focus on the similarity of Bondi-Sachs gravitational radiation for the quasilocal horizons and compare our results with Ashtekar-Kirshnan flux formula. The quasilocal energy-momentum and flux of generic isolated horizons and nonrotating dynamical horizons are discussed in this paper.

  3. Topological deformation of isolated horizons

    SciTech Connect

    Liko, Tomas

    2008-03-15

    We show that the Gauss-Bonnet term can have physical effects in four dimensions. Specifically, the entropy of a black hole acquires a correction term that is proportional to the Euler characteristic of the cross sections of the horizon. While this term is constant for a single black hole, it will be a nontrivial function for a system with dynamical topologies such as black-hole mergers: it is shown that for certain values of the Gauss-Bonnet parameter, the second law of black-hole mechanics can be violated.

  4. Hall scrambling on black hole horizons

    NASA Astrophysics Data System (ADS)

    Fischler, Willy; Kundu, Sandipan

    2015-08-01

    We explore the effect of the electrodynamics θ angle on the macroscopic properties of black hole horizons. Using only classical Einstein-Maxwell-Chern-Simons theory in (3 +1 ) dimensions, in the form of the membrane paradigm, we show that in the presence of the θ term, a black hole horizon behaves as a Hall conductor, for an observer hovering outside. We study how localized perturbations created on the stretched horizon scramble on the horizon by dropping a charged particle. We show that the θ angle affects the way perturbations scramble on the horizon, in particular, it introduces vortices without changing the scrambling time. This Hall scrambling of information is also expected to occur on cosmological horizons.

  5. Holography beyond the horizon and cosmic censorship

    NASA Astrophysics Data System (ADS)

    Levi, Thomas S.; Ross, Simon F.

    2003-08-01

    We investigate the description of the region behind the event horizon in rotating black holes in the AdS conformal field theory correspondence, using the rotating Bañados-Teitelboim-Zanelli black hole as a concrete example. We extend a technique introduced by Kraus, Ooguri, and Shenker, based on analytically continuing amplitudes defined in a Euclidean space, to include rotation. In the rotating case, boundary amplitudes again have two different bulk descriptions, involving either integration only over the regions outside the black holes’ event horizon, or integration over this region and the region between the event horizon and the Cauchy horizon (inner horizon). We argue that generally, the holographic map will relate the field theory to the region bounded by the Cauchy horizons in spacetime. We also argue that these results suggest that the holographic description of black holes will satisfy strong cosmic censorship.

  6. Variable horizon in a peridynamic medium.

    SciTech Connect

    Silling, Stewart Andrew; Littlewood, David John; Seleson, Pablo

    2014-10-01

    A notion of material homogeneity is proposed for peridynamic bodies with vari- able horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties un- changed. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under homogeneous deformation. These artifacts de- pend on the second derivative of horizon and can be reduced by use of a modified equilibrium equation using a new quantity called the partial stress . Bodies with piece- wise constant horizon can be modeled without ghost forces by using a technique called a splice between the regions. As a limiting case of zero horizon, both partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.

  7. Variable horizon in a peridynamic medium

    DOE PAGES

    Silling, Stewart A.; Littlewood, David J.; Seleson, Pablo

    2015-12-10

    Here, a notion of material homogeneity is proposed for peridynamic bodies with variable horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties unchanged. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under a homogeneous deformation. These artifacts depend on the second derivative of the horizon and can be reduced by employing a modified equilibrium equation using a new quantity called the partial stress. Bodies with piecewise constant horizon can be modeled without ghost forcesmore » by using a simpler technique called a splice. As a limiting case of zero horizon, both the partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.« less

  8. Variable horizon in a peridynamic medium

    SciTech Connect

    Silling, Stewart A.; Littlewood, David J.; Seleson, Pablo

    2015-12-10

    Here, a notion of material homogeneity is proposed for peridynamic bodies with variable horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties unchanged. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under a homogeneous deformation. These artifacts depend on the second derivative of the horizon and can be reduced by employing a modified equilibrium equation using a new quantity called the partial stress. Bodies with piecewise constant horizon can be modeled without ghost forces by using a simpler technique called a splice. As a limiting case of zero horizon, both the partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.

  9. Theory underlying the peripheral vision horizon device

    NASA Technical Reports Server (NTRS)

    Money, K. E.

    1984-01-01

    Peripheral Vision Horizon Device (PVHD) theory states that the likelihood of pilot disorientation in flight is reduced by providing an artificial horizon that provides orientation information to peripheral vision. In considering the validity of the theory, three areas are explored: the use of an artificial horizon device over some other flight instrument; the use of peripheral vision over foveal vision; and the evidence that peripheral vision is well suited to the processing of orientation information.

  10. Smooth horizons and quantum ripples

    NASA Astrophysics Data System (ADS)

    Golovnev, Alexey

    2015-05-01

    Black holes are unique objects which allow for meaningful theoretical studies of strong gravity and even quantum gravity effects. An infalling and a distant observer would have very different views on the structure of the world. However, a careful analysis has shown that it entails no genuine contradictions for physics, and the paradigm of observer complementarity has been coined. Recently this picture was put into doubt. In particular, it was argued that in old black holes a firewall must form in order to protect the basic principles of quantum mechanics. This AMPS paradox has already been discussed in a vast number of papers with different attitudes and conclusions. Here we want to argue that a possible source of confusion is the neglect of quantum gravity effects. Contrary to widespread perception, it does not necessarily mean that effective field theory is inapplicable in rather smooth neighbourhoods of large black hole horizons. The real offender might be an attempt to consistently use it over the huge distances from the near-horizon zone of old black holes to the early radiation. We give simple estimates to support this viewpoint and show how the Page time and (somewhat more speculative) scrambling time do appear.

  11. Horizon entropy with loop quantum gravity methods

    NASA Astrophysics Data System (ADS)

    Pranzetti, Daniele; Sahlmann, Hanno

    2015-06-01

    We show that the spherically symmetric isolated horizon can be described in terms of an SU (2) connection and an su (2)-valued one-form, obeying certain constraints. The horizon symplectic structure is precisely the one of 3d gravity in a first order formulation. We quantize the horizon degrees of freedom in the framework of loop quantum gravity, with methods recently developed for 3d gravity with non-vanishing cosmological constant. Bulk excitations ending on the horizon act very similarly to particles in 3d gravity. The Bekenstein-Hawking law is recovered in the limit of imaginary Barbero-Immirzi parameter. Alternative methods of quantization are also discussed.

  12. Spectroscopy of a weakly isolated horizon

    NASA Astrophysics Data System (ADS)

    Chen, Ge-Rui; Huang, Yong-Chang

    2016-06-01

    The spectroscopy of a weakly isolated horizon has been investigated. We obtain an equally spaced entropy spectrum with its quantum equal to the one given by Bekenstein (Phys Rev D 7:2333, 1973). We demonstrate that the quantization of entropy and area is a generic property of horizons which exists in a wide class of spacetimes admitting weakly isolated horizons. Our method based on the tunneling method also indicates that the entropy quantum of black hole horizons is closely related to Hawking temperature.

  13. Apparent horizon in fluid-gravity duality

    SciTech Connect

    Booth, Ivan; Heller, Michal P.; Plewa, Grzegorz; Spalinski, Michal

    2011-05-15

    This article develops a computational framework for determining the location of boundary-covariant apparent horizons in the geometry of conformal fluid-gravity duality in arbitrary dimensions. In particular, it is shown up to second order and conjectured to hold to all orders in the gradient expansion that there is a unique apparent horizon which is covariantly expressible in terms of fluid velocity, temperature, and boundary metric. This leads to the first explicit example of an entropy current defined by an apparent horizon and opens the possibility that in the near-equilibrium regime there is preferred foliation of apparent horizons for black holes in asymptotically anti-de Sitter spacetimes.

  14. Tribute to Professor Anthony J. McMichael

    PubMed Central

    Swaminathan, Ashwin; Lucas, Robyn M.; Harley, David

    2014-01-01

    Emeritus Professor A. J. “Tony” McMichael (1942–2014) was an internationally renowned and pioneering Australian academic and advocate in epidemiology, who was passionate about understanding the influences of the environment on human health. In an illustrious career spanning more than four decades, he made significant contributions to the scientific community and policy discourse—including ground-breaking research related to the health of children. McMichael was a prolific academic writer with over 300 peer-reviewed papers; 160 book chapters and two sole-authored books. However, his outstanding talent was for integrating complex and seemingly unrelated strands from the environmental and health sciences into a cohesive narrative—and highlighting its relevance to lay persons, scientists and governments alike. He was instrumental in validating this nascent field of research and inspiring many others to follow his lead. PMID:27417490

  15. STS-73 MS Michael E. Lopez-Alegria suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-73 Mission Specialist Michael E. Lopez-Alegria finishes donning his launch/entry suit in the Operations and Checkout Building as a suit technician lends a helping hand. The seven crew members assigned to Mission STS-73 will depart shortly for Launch Pad 39B, where the Space Shuttle Columbia awaits them and a liftoff scheduled to occur no earlier than 10:46 a.m. EDT.

  16. STS-107 Payload Commander Michael Anderson suits up for TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-107 Payload Commander Michael Anderson completes suit check prior to Terminal Countdown Demonstration Test activities, which include a simulated launch countdown at the pad. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia. .

  17. Anti-Selective Organocatalytic Michael Addition between Phenylacetaldehyde and Nitrostyrene.

    PubMed

    Donadío, Lucía Gandolfi; Galetti, Mariana A; Giorgi, Gianluca; Rasparini, Marcello; Comin, Maria J

    2016-09-01

    Using the reaction between phenylacetaldehyde and nitrostyrene catalyzed by pyrrolidine as a simple model, we have studied the diastereochemical outcome of the organocatalytic Michael reactions between benzylic aldehydes and nitrostyrenes. We found that the anti adduct was obtained in high yield and diastereoselection as was demonstrated by the X-ray structure of the product. In situ NMR studies showed a different reaction pathway when compared to aliphatic aldehydes that yield the syn adduct as major isomer. PMID:27442526

  18. Reconceptualizing Knowledge at the Mathematical Horizon

    ERIC Educational Resources Information Center

    Zazkis, Rina; Mamolo, Ami

    2011-01-01

    This article extends the notion of "knowledge at the mathematical horizon" or "horizon knowledge" introduced by Ball and colleagues as a part of teachers' subject matter knowledge. Our focus is on teachers' mathematical knowledge beyond the school curriculum, that is, on mathematics learnt during undergraduate college or university studies. We…

  19. Horizon Report: 2009 Economic Development Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Scott, C.; Smith, R.; Stone, S.

    2009-01-01

    The New Media Consortium's Horizon Project is an ongoing research project that seeks to identify and describe emerging technologies likely to have a large impact in education and other industries around the world over a five-year time period. The chief products of the project are the "Horizon Reports", an annual series of publications that…

  20. The NMC Horizon Report: 2015 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming years on a variety of sectors around the globe. This "2015 Horizon…

  1. Expanding your horizons in science and mathematics

    NASA Technical Reports Server (NTRS)

    Palmer, Cynthia E. A.

    1995-01-01

    The purpose of the 'Expanding Your Horizons in Science and Mathematics' program is to interest young women in grades six through twelve in a variety of careers where mathematics and science are important. Progress in encouraging young women to take courses in mathematics, science, and technological subjects is discussed. Also included are adult, student, and organizational information packets used for 'Expanding Your Horizons' conferences.

  2. Project Horizon: How Utah Is Reducing Recidivism.

    ERIC Educational Resources Information Center

    Robinson, Daimar

    2000-01-01

    Project Horizon, Utah's statute to reduce the economic and social cost of recidivism, shifted funding for correctional education to the state education agency. Parolees who participated in Project Horizon had an 18-20 percent lower recidivism rate than nonparticipants and found post-release jobs 89 percent of the time. (JOW)

  3. The NMC Horizon Report: 2014 Library Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2014-01-01

    The internationally recognized "NMC Horizon Report" series and regional "NMC Technology Outlooks" are part of the NMC Horizon Project, a 12-year effort established in 2002 that annually identifies and describes emerging technologies likely to have a large impact over the coming five years in every sector of education around the…

  4. The Horizon Report: 2010 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Witchey, H.; Smith, R.; Levine, A.; Haywood, K.

    2010-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years on a variety of sectors around the globe. This volume, the "2010 Horizon…

  5. Something special at the event horizon

    NASA Astrophysics Data System (ADS)

    Eune, Myungseok; Gim, Yongwan; Kim, Wontae

    2014-12-01

    We revisit the free-fall energy density of scalar fields semiclassically by employing the trace anomaly on a two-dimensional Schwarzschild black hole with respect to various black hole states in order to clarify whether something special at the horizon happens or not. For the Boulware state, the energy density at the horizon is always negative divergent, which is independent of initial free-fall positions. However, in the Unruh state the initial free-fall position is responsible for the energy density at the horizon and there is a critical point to determine the sign of the energy density at the horizon. In particular, a huge negative energy density appears when the freely falling observer is dropped just near the horizon. For the Hartle-Hawking state, it may also be positive or negative depending on the initial free-fall position, but it is always finite. Finally, we discuss physical consequences of these calculations.

  6. Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors

    PubMed Central

    Men, Ruizhi; Li, Ning; Ding, Chihong; Tang, Yingzhan; Xing, Yachao; Ding, Wanjing; Ma, Zhongjun

    2016-01-01

    Background: The fruits of some varieties of genus Physalis have been used as delicious fruits and functional food in the Northeast of China. Materials and Methods: To reveal the functional material basis, we performed bioactivity-guided phytochemical research and chemopreventive effect assay of the constituents from Physalis minima. Results: It was demonstrated that the ethyl acetate extract of P. minima L. (EEPM) had potential quinone reductase (QR) inducing activity with induction ratio (IR, QR induction activity) value of 1.47 ± 0.24, and glutathione binding property as potential Michael reaction acceptors (with an α, β-unsaturated ketone moiety). Furthermore, bioactivity-guided phytochemical research led eight compounds (1–8), which were elucidated as 3-isopropyl-5-acetoxycyclohexene-2-one-1 (1), isophysalin B (2), physalin G (3), physalin D (4), physalin I (5), physordinose B (6), stigmasterol-3-O-β-D-glucopyranoside (7) and 5α-6β-dihydroxyphysalin R (8) on the basis of nuclear magnetic resonance spectroscopy analyses and HRESIMS. Then, isophysalin B (2) and physordinose B (6) showed significant QR inducing activity with IR value of 2.80 ± 0.19 and 2.38 ± 0.46, respectively. SUMMARY An ultra-performance liquid chromatographic method with glutathione as the substrate was used to detect the Michael reaction acceptors in extracts of Physalis minima (EPM)We investigated the chemical constituents of EPM guided by biological activity methodIsophysalin B (1) and physordinose B (6) showed strong quinone reductase inducing activity with induction ratio values of 2.80 ± 0.19 and 2.38 ± 0.46This study generated useful information for consumers and many encourage researchers to utilize edible fruits from Physalis as a source of phytochemicals Abbreviations used: EPM: Extracts of Physalis minima, EEPM: Ethyl acetate extract of Physalis minima L., GSH: Glutathione, MRAs: Michael reaction acceptors, QR: Quinone reductase. PMID:27279713

  7. Quasilocal approach to general universal horizons

    NASA Astrophysics Data System (ADS)

    Maciel, Alan

    2016-05-01

    Theories of gravity with a preferred foliation usually display arbitrarily fast signal propagation, changing the black hole definition. A new inescapable barrier, the universal horizon, has been defined and many static and spherically symmetric examples have been studied in the literature. Here, we translate the usual definition of the universal horizon in terms of an optical scalar built with the preferred flow defined by the preferred spacetime foliation. The new expression has the advantages of being of quasilocal nature and independent of specific spacetime symmetries in order to be well defined. Therefore, we propose it as a definition for general quasilocal universal horizons. Using the new formalism, we show that there is no universal analog of cosmological horizons for Friedmann-Lemaître-Robertson-Walker models for any scale factor function, and we also state that quasilocal universal horizons are restricted to trapped regions of the spacetime. Using the evolution equation, we analyze the formation of universal horizons under a truncated Hořava-Lifshitz theory, in spherical symmetry, showing the existence of regions in parameter space where the universal horizon formation cannot be smooth from the center, under some physically reasonable assumptions. We conclude with our view on the next steps for the understanding of black holes in nonrelativistic gravity theories.

  8. STS-107 Payload Commander Michael Anderson suits up for TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. - STS-107 Payload Commander Michael Anderson smiles as he undergoes suit check prior to Terminal Countdown Demonstration Test activities, which include a simulated launch countdown at the pad. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia. .

  9. STS-84 M.S. Michael Foale arriving for TCDT

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-84 Mission Specialist C. Michael Foale, who will become the fifth U.S. astronaut to live and work on the Russian Space Station Mir, arrives at KSCs Shuttle Landing Facility for the STS-84 Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. Foale will be dropped off on Mir when the Space Shuttle Atlantis docks with Mir next month. He will become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth on Atlantis after about four months on the orbiting station. STS-84 will be the sixth Shuttle- Mir docking. Liftoff is targeted for May 15.

  10. STS-89 M.S. Michael Anderson suits up

    NASA Technical Reports Server (NTRS)

    1998-01-01

    STS-89 Mission Specialist Michael Anderson smiles as he completes the donning of his launch/entry suit in the Operations and Checkout (O&C) Building. A major in the U.S. Air Force, Anderson has a master of science degree in physics from Creighton University. He and six fellow crew members will soon depart the O&C and head for Launch Pad 39A, where the Space Shuttle Endeavour will lift off during a launch window that opens at 9:43 p.m. EST, Jan. 22. STS-89 is the eighth of nine planned missions to dock the Space Shuttle with Russia's Mir space station.

  11. STS-73 MS Michael E. Lopez-Alegria suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-73 Mission Specialist Michael E. Lopez-Alegria dons his launch/entry suit in the Operations and Checkout Building with assistance from a suit technician. STS-73 will be the first trip into space for Lopez-Alegria, who considers both Madrid, Spain, and Mission Viejo, California, to be his hometowns. Lopez-Alegria and six fellow crew members will departly shortly for Launch Pad 39B, where the Space Shuttle Columbia is undergoing final preparations for liftoff during a two and a half launch window opening at 9:41 a.m. EDT, Oct. 7.

  12. STS-107 Payload Commander Michael Anderson checks equipment at SPACEHAB

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-107 Payload Commander Michael Anderson checks equipment during training at SPACEHAB. STS-107 is a research mission. The primary payload is the first flight of the SHI Research Double Module (SHI/RDM). The experiments range from material sciences to life sciences (many rats). Also part of the payload is the Fast Reaction Experiments Enabling Science, Technology, Applications and Research (FREESTAR) that incorporates eight high priority secondary attached shuttle experiments. STS-107 is scheduled to launch July 11, 2002

  13. STS-69 Mission Specialist Michael L. Gernhardt suits up

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-69 Mission Specialist Michael L. Gernhardt dons his launch/entry suit in the Operations and Checkout Building with assistance from a suit technician. STS-69 will be the first spaceflight for Gernhardt, who is scheduled to perform an extravehicular activity, or spacewalk, during the course of the mission. He and four fellow crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Endeavour awaits liftoff during a two and a half hour window opening at 11:09 a.m. EDT.

  14. STS-81 Commander Michael Baker at SLF for TCDT

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-81 Mission Commander Michael A. Baker arrives at KSC's Shuttle Landing Facility in his NASA T-38 jet. He and five other crew members will participate in the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for the planned Jan. 12 launch. STS-81 will be the fifth Shuttle-Mir docking. During the flight, Mission Specialist J.M. 'Jerry' Linenger will transfer to the Russian Mir Space Station for an extended stay, replacing astronaut John E. Blaha, who will return to Earth on the Space Shuttle orbiter Atlantis at the conclusion of the scheduled nine-day STS-81 mission.

  15. Unruh effect without Rindler horizon

    NASA Astrophysics Data System (ADS)

    Nicolaevici, Nistor

    2015-02-01

    We investigate the Unruh effect for a massless scalar field in the two-dimensional Minkowski space in the presence of a uniformly accelerated perfect mirror, with the trajectory of the mirror chosen in such a way that the mirror completely masks the Rindler horizon from the space-time region of interest. We find that the characteristic thermodynamical properties of the effect remain unchanged, i.e. the response of a uniformly co-accelerated Unruh detector and the distribution of the Rindler particles retain their thermal form. However, since in this setup there are no unobserved degrees of freedom of the field, the thermal statistics of the Rindler particles are inconsistent with an initial pure vacuum, which leads us to reconsider the problem for the more physical case when the mirror is inertial in the past. In these conditions we find that the distribution of the Rindler particles is non-thermal even in the limit of infinite acceleration times, but effective thermal statistics can be recovered provided that one is restricted to the expectation values of smeared operators associated with finite norm Rindler states. We explain how the thermal statistics in our problem can be understood in analogy with those in the conventional version of the effect.

  16. Nearly Finished Genomes Produced Using Gel Microdroplet Culturing (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema

    Fitzsimmons, Michael [LANL

    2016-07-12

    Michael Fitzsimmons from Los Alamos National Laboratory gives a talk titled "Nearly Finished Genomes Produced Using Gel Microdroplet Culturing" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  17. Nearly Finished Genomes Produced Using Gel Microdroplet Culturing (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    SciTech Connect

    Fitzsimmons, Michael

    2012-06-01

    Michael Fitzsimmons from Los Alamos National Laboratory gives a talk titled "Nearly Finished Genomes Produced Using Gel Microdroplet Culturing" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  18. Horizon supertranslation and degenerate black hole solutions

    NASA Astrophysics Data System (ADS)

    Cai, Rong-Gen; Ruan, Shan-Ming; Zhang, Yun-Long

    2016-09-01

    In this note we first review the degenerate vacua arising from the BMS symmetries. According to the discussion in [1] one can define BMS-analogous supertranslation and superrotation for spacetime with black hole in Gaussian null coordinates. In the leading and subleading orders of near horizon approximation, the infinitely degenerate black hole solutions are derived by considering Einstein equations with or without cosmological constant, and they are related to each other by the diffeomorphism generated by horizon supertranslation. Higher order results and degenerate Rindler horizon solutions also are given in appendices.

  19. Black hole entropy and isolated horizons thermodynamics.

    PubMed

    Ghosh, Amit; Perez, Alejandro

    2011-12-01

    We present a statistical mechanical calculation of the thermodynamical properties of (nonrotating) isolated horizons. The introduction of the Planck scale allows for the definition of a universal horizon temperature (independent of the mass of the black hole) and a well-defined notion of energy (as measured by suitable local observers) proportional to the horizon area in Planck units. The microcanonical and canonical ensembles associated with the system are introduced. Black hole entropy and other thermodynamical quantities can be consistently computed in both ensembles and results are in agreement with Hawking's semiclassical analysis for all values of the Immirzi parameter.

  20. Primary-tertiary diamine-catalyzed Michael addition of ketones to isatylidenemalononitrile derivatives.

    PubMed

    Kumar, Akshay; Chimni, Swapandeep Singh

    2014-01-01

    Simple primary-tertiary diamines easily derived from natural primary amino acids were used to catalyze the Michael addition of ketones with isatylidenemalononitrile derivatives. Diamine 1a in combination with D-CSA as an additive provided Michael adducts in high yield (up to 94%) and excellent enantioselectivity (up to 99%). The catalyst 1a was successfully used to catalyze the three-component version of the reaction by a domino Knoevenagel-Michael sequence. The Michael adduct 4a was transformed into spirooxindole 6 by a reduction with sodium borohydride in a highly enantioselective manner.

  1. Horizon Entropy from Quantum Gravity Condensates.

    PubMed

    Oriti, Daniele; Pranzetti, Daniele; Sindoni, Lorenzo

    2016-05-27

    We construct condensate states encoding the continuum spherically symmetric quantum geometry of a horizon in full quantum gravity, i.e., without any classical symmetry reduction, in the group field theory formalism. Tracing over the bulk degrees of freedom, we show how the resulting reduced density matrix manifestly exhibits a holographic behavior. We derive a complete orthonormal basis of eigenstates for the reduced density matrix of the horizon and use it to compute the horizon entanglement entropy. By imposing consistency with the horizon boundary conditions and semiclassical thermodynamical properties, we recover the Bekenstein-Hawking entropy formula for any value of the Immirzi parameter. Our analysis supports the equivalence between the von Neumann (entanglement) entropy interpretation and the Boltzmann (statistical) one. PMID:27284642

  2. Horizon Entropy from Quantum Gravity Condensates.

    PubMed

    Oriti, Daniele; Pranzetti, Daniele; Sindoni, Lorenzo

    2016-05-27

    We construct condensate states encoding the continuum spherically symmetric quantum geometry of a horizon in full quantum gravity, i.e., without any classical symmetry reduction, in the group field theory formalism. Tracing over the bulk degrees of freedom, we show how the resulting reduced density matrix manifestly exhibits a holographic behavior. We derive a complete orthonormal basis of eigenstates for the reduced density matrix of the horizon and use it to compute the horizon entanglement entropy. By imposing consistency with the horizon boundary conditions and semiclassical thermodynamical properties, we recover the Bekenstein-Hawking entropy formula for any value of the Immirzi parameter. Our analysis supports the equivalence between the von Neumann (entanglement) entropy interpretation and the Boltzmann (statistical) one.

  3. Schizophrenia: Hope on the Horizon.

    PubMed

    Sullivan, Patrick F

    2015-01-01

    In July 2014, an international consortium of schizophrenia researchers co-founded by the author mounted the largest biological experiment in the history of psychiatry and found eighty new regions in the genome associated with the illness. With many more avenues for exploring the biological underpinnings of schizophrenia now available to neuroscientists, hope may be on the way for the estimated 2.4 million Americans and 1 in 100 people worldwide affected by the illness, one in which drugs have limited impact and there is no known cure. PMID:27358664

  4. Dr. Marco Marra: Pioneer and Visionary in Cancer Genomics Research | Office of Cancer Genomics

    Cancer.gov

    Dr. Marco Marra is a highly distinguished genomics and bioinformatics researcher. He is the Director of Canada’s Michael Smith Genome Sciences Centre at the BC Cancer Agency and holds a faculty position at the University of British Columbia. The Centre is a state-of-the-art sequencing facility in Vancouver, Canada, with a major focus on the study of cancers.  Many of their research projects are undertaken in collaborations with other Canadian and international institutions.

  5. 75 FR 22436 - Michael Williams-Control Exemption-St. Maries River Railroad, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Surface Transportation Board Michael Williams-Control Exemption-St. Maries River Railroad, Inc. Michael Williams (applicant),\\1\\ a noncarrier, has filed a verified notice of exemption to acquire control of St... from STMA's parent, Potlatch Land & Lumber, LLC, by Williams Group, Inc. (WG).\\2\\ Applicant...

  6. 77 FR 61596 - Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing Take notice that on September 28, 2012, Michael I. Wheatley and Drummond E. Garrison submitted for filing,...

  7. A Response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts"

    ERIC Educational Resources Information Center

    Cranton, Patricia; Kasl, Elizabeth

    2012-01-01

    This article presents the authors' response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts". The authors begin by noting their appreciation of Michael Newman's challenge to transformative learning theory. In their response, the authors review and comment on the fatal flaws presented by Newman and then…

  8. 77 FR 41181 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. Massachusetts...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey... (PURPA), CAlifornians for Renewable Energy, Inc., Michael E. Boyd, and Robert M. Sarvey...

  9. Markets, Marx, Modernity and Mathematics Education: A Response to Michael Apple.

    ERIC Educational Resources Information Center

    Gates, Peter

    This paper is a response to Michael Apple's paper, "What Postmodernists Forget: Cultural Capital and Official Knowledge." The paper advocates Michael's identification of the current dangers and processes of the growth of new right ideologies in the development of subjectivity, society, and education. The differences in success in the education…

  10. STS-107 Crew Interviews: Michael Anderson, Mission Specialist

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-107 Mission Specialist 3 and Payload Commander Michael Anderson is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. He outlines his role in the mission in general, and specifically in conducting onboard science experiments. He discusses the following instruments and sets of experiments in detail: CM2 (Combustion Module 2), FREESTAR (Fast Reaction Enabling Science Technology and Research, MEIDEX (Mediterranean Israeli Dust Experiment) and MGM (Mechanics of Granular Materials). Anderson also mentions on-board activities and responsibilities during launch and reentry, mission training, and microgravity research. In addition, he touches on the dual work-shift nature of the mission, the use of crew members as research subjects including pre and postflight monitoring activities, the emphasis on crew safety during training and the value of international cooperation.

  11. Expedition 8 Crew Interviews: C. Michael Foale - CDR

    NASA Technical Reports Server (NTRS)

    2003-01-01

    C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

  12. STS-83 Mission Specialist Michael L. Gernhardt suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-83 Mission Specialist Michael L. Gernhardt is assisted into his launch/entry suit in the Operations and Checkout (O&C) Building. He first flew in this capacity on STS-69. He has been a professional deep sea diver and engineer and holds a doctorate in bioengineering. Gernhardt will be in charge of the Blue shift and as flight engineer will operate and maintain the orbiter while Halsell and Still are asleep as members of the Red shift. He will also back them up on the flight deck during the ascent and re- entry phases of the mission. Gernhardt and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Columbia will lift off during a launch window that opens at 2:00 p.m. EST, April 4.

  13. STS-94 Mission Specialist Michael Gernhardt suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-94 Mission Specialist Michael L. Gernhardt is assisted into his launch/entry suit by a suit technician in the Operations and Checkout (O&C) Building. He first flew in this capacity on STS- 69. He has been a professional deep sea diver and engineer and holds a doctorate in bioengineering. Gernhardt will be in charge of the Blue shift and as flight engineer will operate and maintain the orbiter while Halsell and Still are asleep as members of the Red shift. He will also back them up on the flight deck during the ascent and re-entry phases of the mission. Gernhardt and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Columbia will lift off during a launch window that opens at 1:50 a.m. EDT, July opportunity to lift off before Florida summer rain showers reached the space center.

  14. Astronaut C. Michael Foale prepares to return to JSC

    NASA Technical Reports Server (NTRS)

    1997-01-01

    At the Skid Strip on Cape Canaveral Air Station, astronaut C. Michael Foale prepares to return to the Johnson Space Center in Houston, TX. The Oct. 6 landing of the Space Shuttle orbiter Atlantis following the successful STS-86 mission returned Foale to Earth after an approximate four-and-a-half-month stay aboard the Russian Space Station Mir. Foale, a member of the Mir 24 crew, was dropped off on the Russian space station during the STS-84 mission in mid-May. He joined the STS-86 crew aboard Atlantis for the return trip to Earth. STS-86 was the seventh docking of the Space Shuttle with the Mir. STS-86 Mission Specialist David A. Wolf replaced Foale on the Russian station.

  15. STS-84 M.S. Michael Foale suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-84 Mission Specialist C. Michael Foale laughs during a rare moment of relaxation just a few hours before the scheduled launch. Foale is donning his launch and entry suit in the Operations and Checkout Building. This will be Foales fourth space flight. Foale and six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Atlantis awaits liftoff on a mission to dock with the Russian Space Station Mir. Foale will transfer to Mir for an approximate four- month stay, replacing U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on the Russian space station since Jan. 15. Linenger will return to Earth on Atlantis.

  16. Astronaut C. Michael Foale prepares to return to JSC

    NASA Technical Reports Server (NTRS)

    1997-01-01

    At the Skid Strip on Cape Canaveral Air Station, astronaut C. Michael Foale and his children (5-year-old Jenna, left, and 3- year-old Ian, in Foale's arms) prepare to return to the Johnson Space Center in Houston, TX. The Oct. 6 landing of the Space Shuttle orbiter Atlantis following the successful STS-86 mission returned Foale to Earth after an approximate four-and-a-half- month stay aboard the Russian Space Station Mir. Foale, a member of the Mir 24 crew, was dropped off on the Russian space station during the STS-84 mission in mid-May. He joined the STS-86 crew aboard Atlantis for the return trip to Earth. STS-86 was the seventh docking of the Space Shuttle with the Mir. STS-86 Mission Specialist David A. Wolf replaced Foale on the Russian station.

  17. Unprecedented Double aza-Michael Addition within a Sapphyrin Core.

    PubMed

    Figueira, Flávio; Marques, Igor; Farinha, Andreia S F; Tomé, Augusto C; Cavaleiro, José A S; Silva, Artur M S; Sessler, Jonathan; Félix, Vítor; Tomé, João P C

    2016-09-26

    A novel sapphyrin derivative was obtained from the reaction between a free-base sapphyrin and dimethyl acetylenedicarboxylate (DMAD). The formation of the new compound involved a double aza-Michael addition of two pyrrolic NH groups to a DMAD molecule, with the formation of a disubstituted ethano bridge. The NMR spectral data reveal a product with an unsymmetrical structure; DFT calculations provided support for a structure in which the ethano bridge links two adjacent pyrrole units. The present study provides a seemingly unprecedented example of an N,N'-dinucleophile reacting with DMAD to form a heterocyclic compound in which the two N-atoms are linked to the two sp(3) carbon atoms derived from a substituted acetylene. PMID:27533480

  18. Michael Crotty and nursing phenomenology: criticism or critique?

    PubMed

    Barkway, P

    2001-09-01

    In 1996 Michael Crotty published the text Phenomenology and nursing research in which he criticised many nurse researchers' interpretation of the methodology of phenomenology and their utilisation of phenomenology as a method for undertaking qualitative nursing research. Crotty's thesis proposes that the research conducted by nurses is not phenomenology according to the European tradition, but a North American hybrid. Subsequently, debate has occurred amongst nurses as to whether Crotty's work is a scholarly, reasoned critique or a severe, judgmental, fault-finding criticism of nursing research. Considering the increasing utilisation of phenomenology as a methodology that informs nursing research, this debate is an important one and has implications for the conduct of research. This article examines this debate and the implications of Crotty's work for phenomenological research in nursing.

  19. STS-84 Mission Specialist C. Michael Foale in white room

    NASA Technical Reports Server (NTRS)

    1997-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist C. Michael Foale prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

  20. 78 FR 70976 - Horizons ETFs Management (USA) LLC and Horizons ETF Trust; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... will include both institutional and retail investors.\\21\\ The price at which Shares trade will be... COMMISSION Horizons ETFs Management (USA) LLC and Horizons ETF Trust; Notice of Application November 21, 2013... management investment companies to issue shares (``Shares'') redeemable in large aggregations...

  1. On the Bartnik mass of apparent horizons

    NASA Astrophysics Data System (ADS)

    Mantoulidis, Christos; Schoen, Richard

    2015-10-01

    In this paper we characterize the intrinsic geometry of apparent horizons (outermost marginally outer trapped surfaces) in asymptotically flat spacetimes; that is, the Riemannian metrics on the two sphere which can arise. Furthermore we determine the minimal ADM mass of a spacetime containing such an apparent horizon. The results are conveniently formulated in terms of the quasi-local mass introduced by Bartnik (1989 Phys. Rev. Lett. 62 2346-8). The Hawking mass provides a lower bound for Bartnik’s quasilocal mass on apparent horizons by way of Penrose’s conjecture on time symmetric slices, proven in 1997 by Huisken and Ilmanen (2001 J. Differ. Geom. 59 353-437) and in full generality in 1999 by Bray (2001 J. Differ. Geom. 59 177-267). We compute Bartnik’s mass for all non-degenerate apparent horizons and show that it coincides with the Hawking mass. As a corollary we disprove a conjecture due to Gibbons in the spirit of Thorne’s hoop conjecture (Gibbons 2009 arXiv:0903.1580), and construct a new large class of examples of apparent horizons with the integral of the negative part of the Gauss curvature arbitrarily large.

  2. Star-Paths, Stones and Horizon Astronomy

    NASA Astrophysics Data System (ADS)

    Brady, Bernadette

    2015-05-01

    Archaeoastronomers tend to approach ancient monuments focusing on the landscape and the horizon calendar events of sun and moon and, due to problems with precession, generally ignore the movement of the stars. However, locating the position of solar calendar points on the horizon can have other uses apart from calendar and/or cosmological purposes. This paper firstly suggests that the stars do not need to be ignored. By considering the evidence of the Phaenomena, a sky poem by Aratus of Soli, a third century BC Greek poet, and his use of second millennium BC star lore fragments, this paper argues that the stars were a part of the knowledge of horizon astronomy. Aratus' poem implied that the horizon astronomy of the late Neolithic and Bronze Age periods included knowledge of star-paths or 'linear constellations' that were defined by particular horizon calendar events and other azimuths. Knowledge of such star-paths would have enabled navigation and orientation, and by using permanent markers, constructed or natural, to define these paths, they were immune to precession as the stones could redefine a star-path for a future generation. Finally the paper presents other possible intentions behind the diverse orientation of passage tombs and some megalithic sites.

  3. New horizons in lipoprotein research.

    PubMed

    Scott, J

    1987-08-01

    The present decade was heralded by the identification of cDNA clones for apo-AI, HMG CoA reductase and the LDL receptor. Today we have descriptions of many other proteins involved in lipid metabolism and of the genes that code for them. Structure and function have been probed by techniques for protein blotting and by in vitro mutagenesis of proteins. The details of gene regulation are now beginning to be unravelled and we can expect exciting new developments in the understanding of how gene expression affects plasma lipoprotein levels. New and powerful techniques have been established for identifying known mutations and for detecting new mutations. Discovery of restriction fragment length polymorphisms have allowed the association between these DNA markers and particular genes involved in lipoprotein metabolism to be probed. The extent to which particular gene loci contribute to the variation in plasma cholesterol levels is being analysed using the methods of genetic epidemiology. With the advent of methods for establishing linkage and physical maps of the human genome, it is now possible to identify the genes responsible for any disorder in which clinical material can be assembled. From this rapidly advancing knowledge it must be anticipated that many new exciting diagnostic and therapeutic possibilities will emerge.

  4. Evolving Hořava cosmological horizons

    NASA Astrophysics Data System (ADS)

    Fathi, Mohsen; Mohseni, Morteza

    2016-09-01

    Several sets of radially propagating null congruence generators are exploited in order to form 3-dimensional marginally trapped surfaces, referred to as black hole and cosmological apparent horizons in a Hořava universe. Based on this method, we deal with the characteristics of the 2-dimensional space-like spheres of symmetry and the peculiarities of having trapping horizons. Moreover, we apply this method in standard expanding and contracting FLRW cosmological models of a Hořava universe to investigate the conditions under which the extra parameters of the theory may lead to trapped/anti-trapped surfaces both in the future and in the past. We also include the cases of negative time, referred to as the finite past, and discuss the formation of anti-trapped surfaces inside the cosmological apparent horizons.

  5. Hair-brane ideas on the horizon

    NASA Astrophysics Data System (ADS)

    Martinec, Emil J.; Niehoff, Ben E.

    2015-11-01

    We continue an examination of the microstate geometries program begun in arXiv:1409.6017, focussing on the role of branes that wrap the cycles which degenerate when a throat in the geometry deepens and a horizon forms. An associated quiver quantum mechanical model of minimally wrapped branes exhibits a non-negligible fraction of the gravitational entropy, which scales correctly as a function of the charges. The results suggest a picture of AdS3/CFT2 duality wherein the long string that accounts for BTZ black hole entropy in the CFT description, can also be seen to inhabit the horizon of BPS black holes on the gravity side.

  6. Aerosol physical properties from satellite horizon inversion

    NASA Technical Reports Server (NTRS)

    Gray, C. R.; Malchow, H. L.; Merritt, D. C.; Var, R. E.; Whitney, C. K.

    1973-01-01

    The feasibility is investigated of determining the physical properties of aerosols globally in the altitude region of 10 to 100 km from a satellite horizon scanning experiment. The investigation utilizes a horizon inversion technique previously developed and extended. Aerosol physical properties such as number density, size distribution, and the real and imaginary components of the index of refraction are demonstrated to be invertible in the aerosol size ranges (0.01-0.1 microns), (0.1-1.0 microns), (1.0-10 microns). Extensions of previously developed radiative transfer models and recursive inversion algorithms are displayed.

  7. East Rim of Endeavour Crater on Horizon

    NASA Technical Reports Server (NTRS)

    2009-01-01

    [figure removed for brevity, see original site]

    A high point on the distant eastern rim of Endeavour Crater is visible on the horizon in this image taken by the panoramic camera (Pancam) on NASA's Mars Exploration Rover Opportunity on March 8, 2009, during the 1,821st Martian day, or sol, of the rover's mission on Mars.

    That portion of Endeavour's rim is about 34 kilometers (21 miles) away from Opportunity's position west of the crater when the image was taken. The width of the image covers approximately one degree of the horizon.

  8. North Rim of Endeavour Crater on Horizon

    NASA Technical Reports Server (NTRS)

    2009-01-01

    [figure removed for brevity, see original site]

    A northern portion of the rim of Endeavour Crater is visible on the horizon of this image taken by the panoramic camera (Pancam) on NASA's Mars Exploration Rover Opportunity on March 7, 2009, during the 1,820st Martian day, or sol, of the rover's mission on Mars.

    That portion of Endeavour's rim is about 20 kilometers (12 miles) away from Opportunity's position west of the crater when the image was taken. The width of the image covers approximately one degree of the horizon.

  9. Expanding your horizons in science and mathematics

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Through the presentation of its Expanding Your Horizons in Science and Mathematics career education conferences for secondary school young women, the Math/Science Network continues its efforts to remove the educational, psychological, and cultural barriers which prevent women from entering math-and science-based careers. The Expanding Your Horizons conferences were presented on 77 college, university and high school campuses across the United States. This year, these unique one day conferences reached 15,500 students, 3,000 parents and educators, and involved 3,000 career women who volunteered their services as conference planners, workshop leaders, speakers, and role models.

  10. Horizons and plane waves: A review

    SciTech Connect

    Hubeny, Veronika E.; Rangamani, Mukund

    2003-11-06

    We review the attempts to construct black hole/string solutions in asymptotically plane wave spacetimes. First, we demonstrate that geometries admitting a covariantly constant null Killing vector cannot admit event horizons, which implies that pp-waves can't describe black holes. However, relaxing the symmetry requirements allows us to generate solutions which do possess regular event horizons while retaining the requisite asymptotic properties. In particular, we present two solution generating techniques and use them to construct asymptotically plane wave black string/brane geometries.

  11. Evidence for a sedimentary siloxane horizon

    SciTech Connect

    Pellenbarg, R.E.; Tevault, D.E.

    1986-07-01

    Selected samples from two Puget Sound sediment cores have been analyzed for poly(organo)siloxanes(silicones). One core was 60 years old at 30-cm depth (ages by lead-210 dating) and showed no evidence for silicones there. The second, 15 years old at depth, exhibited silicones at depth. Clearly shown is evidence for a siloxane horizon in theses two cores, with the presence of the horizon directly related to the fact that silicones have been in widespread use only since World War II. All samples were analyzed by solvent extraction and diffuse reflectance Fourier transform infrared spectrometry. 10 references, 2 figures, 1 table.

  12. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... approximately 7.5 acres of airport property, located at the Michael J Smith Field, be used for aeronautical... Authority to release approximately 7.5 acres of airport property at the Michael J Smith Field. The...

  13. 78 FR 3913 - Public Land Order No. 7807: Withdrawal of Public Lands for the Camp Michael Monsoor Mountain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-17

    ... Bureau of Land Management Public Land Order No. 7807: Withdrawal of Public Lands for the Camp Michael... mining laws, for a period of 20 years for use by the Department of the Navy for the Camp Michael Monsoor... public use for the Department of the Navy. The area, known as Camp Michael Monsoor Mountain...

  14. 75 FR 62635 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program... needed to determine patients' satisfaction with services provided by or through the Michael E. DeBakey.... Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB...

  15. 77 FR 69550 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program... provided by or through the Michael E. DeBakey Home Care Program. DATES: Written comments and... information technology. Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form...

  16. Switchable stereocontrolled divergent synthesis induced by aza-Michael addition of deactivated primary amines under acid catalysis.

    PubMed

    Amara, Z; Drège, E; Troufflard, C; Retailleau, P; Tran Huu-Dau, M-E; Joseph, D

    2014-11-24

    Switchable tandem intramolecular aza-Michael/Michael and double aza-Michael reactions allow the oriented synthesis of highly functionalised cyclic skeletons. Conjugate addition of deactivated anilines triggers chemo- and stereo-divergent ring-closure reaction pathways with a striking selectivity depending on reaction conditions.

  17. Michael Tuomey's 1848 geological survey of South Carolina

    USGS Publications Warehouse

    Nystrom, P.G.

    1999-01-01

    One hundred and fifty years ago, Michael Tuomey completed his 'Report on the Geology of South Carolina,' the result of four years of arduous labor. The report is the first detailed and comprehensive geological description of the entire state, and it includes a geological map that shows the distribution of Coastal Plain and Piedmont-Blue Ridge units. In the sesquicentennial of Tuomey's survey, it is fitting that we recognize his important early contribution to the geology of South Carolina and the southeast. Tuomey's report is a 293-page volume with a 48-page appendix and an index. Although he gave a complete depiction of Coastal Plain geology and delineated Cretaceous, Lower Eocene, Eocene, Miocene, Post-Pliocene, and alluvial units on his map, the emphasis herein is on his mapping of the Piedmont and Blue Ridge. The metamorphic units he delineated are clay slate, mica slate, talcose slate, hornblende slate, gneiss, and lime rock. Gneiss is the most extensive unit on the map. His map shows many elements of the geologic framework we recognize today. The distribution of his clay slate unit corresponds closely with the Carolina slate and Bel Air belts as we know them now. The gneiss between the two clay slate areas matches the Kiokee belt. Areas of mica slate approximate the northern part of the Kings Mountain belt and the Chauga belt. He also recognized that his talcose slate unit was associated with gold deposits. Granitic and basaltic intrusive rocks are also delineated on the map. It shows the Newberry, Columbia, and Liberty Hill granites we recognize today. Basaltic intrusives outlined include the Bush River of western Newberry County, Dutchmans Creek, Big Wateree Creek, and Ogden gabbros. He described the regional extent of diabase dikes as occuring from Virginia to Alabama, noted their preferred direction and diagrammed their near-vertical orientation. He also referred to the distinctive soil and topography that develops on the large gabbros. Michael Tuomey

  18. Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.

    PubMed

    Ciaccio, P J; Jaiswal, A K; Tew, K D

    1994-06-01

    A human oxidoreductase (H-37) that is overexpressed in ethacrynic acid-resistant HT29 colon cells (Ciaccio, P. J., Stuart, J.E., and Tew, K.D. (1993) Mol. Pharmacol. 43, 845-853) has been identified as a dihydrodiol dehydrogenase. Translated protein from a dihydrodiol dehydrogenase cDNA isolated from a library prepared from ethacrynic acid-resistant HT29 cell poly(A+) RNA was recognized by anti-H-37 IgG and was identical in molecular weight with H-37. The isolated cDNA was identical in both nucleotide and amino acid sequences with the recently cloned liver dihydrodiol dehydrogenase (Stolz, A., Hammond, L., Lou, H., Takikawa, H., Ronk, M., and Shively, J.E. (1993) J. Biol. Chem. 268, 10448-10457). Using this cDNA as probe, we have examined its induction by Michael acceptors. The steady state dihydrodiol dehydrogenase mRNA level in the ethacrynic acid-resistant line was increased 30-fold relative to that of wild-type cells. Twenty-four hour treatment of wild-type cells with ethacrynic acid or dimethyl maleate increased mRNA 10-fold and 5-fold, respectively. These changes are accompanied by both increased protein expression and increased NADP-dependent 1-acenaphthenol oxidative activity in cell cytosol. In gel shift assays, compared to wild type controls, increased binding of NAD(P)H quinone oxidoreductase human antioxidant response element (hARE) DNA to redox labile protein complexes present in treated and resistant cell nuclear extract was observed. Ethacrynic acid induced CAT activity 2-fold in Hepa1 cells stably transfected with NAD(P)H quinone oxidoreductase hARE-tk-CAT chimeric gene construct. Thus, dihydrodiol dehydrogenase protein is inducible by de novo synthesis from mRNA by structurally related monofunctional inducer Michael acceptors. Altered in vitro binding of nuclear protein to the hARE is indirect evidence for the involvement of an element similar to hARE in the regulation of dihydrodiol dehydrogenase by these agents. PMID:7515059

  19. Automatic star-horizon angle measurement system

    NASA Technical Reports Server (NTRS)

    Koerber, K.; Koso, D. A.; Nardella, P. C.

    1969-01-01

    Automatic star horizontal angle measuring aid for general navigational use incorporates an Apollo type sextant. The eyepiece of the sextant is replaced with two light detectors and appropriate circuitry. The device automatically determines the angle between a navigational star and a unique point on the earths horizon as seen on a spacecraft.

  20. New Concepts on the Educational Horizon.

    ERIC Educational Resources Information Center

    Gilchrist, Robert S.; Mitchell, Edna

    Four dimensions in education provide a basis for discussing future horizons: (1) curriculum development, (2) teacher education, (3) administration and organization, and (4) research and development. These areas are interdependent, and one cannot be improved or changed without affecting the other areas. Within these areas, some of the broad changes…

  1. Time Horizon in Students' Predictions of Grades.

    ERIC Educational Resources Information Center

    Manger, Terje; Teigen, Karl Halvor

    1988-01-01

    Eight and two months before their final exam, 252 undergraduates in Norway stated their expectations and hopes for examination grades. Correlations between expected and obtained grades were low. A shift from optimism to pessimism occurred. Results confirm the time horizon's crucial role in the prediction of academic achievement. (TJH)

  2. The NMC Horizon Report: 2013 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Freeman, A.

    2013-01-01

    The "NMC Horizon Report: 2013 Museum Edition," is a co-production with the Marcus Institute for Digital Education in the Arts (MIDEA), and examines six emerging technologies for their potential impact on and use in education and interpretation within the museum environment: BYOD (Bring Your Own Device), crowdsourcing, electronic…

  3. Falling through the black hole horizon

    NASA Astrophysics Data System (ADS)

    Brustein, Ram; Medved, A. J. M.

    2015-06-01

    We consider the fate of a small classical object, a "stick", as it falls through the horizon of a large black hole (BH). Classically, the equivalence principle dictates that the stick is affected by small tidal forces, and Hawking's quantum-mechanical model of BH evaporation makes essentially the same prediction. If, on the other hand, the BH horizon is surrounded by a "firewall", the stick will be consumed as it falls through. We have recently extended Hawking's model by taking into account the quantum fluctuations of the geometry and the classical back-reaction of the emitted particles. Here, we calculate the train exerted on the falling stick for our model. The strain depends on the near-horizon state of the Hawking pairs. We find that, after the Page time when the state of the pairs deviates significantly from maximal entanglement (as required by unitarity), the induced strain in our semiclassical model is still parametrically small. This is because the number of the disentangled pairs is parametrically smaller than the BH entropy. A firewall does, however, appear if the number of disentangled pairs near the horizon is of order of the BH entropy, as implicitly assumed in previous discussions in the literature.

  4. Gateway's Horizon: A Center of Excellence

    ERIC Educational Resources Information Center

    Herring, Jayne; Colony, Lee

    2007-01-01

    This article describes Gateway Technical College's Horizon Center for Transportation Technology, located in Kenosha, Wisconsin, which was the product of collaboration with business and industry, community support and a U.S. Department of Labor (DOL) grant. The center, which opened this fall, is a prime example of a sustainable community…

  5. On the differentiability order of horizons

    NASA Astrophysics Data System (ADS)

    Szeghy, D.

    2016-06-01

    Let M be a time oriented Lorentzian manifold and H\\subset M a horizon. We will show that the differentiability order of the horizon can change only once along a generator, i.e. the following holds. If γ :I\\to H is a generator, thus, an inextendable past directed light-like geodesic on the horizon, where I=(α ,β ) or [α ,β ), then there exists a unique parameter {t}0\\in [α ,β ] and a positive integer k≥slant 1 such that the following is true. The horizon H is exactly of class {C}k at γ (t), for every t\\in ({t}0,β ), moreover H is only differentiable, but not of class {C}1 at every point γ (t), for which t\\in (α ,{t}0]. Moreover, if γ (α ) is the endpoint of only one generator then for a suitable space-like submanifold R\\subset H the first cut point of R along γ is γ (α ). Furthermore, all the points γ (t), for which t\\in [α ,{t}0], are non-injectivity points of R along γ . Moreover, if H is smooth at an interior point of γ, then H is smooth at every point of γ. MSC 53C50

  6. Agriculture’s Ethical Horizon, book review

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Roughly 6.5 billion people inhabit the earth, but over 1 billion people regularly go hungry. This food shortfall poses an ethical dilemma for agriculture, and Agriculture's Ethical Horizon grapples with this dilemma. It argues that agricultural productivity has been the quintessential value of agr...

  7. Apparent horizons in binary black hole spacetimes

    NASA Astrophysics Data System (ADS)

    Shoemaker, Deirdre Marie

    Over the last decade, advances in computing technology and numerical techniques have lead to the possible theoretical prediction of astrophysically relevant waveforms in numerical simulations. With the building of gravitational wave detectors such as the Laser Interferometric Gravitational-Wave Observatory, we stand at the epoch that will usher in the first experimental study of strong field general relativity. One candidate source for ground based detection of gravitational waveforms, the orbit and merger of two black holes, is of great interest to the relativity community. The binary black hole problem is the two-body problem in general relativity. It is a stringent dynamical test of the theory. The problem involves the evolution of the Einstein equation, a complex system of non-linear, dynamic, elliptic-hyperbolic equations intractable in closed form. Numerical relativists are now developing the technology to evolve the Einstein equation using numerical simulations. The generation of these numerical I codes is a ``theoretical laboratory'' designed to study strong field phenomena in general relativity. This dissertation reports the successful development and application of the first multiple apparent horizon tracker applied to the generic binary black hole problem. I have developed a method that combines a level set of surfaces with a curvature flow method. This method, which I call the level flow method, locates the surfaces of any apparent horizons in the spacetime. The surface location then is used to remove the singularities from the computational domain in the evolution code. I establish the following set of criteria desired in an apparent horizon tracker: (1)The robustness of the tracker due to its lack of dependence on small changes to the initial guess; (2)The generality of the tracker in its applicability to generic spacetimes including multiple back hole spacetimes; and (3)The efficiency of the tracker algorithm in CPU time. I demonstrate the apparent

  8. Astronaut Michael Collins Undergoes Communications Systems Final Check

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dunned in his space suit, Command Module (CM) pilot Michael Collins does a final check of his communications system before the boarding of the Apollo 11 mission. Launched via a Saturn V launch vehicle, the first manned lunar mission launched from the Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. The 3-man crew aboard the flight consisted of astronauts Collins; Neil A. Armstrong, Mission Commander; and Edwin E. Aldrin, Jr., Lunar Module (LM) Pilot. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. Meanwhile, astronaut Collins piloted the CM in a parking orbit around the Moon. During a 2½ hour surface exploration, the crew collected 47 pounds of lunar surface material which was returned to Earth for analysis. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  9. STS-103 M.S. Michael Foale during TCDT activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    STS-103 Mission Specialist C. Michael Foale (Ph.D.) is ready to take his turn at driving a small armored personnel carrier that is part of emergency egress training during Terminal Countdown Demonstration Test (TCDT) activities. The tracked vehicle could be used by the crew in the event of an emergency at the pad during which the crew must make a quick exit from the area. The TCDT also provides simulated countdown exercises and opportunities to inspect the mission payloads in the orbiter's payload bay. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The other STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith , John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, who are with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

  10. 78 FR 54298 - Horizons ETFs Management (USA) LLC and Horizons ETF Trust; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ..., or treasury bills. 2. Horizons, a Delaware limited liability company registered with the Commission... investment company from suspending the right of redemption or postponing the date of payment of...

  11. The Pluto System As Seen By New Horizons Spacecraft

    NASA Video Gallery

    The Pluto system as NASA’s New Horizons spacecraft saw it in July 2015. This animation, made with real images taken by New Horizons, begins with Pluto flying in for its close-up on July 14; we then...

  12. SETAC launches global horizon scanning/research prioritization project

    EPA Science Inventory

    The SETAC World Council is pleased to announce the initiation of a Global Horizon Scanning and Prioritization Project aimed at identifying geographically specific research needs to address stressor impacts on environmental quality. In recent years, horizon scanning and research ...

  13. Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.

    PubMed

    Anand, Preetha; Sung, Bokyung; Kunnumakkara, Ajaikumar B; Rajasekharan, Kallikat N; Aggarwal, Bharat B

    2011-12-15

    Curcumin, a diferuloylmethane, has been shown to exhibit anti-inflammatory and anti-proliferative activities. Whereas curcumin has both a Michael acceptor and a Michael donor units, its analogues dibenzoylmethane (DBM, a component of licorice) and dibenzoylpropane (DBP) have a Michael donor but not a Michael acceptor unit, and the analogue dibenzylideneacetone (DBA) has a Michael acceptor unit. In the current report, we investigated the potency of DBM, DBP, and DBA in relation to curcumin for their ability to suppress TNF-induced NF-κB activation, NF-κB-regulated gene products, and cell proliferation. We found that all four agents were active in suppressing NF-κB activation; curcumin was most active and DBM was least active. When examined for its ability to inhibit the direct DNA binding activity of p65, a subunit of NF-κB, only DBP inhibited the binding. For inhibition of TNF-induced IKK activation, DBA was most active. For suppression of TNF-induced expression of NF-κB-regulated gene products such as COX-2 (inflammation marker), cyclin D1 (proliferation marker), and VEGF (angiogenesis marker), DBA and curcumin were more active than DBM. Similarly for suppression of proliferation of leukemia (KBM-5), T cell leukemia (Jurkat), prostate (DU145), and breast (MDA-MB-231) cancer cells, curcumin and DBA were most active and DBP was least active. Overall, our results indicate that although curcumin and its analogues exhibit activities to suppress inflammatory pathways and cellular proliferation, a lack of Michael acceptor units in DBM and DBP can reduce their activities.

  14. Rindler-like Horizon in Spherically Symmetric Spacetime

    NASA Astrophysics Data System (ADS)

    Yang, Jinbo; He, Tangmei; Zhang, Jingyi

    2016-07-01

    In this paper, the Rindler-like horizon in a spherically symmetric spacetime is proposed. It is showed that just like the Rindler horizon in Minkowski spacetimes, there is also a Rindler-like horizon to a family of special observers in general spherically symmetric spacetimes. The entropy of this type of horizon is calculated with the thin film brick-wall model. The significance of entropy is discussed. Our results imply some connection between Bekeinstein-Hawking entropy and entanglement entropy.

  15. Chiral Aminophosphines as Catalysts for Enantioselective Double-Michael Indoline Syntheses

    PubMed Central

    Khong, San N.; Kwon, Ohyun

    2014-01-01

    The bisphosphine-catalyzed double-Michael addition of dinucleophiles to electron-deficient acetylenes is an efficient process for the synthesis of many nitrogen-containing heterocycles. Because the resulting heterocycles contain at least one stereogenic center, this double-Michael reaction would be even more useful if an asymmetric variant of the reaction were to be developed. Aminophosphines can also facilitate the double-Michael reaction and chiral amines are more readily available in Nature and synthetically; therefore, in this study we prepared several new chiral aminophosphines. When employed in the asymmetric double-Michael reaction between ortho-tosylamidophenyl malonate and 3-butyn-2-one, the chiral aminophosphines produced indolines in excellent yields with moderate asymmetric induction. PMID:22580397

  16. Tandem bis-aza-Michael addition reaction of amines in aqueous medium promoted by polystyrenesulfonic Acid

    EPA Science Inventory

    An efficient and environmentally benign tandem bis-aza-Michael addition of amines catalyzed by polystyrene sulfonic acid (PSSA) is described. This operationally simple high yielding microwave assisted synthetic protocol proceeded in water in the absence of any organic solvent.

  17. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: High Cholesterol High Blood Cholesterol Q&A with Dr. Michael Lauer Past Issues / ... heavier and older, what does recent research on cholesterol and heart health tell us that Americans need ...

  18. Theory and practice in action: the contributions of Michael Perkins to clinical linguistics.

    PubMed

    Damico, Jack S; Lynch, Karen E

    2013-01-01

    This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.

  19. Trimethylsilylethynyl ketones as surrogates for ethynyl ketones in the double Michael reaction.

    PubMed

    Holeman, Derrick S; Rasne, Ravindra M; Grossman, Robert B

    2002-05-01

    Trimethylsilylethynyl ketones can be desilylated in the presence of a tethered carbon diacid and induced to undergo a double Michael reaction in situ. The trimethylsilylethynyl ketones can serve as surrogates of ethynyl ketones that are difficult to prepare or isolate.

  20. Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.

    PubMed

    Krishnan, Shyam; Miller, Rand M; Tian, Boxue; Mullins, R Dyche; Jacobson, Matthew P; Taunton, Jack

    2014-09-10

    Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of acrylonitrile-based Michael acceptors, activated by aryl or heteroaryl electron-withdrawing groups. We demonstrate that thiol adducts of these acrylonitriles undergo β-elimination at rates that span more than 3 orders of magnitude. These rates correlate inversely with the computed proton affinity of the corresponding carbanions, enabling the intrinsic reversibility of the thiol-Michael reaction to be tuned in a predictable manner. We apply these principles to the design of new reversible covalent kinase inhibitors with improved properties. A cocrystal structure of one such inhibitor reveals specific noncovalent interactions between the 1,2,4-triazole activating group and the kinase. Our experimental and computational study enables the design of new Michael acceptors, expanding the palette of reversible, cysteine-targeted electrophiles.

  1. Helical-Peptide-Catalyzed Enantioselective Michael Addition Reactions and Their Mechanistic Insights.

    PubMed

    Ueda, Atsushi; Umeno, Tomohiro; Doi, Mitsunobu; Akagawa, Kengo; Kudo, Kazuaki; Tanaka, Masakazu

    2016-08-01

    Helical peptide foldamer catalyzed Michael addition reactions of nitroalkane or dialkyl malonate to α,β-unsaturated ketones are reported along with the mechanistic considerations of the enantio-induction. A wide variety of α,β-unsaturated ketones, including β-aryl, β-alkyl enones, and cyclic enones, were found to be catalyzed by the helical peptide to give Michael adducts with high enantioselectivities (up to 99%). On the basis of X-ray crystallographic analysis and depsipeptide study, the amide protons, N(2)-H and N(3)-H, at the N terminus in the α-helical peptide catalyst were crucial for activating Michael donors, while the N-terminal primary amine activated Michael acceptors through the formation of iminium ion intermediates.

  2. STS-34 Pilot Michael J. McCulley during T-30 press briefing at JSC

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-34 Atlantis, Orbiter Vehicle (OV) 104, Pilot Michael J. McCulley reflects on a question during the thirty days before launch (T-30) press briefing in the JSC Auditorium and Public Affairs Facility Bldg 2 briefing room.

  3. Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions.

    PubMed

    Shang, Zhuo; Khalil, Zeinab; Li, Li; Salim, Angela A; Quezada, Michelle; Kalansuriya, Pabasara; Capon, Robert J

    2016-09-01

    Cultures of the estuarine fungus Penicillium roseopurpureum (CMB-MF038) yielded a diverse array of polyketides, many of which were related via a highly convergent biosynthetic pathway. In addition to revising and assigning structures, and documenting chemical and biological properties, pro-drug cytotoxic properties were attributed to roseopurpurins H (10) and I (11) on the basis of in situ reverse Michael addition to a cytotoxic Michael acceptor (12). PMID:27537356

  4. A Fresh Wind is Blowing in from Asia Professor Michael Raghunath Arrives at ZHAW Waedenswil.

    PubMed

    Heinzelmann, Elsbeth

    2016-01-01

    In summer 2016, Michael Raghunath from the National University of Singapore (NUS) will take over the professorship from Ursula Graf-Hausner in cell culture technology and tissue engineering at ZHAW Life Sciences and Facility Management. What are his objectives and the corresponding strategies? What challenges will he face, what will he choose to focus on? Michael Raghunath was kind enough to let us have a look behind the scenes. PMID:27363381

  5. Status of the JPL Horizons Ephemeris System

    NASA Astrophysics Data System (ADS)

    Giorgini, Jon D.

    2015-08-01

    Since 1996, the NASA/Jet Propulsion Laboratory on-line Horizons system has provided open access to the latest JPL orbit solutions through customizable ephemeris generation and searches. Currently, high-precision ephemerides for more than 683,000 objects are available: all known solar system bodies, several dozen spacecraft, system barycenters, and some libration points.Since inception, Horizons has produced 150 million ephemeris products in response to 70.4 million connections by 800,000 unique IP addresses. Recent usage is typically 6000 unique users requesting 4,000,000 ephemeris products per month.Horizons is freely accessible without an account and may be used and automated through any of three interfaces: interactive telnet connection, web-browser form, or by sending e-mail command-files.Asteroid and comet ephemerides are numerically integrated on request using JPL's DASTCOM5 database of initial conditions which is kept current by a separate process; as new measurements and discoveries are reported by the Minor Planet Center, they are automatically processed into new JPL orbit solutions. Radar targets and other objects of high interest have their orbit solutions manually examined and updated into the database.For asteroids and comets, SPK files may be dynamically created using Horizons. This is effectively a recording of the integrator output. The binary files may then be efficiently interpolated by user software to exactly reproduce the trajectory without having to duplicate the numerically integrated n-body dynamical model or PPN equations of motion.Other Horizons output is numerical and in the form of plain-text observer, vector, osculating element, and close-approach tables. More than one hundred quantities can be requested in various time-scales and coordinate systems. For asteroids and comets, statistical uncertainties can be mapped to output times to assess position and motion uncertainties.Horizons is consistent with the DE431 solar system solution

  6. Polarimetry with the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Johnson, Michael; Doeleman, Sheperd; Fish, Vincent L.; Plambeck, Richard L.; Marrone, Daniel P.; Kosowsky, Michael; Wardle, John F. C.; Lu, Rusen

    2014-06-01

    The Event Horizon Telescope (EHT) is an effort to develop millimeter and submillimeter VLBI to image nearby black holes at resolutions comparable to their event horizons. Past work with the EHT has measured compact emission on such scales for Sgr A* and M87, and has also measured sub-parsec structure in more distant quasars. Polarimetry with the EHT enables a powerful extension of this work, mapping magnetic field structures via the highly polarized synchrotron emission. Polarization is also an excellent probe of rapid variability, especially for Sgr A*, and can convey rich astrometric information even with incomplete imaging. We report on results from our 2013 campaign, which demonstrate a sharp increase in the linear polarization fraction and variability with increasing baseline, and we demonstrate that current EHT data can potentially achieve microarcsecond relative astrometry of flaring regions on timescales of minutes.

  7. Horizon ratio bound for inflationary fluctuations.

    PubMed

    Dodelson, Scott; Hui, Lam

    2003-09-26

    We demonstrate that the gravity wave background amplitude implies a robust upper bound on the wavelength-to-horizon ratio at the end of inflation: lambda/H(-1) less than or approximately equal e(60), as long as the cosmic energy density does not drop faster than radiation subsequent to inflation. This limit implies that N, the number of e-folds between horizon exit and the end of inflation for wave modes of interest, is less, similar 60 plus a model-dependent factor-for vast classes of slow-roll models, N less than or approximately equal 67. As an example, this bound solidifies the tension between observations of the cosmic microwave background anisotropies and chaotic inflation with a phi(4) potential by closing the escape hatch of large N (<62). PMID:14525296

  8. Dynamical AdS strings across horizons

    DOE PAGES

    Ishii, Takaaki; Murata, Keiju

    2016-03-01

    We examine the nonlinear classical dynamics of a fundamental string in anti-deSitter spacetime. The string is dual to the flux tube between an external quark-antiquark pair in $N = 4$ super Yang-Mills theory. We perturb the string by shaking the endpoints and compute its time evolution numerically. We find that with sufficiently strong perturbations the string continues extending and plunges into the Poincare´ horizon. In the evolution, effective horizons are also dynamically created on the string worldsheet. The quark and antiquark are thus causally disconnected, and the string transitions to two straight strings. The forces acting on the endpoints vanishmore » with a power law whose slope depends on the perturbations. Lastly, the condition for this transition to occur is that energy injection exceeds the static energy between the quark-antiquark pair.« less

  9. Dynamical AdS strings across horizons

    NASA Astrophysics Data System (ADS)

    Ishii, Takaaki; Murata, Keiju

    2016-03-01

    We examine the nonlinear classical dynamics of a fundamental string in anti-de Sitter spacetime. The string is dual to the flux tube between an external quark-antiquark pair in {N}=4 super Yang-Mills theory. We perturb the string by shaking the endpoints and compute its time evolution numerically. We find that with sufficiently strong perturbations the string continues extending and plunges into the Poincaré horizon. In the evolution, effective horizons are also dynamically created on the string worldsheet. The quark and antiquark are thus causally disconnected, and the string transitions to two straight strings. The forces acting on the endpoints vanish with a power law whose slope depends on the perturbations. The condition for this transition to occur is that energy injection exceeds the static energy between the quark-antiquark pair.

  10. Horizon ratio bound for inflationary fluctuations.

    PubMed

    Dodelson, Scott; Hui, Lam

    2003-09-26

    We demonstrate that the gravity wave background amplitude implies a robust upper bound on the wavelength-to-horizon ratio at the end of inflation: lambda/H(-1) less than or approximately equal e(60), as long as the cosmic energy density does not drop faster than radiation subsequent to inflation. This limit implies that N, the number of e-folds between horizon exit and the end of inflation for wave modes of interest, is less, similar 60 plus a model-dependent factor-for vast classes of slow-roll models, N less than or approximately equal 67. As an example, this bound solidifies the tension between observations of the cosmic microwave background anisotropies and chaotic inflation with a phi(4) potential by closing the escape hatch of large N (<62).

  11. Quantum correlations across the black hole horizon

    SciTech Connect

    Schuetzhold, Ralf; Unruh, William G.

    2010-06-15

    Inspired by the condensed-matter analogues of black holes, we study the quantum correlations across the event horizon reflecting the entanglement between the outgoing particles of the Hawking radiation and their in-falling partners. For a perfectly covariant theory, the total correlation is conserved in time and piles up arbitrary close to the horizon in the past, where it merges into the singularity of the vacuum two-point function at the light cone. After modifying the dispersion relation (i.e., breaking Lorentz invariance) for large k, on the other hand, the light cone is smeared out and the entanglement is not conserved but actually created in a given rate per unit time.

  12. New Horizons Pluto Flyby Guest Operations

    NASA Astrophysics Data System (ADS)

    Simon, M.; Turney, D.; Fisher, S.; Carr, S. S.

    2015-12-01

    On July 14, 2015, after 9.5 years of cruise, NASA's New Horizons spacecraft flew past the Pluto system to gather first images humankind had ever seen on Pluto and its five moons. While much has been discovered about the Pluto system since New Horizons launch in 2006, the system has never been imaged at high resolution and anticipation of the "First Light" of the Pluto system had been anticipated by planetary enthusiasts for decades. The Johns Hopkins Applied Physics Laboratory (APL), which built and operates New Horizons, was the focal point for gathering three distinct groups: science and engineering team members; media and public affairs representatives; and invited public, including VIP's. Guest operations activities were focused on providing information primarily to the invited public and VIP's. High level objectives for the Guest Operations team was set to entertain and inform the general public, offer media reaction shots, and to deconflict activities for the guests from media activities wherever possible. Over 2000 people arrived at APL in the days surrounding closest approach for guest, science or media operations tracks. Reaction and coverage of the Guest Operations events was universally positive and global in impact: iconic pictures of the auditorium waving flags during the moment of closest approach were published in media outlets on every continent. Media relations activities ensured coverage in all key media publications targeted for release, such as the New York Times, Science, Le Monde, and Nature. Social and traditional media coverage of the events spanned the globe. Guest operations activities are designed to ensure that a guest has a memorable experience and leaves with a lifelong memory of the mission and their partnership in the activity. Results, lessons learned, and other data from the New Horizons guest operations activity will be presented and analyzed.

  13. Quantum amplification effect in a horizon fluctuation

    SciTech Connect

    Ansari, Mohammad H.

    2010-05-15

    The appearance of a few unevenly spaced bright flashes of light on top of Hawking radiation is the sign of the amplification effect in black hole horizon fluctuations. Previous studies on this problem suffer from the lack of considering all emitted photons in the theoretical spectroscopy of these fluctuations. In this paper, we include all of the physical transition weights and present a consistent intensity formula. This modifies a black hole radiation pattern.

  14. New Horizons Imaging of Jupiter's Main Ring

    NASA Astrophysics Data System (ADS)

    Throop, Henry B.; Showalter, Mark Robert; Dones, Henry C. Luke; Hamilton, D. P.; Weaver, Harold A.; Cheng, Andrew F.; Stern, S. Alan; Young, Leslie; Olkin, Catherine B.; New Horizons Science Team

    2016-10-01

    New Horizons took roughly 520 visible-light images of Jupiter's ring system during its 2007 flyby, using the spacecraft's Long-Range Reconnaissance Imager (LORRI). These observations were taken over nine days surrounding Jupiter close-approach. They span a range in distance of 30 - 100 RJ, and a phase angle range of 20 - 174 degrees. The highest resolution images -- more than 200 frames -- were taken at a resolution approaching 20 km/pix.We will present an analysis of this dataset, much of which has not been studied in detail before. Our results include New Horizons' first quantitative measurements of the ring's intrinsic brightness and variability. We will also present results on the ring's azimuthal and radial structure. Our measurements of the ring's phase curve will be used to infer properties of the ring's dust grains.Our results build on the only previous analysis of the New Horizons Jupiter ring data set, presented in Showalter et al (2007, Science 318, 232-234), which detected ring clumps and placed a lower limit on the population of undetected ring-moons.This work was supported by NASA's OPR program.

  15. Accurate, reliable prototype earth horizon sensor head

    NASA Technical Reports Server (NTRS)

    Schwarz, F.; Cohen, H.

    1973-01-01

    The design and performance is described of an accurate and reliable prototype earth sensor head (ARPESH). The ARPESH employs a detection logic 'locator' concept and horizon sensor mechanization which should lead to high accuracy horizon sensing that is minimally degraded by spatial or temporal variations in sensing attitude from a satellite in orbit around the earth at altitudes in the 500 km environ 1,2. An accuracy of horizon location to within 0.7 km has been predicted, independent of meteorological conditions. This corresponds to an error of 0.015 deg-at 500 km altitude. Laboratory evaluation of the sensor indicates that this accuracy is achieved. First, the basic operating principles of ARPESH are described; next, detailed design and construction data is presented and then performance of the sensor under laboratory conditions in which the sensor is installed in a simulator that permits it to scan over a blackbody source against background representing the earth space interface for various equivalent plant temperatures.

  16. Emergent horizons and causal structures in holography

    NASA Astrophysics Data System (ADS)

    Banerjee, Avik; Kundu, Arnab; Kundu, Sandipan

    2016-09-01

    The open string metric arises kinematically in studying fluctuations of open string degrees of freedom on a D-brane. An observer, living on a probe D-brane, can send signals through the spacetime by using such fluctuations on the probe, that propagate in accordance with a metric which is conformal to the open string metric. Event horizons can emerge in the open string metric when one considers a D-brane with an electric field on its worldvolume. Here, we emphasize the role of and investigate, in details, the causal structure of the resulting open string event horizon and demonstrate, among other things, its close similarities to an usual black hole event horizon in asymptotically AdS-spaces. To that end, we analyze relevant geodesics, Penrose diagrams and various causal holographic observables for a given open string metric. For analytical control, most of our calculations are performed in an asymptotically AdS3-background, however, we argue that the physics is qualitatively the same in higher dimensions. We also discuss how this open string metric arises from an underlying D-brane configuration in string theory.

  17. Gravitational memory charges of supertranslation and superrotation on Rindler horizons

    NASA Astrophysics Data System (ADS)

    Hotta, Masahiro; Trevison, Jose; Yamaguchi, Koji

    2016-10-01

    In a Rindler-type coordinate system spanned in a region outside of a black hole horizon, we have nonvanishing classical holographic charges as soft hairs on the horizon for stationary black holes. Taking a large black hole mass limit, the spacetimes with the charges are described by asymptotic Rindler metrics. We construct a general theory of gravitational holographic charges for a (1 +3 )-dimensional linearized gravity field in the Minkowski background with Rindler horizons. Although matter crossing a Rindler horizon causes horizon deformation and a time-dependent coordinate shift—that is, gravitational memory—the supertranslation and superrotation charges on the horizon can be defined during and after its passage through the horizon. It is generally proven that holographic states on the horizon cannot store any information about absorbed perturbative gravitational waves. However, matter crossing the horizon really excites holographic states. By using gravitational memory operators, which consist of the holographic charge operators, we suggest a resolution of the no-cloning paradox of quantum information between matter falling into the horizon and holographic charges on the horizon from the viewpoint of the contextuality of quantum measurement.

  18. One-pot synthesis of (-)-oseltamivir and mechanistic insights into the organocatalyzed Michael reaction.

    PubMed

    Mukaiyama, Takasuke; Ishikawa, Hayato; Koshino, Hiroyuki; Hayashi, Yujiro

    2013-12-23

    The one-pot sequential synthesis of (-)-oseltamivir has been achieved without evaporation or solvent exchange in 36% yield over seven reactions. The key step was the asymmetric Michael reaction of pentan-3-yloxyacetaldehyde with (Z)-N-2-nitroethenylacetamide, catalyzed by a diphenylprolinol silyl ether. The use of a bulky O-silyl-substituted diphenylprolinol catalyst, chlorobenzene as a solvent, and HCO2 H as an acid additive, were key to produce the first Michael adduct in both excellent yield and excellent diastereo- and enantioselectivity. Investigation into the effect of acid demonstrated that an acid additive accelerates not only the E-Z isomerization of the enamines derived from pentan-3-yloxyacetaldehyde with diphenylprolinol silyl ether, but also ring opening of the cyclobutane intermediate and the addition reaction of the enamine to (Z)-N-2-nitroethenylacetamide. The transition-state model for the Michael reaction of pentan-3-yloxyacetaldehyde with (Z)-N-2-nitroethenylacetamide was proposed by consideration of the absolute configuration of the major and minor isomers of the Michael product with the results of the Michael reaction of pentan-3-yloxyacetaldehyde with phenylmaleimide and naphthoquinone.

  19. Black hole thermodynamics from Euclidean horizon constraints.

    PubMed

    Carlip, S

    2007-07-13

    To explain black hole thermodynamics in quantum gravity, one must introduce constraints to ensure that a black hole is actually present. I show that for a large class of black holes, such "horizon constraints" allow the use of conformal field theory techniques to compute the density of states, reproducing the Bekenstein-Hawking entropy in a nearly model-independent manner. One standard string theory approach to black hole entropy arises as a special case, lending support to the claim that the mechanism may be "universal." I argue that the relevant degrees of freedom are Goldstone-boson-like excitations arising from the weak breaking of symmetry by the constraints. PMID:17678209

  20. Time Horizon and Social Scale in Communication

    NASA Astrophysics Data System (ADS)

    Krantz, D. H.

    2010-12-01

    In 2009 our center (CRED) published a first version of The Psychology of Climate Change Communication. In it, we attempted to summarize facts and concepts from psychological research that could help guide communication. While this work focused on climate change, most of the ideas are at least partly applicable for communication about a variety of natural hazards. Of the many examples in this guide, I mention three. Single-action bias is the human tendency to stop considering further actions that might be needed to deal with a given hazard, once a single action has been taken. Another example is the importance of group affiliation in motivating voluntary contributions to joint action. A third concerns the finding that group participation enhances understanding of probabilistic concepts and promotes action in the face of uncertainty. One current research direction, which goes beyond those included in the above publication, focuses on how time horizons arise in the thinking of individuals and groups, and how these time horizons might influence hazard preparedness. On the one hand, individuals sometimes appear impatient, organizations look for immediate results, and officials fail to look beyond the next election cycle. Yet under some laboratory conditions and in some subcultures, a longer time horizon is adopted. We are interested in how time horizon is influenced by group identity and by the very architecture of planning and decision making. Institutional changes, involving long-term contractual relationships among communities, developers, insurers, and governments, could greatly increase resilience in the face of natural hazards. Communication about hazards, in the context of such long-term contractual relationships might look very different from communication that is first initiated by immediate threat. Another new direction concerns the social scale of institutions and of communication about hazards. Traditionally, insurance contracts share risk among a large

  1. Peripheral Vision Horizon Display (PVHD). Corrected Copy

    NASA Technical Reports Server (NTRS)

    1984-01-01

    A Canadian invention, the peripheral vision horizon display (PVHD), shows promise in alleviating vertigo or disorientation in pilots flying under instrument conditions and easing the piloting task when flying in weather or other conditions requiring close attention to aircraft attitude instruments. A diversity of research and applied work was being done to investigate and validate the benefits of the PVHD during the years immediately preceding this conference. Organizers of the conference were able to assemble a group of outstanding presenters representing academic, industrial, and military. The theoretical foundation and applied use of the PVHD are discussed, and results from operational tests are presented.

  2. Art, the Urban Skyscraper, and Horizon Astronomy

    NASA Astrophysics Data System (ADS)

    Mooney, J. D.

    2016-01-01

    This presentation delineates the historiography and the iconography of my urban public sculptures which use skyscrapers as today's standing stones, markers for horizon astronomy. From 1977 to the present time, my work has engaged the public to “look up and see.” Through ephemeral works in the sky and over the water to large-scale rooftop sculptures in Los Angeles, Chicago, Atlanta, and Europe, viewers are oriented to the Milky Way, the summer triangle, and other celestial phenomena. This new urban scale art, transformative in context and gesture, has become part of the new cultural landscape.

  3. An uneventful horizon in two dimensions

    NASA Astrophysics Data System (ADS)

    Almheiri, Ahmed; Sully, James

    2014-02-01

    We investigate the possibility of firewalls in the Einstein-dilaton gravity model of CGHS. We use the results of the numerical simulation carried out by Ashtekar et al. to demonstrate that firewalls are absent and the horizon is drama free. We show that the lack of a firewall is consistent because the model does not satisfy one of the postulates of black hole complementarity. In particular, we elaborate on previous work showing that the Hawking radiation is not pure, and is completely entangled with a long-lived remnant beyond the last ray.

  4. Astrophysical Black Holes: Evidence of a Horizon?

    NASA Astrophysics Data System (ADS)

    Colpi, Monica

    In this Lecture Note we first follow a short account of the history of the black hole hypothesis. We then review on the current status of the search for astrophysical black holes with particular attention to the black holes of stellar origin. Later, we highlight a series of observations that reveal the albeit indirect presence of supermassive black holes in galactic nuclei, with mention to forthcoming experiments aimed at testing directly the black hole hypothesis. We further focus on evidences of a black hole event horizon in cosmic sources.

  5. European scientists' proposals for HORIZON 2000+

    NASA Astrophysics Data System (ADS)

    1994-10-01

    This programme, which has been given the name Horizon 2000+, will be presented to the press at 0900h on Monday 17 October 1994 at ESA Headquarters in Paris by Professor Lodewijk Woltjer, who chaired the committee of European scientific community representatives set up to consider the proposals submitted, and Professor Roger Bonnet, ESA's Science Programme Director. Journalists wishing to attend this press breakfast are requested to complete and return the attached form, if possible by fax: (33.1) 42.73.76.90.

  6. Black hole thermodynamics from Euclidean horizon constraints.

    PubMed

    Carlip, S

    2007-07-13

    To explain black hole thermodynamics in quantum gravity, one must introduce constraints to ensure that a black hole is actually present. I show that for a large class of black holes, such "horizon constraints" allow the use of conformal field theory techniques to compute the density of states, reproducing the Bekenstein-Hawking entropy in a nearly model-independent manner. One standard string theory approach to black hole entropy arises as a special case, lending support to the claim that the mechanism may be "universal." I argue that the relevant degrees of freedom are Goldstone-boson-like excitations arising from the weak breaking of symmetry by the constraints.

  7. Generic isolated horizons and their applications

    PubMed

    Ashtekar; Beetle; Dreyer; Fairhurst; Krishnan; Lewandowski; Wisniewski

    2000-10-23

    The notion of isolated horizons is extended to allow for distortion and rotation. Space-times containing a black hole, itself in equilibrium but possibly surrounded by radiation, satisfy these conditions. The framework has three types of applications: (i) it provides new tools to extract physics from strong field geometry; (ii) it leads to a generalization of the zeroth and first laws of black hole mechanics and sheds new light on the "origin" of the first law; and (iii) it serves as a point of departure for black hole entropy calculations in nonperturbative quantum gravity. PMID:11030951

  8. Prolate horizons and the Penrose inequality

    SciTech Connect

    Tippett, Benjamin K.

    2009-05-15

    The Penrose inequality has so far been proven in cases of spherical symmetry and in cases of zero extrinsic curvature. The next simplest case worth exploring would be nonspherical, nonrotating black holes with nonzero extrinsic curvature. Following Karkowski et al.'s construction of prolate black holes, we define initial data on an asymptotically flat spacelike 3-surface with nonzero extrinsic curvature that may be chosen freely. This gives us the freedom to define the location of the apparent horizon such that the Penrose inequality is violated. We show that the dominant energy condition is violated at the poles for all cases considered.

  9. In Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.

    PubMed

    Duplan, Vincent; Hoshino, Manabu; Li, Wei; Honda, Tadashi; Fujita, Makoto

    2016-04-11

    A reversible Michael addition reaction between thiol nucleophiles and cyanoenones has been previously postulated to be the mechanism-of-action of a new family of reversible covalent drugs. However, the hypothetical Michael adducts in this mechanism have only been detected by spectroscopic methods in solution. Herein, the crystallographic observation of reversible Michael addition with a potent cyanoenone drug candidate by means of the crystalline-sponge method is reported. After inclusion of the cyanoenone substrate, the sponge crystal was treated with a thiol solution. Subsequent crystallographic analysis confirmed the single-crystal-to-single-crystal transformation of the substrate into the impermanent Michael adduct.

  10. TUTORIAL ON NETWORK GENOMICS.

    SciTech Connect

    Forst, C.

    2001-01-01

    With the ever-increasing genomic information pouring into the databases researchers start to look for pattern in genomes. Key questions are the identification of function. In the past function was mainly understood to be assigned to a single gene isolated from other cellular components or mechanisms. Sequence comparison fo single genes and their products (proteins) as well as of intergenic space are a consequence of a well established one-gene one-function interpretation. prediction of function solely by sequence similarity searches are powerful techniques that initiated the advent of bioinformatics and computational biology. Seminal work on sequence alignment by Temple Smith and Michael Waterman [33] and sequence searches with the BLAST algorithm by Altschul et al. [2] provide essential methods for sequence based determination of function. Similar outstanding contributions to determination of function have been archived in the area of structure prediction, molecular modeling and molecular dynamics. Techniques covering ab initio and homology modeling up to biophysical interpretation of long-run molecular dynamics simulations are mentioned ehre. With the ever-increasing number of information of different genetic/genomic origin, new aspect are looked for that deviate from the single gene at a time method. Especially with the identification of surprisingly few human genes the emerging perception in the scientific community that the concept of function has to be extended to include other sequence based as well as non-sequenced based information. A schema of determination of function by different concepts is shown in Figure 1. The tutorial is comprised of the following sections: The first two sections discuss the differences between genomic and non-genomic based context information, section three will cover combined methods. Finally, section four lsits web-resources and databases. All presented approaches extensively employ comparative methods.

  11. X-24B with Test Pilot Michael V. Love

    NASA Technical Reports Server (NTRS)

    1973-01-01

    This photo shows Air Force Lieutenant Colonel Michael V. Love in front of the X-24B lifting-body research vehicle at Edwards Air Force Base in 1973. Love was assigned as a project pilot on the joint NASA-USAF X-24B Lifting Body flight test program at the NASA Flight Research Center. He made a total of 12 flights in the plane from October 4, 1973 until July 15, 1975. Love flew it to a speed of Mach 1.76 on October 25, 1974, a record for the X-24B. Love attended the USAF Test Pilot School and remained as an instructor there from 1969 through 1971. He was a test pilot at Edwards when assigned to fly to the X-24B. Love was a combat veteran of Vietnam and was awarded the Distinguished Flying Cross with two Oak Leaf clusters. Love perished while attempting an emergency landing in an RF-4C on March 1, 1976. The X-24B was the last aircraft to fly in the Dryden Flight Research Center's manned lifting body program. The X-24 was one of a group of lifting bodies flown by the NASA Flight Research Center (now Dryden Flight Research Center), Edwards, California, in a joint program with the U.S. Air Force at Edwards Air Force Base from 1963 to 1975. The lifting bodies were used to demonstrate the ability of pilots to maneuver and safely land wingless vehicles designed to fly back to Earth from space and be landed like an airplane at a predetermined site. Lifting bodies' aerodynamic lift, essential to flight in the atmosphere, was obtained from their shape. The addition of fins and control surfaces allowed the pilots to stabilize and control the vehicles and regulate their flight paths. Built by Martin Aircraft Company, Maryland, for the U.S. Air Force, the X-24A was a bulbous vehicle shaped like a teardrop with three vertical fins at the rear for directional control. It weighed 6,270 pounds, was 24.5 feet long and 11.5 feet wide (measuring just the fuselage, not the distance between the tips of the outboard fins). Its first unpowered glide flight was on April 17, 1969, with Air

  12. A general overview of the organocatalytic intramolecular aza-Michael reaction.

    PubMed

    Sánchez-Roselló, María; Aceña, José Luis; Simón-Fuentes, Antonio; del Pozo, Carlos

    2014-11-01

    The organocatalytic intramolecular aza-Michael reaction gives access to enantiomerically enriched nitrogen-containing heterocycles in a very simple manner. Enals, enones, conjugated esters and nitro olefins have been employed as Michael acceptors, while moderate nitrogen nucleophiles such as sulphonamides, carbamates and amides have been shown to be appropriate Michael donors in this type of reaction. Additionally, the process has been performed under both covalent and non-covalent catalysis, with diaryl prolinols, imidazolidinones, thioureas and chiral binol phosphoric acids being the most frequently used catalysts. The level of efficiency reached with this protocol is demonstrated by the implementation of numerous tandem processes, as well as the total synthesis of several natural products.

  13. Dynamical horizons: energy, angular momentum, fluxes, and balance laws.

    PubMed

    Ashtekar, Abhay; Krishnan, Badri

    2002-12-23

    Dynamical horizons are considered in full, nonlinear general relativity. Expressions of fluxes of energy and angular momentum carried by gravitational waves across these horizons are obtained. Fluxes are local, the energy flux is positive, and change in the horizon area is related to these fluxes. The flux formulas also give rise to balance laws analogous to the ones obtained by Bondi and Sachs at null infinity and provide generalizations of the first and second laws of black-hole mechanics. PMID:12484807

  14. Radiation from quantum weakly dynamical horizons in loop quantum gravity.

    PubMed

    Pranzetti, Daniele

    2012-07-01

    We provide a statistical mechanical analysis of quantum horizons near equilibrium in the grand canonical ensemble. By matching the description of the nonequilibrium phase in terms of weakly dynamical horizons with a local statistical framework, we implement loop quantum gravity dynamics near the boundary. The resulting radiation process provides a quantum gravity description of the horizon evaporation. For large black holes, the spectrum we derive presents a discrete structure which could be potentially observable.

  15. Oil sheen weathering post Deepwater Horizon

    NASA Astrophysics Data System (ADS)

    Kellermann, M. Y.; Redmond, M. C.; Reddy, C. M.; Aeppli, C.; Nelson, R. K.; Valentine, D. L.

    2013-12-01

    A recently published study identified the source of the reoccurred oil sheens close to the Deepwater Horizon (DWH) disaster site as a finite contamination most likely derived from tanks and pits on the DWH wreckage itself. Here we use geochemical fingerprinting and microbial community analysis to better understand the fate and weathering processes affecting these surface oils. Both, alkanes and polycyclic aromatic hydrocarbons (PAHs) are shown to reflect a linear decrease of hydrocarbon compounds with increasing distance to the DWH wreckage site (equivalent to exposure time on the sea surface). These results indicate that in the early stage of weathering the combined effects of dissolution and evaporation dominate the degradation of these surface oils. Sheen microbial communities were dominated by Cyanobacteria, Planctomycetes, Verrucomicrobia, Flavobacteria, Alphaproteobacteria, and Deltaproteobacteria, with low relative abundances of Gammaproteobacteria likely to be hydrocarbon degraders (no more than 15% of sequences in each sample). However, some of these Gammaproteobacteria were closely related to putative hydrocarbon degraders observed in abundance in deep water plumes during the primary Deepwater Horizon spill, suggesting that very low levels of biodegradation may be also occurring. This in situ weathering experiment provides new insights in hydrocarbon weathering dynamics and shows how chemical and biological changes can potentially be masked by large evaporative losses of compounds smaller than C18 n-alkanes.

  16. Gribov's horizon and the ghost dressing function

    SciTech Connect

    Boucaud, Ph.; Leroy, J. P.; Le Yaouanc, A.; Micheli, J.; Pene, O.; Rodriguez-Quintero, J.

    2009-11-01

    We study a relation recently derived by K. Kondo at zero momentum between the Zwanziger's horizon function, the ghost dressing function and Kugo's functions u and w. We agree with this result as far as bare quantities are considered. However, assuming the validity of the horizon gap equation, we argue that the solution w(0)=0 is not acceptable since it would lead to a vanishing renormalized ghost dressing function. On the contrary, when the cutoff goes to infinity, u(0){yields}{infinity}, w(0){yields}-{infinity} such that u(0)+w(0){yields}-1. Furthermore w and u are not multiplicatively renormalizable. Relaxing the gap equation allows w(0)=0 with u(0){yields}-1. In both cases the bare ghost dressing function, F(0,{lambda}), goes logarithmically to infinity at infinite cutoff. We show that, although the lattice results provide bare results not so different from the F(0,{lambda})=3 solution, this is an accident due to the fact that the lattice cutoffs lie in the range 1-3 GeV{sup -1}. We show that the renormalized ghost dressing function should be finite and nonzero at zero momentum and can be reliably estimated on the lattice up to powers of the lattice spacing; from published data on a 80{sup 4} lattice at {beta}=5.7 we obtain F{sub R}(0,{mu}=1.5 GeV){approx_equal}2.2.

  17. Energy and information near black hole horizons

    NASA Astrophysics Data System (ADS)

    Freivogel, Ben

    2014-07-01

    The central challenge in trying to resolve the firewall paradox is to identify excitations in the near-horizon zone of a black hole that can carry information without injuring a freely falling observer. By analyzing the problem from the point of view of a freely falling observer, I arrive at a simple proposal for the degrees of freedom that carry information out of the black hole. An infalling observer experiences the information-carrying modes as ingoing, negative energy excitations of the quantum fields. In these states, freely falling observers who fall in from infinity do not encounter a firewall, but freely falling observers who begin their free fall from a location close to the horizon are ``frozen'' by a flux of negative energy. When the black hole is ``mined,'' the number of information-carrying modes increases, increasing the negative energy flux in the infalling frame without violating the equivalence principle. Finally, I point out a loophole in recent arguments that an infalling observer must detect a violation of unitarity, effective field theory, or free infall.

  18. Cool horizons lead to information loss

    NASA Astrophysics Data System (ADS)

    Chowdhury, Borun D.

    2013-10-01

    There are two evidences for information loss during black hole evaporation: (i) a pure state evolves to a mixed state and (ii) the map from the initial state to final state is non-invertible. Any proposed resolution of the information paradox must address both these issues. The firewall argument focuses only on the first and this leads to order one deviations from the Unruh vacuum for maximally entangled black holes. The nature of the argument does not extend to black holes in pure states. It was shown by Avery, Puhm and the author that requiring the initial state to final state map to be invertible mandates structure at the horizon even for pure states. The proof works if black holes can be formed in generic states and in this paper we show that this is indeed the case. We also demonstrate how models proposed by Susskind, Papadodimas et al. and Maldacena et al. end up making the initial to final state map non-invertible and thus make the horizon "cool" at the cost of unitarity.

  19. Optimal investment horizons for stocks and markets

    NASA Astrophysics Data System (ADS)

    Johansen, A.; Simonsen, I.; Jensen, M. H.

    2006-10-01

    The inverse statistics is the distribution of waiting times needed to achieve a predefined level of return obtained from (detrended) historic asset prices [I. Simonsen, M.H. Jensen, A. Johansen, Eur. Phys. J. 27 (2002) 583; M.H. Jensen, A. Johansen, I. Simonsen, Physica A 234 (2003) 338]. Such a distribution typically goes through a maximum at a time coined the optimal investment horizon, τρ*, which defines the most likely waiting time for obtaining a given return ρ. By considering equal positive and negative levels of return, we reported in [M.H. Jensen, A. Johansen, I. Simonsen, Physica A 234 (2003) 338] on a quantitative gain/loss asymmetry most pronounced for short horizons. In the present paper, the inverse statistics for {2}/{3} of the individual stocks presently in the DJIA is investigated. We show that this gain/loss asymmetry established for the DJIA surprisingly is not present in the time series of the individual stocks nor their average. This observation points towards some kind of collective movement of the stocks of the index (synchronization).

  20. Extended symmetries at the black hole horizon

    NASA Astrophysics Data System (ADS)

    Donnay, Laura; Giribet, Gaston; González, Hernán A.; Pino, Miguel

    2016-09-01

    We prove that non-extremal black holes in four-dimensional general relativity exhibit an infinite-dimensional symmetry in their near horizon region. By prescribing a physically sensible set of boundary conditions at the horizon, we derive the algebra of asymptotic Killing vectors, which is shown to be infinite-dimensional and includes, in particular, two sets of supertranslations and two mutually commuting copies of the Witt algebra. We define the surface charges associated to the asymptotic diffeomorphisms that preserve the boundary conditions and discuss the subtleties of this definition, such as the integrability conditions and the correct definition of the Dirac brackets. When evaluated on the stationary solutions, the only non-vanishing charges are the zero-modes. One of them reproduces the Bekenstein-Hawking entropy of Kerr black holes. We also study the extremal limit, recovering the NHEK geometry. In this singular case, where the algebra of charges and the integrability conditions get modified, we find that the computation of the zero-modes correctly reproduces the black hole entropy. Furthermore, we analyze the case of three spacetime dimensions, in which the integrability conditions notably simplify and the field equations can be solved analytically to produce a family of exact solutions that realize the boundary conditions explicitly. We examine other features, such as the form of the algebra in the extremal limit and the relation to other works in the literature.

  1. Energy and information near black hole horizons

    SciTech Connect

    Freivogel, Ben

    2014-07-01

    The central challenge in trying to resolve the firewall paradox is to identify excitations in the near-horizon zone of a black hole that can carry information without injuring a freely falling observer. By analyzing the problem from the point of view of a freely falling observer, I arrive at a simple proposal for the degrees of freedom that carry information out of the black hole. An infalling observer experiences the information-carrying modes as ingoing, negative energy excitations of the quantum fields. In these states, freely falling observers who fall in from infinity do not encounter a firewall, but freely falling observers who begin their free fall from a location close to the horizon are ''frozen'' by a flux of negative energy. When the black hole is ''mined,'' the number of information-carrying modes increases, increasing the negative energy flux in the infalling frame without violating the equivalence principle. Finally, I point out a loophole in recent arguments that an infalling observer must detect a violation of unitarity, effective field theory, or free infall.

  2. Michael addition reactions for the modification of gold nanoparticles facilitated by hyperbaric conditions.

    PubMed

    Hartlen, Kurtis D; Ismaili, Hossein; Zhu, Jun; Workentin, Mark S

    2012-01-10

    The chemical interfacial modification of organic solvent soluble 2.4 ± 0.5 nm maleimide-modified monolayer protected gold nanoparticles (2-C(12)AuNPs) with primary or secondary amines via Michael addition reactions is demonstrated. Michael addition reactions between 2-C(12)AuNPs and primary or secondary amines at ambient temperature and pressure and under the conditions where the AuNP is soluble and stable are possible albeit sluggish, often taking days to weeks to go to completion. The rates and efficacies of the these same reactions are drastically increased at hyperbaric pressure conditions (11 000 atm) with no observed adverse effect to the gold nanoparticle stability. The resulting Michael addition adducts (3-C(12)AuNPs) formed from 2-C(12)AuNPs and the corresponding amines were characterized by TEM and by comparison of the (1)H NMR spectra of the 3-C(12)AuNPs with those of model reactions of the same amines with N-dodecylmaleimide, 2. The Michael addition reactions occur more readily with 2 rather than 2-C(12)AuNPs, consistent with the local environment of the latter imposing additional steric or other barriers to the reaction. The use of hyperbaric conditions makes the reaction of the organic solvent soluble 2-C(12)AuNP via Michael addition a viable interfacial modification process that is otherwise impractical. The results also suggest that it is a useful protocol for facilitating Michael addition reactions generally in solution at low temperatures.

  3. 'The televising of science is a process of television': establishing Horizon, 1962-1967.

    PubMed

    Boon, Timothy

    2015-03-01

    BBC Television's Horizon series, fifty years old on 2 May 2014, despite its significance to the history of the public culture of science, has been little studied. This microhistorical account follows the gestation and early years of the programme, demonstrating how it established a social and cultural account of science. This was a result of televisual factors, notably the determination to follow the format of the successful arts television programme Monitor. It illuminates how the processes of television production, with a handful of key participants - Aubrey Singer, Gerald Leach, Philip Daly, Gordon Rattray Taylor, Ramsay Short, Michael Peacock and Robert Reid - established the format of the programme. This occurred over seventeen months of prior preparation followed by three troubled years of seeking to establish a stable form. This was finally achieved in 1967 when the programme adopted a film documentary approach after extended attempts at making it as a studio-based magazine programme. The story has implications for understanding the social accounts of science that were circulating in the key decade of the 1960s. PMID:25833799

  4. Cosmic censorship: Formation of a shielding horizon around a fragile horizon

    NASA Astrophysics Data System (ADS)

    Hod, Shahar

    2013-01-01

    The weak cosmic censorship conjecture asserts that spacetime singularities that arise in gravitational collapse are always hidden inside of black holes, invisible to distant observers. This conjecture, put forward by Penrose more than four decades ago, is widely believed to be one of the basic principles of nature. However, a complete proof of this hypothesis is still lacking and the validity of the conjecture has therefore remained one of the most important open questions in general relativity. In this study we analyze a gedanken experiment that is designed to challenge cosmic censorship by trying to overcharge a Reissner-Nordström black hole: a charged shell is lowered adiabatically into the charged black hole. The mass energy delivered to the black hole can be redshifted by letting the dropping point of the shell approach the black-hole horizon. On the other hand, the electric charge of the shell is not redshifted by the gravitational field of the black hole. It therefore seems, at first sight, that the charged shell is not hindered from entering the black hole, overcharging it and removing its horizon. However, in the present study we prove that the exposure of a naked singularity to distant observers is actually excluded due to the formation of a new (and larger) horizon around the original black hole. Moreover, we shall prove that this new horizon is already formed before the charged shell crosses the original black-hole horizon. This result, which seems to have been previously overlooked, guarantees the validity of the weak cosmic censorship conjecture in this type of gedanken experiments.

  5. Criticality and surface tension in rotating horizon thermodynamics

    NASA Astrophysics Data System (ADS)

    Hansen, Devin; Kubizňák, David; Mann, Robert B.

    2016-08-01

    We study a modified horizon thermodynamics and the associated criticality for rotating black hole spacetimes. Namely, we show that under a virtual displacement of the black hole horizon accompanied by an independent variation of the rotation parameter, the radial Einstein equation takes a form of a ‘cohomogeneity two’ horizon first law, δ E=Tδ S+{{Ω }}δ J-σ δ A, where E and J are the horizon energy (an analogue of the Misner-Sharp mass) and the horizon angular momentum, Ω is the horizon angular velocity, A is the horizon area, and σ is the surface tension induced by the matter fields. For fixed angular momentum, the above equation simplifies and the more familiar (cohomogeneity one) horizon first law δ E=Tδ S-Pδ V is obtained, where P is the pressure of matter fields and V is the horizon volume. A universal equation of state is obtained in each case and the corresponding critical behavior is studied.

  6. Horizons versus singularities in spherically symmetric space-times

    SciTech Connect

    Bronnikov, K. A.; Elizalde, E.; Odintsov, S. D.; Zaslavskii, O. B.

    2008-09-15

    We discuss different kinds of Killing horizons possible in static, spherically symmetric configurations and recently classified as 'usual', 'naked', and 'truly naked' ones depending on the near-horizon behavior of transverse tidal forces acting on an extended body. We obtain the necessary conditions for the metric to be extensible beyond a horizon in terms of an arbitrary radial coordinate and show that all truly naked horizons, as well as many of those previously characterized as naked and even usual ones, do not admit an extension and therefore must be considered as singularities. Some examples are given, showing which kinds of matter are able to create specific space-times with different kinds of horizons, including truly naked ones. Among them are fluids with negative pressure and scalar fields with a particular behavior of the potential. We also discuss horizons and singularities in Kantowski-Sachs spherically symmetric cosmologies and present horizon regularity conditions in terms of an arbitrary time coordinate and proper (synchronous) time. It turns out that horizons of orders 2 and higher occur in infinite proper times in the past or future, but one-way communication with regions beyond such horizons is still possible.

  7. Gravitational anomaly and Hawking radiation near a weakly isolated horizon

    SciTech Connect

    Wu Xiaoning; Huang Chaoguang; Sun Jiarui

    2008-06-15

    Based on the idea of the work by Wilczek and his collaborators, we consider the gravitational anomaly near a weakly isolated horizon. We find that there exists a universal choice of tortoise coordinate for any weakly isolated horizon. Under this coordinate, the leading behavior of a quite arbitrary scalar field near a horizon is a 2-dimensional chiral scalar field. This means we can extend the idea of Wilczek and his collaborators to more general cases and show the relation between gravitational anomaly and Hawking radiation is a universal property of a black hole horizon.

  8. Gravitational anomaly and Hawking radiation near a weakly isolated horizon

    NASA Astrophysics Data System (ADS)

    Wu, Xiaoning; Huang, Chao-Guang; Sun, Jia-Rui

    2008-06-01

    Based on the idea of the work by Wilczek and his collaborators, we consider the gravitational anomaly near a weakly isolated horizon. We find that there exists a universal choice of tortoise coordinate for any weakly isolated horizon. Under this coordinate, the leading behavior of a quite arbitrary scalar field near a horizon is a 2-dimensional chiral scalar field. This means we can extend the idea of Wilczek and his collaborators to more general cases and show the relation between gravitational anomaly and Hawking radiation is a universal property of a black hole horizon.

  9. Criticality and surface tension in rotating horizon thermodynamics

    NASA Astrophysics Data System (ADS)

    Hansen, Devin; Kubizňák, David; Mann, Robert B.

    2016-08-01

    We study a modified horizon thermodynamics and the associated criticality for rotating black hole spacetimes. Namely, we show that under a virtual displacement of the black hole horizon accompanied by an independent variation of the rotation parameter, the radial Einstein equation takes a form of a ‘cohomogeneity two’ horizon first law, δ E=Tδ S+{{Ω }}δ J-σ δ A, where E and J are the horizon energy (an analogue of the Misner–Sharp mass) and the horizon angular momentum, Ω is the horizon angular velocity, A is the horizon area, and σ is the surface tension induced by the matter fields. For fixed angular momentum, the above equation simplifies and the more familiar (cohomogeneity one) horizon first law δ E=Tδ S-Pδ V is obtained, where P is the pressure of matter fields and V is the horizon volume. A universal equation of state is obtained in each case and the corresponding critical behavior is studied.

  10. Distributed Fusion Receding Horizon Filtering in Linear Stochastic Systems

    NASA Astrophysics Data System (ADS)

    Song, IlYoung; Kim, DuYong; Kim, YongHoon; Lee, SukJae; Shin, Vladimir

    2009-12-01

    This paper presents a distributed receding horizon filtering algorithm for multisensor continuous-time linear stochastic systems. Distributed fusion with a weighted sum structure is applied to local receding horizon Kalman filters having different horizon lengths. The fusion estimate of the state of a dynamic system represents the optimal linear fusion by weighting matrices under the minimum mean square error criterion. The key contribution of this paper lies in the derivation of the differential equations for determining the error cross-covariances between the local receding horizon Kalman filters. The subsequent application of the proposed distributed filter to a linear dynamic system within a multisensor environment demonstrates its effectiveness.

  11. [Michael Lazarevich Gershanovich--one of the founders of cancer chemotherapy in Russia].

    PubMed

    Semiglazova, T Iu; Filatova, L V; Stukov, A N

    2014-01-01

    Michael Lazarevich Gershanovich was born 90 years ago. He has made a significant contribution to foundation and development of chemotherapy for malignant tumors. Doctor of Medical Sciences, Professor, Laureate of the State Prize of the Russian Federation, Honored Scientist of the Russian Federation, Academician of the Russian Academy of Natural Sciences, a member of the Editorial Board of the Journal "Problems in Oncology" ("Voprosy Onkologii), member of the World Club of Petersburgians, a retired lieutenant-colonel Michael Lazarevich, until his last day (16.12.2013), was the head of the Department of Medical Oncology of the N.N.Petrov Research Institute of Oncology, St. Petersburg. PMID:25552077

  12. Michael addition/pericyclization/rearrangement--a multicomponent strategy for the synthesis of substituted resorcinols.

    PubMed

    Liu, Yu; Doyle, Michael P

    2012-08-21

    The combination of methyl 3,7-dioxo-2-diazo-4-octenoate from the zinc triflate catalyzed Mukaiyama-Michael reaction of methyl 3-tert-butylsilyloxy-2-diazobutenoate and 4-methoxy-3-buten-2-one with Michael acceptors (methyl vinyl ketone, N-phenylmaleimide, β-nitrovinylarenes) in the presence of a catalytic amount of base provides convenient access to highly substituted resorcinol derivatives. This transformation is achieved in an efficient one-pot multi-component transformation by the sequential addition of the reagents.

  13. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors

    PubMed Central

    Schmid, Thibault E; Drissi-Amraoui, Sammy; Crévisy, Christophe; Baslé, Olivier

    2015-01-01

    Summary The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field. PMID:26734090

  14. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors.

    PubMed

    Schmid, Thibault E; Drissi-Amraoui, Sammy; Crévisy, Christophe; Baslé, Olivier; Mauduit, Marc

    2015-01-01

    The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field.

  15. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions.

    PubMed

    Bosica, Giovanna; Abdilla, Roderick

    2016-06-22

    Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  16. Overview of the New Horizons Science Payload

    NASA Astrophysics Data System (ADS)

    Weaver, H. A.; Gibson, W. C.; Tapley, M. B.; Young, L. A.; Stern, S. A.

    2008-10-01

    The New Horizons mission was launched on 2006 January 19, and the spacecraft is heading for a flyby encounter with the Pluto system in the summer of 2015. The challenges associated with sending a spacecraft to Pluto in less than 10 years and performing an ambitious suite of scientific investigations at such large heliocentric distances (>32 AU) are formidable and required the development of lightweight, low power, and highly sensitive instruments. This paper provides an overview of the New Horizons science payload, which is comprised of seven instruments. Alice provides moderate resolution (˜3 10 Å FWHM), spatially resolved ultraviolet (˜465 1880 Å) spectroscopy, and includes the ability to perform stellar and solar occultation measurements. The Ralph instrument has two components: the Multicolor Visible Imaging Camera (MVIC), which performs panchromatic (400 975 nm) and color imaging in four spectral bands (Blue, Red, CH4, and NIR) at a moderate spatial resolution of 20 μrad/pixel, and the Linear Etalon Imaging Spectral Array (LEISA), which provides spatially resolved (62 μrad/pixel), near-infrared (1.25 2.5 μm), moderate resolution ( λ/ δ λ˜240 550) spectroscopic mapping capabilities. The Radio Experiment (REX) is a component of the New Horizons telecommunications system that provides both radio (X-band) solar occultation and radiometry capabilities. The Long Range Reconnaissance Imager (LORRI) provides high sensitivity ( V<18), high spatial resolution (5 μrad/pixel) panchromatic optical (350 850 nm) imaging capabilities that serve both scientific and optical navigation requirements. The Solar Wind at Pluto (SWAP) instrument measures the density and speed of solar wind particles with a resolution Δ E/ E<0.4 for energies between 25 eV and 7.5 keV. The Pluto Energetic Particle Spectrometer Science Investigation (PEPSSI) measures energetic particles (protons and CNO ions) in 12 energy channels spanning 1 1000 keV. Finally, an instrument designed and

  17. Empirical correction for earth sensor horizon radiance variation

    NASA Technical Reports Server (NTRS)

    Hashmall, Joseph A.; Sedlak, Joseph; Andrews, Daniel; Luquette, Richard

    1998-01-01

    A major limitation on the use of infrared horizon sensors for attitude determination is the variability of the height of the infrared Earth horizon. This variation includes a climatological component and a stochastic component of approximately equal importance. The climatological component shows regular variation with season and latitude. Models based on historical measurements have been used to compensate for these systematic changes. The stochastic component is analogous to tropospheric weather. It can cause extreme, localized changes that for a period of days, overwhelm the climatological variation. An algorithm has been developed to compensate partially for the climatological variation of horizon height and at least to mitigate the stochastic variation. This method uses attitude and horizon sensor data from spacecraft to update a horizon height history as a function of latitude. For spacecraft that depend on horizon sensors for their attitudes (such as the Total Ozone Mapping Spectrometer-Earth Probe-TOMS-EP) a batch least squares attitude determination system is used. It is assumed that minimizing the average sensor residual throughout a full orbit of data results in attitudes that are nearly independent of local horizon height variations. The method depends on the additional assumption that the mean horizon height over all latitudes is approximately independent of season. Using these assumptions, the method yields the latitude dependent portion of local horizon height variations. This paper describes the algorithm used to generate an empirical horizon height. Ideally, an international horizon height database could be established that would rapidly merge data from various spacecraft to provide timely corrections that could be used by all.

  18. Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes.

    PubMed

    Chen, Jia-Rong; Fu, Liang; Zou, You-Quan; Chang, Ning-Jie; Rong, Jian; Xiao, Wen-Jing

    2011-07-21

    A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).

  19. Decarboxylative 1,4-Addition of α-Oxocarboxylic Acids with Michael Acceptors Enabled by Photoredox Catalysis.

    PubMed

    Wang, Guang-Zu; Shang, Rui; Cheng, Wan-Min; Fu, Yao

    2015-10-01

    Enabled by iridium photoredox catalysis, 2-oxo-2-(hetero)arylacetic acids were decarboxylatively added to various Michael acceptors including α,β-unsaturated ester, ketone, amide, aldehyde, nitrile, and sulfone at room temperature. The reaction presents a new type of acyl Michael addition using stable and easily accessible carboxylic acid to formally generate acyl anion through photoredox-catalyzed radical decarboxylation. PMID:26366608

  20. 78 FR 66970 - In the Matter of Michael J. Buhrman; Order Prohibiting Involvement in NRC-Licensed Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-07

    ... be filed in accordance with the NRC E-Filing rule (72 FR 49139, August 28, 2007). The E-Filing... COMMISSION In the Matter of Michael J. Buhrman; Order Prohibiting Involvement in NRC-Licensed Activities (Effective Immediately) I. Michael J. Buhrman was formerly employed as a senior reactor operator (SRO) at...

  1. 76 FR 44901 - Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v..., Californians for Renewable Energy, Inc. (CARE), acting on behalf of its members, Michael E. Boyd, and Robert...

  2. 78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program....'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form...

  3. 77 FR 40878 - Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. California Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey... Utility Regulatory Policies Act of 1978 (PURPA), Californians for Renewable Energy, Inc., Michael E....

  4. 76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF VETERANS AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program.... 2900-New (VA Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael...

  5. The High Intensity Horizon at Fermilab

    SciTech Connect

    Tschirhart, R.S.; /Fermilab

    2012-05-01

    Fermilab's high intensity horizon is 'Project-X' which is a US led initiative with strong international participation that aims to realize a next generation proton source that will dramatically extend the reach of Intensity Frontier research. The Project-X research program includes world leading sensitivity in long-baseline and short-baseline neutrino experiments, a rich program of ultra-rare muon and kaon decays, opportunities for next-generation electric dipole moment experiments and other nuclear/particle physics probes, and a platform to investigate technologies for next generation energy applications. A wide range of R&D activities has supported mission critical accelerator subsystems, such as high-gradient superconducting RF accelerating structures, efficient RF power systems, cryo-modules and cryogenic refrigeration plants, advanced beam diagnostics and instrumentation, high-power targetry, as well as the related infrastructure and civil construction preparing for a construction start of a staged program as early as 2017.

  6. Black Hole Observations - Towards the Event Horizon

    NASA Astrophysics Data System (ADS)

    Britzen, Silke

    Black Holes are probably the most elusive solutions of Einstein's theory of General Relativity. Despite numerous observations of the direct galactic environment and indirect influence of astrophysical black holes (e.g. jets, variable emission across the wavelength spectrum, feedback processes, etc.) -- a direct proof of their existence is still lacking. This article highlights some aspects deduced from many observations and concentrates on the experimental results with regard to black holes with masses from millions to billions of solar masses. The focus will be on the challenges and remaining questions. The Event Horizon Telescopce (EHT) project to image the photon sphere of Sgr A* and its potential is briefly sketched. This instrumental approach shall lead to highest resolution observations of the supermassive black hole at the center of the Milky Way (Sgr A*).

  7. Opportunity Spies 'Endurance' on the Horizon

    NASA Technical Reports Server (NTRS)

    2004-01-01

    This image taken by the Mars Exploration Rover Opportunity's panoramic camera shows the eastern plains that stretch beyond the small crater where the rover landed. In the distance, the rim of a larger crater dubbed 'Endurance' can be seen.

    This color mosaic was taken on the 32nd martian day, or sol, of the rover's mission and spans 20 degrees of the horizon. It was taken while Opportunity was parked at the north end of the outcrop, in front of the rock region dubbed 'El Capitan' and facing east.

    The features seen at the horizon are the near and far rims of 'Endurance,' the largest crater within about 6 kilometers (4 miles) of the lander. Using orbital data from the Mars Orbiter Camera on NASA's Mars Global Surveyor spacecraft, scientists estimated the crater to be 160 meters (175 yards) in diameter, and about 720 meters (half a mile) away from the lander.

    The highest point visible on 'Endurance' is the highest point on the far wall of the crater; the sun is illuminating the inside of the far wall.

    Between the location where the image was taken at 'El Capitan' and 'Endurance' are the flat, smooth Meridiani plains, which scientists believe are blanketed in the iron-bearing mineral called hematite. The dark horizontal feature near the bottom of the picture is a small, five-meter (16-feet) crater, only 50 meters (164 feet) from Opportunity's present position. When the rover leaves the crater some 2 to 3 weeks from now, 'Endurance' is one of several potential destinations.

  8. Horizons of semiclassical black holes are cold

    NASA Astrophysics Data System (ADS)

    Brustein, Ram; Medved, A. J. M.

    2014-06-01

    We calculate, using our recently proposed semiclassical framework, the quantum state of the Hawking pairs that are produced during the evaporation of a black hole (BH). Our framework adheres to the standard rules of quantum mechanics and incorporates the quantum fluctuations of the collapsing shell spacetime in Hawking's original calculation, while accounting for back-reaction effects. We argue that the negative-energy Hawking modes need to be regularly integrated out; and so these are effectively subsumed by the BH and, as a result, the number of coherent negative-energy modes N coh at any given time is parametrically smaller than the total number of the Hawking particles N total emitted during the lifetime of the BH. We find that N coh is determined by the width of the BH wavefunction and scales as the square root of the BH entropy. We also find that the coherent negative-energy modes are strongly entangled with their positive-energy partners. Previously, we have found that N coh is also the number of coherent outgoing particles and that information can be continually transferred to the outgoing radiation at a rate set by N coh . Our current results show that, while the BH is semiclassical, information can be released without jeopardizing the nearly maximal inside-out entanglement and imply that the state of matter near the horizon is approximately the vacuum. The BH firewall proposal, on the other hand, is that the state of matter near the horizon deviates substantially from the vacuum, starting at the Page time. We find that, under the usual assumptions for justifying the formation of a firewall, one does indeed form at the Page time. However, the possible loophole lies in the implicit assumption that the number of strongly entangled pairs can be of the same order of N total .

  9. THERMAL CONDUCTIVITY OF THE POTENTIAL REPOSITORY HORIZON

    SciTech Connect

    J.E. BEAN

    2004-09-27

    The primary purpose of this report is to assess the spatial variability and uncertainty of bulk thermal conductivity in the host horizon for the repository at Yucca Mountain. More specifically, the lithostratigraphic units studied are located within the Topopah Spring Tuff (Tpt) and consist of the upper lithophysal zone (Tptpul), the middle nonlithophysal zone (Tptpmn), the lower lithophysal zone (Tptpll), and the lower nonlithophysal zone (Tptpln). Design plans indicate that approximately 81 percent of the repository will be excavated in the Tptpll, approximately 12 percent in the Tptpmn, and the remainder in the Tptul and Tptpln (BSC 2004 [DIRS 168370]). This report provides three-dimensional geostatistical estimates of the bulk thermal conductivity for the four stratigraphic layers of the repository horizon. The three-dimensional geostatistical estimates of matrix and lithophysal porosity, dry bulk density, and matrix thermal conductivity are also provided. This report provides input to various models and calculations that simulate heat transport through the rock mass. These models include the ''Drift Degradation Analysis, Multiscale Thermohydrologic Model, Ventilation Model and Analysis Report, Igneous Intrusion Impacts on Waste Packages and Waste Forms, Drift-Scale Coupled Processes (DST and TH Seepage) Models'', and ''Drift Scale THM Model''. These models directly or indirectly provide input to the total system performance assessment (TSPA). The main distinguishing characteristic among the lithophysal and nonlithophysal units is the percentage of large-scale (centimeters-meters) voids within the rock. The Tptpul and Tptpll, as their names suggest, have a higher percentage of lithophysae than the Tptpmn and the Tptpln. Understanding the influence of the lithophysae is of great importance to understanding bulk thermal conductivity.

  10. Q & A with Ed Tech Leaders: Interview with J. Michael Spector

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2015-01-01

    J. Michael Spector's academic preparation was in philosophy--epistemology and logic, primarily. His dissertation was on skepticism in modern philosophy, and that led him to a deep-seated appreciation for classical skepticism. The word "skeptic" is derived from the Greek word "skepsis," which means investigation. While the…

  11. Organocatalytic Michael addition/intramolecular Julia-Kocienski olefination for the preparation of nitrocyclohexenes.

    PubMed

    Rodrigo, Eduardo; García Ruano, José Luis; Cid, M Belén

    2013-11-01

    An asymmetric organocatalytic [3 + 3] annulation strategy based on a Michael addition/intramolecular Julia-Kocienski olefination sequence has been developed for the synthesis of 4-substituted-5-nitrocyclohex-1-ene compounds. The strategy is an alternative to the direct reluctant enantioselective Diels-Alder approach. The potential of the methodology has been demonstrated with a concise enantioselective formal synthesis of trandolapril.

  12. Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

    PubMed Central

    2015-01-01

    Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of acrylonitrile-based Michael acceptors, activated by aryl or heteroaryl electron-withdrawing groups. We demonstrate that thiol adducts of these acrylonitriles undergo β-elimination at rates that span more than 3 orders of magnitude. These rates correlate inversely with the computed proton affinity of the corresponding carbanions, enabling the intrinsic reversibility of the thiol-Michael reaction to be tuned in a predictable manner. We apply these principles to the design of new reversible covalent kinase inhibitors with improved properties. A cocrystal structure of one such inhibitor reveals specific noncovalent interactions between the 1,2,4-triazole activating group and the kinase. Our experimental and computational study enables the design of new Michael acceptors, expanding the palette of reversible, cysteine-targeted electrophiles. PMID:25153195

  13. The Journey Is the Film Is the Journey: Michael Winterbottom's "In This World"

    ERIC Educational Resources Information Center

    Farrier, David

    2008-01-01

    This essay examines Michael Winterbottom's 2002 film "In This World," which follows the journey of two Afghan migrants from Peshawar to London. Winterbottom's preparation involved travelling from London to Peshawar and then in reverse overland as far as Istanbul; he then returned to Peshawar and filmed the same journey using two non-professional…

  14. Vision and Elusiveness in Philosophy of Education: R. S. Peters on the Legacy of Michael Oakeshott

    ERIC Educational Resources Information Center

    Williams, Kevin

    2009-01-01

    Despite his elusiveness on important issues, there is much in Michael Oakeshott's educational vision that Richard Peters quite rightly wishes to endorse. The main aim of this essay is, however, to consider Peters' justifiable critique of three features of Oakeshott's work. These are (1) the rigidity of his distinction between vocational and…

  15. Neuroscientific Investigator of High Mathematical Ability: An Interview with Michael W. O'Boyle

    ERIC Educational Resources Information Center

    Kalbfleisch, M. Layne

    2008-01-01

    This article presents an interview with Michael W. O'Boyle, a neuroscientific investigator of high mathematical ability. O'Boyle is a professor in the Department of Human Development and Family Studies, Texas Tech University, and Adjunct Professor of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center.…

  16. A tribute to Michael R. Raupach for contributions to aeolian fluid dynamics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since the early work of Bagnold in the 1940s, aeolian research has grown to become a major integral part of earth-system studies. Many individuals have contributed to this development, and Dr. Michael R. Raupach (MR2, 1950 – 2015) was one of the most outstanding. MR2 worked for about a decade (1985 ...

  17. Michael Pressley's Contributions to the History and Future of Strategies Research

    ERIC Educational Resources Information Center

    Harris, Karen R.; Alexander, Patricia; Graham, Steve

    2008-01-01

    The history of strategies research during the past quarter century has been a story of significant conceptualizations and reconceptualizations regarding the nature, development, and teaching of cognitive and metacognitive strategies. Theoretical models, empirical research, and discussions contributed by Michael Pressley have been central to…

  18. An Interview with Michael Horn: Blending Education for High-Octane Motivation

    ERIC Educational Resources Information Center

    Patterson, Gregory A.

    2012-01-01

    Blended learning holds the potential of improving the way we educate students and of making them more motivated. Blended education--the melding of information technology based distance learning with school attendance--is perhaps the best way to educate students for 21st century skills, says Michael Horn in a "Kappan" interview. Horn points out…

  19. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    PubMed

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age. PMID:10177868

  20. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    PubMed

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age.

  1. What Work Do the Concepts of "Language" and "Literature" Do for Michael Rosenak?

    ERIC Educational Resources Information Center

    Levisohn, Jon A.

    2014-01-01

    Michael Rosenak uses the twin metaphors of "language" and "literature," borrowed from Oakeshott and Peters, to argue that the goal of education is initiation into a language. This goal transcends the study of literature in that language. It includes, as well, the development of the capacity both to critique literature and to…

  2. Michael Eric Dyson: A Scholar and a Hip-Hop Preacher.

    ERIC Educational Resources Information Center

    Fletcher, Michael A.

    2000-01-01

    Introduces Michael Eric Dyson, an African American man who grew up in the ghetto and eventually received a PhD from Princeton University. Today, he is a professor at DePaul University, the author of a radically revisionist new biography of Martin Luther King, Jr., a lecturer and talk show guest, a Baptist preacher, and a self-styled hip-hop…

  3. Michael Peters' Lyotardian Account of Postmodernism and Education: Some Epistemic Problems and Naturalistic Solutions

    ERIC Educational Resources Information Center

    Clark, John A.

    2006-01-01

    Postmodernism has established a significant hold in educational thought and some of the most important ideas are to be found in the writings of Michael Peters. This paper examines his postmodern stance and use of Lyotard's account of knowledge, and from a naturalist point of view raises a number of objections centred on science as a metanarrative,…

  4. Little Mosie from the Margaree: A Biography of Moses Michael Coady.

    ERIC Educational Resources Information Center

    Welton, Michael R.

    This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

  5. From Gouldner to Gramsci: The Making of Michael Apple's "Ideology and Curriculum"

    ERIC Educational Resources Information Center

    Gottesman, Isaac

    2012-01-01

    Michael Apple's "Ideology and Curriculum", published in 1979, helped initiate a broad turn in the field of education in the United States to Marxist thought as a lens through which to analyze the relationship between school and society. This classic text continues to inform scholarship in the field. While "Ideology" has received considerable…

  6. 76 FR 21406 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... Decision of the Administrative Law Judge (76 FR 19420). In preparing the document for publication, the... at 76 FR 19420 under the third column. Dated: April 8, 2011. Michele M. Leonhart, Administrator... Enforcement Administration Michael J. Aruta, M.D.; Decision and Order ACTION: Correction. On Thursday, April...

  7. Asymmetric Michael addition reactions of nitroalkanes to 2-furanones catalyzed by bifunctional thiourea catalysts.

    PubMed

    Bai, Zhushuang; Ji, Ling; Ge, Zemei; Wang, Xin; Li, Runtao

    2015-05-21

    The first bifunctional thiourea catalyzed asymmetric Michael addition reactions of nitroalkanes to 2-furanones are described. The highly functionalized γ-lactones with two or three consecutive stereogenic carbons were obtained in high yields (up to 99%), high diastereoselectivities (up to >20 : 1 dr) and enantioselectivities (up to >99% ee).

  8. On Not Abolishing Faith Schools: A Response to Michael Hand and H. Siegel

    ERIC Educational Resources Information Center

    Groothuis, Douglas

    2004-01-01

    This article finds Michael's Hand's argument for the abolition of faith schools to be deficient because key premises of his argument seem false. I argue that the concept of knowledge that Hand employs in arguing that no religious proposition is known to be true is overly strict. I reject Siegel's attempt to amend Hand's argument to make it…

  9. Training and Mastery of Techniques in Wittgenstein's Later Philosophy: A Response to Michael Luntley

    ERIC Educational Resources Information Center

    Stickney, Jeff

    2008-01-01

    Responding to Michael Luntley's article, "Learning, Empowerment and Judgement," the author shows he cannot successfully make the following three moves: (1) dissolve the analytic distinction between learning by training and learning by reasoning, while advocating the latter; (2) diminish the role of training in Wittgenstein's philosophy, nor…

  10. Irish Education for the 21st Century. Michael Enright Commemorative Project.

    ERIC Educational Resources Information Center

    Ward, Noel, Ed.; Dooney, Triona, Ed.

    The essays in this collection contribute to the ongoing discussion about the state of Irish education on the threshold of a new century. The various contributors examine issues that will be priorities for education planners in Ireland. These essays have been collected as a tribute to Irish educator and politician Michael Enright. The essays are:…

  11. Broadening the Debate: Comments on Michael J. Feuer's "Moderating the Debate"

    ERIC Educational Resources Information Center

    Robertson, Emily

    2009-01-01

    In "Moderating the Debate: Rationality and the Promise of American Education", Michael Feuer argues that insights from cognitive science and the theory of bounded rationality can help us understand why educational policy makers overreach in seeking optimal solutions to educational problems. In this essay, Emily Robertson argues that cognitive…

  12. C. P. Snow's "The Two Cultures": Michael Polanyi's Response and Context

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2011-01-01

    C. P. Snow's "The Two Cultures" controversially contrasted science and literature, suggesting that neither scientists nor literary intellectuals have much in common with, and seldom bother speaking to, the other. Responding to Snow, Michael Polanyi argued that specialization has made modern culture, not twofold but manifold. In his major work,…

  13. Michael E. Barnes: Award for Distinguished Professional Contributions to Institutional Practice

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents a short biography on the winner of the American Psychological Association's Award for Distinguished Professional Contributions to Institutional Practice. The 2012 winner is Michael E. Barnes for his pioneering leadership, dedication, and distinguished contributions to juvenile justice. As chief psychologist of the Superior Court of the…

  14. A Response to Michael W. Apple's "Theory, Research, and the Critical Scholar/Activist"

    ERIC Educational Resources Information Center

    Leonardo, Zeus

    2010-01-01

    Michael Apple's prescient review of Anyon et al.'s "Theory and Educational Research" reminds the educational community of the importance of purpose. In his own work, he has been consistent in--actually, insistent on--emphasizing the struggle over political projects. This is not an issue concerning only the Left as the scapegoat for the disparaging…

  15. Learning to Lose: Rurality, Transience, and Belonging (A Companion to Michael Corbett)

    ERIC Educational Resources Information Center

    Kelly, Ursula A.

    2009-01-01

    In this commentary, the author focuses on the central point of Michael Corbett's book "Learning to Leave". Education, and in particular what is called "rural" education, is premised on loss. This loss is often not fully articulated, but it is deep and abiding. It is registered in efforts to stop the flow of people and resources, to resist…

  16. The Benevolent Technocrat: Michael Dukakis' Strategy in the 1988 Presidential Debates.

    ERIC Educational Resources Information Center

    Herbeck, Dale A.

    Michael Dukakis lost the presidential campaign debates of 1988 (or at least failed to capitalize as much as he might have) because he understood the debates to be genuine debates. Consequently, Dukakis acted as a debater generating an image of himself as a "benevolent technocrat," which was an error. It must be pointed out that the presidential…

  17. Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

    NASA Astrophysics Data System (ADS)

    Brendel, Michelle

    2014-12-01

    Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

  18. Why Do We Need a Philosophy of Education? The Forgotten Insights of Michael John Demiashkevich

    ERIC Educational Resources Information Center

    Senechal, Diana

    2010-01-01

    For many decades, American schools have been mired in jargon and confused values. A few exceptional books have shown the way through the thicket of educational ideas, policies, and practices. The work of Michael John Demiashkevich belongs to this set and offers a special philosophical perspective. In "An Introduction to the Philosophy of…

  19. Michael Shaffer, 6th July 1936 to 23rd March 2009: A heartfelt tribute

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mr. Michael Shaffer, Retired Pyraloidea Curator, at the Natural History Museum, London, England, passed away on March 23, 2009. He was an acknowledged world expert on Pyraloidea, a group of agriculturally important moths. He was curator of the largest Pyraloidea type collection in the world, and a...

  20. Q & A with Ed Tech Leaders: Interview with Michael W. Allen

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.

    2014-01-01

    Michael W. Allen, the Chairman and CEO of Allen Interactions, is an architect of interactive multimedia learning and is recognized for his many insights, inventions, and presentations. With over 50 years of experience in e-learning, both in academic and corporate settings, he is known for his role in creating Authorware and overseeing the work of…

  1. Moral Education and Education in Altruism: Two Replies to Michael Hand

    ERIC Educational Resources Information Center

    White, John

    2016-01-01

    This article is a critical discussion of two recent papers by Michael Hand on moral education. The first is his "Towards a Theory of Moral Education", published in the "Journal of Philosophy of Education" in 2014 (Volume 48, Issue 4). The second is a chapter called "Beyond Moral Education?" in an edited book of new…

  2. "Raising Standards" or Reducing Aspirations and Opportunities Still Further? Michael Gove and Examination Reforms

    ERIC Educational Resources Information Center

    Allen, Martin

    2013-01-01

    Well before the examinations grade crisis of 2012, Michael Gove had set out clear intentions for reforming public examinations. Though he claimed to be improving examinations and assessment by replicating practices that took place in high-performing countries and thus improving the ability of the UK economy to "compete", this…

  3. Education, Philosophy and Politics: The Selected Works of Michael A. Peters. World Library of Educationalists

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2012-01-01

    In the World Library of Educationalists series, international experts themselves compile career-long collections of what they judge to be their finest pieces--extracts from books, key articles, salient research findings, major theoretical and/practical contributions--so the world can read them in a single manageable volume. Michael A. Peters has…

  4. Schools as "Poetry-Friendly Places": Michael Rosen on Poetry in the Curriculum

    ERIC Educational Resources Information Center

    Xerri, Daniel

    2014-01-01

    This article explores the views of children's poet Michael Rosen in relation to poetry in education. It is based on an interview in which Rosen not only discusses the significance of encouraging young people to engage with poetry at school but also analyzes a number of threats to poetry's place in the English curriculum. This article…

  5. STS-34 Pilot Michael J. McCulley uses ARRIFLEX camera equipment

    NASA Technical Reports Server (NTRS)

    1989-01-01

    STS-34 Atlantis, Orbiter Vehicle (OV) 104, Pilot Michael J. McCulley squints while looking through ARRIFLEX camera eye piece during camera briefing at JSC. McCulley rests part of the camera on his shoulder as he operates it.

  6. Astronaut C. Michael Foale is briefed on use of Sky Genie

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Astronaut C. Michael Foale, STS-63 mission specialist, is briefed on the use of Sky Genie device by Karin L. Porter. The device would aid in emergency egress operations aboard a troubled Space Shuttle. Porter, an employee of Rockwell International, helps train astronauts in egress procedures at JSC's Shuttle mockup and integration laboratory.

  7. The Educational Philosophies of Mordecai Kaplan and Michael Rosenak: Surprising Similarities and Illuminating Differences

    ERIC Educational Resources Information Center

    Schein, Jeffrey; Caplan, Eric

    2014-01-01

    The thoughts of Mordecai Kaplan and Michael Rosenak present surprising commonalities as well as illuminating differences. Similarities include the perception that Judaism and Jewish education are in crisis, the belief that Jewish peoplehood must include commitment to meaningful content, the need for teachers to teach from a position of…

  8. Michael Faraday on the Learning of Science and Attitudes of Mind.

    ERIC Educational Resources Information Center

    Crawford, Elspeth

    1998-01-01

    Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

  9. Michael Oakeshott's Philosophy of Education and Its Implications for Instructional Design Theory and Practice.

    ERIC Educational Resources Information Center

    Tripp, Steven

    Michael Oakeshott, an English political philosopher, wrote extensively about education and how people learn political skills. Much of what he wrote may have interesting implications for instructional systems design. This paper is an explication of two aspects of Oakeshott's writings. The first deals with the nature of knowledge and its…

  10. Subjectivity and Cultural Adjustment in Mathematics Education: A Response to Wolff-Michael Roth

    ERIC Educational Resources Information Center

    Brown, Tony

    2012-01-01

    In this volume, Wolff-Michael Roth provides a critical but partial reading of Tony Brown's book "Mathematics Education and Subjectivity". The reading contrasts Brown's approach with Roth's own conception of subjectivity as derived from the work of Vygotsky, in which Roth aims to "reunite" psychology and sociology. Brown's book, however, focuses on…

  11. New Horizons 20 Years On. Occasional Papers Series: No. 7.

    ERIC Educational Resources Information Center

    Gordon, Margaret

    New Horizons is a course offered by the University of Edinburgh's Centre for Continuing Education that is aimed at first-time returners to education. In the 20 years since New Horizons was developed for women returners to education and/or employment, it has retained its original developmental outcomes but broadened its target group in response to…

  12. New Horizons Risk Communication Strategy, Planning, Implementation, and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Dawson, Sandra A.

    2006-01-01

    This paper discusses the risk communication goals, strategy, planning process and product development for the New Horizons mission, including lessons from the Cassini mission that were applied in that effort, and presents lessons learned from the New Horizons effort that could be applicable to future missions.

  13. The NMC Horizon Report: 2015 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The "NMC Horizon Report: 2015 Higher Education Edition" is a collaborative effort between the New Media Consortium (NMC) and the EDUCAUSE Learning Initiative (ELI). This 12th edition describes annual findings from the NMC Horizon Project, an ongoing research project designed to identify and describe emerging technologies likely to have…

  14. The NMC Horizon Report: 2014 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2014-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within every sector of education in some 65…

  15. The NMC Horizon Report: 2012 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams, S.; Cummins, M.

    2012-01-01

    The internationally recognized "NMC Horizon Report" series and regional "NMC Technology Outlooks" are part of the NMC Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years in education around the globe. This volume, the "NMC…

  16. NEW JERSEY APPROACH TO OUTERBRIDGE CROSSING BRIDGE, NOTE DISTANT HORIZON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NEW JERSEY APPROACH TO OUTERBRIDGE CROSSING BRIDGE, NOTE DISTANT HORIZON NEW YORK SKYLINE AND ALMOST IN THE MIDDLE OF THE HORIZON THE TWIN TOWERS OF THE VERRAZANO-NARROWS BRIDGE - Outerbridge Crossing Bridge, Spanning Arthur Kill from New Jersey to Staten Island, Staten Island (subdivision), Richmond County, NY

  17. A Fusion of Horizons: Students' Encounters with "Will and Wave"

    ERIC Educational Resources Information Center

    Myers, James L.

    2006-01-01

    In a case study, I applied philosophical hermeneutic principles in an advanced level EFL writing class in Taiwan. A "fusion of horizons" occurs at the junction of two intertwined interpretations: one from our socio-historical tradition and the other from our experience of novel phenomena. I explored students' hermeneutic horizons in relation to…

  18. The Horizon Report: 2009 Australia-New Zealand Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Smith, R.; Smythe, T.; Stone, S.

    2009-01-01

    The New Media Consortium's Horizon Project is an ongoing research project that aims to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative inquiry within education around the globe over a five-year time period. The project's central products are the "Horizon Reports", an annual series of…

  19. The NMC Horizon Report: 2011 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams, S.; Haywood, K.

    2011-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium. (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This volume, "The…

  20. The NMC Horizon Report: 2013 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Cummins, M.; Estrada V.; Freeman, A.; Ludgate, H.

    2013-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This…

  1. The Horizon Report: 2010 Australia-New Zealand Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Smith, R.; Levine, A.; Haywood, K.

    2010-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years on a variety of sectors around the globe. This volume, the "2010 Horizon…

  2. Observations of the Geometry of Horizon-Based Optical Navigation

    NASA Technical Reports Server (NTRS)

    Christian, John; Robinson, Shane

    2016-01-01

    NASA's Orion Project has sparked a renewed interest in horizon-based optical navigation(OPNAV) techniques for spacecraft in the Earth-Moon system. Some approaches have begun to explore the geometry of horizon-based OPNAV and exploit the fact that it is a conic section problem. Therefore, the present paper focuses more deeply on understanding and leveraging the various geometric interpretations of horizon-based OPNAV. These results provide valuable insight into the fundamental workings of OPNAV solution methods, their convergence properties, and associated estimate covariance. Most importantly, the geometry and transformations uncovered in this paper lead to a simple and non-iterative solution to the generic horizon-based OPNAV problem. This represents a significant theoretical advancement over existing methods. Thus, we find that a clear understanding of geometric relationships is central to the prudent design, use, and operation of horizon-based OPNAV techniques.

  3. Successful treatment of recalcitrant candidal intertrigo with Dr Michaels® (Fungatinex®) product family.

    PubMed

    Hercogovấ, J; Tirant, M; Bayer, P; Coburn, M; Donnelly, B; Kennedy, T; Gaibor, J; Arora, M; Clews, L; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Candidal intertrigo is an infection of the skin caused by Candida albicans that typically occurs in opposing cutaneous or muco-cutaneous surfaces. Because Candidiasis requires a damaged and moist environment for infection, it typically occurs in areas of friction such as the skin folds of the body. Candidal intertrigo is often difficult to treat and results are often unsatisfactory. In addition, there is a lack of evidence-based literature supporting prevention and treatments for candidal intertrigo. The aim of the study was to evaluate the efficacy of Dr Michaels® (also branded as Fungatinex®) products in the treatment of fungal intertrigo, in 20 women and 2 men with a mean age of 72. Five patients (3 female and 2 male) had type 2 diabetes and 16 (14 female and 2 male) were obese. The patients were treated with Dr Michaels® (Fungatinex®) moisturising bar, topical ointment (twice daily application) and oral herbal formulation, PSC 200 two tablets twice daily with food. After 2 weeks of treatment, the lesions had mostly resolved in all patients with only slight erythema evident. After six weeks of treatment using the moisturising bar, topical ointment and oral herbal formulations from the Dr Michaels® (Fungatinex®) product family, the lesions had totally resolved in 18 patients, while 4 patients had to continue the therapeutic protocol for another 2 weeks. Our results demonstrate that the Dr Michaels® (Fungatinex®) complementary product family is efficacious in the treatment of recalcitrant candidal intertrigo. Furthermore, this study highlights that the Dr Michaels® (Fungatinex®) product family is fast-acting and well tolerated with no serious adverse events reported. These data have important implications for resistant cases of candidal intertrigo where traditional therapies have failed. PMID:27498664

  4. A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES WITH GENOMIC, PROTEOMIC AND METABONOMIC COMPONENTS

    EPA Science Inventory

    A Database for Tracking Toxicogenomic Samples and Procedures with Genomic, Proteomic and Metabonomic Components
    Wenjun Bao1, Jennifer Fostel2, Michael D. Waters2, B. Alex Merrick2, Drew Ekman3, Mitchell Kostich4, Judith Schmid1, David Dix1
    Office of Research and Developmen...

  5. 76 FR 55427 - Horizon Technology Finance Corporation, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... COMMISSION Horizon Technology Finance Corporation, et al.; Notice of Application August 31, 2011. AGENCY...(a) of the Act. Applicants: Horizon Technology Finance Corporation (the ``Company''), Horizon Technology Finance Management LLC (the ``Investment Adviser''), Longview SBIC GP LLC (the ``General...

  6. Horizon News Function and Quasi-Local Energy-Momentum Flux Near Black Hole

    NASA Astrophysics Data System (ADS)

    Wu, Yu-Huei

    2008-09-01

    From the 'quasi-local' definition of horizons, e.g. isolated horizon and dynamical horizon, the consequence quasi-local energy-momentum near horizons can be observed by using the idea of frame alignment. In particular, we find the horizon news function from the asymptotic expansion near horizons and use this to describe the gravitational flux and change of mass of a black hole.

  7. Physical process first law for bifurcate Killing horizons

    SciTech Connect

    Amsel, Aaron J.; Marolf, Donald; Virmani, Amitabh

    2008-01-15

    The physical process version of the first law for black holes states that the passage of energy and angular momentum through the horizon results in a change in area ({kappa}/8{pi}){delta}A={delta}E-{omega}{delta}J, so long as this passage is quasistationary. A similar physical process first law can be derived for any bifurcate Killing horizon in any spacetime dimension d{>=}3 using much the same argument. However, to make this law nontrivial, one must show that sufficiently quasistationary processes do in fact occur. In particular, one must show that processes exist for which the shear and expansion remain small, and in which no new generators are added to the horizon. Thorne, MacDonald, and Price considered related issues when an object falls across a d=4 black hole horizon. By generalizing their argument to arbitrary d{>=}3 and to any bifurcate Killing horizon, we derive a condition under which these effects are controlled and the first law applies. In particular, by providing a nontrivial first law for Rindler horizons, our work completes the parallel between the mechanics of such horizons and those of black holes for d{>=}3. We also comment on the situation for d=2.

  8. Spacetimes foliated by nonexpanding and Killing horizons: Higher dimension

    NASA Astrophysics Data System (ADS)

    Lewandowski, Jerzy; Szereszewski, Adam; Waluk, Piotr

    2016-09-01

    The theory of nonexpanding horizons (NEHs) geometry and the theory of near-horizon geometries (NHGs) are two mathematical relativity frameworks generalizing the black hole theory. From the point of view of the NEHs theory, a NHG is just a very special case of a spacetime containing a NEH of many extra symmetries. It can be obtained as the Horowitz limit of a neighborhood of an arbitrary extremal Killing horizon. An unexpected relation between the two of them was discovered in the study of spacetimes foliated by a family of NEHs. The class of four-dimensional NHG solutions (either vacuum or coupled to a Maxwell field) was found as a family of examples of spacetimes admitting a NEH foliation. In the current paper, we systematically investigate geometries of the NEHs foliating a spacetime for arbitrary matter content and in arbitrary spacetime dimensions. We find that each horizon belonging to the foliation satisfies a condition that may be interpreted as an invitation for a transversal NEH to exist and to admit the structure of an extremal isolated horizon. Assuming the existence of a transversal extremal isolated horizon, we derive all the spacetime metrics satisfying the vacuum Einstein's equations. In this case, the NEHs become bifurcated Killing horizons.

  9. Horizon shells and BMS-like soldering transformations

    NASA Astrophysics Data System (ADS)

    Blau, Matthias; O'Loughlin, Martin

    2016-03-01

    We revisit the theory of null shells in general relativity, with a particular emphasis on null shells placed at horizons of black holes. We study in detail the considerable freedom that is available in the case that one solders two metrics together across null hypersurfaces (such as Killing horizons) for which the induced metric is invariant under translations along the null generators. In this case the group of soldering transformations turns out to be infinite dimensional, and these solderings create non-trivial horizon shells containing both massless matter and impulsive gravitational wave components. We also rephrase this result in the language of Carrollian symmetry groups. To illustrate this phenomenon we discuss in detail the example of shells on the horizon of the Schwarzschild black hole (with equal interior and exterior mass), uncovering a rich classical structure at the horizon and deriving an explicit expression for the general horizon shell energy-momentum tensor. In the special case of BMS-like soldering supertranslations we find a conserved shell-energy that is strikingly similar to the standard expression for asymptotic BMS supertranslation charges, suggesting a direct relation between the physical properties of these horizon shells and the recently proposed BMS supertranslation hair of a black hole.

  10. Large Dust Devil on Horizon, Sol 468

    NASA Technical Reports Server (NTRS)

    2005-01-01

    This movie clip shows a large, distant dust devil -- a whirlwind that lofts dust into the air -- as a dark shape on the horizon near the right side of the images. This dust devil was about 5 kilometers (3 miles) away from NASA's Mars Exploration Rover Spirit, and may have been up to 200 meters or yards in diameter. Smaller dust devils closer to the rover appear bright against the dark ground. Spirit's navigation camera took these images on the rover's 468th martian day, or sol (April 27, 2005.) Contrast has been enhanced for anything in the images that changes from frame to frame, that is, for the dust devil. The number of seconds elapsed since the first frame is indicated at lower left of the images, typically 20 seconds between frames.

    Scientists expected dust devils since before Spirit landed. The landing area inside Gusev Crater is filled with dark streaks left behind when dust devils pick dust up from an area. It is also filled with bright 'hollows,' which are dust-filled miniature craters. Dust covers most of the terrain. Winds flow into and out of Gusev crater every day. The Sun heats the surface so that the surface is warm to the touch even though the atmosphere at 2 meters (6 feet) above the surface would be chilly. That temperature contrast causes convection. Mixing the dust, winds, and convection can trigger dust devils.

  11. Possible New Horizons Fundamental Contribution to Cosmology

    NASA Astrophysics Data System (ADS)

    Conn Henry, Richard; Murthy, Jayant

    2016-01-01

    The New Horizons (NH) spacecraft (S. Alan Stern, PI) is now past Pluto, and in our poster we explore the possibility of making observations, using the NH P-Alice ultraviolet spectrometer, of the cosmic diffuse ultraviolet background radiation, particularily at high northern and southern Galactic latitudes. In the paper, "The Mystery of the Cosmic Diffuse Ultraviolet Background Radiation," by Richard Conn Henry, Jayant Murthy, James Overduin, Joshua Tyler, ApJ, 798:14 (25pp), 2015 January 1, we demonstrated the existence of a second component of the diffuse far ultraviolet background radiation beyond that provided by dust-scattered starlight. The critical question is, does that second component (of unknown origin) extend shortward of the Lyman limit of 912 Å? If it does, then it seems likely that we have discovered the source of the reionization of the Universe that occurred some time after recombination. As things stand at the moment, there is no known source that has been demonstrated to be capable of performing the reionization: reionization that clearly did occur. Our current understanding of P-Alice suggests that it may well be capable of demonstrating the presence (or absence) of such ionizing cosmic diffuse radiation. At low Galactic latitudes, all such radiation would be totally erased by the presence, in large quantities, of interstellar neutral hydrogen; this will allow us to test the reality of any such flux that we may discover at higher Galactic latitudes.

  12. New geometries for black hole horizons

    NASA Astrophysics Data System (ADS)

    Armas, Jay; Blau, Matthias

    2015-07-01

    We construct several classes of worldvolume effective actions for black holes by integrating out spatial sections of the worldvolume geometry of asymptotically flat black branes. This provides a generalisation of the blackfold approach for higher-dimensional black holes and yields a map between different effective theories, which we exploit by obtaining new hydrodynamic and elastic transport coefficients via simple integrations. Using Euclidean minimal surfaces in order to decouple the fluid dynamics on different sections of the worldvolume, we obtain local effective theories for ultraspinning Myers-Perry branes and helicoidal black branes, described in terms of a stress-energy tensor, particle currents and non-trivial boost vectors. We then study in detail and present novel compact and non-compact geometries for black hole horizons in higher-dimensional asymptotically flat space-time. These include doubly-spinning black rings, black helicoids and helicoidal p-branes as well as helicoidal black rings and helicoidal black tori in D ≥ 6.

  13. LANDSAT-4 horizon scanner performance evaluation

    NASA Technical Reports Server (NTRS)

    Bilanow, S.; Chen, L. C.; Davis, W. M.; Stanley, J. P.

    1984-01-01

    Representative data spans covering a little more than a year since the LANDSAT-4 launch were analyzed to evaluate the flight performance of the satellite's horizon scanner. High frequency noise was filtered out by 128-point averaging. The effects of Earth oblateness and spacecraft altitude variations are modeled, and residual systematic errors are analyzed. A model for the predicted radiance effects is compared with the flight data and deficiencies in the radiance effects modeling are noted. Correction coefficients are provided for a finite Fourier series representation of the systematic errors in the data. Analysis of the seasonal dependence of the coefficients indicates the effects of some early mission problems with the reference attitudes which were computed by the onboard computer using star trackers and gyro data. The effects of sun and moon interference, unexplained anomalies in the data, and sensor noise characteristics and their power spectrum are described. The variability of full orbit data averages is shown. Plots of the sensor data for all the available data spans are included.

  14. Entanglement, tensor networks and black hole horizons

    NASA Astrophysics Data System (ADS)

    Molina-Vilaplana, J.; Prior, J.

    2014-11-01

    We elaborate on a previous proposal by Hartman and Maldacena on a tensor network which accounts for the scaling of the entanglement entropy in a system at a finite temperature. In this construction, the ordinary entanglement renormalization flow given by the class of tensor networks known as the Multi Scale Entanglement Renormalization Ansatz (MERA), is supplemented by an additional entanglement structure at the length scale fixed by the temperature. The network comprises two copies of a MERA circuit with a fixed number of layers and a pure matrix product state which joins both copies by entangling the infrared degrees of freedom of both MERA networks. The entanglement distribution within this bridge state defines reduced density operators on both sides which cause analogous effects to the presence of a black hole horizon when computing the entanglement entropy at finite temperature in the AdS/CFT correspondence. The entanglement and correlations during the thermalization process of a system after a quantum quench are also analyzed. To this end, a full tensor network representation of the action of local unitary operations on the bridge state is proposed. This amounts to a tensor network which grows in size by adding succesive layers of bridge states. Finally, we discuss on the holographic interpretation of the tensor network through a notion of distance within the network which emerges from its entanglement distribution.

  15. New Horizons Investigation of Pluto's Small Satellites

    NASA Astrophysics Data System (ADS)

    Weaver, H. A., Jr.

    2015-12-01

    Pluto has four small moons: Styx, Nix, Kerberos, and Hydra, in orderof their distance from Pluto. All were discovered using theHubble Space Telescope (HST): Nix and Hydra in 2005 (1), Kerberos in2011 (2), and Styx in 2012 (3). The New Horizons (NH) mission has provided the first opportunity toperform spatially resolved imaging and spectroscopic measurements ofPluto's small moons, thereby giving direct measurements of theirsizes, shapes, surface albedo and color variations, surface composition,and snapshots of their rotational states. In addition, an extensive andsystematic set of unresolved panchromatic brightness measurements of thesmall moons over a six month period (January-July 2015) was obtained byNH, which provides additional information on their shapes and more preciseinformation on their rotational states. Here we review the results obtained to date by NH on the propertiesof Pluto's small moons. We compare those results to the propertiesof other small bodies in the solar system, and we address how thenew NH results bear on the origin and evolution of the Pluto system. (1) H. A. Weaver et al., Discovery of two new satellites of Pluto Nature 439, 943 (2006).(2) M. R. Showalter et al., New satellite of (134340) Pluto: S/2011 (134340), IAU Circ. 9221 (2011).(3) M. R. Showalter et al., New satellite of (134340) Pluto: S/2011 (134340), IAU Circ. 9253 (2012).

  16. Area Theorem and Smoothness of Compact Cauchy Horizons

    NASA Astrophysics Data System (ADS)

    Minguzzi, E.

    2015-10-01

    We obtain an improved version of the area theorem for not necessarily differentiable horizons which, in conjunction with a recent result on the completeness of generators, allows us to prove that under the null energy condition every compactly generated Cauchy horizon is smooth and compact. We explore the consequences of this result for time machines, topology change, black holes and cosmic censorship. For instance, it is shown that compact Cauchy horizons cannot form in a non-empty spacetime which satisfies the stable dominant energy condition wherever there is some source content.

  17. Horizon scan of global conservation issues for 2011.

    PubMed

    Sutherland, William J; Bardsley, Sarah; Bennun, Leon; Clout, Mick; Côté, Isabelle M; Depledge, Michael H; Dicks, Lynn V; Dobson, Andrew P; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Impey, Andrew J; Lawton, John H; Lickorish, Fiona; Lindenmayer, David B; Lovejoy, Thomas E; Nally, Ralph Mac; Madgwick, Jane; Peck, Lloyd S; Pretty, Jules; Prior, Stephanie V; Redford, Kent H; Scharlemann, Jörn P W; Spalding, Mark; Watkinson, Andrew R

    2011-01-01

    This review describes outcomes of a 2010 horizon-scanning exercise building upon the first exercise conducted in 2009. The aim of both horizon scans was to identify emerging issues that could have substantial impacts on the conservation of biological diversity, and to do so sufficiently early to encourage policy-relevant, practical research on those issues. Our group included professional horizon scanners and researchers affiliated with universities and non- and inter-governmental organizations, including specialists on topics such as invasive species, wildlife diseases and coral reefs. We identified 15 nascent issues, including new greenhouse gases, genetic techniques to eradicate mosquitoes, milk consumption in Asia and societal pessimism. PMID:21126797

  18. Quantum correlations through event horizons: Fermionic versus bosonic entanglement

    SciTech Connect

    Martin-Martinez, Eduardo; Leon, Juan

    2010-03-15

    We disclose the behavior of quantum and classical correlations among all the different spatial-temporal regions of a space-time with an event horizon, comparing fermionic with bosonic fields. We show the emergence of conservation laws for entanglement and classical correlations, pointing out the crucial role that statistics plays in the information exchange (and more specifically, the entanglement tradeoff) across horizons. The results obtained here could shed new light on the problem of information behavior in noninertial frames and in the presence of horizons, giving better insight into the black-hole information paradox.

  19. Highly Enantioselective Aza-Michael Reaction between Alkyl Amines and β-Trifluoromethyl β-Aryl Nitroolefins.

    PubMed

    Wang, Leming; Chen, Jiean; Huang, Yong

    2015-12-14

    The aza-Michael addition reaction is a vital transformation for the synthesis of functionalized chiral amines. Despite intensive research, enantioselective aza-Michael reactions with alkyl amines as the nitrogen donor have not been successful. We report the use of chiral N-heterocyclic carbenes (NHCs) as noncovalent organocatalysts to promote a highly selective aza-Michael reaction between primary alkyl amines and β-trifluoromethyl β-aryl nitroolefins. In contrast to classical conjugate-addition reactions, a strategy of HOMO-raising activation was used. Chiral trifluoromethylated amines were synthesized in high yield (up to 99 %) with excellent enantioselectivity (up to 98 % ee).

  20. Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    PubMed

    2011-11-01

    Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  1. Sir Michael Francis Addison Woodruff (1911-2001) FRS DSc MD MS FRCS.

    PubMed

    Leigh, Winston

    2011-02-01

    Michael Woodruff performed the first successful renal transplant in the UK and described the technique of joining the ureter of the transplant to the bladder. He contributed to all aspects of transplantation biology and was responsible for the design of the first purpose-built transplant unit in the world. As a Japanese prisoner of war at Changi in Singapore, Michael Woodruff studied the effects of malnutrition and devised a machine for extracting vitamins and trace elements from grass. After the war he demonstrated that the anterior chamber of the eye was an immunologically privileged site. He was the first person to describe 'adaptation'. He showed that antilymphocytic serum was effective as an immunosuppressive agent for homografts.

  2. Synthesis of dithiafulvene-quinone donor-acceptor systems: isolation of a Michael adduct.

    PubMed

    Lissau, Henriette; Jevric, Martyn; Madsen, Anders Østergaard; Nielsen, Mogens Brøndsted

    2015-06-01

    π-Conjugated donor-acceptor systems based on dithiafulvene (DTF) donor units and various acceptor units have attracted attention for their linear and nonlinear optical properties. The reaction between p-benzoquinone and a 1,3-dithiole phosphonium salt, deprotonated by lithium hexamethyldisilazide (LiHMDS), gave a product mixture from which the Michael adduct [systematic name: dimethyl 2-(3-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)-2H-1,3-dithiole-4,5-dicarboxylate], C13H10O6S2, was isolated. It is likely that one of the unidentified products obtained previously by others from related reactions could be a similar Michael adduct.

  3. Accessing N-Stereogenicity through a Double Aza-Michael Reaction: Mechanistic Insights.

    PubMed

    Kohrt, Sonja; Santschi, Nico; Cvengroš, Ján

    2016-01-01

    Further development of the chemistry and applications of chiral compounds that possess configurationally stable stereogenic nitrogen atoms is hampered by the lack of efficient strategies to access such compounds in an enantiomerically pure form. Esters of propiolic acid and chiral alcohols were evaluated as cheap and readily available Michael acceptors in a diastereoselective synthesis of N-stereogenic compounds by means of a double aza-Michael conjugate addition. Diastereomeric ratios of up to 74:26 and high yields were achieved with (-)-menthyl propiolate as a substrate. Furthermore, a detailed mechanistic investigation was undertaken to shed some light on the course of this domino transformation. Kinetic studies revealed that the protic-solvent additive acts as a Brønsted acid and activates the ester toward the initial attack of the tetrahydrodiazocine partner. Conversely, acidic conditions proved unfavorable during the final cyclization step that provides the product.

  4. Highlighting High Performance: Michael E. Capuano Early Childhood Center; Somerville, Massachusetts

    SciTech Connect

    Not Available

    2006-03-01

    This brochure describes the key high-performance building features of the Michael E. Capuano Early Childhood Center. The brochure was paid for by the Massachusetts Technology Collaborative as part of their Green Schools Initiative. High-performance features described are daylighting and energy-efficient lighting, indoor air quality, solar and wind energy, building envelope, heating and cooling systems, water conservation, and acoustics. Energy cost savings are also discussed.

  5. Deracemizing organocatalyzed Michael addition reactions of 2-(arylthio)cyclobutanones with β-nitrostyrenes.

    PubMed

    Luridiana, Alberto; Frongia, Angelo; Aitken, David J; Guillot, Regis; Sarais, Giorgia; Secci, Francesco

    2016-04-01

    Organocatalyzed Michael addition reactions of 2-(arylthio)cyclobutanones with trans-β-nitrostyrenes have been carried out using a bifunctional thiourea-primary amine catalyst, providing diastereoisomerically and enantiomerically enriched 2-alkyl-2-(arylthio)cyclobutanones having two contiguous stereocenters of which one is a chiral quaternary center. The absolute configuration of these novel adducts was assigned by X-ray diffraction analysis and a transition-state model is proposed to explain the observed stereoselectivities.

  6. Thiourea catalyzed organocatalytic enantioselective Michael addition of diphenyl phosphite to nitroalkenes.

    PubMed

    Alcaine, Ana; Marqués-López, Eugenia; Merino, Pedro; Tejero, Tomás; Herrera, Raquel P

    2011-04-21

    Bifunctional thiourea catalyzes the enantioselective Michael addition reaction of diphenyl phosphite to nitroalkenes. This methodology provides a facile access to enantiomerically enriched β-nitrophosphonates, precursors for the preparation of synthetically and biologically useful β-aminophosphonic acids. DFT level of computational calculations invoke the attack of the diphenyl phosphite to the nitroolefin by the Re face, this give light to this scarcely explored process update in the literature. The computational calculations support the absolute configuration obtained in the final adducts.

  7. Stereodivergent Organocatalytic Intramolecular Michael Addition/Lactonization for the Asymmetric Synthesis of Substituted Dihydrobenzofurans and Tetrahydrofurans

    PubMed Central

    Belmessieri, Dorine; de la Houpliere, Alix; Calder, Ewen D D; Taylor, James E; Smith, Andrew D

    2014-01-01

    A stereodivergent asymmetric Lewis base catalyzed Michael addition/lactonization of enone acids into substituted dihydrobenzofuran and tetrahydrofuran derivatives is reported. Commercially available (S)-(−)-tetramisole hydrochloride gives products with high syn diastereoselectivity in excellent enantioselectivity (up to 99:1 d.r.syn/anti, 99 % eesyn), whereas using a cinchona alkaloid derived catalyst gives the corresponding anti-diastereoisomers as the major product (up to 10:90 d.r.syn/anti, 99 % eeanti). PMID:24989672

  8. STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Truss

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Integrated Truss Structure, the primary payload for the mission. The P1 truss will be attached to the central truss segment, S0 Truss, during spacewalks. The payload also includes the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. STS-113 is scheduled to launch Oct. 6, 2002.

  9. STS-69 MS Michael L. Gernhardt greets his mother at SLF

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-69 Mission Specialist Michael L. Gernhardt (right) gets a chance to say hi to his mother, Suzanne Winters, and her husband Doug, after the STS-69 flight crew arrived at KSC's Shuttle Landing Facility. The five astronauts assigned to the mission are looking forward to a liftoff aboard the Space Shuttle Endeavour during a two and a half hour window opening at 11:09 a.m. EDT, Sept. 7.

  10. Group 12, 1987 ASCAN C. Michael Foale sits at the pilots station in JSC's FFT

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Group 12, 1987 Astronaut Candidate (ASCAN) C. Michael Foale sits at the forward flight deck pilots station controls in JSC's Full Fuselage Trainer (FFT). The FFT is used to familiarize the astronauts with the hardware in the cockpit of the Space Shuttle orbiters. It is one of the mockup training devices located in the Mockup and Integration Laboratory (MAIL) Bldg 9NE. Foale is one of 15 ASCANs recently selected by NASA.

  11. Michael's Marathon: My Experience of Overcoming Illiteracy as an Adult. Literacy Lessons.

    ERIC Educational Resources Information Center

    Marquet, Michael

    Michael Marquet of New Zealand left school 10 years ago, not able to read or write and with a serious speech problem. He had spent 9 years in a special class and had learned very little. He had completed 2 years of high school and left at the end of the fourth form, at the age of 15 and with no qualifications. However, he had participated in a…

  12. Parallel adaptive event horizon finder for numerical relativity

    NASA Astrophysics Data System (ADS)

    Bohn, Andy; Kidder, Lawrence E.; Teukolsky, Saul A.

    2016-09-01

    With Advanced LIGO detecting the gravitational waves emitted from a pair of merging black holes in late 2015, we have a new perspective into the strong field regime of binary black hole systems. Event horizons are the defining features of such black hole spacetimes. We introduce a new code for locating event horizons in numerical simulations based on a Delaunay triangulation on a topological sphere. The code can automatically refine arbitrary regions of the event horizon surface to find and explore features such as the hole in a toroidal event horizon, as discussed in our companion paper. We also investigate various ways of integrating the geodesic equation and find evolution equations that can be integrated efficiently with high accuracy.

  13. Universal properties of the near-horizon optical geometry

    NASA Astrophysics Data System (ADS)

    Gibbons, G. W.; Warnick, C. M.

    2009-03-01

    Making use of the fact that the optical geometry near a static nondegenerate Killing horizon is asymptotically hyperbolic, we investigate some universal features of black-hole horizons. Applying the Gauss-Bonnet theorem allows us to establish some general properties of gravitational lensing, valid for all black holes. Hyperbolic geometry allows us to find rates for the loss of scalar, vector, and fermionic “hair” as objects fall quasistatically towards the horizon, extending previous results for Schwarzschild to all static Killing horizons. In the process we find the Liénard-Wiechert potential for hyperbolic space and calculate the force between electrons mediated by neutrinos, extending the flat space result of Feinberg and Sucher. We further demonstrate how these techniques allow us to derive the exact Copson-Linet potential due to a point charge in a Schwarzschild background in a simple fashion.

  14. Universal properties of the near-horizon optical geometry

    SciTech Connect

    Gibbons, G. W.; Warnick, C. M.

    2009-03-15

    Making use of the fact that the optical geometry near a static nondegenerate Killing horizon is asymptotically hyperbolic, we investigate some universal features of black-hole horizons. Applying the Gauss-Bonnet theorem allows us to establish some general properties of gravitational lensing, valid for all black holes. Hyperbolic geometry allows us to find rates for the loss of scalar, vector, and fermionic ''hair'' as objects fall quasistatically towards the horizon, extending previous results for Schwarzschild to all static Killing horizons. In the process we find the Lienard-Wiechert potential for hyperbolic space and calculate the force between electrons mediated by neutrinos, extending the flat space result of Feinberg and Sucher. We further demonstrate how these techniques allow us to derive the exact Copson-Linet potential due to a point charge in a Schwarzschild background in a simple fashion.

  15. Schwarzschild horizon dynamics and SU(2) Chern-Simons theory

    SciTech Connect

    Kaul, Romesh K.; Majumdar, Parthasarathi

    2011-01-15

    We discuss the effect of different choices in partial gauge fixing of bulk local Lorentz invariance, on the description of the horizon degrees of freedom of a Schwarzschild black hole as an SU(2) Chern-Simons theory with specific sources. A classically equivalent description in terms of an ISO(2) Chern-Simons theory is also discussed. Further, we demonstrate that both of these descriptions can be partially gauge fixed to a horizon theory with U(1) local gauge invariance, with the solder form sources being subject to extra constraints in directions orthogonal to an internal vector field left invariant by U(1) transformations. Seemingly disparate approaches on characterization of the horizon theory for the Schwarzschild black hole (as well as spherical isolated horizons in general) are thus shown to be equivalent physically.

  16. The absence of horizon in black-hole formation

    NASA Astrophysics Data System (ADS)

    Ho, Pei-Ming

    2016-08-01

    With the back-reaction of Hawking radiation taken into consideration, the work of Kawai, Matsuo and Yokokura [1] has shown that, under a few assumptions, the collapse of matter does not lead to event horizon nor apparent horizon. In this paper, we relax their assumptions and elaborate on the space-time geometry of a generic collapsing body with spherical symmetry. The geometry outside the collapsing sphere is found to be approximated by the geometry outside the white-hole horizon, hence the collapsing matter remains outside the Schwarzschild radius. As particles in Hawking radiation are created in the vicinity of the collapsing matter, the information loss paradox is alleviated. Assuming that the collapsing body evaporates within finite time, there is no event horizon.

  17. Horizon Based Orientation Estimation for Planetary Surface Navigation

    NASA Technical Reports Server (NTRS)

    Bouyssounouse, X.; Nefian, A. V.; Deans, M.; Thomas, A.; Edwards, L.; Fong, T.

    2016-01-01

    Planetary rovers navigate in extreme environments for which a Global Positioning System (GPS) is unavailable, maps are restricted to relatively low resolution provided by orbital imagery, and compass information is often lacking due to weak or not existent magnetic fields. However, an accurate rover localization is particularly important to achieve the mission success by reaching the science targets, avoiding negative obstacles visible only in orbital maps, and maintaining good communication connections with ground. This paper describes a horizon solution for precise rover orientation estimation. The detected horizon in imagery provided by the on board navigation cameras is matched with the horizon rendered over the existing terrain model. The set of rotation parameters (roll, pitch yaw) that minimize the cost function between the two horizon curves corresponds to the rover estimated pose.

  18. Note on electrical and thermodynamic properties of isolated horizons

    NASA Astrophysics Data System (ADS)

    Chen, Gerui; Wu, Xiaoning; Gao, Sijie

    2015-03-01

    The electrical laws and Carnot cycle of isolated horizons (IH) are investigated in this paper. We establish Ohm's law and Joule's law of isolated horizons and find that the conceptual picture of black holes (membrane paradigm) can also apply to this kind of quasilocal black holes. We also investigate the geometrical properties near nonrotating IHs and find that under the first-order approximation of r , there exist a Killing vector ∂∂u/ and a Hamiltonian conjugate to it, so this vector can be thought to be a physical observer. We calculate the energy as measured at infinity of a particle at rest outside a nonrotating IH, and we use this result to construct a reversible Carnot cycle with the isolated horizon as a cold reservoir, which confirms the thermodynamic nature of isolated horizons.

  19. Exact event horizon of a black hole merger

    NASA Astrophysics Data System (ADS)

    Emparan, Roberto; Martínez, Marina

    2016-08-01

    We argue that the event horizon of a binary black hole merger, in the extreme-mass-ratio limit where one of the black holes is much smaller than the other, can be described in an exact analytic way. This is done by tracing in the Schwarzschild geometry a congruence of null geodesics that approaches a null plane at infinity. Its form can be given explicitly in terms of elliptic functions, and we use it to analyze and illustrate the time-evolution of the horizon along the merger. We identify features such as the line of caustics at which light rays enter the horizon, and the critical point at which the horizons touch. We also compute several quantities that characterize these aspects of the merger.

  20. The Cauchy horizon singularity inside Kerr black holes

    NASA Astrophysics Data System (ADS)

    Burko, Lior M.; Khanna, Gaurav

    2016-03-01

    The numerical technology that allows for the careful evolution of linearized fields inside Kerr black holes and the study of their behavior approaching the Cauchy horizon singularity includes a number of interesting aspects. The latter include compactified hyperboloidal coordinates and foliation, mixed type hyperbolic-elliptic PDE, and initial data evolution where all equal-coordinate hypersurfaces are spacelike. We review the need for the numerical technology that allows for the solution of the spin-2 Teukolsky equation inside Kerr black holes, and discuss the main features thereof. We present new results about the numerical properties of the Cauchy horizon singularity and their correspondence with the predictions of perturbative analysis. We then discuss present directions of study, which include the sub-dominant azimuthal modes, approaching the Cauchy horizon singularity along timelike directions, approaching the Marolf-Ori (``outflying'') singularity and the studying the fields along the Cauchy horizon.

  1. Entanglement entropy of a black hole and isolated horizon

    NASA Astrophysics Data System (ADS)

    Shi, Jianhua; Hu, Shuangqi; Zhao, Ren

    2013-02-01

    Using Unruh-Verlinde temperature obtained by entropic force, we directly calculate partition functions of quantum field in Schwarzschild spacetime via quantum statistical method and derive the expression of the black hole statistical entropy. In our calculation the lower limit of integral is the location of isolated horizon introduced in loop quantum gravity and the upper limit of integral is infinity. So the obtained entropy is the statistical entropy from isolated horizon to the infinite. In our calculation there are not the cutoff and approximation. The results showed that, as long as proper Immirzi parameters are selected, the entropy obtained by loop quantum gravity is consistent with the quantum statistical entropy outside the black hole horizon. Therefore the black hole entropy is a quantum entanglement entropy outside the isolated horizon.

  2. Grid today, clouds on the horizon

    NASA Astrophysics Data System (ADS)

    Shiers, Jamie

    2009-04-01

    By the time of CCP 2008, the largest scientific machine in the world - the Large Hadron Collider - had been cooled down as scheduled to its operational temperature of below 2 degrees Kelvin and injection tests were starting. Collisions of proton beams at 5+5 TeV were expected within one to two months of the initial tests, with data taking at design energy ( 7+7 TeV) foreseen for 2009. In order to process the data from this world machine, we have put our "Higgs in one basket" - that of Grid computing [The Worldwide LHC Computing Grid (WLCG), in: Proceedings of the Conference on Computational Physics 2006 (CCP 2006), vol. 177, 2007, pp. 219-223]. After many years of preparation, 2008 saw a final "Common Computing Readiness Challenge" (CCRC'08) - aimed at demonstrating full readiness for 2008 data taking, processing and analysis. By definition, this relied on a world-wide production Grid infrastructure. But change - as always - is on the horizon. The current funding model for Grids - which in Europe has been through 3 generations of EGEE projects, together with related projects in other parts of the world, including South America - is evolving towards a long-term, sustainable e-infrastructure, like the European Grid Initiative (EGI) [The European Grid Initiative Design Study, website at http://web.eu-egi.eu/]. At the same time, potentially new paradigms, such as that of "Cloud Computing" are emerging. This paper summarizes the results of CCRC'08 and discusses the potential impact of future Grid funding on both regional and international application communities. It contrasts Grid and Cloud computing models from both technical and sociological points of view. Finally, it discusses the requirements from production application communities, in terms of stability and continuity in the medium to long term.

  3. A celebration of mechanics: from nano to macro. The J. Michael T. Thompson Festschrift issue.

    PubMed

    Elishakoff, Isaac

    2013-06-28

    This Theme Issue is dedicated to the topic 'Mechanics: from nano to macro' and marks the 75th birthday of Dr J. Michael T. Thompson, Fellow of the Royal Society, whose current affiliations are as follows: (i) Honorary Fellow, Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge; (ii) Emeritus Professor of Nonlinear Dynamics, Department of Civil, Environmental and Geomatic Engineering, University College London; and (iii) Professor of Theoretical and Applied Dynamics (Distinguished Sixth Century Chair, part-time), University of Aberdeen. He also serves as Chairman of the Board of Directors at ES-Consult (consulting engineers) in Copenhagen, Denmark. The pertinent question that arises from the very start is: should we first salute Michael and then describe the Theme Issue, or vice versa? Indeed, according to Blaise Pascal (1623-1662), the last thing one discovers in composing a work is what to put first. I would like to take the liberty of deviating from the tradition of the Philosophical Transactions and start with the tribute to Michael; after all he is the prime cause of this Theme Issue.

  4. A horizon scan of global conservation issues for 2015.

    PubMed

    Sutherland, William J; Clout, Mick; Depledge, Michael; Dicks, Lynn V; Dinsdale, Jason; Entwistle, Abigail C; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona A; Monk, Kathryn A; Ockendon, Nancy; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C

    2015-01-01

    This paper presents the results of our sixth annual horizon scan, which aims to identify phenomena that may have substantial effects on the global environment, but are not widely known or well understood. A group of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics via an iterative, Delphi-like process. The topics include a novel class of insecticide compounds, legalisation of recreational drugs, and the emergence of a new ecosystem associated with ice retreat in the Antarctic. PMID:25433442

  5. A horizon scan of global conservation issues for 2013.

    PubMed

    Sutherland, William J; Bardsley, Sarah; Clout, Mick; Depledge, Michael H; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Margerison, Ceri; Monk, Kathryn A; Norris, Kenneth; Peck, Lloyd S; Prior, Stephanie V; Scharlemann, Jörn P W; Spalding, Mark D; Watkinson, Andrew R

    2013-01-01

    This paper presents the findings of our fourth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity. The 15 issues were identified via an iterative, transferable process by a team of professional horizon scanners, researchers, practitioners, and a journalist. The 15 topics include the commercial use of antimicrobial peptides, thorium-fuelled nuclear power, and undersea oil production. PMID:23219597

  6. A horizon scan of global conservation issues for 2013.

    PubMed

    Sutherland, William J; Bardsley, Sarah; Clout, Mick; Depledge, Michael H; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Margerison, Ceri; Monk, Kathryn A; Norris, Kenneth; Peck, Lloyd S; Prior, Stephanie V; Scharlemann, Jörn P W; Spalding, Mark D; Watkinson, Andrew R

    2013-01-01

    This paper presents the findings of our fourth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity. The 15 issues were identified via an iterative, transferable process by a team of professional horizon scanners, researchers, practitioners, and a journalist. The 15 topics include the commercial use of antimicrobial peptides, thorium-fuelled nuclear power, and undersea oil production.

  7. Supertranslations and Superrotations at the Black Hole Horizon.

    PubMed

    Donnay, Laura; Giribet, Gaston; González, Hernán A; Pino, Miguel

    2016-03-01

    We show that the asymptotic symmetries close to nonextremal black hole horizons are generated by an extension of supertranslations. This group is generated by a semidirect sum of Virasoro and Abelian currents. The charges associated with the asymptotic Killing symmetries satisfy the same algebra. When considering the special case of a stationary black hole, the zero mode charges correspond to the angular momentum and the entropy at the horizon.

  8. Supertranslations and Superrotations at the Black Hole Horizon.

    PubMed

    Donnay, Laura; Giribet, Gaston; González, Hernán A; Pino, Miguel

    2016-03-01

    We show that the asymptotic symmetries close to nonextremal black hole horizons are generated by an extension of supertranslations. This group is generated by a semidirect sum of Virasoro and Abelian currents. The charges associated with the asymptotic Killing symmetries satisfy the same algebra. When considering the special case of a stationary black hole, the zero mode charges correspond to the angular momentum and the entropy at the horizon. PMID:26991167

  9. Optical Navigation Preparations for New Horizons Pluto Flyby

    NASA Technical Reports Server (NTRS)

    Owen, William M., Jr.; Dumont, Philip J.; Jackman, Coralie D.

    2012-01-01

    The New Horizons spacecraft will encounter Pluto and its satellites in July 2015. As was the case for the Voyager encounters with Jupiter, Saturn, Uranus and Neptune, mission success will depend heavily on accurate spacecraft navigation, and accurate navigation will be impossible without the use of pictures of the Pluto system taken by the onboard cameras. We describe the preparations made by the New Horizons optical navigators: picture planning, image processing algorithms, software development and testing, and results from in-flight imaging.

  10. Surface Modified Particles By Multi-Step Michael-Type Addition And Process For The Preparation Thereof

    DOEpatents

    Cook, Ronald Lee; Elliott, Brian John; Luebben, Silvia DeVito; Myers, Andrew William; Smith, Bryan Matthew

    2005-05-03

    A new class of surface modified particles and a multi-step Michael-type addition surface modification process for the preparation of the same is provided. The multi-step Michael-type addition surface modification process involves two or more reactions to compatibilize particles with various host systems and/or to provide the particles with particular chemical reactivities. The initial step comprises the attachment of a small organic compound to the surface of the inorganic particle. The subsequent steps attach additional compounds to the previously attached organic compounds through reactive organic linking groups. Specifically, these reactive groups are activated carbon—carbon pi bonds and carbon and non-carbon nucleophiles that react via Michael or Michael-type additions.

  11. Deformation of codimension-2 surfaces and horizon thermodynamics

    NASA Astrophysics Data System (ADS)

    Cao, Li-Ming

    2011-03-01

    The deformation equation of a spacelike submanifold with an arbitrary codimension is given by a general construction without using local frames. In the case of codimension-1, this equation reduces to the evolution equation of the extrinsic curvature of a spacelike hypersurface. In the more interesting case of codimension-2, after selecting a local null frame, this deformation equation reduces to the well known (cross) focusing equations. We show how the thermodynamics of trapping horizons is related to these deformation equations in two different formalisms: with and without introducing quasilocal energy. In the formalism with the quasilocal energy, the Hawking mass in four dimension is generalized to higher dimension, and it is found that the deformation of this energy inside a marginal surface can be also decomposed into the contributions from matter fields and gravitational radiation as in the four dimension. In the formalism without the quasilocal energy, we generalize the definition of slowly evolving future outer trapping horizons proposed by Booth to past trapping horizons. The dynamics of the trapping horizons in FLRW universe is given as an example. Especially, the slowly evolving past trapping horizon in the FLRW universe has close relation to the scenario of slow-roll inflation. Up to the second order of the slowly evolving parameter in this generalization, the temperature (surface gravity) associated with the slowly evolving trapping horizon in the FLRW universe is essentially the same as the one defined by using the quasilocal energy.

  12. Rotating Killing horizons in generic F( R) gravity theories

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Sourav

    2016-10-01

    We discuss various properties of rotating Killing horizons in generic F( R) theories of gravity in dimension four for spacetimes endowed with two commuting Killing vector fields. Assuming there is no curvature singularity anywhere on or outside the horizon, we construct a suitable (3+1)-foliation. We show that similar to Einstein's gravity, we must have T_{ab}k^ak^b=0 on the Killing horizon, where k^a is a null geodesic tangent to the horizon. For axisymmetric spacetimes, the effective gravitational coupling ˜ F'^{-1}(R) should usually depend upon the polar coordinate and hence need not necessarily be a constant on the Killing horizon. We prove that the surface gravity of such a Killing horizon must be a constant, irrespective of whether F'(R) is a constant there or not. We next apply these results to investigate some further basic features. In particular, we show that any hairy solution for the real massive vector field in such theories is clearly ruled out, as long as the potential of the scalar field generated in the corresponding Einstein's frame is a positive definite quantity.

  13. Rh(III)-Catalyzed C-H Bond Addition/Amine-Mediated Cyclization of Bis-Michael Acceptors.

    PubMed

    Potter, Tyler J; Ellman, Jonathan A

    2016-08-01

    A Rh(III)-catalyzed C-H bond addition/primary amine-promoted cyclization of bis-Michael acceptors is reported. The C-H bond addition step occurs with high chemoselectivity, and the subsequent intramolecular Michael addition, mediated by a primary amine catalyst, sets three contiguous stereocenters with high diastereoselectivity. A broad range of directing groups and both aromatic and alkenyl C-H bonds were shown to be effective in this transformation, affording functionalized piperidines, tetrahydropyrans, and cyclohexanes.

  14. Black holes or firewalls: A theory of horizons

    NASA Astrophysics Data System (ADS)

    Nomura, Yasunori; Varela, Jaime; Weinberg, Sean J.

    2013-10-01

    We present a quantum theory of black hole (and other) horizons, in which the standard assumptions of complementarity are preserved without contradicting information theoretic considerations. After the scrambling time, the quantum mechanical structure of a black hole becomes that of an eternal black hole at the microscopic level. In particular, the stretched horizon degrees of freedom and the states entangled with them can be mapped into the near-horizon modes in the two exterior regions of an eternal black hole, whose mass is taken to be that of the evolving black hole at each moment. Salient features arising from this picture include (i) the number of degrees of freedom needed to describe a black hole is eA/2lP2, where A is the area of the horizon; (ii) black hole states having smooth horizons, however, span only an eA/4lP2-dimensional subspace of the relevant eA/2lP2-dimensional Hilbert space; (iii) internal dynamics of the horizon is such that an infalling observer finds a smooth horizon with a probability of 1 if a state stays in this subspace. We identify the structure of local operators responsible for describing semiclassical physics in the exterior and interior spacetime regions and show that this structure avoids the arguments for firewalls—the horizon can keep being smooth throughout the evolution. We discuss the fate of infalling observers under various circumstances, especially when the observers manipulate degrees of freedom before entering the horizon, and we find that an observer can never see a firewall by making a measurement on early Hawking radiation. We also consider the presented framework from the viewpoint of an infalling reference frame and argue that Minkowski-like vacua are not unique. In particular, the number of true Minkowski vacua is infinite, although the label discriminating these vacua cannot be accessed in usual nongravitational quantum field theory. An application of the framework to de Sitter horizons is also discussed.

  15. Effective hydraulic properties on a highly heterogeneous soil horizon

    NASA Astrophysics Data System (ADS)

    Samouëlian, A.; Cousin, I.; Frison, A.; Richard, G.

    2009-04-01

    Knowing the soil hydraulic functioning for agricultural practices is more and more important in the context of global change. In that context, soil horizons represent the reference soil volume in term of soil functioning. Nevertheless they can be heterogeneous as for example, stony horizons, cultivated horizons, or also specific weathering horizons like those in Albeluvisol. The determination of effective hydraulic properties in these heterogeneous horizons can not be done by classical laboratory experiments like Multi-Step-Outflow or evaporative Wind experiment. So it remains a real challenge to get the effective hydraulic properties. The aim of this paper is to propose a methodology for the determination of effective hydraulic properties of heterogeneous soil horizons based on the knowledge of the: on one hand the 3D soil structure and on the other hand the local hydraulic properties. The studied soil is an Albeluvisol that exhibits some horizons composed by the juxtaposition of two Elementary Pedological Volumes (EPVs); they can be visually distinguished by their colours (ochre and white) and they have differential hydraulic functioning: the clayey ochre ones conduct less water than the loamy white ones. Local hydraulic properties were determined on each type of volumes. The 3D structure of the heterogeneous horizon was obtained by electrical resistivity measurements. Several two-dimensional cuts with different structures were extracted from this 3D block so that we can simulate on them the hydraulic functioning of the horizon by the Hydrus2D software. The equivalent water retention curve was obtained thanks to the additive properties of the water retention curves at the local scale. The equivalent unsaturated hydraulic conductivity of the horizon was determined on each 2D cut, which requires the knowledge of the structure. The calculations were done by two methods, a numerical one that simulated the water flow for a constant hydraulic potential, a analytical

  16. Io’s active volcanoes during the New Horizons era: Insights from New Horizons imaging

    NASA Astrophysics Data System (ADS)

    Rathbun, J. A.; Spencer, J. R.; Lopes, R. M.; Howell, R. R.

    2014-03-01

    In February 2007, the New Horizons spacecraft flew by the Jupiter system, obtaining images of Io, the most volcanically active body in the Solar System. The Multicolor Visible Imaging Camera (MVIC), a four-color (visible to near infrared) camera, obtained 17 sets of images. The Long-Range Reconnaissance Imager (LORRI), a high-resolution panchromatic camera, obtained 190 images, including many of Io eclipsed by Jupiter. We present a complete view of the discrete point-like emission sources in all images obtained by these two instruments. We located 54 emission sources and determined their brightnesses. These observations, the first that observed individual Ionian volcanoes on short timescales of seconds to minutes, demonstrate that the volcanoes have stable brightnesses on these timescales. The active volcanoes Tvashtar (63N, 124W) and E. Girru (22N, 245W) were observed by both LORRI and MVIC, both in the near-infrared (NIR) and methane (CH4) filters. Tvashtar was additionally observed in the red filter, which allowed us to calculate a color temperature of approximately 1200 K. We found that, with some exceptions, most of the volcanoes frequently active during the Galileo era continued to be active during the New Horizons flyby. We found that none of the seven volcanoes observed by New Horizons multiple times over short timescales showed substantial changes on the order of seconds and only one, E. Girru exhibited substantial variation over minutes to days, increasing by 25% in just over an hour and decreasing by a factor of 4 over 6 days. Observations of Tvashtar are consistent with a current eruption similar to previously observed eruptions and are more consistent with the thermal emission of a lava flow than the fire fountains inferred from the November 1999 observations. These data also present new puzzles regarding Ionian volcanism. Since there is no associated surface change or low albedo feature that could be identified nearby, the source of the emission from

  17. Genesis of petroduric and petrocalcic horizons in Latinamerica volcanic soils

    NASA Astrophysics Data System (ADS)

    Quantin, Paul

    2010-05-01

    Introduction. In Latinamerica, from Mexico to Chile, there are indurated volcanic soils horizons, named 'tepetate' in Mexico or cangahua in the Andes Mountains. Apart from original volcanic tuffs, these horizons were produced by pedogenesis: either through a former weathering of volcanic ash layers into fragic and later to petrocalcic horizons; or after a former soil formation through a second process of transformation from clayey volcanic soils to silicified petroduric horizons. This oral presentation will briefly deal with the formation of petroduric horizons in Mexico and petrocalcic horizon in Ecuador. Petroduric horizon genesis in Mexico. A soil climato-toposequence, near to Veracruz (Rossignol & Quantin, 1997), shows downwards an evolution from a ferralic Nitisol to a petroduric Durisol. A Durisol profile comports these successive horizons: at the top A and Eg, then columnar Btg-sim, laminar Bt-sim , prismatic Bsim, plinthite Cg, over andesite lava flow. Among its main features are especially recorded: clay mineralogy, microscopy and HRTEM. These data show: an increase in cristobalite at the expenses of 0.7 nm halloysite in Egsiltans, laminar Bt-sim, around or inside the columns or prisms of Btg-sim and Bsimhorizons. HRTEM (Elsass & al 2000) on ultra thin sections reveals an 'epigenesis' of clay sheets by amorphous silica, to form successively A-opal, Ct-opal and microcrystalline cristobalite. From these data and some groundwater chemical analyses, a scenario of duripan formation from a past clayey Nitisol is inferred: clay eluviation-illuviation process? alternate redoximorphy? clay degradation, Al leaching and Si accumulation, to form successively A-opal, Ct-opal and cristobalite. Petrocalcic horizon genesis in Ecuador. A soil climato-toposequence on pyroclastic flows, near to Bolivar in Ecuador (Quantin & Zebrowski, 1997), shows downwards the evolution from fragic-eutric-vitric Cambisols to petrocalcic-vitric Phaeozems, at the piedmont under semi

  18. Intrinsic geometry of a tidally deformed Kerr horizon

    NASA Astrophysics Data System (ADS)

    Poisson, Eric

    2013-04-01

    The intrinsic metric of a tidally deformed black-hole horizon can be presented in a coordinate system adapted to the horizon's null generators, with one coordinate acting as a running parameter along each generator, and two coordinates acting as constant generator labels. The metric is invariant under reparametrizations of the generators, and as such the horizon's intrinsic geometry is known to be gauge invariant. We consider a Kerr black hole deformed by a slowly-evolving external tidal field, and describe the intrinsic geometry of its event horizon in terms of the electric and magnetic tidal moments that characterize the tidal environment. When the black hole is slowly rotating, the horizon's geometry can be described in terms of a deviation from an otherwise spherical surface, and the deformation can be characterized by gauge invariant Love numbers. Some aspects of this tidal deformation have direct analogues in Newtonian physics. Some do not, and I will describe the similarities and differences between the tidal deformation of rotating black holes in general relativity and rotating fluid bodies in Newtonian physics.

  19. Beyond the veil: Inner horizon instability and holography

    SciTech Connect

    Balasubramanian, Vijay; Levi, Thomas S.

    2004-11-15

    We show that scalar perturbations of the eternal, rotating Banados-Teitelboim-Zanelli (BTZ) black hole should lead to an instability of the inner (Cauchy) horizon, preserving strong cosmic censorship. Because of backscattering from the geometry, plane-wave modes have a divergent stress tensor at the event horizon, but suitable wave packets avoid this difficulty, and are dominated at late times by quasinormal behavior. The wave packets have cuts in the complexified coordinate plane that are controlled by requirements of continuity, single-valuedness, and positive energy. Due to a focusing effect, regular wave packets nevertheless have a divergent stress energy at the inner horizon, signaling an instability. We propose that this instability, which is localized behind the event horizon, is detected holographically as a breakdown in the semiclassical computation of dual conformal field theory (CFT) expectation values in which the analytic behavior of wave packets in the complexified coordinate plane plays an integral role. In the dual field theory, this is interpreted as an encoding of physics behind the horizon in the entanglement between otherwise independent CFTs.

  20. Review of the OSHA-NIOSH Response to the Deepwater Horizon Oil Spill: Protecting the Health and Safety of Cleanup Workers

    PubMed Central

    Michaels, David; Howard, John

    2012-01-01

    Introduction: The fire and explosion of the Deepwater Horizon oil rig resulted in an enormous oil spill that threatened large distances of coastline. The overall response was led by the United States Coast Guard and involved the oil company BP, federal agencies, and state and local governments of five states. Methods: The Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health focused extensive resources on ensuring that BP and its contractors provided safe working conditions for thousands of workers involved in the response. Federal personnel visited worksites daily, identifying hazards and means of abatement; assessed training programs to ensure that workers were adequately trained in languages they could understand; monitored chemical exposures and determined that the proper personal protective equipment was deployed; insisted on implementation of a heat mitigation program; rostered thousands of workers; and conducted extensive outreach in communities impacted by the spill. Results: Advance planning, immediate deployment, and collaboration across agencies helped ensure that the response operations resulted in no worker fatalities, and relatively few injuries and illnesses. Conclusions: For future responses, improvements should be made in how safety and health information, as well as the process behind safety and health decisions, are communicated to the public. Citation: Michaels D, Howard J. Review of the OSHA-NIOSH Response to the Deepwater Horizon Oil Spill: Protecting the Health and Safety of Cleanup Workers. PLoS Currents Disasters. 2012 Jul 18 PMID:24678440

  1. Diagnosis: Michael Moore--media paint filmmaker to be health care system's main problem.

    PubMed

    Kao, Caroline

    2008-01-01

    The media reporting on Sicko, Michael Moore's documentary about the failures of the U.S. health care system, provides an example of how corporate media continue to twist and restrict the much-needed debate on health care reform. Aside from an occasional concession that having 46 million uninsured Americans is indeed problematic, the media's hype-filled conversation on health care avoids the issues and echoes old myths about the dangers of "government-run" and "socialized" health care. But in the face of the media demonization, universal health care is remarkably popular among the public. PMID:18341130

  2. Michael E. Lamb: Award for Distinguished Senior Career Contributions to Psychology in the Public Interest.

    PubMed

    2015-11-01

    The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2015 co-recipient of the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest is Michael E. Lamb. Lamb was selected because his "work profoundly shaped the fields of developmental psychology, social welfare, child and family policy, and law." Lamb's award citation, biography, and a selected bibliography are presented here.

  3. A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates.

    PubMed

    Garrabou, Xavier; Beck, Tobias; Hilvert, Donald

    2015-05-01

    Recent advances in computational design have enabled the development of primitive enzymes for a range of mechanistically distinct reactions. Here we show that the rudimentary active sites of these catalysts can give rise to useful chemical promiscuity. Specifically, RA95.5-8, designed and evolved as a retro-aldolase, also promotes asymmetric Michael additions of carbanions to unsaturated ketones with high rates and selectivities. The reactions proceed by amine catalysis, as indicated by mutagenesis and X-ray data. The inherent flexibility and tunability of this catalyst should make it a versatile platform for further optimization and/or mechanistic diversification by directed evolution. PMID:25777153

  4. A summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions.

    PubMed

    Niu, Ben; Xie, Ping; Wang, Min; Wang, Yanjie; Zhao, Wannian; Pittman, Charles U; Zhou, Aihua

    2015-08-01

    A series of seven- and eight-membered ring -N,O-, -N,N-, and -N,S-sultams were effectively synthesized via tandem reactions involving oxa-, aza-, and thia-Michael addition to vinyl sulfonamides. These reactions are summarized here since they enrich current synthetic methodologies for sultams and provide a good example of sultam diversity-oriented synthesis. All reactions proceeded under relatively mild and environmentally friendly conditions, and all these reactions are quite suitable for the rapid preparation of sultam compound libraries, which are valuable for biological activity explorations.

  5. Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis

    PubMed Central

    Lindner, Stephanie; Geu-Flores, Fernando; Bräse, Stefan; Sherden, Nathaniel H.; O’Connor, Sarah E.

    2014-01-01

    Summary The core structure of the iridoid monoterpenes is formed by a unique cyclization reaction. The enzyme that catalyzes this reaction, iridoid synthase, is mechanistically distinct from other terpene cyclases. Here we describe the synthesis of two substrate analogs to probe the mechanism of iridoid synthase. Enzymatic assay of these substrate analogs along with clues from the product profile of the native substrate strongly suggest that iridoid synthase utilizes a Michael reaction to achieve cyclization. This improved mechanistic understanding will facilitate the exploitation of the potential of iridoid synthase to synthesize new cyclic compounds from nonnatural substrates. PMID:25444551

  6. Supported bifunctional thioureas as recoverable and reusable catalysts for enantioselective nitro-Michael reactions

    PubMed Central

    Ceballos, Miriam; Maestro, Alicia; Sanz, Isabel

    2016-01-01

    Summary The catalytic activity of different supported bifunctional thioureas on sulfonylpolystyrene resins has been studied in the nitro-Michael addition of different nucleophiles to trans-β-nitrostyrene derivatives. The activity of the catalysts depends on the length of the tether linking the chiral thiourea to the polymer. The best results were obtained with the thiourea derived from (L)-valine and 1,6-hexanediamine. The catalysts can be used in only 2 mol % loading, and reused for at least four cycles in neat conditions. The ball milling promoted additions also worked very well. PMID:27340453

  7. Construction of highly functionalized diazoacetoacetates via catalytic Mukaiyama-Michael reactions.

    PubMed

    Liu, Yu; Zhang, Yu; Jee, Noel; Doyle, Michael P

    2008-04-17

    Functionalized diazo acetoacetates are prepared by an efficient Mukaiyama-Michael reaction between methyl 3-(trialkylsilanoxy)-2-diazo-3-butenoate and alpha,beta-unsaturated enones. Vinyl ether and ketone derivatives are both accessible in good to excellent yield through this methodology. The mild Lewis acid zinc(II) triflate is the optimal catalyst, and its loading can be as low as 0.1 mol %. In addition, zinc triflate was also found to be a superior catalyst for the related Mukaiyama-aldol reaction.

  8. Densely Substituted L-Proline Esters as Catalysts for Asymmetric Michael Additions of Ketones to Nitroalkenes.

    PubMed

    Ruiz-Olalla, Andrea; Retamosa, María de Gracia; Cossío, Fernando P

    2015-06-01

    Homochiral methyl 4-aminopyrrolidine-2-carboxylates are readily obtained by means of asymmetric (3 + 2) cycloadditions between azomethine ylides and nitroalkenes, followed by catalytic hydrogenation of the intermediate 4-nitro cycloadducts. These 4-aminopyrrolidine-2-carboxylate esters belong to the L-series of natural amino acids and catalyze asymmetric Michael additions of ketones to nitroalkenes. However, the enantioselectivity observed with these novel unnatural organocatalysts is opposite to that obtained with L-proline. Since both 4-nitro and 4-amino L-proline esters are efficient organocatalysts of aldol reactions, these results permit to modulate asymmetric quimioselective aldol and conjugate addition reactions.

  9. Asymmetric anti-selective Michael reaction of imidazole-modified ketones with trans-β-nitroalkenes.

    PubMed

    Yang, Dongxu; Wang, Linqing; Li, Dan; Han, Fengxia; Zhao, Depeng; Wang, Rui

    2015-01-19

    The successful application of imidazole-modified ketones in asymmetric anti-selective Michael reactions with trans-β-nitroalkenes is presented by employing a newly developed 3-bromothiophene-modified chiral diamine ligand. The corresponding conjugate adduct was submitted to further transformations with Grignard reagents to solve the problem of α-site selectivity of simple linear ketones. Additionally, the syn-selective product was obtained by treating the anti-selective adduct with a simple base. In this way, the site-specific products for both diastereomers in the asymmetric conjugate addition of simple ketones to nitroalkenes can be obtained. PMID:25446668

  10. Squaramide-Catalyzed Enantioselective Michael Addition of Masked Acyl Cyanides to Substituted Enones

    PubMed Central

    2013-01-01

    Masked acyl cyanide (MAC) reagents are shown to be effective umpolung synthons for enantioselective Michael addition to substituted enones. The reactions are catalyzed by chiral squaramides and afford adducts in high yields (90–99%) and with excellent enantioselectivities (85–98%). The addition products are unmasked to produce dicyanohydrins that, upon treatment with a variety of nucleophiles, provide γ-keto acids, esters, and amides. The use of this umpolung synthon has enabled, in enantiomerically enriched form, the first total synthesis of the prenylated phenol (+)-fornicin C. PMID:24090310

  11. Michael E. Barnes: Award for Distinguished Professional Contributions to Institutional Practice.

    PubMed

    2012-11-01

    Presents a short biography on the winner of the American Psychological Association's Award for Distinguished Professional Contributions to Institutional Practice. The 2012 winner is Michael E. Barnes for his pioneering leadership, dedication, and distinguished contributions to juvenile justice. As chief psychologist of the Superior Court of the District of Columbia's Child Guidance Clinic, Barnes and his staff have provided exceptional psychological service to thousands of adjudicated youths, developed an APA-accredited internship program, and supervised the development of a juvenile mental health court that diverts mentally ill court-involved youth from delinquency proceedings and into treatment.

  12. STS-113 Mission Specialist Michael Lopez-Alegria suits up for launch

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. - STS-113 Mission Specialist Michael Lopez-Alegria suits up for launch. He will be making his third Shuttle flight. The primary mission for the crew is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for 8:15 p.m. EST.

  13. STS-107 Payload Commander Michael Anderson during TCDT M113 training activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- -- STS-107 Payload Commander Michael Anderson takes a break during training on the operation of an M113 armored personnel carrier during Terminal Countdown Demonstration Test activities, a standard part of launch preparations. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia.

  14. STS-84 M.S. Michael Foale on M-113 carrier at TCDT

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-84 Mission Specialist C. Michael Foale rides in an M-113 armored personnel carrier as part of the Terminal Countdown Demonstration Test (TCDT) activities. STS-84 aboard the Space Shuttle Atlantis will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. After docking, Foale will transfer to the space station and become a member of the Mir 23 crew, replacing U.S. astronaut Jerry M. Linenger, who will return to Earth aboard Atlantis. Foale will live and work on Mir until mid-September when his replacement is expected to arrive on the STS-86 mission. STS-84 is targeted for a May 15 liftoff.

  15. STS-89 Mission Specialist Michael Anderson is assisted with his flight suit in the white room

    NASA Technical Reports Server (NTRS)

    1998-01-01

    STS-89 Mission Specialist Michael Anderson is assisted with his ascent and re-entry flight suit in the white room at Launch Pad 39A before entering Space Shuttle Endeavour for launch. The STS- 89 mission will be the eighth docking of the Space Shuttle with the Russian Space Station Mir. After docking, Mission Specialist Andrew Thomas, Ph.D., will transfer to the space station, succeeding David Wolf, M.D., who will return to Earth aboard Endeavour. Dr. Thomas will live and work on Mir until June. STS- 89 is scheduled for a Jan. 22 liftoff at 9:48 p.m.

  16. STS-113 Mission Specialist Michael Lopez-Alegria suits up before launch

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria suits up before launch. This will be his third Shuttle flight. The primary mission is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for Nov. 11 at 12:58 a.m. EST.

  17. Michael Servetus (1511-1553): physician and heretic who described the pulmonary circulation.

    PubMed

    Bosmia, Anand; Watanabe, Koichi; Shoja, Mohammadali M; Loukas, Marios; Tubbs, R Shane

    2013-07-31

    The purpose of this paper is to provide an overview of the life of the physician and theologian Michael Servetus and to discuss his analysis of the pulmonary circulation. Writers have praised Servetus for his commitment to educating his colleagues about what he heralded as the truth, and criticized him for his perceived arrogance. Servetus made contributions to the fields of geography, astrology, theology, and medicine. This paper refers to the translation of a portion of Servetus' book Christianismi Restitutio by Charles D. O'Malley. PMID:22748500

  18. New Horizons at Pluto: Asking the right questions

    NASA Astrophysics Data System (ADS)

    Young, Leslie; Stern, S. Alan; Olkin, Catherine B.; Spencer, John R.; Cheng, Andrew F.; Weaver, Harold A.; Ennico, Kimberly; Moore, Jeffrey M.; Grundy, William M.; Bagenal, Fran; Gladstone, Randy; Lunine, Jonathan I.; New Horizons Science Team

    2016-10-01

    In the 1980's and 1990's, breakthroughs about Pluto and the outer solar system laid the groundwork for the Outer Planets Science Working Group (1992), the Pluto Kuiper Express mission Science Definition Team (1996), and the Announcement of Opportunity for the Pluto Kuiper-Belt mission in 2001. These included specific science goals that molded the mission design, instrument selection, and observing sequence. These goals held up amazingly well over the decades. This historical review of New Horizons will explain how ground-based and theoretical work prepared us for a successful investigation of Pluto, and speculate on some of the new questions raised by the New Horizons flyby of the Pluto system.This work was supported by NASA's New Horizons project.

  19. Stability of the black hole horizon and the Landau ghost

    SciTech Connect

    Bekenstein, J.D.; Rosenzweig, C. )

    1994-12-15

    The stability of the black hole horizon is demanded by both cosmic censorship and the generalized second law of thermodynamics. We test the consistency of these principles by attempting to exceed the black hole extremality condition in various processes in which a U(1) charge is added to a nearly extreme Reissner-Nordstroem black hole charged with a [ital different] type of U(1) charge. For an infalling spherical charged shell the attempt is foiled by the self-Coulomb repulsion of the shell. For an infalling classical charge it fails because the required classical charge radius exceeds the size of the black hole. For a quantum charge the horizon is saved because, in order to aviod the Landau ghost, the effective coupling constant cannot be large enough to accomplish the removal of the horizon.

  20. Black hole thermodynamics from near-horizon conformal quantum mechanics

    SciTech Connect

    Camblong, Horacio E.; Ordonez, Carlos R.

    2005-05-15

    The thermodynamics of black holes is shown to be directly induced by their near-horizon conformal invariance. This behavior is exhibited using a scalar field as a probe of the black hole gravitational background, for a general class of metrics in D spacetime dimensions (with D{>=}4). The ensuing analysis is based on conformal quantum mechanics, within a hierarchical near-horizon expansion. In particular, the leading conformal behavior provides the correct quantum statistical properties for the Bekenstein-Hawking entropy, with the near-horizon physics governing the thermodynamics from the outset. Most importantly: (i) this treatment reveals the emergence of holographic properties; (ii) the conformal coupling parameter is shown to be related to the Hawking temperature; and (iii) Schwarzschild-like coordinates, despite their 'coordinate singularity', can be used self-consistently to describe the thermodynamics of black holes.

  1. Priority Questions and Horizon Scanning for Conservation: A Comparative Study.

    PubMed

    Kark, Salit; Sutherland, William J; Shanas, Uri; Klass, Keren; Achisar, Hila; Dayan, Tamar; Gavrieli, Yael; Justo-Hanani, Ronit; Mandelik, Yael; Orion, Nir; Pargament, David; Portman, Michelle; Reisman-Berman, Orna; Safriel, Uriel N; Schaffer, Gad; Steiner, Noa; Tauber, Israel; Levin, Noam

    2016-01-01

    Several projects aimed at identifying priority issues for conservation with high relevance to policy have recently been completed in several countries. Two major types of projects have been undertaken, aimed at identifying (i) policy-relevant questions most imperative to conservation and (ii) horizon scanning topics, defined as emerging issues that are expected to have substantial implications for biodiversity conservation and policy in the future. Here, we provide the first overview of the outcomes of biodiversity and conservation-oriented projects recently completed around the world using this framework. We also include the results of the first questions and horizon scanning project completed for a Mediterranean country. Overall, the outcomes of the different projects undertaken (at the global scale, in the UK, US, Canada, Switzerland and in Israel) were strongly correlated in terms of the proportion of questions and/or horizon scanning topics selected when comparing different topic areas. However, some major differences were found across regions. There was large variation among regions in the percentage of proactive (i.e. action and response oriented) versus descriptive (non-response oriented) priority questions and in the emphasis given to socio-political issues. Substantial differences were also found when comparing outcomes of priority questions versus horizon scanning projects undertaken for the same region. For example, issues related to climate change, human demography and marine ecosystems received higher priority as horizon scanning topics, while ecosystem services were more emphasized as current priority questions. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. We propose that further emphasis on social-political issues should be explicitly integrated into future

  2. Priority Questions and Horizon Scanning for Conservation: A Comparative Study

    PubMed Central

    Kark, Salit; Sutherland, William J.; Shanas, Uri; Klass, Keren; Achisar, Hila; Dayan, Tamar; Gavrieli, Yael; Justo-Hanani, Ronit; Mandelik, Yael; Orion, Nir; Pargament, David; Portman, Michelle; Reisman-Berman, Orna; Safriel, Uriel N.; Schaffer, Gad; Steiner, Noa; Tauber, Israel; Levin, Noam

    2016-01-01

    Several projects aimed at identifying priority issues for conservation with high relevance to policy have recently been completed in several countries. Two major types of projects have been undertaken, aimed at identifying (i) policy-relevant questions most imperative to conservation and (ii) horizon scanning topics, defined as emerging issues that are expected to have substantial implications for biodiversity conservation and policy in the future. Here, we provide the first overview of the outcomes of biodiversity and conservation-oriented projects recently completed around the world using this framework. We also include the results of the first questions and horizon scanning project completed for a Mediterranean country. Overall, the outcomes of the different projects undertaken (at the global scale, in the UK, US, Canada, Switzerland and in Israel) were strongly correlated in terms of the proportion of questions and/or horizon scanning topics selected when comparing different topic areas. However, some major differences were found across regions. There was large variation among regions in the percentage of proactive (i.e. action and response oriented) versus descriptive (non-response oriented) priority questions and in the emphasis given to socio-political issues. Substantial differences were also found when comparing outcomes of priority questions versus horizon scanning projects undertaken for the same region. For example, issues related to climate change, human demography and marine ecosystems received higher priority as horizon scanning topics, while ecosystem services were more emphasized as current priority questions. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. We propose that further emphasis on social-political issues should be explicitly integrated into future

  3. Priority Questions and Horizon Scanning for Conservation: A Comparative Study.

    PubMed

    Kark, Salit; Sutherland, William J; Shanas, Uri; Klass, Keren; Achisar, Hila; Dayan, Tamar; Gavrieli, Yael; Justo-Hanani, Ronit; Mandelik, Yael; Orion, Nir; Pargament, David; Portman, Michelle; Reisman-Berman, Orna; Safriel, Uriel N; Schaffer, Gad; Steiner, Noa; Tauber, Israel; Levin, Noam

    2016-01-01

    Several projects aimed at identifying priority issues for conservation with high relevance to policy have recently been completed in several countries. Two major types of projects have been undertaken, aimed at identifying (i) policy-relevant questions most imperative to conservation and (ii) horizon scanning topics, defined as emerging issues that are expected to have substantial implications for biodiversity conservation and policy in the future. Here, we provide the first overview of the outcomes of biodiversity and conservation-oriented projects recently completed around the world using this framework. We also include the results of the first questions and horizon scanning project completed for a Mediterranean country. Overall, the outcomes of the different projects undertaken (at the global scale, in the UK, US, Canada, Switzerland and in Israel) were strongly correlated in terms of the proportion of questions and/or horizon scanning topics selected when comparing different topic areas. However, some major differences were found across regions. There was large variation among regions in the percentage of proactive (i.e. action and response oriented) versus descriptive (non-response oriented) priority questions and in the emphasis given to socio-political issues. Substantial differences were also found when comparing outcomes of priority questions versus horizon scanning projects undertaken for the same region. For example, issues related to climate change, human demography and marine ecosystems received higher priority as horizon scanning topics, while ecosystem services were more emphasized as current priority questions. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. We propose that further emphasis on social-political issues should be explicitly integrated into future

  4. Spores, pollen, and microplankton from the horizon Beta outcrop.

    PubMed

    Habib, D

    1968-12-27

    Palynology was used for dating a pre-Pleistocene deep-sea organic lutite layer situated stratigraphically near seismic horizon beta, below horizon A. The spores and pollen are closely identified, quantitatively, with nonmarine and marine Middle Cretaceous assemblages (Albian-Cenomanian) on the continents, an age designation that is confirmed by the occurrence of dinoflagellate cysts, acritarchs, foraminifers, and coccoliths in the investigated cores. The abundance of these well-preserved, land-derived assemblages in an area far removed from a source suggests some tectonic displacement since their deposition.

  5. Robust Consumption-Investment Problem on Infinite Horizon

    SciTech Connect

    Zawisza, Dariusz

    2015-12-15

    In our paper we consider an infinite horizon consumption-investment problem under a model misspecification in a general stochastic factor model. We formulate the problem as a stochastic game and finally characterize the saddle point and the value function of that game using an ODE of semilinear type, for which we provide a proof of an existence and uniqueness theorem for its solution. Such equation is interested on its own right, since it generalizes many other equations arising in various infinite horizon optimization problems.

  6. Earth, Meet Pluto: The New Horizons Education and Communications Partnership

    NASA Astrophysics Data System (ADS)

    Buckley, M.

    2015-12-01

    The unique partnership between the NASA New Horizons education/communications and public affairs programs tapped into the excitement of visiting an unexplored planet in a new region of the solar system - resulting in unprecedented public participation in and coverage of a planetary mission. With a range of hands-on learning experiences, Web materials and online , the program provided opportunities for students, educators, museums, science centers, the media, Web surfers and other members of the public to ride along on the first mission to Pluto and the Kuiper Belt. The programs leveraged resources, materials and expertise to address a wide range of traditional and nontraditional audiences while providing consistent messages and information on this historic NASA endeavor. The E/C program included a variety of formal lesson plans and learning materials — based on New Horizons science and engineering goals, and aligned with National Research Council's National Science Education Standards — that continue to help students in grades K-12 learn more about science, technology, engineering and mathematics. College students designed and built an actual flight instrument on New Horizons and held internships with the spacecraft integration and test team. New Horizons E/C programs went well beyond the classroom, from a chance for people to send their names to Pluto on board the New Horizons spacecraft before launch, to opportunities for the public to access milestone events and the first-ever close-up views of Pluto in places such as museums, science centers and libraries, TV and the Web — as well as thousands who attended interactive "Plutopalooza" road shows across the country. Teamed with E/C was the public affairs strategy to communicate New Horizons news and messages to media, mission stakeholders, the scientific community and the public. These messages include various aspects of New Horizons, including the progress of the mission and key milestones and achievements

  7. A horizon scan of global conservation issues for 2014

    PubMed Central

    Sutherland, William J.; Aveling, Rosalind; Brooks, Thomas M.; Clout, Mick; Dicks, Lynn V.; Fellman, Liz; Fleishman, Erica; Gibbons, David W.; Keim, Brandon; Lickorish, Fiona; Monk, Kathryn A.; Mortimer, Diana; Peck, Lloyd S.; Pretty, Jules; Rockström, Johan; Rodríguez, Jon Paul; Smith, Rebecca K.; Spalding, Mark D.; Tonneijck, Femke H.; Watkinson, Andrew R.

    2014-01-01

    This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease. PMID:24332318

  8. New Horizons: Gas and Plasma in the Pluto System

    NASA Astrophysics Data System (ADS)

    Young, Leslie; Gladstone, Randy; Summers, Michael; Bagenal, Fran; Stern, S. Alan; Weaver, Harold A.; Olkin, Catherine B.; Ennico, Kimberly; Moore, Jeffrey M.; Grundy, William M.; New Horizons Atmospheres Science Theme Team, New Horizons Particles and Plasma Science Theme Team

    2016-10-01

    NASA's New Horizons mission gave us information about gas and plasma in the Pluto system from Pluto's surface up to a distance of ~200,000 km beyond Pluto. This review will give an overview of our current theories and observations of the near-surface atmospheric structure; the properties, production and settling of Pluto's ubiquitous haze; the minor atmospheric species and atmospheric chemistry; the energetics and high-altitude thermal structure; the escape rate and the pickup of methane ions; the effect of methane impacting Charon; and Pluto's heavy-ion tail. Details are given in other presentations at this conference.This work was supported by NASA's New Horizons project.

  9. A horizon scan of global conservation issues for 2014.

    PubMed

    Sutherland, William J; Aveling, Rosalind; Brooks, Thomas M; Clout, Mick; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Monk, Kathryn A; Mortimer, Diana; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Rodríguez, Jon Paul; Smith, Rebecca K; Spalding, Mark D; Tonneijck, Femke H; Watkinson, Andrew R

    2014-01-01

    This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease. PMID:24332318

  10. A Horizon Scan of Global Conservation Issues for 2016.

    PubMed

    Sutherland, William J; Broad, Steven; Caine, Jacqueline; Clout, Mick; Dicks, Lynn V; Doran, Helen; Entwistle, Abigail C; Fleishman, Erica; Gibbons, David W; Keim, Brandon; LeAnstey, Becky; Lickorish, Fiona A; Markillie, Paul; Monk, Kathryn A; Mortimer, Diana; Ockendon, Nancy; Pearce-Higgins, James W; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C; Wright, Katherine E

    2016-01-01

    This paper presents the results of our seventh annual horizon scan, in which we aimed to identify issues that could have substantial effects on global biological diversity in the future, but are not currently widely well known or understood within the conservation community. Fifteen issues were identified by a team that included researchers, practitioners, professional horizon scanners, and journalists. The topics include use of managed bees as transporters of biological control agents, artificial superintelligence, electric pulse trawling, testosterone in the aquatic environment, building artificial oceanic islands, and the incorporation of ecological civilization principles into government policies in China. PMID:26688445

  11. Spectral properties of acoustic black hole radiation: Broadening the horizon

    SciTech Connect

    Finazzi, Stefano; Parentani, Renaud

    2011-04-15

    The sensitivity of the black hole spectrum when introducing short distance dispersion is studied in the context of atomic Bose condensates. By considering flows characterized by several length scales, we show that, while the spectrum remains remarkably Planckian, the temperature is no longer fixed by the surface gravity. Rather it is determined by the average of the flow gradient across the horizon over an interval fixed by the healing length and the surface gravity, as if the horizon were broadened. This remains valid as long as the flow does not induce nonadiabatic effects that produce oscillations or some parametric amplification of the flux.

  12. A Horizon Scan of Global Conservation Issues for 2016.

    PubMed

    Sutherland, William J; Broad, Steven; Caine, Jacqueline; Clout, Mick; Dicks, Lynn V; Doran, Helen; Entwistle, Abigail C; Fleishman, Erica; Gibbons, David W; Keim, Brandon; LeAnstey, Becky; Lickorish, Fiona A; Markillie, Paul; Monk, Kathryn A; Mortimer, Diana; Ockendon, Nancy; Pearce-Higgins, James W; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C; Wright, Katherine E

    2016-01-01

    This paper presents the results of our seventh annual horizon scan, in which we aimed to identify issues that could have substantial effects on global biological diversity in the future, but are not currently widely well known or understood within the conservation community. Fifteen issues were identified by a team that included researchers, practitioners, professional horizon scanners, and journalists. The topics include use of managed bees as transporters of biological control agents, artificial superintelligence, electric pulse trawling, testosterone in the aquatic environment, building artificial oceanic islands, and the incorporation of ecological civilization principles into government policies in China.

  13. A horizon scan of global conservation issues for 2014.

    PubMed

    Sutherland, William J; Aveling, Rosalind; Brooks, Thomas M; Clout, Mick; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Monk, Kathryn A; Mortimer, Diana; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Rodríguez, Jon Paul; Smith, Rebecca K; Spalding, Mark D; Tonneijck, Femke H; Watkinson, Andrew R

    2014-01-01

    This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease.

  14. Toroidal Event Horizons in Binary Black Hole Mergers

    NASA Astrophysics Data System (ADS)

    Bohn, Andy; Teukolsky, Saul; Kidder, Lawrence; Simulating eXtreme Spacetimes Collaboration

    2016-03-01

    We find the first binary black hole (BBH) event horizon with a short-lived toroidal topology. The BBH mergers are produced using the Spectral Einstein Code (SpEC). It is expected that a toroidal topology should appear in space-like slicings of these 2 + 1 dimensional event horizons, but this topology has not been found previously. While we do not see a toroidal phase in the generalized harmonic slicing used to simulate the BBHs, we do find a toroidal phase after using a motivated coordinate transformation to another space-like slicing.

  15. Generalized Robertson-Walker Space-Time Admitting Evolving Null Horizons Related to a Black Hole Event Horizon

    PubMed Central

    2016-01-01

    A new technique is used to study a family of time-dependent null horizons, called “Evolving Null Horizons” (ENHs), of generalized Robertson-Walker (GRW) space-time (M¯,g¯) such that the metric g¯ satisfies a kinematic condition. This work is different from our early papers on the same issue where we used (1 + n)-splitting space-time but only some special subcases of GRW space-time have this formalism. Also, in contrast to previous work, we have proved that each member of ENHs is totally umbilical in (M¯,g¯). Finally, we show that there exists an ENH which is always a null horizon evolving into a black hole event horizon and suggest some open problems. PMID:27722202

  16. Through the looking glass: why the `cosmic horizon' is not a horizon

    NASA Astrophysics Data System (ADS)

    van Oirschot, Pim; Kwan, Juliana; Lewis, Geraint F.

    2010-06-01

    The present standard model of cosmology, Λ cold dark matter (ΛCDM), contains some intriguing coincidences. Not only are the dominant contributions to the energy density approximately of the same order at the present epoch, but we also note that contrary to the emergence of cosmic acceleration as a recent phenomenon, the time-averaged value of the deceleration parameter over the age of the Universe is nearly zero. Curious features like these in ΛCDM give rise to a number of alternate cosmologies being proposed to remove them, including models with an equation of state w = -1/3. In this paper, we examine the validity of some of these alternate models and we also address some persistent misconceptions about the Hubble sphere and the event horizon that lead to erroneous conclusions about cosmology. Research undertaken as part of the Commonwealth Cosmology Initiative (CCI: http://www.thecci.org), an international collaboration supported by the Australian Research Council. E-mail: pimvanoirschot@gmail.com

  17. Cinchona Alkaloid Catalyzed Sulfa-Michael Addition Reactions Leading to Enantiopure β-Functionalized Cysteines.

    PubMed

    Breman, Arjen C; Telderman, Suze E M; van Santen, Roy P M; Scott, Jamie I; van Maarseveen, Jan H; Ingemann, Steen; Hiemstra, Henk

    2015-11-01

    Sulfa-Michael additions to α,β-unsaturated N-acylated oxazolidin-2-ones and related α,β-unsaturated α-amino acid derivatives have been enantioselectively catalyzed by Cinchona alkaloids functionalized with a hydrogen bond donating group at the C6' position. The series of Cinchona alkaloids includes known C6' (thio)urea and sulfonamide derivatives and several novel species with a benzimidazole, squaramide or a benzamide group at the C6' position. The sulfonamides were especially suited as bifunctional organocatalysts as they gave the products in very good diastereoselectivity and high enantioselectivity. In particular, the C6' sulfonamides catalyzed the reaction with the α,β-unsaturated α-amino acid derivatives to afford the products in a diastereomeric ratio as good as 93:7, with the major isomer being formed in an ee of up to 99%. The products of the organocatalytic sulfa-Michael addition to α,β-unsaturated α-amino acid derivatives were subsequently converted in high yields to enantiopure β-functionalized cysteines suitable for native chemical ligation.

  18. Sustained release formulation of erythropoietin using hyaluronic acid hydrogels crosslinked by Michael addition.

    PubMed

    Hahn, Sei Kwang; Oh, Eun Ju; Miyamoto, Hajime; Shimobouji, Tsuyoshi

    2006-09-28

    A novel sustained release formulation of erythropoietin (EPO) was successfully developed using hyaluronic acid (HA) hydrogels crosslinked by Michael addition. Adipic acid dihydrazide grafted HA (HA-ADH) was prepared and then modified into methacrylated HA (HA-MA). (1)H NMR analysis showed that the degrees of HA-ADH and HA-MA modification were 69 and 29 mol%, respectively. Using the specific crosslinkers of dithiothreitol (DTT) and peptide linker, EPO was loaded during HA-MA hydrogel preparation by Michael addition chemistry between thiol and methacrylate groups. The amount of EPO recovered from both hydrogels after degradation with hyaluronidase SD (HAse SD) was about 90%. The crosslinking reaction with peptide linker (GCYKNRDCG) was faster than that with DTT. The gelation time was about 30 min for peptide linker and 180 min for DTT. In vitro release test of EPO from HA-MA hydrogel at 37 degrees C showed that EPO was released rapidly for 2 days and then slowly up to 7 days from HA-MA hydrogels. The released EPO appeared to be intact from the analysis with RP-HPLC. According to in vivo release test of EPO from HA-MA hydrogels crosslinked with the peptide linker in Sprague-Dawley (SD) rats, elevated plasma concentration of EPO was maintained up to 7 days. There was no adverse effect during and after the in vivo tests. PMID:16781096

  19. Tuning the stereoselectivity of a DNA-catalyzed michael addition through covalent modification.

    PubMed

    Dey, Surjendu; Jäschke, Andres

    2015-09-14

    Complexes of G-quadruplex DNA and Cu(II) ions have previously been applied as catalysts in asymmetric reactions, but the largely unspecific and noncovalent nature of the interaction has impeded understanding of the structural basis of catalysis. To better control the formation of a catalytically competent species, DNA quadruplexes were derivatized with linker-bpy-Cu(II) complexes in a site-specific manner and applied in asymmetric aqueous Michael additions. These modified quadruplexes exhibited high rate acceleration and stereoselectivity. Different factors were found to be important for the catalytic performance of the modified G-quadruplexes, among them, the position of modification, the topology of the quadruplex, the nature of the ligand, and the length of the linker between the ligand and DNA. Moving the same ligand by just two nucleotides inverted the stereochemical outcome: quadruplexes modified at position 10 formed the (-)-enantiomer with up to 92 % ee, while DNA derivatized at position 12 formed the (+)-enantiomer with up to 75 % ee. This stereopreference was maintained when applied to structurally different Michael acceptors. This work demonstrates a new and simple way to tune the stereoselectivity in DNA-based asymmetric catalysis.

  20. Evaluation of GPS Coverage for the X-33 Michael-6 Trajectory

    NASA Technical Reports Server (NTRS)

    Lundberg, John B.

    1998-01-01

    The onboard navigational system for the X-33 test flights will be based on the use of measurements collected from the Embedded Global Positioning System (GPS)/INS system. Some of the factors which will affect the quality of the GPS contribution to the navigational solution will be the number of pseudorange measurements collected at any instant in time, the distribution of the GPS satellites within the field of view, and the inherent noise level of the GPS receiver. The distribution of GPS satellites within the field of view of the receiver's antenna will depend on the receiver's position, the time of day, pointing direction of the antenna, and the effective cone angle of the antenna. The number of pseudorange measurements collected will depend upon these factors as well as the time required to lock onto a GPS satellite signal once the GPS satellite comes into the field of view of the antenna and the number of available receiver channels. The objective of this study is to evaluate the GPS coverage resulting from the proposed antenna pointing directions, the proposed antenna cone angles, and the effects due to the time of day for the X-33 Michael-6 trajectory from launch at Edwards AFB, California, to the start of the Terminal Area Energy Management (TAEM) phase on approach to Michael AAF, Utah.

  1. Base-dependent stereodivergent intramolecular aza-Michael reaction: asymmetric synthesis of 1,3-disubstituted isoindolines.

    PubMed

    Fustero, Santos; Herrera, Lidia; Lázaro, Ruben; Rodríguez, Elsa; Maestro, Miguel A; Mateu, Natalia; Barrio, Pablo

    2013-08-26

    The nucleophilic addition (A(N)) / intramolecular aza-Michael reaction (IMAMR) process on Ellman's tert-butylsulfinyl imines, bearing a Michael acceptor in the ortho position, is studied. This reaction affords 1,3-disubstituted isoindolines with a wide range of substituents in good yields and diastereoselectivities. Interestingly, careful choice of the base for the aza-Michael step allows either the cis or the trans diastereoisomers to be exclusively obtained. This stereodivergent cyclization has enabled the synthesis of C2-symmetric bisacetate-substituted isoindolines. In addition, bisacetate isoindolines bearing two well-differentiated ester moieties are also noteworthy because they may allow for the orthogonal synthesis of β,β'-dipeptides using a single nitrogen atom as a linchpin.

  2. Ecological Impacts During the Deepwater Horizon Oil Spill Response

    EPA Science Inventory

    The Deepwater Horizon (DWH) oil spill was the largest environmental disaster and response effort in U.S. history, with nearly 800 million liters of crude oil spilled. Vast areas of the Gulf of Mexico were contaminated with oil, including deep-ocean communities and over 1,600 kilo...

  3. Survey of New Horizons International Music Association Musicians

    ERIC Educational Resources Information Center

    Coffman, Don

    2009-01-01

    This study analysed survey responses from 1652 New Horizons International Music Association (NHIMA) musicians in the United States and Canada to better understand older adults' experiences in making music. The purpose of this study was threefold: (a) ascertain the extent of NHIMA musicians' musical backgrounds and their current involvement in…

  4. Copper distribution in surface and subsurface soil horizons.

    PubMed

    Arenas-Lago, Daniel; Vega, Flora A; Silva, Luis Felipe O; Andrade, María Luisa

    2014-09-01

    The horizons of four natural soils were treated with Cu(2+) in an acid medium to study the retention capacity of Cu. The possible mineralogical changes arising because of the treatment were also studied. The soil properties and characteristics with the greatest influence on the metal retention and its distribution among the different soil fractions were determined. Crystalline phases of each horizon were determined by X-ray diffraction (XDR). The morphology, structural distribution and particle chemical composition of soil samples were investigated using field emission scanning electron microscopy. Cu distribution in the different geochemical phases of the soil was studied using a sequential extraction. The treatment led to an increase in the amorphous phases and the formation of new crystalline phases, such as rouaite (Cu2(NO3)(OH)3) and nitratine (NaNO3). Cu was also found superficially sorbed on amorphous hydroxy compounds of Fe that interact with albite, muscovite and gibbsite, and also on spherical and curved particles of aluminium clays. The largest amount of Cu retained was in an exchangeable form, and the smallest amount associated with the crystalline Fe oxides and residual fraction. In the surface horizons, the predominant Cu retention process is complexation in organomineral associations, while in the subsurface horizons it is adsorption.

  5. Ecological impacts of the Deepwater Horizon oil spill

    EPA Science Inventory

    The Deepwater Horizon oil spill (DWH) was the largest environmental disaster and response effort in United States history, with nearly 800 million liters of crude oil spilled. Vast areas of the Gulf of Mexico were contaminated with oil, including deep ocean communities and over 1...

  6. Star/horizon simulator used to test space guidance system

    NASA Technical Reports Server (NTRS)

    Schmidt, W. C.

    1967-01-01

    Star/horizon simulator is used for alignment and optical plus photoelectric tests of the sextant for the Apollo guidance and navigation system optical unit assembly. The unit is basically a refractive collimator with a two inch objective lens system and a twenty-four inch focal length.

  7. Breaking an Abelian gauge symmetry near a black hole horizon

    SciTech Connect

    Gubser, Steven S.

    2008-09-15

    I argue that coupling the Abelian Higgs model to gravity plus a negative cosmological constant leads to black holes which spontaneously break the gauge invariance via a charged scalar condensate slightly outside their horizon. This suggests that black holes can superconduct.

  8. New Horizons: An Empowerment Program for Egyptian Adolescent Girls.

    ERIC Educational Resources Information Center

    Swanson, Julie Hanson

    New Horizons is a nonschool program that demystifies and communicates essential information on basic life skills and reproductive health to Egyptian girls and young women aged 9-20. The program consists of 100 hour-long sessions, each including an introduction to a specific topic, review of group knowledge level, discussion around key points…

  9. Community Colleges Broadening Horizons through Service Learning, 2006-2009

    ERIC Educational Resources Information Center

    Robinson, Gail

    2007-01-01

    This brief introduces "Community Colleges Broadening Horizons through Service Learning," the American Association of Community Colleges' (AACC's) fifth national Learn and Serve America grant project and describes its grantee college programs. The goals of this grant project are to build on established foundations to integrate service learning…

  10. A MIP Model for Rolling Horizon Surgery Scheduling.

    PubMed

    Luo, Li; Luo, Yong; You, Yang; Cheng, Yuanjun; Shi, Yingkang; Gong, Renrong

    2016-05-01

    Most surgery scheduling is done 1 day in advance. Caused by lack of overall planning, this scheduling scheme often results in unbalanced occupancy time of the operating rooms. So we put forward a rolling horizon mixed integer programming model for the scheduling. Rolling horizon scheduling refers to a scheduling scheme in which cyclic surgical requests are taken into account. Surgical requests are updated daily. The completed surgeries are eliminated, and new surgeries are added to the scheduling list. Considering day-to-day demand for surgery, we develop a non-rolling scheduling model (NRSM) and a rolling horizon scheduling model (RSM). By comparing the two, we find that the quality of surgery scheduling is significantly influenced by the variation in demand from day to day. A rolling horizon scheduling will enable a more flexible planning of the pool of surgeries that have not been scheduled into this main blocks, and hence minimize the idle time of operating rooms. The strategy of the RSM helps balance the occupancy time among operating rooms. Using surgical data from five departments of the West China Hospital (WCH), we generate surgical demands randomly to compare the NRSM and the RSM. The results show the operating rooms' average utilization rate using RSM is significantly higher than when applying NRSM.

  11. Marriage Horizons at Woodstock--A Revised Approach.

    PubMed

    Parker, Brian

    2015-01-01

    The double logarithmic straight-line representation of marriage horizon data is a useful tool for their comparison. Current practice is to exclude intra-parochial couples from the calculations. This note argues that these couples should be included and demonstrates that the results of doing so produce significantly improved correlation coefficients.

  12. Ecological Impacts during the Deepwater Horizon Oil Spill

    EPA Science Inventory

    The Deepwater Horizon (DWH) oil spill was the largest spill and response effort in United States history. Nearly 800 million L of oil was spilled in the Gulf of Mexico, and nearly 7 million L of chemical dispersants were applied in at the ocean surface and subsea1. The DWH spill ...

  13. Solution to the cosmological horizon problem proposed by Zee

    SciTech Connect

    Pollock, M.D.

    1981-08-15

    Applying a theory of gravity with broken symmetry, Zee has suggested a solution to the cosmological horizon problem. His idea has been criticized on two independent grounds by Linde and by Sato. In this paper, we suggest answers to both these criticisms.

  14. Knowledge Concerning the Mathematical Horizon: A Close View

    ERIC Educational Resources Information Center

    Guberman, Raisa; Gorev, Dvora

    2015-01-01

    The main objective of this study is to identify components of teachers' mathematical knowledge for teaching, associated with the knowledge of mathematical horizon (KMH) in order to describe this type of knowledge from the viewpoint of elementary school mathematics teachers. The research population of this study consisted of 118 elementary school…

  15. Ecological Impacts of the Deepwater Horizon Oil Spill (Bogota, Columbia)

    EPA Science Inventory

    The Deepwater Horizon oil spill (DWH) was the largest environmental disaster and response effort in US History, with nearly 800 million liters spilled. Vast areas of the Gulf of Mexico were contaminated with oil, including deep ocean communities, protected species, over 1600 km o...

  16. Rethinking Classroom Management: A New Perspective, a New Horizon

    ERIC Educational Resources Information Center

    Toprakci, Erdal

    2012-01-01

    The purpose of this study is to suggest a new perspective and a new horizon by analyzing the concept of classroom management in the literature of traditional classroom management from a scientific and dictionary view. It may be said that there are serious problems regarding the settlement of the meaning of "classroom management" in the educational…

  17. Beyond the Horizon: An Interview with Anishinabe Artist George Morrison.

    ERIC Educational Resources Information Center

    Olbekson, Sam

    1993-01-01

    Anishinabe (Chippewa) artist George Morrison was trained in European art styles and has been influenced by abstract expressionism, surrealism, primitivism, and indigenous art forms. He discusses the recurring horizon line in his works and the relationships between Native and Western artistic styles. (SV)

  18. The Black Hole Horizon as a Dynamical System

    NASA Astrophysics Data System (ADS)

    't Hooft, Gerard

    Interactions between outgoing Hawking particles and ingoing matter are determined by gravitational forces and Standard Model interactions. In particular, the gravitational interactions are responsible for the unitarity of the scattering against the horizon, as dictated by the holographic principle, but the Standard Model interactions also contribute, and understanding their effects is an important first step towards a complete understanding of the horizon's dynamics. The relation between in- and outgoing states is described in terms of an operator algebra. In this contribution, in which earlier results are rederived and elaborated upon, we first describe the algebra induced on the horizon by U(1) vector fields and scalar fields, including the case of an Englert-Brout-Higgs mechanism, and a more careful consideration of the transverse vector field components. We demonstrate that, unlike classical black holes, the quantized black hole has on its horizon an imprint of its (recent) past history, i.e., quantum hair. The relation between in- and outgoing states depends on this imprint. As a first step towards the inclusion of non-Abelian interactions, we then compute the effects of magnetic monopoles both in the in-states and in the out-states. They completely modify, and indeed simplify, our algebra.

  19. How Big Is the Earth? A Calculation beyond Your Horizon

    ERIC Educational Resources Information Center

    Kibble, Bob

    2011-01-01

    A consequence of the curvature of the Earth is that distant ships apparently disappear over the horizon. This article shows how you can use a simple photograph to help students obtain a reasonable estimate of the size of the Earth using little more than the mathematics of Pythagoras. (Contains 5 figures.)

  20. Colorful Horizons with Charge in Anti-de Sitter Space

    SciTech Connect

    Gubser, Steven S.

    2008-11-07

    An Abelian gauge symmetry can be spontaneously broken near a black hole horizon in anti-de Sitter space using a condensate of non-Abelian gauge fields. A second order phase transition is shown to separate Reissner-Nordstroem-anti-de Sitter solutions from a family of symmetry-breaking solutions which preserve a diagonal combination of gauge invariance and spatial rotational invariance.