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Sample records for genome horizons michael

  1. Prioritizing genomic applications for action by level of evidence: a horizon-scanning method.

    PubMed

    Dotson, W D; Douglas, M P; Kolor, K; Stewart, A C; Bowen, M S; Gwinn, M; Wulf, A; Anders, H M; Chang, C Q; Clyne, M; Lam, T K; Schully, S D; Marrone, M; Feero, W G; Khoury, M J

    2014-04-01

    As evidence accumulates on the use of genomic tests and other health-related applications of genomic technologies, decision makers may increasingly seek support in identifying which applications have sufficiently robust evidence to suggest they might be considered for action. As an interim working process to provide such support, we developed a horizon-scanning method that assigns genomic applications to tiers defined by availability of synthesized evidence. We illustrate an application of the method to pharmacogenomics tests.

  2. Exploring Horizons for Domestic Animal Genomics: Workshop Summary

    SciTech Connect

    Board on Agriculture and Natural Resources, Board on Life Sciences, Division on Earth and Life Studies, National Research Council by Robert Pool and Kim Waddell

    2002-09-03

    Recognizing the important contributions that genomics analysis can make to agriculture,production and companion animal science, evolutionary biology and human health with respect to the creation of models for genetic disorders, the National Academies convened a group of individuals to plan a public workshop that would (1) assess these contributions; (2) identify potential research directions for existing genomics programs; and (3) highlight the opportunities of a coordinated, multi-species genomics effort for the science and policymaking communities. Their efforts culminated in a workshop the goal of which was to focus on domestic animal genomics and its integration with other genomics and functional genomics projects. A summary and synthesis of the discussion was produced and is a factual account of what occurred at the workshop.

  3. Genomic and physiological footprint of the Deepwater Horizon oil spill on resident marsh fishes.

    PubMed

    Whitehead, Andrew; Dubansky, Benjamin; Bodinier, Charlotte; Garcia, Tzintzuni I; Miles, Scott; Pilley, Chet; Raghunathan, Vandana; Roach, Jennifer L; Walker, Nan; Walter, Ronald B; Rice, Charles D; Galvez, Fernando

    2012-12-11

    The biological consequences of the Deepwater Horizon oil spill are unknown, especially for resident organisms. Here, we report results from a field study tracking the effects of contaminating oil across space and time in resident killifish during the first 4 mo of the spill event. Remote sensing and analytical chemistry identified exposures, which were linked to effects in fish characterized by genome expression and associated gill immunohistochemistry, despite very low concentrations of hydrocarbons remaining in water and tissues. Divergence in genome expression coincides with contaminating oil and is consistent with genome responses that are predictive of exposure to hydrocarbon-like chemicals and indicative of physiological and reproductive impairment. Oil-contaminated waters are also associated with aberrant protein expression in gill tissues of larval and adult fish. These data suggest that heavily weathered crude oil from the spill imparts significant biological impacts in sensitive Louisiana marshes, some of which remain for over 2 mo following initial exposures.

  4. Single-cell genomics reveals features of a Colwellia species that was dominant during the Deepwater Horizon oil spill

    PubMed Central

    Mason, Olivia U.; Han, James; Woyke, Tanja; Jansson, Janet K.

    2014-01-01

    During the Deepwater Horizon (DWH) oil spill in the Gulf of Mexico a deep-sea hydrocarbon plume developed resulting in a rapid succession of bacteria. Colwellia eventually supplanted Oceanospirillales, which dominated the plume early in the spill. These successional changes may have resulted, in part, from the changing composition and abundance of hydrocarbons over time. Colwellia abundance peaked when gaseous and simple aromatic hydrocarbons increased, yet the metabolic pathway used by Colwellia in hydrocarbon disposition is unknown. Here we used single-cell genomics to gain insights into the genome properties of a Colwellia enriched during the DWH deep-sea plume. A single amplified genome (SAG) of a Colwellia cell isolated from a DWH plume, closely related (avg. 98% 16S rRNA gene similarity) to other plume Colwellia, was sequenced and annotated. The SAG was similar to the sequenced isolate Colwellia psychrerythraea 34H (84% avg. nucleotide identity). Both had genes for denitrification, chemotaxis, and motility, adaptations to cold environments and a suite of nutrient acquisition genes. The Colwellia SAG may be capable of gaseous and aromatic hydrocarbon degradation, which contrasts with a DWH plume Oceanospirillales SAG which encoded non-gaseous n-alkane and cycloalkane degradation pathways. The disparate hydrocarbon degradation pathways are consistent with hydrocarbons that were abundant at different times in the deep-sea plume; first, non-gaseous n-alkanes and cycloalkanes that could be degraded by Oceanospirillales, followed by gaseous, and simple aromatic hydrocarbons that may have been degraded by Colwellia. These insights into the genomic properties of a Colwellia species, which were supported by existing metagenomic sequence data from the plume and DWH contaminated sediments, help further our understanding of the successional changes in the dominant microbial players in the plume over the course of the DWH spill. PMID:25071745

  5. Genomes of Planktonic Acidimicrobiales: Widening Horizons for Marine Actinobacteria by Metagenomics

    PubMed Central

    Mizuno, Carolina Megumi; Ghai, Rohit

    2015-01-01

    ABSTRACT The genomes of four novel marine Actinobacteria have been assembled from large metagenomic data sets derived from the Mediterranean deep chlorophyll maximum (DCM). These are the first marine representatives belonging to the order Acidimicrobiales and only the second group of planktonic marine Actinobacteria to be described. Their streamlined genomes and photoheterotrophic lifestyle suggest that they are planktonic, free-living microbes. A novel rhodopsin clade, acidirhodopsins, related to freshwater actinorhodopsins, was found in these organisms. Their genomes suggest a capacity to assimilate C2 compounds, some using the glyoxylate bypass and others with the ethylmalonyl-coenzyme A (CoA) pathway. They are also able to derive energy from dimethylsulfopropionate (DMSP), sulfonate, and carbon monoxide oxidation, all commonly available in the marine habitat. These organisms appear to be prevalent in the deep photic zone at or around the DCM. The presence of sister clades to the marine Acidimicrobiales in freshwater aquatic habitats provides a new example of marine-freshwater transitions with potential evolutionary insights. PMID:25670777

  6. Following Michael Faraday's Footprints

    NASA Astrophysics Data System (ADS)

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable for following Michael Faraday's footprints. There are many other places in Europe of special interest for the physics teacher,2,3 and some useful guides to help us visit places as "scientific travelers,"4,5 but this paper focuses on Michael Faraday and London. I have personally visited most of the places described below and found the experience to be really worthwhile.

  7. Draft genome sequence of the marine Rhodobacteraceae strain O3.65, cultivated from oil-polluted seawater of the Deepwater Horizon oil spill.

    PubMed

    Giebel, Helge-Ansgar; Klotz, Franziska; Voget, Sonja; Poehlein, Anja; Grosser, Katrin; Teske, Andreas; Brinkhoff, Thorsten

    2016-01-01

    The marine alphaproteobacterium strain O3.65 was isolated from an enrichment culture of surface seawater contaminated with weathered oil (slicks) from the Deepwater Horizon (DWH) oil spill and belongs to the ubiquitous, diverse and ecological relevant Roseobacter group within the Rhodobacteraceae. Here, we present a preliminary set of physiological features of strain O3.65 and a description and annotation of its draft genome sequence. Based on our data we suggest potential ecological roles of the isolate in the degradation of crude oil within the network of the oil-enriched microbial community. The draft genome comprises 4,852,484 bp with 4,591 protein-coding genes and 63 RNA genes. Strain O3.65 utilizes pentoses, hexoses, disaccharides and amino acids as carbon and energy source and is able to grow on several hydroxylated and substituted aromatic compounds. Based on 16S rRNA gene comparison the closest described and validated strain is Phaeobacter inhibens DSM 17395, however, strain O3.65 is lacking several phenotypic and genomic characteristics specific for the genus Phaeobacter. Phylogenomic analyses based on the whole genome support extensive genetic exchange of strain O3.65 with members of the genus Ruegeria, potentially by using the secretion system type IV. Our physiological observations are consistent with the genomic and phylogenomic analyses and support that strain O3.65 is a novel species of a new genus within the Rhodobacteraceae.

  8. Following Michael Faraday's Footprints

    ERIC Educational Resources Information Center

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

  9. Michael Faraday's Bicentenary.

    ERIC Educational Resources Information Center

    Williams, L. Pearce; And Others

    1991-01-01

    Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

  10. Goodbye Michael Gove

    ERIC Educational Resources Information Center

    Bassey, Michael

    2014-01-01

    Michael Gove was Secretary of State for Education from May 2010 to July 2014 when the Prime Minister sacked him. With strong opinions arising from his own life experiences and outstanding energy for reform, but severely limited understanding of education and a refusal to consult teachers and other professionals, he imposed half-baked ideas on the…

  11. Michael Faraday, media man.

    PubMed

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles.

  12. Multi-tissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis)

    PubMed Central

    Dubansky, Benjamin; Whitehead, Andrew; Miller, Jeffrey; Rice, Charles D.; Galvez, Fernando

    2013-01-01

    The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish (Fundulus grandis) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL), and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver and gill tissue coincident with the arrival of contaminating oil, and up-regulation of cytochrome P4501A (CYP1A) protein in gill, liver, intestine and head kidney for over one year following peak landfall of oil (August, 2011) compared to fish collected from reference sites. Furthermore, laboratory exposures of Gulf killifish embryos to field-collected sediments from Grande Terre and Barataria Bay, LA also resulted in increased CYP1A and developmental abnormalities when exposed to sediments collected from oiled sites compared to exposure to sediments collected from a reference site. These data are predictive of population-level impacts in fish exposed to sediments from oiled locations along the Gulf of Mexico coast. PMID:23659337

  13. Multitissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis).

    PubMed

    Dubansky, Benjamin; Whitehead, Andrew; Miller, Jeffrey T; Rice, Charles D; Galvez, Fernando

    2013-05-21

    The Deepwater Horizon oil rig disaster resulted in crude oil contamination along the Gulf coast in sensitive estuaries. Toxicity from exposure to crude oil can affect populations of fish that live or breed in oiled habitats as seen following the Exxon Valdez oil spill. In an ongoing study of the effects of Deepwater Horizon crude oil on fish, Gulf killifish ( Fundulus grandis ) were collected from an oiled site (Grande Terre, LA) and two reference locations (coastal MS and AL) and monitored for measures of exposure to crude oil. Killifish collected from Grande Terre had divergent gene expression in the liver and gill tissue coincident with the arrival of contaminating oil and up-regulation of cytochrome P4501A (CYP1A) protein in gill, liver, intestine, and head kidney for over one year following peak landfall of oil (August 2011) compared to fish collected from reference sites. Furthermore, laboratory exposures of Gulf killifish embryos to field-collected sediments from Grande Terre and Barataria Bay, LA, also resulted in increased CYP1A and developmental abnormalities when exposed to sediments collected from oiled sites compared to exposure to sediments collected from a reference site. These data are predictive of population-level impacts in fish exposed to sediments from oiled locations along the Gulf of Mexico coast.

  14. Enantioselective Michael addition of water.

    PubMed

    Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

    2015-02-09

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry.

  15. Enantioselective Michael Addition of Water

    PubMed Central

    Chen, Bi-Shuang; Resch, Verena; Otten, Linda G; Hanefeld, Ulf

    2015-01-01

    The enantioselective Michael addition using water as both nucleophile and solvent has to date proved beyond the ability of synthetic chemists. Herein, the direct, enantioselective Michael addition of water in water to prepare important β-hydroxy carbonyl compounds using whole cells of Rhodococcus strains is described. Good yields and excellent enantioselectivities were achieved with this method. Deuterium labeling studies demonstrate that a Michael hydratase catalyzes the water addition exclusively with anti-stereochemistry. PMID:25529526

  16. HORIZON SENSING

    SciTech Connect

    Larry G. Stolarczyk

    2003-03-18

    With the aid of a DOE grant (No. DE-FC26-01NT41050), Stolar Research Corporation (Stolar) developed the Horizon Sensor (HS) to distinguish between the different layers of a coal seam. Mounted on mining machine cutter drums, HS units can detect or sense the horizon between the coal seam and the roof and floor rock, providing the opportunity to accurately mine the section of the seam most desired. HS also enables accurate cutting of minimum height if that is the operator's objective. Often when cutting is done out-of-seam, the head-positioning function facilitates a fixed mining height to minimize dilution. With this technology, miners can still be at a remote location, yet cut only the clean coal, resulting in a much more efficient overall process. The objectives of this project were to demonstrate the feasibility of horizon sensing on mining machines and demonstrate that Horizon Sensing can allow coal to be cut cleaner and more efficiently. Stolar's primary goal was to develop the Horizon Sensor (HS) into an enabling technology for full or partial automation or ''agile mining''. This technical innovation (R&D 100 Award Winner) is quickly demonstrating improvements in productivity and miner safety at several prominent coal mines in the United States. In addition, the HS system can enable the cutting of cleaner coal. Stolar has driven the HS program on the philosophy that cutting cleaner coal means burning cleaner coal. The sensor, located inches from the cutting bits, is based upon the physics principles of a Resonant Microstrip Patch Antenna (RMPA). When it is in proximity of the rock-coal interface, the RMPA impedance varies depending on the thickness of uncut coal. The impedance is measured by the computer-controlled electronics and then sent by radio waves to the mining machine. The worker at the machine can read the data via a Graphical User Interface, displaying a color-coded image of the coal being cut, and direct the machine appropriately. The Horizon Sensor

  17. Killing Horizons Kill Horizon Degrees

    NASA Astrophysics Data System (ADS)

    Bergamin, L.; Grumiller, D.

    Frequently, it is argued that the microstates responsible for the Bekenstein-Hawking entropy should arise from some physical degrees of freedom located near or on the black hole horizon. In this essay, we elucidate that instead entropy may emerge from the conversion of physical degrees of freedom, attached to a generic boundary, into unobservable gauge degrees of freedom attached to the horizon. By constructing the reduced phase space, it can be demonstrated that such a transmutation indeed takes place for a large class of black holes, including Schwarzschild.

  18. Genomic and genotoxic responses to controlled weathered-oil exposures confirm and extend field studies on impacts of the Deepwater Horizon oil spill on native killifish.

    PubMed

    Pilcher, Whitney; Miles, Scott; Tang, Song; Mayer, Greg; Whitehead, Andrew

    2014-01-01

    To understand the ecotoxicological impacts of the Deepwater Horizon oil spill, field studies provide a context for ecological realism but laboratory-based studies offer power for connecting biological effects with specific causes. As a complement to field studies, we characterized genome-wide gene expression responses of Gulf killifish (Fundulus grandis) to oil-contaminated waters in controlled laboratory exposures. Transcriptional responses to the highest concentrations of oiled water in the laboratory were predictive of field-observed responses that coincided with the timing and location of major oiling. The transcriptional response to the low concentration (∼ 10-fold lower than the high concentration) was distinct from the high concentration and was not predictive of major oiling in the field. The high concentration response was characterized by activation of the molecular signaling pathway that facilitates oil metabolism and oil toxicity. The high concentration also induced DNA damage. The low concentration invoked expression of genes that may support a compensatory response, including genes associated with regulation of transcription, cell cycle progression, RNA processing, DNA damage, and apoptosis. We conclude that the gene expression response detected in the field was a robust indicator of exposure to the toxic components of contaminating oil, that animals in the field were exposed to relatively high concentrations that are especially damaging to early life stages, and that such exposures can damage DNA.

  19. Genomic and Genotoxic Responses to Controlled Weathered-Oil Exposures Confirm and Extend Field Studies on Impacts of the Deepwater Horizon Oil Spill on Native Killifish

    PubMed Central

    Pilcher, Whitney; Miles, Scott; Tang, Song; Mayer, Greg; Whitehead, Andrew

    2014-01-01

    To understand the ecotoxicological impacts of the Deepwater Horizon oil spill, field studies provide a context for ecological realism but laboratory-based studies offer power for connecting biological effects with specific causes. As a complement to field studies, we characterized genome-wide gene expression responses of Gulf killifish (Fundulus grandis) to oil-contaminated waters in controlled laboratory exposures. Transcriptional responses to the highest concentrations of oiled water in the laboratory were predictive of field-observed responses that coincided with the timing and location of major oiling. The transcriptional response to the low concentration (∼10-fold lower than the high concentration) was distinct from the high concentration and was not predictive of major oiling in the field. The high concentration response was characterized by activation of the molecular signaling pathway that facilitates oil metabolism and oil toxicity. The high concentration also induced DNA damage. The low concentration invoked expression of genes that may support a compensatory response, including genes associated with regulation of transcription, cell cycle progression, RNA processing, DNA damage, and apoptosis. We conclude that the gene expression response detected in the field was a robust indicator of exposure to the toxic components of contaminating oil, that animals in the field were exposed to relatively high concentrations that are especially damaging to early life stages, and that such exposures can damage DNA. PMID:25208076

  20. Michael Beitz: Objects of Communication

    ERIC Educational Resources Information Center

    Hoefferle, Mary

    2014-01-01

    For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

  1. Q&A: Michael Honey

    ERIC Educational Resources Information Center

    Helicher, Karl

    2007-01-01

    The mid-1960s saw civil rights victories in Congress during Lyndon B. Johnson's presidency. In "Going Down Jericho Road," Michael Honey wrote how Martin Luther King Jr.'s final focus showed that the struggle for black and working class parity continued. The 1968 Memphis sanitation workers strike was a gritty struggle won in the streets by a host…

  2. Michael Sadler and Comparative Education

    ERIC Educational Resources Information Center

    Phillips, David

    2006-01-01

    This paper examines the work in education of Michael Sadler (1861-1943). It covers his early years in Oxford, his time as director of the Department of Special Inquiries and Reports, his periods as professor of education in Manchester and as vice-chancellor in Leeds, and his return to Oxford as Master of University College, and it assesses the…

  3. A Conversation with Michael Byram

    ERIC Educational Resources Information Center

    Wagner, Manuela

    2013-01-01

    In language teaching, it has been universally acknowledged that students need not just knowledge and skill in the grammar of a language but also the ability to use the language in socially and culturally appropriate ways. In this article Michael Byram, who has been working on Intercultural Competence for quite some time in a variety of different…

  4. Michael J. Fox: Spurring Research on Parkinson's

    MedlinePlus

    ... turn JavaScript on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past Issues / Winter 2014 Table of Contents Michael J. Fox and his wife, actress Tracy Pollan, founded the ...

  5. Michael Faraday vs. the Spiritualists

    NASA Astrophysics Data System (ADS)

    Hirshfeld, Alan

    2006-12-01

    In the 1850s, renowned physicist Michael Faraday launched a public campaign against pseudoscience and spiritualism, which were rampant in England at the time. Faraday objected especially to claims that electrical or magnetic forces were responsible for paranormal phenomena, such as table-spinning and communication with the dead. Using scientific methods, Faraday unmasked the deceptions of spiritualists, clairvoyants and mediums and also laid bare the credulity of a public ill-educated in science. Despite his efforts, Victorian society's fascination with the paranormal swelled. Faraday's debacle anticipates current controversies about public science education and the interface between science and religion. This episode is one of many described in the new biography, The Electric Life of Michael Faraday (Walker & Co.), which chronicles Faraday's discoveries and his unlikely rise from poverty to the pinnacle of the English science establishment.

  6. Organocatalytic aza-Michael/retro-aza-Michael reaction: pronounced chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction.

    PubMed

    Cai, Yong-Feng; Li, Li; Luo, Meng-Xian; Yang, Ke-Fang; Lai, Guo-Qiao; Jiang, Jian-Xiong; Xu, Li-Wen

    2011-05-01

    A detailed experimental investigation of an aza-Michael reaction of aniline and chalcone is presented. A series of Cinchona alkaloid-derived organocatalysts with different functional groups were prepared and used in the aza-Michael and retro-aza-Michael reaction. There was an interesting finding that a complete reversal of stereoselectivity when a benzoyl group was introduced to the cinchonine and cinchonidine. The chirality amplification vs. time proceeds in the quinine-derived organocatalyst containing silicon-based bulky group, QN-TBS, -catalyzed aza-Michael reaction under solvent-free conditions. In addition, we have demonstrated for the first time that racemization was occurred in suitable solvents under mild conditions due to retro-aza-Michael reaction of the Michael adduct of aniline with chalcone. These indicate the equilibrium of retro-aza-Michael reaction and aza-Michael reaction produce the happening of chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction under different conditions, which would be beneficial to the development of novel chiral catalysts for the aza-Michael reactions.

  7. Michael, Michael-aldol and Michael-Michael reactions of enolate equivalents of butane-2,3-diacetal protected glycolic acid derivatives.

    PubMed

    Ley, Steven V; Dixon, Darren J; Guy, Richard T; Rodríguez, Félix; Sheppard, Tom D

    2005-11-21

    Consecutive coupling reactions of butane-2,3-diacetal protected glycolic acid derivatives with Michael acceptors and aldehydes are reported. An enantiopure sample of this building block was used to kinetically resolve a chiral Michael acceptor present as a racemic mixture of enantiomers.

  8. Jack Michael's Motivation

    ERIC Educational Resources Information Center

    Miguel, Caio F.

    2013-01-01

    Among many of Jack Michael's contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of "motivating operation" (MO) by outlining its development from Skinner's (1938) notion of "drive." Conceptually, Michael's term helped us change our focus on…

  9. Method for promoting Michael addition reactions

    DOEpatents

    Shah, Pankaj V.; Vietti, David E.; Whitman, David William

    2010-09-21

    Homogeneously dispersed solid reaction promoters having an average particle size from 0.01 .mu.m to 500 .mu.m are disclosed for preparing curable mixtures of at least one Michael donor and at least one Michael acceptor. The resulting curable mixtures are useful as coatings, adhesives, sealants and elastomers.

  10. Test pilot Michael R. Swann

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Michael R. Swann joined the National Aeronautics and Space Administration's Dryden Flight Research Center on June 5, 1978, transferring from the NASA's Johnson Space Center, Houston, Texas, as a research pilot. Swann attended North Dakota State University, Fargo, North Dakota, from September 1968 to February 1977, where he earned his Masters in Physics. He was a member of three national honorary scholastic fraternities. Prior to joining NASA Swann served concurrently as an Aerospace Defense Command Interceptor pilot in the Air National Guard for five years and as a college physics instructor at North Dakota State University for two years. While at Johnson Space Center Mike was a pilot on high altitude earth resources and air sampling missions. He was also an instructor and check pilot for the Astronaut Space Flight Readiness Training program. As a Dryden research pilot Mike was involved with the F-111 #778 Transonic Aircraft Technology (TACT) program, F-15 # 281 Shuttle Tile tests, programs on the F-8C #802 and the PA-30 #808 Remotely Piloted Research Vehicle. He flew the Bell 47G #822 helicopter in support of research with the three-eighths-scale F-15 Spin Research Vehicle. On March 28, 1979, Mike made a pilot familiarization flight in the YF-12A #935. He also flew support flights in the F-104, C-47, T-37, T-38, and the Jetstar aircraft. Michael R. Swann was born June 5, 1949, in Fargo, North Dakota; he was fatally injured in a recreational glider accident on July 28, 1981, near California City, California.

  11. Two Horizons of Fusion

    ERIC Educational Resources Information Center

    Lo, Mun Ling; Chik, Pakey Pui Man

    2016-01-01

    In this paper, we aim to differentiate the internal and external horizons of "fusion." "Fusion" in the internal horizon relates to the structure and meaning of the object of learning as experienced by the learner. It clarifies the interrelationships among an object's critical features and aspects. It also illuminates the…

  12. The 2010 Horizon Report

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Smith, R.; Stone, S.

    2010-01-01

    The annual "Horizon Report" describes the continuing work of the New Media Consortium's Horizon Project, a qualitative research project established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, or creative inquiry on college and university campuses within the next five years. The…

  13. Anomaly corrected heterotic horizons

    NASA Astrophysics Data System (ADS)

    Fontanella, A.; Gutowski, J. B.; Papadopoulos, G.

    2016-10-01

    We consider supersymmetric near-horizon geometries in heterotic supergravity up to two loop order in sigma model perturbation theory. We identify the conditions for the horizons to admit enhancement of supersymmetry. We show that solutions which undergo supersymmetry enhancement exhibit an {s}{l}(2,{R}) symmetry, and we describe the geometry of their horizon sections. We also prove a modified Lichnerowicz type theorem, incorporating α' corrections, which relates Killing spinors to zero modes of near-horizon Dirac operators. Furthermore, we demonstrate that there are no AdS2 solutions in heterotic supergravity up to second order in α' for which the fields are smooth and the internal space is smooth and compact without boundary. We investigate a class of nearly supersymmetric horizons, for which the gravitino Killing spinor equation is satisfied on the spatial cross sections but not the dilatino one, and present a description of their geometry.

  14. ASK Talks with Dr. Michael Hecht

    NASA Technical Reports Server (NTRS)

    Hecht, Michael

    2003-01-01

    Michael Hecht has been a member of NASA's Jet Propulsion Laboratory (JPL) staff since 1982. He is currently Project Manager and co-investigator for the Mars Environmental Compatibility Assessment (MECA)

  15. ATV2 Interview with Michael Suffredini

    NASA Video Gallery

    International Space Station Manager Michael Suffredini answers questions about the European Space Agency’s second Automated Transfer Vehicle (ATV2), Johannes Kepler, set to launch from a launch p...

  16. Michael Thackeray on Lithium-air Batteries

    ScienceCinema

    Thackeray, Michael

    2016-07-12

    Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

  17. Parity horizons in shape dynamics

    NASA Astrophysics Data System (ADS)

    Herczeg, Gabriel

    2016-11-01

    I introduce the notion of a parity horizon, and show that many simple solutions of shape dynamics possess them. I show that the event horizons of the known asymptotically flat black hole solutions of shape dynamics are parity horizons and that this notion of parity implies that these horizons possess a notion of CPT invariance that can in some cases be extended to the solution as a whole. I present three new solutions of shape dynamics with parity horizons and find that not only do event horizons become parity horizons in shape dynamics, but observer-dependent horizons and Cauchy horizons do as well. The fact that Cauchy horizons become (singular) parity horizons suggests a general chronology protection mechanism in shape dynamics that prevents the formation of closed timelike curves.

  18. New Horizons at Pluto

    NASA Astrophysics Data System (ADS)

    Schenk, Paul; Nimmo, Francis

    2016-06-01

    The New Horizons mission has revealed Pluto and its moon Charon to be geologically active worlds. The familiar, yet exotic, landforms suggest that geologic processes operate similarly across the Solar System, even in its cold outer reaches.

  19. Investigation of horizon Beta.

    PubMed

    Windisch, C C; Leyden, R J; Worzel, J L; Saito, T; Ewing, J

    1968-12-27

    Horizon beta is a subbottom reflector in the North Atlantic deep ocean sediments that extends over a large portion of the North America basin. Cores from an outcrop of beta contained shallow-water Aptian-Albian sediments and deep-water Cenomanian sediments. A core near an outcrop of a deeper horizon, horizon B, contained shallow-water Lower Cretaceous (Barremian-Hauterivian) sediments. These cores can be interpreted to support extensive subsidence of the eastern portion of the basin in early Cretaceous time. It is equally likely that the shallow-water deposits are a result of sediments slumping into an already deep basin. A reconciliation of these interpretations depends upon the JOIDES project.

  20. Firewall or smooth horizon?

    NASA Astrophysics Data System (ADS)

    Ori, Amos

    2016-01-01

    Almheiri, Marolf, Polchinski, and Sully pointed out that for a sufficiently old black hole (BH), the set of assumptions known as the complementarity postulates appears to be inconsistent with the assumption of local regularity at the horizon. They concluded that the horizon of an old BH is likely to be the locus of local irregularity, a "firewall". Here I point out that if one adopts a different assumption, namely that semiclassical physics holds throughout its anticipated domain of validity, then the inconsistency is avoided, and the horizon retains its regularity. In this alternative view-point, the vast portion of the original BH information remains trapped inside the BH throughout the semiclassical domain of evaporation, and possibly leaks out later on. This appears to be an inevitable outcome of semiclassical gravity (if assumed to apply throughout its anticipated domain of validity).

  1. Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/Michael addition via dynamic kinetic resolution: access to highly functionalized chromans with three contiguous stereocenters.

    PubMed

    Yang, Wen; Yang, Yi; Du, Da-Ming

    2013-03-15

    An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with three contiguous stereocenters, including one quaternary center. In addition, a novel cascade sulfa Michael/retro-sulfa-Michael/sulfa-Michael/Michael reaction process, involving dynamic kinetic resolution, is described.

  2. Novel Cauchy-horizon instability

    SciTech Connect

    Maeda, Hideki; Torii, Takashi; Harada, Tomohiro

    2005-03-15

    The evolution of weak discontinuity is investigated on horizons in the n-dimensional static solutions in the Einstein-Maxwell-scalar-{lambda} system, including the Reissner-Nordstroem-(anti) de Sitter black hole. The analysis is essentially local and nonlinear. We find that the Cauchy horizon is unstable, whereas both the black hole event horizon and the cosmological event horizon are stable. This new instability, the so-called kink instability, of the Cauchy horizon is completely different from the well-known 'infinite-blueshift' instability. The kink instability makes the analytic continuation beyond the Cauchy horizon unstable.

  3. Michael Gorman vs. Web 2.0

    ERIC Educational Resources Information Center

    Chronicle of Higher Education, 2007

    2007-01-01

    In a much-discussed series of postings on the Encyclopaedia Britannica Online Web site, Michael Gorman, former president of the American Library Association and the recently retired dean of library services at California State University at Fresno, argues that the "often-anarchic world of the Internet" is saturating people's culture with a "tide…

  4. Michael J. Moravcsik: A biographical sketch

    NASA Astrophysics Data System (ADS)

    Goldstein, G. R.

    1990-06-01

    A brief biography of Michael J. Moravcsik is presented, concentrating on the chronology of his contributions to theoretical high- and intermediateenergy physics. The evolution of his interest in science development in the third world, scientific methodology, and scientometrics are indicated. A personal reminiscence is included.

  5. Michael Slote and "Sentimentalist Moral Education"

    ERIC Educational Resources Information Center

    Wren, Thomas

    2010-01-01

    Although I think most of what Michael Slote asserts in his article "Sentimentalist moral education" is correct, I worry about three important ideas that are conspicuous by their absence. The first is the possibility that human emotions and feelings are inherently cognitive, which is never considered in his psychological account of empathy. The…

  6. Michael Polanyi 1891-1976: A Rememberance

    ERIC Educational Resources Information Center

    Manno, Bruno V.

    1977-01-01

    Michael Polanyi was on "JHP's" Board of Editors for many years, and his book, "Personal Knowledge", published in 1958, was an important factor in the development of humanistic psychology. This "rememberance" presents an overview of his personal background and the major outlines of his thought. (Editor/RK)

  7. Michael Walzer's Politics, in Theory and Practice

    ERIC Educational Resources Information Center

    Williams, Jeffrey J.

    2012-01-01

    Before all the talk about "public intellectuals," Michael Walzer was one. For 50 years, he has gone back and forth between positions at Princeton and Harvard Universities and then at the Institute for Advanced Study, in Princeton, New Jersey, where he is now emeritus. His writings appear regularly in "Dissent" magazine, which he has co-edited for…

  8. Against Dogma: A Reply to Michael Swan.

    ERIC Educational Resources Information Center

    Widdowson, H. G.

    1985-01-01

    Replies to two articles by Michael Swan entitled "A Critical Look at the Communicative Approach." Argues that Swan presents a distorted version of the communicative approach so as to present his own ideas more effectively and that he fails to offer evidence for his position on the practice of English language teaching. (SED)

  9. Comments on Michael (1993): Establishing Operations

    ERIC Educational Resources Information Center

    Moore, J.

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but…

  10. A Bibliographic Tribute to Jack Michael

    ERIC Educational Resources Information Center

    Esch, Barbara E.; Esch, John W.

    2016-01-01

    "In the late 1950's, Jack Michael, a bright but irritating young psychology instructor, moved from the Universities of Kansas to Houston to Arizona State. Along the way he befriended two nontraditional students, protected them through their Ph.D. programs, and turned them loose on the world: Teodoro Ayllon…and Montrose Wolf…" (Risley,…

  11. Reframing Michael Scott: Exploring Inappropriate Workplace Communication

    ERIC Educational Resources Information Center

    Schaefer, Zachary A.

    2010-01-01

    Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

  12. Michael Driver: A Career Life to Remember

    ERIC Educational Resources Information Center

    Sundby, Dianne; Derr, C. Brooklyn

    2007-01-01

    Purpose: The purpose of this paper is to present a retrospective of the career life of Michael Driver, from the time of his Princeton graduate studies and early faculty years at Purdue University through the over three decades he spent at USC. Design/methodology/approach: The history and development of his theoretical and research interests are…

  13. International Humanitarian Award: Michael G. Wessells

    ERIC Educational Resources Information Center

    American Psychologist, 2009

    2009-01-01

    Michael G. Wessells, recipient of the International Humanitarian Award, is cited for his pioneering and sustained contributions to the protection of children affected by armed conflict and to the development of international guidelines for the provision of community-based, culturally responsive psychosocial support in emergencies. Wessells has…

  14. Solving the Housing Equation: Michael P. Johnson

    ERIC Educational Resources Information Center

    Roach, Ronald

    2005-01-01

    Dr. Michael P. Johnson, an associate professor of management science and urban affairs at the H. John Heinz III School of Public Policy and Management at Carnegie Mellon University in Pittsburgh, is taking management science tools and innovative information technology applications to the housing field. Concerned that organizations that develop and…

  15. Instability of enclosed horizons

    NASA Astrophysics Data System (ADS)

    Kay, Bernard S.

    2015-03-01

    We point out that there are solutions to the scalar wave equation on dimensional Minkowski space with finite energy tails which, if they reflect off a uniformly accelerated mirror due to (say) Dirichlet boundary conditions on it, develop an infinite stress-energy tensor on the mirror's Rindler horizon. We also show that, in the presence of an image mirror in the opposite Rindler wedge, suitable compactly supported arbitrarily small initial data on a suitable initial surface will develop an arbitrarily large stress-energy scalar near where the two horizons cross. Also, while there is a regular Hartle-Hawking-Israel-like state for the quantum theory between these two mirrors, there are coherent states built on it for which there are similar singularities in the expectation value of the renormalized stress-energy tensor. We conjecture that in other situations with analogous enclosed horizons such as a (maximally extended) Schwarzschild black hole in equilibrium in a (stationary spherical) box or the (maximally extended) Schwarzschild-AdS spacetime, there will be similar stress-energy singularities and almost-singularities—leading to instability of the horizons when gravity is switched on and matter and gravity perturbations are allowed for. All this suggests it is incorrect to picture a black hole in equilibrium in a box or a Schwarzschild-AdS black hole as extending beyond the past and future horizons of a single Schwarzschild (/Schwarzschild-AdS) wedge. It would thus provide new evidence for 't Hooft's brick wall model while seeming to invalidate the picture in Maldacena's ` Eternal black holes in AdS'. It would thereby also support the validity of the author's matter-gravity entanglement hypothesis and of the paper ` Brick walls and AdS/CFT' by the author and Ortíz.

  16. Horizon as critical phenomenon

    NASA Astrophysics Data System (ADS)

    Lee, Sung-Sik

    2016-09-01

    We show that renormalization group flow can be viewed as a gradual wave function collapse, where a quantum state associated with the action of field theory evolves toward a final state that describes an IR fixed point. The process of collapse is described by the radial evolution in the dual holographic theory. If the theory is in the same phase as the assumed IR fixed point, the initial state is smoothly projected to the final state. If in a different phase, the initial state undergoes a phase transition which in turn gives rise to a horizon in the bulk geometry. We demonstrate the connection between critical behavior and horizon in an example, by deriving the bulk metrics that emerge in various phases of the U( N ) vector model in the large N limit based on the holographic dual constructed from quantum renormalization group. The gapped phase exhibits a geometry that smoothly ends at a finite proper distance in the radial direction. The geometric distance in the radial direction measures a complexity: the depth of renormalization group transformation that is needed to project the generally entangled UV state to a direct product state in the IR. For gapless states, entanglement persistently spreads out to larger length scales, and the initial state can not be projected to the direct product state. The obstruction to smooth projection at charge neutral point manifests itself as the long throat in the anti-de Sitter space. The Poincare horizon at infinity marks the critical point which exhibits a divergent length scale in the spread of entanglement. For the gapless states with non-zero chemical potential, the bulk space becomes the Lifshitz geometry with the dynamical critical exponent two. The identification of horizon as critical point may provide an explanation for the universality of horizon. We also discuss the structure of the bulk tensor network that emerges from the quantum renormalization group.

  17. Organocatalyzed cascade aza-Michael/Michael addition for the asymmetric construction of highly functionalized spiropyrazolone tetrahydroquinolines.

    PubMed

    Li, Jun-Hua; Du, Da-Ming

    2014-11-01

    An organocatalyzed diastereo- and enantioselective cascade aza-Michael/Michael addition of 2-tosylaminoenones to unsaturated pyrazolones has been developed to afford novel chiral spiropyrazolone tetrahydroquinolines containing three contiguous stereocenters. This cascade reaction proceeded well with 2 mol% chiral bifunctional tertiary amine squaramide catalyst to give the desired products in excellent yields (up to 99%) with excellent diastereoselectivity (up to >25:1 diastereomeric ratio) and high enantioselectivity (up to 91% enantiomeric excess).

  18. Behind the geon horizon

    NASA Astrophysics Data System (ADS)

    Guica, Monica; Ross, Simon F.

    2015-03-01

    We explore the Papadodimas-Raju prescription for reconstructing the region behind the horizon of one-sided black holes in AdS/CFT in the case of the {R}{{P}2} geon—a simple, analytic example of a single-sided, asymptotically AdS3 black hole, which corresponds to a pure CFT state that thermalizes at late times. We show that in this specific example, the mirror operators involved in the reconstruction of the interior have a particularly simple form: the mirror of a single trace operator at late times is just the corresponding single trace operator at early times. We use some explicit examples to explore how changes in the state modify the geometry inside the horizon.

  19. Horizons of cybernetical physics

    NASA Astrophysics Data System (ADS)

    Fradkov, Alexander L.

    2017-03-01

    The subject and main areas of a new research field-cybernetical physics-are discussed. A brief history of cybernetical physics is outlined. The main areas of activity in cybernetical physics are briefly surveyed, such as control of oscillatory and chaotic behaviour, control of resonance and synchronization, control in thermodynamics, control of distributed systems and networks, quantum control. This article is part of the themed issue 'Horizons of cybernetical physics'.

  20. Refraction near the horizon

    NASA Technical Reports Server (NTRS)

    Schaefer, Bradley E.; Liller, William

    1990-01-01

    Variations in astronomical refraction near the horizon are examined. Sunset timings, a sextant mounted on a tripod, and a temperature profile are utilized to derive the variations in refraction data, collected from 7 locations. It is determined that the refraction ranges from 0.234 to 1.678 deg with an rms deviation of 0.16, and it is observed that the variation is larger than previously supposed. Some applications for the variation of refraction value are discussed.

  1. Horizons of cybernetical physics

    PubMed Central

    2017-01-01

    The subject and main areas of a new research field—cybernetical physics—are discussed. A brief history of cybernetical physics is outlined. The main areas of activity in cybernetical physics are briefly surveyed, such as control of oscillatory and chaotic behaviour, control of resonance and synchronization, control in thermodynamics, control of distributed systems and networks, quantum control. This article is part of the themed issue ‘Horizons of cybernetical physics’. PMID:28115620

  2. An Integral Part of the Frederick Community—Michael Dean | Poster

    Cancer.gov

    For more than 30 years, Michael Dean, Ph.D., has been an integral part of the NCI at Frederick community. In addition to studying several different aspects of genomics and cancer research, he has worked with the Werner H. Kirsten Student Intern Program and also volunteered his time with Mission of Mercy, a community-based organization providing free healthcare and free prescription medications to the uninsured and under-insured.

  3. Obituary: Michael William Johnson, 1949-2007

    NASA Astrophysics Data System (ADS)

    Hockey, Thomas

    2007-12-01

    Michael W. Johnson was born on 1 September 1949. He received his B.S. (Physics) from the University of San Francisco in 1971, his M.S. (Physics) from the University of Toledo in 1974, and his Ph.D. (Astrophysics) from the University of Pennsylvania in 1981. His doctoral thesis was entitled, "HEAO A-1 Observations of X ray Emitting Clusters of Galaxies," and he was an author of a 1983 catalog of X-ray emitting clusters. Johnson was on the science faculty at Maryville University, in St. Louis, Missouri, where he lectured on physics and astronomy. He was husband of attorney Delores M. Johnson and had three daughters. Michael Johnson died on 13 April 2007.

  4. Intermolecular Michael reactions: a computational investigation.

    PubMed

    Kwan, Eugene E; Evans, David A

    2010-11-19

    Computational studies have suggested that η(3)-lithium enolates in which the cation is partially bound to both carbon and oxygen may be important reactive intermediates. DFT calculations are used to demonstrate that explicitly solvated acetone enolates are largely O-bound. With this premise in mind, the stereochemical course of intermolecular Michael additions is examined. The results are generally consistent with what is observed experimentally and the model advanced by Heathcock and co-workers.

  5. Michael J. Fox and his Parkinson's disease.

    PubMed

    Kempster, Peter A

    2004-01-01

    Michael J. Fox was a popular and successful film and television comic actor who developed Parkinson's disease at the age of 29 years. His recently published book, Lucky Man, structured around the story of his Parkinson's disease, is an amusing, briskly paced yet introspective memoir that covers the first 40 years of his life. Although quite anecdotal, it contains interesting observations on the preclinical phase of the disorder, evolution of motor fluctuations, and tactics for pharmacological treatment.

  6. A rapid whole genome sequencing and analysis system supporting genomic epidemiology (7th Annual SFAF Meeting, 2012)

    ScienceCinema

    FitzGerald, Michael [Broad Institute

    2016-07-12

    Michael FitzGerald on "A rapid whole genome sequencing and analysis system supporting genomic epidemiology" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  7. A rapid whole genome sequencing and analysis system supporting genomic epidemiology (7th Annual SFAF Meeting, 2012)

    SciTech Connect

    FitzGerald, Michael

    2012-06-01

    Michael FitzGerald on "A rapid whole genome sequencing and analysis system supporting genomic epidemiology" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  8. Obituary: Michael James Ledlow, 1964-2004

    NASA Astrophysics Data System (ADS)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  9. New Horizons at Pluto

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Artist's concept of the New Horizons spacecraft as it approaches Pluto and its largest moon, Charon, in July 2015. The craft's miniature cameras, radio science experiment, ultraviolet and infrared spectrometers and space plasma experiments will characterize the global geology and geomorphology of Pluto and Charon, map their surface compositions and temperatures, and examine Pluto's atmosphere in detail. The spacecraft's most prominent design feature is a nearly 7-foot (2.1-meter) dish antenna, through which it will communicate with Earth from as far as 4.7 billion miles (7.5 billion kilometers) away.

  10. HORIZON SENSING (PROPOSAL NO.51)

    SciTech Connect

    Larry G. Stolarczyk

    2003-07-30

    Real-time horizon sensing on continuous mining (CM) machines is becoming an industry tool. Installation and testing of production-grade Horizon Sensor (HS) systems has been ongoing this quarter at Monterey Coal Company (ExxonMobil), Mountain Coal Company West Elk Mine (Arch), Deserado Mining Company (Blue Mountain Energy), and The Ohio Valley Coal Company (TOVCC). Monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  11. HORIZON SENSING (PROPOSAL NO.51)

    SciTech Connect

    Larry G. Stolarczyk

    2003-07-01

    Real-time horizon sensing on continuous mining machines is becoming an industry tool. Installation and testing of production-grade Horizon Sensor (HS) systems continued this quarter at Monterey Coal Company (ExxonMobil), Mountain Coal Company West Elk Mine (Arch), and Ohio Valley Coal Company (OVC). Monitoring of system function, user experience, and mining benefits is ongoing. All horizon sensor components have finished MSHA (U.S.) and IEC (International) certification.

  12. What Happens at the Horizon?

    NASA Astrophysics Data System (ADS)

    Mathur, Samir D.

    2013-07-01

    The Schwarzschild metric has an apparent singularity at the horizon r = 2M. What really happens there? If physics at the horizon is "normal" laboratory physics, then we run into Hawking's information paradox. If we want nontrivial structure at the horizon, then we need a mechanism to generate this structure that evades the "no hair" conjectures of the past. Further, if we have such structure, then what would be the role of the traditional black hole metric which continues smoothly past the horizon? Recent work has provided an answer to these questions, and in the process revealed a beautiful tie-up between gravity, string theory and thermodynamics.

  13. Transverse deformations of extreme horizons

    NASA Astrophysics Data System (ADS)

    Li, Carmen; Lucietti, James

    2016-04-01

    We consider the inverse problem of determining all extreme black hole solutions to the Einstein equations with a prescribed near-horizon geometry. We investigate this problem by considering infinitesimal deformations of the near-horizon geometry along transverse null geodesics. We show that, up to a gauge transformation, the linearised Einstein equations reduce to an elliptic PDE for the extrinsic curvature of a cross-section of the horizon. We deduce that for a given near-horizon geometry there exists a finite dimensional moduli space of infinitesimal transverse deformations. We then establish a uniqueness theorem for transverse deformations of the extreme Kerr horizon. In particular, we prove that the only smooth axisymmetric transverse deformation of the near-horizon geometry of extreme Kerr, such that cross-sections of the horizon are marginally trapped surfaces, corresponds to that of the extreme Kerr black hole. Furthermore, we determine all smooth and biaxisymmetric transverse deformations of the near-horizon geometry of the five-dimensional extreme Myers-Perry black hole with equal angular momenta. We find a three parameter family of solutions such that cross-sections of the horizon are marginally trapped, which is more general than the known black hole solutions. We discuss the possibility that they correspond to new five-dimensional vacuum black holes.

  14. Stringy horizons II

    NASA Astrophysics Data System (ADS)

    Giveon, Amit; Itzhaki, Nissan; Kutasov, David

    2016-10-01

    We show that the spectrum of normalizable states on a Euclidean SL(2, R)/U(1) black hole exhibits a duality between oscillator states and wound strings. This duality generalizes the identification between a normalizable mode of dilaton gravity on the cigar and a mode of the tachyon with winding number one around the Euclidean time circle, which plays an important role in the FZZ correspondence. It implies that normalizable states on a large Euclidean black hole have support at widely separated scales. In particular, localized states that are extended over the cap of the cigar (the Euclidian analog of the black hole atmosphere) have a component that is localized near the tip of the cigar (the analog of the stretched horizon). As a consequence of this duality, the states exhibit a transition as a function of radial excitation level. From the perspective of a low energy probe, low lying states are naturally thought of as oscillator states in the black hole atmosphere, while at large excitation level they are naturally described as wound strings. As the excitation level increases, the size of the states first decreases and then increases. This behavior is expected to be a general feature of black hole horizons in string theory.

  15. Technologies on the Horizon: Teachers Respond to the Horizon Report

    ERIC Educational Resources Information Center

    Hodges, Charles B.; Prater, Alyssa H.

    2014-01-01

    The purpose of this study was to investigate teachers' beliefs regarding the integration of technologies from the 2011 K-12 edition of the "Horizon Report" into their local, public school contexts. Teachers read the "Horizon Report" and then participated in an asynchronous, threaded discussion focusing on technologies they…

  16. A conversation with Michael Freeman, MD.

    PubMed

    Freeman, M

    1994-12-01

    The Institute for Behavioral Healthcare, a nonprofit organization that serves as an informational resource on issues surrounding the delivery of Behavioral Health Care Services, has been directed by Dr. Michael Freeman since its inception in 1988. In this crucial, unstable period in health care, membership in the Institute and attendance at its sponsored meetings has increased dramatically. Recently, Medical Interface talked with Dr. Freeman about topics of interest to the behavioral health care industry, ranging from any willing provider laws to the benefit itself.

  17. The stereochemical course of intramolecular Michael reactions.

    PubMed

    Kwan, Eugene E; Scheerer, Jonathan R; Evans, David A

    2013-01-04

    We present a general model for understanding the stereochemical course of intramolecular Michael reactions. We show that the addition of β-ketoester enolates to α,β-unsaturated esters and imides bearing adjacent stereocenters (X, Y = H, Me, OR) leads to high levels of asymmetric induction. Reinforcing and nonreinforcing stereochemical relationships are evaluated from the syn and anti reactant diastereomers. On the basis of synthetic, spectroscopic, and computational studies, we propose that the outcomes of these reactions can be rationalized by a dipole-minimized chair transition-state model.

  18. Richard Michael Suzman (1942-2015).

    PubMed

    Kahneman, Daniel

    2016-01-01

    Presents an obituary for Richard Michael Suzman, who died on April 16, 2015. Suzman was trained as a sociologist and anthropologist, but he was attracted to the approaches of demography and economics. He came to know a great deal about diverse fields of science, including health, physiology, psychology, genetics, and economics. He was a scientific leader who was on a quest to develop new transdisciplinary fields and to mobilize the best scientists to work in them. Suzman's passion for transdisciplinary science was fully expressed in his greatest achievement: the famous Health and Retirement Survey (HRS), which he initiated in 1988 and continued to guide and inspire. (PsycINFO Database Record

  19. Resolving Lifshitz Horizons

    SciTech Connect

    Harrison, Sarah; Kachru, Shamit; Wang, Huajia; /Stanford U., ITP /Stanford U., Phys. Dept. /SLAC

    2012-04-24

    Via the AdS/CFT correspondence, ground states of field theories at finite charge density are mapped to extremal black brane solutions. Studies of simple gravity + matter systems in this context have uncovered wide new classes of extremal geometries. The Lifshitz metrics characterizing field theories with non-trivial dynamical critical exponent z {ne} 1 emerge as one common endpoint in doped holographic toy models. However, the Lifshitz horizon exhibits mildly singular behaviour - while curvature invariants are finite, there are diverging tidal forces. Here we show that in some of the simplest contexts where Lifshitz metrics emerge, Einstein-Maxwell-dilaton theories, generic corrections lead to a replacement of the Lifshitz metric, in the deep infrared, by a re-emergent AdS{sub 2} x R{sup 2} geometry. Thus, at least in these cases, the Lifshitz scaling characterizes the physics over a wide range of energy scales, but the mild singularity is cured by quantum or stringy effects.

  20. Telescopic horizon scanning.

    PubMed

    Koenderink, Jan

    2014-12-20

    The problem of "distortionless" viewing with terrestrial telescopic systems (mainly "binoculars") remains problematic. The so called "globe effect" is only partially counteracted in modern designs. Theories addressing the phenomenon have never reached definitive closure. In this paper, we show that exact distortionless viewing with terrestrial telescopic systems is not possible in general, but that it is in principle possible in-very frequent in battle field and marine applications-the case of horizon scanning. However, this involves cylindrical optical elements. For opto-electronic systems, a full solution is more readily feasible. The solution involves a novel interpretation of the relevant constraints and objectives. For final design decisions, it is not necessary to rely on a corpus of psychophysical (or ergonomic) data, although one has to decide whether the instrument is intended as an extension of the eye or as a "pictorial" device.

  1. The Horizon Report. 2006 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2006

    2006-01-01

    This third edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing discussions…

  2. The Horizon Report. 2005 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2005

    2005-01-01

    This second edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series…

  3. The Horizon Report. 2007 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2007

    2007-01-01

    This fourth edition of the New Media Consortium's (NMC) annual "Horizon Report" describes the continuing work of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on ongoing…

  4. The Horizon Report. 2004 Edition

    ERIC Educational Resources Information Center

    New Media Consortium, 2004

    2004-01-01

    This first edition of the New Media Consortium's (NMC) annual "Horizon Report" details findings of the Horizon Project, a research-oriented effort that seeks to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative expression within higher education. Drawing on an ongoing series of interviews…

  5. Michael Faraday and his contribution to anesthesia.

    PubMed

    Bergman, N A

    1992-10-01

    Michael Faraday (1791-1867) was a protégé of Humphry Davy. He became one of Davy's successors as Professor of Chemistry at the Royal Institution of Great Britain. Of Faraday's many brilliant discoveries in chemistry and physics, probably the best remembered today is his work on electromagnetic induction. Faraday's contribution to introduction of anesthesia was his published announcement in 1818 that inhalation of the vapor of ether produced the same effects on mentation and consciousness as the breathing of nitrous oxide. He most likely became familiar with the central nervous system effects of nitrous oxide through his association with Davy, an avid user of the gas. Sulfuric ether was a common, convenient, cheap, and easily available substance, in contrast to nitrous oxide, which required expensive, cumbersome, and probably not widely available apparatus for its production and administration. The capability for inhaling intoxicating vapors eventually became commonly available with the use of ether instead of the gas. The first surgical anesthetics were a consequence of the resulting student "ether frolics." The 1818 announcement on breathing ether vapor was published anonymously; however, notations in Faraday's handwriting in some of his personal books clearly establish Michael Faraday as the author of this brief communication.

  6. 78 FR 70976 - Horizons ETFs Management (USA) LLC and Horizons ETF Trust; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... COMMISSION Horizons ETFs Management (USA) LLC and Horizons ETF Trust; Notice of Application November 21, 2013... Shares. Applicants: Horizons ETFs Management (USA) LLC (``Horizons'') and Horizons ETF Trust (``Trust... Commission, 100 F Street NE., Washington, DC 20549-1090; Applicants: Horizons ETFs Management (USA) LLC,...

  7. Asymptotic symmetries on Killing horizons

    NASA Astrophysics Data System (ADS)

    Koga, Jun-Ichirou

    2001-12-01

    We investigate asymptotic symmetries regularly defined on spherically symmetric Killing horizons in Einstein theory with or without the cosmological constant. These asymptotic symmetries are described by asymptotic Killing vectors, along which the Lie derivatives of perturbed metrics vanish on a Killing horizon. We derive the general form of the asymptotic Killing vectors and find that the group of asymptotic symmetries consists of rigid O(3) rotations of a horizon two-sphere and supertranslations along the null direction on the horizon, which depend arbitrarily on the null coordinate as well as the angular coordinates. By introducing the notion of asymptotic Killing horizons, we also show that local properties of Killing horizons are preserved not only under diffeomorphisms but also under nontrivial transformations generated by the asymptotic symmetry group. Although the asymptotic symmetry group contains the Diff(S1) subgroup, which results from supertranslations dependent only on the null coordinate, it is shown that the Poisson brackets algebra of the conserved charges conjugate to asymptotic Killing vectors does not acquire nontrivial central charges. Finally, by considering extended symmetries, we discuss the fact that unnatural reduction of the symmetry group is necessary in order to obtain the Virasoro algebra with nontrivial central charges, which is not justified when we respect the spherical symmetry of Killing horizons.

  8. Michael Faraday's Contributions to Archaeological Chemistry.

    PubMed

    Moshenska, Gabriel

    2015-08-01

    The analysis of ancient artefacts is a long but largely neglected thread within the histories of archaeology and chemistry. This paper examines Michael Faraday's contributions to this nascent field, drawing on his published correspondence and the works of his antiquarian collaborators, and focusing in particular on his analyses of Romano-British and ancient Egyptian artefacts. Faraday examined the materials used in ancient Egyptian mummification, and provided the first proof of the use of lead glazes on Roman ceramics. Beginning with an assessment of Faraday's personal interests and early work on antiquities with Humphry Davy, this paper critically examines the historiography of archaeological chemistry and attempts to place Faraday's work within its institutional, intellectual, and economic contexts.

  9. Michael Maier--nine newly discovered letters.

    PubMed

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  10. STS-109 Crew Interviews: Michael J. Massimino

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-109 Mission Specialist Michael J. Massimino is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, and his most memorable experiences. He gives details on the mission's goals and objectives, which focus on the refurbishing of the Hubble Space Telescope, and his role in the mission. He explains the plans for the rendezvous of the Columbia Orbiter with the Hubble Space Telescope. He provides details and timelines for each of the planned Extravehicular Activities (EVAs), which include replacing the solar arrays, changing the Power Control Unit, installing the Advanced Camera for Surveys (ACS), and installing a new Cryocooler for the Near Infrared Camera and Multi-Object Spectrometer (NICMOS). He also describes the break-out plan in place for these spacewalks. The interview ends with Massimino explaining the details of a late addition to the mission's tasks, which is to replace a reaction wheel on the Hubble Space Telescope.

  11. Comments on Michael (1993): establishing operations.

    PubMed

    Moore, J

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but they do so differently. The former does so by discontinuing the response-reinforcer relation. The latter does so by altering the motivation to respond. We emphasize that we shouldn't conclude we have extinguished a response just because we have performed some operation that results in decreased responding. The difference is especially important for an understanding of how we might reduce maladaptive avoidance responses, such as found in phobias or obsessive-compulsive disorders.

  12. Near-horizon Kerr magnetosphere

    NASA Astrophysics Data System (ADS)

    Gralla, Samuel E.; Lupsasca, Alexandru; Strominger, Andrew

    2016-05-01

    We exploit the near-horizon conformal symmetry of rapidly spinning black holes to determine universal properties of their magnetospheres. Analytic expressions are derived for the limiting form of the magnetosphere in the near-horizon region. The symmetry is shown to imply that the black hole Meissner effect holds for free Maxwell fields but is generically violated for force-free fields. We further show that in the extremal limit, near-horizon plasma particles are infinitely boosted relative to accretion flow. Active galactic nuclei powered by rapidly spinning black holes are therefore natural sites for high-energy particle collisions.

  13. Interview with Michael Apple: The Biography of a Public Intellectual

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2015-01-01

    Michael W. Apple is the John Bascom Professor of Curriculum and Instruction and Educational Policy Studies in the Departments of Curriculum and Instruction (CI) and Educational Policy Studies (EPS) at the University of Wisconsin-Madison School of Education where he has taught since 1970. Michael Apple is one of the foremost educational theorists…

  14. Doing It All: Michael Sullivan--Weeks Public Library, NH

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Michael Sullivan is a juggler--not a metaphorical one, a real one. He's also a library director, storyteller, competitive chess player, poet, speaker, and former children's librarian who continues to work with the kids in his community. This article summarizes the accomplishments and work of Michael Sullivan.

  15. Michael J. Meaney: Award for Distinguished Scientific Contributions

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…

  16. Language and Intercultural Education: An Interview with Michael Byram

    ERIC Educational Resources Information Center

    Porto, Melina

    2013-01-01

    This article reports an interview with Michael Byram, Professor Emeritus, University of Durham in the United Kingdom, during his visit to Argentina in September 2011. Michael Byram is one of the main international referents in intercultural education. The interview addresses issues such as language education, intercultural and citizenship…

  17. Michael Naranjo, The Story of an American Indian.

    ERIC Educational Resources Information Center

    Nelson, Mary Carroll

    Michael Naranjo is a Pueblo Indian who, after much searching, has become a talented sculptor. The son of a Baptist minister, Michael grew up observing nature and exploring the countryside around Santa Clara (New Mexico), his birthplace. When he was nine, his family moved to Taos, where he watched the ceremonies of the Taos Pueblos with…

  18. 76 FR 10352 - Keyser, Michael J.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Keyser, Michael J.; Notice of Filing Take notice that on February 15, 2011, Michael J. Keyser submitted for filing, an application for authority to hold interlocking...

  19. Michael Young and the Curriculum Field in South Africa

    ERIC Educational Resources Information Center

    Hoadley, Ursula

    2015-01-01

    The paper addresses the question of what we should make of Michael Young's recent work with respect to curriculum theory by considering the particular case of South African curriculum reform. The paper thus traces two trajectories: the evolution of Michael Young's ideas over time and South African curriculum reform in the post-apartheid period.…

  20. Social Pharmacology: Expanding horizons

    PubMed Central

    Maiti, Rituparna; Alloza, José Luis

    2014-01-01

    In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of “social pharmacology” is not covered by the so-called “Phase IV” alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the “life cycle” of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far-reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of therapy, while minimizing negative social consequences. PMID:24987168

  1. Social pharmacology: expanding horizons.

    PubMed

    Maiti, Rituparna; Alloza, José Luis

    2014-01-01

    In the current modern and global society, social changes are in constant evolution due to scientific progress (technology, culture, customs, and hygiene) and produce the freedom in individuals to take decisions by themselves or with their doctors toward drug consumption. In the arena of marketed drug products which includes society, individual, administration, and pharmaceutical industry, the young discipline emerged is social pharmacology or sociopharmacology. This science arises from clinical pharmacology, and deals with different parameters, which are important in creating knowledge on marketed drugs. However, the scope of "social pharmacology" is not covered by the so-called "Phase IV" alone, but it is the science that handles the postmarketing knowledge of drugs. The social pharmacology studies the "life cycle" of any marketed pharmaceutical product in the social terrain, and evaluates the effects of the real environment under circumstances totally different in the drug development process. Therefore, there are far-reaching horizons, plural, and shared predictions among health professionals and other, for beneficial use of a drug, toward maximizing the benefits of therapy, while minimizing negative social consequences.

  2. Metal-Catalyzed Asymmetric Michael Addition in Natural Product Synthesis.

    PubMed

    Hui, Chunngai; Pu, Fan; Xu, Jing

    2016-12-19

    Asymmetric catalysis for chiral compound synthesis is a rapidly growing field in modern organic chemistry. Asymmetric catalytic processes have been indispensable for the synthesis of enantioselective materials to meet demands from various fields. Michael addition has been used extensively for the construction of C-C bonds under mild conditions. With the discovery and development of organo- and metal-catalyzed asymmetric Michael additions, the synthesis of enantioselective and/or diastereoselective Michael adducts has become possible and increasingly prevalent in the literature. In particular, metal-catalyzed asymmetric Michael addition has been employed as a key reaction in natural product synthesis for the construction of contiguous quaternary stereogenic center(s), which is still a difficult task in organic synthesis. Previously reported applications of metal-catalyzed asymmetric Michael additions in natural product synthesis are presented here and discussed in depth.

  3. Obituary: Michael John Klein, 1940-2005

    NASA Astrophysics Data System (ADS)

    Gulkis, Samuel

    2006-12-01

    Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

  4. Race, punishment, and the Michael Vick experience.

    PubMed

    Piquero, Alex R; Piquero, Nicole Leeper; Gertz, Marc; Baker, Thomas; Batton, Jason; Barnes, J C

    2011-01-01

    Objective. The relationship between race and crime has been contentious, focusing primarily on offending and incarceration patterns among minorities. There has been some limited work on public perceptions of criminal punishment, and findings show that while minorities believe in the role and rule of law, they simultaneously perceive the justice system as acting in a biased and/or unfair manner. Two limitations have stalled this literature. First, research has focused mainly on criminal punishments to the neglect of noncriminal punishments. Second, most studies have not examined whether race remains salient after considering other demographic variables or discrimination and legitimacy attitudes.Methods. Using data from 400 adults, we examine how race affects perceptions of criminal punishment and subsequent reinstatement into the National Football League in the case of Michael Vick, a star professional quarterback who pled guilty to charges of operating an illegal dog-fighting ring.Results. Findings show that whites are more likely to view Vick's punishment as too soft and that he should not be reinstated, while nonwhites had the opposite views. Race remained significant after controlling for other variables believed to be related to punishment perceptions.Conclusion. Attitudes toward both criminal punishment and NFL reinstatement vary across race such that there exists important divides in how individuals perceive the system meting out punishment and subsequently reintegrating offenders back into society. These results underscore that white and nonwhites perceive the law and its administration differently.

  5. The promise of personalized medicine: a conversation with Michael Svinte. Interview by Michael Millenson.

    PubMed

    Svinte, Michael

    2006-01-01

    In early 2004, IBM combined its Healthcare unit, which focused on the technology needs of providers, with its Life Sciences unit, which catered to research scientists. Out of that union was born an "emerging business opportunity" called information-based medicine, in which IBM has already invested tens of millions in the expectation of reaping billions of dollars in revenues. Michael Svinte describes his mission as providing the information technology infrastructure that will enable technologies such as proteomics and molecular imaging to progress from the bench to the bedside, thereby resulting in predictive and personalized health care.

  6. Michael Akam and the rise of evolutionary developmental biology.

    PubMed

    Stern, David L; Dawes-Hoang, Rachel E

    2010-01-01

    Michael Akam has been awarded the 2007 Kowalevsky medal for his many research accomplishments in the area of evolutionary developmental biology. We highlight three tributaries of Michaels contribution to evolutionary developmental biology. First, he has made major contributions to our understanding of development of the fruit fly, Drosophila melanogaster. Second, he has maintained a consistent focus on several key problems in evolutionary developmental biology, including the evolving role of Hox genes in arthropods and, more recently, the evolution of segmentation mechanisms. Third, Michael has written a series of influential reviews that have integrated progress in developmental biology into an evolutionary perspective. Michael has also made a large impact on the field through his effective mentorship style, his selfless promotion of younger colleagues, and his leadership of the University Museum of Zoology at Cambridge and the European community of evolutionary developmental biologists.

  7. Michael López-Alegría Profile

    NASA Video Gallery

    Meet NASA astronaut Michael López-Alegría, a veteran of four spaceflights. He has logged over 257 days in space and performed 10 spacewalks. Learn what inspired him to become such a successful astr...

  8. Satellite Sees Hurricane Leslie and Tropical Storm Michael in Atlantic

    NASA Video Gallery

    A movie of satellite observations from Sept. 2-5, 2012, shows Leslie strengthen into a Hurricane on September 5 as it nears Bermuda, and tiny Tropical Storm Michael in the central Atlantic Ocean. T...

  9. Meet EPA Scientist Michael Nye, Ph.D.

    EPA Pesticide Factsheets

    Michael Nye, Ph.D., is a social scientist who studies natural risk, socio-demographic change and sustainable behavior. Prior to joining EPA, he worked for the UK Environment Agency in flood risk management and emergency preparedness

  10. Michael Polanyi: Science as Personal Knowledge and Social Practice.

    PubMed

    Nye, Mary Jo

    2017-03-20

    Tacit knowing: 2016 marked the 125th anniversary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his death. This essay discusses his philosophy of science-in particular, his most significant work in this area, Personal Knowledge-from the perspective of his personal biography, as well as its lasting influence on the social sciences. In the photograph: Michael Polanyi at the Fritz Haber Institute in 1968.

  11. Deepwater Horizon Situation Report #5

    SciTech Connect

    2010-06-10

    At approximately 11:00 pm EDT April 20, 2010 an explosion occurred aboard the Deepwater Horizon mobile offshore drilling unit (MODU) located 52 miles Southeast of Venice, LA and 130 miles southeast of New Orleans, LA. The MODU was drilling an exploratory well and was not producing oil at the time of the incident. The Deepwater Horizon MODU sank 1,500 feet northwest of the well site. Detailed information on response and recovery operations can be found at: http://www.deepwaterhorizonresponse.com/go/site/2931/

  12. Sodium tetramethoxyborate: an efficient catalyst for Michael additions of stabilized carbon nucleophiles.

    PubMed

    Campaña, Araceli G; Fuentes, Noelia; Gómez-Bengoa, Enrique; Mateo, Cristina; Oltra, J Enrique; Echavarren, Antonio M; Cuerva, Juan M

    2007-10-12

    Sodium tetramethoxyborate, easily prepared by reaction of inexpensive sodium borohydride with methanol, possesses a suitable combination of a Lewis base and a Lewis acid to catalyze Michael reactions at room temperature under practically neutral conditions. This reaction provides good to excellent yields of Michael addition products from a broad scope of Michael donor and Michael acceptor reagents.

  13. NIF featured on BBC "Horizon"

    ScienceCinema

    Brian Cox

    2016-07-12

    The National Ignition Facility, the world's largest laser system, located at Lawrence Livermore National Laboratory, was featured in the BBC broadcast "Horizon" hosted by physicist Brian Cox. Here is the NIF portion of the program, which was entitled "Can We Make A Star On Earth?" This video is used with the express permission of the BBC.

  14. New Horizons Mission to Pluto

    NASA Technical Reports Server (NTRS)

    Delgado, Luis G.

    2011-01-01

    This slide presentation reviews the trajectory that will take the New Horizons Mission to Pluto. Included are photographs of the spacecraft, the launch vehicle, the assembled vehicle as it is being moved to the launch pad and the launch. Also shown are diagrams of the assembled parts with identifying part names.

  15. New Horizons in Education, 2000.

    ERIC Educational Resources Information Center

    Ho, Kwok Keung, Ed.

    2000-01-01

    This document contains the May and November 2000 issues of "New Horizons in Education," with articles in English and Chinese. The May issue includes the following articles: "A Key to Successful Environmental Education: Teacher Trainees' Attitude, Behaviour, and Knowledge" (Kevin Chung Wai Lui, Eric Po Keung Tsang, Sing Lai…

  16. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  17. The Malcolm horizon: History and future

    NASA Technical Reports Server (NTRS)

    Malcolm, R.

    1984-01-01

    The development of the Malcolm Horizon, a peripheral vision horizon used in flight simulation, is discussed. A history of the horizon display is presented as well as a brief overview of vision physiology, and the role balance plays is spatial orientation. Avenues of continued research in subconscious cockpit instrumentation are examined.

  18. Penrose inequality and apparent horizons

    SciTech Connect

    Ben-Dov, Ishai

    2004-12-15

    A spherically symmetric spacetime is presented with an initial data set that is asymptotically flat, satisfies the dominant energy condition, and such that on this initial data M<{radical}(A/16{pi}), where M is the total mass and A is the area of the apparent horizon. This provides a counterexample to a commonly stated version of the Penrose inequality, though it does not contradict the true Penrose inequality.

  19. Toroidal horizons in binary black hole mergers

    NASA Astrophysics Data System (ADS)

    Bohn, Andy; Kidder, Lawrence E.; Teukolsky, Saul A.

    2016-09-01

    We find the first binary black hole event horizon with a toroidal topology. It has been predicted that generically the event horizons of merging black holes should briefly have a toroidal topology. However, such a phase has never been seen in numerical simulations. Instead, in all previous simulations, the topology of the event horizon transitions directly from two spheres during the inspiral to a single sphere as the black holes merge. We find a coordinate transformation to a foliation of spacelike hypersurfaces that "cut a hole" through the event horizon surface, resulting in a toroidal event horizon, thus reconciling the numerical work with theoretical expectations. The demonstration requires extremely high numerical precision, which is made possible by a new event horizon code described in a companion paper. A torus could potentially provide a mechanism for violating topological censorship. However, these toroidal event horizons satisfy topological censorship by construction, because we can always trivially apply the inverse coordinate transformation to remove the topological feature.

  20. Lipase-catalyzed aza-Michael reaction on acrylate derivatives.

    PubMed

    Steunenberg, Peter; Sijm, Maarten; Zuilhof, Han; Sanders, Johan P M; Scott, Elinor L; Franssen, Maurice C R

    2013-04-19

    A methodology has been developed for an efficient and selective lipase-catalyzed aza-Michael reaction of various amines (primary and secondary) with a series of acrylates and alkylacrylates. Reaction parameters were tuned, and under the optimal conditions it was found that Pseudomonas stutzeri lipase and Chromobacterium viscosum lipase showed the highest selectivity for the aza-Michael addition to substituted alkyl acrylates. For the first time also, some CLEAs were examined that showed a comparable or higher selectivity and yield than the free enzymes and other formulations.

  1. Michael hydratase alcohol dehydrogenase or just alcohol dehydrogenase?

    PubMed Central

    2014-01-01

    The Michael hydratase – alcohol dehydrogenase (MhyADH) from Alicycliphilus denitrificans was previously identified as a bi-functional enzyme performing a hydration of α,β-unsaturated ketones and subsequent oxidation of the formed alcohols. The investigations of the bi-functionality were based on a spectrophotometric assay and an activity staining in a native gel of the dehydrogenase. New insights in the recently discovered organocatalytic Michael addition of water led to the conclusion that the previously performed experiments to identify MhyADH as a bi-functional enzyme and their results need to be reconsidered and the reliability of the methodology used needs to be critically evaluated. PMID:24949265

  2. New Horizons Launch Contingency Effort

    NASA Astrophysics Data System (ADS)

    Chang, Yale; Lear, Matthew H.; McGrath, Brian E.; Heyler, Gene A.; Takashima, Naruhisa; Owings, W. Donald

    2007-01-01

    On 19 January 2006 at 2:00 PM EST, the NASA New Horizons spacecraft (SC) was launched from the Cape Canaveral Air Force Station (CCAFS), FL, onboard an Atlas V 551/Centaur/STAR™ 48B launch vehicle (LV) on a mission to explore the Pluto Charon planetary system and possibly other Kuiper Belt Objects. It carried a single Radioisotope Thermoelectric Generator (RTG). As part of the joint NASA/US Department of Energy (DOE) safety effort, contingency plans were prepared to address the unlikely events of launch accidents leading to a near-pad impact, a suborbital reentry, an orbital reentry, or a heliocentric orbit. As the implementing organization. The Johns Hopkins University Applied Physics Laboratory (JHU/APL) had expanded roles in the New Horizons launch contingency effort over those for the Cassini mission and Mars Exploration Rovers missions. The expanded tasks included participation in the Radiological Control Center (RADCC) at the Kennedy Space Center (KSC), preparation of contingency plans, coordination of space tracking assets, improved aerodynamics characterization of the RTG's 18 General Purpose Heat Source (GPHS) modules, and development of spacecraft and RTG reentry breakup analysis tools. Other JHU/APL tasks were prediction of the Earth impact footprints (ElFs) for the GPHS modules released during the atmospheric reentry (for purposes of notification and recovery), prediction of the time of SC reentry from a potential orbital decay, pre-launch dissemination of ballistic coefficients of various possible reentry configurations, and launch support of an Emergency Operations Center (EOC) on the JHU/APL campus. For the New Horizons launch, JHU/APL personnel at the RADCC and at the EOC were ready to implement any real-time launch contingency activities. A successful New Horizons launch and interplanetary injection precluded any further contingency actions. The New Horizons launch contingency was an interagency effort by several organizations. This paper

  3. Obituary: Michael John Seaton, 1923-2007

    NASA Astrophysics Data System (ADS)

    Pradhan, Anil; Nahar, Sultana

    2007-12-01

    Professor Michael John Seaton, hailed as the "Father of Atomic Astrophysics," passed away on May 29, 2007. He was one of the few Honorary Fellows of both the American Astronomical Society and the American Physical Society, so honored for his monumental contributions to both physics and astronomy. Mike Seaton was born on January 16, 1923 in Bristol, England. He attended Wallington County High School. But his leftist political activities, even at that stage, led to his expulsion, though he was eventually allowed to matriculate. He enlisted in the Royal Air Force as a navigator during the Second World War, and flew many dangerous missions. His legendary concentration and precision are reflected in the following anecdote. Once after a bombing mission his aircraft was lost in fog over the Alps. Seaton calculated the position and coordinates in flight to guide the aircraft. When the fog lifted, the crew found themselves flying perilously close to the mountains, but made it safely back. His associates often said, "A Seaton calculation is carried out as if his life depended on it." After the War he was admitted to University College London (UCL) as an undergraduate. Thereafter, he spent all of his professional career at UCL. Seaton received his Batchelor's degree in 1948, and his Ph.D. in 1951. His tenure at UCL coincided with the golden age of atomic astrophysics, for he was largely responsible for it. Seaton was elected Fellow of the Royal Society in 1967, and as President of the Royal Astronomical Society (RAS) in 1978. He was the recipient of an Honorary Doctorate from the Observatoire de Paris, an Honorary D.Sc. from the Queen's University of Belfast, the Gold Medal for Astronomy by the RAS, the Guthrie Medal by the Institute of Physics, the Royal Society Hughes award for lifetime work by the RAS, and several other prestigious awards. Nevertheless, as Alex Dalgarno recently remarked, Seaton was not part of the establishment because he chose not to be. Though rooted in

  4. Squaramide-catalysed asymmetric cascade aza-Michael/Michael addition reaction for the synthesis of chiral trisubstituted pyrrolidines.

    PubMed

    Zhao, Bo-Liang; Lin, Ye; Yan, Hao-Hao; Du, Da-Ming

    2015-12-14

    A bifunctional squaramide catalysed aza-Michael/Michael cascade reaction between nitroalkenes and tosylaminomethyl enones or enoates has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chiral pyrrolidines with a broad substrate scope, giving the desired products in good yields (up to 99%) with good diastereoselectivities (up to 91 : 9 dr) and excellent enantioselectivities (up to >99% ee) under mild conditions. This protocol provides a straightforward entry to highly functionalized chiral trisubstituted pyrrolidine derivatives from simple starting materials.

  5. Reading Michael Apple--The Sociological Imagination at Work

    ERIC Educational Resources Information Center

    Ball, Stephen J.

    2007-01-01

    This article discusses Michael Apple's contribution to the sociology of education and education policy analysis and the politics of education. It focuses on ways of "reading" Apple as an intellectual and an activist and looks at the trajectory of his work over a long and illustrious career.

  6. The origins of Michael Conrad's research programs (1964-1979).

    PubMed

    Pattee, H H

    2002-01-01

    This paper summarizes Michael Conrad's academic and professional career from the time he began his Ph.D. studies in 1964 to his appointment at Wayne State University in 1979. It describes the origins of several of his major research interests and presents a personal evaluation of how this early work continues to be of fundamental importance.

  7. Meet EPA Ecologist Michael Murrell, Ph.D.

    EPA Pesticide Factsheets

    Michael Murrel, Ph.D., is a EPA research ecologist working on the Gulf of Mexico Hypoxia Project, helping develop models of the northern Gulf to quantify the links between freshwater flowing into the Gulf from the land, nutrients, and hypoxia—“dead zones”

  8. Insight into the Mechanism of the Michael Reaction.

    PubMed

    Giraldo, Carolina; Gómez, Sara; Weinhold, Frank; Restrepo, Albeiro

    2016-07-04

    The mechanism for the nucleophilic addition step of the Michael reaction between methanethiol as a model Michael donor and several α-substituted methyl acrylates (X=F, Cl, Me, H, CN, NO2 ) as model Michael acceptors is described in detail. We suggest a novel way to condense electrophilic Fukui functions at specific atoms in terms of the contributions from the atomic orbitals to the LUMO or, more generally, to the orbital controlling the reaction. This procedure correctly associates activation energies to local electrophilic Fukui indices for the cases treated in this work. The calculated reaction barriers strongly depend on the nature of the substituent. As a general rule, activation energies are governed by structural changes, although electronic factors are significant for electron-withdrawing groups. Nucleophilic addition to Michael receptors is best described as a highly nonsynchronous process, in which the geometry of the transition state comprises a nonplanar six-membered ring. Formation of the S⋅⋅⋅C bond, which defines the interaction between the reactants, progresses ahead of all other primitive processes in the early stages of the transformation. In view of our results, we postulate that highly complex chemical reactions, as is the case for the nucleophilic addition step studied herein, that involve cleavage/formation of a total of six bonds, lower their activation energies by favoring nonsynchronicity, that is, for these types of systems, primitive changes should advance at different rates.

  9. Perfil de Michael López- Alegría

    NASA Video Gallery

    Conoce al astronauta de la NASA Michael López-Alegría, veterano de cuatro vuelos espaciales. Lleva registrados 257 días en el espacio y llevó a cabo 10 paseos espaciales. Conoce lo que lo inspiró a...

  10. Michael Polanyi on the Education and Knowledge of Scientists.

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2000-01-01

    Explains why teachers addressing the nature of science should know the work of Michael Polanyi. Outlines Polanyi's intellectual career and examines his ideas on the education of scientists, research, and knowledge. Polanyi presaged Kuhn, Feyerabend, and the constructivists, yet insisted that science produces true knowledge about reality. (Contains…

  11. Michael Polanyi: The University and the Technological State.

    ERIC Educational Resources Information Center

    Price, G. L.

    1978-01-01

    The problem of the intellectual independence of the university within a technologically oriented society was one of the problems which motivated Michael Polanyi's inquiry into the foundations of knowledge. The key elements of his resultant attempt to supersede objectivist accounts of science are isolated, and evaluated. (Editor/RK)

  12. Writing before the Letter: Reading Michael Ondaatje's "Handwriting"

    ERIC Educational Resources Information Center

    Festino, Cielo G.

    2006-01-01

    The purpose of this paper is to offer a reading of "Handwriting", the book of poems by the Canadian-Sri Lankan author, Michael Ondaatje, in which he recovers the recent and ancient cultural history of the island through his reading of different types of scripts and languages. The texts that Ondaatje rewrites in his poems are visual,…

  13. Michael Scott: An Individual and the International System

    ERIC Educational Resources Information Center

    Reardon, Betty

    1971-01-01

    This article describes the efforts of Michael Scott in trying to gain dignity and justice for victims of political violence. It indicates that, though limited, there are still nonviolent recourses open to those who will not use the war system. (Author/JB)

  14. An interview with Michael Fordham. Interview by Paul Roazen.

    PubMed

    Fordham, Michael

    2005-02-01

    In the course of early interviews on the history of psychoanalysis, I saw Michael Fordham in the late summer of 1965. We concentrated primarily on the differences between Freud and Jung, as well as the characteristic distinctions between the two schools that they founded. Fordham also talked about some of his personal contacts with Jung.

  15. Michael Anagnostopoulos: Father of the Kindergarten for the Blind

    ERIC Educational Resources Information Center

    Kondellas, Bill

    2004-01-01

    Early childhood instruction and the experiences that accompany can serve life-long lessons. Depriving children of education during this critical period in life can have significant consequences on cognitive, socio-emotional, and physical development. This article features one of the forerunners to special education, Michael Anagnostopoulos…

  16. Michael Young's "The Rise of the Meritocracy": A Philosophical Critique

    ERIC Educational Resources Information Center

    Allen, Ansgar

    2011-01-01

    This paper examines Michael Young's 1958 dystopia, "The Rise of the Meritocracy". In this book, the word "meritocracy" was coined and used in a pejorative sense. Today, however, meritocracy represents a positive ideal against which we measure the justice of our institutions. This paper argues that, when read in the twenty-first century, Young's…

  17. The Epistemic Criterion: A Response to Michael Hand

    ERIC Educational Resources Information Center

    Cooling, Trevor

    2014-01-01

    This article is a response to Michael Hand's critique in this issue of my response to his use of the epistemic criterion as the sole means for identifying whether or not an issue should be identified as controversial. I argue that he has misunderstood my intention in suggesting that I was seeking to replace the epistemic criterion. Rather my…

  18. HEADSTONES OF BERNARD AND MICHAEL JODD, FATHERANDSON CIVILIANS RESPONSIBLE FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HEADSTONES OF BERNARD AND MICHAEL JODD, FATHER-AND-SON CIVILIANS RESPONSIBLE FOR CONSTRUCTION OF BRICK PERIMETER WALL WHO DIED OF YELLOW FEVER DURING WALL CONSTRUCTION. VIEW TO WEST. - Baton Rouge National Cemetery, 220 North 19th Street, Baton Rouge, East Baton Rouge Parish, LA

  19. Major Michael J. Colburn: A Passion for Music Shapes Lives

    ERIC Educational Resources Information Center

    Colburn, Michael J.

    2004-01-01

    This article is adapted from a speech given by Major Michael J. Colburn executive officer and senior assistant director of the United States Marine Band, to the MENC Summer Leadership Conference July 12-15, 2003 at the MENC national headquarters in Reston, Virginia. In this article, Colburn shares three personal anecdotes that he considers to be…

  20. A Good Time: A Conversation with C. Michael Nelson

    ERIC Educational Resources Information Center

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  1. Michael Young and the Politics of the School Curriculum

    ERIC Educational Resources Information Center

    Morgan, John

    2015-01-01

    Michael Young's work is central to debates about knowledge and the school curriculum. In recent years he has renounced his early argument that school subjects represent the "knowledge of the powerful", arguing instead that access and equality for all students are dependent on ensuring that all get access to "powerful…

  2. Goodwill Ambassador: Michael Neubert--Library of Congress, Washington, DC

    ERIC Educational Resources Information Center

    Library Journal, 2004

    2004-01-01

    This article details the work of Michael Neubert from the Library of Congress. It briefly discusses his interest in Russian studies and how it originated. It then discusses that when he received his M.A. in Soviet Studies he was not sure how he would make a living--until he read about the job opportunities for area studies librarians.

  3. Shaping the Global Civil Society: An Interview with Michael Peters

    ERIC Educational Resources Information Center

    Heraud, Richard; Tesar, Marek

    2017-01-01

    Professor Michael A. Peters has worked in an era of transformation that has taken him from a labour-intensive paper-based form of production to the computerised reproduction of thought, and the current shift in the publishing landscape from a reader-subscription to an author-pays model. Most of what he has learned in publishing and editing he has…

  4. Genres and Genre Theory: A Response to Michael Rosen

    ERIC Educational Resources Information Center

    Christie, Frances

    2013-01-01

    This paper responds to Michael Rosen's blog entries, "How Genre Theory Saved the World", arguing that genre theory in the tradition of systemic functional linguistics (SFL) has made an important contribution to language and literacy pedagogy. It emerged in the Australian context in about 1980 and was initially developed in response to…

  5. What Works, Works Everywhere: Q&A with Michael Barber

    ERIC Educational Resources Information Center

    Crow, Tracy

    2009-01-01

    This article presents an interview with Michael Barber, a partner at McKinsey & Company, leading its global education practice. He has been working on major challenges of performance, organization, and reform in government and the public services, especially education, in the U.S., U.K., and other countries. Barber was instrumental in preparing…

  6. Michael Stipe Wake-Up Song and Greeting

    NASA Video Gallery

    The four astronauts of the final space shuttle mission are greeted by R.E.M. front man Michael Stipe and the group’s hit, "Man on the Moon" to begin Flight Day 7. On recording this song for the A...

  7. On Happiness and High Achievement: An Interview with Michael Thompson

    ERIC Educational Resources Information Center

    National Association of Independent Schools (NAIS) (NJ), 2006

    2006-01-01

    Michael G. Thompson knows independent schools. He attended them in elementary and secondary school, and has worked in them as a psychologist. He consults with more than 30 schools a year, addressing a myriad of issues related to complex human interaction. He has written often in "Independent School" about everything from understanding the social…

  8. Proof Positive: Q&A with Michael Fullan

    ERIC Educational Resources Information Center

    Crow, Tracy

    2009-01-01

    This article presents an interview with Michael Fullan, an internationally recognized expert in educational change. A prolific writer and speaker, Fullan has worked in schools and educational systems around the world, including his home province of Ontario, Canada. He partners with a variety of projects designed to engineer school improvement and…

  9. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  10. Michael Young, Knowledge and Curriculum: An International Dialogue

    ERIC Educational Resources Information Center

    Deng, Zongyi

    2015-01-01

    This issue of the "Journal of Curriculum Studies" presents a symposium on the recent work of Michael Young. Contemporary curriculum theory has little specific to say about how knowledge is selected, organized and transformed into curriculum content for teaching and learning. Over the last two decades, Young has taken a rather different…

  11. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    ERIC Educational Resources Information Center

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  12. Expert system for predicting reaction conditions: the Michael reaction case.

    PubMed

    Marcou, G; Aires de Sousa, J; Latino, D A R S; de Luca, A; Horvath, D; Rietsch, V; Varnek, A

    2015-02-23

    A generic chemical transformation may often be achieved under various synthetic conditions. However, for any specific reagents, only one or a few among the reported synthetic protocols may be successful. For example, Michael β-addition reactions may proceed under different choices of solvent (e.g., hydrophobic, aprotic polar, protic) and catalyst (e.g., Brønsted acid, Lewis acid, Lewis base, etc.). Chemoinformatics methods could be efficiently used to establish a relationship between the reagent structures and the required reaction conditions, which would allow synthetic chemists to waste less time and resources in trying out various protocols in search for the appropriate one. In order to address this problem, a number of 2-classes classification models have been built on a set of 198 Michael reactions retrieved from literature. Trained models discriminate between processes that are compatible and respectively processes not feasible under a specific reaction condition option (feasible or not with a Lewis acid catalyst, feasible or not in hydrophobic solvent, etc.). Eight distinct models were built to decide the compatibility of a Michael addition process with each considered reaction condition option, while a ninth model was aimed to predict whether the assumed Michael addition is feasible at all. Different machine-learning methods (Support Vector Machine, Naive Bayes, and Random Forest) in combination with different types of descriptors (ISIDA fragments issued from Condensed Graphs of Reactions, MOLMAP, Electronic Effect Descriptors, and Chemistry Development Kit computed descriptors) have been used. Models have good predictive performance in 3-fold cross-validation done three times: balanced accuracy varies from 0.7 to 1. Developed models are available for the users at http://infochim.u-strasbg.fr/webserv/VSEngine.html . Eventually, these were challenged to predict feasibility conditions for ∼50 novel Michael reactions from the eNovalys database (originally

  13. Horizon dynamics of distorted rotating black holes

    SciTech Connect

    Chu, Tony; Cohen, Michael I.; Pfeiffer, Harald P.

    2011-05-15

    We present numerical simulations of a rotating black hole distorted by a pulse of ingoing gravitational radiation. For strong pulses, we find up to five concentric marginally outer trapped surfaces. These trapped surfaces appear and disappear in pairs, so that the total number of such surfaces at any given time is odd. The world tubes traced out by the marginally outer trapped surfaces are found to be spacelike during the highly dynamical regime, approaching a null hypersurface at early and late times. We analyze the structure of these marginally trapped tubes in the context of the dynamical horizon formalism, computing the expansion of outgoing and incoming null geodesics, as well as evaluating the dynamical horizon flux law and the angular momentum flux law. Finally, we compute the event horizon. The event horizon is well-behaved and approaches the apparent horizon before and after the highly dynamical regime. No new generators enter the event horizon during the simulation.

  14. Variable horizon in a peridynamic medium

    DOE PAGES

    Silling, Stewart A.; Littlewood, David J.; Seleson, Pablo

    2015-12-10

    Here, a notion of material homogeneity is proposed for peridynamic bodies with variable horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties unchanged. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under a homogeneous deformation. These artifacts depend on the second derivative of the horizon and can be reduced by employing a modified equilibrium equation using a new quantity called the partial stress. Bodies with piecewise constant horizon can be modeled without ghost forcesmore » by using a simpler technique called a splice. As a limiting case of zero horizon, both the partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.« less

  15. Variable horizon in a peridynamic medium

    SciTech Connect

    Silling, Stewart A.; Littlewood, David J.; Seleson, Pablo

    2015-12-10

    Here, a notion of material homogeneity is proposed for peridynamic bodies with variable horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties unchanged. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under a homogeneous deformation. These artifacts depend on the second derivative of the horizon and can be reduced by employing a modified equilibrium equation using a new quantity called the partial stress. Bodies with piecewise constant horizon can be modeled without ghost forces by using a simpler technique called a splice. As a limiting case of zero horizon, both the partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.

  16. Variable horizon in a peridynamic medium.

    SciTech Connect

    Silling, Stewart Andrew; Littlewood, David John; Seleson, Pablo

    2014-10-01

    A notion of material homogeneity is proposed for peridynamic bodies with vari- able horizon but constant bulk properties. A relation is derived that scales the force state according to the position-dependent horizon while keeping the bulk properties un- changed. Using this scaling relation, if the horizon depends on position, artifacts called ghost forces may arise in a body under homogeneous deformation. These artifacts de- pend on the second derivative of horizon and can be reduced by use of a modified equilibrium equation using a new quantity called the partial stress . Bodies with piece- wise constant horizon can be modeled without ghost forces by using a technique called a splice between the regions. As a limiting case of zero horizon, both partial stress and splice techniques can be used to achieve local-nonlocal coupling. Computational examples, including dynamic fracture in a one-dimensional model with local-nonlocal coupling, illustrate the methods.

  17. Dr. Michael DeBakey "is a magician of the heart…"

    MedlinePlus

    ... NLM's David Nash and admiring students from the Michael E. DeBakey High School for Health Professionals in Houston, ... pump to assist a patient's damaged heart. Dr. Michael E. DeBakey, shown with his surgical team in the ...

  18. 78 FR 69661 - Michael Canales v. Edison International, EIX, Southern California Edison; Notice of Complaint

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... Energy Regulatory Commission Michael Canales v. Edison International, EIX, Southern California Edison....1, Michael Canales (Complainant) filed a formal complaint against Edison International, EIX and Southern California Edison (collectively, Respondents), alleging that the Respondents' actions, as...

  19. Theory underlying the peripheral vision horizon device

    NASA Technical Reports Server (NTRS)

    Money, K. E.

    1984-01-01

    Peripheral Vision Horizon Device (PVHD) theory states that the likelihood of pilot disorientation in flight is reduced by providing an artificial horizon that provides orientation information to peripheral vision. In considering the validity of the theory, three areas are explored: the use of an artificial horizon device over some other flight instrument; the use of peripheral vision over foveal vision; and the evidence that peripheral vision is well suited to the processing of orientation information.

  20. Domino Michael-Michael and Aldol-Aldol Reactions: Diastereoselective Synthesis of Functionalized Cyclohexanone Derivatives Containing Quaternary Carbon Center.

    PubMed

    Ghorai, Manas K; Halder, Sandipan; Das, Subhomoy

    2015-10-02

    A simple strategy for the synthesis of highly functionalized cyclohexanone derivatives containing an all-carbon quaternary center from α-(aryl/alkyl)methylidene-β-keto esters or β-diketones via a K-enolate mediated domino Michael-Michael reaction sequence with moderate to good yield and excellent diastereoselectivity (de > 99%) is described. Interestingly, Li-base mediated reaction of α-arylmethylidene-β-diketones affords functionalized 3,5-dihydroxy cyclohexane derivatives as the kinetically controlled products via a domino aldol-aldol reaction sequence with excellent diastereoselectivity. Li-enolates of the β-keto esters or β-diketones undergo facile domino Michael-Michael reaction with nitro-olefins to afford the corresponding nitrocyclohexane derivatives in good yields and excellent diastereoselectivity (de > 99%). The formation of the products and the observed stereoselectivity were explained by plausible mechanisms and supported by extensive computational study. An asymmetric version of the protocol was explored with (L)-menthol derived nonracemic substrates, and the corresponding nonracemic cyclohexanone derivatives containing an all-carbon quaternary center were obtained with excellent stereoselectivity (de, ee > 99%).

  1. Noncommutativity in near horizon symmetries in gravity

    NASA Astrophysics Data System (ADS)

    Majhi, Bibhas Ranjan

    2017-02-01

    We have a new observation that near horizon symmetry generators, corresponding to diffeomorphisms which leave the horizon structure invariant, satisfy noncommutative Heisenberg algebra. The results are valid for any null surfaces (which have Rindler structure in the near null surface limit) and in any spacetime dimensions. Using the Sugawara construction technique the central charge is identified. It is shown that the horizon entropy is consistent with the standard form of the Cardy formula. Therefore we feel that the noncommutative algebra might lead to quantum mechanics of horizon and also can probe into the microscopic description of entropy.

  2. Smooth horizons and quantum ripples

    NASA Astrophysics Data System (ADS)

    Golovnev, Alexey

    2015-05-01

    Black holes are unique objects which allow for meaningful theoretical studies of strong gravity and even quantum gravity effects. An infalling and a distant observer would have very different views on the structure of the world. However, a careful analysis has shown that it entails no genuine contradictions for physics, and the paradigm of observer complementarity has been coined. Recently this picture was put into doubt. In particular, it was argued that in old black holes a firewall must form in order to protect the basic principles of quantum mechanics. This AMPS paradox has already been discussed in a vast number of papers with different attitudes and conclusions. Here we want to argue that a possible source of confusion is the neglect of quantum gravity effects. Contrary to widespread perception, it does not necessarily mean that effective field theory is inapplicable in rather smooth neighbourhoods of large black hole horizons. The real offender might be an attempt to consistently use it over the huge distances from the near-horizon zone of old black holes to the early radiation. We give simple estimates to support this viewpoint and show how the Page time and (somewhat more speculative) scrambling time do appear.

  3. Organocatalytic asymmetric Michael addition of 1-acetylcyclohexene and 1-acetylcyclopentene to nitroolefins.

    PubMed

    Nath, Utpal; Banerjee, Ankush; Ghosh, Bidhan; Pan, Subhas Chandra

    2015-07-07

    Enantioselective organocatalytic Michael addition reactions of 1-acetylcyclohexene, 1-acetylcyclopentene and 1-acetylcyclobutene to nitroolefins have been developed. This is the first report where an α-branched enone has been activated by an amine catalyst for the asymmetric Michael addition reaction to an electrophile. The Michael products have also been cyclized to bicyclic compounds.

  4. 76 FR 55904 - Michael J. Donahue; Notice of Termination of Exemption By Implied Surrender and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... Energy Regulatory Commission Michael J. Donahue; Notice of Termination of Exemption By Implied Surrender...: Michael J. Donahue. e. Name and Location of Project: The Fairbanks Mill Project is located on the Sleeper... Information: Mr. Michael J. Donahue, Route 3, Box 269, Lincoln, NH 03251. h. FERC Contact: Tom Papsidero,...

  5. 76 FR 58264 - Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... Energy Regulatory Commission Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender...: Michael J. Donahue. e. Name and Location of Project: The Fairbanks Mill Project is located on the Sleeper... Information: Mr. Michael J. Donahue, Route 3, Box 269, Lincoln, NH 03251. h. FERC Contact: Tom Papsidero,...

  6. Clouds Move Across Mars Horizon

    NASA Technical Reports Server (NTRS)

    2008-01-01

    This sequence combines 32 images of clouds moving eastward across a Martian horizon. The Surface Stereo Imager on NASA's Phoenix Mars Lander took this set of images on Sept. 18, 2008, during early afternoon hours of the 113th Martian day of the mission.

    The view is toward the north. The actual elapsed time between the first image and the last image is nearly half an hour. The numbers inset at lower left are the elapsed time, in seconds, after the first image of the sequence. The particles in the clouds are water-ice, as in cirrus clouds on Earth.

    Phoenix landed in the northern region of Mars on May 25, 2008. The mission is led by the University of Arizona, Tucson, on behalf of NASA. Project management of the mission is led by NASA's Jet Propulsion Laboratory, Pasadena, Calif. Spacecraft development was by Lockheed Martin Space Systems, Denver.

  7. The NMC Horizon Report: 2014 Library Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2014-01-01

    The internationally recognized "NMC Horizon Report" series and regional "NMC Technology Outlooks" are part of the NMC Horizon Project, a 12-year effort established in 2002 that annually identifies and describes emerging technologies likely to have a large impact over the coming five years in every sector of education around the…

  8. Horizon Report: 2009 Economic Development Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Scott, C.; Smith, R.; Stone, S.

    2009-01-01

    The New Media Consortium's Horizon Project is an ongoing research project that seeks to identify and describe emerging technologies likely to have a large impact in education and other industries around the world over a five-year time period. The chief products of the project are the "Horizon Reports", an annual series of publications…

  9. The NMC Horizon Report: 2015 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming years on a variety of sectors around the globe. This "2015 Horizon…

  10. The Horizon Report: 2010 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Witchey, H.; Smith, R.; Levine, A.; Haywood, K.

    2010-01-01

    The internationally recognized series of "Horizon Reports" is part of the New Media Consortium's Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years on a variety of sectors around the globe. This volume, the "2010 Horizon…

  11. Expanding your horizons in science and mathematics

    NASA Technical Reports Server (NTRS)

    Palmer, Cynthia E. A.

    1995-01-01

    The purpose of the 'Expanding Your Horizons in Science and Mathematics' program is to interest young women in grades six through twelve in a variety of careers where mathematics and science are important. Progress in encouraging young women to take courses in mathematics, science, and technological subjects is discussed. Also included are adult, student, and organizational information packets used for 'Expanding Your Horizons' conferences.

  12. Michael Kasha: from photochemistry and flowers to spectroscopy and music.

    PubMed

    Demchenko, Alexander P; Heldt, Józef; Waluk, Jacek; Chou, Pi-Tai; Sengupta, Pradeep K; Brizhik, Larissa; del Valle, Juan Carlos

    2014-12-22

    A brilliant scientist and an outstanding personality who was one of the founders of modern photochemistry-Michael Kasha-is the subject of this Essay. Kasha's rule and the Kasha effect both bear his name, and he also discovered the chemical production of singlet molecular oxygen, and was a pioneer of excited-state proton transfer systems. Kasha combined his passion for chemistry and physics with that for music, photography, and botany.

  13. Phosphine-boronates: efficient bifunctional organocatalysts for Michael addition.

    PubMed

    Baslé, Olivier; Porcel, Susana; Ladeira, Sonia; Bouhadir, Ghenwa; Bourissou, Didier

    2012-05-11

    Phosphine-boronates R(2)P(o-C(6)H(4))B(OR')(2) have been evaluated as bifunctional organocatalysts for the Michael addition of malonate pronucleophiles to methylvinylketone. The presence of the Lewis acidic boron center adjacent to phosphorus significantly improves catalytic performance. Isolation and complete characterization of a key intermediate, namely a β-phosphonium enolate, substantiate the role of the Lewis acidic moiety in the catalytic process.

  14. A novel look at the Michael lattice sum rules

    NASA Astrophysics Data System (ADS)

    Rothe, Heinz J.

    1995-02-01

    We reconsider the derivation of the Michael lattice sum rules, which relate the energy and action stored in a flux tube of a quark-antiquark pair to the static interquark potential, and show that they require essential corrections. We then find, using the coupling constant sum rule of Karsch, that the total Minkowski field energy does not match the interquark potential, if one follows conventional notions. The implications of this result are discussed.

  15. Analysis of the black crust on Saint Michael's Church

    NASA Astrophysics Data System (ADS)

    Popister, I.; Zeman, A.

    2012-04-01

    The goal of the present study is to characterize the black crust on the main stone used at Saint Michael's Church in Cluj-Napoca, Romania. The gases in the atmosphere, along with natural and artificial pollutants can cause damage the integrity of the stone when it comes in contact with the stone's chemistry. In order to explain the mechanism of stone decay due to black crust it is necessary to know what "weathering" means, so it must be seen as a complex process that consists of: type of material, the environment in which the material is located, and the amount of time required for the process to take place. Each material has particular properties, due to its composition and genesis. When it comes in contact with the acidity of the "acid rain" (caused by sulphur, nitrogen oxides and carbon dioxide), the rain penetrates into the pore structure, corroding it and "allowing" the atmospheric particles to penetrate the stone. St. Michael's Church is one of the oldest Gothic architectural monuments in Cluj, Romania, being built predominantly from Cenozoic (Upper Eocene) limestone, locally known as the Cluj Limestone. The main quarry was in Baciu, near Cluj. The samples that were collected from the Saint Michael's Church were characterized by means of: optical microscope, Scattering Electronic Microscope, thin sections, EDS The samples that were collected from the Saint Michael's Church went through a series of tests: optical microscope, Scattering Electronic Microscope, thin sections, EDX, and cross-section. The optical microscope analysis of the thin sections revealed that the black crust layer is approximately 0.01mm, and in the sample there are perfectly shaped ooides, which is characteristic to this type of limestone. The SEM analysis shows a resedimentation layer on the surface of the black crust, which occurred probably due to the effect of acid rain. Further information regarding the results of the test will be presented on the poster.

  16. Chandra Uncovers New Evidence For Event Horizons Surrounding Black Holes

    NASA Astrophysics Data System (ADS)

    2001-01-01

    SAN DIEGO -- Astronomers have used NASA's Chandra X-ray Observatory to study some of the darkest black holes yet observed. Their work strongly confirms the reality of the "event horizon," the one-way membrane around black holes predicted by Einstein's theory of relativity. The findings were presented today at the American Astronomical Society meeting by Drs. Michael Garcia, Jeffrey McClintock, Ramesh Narayan, and Stephen Murray of the Harvard-Smithsonian Center for Astrophysics and Dr. Paul Callanan of University College, Cork, Ireland. With results that fundamentally differ from earlier black hole studies, Garcia and his colleagues have shown that some recently discovered black holes are not only ultra-dense, but actually possess event horizons that "vacuum up" energy from their surroundings. "It is a bit odd to say we've discovered something by seeing almost nothing at all -- less than the smile of the Cheshire cat, so to speak," said Garcia, lead author on a paper submitted to the Astrophysical Journal, "but, in essence, this is what we have done." Using data from Chandra and previous X-ray satellites like ROSAT, the Chandra team studied a dozen "X-ray novas," so named because they occasionally erupt as brilliant X-ray sources then settle into decades of dormancy. The great outpouring of X rays is due to a stream of gas that is pulled from the surface of a Sun-like companion star onto a compact object, either a black hole or a neutron star. By comparing the energy output from the dormant X-ray novas, the team discovered that the sources with black holes emitted only one percent as much energy while dormant as did the X-ray novae with neutron stars. "The most straightforward explanation of these observations is that the black hole candidates we have studied have event horizons that swallow just about all of the energy that surrounds them," said Murray. "Indeed, one could even say that this work shows why black holes deserve to be called ‘black.’" "The event

  17. Quasilocal approach to general universal horizons

    NASA Astrophysics Data System (ADS)

    Maciel, Alan

    2016-05-01

    Theories of gravity with a preferred foliation usually display arbitrarily fast signal propagation, changing the black hole definition. A new inescapable barrier, the universal horizon, has been defined and many static and spherically symmetric examples have been studied in the literature. Here, we translate the usual definition of the universal horizon in terms of an optical scalar built with the preferred flow defined by the preferred spacetime foliation. The new expression has the advantages of being of quasilocal nature and independent of specific spacetime symmetries in order to be well defined. Therefore, we propose it as a definition for general quasilocal universal horizons. Using the new formalism, we show that there is no universal analog of cosmological horizons for Friedmann-Lemaître-Robertson-Walker models for any scale factor function, and we also state that quasilocal universal horizons are restricted to trapped regions of the spacetime. Using the evolution equation, we analyze the formation of universal horizons under a truncated Hořava-Lifshitz theory, in spherical symmetry, showing the existence of regions in parameter space where the universal horizon formation cannot be smooth from the center, under some physically reasonable assumptions. We conclude with our view on the next steps for the understanding of black holes in nonrelativistic gravity theories.

  18. Inner and outer horizons of time experience.

    PubMed

    Wackermann, Jirí

    2007-05-01

    Human experience of temporal durations exhibits a multi-regional structure, with more or less distinct boundaries, or horizons, on the scale of physical duration. The inner horizons are imposed by perceptual thresholds for simultaneity (approximately equal to 3 ms) and temporal order (approximatly equal to 30 ms), and are determined by the dynamical properties of the neural substrate integrating sensory information. Related to the inner horizon of experienced time are perceptual or cognitive "moments." Comparative data on autokinetic times suggest that these moments may be relatively invariant (approximately equal to 10(2) ms) across a wide range of species. Extension of the "sensible present" (approximately equal to 3 s) defines an intermediate horizon, beyond which the generic experience of duration develops. The domain of immediate duration experience is delimited by the ultimate outer horizon at about = 10(2) s, as evidenced by analysis of duration reproduction experiments (reproducibility horizon), probably determined by relaxation times of "neural accumulators." Beyond these phenomenal horizons, time is merely cognitively (re)constructed, not actually experienced or "perceived," a fact that is frequently ignored by contemporary time perception research. The nyocentric organization of time experience shows an interesting analogy with the egocentric organization of space, suggesting that structures of subjective space and time are derived from active motion as a common experiential basis.

  19. Production and decay of evolving horizons

    NASA Astrophysics Data System (ADS)

    Nielsen, Alex B.; Visser, Matt

    2006-07-01

    We consider a simple physical model for an evolving horizon that is strongly interacting with its environment, exchanging arbitrarily large quantities of matter with its environment in the form of both infalling material and outgoing Hawking radiation. We permit fluxes of both lightlike and timelike particles to cross the horizon, and ask how the horizon grows and shrinks in response to such flows. We place a premium on providing a clear and straightforward exposition with simple formulae. To be able to handle such a highly dynamical situation in a simple manner we make one significant physical restriction—that of spherical symmetry—and two technical mathematical restrictions: (1) we choose to slice the spacetime in such a way that the spacetime foliations (and hence the horizons) are always spherically symmetric. (2) Furthermore, we adopt Painlevé Gullstrand coordinates (which are well suited to the problem because they are nonsingular at the horizon) in order to simplify the relevant calculations. Of course physics results are ultimately independent of the choice of coordinates, but this particular coordinate system yields a clean physical interpretation of the relevant physics. We find particularly simple forms for surface gravity, and for the first and second law of black hole thermodynamics, in this general evolving horizon situation. Furthermore, we relate our results to Hawking's apparent horizon, Ashtekar and co-worker's isolated and dynamical horizons, and Hayward's trapping horizon. The evolving black hole model discussed here will be of interest, both from an astrophysical viewpoint in terms of discussing growing black holes and from a purely theoretical viewpoint in discussing black hole evaporation via Hawking radiation.

  20. Friedmann equations and thermodynamics of apparent horizons.

    PubMed

    Gong, Yungui; Wang, Anzhong

    2007-11-23

    With the help of a masslike function which has a dimension of energy and is equal to the Misner-Sharp mass at the apparent horizon, we show that the first law of thermodynamics of the apparent horizon dE=T(A)dS(A) can be derived from the Friedmann equation in various theories of gravity, including the Einstein, Lovelock, nonlinear, and scalar-tensor theories. This result strongly suggests that the relationship between the first law of thermodynamics of the apparent horizon and the Friedmann equation is not just a simple coincidence, but rather a more profound physical connection.

  1. NEW HORIZONS IN SENSOR DEVELOPMENT

    PubMed Central

    Intille, Stephen S.; Lester, Jonathan; Sallis, James F.; Duncan, Glen

    2011-01-01

    Background Accelerometery and other sensing technologies are important tools for physical activity measurement. Engineering advances have allowed developers to transform clunky, uncomfortable, and conspicuous monitors into relatively small, ergonomic, and convenient research tools. New devices can be used to collect data on overall physical activity and in some cases posture, physiological state, and location, for many days or weeks from subjects during their everyday lives. In this review article, we identify emerging trends in several types of monitoring technologies and gaps in the current state of knowledge. Best practices The only certainty about the future of activity sensing technologies is that researchers must anticipate and plan for change. We propose a set of best practices that may accelerate adoption of new devices and increase the likelihood that data being collected and used today will be compatible with new datasets and methods likely to appear on the horizon. Future directions We describe several technology-driven trends, ranging from continued miniaturization of devices that provide gross summary information about activity levels and energy expenditure, to new devices that provide highly detailed information about the specific type, amount, and location of physical activity. Some devices will take advantage of consumer technologies, such as mobile phones, to detect and respond to physical activity in real time, creating new opportunities in measurement, remote compliance monitoring, data-driven discovery, and intervention. PMID:22157771

  2. Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors

    PubMed Central

    Men, Ruizhi; Li, Ning; Ding, Chihong; Tang, Yingzhan; Xing, Yachao; Ding, Wanjing; Ma, Zhongjun

    2016-01-01

    Background: The fruits of some varieties of genus Physalis have been used as delicious fruits and functional food in the Northeast of China. Materials and Methods: To reveal the functional material basis, we performed bioactivity-guided phytochemical research and chemopreventive effect assay of the constituents from Physalis minima. Results: It was demonstrated that the ethyl acetate extract of P. minima L. (EEPM) had potential quinone reductase (QR) inducing activity with induction ratio (IR, QR induction activity) value of 1.47 ± 0.24, and glutathione binding property as potential Michael reaction acceptors (with an α, β-unsaturated ketone moiety). Furthermore, bioactivity-guided phytochemical research led eight compounds (1–8), which were elucidated as 3-isopropyl-5-acetoxycyclohexene-2-one-1 (1), isophysalin B (2), physalin G (3), physalin D (4), physalin I (5), physordinose B (6), stigmasterol-3-O-β-D-glucopyranoside (7) and 5α-6β-dihydroxyphysalin R (8) on the basis of nuclear magnetic resonance spectroscopy analyses and HRESIMS. Then, isophysalin B (2) and physordinose B (6) showed significant QR inducing activity with IR value of 2.80 ± 0.19 and 2.38 ± 0.46, respectively. SUMMARY An ultra-performance liquid chromatographic method with glutathione as the substrate was used to detect the Michael reaction acceptors in extracts of Physalis minima (EPM)We investigated the chemical constituents of EPM guided by biological activity methodIsophysalin B (1) and physordinose B (6) showed strong quinone reductase inducing activity with induction ratio values of 2.80 ± 0.19 and 2.38 ± 0.46This study generated useful information for consumers and many encourage researchers to utilize edible fruits from Physalis as a source of phytochemicals Abbreviations used: EPM: Extracts of Physalis minima, EEPM: Ethyl acetate extract of Physalis minima L., GSH: Glutathione, MRAs: Michael reaction acceptors, QR: Quinone reductase. PMID:27279713

  3. Nonlinear optics of fibre event horizons.

    PubMed

    Webb, Karen E; Erkintalo, Miro; Xu, Yiqing; Broderick, Neil G R; Dudley, John M; Genty, Goëry; Murdoch, Stuart G

    2014-09-17

    The nonlinear interaction of light in an optical fibre can mimic the physics at an event horizon. This analogue arises when a weak probe wave is unable to pass through an intense soliton, despite propagating at a different velocity. To date, these dynamics have been described in the time domain in terms of a soliton-induced refractive index barrier that modifies the velocity of the probe. Here we complete the physical description of fibre-optic event horizons by presenting a full frequency-domain description in terms of cascaded four-wave mixing between discrete single-frequency fields, and experimentally demonstrate signature frequency shifts using continuous wave lasers. Our description is confirmed by the remarkable agreement with experiments performed in the continuum limit, reached using ultrafast lasers. We anticipate that clarifying the description of fibre event horizons will significantly impact on the description of horizon dynamics and soliton interactions in photonics and other systems.

  4. Horizon Entropy from Quantum Gravity Condensates.

    PubMed

    Oriti, Daniele; Pranzetti, Daniele; Sindoni, Lorenzo

    2016-05-27

    We construct condensate states encoding the continuum spherically symmetric quantum geometry of a horizon in full quantum gravity, i.e., without any classical symmetry reduction, in the group field theory formalism. Tracing over the bulk degrees of freedom, we show how the resulting reduced density matrix manifestly exhibits a holographic behavior. We derive a complete orthonormal basis of eigenstates for the reduced density matrix of the horizon and use it to compute the horizon entanglement entropy. By imposing consistency with the horizon boundary conditions and semiclassical thermodynamical properties, we recover the Bekenstein-Hawking entropy formula for any value of the Immirzi parameter. Our analysis supports the equivalence between the von Neumann (entanglement) entropy interpretation and the Boltzmann (statistical) one.

  5. Substrate-controlled Michael additions of chiral ketones to enones.

    PubMed

    Fàbregas, Mireia; Gómez-Palomino, Alejandro; Pellicena, Miquel; Reina, Daniel F; Romea, Pedro; Urpí, Fèlix; Font-Bardia, Mercè

    2014-12-05

    Substrate-controlled Michael additions of the titanium(IV) enolate of lactate-derived ketone 1 to acyclic α,β-unsaturated ketones in the presence of a Lewis acid (TiCl4 or SnCl4) provide the corresponding 2,4-anti-4,5-anti dicarbonyl compounds in good yields and excellent diastereomeric ratios. Likely, the nucleophilic species involved in such additions are bimetallic enolates that may add to enones through cyclic transition states. Finally, further studies indicate that a structurally related β-benzyloxy chiral ketone can also participate in such stereocontrolled conjugate additions.

  6. One-pot construction of multiple contiguous chiral centers using Michael addition of chiral amine.

    PubMed

    Ozeki, Minoru; Ochi, Shunsuke; Hayama, Noboru; Hosoi, Shinzo; Kajimoto, Tetsuya; Node, Manabu

    2010-06-18

    Multiple contiguous chiral centers were constructed in one pot using three types of multistep reactions initiated with the Michael addition of N-benzyl-2(R)-methoxy-(+)-10-bornylamide to alpha,beta-unsaturated esters, i.e., asymmetric Michael-aldol reaction, double Michael addition, and double Michael-aldol reaction. The chiral 2-methoxy-10-bornyl group as well as the benzyl group on the amino group of the products in the Michael-aldol reaction could be easily cleaved by treatment with NIS (4 equiv), and beta-amino esters with multiple contiguous chiral centers were obtained in good yield. As an application, the beta-amino-beta'-hydroxy ester obtained in the asymmetric Michael-aldol reaction was converted to the beta-lactam derivative in good yield.

  7. Nearly Finished Genomes Produced Using Gel Microdroplet Culturing (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema

    Fitzsimmons, Michael [LANL

    2016-07-12

    Michael Fitzsimmons from Los Alamos National Laboratory gives a talk titled "Nearly Finished Genomes Produced Using Gel Microdroplet Culturing" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  8. Trisubstituted 2-trifluoromethyl pyrrolidines via catalytic asymmetric Michael addition/reductive cyclization.

    PubMed

    Corbett, Michael T; Xu, Qihai; Johnson, Jeffrey S

    2014-05-02

    The stereoselective synthesis of trisubstituted 2-trifluoromethyl pyrrolidines by asymmetric Michael addition/hydrogenative cyclization is described. The direct organocatalytic addition of 1,1,1-trifluoromethylketones to nitroolefins proceeds under mild reaction conditions and low catalyst loadings to provide Michael adducts in high yield with excellent diastereo- and enantioselectivity. Catalytic hydrogenation of the Michael adducts stereoselectively generates 2-trifluoromethylated pyrrolidines bearing three contiguous stereocenters. A stereospecific route to epimeric 2-trifluoromethyl pyrrolidines from a common intermediate is described.

  9. Enantioselective Synthesis of β-(3-Hydroxypyrazol-1-yl)ketones Using An Organocatalyzed Michael Addition Reaction

    PubMed Central

    Gogoi, Sanjib; Zhao, Cong-Gui; Ding, Derong

    2009-01-01

    β-(3-Hydroxypyrazol-1-yl)ketones have been prepared in high yields and excellent enantioselectivities (94–98% ee) via a Michael addition reaction between 2-pyrazolin-5-ones and aliphatic acyclic α,β-unsaturated ketones using 9-epi-9-amino-9-deoxyquinine as the catalyst. These results account for the first example of an aza-Michael addition of the ambident 2-pyrazolin-5-one anion to a Michael acceptor. PMID:19415906

  10. Glutathione Adduct Patterns of Michael-Acceptor Carbonyls.

    PubMed

    Slawik, Christian; Rickmeyer, Christiane; Brehm, Martin; Böhme, Alexander; Schüürmann, Gerrit

    2017-02-22

    Glutathione (GSH) has so far been considered to facilitate detoxification of soft organic electrophiles through covalent binding at its cysteine (Cys) thiol group, followed by stepwise catalyzed degradation and eventual elimination along the mercapturic acid pathway. Here we show that in contrast to expectation from HSAB theory, Michael-acceptor ketones, aldehydes and esters may form also single, double and triple adducts with GSH involving β-carbon attack at the much harder N-terminus of the γ-glutamyl (Glu) unit of GSH. In particular, formation of the GSH-N single adduct contradicts the traditional view that S alkylation always forms the initial reaction of GSH with Michael-acceptor carbonyls. To this end, chemoassay analyses of the adduct formation of GSH with nine α,β-unsaturated carbonyls employing high performance liquid chromatography and tandem mass spectrometry have been performed. Besides enriching the GSH adductome and potential biomarker applications, electrophilic N-terminus functio-nalization is likely to impair GSH homeostasis substantially through blocking the γ-glutamyl transferase catalysis of the first breakdown step of modified GSH, and thus its timely reconstitution. The discussion includes a comparison with cyclic adducts of GSH and furan metabolites as reported in literature, and quantum chemically calculated thermodynamics of hard-hard, hard-soft and soft-soft adducts.

  11. Primary-tertiary diamine-catalyzed Michael addition of ketones to isatylidenemalononitrile derivatives.

    PubMed

    Kumar, Akshay; Chimni, Swapandeep Singh

    2014-01-01

    Simple primary-tertiary diamines easily derived from natural primary amino acids were used to catalyze the Michael addition of ketones with isatylidenemalononitrile derivatives. Diamine 1a in combination with D-CSA as an additive provided Michael adducts in high yield (up to 94%) and excellent enantioselectivity (up to 99%). The catalyst 1a was successfully used to catalyze the three-component version of the reaction by a domino Knoevenagel-Michael sequence. The Michael adduct 4a was transformed into spirooxindole 6 by a reduction with sodium borohydride in a highly enantioselective manner.

  12. Dr. Marco Marra: Pioneer and Visionary in Cancer Genomics Research | Office of Cancer Genomics

    Cancer.gov

    Dr. Marco Marra is a highly distinguished genomics and bioinformatics researcher. He is the Director of Canada’s Michael Smith Genome Sciences Centre at the BC Cancer Agency and holds a faculty position at the University of British Columbia. The Centre is a state-of-the-art sequencing facility in Vancouver, Canada, with a major focus on the study of cancers.  Many of their research projects are undertaken in collaborations with other Canadian and international institutions.

  13. The need for environmental horizon scanning.

    PubMed

    Sutherland, William J; Woodroof, Harry J

    2009-10-01

    Policymakers and practitioners in most fields, including conservation and the environment, often make decisions based on insufficient evidence. One reason for this is that issues appear unexpectedly, when with hindsight, many of them were foreseeable. A solution to the problem of being insufficiently prepared is routine horizon scanning, which we describe as the systematic search for potential threats and opportunities that are currently poorly recognized. Researchers can then decide which issues might be most worthwhile to study. Practitioners can also use horizon scanning to ensure timely policy development and research procurement. Here, we suggest that horizon scanning is an underused tool that should become a standard element of environmental and conservation practice. We make recommendations for its incorporation into research, policy and practice. We argue that, as an ecological and conservation community, we are failing to provide timely advice owing to a weakness in identifying forthcoming issues. We outline possible horizon-scanning methods, and also make recommendations as to how horizon scanning could have a more central role in environmental and conservation practice.

  14. Star-Paths, Stones and Horizon Astronomy

    NASA Astrophysics Data System (ADS)

    Brady, Bernadette

    2015-05-01

    Archaeoastronomers tend to approach ancient monuments focusing on the landscape and the horizon calendar events of sun and moon and, due to problems with precession, generally ignore the movement of the stars. However, locating the position of solar calendar points on the horizon can have other uses apart from calendar and/or cosmological purposes. This paper firstly suggests that the stars do not need to be ignored. By considering the evidence of the Phaenomena, a sky poem by Aratus of Soli, a third century BC Greek poet, and his use of second millennium BC star lore fragments, this paper argues that the stars were a part of the knowledge of horizon astronomy. Aratus' poem implied that the horizon astronomy of the late Neolithic and Bronze Age periods included knowledge of star-paths or 'linear constellations' that were defined by particular horizon calendar events and other azimuths. Knowledge of such star-paths would have enabled navigation and orientation, and by using permanent markers, constructed or natural, to define these paths, they were immune to precession as the stones could redefine a star-path for a future generation. Finally the paper presents other possible intentions behind the diverse orientation of passage tombs and some megalithic sites.

  15. Asymmetric synthesis of functionalized cyclohexanes bearing five stereocenters via a one-pot organocatalytic Michael-Michael-1,2-addition sequence.

    PubMed

    Chauhan, Pankaj; Urbanietz, Gregor; Raabe, Gerhard; Enders, Dieter

    2014-07-04

    A highly stereoselective one-pot procedure involving an enantioselective Michael addition promoted by low loading of an amino-squaramide catalyst followed by an achiral base catalyzed domino Michael-Knoevenagel-type 1,2-addition sequence provides efficient access to fully substituted cyclohexanes bearing five contiguous stereogenic centers in good yields (68-86%) and excellent stereoselectivities (>30 : 1 dr and 96-99% ee).

  16. Michael Crotty and nursing phenomenology: criticism or critique?

    PubMed

    Barkway, P

    2001-09-01

    In 1996 Michael Crotty published the text Phenomenology and nursing research in which he criticised many nurse researchers' interpretation of the methodology of phenomenology and their utilisation of phenomenology as a method for undertaking qualitative nursing research. Crotty's thesis proposes that the research conducted by nurses is not phenomenology according to the European tradition, but a North American hybrid. Subsequently, debate has occurred amongst nurses as to whether Crotty's work is a scholarly, reasoned critique or a severe, judgmental, fault-finding criticism of nursing research. Considering the increasing utilisation of phenomenology as a methodology that informs nursing research, this debate is an important one and has implications for the conduct of research. This article examines this debate and the implications of Crotty's work for phenomenological research in nursing.

  17. Unprecedented Double aza-Michael Addition within a Sapphyrin Core.

    PubMed

    Figueira, Flávio; Marques, Igor; Farinha, Andreia S F; Tomé, Augusto C; Cavaleiro, José A S; Silva, Artur M S; Sessler, Jonathan; Félix, Vítor; Tomé, João P C

    2016-09-26

    A novel sapphyrin derivative was obtained from the reaction between a free-base sapphyrin and dimethyl acetylenedicarboxylate (DMAD). The formation of the new compound involved a double aza-Michael addition of two pyrrolic NH groups to a DMAD molecule, with the formation of a disubstituted ethano bridge. The NMR spectral data reveal a product with an unsymmetrical structure; DFT calculations provided support for a structure in which the ethano bridge links two adjacent pyrrole units. The present study provides a seemingly unprecedented example of an N,N'-dinucleophile reacting with DMAD to form a heterocyclic compound in which the two N-atoms are linked to the two sp(3) carbon atoms derived from a substituted acetylene.

  18. Expedition 8 Crew Interviews: C. Michael Foale - CDR

    NASA Technical Reports Server (NTRS)

    2003-01-01

    C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

  19. STS-107 Crew Interviews: Michael Anderson, Mission Specialist

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-107 Mission Specialist 3 and Payload Commander Michael Anderson is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. He outlines his role in the mission in general, and specifically in conducting onboard science experiments. He discusses the following instruments and sets of experiments in detail: CM2 (Combustion Module 2), FREESTAR (Fast Reaction Enabling Science Technology and Research, MEIDEX (Mediterranean Israeli Dust Experiment) and MGM (Mechanics of Granular Materials). Anderson also mentions on-board activities and responsibilities during launch and reentry, mission training, and microgravity research. In addition, he touches on the dual work-shift nature of the mission, the use of crew members as research subjects including pre and postflight monitoring activities, the emphasis on crew safety during training and the value of international cooperation.

  20. Chiral picolylamines for Michael and aldol reactions: probing substrate boundaries.

    PubMed

    Nugent, Thomas C; Bibi, Ahtaram; Sadiq, Abdul; Shoaib, Mohammad; Umar, M Naveed; Tehrani, Foad N

    2012-12-14

    Here we report on inroads concerning increased substrate breadth via the picolylamine organocatalyst template, a vicinal chiral diamine based on a pyridine-primary amine motif. The addition of cyclohexanone to β-nitrostyrene has many catalyst solutions, but cyclopentanone and isobutyraldehyde additions continue to be challenging. PicAm-3 (10 mol%) readily allows the Michael addition of cyclopentanone or isobutyraldehyde (5.0 equiv.) to β-nitrostyrene derivatives. By contrast, PicAm-1 (7.0 mol%) is optimal for catalyzing the aldol reaction of cyclohexanone or cycloheptanone (3.3 equiv.) with aromatic aldehydes. Eighteen products are reported and for each reaction type new products are reported (4b-d, 9c). Very good yields and stereoselectivities are generally noted. The reactions, which require an acid additive, proceed via a transient chiral enamine and a mechanistic case is put forth for a bifunctional catalysis model.

  1. STS-107 Crew Interviews: Michael Anderson, Mission Specialist

    NASA Astrophysics Data System (ADS)

    2002-06-01

    STS-107 Mission Specialist 3 and Payload Commander Michael Anderson is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. He outlines his role in the mission in general, and specifically in conducting onboard science experiments. He discusses the following instruments and sets of experiments in detail: CM2 (Combustion Module 2), FREESTAR (Fast Reaction Enabling Science Technology and Research, MEIDEX (Mediterranean Israeli Dust Experiment) and MGM (Mechanics of Granular Materials). Anderson also mentions on-board activities and responsibilities during launch and reentry, mission training, and microgravity research. In addition, he touches on the dual work-shift nature of the mission, the use of crew members as research subjects including pre and postflight monitoring activities, the emphasis on crew safety during training and the value of international cooperation.

  2. STS-94 Mission Specialist Michael Gernhardt suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-94 Mission Specialist Michael L. Gernhardt is assisted into his launch/entry suit by a suit technician in the Operations and Checkout (O&C) Building. He first flew in this capacity on STS- 69. He has been a professional deep sea diver and engineer and holds a doctorate in bioengineering. Gernhardt will be in charge of the Blue shift and as flight engineer will operate and maintain the orbiter while Halsell and Still are asleep as members of the Red shift. He will also back them up on the flight deck during the ascent and re-entry phases of the mission. Gernhardt and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Columbia will lift off during a launch window that opens at 1:50 a.m. EDT, July opportunity to lift off before Florida summer rain showers reached the space center.

  3. STS-83 Mission Specialist Michael L. Gernhardt suits up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-83 Mission Specialist Michael L. Gernhardt is assisted into his launch/entry suit in the Operations and Checkout (O&C) Building. He first flew in this capacity on STS-69. He has been a professional deep sea diver and engineer and holds a doctorate in bioengineering. Gernhardt will be in charge of the Blue shift and as flight engineer will operate and maintain the orbiter while Halsell and Still are asleep as members of the Red shift. He will also back them up on the flight deck during the ascent and re- entry phases of the mission. Gernhardt and six fellow crew members will shortly depart the O&C and head for Launch Pad 39A, where the Space Shuttle Columbia will lift off during a launch window that opens at 2:00 p.m. EST, April 4.

  4. Horizon thermodynamics in fourth-order gravity

    NASA Astrophysics Data System (ADS)

    Ma, Meng-Sen

    2017-03-01

    In the framework of horizon thermodynamics, the field equations of Einstein gravity and some other second-order gravities can be rewritten as the thermodynamic identity: dE = TdS - PdV. However, in order to construct the horizon thermodynamics in higher-order gravity, we have to simplify the field equations firstly. In this paper, we study the fourth-order gravity and convert it to second-order gravity via a so-called ;Legendre transformation; at the cost of introducing two other fields besides the metric field. With this simplified theory, we implement the conventional procedure in the construction of the horizon thermodynamics in 3 and 4 dimensional spacetime. We find that the field equations in the fourth-order gravity can also be written as the thermodynamic identity. Moreover, we can use this approach to derive the same black hole mass as that by other methods.

  5. 77 FR 41181 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. Massachusetts...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey... (PURPA), CAlifornians for Renewable Energy, Inc., Michael E. Boyd, and Robert M. Sarvey...

  6. Highly enantioselective organocatalytic Michael addition of nitroalkanes to 4-oxo-enoates.

    PubMed

    Lu, Hai-Hua; Wang, Xu-Fan; Yao, Chang-Jiang; Zhang, Jian-Ming; Wu, Hong; Xiao, Wen-Jing

    2009-07-28

    A useful Michael addition reaction using nitroalkanes as the nucleophile and 4-oxo-enoates as the Michael acceptor has been disclosed, and the reaction allows expedient access to functionalized chiral gamma-keto esters in high yields and excellent enantioselectivities (up to 98% ee), with a low catalyst loading.

  7. Chiral primary amine catalyzed asymmetric Michael addition of malononitrile to α-substituted vinyl ketone.

    PubMed

    Fu, Niankai; Zhang, Long; Luo, Sanzhong

    2015-01-16

    The first efficient and highly enantioselective Michael addition-protonation reaction of malononitriles to α-substituted vinyl ketones has been developed by using a chiral primary amine as the organocatalyst. With a Hantzsch ester as the hydride source, an enantioselective tandem reduction, Michael addition-protonation reaction of benzylidenemalononitrile has also been achieved with good yields and high enantioselectivities.

  8. 75 FR 22436 - Michael Williams-Control Exemption-St. Maries River Railroad, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Surface Transportation Board Michael Williams-Control Exemption-St. Maries River Railroad, Inc. Michael Williams (applicant),\\1\\ a noncarrier, has filed a verified notice of exemption to acquire control of St... from STMA's parent, Potlatch Land & Lumber, LLC, by Williams Group, Inc. (WG).\\2\\ Applicant...

  9. A Response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts"

    ERIC Educational Resources Information Center

    Cranton, Patricia; Kasl, Elizabeth

    2012-01-01

    This article presents the authors' response to Michael Newman's "Calling Transformative Learning into Question: Some Mutinous Thoughts". The authors begin by noting their appreciation of Michael Newman's challenge to transformative learning theory. In their response, the authors review and comment on the fatal flaws presented by Newman and then…

  10. Studying Teachers and Schools: Michael Pressley's Legacy and Directions for Future Research

    ERIC Educational Resources Information Center

    Mohan, Lindsey; Lundeberg, Mary A.; Reffitt, Kelly

    2008-01-01

    Much of Michael Pressley's work during the past decade focused on the nature of highly effective, engaging literacy instruction. Michael Pressley believed that studying effective teachers and schools had the potential to influence more engaging and effective teaching, especially in underresourced schools. First, we describe the grounded…

  11. 77 FR 61596 - Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing Take notice that on September 28, 2012, Michael I. Wheatley and Drummond E. Garrison submitted for filing,...

  12. Aerosol physical properties from satellite horizon inversion

    NASA Technical Reports Server (NTRS)

    Gray, C. R.; Malchow, H. L.; Merritt, D. C.; Var, R. E.; Whitney, C. K.

    1973-01-01

    The feasibility is investigated of determining the physical properties of aerosols globally in the altitude region of 10 to 100 km from a satellite horizon scanning experiment. The investigation utilizes a horizon inversion technique previously developed and extended. Aerosol physical properties such as number density, size distribution, and the real and imaginary components of the index of refraction are demonstrated to be invertible in the aerosol size ranges (0.01-0.1 microns), (0.1-1.0 microns), (1.0-10 microns). Extensions of previously developed radiative transfer models and recursive inversion algorithms are displayed.

  13. Global and local horizon quantum mechanics

    NASA Astrophysics Data System (ADS)

    Casadio, Roberto; Giugno, Andrea; Giusti, Andrea

    2017-02-01

    Horizons are classical causal structures that arise in systems with sharply defined energy and corresponding gravitational radius. A global gravitational radius operator can be introduced for a static and spherically symmetric quantum mechanical matter state by lifting the classical "Hamiltonian" constraint that relates the gravitational radius to the ADM mass, thus giving rise to a "horizon wave-function". This minisuperspace-like formalism is shown here to be able to consistently describe also the local gravitational radius related to the Misner-Sharp mass function of the quantum source, provided its energy spectrum is determined by spatially localised modes.

  14. Horizon detection and higher dimensional black rings

    NASA Astrophysics Data System (ADS)

    Coley, A. A.; McNutt, D. D.

    2017-02-01

    In this paper we study the stationary horizons of the rotating black ring and the supersymmetric black ring spacetimes in five dimensions. In the case of the rotating black ring we use Weyl aligned null directions to algebraically classify the Weyl tensor, and utilize an adapted Cartan algorithm in order to produce Cartan invariants. For the supersymmetric black ring we employ the discriminant approach and repeat the adapted Cartan algorithm. For both of these metrics we are able to construct Cartan invariants that detect the horizon alone, and which are easier to compute and analyse than scalar polynomial curvature invariants.

  15. Expanding your horizons in science and mathematics

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Through the presentation of its Expanding Your Horizons in Science and Mathematics career education conferences for secondary school young women, the Math/Science Network continues its efforts to remove the educational, psychological, and cultural barriers which prevent women from entering math-and science-based careers. The Expanding Your Horizons conferences were presented on 77 college, university and high school campuses across the United States. This year, these unique one day conferences reached 15,500 students, 3,000 parents and educators, and involved 3,000 career women who volunteered their services as conference planners, workshop leaders, speakers, and role models.

  16. Classification of Near-Horizon Geometries of Extremal Black Holes.

    PubMed

    Kunduri, Hari K; Lucietti, James

    2013-01-01

    Any spacetime containing a degenerate Killing horizon, such as an extremal black hole, possesses a well-defined notion of a near-horizon geometry. We review such near-horizon geometry solutions in a variety of dimensions and theories in a unified manner. We discuss various general results including horizon topology and near-horizon symmetry enhancement. We also discuss the status of the classification of near-horizon geometries in theories ranging from vacuum gravity to Einstein-Maxwell theory and supergravity theories. Finally, we discuss applications to the classification of extremal black holes and various related topics. Several new results are presented and open problems are highlighted throughout.

  17. Gateway's Horizon: A Center of Excellence

    ERIC Educational Resources Information Center

    Herring, Jayne; Colony, Lee

    2007-01-01

    This article describes Gateway Technical College's Horizon Center for Transportation Technology, located in Kenosha, Wisconsin, which was the product of collaboration with business and industry, community support and a U.S. Department of Labor (DOL) grant. The center, which opened this fall, is a prime example of a sustainable community…

  18. Senior Adult Bands: Music's New Horizon.

    ERIC Educational Resources Information Center

    Coffman, Don D.; Levy, Katherine M.

    1997-01-01

    Discusses the success of Iowa City's (Iowa) New Horizons Band that consists of 55 senior adult beginners and former instrumentalists. Describes the organization of the band program, the senior's performance skills and commitment, and the ongoing challenges. Gives a selected listing of the music the band plays at concerts and other events. (CMK)

  19. Teachers' Beliefs about Mathematical Horizon Content Knowledge

    ERIC Educational Resources Information Center

    Mosvold, Reidar; Fauskanger, Janne

    2014-01-01

    In this article, we present and discuss an example of how teachers' discussions of mathematical knowledge for teaching (MKT) items elicited their beliefs about the knowledge needed to teach mathematics. One category of MKT is "horizon content knowledge," and this can be described as mathematical knowledge not directly deployed in…

  20. HIGHER HORIZONS, A PROGRAM FOR YOUR CHILD.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY.

    PARENTS ARE TOLD THAT HIGHER HORIZONS WILL HELP DEVELOP THE CAPACITIES OF EVERY CHILD, INCREASE HIS SELF CONFIDENCE, AND HELP HIM COMPLETE HIGH SCHOOL. RESULTS OF TESTS AND INTERVIEWS TO DISCOVER A CHILD'S ABILITIES, INTERESTS, AND NEEDS ARE DISCUSSED IN PARENT-TEACHER CONFERENCES. INSTRUCTION IS AIMED AT DEVELOPING ABILITIES. THE CHILD IS…

  1. Space Launch Initiative: New Capabilities - New Horizons

    NASA Technical Reports Server (NTRS)

    Dumbacher, Daniel; Smith, Dennis E. (Technical Monitor)

    2002-01-01

    This paper presents NASA's Space Launch Initiative (SLI) with new capabilities and new horizons. The topics include: 1) Integrated Space Transportation Plan; 2) SLI: The Work of a Nation; 3) SLI Goals and Status; 4) Composites and Materials; and 5) SLI and DOD/USAF Collaboration. This paper is in viewgraph form.

  2. New Concepts on the Educational Horizon.

    ERIC Educational Resources Information Center

    Gilchrist, Robert S.; Mitchell, Edna

    Four dimensions in education provide a basis for discussing future horizons: (1) curriculum development, (2) teacher education, (3) administration and organization, and (4) research and development. These areas are interdependent, and one cannot be improved or changed without affecting the other areas. Within these areas, some of the broad changes…

  3. Finite Horizon H Infinity with Parameter Variations

    DTIC Science & Technology

    1992-05-01

    International Journal of Robust and Nonlinear Control, to appear. SUBRAHMANYAM, M. B., 1992d, Worst-case optimal control over a finite horizon, Journal of Mathematical Analysis and Applications , to...in linear systems, Journal of Mathematical Analysis and Applications , 164, 130-150. SUBRAHMANYAM, M. B., 1991, H, 0 optimal control theory over a

  4. Sighting Horizons of Teaching in Higher Education

    ERIC Educational Resources Information Center

    Barnett, Ronald; Guzmán-Valenzuela, Carolina

    2017-01-01

    This conceptual paper tackles the matter of teaching in higher education and proposes a concept of "horizons of teaching." It firstly offers an overview of the considerable empirical literature around teaching--especially conceptions of teaching, approaches to teaching and teaching practices--and goes on to pose some philosophical and…

  5. The NMC Horizon Report: 2013 Museum Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Freeman, A.

    2013-01-01

    The "NMC Horizon Report: 2013 Museum Edition," is a co-production with the Marcus Institute for Digital Education in the Arts (MIDEA), and examines six emerging technologies for their potential impact on and use in education and interpretation within the museum environment: BYOD (Bring Your Own Device), crowdsourcing, electronic…

  6. Falling through the black hole horizon

    NASA Astrophysics Data System (ADS)

    Brustein, Ram; Medved, A. J. M.

    2015-06-01

    We consider the fate of a small classical object, a "stick", as it falls through the horizon of a large black hole (BH). Classically, the equivalence principle dictates that the stick is affected by small tidal forces, and Hawking's quantum-mechanical model of BH evaporation makes essentially the same prediction. If, on the other hand, the BH horizon is surrounded by a "firewall", the stick will be consumed as it falls through. We have recently extended Hawking's model by taking into account the quantum fluctuations of the geometry and the classical back-reaction of the emitted particles. Here, we calculate the train exerted on the falling stick for our model. The strain depends on the near-horizon state of the Hawking pairs. We find that, after the Page time when the state of the pairs deviates significantly from maximal entanglement (as required by unitarity), the induced strain in our semiclassical model is still parametrically small. This is because the number of the disentangled pairs is parametrically smaller than the BH entropy. A firewall does, however, appear if the number of disentangled pairs near the horizon is of order of the BH entropy, as implicitly assumed in previous discussions in the literature.

  7. Switchable stereocontrolled divergent synthesis induced by aza-Michael addition of deactivated primary amines under acid catalysis.

    PubMed

    Amara, Z; Drège, E; Troufflard, C; Retailleau, P; Tran Huu-Dau, M-E; Joseph, D

    2014-11-24

    Switchable tandem intramolecular aza-Michael/Michael and double aza-Michael reactions allow the oriented synthesis of highly functionalised cyclic skeletons. Conjugate addition of deactivated anilines triggers chemo- and stereo-divergent ring-closure reaction pathways with a striking selectivity depending on reaction conditions.

  8. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... approximately 7.5 acres of airport property, located at the Michael J Smith Field, be used for aeronautical... Authority to release approximately 7.5 acres of airport property at the Michael J Smith Field. The...

  9. Soft hairs on isolated horizon implanted by electromagnetic fields

    NASA Astrophysics Data System (ADS)

    Mao, Pujian; Wu, Xiaoning; Zhang, Hongbao

    2017-03-01

    Inspired by the recent proposal of soft hair on black holes in Hawking et al (2016 Phys. Rev. Lett. 116 231301), we have shown that an isolated horizon carries soft hairs implanted by electromagnetic fields. The solution space and the asymptotic symmetries of Einstein–Maxwell theory have been worked out explicitly near the isolated horizon. The conserved current has been computed and an infinite number of near horizon charges have been introduced from the electromagnetic fields associated with the asymptotic U(1) symmetry near the horizon, which indicates the fact that the isolated horizon carries a large amount of soft electric hairs. The soft electric hairs, i.e. asymptotic U(1) charges, are shown to be equivalent to the electric multipole moments of isolated horizons. It is further argued that the isolated horizon supertranslation is from the ambiguity of its foliation and an analogue of memory effect on horizon can be expected.

  10. The Pluto System As Seen By New Horizons Spacecraft

    NASA Video Gallery

    The Pluto system as NASA’s New Horizons spacecraft saw it in July 2015. This animation, made with real images taken by New Horizons, begins with Pluto flying in for its close-up on July 14; we then...

  11. SETAC launches global horizon scanning/research prioritization project

    EPA Science Inventory

    The SETAC World Council is pleased to announce the initiation of a Global Horizon Scanning and Prioritization Project aimed at identifying geographically specific research needs to address stressor impacts on environmental quality. In recent years, horizon scanning and research ...

  12. Michael Tuomey's 1848 geological survey of South Carolina

    USGS Publications Warehouse

    Nystrom, P.G.

    1999-01-01

    One hundred and fifty years ago, Michael Tuomey completed his 'Report on the Geology of South Carolina,' the result of four years of arduous labor. The report is the first detailed and comprehensive geological description of the entire state, and it includes a geological map that shows the distribution of Coastal Plain and Piedmont-Blue Ridge units. In the sesquicentennial of Tuomey's survey, it is fitting that we recognize his important early contribution to the geology of South Carolina and the southeast. Tuomey's report is a 293-page volume with a 48-page appendix and an index. Although he gave a complete depiction of Coastal Plain geology and delineated Cretaceous, Lower Eocene, Eocene, Miocene, Post-Pliocene, and alluvial units on his map, the emphasis herein is on his mapping of the Piedmont and Blue Ridge. The metamorphic units he delineated are clay slate, mica slate, talcose slate, hornblende slate, gneiss, and lime rock. Gneiss is the most extensive unit on the map. His map shows many elements of the geologic framework we recognize today. The distribution of his clay slate unit corresponds closely with the Carolina slate and Bel Air belts as we know them now. The gneiss between the two clay slate areas matches the Kiokee belt. Areas of mica slate approximate the northern part of the Kings Mountain belt and the Chauga belt. He also recognized that his talcose slate unit was associated with gold deposits. Granitic and basaltic intrusive rocks are also delineated on the map. It shows the Newberry, Columbia, and Liberty Hill granites we recognize today. Basaltic intrusives outlined include the Bush River of western Newberry County, Dutchmans Creek, Big Wateree Creek, and Ogden gabbros. He described the regional extent of diabase dikes as occuring from Virginia to Alabama, noted their preferred direction and diagrammed their near-vertical orientation. He also referred to the distinctive soil and topography that develops on the large gabbros. Michael Tuomey

  13. Diastereoselective syntheses of substituted cis-hydrindanones featuring sequential inter- and intramolecular Michael reactions.

    PubMed

    Liu, Junjia; Marsini, Maurice A; Bedell, T Aaron; Reider, Paul J; Sorensen, Erik J

    2016-06-30

    The hydrindane (bicyclo[4.3.0]nonane) structural motif (1) and related cis-1-hydrindanone skeleton (2) are common substructures in many natural products. Herein, we describe efficient access to substituted cis-1-hydrindanones enabled by a sequence of Michael reactions. A copper-catalyzed intermolecular Michael addition of a cyclic silyl ketene acetal to a β-substituted-α-alkoxycarbonyl-cyclopentenone enables construction of a quaternary center and is followed, after incorporation of an additional Michael acceptor, by a second, intramolecular addition of a nucleophilic β-ketoester. This strategy affords stereoselective access to substituted bicyclic cis-hydrindanone ring systems containing up to three contiguous stereocenters.

  14. Organocatalytic asymmetric Michael addition of 5H-oxazol-4-ones to nitroolefins.

    PubMed

    Qiao, Baokun; An, Yongqiang; Liu, Qian; Yang, Wenguo; Liu, Hongjun; Shen, Juan; Yan, Lin; Jiang, Zhiyong

    2013-05-17

    The first organocatalytic asymmetric Michael addition of 5H-oxazol-4-ones to nitroolefins has been developed. In the presence of easily prepared L-tert-leucine-derived tertiary amine/thiourea catalyst, the Michael addition of 5H-oxazol-4-ones to nitroolefins proceeded in an excellent diastereo- and enantioselective manner (up to 99% ee and >19:1 dr). The Michael adducts obtained are valuable precursors for the synthesis of chiral α-alkyl-α-hydroxy carboxylic acid derivatives, which represent a series of versatile building blocks in many biologically active compounds.

  15. Asymmetric Michael addition of ketones to nitroolefins: pyrrolidinyl-oxazole-carboxamides as new efficient organocatalysts.

    PubMed

    Kamal, Ahmed; Sathish, Manda; Srinivasulu, Vunnam; Chetna, Jadala; Chandra Shekar, Kunta; Nekkanti, Shalini; Tangella, Yellaiah; Shankaraiah, Nagula

    2014-10-28

    Chiral pyrrolidinyl-oxazole-carboxamides were synthesized and used as efficient new organocatalysts for the asymmetric Michael addition of ketones with nitroalkenes under solvent-free conditions. Gratifyingly, the corresponding Michael adducts were obtained in higher yields (up to 99%) and excellent stereoselectivities (up to >99/1 dr and 99% ee). Transition state models have been proposed to account for the high enantio- and diastereoselectivity of these Michael addition reactions and also the energetics have been investigated using density functional methods. These results support the preferential formation of syn-products by the approach of trans-β-nitrostyrene through the re-face of anti-enamine.

  16. STS-103 M.S. Michael Foale during TCDT activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    STS-103 Mission Specialist C. Michael Foale (Ph.D.) is ready to take his turn at driving a small armored personnel carrier that is part of emergency egress training during Terminal Countdown Demonstration Test (TCDT) activities. The tracked vehicle could be used by the crew in the event of an emergency at the pad during which the crew must make a quick exit from the area. The TCDT also provides simulated countdown exercises and opportunities to inspect the mission payloads in the orbiter's payload bay. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The other STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists Steven L. Smith , John M. Grunsfeld (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, who are with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

  17. Status of the JPL Horizons Ephemeris System

    NASA Astrophysics Data System (ADS)

    Giorgini, Jon D.

    2015-08-01

    Since 1996, the NASA/Jet Propulsion Laboratory on-line Horizons system has provided open access to the latest JPL orbit solutions through customizable ephemeris generation and searches. Currently, high-precision ephemerides for more than 683,000 objects are available: all known solar system bodies, several dozen spacecraft, system barycenters, and some libration points.Since inception, Horizons has produced 150 million ephemeris products in response to 70.4 million connections by 800,000 unique IP addresses. Recent usage is typically 6000 unique users requesting 4,000,000 ephemeris products per month.Horizons is freely accessible without an account and may be used and automated through any of three interfaces: interactive telnet connection, web-browser form, or by sending e-mail command-files.Asteroid and comet ephemerides are numerically integrated on request using JPL's DASTCOM5 database of initial conditions which is kept current by a separate process; as new measurements and discoveries are reported by the Minor Planet Center, they are automatically processed into new JPL orbit solutions. Radar targets and other objects of high interest have their orbit solutions manually examined and updated into the database.For asteroids and comets, SPK files may be dynamically created using Horizons. This is effectively a recording of the integrator output. The binary files may then be efficiently interpolated by user software to exactly reproduce the trajectory without having to duplicate the numerically integrated n-body dynamical model or PPN equations of motion.Other Horizons output is numerical and in the form of plain-text observer, vector, osculating element, and close-approach tables. More than one hundred quantities can be requested in various time-scales and coordinate systems. For asteroids and comets, statistical uncertainties can be mapped to output times to assess position and motion uncertainties.Horizons is consistent with the DE431 solar system solution

  18. Fiber-optical analog of the event horizon.

    PubMed

    Philbin, Thomas G; Kuklewicz, Chris; Robertson, Scott; Hill, Stephen; König, Friedrich; Leonhardt, Ulf

    2008-03-07

    The physics at the event horizon resembles the behavior of waves in moving media. Horizons are formed where the local speed of the medium exceeds the wave velocity. We used ultrashort pulses in microstructured optical fibers to demonstrate the formation of an artificial event horizon in optics. We observed a classical optical effect: the blue-shifting of light at a white-hole horizon. We also showed by theoretical calculations that such a system is capable of probing the quantum effects of horizons, in particular Hawking radiation.

  19. Rogue events in the group velocity horizon

    PubMed Central

    Demircan, Ayhan; Amiranashvili, Shalva; Brée, Carsten; Mahnke, Christoph; Mitschke, Fedor; Steinmeyer, Günter

    2012-01-01

    The concept of rogue waves arises from a mysterious and potentially calamitous phenomenon of oceanic surfaces. There is mounting evidence that they are actually commonplace in a variety of different physical settings. A set of defining criteria has been advanced; this set is of great generality and therefore applicable to a wide class of systems. The question arises naturally whether there are generic mechanisms responsible for extreme events in different systems. Here we argue that under suitable circumstances nonlinear interaction between weak and strong waves results in intermittent giant waves with all the signatures of rogue waves. To obtain these circumstances only a few basic conditions must be met. Then reflection of waves at the so-called group-velocity horizon occurs. The connection between rogue waves and event horizons, seemingly unrelated physical phenomena, is identified as a feature common in many different physical systems. PMID:23152941

  20. Rogue events in the group velocity horizon.

    PubMed

    Demircan, Ayhan; Amiranashvili, Shalva; Brée, Carsten; Mahnke, Christoph; Mitschke, Fedor; Steinmeyer, Günter

    2012-01-01

    The concept of rogue waves arises from a mysterious and potentially calamitous phenomenon of oceanic surfaces. There is mounting evidence that they are actually commonplace in a variety of different physical settings. A set of defining criteria has been advanced; this set is of great generality and therefore applicable to a wide class of systems. The question arises naturally whether there are generic mechanisms responsible for extreme events in different systems. Here we argue that under suitable circumstances nonlinear interaction between weak and strong waves results in intermittent giant waves with all the signatures of rogue waves. To obtain these circumstances only a few basic conditions must be met. Then reflection of waves at the so-called group-velocity horizon occurs. The connection between rogue waves and event horizons, seemingly unrelated physical phenomena, is identified as a feature common in many different physical systems.

  1. Quantum correlations across the black hole horizon

    SciTech Connect

    Schuetzhold, Ralf; Unruh, William G.

    2010-06-15

    Inspired by the condensed-matter analogues of black holes, we study the quantum correlations across the event horizon reflecting the entanglement between the outgoing particles of the Hawking radiation and their in-falling partners. For a perfectly covariant theory, the total correlation is conserved in time and piles up arbitrary close to the horizon in the past, where it merges into the singularity of the vacuum two-point function at the light cone. After modifying the dispersion relation (i.e., breaking Lorentz invariance) for large k, on the other hand, the light cone is smeared out and the entanglement is not conserved but actually created in a given rate per unit time.

  2. Horizon Missions Technology Study. [for space exploration

    NASA Technical Reports Server (NTRS)

    Anderson, John L.

    1992-01-01

    The purpose of the HMT Study was to develop and demonstrate a systematic methodology for identifying and evaluating innovative technology concepts offering revolutionary, breadkthrough-type capabilities for advanced space missions and for assessing their potential mission impact. The methodology is based on identifying the new functional, operational and technology capabilities needed by hypothetical 'Horizon' space missions that have performance requirements that cannot be met, even by extrapolating known space technologies. Nineteen Horizon Missions were selected to represent a collective vision of advanced space missions of the mid-21st century. The missions typically would occur beyond the lifetime of current or planned space assets. The HM methodology and supporting data base may be used for advanced technology planning, advanced mission planning and multidisciplinary studies and analyses.

  3. Dynamical AdS strings across horizons

    SciTech Connect

    Ishii, Takaaki; Murata, Keiju

    2016-03-01

    We examine the nonlinear classical dynamics of a fundamental string in anti-deSitter spacetime. The string is dual to the flux tube between an external quark-antiquark pair in $N = 4$ super Yang-Mills theory. We perturb the string by shaking the endpoints and compute its time evolution numerically. We find that with sufficiently strong perturbations the string continues extending and plunges into the Poincare´ horizon. In the evolution, effective horizons are also dynamically created on the string worldsheet. The quark and antiquark are thus causally disconnected, and the string transitions to two straight strings. The forces acting on the endpoints vanish with a power law whose slope depends on the perturbations. Lastly, the condition for this transition to occur is that energy injection exceeds the static energy between the quark-antiquark pair.

  4. Dynamical AdS strings across horizons

    DOE PAGES

    Ishii, Takaaki; Murata, Keiju

    2016-03-01

    We examine the nonlinear classical dynamics of a fundamental string in anti-deSitter spacetime. The string is dual to the flux tube between an external quark-antiquark pair in $N = 4$ super Yang-Mills theory. We perturb the string by shaking the endpoints and compute its time evolution numerically. We find that with sufficiently strong perturbations the string continues extending and plunges into the Poincare´ horizon. In the evolution, effective horizons are also dynamically created on the string worldsheet. The quark and antiquark are thus causally disconnected, and the string transitions to two straight strings. The forces acting on the endpoints vanishmore » with a power law whose slope depends on the perturbations. Lastly, the condition for this transition to occur is that energy injection exceeds the static energy between the quark-antiquark pair.« less

  5. Polarimetry with the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Johnson, Michael; Doeleman, Sheperd; Fish, Vincent L.; Plambeck, Richard L.; Marrone, Daniel P.; Kosowsky, Michael; Wardle, John F. C.; Lu, Rusen

    2014-06-01

    The Event Horizon Telescope (EHT) is an effort to develop millimeter and submillimeter VLBI to image nearby black holes at resolutions comparable to their event horizons. Past work with the EHT has measured compact emission on such scales for Sgr A* and M87, and has also measured sub-parsec structure in more distant quasars. Polarimetry with the EHT enables a powerful extension of this work, mapping magnetic field structures via the highly polarized synchrotron emission. Polarization is also an excellent probe of rapid variability, especially for Sgr A*, and can convey rich astrometric information even with incomplete imaging. We report on results from our 2013 campaign, which demonstrate a sharp increase in the linear polarization fraction and variability with increasing baseline, and we demonstrate that current EHT data can potentially achieve microarcsecond relative astrometry of flaring regions on timescales of minutes.

  6. Quantum amplification effect in a horizon fluctuation

    SciTech Connect

    Ansari, Mohammad H.

    2010-05-15

    The appearance of a few unevenly spaced bright flashes of light on top of Hawking radiation is the sign of the amplification effect in black hole horizon fluctuations. Previous studies on this problem suffer from the lack of considering all emitted photons in the theoretical spectroscopy of these fluctuations. In this paper, we include all of the physical transition weights and present a consistent intensity formula. This modifies a black hole radiation pattern.

  7. Gribov horizon beyond the Landau gauge

    NASA Astrophysics Data System (ADS)

    Lavrov, Peter M.; Lechtenfeld, Olaf

    2013-10-01

    Gribov and Zwanziger proposed a modification of Yang-Mills theory in order to cure the Gribov copy problem. We employ field-dependent BRST transformations to generalize the Gribov-Zwanziger model from the Landau gauge to general Rξ gauges. The Gribov horizon functional is presented in explicit form, in both the non-local and local variants. Finally, we show how to reach any given gauge from the Landau one.

  8. New Horizons Pluto Flyby Guest Operations

    NASA Astrophysics Data System (ADS)

    Simon, M.; Turney, D.; Fisher, S.; Carr, S. S.

    2015-12-01

    On July 14, 2015, after 9.5 years of cruise, NASA's New Horizons spacecraft flew past the Pluto system to gather first images humankind had ever seen on Pluto and its five moons. While much has been discovered about the Pluto system since New Horizons launch in 2006, the system has never been imaged at high resolution and anticipation of the "First Light" of the Pluto system had been anticipated by planetary enthusiasts for decades. The Johns Hopkins Applied Physics Laboratory (APL), which built and operates New Horizons, was the focal point for gathering three distinct groups: science and engineering team members; media and public affairs representatives; and invited public, including VIP's. Guest operations activities were focused on providing information primarily to the invited public and VIP's. High level objectives for the Guest Operations team was set to entertain and inform the general public, offer media reaction shots, and to deconflict activities for the guests from media activities wherever possible. Over 2000 people arrived at APL in the days surrounding closest approach for guest, science or media operations tracks. Reaction and coverage of the Guest Operations events was universally positive and global in impact: iconic pictures of the auditorium waving flags during the moment of closest approach were published in media outlets on every continent. Media relations activities ensured coverage in all key media publications targeted for release, such as the New York Times, Science, Le Monde, and Nature. Social and traditional media coverage of the events spanned the globe. Guest operations activities are designed to ensure that a guest has a memorable experience and leaves with a lifelong memory of the mission and their partnership in the activity. Results, lessons learned, and other data from the New Horizons guest operations activity will be presented and analyzed.

  9. Cascade dearomatization of N-substituted tryptophols via Lewis acid-catalyzed Michael reactions.

    PubMed

    Liu, Chuan; Zhang, Wei; Dai, Li-Xin; You, Shu-Li

    2012-09-21

    Lewis acid-catalyzed cascade dearomatization of N-substituted tryptophols via Michael addition reaction was developed. The generality of the method has been demonstrated by the synthesis of versatile furoindoline derivatives with a quaternary carbon center in good yields.

  10. High Blood Cholesterol Q&A Dr. Michael Lauer | NIH MedlinePlus the Magazine

    MedlinePlus

    ... this page please turn Javascript on. Feature: High Cholesterol High Blood Cholesterol Q&A with Dr. Michael Lauer Past Issues / ... heavier and older, what does recent research on cholesterol and heart health tell us that Americans need ...

  11. Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to alpha,beta-unsaturated ketones.

    PubMed

    Li, Pengfei; Wang, Yongcan; Liang, Xinmiao; Ye, Jinxing

    2008-07-28

    Cinchona alkaloid derived primary amine thioureas organocatalyzed Michael addition of nitroalkanes to enones in good yield and up to 98% ee and offered a new way to construct quaternary stereocenters from enones and nitroalkanes.

  12. Michael F. Vaccaro Honors Attorney Fellowship Program in our Philadelphia (Region 3) Office

    EPA Pesticide Factsheets

    The Michael F. Vaccaro Honors Attorney Fellowship provides a unique opportunity to practice law in a major governmental environmental organization, and to receive extensive training in and exposure to environmental law and policy work in the public sector.

  13. Tandem bis-aza-Michael addition reaction of amines in aqueous medium promoted by polystyrenesulfonic Acid

    EPA Science Inventory

    An efficient and environmentally benign tandem bis-aza-Michael addition of amines catalyzed by polystyrene sulfonic acid (PSSA) is described. This operationally simple high yielding microwave assisted synthetic protocol proceeded in water in the absence of any organic solvent.

  14. Using Michael Ondaatje's "The English Patient" To Teach World History: From Herodotus to Hiroshima.

    ERIC Educational Resources Information Center

    Alkana, Linda Kelly

    2000-01-01

    Describes the content of the book "The English Patient" (Michael Ondaatje) and presents teaching strategies. Focuses on the major themes in the book and the four characters who reside at an Italian villa during World War II. (CMK)

  15. Helical-Peptide-Catalyzed Enantioselective Michael Addition Reactions and Their Mechanistic Insights.

    PubMed

    Ueda, Atsushi; Umeno, Tomohiro; Doi, Mitsunobu; Akagawa, Kengo; Kudo, Kazuaki; Tanaka, Masakazu

    2016-08-05

    Helical peptide foldamer catalyzed Michael addition reactions of nitroalkane or dialkyl malonate to α,β-unsaturated ketones are reported along with the mechanistic considerations of the enantio-induction. A wide variety of α,β-unsaturated ketones, including β-aryl, β-alkyl enones, and cyclic enones, were found to be catalyzed by the helical peptide to give Michael adducts with high enantioselectivities (up to 99%). On the basis of X-ray crystallographic analysis and depsipeptide study, the amide protons, N(2)-H and N(3)-H, at the N terminus in the α-helical peptide catalyst were crucial for activating Michael donors, while the N-terminal primary amine activated Michael acceptors through the formation of iminium ion intermediates.

  16. Theory and practice in action: the contributions of Michael Perkins to clinical linguistics.

    PubMed

    Damico, Jack S; Lynch, Karen E

    2013-01-01

    This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.

  17. Gravitational memory charges of supertranslation and superrotation on Rindler horizons

    NASA Astrophysics Data System (ADS)

    Hotta, Masahiro; Trevison, Jose; Yamaguchi, Koji

    2016-10-01

    In a Rindler-type coordinate system spanned in a region outside of a black hole horizon, we have nonvanishing classical holographic charges as soft hairs on the horizon for stationary black holes. Taking a large black hole mass limit, the spacetimes with the charges are described by asymptotic Rindler metrics. We construct a general theory of gravitational holographic charges for a (1 +3 )-dimensional linearized gravity field in the Minkowski background with Rindler horizons. Although matter crossing a Rindler horizon causes horizon deformation and a time-dependent coordinate shift—that is, gravitational memory—the supertranslation and superrotation charges on the horizon can be defined during and after its passage through the horizon. It is generally proven that holographic states on the horizon cannot store any information about absorbed perturbative gravitational waves. However, matter crossing the horizon really excites holographic states. By using gravitational memory operators, which consist of the holographic charge operators, we suggest a resolution of the no-cloning paradox of quantum information between matter falling into the horizon and holographic charges on the horizon from the viewpoint of the contextuality of quantum measurement.

  18. Accurate, reliable prototype earth horizon sensor head

    NASA Technical Reports Server (NTRS)

    Schwarz, F.; Cohen, H.

    1973-01-01

    The design and performance is described of an accurate and reliable prototype earth sensor head (ARPESH). The ARPESH employs a detection logic 'locator' concept and horizon sensor mechanization which should lead to high accuracy horizon sensing that is minimally degraded by spatial or temporal variations in sensing attitude from a satellite in orbit around the earth at altitudes in the 500 km environ 1,2. An accuracy of horizon location to within 0.7 km has been predicted, independent of meteorological conditions. This corresponds to an error of 0.015 deg-at 500 km altitude. Laboratory evaluation of the sensor indicates that this accuracy is achieved. First, the basic operating principles of ARPESH are described; next, detailed design and construction data is presented and then performance of the sensor under laboratory conditions in which the sensor is installed in a simulator that permits it to scan over a blackbody source against background representing the earth space interface for various equivalent plant temperatures.

  19. Towards Assessing the Human Trajectory Planning Horizon

    PubMed Central

    Nitsch, Verena; Meinzer, Dominik; Wollherr, Dirk

    2016-01-01

    Mobile robots are envisioned to cooperate closely with humans and to integrate seamlessly into a shared environment. For locomotion, these environments resemble traversable areas which are shared between multiple agents like humans and robots. The seamless integration of mobile robots into these environments requires accurate predictions of human locomotion. This work considers optimal control and model predictive control approaches for accurate trajectory prediction and proposes to integrate aspects of human behavior to improve their performance. Recently developed models are not able to reproduce accurately trajectories that result from sudden avoidance maneuvers. Particularly, the human locomotion behavior when handling disturbances from other agents poses a problem. The goal of this work is to investigate whether humans alter their trajectory planning horizon, in order to resolve abruptly emerging collision situations. By modeling humans as model predictive controllers, the influence of the planning horizon is investigated in simulations. Based on these results, an experiment is designed to identify, whether humans initiate a change in their locomotion planning behavior while moving in a complex environment. The results support the hypothesis, that humans employ a shorter planning horizon to avoid collisions that are triggered by unexpected disturbances. Observations presented in this work are expected to further improve the generalizability and accuracy of prediction methods based on dynamic models. PMID:27936015

  20. New Horizons Imaging of Jupiter's Main Ring

    NASA Astrophysics Data System (ADS)

    Throop, Henry B.; Showalter, Mark Robert; Dones, Henry C. Luke; Hamilton, D. P.; Weaver, Harold A.; Cheng, Andrew F.; Stern, S. Alan; Young, Leslie; Olkin, Catherine B.; New Horizons Science Team

    2016-10-01

    New Horizons took roughly 520 visible-light images of Jupiter's ring system during its 2007 flyby, using the spacecraft's Long-Range Reconnaissance Imager (LORRI). These observations were taken over nine days surrounding Jupiter close-approach. They span a range in distance of 30 - 100 RJ, and a phase angle range of 20 - 174 degrees. The highest resolution images -- more than 200 frames -- were taken at a resolution approaching 20 km/pix.We will present an analysis of this dataset, much of which has not been studied in detail before. Our results include New Horizons' first quantitative measurements of the ring's intrinsic brightness and variability. We will also present results on the ring's azimuthal and radial structure. Our measurements of the ring's phase curve will be used to infer properties of the ring's dust grains.Our results build on the only previous analysis of the New Horizons Jupiter ring data set, presented in Showalter et al (2007, Science 318, 232-234), which detected ring clumps and placed a lower limit on the population of undetected ring-moons.This work was supported by NASA's OPR program.

  1. The Event Horizon of M87

    NASA Astrophysics Data System (ADS)

    Broderick, Avery E.; Narayan, Ramesh; Kormendy, John; Perlman, Eric S.; Rieke, Marcia J.; Doeleman, Sheperd S.

    2015-06-01

    The 6× {{10}9} {{M}⊙ } supermassive black hole at the center of the giant elliptical galaxy M87 powers a relativistic jet. Observations at millimeter wavelengths with the Event Horizon Telescope have localized the emission from the base of this jet to angular scales comparable to the putative black hole horizon. The jet might be powered directly by an accretion disk or by electromagnetic extraction of the rotational energy of the black hole. However, even the latter mechanism requires a confining thick accretion disk to maintain the required magnetic flux near the black hole. Therefore, regardless of the jet mechanism, the observed jet power in M87 implies a certain minimum mass accretion rate. If the central compact object in M87 were not a black hole but had a surface, this accretion would result in considerable thermal near-infrared and optical emission from the surface. Current flux limits on the nucleus of M87 strongly constrain any such surface emission. This rules out the presence of a surface and thereby provides indirect evidence for an event horizon.

  2. CaCl2, Bisoxazoline, and Malonate: A Protocol for an Asymmetric Michael Reaction.

    PubMed

    Lippur, Kristin; Kaabel, Sandra; Järving, Ivar; Rissanen, Kari; Kanger, Tõnis

    2015-06-19

    A mild protocol for the asymmetric Michael addition of dimethyl malonate to various α,β-unsaturated carbonyl compounds was developed. The salient feature of this methodology is that a cheap and environmentally friendly Lewis acid, CaCl2, was used as a catalyst. An aminoindanol- and pyridine-derived ligand provided in the presence of CaCl2 Michael adducts in moderate to high enantioselectivities. The scope of the reaction was demonstrated.

  3. Highly enantioselective Michael addition of nitroalkanes to chalcones using chiral squaramides as hydrogen bonding organocatalysts.

    PubMed

    Yang, Wen; Du, Da-Ming

    2010-12-03

    A series of squaramide-based organocatalysts were facilely synthesized and applied as hydrogen bonding organocatalysts in the enantioselective Michael addition of nitroalkanes to chalcones. These organocatalysts promoted the Michael addition with low catalyst loading under high temperature (80 °C), affording the desired R or S enantiomers of the products flexibly in high yields with excellent enantioselectivities (93-96% ee) by the appropriate choice of organocatalysts.

  4. Rationally designed multifunctional supramolecular iminium catalysis: direct vinylogous Michael addition of unmodified linear dienol substrates.

    PubMed

    Gu, Yun; Wang, Yao; Yu, Tian-Yang; Liang, Yong-Min; Xu, Peng-Fei

    2014-12-15

    The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long-standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to α,β-unsaturated aldehydes, to afford chiral 1,7-dioxo compounds with good yields and excellent regio- as well as enantioselectivity, has been developed.

  5. Asymmetric Michael Addition Induced by (R)-tert-Butanesulfinamide and Syntheses of Chiral Pyrazolidinone Derivatives.

    PubMed

    Huang, Hong-Xiu; Wang, Hui-Jing; Tan, Ling; Wang, Shu-Qing; Tang, Pei; Song, Hao; Liu, Xiao-Yu; Zhang, Dan; Qin, Yong

    2016-11-04

    A highly diastereoselective Michael addition of (R)-N-tert-butanesulfinyl imidates 8 to α,β-unsaturated pyrazolidinone 3a has been developed to afford pyrazolidinones 10 possessing three contiguous stereocenters with good to excellent yield and excellent diastereoselectivity. A two-step conversion of reduction and cyclization provides the bicyclic pyrazolopiperidine 12 in a good yield. A series of pyrazolopiperidine derivatives 18 with a quaternary carbon center at C-3a are stereoselectively synthesized via alkylation or Michael addition.

  6. L-prolinol as a highly enantioselective catalyst for Michael addition of cyclohexanone to nitroolefins.

    PubMed

    Chua, Pei Juan; Tan, Bin; Zeng, Xiaofei; Zhong, Guofu

    2009-07-15

    Though many chiral amines such as l-proline and its derivatives have proven to be versatile catalysts in many reactions, L-prolinol was seldom used as organocatalyst for reactions. Herein, we report the first L-prolinol catalyzed asymmetric Michael addition of cyclohexanone to nitroolefins in the presence of benzoic acid to afford Michael adducts with high diastereoselectivities (87:13->99:1) and enantioselectivities (82-96%).

  7. Asymmetric dearomatization of indoles through a Michael/Friedel-Crafts-type cascade to construct polycyclic spiroindolines.

    PubMed

    Zhao, Xiaohu; Liu, Xiaohua; Mei, Hongjiang; Guo, Jing; Lin, Lili; Feng, Xiaoming

    2015-03-23

    A highly efficient asymmetric dearomatization of indoles was realized through a cascade reaction between 2-isocyanoethylindole and alkylidene malonates catalyzed by a chiral N,N'-dioxide/Mg(II) catalyst. Fused polycyclic indolines containing three stereocenters were afforded in good yields with excellent diastereo- and enantioselectivities through a Michael/Friedel-Crafts/Mannich cascade. When 2-substituted 2-isocyanoethylindoles were used, spiroindoline derivatives were obtained through a Michael/Friedel-Crafts reaction.

  8. Pair production close to black hole horizon

    NASA Astrophysics Data System (ADS)

    Laurent, Philippe; Titarchuk, Lev

    2012-07-01

    Accreting stellar-mass black holes in Galactic binaries exhibit a ``bi-modal" spectral behavior - namely the so called high-soft and low-hard spectral states. An increase in the soft blackbody luminosity component leads to the appearance of an extended power law. An important observational fact is that this effect is seen as a persistent phenomenon only in BH candidates, and thus it is apparently a unique black hole signature. Although similar power law components are detected in the intermediate stages in neutron star systems, they are of a transient nature, i.e. disappearing with increasing luminosity. It thus seems a reasonable assumption that the unique spectral signature of the soft state of BH binaries is directly tied to the black hole event horizon. This is the primary motivation for the Bulk Motion Comptonization Model, introduced in several previous papers, and recently applied with striking success to a substantial body of observational data. We argued that the BH X-ray spectrum in the high-soft state is formed in the relatively cold accretion flow with a subrelativistic bulk velocity close to c and a temperature of a few keV. In such a flow the effect of the bulk Comptonization is indeed much stronger than the effect of the thermal ones. Another property of these accreted flow, that we will explore during this talk, is that, very close to horizon, X-ray photons may be upscattered by bulk electrons to MeV energy. Most of these photons fall down then in the black hole, but some of them anyway have time to interact with another X-ray photon by the photon-photon process to make an electron-positron pairs. We will then explore in details the consequences of this pair creation process close to horizon and what can be the observational evidences of this effect.

  9. Art, the Urban Skyscraper, and Horizon Astronomy

    NASA Astrophysics Data System (ADS)

    Mooney, J. D.

    2016-01-01

    This presentation delineates the historiography and the iconography of my urban public sculptures which use skyscrapers as today's standing stones, markers for horizon astronomy. From 1977 to the present time, my work has engaged the public to “look up and see.” Through ephemeral works in the sky and over the water to large-scale rooftop sculptures in Los Angeles, Chicago, Atlanta, and Europe, viewers are oriented to the Milky Way, the summer triangle, and other celestial phenomena. This new urban scale art, transformative in context and gesture, has become part of the new cultural landscape.

  10. Prolate horizons and the Penrose inequality

    SciTech Connect

    Tippett, Benjamin K.

    2009-05-15

    The Penrose inequality has so far been proven in cases of spherical symmetry and in cases of zero extrinsic curvature. The next simplest case worth exploring would be nonspherical, nonrotating black holes with nonzero extrinsic curvature. Following Karkowski et al.'s construction of prolate black holes, we define initial data on an asymptotically flat spacelike 3-surface with nonzero extrinsic curvature that may be chosen freely. This gives us the freedom to define the location of the apparent horizon such that the Penrose inequality is violated. We show that the dominant energy condition is violated at the poles for all cases considered.

  11. Peripheral Vision Horizon Display (PVHD). Corrected Copy

    NASA Technical Reports Server (NTRS)

    1984-01-01

    A Canadian invention, the peripheral vision horizon display (PVHD), shows promise in alleviating vertigo or disorientation in pilots flying under instrument conditions and easing the piloting task when flying in weather or other conditions requiring close attention to aircraft attitude instruments. A diversity of research and applied work was being done to investigate and validate the benefits of the PVHD during the years immediately preceding this conference. Organizers of the conference were able to assemble a group of outstanding presenters representing academic, industrial, and military. The theoretical foundation and applied use of the PVHD are discussed, and results from operational tests are presented.

  12. Time Horizon and Social Scale in Communication

    NASA Astrophysics Data System (ADS)

    Krantz, D. H.

    2010-12-01

    In 2009 our center (CRED) published a first version of The Psychology of Climate Change Communication. In it, we attempted to summarize facts and concepts from psychological research that could help guide communication. While this work focused on climate change, most of the ideas are at least partly applicable for communication about a variety of natural hazards. Of the many examples in this guide, I mention three. Single-action bias is the human tendency to stop considering further actions that might be needed to deal with a given hazard, once a single action has been taken. Another example is the importance of group affiliation in motivating voluntary contributions to joint action. A third concerns the finding that group participation enhances understanding of probabilistic concepts and promotes action in the face of uncertainty. One current research direction, which goes beyond those included in the above publication, focuses on how time horizons arise in the thinking of individuals and groups, and how these time horizons might influence hazard preparedness. On the one hand, individuals sometimes appear impatient, organizations look for immediate results, and officials fail to look beyond the next election cycle. Yet under some laboratory conditions and in some subcultures, a longer time horizon is adopted. We are interested in how time horizon is influenced by group identity and by the very architecture of planning and decision making. Institutional changes, involving long-term contractual relationships among communities, developers, insurers, and governments, could greatly increase resilience in the face of natural hazards. Communication about hazards, in the context of such long-term contractual relationships might look very different from communication that is first initiated by immediate threat. Another new direction concerns the social scale of institutions and of communication about hazards. Traditionally, insurance contracts share risk among a large

  13. New horizons mapping of Europa and Ganymede.

    PubMed

    Grundy, W M; Buratti, B J; Cheng, A F; Emery, J P; Lunsford, A; McKinnon, W B; Moore, J M; Newman, S F; Olkin, C B; Reuter, D C; Schenk, P M; Spencer, J R; Stern, S A; Throop, H B; Weaver, H A

    2007-10-12

    The New Horizons spacecraft observed Jupiter's icy satellites Europa and Ganymede during its flyby in February and March 2007 at visible and infrared wavelengths. Infrared spectral images map H2O ice absorption and hydrated contaminants, bolstering the case for an exogenous source of Europa's "non-ice" surface material and filling large gaps in compositional maps of Ganymede's Jupiter-facing hemisphere. Visual wavelength images of Europa extend knowledge of its global pattern of arcuate troughs and show that its surface scatters light more isotropically than other icy satellites.

  14. An uneventful horizon in two dimensions

    NASA Astrophysics Data System (ADS)

    Almheiri, Ahmed; Sully, James

    2014-02-01

    We investigate the possibility of firewalls in the Einstein-dilaton gravity model of CGHS. We use the results of the numerical simulation carried out by Ashtekar et al. to demonstrate that firewalls are absent and the horizon is drama free. We show that the lack of a firewall is consistent because the model does not satisfy one of the postulates of black hole complementarity. In particular, we elaborate on previous work showing that the Hawking radiation is not pure, and is completely entangled with a long-lived remnant beyond the last ray.

  15. Redshift of a photon emitted along the black hole horizon

    NASA Astrophysics Data System (ADS)

    Toporensky, A. V.; Zaslavskii, O. B.

    2017-03-01

    In this work we derive some general features of the redshift measured by radially moving observers in the black hole background. Let observer 1 cross the black hole horizon emitting a photon, while observer 2 crossing the same horizon later receives it. We show that if (i) the horizon is the outer one (event horizon) and (ii) it is nonextremal, the received frequency is redshifted. This generalizes recent results in the literature. For the inner horizon (like in the Reissner-Nordström metric) the frequency is blueshifted. If the horizon is extremal, the frequency does not change. We derive explicit formulas describing the frequency shift in generalized Kruskal- and Lemaitre-like coordinates.

  16. New Horizons. A National Workplace Literacy Program. Final Report. "New Horizons" External Evaluation Impact Study.

    ERIC Educational Resources Information Center

    Hudson, Patt; Gretes, John A.

    The New Horizons project was a workplace literacy partnership during which 454 employees (53%) of Georgetown Steel attended classes provided by Horry-Georgetown Technical College in Conway, South Carolina. Of the 454 participants, 294 were white, 159 were black, 71 were female, 383 were male, 133 had been with the company for 5 years or less, and…

  17. Dynamical horizons: energy, angular momentum, fluxes, and balance laws.

    PubMed

    Ashtekar, Abhay; Krishnan, Badri

    2002-12-23

    Dynamical horizons are considered in full, nonlinear general relativity. Expressions of fluxes of energy and angular momentum carried by gravitational waves across these horizons are obtained. Fluxes are local, the energy flux is positive, and change in the horizon area is related to these fluxes. The flux formulas also give rise to balance laws analogous to the ones obtained by Bondi and Sachs at null infinity and provide generalizations of the first and second laws of black-hole mechanics.

  18. Radiation from quantum weakly dynamical horizons in loop quantum gravity.

    PubMed

    Pranzetti, Daniele

    2012-07-06

    We provide a statistical mechanical analysis of quantum horizons near equilibrium in the grand canonical ensemble. By matching the description of the nonequilibrium phase in terms of weakly dynamical horizons with a local statistical framework, we implement loop quantum gravity dynamics near the boundary. The resulting radiation process provides a quantum gravity description of the horizon evaporation. For large black holes, the spectrum we derive presents a discrete structure which could be potentially observable.

  19. TUTORIAL ON NETWORK GENOMICS.

    SciTech Connect

    Forst, C.

    2001-01-01

    With the ever-increasing genomic information pouring into the databases researchers start to look for pattern in genomes. Key questions are the identification of function. In the past function was mainly understood to be assigned to a single gene isolated from other cellular components or mechanisms. Sequence comparison fo single genes and their products (proteins) as well as of intergenic space are a consequence of a well established one-gene one-function interpretation. prediction of function solely by sequence similarity searches are powerful techniques that initiated the advent of bioinformatics and computational biology. Seminal work on sequence alignment by Temple Smith and Michael Waterman [33] and sequence searches with the BLAST algorithm by Altschul et al. [2] provide essential methods for sequence based determination of function. Similar outstanding contributions to determination of function have been archived in the area of structure prediction, molecular modeling and molecular dynamics. Techniques covering ab initio and homology modeling up to biophysical interpretation of long-run molecular dynamics simulations are mentioned ehre. With the ever-increasing number of information of different genetic/genomic origin, new aspect are looked for that deviate from the single gene at a time method. Especially with the identification of surprisingly few human genes the emerging perception in the scientific community that the concept of function has to be extended to include other sequence based as well as non-sequenced based information. A schema of determination of function by different concepts is shown in Figure 1. The tutorial is comprised of the following sections: The first two sections discuss the differences between genomic and non-genomic based context information, section three will cover combined methods. Finally, section four lsits web-resources and databases. All presented approaches extensively employ comparative methods.

  20. Gravitational anomaly and Hawking radiation near a weakly isolated horizon

    SciTech Connect

    Wu Xiaoning; Huang Chaoguang; Sun Jiarui

    2008-06-15

    Based on the idea of the work by Wilczek and his collaborators, we consider the gravitational anomaly near a weakly isolated horizon. We find that there exists a universal choice of tortoise coordinate for any weakly isolated horizon. Under this coordinate, the leading behavior of a quite arbitrary scalar field near a horizon is a 2-dimensional chiral scalar field. This means we can extend the idea of Wilczek and his collaborators to more general cases and show the relation between gravitational anomaly and Hawking radiation is a universal property of a black hole horizon.

  1. Gravitational anomaly and Hawking radiation near a weakly isolated horizon

    NASA Astrophysics Data System (ADS)

    Wu, Xiaoning; Huang, Chao-Guang; Sun, Jia-Rui

    2008-06-01

    Based on the idea of the work by Wilczek and his collaborators, we consider the gravitational anomaly near a weakly isolated horizon. We find that there exists a universal choice of tortoise coordinate for any weakly isolated horizon. Under this coordinate, the leading behavior of a quite arbitrary scalar field near a horizon is a 2-dimensional chiral scalar field. This means we can extend the idea of Wilczek and his collaborators to more general cases and show the relation between gravitational anomaly and Hawking radiation is a universal property of a black hole horizon.

  2. Into the Kuiper Belt: New Horizons Post-Pluto

    NASA Astrophysics Data System (ADS)

    Harrison Parker, Alex; Spencer, John; Benecchi, Susan; Binzel, Richard; Borncamp, David; Buie, Marc; Fuentes, Cesar; Gwyn, Stephen; Kavelaars, JJ; Noll, Keith; Petit, Jean-Marc; Porter, Simon; Showalter, Mark; Stern, S. Alan; Sterner, Ray; Tholen, David; Verbiscer, Anne; Weaver, Hal; Zangari, Amanda

    2015-11-01

    New Horizons is now beyond Pluto and flying deeper into the Kuiper Belt. In the summer of 2014, a Hubble Space Telescope Large Program identified two candidate Cold Classical Kuiper Belt Objects (KBOs) that were within reach of New Horizons' remaining fuel budget. Here we present the selection of the Kuiper Belt flyby target for New Horizons' post-Pluto mission, our state of knowledge regarding this target and the potential 2019 flyby, the status of New Horizons' targeting maneuver, and prospects for near-future long-range observations of other KBOs.

  3. Criticality and surface tension in rotating horizon thermodynamics

    NASA Astrophysics Data System (ADS)

    Hansen, Devin; Kubizňák, David; Mann, Robert B.

    2016-08-01

    We study a modified horizon thermodynamics and the associated criticality for rotating black hole spacetimes. Namely, we show that under a virtual displacement of the black hole horizon accompanied by an independent variation of the rotation parameter, the radial Einstein equation takes a form of a ‘cohomogeneity two’ horizon first law, δ E=Tδ S+{{Ω }}δ J-σ δ A, where E and J are the horizon energy (an analogue of the Misner-Sharp mass) and the horizon angular momentum, Ω is the horizon angular velocity, A is the horizon area, and σ is the surface tension induced by the matter fields. For fixed angular momentum, the above equation simplifies and the more familiar (cohomogeneity one) horizon first law δ E=Tδ S-Pδ V is obtained, where P is the pressure of matter fields and V is the horizon volume. A universal equation of state is obtained in each case and the corresponding critical behavior is studied.

  4. Numerical examination of an evolving black string horizon

    NASA Astrophysics Data System (ADS)

    Garfinkle, David; Lehner, Luis; Pretorius, Frans

    2005-03-01

    We use the numerical solution describing the evolution of a perturbed black string presented by M. Choptuik, L. Lehner, I. Olabarrieta, R. Petryk, F. Pretorius, and H. Villegas [Phys. Rev. D 68, 044001 (2003)] to elucidate the intrinsic behavior of the horizon. It is found that by the end of the simulation, the affine parameter on the horizon has become very large and the expansion and shear of the horizon in turn very small. This suggests the possibility that the horizon might pinch off in infinite affine parameter.

  5. Isolated and dynamical horizons from a common perspective

    SciTech Connect

    Korzynski, Mikolaj

    2006-11-15

    A framework is developed in which one can write down the constraint equations on a three-dimensional hypersurface of arbitrary signature. It is then applied to isolated and dynamical horizons. The derived equations can be used to extract physically relevant quantities describing the horizon irrespective to whether it is isolated (null) or dynamical at a given instant of time. Furthermore, a small perturbation of isolated horizons are considered, and finally a family of an axially symmetric exact solution of the constraint equations on a dynamical horizon is presented.

  6. Horizons versus singularities in spherically symmetric space-times

    SciTech Connect

    Bronnikov, K. A.; Elizalde, E.; Odintsov, S. D.; Zaslavskii, O. B.

    2008-09-15

    We discuss different kinds of Killing horizons possible in static, spherically symmetric configurations and recently classified as 'usual', 'naked', and 'truly naked' ones depending on the near-horizon behavior of transverse tidal forces acting on an extended body. We obtain the necessary conditions for the metric to be extensible beyond a horizon in terms of an arbitrary radial coordinate and show that all truly naked horizons, as well as many of those previously characterized as naked and even usual ones, do not admit an extension and therefore must be considered as singularities. Some examples are given, showing which kinds of matter are able to create specific space-times with different kinds of horizons, including truly naked ones. Among them are fluids with negative pressure and scalar fields with a particular behavior of the potential. We also discuss horizons and singularities in Kantowski-Sachs spherically symmetric cosmologies and present horizon regularity conditions in terms of an arbitrary time coordinate and proper (synchronous) time. It turns out that horizons of orders 2 and higher occur in infinite proper times in the past or future, but one-way communication with regions beyond such horizons is still possible.

  7. Energy and information near black hole horizons

    SciTech Connect

    Freivogel, Ben

    2014-07-01

    The central challenge in trying to resolve the firewall paradox is to identify excitations in the near-horizon zone of a black hole that can carry information without injuring a freely falling observer. By analyzing the problem from the point of view of a freely falling observer, I arrive at a simple proposal for the degrees of freedom that carry information out of the black hole. An infalling observer experiences the information-carrying modes as ingoing, negative energy excitations of the quantum fields. In these states, freely falling observers who fall in from infinity do not encounter a firewall, but freely falling observers who begin their free fall from a location close to the horizon are ''frozen'' by a flux of negative energy. When the black hole is ''mined,'' the number of information-carrying modes increases, increasing the negative energy flux in the infalling frame without violating the equivalence principle. Finally, I point out a loophole in recent arguments that an infalling observer must detect a violation of unitarity, effective field theory, or free infall.

  8. THE EVENT HORIZON OF SAGITTARIUS A*

    SciTech Connect

    Broderick, Avery E.; Loeb, Abraham; Narayan, Ramesh

    2009-08-20

    Black hole event horizons, causally separating the external universe from compact regions of spacetime, are one of the most exotic predictions of general relativity. Until recently, their compact size has prevented efforts to study them directly. Here we show that recent millimeter and infrared observations of Sagittarius A* (Sgr A*), the supermassive black hole at the center of the Milky Way, all but require the existence of a horizon. Specifically, we show that these observations limit the luminosity of any putative visible compact emitting region to below 0.4% of Sgr A*'s accretion luminosity. Equivalently, this requires the efficiency of converting the gravitational binding energy liberated during accretion into radiation and kinetic outflows to be greater than 99.6%, considerably larger than those implicated in Sgr A*, and therefore inconsistent with the existence of such a visible region. Finally, since we are able to frame this argument entirely in terms of observable quantities, our results apply to all geometric theories of gravity that admit stationary solutions, including the commonly discussed f(R) class of theories.

  9. Near-horizon brane-scan revived

    NASA Astrophysics Data System (ADS)

    Duff, M. J.

    2009-03-01

    In 1987 two versions of the brane-scan of D-dimensional super p-branes were put forward. The first pinpointed those (p,D) slots consistent with kappa-symmetric Green-Schwarz type actions; the second generalized the membrane at the end of the universe idea to all those superconformal groups describing p-branes on the boundary of AdS×S. Although the second version predicted D3- and M5-branes in addition to those of the first, it came unstuck because the 1/2 BPS solitonic branes failed to exhibit the required symmetry enhancement in the near-horizon limit, except in the non-dilatonic cases (p=2,D=11), (p=3,D=10) and (p=5,D=11). Just recently, however, it has been argued that the fundamental D=10 heterotic string does indeed display a near-horizon enhancement to OSp(8|2) as predicted by the brane-scan, provided α corrections are taken into account. If this logic could be extended to the other strings and branes, it would resolve this 21-year-old paradox and provide a wealth of new AdS/CFT dualities, which we tabulate.

  10. 50 Years of Soil Survey Horizons

    NASA Astrophysics Data System (ADS)

    Brevik, E. C.

    2012-04-01

    Soil Survey Horizons (SSH) started in 1960 as the newsletter of the North Central Soil Survey, United States, with an editorial board consisting of Francis D. Hole, O.C. Rogers, and Donald F. Post. SSH was started to provide an outlet for field observations of soils because the founders of SSH felt that other outlets for such communications were disappearing. Francis Hole's office at the University of Wisconsin served as the point of publication for SSH through its first 15 years, but in 1975 the Soil Science Society of America (SSSA) began handling its publication. Initially SSSA published SSH but did not assume ownership or editorial control of the publication until 2005. Over the years there has been a steady increase in the amount of material published in each volume of SSH. Significant improvements to Soil Survey Horizons over the years have included a move to full 8.5" x 11" pages and publication in color. Future improvements will include online publication and expansion to an international audience, including recruitement of international members for the editorial board.

  11. Status of the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Fish, Vincent L.; Doeleman, S. S.; Event Horizon Telescope Collaboration

    2011-05-01

    The goal of the Event Horizon Telescope (EHT) project is to understand the physical and astrophysical processes of supermassive black holes though extremely high angular resolution observations. The EHT consists of existing millimeter-wavelength telescopes that participate in very long baseline interferometry (VLBI) observations of Sagittarius A*, M87, and active galactic nuclei. For the nearest sources, the EHT is uniquely capable of providing a resolution of a few Schwarzschild radii. Prior EHT observations have demonstrated very compact structure in Sgr A* and have been used to constrain the orientation of the black hole spin vector, strengthen the case for the existence of an event horizon, and examine the spatial characteristics of the variable millimeter emission. The sensitivity and angular resolution of the array are increasing due to the inclusion of new telescopes and several technical developments currently underway. We will summarize the most recent observations as well as the outlook for further enhancements of the capabilities of the EHT in the near future. This work is funded by grants from the National Science Foundation.

  12. Oil sheen weathering post Deepwater Horizon

    NASA Astrophysics Data System (ADS)

    Kellermann, M. Y.; Redmond, M. C.; Reddy, C. M.; Aeppli, C.; Nelson, R. K.; Valentine, D. L.

    2013-12-01

    A recently published study identified the source of the reoccurred oil sheens close to the Deepwater Horizon (DWH) disaster site as a finite contamination most likely derived from tanks and pits on the DWH wreckage itself. Here we use geochemical fingerprinting and microbial community analysis to better understand the fate and weathering processes affecting these surface oils. Both, alkanes and polycyclic aromatic hydrocarbons (PAHs) are shown to reflect a linear decrease of hydrocarbon compounds with increasing distance to the DWH wreckage site (equivalent to exposure time on the sea surface). These results indicate that in the early stage of weathering the combined effects of dissolution and evaporation dominate the degradation of these surface oils. Sheen microbial communities were dominated by Cyanobacteria, Planctomycetes, Verrucomicrobia, Flavobacteria, Alphaproteobacteria, and Deltaproteobacteria, with low relative abundances of Gammaproteobacteria likely to be hydrocarbon degraders (no more than 15% of sequences in each sample). However, some of these Gammaproteobacteria were closely related to putative hydrocarbon degraders observed in abundance in deep water plumes during the primary Deepwater Horizon spill, suggesting that very low levels of biodegradation may be also occurring. This in situ weathering experiment provides new insights in hydrocarbon weathering dynamics and shows how chemical and biological changes can potentially be masked by large evaporative losses of compounds smaller than C18 n-alkanes.

  13. Cool horizons lead to information loss

    NASA Astrophysics Data System (ADS)

    Chowdhury, Borun D.

    2013-10-01

    There are two evidences for information loss during black hole evaporation: (i) a pure state evolves to a mixed state and (ii) the map from the initial state to final state is non-invertible. Any proposed resolution of the information paradox must address both these issues. The firewall argument focuses only on the first and this leads to order one deviations from the Unruh vacuum for maximally entangled black holes. The nature of the argument does not extend to black holes in pure states. It was shown by Avery, Puhm and the author that requiring the initial state to final state map to be invertible mandates structure at the horizon even for pure states. The proof works if black holes can be formed in generic states and in this paper we show that this is indeed the case. We also demonstrate how models proposed by Susskind, Papadodimas et al. and Maldacena et al. end up making the initial to final state map non-invertible and thus make the horizon "cool" at the cost of unitarity.

  14. Energy and information near black hole horizons

    NASA Astrophysics Data System (ADS)

    Freivogel, Ben

    2014-07-01

    The central challenge in trying to resolve the firewall paradox is to identify excitations in the near-horizon zone of a black hole that can carry information without injuring a freely falling observer. By analyzing the problem from the point of view of a freely falling observer, I arrive at a simple proposal for the degrees of freedom that carry information out of the black hole. An infalling observer experiences the information-carrying modes as ingoing, negative energy excitations of the quantum fields. In these states, freely falling observers who fall in from infinity do not encounter a firewall, but freely falling observers who begin their free fall from a location close to the horizon are ``frozen'' by a flux of negative energy. When the black hole is ``mined,'' the number of information-carrying modes increases, increasing the negative energy flux in the infalling frame without violating the equivalence principle. Finally, I point out a loophole in recent arguments that an infalling observer must detect a violation of unitarity, effective field theory, or free infall.

  15. Formal Synthesis of (+)-Lasubine II and (-)-Subcosine II via Organocatalytic Michael Addition of a Ketone to an α-Nitrostyrene.

    PubMed

    N V G, Moorthy; Dyapa, Rajendar; Pansare, Sunil V

    2015-11-06

    The first examples of an organocatalytic Michael addition of a ketone to in situ generated α-nitrostyrenes are reported. A suitably functionalized γ-nitroketone obtained from the organocatalyzed Michael addition was converted into (+)-2-epi-lasubine II, the immediate synthetic precursor of (+)-lasubine II and (-)-subcosine II (enantiomers of the natural quinolizidine alkaloids). Two of the three stereocenters in (+)-2-epi-lasubine II are set by the Michael reaction.

  16. X-24B with Test Pilot Michael V. Love

    NASA Technical Reports Server (NTRS)

    1973-01-01

    This photo shows Air Force Lieutenant Colonel Michael V. Love in front of the X-24B lifting-body research vehicle at Edwards Air Force Base in 1973. Love was assigned as a project pilot on the joint NASA-USAF X-24B Lifting Body flight test program at the NASA Flight Research Center. He made a total of 12 flights in the plane from October 4, 1973 until July 15, 1975. Love flew it to a speed of Mach 1.76 on October 25, 1974, a record for the X-24B. Love attended the USAF Test Pilot School and remained as an instructor there from 1969 through 1971. He was a test pilot at Edwards when assigned to fly to the X-24B. Love was a combat veteran of Vietnam and was awarded the Distinguished Flying Cross with two Oak Leaf clusters. Love perished while attempting an emergency landing in an RF-4C on March 1, 1976. The X-24B was the last aircraft to fly in the Dryden Flight Research Center's manned lifting body program. The X-24 was one of a group of lifting bodies flown by the NASA Flight Research Center (now Dryden Flight Research Center), Edwards, California, in a joint program with the U.S. Air Force at Edwards Air Force Base from 1963 to 1975. The lifting bodies were used to demonstrate the ability of pilots to maneuver and safely land wingless vehicles designed to fly back to Earth from space and be landed like an airplane at a predetermined site. Lifting bodies' aerodynamic lift, essential to flight in the atmosphere, was obtained from their shape. The addition of fins and control surfaces allowed the pilots to stabilize and control the vehicles and regulate their flight paths. Built by Martin Aircraft Company, Maryland, for the U.S. Air Force, the X-24A was a bulbous vehicle shaped like a teardrop with three vertical fins at the rear for directional control. It weighed 6,270 pounds, was 24.5 feet long and 11.5 feet wide (measuring just the fuselage, not the distance between the tips of the outboard fins). Its first unpowered glide flight was on April 17, 1969, with Air

  17. In Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.

    PubMed

    Duplan, Vincent; Hoshino, Manabu; Li, Wei; Honda, Tadashi; Fujita, Makoto

    2016-04-11

    A reversible Michael addition reaction between thiol nucleophiles and cyanoenones has been previously postulated to be the mechanism-of-action of a new family of reversible covalent drugs. However, the hypothetical Michael adducts in this mechanism have only been detected by spectroscopic methods in solution. Herein, the crystallographic observation of reversible Michael addition with a potent cyanoenone drug candidate by means of the crystalline-sponge method is reported. After inclusion of the cyanoenone substrate, the sponge crystal was treated with a thiol solution. Subsequent crystallographic analysis confirmed the single-crystal-to-single-crystal transformation of the substrate into the impermanent Michael adduct.

  18. A general overview of the organocatalytic intramolecular aza-Michael reaction.

    PubMed

    Sánchez-Roselló, María; Aceña, José Luis; Simón-Fuentes, Antonio; del Pozo, Carlos

    2014-11-07

    The organocatalytic intramolecular aza-Michael reaction gives access to enantiomerically enriched nitrogen-containing heterocycles in a very simple manner. Enals, enones, conjugated esters and nitro olefins have been employed as Michael acceptors, while moderate nitrogen nucleophiles such as sulphonamides, carbamates and amides have been shown to be appropriate Michael donors in this type of reaction. Additionally, the process has been performed under both covalent and non-covalent catalysis, with diaryl prolinols, imidazolidinones, thioureas and chiral binol phosphoric acids being the most frequently used catalysts. The level of efficiency reached with this protocol is demonstrated by the implementation of numerous tandem processes, as well as the total synthesis of several natural products.

  19. Empirical correction for earth sensor horizon radiance variation

    NASA Technical Reports Server (NTRS)

    Hashmall, Joseph A.; Sedlak, Joseph; Andrews, Daniel; Luquette, Richard

    1998-01-01

    A major limitation on the use of infrared horizon sensors for attitude determination is the variability of the height of the infrared Earth horizon. This variation includes a climatological component and a stochastic component of approximately equal importance. The climatological component shows regular variation with season and latitude. Models based on historical measurements have been used to compensate for these systematic changes. The stochastic component is analogous to tropospheric weather. It can cause extreme, localized changes that for a period of days, overwhelm the climatological variation. An algorithm has been developed to compensate partially for the climatological variation of horizon height and at least to mitigate the stochastic variation. This method uses attitude and horizon sensor data from spacecraft to update a horizon height history as a function of latitude. For spacecraft that depend on horizon sensors for their attitudes (such as the Total Ozone Mapping Spectrometer-Earth Probe-TOMS-EP) a batch least squares attitude determination system is used. It is assumed that minimizing the average sensor residual throughout a full orbit of data results in attitudes that are nearly independent of local horizon height variations. The method depends on the additional assumption that the mean horizon height over all latitudes is approximately independent of season. Using these assumptions, the method yields the latitude dependent portion of local horizon height variations. This paper describes the algorithm used to generate an empirical horizon height. Ideally, an international horizon height database could be established that would rapidly merge data from various spacecraft to provide timely corrections that could be used by all.

  20. Michael addition reactions for the modification of gold nanoparticles facilitated by hyperbaric conditions.

    PubMed

    Hartlen, Kurtis D; Ismaili, Hossein; Zhu, Jun; Workentin, Mark S

    2012-01-10

    The chemical interfacial modification of organic solvent soluble 2.4 ± 0.5 nm maleimide-modified monolayer protected gold nanoparticles (2-C(12)AuNPs) with primary or secondary amines via Michael addition reactions is demonstrated. Michael addition reactions between 2-C(12)AuNPs and primary or secondary amines at ambient temperature and pressure and under the conditions where the AuNP is soluble and stable are possible albeit sluggish, often taking days to weeks to go to completion. The rates and efficacies of the these same reactions are drastically increased at hyperbaric pressure conditions (11 000 atm) with no observed adverse effect to the gold nanoparticle stability. The resulting Michael addition adducts (3-C(12)AuNPs) formed from 2-C(12)AuNPs and the corresponding amines were characterized by TEM and by comparison of the (1)H NMR spectra of the 3-C(12)AuNPs with those of model reactions of the same amines with N-dodecylmaleimide, 2. The Michael addition reactions occur more readily with 2 rather than 2-C(12)AuNPs, consistent with the local environment of the latter imposing additional steric or other barriers to the reaction. The use of hyperbaric conditions makes the reaction of the organic solvent soluble 2-C(12)AuNP via Michael addition a viable interfacial modification process that is otherwise impractical. The results also suggest that it is a useful protocol for facilitating Michael addition reactions generally in solution at low temperatures.

  1. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors.

    PubMed

    Schmid, Thibault E; Drissi-Amraoui, Sammy; Crévisy, Christophe; Baslé, Olivier; Mauduit, Marc

    2015-01-01

    The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field.

  2. Aza-Michael Mono-addition Using Acidic Alumina under Solventless Conditions.

    PubMed

    Bosica, Giovanna; Abdilla, Roderick

    2016-06-22

    Aza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.

  3. Organocatalytic regioselective asymmetric Michael addition of azlactones to o-hydroxy chalcone derivatives.

    PubMed

    Zhang, Shao-Yun; Ruan, Gui-Yu; Geng, Zhi-Cong; Li, Nai-Kai; Lv, Ming; Wang, Yong; Wang, Xing-Wang

    2015-05-28

    The regioselective and enantioselective Michael addition between azlactones and o-hydroxy chalcone derivatives is reported. Enantiomerically enriched N,O-aminals with two continuous stereogenic centers are exclusively obtained in moderate to good yields with excellent diastereoselectivities and good to excellent enantioselectivities. The experimental results show that an o-hydroxy group on the cinnamenyl motif of chalcone derivatives plays a crucial role at the reaction sites for the regioselective Michael addition. In addition, circular dichroism (CD) spectroscopy and density functional theory (DFT) are used to investigate the absolute configuration of N,O-aminals and the corresponding transition-state structures.

  4. Asymmetric Synthesis of Octahydroindoles via a Domino Robinson Annulation/5-Endo Intramolecular Aza-Michael Reaction.

    PubMed

    Parra, Claudio; Bosch, Caroline; Gómez-Bengoa, Enrique; Bonjoch, Josep; Bradshaw, Ben

    2016-11-04

    A straightforward, two-step asymmetric synthesis of octahydroindoles has been developed on the basis of two complementary strategies: (i) an organocatalyzed Michael reaction followed by a tandem Robinson-aza-Michael double cyclization catalyzed by PS-BEMP, and (ii) a diastereoselective cyclization, which formally constitutes a remote 1,6 asymmetric induction mediated by PS-BEMP. This allowed the construction of complex octahydroindoles with up to four stereocenters, excellent enantioselectivities (up to 95% ee), and complete diastereoselective control in a single-pot operation. DFT calculations were performed to understand the origin of this effect.

  5. Photodynamic therapy in dermatology: history and horizons.

    PubMed

    Taub, Amy Forman

    2004-01-01

    Photodynamic therapy (PDT) uses a photosensitizer, light, and molecular oxygen to selectively kill cells. When localized in the target tissue, the photosensitizer is activated by light to produce oxygen intermediates that destroy target tissue cells. The easy access of skin to light-based therapy has led dermatologists to apply PDT to cutaneous disorders. In dermatology, PDT has been most successful in treating actinic keratoses, basal cell carcinoma, and Bowen's disease. The introduction of aminolevulinic acid, which does not make patients susceptible to phototoxicity for extended periods, has reduced morbidity associated with PDT. This has led to new interest in PDT not only for nonmelanoma skin cancer and premalignant lesions but also in the treatment of acne and as an adjuvant to photorejuvenation procedures. This review examines the historical roots of PDT and the research evaluating different light and laser sources as well as reports on new horizons for PDT in dermatology.

  6. Horizon complementarity in elliptic de Sitter space

    NASA Astrophysics Data System (ADS)

    Hackl, Lucas; Neiman, Yasha

    2015-02-01

    We study a quantum field in elliptic de Sitter space dS4/Z2—the spacetime obtained from identifying antipodal points in dS4. We find that the operator algebra and Hilbert space cannot be defined for the entire space, but only for observable causal patches. This makes the system into an explicit realization of the horizon complementarity principle. In the absence of a global quantum theory, we propose a recipe for translating operators and states between observers. This translation involves information loss, in accordance with the fact that two observers see different patches of the spacetime. As a check, we recover the thermal state at the de Sitter temperature as a state that appears the same to all observers. This thermal state arises from the same functional that, in ordinary dS4, describes the Bunch-Davies vacuum.

  7. Black Hole Observations - Towards the Event Horizon

    NASA Astrophysics Data System (ADS)

    Britzen, Silke

    Black Holes are probably the most elusive solutions of Einstein's theory of General Relativity. Despite numerous observations of the direct galactic environment and indirect influence of astrophysical black holes (e.g. jets, variable emission across the wavelength spectrum, feedback processes, etc.) -- a direct proof of their existence is still lacking. This article highlights some aspects deduced from many observations and concentrates on the experimental results with regard to black holes with masses from millions to billions of solar masses. The focus will be on the challenges and remaining questions. The Event Horizon Telescopce (EHT) project to image the photon sphere of Sgr A* and its potential is briefly sketched. This instrumental approach shall lead to highest resolution observations of the supermassive black hole at the center of the Milky Way (Sgr A*).

  8. The NMC Horizon Report: 2014 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2014-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within every sector of education in some 65…

  9. Submesoscale Dispersion in the Vicinity of the Deepwater Horizon Spill

    DTIC Science & Technology

    2014-09-02

    ecosystems, society, and the economy as evidenced by the Deepwater Horizon oil spill in the Gulf of Mexico in 2010 and the Fukushima nuclear plant...evidenced by the Deepwater Horizon oil spill in the Gulf of Mexico in 2010 and the Fukushima nuclear plant incident in the Pacific Ocean in 2011. Accurate

  10. NEW JERSEY APPROACH TO OUTERBRIDGE CROSSING BRIDGE, NOTE DISTANT HORIZON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NEW JERSEY APPROACH TO OUTERBRIDGE CROSSING BRIDGE, NOTE DISTANT HORIZON NEW YORK SKYLINE AND ALMOST IN THE MIDDLE OF THE HORIZON THE TWIN TOWERS OF THE VERRAZANO-NARROWS BRIDGE - Outerbridge Crossing Bridge, Spanning Arthur Kill from New Jersey to Staten Island, Staten Island (subdivision), Richmond County, NY

  11. Near-horizon conformal symmetry and black hole entropy.

    PubMed

    Carlip, S

    2002-06-17

    Near an event horizon, the action of general relativity acquires a new asymptotic conformal symmetry. For two-dimensional dilaton gravity, this symmetry results in a chiral Virasoro algebra, and Cardy's formula for the density of states reproduces the Bekenstein-Hawking entropy. This lends support to the notion that black hole entropy is controlled universally by conformal symmetry near the horizon.

  12. The NMC Horizon Report: 2015 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The "NMC Horizon Report: 2015 Higher Education Edition" is a collaborative effort between the New Media Consortium (NMC) and the EDUCAUSE Learning Initiative (ELI). This 12th edition describes annual findings from the NMC Horizon Project, an ongoing research project designed to identify and describe emerging technologies likely to have…

  13. Comparing Three Jet Rates with and without Hadronic Rindler Horizon

    NASA Astrophysics Data System (ADS)

    Ghaffary, Tooraj

    2017-03-01

    Recently, some researchers, (Sepehri and Shoorvazi Chin. Phys. Lett. 30(2), 021301, [2013]), have considered the effect of Rindler horizon on three jet rate. This paper confirms their results and by comparing usual models with this new model for different energies, shows that regarding Rindler horizon gives us the results which more close to experimental data respect to usual models.

  14. New Horizons Risk Communication Strategy, Planning, Implementation, and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Dawson, Sandra A.

    2006-01-01

    This paper discusses the risk communication goals, strategy, planning process and product development for the New Horizons mission, including lessons from the Cassini mission that were applied in that effort, and presents lessons learned from the New Horizons effort that could be applicable to future missions.

  15. The NMC Horizon Report: 2011 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams, S.; Haywood, K.

    2011-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium. (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This volume, "The…

  16. The NMC Horizon Report: 2013 K-12 Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Cummins, M.; Estrada V.; Freeman, A.; Ludgate, H.

    2013-01-01

    "The NMC Horizon Report" series is the most visible outcome of the New Media Consortium (NMC) Horizon Project, an ongoing research effort established in 2002 that identifies and describes emerging technologies likely to have a large impact on teaching, learning, research, or creative expression within education around the globe. This…

  17. A Fusion of Horizons: Students' Encounters with "Will and Wave"

    ERIC Educational Resources Information Center

    Myers, James L.

    2006-01-01

    In a case study, I applied philosophical hermeneutic principles in an advanced level EFL writing class in Taiwan. A "fusion of horizons" occurs at the junction of two intertwined interpretations: one from our socio-historical tradition and the other from our experience of novel phenomena. I explored students' hermeneutic horizons in…

  18. The Horizon Report: 2009 Australia-New Zealand Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Levine, A.; Smith, R.; Smythe, T.; Stone, S.

    2009-01-01

    The New Media Consortium's Horizon Project is an ongoing research project that aims to identify and describe emerging technologies likely to have a large impact on teaching, learning, or creative inquiry within education around the globe over a five-year time period. The project's central products are the "Horizon Reports", an annual…

  19. The NMC Horizon Report: 2012 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams, S.; Cummins, M.

    2012-01-01

    The internationally recognized "NMC Horizon Report" series and regional "NMC Technology Outlooks" are part of the NMC Horizon Project, a comprehensive research venture established in 2002 that identifies and describes emerging technologies likely to have a large impact over the coming five years in education around the globe. This volume, the "NMC…

  20. THERMAL CONDUCTIVITY OF THE POTENTIAL REPOSITORY HORIZON

    SciTech Connect

    J.E. BEAN

    2004-09-27

    The primary purpose of this report is to assess the spatial variability and uncertainty of bulk thermal conductivity in the host horizon for the repository at Yucca Mountain. More specifically, the lithostratigraphic units studied are located within the Topopah Spring Tuff (Tpt) and consist of the upper lithophysal zone (Tptpul), the middle nonlithophysal zone (Tptpmn), the lower lithophysal zone (Tptpll), and the lower nonlithophysal zone (Tptpln). Design plans indicate that approximately 81 percent of the repository will be excavated in the Tptpll, approximately 12 percent in the Tptpmn, and the remainder in the Tptul and Tptpln (BSC 2004 [DIRS 168370]). This report provides three-dimensional geostatistical estimates of the bulk thermal conductivity for the four stratigraphic layers of the repository horizon. The three-dimensional geostatistical estimates of matrix and lithophysal porosity, dry bulk density, and matrix thermal conductivity are also provided. This report provides input to various models and calculations that simulate heat transport through the rock mass. These models include the ''Drift Degradation Analysis, Multiscale Thermohydrologic Model, Ventilation Model and Analysis Report, Igneous Intrusion Impacts on Waste Packages and Waste Forms, Drift-Scale Coupled Processes (DST and TH Seepage) Models'', and ''Drift Scale THM Model''. These models directly or indirectly provide input to the total system performance assessment (TSPA). The main distinguishing characteristic among the lithophysal and nonlithophysal units is the percentage of large-scale (centimeters-meters) voids within the rock. The Tptpul and Tptpll, as their names suggest, have a higher percentage of lithophysae than the Tptpmn and the Tptpln. Understanding the influence of the lithophysae is of great importance to understanding bulk thermal conductivity.

  1. Horizons of semiclassical black holes are cold

    NASA Astrophysics Data System (ADS)

    Brustein, Ram; Medved, A. J. M.

    2014-06-01

    We calculate, using our recently proposed semiclassical framework, the quantum state of the Hawking pairs that are produced during the evaporation of a black hole (BH). Our framework adheres to the standard rules of quantum mechanics and incorporates the quantum fluctuations of the collapsing shell spacetime in Hawking's original calculation, while accounting for back-reaction effects. We argue that the negative-energy Hawking modes need to be regularly integrated out; and so these are effectively subsumed by the BH and, as a result, the number of coherent negative-energy modes N coh at any given time is parametrically smaller than the total number of the Hawking particles N total emitted during the lifetime of the BH. We find that N coh is determined by the width of the BH wavefunction and scales as the square root of the BH entropy. We also find that the coherent negative-energy modes are strongly entangled with their positive-energy partners. Previously, we have found that N coh is also the number of coherent outgoing particles and that information can be continually transferred to the outgoing radiation at a rate set by N coh . Our current results show that, while the BH is semiclassical, information can be released without jeopardizing the nearly maximal inside-out entanglement and imply that the state of matter near the horizon is approximately the vacuum. The BH firewall proposal, on the other hand, is that the state of matter near the horizon deviates substantially from the vacuum, starting at the Page time. We find that, under the usual assumptions for justifying the formation of a firewall, one does indeed form at the Page time. However, the possible loophole lies in the implicit assumption that the number of strongly entangled pairs can be of the same order of N total .

  2. Observations of the Geometry of Horizon-Based Optical Navigation

    NASA Technical Reports Server (NTRS)

    Christian, John; Robinson, Shane

    2016-01-01

    NASA's Orion Project has sparked a renewed interest in horizon-based optical navigation(OPNAV) techniques for spacecraft in the Earth-Moon system. Some approaches have begun to explore the geometry of horizon-based OPNAV and exploit the fact that it is a conic section problem. Therefore, the present paper focuses more deeply on understanding and leveraging the various geometric interpretations of horizon-based OPNAV. These results provide valuable insight into the fundamental workings of OPNAV solution methods, their convergence properties, and associated estimate covariance. Most importantly, the geometry and transformations uncovered in this paper lead to a simple and non-iterative solution to the generic horizon-based OPNAV problem. This represents a significant theoretical advancement over existing methods. Thus, we find that a clear understanding of geometric relationships is central to the prudent design, use, and operation of horizon-based OPNAV techniques.

  3. Clinical practice on the horizon: personalized medicine.

    PubMed

    Chadwell, Katherine

    2013-01-01

    With the advent of the human genome project, we have never known so much about the uniqueness of individuals. Personalized medicine is poised to use this genetic and genomic information along with the impact of environment and clinical presentation to provide healthcare from an individual perspective. This offers the opportunity to improve our ability to diagnose and predict disease, provide earlier intervention, identify new treatment regimens, and address the safety and efficacy of drug use. The impact of personalized medicine to our current model of healthcare delivery is tremendous, and although strides have been made, there are still challenges and barriers to overcome before personalized medicine can be fully implemented. Advanced practice nurses may not be fully aware of the personalized medicine initiative or may not be well versed on genetic and genomic content, which is a key concept of personalized medicine. The role of advanced practice nurses is an integral part of the healthcare system, and as such, they are poised to be key providers and contributors to personalized medicine. The personalized medicine initiative is discussed along with examples of genetic and genomic information that lend to our understanding, diagnosis, and treatment of disease, as well as the role and responsibilities of advanced practice nurses. Resources for personalized medicine and genetic and genomic content are provided.

  4. 76 FR 55427 - Horizon Technology Finance Corporation, et al.; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... COMMISSION Horizon Technology Finance Corporation, et al.; Notice of Application August 31, 2011. AGENCY...(a) of the Act. Applicants: Horizon Technology Finance Corporation (the ``Company''), Horizon Technology Finance Management LLC (the ``Investment Adviser''), Longview SBIC GP LLC (the ``General...

  5. Asymmetric Michael addition of ketones to alkylidene malonates and allylidene malonates via enamine-metal Lewis acid bifunctional catalysis.

    PubMed

    Liu, Lu; Sarkisian, Ryan; Xu, Zhenghu; Wang, Hong

    2012-09-07

    Novel enamine-metal Lewis acid bifunctional catalysts were successfully applied to the asymmetric Michael addition of ketones to alkylidene malonates, offering excellent stereoselectivity (up to >99% ee and >99:1 dr). The asymmetric Michael addition of ketones to allylidene malonates was also achieved.

  6. 78 FR 2393 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. California Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v...), CAlifornians for Renewable Energy, Inc.; Michael E. Boyd; and Robert M. Sarvey filed a petition requesting...

  7. 78 FR 2390 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. Pacific Gas and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey... Renewable Energy, Inc.; Michael E. Boyd; and Robert M. Sarvey (Complainants) filed a complaint...

  8. Direct Catalytic Asymmetric Doubly Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactams to Dienones.

    PubMed

    Gu, Xiaodong; Guo, Tingting; Dai, Yuanyuan; Franchino, Allegra; Fei, Jie; Zou, Chuncheng; Dixon, Darren J; Ye, Jinxing

    2015-08-24

    An asymmetric doubly vinylogous Michael addition (DVMA) of α,β-unsaturated γ-butyrolactams to sterically congested β-substituted cyclic dienones with high site-, diastereo-, and enantioselectivity has been achieved. An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords chiral fused tricyclic γ-lactams with four newly formed stereocenters.

  9. Decarboxylative 1,4-Addition of α-Oxocarboxylic Acids with Michael Acceptors Enabled by Photoredox Catalysis.

    PubMed

    Wang, Guang-Zu; Shang, Rui; Cheng, Wan-Min; Fu, Yao

    2015-10-02

    Enabled by iridium photoredox catalysis, 2-oxo-2-(hetero)arylacetic acids were decarboxylatively added to various Michael acceptors including α,β-unsaturated ester, ketone, amide, aldehyde, nitrile, and sulfone at room temperature. The reaction presents a new type of acyl Michael addition using stable and easily accessible carboxylic acid to formally generate acyl anion through photoredox-catalyzed radical decarboxylation.

  10. 78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program....'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10.... Abstract: VA Form 10-0476 will be used to gather feedback from patients regarding their satisfaction...

  11. 76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... AFFAIRS Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program.... 2900-New (VA Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E... their satisfaction with the quality of services/care provided by home care program staff. An agency...

  12. 77 FR 40878 - Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey, v. California Public...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Californians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey... Utility Regulatory Policies Act of 1978 (PURPA), Californians for Renewable Energy, Inc., Michael E....

  13. Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes.

    PubMed

    Chen, Jia-Rong; Fu, Liang; Zou, You-Quan; Chang, Ning-Jie; Rong, Jian; Xiao, Wen-Jing

    2011-07-21

    A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).

  14. Direct Catalytic Asymmetric Doubly Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactams to Dienones**

    PubMed Central

    Gu, Xiaodong; Guo, Tingting; Dai, Yuanyuan; Franchino, Allegra; Fei, Jie; Zou, Chuncheng; Dixon, Darren J; Ye, Jinxing

    2015-01-01

    An asymmetric doubly vinylogous Michael addition (DVMA) of α,β-unsaturated γ-butyrolactams to sterically congested β-substituted cyclic dienones with high site-, diastereo-, and enantioselectivity has been achieved. An unprecedented DVMA/vinylogous Michael addition/isomerization cascade reaction affords chiral fused tricyclic γ-lactams with four newly formed stereocenters. PMID:26184079

  15. From Gouldner to Gramsci: The Making of Michael Apple's "Ideology and Curriculum"

    ERIC Educational Resources Information Center

    Gottesman, Isaac

    2012-01-01

    Michael Apple's "Ideology and Curriculum", published in 1979, helped initiate a broad turn in the field of education in the United States to Marxist thought as a lens through which to analyze the relationship between school and society. This classic text continues to inform scholarship in the field. While "Ideology" has…

  16. Enantioselective synthesis of coumarin derivatives by PYBOX-DIPH-Zn(II) complex catalyzed Michael reaction.

    PubMed

    Ray, Sumit K; Singh, Pradeep K; Molleti, Nagaraju; Singh, Vinod K

    2012-10-05

    A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn(OTf)(2) complex. The methodology has successfully been employed in the synthesis of (R)-Warfarin and another related compounds.

  17. Synthesis of Bicyclic Guanidines via Cascade Hydroamination/Michael Additions of Mono-N-acryloylpropargylguanidines

    PubMed Central

    2015-01-01

    A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene–guanidines and generates a remote stereocenter with moderate to high diastereoselectivity. PMID:25393831

  18. Chiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes.

    PubMed

    Yang, Wen; Du, Da-Ming

    2011-12-21

    An efficient highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes catalyzed by chiral squaramide catalyst has been developed. This organocatalytic reaction with a low catalyst loading (2 mol%) proceeded well to afford synthetically useful 1,3-dinitro compounds in high yields with high diastereoselectivities (up to 95 : 5 dr) and excellent enantioselectivities (up to 97% ee).

  19. Organocatalytic asymmetric assembly reactions for the syntheses of carbohydrate derivatives by intermolecular Michael-Henry reactions

    PubMed Central

    Uehara, Hisatoshi; Imashiro, Ritsuo; Hernández-Torres, Gloria; Barbas, Carlos F.

    2010-01-01

    Given the significance of carbohydrates in life, medicine, and industry, the development of simple and efficient de novo methods to synthesize carbohydrates are highly desirable. Organocatalytic asymmetric assembly reactions are powerful tools to rapidly construct molecules with stereochemical complexity from simple precursors. Here, we present a simple and robust methodology for the asymmetric synthesis of pyranose derivatives with talo- and manno- configurations from simple achiral precursors through organocatalytic asymmetric intermolecular Michael–Henry reaction sequences. In this process, (tert-butyldimethylsilyloxy)acetaldehyde 1 was successfully utilized in two ways: as a donor in a highly selective anti-Michael reaction and as an acceptor in a consecutive Henry reaction. Varied nitroolefins served as Michael acceptors and varied aldehydes substituted for 1 as Henry acceptors providing for the construction of a wide range of carbohydrates with up to 5 stereocenters. In these reactions, a catalyst-controlled Michael reaction followed by a substrate-controlled Henry reaction provided 3,4-dideoxytalose derivatives 6 in a highly stereoselective manner. The Henry reaction was affected by addition of a simple base such as triethylamine: A complex chiral base was not necessary. 3,4-Dideoxymannose derivatives 7 were produced by simply changing the base from triethylamine to 1,8-diazabicyclo[5.4.0]undec-7-ene. Extension of this methodology to a syn-Michael initiated sequence was also successful. A mechanistic discussion is provided to explain the unusual substrate-induced stereoselectivity of the Henry reaction. PMID:20639468

  20. Enantioselective Aza Michael-Type Addition to Alkenyl Benzimidazoles Catalyzed by a Chiral Phosphoric Acid.

    PubMed

    Wang, Ya-Yi; Kanomata, Kyohei; Korenaga, Toshinobu; Terada, Masahiro

    2016-01-18

    Highly enantioselective Michael-type addition (MTA) reactions between N-protected alkenyl benzimidazoles and either pyrazoles or indazoles as nitrogen nucleophiles are accomplished for the first time using chiral phosphoric acid catalyst. Theoretical studies elucidated the reaction pathway and the origin of the stereochemical outcomes, where the catalyst substituent and the N-protecting group of benzimidazole contributed to the resulting high enantioselectivity.

  1. A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones.

    PubMed

    Ban, Shu-Rong; Zhu, Xi-Xia; Zhang, Zhi-Ping; Li, Qing-Shan

    2014-06-01

    A benzoylthiourea-pyrrolidine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding products were obtained in high yields with high level of diastereoselectivities (up to 99:1 dr) and high level of enantioselectivities (up to 94% ee) under mild conditions.

  2. Irish Education for the 21st Century. Michael Enright Commemorative Project.

    ERIC Educational Resources Information Center

    Ward, Noel, Ed.; Dooney, Triona, Ed.

    The essays in this collection contribute to the ongoing discussion about the state of Irish education on the threshold of a new century. The various contributors examine issues that will be priorities for education planners in Ireland. These essays have been collected as a tribute to Irish educator and politician Michael Enright. The essays are:…

  3. An Asymmetric Vinylogous Michael Cascade of Silyl Glyoximide, Vinyl Grignard, and Nitroalkenes via Long Range Stereoinduction

    PubMed Central

    Boyce, Gregory R.; Johnson, Jeffrey S.

    2016-01-01

    A diastereoselective auxiliary-mediated vinylation/[1,2]-Brook rearrangement/vinylogous Michael cascade of silyl glyoximide, vinylmagnesium bromide, and nitroalkenes is described. The reaction occurs with complete regio- and diastereocontrol in good yield. The diastereoselectivity is induced by a rare instance of 1,7-chirality transfer that is hypothesized to arise from a trans-multihetero-decalin transition state. PMID:26833255

  4. Michael Peters' Lyotardian Account of Postmodernism and Education: Some Epistemic Problems and Naturalistic Solutions

    ERIC Educational Resources Information Center

    Clark, John A.

    2006-01-01

    Postmodernism has established a significant hold in educational thought and some of the most important ideas are to be found in the writings of Michael Peters. This paper examines his postmodern stance and use of Lyotard's account of knowledge, and from a naturalist point of view raises a number of objections centred on science as a metanarrative,…

  5. C. P. Snow's "The Two Cultures": Michael Polanyi's Response and Context

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2011-01-01

    C. P. Snow's "The Two Cultures" controversially contrasted science and literature, suggesting that neither scientists nor literary intellectuals have much in common with, and seldom bother speaking to, the other. Responding to Snow, Michael Polanyi argued that specialization has made modern culture, not twofold but manifold. In his major work,…

  6. Michael Faraday on the Learning of Science and Attitudes of Mind.

    ERIC Educational Resources Information Center

    Crawford, Elspeth

    1998-01-01

    Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

  7. Michael Eric Dyson: A Scholar and a Hip-Hop Preacher.

    ERIC Educational Resources Information Center

    Fletcher, Michael A.

    2000-01-01

    Introduces Michael Eric Dyson, an African American man who grew up in the ghetto and eventually received a PhD from Princeton University. Today, he is a professor at DePaul University, the author of a radically revisionist new biography of Martin Luther King, Jr., a lecturer and talk show guest, a Baptist preacher, and a self-styled hip-hop…

  8. A Response to Michael W. Apple's "Theory, Research, and the Critical Scholar/Activist"

    ERIC Educational Resources Information Center

    Leonardo, Zeus

    2010-01-01

    Michael Apple's prescient review of Anyon et al.'s "Theory and Educational Research" reminds the educational community of the importance of purpose. In his own work, he has been consistent in--actually, insistent on--emphasizing the struggle over political projects. This is not an issue concerning only the Left as the scapegoat for the disparaging…

  9. Synthesis of bicyclic guanidines via cascade hydroamination/Michael additions of mono-N-acryloylpropargylguanidines.

    PubMed

    Kwon, Ki-Hyeok; Serrano, Catherine M; Koch, Michael; Barrows, Louis R; Looper, Ryan E

    2014-12-05

    A cascade silver(I)-catalyzed hydroamination/Michael addition sequence has been developed to deliver highly substituted bicyclic guanidines. This transformation gives rise to geometrically and constitutionally stable ene-guanidines and generates a remote stereocenter with moderate to high diastereoselectivity.

  10. Learning to Lose: Rurality, Transience, and Belonging (A Companion to Michael Corbett)

    ERIC Educational Resources Information Center

    Kelly, Ursula A.

    2009-01-01

    In this commentary, the author focuses on the central point of Michael Corbett's book "Learning to Leave". Education, and in particular what is called "rural" education, is premised on loss. This loss is often not fully articulated, but it is deep and abiding. It is registered in efforts to stop the flow of people and…

  11. Neuroscientific Investigator of High Mathematical Ability: An Interview with Michael W. O'Boyle

    ERIC Educational Resources Information Center

    Kalbfleisch, M. Layne

    2008-01-01

    This article presents an interview with Michael W. O'Boyle, a neuroscientific investigator of high mathematical ability. O'Boyle is a professor in the Department of Human Development and Family Studies, Texas Tech University, and Adjunct Professor of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center.…

  12. Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

    NASA Astrophysics Data System (ADS)

    Brendel, Michelle

    2014-12-01

    Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

  13. Schools as "Poetry-Friendly Places": Michael Rosen on Poetry in the Curriculum

    ERIC Educational Resources Information Center

    Xerri, Daniel

    2014-01-01

    This article explores the views of children's poet Michael Rosen in relation to poetry in education. It is based on an interview in which Rosen not only discusses the significance of encouraging young people to engage with poetry at school but also analyzes a number of threats to poetry's place in the English curriculum. This article identifies…

  14. Why Do We Need a Philosophy of Education? The Forgotten Insights of Michael John Demiashkevich

    ERIC Educational Resources Information Center

    Senechal, Diana

    2010-01-01

    For many decades, American schools have been mired in jargon and confused values. A few exceptional books have shown the way through the thicket of educational ideas, policies, and practices. The work of Michael John Demiashkevich belongs to this set and offers a special philosophical perspective. In "An Introduction to the Philosophy of…

  15. A tribute to Michael R. Raupach for contributions to aeolian fluid dynamics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Since the early work of Bagnold in the 1940s, aeolian research has grown to become a major integral part of earth-system studies. Many individuals have contributed to this development, and Dr. Michael R. Raupach (MR2, 1950 – 2015) was one of the most outstanding. MR2 worked for about a decade (1985 ...

  16. Asymmetric Michael addition reactions of nitroalkanes to 2-furanones catalyzed by bifunctional thiourea catalysts.

    PubMed

    Bai, Zhushuang; Ji, Ling; Ge, Zemei; Wang, Xin; Li, Runtao

    2015-05-21

    The first bifunctional thiourea catalyzed asymmetric Michael addition reactions of nitroalkanes to 2-furanones are described. The highly functionalized γ-lactones with two or three consecutive stereogenic carbons were obtained in high yields (up to 99%), high diastereoselectivities (up to >20 : 1 dr) and enantioselectivities (up to >99% ee).

  17. Michael E. Barnes: Award for Distinguished Professional Contributions to Institutional Practice

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents a short biography on the winner of the American Psychological Association's Award for Distinguished Professional Contributions to Institutional Practice. The 2012 winner is Michael E. Barnes for his pioneering leadership, dedication, and distinguished contributions to juvenile justice. As chief psychologist of the Superior Court of the…

  18. A Tandem Michael-Aldol Reaction Sequence: An Undergraduate Research Organic Experiment.

    ERIC Educational Resources Information Center

    Coutlangus, Marilyn L.; And Others

    1989-01-01

    Presents a short reaction sequence that allows the student to determine by spectroscopic methods the constitution and stereochemistry of the reaction products. Reports the interpretations needed to illustrate the usefulness of the spectroscopic method. Notes the products of the Michael-Aldol reaction have not been reported in the literature. (MVL)

  19. Astronaut C. Michael Foale is briefed on use of Sky Genie

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Astronaut C. Michael Foale, STS-63 mission specialist, is briefed on the use of Sky Genie device by Karin L. Porter. The device would aid in emergency egress operations aboard a troubled Space Shuttle. Porter, an employee of Rockwell International, helps train astronauts in egress procedures at JSC's Shuttle mockup and integration laboratory.

  20. Enantioselective Michael addition/iminium ion cyclization cascades of tryptamine-derived ureas.

    PubMed

    Aillaud, Isabelle; Barber, David M; Thompson, Amber L; Dixon, Darren J

    2013-06-21

    A Michael addition/iminium ion cyclization cascade of enones with tryptamine-derived ureas under BINOL phosphoric acid (BPA) catalysis is reported. The cascade reaction tolerates a wide variety of easily synthesized tryptamine-derived ureas, including those bearing substituents on the distal nitrogen atom of the urea moiety, affording polyheterocyclic products in good yields and good to excellent enantioselectivities.

  1. A macrocyclic approach to tetracycline natural products. Investigation of transannular alkylations and Michael additions.

    PubMed

    Wzorek, Joseph S; Knöpfel, Thomas F; Sapountzis, Ioannis; Evans, David A

    2012-12-07

    A new approach to the tetracycline core structure is presented. The pivotal intermediate is identified as macrocycle III. The two interior bonds (C4a-C12a and C5a-C11a) are to be constructed through sequential transannular Michael additions (III-II) and compression-promoted transannular isoxazole alkylations from intermediate II.

  2. Q & A with Ed Tech Leaders: Interview with J. Michael Spector

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2015-01-01

    J. Michael Spector's academic preparation was in philosophy--epistemology and logic, primarily. His dissertation was on skepticism in modern philosophy, and that led him to a deep-seated appreciation for classical skepticism. The word "skeptic" is derived from the Greek word "skepsis," which means investigation. While the…

  3. Michael Duane after Risinghill: Rise and Fall of an Educational Celebrity

    ERIC Educational Resources Information Center

    Limond, David

    2005-01-01

    In this article an attempt is made to examine the continuing implications of the operation and closure of London's Risinghill school, a co-educational comprehensive extant from 1960 to 1965. It is suggested that Risinghill's controversial headteacher, Michael Duane (1915-1997), was an educational celebrity and folk hero amongst teachers and in…

  4. Q & A with Ed Tech Leaders: Interview with Michael W. Allen

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.

    2014-01-01

    Michael W. Allen, the Chairman and CEO of Allen Interactions, is an architect of interactive multimedia learning and is recognized for his many insights, inventions, and presentations. With over 50 years of experience in e-learning, both in academic and corporate settings, he is known for his role in creating Authorware and overseeing the work of…

  5. Broadening the Debate: Comments on Michael J. Feuer's "Moderating the Debate"

    ERIC Educational Resources Information Center

    Robertson, Emily

    2009-01-01

    In "Moderating the Debate: Rationality and the Promise of American Education", Michael Feuer argues that insights from cognitive science and the theory of bounded rationality can help us understand why educational policy makers overreach in seeking optimal solutions to educational problems. In this essay, Emily Robertson argues that cognitive…

  6. Little Mosie from the Margaree: A Biography of Moses Michael Coady.

    ERIC Educational Resources Information Center

    Welton, Michael R.

    This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

  7. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    PubMed

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age.

  8. What Work Do the Concepts of "Language" and "Literature" Do for Michael Rosenak?

    ERIC Educational Resources Information Center

    Levisohn, Jon A.

    2014-01-01

    Michael Rosenak uses the twin metaphors of "language" and "literature," borrowed from Oakeshott and Peters, to argue that the goal of education is initiation into a language. This goal transcends the study of literature in that language. It includes, as well, the development of the capacity both to critique literature and to…

  9. The Oral History of Evaluation, Part 5: An Interview with Michael Quinn Patton

    ERIC Educational Resources Information Center

    King, Jean; Greenseid, Lija

    2007-01-01

    This article presents an interview with Michael Patton whose professional evolution has contributed to the way evaluation in the United States is understood and practiced today. Patton is an evaluation and organizational development consultant who spent 18 years at the University of Minnesota (1973-1991), including 5 years as the director of the…

  10. Education, Philosophy and Politics: The Selected Works of Michael A. Peters. World Library of Educationalists

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2012-01-01

    In the World Library of Educationalists series, international experts themselves compile career-long collections of what they judge to be their finest pieces--extracts from books, key articles, salient research findings, major theoretical and/practical contributions--so the world can read them in a single manageable volume. Michael A. Peters has…

  11. The Benevolent Technocrat: Michael Dukakis' Strategy in the 1988 Presidential Debates.

    ERIC Educational Resources Information Center

    Herbeck, Dale A.

    Michael Dukakis lost the presidential campaign debates of 1988 (or at least failed to capitalize as much as he might have) because he understood the debates to be genuine debates. Consequently, Dukakis acted as a debater generating an image of himself as a "benevolent technocrat," which was an error. It must be pointed out that the…

  12. Moral Education and Education in Altruism: Two Replies to Michael Hand

    ERIC Educational Resources Information Center

    White, John

    2016-01-01

    This article is a critical discussion of two recent papers by Michael Hand on moral education. The first is his "Towards a Theory of Moral Education", published in the "Journal of Philosophy of Education" in 2014 (Volume 48, Issue 4). The second is a chapter called "Beyond Moral Education?" in an edited book of new…

  13. 76 FR 21406 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Michael J. Aruta, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration published the above-titled Decision and Order, as well as...

  14. Subjectivity and Cultural Adjustment in Mathematics Education: A Response to Wolff-Michael Roth

    ERIC Educational Resources Information Center

    Brown, Tony

    2012-01-01

    In this volume, Wolff-Michael Roth provides a critical but partial reading of Tony Brown's book "Mathematics Education and Subjectivity". The reading contrasts Brown's approach with Roth's own conception of subjectivity as derived from the work of Vygotsky, in which Roth aims to "reunite" psychology and sociology. Brown's book, however, focuses on…

  15. "Raising Standards" or Reducing Aspirations and Opportunities Still Further? Michael Gove and Examination Reforms

    ERIC Educational Resources Information Center

    Allen, Martin

    2013-01-01

    Well before the examinations grade crisis of 2012, Michael Gove had set out clear intentions for reforming public examinations. Though he claimed to be improving examinations and assessment by replicating practices that took place in high-performing countries and thus improving the ability of the UK economy to "compete", this…

  16. Training and Mastery of Techniques in Wittgenstein's Later Philosophy: A Response to Michael Luntley

    ERIC Educational Resources Information Center

    Stickney, Jeff

    2008-01-01

    Responding to Michael Luntley's article, "Learning, Empowerment and Judgement," the author shows he cannot successfully make the following three moves: (1) dissolve the analytic distinction between learning by training and learning by reasoning, while advocating the latter; (2) diminish the role of training in Wittgenstein's philosophy, nor…

  17. Spacetimes foliated by nonexpanding and Killing horizons: Higher dimension

    NASA Astrophysics Data System (ADS)

    Lewandowski, Jerzy; Szereszewski, Adam; Waluk, Piotr

    2016-09-01

    The theory of nonexpanding horizons (NEHs) geometry and the theory of near-horizon geometries (NHGs) are two mathematical relativity frameworks generalizing the black hole theory. From the point of view of the NEHs theory, a NHG is just a very special case of a spacetime containing a NEH of many extra symmetries. It can be obtained as the Horowitz limit of a neighborhood of an arbitrary extremal Killing horizon. An unexpected relation between the two of them was discovered in the study of spacetimes foliated by a family of NEHs. The class of four-dimensional NHG solutions (either vacuum or coupled to a Maxwell field) was found as a family of examples of spacetimes admitting a NEH foliation. In the current paper, we systematically investigate geometries of the NEHs foliating a spacetime for arbitrary matter content and in arbitrary spacetime dimensions. We find that each horizon belonging to the foliation satisfies a condition that may be interpreted as an invitation for a transversal NEH to exist and to admit the structure of an extremal isolated horizon. Assuming the existence of a transversal extremal isolated horizon, we derive all the spacetime metrics satisfying the vacuum Einstein's equations. In this case, the NEHs become bifurcated Killing horizons.

  18. Physical process first law for bifurcate Killing horizons

    SciTech Connect

    Amsel, Aaron J.; Marolf, Donald; Virmani, Amitabh

    2008-01-15

    The physical process version of the first law for black holes states that the passage of energy and angular momentum through the horizon results in a change in area ({kappa}/8{pi}){delta}A={delta}E-{omega}{delta}J, so long as this passage is quasistationary. A similar physical process first law can be derived for any bifurcate Killing horizon in any spacetime dimension d{>=}3 using much the same argument. However, to make this law nontrivial, one must show that sufficiently quasistationary processes do in fact occur. In particular, one must show that processes exist for which the shear and expansion remain small, and in which no new generators are added to the horizon. Thorne, MacDonald, and Price considered related issues when an object falls across a d=4 black hole horizon. By generalizing their argument to arbitrary d{>=}3 and to any bifurcate Killing horizon, we derive a condition under which these effects are controlled and the first law applies. In particular, by providing a nontrivial first law for Rindler horizons, our work completes the parallel between the mechanics of such horizons and those of black holes for d{>=}3. We also comment on the situation for d=2.

  19. A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES WITH GENOMIC, PROTEOMIC AND METABONOMIC COMPONENTS

    EPA Science Inventory

    A Database for Tracking Toxicogenomic Samples and Procedures with Genomic, Proteomic and Metabonomic Components
    Wenjun Bao1, Jennifer Fostel2, Michael D. Waters2, B. Alex Merrick2, Drew Ekman3, Mitchell Kostich4, Judith Schmid1, David Dix1
    Office of Research and Developmen...

  20. Quantum correlations through event horizons: Fermionic versus bosonic entanglement

    SciTech Connect

    Martin-Martinez, Eduardo; Leon, Juan

    2010-03-15

    We disclose the behavior of quantum and classical correlations among all the different spatial-temporal regions of a space-time with an event horizon, comparing fermionic with bosonic fields. We show the emergence of conservation laws for entanglement and classical correlations, pointing out the crucial role that statistics plays in the information exchange (and more specifically, the entanglement tradeoff) across horizons. The results obtained here could shed new light on the problem of information behavior in noninertial frames and in the presence of horizons, giving better insight into the black-hole information paradox.

  1. Horizon scan of global conservation issues for 2011.

    PubMed

    Sutherland, William J; Bardsley, Sarah; Bennun, Leon; Clout, Mick; Côté, Isabelle M; Depledge, Michael H; Dicks, Lynn V; Dobson, Andrew P; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Impey, Andrew J; Lawton, John H; Lickorish, Fiona; Lindenmayer, David B; Lovejoy, Thomas E; Nally, Ralph Mac; Madgwick, Jane; Peck, Lloyd S; Pretty, Jules; Prior, Stephanie V; Redford, Kent H; Scharlemann, Jörn P W; Spalding, Mark; Watkinson, Andrew R

    2011-01-01

    This review describes outcomes of a 2010 horizon-scanning exercise building upon the first exercise conducted in 2009. The aim of both horizon scans was to identify emerging issues that could have substantial impacts on the conservation of biological diversity, and to do so sufficiently early to encourage policy-relevant, practical research on those issues. Our group included professional horizon scanners and researchers affiliated with universities and non- and inter-governmental organizations, including specialists on topics such as invasive species, wildlife diseases and coral reefs. We identified 15 nascent issues, including new greenhouse gases, genetic techniques to eradicate mosquitoes, milk consumption in Asia and societal pessimism.

  2. LANDSAT-4 horizon scanner performance evaluation

    NASA Technical Reports Server (NTRS)

    Bilanow, S.; Chen, L. C.; Davis, W. M.; Stanley, J. P.

    1984-01-01

    Representative data spans covering a little more than a year since the LANDSAT-4 launch were analyzed to evaluate the flight performance of the satellite's horizon scanner. High frequency noise was filtered out by 128-point averaging. The effects of Earth oblateness and spacecraft altitude variations are modeled, and residual systematic errors are analyzed. A model for the predicted radiance effects is compared with the flight data and deficiencies in the radiance effects modeling are noted. Correction coefficients are provided for a finite Fourier series representation of the systematic errors in the data. Analysis of the seasonal dependence of the coefficients indicates the effects of some early mission problems with the reference attitudes which were computed by the onboard computer using star trackers and gyro data. The effects of sun and moon interference, unexplained anomalies in the data, and sensor noise characteristics and their power spectrum are described. The variability of full orbit data averages is shown. Plots of the sensor data for all the available data spans are included.

  3. New geometries for black hole horizons

    NASA Astrophysics Data System (ADS)

    Armas, Jay; Blau, Matthias

    2015-07-01

    We construct several classes of worldvolume effective actions for black holes by integrating out spatial sections of the worldvolume geometry of asymptotically flat black branes. This provides a generalisation of the blackfold approach for higher-dimensional black holes and yields a map between different effective theories, which we exploit by obtaining new hydrodynamic and elastic transport coefficients via simple integrations. Using Euclidean minimal surfaces in order to decouple the fluid dynamics on different sections of the worldvolume, we obtain local effective theories for ultraspinning Myers-Perry branes and helicoidal black branes, described in terms of a stress-energy tensor, particle currents and non-trivial boost vectors. We then study in detail and present novel compact and non-compact geometries for black hole horizons in higher-dimensional asymptotically flat space-time. These include doubly-spinning black rings, black helicoids and helicoidal p-branes as well as helicoidal black rings and helicoidal black tori in D ≥ 6.

  4. Polarimetric VLBI with the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Fish, Vincent L.; Doeleman, S.; Marrone, D. P.; Lu, R.; Wardle, J. F.; EHT Collaboration

    2013-01-01

    The Event Horizon Telescope is a collaboration to observe the innermost accretion and outflow regions around supermassive black holes with an array of millimeter-wavelength telescopes. EHT observations have detected emission on scales of tens of microarcseconds around the black holes in the center of the Milky Way and M87. Non-polarimetric measurements have successfully been used to identify and model the Schwarzschild-radius-scale emission around these sources as well as to identify previously unresolvable structures in more distant AGNs and blazars, but new polarimetric data can provide additional information on the magnetic field strength and geometry in the jet launch and collimation region. Recent full-polarization VLBI observations with the EHT have detected polarized 1.3 mm emission arising on extremely small angular scales in a variety of extragalactic sources. We report on the results of these detections and detail the prospects for precision polarimetry thanks to the substantial EHT sensitivity improvements that will be realized over the next few years.

  5. New Developments with the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Fish, Vincent L.; Doeleman, S.; Krichbaum, T.; Zensus, A.; Event Horizon Telescope Collaboration

    2014-01-01

    The Event Horizon Telescope is an international collaboration to observe nearby supermassive black holes with millimeter-wavelength very long baseline interferometry in order to probe the region of the black hole shadow. Previous observations have placed strong constraints on the morphology of the emitting region around Sagittarius A* and the supermassive black hole in the center of M87, resulting in greater insight into the processes of accretion and outflow around black holes. Substantial advances in data quality have been made in the most recent March 2013 observations. Linear polarization has been clearly detected toward a variety of sources on angular scales of tens to hundreds of microarcseconds. Interhemispheric fringes, both North-South and East-West, were obtained, providing the best EHT baseline coverage to date. Technical progress on other stations that may participate in the 1.3 mm VLBI array, including a successful 3 mm VLBI experiment with the Large Millimeter Telescope and continued development of the ALMA beamformer, will soon increase the array sensitivity and baseline coverage, permitting imaging of black holes for the first time.

  6. Possible New Horizons Fundamental Contribution to Cosmology

    NASA Astrophysics Data System (ADS)

    Conn Henry, Richard; Murthy, Jayant

    2016-01-01

    The New Horizons (NH) spacecraft (S. Alan Stern, PI) is now past Pluto, and in our poster we explore the possibility of making observations, using the NH P-Alice ultraviolet spectrometer, of the cosmic diffuse ultraviolet background radiation, particularily at high northern and southern Galactic latitudes. In the paper, "The Mystery of the Cosmic Diffuse Ultraviolet Background Radiation," by Richard Conn Henry, Jayant Murthy, James Overduin, Joshua Tyler, ApJ, 798:14 (25pp), 2015 January 1, we demonstrated the existence of a second component of the diffuse far ultraviolet background radiation beyond that provided by dust-scattered starlight. The critical question is, does that second component (of unknown origin) extend shortward of the Lyman limit of 912 Å? If it does, then it seems likely that we have discovered the source of the reionization of the Universe that occurred some time after recombination. As things stand at the moment, there is no known source that has been demonstrated to be capable of performing the reionization: reionization that clearly did occur. Our current understanding of P-Alice suggests that it may well be capable of demonstrating the presence (or absence) of such ionizing cosmic diffuse radiation. At low Galactic latitudes, all such radiation would be totally erased by the presence, in large quantities, of interstellar neutral hydrogen; this will allow us to test the reality of any such flux that we may discover at higher Galactic latitudes.

  7. Beyond the event horizon or altogether without it?

    NASA Astrophysics Data System (ADS)

    Lobanov, Andrei

    2017-03-01

    Millimetre-wavelength interferometry and gravitational-wave detectors currently provide the most stringent tests for the existence of cosmic black holes. Complementary measurements of magnetic fields near their event horizon would be decisive.

  8. The absence of horizon in black-hole formation

    NASA Astrophysics Data System (ADS)

    Ho, Pei-Ming

    2016-08-01

    With the back-reaction of Hawking radiation taken into consideration, the work of Kawai, Matsuo and Yokokura [1] has shown that, under a few assumptions, the collapse of matter does not lead to event horizon nor apparent horizon. In this paper, we relax their assumptions and elaborate on the space-time geometry of a generic collapsing body with spherical symmetry. The geometry outside the collapsing sphere is found to be approximated by the geometry outside the white-hole horizon, hence the collapsing matter remains outside the Schwarzschild radius. As particles in Hawking radiation are created in the vicinity of the collapsing matter, the information loss paradox is alleviated. Assuming that the collapsing body evaporates within finite time, there is no event horizon.

  9. Complementary and Alternative Medicine (CAM): Expanding Horizons of Health Care

    MedlinePlus

    ... Past Issues Special Section CAM Expanding Horizons of Health Care Past Issues / Winter 2009 Table of Contents For ... and why it is important to tell your health care providers about your use of CAM. We hope ...

  10. Hints of quantum gravity from the horizon fluid

    NASA Astrophysics Data System (ADS)

    Cropp, Bethan; Bhattacharya, Swastik; Shankaranarayanan, S.

    2017-01-01

    For many years, researchers have tried to glean hints about quantum gravity from black hole thermodynamics. However, black hole thermodynamics suffers from the problem of universality—at leading order, several approaches with different microscopic degrees of freedom lead to Bekenstein-Hawking entropy. We attempt to bypass this issue by using a minimal statistical mechanical model for the horizon fluid based on the Damour-Navier-Stokes (DNS) equation. For stationary asymptotically flat black hole spacetimes in general relativity, we show explicitly that, at equilibrium, the entropy of the horizon fluid is the Bekenstein-Hawking entropy. Further, we show that, for the bulk viscosity of the fluctuations of the horizon fluid to be identical to Damour, a confinement scale exists for these fluctuations, implying quantization of the horizon area. The implications and possible mechanisms from the fluid point of view are discussed.

  11. Deepwater Horizon – BP Gulf of Mexico Oil Spill

    EPA Pesticide Factsheets

    This webpage provides information and materials on EPA’s enforcement response to the Deepwater Horizon Oil Spill, including settlements with some of the defendants, as well as links to other related websites for additional information.

  12. Einstein–Weyl spaces and near-horizon geometry

    NASA Astrophysics Data System (ADS)

    Dunajski, Maciej; Gutowski, Jan; Sabra, Wafic

    2017-02-01

    We show that a class of solutions of minimal supergravity in five dimensions is given by lifts of three-dimensional Einstein–Weyl structures of hyper-CR type. We characterise this class as most general near-horizon limits of supersymmetric solutions to the five-dimensional theory. In particular we deduce that a compact spatial section of a horizon can only be a Berger sphere, a product metric on {{S}1}× {{S}2} or a flat three-torus. We then consider the problem of reconstructing all supersymmetric solutions from a given near-horizon geometry. By exploiting the ellipticity of the linearised field equations we demonstrate that the moduli space of transverse infinitesimal deformations of a near-horizon geometry is finite-dimensional.

  13. Horizon Based Orientation Estimation for Planetary Surface Navigation

    NASA Technical Reports Server (NTRS)

    Bouyssounouse, X.; Nefian, A. V.; Deans, M.; Thomas, A.; Edwards, L.; Fong, T.

    2016-01-01

    Planetary rovers navigate in extreme environments for which a Global Positioning System (GPS) is unavailable, maps are restricted to relatively low resolution provided by orbital imagery, and compass information is often lacking due to weak or not existent magnetic fields. However, an accurate rover localization is particularly important to achieve the mission success by reaching the science targets, avoiding negative obstacles visible only in orbital maps, and maintaining good communication connections with ground. This paper describes a horizon solution for precise rover orientation estimation. The detected horizon in imagery provided by the on board navigation cameras is matched with the horizon rendered over the existing terrain model. The set of rotation parameters (roll, pitch yaw) that minimize the cost function between the two horizon curves corresponds to the rover estimated pose.

  14. Universal properties of the near-horizon optical geometry

    SciTech Connect

    Gibbons, G. W.; Warnick, C. M.

    2009-03-15

    Making use of the fact that the optical geometry near a static nondegenerate Killing horizon is asymptotically hyperbolic, we investigate some universal features of black-hole horizons. Applying the Gauss-Bonnet theorem allows us to establish some general properties of gravitational lensing, valid for all black holes. Hyperbolic geometry allows us to find rates for the loss of scalar, vector, and fermionic ''hair'' as objects fall quasistatically towards the horizon, extending previous results for Schwarzschild to all static Killing horizons. In the process we find the Lienard-Wiechert potential for hyperbolic space and calculate the force between electrons mediated by neutrinos, extending the flat space result of Feinberg and Sucher. We further demonstrate how these techniques allow us to derive the exact Copson-Linet potential due to a point charge in a Schwarzschild background in a simple fashion.

  15. Note on electrical and thermodynamic properties of isolated horizons

    NASA Astrophysics Data System (ADS)

    Chen, Gerui; Wu, Xiaoning; Gao, Sijie

    2015-03-01

    The electrical laws and Carnot cycle of isolated horizons (IH) are investigated in this paper. We establish Ohm's law and Joule's law of isolated horizons and find that the conceptual picture of black holes (membrane paradigm) can also apply to this kind of quasilocal black holes. We also investigate the geometrical properties near nonrotating IHs and find that under the first-order approximation of r , there exist a Killing vector ∂∂u/ and a Hamiltonian conjugate to it, so this vector can be thought to be a physical observer. We calculate the energy as measured at infinity of a particle at rest outside a nonrotating IH, and we use this result to construct a reversible Carnot cycle with the isolated horizon as a cold reservoir, which confirms the thermodynamic nature of isolated horizons.

  16. Supertranslations and Superrotations at the Black Hole Horizon.

    PubMed

    Donnay, Laura; Giribet, Gaston; González, Hernán A; Pino, Miguel

    2016-03-04

    We show that the asymptotic symmetries close to nonextremal black hole horizons are generated by an extension of supertranslations. This group is generated by a semidirect sum of Virasoro and Abelian currents. The charges associated with the asymptotic Killing symmetries satisfy the same algebra. When considering the special case of a stationary black hole, the zero mode charges correspond to the angular momentum and the entropy at the horizon.

  17. Evaporating dynamical horizon with the Hawking effect in Vaidya spacetime

    SciTech Connect

    Sawayama, Shintaro

    2006-03-15

    We consider how the mass of the black hole decreases due to the Hawking radiation in the Vaidya spacetime, using the concept of the dynamical horizon equation, proposed by Ashtekar and Krishnan. Using the formula for the change of the dynamical horizon, we derive an equation for the mass incorporating the Hawking radiation. It is shown that the final state is the Minkowski spacetime in our particular model.

  18. Waste Sampling Data for BP Spill/Deepwater Horizon

    EPA Pesticide Factsheets

    The Deepwater Horizon oil spill (also referred to as the BP oil spill) began on 20 April 2010 in the Gulf of Mexico on the BP-operated Macondo Prospect. Following the explosion and sinking of the Deepwater Horizon oil rig, a sea-floor oil gusher flowed for 87 days, until it was capped on 15 July 2010.In response to the BP oil spill, EPA sampled air, water, sediment, and waste generated by the cleanup operations.

  19. Air Sampling Data for BP Spill/Deepwater Horizon

    EPA Pesticide Factsheets

    The Deepwater Horizon oil spill (also referred to as the BP oil spill) began on 20 April 2010 in the Gulf of Mexico on the BP-operated Macondo Prospect. Following the explosion and sinking of the Deepwater Horizon oil rig, a sea-floor oil gusher flowed for 87 days, until it was capped on 15 July 2010.In response to the BP oil spill, EPA sampled air, water, sediment, and waste generated by the cleanup operations.

  20. Air Monitoring Data for BP Spill/Deepwater Horizon

    EPA Pesticide Factsheets

    The Deepwater Horizon oil spill (also referred to as the BP oil spill) began on 20 April 2010 in the Gulf of Mexico on the BP-operated Macondo Prospect. Following the explosion and sinking of the Deepwater Horizon oil rig, a sea-floor oil gusher flowed for 87 days, until it was capped on 15 July 2010.In response to the BP oil spill, EPA sampled air, water, sediment, and waste generated by the cleanup operations.

  1. Surface Water Sampling Data for BP Spill/Deepwater Horizon

    EPA Pesticide Factsheets

    The Deepwater Horizon oil spill (also referred to as the BP oil spill) began on 20 April 2010 in the Gulf of Mexico on the BP-operated Macondo Prospect. Following the explosion and sinking of the Deepwater Horizon oil rig, a sea-floor oil gusher flowed for 87 days, until it was capped on 15 July 2010.In response to the BP oil spill, EPA sampled air, water, sediment, and waste generated by the cleanup operations.

  2. Sediment Sampling Data for BP Spill/Deepwater Horizon

    EPA Pesticide Factsheets

    The Deepwater Horizon oil spill (also referred to as the BP oil spill) began on 20 April 2010 in the Gulf of Mexico on the BP-operated Macondo Prospect. Following the explosion and sinking of the Deepwater Horizon oil rig, a sea-floor oil gusher flowed for 87 days, until it was capped on 15 July 2010.In response to the BP oil spill, EPA sampled air, water, sediment, and waste generated by the cleanup operations.

  3. Water Sampling Data for BP Spill/Deepwater Horizon

    EPA Pesticide Factsheets

    The Deepwater Horizon oil spill (also referred to as the BP oil spill) began on 20 April 2010 in the Gulf of Mexico on the BP-operated Macondo Prospect. Following the explosion and sinking of the Deepwater Horizon oil rig, a sea-floor oil gusher flowed for 87 days, until it was capped on 15 July 2010.In response to the BP oil spill, EPA sampled air, water, sediment, and waste generated by the cleanup operations.

  4. A horizon scan of global conservation issues for 2010.

    PubMed

    Sutherland, William J; Clout, Mick; Côté, Isabelle M; Daszak, Peter; Depledge, Michael H; Fellman, Liz; Fleishman, Erica; Garthwaite, Rachel; Gibbons, David W; De Lurio, Jennifer; Impey, Andrew J; Lickorish, Fiona; Lindenmayer, David; Madgwick, Jane; Margerison, Ceri; Maynard, Trevor; Peck, Lloyd S; Pretty, Jules; Prior, Stephanie; Redford, Kent H; Scharlemann, Jörn P W; Spalding, Mark; Watkinson, Andrew R

    2010-01-01

    Horizon scanning identifies emerging issues in a given field sufficiently early to conduct research to inform policy and practice. Our group of horizon scanners, including academics and researchers, convened to identify fifteen nascent issues that could affect the conservation of biological diversity. These include the impacts of and potential human responses to climate change, novel biological and digital technologies, novel pollutants and invasive species. We expect to repeat this process and collation annually.

  5. A horizon scan of global conservation issues for 2015.

    PubMed

    Sutherland, William J; Clout, Mick; Depledge, Michael; Dicks, Lynn V; Dinsdale, Jason; Entwistle, Abigail C; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona A; Monk, Kathryn A; Ockendon, Nancy; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C

    2015-01-01

    This paper presents the results of our sixth annual horizon scan, which aims to identify phenomena that may have substantial effects on the global environment, but are not widely known or well understood. A group of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics via an iterative, Delphi-like process. The topics include a novel class of insecticide compounds, legalisation of recreational drugs, and the emergence of a new ecosystem associated with ice retreat in the Antarctic.

  6. Optical Navigation Preparations for New Horizons Pluto Flyby

    NASA Technical Reports Server (NTRS)

    Owen, William M., Jr.; Dumont, Philip J.; Jackman, Coralie D.

    2012-01-01

    The New Horizons spacecraft will encounter Pluto and its satellites in July 2015. As was the case for the Voyager encounters with Jupiter, Saturn, Uranus and Neptune, mission success will depend heavily on accurate spacecraft navigation, and accurate navigation will be impossible without the use of pictures of the Pluto system taken by the onboard cameras. We describe the preparations made by the New Horizons optical navigators: picture planning, image processing algorithms, software development and testing, and results from in-flight imaging.

  7. Constrained field theories on spherically symmetric spacetimes with horizons

    NASA Astrophysics Data System (ADS)

    Fernandes, Karan; Lahiri, Amitabha; Ghosh, Suman

    2017-02-01

    We apply the Dirac-Bergmann algorithm for the analysis of constraints to gauge theories defined on spherically symmetric black hole backgrounds. We find that the constraints for a given theory are modified on such spacetimes through the presence of additional contributions from the horizon. As a concrete example, we consider the Maxwell field on a black hole background, and determine the role of the horizon contributions on the dynamics of the theory.

  8. A horizon scan of global conservation issues for 2013.

    PubMed

    Sutherland, William J; Bardsley, Sarah; Clout, Mick; Depledge, Michael H; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Margerison, Ceri; Monk, Kathryn A; Norris, Kenneth; Peck, Lloyd S; Prior, Stephanie V; Scharlemann, Jörn P W; Spalding, Mark D; Watkinson, Andrew R

    2013-01-01

    This paper presents the findings of our fourth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity. The 15 issues were identified via an iterative, transferable process by a team of professional horizon scanners, researchers, practitioners, and a journalist. The 15 topics include the commercial use of antimicrobial peptides, thorium-fuelled nuclear power, and undersea oil production.

  9. Black hole entropy from conformal symmetry on the horizon

    NASA Astrophysics Data System (ADS)

    Carlip, Steven

    2017-01-01

    The idea that black hole entropy might be governed by a conformal symmetry is an old one, but until now most efforts have focused on either asymptotic symmetries or symmetries on a ``stretched horizon. For two-dimensional dilaton gravity, I show the existence of a well-behaved conformal symmetry that is on the horizon, with a central charge that correctly determines the black hole entropy. Supported by Department of Energy grant DE-FG02-91ER40674.

  10. Reflection and transmission at the apparent horizon during gravitational collapse

    SciTech Connect

    Vaz, Cenalo; Wijewardhana, L. C. R.

    2010-10-15

    We examine the wave functionals describing the collapse of a self-gravitating dustball in an exact quantization of the gravity-dust system. We show that ingoing (collapsing) dust shell modes outside the apparent horizon must necessarily be accompanied by outgoing modes inside the apparent horizon, whose amplitude is suppressed by the square root of the Boltzmann factor at the Hawking temperature. Likewise, ingoing modes in the interior must be accompanied by outgoing modes in the exterior, again with an amplitude suppressed by the same factor. A suitable superposition of the two solutions is necessary to conserve the dust probability flux across the apparent horizon; thus, each region contains both ingoing and outgoing dust modes. If one restricts oneself to considering only the modes outside the apparent horizon then one should think of the apparent horizon as a partial reflector, the probability for a shell to reflect being given by the Boltzmann factor at the Hawking temperature determined by the mass contained within it. However, if one considers the entire wave function, the outgoing wave in the exterior is seen to be the transmission through the horizon of the interior outgoing wave that accompanies the collapsing shells. This transmission could allow information from the interior to be transferred to the exterior.

  11. Null infinity and extremal horizons in AdS-CFT

    NASA Astrophysics Data System (ADS)

    Hickling, Andrew; Lucietti, James; Wiseman, Toby

    2015-02-01

    We consider AdS gravity duals to CFT on background spacetimes with a null infinity. Null infinity on the conformal boundary may extend to an extremal horizon in the bulk. For example it does so for Poincaré-AdS, although does not for planar Schwarzschild-AdS. If null infinity does extend into an extremal horizon in the bulk, we show that the bulk near-horizon geometry is determined by the geometry of the boundary null infinity. Hence the ‘infra-red’ geometry of the bulk is fixed by the large scale behaviour of the CFT spacetime. In addition the boundary stress tensor must have a particular decay at null infinity. As an application, we argue that for CFT on asymptotically flat backgrounds, any static bulk dual containing an extremal horizon extending from the boundary null infinity, must have the near-horizon geometry of Poincaré-AdS. We also discuss a class of boundary null infinity that cannot extend to a bulk extremal horizon, although we give evidence that they can extend to an analogous null surface in the bulk which possesses an associated scale-invariant ‘near-geometry’.

  12. Rotating Killing horizons in generic F( R) gravity theories

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Sourav

    2016-10-01

    We discuss various properties of rotating Killing horizons in generic F( R) theories of gravity in dimension four for spacetimes endowed with two commuting Killing vector fields. Assuming there is no curvature singularity anywhere on or outside the horizon, we construct a suitable (3+1)-foliation. We show that similar to Einstein's gravity, we must have T_{ab}k^ak^b=0 on the Killing horizon, where k^a is a null geodesic tangent to the horizon. For axisymmetric spacetimes, the effective gravitational coupling ˜ F'^{-1}(R) should usually depend upon the polar coordinate and hence need not necessarily be a constant on the Killing horizon. We prove that the surface gravity of such a Killing horizon must be a constant, irrespective of whether F'(R) is a constant there or not. We next apply these results to investigate some further basic features. In particular, we show that any hairy solution for the real massive vector field in such theories is clearly ruled out, as long as the potential of the scalar field generated in the corresponding Einstein's frame is a positive definite quantity.

  13. Application of a Double Aza-Michael Reaction in a 'Click, Click, Cy-Click' Strategy: From Bench to Flow.

    PubMed

    Zang, Qin; Javed, Salim; Ullah, Farman; Zhou, Aihua; Knudtson, Christopher A; Bi, Danse; Basha, Fatima Z; Organ, Michael G; Hanson, Paul R

    2011-09-01

    The development of a 'click, click, cy-click' process utilizing a double aza-Michael reaction to generate functionalized 1,2,5-thiadiazepane 1,1-dioxides is reported. Optimization in flow, followed by scale out of the inter-/intramolecular double aza-Michael addition has also been realized using a microwave-assisted, continuous flow organic synthesis platform (MACOS). In addition, a facile one-pot, sequential strategy employing in situ Huisgen cycloaddition post-double aza-Michael has been accomplished, and is applicable to library synthesis.

  14. Generalized Robertson-Walker Space-Time Admitting Evolving Null Horizons Related to a Black Hole Event Horizon.

    PubMed

    Duggal, K L

    2016-01-01

    A new technique is used to study a family of time-dependent null horizons, called "Evolving Null Horizons" (ENHs), of generalized Robertson-Walker (GRW) space-time [Formula: see text] such that the metric [Formula: see text] satisfies a kinematic condition. This work is different from our early papers on the same issue where we used (1 + n)-splitting space-time but only some special subcases of GRW space-time have this formalism. Also, in contrast to previous work, we have proved that each member of ENHs is totally umbilical in [Formula: see text]. Finally, we show that there exists an ENH which is always a null horizon evolving into a black hole event horizon and suggest some open problems.

  15. Novel ionic liquid with both Lewis and Brønsted acid sites for Michael addition.

    PubMed

    Jiang, Xiaoyue; Ye, Weidong; Song, Xiaohua; Ma, Wenxin; Lao, Xuejun; Shen, Runpu

    2011-01-01

    Ionic liquid with both Lewis and Brønsted acid sites has been synthesized and its catalytic activities for Michael addition were carefully studied. The novel ionic liquid was stable to water and could be used in aqueous solution. The molar ratio of the Lewis and Brønsted acid sites could be adjusted to match different reactions. The results showed that the novel ionic liquid was very efficient for Michael addition with good to excellent yields within several min. Operational simplicity, high stability to water and air, small amount used, low cost of the catalyst used, high yields, chemoselectivity, applicability to large-scale reactions and reusability are the key features of this methodology, which indicated that this novel ionic liquid also holds great potential for environmentally friendly processes.

  16. Organocatalyzed asymmetric Michael addition by an efficient bifunctional carbohydrate-thiourea hybrid with mechanistic DFT analysis.

    PubMed

    Azad, Chandra S; Khan, Imran A; Narula, Anudeep K

    2016-12-28

    A series of thiourea based bifunctional organocatalysts having d-glucose as a core scaffold were synthesized and examined as catalysts for the asymmetric Michael addition reaction of aryl/alkyl trans-β-nitrostyrenes over cyclohexanone and other Michael donors having active methylene. Excellent enantioselectivities (<95%), diastereoselectivities (<99%), and yields (<99%) were attained under solvent free conditions using 10 mol% of 1d0. The obtained results were explained through DFT calculations using the B3LYP/6-311G(d,p)//B3LYP/6-31G(d) basic set. The QM/MM calculations revealed the role of cyclohexanone as a solvent as well as reactant in the rate determining step imparting 31.91 kcal mol(-1) of energy towards the product formation.

  17. Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition.

    PubMed

    Gutiérrez-Jiménez, Marta I; Aydillo, Carlos; Navo, Claudio D; Avenoza, Alberto; Corzana, Francisco; Jiménez-Osés, Gonzalo; Zurbano, María M; Busto, Jesús H; Peregrina, Jesús M

    2016-06-17

    A second generation of chiral bicyclic dehydroalanines easily accessible from serine has been developed. These scaffolds behaved as excellent S-Michael acceptors when tri-O-acetyl-2-acetamido-2-deoxy-1-thio-α-d-galactopyranose (abbreviated as GalNAc-α-SH) was used as a nucleophile. This addition proceeds with total chemo- and stereoselectivity, complete atom economy, quickly, and at room temperature, making it a true click reaction. The Michael adducts were easily transformed into S-(2-acetamido-2-deoxy-α-d-galactopyranosyl)-l- and -d-cysteines, which can be regarded as mimics of the Tn antigen derived from l-Ser (α-d-GalNAc-l-Ser) and d-Ser (α-d-GalNAc-d-Ser), respectively.

  18. Bifunctional Iminophosphorane Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α-Substituted Acrylate Esters.

    PubMed

    Farley, Alistair J M; Sandford, Christopher; Dixon, Darren J

    2015-12-30

    The highly enantioselective sulfa-Michael addition of alkyl thiols to unactivated α-substituted acrylate esters catalyzed by a bifunctional iminophosphorane organocatalyst under mild conditions is described. The strong Brønsted basicity of the iminophosphorane moiety of the catalyst provides the necessary activation of the alkyl thiol pro-nucleophile, while the two tert-leucine residues flanking a central thiourea hydrogen-bond donor facilitate high enantiofacial selectivity in the protonation of the transient enolate intermediate. The reaction is broad in scope with respect to the alkyl thiol, the ester moiety, and the α-substituent of the α,β-unsaturated ester, affords sulfa-Michael adducts in excellent yields (up to >99%) and enantioselectivities (up to 96% ee), and is amenable to decagram scale-up using catalyst loadings as low as 0.05 mol %.

  19. Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    PubMed

    2011-11-01

    Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved).

  20. Comparative Studies of Cathodically-Promoted and Base-Catalyzed Michael Addition Reactions of Levoglucosenone.

    PubMed

    Samet, Alexander V.; Niyazymbetov, Murat E.; Semenov, Victor V.; Laikhter, Andrei L.; Evans, Dennis H.

    1996-12-13

    Regioselective Michael addition of nitro and heterocyclic compounds to levoglucosenone, 1, is effectively catalyzed by amines and also by cathodic electrolysis. In comparison to the base-catalyzed reaction, it was found that under electrochemical conditions the reaction proceeds under milder conditions and with higher yields. Cathodically-initiated Michael addition of thiols to levoglucosenone using small currents produces the previously unknown threo addition product in several instances. The normal erythro isomer, identified as the kinetic product, tends to be formed when large currents are used. In contrast, slow, low current electrolyses promote equilibration of the two forms so that erythro can be converted to threo by the retro reaction and readdition. Addition of 2-naphthalenethiol to (R)-(+)-apoverbenone is also reported.

  1. [An exceptional human relationship (Michael P. Kierkegaard, Søren Kierkegaard)].

    PubMed

    Jacobs, R

    1978-01-01

    There were a father and a son, Michael and Sören Kierkegaard, both highly talented, imaginitive, witty, humorous, especially interested in shrewd dialectrical dialogues respectively debates, both profound melancholy ponderers. But according to very own individuality their congeniality wasn't absolute. The father, being under a questionable rigorous opinion of sin, suffered from undeserved divine grace since early childhood. And Michael Kierkegaard made Sören anxious with the religious experience of original sin. This anxiety moved (touched or affected) the sensitive son mighty. Nevertheless he should not despair hopelessly like his unlucky father. On the contrary: Sørens incomparable melancholy, mental agony and anxiety (fear or anguish) forced the faith, existing independently of them, in a radical refining. That is why Sören Kierkegaard succeeded in sublimation of all psychological and philosophic (al) attitudes (or opinions) in the sphere of religiousness. And the result? A novel philosophy of life: Christian existentialism.

  2. Methylthiodeoxynivalenol (MTD): insight into the chemistry, structure and toxicity of thia-Michael adducts of trichothecenes.

    PubMed

    Fruhmann, Philipp; Weigl-Pollack, Theresa; Mikula, Hannes; Wiesenberger, Gerlinde; Adam, Gerhard; Varga, Elisabeth; Berthiller, Franz; Krska, Rudolf; Hametner, Christian; Fröhlich, Johannes

    2014-07-28

    Methylthiodeoxynivalenol (MTD), a novel derivative of the trichothecene mycotoxin deoxynivalenol (DON), was prepared by applying a reliable procedure for the formal Michael addition of methanethiol to the conjugated double bond of DON. Structure elucidation revealed the preferred formation of the hemiketal form of MTD by intramolecular cyclisation between C8 and C15. Computational investigations showed a negative total reaction energy for the hemiketalisation step and its decrease in comparison with theoretical model compounds. Therefore, this structural behaviour seems to be a general characteristic of thia-Michael adducts of type B trichothecenes. MTD was shown to be less inhibitory for a reticulocyte lysate based in vitro translation system than the parent compound DON, which supports the hypothesis that trichothecenes are detoxified through thia-adduct formation during xenobiotic metabolism.

  3. Reagent-based, modular, tandem Michael approach for obtaining different indoline alkaloid-inspired polycyclic architectures.

    PubMed

    Brochu, Jean-Louis; Prakesch, Michael; Enright, Gary D; Leek, Donald M; Arya, Prabhat

    2008-01-01

    A modular, reagent-based approach to obtain different indoline alkaloid-inspired, tetracyclic architectures is developed. With the use of TBSOTf as a Lewis acid, we report here a tandem Michael-based approach that led to the synthesis of a diastereomeric mixture of tetracyclic derivatives with two additional six-membered rings. By simply changing the Lewis acid to TMSOTf, we were able to obtain a different tetracyclic compound having additional functionalized 5- and 7-membered rings with complete stereocontrol.

  4. Stereodivergent organocatalytic intramolecular Michael addition/lactonization for the asymmetric synthesis of substituted dihydrobenzofurans and tetrahydrofurans.

    PubMed

    Belmessieri, Dorine; de la Houpliere, Alix; Calder, Ewen D D; Taylor, James E; Smith, Andrew D

    2014-07-28

    A stereodivergent asymmetric Lewis base catalyzed Michael addition/lactonization of enone acids into substituted dihydrobenzofuran and tetrahydrofuran derivatives is reported. Commercially available (S)-(-)-tetramisole hydrochloride gives products with high syn diastereoselectivity in excellent enantioselectivity (up to 99:1 d.r.syn/anti , 99 % eesyn ), whereas using a cinchona alkaloid derived catalyst gives the corresponding anti-diastereoisomers as the major product (up to 10:90 d.r.syn/anti , 99 % eeanti ).

  5. Michael's Marathon: My Experience of Overcoming Illiteracy as an Adult. Literacy Lessons.

    ERIC Educational Resources Information Center

    Marquet, Michael

    Michael Marquet of New Zealand left school 10 years ago, not able to read or write and with a serious speech problem. He had spent 9 years in a special class and had learned very little. He had completed 2 years of high school and left at the end of the fourth form, at the age of 15 and with no qualifications. However, he had participated in a…

  6. Chiral N,N'-Dioxide-Organocatalyzed Regio-, Diastereo- and Enantioselective Michael Addition-Alkylation Reaction.

    PubMed

    Feng, Juhua; Yuan, Xiao; Luo, Weiwei; Lin, Lili; Liu, Xiaohua; Feng, Xiaoming

    2016-10-24

    A highly regio-, diastereo- and enantioselective Michael addition-alkylation reaction between α-substituted cyano ketones and (Z)-bromonitrostyrenes has been realized by using a chiral N,N'-dioxide as organocatalyst. A variety of substrates performed well in this reaction, and the corresponding multifunctionalized chiral 2,3-dihydrofurans were obtained in up to 95 % yield with 95:5 dr and 93 % ee.

  7. L-Proline Derived Bifunctional Organocatalysts: Enantioselective Michael Addition of Dithiomalonates to trans-β-Nitroolefins.

    PubMed

    Jin, Hui; Kim, Seung Tae; Hwang, Geum-Sook; Ryu, Do Hyun

    2016-04-15

    A series of novel L-proline derived tertiary amine bifunctional organocatalysts 9 are reported, which were applied to the asymmetric Michael addition of dithiomalonates 2 to trans-β-nitroolefins 1. The reaction proceeded in high yields (up to 99%) with high enantioselectivities (up to 97% ee). The synthetic utility of this methodology was demonstrated in the short synthesis of (R)-phenibut in high yield.

  8. Organocatalytic asymmetric Michael addition of unprotected 3-substituted oxindoles to 1,4-naphthoquinone

    PubMed Central

    Yu, Jin-Sheng; Zhou, Feng; Liu, Yun-Lin

    2012-01-01

    Summary We reported the first example of organocatalytic Michael addition of unprotected 3-prochiral oxindoles 1 to 1,4-naphthoquinone. Quinidine derivative (DHQD)2PYR was found to be able to catalyze this reaction in up to 83% ee, with moderate to excellent yields. This method could be used for the synthesis of enantioenriched 3,3-diaryloxindoles, and the catalytic synthesis of which was unprecedented. PMID:23019472

  9. Functionalized 3D Architected Materials via Thiol-Michael Addition and Two-Photon Lithography.

    PubMed

    Yee, Daryl W; Schulz, Michael D; Grubbs, Robert H; Greer, Julia R

    2017-02-20

    Fabrication of functionalized 3D architected materials is achieved by a facile method using functionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using two-photon lithography. A wide variety of functional groups can be attached, from Boc-protected amines to fluoroalkanes. Modification of surface wetting properties and conjugation with fluorescent tags are demonstrated to highlight the potential applications of this technique.

  10. Highlighting High Performance: Michael E. Capuano Early Childhood Center; Somerville, Massachusetts

    SciTech Connect

    Not Available

    2006-03-01

    This brochure describes the key high-performance building features of the Michael E. Capuano Early Childhood Center. The brochure was paid for by the Massachusetts Technology Collaborative as part of their Green Schools Initiative. High-performance features described are daylighting and energy-efficient lighting, indoor air quality, solar and wind energy, building envelope, heating and cooling systems, water conservation, and acoustics. Energy cost savings are also discussed.

  11. Group 12, 1987 ASCAN C. Michael Foale sits at the pilots station in JSC's FFT

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Group 12, 1987 Astronaut Candidate (ASCAN) C. Michael Foale sits at the forward flight deck pilots station controls in JSC's Full Fuselage Trainer (FFT). The FFT is used to familiarize the astronauts with the hardware in the cockpit of the Space Shuttle orbiters. It is one of the mockup training devices located in the Mockup and Integration Laboratory (MAIL) Bldg 9NE. Foale is one of 15 ASCANs recently selected by NASA.

  12. Deracemizing organocatalyzed Michael addition reactions of 2-(arylthio)cyclobutanones with β-nitrostyrenes.

    PubMed

    Luridiana, Alberto; Frongia, Angelo; Aitken, David J; Guillot, Regis; Sarais, Giorgia; Secci, Francesco

    2016-04-07

    Organocatalyzed Michael addition reactions of 2-(arylthio)cyclobutanones with trans-β-nitrostyrenes have been carried out using a bifunctional thiourea-primary amine catalyst, providing diastereoisomerically and enantiomerically enriched 2-alkyl-2-(arylthio)cyclobutanones having two contiguous stereocenters of which one is a chiral quaternary center. The absolute configuration of these novel adducts was assigned by X-ray diffraction analysis and a transition-state model is proposed to explain the observed stereoselectivities.

  13. Nitroxide polymer networks formed by Michael addition: on site-cured electrode-active organic coating.

    PubMed

    Ibe, Takeshi; Frings, Rainer B; Lachowicz, Artur; Kyo, Soichi; Nishide, Hiroyuki

    2010-05-28

    Highly and homogeneously crosslinked poly(beta-ketoester) networks densely bearing robust nitroxide radicals were prepared via a click-type and stepwise Michael polyaddition. A half-battery cell composed of the thermally-cured radical network coatings displayed a rapid, reversible, and almost stoichiometric redox-activity even with a thickness of ca. 10 mum, which may be applicable as the electrode of organic-based rechargeable devices.

  14. Michael addition-elimination reactions of chiral enolates with ethyl 3-halopropenoates.

    PubMed

    Esteban, Jorge; Costa, Anna M; Gómez, Alex; Vilarrasa, Jaume

    2008-01-03

    Key dienoic or dienal substructures of cytotoxic macrolides amphidinolide E and dictyostatin have been prepared via a Michael addition (followed by elimination of X-) of chiral enolates on beta-halo derivatives of ethyl acrylate, with full retention of the initial E or Z configuration. Evans oxazolidin-2-ones and our related thiazolidin-2-ones, as well as a fine-tuning of the reaction conditions, have been essential. Many chiral building blocks are accessible from these adducts.

  15. Catalytic enantioselective Michael additions to unsaturated ester derivatives using chiral copper(II) Lewis acid complexes.

    PubMed

    Evans, D A; Willis, M C; Johnston, J N

    1999-09-23

    [formula: see text] Chiral Cu(II) bisoxazoline (box) Lewis acids have been developed as catalysts of the Michael addition of enolsilanes to unsaturated ester derivatives. While enantioselection is stereoregular, the sense of diastereoselection is directly related to thioester enolsilane geometry: (E) enolsilanes give anti adducts and (Z) enolsilanes afford syn adducts. The size of the enolsilane alkylthio substituent directly impacts the magnitude of diastereoselection.

  16. Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus.

    PubMed

    Wang, Fenghua; Chen, Cheng; Yang, Kailin; Xu, Yang; Liu, Xiaomei; Gao, Fan; Liu, He; Chen, Xia; Zhao, Qi; Liu, Xiang; Cai, Yan; Yang, Haitao

    2017-03-13

    Porcine epidemic diarrhea virus (PEDV) causes high mortality in pigs. PEDV main protease (Mpro) plays an essential role in viral replication. We solved the structure of PEDV Mpro complexed with peptidomimetic inhibitor N3 carrying a Michael acceptor warhead, revealing atomic level interactions. We further designed a series of 17 inhibitors with altered side groups. Inhibitors M2 and M17 demonstrated enhanced specificity against PEDV Mpro. These compounds have potential as future therapeutics to combat PEDV infection.

  17. Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents.

    PubMed

    Ettari, Roberta; Previti, Santo; Cosconati, Sandro; Maiorana, Santina; Schirmeister, Tanja; Grasso, Silvana; Zappalà, Maria

    2016-08-01

    Novel 1,4-benzodiazepines, endowed with a Michael acceptor moiety, were designed taking advantage of a computational prediction of their pharmacokinetic parameters. Among all the synthesized derivatives, we identified a new lead compound (i.e., 4a), bearing a vinyl ketone warhead and endowed with a promising antitrypanosomal activity against Trypanosoma brucei brucei (IC50=5.29μM), coupled with a lack of cytotoxicity towards mammalian cells (TC50 >100μM).

  18. Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations.

    PubMed

    Mulliner, Denis; Wondrousch, Dominik; Schüürmann, Gerrit

    2011-12-21

    The electrophilic reactivity of Michael acceptors is an important determinant of their toxicity. For a set of 35 α,β-unsaturated aldehydes, ketones and esters with experimental rate constants of their reaction with glutathione (GSH), k(GSH), quantum chemical transition-state calculations of the corresponding Michael addition of the model nucleophile methane thiol (CH(3)SH) have been performed at the B3LYP/6-31G** level, focusing on the 1,2-olefin addition pathway without and with initial protonation. Inclusion of Boltzmann-weighting of conformational flexibility yields intrinsic reaction barriers ΔE(‡) that for the case of initial protonation correctly reflect the structural variation of k(GSH) across all three compound classes, except that they fail to account for a systematic (essentially incremental) decrease in reactivity upon α-substitution. By contrast, the reduction in k(GSH) through β-substitution is well captured by ΔE(‡). Empirical correction for the α-substitution effect yields a high squared correlation coefficient (r(2) = 0.96) for the quantum chemical prediction of log k(GSH), thus enabling an in silico screening of the toxicity-relevant electrophilicity of α,β-unsaturated carbonyls. The latter is demonstrated through application of the calculation scheme for a larger set of 46 Michael-acceptor aldehydes, ketones and esters with experimental values for their toxicity toward the ciliates Tetrahymena pyriformis in terms of 50% growth inhibition values after 48 h exposure (EC(50)). The developed approach may add in the predictive hazard evaluation of α,β-unsaturated carbonyls such as for the European REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) Directive, enabling in particular an early identification of toxicity-relevant Michael-acceptor reactivity.

  19. STS-69 MS Michael L. Gernhardt greets his mother at SLF

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-69 Mission Specialist Michael L. Gernhardt (right) gets a chance to say hi to his mother, Suzanne Winters, and her husband Doug, after the STS-69 flight crew arrived at KSC's Shuttle Landing Facility. The five astronauts assigned to the mission are looking forward to a liftoff aboard the Space Shuttle Endeavour during a two and a half hour window opening at 11:09 a.m. EDT, Sept. 7.

  20. Black holes or firewalls: A theory of horizons

    NASA Astrophysics Data System (ADS)

    Nomura, Yasunori; Varela, Jaime; Weinberg, Sean J.

    2013-10-01

    We present a quantum theory of black hole (and other) horizons, in which the standard assumptions of complementarity are preserved without contradicting information theoretic considerations. After the scrambling time, the quantum mechanical structure of a black hole becomes that of an eternal black hole at the microscopic level. In particular, the stretched horizon degrees of freedom and the states entangled with them can be mapped into the near-horizon modes in the two exterior regions of an eternal black hole, whose mass is taken to be that of the evolving black hole at each moment. Salient features arising from this picture include (i) the number of degrees of freedom needed to describe a black hole is eA/2lP2, where A is the area of the horizon; (ii) black hole states having smooth horizons, however, span only an eA/4lP2-dimensional subspace of the relevant eA/2lP2-dimensional Hilbert space; (iii) internal dynamics of the horizon is such that an infalling observer finds a smooth horizon with a probability of 1 if a state stays in this subspace. We identify the structure of local operators responsible for describing semiclassical physics in the exterior and interior spacetime regions and show that this structure avoids the arguments for firewalls—the horizon can keep being smooth throughout the evolution. We discuss the fate of infalling observers under various circumstances, especially when the observers manipulate degrees of freedom before entering the horizon, and we find that an observer can never see a firewall by making a measurement on early Hawking radiation. We also consider the presented framework from the viewpoint of an infalling reference frame and argue that Minkowski-like vacua are not unique. In particular, the number of true Minkowski vacua is infinite, although the label discriminating these vacua cannot be accessed in usual nongravitational quantum field theory. An application of the framework to de Sitter horizons is also discussed.

  1. Nickel(II)-Catalyzed Cascade Vinylogous Mukaiyama 1,6-Michael/Michael Addition of 2-Silyloxyfuran with N-Sulfonyl-1-aza-1,3-dienes: Access to Fused Piperidine/Butyrolactone Skeletons.

    PubMed

    Liu, Kang; Chang, Xin; Wang, Chun-Jiang

    2016-12-16

    An unprecedented and highly efficient nickel-catalyzed cascade vinylogous Mukaiyama 1,6-Michael/Michael addition of 2-silyloxyfuran with N-sulfonyl-1-aza-1,3-dienes is reported, in which 2-silyloxyfuran was successfully employed as nucleophile and electrophile sequentially. This methodology combined with subsequent reduction provides a facile access to biologically important fused piperidine/butyrolactone skeletons in good yield with exclusive diastereoselectivity under mild reaction conditions.

  2. A celebration of mechanics: from nano to macro. The J. Michael T. Thompson Festschrift issue.

    PubMed

    Elishakoff, Isaac

    2013-06-28

    This Theme Issue is dedicated to the topic 'Mechanics: from nano to macro' and marks the 75th birthday of Dr J. Michael T. Thompson, Fellow of the Royal Society, whose current affiliations are as follows: (i) Honorary Fellow, Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge; (ii) Emeritus Professor of Nonlinear Dynamics, Department of Civil, Environmental and Geomatic Engineering, University College London; and (iii) Professor of Theoretical and Applied Dynamics (Distinguished Sixth Century Chair, part-time), University of Aberdeen. He also serves as Chairman of the Board of Directors at ES-Consult (consulting engineers) in Copenhagen, Denmark. The pertinent question that arises from the very start is: should we first salute Michael and then describe the Theme Issue, or vice versa? Indeed, according to Blaise Pascal (1623-1662), the last thing one discovers in composing a work is what to put first. I would like to take the liberty of deviating from the tradition of the Philosophical Transactions and start with the tribute to Michael; after all he is the prime cause of this Theme Issue.

  3. An examination of possible mass burials in Pensacola, Florida's historic St. Michael's Cemetery

    NASA Astrophysics Data System (ADS)

    Rosenberg Marshall, Nicole Marie

    St. Michael's Cemetery is the oldest extant cemetery in Pensacola, Florida. St. Michael's Cemetery is also one of the two oldest cemeteries in Florida (the other being located in St. Augustine). Since 2000, the University of West Florida (UWF) has been engaged in ongoing research at the cemetery. Historical records indicate that a significant unmarked burial population may be present within the cemetery. In 2007 and 2008, a systematic Ground Penetrating Radar (GPR) survey identified 3,915 sub-surface anomalies that may represent unmarked burials. Some of these anomalies are significantly larger than would be expected for single interments and potentially represent mass burials from colonial and post-colonial period epidemic events. To test this hypothesis, excavations were conducted at three of the five large anomalies during 2009, 2010, and 2011. The goals of these investigations were to determine whether the sub-surface anomalies represent mass interments and to determine the chronology and ethnicity of any individual burials encountered using grave attributes and associated artifacts. While none of the anomalies excavated were mass graves, several individual unmarked burials were exposed and documented. This thesis summarizes the methods, results, and conclusions of the research conducted in St. Michael's Cemetery while contextualizing them within previous research.

  4. Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes.

    PubMed

    Evans, D A; Scheidt, K A; Johnston, J N; Willis, M C

    2001-05-16

    The scope of highly enantioselective and diastereoselective Michael additions of enolsilanes to unsaturated imide derivatives has been developed with use of [Cu((S,S)-t-Bu-box)](SbF6)2 (1a) as a Lewis acid catalyst. The products of these additions are useful synthons that contain termini capable of differentiation under mild conditions. Michael acceptor pi-facial selectivity is consistent with two-point binding of the imide substrate and can be viewed as an extension of substrate enantioselection in the corresponding Diels-Alder reactions. A model analogous to the one employed to describe the hetero Diels-Alder reaction is proposed to account for the observed relation between enolsilane geometry and product absolute diastereocontrol. Insights into modes of catalyst inactivation are given, including spectroscopic evidence for inhibition of the catalyst by a dihydropyran intermediate that evolves during the course of the reaction. A procedure is disclosed in which an alcohol additive is used to hydrolyze the inhibiting dihydropyran and afford the desilylated Michael adduct in significantly shortened reaction time.

  5. Io’s active volcanoes during the New Horizons era: Insights from New Horizons imaging

    NASA Astrophysics Data System (ADS)

    Rathbun, J. A.; Spencer, J. R.; Lopes, R. M.; Howell, R. R.

    2014-03-01

    In February 2007, the New Horizons spacecraft flew by the Jupiter system, obtaining images of Io, the most volcanically active body in the Solar System. The Multicolor Visible Imaging Camera (MVIC), a four-color (visible to near infrared) camera, obtained 17 sets of images. The Long-Range Reconnaissance Imager (LORRI), a high-resolution panchromatic camera, obtained 190 images, including many of Io eclipsed by Jupiter. We present a complete view of the discrete point-like emission sources in all images obtained by these two instruments. We located 54 emission sources and determined their brightnesses. These observations, the first that observed individual Ionian volcanoes on short timescales of seconds to minutes, demonstrate that the volcanoes have stable brightnesses on these timescales. The active volcanoes Tvashtar (63N, 124W) and E. Girru (22N, 245W) were observed by both LORRI and MVIC, both in the near-infrared (NIR) and methane (CH4) filters. Tvashtar was additionally observed in the red filter, which allowed us to calculate a color temperature of approximately 1200 K. We found that, with some exceptions, most of the volcanoes frequently active during the Galileo era continued to be active during the New Horizons flyby. We found that none of the seven volcanoes observed by New Horizons multiple times over short timescales showed substantial changes on the order of seconds and only one, E. Girru exhibited substantial variation over minutes to days, increasing by 25% in just over an hour and decreasing by a factor of 4 over 6 days. Observations of Tvashtar are consistent with a current eruption similar to previously observed eruptions and are more consistent with the thermal emission of a lava flow than the fire fountains inferred from the November 1999 observations. These data also present new puzzles regarding Ionian volcanism. Since there is no associated surface change or low albedo feature that could be identified nearby, the source of the emission from

  6. Visible-Light-Initiated Thiol-Michael Addition Polymerizations with Coumarin-Based Photobase Generators: Another Photoclick Reaction Strategy.

    PubMed

    Zhang, Xinpeng; Xi, Weixian; Wang, Chen; Podgórski, Maciej; Bowman, Christopher N

    2016-02-16

    An efficient visible-light-sensitive photobase generator for thiol-Michael addition reactions was synthesized and evaluated. This highly reactive catalyst was designed by protecting a strong base (tetramethyl guanidine, TMG) with a visible-light-responsive group which was a coumarin derivative. The coumarin-coupled TMG was shown to exhibit extraordinary catalytic activity toward initiation of the thiol-Michael reaction, including thiol-Michael addition-based polymerization, upon visible-light irradiation, leading to a stoichiometric reaction of both thiol and vinyl functional groups. Owing to its features, this visible-light photobase generator enables homogeneous network formation in thiol-Michael polymerizations and also has the potential to be exploited in other visible-light-induced, base-catalyzed thiol-click processes such as thiol-isocynate and thiol-epoxy network-forming reactions.

  7. Surface Modified Particles By Multi-Step Michael-Type Addition And Process For The Preparation Thereof

    SciTech Connect

    Cook, Ronald Lee; Elliott, Brian John; Luebben, Silvia DeVito; Myers, Andrew William; Smith, Bryan Matthew

    2005-05-03

    A new class of surface modified particles and a multi-step Michael-type addition surface modification process for the preparation of the same is provided. The multi-step Michael-type addition surface modification process involves two or more reactions to compatibilize particles with various host systems and/or to provide the particles with particular chemical reactivities. The initial step comprises the attachment of a small organic compound to the surface of the inorganic particle. The subsequent steps attach additional compounds to the previously attached organic compounds through reactive organic linking groups. Specifically, these reactive groups are activated carbon—carbon pi bonds and carbon and non-carbon nucleophiles that react via Michael or Michael-type additions.

  8. Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis.

    PubMed

    Zhang, Yan; Vongvilai, Pornrapee; Sakulsombat, Morakot; Fischer, Andreas; Ramström, Olof

    2014-03-24

    Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.

  9. Rh(III)-Catalyzed C-H Bond Addition/Amine-Mediated Cyclization of Bis-Michael Acceptors.

    PubMed

    Potter, Tyler J; Ellman, Jonathan A

    2016-08-05

    A Rh(III)-catalyzed C-H bond addition/primary amine-promoted cyclization of bis-Michael acceptors is reported. The C-H bond addition step occurs with high chemoselectivity, and the subsequent intramolecular Michael addition, mediated by a primary amine catalyst, sets three contiguous stereocenters with high diastereoselectivity. A broad range of directing groups and both aromatic and alkenyl C-H bonds were shown to be effective in this transformation, affording functionalized piperidines, tetrahydropyrans, and cyclohexanes.

  10. Human knockout research: new horizons and opportunities.

    PubMed

    Alkuraya, Fowzan S

    2015-02-01

    Although numerous approaches have been pursued to understand the function of human genes, Mendelian genetics has by far provided the most compelling and medically actionable dataset. Biallelic loss-of-function (LOF) mutations are observed in the majority of autosomal recessive Mendelian disorders, representing natural human knockouts and offering a unique opportunity to study the physiological and developmental context of these genes. The restriction of such context to 'disease' states is artificial, however, and the recent ability to survey entire human genomes for biallelic LOF mutations has revealed a surprising landscape of knockout events in 'healthy' individuals, sparking interest in their role in phenotypic diversity beyond disease causation. As I discuss in this review, the potentially wide implications of human knockout research warrant increased investment and multidisciplinary collaborations to overcome existing challenges and reap its benefits.

  11. Genesis of petroduric and petrocalcic horizons in Latinamerica volcanic soils

    NASA Astrophysics Data System (ADS)

    Quantin, Paul

    2010-05-01

    Introduction. In Latinamerica, from Mexico to Chile, there are indurated volcanic soils horizons, named 'tepetate' in Mexico or cangahua in the Andes Mountains. Apart from original volcanic tuffs, these horizons were produced by pedogenesis: either through a former weathering of volcanic ash layers into fragic and later to petrocalcic horizons; or after a former soil formation through a second process of transformation from clayey volcanic soils to silicified petroduric horizons. This oral presentation will briefly deal with the formation of petroduric horizons in Mexico and petrocalcic horizon in Ecuador. Petroduric horizon genesis in Mexico. A soil climato-toposequence, near to Veracruz (Rossignol & Quantin, 1997), shows downwards an evolution from a ferralic Nitisol to a petroduric Durisol. A Durisol profile comports these successive horizons: at the top A and Eg, then columnar Btg-sim, laminar Bt-sim , prismatic Bsim, plinthite Cg, over andesite lava flow. Among its main features are especially recorded: clay mineralogy, microscopy and HRTEM. These data show: an increase in cristobalite at the expenses of 0.7 nm halloysite in Egsiltans, laminar Bt-sim, around or inside the columns or prisms of Btg-sim and Bsimhorizons. HRTEM (Elsass & al 2000) on ultra thin sections reveals an 'epigenesis' of clay sheets by amorphous silica, to form successively A-opal, Ct-opal and microcrystalline cristobalite. From these data and some groundwater chemical analyses, a scenario of duripan formation from a past clayey Nitisol is inferred: clay eluviation-illuviation process? alternate redoximorphy? clay degradation, Al leaching and Si accumulation, to form successively A-opal, Ct-opal and cristobalite. Petrocalcic horizon genesis in Ecuador. A soil climato-toposequence on pyroclastic flows, near to Bolivar in Ecuador (Quantin & Zebrowski, 1997), shows downwards the evolution from fragic-eutric-vitric Cambisols to petrocalcic-vitric Phaeozems, at the piedmont under semi

  12. Beyond the veil: Inner horizon instability and holography

    SciTech Connect

    Balasubramanian, Vijay; Levi, Thomas S.

    2004-11-15

    We show that scalar perturbations of the eternal, rotating Banados-Teitelboim-Zanelli (BTZ) black hole should lead to an instability of the inner (Cauchy) horizon, preserving strong cosmic censorship. Because of backscattering from the geometry, plane-wave modes have a divergent stress tensor at the event horizon, but suitable wave packets avoid this difficulty, and are dominated at late times by quasinormal behavior. The wave packets have cuts in the complexified coordinate plane that are controlled by requirements of continuity, single-valuedness, and positive energy. Due to a focusing effect, regular wave packets nevertheless have a divergent stress energy at the inner horizon, signaling an instability. We propose that this instability, which is localized behind the event horizon, is detected holographically as a breakdown in the semiclassical computation of dual conformal field theory (CFT) expectation values in which the analytic behavior of wave packets in the complexified coordinate plane plays an integral role. In the dual field theory, this is interpreted as an encoding of physics behind the horizon in the entanglement between otherwise independent CFTs.

  13. Dark energy in thermal equilibrium with the cosmological horizon?

    NASA Astrophysics Data System (ADS)

    Poitras, Vincent

    2014-03-01

    According to a generalization of black hole thermodynamics to a cosmological framework, it is possible to define a temperature for the cosmological horizon. The hypothesis of thermal equilibrium between the dark energy and the horizon has been considered by many authors. We find the restrictions imposed by this hypothesis on the energy transfer rate (Qi) between the cosmological fluids, assuming that the temperature of the horizon has the form T =b/2πR, where R is the radius of the horizon. We more specifically consider two types of dark energy: Chaplygin gas (CG) and dark energy with a constant equation of state parameter (wDE). In each case, we show that for a given radius R, there is a unique term Qde that is consistent with thermal equilibrium. We also consider the situation where, in addition to dark energy, other fluids (cold matter, radiation) are in thermal equilibrium with the horizon. We find that the interaction terms required for this will generally violate energy conservation (∑iQi=0).

  14. Universality of P - V criticality in horizon thermodynamics

    NASA Astrophysics Data System (ADS)

    Hansen, Devin; Kubizňák, David; Mann, Robert B.

    2017-01-01

    We study P - V criticality of black holes in Lovelock gravities in the context of horizon thermodynamics. The corresponding first law of horizon thermodynamics emerges as one of the Einstein-Lovelock equations and assumes the universal (independent of matter content) form δ E = T δ S - P δ V , where P is identified with the total pressure of all matter in the spacetime (including a cosmological constant Λ if present). We compare this approach to recent advances in extended phase space thermodynamics of asymptotically AdS black holes where the `standard' first law of black hole thermodynamics is extended to include a pressure-volume term, where the pressure is entirely due to the (variable) cosmological constant. We show that both approaches are quite different in interpretation. Provided there is sufficient non-linearity in the gravitational sector, we find that horizon thermodynamics admits the same interesting black hole phase behaviour seen in the extended case, such as a Hawking-Page transition, Van der Waals like behaviour, and the presence of a triple point. We also formulate the Smarr formula in horizon thermodynamics and discuss the interpretation of the quantity E appearing in the horizon first law.

  15. Fractal markets: Liquidity and investors on different time horizons

    NASA Astrophysics Data System (ADS)

    Li, Da-Ye; Nishimura, Yusaku; Men, Ming

    2014-08-01

    In this paper, we propose a new agent-based model to study the source of liquidity and the “emergent” phenomenon in financial market with fractal structure. The model rests on fractal market hypothesis and agents with different time horizons of investments. What is interesting is that though the agent-based model reveals that the interaction between these heterogeneous agents affects the stability and liquidity of the financial market the real world market lacks detailed data to bring it to light since it is difficult to identify and distinguish the investors with different time horizons in the empirical approach. results show that in a relatively short period of time fractal market provides liquidity from investors with different horizons and the market gains stability when the market structure changes from uniformity to diversification. In the real world the fractal structure with the finite of horizons can only stabilize the market within limits. With the finite maximum horizons, the greater diversity of the investors and the fractal structure will not necessarily bring more stability to the market which might come with greater fluctuation in large time scale.

  16. Beyond the veil: Inner horizon instability and holography

    NASA Astrophysics Data System (ADS)

    Balasubramanian, Vijay; Levi, Thomas S.

    2004-11-01

    We show that scalar perturbations of the eternal, rotating Banados-Teitelboim-Zanelli (BTZ) black hole should lead to an instability of the inner (Cauchy) horizon, preserving strong cosmic censorship. Because of backscattering from the geometry, plane-wave modes have a divergent stress tensor at the event horizon, but suitable wave packets avoid this difficulty, and are dominated at late times by quasinormal behavior. The wave packets have cuts in the complexified coordinate plane that are controlled by requirements of continuity, single-valuedness, and positive energy. Due to a focusing effect, regular wave packets nevertheless have a divergent stress energy at the inner horizon, signaling an instability. We propose that this instability, which is localized behind the event horizon, is detected holographically as a breakdown in the semiclassical computation of dual conformal field theory (CFT) expectation values in which the analytic behavior of wave packets in the complexified coordinate plane plays an integral role. In the dual field theory, this is interpreted as an encoding of physics behind the horizon in the entanglement between otherwise independent CFTs.

  17. Kepler's teacher Michael Mästlin and his textbook of astronomy (1582). (German Title: Keplers Lehrer Michael Mästlin und sein Lehrbuch der Astronomie (1582))

    NASA Astrophysics Data System (ADS)

    Rex, Friedemann

    In contrast to Andreas Libavius, Mästlin's contemporary in the field of chemistry, whose importance lies less in his ``Spiritus fumans Libavii'' (tin tetrachloride), and rather in his authorship of the first highly regarded chemical textbook, Michael Mästlin's renown as a convinced Copernican certainly does not rest upon his role as the author of a traditional astronomical textbook. Nevertheless, Mästlin convincingly demonstrates his didactic skills in his textbook, which not without reason ran through seven editions within a timespan of 42 years. To the benefit of all conscientious readers he readily fulfils the promises made in his opening comments, and an initiation in Mästlin's ``catechism'' of astronomy may indeed serve as a direct introduction of this esteemed teacher of Johannes Kepler.

  18. Review of the OSHA-NIOSH Response to the Deepwater Horizon Oil Spill: Protecting the Health and Safety of Cleanup Workers

    PubMed Central

    Michaels, David; Howard, John

    2012-01-01

    Introduction: The fire and explosion of the Deepwater Horizon oil rig resulted in an enormous oil spill that threatened large distances of coastline. The overall response was led by the United States Coast Guard and involved the oil company BP, federal agencies, and state and local governments of five states. Methods: The Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health focused extensive resources on ensuring that BP and its contractors provided safe working conditions for thousands of workers involved in the response. Federal personnel visited worksites daily, identifying hazards and means of abatement; assessed training programs to ensure that workers were adequately trained in languages they could understand; monitored chemical exposures and determined that the proper personal protective equipment was deployed; insisted on implementation of a heat mitigation program; rostered thousands of workers; and conducted extensive outreach in communities impacted by the spill. Results: Advance planning, immediate deployment, and collaboration across agencies helped ensure that the response operations resulted in no worker fatalities, and relatively few injuries and illnesses. Conclusions: For future responses, improvements should be made in how safety and health information, as well as the process behind safety and health decisions, are communicated to the public. Citation: Michaels D, Howard J. Review of the OSHA-NIOSH Response to the Deepwater Horizon Oil Spill: Protecting the Health and Safety of Cleanup Workers. PLoS Currents Disasters. 2012 Jul 18 PMID:24678440

  19. New Horizons at Pluto: Asking the right questions

    NASA Astrophysics Data System (ADS)

    Young, Leslie; Stern, S. Alan; Olkin, Catherine B.; Spencer, John R.; Cheng, Andrew F.; Weaver, Harold A.; Ennico, Kimberly; Moore, Jeffrey M.; Grundy, William M.; Bagenal, Fran; Gladstone, Randy; Lunine, Jonathan I.; New Horizons Science Team

    2016-10-01

    In the 1980's and 1990's, breakthroughs about Pluto and the outer solar system laid the groundwork for the Outer Planets Science Working Group (1992), the Pluto Kuiper Express mission Science Definition Team (1996), and the Announcement of Opportunity for the Pluto Kuiper-Belt mission in 2001. These included specific science goals that molded the mission design, instrument selection, and observing sequence. These goals held up amazingly well over the decades. This historical review of New Horizons will explain how ground-based and theoretical work prepared us for a successful investigation of Pluto, and speculate on some of the new questions raised by the New Horizons flyby of the Pluto system.This work was supported by NASA's New Horizons project.

  20. Optimal control of circular cylinder wakes using long control horizons

    NASA Astrophysics Data System (ADS)

    Flinois, Thibault L. B.; Colonius, Tim

    2015-08-01

    The classical problem of suppressing vortex shedding in the wake of a circular cylinder by using body rotation is revisited in an adjoint-based optimal control framework. The cylinder's unsteady and fully unconstrained rotation rate is optimized at Reynolds numbers between 75 and 200 and over horizons that are longer than in previous studies, where they are typically of the order of a vortex shedding period or shorter. In the best configuration, the drag is reduced by 19%, the vortex shedding is effectively suppressed, and this low drag state is maintained with minimal cylinder rotation after transients. Unlike open-loop control, the optimal control is shown to maintain a specific phase relationship between the actuation and the shedding in order to stabilize the wake. A comparison is also given between the performance of optimizations for different Reynolds numbers, cost functions, and horizon lengths. It is shown that the long horizons used are necessary in order to stabilize the vortex shedding efficiently.

  1. Asymptotically Lifshitz spacetimes with universal horizons in (1 +2 ) dimensions

    NASA Astrophysics Data System (ADS)

    Basu, Sayandeb; Bhattacharyya, Jishnu; Mattingly, David; Roberson, Matthew

    2016-03-01

    Hořava gravity theory possesses global Lifshitz space as a solution and has been conjectured to provide a natural framework for Lifshitz holography. We derive the conditions on the two-derivative Hořava gravity Lagrangian that are necessary for static, asymptotically Lifshitz spacetimes with flat transverse dimensions to contain a universal horizon, which plays a similar thermodynamic role as the Killing horizon in general relativity. Specializing to z =2 in 1 +2 dimensions, we then numerically construct such regular solutions over the whole spacetime. We calculate the mass for these solutions and show that, unlike the asymptotically anti-de Sitter case, the first law applied to the universal horizon is straightforwardly compatible with a thermodynamic interpretation.

  2. Universality in chaos of particle motion near black hole horizon

    NASA Astrophysics Data System (ADS)

    Hashimoto, Koji; Tanahashi, Norihiro

    2017-01-01

    The motion of a particle near a horizon of a spherically symmetric static black hole is shown to possess a universal Lyapunov exponent of chaos bounded by its surface gravity. To probe the horizon, we introduce an electromagnetic or scalar force to the particle so that it does not fall into the horizon. There appears an unstable maximum of the total potential where the evaluated maximal Lyapunov exponent is found to be to the surface gravity of the black hole. This value is independent of the external forces, the particle mass and background geometry, and in this sense this Lyapunov exponent is universal. Unless there are other sources of chaos, the Lyapunov exponent is subject to an inequality λ ≤2 π TBH/ℏ, which is identical to the bound recently discovered by Maldacena, Shenker, and Stanford.

  3. Black hole thermodynamics from near-horizon conformal quantum mechanics

    SciTech Connect

    Camblong, Horacio E.; Ordonez, Carlos R.

    2005-05-15

    The thermodynamics of black holes is shown to be directly induced by their near-horizon conformal invariance. This behavior is exhibited using a scalar field as a probe of the black hole gravitational background, for a general class of metrics in D spacetime dimensions (with D{>=}4). The ensuing analysis is based on conformal quantum mechanics, within a hierarchical near-horizon expansion. In particular, the leading conformal behavior provides the correct quantum statistical properties for the Bekenstein-Hawking entropy, with the near-horizon physics governing the thermodynamics from the outset. Most importantly: (i) this treatment reveals the emergence of holographic properties; (ii) the conformal coupling parameter is shown to be related to the Hawking temperature; and (iii) Schwarzschild-like coordinates, despite their 'coordinate singularity', can be used self-consistently to describe the thermodynamics of black holes.

  4. Priority Questions and Horizon Scanning for Conservation: A Comparative Study

    PubMed Central

    Kark, Salit; Sutherland, William J.; Shanas, Uri; Klass, Keren; Achisar, Hila; Dayan, Tamar; Gavrieli, Yael; Justo-Hanani, Ronit; Mandelik, Yael; Orion, Nir; Pargament, David; Portman, Michelle; Reisman-Berman, Orna; Safriel, Uriel N.; Schaffer, Gad; Steiner, Noa; Tauber, Israel; Levin, Noam

    2016-01-01

    Several projects aimed at identifying priority issues for conservation with high relevance to policy have recently been completed in several countries. Two major types of projects have been undertaken, aimed at identifying (i) policy-relevant questions most imperative to conservation and (ii) horizon scanning topics, defined as emerging issues that are expected to have substantial implications for biodiversity conservation and policy in the future. Here, we provide the first overview of the outcomes of biodiversity and conservation-oriented projects recently completed around the world using this framework. We also include the results of the first questions and horizon scanning project completed for a Mediterranean country. Overall, the outcomes of the different projects undertaken (at the global scale, in the UK, US, Canada, Switzerland and in Israel) were strongly correlated in terms of the proportion of questions and/or horizon scanning topics selected when comparing different topic areas. However, some major differences were found across regions. There was large variation among regions in the percentage of proactive (i.e. action and response oriented) versus descriptive (non-response oriented) priority questions and in the emphasis given to socio-political issues. Substantial differences were also found when comparing outcomes of priority questions versus horizon scanning projects undertaken for the same region. For example, issues related to climate change, human demography and marine ecosystems received higher priority as horizon scanning topics, while ecosystem services were more emphasized as current priority questions. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. We propose that further emphasis on social-political issues should be explicitly integrated into future

  5. Priority Questions and Horizon Scanning for Conservation: A Comparative Study.

    PubMed

    Kark, Salit; Sutherland, William J; Shanas, Uri; Klass, Keren; Achisar, Hila; Dayan, Tamar; Gavrieli, Yael; Justo-Hanani, Ronit; Mandelik, Yael; Orion, Nir; Pargament, David; Portman, Michelle; Reisman-Berman, Orna; Safriel, Uriel N; Schaffer, Gad; Steiner, Noa; Tauber, Israel; Levin, Noam

    2016-01-01

    Several projects aimed at identifying priority issues for conservation with high relevance to policy have recently been completed in several countries. Two major types of projects have been undertaken, aimed at identifying (i) policy-relevant questions most imperative to conservation and (ii) horizon scanning topics, defined as emerging issues that are expected to have substantial implications for biodiversity conservation and policy in the future. Here, we provide the first overview of the outcomes of biodiversity and conservation-oriented projects recently completed around the world using this framework. We also include the results of the first questions and horizon scanning project completed for a Mediterranean country. Overall, the outcomes of the different projects undertaken (at the global scale, in the UK, US, Canada, Switzerland and in Israel) were strongly correlated in terms of the proportion of questions and/or horizon scanning topics selected when comparing different topic areas. However, some major differences were found across regions. There was large variation among regions in the percentage of proactive (i.e. action and response oriented) versus descriptive (non-response oriented) priority questions and in the emphasis given to socio-political issues. Substantial differences were also found when comparing outcomes of priority questions versus horizon scanning projects undertaken for the same region. For example, issues related to climate change, human demography and marine ecosystems received higher priority as horizon scanning topics, while ecosystem services were more emphasized as current priority questions. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. We propose that further emphasis on social-political issues should be explicitly integrated into future

  6. New Horizons: Gas and Plasma in the Pluto System

    NASA Astrophysics Data System (ADS)

    Young, Leslie; Gladstone, Randy; Summers, Michael; Bagenal, Fran; Stern, S. Alan; Weaver, Harold A.; Olkin, Catherine B.; Ennico, Kimberly; Moore, Jeffrey M.; Grundy, William M.; New Horizons Atmospheres Science Theme Team, New Horizons Particles and Plasma Science Theme Team

    2016-10-01

    NASA's New Horizons mission gave us information about gas and plasma in the Pluto system from Pluto's surface up to a distance of ~200,000 km beyond Pluto. This review will give an overview of our current theories and observations of the near-surface atmospheric structure; the properties, production and settling of Pluto's ubiquitous haze; the minor atmospheric species and atmospheric chemistry; the energetics and high-altitude thermal structure; the escape rate and the pickup of methane ions; the effect of methane impacting Charon; and Pluto's heavy-ion tail. Details are given in other presentations at this conference.This work was supported by NASA's New Horizons project.

  7. A Horizon Scan of Global Conservation Issues for 2016.

    PubMed

    Sutherland, William J; Broad, Steven; Caine, Jacqueline; Clout, Mick; Dicks, Lynn V; Doran, Helen; Entwistle, Abigail C; Fleishman, Erica; Gibbons, David W; Keim, Brandon; LeAnstey, Becky; Lickorish, Fiona A; Markillie, Paul; Monk, Kathryn A; Mortimer, Diana; Ockendon, Nancy; Pearce-Higgins, James W; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Spalding, Mark D; Tonneijck, Femke H; Wintle, Bonnie C; Wright, Katherine E

    2016-01-01

    This paper presents the results of our seventh annual horizon scan, in which we aimed to identify issues that could have substantial effects on global biological diversity in the future, but are not currently widely well known or understood within the conservation community. Fifteen issues were identified by a team that included researchers, practitioners, professional horizon scanners, and journalists. The topics include use of managed bees as transporters of biological control agents, artificial superintelligence, electric pulse trawling, testosterone in the aquatic environment, building artificial oceanic islands, and the incorporation of ecological civilization principles into government policies in China.

  8. Spores, pollen, and microplankton from the horizon Beta outcrop.

    PubMed

    Habib, D

    1968-12-27

    Palynology was used for dating a pre-Pleistocene deep-sea organic lutite layer situated stratigraphically near seismic horizon beta, below horizon A. The spores and pollen are closely identified, quantitatively, with nonmarine and marine Middle Cretaceous assemblages (Albian-Cenomanian) on the continents, an age designation that is confirmed by the occurrence of dinoflagellate cysts, acritarchs, foraminifers, and coccoliths in the investigated cores. The abundance of these well-preserved, land-derived assemblages in an area far removed from a source suggests some tectonic displacement since their deposition.

  9. Foliation dependence of black hole apparent horizons in spherical symmetry

    NASA Astrophysics Data System (ADS)

    Faraoni, Valerio; Ellis, George F. R.; Firouzjaee, Javad T.; Helou, Alexis; Musco, Ilia

    2017-01-01

    Numerical studies of gravitational collapse to black holes make use of apparent horizons, which are intrinsically foliation dependent. We expose the problem and discuss possible solutions using the Hawking-Hayward quasilocal mass. In spherical symmetry, we present a physically sensible approach to the problem by restricting to spherically symmetric spacetime slicings. In spherical symmetry, the apparent horizons enjoy a restricted gauge independence in any spherically symmetric foliation, but physical quantities associated with them, such as surface gravity and temperature, are fully gauge dependent. The widely used comoving and Kodama foliations, which are of particular interest, are discussed in detail as examples.

  10. A horizon scan of global conservation issues for 2014.

    PubMed

    Sutherland, William J; Aveling, Rosalind; Brooks, Thomas M; Clout, Mick; Dicks, Lynn V; Fellman, Liz; Fleishman, Erica; Gibbons, David W; Keim, Brandon; Lickorish, Fiona; Monk, Kathryn A; Mortimer, Diana; Peck, Lloyd S; Pretty, Jules; Rockström, Johan; Rodríguez, Jon Paul; Smith, Rebecca K; Spalding, Mark D; Tonneijck, Femke H; Watkinson, Andrew R

    2014-01-01

    This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease.

  11. A horizon scan of global conservation issues for 2014

    PubMed Central

    Sutherland, William J.; Aveling, Rosalind; Brooks, Thomas M.; Clout, Mick; Dicks, Lynn V.; Fellman, Liz; Fleishman, Erica; Gibbons, David W.; Keim, Brandon; Lickorish, Fiona; Monk, Kathryn A.; Mortimer, Diana; Peck, Lloyd S.; Pretty, Jules; Rockström, Johan; Rodríguez, Jon Paul; Smith, Rebecca K.; Spalding, Mark D.; Tonneijck, Femke H.; Watkinson, Andrew R.

    2014-01-01

    This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease. PMID:24332318

  12. Moving Toward Polarimetry with the Event Horizon Telescope

    NASA Astrophysics Data System (ADS)

    Kosowsky, Michael; Fish, V. L.; Doeleman, S.; Johnson, M.; Lu, R.; Marrone, D. P.; Moran, J. M.; Plambeck, R. L.; Wardle, J. F.; EHT Collaboration

    2014-01-01

    The Event Horizon Telescope (EHT) project aims to develop millimeter and submillimeter VLBI to achieve angular resolution of tens of microarcseconds, comparable to the event horizons of nearby supermassive black holes. A major challenge for polarimetry at these scales is instrumental cross-talk, which introduces spurious linear polarization that can easily overwhelm the intrinsic signal. We demonstrate a new method for correcting the instrumental response, based on Markov Chain Monte Carlo simulations and other non-linear fitting methods. We will present preliminary polarimetric results on several EHT targets. Future EHT observations will provide a new window into the rich magnetic structures of their innermost cores.

  13. Earth, Meet Pluto: The New Horizons Education and Communications Partnership

    NASA Astrophysics Data System (ADS)

    Buckley, M.

    2015-12-01

    The unique partnership between the NASA New Horizons education/communications and public affairs programs tapped into the excitement of visiting an unexplored planet in a new region of the solar system - resulting in unprecedented public participation in and coverage of a planetary mission. With a range of hands-on learning experiences, Web materials and online , the program provided opportunities for students, educators, museums, science centers, the media, Web surfers and other members of the public to ride along on the first mission to Pluto and the Kuiper Belt. The programs leveraged resources, materials and expertise to address a wide range of traditional and nontraditional audiences while providing consistent messages and information on this historic NASA endeavor. The E/C program included a variety of formal lesson plans and learning materials — based on New Horizons science and engineering goals, and aligned with National Research Council's National Science Education Standards — that continue to help students in grades K-12 learn more about science, technology, engineering and mathematics. College students designed and built an actual flight instrument on New Horizons and held internships with the spacecraft integration and test team. New Horizons E/C programs went well beyond the classroom, from a chance for people to send their names to Pluto on board the New Horizons spacecraft before launch, to opportunities for the public to access milestone events and the first-ever close-up views of Pluto in places such as museums, science centers and libraries, TV and the Web — as well as thousands who attended interactive "Plutopalooza" road shows across the country. Teamed with E/C was the public affairs strategy to communicate New Horizons news and messages to media, mission stakeholders, the scientific community and the public. These messages include various aspects of New Horizons, including the progress of the mission and key milestones and achievements

  14. Robust Consumption-Investment Problem on Infinite Horizon

    SciTech Connect

    Zawisza, Dariusz

    2015-12-15

    In our paper we consider an infinite horizon consumption-investment problem under a model misspecification in a general stochastic factor model. We formulate the problem as a stochastic game and finally characterize the saddle point and the value function of that game using an ODE of semilinear type, for which we provide a proof of an existence and uniqueness theorem for its solution. Such equation is interested on its own right, since it generalizes many other equations arising in various infinite horizon optimization problems.

  15. Generalized Robertson-Walker Space-Time Admitting Evolving Null Horizons Related to a Black Hole Event Horizon

    PubMed Central

    2016-01-01

    A new technique is used to study a family of time-dependent null horizons, called “Evolving Null Horizons” (ENHs), of generalized Robertson-Walker (GRW) space-time (M¯,g¯) such that the metric g¯ satisfies a kinematic condition. This work is different from our early papers on the same issue where we used (1 + n)-splitting space-time but only some special subcases of GRW space-time have this formalism. Also, in contrast to previous work, we have proved that each member of ENHs is totally umbilical in (M¯,g¯). Finally, we show that there exists an ENH which is always a null horizon evolving into a black hole event horizon and suggest some open problems. PMID:27722202

  16. Development of a Fragment-Based in Silico Profiler for Michael Addition Thiol Reactivity.

    PubMed

    Ebbrell, David J; Madden, Judith C; Cronin, Mark T D; Schultz, Terry W; Enoch, Steven J

    2016-06-20

    The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adverse effect. An important example of a well-defined MIE is the formation of a covalent bond between a biological nucleophile and an electrophilic compound. This particular MIE has been associated with various toxicological end points such as acute aquatic toxicity, skin sensitization, and respiratory sensitization. This study has investigated the calculated parameters that are required to predict the rate of chemical bond formation (reactivity) of a dataset of Michael acceptors. Reactivity of these compounds toward glutathione was predicted using a combination of a calculated activation energy value (Eact, calculated using density functional theory (DFT) calculation at the B3YLP/6-31G+(d) level of theory, and solvent-accessible surface area values (SAS) at the α carbon. To further develop the method, a fragment-based algorithm was developed enabling the reactivity to be predicted for Michael acceptors without the need to perform the time-consuming DFT calculations. Results showed the developed fragment method was successful in predicting the reactivity of the Michael acceptors excluding two sets of chemicals: volatile esters with an extended substituent at the β-carbon and chemicals containing a conjugated benzene ring as part of the polarizing group. Additionally the study also demonstrated the ease with which the approach can be extended to other chemical classes by the calculation of additional fragments and their associated Eact and SAS values. The resulting method is likely to be of use in regulatory toxicology tools where an understanding of covalent bond formation as a potential MIE is important within the AOP paradigm.

  17. On the relative preference of enamine/iminium pathways in an organocatalytic Michael addition reaction.

    PubMed

    Patil, Mahendra P; Sunoj, Raghavan B

    2009-05-04

    The mechanism of the organocatalyzed Michael addition between propanal and methyl vinyl ketone is investigated using the density functional and ab intio methods. Different modes of substrate activation offered by a secondary amine (pyrrolidine) organocatalyst are reported. The electrophilic activation of enone (P-I) through the formation of an iminium ion, and nucleophilic activation of propanal (P-II) in the form of enamine have been examined by identifying the corresponding transition states. The kinetic preference for the formation of key intermediates is established in an effort to identify the competing pathways associated with the title reaction. A comparison of barriers associated with different pathways as well as intermediate formation allows us to provide a suitable mechanistic rationale for Michael addition reactions catalyzed by a secondary amine. The overall barriers for the C-C bond formation pathways involving enol or iminium intermediates are identified as higher than the enamine pathway. Additionally, the generation of iminium is found to be less favored as compared to enamine formation. The effect of co-catalyst/protic solvent on the energetics of the overall reaction is also studied using the cluster continuum approach. Significant reduction in the activation energies for each step of the reaction is predicted for the solvent-assisted models. The co-catalyst assisted addition of propanal-enamine to methyl vinyl ketone is identified as the most preferred pathway (P-IV) for the Michael addition reaction. The results are in concurrence with the available experimental reports on the rate acceleration by the use of a co-catalyst in this reaction.

  18. [The problem of evil in families--the filmmaker Michael Haneke].

    PubMed

    Skårderud, Finn

    2010-09-23

    With the beautiful and dark film "The white ribbon", from 2009, the Austrian film director Michael Haneke consolidated his status as an international success. A central theme in his films is evilness and its roots. But just as important is his ambition to develop films where evil is not only portrayed, but where spectators are challenged to relate to their own ethical standards and their role as spectators. Haneke is a highly original filmmaker with his consistent search for a film aesthetic that stimulates ethical self-reflection and mentalizing. He partly succeeds in this quest.

  19. Enantio- and Diastereoselective Synthesis of exo-Peroxyacetals: An Organocatalyzed Peroxyhemiacetalization/oxa-Michael Addition Cascade.

    PubMed

    Maity, Sanjay; Parhi, Biswajit; Ghorai, Prasanta

    2016-06-27

    An unprecedented enantioselective peroxyhemiacetalization/oxa-Michael addition cascade of ortho-formyl homochalcones has been developed using cinchona-alkaloid-based chiral bifunctional organocatalysts to provide cis-configured exo-peroxyacetals, a new class of organic peroxide, in good yields with excellent enantio- and diastereoselectivities. The resulting cis-configured exo-peroxyacetals were converted into the corresponding trans-configured peroxyacetals without affecting the enantioselectivity. Furthermore, the displacement of the peroxide moiety of exo-peroxyacetals with various nucleophiles has been demonstrated to afford 1,3-disubstituted isochromans with high diastereoselectivities and excellent enantioselectivities.

  20. Conversion of Substrate Analogs Suggests a Michael Cyclization in Iridoid Biosynthesis

    PubMed Central

    Lindner, Stephanie; Geu-Flores, Fernando; Bräse, Stefan; Sherden, Nathaniel H.; O’Connor, Sarah E.

    2014-01-01

    Summary The core structure of the iridoid monoterpenes is formed by a unique cyclization reaction. The enzyme that catalyzes this reaction, iridoid synthase, is mechanistically distinct from other terpene cyclases. Here we describe the synthesis of two substrate analogs to probe the mechanism of iridoid synthase. Enzymatic assay of these substrate analogs along with clues from the product profile of the native substrate strongly suggest that iridoid synthase utilizes a Michael reaction to achieve cyclization. This improved mechanistic understanding will facilitate the exploitation of the potential of iridoid synthase to synthesize new cyclic compounds from nonnatural substrates. PMID:25444551

  1. An interview with Michael M. Gottesman, M.D. Interview by Vicki Glaser.

    PubMed

    Gottesman, Michael M

    2009-06-01

    Dr. Michael Gottesman obtained his M.D. from Harvard University Medical School, completed his internship and residency in medicine at the Peter Bent Brigham Hospital in Boston, and received his postdoctoral research training in molecular genetics with Martin Gellert at the National Institutes of Health (NIH). After a year as an assistant professor in the Department of Anatomy at Harvard, he moved to the NIH in 1976. He currently serves as the NIH Deputy Director for Intramural Research as well as Chief of the Laboratory of Cell Biology.

  2. The English Patient: Michael Ondaatje's characterization of the nurse-patient relationship.

    PubMed

    Metcalf, James

    2009-01-01

    I recently used The English Patient (both the novel and the movie) with an undergraduate health science class to explore the unique character of the patient-provider relationship. Through the interactions of a young Canadian nurse and her "English" patient, author Michael Ondaatje presents an interesting view of the nurse-patient relationship. In this essay, I use quotations from the novel to demonstrate that Ondaatje sees the nurse-patient relationship as somber, sensual, and compassionate. The theme is particularly relevant to nursing students and those who teach them.

  3. A summary of seven- and eight-membered ring sultam syntheses via three Michael addition reactions.

    PubMed

    Niu, Ben; Xie, Ping; Wang, Min; Wang, Yanjie; Zhao, Wannian; Pittman, Charles U; Zhou, Aihua

    2015-08-01

    A series of seven- and eight-membered ring -N,O-, -N,N-, and -N,S-sultams were effectively synthesized via tandem reactions involving oxa-, aza-, and thia-Michael addition to vinyl sulfonamides. These reactions are summarized here since they enrich current synthetic methodologies for sultams and provide a good example of sultam diversity-oriented synthesis. All reactions proceeded under relatively mild and environmentally friendly conditions, and all these reactions are quite suitable for the rapid preparation of sultam compound libraries, which are valuable for biological activity explorations.

  4. Bioactive Diterpenoid Containing a Reversible “Spring-Loaded” (E,Z)-dieneone Michael Acceptor

    PubMed Central

    Gupta, Prasoon; Sharma, Upasana; Schulz, Thomas C.; Sherrer, Eric S.; McLean, Amanda B.; Robins, Allan J.; West, Lyndon M.

    2012-01-01

    Three new briarane diterpenoids, briareolate esters L – N (1 – 3) have been isolated from a gorgonian Briareum asbestinum. Briareolate esters L (1) and M (2) are the first natural products possessing a 10-membered macrocyclic ring with a (E,Z)-dieneone and exhibit growth inhibition activity against both human embryonic stem cells (BG02) and a pancreatic cancer cell line (BxPC-3). Briareolate ester L (1), was found to contain a “spring-loaded” (E,Z)-dieneone Michael acceptor group that can form a reversible covalent bond to model sulfur-based nucleophiles. PMID:21749084

  5. Michael E. Barnes: Award for Distinguished Professional Contributions to Institutional Practice.

    PubMed

    2012-11-01

    Presents a short biography on the winner of the American Psychological Association's Award for Distinguished Professional Contributions to Institutional Practice. The 2012 winner is Michael E. Barnes for his pioneering leadership, dedication, and distinguished contributions to juvenile justice. As chief psychologist of the Superior Court of the District of Columbia's Child Guidance Clinic, Barnes and his staff have provided exceptional psychological service to thousands of adjudicated youths, developed an APA-accredited internship program, and supervised the development of a juvenile mental health court that diverts mentally ill court-involved youth from delinquency proceedings and into treatment.

  6. Michael Servetus (1511-1553): physician and heretic who described the pulmonary circulation.

    PubMed

    Bosmia, Anand; Watanabe, Koichi; Shoja, Mohammadali M; Loukas, Marios; Tubbs, R Shane

    2013-07-31

    The purpose of this paper is to provide an overview of the life of the physician and theologian Michael Servetus and to discuss his analysis of the pulmonary circulation. Writers have praised Servetus for his commitment to educating his colleagues about what he heralded as the truth, and criticized him for his perceived arrogance. Servetus made contributions to the fields of geography, astrology, theology, and medicine. This paper refers to the translation of a portion of Servetus' book Christianismi Restitutio by Charles D. O'Malley.

  7. The acquisition and maintenance of behavioral skills: A response to Michael

    PubMed Central

    Knapp, Craig W.

    1982-01-01

    A response to Michael's (1980) presidential address to the Association for Behavior Analysis is presented. The position is taken that in many instances we have failed to adopt a behavioral approach to dealing with problems within our field concomitant with the shift from an emphasis on behaviorism and a science of behavior to technology. It is argued that we need to be sensitive to the data and consider the contingencies that are operating within the culture. A general strategy and some tactics are presented to acquire and maintain behavioral skills. PMID:22478559

  8. Organocatalytic Michael and Friedel-Crafts reactions in enantioselective synthesis of biologically active compounds

    NASA Astrophysics Data System (ADS)

    Maltsev, O. V.; Beletskaya, Irina P.; Zlotin, Sergei G.

    2011-11-01

    Recent applications of organocatalytic Michael and Friedel-Crafts reactions in enantioselective synthesis of biologically active compounds: natural products, pharmaceutical agents and plant protection agents are reviewed. The key mechanisms of stereoinduction, types of organocatalysts and reagents used in these reactions are considered. The material is classified according to the type of newly formed bonds incorporating the asymmetric carbon atom, and the information for the most numerous C-C coupling reactions is systematized according to the natures of the electrophile and the nucleophile. The bibliography includes 433 references. Dedicated to Academician O M Nefedov on the occasion of his 80th birthday.

  9. Michael E. Lamb: Award for Distinguished Senior Career Contributions to Psychology in the Public Interest.

    PubMed

    2015-11-01

    The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2015 co-recipient of the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest is Michael E. Lamb. Lamb was selected because his "work profoundly shaped the fields of developmental psychology, social welfare, child and family policy, and law." Lamb's award citation, biography, and a selected bibliography are presented here.

  10. Supported bifunctional thioureas as recoverable and reusable catalysts for enantioselective nitro-Michael reactions.

    PubMed

    Andrés, José M; Ceballos, Miriam; Maestro, Alicia; Sanz, Isabel; Pedrosa, Rafael

    2016-01-01

    The catalytic activity of different supported bifunctional thioureas on sulfonylpolystyrene resins has been studied in the nitro-Michael addition of different nucleophiles to trans-β-nitrostyrene derivatives. The activity of the catalysts depends on the length of the tether linking the chiral thiourea to the polymer. The best results were obtained with the thiourea derived from (L)-valine and 1,6-hexanediamine. The catalysts can be used in only 2 mol % loading, and reused for at least four cycles in neat conditions. The ball milling promoted additions also worked very well.

  11. Supported bifunctional thioureas as recoverable and reusable catalysts for enantioselective nitro-Michael reactions

    PubMed Central

    Ceballos, Miriam; Maestro, Alicia; Sanz, Isabel

    2016-01-01

    Summary The catalytic activity of different supported bifunctional thioureas on sulfonylpolystyrene resins has been studied in the nitro-Michael addition of different nucleophiles to trans-β-nitrostyrene derivatives. The activity of the catalysts depends on the length of the tether linking the chiral thiourea to the polymer. The best results were obtained with the thiourea derived from (L)-valine and 1,6-hexanediamine. The catalysts can be used in only 2 mol % loading, and reused for at least four cycles in neat conditions. The ball milling promoted additions also worked very well. PMID:27340453

  12. Through the looking glass: why the `cosmic horizon' is not a horizon

    NASA Astrophysics Data System (ADS)

    van Oirschot, Pim; Kwan, Juliana; Lewis, Geraint F.

    2010-06-01

    The present standard model of cosmology, Λ cold dark matter (ΛCDM), contains some intriguing coincidences. Not only are the dominant contributions to the energy density approximately of the same order at the present epoch, but we also note that contrary to the emergence of cosmic acceleration as a recent phenomenon, the time-averaged value of the deceleration parameter over the age of the Universe is nearly zero. Curious features like these in ΛCDM give rise to a number of alternate cosmologies being proposed to remove them, including models with an equation of state w = -1/3. In this paper, we examine the validity of some of these alternate models and we also address some persistent misconceptions about the Hubble sphere and the event horizon that lead to erroneous conclusions about cosmology. Research undertaken as part of the Commonwealth Cosmology Initiative (CCI: http://www.thecci.org), an international collaboration supported by the Australian Research Council. E-mail: pimvanoirschot@gmail.com

  13. Kinetics and Thermodynamics of Reversible Thiol Additions to Mono- and Diactivated Michael Acceptors: Implications for the Design of Drugs That Bind Covalently to Cysteines.

    PubMed

    Krenske, Elizabeth H; Petter, Russell C; Houk, K N

    2016-12-02

    Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of several covalent drugs (e.g., afatinib, osimertinib, ibrutinib, neratinib, and CC-292). Reversible Michael acceptors have been reported in which an additional electron-withdrawing group was added at the α-carbon of a Michael acceptor. We have performed density functional theory calculations to determine why thiol additions to these Michael acceptors are reversible. The α-EWG group stabilizes the anionic transition state and intermediate of the Michael addition, but less intuitively, it destabilizes the neutral adduct. This makes the reverse reaction (elimination) both faster and more thermodynamically favorable. For thiol addition to be reversible, the Michael acceptor must also contain a suitable substituent on the β-carbon, such as an aryl or branched alkyl group. Computations explain how these structural elements contribute to reversibility and the ability to tune the binding affinities and the residence times of covalent inhibitors.

  14. What happens to Petrov classification, on horizons of axisymmetric dirty black holes

    SciTech Connect

    Tanatarov, I. V.; Zaslavskii, O. B.

    2014-02-15

    We consider axisymmetric stationary dirty black holes with regular non-extremal or extremal horizons, and compute their on-horizon Petrov types. The Petrov type (PT) in the frame of the observer crossing the horizon can be different from that formally obtained in the usual (but singular in the horizon limit) frame of an observer on a circular orbit. We call this entity the boosted Petrov type (BPT), as the corresponding frame is obtained by a singular boost from the regular one. The PT off-horizon can be more general than PT on-horizon and that can be more general than the BPT on horizon. This is valid for all regular metrics, irrespective of the extremality of the horizon. We analyze and classify the possible relations between the three characteristics and discuss the nature and features of the underlying singular boost. The three Petrov types can be the same only for space-times of PT D and O off-horizon. The mutual alignment of principal null directions and the generator in the vicinity of the horizon is studied in detail. As an example, we also analyze a special class of metrics with utra-extremal horizons (for which the regularity conditions look different from the general case) and compare their off-horizon and on-horizon algebraic structure in both frames.

  15. Ecological Impacts during the Deepwater Horizon Oil Spill

    EPA Science Inventory

    The Deepwater Horizon (DWH) oil spill was the largest spill and response effort in United States history. Nearly 800 million L of oil was spilled in the Gulf of Mexico, and nearly 7 million L of chemical dispersants were applied in at the ocean surface and subsea1. The DWH spill ...

  16. New Horizons: An Empowerment Program for Egyptian Adolescent Girls.

    ERIC Educational Resources Information Center

    Swanson, Julie Hanson

    New Horizons is a nonschool program that demystifies and communicates essential information on basic life skills and reproductive health to Egyptian girls and young women aged 9-20. The program consists of 100 hour-long sessions, each including an introduction to a specific topic, review of group knowledge level, discussion around key points…

  17. Apparent horizons in D-dimensional Robinson-Trautman spacetime

    SciTech Connect

    Svitek, Otakar

    2009-05-01

    We derive the higher dimensional generalization of Penrose-Tod equation describing apparent horizons in Robinson-Trautman spacetimes. New results concerning the existence and uniqueness of its solutions in four dimensions are proven. Namely, previous results of Tod [1] are generalized to nonvanishing cosmological constant.

  18. Beyond Symbolic Processing: Expanding Horizons for Educational Psychology.

    ERIC Educational Resources Information Center

    Derry, Sharon J.

    1992-01-01

    The horizons are expanding for educational psychology as important questions are being raised about the extent and nature of the relationship between formal schooling and life experiences. A broadening of perspectives is required to incorporate cultural contexts and forces in which schooling takes part. (SLD)

  19. Broadening the Horizons: Organizational Communication in the Real World.

    ERIC Educational Resources Information Center

    Swanson, Georgia

    Working in the microcosm of an individual class, organizational communication instructors can broaden the student's horizon by starting with what are local types of diversity and then expanding the classroom understanding to include the larger world where that student is going to live and work. Speech communication teachers/scholars have seen…

  20. Ecological Impacts During the Deepwater Horizon Oil Spill Response

    EPA Science Inventory

    The Deepwater Horizon (DWH) oil spill was the largest environmental disaster and response effort in U.S. history, with nearly 800 million liters of crude oil spilled. Vast areas of the Gulf of Mexico were contaminated with oil, including deep-ocean communities and over 1,600 kilo...