Test of a prototype neutron spectrometer based on diamond detectors in a fast reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Osipenko, M.; Ripani, M.; Ricco, G.

2015-07-01

A prototype of neutron spectrometer based on diamond detectors has been developed. This prototype consists of a {sup 6}Li neutron converter sandwiched between two CVD diamond crystals. The radiation hardness of the diamond crystals makes it suitable for applications in low power research reactors, while a low sensitivity to gamma rays and low leakage current of the detector permit to reach good energy resolution. A fast coincidence between two crystals is used to reject background. The detector was read out using two different electronic chains connected to it by a few meters of cable. The first chain was based onmore » conventional charge-sensitive amplifiers, the other used a custom fast charge amplifier developed for this purpose. The prototype has been tested at various neutron sources and showed its practicability. In particular, the detector was calibrated in a TRIGA thermal reactor (LENA laboratory, University of Pavia) with neutron fluxes of 10{sup 8} n/cm{sup 2}s and at the 3 MeV D-D monochromatic neutron source named FNG (ENEA, Rome) with neutron fluxes of 10{sup 6} n/cm{sup 2}s. The neutron spectrum measurement was performed at the TAPIRO fast research reactor (ENEA, Casaccia) with fluxes of 10{sup 9} n/cm{sup 2}s. The obtained spectra were compared to Monte Carlo simulations, modeling detector response with MCNP and Geant4. (authors)« less

The Full-Scale Prototype for the Fluorescence Detector Array of Single-Pixel Telescopes

NASA Astrophysics Data System (ADS)

Fujii, T.; Malacari, M.; Bellido, J. A.; Farmer, J.; Galimova, A.; Horvath, P.; Hrabovsky, M.; Mandat, D.; Matalon, A.; Matthews, J. N.; Merolle, M.; Ni, X.; Nozka, L.; Palatka, M.; Pech, M.; Privitera, P.; Schovanek, P.; Thomas, S. B.; Travnicek, P.

The Fluorescence detector Array of Single-pixel Telescopes (FAST) is a design concept for the next generation of ultrahigh-energy cosmic ray (UHECR) observatories, addressing the requirements for a large-area, low-cost detector suitable for measuring the properties of the highest energy cosmic rays. In the FAST design, a large field of view is covered by a few pixels at the focal plane of a mirror or Fresnel lens. Motivated by the successful detection of UHECRs using a prototype comprised of a single 200 mm photomultiplier-tube and a 1 m2 Fresnel lens system, we have developed a new "full-scale" prototype consisting of four 200 mm photomultiplier-tubes at the focus of a segmented mirror of 1.6 m in diameter. We report on the status of the full-scale prototype, including test measurements made during first light operation at the Telescope Array site in central Utah, U.S.A.

Fast-responder: Rapid mobile-phone access to recent remote sensing imagery for first responders

NASA Astrophysics Data System (ADS)

Talbot, L. M.; Talbot, B. G.

We introduce Fast-Responder, a novel prototype data-dissemination application and architecture concept to rapidly deliver remote sensing imagery to smartphones to enable situational awareness. The architecture implements a Fast-Earth image caching system on the phone and interacts with a Fast-Earth server. Prototype evaluation successfully demonstrated that National Guard users could select a location, download multiple remote sensing images, and flicker between images, all in less than a minute on a 3G mobile commercial link. The Fast-Responder architecture is a significant advance that is designed to meet the needs of mobile users, such as National Guard response units, to rapidly access information during a crisis, such as a natural or man-made disaster. This paper focuses on the architecture design and advanced user interface concepts for small-screens for highly active mobile users. Novel Fast-Responder concepts can also enable rapid dissemination and evaluation of imagery on the desktop, opening new technology horizons for both desktop and mobile users.

Prototyping Control and Data Acquisition for the ITER Neutral Beam Test Facility

NASA Astrophysics Data System (ADS)

Luchetta, Adriano; Manduchi, Gabriele; Taliercio, Cesare; Soppelsa, Anton; Paolucci, Francesco; Sartori, Filippo; Barbato, Paolo; Breda, Mauro; Capobianco, Roberto; Molon, Federico; Moressa, Modesto; Polato, Sandro; Simionato, Paola; Zampiva, Enrico

2013-10-01

The ITER Neutral Beam Test Facility will be the project's R&D facility for heating neutral beam injectors (HNB) for fusion research operating with H/D negative ions. Its mission is to develop technology to build the HNB prototype injector meeting the stringent HNB requirements (16.5 MW injection power, -1 MeV acceleration energy, 40 A ion current and one hour continuous operation). Two test-beds will be built in sequence in the facility: first SPIDER, the ion source test-bed, to optimize the negative ion source performance, second MITICA, the actual prototype injector, to optimize ion beam acceleration and neutralization. The SPIDER control and data acquisition system is under design. To validate the main architectural choices, a system prototype has been assembled and performance tests have been executed to assess the prototype's capability to meet the control and data acquisition system requirements. The prototype is based on open-source software frameworks running under Linux. EPICS is the slow control engine, MDSplus is the data handler and MARTe is the fast control manager. The prototype addresses low and high-frequency data acquisition, 10 kS/s and 10 MS/s respectively, camera image acquisition, data archiving, data streaming, data retrieval and visualization, real time fast control with 100 μs control cycle and supervisory control.

Fast-Track Building.

ERIC Educational Resources Information Center

Dolan, Thomas G.

2002-01-01

Describes Clark County, Nevada's use of prototype school designs to respond to its rapidly growing school population. The purpose of the prototypes is to simplify designs so that schools can be built quickly and minimize the time and expense that comes with variations. (EV)

Contextual E-Learning Evaluation: A Preliminary Framework

ERIC Educational Resources Information Center

Voigt, Christian; Swatman, Paula M. C.

2004-01-01

The evaluation of solutions is a major unresolved issue for all those involved in e-learning. In this paper we illustrate the importance of context by means of a qualitative comparison of two e-learning prototype implementations--an action research case undertaken in conjunction with a major German insurance company; and a more experimental…

Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium.

PubMed

Summerfield, Nuala; Peters, Mary E; Hercock, Carol A; Mobasheri, Ali; Young, Iain S

2010-04-01

Dilated cardiomyopathy (DCM) is one of the most common acquired canine heart diseases. It is particularly common in large and giant breed dogs. Although a great deal is known about the clinical progression and manifestations of the disease, the underlying cellular and molecular mechanisms remain poorly understood. One widely held belief is that calcium-handling abnormalities are critically involved in the disease process. This study investigates the changes in expression of the sarco(endo)plasmic reticulum calcium ATPase (SERCA) isoforms in DCM myocardium from German shepherd dogs. Affected tissue samples were obtained from German shepherd dogs with DCM, euthanized for intractable congestive heart failure while normal myocardial tissue samples were obtained from German shepherd dogs, euthanized for non-cardiovascular reasons. Tissue microarrays containing normal and DCM myocardium samples were prepared, immunostained with SERCA1 and SERCA2 antibodies and analyzed. We were able to demonstrate, for the first time, that while there is little change in the expression of the cardiac isoform (SERCA2), there is clear expression of the fast-twitch skeletal muscle isoform SERCA1 in the myocardium of dogs diagnosed with DCM. We propose that SERCA1 expression is evidence of a natural adaptive response to the impaired Ca2+ handling thought to occur in German shepherd dogs with DCM and heart failure. Copyright 2010 Elsevier B.V. All rights reserved.

Evaluation of a miniature microscope objective designed for fluorescence array microscopy detection of Mycobacterium tuberculosis.

PubMed

McCall, Brian; Olsen, Randall J; Nelles, Nicole J; Williams, Dawn L; Jackson, Kevin; Richards-Kortum, Rebecca; Graviss, Edward A; Tkaczyk, Tomasz S

2014-03-01

A prototype miniature objective that was designed for a point-of-care diagnostic array microscope for detection of Mycobacterium tuberculosis and previously fabricated and presented in a proof of concept is evaluated for its effectiveness in detecting acid-fast bacteria. To evaluate the ability of the microscope to resolve submicron features and details in the image of acid-fast microorganisms stained with a fluorescent dye, and to evaluate the accuracy of clinical diagnoses made with digital images acquired with the objective. The lens prescription data for the microscope design are presented. A test platform is built by combining parts of a standard microscope, a prototype objective, and a digital single-lens reflex camera. Counts of acid-fast bacteria made with the prototype objective are compared to counts obtained with a standard microscope over matched fields of view. Two sets of 20 smears, positive and negative, are diagnosed by 2 pathologists as sputum smear positive or sputum smear negative, using both a standard clinical microscope and the prototype objective under evaluation. The results are compared to a reference diagnosis of the same sample. More bacteria are counted in matched fields of view in digital images taken with the prototype objective than with the standard clinical microscope. All diagnostic results are found to be highly concordant. An array microscope built with this miniature lens design will be able to detect M tuberculosis with high sensitivity and specificity.

Distributed Adaptive Binary Quantization for Fast Nearest Neighbor Search.

PubMed

Xianglong Liu; Zhujin Li; Cheng Deng; Dacheng Tao

2017-11-01

Hashing has been proved an attractive technique for fast nearest neighbor search over big data. Compared with the projection based hashing methods, prototype-based ones own stronger power to generate discriminative binary codes for the data with complex intrinsic structure. However, existing prototype-based methods, such as spherical hashing and K-means hashing, still suffer from the ineffective coding that utilizes the complete binary codes in a hypercube. To address this problem, we propose an adaptive binary quantization (ABQ) method that learns a discriminative hash function with prototypes associated with small unique binary codes. Our alternating optimization adaptively discovers the prototype set and the code set of a varying size in an efficient way, which together robustly approximate the data relations. Our method can be naturally generalized to the product space for long hash codes, and enjoys the fast training linear to the number of the training data. We further devise a distributed framework for the large-scale learning, which can significantly speed up the training of ABQ in the distributed environment that has been widely deployed in many areas nowadays. The extensive experiments on four large-scale (up to 80 million) data sets demonstrate that our method significantly outperforms state-of-the-art hashing methods, with up to 58.84% performance gains relatively.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furuta, H.; Imura, A.; Furuta, Y.

Recently, technique of Gadolinium loaded liquid scintillator (Gd-LS) for reactor neutrino oscillation experiments has attracted attention as a monitor of reactor operation and 'nuclear Gain (GA)' for IAEA safeguards. For the practical use, R and D of the 1 ton class compact detector, which is measurable above ground, is necessary. Especially, it is important to reduce much amount of fast neutron background induced by cosmic muons with data analysis for the measurement above ground. We developed a prototype of the Gd-LS detector with 200 L of the target volume, which has Pulse Shape Discrimination (PSD) ability for the fast neutronmore » reduction with data analysis. Usually, it is well known that it is difficult to keep high fast neutron reduction power of PSD with the large volume size such as the neutrino reactor monitor. We evaluated the PSD ability of our prototype with real fast neutrons induced by the muons in our laboratory above ground, and we could confirm to keep the high fast neutron reduction power with even our large detector size. (authors)« less

Mobile Assisted Language Learning and Mnemonic Mapping -- The Loci Method Revisited

ERIC Educational Resources Information Center

Waragai, Ikumi; Raindl, Marco; Ohta, Tatsuya; Miyasaka, Kosuke

2016-01-01

This paper presents the prototype of a Mobile Language Learning Environment (MLLE) allowing learners of German at a Japanese university to map classroom learning content onto the pathways of their everyday lives, turning places they come by into mnemonic "loci", and thus changing their daily commute into a learning trail. Even though the…

Grob aircraft construction: The G 110 flies

NASA Technical Reports Server (NTRS)

Malzbender, B.

1982-01-01

Description, specifications and test flight performance of the G 110 are provided. The G 110 completely incorporates modern GfK construction techniques which heretofore have been developed and perfected for the construction of sailplanes. The G 110 is a prototype of a GfK constructed motorized aircraft and shows much promise for the future of German aviation.

Mobile Learning Analytics in Higher Education: Usability Testing and Evaluation of an APP Prototype

ERIC Educational Resources Information Center

Kuhnel, Matthias; Seiler, Luisa; Honal, Andrea; Ifenthaler, Dirk

2017-01-01

This study aims to test the usability of MyLA (My Learning Analytics), an application for students at two German universities: The Cooperative State University Mannheim and University of Mannheim. The participating universities focus on the support of personalized and self-regulated learning. MyLA collects data such as learning behavior and…

BROWSER: An Automatic Indexing On-Line Text Retrieval System. Annual Progress Report.

ERIC Educational Resources Information Center

Williams, J. H., Jr.

The development and testing of the Browsing On-line With Selective Retrieval (BROWSER) text retrieval system allowing a natural language query statement and providing on-line browsing capabilities through an IBM 2260 display terminal is described. The prototype system contains data bases of 25,000 German language patent abstracts, 9,000 English…

[Prevalence of dementia of insured persons with and without German citizenship : A study based on statuatory health insurance data].

PubMed

Stock, Stephanie; Ihle, Peter; Simic, Dusan; Rupprecht, Christoph; Schubert, Ingrid; Lappe, Veronika; Kalbe, Elke; Tebest, Ralf; Lorrek, Kristina

2018-04-01

Elderly people with a non-German background are a fast growing population in Germany. Is administrative prevalence of dementia and uptake of nursing-home care similar in the German and non-German insured? Based on routine data, administrative prevalence rates for dementia were calculated for 2013 from a full census of data from one large sickness fund. Patients with dementia (PWD) were identified via ICD-10 codes (F00; F01; F03; F05; G30). Administrative prevalence of dementia was 2.67% in the study population; 3.06% in Germans, and 0.96% in non-Germans (p value <0.001). Age and sex adjusted prevalence was comparable in the insured with and without German citizenship, except in women aged 80-84 (17.2 vs. 15.4) and for men in the age groups 80-84 (16.5 vs. 14.2), 85-89 years (23.4 vs. 21.5), and above 90 years of age (32.3 vs. 26.3). Standardized to the population of all investigated insured, 31.4% of all Germans with dementia had no longterm care entitlement vs. 35.5% of all patients without German citizenship. Of German patients, 55.1% were institutionalized vs. 39.5% of all patients without German citizenship. There was a higher prevalence of dementia in the very old insured without German citizenship compared to those with German citizenship, especially in men. Non-Germans showed lower uptake of nursing home care compared to Germans. Additionally, Germans had slightly higher nursing care entitlements. It should be investigated further how much of the difference is due to underdiagnosis, cultural differences, or lack of adequate diagnostic work-up.

Using EO-1 Hyperion Images to Prototype Environmental Products for Hyspiri

NASA Technical Reports Server (NTRS)

Middleton, Elizabeth M.; Campbell, Petya K. E.; Ungar, Stephen G.; Ong, Lawrence; Zhang, Qingyuan; Huemmrich, K. Fred; Mandl, Daniel J.; Frye, Stuart W.

2011-01-01

In November 2010, the Earth Observing One (EO-1) Satellite Mission will successfully complete a decade of Earth imaging by its two unique instruments, the Hyperion and the Advanced Land Imager (ALI). Both instruments are serving as prototypes for new orbital sensors, and the EO-1 is a heritage platform for the upcoming German mission, EnMAP. We provide an overview of the mission's lifetime. We briefly describe calibration & validation activities and overview the technical and scientific accomplishments of this mission. Some examples of the Mission Science Office (MSO) products are provided, as is an example of a image collected for disaster monitoring.

Design and fabrication of prototype 6×6 cm 2 microchannel plate photodetector with bialkali photocathode for fast timing applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Junqi; Byrum, Karen; Demarteau, Marcel

Planar microchannel plate-based photodetector with bialkali photocathode is capable of fast and accurate time and position resolutions. A new 6 cm x 6 cm photodetector production facility was designed and built at Argonne National Laboratory. Small form-factor MCP-based photodetectors completely constructed of glass were designed and prototypes were successfully fabricated. Knudsen effusion cells were incorporated in the photocathode growth chamber to achieve uniform and high quantum efficiency hotocathodes. The thin film uniformity distribution was simulated and measured for an antimony film deposition, showing uniformity of better than 10%. Several prototype devices with bialkali photocathodes have been fabricated with the describedmore » system and their characteristics were evaluated in the large signal (multi-PE) limit. A typical prototype device exhibits time-of-flight resolution of ~ 27 psec and differential time resolution of ~ 9 psec, corresponding to spatial resolution of ~ 0.65 mm.« less

Initial results of the FUSION-X-US prototype combining 3D automated breast ultrasound and digital breast tomosynthesis.

PubMed

Schaefgen, Benedikt; Heil, Joerg; Barr, Richard G; Radicke, Marcus; Harcos, Aba; Gomez, Christina; Stieber, Anne; Hennigs, André; von Au, Alexandra; Spratte, Julia; Rauch, Geraldine; Rom, Joachim; Schütz, Florian; Sohn, Christof; Golatta, Michael

2018-06-01

To determine the feasibility of a prototype device combining 3D-automated breast ultrasound (ABVS) and digital breast tomosynthesis in a single device to detect and characterize breast lesions. In this prospective feasibility study, the FUSION-X-US prototype was used to perform digital breast tomosynthesis and ABVS in 23 patients with an indication for tomosynthesis based on current guidelines after clinical examination and standard imaging. The ABVS and tomosynthesis images of the prototype were interpreted separately by two blinded experts. The study compares the detection and BI-RADS® scores of breast lesions using only the tomosynthesis and ABVS data from the FUSION-X-US prototype to the results of the complete diagnostic workup. Image acquisition and processing by the prototype was fast and accurate, with some limitations in ultrasound coverage and image quality. In the diagnostic workup, 29 solid lesions (23 benign, including three cases with microcalcifications, and six malignant lesions) were identified. Using the prototype, all malignant lesions were detected and classified as malignant or suspicious by both investigators. Solid breast lesions can be localized accurately and fast by the Fusion-X-US system. Technical improvements of the ultrasound image quality and ultrasound coverage are needed to further study this new device. The prototype combines tomosynthesis and automated 3D-ultrasound (ABVS) in one device. It allows accurate detection of malignant lesions, directly correlating tomosynthesis and ABVS data. The diagnostic evaluation of the prototype-acquired data was interpreter-independent. The prototype provides a time-efficient and technically reliable diagnostic procedure. The combination of tomosynthesis and ABVS is a promising diagnostic approach.

An application framework for computer-aided patient positioning in radiation therapy.

PubMed

Liebler, T; Hub, M; Sanner, C; Schlegel, W

2003-09-01

The importance of exact patient positioning in radiation therapy increases with the ongoing improvements in irradiation planning and treatment. Therefore, new ways to overcome precision limitations of current positioning methods in fractionated treatment have to be found. The Department of Medical Physics at the German Cancer Research Centre (DKFZ) follows different video-based approaches to increase repositioning precision. In this context, the modular software framework FIVE (Fast Integrated Video-based Environment) has been designed and implemented. It is both hardware- and platform-independent and supports merging position data by integrating various computer-aided patient positioning methods. A highly precise optical tracking system and several subtraction imaging techniques have been realized as modules to supply basic video-based repositioning techniques. This paper describes the common framework architecture, the main software modules and their interfaces. An object-oriented software engineering process has been applied using the UML, C + + and the Qt library. The significance of the current framework prototype for the application in patient positioning as well as the extension to further application areas will be discussed. Particularly in experimental research, where special system adjustments are often necessary, the open design of the software allows problem-oriented extensions and adaptations.

The Influence of Memory on Perception: It's Not What Things Look Like, It's What You Call Them

ERIC Educational Resources Information Center

Mitterer, Holger; Horschig, Jorn M.; Musseler, Jochen; Majid, Asifa

2009-01-01

World knowledge influences how we perceive the world. This study shows that this influence is at least partly mediated by declarative memory. Dutch and German participants categorized hues from a yellow-to-orange continuum on stimuli that were prototypically orange or yellow and that were also associated with these color labels. Both groups gave…

Familiar Verbs Are Not Always Easier than Novel Verbs: How German Pre-School Children Comprehend Active and Passive Sentences

ERIC Educational Resources Information Center

Dittmar, Miriam; Abbot-Smith, Kirsten; Lieven, Elena; Tomasello, Michael

2014-01-01

Many studies show a developmental advantage for transitive sentences with familiar verbs over those with novel verbs. It might be that once familiar verbs become entrenched in particular constructions, they would be more difficult to understand (than would novel verbs) in non-prototypical constructions. We provide support for this hypothesis…

A mercuric iodide detector system for X-ray astronomy. II - Results from flight tests of a balloon borne instrument

NASA Technical Reports Server (NTRS)

Vallerga, J. V.; Vanderspek, R. K.; Ricker, G. R.

1983-01-01

To establish the expected sensitivity of a new hard X-ray telescope design, described by Ricker et al., an experiment was conducted to measure the background counting rate at balloon altitudes (40 km) of mercuric iodide, a room temperature solid state X-ray detector. The prototype detector consisted of two thin mercuric iodide (HgI2) detectors surrounded by a large bismuth germanate scintillator operated in anticoincidence. The bismuth germanate shield vetoed most of the background counting rate induced by atmospheric gamma-rays, neutrons and cosmic rays. A balloon-borne gondola containing a prototype detector assembly was designed, constructed and flown twice in the spring of 1982 from Palestine, TX. The second flight of this instrument established a differential background counting rate of 4.2 + or - 0.7 x 10 to the -5th counts/s sq cm keV over the energy range of 40-80 keV. This measurement was within 50 percent of the predicted value. The measured rate is about 5 times lower than previously achieved in shielded NaI/CsI or Ge systems operating in the same energy range.

Resilient, overcontrolled, and undercontrolled personality prototypes in childhood: replicability, predictive power, and the trait-type issue.

PubMed

Asendorpf, J B; van Aken, M A

1999-10-01

In a longitudinal study, Q-sort patterns of German preschool children were analyzed for personality prototypes and related to developmental outcomes up to age 12. Q-factor analyses confirmed 3 prototypic patterns that showed a high continuity and cross-judge consistency; were similar to those found for North American, Dutch, and Icelandic children; and can be interpreted as resilient, overcontrolled, and undercontrolled. Relations reported by R. W. Robins, O. P. John, A. Caspi, T. E. Moffitt, & M. Stouthamer-Loeber (1996) between these 3 patterns and the Big Five were fully replicated. Growth curve analyses showed that the 3 patterns predicted important developmental outcomes in both the social and the cognitive domains. Evidence was found for both traits and types: A continuous dimension of resiliency bifurcates in its lower part into two relatively discrete personality types, overcontrollers and undercontrollers.

Atmospheric limb sounding with imaging FTS

NASA Astrophysics Data System (ADS)

Friedl-Vallon, Felix; Riese, Martin; Preusse, Peter; Oelhaf, Hermann; Fischer, Herbert

Imaging Fourier transform spectrometers in the thermal infrared are a promising new class of sensors for atmospheric science. The availability of fast and sensitive large focal plane arrays with appropriate spectral coverage in the infrared region allows the conception and construction of innovative sensors for Nadir and Limb geometry. Instruments in Nadir geometry have already reached prototype status (e.g. Geostationary Imaging Fourier Transform Spectrometer / U. Wisconsin and NASA) or are in Phase A study (infrared sounding mission on Meteosat third generation / ESA and EUMETSAT). The first application of the new technical possibilities to atmospheric limb sounding from space, the Imaging Michelson Interferometer for Passive Atmospheric Sounding (IMIPAS), is currently studied by industry in the context of preparatory work for the next set of ESA earth explorers. The scientific focus of the instrument is on the processes controlling the composition of the mid/upper troposphere and lower stratosphere. The instrument concept of IMIPAS has been conceived at the research centres Karlsruhe and J¨lich. The development of a precursor instrument (GLORIA-AB) at these research institutions u started already in 2005. The instrument will be able to fly on board of various airborne platforms. First scientific missions are planned for the second half of the year 2009 on board the new German research aircraft HALO. This airborne sensor serves its own scientific purpose, but it also provides a test bed to learn about this new instrument class and its peculiarities and to learn to exploit and interpret the wealth of information provided by a limb imaging IR Fourier transform spectrometer. The presentation will discuss design considerations and challenges for GLORIA-AB and put them in the context of the planned satellite application. It will describe the solutions found, present first laboratory figures of merit for the prototype instrument and outline the new scientific possibilities.

An Ultrasonic Scanning Technique for In-Situ `Bowing' Measurement of Prototype Fast Breeder Reactor Fuel Sub-Assembly

NASA Astrophysics Data System (ADS)

Swaminathan, K.; Asokane, C.; Sylvia, J. I.; Kalyanasundaram, P.; Swaminathan, P.

2012-02-01

An ultrasonic under-sodium scanner has been developed for deployment in Prototype Fast Breeder Reactor (PFBR) which is in advanced stage of construction at Kalpakkam, India. Its purpose is to scan the above-core plenum for detection, if any, of displacement of sub-assemblies. During its burn-up in the reactor, the head of a Fuel Sub-Assembly (FSA) may undergo a lateral shift from its original position (called `bowing') due to the fast neutron induced damage on its structural material. A simple scanning technique has been developed for measuring the extent of bowing in-situ. This paper describes a PC-controlled mock-up of the scanner used to implement the scanning technique and the results obtained of scanning a mock-up FSA head under water. The details of the liquid-sodium proof transducer developed for use in the PFBR scanner and its performance are also discussed.

A HIGH BANDWIDTH BIPOLAR POWER SUPPLY FOR THE FAST CORRECTORS IN THE APS UPGRADE*

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Ju; Sprau, Gary

The APS Upgrade of a multi-bend achromat (MBA) storage ring requires a fast bipolar power supply for the fast correction magnets. The key performance requirement of the power supply includes a small-signal bandwidth of 10 kHz for the output current. This requirement presents a challenge to the design because of the high inductance of the magnet load and a limited input DC voltage. A prototype DC/DC power supply utilizing a MOSFET H-bridge circuit with a 500 kHz PWM has been developed and tested successfully. The prototype achieved a 10-kHz bandwidth with less than 3-dB attenuation for a signal 0.5% ofmore » the maximum operating current of 15 amperes. This paper presents the design of the power circuit, the PWM method, the control loop, and the test results.« less

Fast, Deep-Record-Length, Fiber-Coupled Photodiode Imaging Array for Plasma Diagnostics

NASA Astrophysics Data System (ADS)

Brockington, Samuel; Case, Andrew; Witherspoon, F. Douglas

2014-10-01

HyperV Technologies has been developing an imaging diagnostic comprised of an array of fast, low-cost, long-record-length, fiber-optically-coupled photodiode channels to investigate plasma dynamics and other fast, bright events. By coupling an imaging fiber bundle to a bank of amplified photodiode channels, imagers and streak imagers of 100 to 1000 pixels can be constructed. By interfacing analog photodiode systems directly to commercial analog-to-digital converters and modern memory chips, a prototype 100 pixel array with an extremely deep record length (128 k points at 20 Msamples/s) and 10 bit pixel resolution has already been achieved. HyperV now seeks to extend these techniques to construct a prototype 1000 Pixel framing camera with up to 100 Msamples/sec rate and 10 to 12 bit depth. Preliminary experimental results as well as Phase 2 plans will be discussed. Work supported by USDOE Phase 2 SBIR Grant DE-SC0009492.

A mercuric detector system for X-ray astronomy. 2. Results from flight tests of a balloon borne instrument

NASA Technical Reports Server (NTRS)

Vallerga, J.; Vanderspek, R. K.; Ricker, G. R.

1982-01-01

To establish the expected sensitivity of a new hard X-ray telescope design, an experiment was conducted to measure the background counting rate at balloon altitudes (40 km) of mercuric iodide, a room temperature solid state X-ray detector. The prototype detector consisted of two thin mercuric iodide (HgI2) detectors surrounded by a large bismuth germanate (Bi4Ge3O12) scintillator operated in anticoincidence. The bismuth germanate shield vetoed most of the background counting rate induced by atmospheric gamma-rays, neutrons and cosmic rays. A balloon-borne gondola containing a prototype detector assembly was designed, constructed and flown twice in the spring of 1982 from Palestine, Texas. The second flight of this instrument established a differential background counting rate of 4.2 O.7 x 10-5 counts/sec cm keV over the energy range of 40 to 80 keV. This measurement was within 50% of the predicted value. The measured rate is approx 5 times lower than previously achieved in shielded NaI/CsI or Ge systems operating in the same energy range. The prediction was based on a Monte Carlo simulation of the detector assembly in the radiation environment at float altitude.

Standing Fast: German Defensive Doctrine on the Russian Front During the Second World War.

DTIC Science & Technology

1983-06-03

von Kluge, Hitler explained that the demands of other fronts (especially Italy) required the transfer of perhaps ’ b| ’P q . . • .,,, -’ ’’’ ’’’ h ...historians such as Heinrich von Treitschke , who regarded past military glory as the wellspring of German nationalism. One of the most onerous aspects of the...Prince Wilhelm of Germany , !.L War Experiences (London: Hurst * and Blackett, 1923), p. 267. " 8See, for example, "General Von Maur’s Memorandum on

A Prototype of Reflection Pulse Oximeter Designed for Mobile Healthcare.

PubMed

Lu, Zhiyuan; Chen, Xiang; Dong, Zhongfei; Zhao, Zhangyan; Zhang, Xu

2016-09-01

This paper introduces a pulse oximeter prototype designed for mobile healthcare. In this prototype, a reflection pulse oximeter is embedded into the back cover of a smart handheld device to offer the convenient measurement of both heart rate (HR) and SpO2 (estimation of arterial oxygen saturation) for home or mobile applications. Novel and miniaturized circuit modules including a chopper network and a filtering amplifier were designed to overcome the influence of ambient light and interferences that are caused by embedding the sensor into a flat cover. A method based on adaptive trough detection for improved HR and SpO2 estimation is proposed with appropriate simplification for its implementation on mobile devices. A fast and effective photoplethysmogram validation scheme is also proposed. Clinical experiments have been carried out to calibrate and test our oximeter. Our prototype oximeter can achieve comparable performance to a clinical oximeter with no significant difference revealed by paired t -tests ( p = 0.182 for SpO2 measurement and p = 0.496 for HR measurement). The design of this pulse oximeter will facilitate fast and convenient measurement of SpO2 for mobile healthcare.

Compact, cost-effective and field-portable microscope prototype based on MISHELF microscopy

NASA Astrophysics Data System (ADS)

Sanz, Martín; Picazo-Bueno, José Ángel; Granero, Luis; García, Javier; Micó, Vicente

2017-02-01

We report on a reduced cost, portable and compact prototype design of lensless holographic microscope with an illumination/detection scheme based on wavelength multiplexing, working with single hologram acquisition and using a fast convergence algorithm for image processing. All together, MISHELF (initials coming from Multi-Illumination Single-Holographic-Exposure Lensless Fresnel) microscopy allows the recording of three Fresnel domain diffraction patterns in a single camera snap-shot incoming from illuminating the sample with three coherent lights at once. Previous implementations have proposed an illumination/detection procedure based on a tuned (illumination wavelengths centered at the maximum sensitivity of the camera detection channels) configuration but here we report on a detuned (non-centered ones) scheme resulting in prototype miniaturization and cost reduction. Thus, MISHELF microscopy in combination with a novel and fast iterative algorithm allows high-resolution (μm range) phase-retrieved (twin image elimination) quantitative phase imaging of dynamic events (video rate recording speed). The performance of this microscope prototype is validated through experiments using both amplitude (USAF resolution test) and complex (live swine sperm cells and flowing microbeads) samples. The proposed method becomes in an alternative instrument improving some capabilities of existing lensless microscopes.

Compact, cost-effective and field-portable microscope prototype based on MISHELF microscopy

PubMed Central

Sanz, Martín; Picazo-Bueno, José Ángel; Granero, Luis; García, Javier; Micó, Vicente

2017-01-01

We report on a reduced cost, portable and compact prototype design of lensless holographic microscope with an illumination/detection scheme based on wavelength multiplexing, working with single hologram acquisition and using a fast convergence algorithm for image processing. All together, MISHELF (initials coming from Multi-Illumination Single-Holographic-Exposure Lensless Fresnel) microscopy allows the recording of three Fresnel domain diffraction patterns in a single camera snap-shot incoming from illuminating the sample with three coherent lights at once. Previous implementations have proposed an illumination/detection procedure based on a tuned (illumination wavelengths centered at the maximum sensitivity of the camera detection channels) configuration but here we report on a detuned (non-centered ones) scheme resulting in prototype miniaturization and cost reduction. Thus, MISHELF microscopy in combination with a novel and fast iterative algorithm allows high-resolution (μm range) phase-retrieved (twin image elimination) quantitative phase imaging of dynamic events (video rate recording speed). The performance of this microscope prototype is validated through experiments using both amplitude (USAF resolution test) and complex (live swine sperm cells and flowing microbeads) samples. The proposed method becomes in an alternative instrument improving some capabilities of existing lensless microscopes. PMID:28233829

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoke, Anderson; Shirazi, Mariko; Chakraborty, Sudipta

As deployment of power electronic coupled generation such as photovoltaic (PV) systems increases, grid operators have shown increasing interest in calling on inverter-coupled generation to help mitigate frequency contingency events by rapidly surging active power into the grid. When responding to contingency events, the faster the active power is provided, the more effective it may be for arresting the frequency event. This paper proposes a predictive PV inverter control method for very fast and accurate control of active power. This rapid active power control method will increase the effectiveness of various higher-level controls designed to mitigate grid frequency contingency events,more » including fast power-frequency droop, inertia emulation, and fast frequency response, without the need for energy storage. The rapid active power control method, coupled with a maximum power point estimation method, is implemented in a prototype PV inverter connected to a PV array. The prototype inverter's response to various frequency events is experimentally confirmed to be fast (beginning within 2 line cycles and completing within 4.5 line cycles of a severe test event) and accurate (below 2% steady-state error).« less

Rapidly prototyped three-dimensional nanofluidic channel networks in glass substrates.

PubMed

Ke, Kevin; Hasselbrink, Ernest F; Hunt, Alan J

2005-08-15

Microfluidic and nanofluidic technologies have long sought a fast, reliable method to overcome the creative limitations of planar fabrication methods, the resolution limits of lithography, and the materials limitations for fast prototyping. In the present work, we demonstrate direct 3D machining of submicrometer diameter, subsurface fluidic channels in glass, via optical breakdown near critical intensity, using a femtosecond pulsed laser. No postexposure etching or bonding is required; the channel network (or almost any arbitrary-shaped cavity below the surface) is produced directly from "art-to-part". The key to this approach is to use very low energy, highly focused, pulses in the presence of liquid. Microbubbles that result from laser energy deposition gently expand and extrude machining debris from the channels. These bubbles are in a highly damped, low Reynolds number regime, implying that surface spalling due to bubble collapse is unimportant. We demonstrate rapid prototyping of three-dimensional "jumpers", mixers, and other key components of complex 3D microscale analysis systems in glass substrates.

Germany's Failure to Achieve an Atomic Bomb in World War II: Bad Science,Good Intentions or Neither?

NASA Astrophysics Data System (ADS)

Lustig, Harry

2004-05-01

This is a progress report on a project to find a definitive answer to the disputed question why the Germans did not succeed in building an atomic bomb. The most extreme answers among those that have been put forward are, on the one hand, that Werner Heisenberg did not understand the difference between a nuclear reactor and a bomb and, on the other, that German scientists dragged their feet because they wanted to deny this weapon of mass destruction to Hitler. From an examination of a number of the German scientific reports on their Uranium Project and of other sources, it seems evident that any early idea of a bomb being a run-away reactor was soon replaced by the realization that a bomb required fast neutrons and close to pure uranium 235. As for the hypothesis that the scruples of German scientists played a significant role in preventing a German atomic bomb, the available records appear to negate that explanation as well. Rather, the minuscule resources devoted to the project, the lack of German industrial capacity, the poorly organized and decentralized organization of the research, and the modus operandi of researchers, including Heisenberg, of simultaneously pursuing other interests, doomed the prospect of getting a bomb.

'Fast-track' colonic surgery in Austria and Germany--results from the survey on patterns in current perioperative practice.

PubMed

Hasenberg, T; Keese, M; Längle, F; Reibenwein, B; Schindler, K; Herold, A; Beck, G; Post, S; Jauch, K W; Spies, C; Schwenk, W; Shang, E

2009-02-01

'Fast-track' rehabilitation has been shown to accelerate recovery, reduce general morbidity and decrease hospital stay after elective colonic surgery. Despite this evidence, there is no information on the acceptance and utilization of these concepts among the entirety of Austrian and German surgeons. In 2006, a questionnaire concerning perioperative routines in elective, open colonic resection was sent to the chief surgeons of 1270 German and 120 Austrian surgical centres. The response rate was 63% in Austria (76 centres) and 30% in Germany (385 centres). Mechanical bowel preparation is used by the majority (Austria, 91%; Germany, 94%); the vertical incision is the standard method of approach to the abdomen in Austria (79%) and Germany (83%), nasogastric decompression tubes are rarely used, one-third of the questioned surgeons in both countries use intra-abdominal drains. Half of the surgical centres allow the intake of clear fluids on the day of surgery and one-fifth offer solid food on that day. Epidural analgesia is used in three-fourths of the institutions. Although there is an evident benefit of fast-track management, the survey shows that they are not yet widely used as a routine in Austria and Germany.

Hypersensitivity of bronchial asthmatics to cockroach in Taiwan. comparative study between American and German cockroaches.

PubMed

Tsai, J J; Kao, M H; Wu, C H

1998-11-01

This study was performed to test the hypersensitivity of asthmatics to American and German cockroaches, which are both common in Taiwan. A total of 236 asthmatic patients received skin prick test using allergen extracts from both American and German cockroaches, and 596 sera from asthmatic patients were analyzed for their specific IgE against German cockroach extract. The results of skin test showed that 39.4 and 36.4% asthmatic patients were hypersensitive to American and German cockroaches. Fifteen among 236 patients were only allergic to American cockroaches and 8 were only allergic to German cockroaches. Using the Pharmacia CAP system, 36% of the sera were found to contain the specific IgE to German cockroach extract. Eighty-nine sera positive for German cockroach extract were then tested for their reactivity to American cockroach extract using the fluoroallergosorbent test (FAST). Sixty among 89 (68%) of their sera contained American cockroach-specific IgE. The correlation coefficient between both parameters was r = 0.45. Immunoblot and immunoblot inhibition studies were performed to analyze the IgE-binding components and the cross-reactivity between American and German cockroaches. The results showed that there are different IgE-binding components between American and German cockroaches. Sera containing specific IgE to both species of cockroach were absorbed with both species of cockroach extracts. The specific IgE to German cockroaches can be absorbed by American cockroach extract in all selected sera and the specific IgE to American cockroaches can only partially be absorbed by German cockroaches. The nonabsorbed allergens in American cockroaches had molecular weights of 33 and 50 kD. In conclusion, one-third of the asthmatic population tested was allergic to cockroaches. Although most cockroach-hypersensitive patients were allergic to both American and German cockroaches, more asthmatic patients were allergic to American cockroaches in Taiwan. The use of non-crossreacting allergen in detecting American cockroach-specific IgE might be important not only for the diagnosis and treatment of cockroach hypersensitivity in asthmatics but also for the differentiation between German and American cockroach hypersensitivity.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, S.R.

A comprehensive evaluation was conducted of the radiation protection practices and programs at prototype LMFBRs with long operational experience. Installations evaluated were the Fast Flux Test Facility (FFTF), Richland, Washington; Experimental Breeder Reactor II (EBR-II), Idaho Falls, Idaho; Prototype Fast Reactor (PFR) Dounreay, Scotland; Phenix, Marcoule, France; and Kompakte Natriumgekuhlte Kernreak Toranlange (KNK II), Karlsruhe, Federal Republic of Germany. The evaluation included external and internal exposure control, respiratory protection procedures, radiation surveillance practices, radioactive waste management, and engineering controls for confining radiation contamination. The theory, design, and operating experience at LMFBRs is described. Aspects of LMFBR health physics different frommore » the LWR experience in the United States are identified. Suggestions are made for modifications to the NRC Standard Review Plan based on the differences.« less

Regenerable biocide delivery unit, volume 2

NASA Technical Reports Server (NTRS)

Atwater, James E.; Wheeler, Richard R., Jr.

1992-01-01

Source code for programs dealing with the following topics are presented: (1) life cycle test stand-parametric test stand control (in BASIC); (2) simultaneous aqueous iodine equilibria-true equilibrium (in C); (3) simultaneous aqueous iodine equilibria-pseudo-equilibrium (in C); (4) pseudo-(fast)-equilibrium with iodide initially present (in C); (5) solution of simultaneous iodine rate expressions (Mathematica); (6) 2nd order kinetics of I2-formic acid in humidity condensate (Mathematica); (7) prototype RMCV onboard microcontroller (CAMBASIC); (8) prototype RAM data dump to PC (in BASIC); and (9) prototype real time data transfer to PC (in BASIC).

No short-term effects of calorie-controlled Mediterranean or fast food dietary interventions on established biomarkers of vascular or metabolic risk in healthy individuals.

PubMed

Parcina, Marijo; Brune, Maik; Kaese, Vareska; Zorn, Markus; Spiegel, Rainer; Vojvoda, Valerija; Fleming, Thomas; Rudofsky, Gottfried; Paul Nawroth, Peter

2015-04-01

This study addressed the question whether the composition of supposedly 'healthy' or 'unhealthy' dietary regimes has a calorie-independent short-term effect on biomarkers of metabolic stress and vascular risk in healthy individuals. Healthy male volunteers (age 29.5 ± 5.9 years, n = 39) were given a standardized baseline diet for two weeks before randomization into three groups of different dietary regimes: fast food, Mediterranean and German cooking style. Importantly, the amount of calories consumed per day was identical in all three groups. Blood samples were analyzed for biomarkers of cardiovascular risk and metabolic stress after two weeks of the baseline diet and after two weeks of the assigned dietary regime. No dietary intervention affected the metabolic or cardiovascular risk profile when compared in-between groups or compared to baseline. Subjects applied to the Mediterranean diet showed a statistically significant increase of uric acid compared to baseline and compared to the German diet group. Plasma concentrations of urea were significantly higher in both the fast food group and the Mediterranean group, when compared to baseline and compared to the German diet group. No significant differences were detected for the levels of vitamins, trace elements or metabolic stress markers (8-hydroxy-2-deoxyguanosine, malondialdehyde and methylglyoxal, a potent glycating agent). Established parameters of vascular risk (e.g. LDL-cholesterol, lipoprotein(a), homocysteine) were not significantly changed in-between groups or compared to baseline during the intervention period. The calorie-controlled dietary intervention caused neither protective nor harmful short-term effects regarding established biomarkers of vascular or metabolic risk. When avoiding the noxious effects of overfeeding, healthy individuals can possess the metabolic capacity to compensate for a potentially disadvantageous composition of a certain diet.

The new ATLAS Fast Calorimeter Simulation

NASA Astrophysics Data System (ADS)

Schaarschmidt, J.; ATLAS Collaboration

2017-10-01

Current and future need for large scale simulated samples motivate the development of reliable fast simulation techniques. The new Fast Calorimeter Simulation is an improved parameterized response of single particles in the ATLAS calorimeter that aims to accurately emulate the key features of the detailed calorimeter response as simulated with Geant4, yet approximately ten times faster. Principal component analysis and machine learning techniques are used to improve the performance and decrease the memory need compared to the current version of the ATLAS Fast Calorimeter Simulation. A prototype of this new Fast Calorimeter Simulation is in development and its integration into the ATLAS simulation infrastructure is ongoing.

Fast-Neutron Survey With Compact Plastic Scintillation Detectors.

PubMed

Preston, Rhys M; Tickner, James R

2017-07-01

With the rise of the Silicon Photomultiplier (SiPM), it is now practical to build compact scintillation detectors well suited to portable use. A prototype survey meter for fast-neutrons and gamma-rays, based around an EJ-299-34 plastic scintillator with SiPM readout, has been developed and tested. A custom digital pulse processor was used to perform pulse shape discrimination on-the-fly. Ambient dose equivalent H*(10) was calculated by means of two energy-dependent 'G-functions'. The sensitivity was calculated to be between 0.10 and 0.22 cps/(µSv/hr) for fast-neutrons with energies above 2.5 MeV. The prototype was used to survey various laboratory radiation fields, with the readings compared with commercial survey meters. The high sensitivity and lightweight nature of this detector makes it promising for rapid survey of the mixed neutron/gamma-ray fields encountered in industry and homeland security. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Investigations of Pressure Distribution on Fast Flying Bodies

NASA Technical Reports Server (NTRS)

Stamm, G.

1946-01-01

The question to be treated is: how high is the pressure in the bow wave caused by a body flying at supersonic speed, and how far reaching are the destructive effects of that wave? The pressure distribution on an s.S. and an S. projectile of normal speed has been ascertained already by the methods of measurement used at the Ballistic Institute of the Technical Academy of the German Air Forces. Now similar investigations of the conditions on especially fast-flying bodies were carried out.

Scintillator tiles read out with silicon photomultipliers

NASA Astrophysics Data System (ADS)

Pooth, O.; Radermacher, T.; Weingarten, S.; Weinstock, L.

2015-10-01

A detector prototype based on a fast plastic scintillator read out with silicon photomultipliers is presented. All studies have been done with cosmic muons and focus on parameter optimization such as coupling the SiPM to the scintillator or wrapping the scintillator with reflective material. The prototype shows excellent results regarding the light-yield and offers a detection efficiency of 99.5% with a signal purity of 99.9% for cosmic muons.

Standing Fast: German Defensive Doctrine on the Russian Front During World War II; Prewar to March 1943,

DTIC Science & Technology

1986-09-01

GmnofesvoealnsMAzovebr192*5 Cacau 5.. . Iv . s . ** .~~~~~~~~~~~ -? %JP~’ 5. . ’ ~f*. * ............................ t’ *S 5%i Soviet forces in place before Moscow.2

Recent advances and plans in processing and geocoding of SAR data at the DFD

NASA Technical Reports Server (NTRS)

Noack, W.

1993-01-01

Because of the needs of future projects like ENVISAT and the experiences made with the current operational ERS-1 facilities, a radical change in the synthetic aperture radar (SAR) processing scenarios can be predicted for the next years. At the German PAF several new developments were initialized which are driven mainly either by user needs or by system and operational constraints ('lessons learned'). At the end there will be a major simplification and uniformation of all used computer systems. Especially the following changes are likely to be implemented at the German PAF: transcription before archiving, processing of all standard products with high throughput directly at the receiving stations, processing of special 'high-valued' products at the PAF, usage of a single type of processor hardware, implementation of a large and fast on-line data archive, and improved and unified fast data network between the processing and archiving facilities. A short description of the current operational SAR facilities as well as the future implementations are given.

METHODS OF CALCULATION FOR THE TREATMENT OF SHIELD HETEROGENEITIES IN THE PROTOTYPE FAST REACTOR.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Broughton, J.; Butler, J.; Brimstone, M.

1969-10-31

The radial shield of the sodium-cooled Prototype Fast Reactor is composed of graphite rods enclosed in steel tubes which are arranged in a lattice of seven rows round the periphery of the breeder. The outside diameter of these rods increases by about a factor of 2 between the inner temperature of about 600 deg C. The dimensions of the steel, graphite and sodium regions are large compared with the mean free paths of the predomination neutrons at intermediate energies; and homogenisation of the shield seriously underestimates the penetration, which is also enhanced by the presence of numerous irregularities associated withmore » nucleonic instrument thimbels, refuelling mechanisms and the primary coolant circuit. Methods of calculation have been developed for the solution of these problems, using both diffusion-theory and Monte Carlo techniques. The diffusion calculations have been accomplished with the COMPRASH and ATTOW codes; and a prototype Monet Carlo code named MOB has been developed, which takes a proper account of the radial shield geometry. The theoretical predictions are compared with measurements made in typical shield arrays on LIDO at Harwell and on the zero-energy fast reactor, ZEBRA, at Winfrith. The diffusion-theory and Monte Carlo approaches are also assessed as design tools taking into consideration accuracy, data preparation and computing time requirements. (auth)« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koh, J. H.; Ng, E. Y. K.; Robertson, Amy

As part of a collaboration of the National Renewable Energy Laboratory (NREL) and SWAY AS, NREL installed scientific wind, wave, and motion measurement equipment on the spar-type 1/6.5th-scale prototype SWAY floating offshore wind system. The equipment enhanced SWAY's data collection and allowed SWAY to verify the concept and NREL to validate a FAST model of the SWAY design in an open-water condition. Nanyang Technological University (NTU), in collaboration with NREL, assisted with the validation. This final report gives an overview of the SWAY prototype and NREL and NTU's efforts to validate a model of the system. The report provides amore » summary of the different software tools used in the study, the modeling strategies, and the development of a FAST model of the SWAY prototype wind turbine, including justification of the modeling assumptions. Because of uncertainty in system parameters and modeling assumptions due to the complexity of the design, several system properties were tuned to better represent the system and improve the accuracy of the simulations. Calibration was performed using data from a static equilibrium test and free-decay tests.« less

Fast-Time Evaluations of Airborne Merging and Spacing in Terminal Arrival Operations

NASA Technical Reports Server (NTRS)

Krishnamurthy, Karthik; Barmore, Bryan; Bussink, Frank; Weitz, Lesley; Dahlene, Laura

2005-01-01

NASA researchers are developing new airborne technologies and procedures to increase runway throughput at capacity-constrained airports by improving the precision of inter-arrival spacing at the runway threshold. In this new operational concept, pilots of equipped aircraft are cleared to adjust aircraft speed to achieve a designated spacing interval at the runway threshold, relative to a designated lead aircraft. A new airborne toolset, prototypes of which are being developed at the NASA Langley Research Center, assists pilots in achieving this objective. The current prototype allows precision spacing operations to commence even when the aircraft and its lead are not yet in-trail, but are on merging arrival routes to the runway. A series of fast-time evaluations of the new toolset were conducted at the Langley Research Center during the summer of 2004. The study assessed toolset performance in a mixed fleet of aircraft on three merging arrival streams under a range of operating conditions. The results of the study indicate that the prototype possesses a high degree of robustness to moderate variations in operating conditions.

Training the Multi-Cultural Manager.

ERIC Educational Resources Information Center

O'Neill, Vincent

A West German electronics corporation designed a workshop to provide managers with fast access to the American culture through the cues provided in American language. The aim was to promote more effective communication with American business partners through sensitization to American communication styles, their principal modes of expression, their…

EO-1/Hyperion: Nearing Twelve Years of Successful Mission Science Operation and Future Plans

NASA Technical Reports Server (NTRS)

Middleton, Elizabeth M.; Campbell, Petya K.; Huemmrich, K. Fred; Zhang, Qingyuan; Landis, David R.; Ungar, Stephen G.; Ong, Lawrence; Pollack, Nathan H.; Cheng, Yen-Ben

2012-01-01

The Earth Observing One (EO-1) satellite is a technology demonstration mission that was launched in November 2000, and by July 2012 will have successfully completed almost 12 years of high spatial resolution (30 m) imaging operations from a low Earth orbit. EO-1 has two unique instruments, the Hyperion and the Advanced Land Imager (ALI). Both instruments have served as prototypes for NASA's newer satellite missions, including the forthcoming (in early 2013) Landsat-8 and the future Hyperspectral Infrared Imager (HyspIRI). As well, EO-1 is a heritage platform for the upcoming German satellite, EnMAP (2015). Here, we provide an overview of the mission, and highlight the capabilities of the Hyperion for support of science investigations, and present prototype products developed with Hyperion imagery for the HyspIRI and other space-borne spectrometers.

Using off-the-shelf medical devices for biomedical signal monitoring in a telemedicine system for emergency medical services.

PubMed

Thelen, Sebastian; Czaplik, Michael; Meisen, Philipp; Schilberg, Daniel; Jeschke, Sabina

2015-01-01

In order to study new methods of telemedicine usage in the context of emergency medical services, researchers need to prototype integrated telemedicine systems. To conduct a one-year trial phase-intended to study a new application of telemedicine in German emergency medical services-we used off-the-shelf medical devices and software to realize real-time patient monitoring within an integrated telemedicine system prototype. We demonstrate its feasibility by presenting the integrated real-time patient monitoring solution, by studying signal delay and transmission robustness regarding changing communication channel characteristics, and by evaluating issues reported by the physicians during the trial phase. Where standards like HL7 and the IEEE 11073 family are intended to enable interoperability of product grade medical devices, we show that research prototypes benefit from the use of web technologies and simple device interfaces, as they simplify product development for a manufacturer and ease integration efforts for research teams. Embracing this approach for the development of new medical devices eases the constraint to use off-the-shelf products for research trials investigating innovative use of telemedicine.

Social medicine vs professional dominance: the German experience.

PubMed Central

Light, D W; Liebfried, S; Tennstedt, F

1986-01-01

This article describes the efforts by German workers' groups and pioneering social physicians to design health care services oriented to prevention and cost-effective treatment. Jews played a key role in developing these prototypes of today's health maintenance organizations (HMOs) and preferred provider organizations (PPOs). The growing success of these services threatened private practitioners in a number of ways. They formed a trade union and took militant action. Stage by stage, the profession asserted its dominance, culminating in an alliance with the National Socialists and Hitler to take over these services and to purge them of socialist and Jewish physicians. Medical societies assisted Hitler in his policies of "purification," and the health care delivery systems shifted from being local, patient-centered, and health-oriented to being national, physician-centered, and focused on curing illness. After World War II, these changes were not reversed as part of denazification, and 40 years later, social medicine has yet to recover. PMID:3510052

Simulation of German PKL refill/reflood experiment K9A using RELAP4/MOD7. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsu, M.T.; Davis, C.B.; Behling, S.R.

This paper describes a RELAP4/MOD7 simulation of West Germany's Kraftwerk Union (KWU) Primary Coolant Loop (PKL) refill/reflood experiment K9A. RELAP4/MOD7, a best-estimate computer program for the calculation of thermal and hydraulic phenomena in a nuclear reactor or related system, is the latest version in the RELAP4 code development series. This study was the first major simulation using RELAP4/MOD7 since its release by the Idaho National Engineering Laboratory (INEL). The PKL facility is a reduced scale (1:134) representation of a typical West German four-loop 1300 MW pressurized water reactor (PWR). A prototypical scale of the total volume to power ratio wasmore » maintained. The test facility was designed specifically for an experiment simulating the refill/reflood phase of a Loss-of-Coolant Accident (LOCA).« less

[Strength and weaknesses of the German digital health economy].

PubMed

Leppert, Florian; Gerlach, Jan; Ostwald, Dennis A; Greiner, Wolfgang

2017-07-26

There are high expectations from digitalization of health care, ehealth and telemedicine. Nevertheless, the diffusion of these services falls short of expectations. This study analyses the strength and weaknesses of the German digital health economy. Thereby, we specially focus on small and medium-sized enterprises (SME). The study is based on a literature review, interviews of experts and a workshop. The digital health economy is influenced by a heterogeneous environment with both promotive and obstructive factors. One of the largest weaknesses results from a lack of business models. There is a lack of possibilities of reimbursement by the Statutory Health Insurance (SHI). In addition, private users only have a small willingness to pay for digital services. The large number of regulations makes the implementation even harder, especially for SMEs. Thus, the current environment hampers fast diffusion of digital services in the German health care market. © Georg Thieme Verlag KG Stuttgart · New York.

Internationally comparable screening tests for listening in noise in several European languages: the German digit triplet test as an optimization prototype.

PubMed

Zokoll, Melanie A; Wagener, Kirsten C; Brand, Thomas; Buschermöhle, Michael; Kollmeier, Birger

2012-09-01

A review is given of internationally comparable speech-in-noise tests for hearing screening purposes that were part of the European HearCom project. This report describes the development, optimization, and evaluation of such tests for headphone and telephone presentation, using the example of the German digit triplet test. In order to achieve the highest possible comparability, language- and speaker-dependent factors in speech intelligibility should be compensated for. The tests comprise spoken numbers in background noise and estimate the speech reception threshold (SRT), i.e. the signal-to-noise ratio (SNR) yielding 50% speech intelligibility. The respective reference speech intelligibility functions for headphone and telephone presentation of the German version for 15 and 10 normal-hearing listeners are described by a SRT of -9.3 ± 0.2 and -6.5 ± 0.4 dB SNR, and slopes of 19.6 and 17.9%/dB, respectively. Reference speech intelligibility functions of all digit triplet tests optimized within the HearCom project allow for investigation of the comparability due to language specificities. The optimization criteria established here should be used for similar screening tests in other languages.

U.S. Nuclear Cooperation with India: Issues for Congress

DTIC Science & Technology

2008-11-03

separation list: ! 8 indigenous Indian power reactors ! Fast Breeder test Reactor (FTBR) and Prototype Fast Breeder Reactors (PFBR) under construction...facilities like reprocessing and enrichment plants and breeder reactors could be viewed as providing a significant nonproliferation benefit because the... breeder reactors would support the 2002 U.S. National Strategy to Combat Weapons of Mass Destruction, in which the United States pledged to “continue to

U.S. Nuclear Cooperation with India: Issues for Congress

DTIC Science & Technology

2008-10-17

safeguards-irrelevant.” The following facilities and activities were not on the separation list: ! 8 indigenous Indian power reactors ! Fast Breeder ...test Reactor (FTBR) and Prototype Fast Breeder Reactors (PFBR) under construction ! Enrichment facilities ! Spent fuel reprocessing facilities (except...potential use in a bomb. In addition, safeguards on enrichment, reprocessing plants, and breeder reactors would support the 2002 U.S. National Strategy to

U.S. Nuclear Cooperation with India: Issues for Congress

DTIC Science & Technology

2008-10-02

8 indigenous Indian power reactors ! Fast Breeder test Reactor (FTBR) and Prototype Fast Breeder Reactors (PFBR) under construction ! Enrichment... breeder reactors could be viewed as providing a significant nonproliferation benefit because the materials produced by these plants are a few steps closer...to potential use in a bomb. In addition, safeguards on enrichment, reprocessing plants, and breeder reactors would support the 2002 U.S. National

Operate to Know: An Operational and Intelligence for the Operational Level of War

DTIC Science & Technology

2014-06-13

hazardous about this form of German warfare that became visible over time. 12 As exhilarating as fast-paced shock maneuver was, it left behind...significant uncertainty into his view of Allied intentions. After Dieppe, Hitler moved eight additional divisions into France to beef up the Western

Preliminary Evaluation of a New German Translated Tobacco Quality of Life Impact Tool to Discriminate Between Healthy Current and Former Smokers and to Explore the Effect of Switching Smokers to a Reduced Toxicant Prototype Cigarette.

PubMed

Kulasekaran, Anuradha; Proctor, Christopher; Papadopoulou, Ermioni; Shepperd, Christopher J; Guyer, Rick; Gandek, Barbara; Ware, John E

2015-12-01

Assessment of health-related quality of life (HRQoL) is well established in clinical research, but ceiling effects in validated tools might prevent detection of changes in well respondents. Tobacco Quality of Life Impact Tool (TQOLITv1) uses conceptual and psychometric advances to enhance detection of HRQoL changes. In a 6-month, forced-switch study, the German TQOLITv1 was assessed in healthy adult (age 23-55 years) current and matched former-smokers. At baseline, smokers were switched to reduced toxicant prototype (RTP) or conventional cigarette for 6 months. TQOLITv1 responses were collected at baseline, 3 and 6 months from current smokers whilst former smokers completed it at the latter two time points. TQOLITv1 includes SF-36v2 and new smoking-specific, physical and general-health measures. Reliability at baseline was good (Cronbach's coefficient alpha > 0.70) for all measures. The baseline percentage with the best possible score (ceiling effect) for former and current smokers was substantially better for the new physical function than SF-36 physical function measure (35% vs. 59% at ceiling, respectively). New smoking-specific measures discriminated current from former smokers better than general health measures. Smoking-specific symptoms (r = 0.73) were more stable from baseline to 6 months than other measures (r = 0.38-0.54) particularly more than the SF-36 mental component score (r = 0.24). Although both product smoking groups worsened in most HRQoL measures, changes in general and smoking-specific HRQoL impact measures favored RTP smokers. The German TQOLITv1 is sufficiently reliable and valid to assess HRQoL and may be more useful than SF-36v2 in evaluation of interventions in well smoking populations including those consuming RTPs. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco.

Using 3D Printing for Rapid Prototyping of Characterization Tools for Investigating Powder Blend Behavior.

PubMed

Hirschberg, Cosima; Boetker, Johan P; Rantanen, Jukka; Pein-Hackelbusch, Miriam

2018-02-01

There is an increasing need to provide more detailed insight into the behavior of particulate systems. The current powder characterization tools are developed empirically and in many cases, modification of existing equipment is difficult. More flexible tools are needed to provide understanding of complex powder behavior, such as mixing process and segregation phenomenon. An approach based on the fast prototyping of new powder handling geometries and interfacing solutions for process analytical tools is reported. This study utilized 3D printing for rapid prototyping of customized geometries; overall goal was to assess mixing process of powder blends at small-scale with a combination of spectroscopic and mechanical monitoring. As part of the segregation evaluation studies, the flowability of three different paracetamol/filler-blends at different ratios was investigated, inter alia to define the percolation thresholds. Blends with a paracetamol wt% above the percolation threshold were subsequently investigated in relation to their segregation behavior. Rapid prototyping using 3D printing allowed designing two funnels with tailored flow behavior (funnel flow) of model formulations, which could be monitored with an in-line near-infrared (NIR) spectrometer. Calculating the root mean square (RMS) of the scores of the two first principal components of the NIR spectra visualized spectral variation as a function of process time. In a same setup, mechanical properties (basic flow energy) of the powder blend were monitored during blending. Rapid prototyping allowed for fast modification of powder testing geometries and easy interfacing with process analytical tools, opening new possibilities for more detailed powder characterization.

Foreign Languages Sound Fast: Evidence from Implicit Rate Normalization.

PubMed

Bosker, Hans Rutger; Reinisch, Eva

2017-01-01

Anecdotal evidence suggests that unfamiliar languages sound faster than one's native language. Empirical evidence for this impression has, so far, come from explicit rate judgments. The aim of the present study was to test whether such perceived rate differences between native and foreign languages (FLs) have effects on implicit speech processing. Our measure of implicit rate perception was "normalization for speech rate": an ambiguous vowel between short /a/ and long /a:/ is interpreted as /a:/ following a fast but as /a/ following a slow carrier sentence. That is, listeners did not judge speech rate itself; instead, they categorized ambiguous vowels whose perception was implicitly affected by the rate of the context. We asked whether a bias towards long /a:/ might be observed when the context is not actually faster but simply spoken in a FL. A fully symmetrical experimental design was used: Dutch and German participants listened to rate matched (fast and slow) sentences in both languages spoken by the same bilingual speaker. Sentences were followed by non-words that contained vowels from an /a-a:/ duration continuum. Results from Experiments 1 and 2 showed a consistent effect of rate normalization for both listener groups. Moreover, for German listeners, across the two experiments, foreign sentences triggered more /a:/ responses than (rate matched) native sentences, suggesting that foreign sentences were indeed perceived as faster. Moreover, this FL effect was modulated by participants' ability to understand the FL: those participants that scored higher on a FL translation task showed less of a FL effect. However, opposite effects were found for the Dutch listeners. For them, their native rather than the FL induced more /a:/ responses. Nevertheless, this reversed effect could be reduced when additional spectral properties of the context were controlled for. Experiment 3, using explicit rate judgments, replicated the effect for German but not Dutch listeners. We therefore conclude that the subjective impression that FLs sound fast may have an effect on implicit speech processing, with implications for how language learners perceive spoken segments in a FL.

Design and prototype results of the FAST detector

NASA Astrophysics Data System (ADS)

Mozzanica, A.; Basset, M.; Caccia, M.; Corradini, M.; Leali, M.; Lodi Rizzini, E.; Prest, M.; Venturelli, L.; Vallazza, E.; Zurlo, N.

2006-11-01

A new fiber tracker is being developed for the ASACUSA experiment at the Antiproton Decelerator at CERN. The detector is based on 1 mm diameter scintillating fibers readout by HAMAMATSU 64 channel multianode photomultipliers (MA-PMTs) connected to a dedicated electronic chain. The paper gives a description of the testing procedures for time resolution, spatial resolution and efficiency measurements performed with standard NIM electronics and a commercial TDC and reports the results for different prototype detectors.

Prototype Stilbene Neutron Collar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prasad, M. K.; Shumaker, D.; Snyderman, N.

2016-10-26

A neutron collar using stilbene organic scintillator cells for fast neutron counting is described for the assay of fresh low enriched uranium (LEU) fuel assemblies. The prototype stilbene collar has a form factor similar to standard He-3 based collars and uses an AmLi interrogation neutron source. This report describes the simulation of list mode neutron correlation data on various fuel assemblies including some with neutron absorbers (burnable Gd poisons). Calibration curves (doubles vs 235U linear mass density) are presented for both thermal and fast (with Cd lining) modes of operation. It is shown that the stilbene collar meets or exceedsmore » the current capabilities of He-3 based neutron collars. A self-consistent assay methodology, uniquely suited to the stilbene collar, using triples is described which complements traditional assay based on doubles calibration curves.« less

Design and Testing of a Fast, 50 kV Solid-State Kicker Pulser

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, E G; Hickman, B C; Lee, B S

2002-06-24

The ability to extract particle beam bunches from a ring accelerator in arbitrary order can greatly extend an accelerator's capabilities and applications. A prototype solid-state kicker pulser capable of generating asynchronous bursts of 50 kV pulses has been designed and tested into a 50{Omega} load. The pulser features fast rise and fall times and is capable of generating an arbitrary pattern of pulses with a maximum burst frequency exceeding 5 MHz If required, the pulse-width of each pulse in the burst is independently adjustable. This kicker modulator uses multiple solid-state modules stacked in an inductive-adder configuration where the energy ismore » switched into each section of the adder by a parallel array of MOSFETs. Test data, capabilities, and limitations of the prototype pulser are described.« less

Simulation of pump-turbine prototype fast mode transition for grid stability support

NASA Astrophysics Data System (ADS)

Nicolet, C.; Braun, O.; Ruchonnet, N.; Hell, J.; Béguin, A.; Avellan, F.

2017-04-01

The paper explores the additional services that Full Size Frequency Converter, FSFC, solution can provide for the case of an existing pumped storage power plant of 2x210 MW, for which conversion from fixed speed to variable speed is investigated with a focus on fast mode transition. First, reduced scale model tests experiments of fast transition of Francis pump-turbine which have been performed at the ANDRITZ HYDRO Hydraulic Laboratory in Linz Austria are presented. The tests consist of linear speed transition from pump to turbine and vice versa performed with constant guide vane opening. Then existing pumped storage power plant with pump-turbine quasi homologous to the reduced scale model is modelled using the simulation software SIMSEN considering the reservoirs, penstocks, the two Francis pump-turbines, the two downstream surge tanks, and the tailrace tunnel. For the electrical part, an FSFC configuration is considered with a detailed electrical model. The transitions from turbine to pump and vice versa are simulated, and similarities between prototype simulation results and reduced scale model experiments are highlighted.

Benchmark Evaluation of Dounreay Prototype Fast Reactor Minor Actinide Depletion Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hess, J. D.; Gauld, I. C.; Gulliford, J.

2017-01-01

Historic measurements of actinide samples in the Dounreay Prototype Fast Reactor (PFR) are of interest for modern nuclear data and simulation validation. Samples of various higher-actinide isotopes were irradiated for 492 effective full-power days and radiochemically assayed at Oak Ridge National Laboratory (ORNL) and Japan Atomic Energy Research Institute (JAERI). Limited data were available regarding the PFR irradiation; a six-group neutron spectra was available with some power history data to support a burnup depletion analysis validation study. Under the guidance of the Organisation for Economic Co-Operation and Development Nuclear Energy Agency (OECD NEA), the International Reactor Physics Experiment Evaluation Projectmore » (IRPhEP) and Spent Fuel Isotopic Composition (SFCOMPO) Project are collaborating to recover all measurement data pertaining to these measurements, including collaboration with the United Kingdom to obtain pertinent reactor physics design and operational history data. These activities will produce internationally peer-reviewed benchmark data to support validation of minor actinide cross section data and modern neutronic simulation of fast reactors with accompanying fuel cycle activities such as transportation, recycling, storage, and criticality safety.« less

Development of fast parallel multi-technique scanning X-ray imaging at Synchrotron Soleil

NASA Astrophysics Data System (ADS)

Medjoubi, K.; Leclercq, N.; Langlois, F.; Buteau, A.; Lé, S.; Poirier, S.; Mercère, P.; Kewish, C. M.; Somogyi, A.

2013-10-01

A fast multimodal scanning X-ray imaging scheme is prototyped at Soleil Synchrotron. It permits the simultaneous acquisition of complementary information on the sample structure, composition and chemistry by measuring transmission, differential phase contrast, small-angle scattering, and X-ray fluorescence by dedicated detectors with ms dwell time per pixel. The results of the proof of principle experiments are presented in this paper.

The prototype fast reactor at Dounreay, Scotland. Process and engineering development for sodium removal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mann, A.; Herrick, R.; Gunn, J.

2007-07-01

Dounreay was home to commercial fast reactor development in the UK. Following the construction and operation of the Dounreay Fast Reactor, a sodium-cooled Prototype Fast Reactor (PFR), was constructed. PFR started operating in 1974, closed in 1994 and is presently being decommissioned. To date the bulk of the sodium has been removed and treated. Due to the design of the existing extraction system however, a sodium pool will remain in the heel of the reactor. To remove this sodium, a pump/camera system was developed, tested and deployed. The Water Vapour Nitrogen (WVN) process has been selected to allow removal ofmore » the final sodium residues from the reactor. Due to the design of the reactor and potential for structural damage should Normal WVN (which produces hydrated sodium hydroxide) be used, Low Concentration WVN (LC WVN) has been developed. Pilot scale testing has shown that it is possible treat the reactor within 18 months at a WVN concentration of up to 4% v/v and temperature of 120 deg. C. At present the equipment that will be used to apply LC WVN to the reactor is being developed at the detail design stage. and is expected to be deployed within the next few years. (authors)« less

The Novel Language-Systematic Aphasia Screening SAPS: Screening-Based Therapy in Combination with Computerised Home Training

ERIC Educational Resources Information Center

Krzok, Franziska; Rieger, Verena; Niemann, Katharina; Nobis-Bosch, Ruth; Radermacher, Irmgard; Huber, Walter; Willmes, Klaus; Abel, Stefanie

2018-01-01

Background: SAPS--'Sprachsystematisches Aphasiescreening'--is a novel language-systematic aphasia screening developed for the German language, which already had been positively evaluated. It offers a fast assessment of modality-specific psycholinguistic components at different levels of complexity and the derivation of impairment-based treatment…

Fast Fiber-Coupled Imaging Devices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brockington, Samuel; Case, Andrew; Witherspoon, Franklin Douglas

HyperV Technologies Corp. has successfully designed, built and experimentally demonstrated a full scale 1024 pixel 100 MegaFrames/s fiber coupled camera with 12 or 14 bits, and record lengths of 32K frames, exceeding our original performance objectives. This high-pixel-count, fiber optically-coupled, imaging diagnostic can be used for investigating fast, bright plasma events. In Phase 1 of this effort, a 100 pixel fiber-coupled fast streak camera for imaging plasma jet profiles was constructed and successfully demonstrated. The resulting response from outside plasma physics researchers emphasized development of increased pixel performance as a higher priority over increasing pixel count. In this Phase 2more » effort, HyperV therefore focused on increasing the sample rate and bit-depth of the photodiode pixel designed in Phase 1, while still maintaining a long record length and holding the cost per channel to levels which allowed up to 1024 pixels to be constructed. Cost per channel was 53.31 dollars, very close to our original target of $50 per channel. The system consists of an imaging "camera head" coupled to a photodiode bank with an array of optical fibers. The output of these fast photodiodes is then digitized at 100 Megaframes per second and stored in record lengths of 32,768 samples with bit depths of 12 to 14 bits per pixel. Longer record lengths are possible with additional memory. A prototype imaging system with up to 1024 pixels was designed and constructed and used to successfully take movies of very fast moving plasma jets as a demonstration of the camera performance capabilities. Some faulty electrical components on the 64 circuit boards resulted in only 1008 functional channels out of 1024 on this first generation prototype system. We experimentally observed backlit high speed fan blades in initial camera testing and then followed that with full movies and streak images of free flowing high speed plasma jets (at 30-50 km/s). Jet structure and jet collisions onto metal pillars in the path of the plasma jets were recorded in a single shot. This new fast imaging system is an attractive alternative to conventional fast framing cameras for applications and experiments where imaging events using existing techniques are inefficient or impossible. The development of HyperV's new diagnostic was split into two tracks: a next generation camera track, in which HyperV built, tested, and demonstrated a prototype 1024 channel camera at its own facility, and a second plasma community beta test track, where selected plasma physics programs received small systems of a few test pixels to evaluate the expected performance of a full scale camera on their experiments. These evaluations were performed as part of an unfunded collaboration with researchers at Los Alamos National Laboratory and the University of California at Davis. Results from the prototype 1024-pixel camera are discussed, as well as results from the collaborations with test pixel system deployment sites.« less

Customizable Optical Force Sensor for Fast Prototyping and Cost-Effective Applications.

PubMed

Díez, Jorge A; Catalán, José M; Blanco, Andrea; García-Perez, José V; Badesa, Francisco J; Gacía-Aracil, Nicolás

2018-02-07

This paper presents the development of an optical force sensor architecture directed to prototyping and cost-effective applications, where the actual force requirements are still not well defined or the most suitable commercial technologies would highly increase the cost of the device. The working principle of this sensor consists of determining the displacement of a lens by measuring the distortion of a refracted light beam. This lens is attached to an elastic interface whose elastic constant is known, allowing the estimation of the force that disturbs the optical system. In order to satisfy the requirements of the design process in an inexpensive way, this sensor can be built by fast prototyping technologies and using non-optical grade elements. To deal with the imperfections of this kind of manufacturing procedures and materials, four fitting models are proposed to calibrate the implemented sensor. In order to validate the system, two different sensor implementations with measurement ranges of ±45 N and ±10 N are tested with the proposed models, comparing the resulting force estimation with respect to an industrial-grade load cell. Results show that all models can estimate the loads with an error of about 6% of the measurement range.

Customizable Optical Force Sensor for Fast Prototyping and Cost-Effective Applications

PubMed Central

Díez, Jorge A.; Catalán, José M.; Blanco, Andrea; García-Perez, José V.; Badesa, Francisco J.

2018-01-01

This paper presents the development of an optical force sensor architecture directed to prototyping and cost-effective applications, where the actual force requirements are still not well defined or the most suitable commercial technologies would highly increase the cost of the device. The working principle of this sensor consists of determining the displacement of a lens by measuring the distortion of a refracted light beam. This lens is attached to an elastic interface whose elastic constant is known, allowing the estimation of the force that disturbs the optical system. In order to satisfy the requirements of the design process in an inexpensive way, this sensor can be built by fast prototyping technologies and using non-optical grade elements. To deal with the imperfections of this kind of manufacturing procedures and materials, four fitting models are proposed to calibrate the implemented sensor. In order to validate the system, two different sensor implementations with measurement ranges of ±45 N and ±10 N are tested with the proposed models, comparing the resulting force estimation with respect to an industrial-grade load cell. Results show that all models can estimate the loads with an error of about 6% of the measurement range. PMID:29414861

Depleted fully monolithic CMOS pixel detectors using a column based readout architecture for the ATLAS Inner Tracker upgrade

NASA Astrophysics Data System (ADS)

Wang, T.; Barbero, M.; Berdalovic, I.; Bespin, C.; Bhat, S.; Breugnon, P.; Caicedo, I.; Cardella, R.; Chen, Z.; Degerli, Y.; Egidos, N.; Godiot, S.; Guilloux, F.; Hemperek, T.; Hirono, T.; Krüger, H.; Kugathasan, T.; Hügging, F.; Marin Tobon, C. A.; Moustakas, K.; Pangaud, P.; Schwemling, P.; Pernegger, H.; Pohl, D.-L.; Rozanov, A.; Rymaszewski, P.; Snoeys, W.; Wermes, N.

2018-03-01

Depleted monolithic active pixel sensors (DMAPS), which exploit high voltage and/or high resistivity add-ons of modern CMOS technologies to achieve substantial depletion in the sensing volume, have proven to have high radiation tolerance towards the requirements of ATLAS in the high-luminosity LHC era. DMAPS integrating fast readout architectures are currently being developed as promising candidates for the outer pixel layers of the future ATLAS Inner Tracker, which will be installed during the phase II upgrade of ATLAS around year 2025. In this work, two DMAPS prototype designs, named LF-Monopix and TJ-Monopix, are presented. LF-Monopix was fabricated in the LFoundry 150 nm CMOS technology, and TJ-Monopix has been designed in the TowerJazz 180 nm CMOS technology. Both chips employ the same readout architecture, i.e. the column drain architecture, whereas different sensor implementation concepts are pursued. The paper makes a joint description of the two prototypes, so that their technical differences and challenges can be addressed in direct comparison. First measurement results for LF-Monopix will also be shown, demonstrating for the first time a fully functional fast readout DMAPS prototype implemented in the LFoundry technology.

Prototype Development of the GMT Fast Steering Mirror

NASA Astrophysics Data System (ADS)

Kim, Young-Soo; Koh, J.; Jung, H.; Jung, H.; Cho, M. K.; Park, W.; Yang, H.; Kim, H.; Lee, K.; Ahn, H.; Park, B.

2013-06-01

A Fast Steering Mirror (FSM) is going to be produced as a secondary mirror of the Giant Magellan Telescope (GMT). FSM is 3.2 m in diameter and the focal ratio is 0.65. It is composed of seven circular segments which match with the primary mirror segments. Each segment contains a light-weighted mirror whose diameter is 1.1 m. It also contains tip-tilt actuators which would compensate wind effect and structure jitter. An FSM prototype (FSMP) has been developed, which consists of a full-size off-axis mirror segment and a tip-tilt test-bed. The main purpose of the FSMP development is to achieve key technologies, such as fabrication of highly aspheric off-axis mirror and tip-tilt actuation. The development has been conducted by a consortium of five institutions in Korea and USA, and led by Korea Astronomy and Space Science Institute. The mirror was light-weighted and grinding of the front surface was finished. Polishing is in progress with computer generated hologram tests. The tip-tilt test-bed has been manufactured and assembled. Frequency tests are being performed and optical tilt set-up is arranged for visual demonstration. In this paper, we present progress of the prototype development, and future works.

PRELIMINARY TEST RESULTS OF A PROTOTYPE FAST KICKER FOR APS MBA UPGRADE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yao, C.-Y.; Morrison, L.; Sun, X.

The APS multi-bend achromatic (MBA) upgrade storage ring plans to support two bunch fill patterns: a 48-bunch and a 324-bunch. A “swap out” injection scheme is required. In order to provide the required kick to injected beam, to minimize the beam loss and residual oscillation of injected beam, and to minimize the perturbation to stored beam during injection, the rise, fall, and flat-top parts of the kicker pulse must be within a 16.9-ns interval. Stripline-type kickers are chosen for both injection and extraction. We developed a prototype kicker that supports a ±15kV differential pulse voltage. We performed high voltage discharge,more » TDR measurement, high voltage pulse test and beam test of the kicker. We report the final design of the fast kicker and the test results.« less

A 10MHz Fiber-Coupled Photodiode Imaging Array for Plasma Diagnostics

NASA Astrophysics Data System (ADS)

Brockington, Samuel; Case, Andrew; Witherspoon, F. Douglas

2013-10-01

HyperV Technologies has been developing an imaging diagnostic comprised of arrays of fast, low-cost, long-record-length, fiber-optically-coupled photodiode channels to investigate plasma dynamics and other fast, bright events. By coupling an imaging fiber bundle to a bank of amplified photodiode channels, imagers and streak imagers of 100 to 10,000 pixels can be constructed. By interfacing analog photodiode systems directly to commercial analog to digital convertors and modern memory chips, a prototype pixel with an extremely deep record length (128 k points at 40 Msamples/s) has been achieved for a 10 bit resolution system with signal bandwidths of at least 10 MHz. Progress on a prototype 100 Pixel streak camera employing this technique is discussed along with preliminary experimental results and plans for a 10,000 pixel imager. Work supported by USDOE Phase 1 SBIR Grant DE-SC0009492.

Glycaemic and insulinaemic properties of some German honey varieties.

PubMed

Deibert, P; König, D; Kloock, B; Groenefeld, M; Berg, A

2010-07-01

The glycaemic and insulinaemic response to different German honey varieties have not been studied so far. Eight German honey grades differing in their floral source and carbohydrate composition were tested. Isoglucidic test meals (25 g carbohydrate) and a 25 g glucose reference were given to 10 clinically and metabolically healthy, fasting individuals (31.5+/-8.1 years of age (mean+/-s.d.), two women). Glycaemic and insulinaemic index were calculated by the recommended FAO/WHO measure. Five of the eight tested honey varieties show a low glycaemic index below 55; for six of the eight tested varieties, the glycaemic load was lower than 10 (portion size of 20 g honey). Glycaemic index and insulinaemic index correlated significantly with the fructose content of honey varieties. The results show that glycaemic index and insulinaemic response depend on the fructose content of honey. Therefore, specific honey varieties may be recommended for subjects with impaired glucose tolerance instead of saccharose in food preparations.

High definition clouds and precipitation for climate prediction -results from a unified German research initiative on high resolution modeling and observations

NASA Astrophysics Data System (ADS)

Rauser, F.

2013-12-01

We present results from the German BMBF initiative 'High Definition Cloud and Precipitation for advancing Climate Prediction -HD(CP)2'. This initiative addresses most of the problems that are discussed in this session in one, unified approach: cloud physics, convection, boundary layer development, radiation and subgrid variability are approached in one organizational framework. HD(CP)2 merges both observation and high performance computing / model development communities to tackle a shared problem: how to improve the understanding of the most important subgrid-scale processes of cloud and precipitation physics, and how to utilize this knowledge for improved climate predictions. HD(CP)2 is a coordinated initiative to: (i) realize; (ii) evaluate; and (iii) statistically characterize and exploit for the purpose of both parameterization development and cloud / precipitation feedback analysis; ultra-high resolution (100 m in the horizontal, 10-50 m in the vertical) regional hind-casts over time periods (3-15 y) and spatial scales (1000-1500 km) that are climatically meaningful. HD(CP)2 thus consists of three elements (the model development and simulations, their observational evaluation and exploitation/synthesis to advance CP prediction) and its first three-year phase has started on October 1st 2012. As a central part of HD(CP)2, the HD(CP)2 Observational Prototype Experiment (HOPE) has been carried out in spring 2013. In this campaign, high resolution measurements with a multitude of instruments from all major centers in Germany have been carried out in a limited domain, to allow for unprecedented resolution and precision in the observation of microphysics parameters on a resolution that will allow for evaluation and improvement of ultra-high resolution models. At the same time, a local area version of the new climate model ICON of the Max Planck Institute and the German weather service has been developed that allows for LES-type simulations on high resolutions on limited domains. The advantage of modifying an existing, evolving climate model is to share insights from high resolution runs directly with the large-scale modelers and to allow for easy intercomparison and evaluation later on. Within this presentation, we will give a short overview on HD(CP)2 , show results from the observation campaign HOPE and the LES simulations of the same domain and conditions and will discuss how these will lead to an improved understanding and evaluation background for the efforts to improve fast physics in our climate model.

8-channel prototype of SALT readout ASIC for Upstream Tracker in the upgraded LHCb experiment

NASA Astrophysics Data System (ADS)

Abellan Beteta, C.; Bugiel, S.; Dasgupta, R.; Firlej, M.; Fiutowski, T.; Idzik, M.; Kane, C.; Moron, J.; Swientek, K.; Wang, J.

2017-02-01

SALT is a new 128-channel readout ASIC for silicon strip detectors in the upgraded Upstream Tracker of the LHCb experiment. It will extract and digitise analogue signals from the sensor, perform digital processing and transmit serial output data. SALT is designed in CMOS 130 nm process and uses a novel architecture comprising of an analogue front-end and an ultra-low power (<0.5 mW) fast (40 MSps) sampling 6-bit ADC in each channel. An 8-channel prototype (SALT8), comprising all important functionalities was designed, fabricated and tested. A full 128-channel version was also submitted. The design and test results of the SALT8 prototype are presented showing its full functionality.

Next Generation CTAS Tools

NASA Technical Reports Server (NTRS)

Erzberger, Heinz

2000-01-01

The FAA's Free Flight Phase 1 Office is in the process of deploying the current generation of CTAS tools, which are the Traffic Management Advisor (TMA) and the passive Final Approach Spacing Tool (pFAST), at selected centers and airports. Research at NASA is now focussed on extending the CTAS software and computer human interfaces to provide more advanced capabilities. The Multi-center TMA (McTMA) is designed to operate at airports where arrival flows originate from two or more centers whose boundaries are in close proximity to the TRACON boundary. McTMA will also include techniques for routing arrival flows away from congested airspace and around airspace reserved for arrivals into other hub airports. NASA is working with FAA and MITRE to build a prototype McTMA for the Philadelphia airport. The active Final Approach Spacing Tool (aFAST) provides speed and heading advisories to help controllers achieve accurate spacing between aircraft on final approach. These advisories will be integrated with those in the existing pFAST to provide a set of comprehensive advisories for controlling arrival traffic from the TRACON boundary to touchdown at complex, high-capacity airports. A research prototype of aFAST, designed for the Dallas-Fort Worth is in an advanced stage of development. The Expedite Departure Path (EDP) and Direct-To tools are designed to help controllers guide departing aircraft out of the TRACON airspace and to climb to cruise altitude along the most efficient routes.

Association of plasma aldosterone with the metabolic syndrome in two German populations.

PubMed

Hannemann, Anke; Meisinger, Christa; Bidlingmaier, Martin; Döring, Angela; Thorand, Barbara; Heier, Margit; Belcredi, Petra; Ladwig, Karl-Heinz; Wallaschofski, Henri; Friedrich, Nele; Schipf, Sabine; Lüdemann, Jan; Rettig, Rainer; Peters, Jörg; Völzke, Henry; Seissler, Jochen; Beuschlein, Felix; Nauck, Matthias; Reincke, Martin

2011-05-01

The aim of this study was to analyze the potential association of the plasma aldosterone concentration (PAC) with the metabolic syndrome (MetS) and its components in two German population-based studies. We selected 2830 and 2901 participants (31-80 years) from the follow-ups of the Study of Health in Pomerania (SHIP)-1 and the Cooperative Health Research in the Region of Augsburg (KORA) F4 respectively. MetS was defined as the presence of at least three out of the following five criteria: waist circumference ≥94 cm (men (m)) and ≥80 cm (women (w)); high-density lipoprotein (HDL) cholesterol <1.0 mmol/l (m) and <1.3 mmol/l (w); blood pressure ≥130/85 mmHg or antihypertensive treatment; non-fasting glucose (SHIP-1) ≥8 mmol/l, fasting glucose (KORA F4) ≥5.55 mmol/l or antidiabetic treatment; non-fasting triglycerides (SHIP-1) ≥2.3 mmol/l, fasting triglycerides (KORA F4) ≥1.7 mmol/l, or lipid-lowering treatment. We calculated logistic regression models by comparing the highest study- and sex-specific PAC quintiles versus all lower quintiles. MetS was common with 48.1% (m) and 34.8% (w) in SHIP-1 and 42.7% (m) and 27.5% (w) in KORA F4. Our logistic regression models revealed associations of PAC with MetS, elevated triglycerides, and decreased HDL cholesterol in SHIP-1 and KORA F4. Our findings add to the increasing evidence supporting a relation between aldosterone and MetS and suggest that aldosterone may be involved in the pathophysiology of MetS and lipid metabolism disorders.

A new Recoil Proton Telescope for energy and fluence measurement of fast neutron fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lebreton, Lena; Bachaalany, Mario; Husson, Daniel

The spectrometer ATHENA (Accurate Telescope for High Energy Neutron metrology Applications), is being developed at the IRSN / LMDN (Institut de Radioprotection et de Surete nucleaire / Laboratoire de Metrologie et de dosimetrie des neutrons) and aims at characterizing energy and fluence of fast neutron fields. The detector is a Recoil Proton Telescope and measures neutron fields in the range of 5 to 20 MeV. This telescope is intended to become a primary standard for both energy and fluence measurements. The neutron detection is achieved by a polyethylene radiator for n-p conversion, three 50{sub m} thick silicon sensors that usemore » CMOS technology for the proton tracking and a 3 mm thick silicon diode to measure the residual proton energy. This first prototype used CMOS sensors called MIMOSTAR, initially developed for heavy ion physics. The use of CMOS sensors and silicon diode increases the intrinsic efficiency of the detector by a factor of ten compared with conventional designs. The first prototype has already been done and was a successful study giving the results it offered in terms of energy and fluence measurements. For mono energetic beams going from 5 to 19 MeV, the telescope offered an energy resolution between 5 and 11% and fluence difference going from 5 to 7% compared to other home standards. A second and final prototype of the detector is being designed. It will hold upgraded CMOS sensors called FastPixN. These CMOS sensors are supposed to run 400 times faster than the older version and therefore give the telescope the ability to support neutron flux in the order of 107 to 108cm{sup 2}:s{sup 1}. The first prototypes results showed that a 50 m pixel size is enough for a precise scattering angle reconstruction. Simulations using MCNPX and GEANT4 are already in place for further improvements. A DeltaE diode will replace the third CMOS sensor and will be installed right before the silicon diode for a better recoil proton selection. The final prototype with its new geometry will increase the telescopes efficiency by a factor of 1.5. It will also cover some of the most important points in metrology; repeatability, reproducibility and sustainability. (authors)« less

Communicating science in public controversies: Strategic considerations of the German climate scientists.

PubMed

Post, Senja

2016-01-01

In public controversies on scientific issues, scientists likely consider the effects of their findings on journalists and on the public debate. A representative survey of 123 German climate scientists (42%) finds that although most climate scientists think that uncertainties about climate change should be made clearer in public they do not actively communicate this to journalists. Moreover, the climate scientists fear that their results could be misinterpreted in public or exploited by interest groups. Asking scientists about their readiness to publish one of two versions of a fictitious research finding shows that their concerns weigh heavier when a result implies that climate change will proceed slowly than when it implies that climate change will proceed fast. © The Author(s) 2014.

Operational test results of the passive final approach spacing tool

DOT National Transportation Integrated Search

1997-06-01

A prototype decision support tool for terminal area air traffic controllers, : referred to as the Final Approach Spacing Tool (FAST), was recently evaluated in : operation with live air traffic at the Dallas/Fort Worth, Texas Airport, : Controllers u...

The software architecture of the camera for the ASTRI SST-2M prototype for the Cherenkov Telescope Array

NASA Astrophysics Data System (ADS)

Sangiorgi, Pierluca; Capalbi, Milvia; Gimenes, Renato; La Rosa, Giovanni; Russo, Francesco; Segreto, Alberto; Sottile, Giuseppe; Catalano, Osvaldo

2016-07-01

The purpose of this contribution is to present the current status of the software architecture of the ASTRI SST-2M Cherenkov Camera. The ASTRI SST-2M telescope is an end-to-end prototype for the Small Size Telescope of the Cherenkov Telescope Array. The ASTRI camera is an innovative instrument based on SiPM detectors and has several internal hardware components. In this contribution we will give a brief description of the hardware components of the camera of the ASTRI SST-2M prototype and of their interconnections. Then we will present the outcome of the software architectural design process that we carried out in order to identify the main structural components of the camera software system and the relationships among them. We will analyze the architectural model that describes how the camera software is organized as a set of communicating blocks. Finally, we will show where these blocks are deployed in the hardware components and how they interact. We will describe in some detail, the physical communication ports and external ancillary devices management, the high precision time-tag management, the fast data collection and the fast data exchange between different camera subsystems, and the interfacing with the external systems.

Prototype Development of the GMT Fast Steering Mirror

NASA Astrophysics Data System (ADS)

Kim, Young-Soo; Koh, J.; Jung, H.; Jung, H.; Cho, M. K.; Park, W.; Yang, H.; Kim, H.; Lee, K.; Ahn, H.; Park, B.

2014-01-01

A Fast Steering Mirror (FSM) is going to be provided as the secondary of the Giant Magellan Telescope (GMT) for the first light observations. FSM is 3.2 m in diameter and the focal ratio is 0.65. It is composed of seven circular segments which match with the primary mirror segments. Each segment contains a light-weighted mirror whose diameter is 1.1 m, and each mirror is activated by three tip-tilt actuators which compensate image degradations caused by winds and structure jitter. An FSM prototype (FSMP) has been developed to achieve the key technologies, fabrication of highly aspheric off-axis mirror and precise tip-tilt actuation. It consists of a full-size off-axis mirror segment and a tip-tilt test-bed. The development has been conducted by Korea Astronomy and Space Science Institute together with four other institutions in Korea and USA. The mirror was light-weighted by digging about a hundred holes at the backside, and the front surface has been polished. The result of computer generated hologram measurements showed the surface error of 11.7 nm rms. The tip-tilt test-bed has been manufactured and assembled. Tip-tilt range and resolution tests complied the requirements, and the attenuation test results also satisfied the performance requirements. In this paper, we present the successful developments of the prototype.

Assessment of cardiovascular disease risk in patients with schizophrenia spectrum disorders in German psychiatric hospitals: results of the pharmacoepidemiologic CATS study.

PubMed

Deuschle, M; Paul, F; Brosz, M; Bergemann, N; Franz, M; Kammerer-Ciernioch, J; Lautenschlager, M; Lederbogen, F; Roesch-Ely, D; Weisbrod, M; Kahl, K G; Reichmann, J; Gross, J; Umbreit, J

2013-08-01

Patients with severe mental illness are at high risk for metabolic and cardiac disorders. Thus, monitoring of cardiovascular risks is imperative and schedules for screening for lipids, glucose, body mass index (BMI), waist-hip ratio and blood pressure have been developed. We intended to analyze screening for metabolic disorders in German patients with schizophrenia spectrum disorders in routine psychiatric care. We included 674 patients with any F2 diagnosis in out- and inpatient settings and analyzed metabolic screening procedures as practiced under conditions of usual care. Except BMI (54 %), all other values were documented only in a minority of patients: waist circumference (23 %), cholesterol (28 %), fasting glucose (19 %), triglycerides (25 %) and blood pressure (37 %). We found evidence for less than perfect quality of blood pressure measures. The group of patients who met the individual metabolic syndrome ATP III criteria was comparable to the US CATIE trial. We conclude that frequency and quality of metabolic monitoring in German in- and outpatients settings are not in accordance with the respective recommendations. Similar to previous reports we found evidence for a high prevalence of metabolic disturbances in German patients with schizophrenia spectrum disorders.

Development of prototype induced-fission-based Pu accountancy instrument for safeguards applications.

PubMed

Seo, Hee; Lee, Seung Kyu; An, Su Jung; Park, Se-Hwan; Ku, Jeong-Hoe; Menlove, Howard O; Rael, Carlos D; LaFleur, Adrienne M; Browne, Michael C

2016-09-01

Prototype safeguards instrument for nuclear material accountancy (NMA) of uranium/transuranic (U/TRU) products that could be produced in a future advanced PWR fuel processing facility has been developed and characterized. This is a new, hybrid neutron measurement system based on fast neutron energy multiplication (FNEM) and passive neutron albedo reactivity (PNAR) methods. The FNEM method is sensitive to the induced fission rate by fast neutrons, while the PNAR method is sensitive to the induced fission rate by thermal neutrons in the sample to be measured. The induced fission rate is proportional to the total amount of fissile material, especially plutonium (Pu), in the U/TRU product; hence, the Pu amount can be calibrated as a function of the induced fission rate, which can be measured using either the FNEM or PNAR method. In the present study, the prototype system was built using six (3)He tubes, and its performance was evaluated for various detector parameters including high-voltage (HV) plateau, efficiency profiles, dead time, and stability. The system's capability to measure the difference in the average neutron energy for the FNEM signature also was evaluated, using AmLi, PuBe, (252)Cf, as well as four Pu-oxide sources each with a different impurity (Al, F, Mg, and B) and producing (α,n) neutrons with different average energies. Future work will measure the hybrid signature (i.e., FNEM×PNAR) for a Pu source with an external interrogating neutron source after enlarging the cavity size of the prototype system to accommodate a large-size Pu source (~600g Pu). Copyright © 2016 Elsevier Ltd. All rights reserved.

Merlin - Massively parallel heterogeneous computing

NASA Technical Reports Server (NTRS)

Wittie, Larry; Maples, Creve

1989-01-01

Hardware and software for Merlin, a new kind of massively parallel computing system, are described. Eight computers are linked as a 300-MIPS prototype to develop system software for a larger Merlin network with 16 to 64 nodes, totaling 600 to 3000 MIPS. These working prototypes help refine a mapped reflective memory technique that offers a new, very general way of linking many types of computer to form supercomputers. Processors share data selectively and rapidly on a word-by-word basis. Fast firmware virtual circuits are reconfigured to match topological needs of individual application programs. Merlin's low-latency memory-sharing interfaces solve many problems in the design of high-performance computing systems. The Merlin prototypes are intended to run parallel programs for scientific applications and to determine hardware and software needs for a future Teraflops Merlin network.

Scintillating fibres coupled to silicon photomultiplier prototypes for fast beam monitoring and thin timing detectors

NASA Astrophysics Data System (ADS)

Papa, A.; Kettle, P.-R.; Ripiccini, E.; Rutar, G.

2016-07-01

Several scintillating fibre prototypes (single- and double-layers) made of 250 μm multi-clad square fibres coupled to silicon photomultiplier have been studied using electrons, positrons and muons at different energies. Current measurements show promising results: already for a single fibre layer and minimum ionizing particles we obtain a detection efficiency ≥ 95 % (mean collected light/fibre ≈ 8 phe), a timing resolution of 550 ps/fibre and a foreseen spatial resolution < 100 μm, based on the achieved negligible optical cross-talk between fibres (< 1 %). We will also discuss the performances of a double-layer staggered prototype configuration, for which a full detection efficiency (≥ 99 %) has been measured together with a timing resolution of ≈ 400 ps for double hit events.

High-temperature ceramics for automobile gas turbines

NASA Technical Reports Server (NTRS)

Walzer, P.

1978-01-01

The employment of the high operational temperatures makes it necessary to use, for the construction of the turbines, ceramic materials such as silicon nitride or silicon carbide. Investigations concerning the development of turbine components made of such materials are conducted by a German automobile manufacturer and the ceramics industry. The current status of these investigations is reviewed. Flame tubes and guide-vane rings have successfully passed tests lasting 20 hours. Prototype turbine wheels have withstood the effects of peripheral speeds of 450 m/s. They also showed resistance to thermal shocks which were as high as 6-0 K/s.

Rapidly Characterizing the Fast Dynamics of RNA Genetic Circuitry with Cell-Free Transcription–Translation (TX-TL) Systems

PubMed Central

2014-01-01

RNA regulators are emerging as powerful tools to engineer synthetic genetic networks or rewire existing ones. A potential strength of RNA networks is that they may be able to propagate signals on time scales that are set by the fast degradation rates of RNAs. However, a current bottleneck to verifying this potential is the slow design-build-test cycle of evaluating these networks in vivo. Here, we adapt an Escherichia coli-based cell-free transcription-translation (TX-TL) system for rapidly prototyping RNA networks. We used this system to measure the response time of an RNA transcription cascade to be approximately five minutes per step of the cascade. We also show that this response time can be adjusted with temperature and regulator threshold tuning. Finally, we use TX-TL to prototype a new RNA network, an RNA single input module, and show that this network temporally stages the expression of two genes in vivo. PMID:24621257

Helium Leak Detection of Vessels in Fuel Transfer Cell (FTC) of Prototype Fast Breeder Reactor (PFBR)

NASA Astrophysics Data System (ADS)

Dutta, N. G.

2012-11-01

Bharatiya Nabhikiya Vidyut Nigam (BHAVINI) is engaged in construction of 500MW Prototype Fast Breeder Reactor (PFBR) at Kalpak am, Chennai. In this very important and prestigious national programme Special Product Division (SPD) of M/s Kay Bouvet Engg.pvt. ltd. (M/s KBEPL) Satara is contributing in a major way by supplying many important sub-assemblies like- Under Water trolley (UWT), Airlocks (PAL, EAL) Container and Storage Rack (CSR) Vessels in Fuel Transfer Cell (FTC) etc for PFBR. SPD of KBEPL caters to the requirements of Government departments like - Department of Atomic Energy (DAE), BARC, Defense, and Government undertakings like NPCIL, BHAVINI, BHEL etc. and other precision Heavy Engg. Industries. SPD is equipped with large size Horizontal Boring Machines, Vertical Boring Machines, Planno milling, Vertical Turret Lathe (VTL) & Radial drilling Machine, different types of welding machines etc. PFBR is 500 MWE sodium cooled pool type reactor in which energy is produced by fissions of mixed oxides of Uranium and Plutonium pellets by fast neutrons and it also breeds uranium by conversion of thorium, put along with fuel rod in the reactor. In the long run, the breeder reactor produces more fuel then it consumes. India has taken the lead to go ahead with Fast Breeder Reactor Programme to produce electricity primarily because India has large reserve of Thorium. To use Thorium as further fuel in future, thorium has to be converted in Uranium by PFBR Technology.

3D printed microfluidic mixer for point-of-care diagnosis of anemia.

PubMed

Plevniak, Kimberly; Campbell, Matthew; Mei He

2016-08-01

3D printing has been an emerging fabrication tool in prototyping and manufacturing. We demonstrated a 3D microfluidic simulation guided computer design and 3D printer prototyping for quick turnaround development of microfluidic 3D mixers, which allows fast self-mixing of reagents with blood through capillary force. Combined with smartphone, the point-of-care diagnosis of anemia from finger-prick blood has been successfully implemented and showed consistent results with clinical measurements. Capable of 3D fabrication flexibility and smartphone compatibility, this work presents a novel diagnostic strategy for advancing personalized medicine and mobile healthcare.

HAI: A novel airborne multi-channel hygrometer for fast multi-phase H2O quantification: Performance of the HAI instrument during the first flights on the German HALO aircraft

NASA Astrophysics Data System (ADS)

Buchholz, B.; Ebert, V.; Kraemer, M.; Afchine, A.

2014-12-01

Common gas phase H2O measurements on fast airborne platforms e.g. using backward facing or "Rosemount"-inlets can lead to a high risk of ice and droplets contamination. In addition, currently no single hygrometer exists that allows a simultaneous, high-speed measurement of all phases (gas, liquid, ice) with the same detection principle. In the rare occasions multi-phase measurements are realized, gas-and condensed-phase observations rely on different methods, instruments and calibration strategies so that precision and accuracy levels are quite difficult to quantify. This is effectively avoided by the novel TDLAS instrument, HAI, Hygrometer for Atmospheric Investigation, which allows a simultaneous, high speed, multi-phase detection without any sensor calibration in a unique "2+2" channel concept. Hai combines two independent wavelength channels, at 1.4 µm and at 2.6 µm, for a wide dynamic range from 1 to 30 000 ppmv, with a simultaneous closed path (extractive) and open path detection. Thus, "Total", i.e. gas-phase plus condensed-phase water is measured by sampling via a forward facing inlet into "closed-path" extractive cells. A selective, sampling-free, high speed gas phase detection is realized via a dual-wavelength "open-path" cell placed outside of the aircraft fuselage. All channels can be sampled with 120 Hz (measurement cycle time Dt=1.6 ms) allowing an unprecedented spatial resolution of 30 cm at 900 km/h. The evaluation of the individual multi-channel raw-data is done post flight, without any channel interdependencies, in calibration-free mode, thus allowing fast, accurate and precise multi-phase water detection in flight. The performance could be shown in more than 200 net flights hours in three scientific flight campaigns (TACTS, ESMVal, ML-CIRRUS) on the new German HALO aircraft. In addition the level of the accuracy of the calibration free evaluation was evaluated at the German national primary water vapor standard.

Clustering of unhealthy food around German schools and its influence on dietary behavior in school children: a pilot study

PubMed Central

2013-01-01

Background The availability of fast foods, sweets, and other snacks in the living environment of children is assumed to contribute to an obesogenic environment. In particular, it is hypothesized that food retailers are spatially clustered around schools and that a higher availability of unhealthy foods leads to its higher consumption in children. Studies that support these relationships have primarily been conducted in the U.S. or Australia, but rarely in European communities. We used data of FFQ and 24-HDR of the IDEFICS study, as well as geographical data from one German study region to investigate (1) the clustering of food outlets around schools and (2) the influence of junk food availability on the food intake in school children. Methods We geocoded food outlets offering junk food (e.g. supermarkets, kiosks, and fast food restaurants). Spatial cluster analysis of food retailers around child-serving institutions was conducted using an inhomogeneous K-function to calculate global 95% confidence envelopes. Furthermore, a food retail index was implemented considering the kernel density of junk food supplies per service area, adjusted for residential density. We linked the food retail index to FFQ and 24-HDR data of 384 6- to 9-year-old school children in the study region and investigated the impact of the index on food intake, using multilevel regression models adjusted for sex, age, BMI, parent’s education and income, as well as adjusting for over- and underreporting of food intake. Results Comparing the 95% confidence envelopes to the observed K-function, we showed that food stores and fast food restaurants do not significantly cluster around schools. Apart from this result, the food retail index showed no effect on BMI (β=0.01,p=0.11) or food intake variables assessed by FFQ and 24-HDR. Conclusion In the built environment of the German study region, clustering of food retailers does not depend on the location of schools. Additionally, the results suggest that the consumption of junk food in young children is not influenced by spatial availability of unhealthy food. However, investigations should be replicated in other European communities to increase environmental variability. PMID:23714200

Clustering of unhealthy food around German schools and its influence on dietary behavior in school children: a pilot study.

PubMed

Buck, Christoph; Börnhorst, Claudia; Pohlabeln, Hermann; Huybrechts, Inge; Pala, Valeria; Reisch, Lucia; Pigeot, Iris

2013-05-24

The availability of fast foods, sweets, and other snacks in the living environment of children is assumed to contribute to an obesogenic environment. In particular, it is hypothesized that food retailers are spatially clustered around schools and that a higher availability of unhealthy foods leads to its higher consumption in children. Studies that support these relationships have primarily been conducted in the U.S. or Australia, but rarely in European communities. We used data of FFQ and 24-HDR of the IDEFICS study, as well as geographical data from one German study region to investigate (1) the clustering of food outlets around schools and (2) the influence of junk food availability on the food intake in school children. We geocoded food outlets offering junk food (e.g. supermarkets, kiosks, and fast food restaurants). Spatial cluster analysis of food retailers around child-serving institutions was conducted using an inhomogeneous K-function to calculate global 95% confidence envelopes. Furthermore, a food retail index was implemented considering the kernel density of junk food supplies per service area, adjusted for residential density. We linked the food retail index to FFQ and 24-HDR data of 384 6- to 9-year-old school children in the study region and investigated the impact of the index on food intake, using multilevel regression models adjusted for sex, age, BMI, parent's education and income, as well as adjusting for over- and underreporting of food intake. Comparing the 95% confidence envelopes to the observed K-function, we showed that food stores and fast food restaurants do not significantly cluster around schools. Apart from this result, the food retail index showed no effect on BMI (β=0.01,p=0.11) or food intake variables assessed by FFQ and 24-HDR. In the built environment of the German study region, clustering of food retailers does not depend on the location of schools. Additionally, the results suggest that the consumption of junk food in young children is not influenced by spatial availability of unhealthy food. However, investigations should be replicated in other European communities to increase environmental variability.

A new fast detection system at the KWS-2 high-intensity SANS diffractometer of the JCNS at MLZ - prototype test

NASA Astrophysics Data System (ADS)

Radulescu, A.; Arend, N.; Drochner, M.; Ioffe, A.; Kemmerling, G.; Ossovyi, V.; Staringer, S.; Vehres, G.; McKinny, K.; Olechnowicz, B.; Yen, D.

2016-09-01

A new detection system based on an array of 3He tubes and innovative fast detection electronics was designed and produced by GE Reuter Stokes for the high-intensity small-angle neutron scattering diffractometer KWS-2, operated by the Jülich Centre for Neutron Science (JCNS) at the Heinz Meier-Leibnitz Zentrum (MLZ). The new detector consists of a panel array of 144 3He tubes and a new fast read-out electronics. The electronics is mounted in a closed case in the backside of the 3He tubes panel array and will operate at ambient atmosphere under cooling air stream. The new detection system is composed of eighteen 8-pack modules of 3He-tubes that work independently of one another (each unit has its own processor and electronics). Knowing beforehand the performance of one detector unit and of one single tube detector is prerequisite for tuning and maximizing the performance of the complete detection system. In this paper we present the results of the tests of the prototyped 8-pack of 3He-tubes and corresponding electronics, which have been carried out at the JCNS instruments KWS-2 (in high flux conditions) and TREFF.

Design of an efficient framework for fast prototyping of customized human-computer interfaces and virtual environments for rehabilitation.

PubMed

Avola, Danilo; Spezialetti, Matteo; Placidi, Giuseppe

2013-06-01

Rehabilitation is often required after stroke, surgery, or degenerative diseases. It has to be specific for each patient and can be easily calibrated if assisted by human-computer interfaces and virtual reality. Recognition and tracking of different human body landmarks represent the basic features for the design of the next generation of human-computer interfaces. The most advanced systems for capturing human gestures are focused on vision-based techniques which, on the one hand, may require compromises from real-time and spatial precision and, on the other hand, ensure natural interaction experience. The integration of vision-based interfaces with thematic virtual environments encourages the development of novel applications and services regarding rehabilitation activities. The algorithmic processes involved during gesture recognition activity, as well as the characteristics of the virtual environments, can be developed with different levels of accuracy. This paper describes the architectural aspects of a framework supporting real-time vision-based gesture recognition and virtual environments for fast prototyping of customized exercises for rehabilitation purposes. The goal is to provide the therapist with a tool for fast implementation and modification of specific rehabilitation exercises for specific patients, during functional recovery. Pilot examples of designed applications and preliminary system evaluation are reported and discussed. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Chalcogenide molded freeform optics for mid-infrared lasers

NASA Astrophysics Data System (ADS)

Chenard, Francois; Alvarez, Oseas; Yi, Allen

2017-05-01

High-precision chalcogenide molded micro-lenses were produced to collimate mid-infrared Quantum Cascade Lasers (QCLs). Molded cylindrical micro-lens prototypes with aspheric contour (acylindrical), high numerical aperture (NA 0.8) and small focal length (f<2 mm) were fabricated to collimate the QCL fast-axis beam. Another innovative freeform micro-lens has an input acylindrical surface to collimate the fast axis and an orthogonal output acylindrical surface to collimate the slow axis. The thickness of the freeform lens is such that the output fast- and slow-axis beams are circular. This paper presents results on the chalcogenide molded freeform micro-lens designed to collimate and circularize QCL at 4.6 microns.

A simple method to prevent hard X-ray-induced preheating effects inside the cone tip in indirect-drive fast ignition implosions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Dongxiao; Shan, Lianqiang; Zhou, Weimin

During fast-ignition implosions, preheating of inside the cone tip caused by hard X-rays can strongly affect the generation and transport of hot electrons in the cone. Although indirect-drive implosions have a higher implosion symmetry, they cause stronger preheating effects than direct-drive implosions. To control the preheating of the cone tip, we propose the use of indirect-drive fast-ignition targets with thicker tips. Experiments carried out at the ShenGuang-III prototype laser facility confirmed that thicker tips are effective for controlling preheating. Moreover, these results were consistent with those of 1D radiation hydrodynamic simulations.

Aerosol-jet printing of nanowire networks of zinc octaethylporphyrin and its application in flexible photodetectors.

PubMed

Wang, Feng-Xia; Lin, Jian; Gu, Wei-Bing; Liu, Yong-Qiang; Wu, Hao-Di; Pan, Ge-Bo

2013-03-25

Nanowire networks of zinc octaethylporphyrin (ZnOEP) were printed using an aerosol-jet printer on a poly(ethylene terephthalate) (PET) flexible substrate. The prototype photodetector based on the as-printed network exhibited high photosensitivity, fast photoresponse, and excellent mechanical stability.

[Study of efficiancy of teleconsultation: the Telepathology Consultation Service of the Professional Assoziation of German Pathologists for the screening program of breast carcinoma].

PubMed

Schrader, T; Hufnagl, P; Schlake, W; Dietel, M

2005-01-01

In the autumn a German screening program was started for detecting breast cancer in the population of women fifty and above. For the first time in this program, quality assurance rules were established: All statements of the radiologists and pathologists have to be confirmed by a second opinion. This improvement in quality is combined with a delay in time and additional expence. A new Telepathology Consultation Service was developed based on the experiences of the Telepathology Consultation Center of the UICC to speed up the second opinion process. The complete web-based service is operated under MS Windows 2003 Server, as web server the Internet Information Server, and the SQL-Server (both Microsoft) as the database. The websites, forms and control mechanism have been coded in by ASP scripts and JavaScript. A study to evaluate the effectiveness of telepathological consultation in comparison to conventional consultation has been carried out. Pathologists of the Professional Association of German Pathologists took part as well as requesting pathologists and as consultants for other participants. The quality of telepathological diagnosis was comparable to the conventional diagnosis. Telepathology allows a faster respond of 1 to 2 day (conventional postal delay). The time to prepare a telepathology request is about twice as conventional. This ratio may be inverted by an interface between the Pathology Information System and the Telepathology Server and the use of virtual microscopy. The Telepathology Consultation Service of the Professional Association of German Pathologists is a fast and effective German-language, internet-based service for obtaining a second opinion.

Towards real-time VMAT verification using a prototype, high-speed CMOS active pixel sensor.

PubMed

Zin, Hafiz M; Harris, Emma J; Osmond, John P F; Allinson, Nigel M; Evans, Philip M

2013-05-21

This work investigates the feasibility of using a prototype complementary metal oxide semiconductor active pixel sensor (CMOS APS) for real-time verification of volumetric modulated arc therapy (VMAT) treatment. The prototype CMOS APS used region of interest read out on the chip to allow fast imaging of up to 403.6 frames per second (f/s). The sensor was made larger (5.4 cm × 5.4 cm) using recent advances in photolithographic technique but retains fast imaging speed with the sensor's regional read out. There is a paradigm shift in radiotherapy treatment verification with the advent of advanced treatment techniques such as VMAT. This work has demonstrated that the APS can track multi leaf collimator (MLC) leaves moving at 18 mm s(-1) with an automatic edge tracking algorithm at accuracy better than 1.0 mm even at the fastest imaging speed. Evaluation of the measured fluence distribution for an example VMAT delivery sampled at 50.4 f/s was shown to agree well with the planned fluence distribution, with an average gamma pass rate of 96% at 3%/3 mm. The MLC leaves motion and linac pulse rate variation delivered throughout the VMAT treatment can also be measured. The results demonstrate the potential of CMOS APS technology as a real-time radiotherapy dosimeter for delivery of complex treatments such as VMAT.

Integration of homeostatic signaling and food reward processing in the human brain.

PubMed

Simon, Joe J; Wetzel, Anne; Sinno, Maria Hamze; Skunde, Mandy; Bendszus, Martin; Preissl, Hubert; Enck, Paul; Herzog, Wolfgang; Friederich, Hans-Christoph

2017-08-03

Food intake is guided by homeostatic needs and by the reward value of food, yet the exact relation between the two remains unclear. The aim of this study was to investigate the influence of different metabolic states and hormonal satiety signaling on responses in neural reward networks. Twenty-three healthy participants underwent functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food- or monetary-related reward. Every participant was scanned twice in a counterbalanced fashion, both during a fasted state (after 24 hours fasting) and satiety. A functional connectivity analysis was performed to investigate the influence of satiety signaling on activation in neural reward networks. Blood samples were collected to assess hormonal satiety signaling. Fasting was associated with sensitization of the striatal reward system to the anticipation of food reward irrespective of reward magnitude. Furthermore, during satiety, individual ghrelin levels were associated with increased neural processing during the expectation of food-related reward. Our findings show that physiological hunger stimulates food consumption by specifically increasing neural processing during the expectation (i.e., incentive salience) but not the receipt of food-related reward. In addition, these findings suggest that ghrelin signaling influences hedonic-driven food intake by increasing neural reactivity during the expectation of food-related reward. These results provide insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward. ClinicalTrials.gov NCT03081585. This work was supported by the German Competence Network on Obesity, which is funded by the German Federal Ministry of Education and Research (FKZ 01GI1122E).

On-line access to remote sensing data with the satellite-data information system (ISIS)

NASA Astrophysics Data System (ADS)

Strunz, G.; Lotz-Iwen, H.-J.

1994-08-01

The German Remote Sensing Data Center (DFD) is developing the satellite-data information system ISIS as central interface for users to access Earth observation data. ISIS has been designed to support international scientific research as well as operational applications by offering online database access via public networks, and is integrated in the international activities dedicated to catalogue and archive interoperability. A prototype of ISIS is already in use within the German Processing and Archiving Facility for ERS-1 for the storage and retrieval of digital SAR quicklook products and for the Radarmap of Germany. An operational status of the system is envisaged for the launch of ERS-2. The paper in hand describes the underlying concepts of ISIS and the recent state of realization. It explains the overall structure of the system and the functionality of each of its components. Emphasis is put on the description of the advisory system, the catalogue retrieval, and the online access and transfer of image data. Finally, the integration into a future global environmental data network is outlined.

Optimization and Characterization of a Novel Self Powered Solid State Neutron Detector

NASA Astrophysics Data System (ADS)

Clinton, Justin

There is a strong interest in detecting both the diversion of special nuclear material (SNM) from legitimate, peaceful purposes and the transport of illicit SNM across domestic and international borders and ports. A simple solid-state detector employs a planar solar-cell type p-n junction and a thin conversion layer that converts incident neutrons into detectable charged particles, such as protons, alpha-particles, and heavier ions. Although simple planar devices can act as highly portable, low cost detectors, they have historically been limited to relatively low detection efficiencies; ˜10% and ˜0.2% for thermal and fast detectors, respectively. To increase intrinsic detection efficiency, the incorporation of 3D microstructures into p-i-n silicon devices was proposed. In this research, a combination of existing and new types of detector microstructures were investigated; Monte Carlo models, based on analytical calculations, were constructed and characterized using the GEANT4 simulation toolkit. The simulation output revealed that an array of etched hexagonal holes arranged in a honeycomb pattern and filled with either enriched (99% 10B) boron or parylene resulted in the highest intrinsic detection efficiencies of 48% and 0.88% for thermal and fast neutrons, respectively. The optimal parameters corresponding to each model were utilized as the basis for the fabrication of several prototype detectors. A calibrated 252Cf spontaneous fission source was utilized to generate fast neutrons, while thermal neutrons were created by placing the 252Cf in an HDPE housing designed and optimized using the MCNP simulation software. Upon construction, thermal neutron calibration was performed via activation analysis of gold foils and measurements from a 6Li loaded glass scintillator. Experimental testing of the prototype detectors resulted in maximum intrinsic efficiencies of 4.5 and 0.12% for the thermal and fast devices, respectively. The prototype thermal device was filled with natural (19% 10B) boron; scaling the response to 99% 10B enriched boron resulted in an intrinsic efficiency of 22.5%, one of the highest results in the literature. A comparison of simulated and experimental detector responses demonstrated a high degree of correlation, validating the conceptual models.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Venkataraman, M.; Natarajan, R.; Raj, Baldev

The reprocessing of spent fuel from Fast Breeder Test Reactor (FBTR) has been successfully demonstrated in the pilot plant, CORAL (COmpact Reprocessing facility for Advanced fuels in Lead shielded cell). Since commissioning in 2003, spent mixed carbide fuel from FBTR of different burnups and varying cooling period, have been reprocessed in this facility. Reprocessing of the spent fuel with a maximum burnup of 100 GWd/t has been successfully carried out so far. The feed backs from these campaigns with progressively increasing specific activities, have been useful in establishing a viable process flowsheet for reprocessing the Prototype Fast Breeder Reactor (PFBR)more » spent fuel. Also, the design of various equipments and processes for the future plants, which are either under design for construction, namely, the Demonstration Fast Reactor Fuel Reprocessing Plant (DFRP) and the Fast reactor fuel Reprocessing Plant (FRP) could be finalized. (authors)« less

Development of a neutronics calculation method for designing commercial type Japanese sodium-cooled fast reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takeda, T.; Shimazu, Y.; Hibi, K.

2012-07-01

Under the R and D project to improve the modeling accuracy for the design of fast breeder reactors the authors are developing a neutronics calculation method for designing a large commercial type sodium- cooled fast reactor. The calculation method is established by taking into account the special features of the reactor such as the use of annular fuel pellet, inner duct tube in large fuel assemblies, large core. The Verification and Validation, and Uncertainty Qualification (V and V and UQ) of the calculation method is being performed by using measured data from the prototype FBR Monju. The results of thismore » project will be used in the design and analysis of the commercial type demonstration FBR, known as the Japanese Sodium fast Reactor (JSFR). (authors)« less

Automated analysis of SKS splitting to infer upper mantle anisotropy beneath Germany using more than 20 yr of GRSN and GRF data

NASA Astrophysics Data System (ADS)

Walther, M.; Plenefisch, T.; Rümpker, G.

2014-02-01

Upper mantle anisotropy beneath Germany is investigated through the measurements and analysis of shear-wave splitting using SKS phases. We analysed teleseismic events recorded by 24 broadband stations of the German Regional Seismic Network (GRSN) and three broadband stations of the Gräfenberg-Array (GRF). These permanent German networks cover an area extending from the Alps in the south up to the Northern German basin towards north. In comparison to several former studies that are based either on short observation periods or that are restricted to limited areas of Germany, we resort to 22 yr of the GRSN (1991-2012) and 34 yr of GRF data archive (1979-2012). Due to the huge amount of data, we applied a fully automatic procedure to determine SKS splitting parameters from archived recordings and also applied strong quality constraints to obtain reliable solutions. From our analysis, two main features are obvious: For the stations in the middle and southern part of Germany we found homogeneous E-W to ENE-WSW fast-axis directions. In contrast, stations in NE-Germany exhibit a NW-SE oriented fast axis. Both findings can be correlated to major tectonic features in Central Europe. The E-W to ENE-WSW orientations in the middle and southern part of Germany are nearly parallel to the strike of the Variscan mountain belts, whereas the NW-SE direction in NE-Germany corresponds to the orientation of the nearby Tornquist-Teisseyre suture zone. For the southern part of Germany, there are indications for an alignment of the fast axis parallel to the curvature of the nearby Alps. Apart from the more large-scale features there are two stations (BFO and CLZ) which seem to have an imprint related to the regional geodynamic setting, namely the rifting in the Southern Rhine Graben and the formation of the Harz Mountains, respectively. We conclude that the observed regional variations of splitting parameter over Germany advocate for a mostly lithospheric route of the anisotropy. Furthermore, variations of the splitting parameters with respect to the azimuths of the incoming waves, as observed at some stations, point to vertical varying anisotropy. For some stations (BFO, RUE) the inversions for two anisotropic layers revealed directions of the fast axes that are similar to the strike directions of the surrounding tectonic units. For other stations, the confidence regions are too large for a tectonic interpretation.

Addendum to `numerical modeling of an enhanced very early time electromagnetic (VETEM) prototype system'

USGS Publications Warehouse

Cui, T.J.; Chew, W.C.; Aydiner, A.A.; Wright, D.L.; Smith, D.V.; Abraham, J.D.

2000-01-01

Two numerical models to simulate an enhanced very early time electromagnetic (VETEM) prototype system that is used for buried-object detection and environmental problems are presented. In the first model, the transmitting and receiving loop antennas accurately analyzed using the method of moments (MoM), and then conjugate gradient (CG) methods with the fast Fourier transform (FFT) are utilized to investigate the scattering from buried conducting plates. In the second model, two magnetic dipoles are used to replace the transmitter and receiver. Both the theory and formulation are correct and the simulation results for the primary magnetic field and the reflected magnetic field are accurate.

Ultrafast holographic technique for 3D in situ documentation of cultural heritage

NASA Astrophysics Data System (ADS)

Frey, Susanne; Bongartz, Jens; Giel, Dominik M.; Thelen, Andrea; Hering, Peter

2003-10-01

A novel 3d reconstruction method for medical application has been applied for the examination and documentation of a 2000-year-old bog body. An ultra-fast pulsed holographic camera has been modified to allow imaging of the bog body from different views. Full-scale daylight copies of the master holograms give a detailed impressive three-dimensional view of the mummy and can be exhibited instead of the object. In combination with a rapid prototyping model (built by the Rapid Prototyping group of the Stiftung caesar, Bonn, Germany) derived from computer tomography (CT) data our results are an ideal basis for a future facial reconstruction.

A fast and flexible method for manufacturing 3D molded interconnect devices by the use of a rapid prototyping technology

NASA Astrophysics Data System (ADS)

Amend, P.; Pscherer, C.; Rechtenwald, T.; Frick, T.; Schmidt, M.

This paper presents experimental results of manufacturing MID-prototypes by means of SLS, laser structuring and metallization. Therefore common SLS powder (PA12) doped with laser structuring additives is used. First of all the influence of the additives on the characteristic temperatures of melting and crystallization is analyzed by means of DSC. Afterwards the sintering process is carried out and optimized by experiments. Finally the generated components are qualified regarding their density, mechanical properties and surface roughness. Especially the surface quality is important for the metallization process. Therefore surface finishing techniques are investigated.

Characterization of hydrogel printer for direct cell-laden scaffolds

NASA Astrophysics Data System (ADS)

Whulanza, Yudan; Arsyan, Rendria; Saragih, Agung Shamsuddin

2018-02-01

The additive manufacturing technology has been massively developed since the last decade. The technology was previously known as rapid prototyping techniques that aimed to produce a prototyping product in fast and economical way. Currently, this technique is also applied to fabricate microstructure utilized in tissue engineering technology. Here, we introduce a 3D printer which using hydrogel gelatin to realize cell laden scaffold with dimension around 50-100 µm. However, in order to fabricate such a precise dimension, an optimum working parameters are required to control the physical properties of gelatin. At the end of our study, we formulated the best parameters to perform the product as we desired.

Status of the EDDA experiment at COSY

NASA Astrophysics Data System (ADS)

Scobel, W.; EDDA Collaboration; Bisplinghoff, J.; Bollmann, R.; Cloth, P.; Dohrmann, F.; Dorner, G.; Drüke, V.; Ernst, J.; Eversheim, P. D.; Filges, D.; Gasthuber, M.; Gebel, R.; Groß, A.; Groß-Hardt, R.; Hinterberger, F.; Jahn, R.; Lahr, U.; Langkau, R.; Lippert, G.; Mayer-Kuckuk, T.; Maschuw, R.; Mertler, G.; Metsch, B.; Mosel, F.; Paetz gen Schieck, H.; Petry, H. R.; Prasuhn, D.; von Przewoski, B.; Rohdjeß, H.; Rosendaal, D.; von Rossen, P.; Scheid, H.; Schirm, N.; Schwandt, F.; Stein, H.; Theis, D.; Weber, J.; Wiedmann, W.; Woller, K.; Ziegler, R.

1993-07-01

The EDDA experiment is designed to study p + p excitation functions with high energy resolution and narrow step size in the kinetic energy range from 250 MeV to 2500 MeV at the Cooler Synchrotron COSY. Measurements during the accelertion phase in conjunction with internal targets will allow to achieve a fast and precise energy variation. Prototypes of the detector elements and the fiber target have been extensively tested with proton and electron beams; the detector performance and trigger efficiency have been studied in Monte Carlo simulations. In this contribution, results concerning detector design, prototype studies, Monte Carlo simulations and the anticipated detector resolutions will be reported.

Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure.

PubMed

Sonntag, Frank; Schilling, Niels; Mader, Katja; Gruchow, Mathias; Klotzbach, Udo; Lindner, Gerd; Horland, Reyk; Wagner, Ilka; Lauster, Roland; Howitz, Steffen; Hoffmann, Silke; Marx, Uwe

2010-07-01

Dynamic miniaturized human multi-micro-organ bioreactor systems are envisaged as a possible solution for the embarrassing gap of predictive substance testing prior to human exposure. A rational approach was applied to simulate and design dynamic long-term cultures of the smallest possible functional human organ units, human "micro-organoids", on a chip the shape of a microscope slide. Each chip contains six identical dynamic micro-bioreactors with three different micro-organoid culture segments each, a feed supply and waste reservoirs. A liver, a brain cortex and a bone marrow micro-organoid segment were designed into each bioreactor. This design was translated into a multi-layer chip prototype and a routine manufacturing procedure was established. The first series of microscopable, chemically resistant and sterilizable chip prototypes was tested for matrix compatibility and primary cell culture suitability. Sterility and long-term human cell survival could be shown. Optimizing the applied design approach and prototyping tools resulted in a time period of only 3 months for a single design and prototyping cycle. This rapid prototyping scheme now allows for fast adjustment or redesign of inaccurate architectures. The designed chip platform is thus ready to be evaluated for the establishment and maintenance of the human liver, brain cortex and bone marrow micro-organoids in a systemic microenvironment. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Design of rapid prototype of UAV line-of-sight stabilized control system

NASA Astrophysics Data System (ADS)

Huang, Gang; Zhao, Liting; Li, Yinlong; Yu, Fei; Lin, Zhe

2018-01-01

The line-of-sight (LOS) stable platform is the most important technology of UAV (unmanned aerial vehicle), which can reduce the effect to imaging quality from vibration and maneuvering of the aircraft. According to the requirement of LOS stability system (inertial and optical-mechanical combined method) and UAV's structure, a rapid prototype is designed using based on industrial computer using Peripheral Component Interconnect (PCI) and Windows RTX to exchange information. The paper shows the control structure, and circuit system including the inertial stability control circuit with gyro and voice coil motor driven circuit, the optical-mechanical stability control circuit with fast-steering-mirror (FSM) driven circuit and image-deviation-obtained system, outer frame rotary follower, and information-exchange system on PC. Test results show the stability accuracy reaches 5μrad, and prove the effectiveness of the combined line-of-sight stabilization control system, and the real-time rapid prototype runs stable.

SOSS User Guide

NASA Technical Reports Server (NTRS)

Zhu, Zhifan; Gridnev, Sergei; Windhorst, Robert D.

2015-01-01

This User Guide describes SOSS (Surface Operations Simulator and Scheduler) software build and graphic user interface. SOSS is a desktop application that simulates airport surface operations in fast time using traffic management algorithms. It moves aircraft on the airport surface based on information provided by scheduling algorithm prototypes, monitors separation violation and scheduling conformance, and produces scheduling algorithm performance data.

The Simbol-X Low Energy Detector

NASA Astrophysics Data System (ADS)

Lechner, Peter

2009-05-01

For the Low Energy Detector of Simbol-X a new type of active pixel sensor based on the integrated amplifier DEPFET has been developed. This concept combines large area, scalable pixel size, low noise, and ultra-fast readout. Flight representative prototypes have been processed with a performance matching the Simbol-X specifications and demonstrating the technology readiness.

VHDL Descriptions for the FPGA Implementation of PWL-Function-Based Multi-Scroll Chaotic Oscillators

PubMed Central

2016-01-01

Nowadays, chaos generators are an attractive field for research and the challenge is their realization for the development of engineering applications. From more than three decades ago, chaotic oscillators have been designed using discrete electronic devices, very few with integrated circuit technology, and in this work we propose the use of field-programmable gate arrays (FPGAs) for fast prototyping. FPGA-based applications require that one be expert on programming with very-high-speed integrated circuits hardware description language (VHDL). In this manner, we detail the VHDL descriptions of chaos generators for fast prototyping from high-level programming using Python. The cases of study are three kinds of chaos generators based on piecewise-linear (PWL) functions that can be systematically augmented to generate even and odd number of scrolls. We introduce new algorithms for the VHDL description of PWL functions like saturated functions series, negative slopes and sawtooth. The generated VHDL-code is portable, reusable and open source to be synthesized in an FPGA. Finally, we show experimental results for observing 2, 10 and 30-scroll attractors. PMID:27997930

VHDL Descriptions for the FPGA Implementation of PWL-Function-Based Multi-Scroll Chaotic Oscillators.

PubMed

Tlelo-Cuautle, Esteban; Quintas-Valles, Antonio de Jesus; de la Fraga, Luis Gerardo; Rangel-Magdaleno, Jose de Jesus

2016-01-01

Nowadays, chaos generators are an attractive field for research and the challenge is their realization for the development of engineering applications. From more than three decades ago, chaotic oscillators have been designed using discrete electronic devices, very few with integrated circuit technology, and in this work we propose the use of field-programmable gate arrays (FPGAs) for fast prototyping. FPGA-based applications require that one be expert on programming with very-high-speed integrated circuits hardware description language (VHDL). In this manner, we detail the VHDL descriptions of chaos generators for fast prototyping from high-level programming using Python. The cases of study are three kinds of chaos generators based on piecewise-linear (PWL) functions that can be systematically augmented to generate even and odd number of scrolls. We introduce new algorithms for the VHDL description of PWL functions like saturated functions series, negative slopes and sawtooth. The generated VHDL-code is portable, reusable and open source to be synthesized in an FPGA. Finally, we show experimental results for observing 2, 10 and 30-scroll attractors.

Mass tracking and material accounting in the integral fast reactor (IFR)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orechwa, Y.; Adams, C.H.; White, A.M.

1991-01-01

This paper reports on the Integral Fast Reactor (IFR) which is a generic advanced liquid metal cooled reactor concept being developed at Argonne National Laboratory. There are a number of technical features of the IFR which contribute to its potential as a next-generation reactor. These are associated with large safety margins with regard to off-normal events involving the heat transport system, and the use of metallic fuel which makes possible the utilization of innovative fuel cycle processes. The latter feature permits fuel cycle closure with compact, low-cost reprocessing facilities, collocated with the reactor plant. These primary features are being demonstratedmore » in the facilities at ANL-West, utilizing Experimental Breeder Reactor II and the associated Fuel Cycle Facility (FCF) as an IFR prototype. The demonstration of this IFR prototype includes the design and implementation of the Mass-tracking System (MTG). In this system, data from the operations of the FCF, including weights and batch-process parameters, are collected and maintained by the MTG running on distributed workstations.« less

Application of a Virtual Reactivity Feedback Control Loop in Non-Nuclear Testing of a Fast Spectrum Reactor

NASA Technical Reports Server (NTRS)

Bragg-Sitton, Shannon M.; Forsbacka, Matthew

2004-01-01

For a compact, fast-spectrum reactor, reactivity feedback is dominated by core deformation at elevated temperature. Given the use of accurate deformation measurement techniques, it is possible to simulate nuclear feedback in non-nuclear electrically heated reactor tests. Implementation of simulated reactivity feedback in response to measured deflection is being tested at the NASA Marshall Space Flight Center Early Flight Fission Test Facility (EFF-TF). During tests of the SAFE-100 reactor prototype, core deflection was monitored using a high resolution camera. "virtual" reactivity feedback was accomplished by applying the results of Monte Carlo calculations (MCNPX) to core deflection measurements; the computational analysis was used to establish the reactivity worth of van'ous core deformations. The power delivered to the SAFE-100 prototype was then dusted accordingly via kinetics calculations, The work presented in this paper will demonstrate virtual reactivity feedback as core power was increased from 1 kilowatt(sub t), to 10 kilowatts(sub t), held approximately constant at 10 kilowatts (sub t), and then allowed to decrease based on the negative thermal reactivity coefficient.

The pharmacokinetics study of ginkgolide A, B and the effect of food on bioavailability after oral administration of ginkgolide extracts in beagle dogs.

PubMed

Aa, Lixiang; Fei, Fei; Tan, Zhaoyi; Aa, Jiye; Wang, Guangji; Liu, Changxiao

2018-06-01

Ginkgolides are the primarily active components in Ginkgo products that are popular worldwide. However, few studies have evaluated the bioavailability of ginkgolides and the effects of food on it after oral administration of ginkgolides. In this article, pharmacokinetics and absolute bioavailability of the primary components in ginkgolide extracts were evaluated in beagle dogs. For the first time, we showed that the fed dogs had significantly increased area under the concentration-time curve and peak concentration relative to the fasted dogs based on the data from both the prototype form and total lactones of ginkgolide A (GA) and ginkgolide B (GB). In terms of the free form of the prototype ginkgolides, the absolute bioavailabilities of GA and GB were 34.8 and 5.2% in the fasted dogs, respectively, which significantly increased to an average of 78.6 and 17.0%, respectively, in the fed dogs. In terms of acidified total lactones, the absolute bioavailabilities of GA and GB were 7.5 and 14.5% in the fed dogs, and the percentages declined to 4.1 and 3.7% in the fasted dogs, respectively. It was suggested that administration of ginkgolides after meals could promote the in vivo exposure and the bioavailability of GA and GB, and hence potentially enhance therapeutic outcomes. Copyright © 2018 John Wiley & Sons, Ltd.

Tactile-Foot Stimulation Can Assist the Navigation of People with Visual Impairment

PubMed Central

Velázquez, Ramiro; Pissaloux, Edwige; Lay-Ekuakille, Aimé

2015-01-01

Background. Tactile interfaces that stimulate the plantar surface with vibrations could represent a step forward toward the development of wearable, inconspicuous, unobtrusive, and inexpensive assistive devices for people with visual impairments. Objective. To study how people understand information through their feet and to maximize the capabilities of tactile-foot perception for assisting human navigation. Methods. Based on the physiology of the plantar surface, three prototypes of electronic tactile interfaces for the foot have been developed. With important technological improvements between them, all three prototypes essentially consist of a set of vibrating actuators embedded in a foam shoe-insole. Perceptual experiments involving direction recognition and real-time navigation in space were conducted with a total of 60 voluntary subjects. Results. The developed prototypes demonstrated that they are capable of transmitting tactile information that is easy and fast to understand. Average direction recognition rates were 76%, 88.3%, and 94.2% for subjects wearing the first, second, and third prototype, respectively. Exhibiting significant advances in tactile-foot stimulation, the third prototype was evaluated in navigation tasks. Results show that subjects were capable of following directional instructions useful for navigating spaces. Conclusion. Footwear providing tactile stimulation can be considered for assisting the navigation of people with visual impairments. PMID:27019593

Tactile-Foot Stimulation Can Assist the Navigation of People with Visual Impairment.

PubMed

Velázquez, Ramiro; Pissaloux, Edwige; Lay-Ekuakille, Aimé

2015-01-01

Background. Tactile interfaces that stimulate the plantar surface with vibrations could represent a step forward toward the development of wearable, inconspicuous, unobtrusive, and inexpensive assistive devices for people with visual impairments. Objective. To study how people understand information through their feet and to maximize the capabilities of tactile-foot perception for assisting human navigation. Methods. Based on the physiology of the plantar surface, three prototypes of electronic tactile interfaces for the foot have been developed. With important technological improvements between them, all three prototypes essentially consist of a set of vibrating actuators embedded in a foam shoe-insole. Perceptual experiments involving direction recognition and real-time navigation in space were conducted with a total of 60 voluntary subjects. Results. The developed prototypes demonstrated that they are capable of transmitting tactile information that is easy and fast to understand. Average direction recognition rates were 76%, 88.3%, and 94.2% for subjects wearing the first, second, and third prototype, respectively. Exhibiting significant advances in tactile-foot stimulation, the third prototype was evaluated in navigation tasks. Results show that subjects were capable of following directional instructions useful for navigating spaces. Conclusion. Footwear providing tactile stimulation can be considered for assisting the navigation of people with visual impairments.

High-Precision Pulse Generator

NASA Technical Reports Server (NTRS)

Katz, Richard; Kleyner, Igor

2011-01-01

A document discusses a pulse generator with subnanosecond resolution implemented with a low-cost field-programmable gate array (FPGA) at low power levels. The method used exploits the fast carry chains of certain FPGAs. Prototypes have been built and tested in both Actel AX and Xilinx Virtex 4 technologies. In-flight calibration or control can be performed by using a similar and related technique as a time interval measurement circuit by measuring a period of the stable oscillator, as the delays through the fast carry chains will vary as a result of manufacturing variances as well as the result of environmental conditions (voltage, aging, temperature, and radiation).

Fast Raman single bacteria identification: toward a routine in-vitro diagnostic

NASA Astrophysics Data System (ADS)

Douet, Alice; Josso, Quentin; Marchant, Adrien; Dutertre, Bertrand; Filiputti, Delphine; Novelli-Rousseau, Armelle; Espagnon, Isabelle; Kloster-Landsberg, Meike; Mallard, Frédéric; Perraut, Francois

2016-04-01

Timely microbiological results are essential to allow clinicians to optimize the prescribed treatment, ideally at the initial stage of the therapeutic process. Several approaches have been proposed to solve this issue and to provide the microbiological result in a few hours directly from the sample such as molecular biology. However fast and sensitive those methods are not based on single phenotypic information which presents several drawbacks and limitations. Optical methods have the advantage to allow single-cell sensitivity and to probe the phenotype of measured cells. Here we present a process and a prototype that allow automated single-bacteria phenotypic analysis. This prototype is based on the use of Digital In-line Holography techniques combined with a specially designed Raman spectrometer using a dedicated device to capture bacteria. The localization of single-cell is finely determined by using holograms and a proper propagation kernel. Holographic images are also used to analyze bacteria in the sample to sort potential pathogens from flora dwelling species or other biological particles. This accurate localization enables the use of a small confocal volume adapted to the measurement of single-cell. Along with the confocal volume adaptation, we also have modified every components of the spectrometer to optimize single-bacteria Raman measurements. This optimization allowed us to acquire informative single-cell spectra using an integration time of 0.5s only. Identification results obtained with this prototype are presented based on a 65144 Raman spectra database acquired automatically on 48 bacteria strains belonging to 8 species.

Experimental studies with two novel silicon detectors for the development of time-of-flight spectrometry of laser-accelerated proton beams

NASA Astrophysics Data System (ADS)

Würl, M.; Reinhardt, S.; Rosenfeld, A.; Petasecca, M.; Lerch, M.; Tran, L.; Karsch, S.; Assmann, W.; Schreiber, J.; Parodi, K.

2017-01-01

Laser-accelerated proton beams exhibit remarkably different beam characteristics as compared to conventionally accelerated ion beams. About 105 to 107 particles per MeV and msr are accelerated quasi-instantaneously within about 1 ps. The resulting energy spectrum typically shows an exponentially decaying distribution. Our planned approach to determine the energy spectrum of the particles generated in each pulse is to exploit the time-of-flight (TOF) difference of protons with different kinetic energies at 1 m distance from the laser-target interaction. This requires fast and sensitive detectors. We therefore tested two prototype silicon detectors, developed at the Centre for Medical Radiation Physics at the University of Wollongong with a current amplifier, regarding their suitability for TOF-spectrometry in terms of sensitivity and timing properties. For the latter, we illuminated the detectors with short laser pulses, measured the signal current and compared it to the signal of a fast photodiode. The comparison revealed that the timing properties of both prototypes are not yet sufficient for our purpose. In contrast, our results regarding the detectors’ sensitivity are promising. The lowest detectable proton flux at 10 MeV was found to be 25 protons per ns on the detector. With this sensitivity and with a smaller pixelation of the detectors, the timing properties can be improved for new prototypes, making them potential candidates for TOF-spectrometry of laser-accelerated particle beams.

Nondestructive Inspection System for Special Nuclear Material Using Inertial Electrostatic Confinement Fusion Neutrons and Laser Compton Scattering Gamma-Rays

NASA Astrophysics Data System (ADS)

Ohgaki, H.; Daito, I.; Zen, H.; Kii, T.; Masuda, K.; Misawa, T.; Hajima, R.; Hayakawa, T.; Shizuma, T.; Kando, M.; Fujimoto, S.

2017-07-01

A Neutron/Gamma-ray combined inspection system for hidden special nuclear materials (SNMs) in cargo containers has been developed under a program of Japan Science and Technology Agency in Japan. This inspection system consists of an active neutron-detection system for fast screening and a laser Compton backscattering gamma-ray source in coupling with nuclear resonance fluorescence (NRF) method for precise inspection. The inertial electrostatic confinement fusion device has been adopted as a neutron source and two neutron-detection methods, delayed neutron noise analysis method and high-energy neutron-detection method, have been developed to realize the fast screening system. The prototype system has been constructed and tested in the Reactor Research Institute, Kyoto University. For the generation of the laser Compton backscattering gamma-ray beam, a race track microtron accelerator has been used to reduce the size of the system. For the NRF measurement, an array of LaBr3(Ce) scintillation detectors has been adopted to realize a low-cost detection system. The prototype of the gamma-ray system has been demonstrated in the Kansai Photon Science Institute, National Institutes for Quantum and Radiological Science and Technology. By using numerical simulations based on the data taken from these prototype systems and the inspection-flow, the system designed by this program can detect 1 kg of highly enriched 235U (HEU) hidden in an empty 20-ft container within several minutes.

Integration of homeostatic signaling and food reward processing in the human brain

PubMed Central

Simon, Joe J.; Wetzel, Anne; Sinno, Maria Hamze; Skunde, Mandy; Bendszus, Martin; Enck, Paul; Herzog, Wolfgang; Friederich, Hans-Christoph

2017-01-01

BACKGROUND. Food intake is guided by homeostatic needs and by the reward value of food, yet the exact relation between the two remains unclear. The aim of this study was to investigate the influence of different metabolic states and hormonal satiety signaling on responses in neural reward networks. METHODS. Twenty-three healthy participants underwent functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food- or monetary-related reward. Every participant was scanned twice in a counterbalanced fashion, both during a fasted state (after 24 hours fasting) and satiety. A functional connectivity analysis was performed to investigate the influence of satiety signaling on activation in neural reward networks. Blood samples were collected to assess hormonal satiety signaling. RESULTS. Fasting was associated with sensitization of the striatal reward system to the anticipation of food reward irrespective of reward magnitude. Furthermore, during satiety, individual ghrelin levels were associated with increased neural processing during the expectation of food-related reward. CONCLUSIONS. Our findings show that physiological hunger stimulates food consumption by specifically increasing neural processing during the expectation (i.e., incentive salience) but not the receipt of food-related reward. In addition, these findings suggest that ghrelin signaling influences hedonic-driven food intake by increasing neural reactivity during the expectation of food-related reward. These results provide insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward. TRIAL REGISTRATION. ClinicalTrials.gov NCT03081585. FUNDING. This work was supported by the German Competence Network on Obesity, which is funded by the German Federal Ministry of Education and Research (FKZ 01GI1122E). PMID:28768906

Preparatory Study for Constructing FAST, the World's Largest Single Dish

NASA Astrophysics Data System (ADS)

Peng, Bo; Jin, Chengjin; Wang, Qiming; Zhu, Lichun; Zhu, Wenbai; Zhang, Haiyan; Nan, Rendong

2009-08-01

A 500-m aperture spherical telescope (FAST) was funded by the National Development and Reform Commission of China (NDRC) in July 2007 and will be located in the unique Karst region, a sinkhole-like landform, in Guizhou province. FAST can be seen as a modified "Arecibo" type radio telescope using many innovative techniques, with as much as twice the collecting area and a wider sky coverage. FAST has, first, an active reflector, conforming to a paraboloid of revolution from a sphere in real time through actuated control, which enables the realization of wide bandwidth and full polarization capability by using standard feed design. Secondly, it has a light focus cabin suspension system, integrating optical, mechanical, and electronic technologies, reducing effectively the cost of the support structure and control system. With such a huge collecting area of more than 30 football fields, FAST will become the largest single dish ever built. Here we will summarize the FAST concept and the milestones achieved in experiments on its key technologies, i.e., site exploration, active reflector prototyping, focus cabin driving mechanism, measurement and control techniques, and the receiver layout. The Miyun FAST demonstrator also will be presented.

Unsteady jet in designing innovative drug delivery system

NASA Astrophysics Data System (ADS)

Wang, Cong; Mazur, Paul; Cosse, Julia; Rider, Stephanie; Gharib, Morteza

2014-11-01

Micro-needle injections, a promising pain-free drug delivery method, is constrained by its limited penetration depth. This deficiency can be overcome by implementing fast unsteady jet that can penetrate sub-dermally. The development of a faster liquid jet would increase the penetration depth and delivery volume of micro-needles. In this preliminary work, the nonlinear transient behavior of an elastic tube balloon in providing fast discharge is analyzed. A physical model that combines the Mooney Rivlin Material model and Young-Lapalce's Law was developed and used to investigate the fast discharging dynamic phenomenon. A proof of concept prototype was constructed to demonstrate the feasibility of a simple thumb-sized delivery system to generate liquid jet with desired speed in the range of 5-10 m/s. This work is supported by ZCUBE Corporation.

Advanced technology for space shuttle auxiliary propellant valves

NASA Technical Reports Server (NTRS)

Wichmann, H.

1973-01-01

Valves for the gaseous hydrogen/gaseous oxygen shuttle auxiliary propulsion system are required to feature low leakage over a wide temperature range coupled with high cycle life, long term compatibility and minimum maintenance. In addition, those valves used as thruster shutoff valves must feature fast response characteristics to achieve small, repeatable minimum impulse bits. These valve technology problems are solved by developing unique valve components such as sealing closures, guidance devices, and actuation means and by demonstrating two prototype valve concepts. One of the prototype valves is cycled over one million cycles without exceeding a leakage rate of 27 scc's per hour at 450 psia helium inlet pressure throughout the cycling program.

Reverse-mode PSLC multi-plane optical see-through display for AR applications.

PubMed

Liu, Shuxin; Li, Yan; Zhou, Pengcheng; Chen, Quanming; Su, Yikai

2018-02-05

In this paper we propose an optical see-through multi-plane display with reverse-mode polymer-stabilized liquid crystal (PSLC). Our design solves the problem of accommodation-vergence conflict with correct focus cues. In the reverse mode PSLC system, power consumption could be reduced to ~1/(N-1) of that in a normal mode system if N planes are displayed. The PSLC films fabricated in our experiment exhibit a low saturation voltage ~20 V rms , a high transparent-state transmittance (92%), and a fast switching time within 2 ms and polarization insensitivity. A proof-of-concept two-plane color display prototype and a four-plane monocolor display prototype were implemented.

Atom-chip based quantum gravimetry for the precise determination of absolute local gravity

NASA Astrophysics Data System (ADS)

Abend, S.

2015-12-01

We present a novel technique for the precise measurement of absolute local gravity based on cold atom interferometry. Atom interferometry utilizes the interference of matter waves interrogated by laser light to read out inertial forces. Today's generation of these devices typically operate with test mass samples, that consists of ensembles of laser cooled atoms. Their performance is limited by the velocity spread and finite-size of the test masses that impose systematic uncertainties at the level of a few μGal. Rather than laser cooled atoms we employ quantum degenerate ensembles, so called Bose-Einstein condensates, as ultra-sensitive probes for gravity. These sources offer unique properties in temperature as well as in ensemble size that will allow to overcome the current limitations with the next generation of sensors. Furthermore, atom-chip technologies offer the possibility to generate Bose-Einstein condensates in a fast and reliable way. We show a lab-based prototype that uses the atom-chip itself to retro-reflect the interrogation laser and thus serving as inertial reference inside the vacuum. With this setup it is possible to demonstrate all necessary steps to measure gravity, including the preparation of the source, spanning an interferometer as well as the detection of the output signal, within an area of 1 cm3 right below the atom-chip and to analyze relevant systematic effects. In the framework of the center of excellence geoQ a next generation device is under construction at the Institut für Quantenoptik, that will allow for in-field measurements. This device will feature a state-of-the-art atom-chip source with a high-flux of ultra-cold atoms at a repetition rate of 1-2 Hz. In cooperation with the Müller group at the Institut für Erdmessung the sensor will be characterized in the laboratory first, to be ultimately employed in campaigns to measure the Fennoscandian uplift at the level of 1 μGal. The presented work is part of the center of excellence geoQ (SFB 1128), funded by the Deutsche Forschungsgemeinschaft (DFG). This work is supported by the German Space Agency (DLR) with funds provided by the Federal Ministry for Economic Affairs and Energy (BMWi) due to an enactment of the German Bundestag under grant numbers DLR 50 1131-1137 (QUANTUS-III).

Federal Motor Carrier Safety Administration’s advanced system testing utilizing a data acquisition system on the highways (FAST DASH) safety technology evaluation project #3 : novel convex mirrors.

DOT National Transportation Integrated Search

2016-11-01

An independent evaluation of a set of novel prototype mirrors was conducted to determine whether the mirrors perform as well as traditional production mirrors across the basic functions of field of view (FOV), image distortion, and distance estimatio...

Autonomy and Sensor Webs: The Evolution of Mission Operations

NASA Technical Reports Server (NTRS)

Sherwood, Rob

2008-01-01

Demonstration of these sensor web capabilities will enable fast responding science campaigns that combine spaceborne, airborne, and ground assets. Sensor webs will also require new operations paradigms. These sensor webs will be operated directly by scientists using science goals to control their instruments. We will explore these new operations architectures through a study of existing sensor web prototypes.

Transmutation of All German Transuranium under Nuclear Phase Out Conditions – Is This Feasible from Neutronic Point of View?

PubMed Central

Merk, Bruno; Litskevich, Dzianis

2015-01-01

The German government has decided for the nuclear phase out, but a decision on a strategy for the management of the highly radioactive waste is not defined yet. Partitioning and Transmutation (P&T) could be considered as a technological option for the management of highly radioactive waste, therefore a wide study has been conducted. In the study group objectives for P&T and the boundary conditions of the phase out have been discussed. The fulfillment of the given objectives is analyzed from neutronics point of view using simulations of a molten salt reactor with fast neutron spectrum. It is shown that the efficient transmutation of all existing transuranium isotopes would be possible from neutronic point of view in a time frame of about 60 years. For this task three reactors of a mostly new technology would have to be developed and a twofold life cycle consisting of a transmuter operation and a deep burn phase would be required. A basic insight for the optimization of the time duration of the deep burn phase is given. Further on, a detailed balance of different isotopic inventories is given to allow a deeper understanding of the processes during transmutation in the molten salt fast reactor. The effect of modeling and simulation is investigated based on three different modeling strategies and two different code versions. PMID:26717509

Transmutation of All German Transuranium under Nuclear Phase Out Conditions - Is This Feasible from Neutronic Point of View?

PubMed

Merk, Bruno; Litskevich, Dzianis

2015-01-01

The German government has decided for the nuclear phase out, but a decision on a strategy for the management of the highly radioactive waste is not defined yet. Partitioning and Transmutation (P&T) could be considered as a technological option for the management of highly radioactive waste, therefore a wide study has been conducted. In the study group objectives for P&T and the boundary conditions of the phase out have been discussed. The fulfillment of the given objectives is analyzed from neutronics point of view using simulations of a molten salt reactor with fast neutron spectrum. It is shown that the efficient transmutation of all existing transuranium isotopes would be possible from neutronic point of view in a time frame of about 60 years. For this task three reactors of a mostly new technology would have to be developed and a twofold life cycle consisting of a transmuter operation and a deep burn phase would be required. A basic insight for the optimization of the time duration of the deep burn phase is given. Further on, a detailed balance of different isotopic inventories is given to allow a deeper understanding of the processes during transmutation in the molten salt fast reactor. The effect of modeling and simulation is investigated based on three different modeling strategies and two different code versions.

Prototype of a coherent tracking and detection receiver with wideband vibration compensation for free-space laser communications

NASA Astrophysics Data System (ADS)

Giggenbach, Dirk; Schex, Anton; Wandernoth, Bernhard

1996-04-01

The Optical Communications Group of the German Aerospace Research Establishment (DLR) has investigated the feasibility of a fiberless receiver telescope for high sensitive coherent optical space communication, resulting in an elegant pointing, acquisition and tracking (PAT) concept. To demonstrate the feasibility of this new concept, an optical receiver terminal that coherently obtains both the spatial error signal for tracking and the data signal with only one set of detectors has been built. The result is a very simple and compact setup with few optical surfaces. It does not require fibers for superpositioning and is capable to compensate for microaccelerations up to about one kilohertz.

Dismantling of Highly Contaminated Process Installations of the German Reprocessing Facility (WAK) - Status of New Remote Handling Technology - 13287

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dux, Joachim; Friedrich, Daniel; Lutz, Werner

2013-07-01

Decommissioning and dismantling of the former German Pilot Reprocessing Plant Karlsruhe (WAK) including the Vitrification Facility (VEK) is being executed in different Project steps related to the reprocessing, HLLW storage and vitrification complexes /1/. While inside the reprocessing building the total inventory of process equipment has already been dismantled and disposed of, the HLLW storage and vitrification complex has been placed out of operation since vitrification and tank rinsing procedures where finalized in year 2010. This paper describes the progress made in dismantling of the shielded boxes of the highly contaminated laboratory as a precondition to get access to themore » hot cells of the HLLW storage. The major challenges of the dismantling of this laboratory were the high dose rates up to 700 mSv/h and the locking technology for the removal of the hot cell installations. In parallel extensive prototype testing of different carrier systems and power manipulators to be applied to dismantle the HLLW-tanks and other hot cell equipment is ongoing. First experiences with the new manipulator carrier system and a new master slave manipulator with force reflection will be reported. (authors)« less

Digital prototyping technique applied for redesigning plastic products

NASA Astrophysics Data System (ADS)

Pop, A.; Andrei, A.

2015-11-01

After products are on the market for some time, they often need to be redesigned to meet new market requirements. New products are generally derived from similar but outdated products. Redesigning a product is an important part of the production and development process. The purpose of this paper is to show that using modern technology, like Digital Prototyping in industry is an effective way to produce new products. This paper tries to demonstrate and highlight the effectiveness of the concept of Digital Prototyping, both to reduce the design time of a new product, but also the costs required for implementing this step. The results of this paper show that using Digital Prototyping techniques in designing a new product from an existing one available on the market mould offers a significantly manufacturing time and cost reduction. The ability to simulate and test a new product with modern CAD-CAM programs in all aspects of production (designing of the 3D model, simulation of the structural resistance, analysis of the injection process and beautification) offers a helpful tool for engineers. The whole process can be realised by one skilled engineer very fast and effective.

FAST: FAST Analysis of Sequences Toolbox

PubMed Central

Lawrence, Travis J.; Kauffman, Kyle T.; Amrine, Katherine C. H.; Carper, Dana L.; Lee, Raymond S.; Becich, Peter J.; Canales, Claudia J.; Ardell, David H.

2015-01-01

FAST (FAST Analysis of Sequences Toolbox) provides simple, powerful open source command-line tools to filter, transform, annotate and analyze biological sequence data. Modeled after the GNU (GNU's Not Unix) Textutils such as grep, cut, and tr, FAST tools such as fasgrep, fascut, and fastr make it easy to rapidly prototype expressive bioinformatic workflows in a compact and generic command vocabulary. Compact combinatorial encoding of data workflows with FAST commands can simplify the documentation and reproducibility of bioinformatic protocols, supporting better transparency in biological data science. Interface self-consistency and conformity with conventions of GNU, Matlab, Perl, BioPerl, R, and GenBank help make FAST easy and rewarding to learn. FAST automates numerical, taxonomic, and text-based sorting, selection and transformation of sequence records and alignment sites based on content, index ranges, descriptive tags, annotated features, and in-line calculated analytics, including composition and codon usage. Automated content- and feature-based extraction of sites and support for molecular population genetic statistics make FAST useful for molecular evolutionary analysis. FAST is portable, easy to install and secure thanks to the relative maturity of its Perl and BioPerl foundations, with stable releases posted to CPAN. Development as well as a publicly accessible Cookbook and Wiki are available on the FAST GitHub repository at https://github.com/tlawrence3/FAST. The default data exchange format in FAST is Multi-FastA (specifically, a restriction of BioPerl FastA format). Sanger and Illumina 1.8+ FastQ formatted files are also supported. FAST makes it easier for non-programmer biologists to interactively investigate and control biological data at the speed of thought. PMID:26042145

Optical delay encoding for fast timing and detector signal multiplexing in PET

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grant, Alexander M.; Levin, Craig S., E-mail: cslevin@stanford.edu; Molecular Imaging Program at Stanford

2015-08-15

Purpose: The large number of detector channels in modern positron emission tomography (PET) scanners poses a challenge in terms of readout electronics complexity. Multiplexing schemes are typically implemented to reduce the number of physical readout channels, but often result in performance degradation. Novel methods of multiplexing in PET must be developed to avoid this data degradation. The preservation of fast timing information is especially important for time-of-flight PET. Methods: A new multiplexing scheme based on encoding detector interaction events with a series of extremely fast overlapping optical pulses with precise delays is demonstrated in this work. Encoding events in thismore » way potentially allows many detector channels to be simultaneously encoded onto a single optical fiber that is then read out by a single digitizer. A two channel silicon photomultiplier-based prototype utilizing this optical delay encoding technique along with dual threshold time-over-threshold is demonstrated. Results: The optical encoding and multiplexing prototype achieves a coincidence time resolution of 160 ps full width at half maximum (FWHM) and an energy resolution of 13.1% FWHM at 511 keV with 3 × 3 × 5 mm{sup 3} LYSO crystals. All interaction information for both detectors, including timing, energy, and channel identification, is encoded onto a single optical fiber with little degradation. Conclusions: Optical delay encoding and multiplexing technology could lead to time-of-flight PET scanners with fewer readout channels and simplified data acquisition systems.« less

Study of a novel electromagnetic liquid argon calorimeter — the TGT

NASA Astrophysics Data System (ADS)

Berger, C.; Braunschweig, W.; Geulig, E.; Schöntag, M.; Siedling, R.; Wlochal, M.; Putzer, A.; Wotschack, J.; Cheplakov, A.; Feshchenko, A.; Kazarinov, M.; Kukhtin, V.; Ladygin, E.; Obudovskij, V.; Geweniger, C.; Hanke, P.; Kluge, E.-E.; Krause, J.; Schmidt, M.; Stenzel, H.; Tittel, K.; Wunsch, M.; Zerwas, D.; Bruncko, D.; Jusko, A.; Kocper, B.; Lupták, M.; Aderholz, M.; Bán, J.; Brettel, H.; Dydak, F.; Fent, J.; Frey, H.; Huber, J.; Jakobs, K.; Kiesling, C.; Kiryunin, A. E.; Oberlack, H.; Ribarics, P.; Schacht, P.; Stiegler, U.; Bogolyubsky, M. Y.; Buyanov, O. V.; Chekulaev, S. V.; Kurchaninov, L. L.; Levitsky, M. S.; Maximov, V. V.; Minaenko, A. A.; Moiseev, A. M.; Semenov, P. A.; Tikhonov, V. V.; Straumann, U.

1995-02-01

The concept and the basic design of a fast, highly granular and compact electromagnetic liquid argon calorimeter are described. This novel calorimeter offers uniform energy response and constant energy resolution independent of the production angle of an impinging particle and of its impact position at the calorimeter. An example of a calorimeter with full rapidity coverage in an application in a collider detector is given. An important aspect of the concept is the electronics for fast signal processing matched to the short charge collection time. We report on the experience with the realization of a prototype calorimeter module and on its performance in a testbeam exposure.

High performance MPEG-audio decoder IC

NASA Technical Reports Server (NTRS)

Thorn, M.; Benbassat, G.; Cyr, K.; Li, S.; Gill, M.; Kam, D.; Walker, K.; Look, P.; Eldridge, C.; Ng, P.

1993-01-01

The emerging digital audio and video compression technology brings both an opportunity and a new challenge to IC design. The pervasive application of compression technology to consumer electronics will require high volume, low cost IC's and fast time to market of the prototypes and production units. At the same time, the algorithms used in the compression technology result in complex VLSI IC's. The conflicting challenges of algorithm complexity, low cost, and fast time to market have an impact on device architecture and design methodology. The work presented in this paper is about the design of a dedicated, high precision, Motion Picture Expert Group (MPEG) audio decoder.

Data Acquisition System for Silicon Ultra Fast Cameras for Electron and Gamma Sources in Medical Applications (sucima Imager)

NASA Astrophysics Data System (ADS)

Czermak, A.; Zalewska, A.; Dulny, B.; Sowicki, B.; Jastrząb, M.; Nowak, L.

2004-07-01

The needs for real time monitoring of the hadrontherapy beam intensity and profile as well as requirements for the fast dosimetry using Monolithic Active Pixel Sensors (MAPS) forced the SUCIMA collaboration to the design of the unique Data Acquisition System (DAQ SUCIMA Imager). The DAQ system has been developed on one of the most advanced XILINX Field Programmable Gate Array chip - VERTEX II. The dedicated multifunctional electronic board for the detector's analogue signals capture, their parallel digital processing and final data compression as well as transmission through the high speed USB 2.0 port has been prototyped and tested.

Automated nystagmus analysis. [on-line computer technique for eye data processing

NASA Technical Reports Server (NTRS)

Oman, C. M.; Allum, J. H. J.; Tole, J. R.; Young, L. R.

1973-01-01

Several methods have recently been used for on-line analysis of nystagmus: A digital computer program has been developed to accept sampled records of eye position, detect fast phase components, and output cumulative slow phase position, continuous slow phase velocity, instantaneous fast phase frequency, and other parameters. The slow phase velocity is obtained by differentiation of the calculated cumulative position rather than the original eye movement record. Also, a prototype analog device has been devised which calculates the velocity of the slow phase component during caloric testing. Examples of clinical and research eye movement records analyzed with these devices are shown.

Load characteristics of a suspended carbon nanotube film heater and the fabrication of a fast-response thermochromic display prototype.

PubMed

Liu, Peng; Zhou, Duanliang; Wei, Yang; Jiang, Kaili; Wang, Jiaping; Zhang, Lina; Li, Qunqing; Fan, Shoushan

2015-04-28

The influence of heating load on the thermal response of a CNT film heater has been studied. Two kinds of heat dissipation modes, thermal radiation in a vacuum and convection in the atmosphere, are investigated, respectively. It is found that the thermal response slows down with the load quantities in the both cases. We have further studied the thermal response of a CNT film loaded with thermochromic pigment, which is a kind of phase change material. In addition to the thermal response slowing down with the load quantity, it is also found that the phase change of the thermochromic pigments can also slow down the thermal response. With a suspended CNT film heater structure, we have fabricated a thermochromic display prototype, which can switch from room temperature to 50 °C in about 1 s with a brightness contrast of 4.8 under normal indoor illumination. A 16 × 16 pixel thermochromic display prototype can dynamically display Chinese characters driven by a homemade circuit.

Construction of the optical part of a time-of-flight detector prototype for the AFP detector

DOE PAGES

Nozka, L.; Adamczyk, L.; Avoni, G.; ...

2016-11-22

We present the construction of the optical part of the ToF (time-of-flight) subdetector prototype for the AFP (ATLAS Forward Proton) detector. The ToF detector in conjunction with a 3D silicon pixel tracker will tag and measure protons originating in central exclusive interactions p + p → p + X + p, where the two outgoing protons are scattered in the very forward directions. The ToF is required to reduce so-called pileup backgrounds that arise from multiple proton interactions in the same bunch crossing at high luminosity. The background can fake the signal of interest, and the extra rejection from themore » ToF allows the proton tagger to operate at the high luminosity required for measurement of the processes. The prototype detector uses fused silica bars emitting Cherenkov radiation as a relativistic particle passes through it. Finally, the emitted Cherenkov photons are detected by a micro-channel plate multi-anode Photomultiplier Tube (MCP-PMT) and processed by fast electronics.« less

Construction of the optical part of a time-of-flight detector prototype for the AFP detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nozka, L.; Adamczyk, L.; Avoni, G.

We present the construction of the optical part of the ToF (time-of-flight) subdetector prototype for the AFP (ATLAS Forward Proton) detector. The ToF detector in conjunction with a 3D silicon pixel tracker will tag and measure protons originating in central exclusive interactions p + p → p + X + p, where the two outgoing protons are scattered in the very forward directions. The ToF is required to reduce so-called pileup backgrounds that arise from multiple proton interactions in the same bunch crossing at high luminosity. The background can fake the signal of interest, and the extra rejection from themore » ToF allows the proton tagger to operate at the high luminosity required for measurement of the processes. The prototype detector uses fused silica bars emitting Cherenkov radiation as a relativistic particle passes through it. Finally, the emitted Cherenkov photons are detected by a micro-channel plate multi-anode Photomultiplier Tube (MCP-PMT) and processed by fast electronics.« less

Prototype of a Standards-Based EHR and Genetic Test Reporting Tool Coupled with HL7-Compliant Infobuttons

PubMed Central

Crump, Jacob K.; Del Fiol, Guilherme; Williams, Marc S.; Freimuth, Robert R.

2018-01-01

Integration of genetic information is becoming increasingly important in clinical practice. However, genetic information is often ambiguous and difficult to understand, and clinicians have reported low-self-efficacy in integrating genetics into their care routine. The Health Level Seven (HL7) Infobutton standard helps to integrate online knowledge resources within Electronic Health Records (EHRs) and is required for EHR certification in the US. We implemented a prototype of a standards-based genetic reporting application coupled with infobuttons leveraging the Infobutton and Fast Healthcare Interoperability Resources (FHIR) Standards. Infobutton capabilities were provided by Open Infobutton, an open source package compliant with the HL7 Infobutton Standard. The resulting prototype demonstrates how standards-based reporting of genetic results, coupled with curated knowledge resources, can provide dynamic access to clinical knowledge on demand at the point of care. The proposed functionality can be enabled within any EHR system that has been certified through the US Meaningful Use program.

Wireless optical network for a home network

NASA Astrophysics Data System (ADS)

Bouchet, Olivier; Porcon, Pascal; Walewski, Joachim W.; Nerreter, Stefan; Langer, Klaus-Dieter; Fernández, Luz; Vucic, Jelena; Kamalakis, Thomas; Ntogari, Georgia; Neokosmidis, Ioannis; Gueutier, Eric

2010-08-01

During the European collaborative project OMEGA, two optical-wireless prototypes have been developed. The first prototype operates in the near-infrared spectral region and features Giga Ethernet connectivity, a simple transceiver architecture due to the use of on-off keying, a multi-sector transceiver, and an ultra-fast switch for sector-to-sector hand over. This full-duplex system, composed by one base station and one module, transmits data on three meters. The second prototype is a visible-light-communications system based on DMT signal processing and an adapted MAC sublayer. Data rates around to 100 Mb/s at the physical layer are achieved. This broadcast system, composed also by one base station and one module, transmits data up to two meters. In this paper we present the adapted optical wireless media-access-control sublayer protocol for visible-light communications. This protocol accommodates link adaptation from 128 Mb/s to 1024 Mb/s with multi-sector coverage, and half-duplex or full-duplex transmission.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deng, Zhiqun; Carlson, Thomas J.; Fu, Tao

Power extracted from fast moving tidal currents has been identified as a potential commercial-scale source of renewable energy. Device developers and utilities are pursuing deployment of prototype tidal turbines to assess technology viability, site feasibility, and environmental interactions. Deployment of prototype turbines requires permits from a range of regulatory authorities. Ensuring the safety of marine animals, particularly those under protection of the Endangered Species Act of 1973 (ESA) and the Marine Mammal Protection Act of 1972 has emerged as a key regulatory challenge for initial MHK deployments. The greatest perceived risk to marine animals is from strike by the rotatingmore » blades of tidal turbines. Development of the marine mammal alert system (MAAS) was undertaken to support monitoring and mitigation requirements for tidal turbine deployments. The prototype system development focused on Southern Resident killer whales (SRKW), an endangered population of killer whales that frequents Puget Sound and is intermittently present in the part of the sound where deployment of prototype tidal turbines is being considered. Passive acoustics were selected as the primary means because of the vocal nature of these animals. The MAAS passive acoustic system consists of two-stage process involving the use of an energy detector and a spectrogram-based classifier to distinguish between SKRW’s calls and noise. A prototype consisting of two 2D symmetrical star arrays separated by 20 m center to center was built and evaluated in the waters of Sequim Bay using whale call playback.« less

Two-axis gimbal for air-to-air and air-to-ground laser communications

NASA Astrophysics Data System (ADS)

Talmor, Amnon G.; Harding, Harvard; Chen, Chien-Chung

2016-03-01

For bi-directional links between high-altitude-platforms (HAPs) and ground, and air-to-air communication between such platforms, a hemispherical +30°C field-of-regard and low-drag low-mass two-axis gimbal was designed and prototyped. The gimbal comprises two servo controlled non-orthogonal elevation over azimuth axis, and inner fast steering mirrors for fine field-of-regard adjustment. The design encompasses a 7.5cm diameter aperture refractive telescope in its elevation stage, folded between two flat mirrors with an exit lens leading to a two mirrors miniature Coude-path fixed to the azimuth stage. Multiple gimbal configurations were traded prior to finalizing a selection that met the requirements. The selected design was manifested onboard a carbon fiber and magnesium composite structure, motorized by custom-built servo motors, and commutated by optical encoders. The azimuth stage is electrically connected to the stationary base via slip ring while the elevation stage made of passive optics. Both axes are aligned by custom-built ceramic-on-steel angular contact duplex bearings, and controlled by embedded electronics featuring a rigid-flex PCB architecture. FEA analysis showed that the design is mechanically robust over a temperature range of +60°C to -80°C, and with first mode of natural frequencies above 400Hz. The total mass of the prototyped gimbal is 3.5kg, including the inner optical bench, which contains fast steering mirrors (FSMs) and tracking sensors. Future version of this gimbal, in prototyping stage, shall weigh less than 3.0kg.

Usability of a mobile electronic medical record prototype: a verbal protocol analysis.

PubMed

Wu, Robert C; Orr, M Scott; Chignell, Mark; Straus, Sharon E

2008-06-01

Point of care access to electronic medical records may provide clinicians with the information they want when they need it and may in turn improve patient safety. Yet providing an electronic medical record on handheld devices presents many usability challenges, and it is unclear whether clinicians will use them. An iterative design process for the development and evaluation of a prototype of a mobile electronic medical record was performed. Usability sessions were conducted in which physicians were asked to 'think aloud' while working through clinical scenarios using the prototype. Verbal protocol analysis, which consists of coding utterances, was conducted on the transcripts from the sessions and common themes were extracted. Usability sessions were held with five family physicians and four internists with varying levels of computer expertise. Physicians were able to use the device to complete 52 of 54 required tasks. Users commented that it was intuitive (9/9), would increase accessibility (5/9) but for them to use it, it would need the system to be fast and time-saving (5/9). Users had difficulty entering information (5/9) and reading the screen (4/9). In terms of functionality, users had concerns about completeness of information (6/9), details of ordering (5/9) and desired billing functionality (5/9) and integration with other systems (4/9). While physicians can use mobile electronic medical records in realistic scenarios, certain requirements likely need to be met including a fast system with easy data selection, easy data entry and improved display before widespread adoption occurs.

International Space Station Alpha (ISSA) Integrated Traffic Model

NASA Technical Reports Server (NTRS)

Gates, R. E.

1995-01-01

The paper discusses the development process of the International Space Station Alpha (ISSA) Integrated Traffic Model which is a subsystem analyses tool utilized in the ISSA design analysis cycles. Fast-track prototyping of the detailed relationships between daily crew and station consumables, propellant needs, maintenance requirements and crew rotation via spread sheets provide adequate benchmarks to assess cargo vehicle design and performance characteristics.

Microscope-on-Chip Using Micro-Channel and Solid State Image Sensors

NASA Technical Reports Server (NTRS)

Wang, Yu

2000-01-01

Recently, Jet Propulsion Laboratory has invented and developed a miniature optical microscope, microscope-on-chip using micro-channel and solid state image sensors. It is lightweight, low-power, fast speed instrument, it has no image lens, does not need focus adjustment, and the total mass is less than 100g. A prototype has been built and demonstrated at JPL.

The Use of Video Technology for the Fast-Prototyping of Artificially Intelligent Software.

ERIC Educational Resources Information Center

Klein, Gary L.

This paper describes the use of video to provide a screenplay depiction of a proposed artificial intelligence software system. Advantages of such use are identified: (1) the video can be used to provide a clear conceptualization of the proposed system; (2) it can illustrate abstract technical concepts; (3) it can simulate the functions of the…

Multivariate interactive digital analysis system /MIDAS/ - A new fast multispectral recognition system

NASA Technical Reports Server (NTRS)

Kriegler, F.; Marshall, R.; Lampert, S.; Gordon, M.; Cornell, C.; Kistler, R.

1973-01-01

The MIDAS system is a prototype, multiple-pipeline digital processor mechanizing the multivariate-Gaussian, maximum-likelihood decision algorithm operating at 200,000 pixels/second. It incorporates displays and film printer equipment under control of a general purpose midi-computer and possesses sufficient flexibility that operational versions of the equipment may be subsequently specified as subsets of the system.

BabelFish-Tools for IEEE C37.118.2-compliant real-time synchrophasor data mediation

NASA Astrophysics Data System (ADS)

Almas, M. S.; Vanfretti, L.; Baudette, M.

BabelFish (BF) is a real-time data mediator for development and fast prototyping of synchrophasor applications. BF is compliant with the synchrophasor data transmission IEEE Std C37.118.2-2011. BF establishes a TCP/IP connection with any Phasor Measurement Unit (PMU) or Phasor Data Concentrator (PDC) stream and parses the IEEE Std C37.118.2-2011 frames in real-time to provide access to raw numerical data in the LabVIEW environment. Furthermore, BF allows the user to select "data-of-interest" and transmit it to either a local or remote application using the User Datagram Protocol (UDP) in order to support both unicast and multicast communication. In the power systems Wide Area Monitoring Protection and Control (WAMPAC) domain, BF provides the first Free/Libre and Open Source Software (FLOSS) for the purpose of giving the users tools for fast prototyping of new applications processing PMU measurements in their chosen environment, thus liberating them of time consuming synchrophasor data handling and allowing them to develop applications in a modular fashion, without a need of a large and monolithic synchrophasor software environment.

Smart monolithic integration of inkjet printed thermal flow sensors with fast prototyping polymer microfluidics

NASA Astrophysics Data System (ADS)

Etxebarria, Ikerne; Elizalde, Jorge; Pacios, Roberto

2016-08-01

There is an increasing demand for built-in flow sensors in order to effectively control microfluidic processes due to the high number of available microfluidic applications. The possible solutions should be inexpensive and easy to connect to both, the microscale features and the macro setup. In this paper, we present a novel approach to integrate a printed thermal flow sensor with polymeric microfluidic channels. This approach is focused on merging two high throughput production processes, namely inkjet printing and fast prototyping technologies, in order to produce trustworthy and low cost devices. These two technologies are brought together to obtain a sensor located outside the microfluidic device. This avoids the critical contact between the sensor material and the fluids through the microchannels that can seriously damage the conducting paths under continuous working regimes. In this way, we ensure reliable and stable operation modes. For this application, a silver nanoparticle based ink and cyclic olefin polymer were used. This flow sensor operates linearly in the range of 0-10 μl min-1 for water and 0-20 μl min-1 for ethanol in calorimetric mode. Switching to anemometric mode, the range can be expanded up to 40 μl min-1.

The Endcap Disc DIRC of PANDA

NASA Astrophysics Data System (ADS)

Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Cowie, E.; Keri, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.

2017-12-01

The Endcap Disc DIRC (EDD) for PANDA has been designed to identify traversing pions, kaons and protons in the future PANDA experiment. Its central part is a 2 cm thick fused silica plate. Focussing optics are attached to the outer rim of the plate, outside of the acceptance of the experiment. Fast, high-resolution MCP-PMTs, designed to register single Cherenkov photons, have been tested in magnetic field. Filters limit the spectral acceptance of the sensors to reduce dispersion effects and to extend their lifetime. A compact and fast readout is realized with ASICs. Analytical reconstruction algorithms allow for fast particle identification. The angular resolution of a DIRC prototype has been simulated in Monte Carlo and confirmed in a test beam. The final detector will be able to provide a 4 σπ / K separation up to a momentum of 4 GeV / c .

Detection of fast neutrons from shielded nuclear materials using a semiconductor alpha detector.

PubMed

Pöllänen, R; Siiskonen, T

2014-08-01

The response of a semiconductor alpha detector to fast (>1 MeV) neutrons was investigated by using measurements and simulations. A polyethylene converter was placed in front of the detector to register recoil protons generated by elastic collisions between neutrons and hydrogen nuclei of the converter. The developed prototype equipment was tested with shielded radiation sources. The low background of the detector and insensitivity to high-energy gamma rays above 1 MeV are advantages when the detection of neutron-emitting nuclear materials is of importance. In the case of a (252)Cf neutron spectrum, the intrinsic efficiency of fast neutron detection was determined to be 2.5×10(-4), whereas three-fold greater efficiency was obtained for a (241)AmBe neutron spectrum. Copyright © 2014 Elsevier Ltd. All rights reserved.

Optimal output fast feedback in two-time scale control of flexible arms

NASA Technical Reports Server (NTRS)

Siciliano, B.; Calise, A. J.; Jonnalagadda, V. R. P.

1986-01-01

Control of lightweight flexible arms moving along predefined paths can be successfully synthesized on the basis of a two-time scale approach. A model following control can be designed for the reduced order slow subsystem. The fast subsystem is a linear system in which the slow variables act as parameters. The flexible fast variables which model the deflections of the arm along the trajectory can be sensed through strain gage measurements. For full state feedback design the derivatives of the deflections need to be estimated. The main contribution of this work is the design of an output feedback controller which includes a fixed order dynamic compensator, based on a recent convergent numerical algorithm for calculating LQ optimal gains. The design procedure is tested by means of simulation results for the one link flexible arm prototype in the laboratory.

Brain responses in 4-month-old infants are already language specific.

PubMed

Friederici, Angela D; Friedrich, Manuela; Christophe, Anne

2007-07-17

Language is the most important faculty that distinguishes humans from other animals. Infants learn their native language fast and effortlessly during the first years of life, as a function of the linguistic input in their environment. Behavioral studies reported the discrimination of melodic contours [1] and stress patterns [2, 3] in 1-4-month-olds. Behavioral [4, 5] and brain measures [6-8] have shown language-independent discrimination of phonetic contrasts at that age. Language-specific discrimination, however, has been reported for phonetic contrasts only for 6-12-month-olds [9-12]. Here we demonstrate language-specific discrimination of stress patterns in 4-month-old German and French infants by using electrophysiological brain measures. We compare the processing of disyllabic words differing in their rhythmic structure, mimicking German words being stressed on the first syllable, e.g., pápa/daddy[13], and French ones being stressed on the second syllable, e.g., papá/daddy. Event-related brain potentials reveal that experience with German and French differentially affects the brain responses of 4-month-old infants, with each language group displaying a processing advantage for the rhythmic structure typical in its native language. These data indicate language-specific neural representations of word forms in the infant brain as early as 4 months of age.

Motion-Blur-Free High-Speed Video Shooting Using a Resonant Mirror

PubMed Central

Inoue, Michiaki; Gu, Qingyi; Takaki, Takeshi; Ishii, Idaku; Tajima, Kenji

2017-01-01

This study proposes a novel concept of actuator-driven frame-by-frame intermittent tracking for motion-blur-free video shooting of fast-moving objects. The camera frame and shutter timings are controlled for motion blur reduction in synchronization with a free-vibration-type actuator vibrating with a large amplitude at hundreds of hertz so that motion blur can be significantly reduced in free-viewpoint high-frame-rate video shooting for fast-moving objects by deriving the maximum performance of the actuator. We develop a prototype of a motion-blur-free video shooting system by implementing our frame-by-frame intermittent tracking algorithm on a high-speed video camera system with a resonant mirror vibrating at 750 Hz. It can capture 1024 × 1024 images of fast-moving objects at 750 fps with an exposure time of 0.33 ms without motion blur. Several experimental results for fast-moving objects verify that our proposed method can reduce image degradation from motion blur without decreasing the camera exposure time. PMID:29109385

Mr.CAS-A minimalistic (pure) Ruby CAS for fast prototyping and code generation

NASA Astrophysics Data System (ADS)

Ragni, Matteo

There are Computer Algebra System (CAS) systems on the market with complete solutions for manipulation of analytical models. But exporting a model that implements specific algorithms on specific platforms, for target languages or for particular numerical library, is often a rigid procedure that requires manual post-processing. This work presents a Ruby library that exposes core CAS capabilities, i.e. simplification, substitution, evaluation, etc. The library aims at programmers that need to rapidly prototype and generate numerical code for different target languages, while keeping separated mathematical expression from the code generation rules, where best practices for numerical conditioning are implemented. The library is written in pure Ruby language and is compatible with most Ruby interpreters.

An Optical Actuation System and Curvature Sensor for a MR-compatible Active Needle

PubMed Central

Ryu, Seok Chang; Quek, Zhan Fan; Renaud, Pierre; Black, Richard J.; Daniel, Bruce L.; Cutkosky, Mark R.

2015-01-01

A side optical actuation method is presented for a slender MR-compatible active needle. The needle includes an active region with a shape memory alloy (SMA) wire actuator, where the wire generates a contraction force when optically heated by a laser delivered though optical fibers, producing needle tip bending. A prototype, with multiple side heating spots, demonstrates twice as fast an initial response compared to fiber tip heating when 0.8 W of optical power is applied. A single-ended optical sensor with a gold reflector is also presented to measure the curvature as a function of optical transmission loss. Preliminary tests with the sensor prototype demonstrate approximately linear response and a repeatable signal, independent of the bending history. PMID:26509099

Widefield and total internal reflection fluorescent structured illumination microscopy with scanning galvo mirrors

NASA Astrophysics Data System (ADS)

Chen, Youhua; Cao, Ruizhi; Liu, Wenjie; Zhu, Dazhao; Zhang, Zhiming; Kuang, Cuifang; Liu, Xu

2018-04-01

We present an alternative approach to realize structured illumination microscopy (SIM), which is capable for live cell imaging. The prototype utilizes two sets of scanning galvo mirrors, a polarization converter and a piezo-platform to generate a fast shifted, s-polarization interfered and periodic variable illumination patterns. By changing the angle of the scanning galvanometer, we can change the position of the spots at the pupil plane of the objective lens arbitrarily, making it easy to switch between widefield and total internal reflection fluorescent-SIM mode and adapting the penetration depth in the sample. Also, a twofold resolution improvement is achieved in our experiments. The prototype offers more flexibility of pattern period and illumination orientation changing than previous systems.

Measurement of nuclear resonant scattering on 61Ni with fast scintillation detector using proportional-mode silicon avalanche photodiode

NASA Astrophysics Data System (ADS)

Inoue, Keisuke; Kobayashi, Yasuhiro; Yoda, Yoshitaka; Koshimizu, Masanori; Nishikido, Fumihiko; Haruki, Rie; Kishimoto, Shunji

2018-02-01

We developed a new scintillation timing detector using a proportional-mode silicon avalanche photodiode (Si-APD) for synchrotron radiation nuclear resonant scattering. We report on the nuclear forward scattering measurement on 61Ni with a prototype detector using a lead-loaded plastic scintillator (EJ-256, 3 mm in diameter and 2 mm in thickness), mounted on a proportional-mode Si-APD. Using synchrotron X-rays of 67.41 keV, we successfully measured the time spectra of nuclear forward scattering on 61Ni enriched metal foil and 61Ni86V14 alloy. The prototype detector confirmed the expected dynamical beat structure with a time resolution of 0.53 ns (FWHM).

High-speed, multi-channel detector readout electronics for fast radiation detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hennig, Wolfgang

2012-06-22

In this project, we are developing a high speed digital spectrometer that a) captures detector waveforms at rates up to 500 MSPS b) has upgraded event data acquisition with additional data buffers for zero dead time operation c) moves energy calculations to the FPGA to increase spectrometer throughput in fast scintillator applications d) uses a streamlined architecture and high speed data interface for even faster readout to the host PC These features are in addition to the standard functions in our existing spectrometers such as digitization, programmable trigger and energy filters, pileup inspection, data acquisition with energy and time stamps,more » MCA histograms, and run statistics. In Phase I, we upgraded one of our existing spectrometer designs to demonstrate the key principle of fast waveform capture using a 500 MSPS, 12 bit ADC and a Xilinx Virtex-4 FPGA. This upgraded spectrometer, named P500, performed well in initial tests of energy resolution, pulse shape analysis, and timing measurements, thus achieving item (a) above. In Phase II, we are revising the P500 to build a commercial prototype with the improvements listed in items (b)-(d). As described in the previous report, two devices were built to pursue this goal, named the Pixie-500 and the Pixie-500 Express. The Pixie-500 has only minor improvements from the Phase I prototype and is intended as an early commercial product (its production and part of its development were funded outside the SBIR). It also allows testing of the ADC performance in real applications.The Pixie-500 Express (or Pixie-500e) includes all of the improvements (b)-(d). At the end of Phase II of the project, we have tested and debugged the hardware, firmware and software of the Pixie-500 Express prototype boards delivered 12/3/2010. This proved substantially more complex than anticipated. At the time of writing, all hardware bugs have been fixed, the PCI Express interface is working, the SDRAM has been successfully tested and the SHARC DSP has been booted with preliminary code. All new ICs and circuitry on the prototype are working properly, however some of the planned firmware and software functions have not yet been completely implemented and debugged. Overall, due to the unanticipated complexity of the PCI Express interface, some aspects of the project could not be completed with the time and funds available in Phase II. These aspects will be completed in self-funded Phase III.« less

Design and performance of a fast thermal response miniature Chromium Potassium Alum (CPA) salt pill for use in a millikelvin cryocooler

NASA Astrophysics Data System (ADS)

Bartlett, J.; Hardy, G.; Hepburn, I. D.

2015-01-01

The design and performance of a fast thermal response miniature (24 mm outer diameter by 30 mm long) Chromium Potassium Alum (CPA) salt pill is described. The need for a fast thermal response has been driven by the development of a continuously operating millikelvin cryocooler (mKCC) which uses 2 T superconducting magnets that can be ramped to full field in 30 s. The consequence of magnetising and demagnetising the CPA pill in such a short time is that thermal boundary resistance and eddy current heating have a significant impact on the performance of the pill, which was investigated in detail using modelling. The complete design of a prototype CPA pill is described in this paper, including the methods used to minimise thermal boundary resistance and eddy current heating as well as the manufacturing and assembly processes. The performance of the prototype CPA pill operated from a 3.6 K bath is presented, demonstrating that a complete CPA cycle (magnetising, cooling to bath and demagnetising) can be accomplished in under 2.5 min, with magnetisation and demagnetisation taking just 30 s each. The cold finger base temperature of the prototype varies with demagnetisation speed as a consequence of eddy current heating; for a 30 s demagnetisation, a base temperature of 161 mK is obtained, whilst for a 5 min demagnetisation, a base temperature of 149 mK was measured (both from a 3.6 K and 2 T starting position). The measured hold times of the CPA pill at 200 mK, 300 mK, and 1 K are given, proving that the hold time far exceeds the recycle time and demonstrating the potential for continuous operation when two ADRs are used in a tandem configuration. The ease and speed at which the CPA pill temperature can be changed and controlled when stepping between operating temperatures in the range of 200 mK to 4 K using a servo control program is also shown, once again highlighting the excellent thermal response of the pill. All of the test results are in good agreement with the modelling used to design the CPA pill, giving good confidence in our ability to understand and estimate the effects of eddy current heating and thermal boundary resistance. To conclude, the design for the CPA pill to be used in the mKCC (which is heavily based on the design of the prototype) is presented.

Fast Solar Polarimeter: Prototype Characterization and First Results

NASA Astrophysics Data System (ADS)

Iglesias, F. A.; Feller, A.; Krishnappa, N.; Solanki, S. K.

2016-04-01

Due to the differential and non-simultaneous nature of polarization measurements, seeing induced crosstalk (SIC) and seeing limited spatial resolution can easily counterbalance the benefits of solar imaging polarimetry from the ground. The development of instrumental techniques to treat these issues is necessary to fully exploit the next generation of large-aperture solar facilities, and maintain ground-based data at a competitive level with respect to its space-based counterpart. In particular, considering that many open questions in modern solar physics demand data with challenging specifications of resolution and polarimetric sensitivity that can only be achieved with large telescope apertures (Stenflo 1999). Even if state-of-the-art adaptive optics systems greatly improve image quality, their limited correction —due to finite bandwidth, mode number and seeing anisoplanat- ism— produces large residual values of SIC (Krishnappa & Feller 2012). Dual beam polarimeters are commonly used to reduce SIC between the intensity and polarization signals, however, they cannot compensate for the SIC introduced between circular and linear polarization, which can be relevant for high-precision polarimetry. It is known that fast modulation effectively reduces SIC, but the demodulation of the corresponding intensity signals imposes hard requirements on the frame rate of the associated cameras. One way to avoid a fast sensor, is to decouple the camera readout from the intensity demodulation step. This concept is the cornerstone of the very successful Zurich Imaging Polarimeter (ZIMPOL). Even though the ZIMPOL solution allows the detection of very faint signals (˜10-5), its design is not suitable for high-spatial-resolution applications. We are developing a polarimeter that focuses on both spatial resolution (<0.5 arcsec) and polarimetric sensitivity (10-4). The prototype of this Fast Solar Polarimeter (FSP, see Feller et al. 2014), employs a high frame-rate (400 fps), low-noise (<4 e- RMS), pnCCD camera (Hartmann et al. 2006) that is read in synchronization with a polarization modulator based on ferroelectric liquid crystals. The modulator package is similar to the SOLIS (Keller et al. 2003) design and optimized to have an achromatic total polarimetric efficiency above 80 % in the 400-700 nm wavelength range. The fast modulation frequency of FSP, yielding up to 100 full-Stokes measurements per second, and high duty cycle (>95%), have the double benefit of reducing seeing induced artifacts and improving the final spatial resolution by providing an optimal regime for the application of post-facto image reconstruction techniques. In this poster we describe the FSP prototype, including the characterization results, a technique to correct image smearing due to the sensor frame transfer (Iglesias et al. 2015) and some of the first measurements obtained with the 68-cm Vacuum Tower Telescope located at the Observatorio del Teide, Spain.

International Space Station Alpha (ISSA) Integrated Traffic Model

NASA Technical Reports Server (NTRS)

Gates, Robert E.

1994-01-01

The paper discusses the development process of the International Space Station Alpha (ISSA) Integrated Traffic Model which is a subsystem analyses tool utilized in the ISSA design analysis cycles. Fast-track prototyping of the detailed relationships between daily crew and station consumables, propellant needs, maintenance requirements, and crew rotation via spread sheets provides adequate bench marks to assess cargo vehicle design and performance characteristics.

Design Models as Emergent Features: An Empirical Study in Communication and Shared Mental Models in Instructional

ERIC Educational Resources Information Center

Botturi, Luca

2006-01-01

This paper reports the results of an empirical study that investigated the instructional design process of three teams involved in the development of an e-­learning unit. The teams declared they were using the same fast-­prototyping design and development model, and were composed of the same roles (although with a different number of SMEs).…

Neural network architectures to analyze OPAD data

NASA Technical Reports Server (NTRS)

Whitaker, Kevin W.

1992-01-01

A prototype Optical Plume Anomaly Detection (OPAD) system is now installed on the space shuttle main engine (SSME) Technology Test Bed (TTB) at MSFC. The OPAD system requirements dictate the need for fast, efficient data processing techniques. To address this need of the OPAD system, a study was conducted into how artificial neural networks could be used to assist in the analysis of plume spectral data.

Feasibility Analysis and Prototyping of a Fast Autonomous Recon system

DTIC Science & Technology

2017-06-01

Test and Evaluation Interim Contractor Support System Assessment OPERATIONAL USE AND SYSTEM SUPPORT System Operation in the User Environment...Sustaining Maintenance and Logistics Support Operational Testing System Modifications for Improvement Contractor Support System Assessment...helicopter but has the added benefit of high -speed flight similar to a fixed-wing aircraft. Figure 1 shows the two different flight modes of the V-22

Eddy Current Flow Measurements in the FFTF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nielsen, Deborah L.; Polzin, David L.; Omberg, Ronald P.

2017-02-02

The Fast Flux Test Facility (FFTF) is the most recent liquid metal reactor (LMR) to be designed, constructed, and operated by the U.S. Department of Energy (DOE). The 400-MWt sodium-cooled, fast-neutron flux reactor plant was designed for irradiation testing of nuclear reactor fuels and materials for liquid metal fast breeder reactors. Following shut down of the Clinch River Breeder Reactor Plant (CRBRP) project in 1983, FFTF continued to play a key role in providing a test bed for demonstrating performance of advanced fuel designs and demonstrating operation, maintenance, and safety of advanced liquid metal reactors. The FFTF Program provides valuablemore » information for potential follow-on reactor projects in the areas of plant system and component design, component fabrication, fuel design and performance, prototype testing, site construction, and reactor control and operations. This report provides HEDL-TC-1344, “ECFM Flow Measurements in the FFTF Using Phase-Sensitive Detectors”, March 1979.« less

Fast, Deep-Record-Length, Fiber-Coupled Photodiode Imaging Array for Plasma Diagnostics

NASA Astrophysics Data System (ADS)

Brockington, Samuel; Case, Andrew; Witherspoon, F. Douglas

2015-11-01

HyperV Technologies has been developing an imaging diagnostic comprised of an array of fast, low-cost, long-record-length, fiber-optically-coupled photodiode channels to investigate plasma dynamics and other fast, bright events. By coupling an imaging fiber bundle to a bank of amplified photodiode channels, imagers and streak imagers can be constructed. By interfacing analog photodiode systems directly to commercial analog-to-digital converters and modern memory chips, a scalable solution for 100 to 1000 pixel systems with 14 bit resolution and record-lengths of 128k frames has been developed. HyperV is applying these techniques to construct a prototype 1000 Pixel framing camera with up to 100 Msamples/sec rate and 10 to 14 bit depth. Preliminary experimental results as well as future plans will be discussed. Work supported by USDOE Phase 2 SBIR Grant DE-SC0009492.

1st German Phage Symposium—Conference Report

PubMed Central

Huber, Irene; Potapova, Katerina; Kuhn, Andreas; Schmidt, Herbert; Hinrichs, Jörg; Rohde, Christine; Beyer, Wolfgang

2018-01-01

In Germany, phage research and application can be traced back to the beginning of the 20th century. However, with the triumphal march of antibiotics around the world, the significance of bacteriophages faded in most countries, and respective research mainly focused on fundamental questions and niche applications. After a century, we pay tribute to the overuse of antibiotics that led to multidrug resistance and calls for new strategies to combat pathogenic microbes. Against this background, bacteriophages came into the spotlight of researchers and practitioners again resulting in a fast growing “phage community”. In October 2017, part of this community met at the 1st German Phage Symposium to share their knowledge and experiences. The participants discussed open questions and challenges related to phage therapy and the application of phages in general. This report summarizes the presentations given, highlights the main points of the round table discussion and concludes with an outlook for the different aspects of phage application. PMID:29596346

Development and characterization of a dual-energy subtraction imaging system for chest radiography based on CsI:Tl amorphous silicon flat-panel technology

NASA Astrophysics Data System (ADS)

Sabol, John M.; Avinash, Gopal B.; Nicolas, Francois; Claus, Bernhard E. H.; Zhao, Jianguo; Dobbins, James T., III

2001-06-01

Dual-energy subtraction imaging increases the sensitivity and specificity of pulmonary nodule detection in chest radiography by reducing the contrast of overlying bone structures. Recent development of a fast, high-efficiency detector enables dual-energy imaging to be integrated into the traditional workflow. We have modified a GE RevolutionTM XQ/i chest imaging system to construct a dual-energy imaging prototype system. Here we describe the operating characteristics of this prototype and evaluate image quality. Empirical results show that the dual-energy CNR is maximized if the dose is approximately equal for both high and low energy exposures. Given the high detector DQE, and allocation of dose between the two views, we can acquire dual-energy PA and conventional lateral images with total dose equivalent to a conventional two-view film chest exam. Calculations have shown that the dual-exposure technique has superior CNR and tissue cancellation than single-exposure CR systems. Clinical images obtained on a prototype dual-energy imaging system show excellent tissue contrast cancellation, low noise, and modest motion artefacts. In summary, a prototype dual-energy system has been constructed which enables rapid, dual-exposure imaging of the chest using a commercially available high-efficiency, flat-panel x-ray detector. The quality of the clinical images generated with this prototype exceeds that of CR techniques and demonstrates the potential for improved detection and characterization of lung disease through dual-energy imaging.

Peripheral Nerve Stimulation Characteristics of an Asymmetric Head-Only Gradient Coil Compatible with a High-Channel-Count Receiver Array

PubMed Central

Lee, Seung-Kyun; Mathieu, Jean-Baptiste; Graziani, Dominic; Piel, Joseph; Budesheim, Eric; Fiveland, Eric; Hardy, Christopher J.; Tan, Ek Tsoon; Amm, Bruce; Foo, Thomas K.-F; Bernstein, Matt A.; Huston, John; Shu, Yunhong; Schenck, John F.

2015-01-01

Purpose To characterize peripheral nerve stimulation (PNS) of an asymmetric head-only gradient coil that is compatible with a commercial high-channel-count receive-only array. Methods Two prototypes of an asymmetric head-only gradient coil set, with 42-cm inner diameter, were constructed for brain imaging at 3T with maximum performance specifications of up to 85 mT/m and 708 T/m/s. 24 volunteer tests were performed to measure PNS thresholds with the transverse (X, left/right; Y, anterior/posterior) gradient coils of both prototypes. 14 volunteers were also tested for the Z-gradient PNS in the second prototype, and were additionally scanned with high-slew-rate EPI immediately after the PNS tests. Results For both prototypes, the Y-gradient PNS threshold was markedly higher than the X-gradient. The Z-gradient threshold was intermediate between those for the X- and Y-coils. Out of the 24 volunteer subjects, only two experienced Y-gradient PNS at 80 mT/m, 500 T/m/s. All volunteers underwent the EPI scan without PNS when the readout direction was set to A/P. Conclusion Measured PNS characteristics of asymmetric head-only gradient coil prototypes indicate that such coils, especially in the A/P direction, can be used for fast EPI readout in high-performance neuroimaging scans with substantially reduced PNS concerns compared to conventional whole-body gradient coils. PMID:26628078

A Fast and Self-Acting Release-Caging-Mechanism for Actively Driven Drop Tower Systems

NASA Astrophysics Data System (ADS)

Gierse, Andreas; Kaczmarczik, Ulrich; Greif, Andreas; Selig, Hanns; von Kampen, Peter; Könemann, Thorben; Lämmerzahl, Claus

2017-10-01

Today's and future scientific research programs ask for high quality microgravity conditions of 10-6 g on ground combined with high repetition rates of 100 flights per day or more. Accordingly, a new type of drop tower, the GraviTower Bremen, (GTB), has been suggested and is currently under development. As a first stage of development, a GTB-Prototype (GTB-Pro) has been designed which uses an active rope drive to accelerate a slider/drag shield and an experiment therein on a vertical parabola. During the free fall phase, the experiment is decoupled from the slider by a self-acting Release-Caging-Mechanism (RCM). Our prototype will provide 2.5 s of microgravity for experiments of up to 500 kg for at least 100 times per day. In this article, the final concept of the engineering of the active rope drive and the RCM are presented in detail. Based on extensive simulations aiming at an optimization of the whole system we developed a hydraulic rope drive system with minimized vibrational amplitude and low number of eigenfrequencies. The RCM achieves a very fast (≤ 0.1 s) self-acting release of the experiment from the slider by making use of the dynamics of the hydraulic rope drive. Furthermore, passive hydraulic stop dampers in the RCM build a passive and self-acting recoupling mechanism. This system is optimized for a fast decoupling to compensate for the time limitation posed by the chosen drive technology. The simulations included a comparison of different drive technologies, physical effects like the Coriolis force, and the dynamics of the RCM system itself.

Passive cooling and heating program at Oak Ridge National Laboratory for FY-1981

NASA Astrophysics Data System (ADS)

Shapira, H. B.; Kaplan, S. I.; Chester, C. V.

Construction was completed of an earth-sheltered, passively solar heated office-dormitory, the Joint Institute for Heavy Ion Research, designed at ORNL. Instrumentation of the building was designed, procured, and installed. Building performance will be monitored and compared with predictions of the DOE-2 code. A study of the incorporation of vegetation on architecture was conducted by the Harvard School of Design. A final report was issued which is a prototype handbook for the use of vegetation to reduce cooling loads in structures. An experiment to reduce the cooling requirement of mobile homes by shading with fast-growing vines was begun: a maintenance-oriented trellis was constructed and vines were planted. An RFP for the production of a prototype set of reflective insulating blinds was issued.

Determination of authenticity of brand perfume using electronic nose prototypes

NASA Astrophysics Data System (ADS)

Gebicki, Jacek; Szulczynski, Bartosz; Kaminski, Marian

2015-12-01

The paper presents the practical application of an electronic nose technique for fast and efficient discrimination between authentic and fake perfume samples. Two self-built electronic nose prototypes equipped with a set of semiconductor sensors were employed for that purpose. Additionally 10 volunteers took part in the sensory analysis. The following perfumes and their fake counterparts were analysed: Dior—Fahrenheit, Eisenberg—J’ose, YSL—La nuit de L’homme, 7 Loewe and Spice Bomb. The investigations were carried out using the headspace of the aqueous solutions. Data analysis utilized multidimensional techniques: principle component analysis (PCA), linear discrimination analysis (LDA), k-nearest neighbour (k-NN). The results obtained confirmed the legitimacy of the electronic nose technique as an alternative to the sensory analysis as far as the determination of authenticity of perfume is concerned.

Fast Dissemination of New HIV-1 CRF02/A1 Recombinants in Pakistan

PubMed Central

Chen, Yue; Hora, Bhavna; DeMarco, Todd; Shah, Sharaf Ali; Ahmed, Manzoor; Sanchez, Ana M.; Su, Chang; Carter, Meredith; Stone, Mars; Hasan, Rumina; Hasan, Zahra; Busch, Michael P.; Denny, Thomas N.; Gao, Feng

2016-01-01

A number of HIV-1 subtypes are identified in Pakistan by characterization of partial viral gene sequences. Little is known whether new recombinants are generated and how they disseminate since whole genome sequences for these viruses have not been characterized. Near full-length genome (NFLG) sequences were obtained by amplifying two overlapping half genomes or next generation sequencing from 34 HIV-1-infected individuals in Pakistan. Phylogenetic tree analysis showed that the newly characterized sequences were 16 subtype As, one subtype C, and 17 A/G recombinants. Further analysis showed that all 16 subtype A1 sequences (47%), together with the vast majority of sequences from Pakistan from other studies, formed a tight subcluster (A1a) within the subtype A1 clade, suggesting that they were derived from a single introduction. More in-depth analysis of 17 A/G NFLG sequences showed that five shared similar recombination breakpoints as in CRF02 (15%) but were phylogenetically distinct from the prototype CRF02 by forming a tight subcluster (CRF02a) while 12 (38%) were new recombinants between CRF02a and A1a or a divergent A1b viruses. Unique recombination patterns among the majority of the newly characterized recombinants indicated ongoing recombination. Interestingly, recombination breakpoints in these CRF02/A1 recombinants were similar to those in prototype CRF02 viruses, indicating that recombination at these sites more likely generate variable recombinant viruses. The dominance and fast dissemination of new CRF02a/A1 recombinants over prototype CRF02 suggest that these recombinant have more adapted and may become major epidemic strains in Pakistan. PMID:27973597

H4DAQ: a modern and versatile data-acquisition package for calorimeter prototypes test-beams

NASA Astrophysics Data System (ADS)

Marini, A. C.

2018-02-01

The upgrade of the particle detectors for the HL-LHC or for future colliders requires an extensive program of tests to qualify different detector prototypes with dedicated test beams. A common data-acquisition system, H4DAQ, was developed for the H4 test beam line at the North Area of the CERN SPS in 2014 and it has since been adopted in various applications for the CMS experiment and AIDA project. Several calorimeter prototypes and precision timing detectors have used our system from 2014 to 2017. H4DAQ has proven to be a versatile application and has been ported to many other beam test environments. H4DAQ is fast, simple, modular and can be configured to support various kinds of setup. The functionalities of the DAQ core software are split into three configurable finite state machines: data readout, run control, and event builder. The distribution of information and data between the various computers is performed using ZEROMQ (0MQ) sockets. Plugins are available to read different types of hardware, including VME crates with many types of boards, PADE boards, custom front-end boards and beam instrumentation devices. The raw data are saved as ROOT files, using the CERN C++ ROOT libraries. A Graphical User Interface, based on the python gtk libraries, is used to operate the H4DAQ and an integrated data quality monitoring (DQM), written in C++, allows for fast processing of the events for quick feedback to the user. As the 0MQ libraries are also available for the National Instruments LabVIEW program, this environment can easily be integrated within H4DAQ applications.

[Reduced preoperative fasting periods. Current status after a survey of patients and colleagues].

PubMed

Breuer, J-P; Bosse, G; Prochnow, L; Seifert, S; Langelotz, C; Wassilew, G; Francois-Kettner, H; Polze, N; Spies, C

2010-07-01

Since October 2004 German Anaesthesiology Societies have officially recommended a decreased fasting period of 2 h for clear fluids and 6 h for solid food before elective surgery. A survey of patients and health care workers was carried out in our university clinic to assess the implementation of the new fasting recommendations. Surgical patients (n=865) as well as physicians and nurses specialized in anaesthesia and surgery (n=2,355) were invited to complete a written questionnaire. The survey inquired about prescribed and practiced duration of fasting, attitudes towards reduced preoperative fasting and knowledge of the new guidelines. Data from 784 patients (91%) and 557 health care workers (24%) were analysed. Patients reported mean fasting times of 10+/-5 h for fluids and 15+/-4 h for solid food. Of the patients 52% and 16% would have preferred to drink and eat before surgery, respectively and 10% were informed about the new recommendations of shorter preoperative fluid and solid fasting. Such patients reported significantly reduced fasting times for fluids compared with those who were recommended to fast for the traditional longer periods (8+/-6 versus 12+/-4 h, p<0.001). Preoperative fasting advice remembered by the patients significantly differed from the prescribed recommendations (2 h fluid fasting, 22 versus 53%, p<0.001). Anaesthesiologists were significantly more knowledgeable of the new guidelines (90 versus 32-42%, p<0.001) and significantly more willing to recommend the new short preoperative fasting times (75 versus 15-19%, p<0.001) than other health care workers. Of all health care workers 82% and 32% reported patients' frequent desire to drink and eat before surgery, respectively, 92% considered reduced preoperative fasting to be positive, 76% feared increased risks for patients and 42% expected a decreased flexibility in their daily work. The current guidelines for preoperative fasting have not been widely implemented. Besides a knowledge discrepancy, remarkable concerns remain regarding higher risk for patients which may be important barriers to implementation. Nevertheless, health care workers are aware of patients' desire for shorter preoperative fasting. If the new guidelines are recommended patients will make use of them. Further training of staff and adequate implementation tools are needed.

Fast vesicle transport is required for the slow axonal transport of synapsin.

PubMed

Tang, Yong; Scott, David; Das, Utpal; Gitler, Daniel; Ganguly, Archan; Roy, Subhojit

2013-09-25

Although it is known that cytosolic/soluble proteins synthesized in cell bodies are transported at much lower overall velocities than vesicles in fast axonal transport, the fundamental basis for this slow movement is unknown. Recently, we found that cytosolic proteins in axons of mouse cultured neurons are conveyed in a manner that superficially resembles diffusion, but with a slow anterograde bias that is energy- and motor-dependent (Scott et al., 2011). Here we show that slow axonal transport of synapsin, a prototypical member of this rate class, is dependent upon fast vesicle transport. Despite the distinct overall dynamics of slow and fast transport, experimentally induced and intrinsic variations in vesicle transport have analogous effects on slow transport of synapsin as well. Dynamic cotransport of vesicles and synapsin particles is also seen in axons, consistent with a model where higher-order assemblies of synapsin are conveyed by transient and probabilistic associations with vesicles moving in fast axonal transport. We posit that such dynamic associations generate the slow overall anterogradely biased flow of the population ("dynamic-recruitment model"). Our studies uncover the underlying kinetic basis for a classic cytosolic/soluble protein moving in slow axonal transport and reveal previously unknown links between slow and fast transport, offering a clearer conceptual picture of this curious phenomenon.

Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs.

PubMed

Wang, Shu-Yao; A, Ji-Ye; Fei, Fei; Geng, Jian-Liang; Peng, Ying; Ouyang, Bing-Chen; Wang, Pei; Jin, Xiao-Liang; Zhao, Yu-Qing; Wang, Jian-Kun; Geng, Ting; Li, Yan-Jing; Huang, Wen-Zhe; Wang, Zhen-Zhong; Xiao, Wei; Wang, Guang-Ji

2017-10-01

Ginkgo diterpene lactones meglumine injection (GDLI) is a commercially available product used for neuroprotection. However, the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI, i.e., ginkgolide A (GA), ginkgolide B (GB), and ginkgolide K (GK), have never been fully evaluated in beagle dogs. In this work, a simple, sensitive, and reliable method based on ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) was developed, and the prototypes and total amounts of GA, GB, and GK were determined in beagle dog plasma. The plasma concentrations of the hydrolyzed carboxylic forms were calculated by subtracting the prototype concentrations from the total lactone concentrations. For the first time, the pharmacokinetics of GA, GB, and GK were fully assessed in three forms, i.e., the prototypes, the hydrolyzed carboxylic forms, and the total amounts, after intravenous administration of GDLI in beagle dogs. It was shown that ginkgolides primarily existed in the hydrolyzed form in plasma, and the ratio of hydrolysates to prototype forms of GA and GB decreased gradually to a homeostatic ratio. All of the three forms of the three ginkgolides showed linear exposure of AUC to the dosages. GA, GB, and GK showed a constant half-life approximately 2.7, 3.4, and 1.2 h, respectively, which were consistent for the forms at three dose levels (0.3, 1.0, and 3.0 mg·kg -1 ) and after a consecutive injection of GDLI for 7 days (1.0 mg·kg -1 ). Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

[Requirements for a cross-location biobank IT infrastructure : Survey of stakeholder input on the establishment of a biobank network of the German Biobank Alliance (GBA)].

PubMed

Schüttler, C; Buschhüter, N; Döllinger, C; Ebert, L; Hummel, M; Linde, J; Prokosch, H-U; Proynova, R; Lablans, M

2018-04-24

The large number of biobanks within Germany results in a high degree of heterogeneity with regard to the IT components used at the respective locations. Within the German Biobank Alliance (GBA), 13 biobanks implement harmonized processes for the provision of biomaterial and accompanying data. The networking of the individual biobanks and the associated harmonisation of the IT infrastructure should facilitate access to biomaterial and related clinical data. For this purpose, the relevant target groups were first identified in order to determine their requirements for IT solutions to be developed in a workshop. Of the seven identified interest groups, three were initially invited to a first round of discussions. The stakeholder input expressed resulted in a catalogue of requirements with regard to IT support for (i) a sample and data request, (ii) the handling of patient consent and inclusion, and (iii) the subsequent evaluation of the sample and data request. The next step is to design the IT solutions as prototypes based on these requirements. In parallel, further user groups are being surveyed in order to be able to further concretise the specifications for development.

Operational Tsunami Modelling with TsunAWI for the German-Indonesian Tsunami Early Warning System: Recent Developments

NASA Astrophysics Data System (ADS)

Rakowsky, N.; Harig, S.; Androsov, A.; Fuchs, A.; Immerz, A.; Schröter, J.; Hiller, W.

2012-04-01

Starting in 2005, the GITEWS project (German-Indonesian Tsunami Early Warning System) established from scratch a fully operational tsunami warning system at BMKG in Jakarta. Numerical simulations of prototypic tsunami scenarios play a decisive role in a priori risk assessment for coastal regions and in the early warning process itself. Repositories with currently 3470 regional tsunami scenarios for GITEWS and 1780 Indian Ocean wide scenarios in support of Indonesia as a Regional Tsunami Service Provider (RTSP) were computed with the non-linear shallow water modell TsunAWI. It is based on a finite element discretisation, employs unstructured grids with high resolution along the coast and includes inundation. This contribution gives an overview on the model itself, the enhancement of the model physics, and the experiences gained during the process of establishing an operational code suited for thousands of model runs. Technical aspects like computation time, disk space needed for each scenario in the repository, or post processing techniques have a much larger impact than they had in the beginning when TsunAWI started as a research code. Of course, careful testing on artificial benchmarks and real events remains essential, but furthermore, quality control for the large number of scenarios becomes an important issue.

Modelling of an advanced charging system for electric vehicles

NASA Astrophysics Data System (ADS)

Hassan Jaafar, Abdul; Rahman, Ataur; Mohiuddin, A. K. M.; Rashid, Mahbubur

2017-03-01

Climate Change is recognized as one of the greatest environmental problem facing the World today and it has long been appreciated by governments that reducing the impact of the internal combustion (IC) engine powered motor vehicle has an important part to play in addressing this threat. In Malaysia, IC engine powered motor vehicle accounts almost 90% of the national greenhouse gas (GHG) emissions. The need to reduce the emission is paramount, as Malaysia has pledged to reduce 40% of CO2 intensity by 2020 from 2005 level by 25% of improvement in average fuel consumption. The introduction of electric vehicles (EVs) is one of the initiatives. However in terms of percentage, the electric vehicles have not been commonly used by people nowadays and one of the reasons is lack in charging infrastructure especially when cars are on the road. The aim of this study is to simulate and model an advanced charging system for the charging infrastructure of EVs/HEVs all over the nation with slow charging mode with charging current 25 A, medium charging mode with charging current 50 A and fast charging mode with charging current 100 A. The slow charging mode is proposed for residence, medium charging mode for office parking lots, and fast charging mode is called fast charging track for charging station on road. With three modes charger topology, consumers could choose a suitable mode for their car based on their need. The simulation and experiment of advanced charging system has been conducted on a scale down battery pack of nominal voltage of 3.75 V and capacity of 1020 mAh. Result shows that the battery could be charging less than 1 hour with fast charging mode. However, due to limitation of Tenaga Nasional Berhad (TNB) power grid, the maximum 50 A current is considered to be the optimized passive mode for the EV’s battery charging system. The developed advanced charger prototype performance has been compared with the simulation result and conventional charger performance, the maximum variation has been found 15%, this closed agreement between the advanced charger prototype, simulation model and conventional charger validate the prototype model. Furthermore, based on the result presented in this report, the battery to be charged up to 85% of its rated capacity by constant current mode only rather than continue with constant voltage, which could shorten the battery charging time by 16% and prolong the battery life by 10%.

Does obesity lead to a specific lipid disorder? Analysis from the German/Austrian/Swiss APV registry.

PubMed

Holl, Reinhard W; Hoffmeister, Ulrike; Thamm, Michael; Stachow, Rainer; Keller, Klaus-Michael; L'Allemand, Dagmar; Widhalm, Kurt; Flechtner-Mors, Marion; Wiegand, Susanna

2011-09-01

Overweight and obese youth represent a challenge for the affected individual, the healthcare system as well as society as a whole. Increased long-term cardiovascular risk is one of the major consequences of early-onset obesity, affecting both life expectancy and quality of life. The aim of this report is to study the effects of age, gender and obesity category on the presence of individual components of dyslipidemia using normal-weight subjects from the population-based German KIGGS study including 17,641 randomly selected children and adolescents, aged 0-18 years (11,110 normal-weight subjects with lipid measurements) and the German-Austrian-Swiss APV registry, including 57,239 overweight or obese children, adolescents and young adults from 162 specialized obesity care centers (lipid measurements available in 29,711 subjects). Subjects were classified according to BMI category based on the age- and gender-adjusted BMI-z-scores as recommended by the AGA (German Pediatric Obesity working group). Cut-offs for dyslipidemia were based on the recommendations by the American Heart Association: total cholesterol: > 5.2 mmol/l, HDL-cholesterol < 0.9 mmol/l, LDL-cholesterol > 3.4 mmol/l, triglycerides > 1.7 mmol/l. Using SAS 9.2-software, hierarchic modeling with both linear and logistic regression analysis was applied. Within the group of normal-weight children, fasting triglycerides were elevated in 3.3%, LDL-cholesterol in 7.2% and HDL-cholesterol was reduced in 3.1%. With increasing BMI-category, the prevalence of hypertriglyceridemia and reduced HDL-cholesterol increased rapidly. A weaker relationship was present for LDL-cholesterol and total cholesterol. Among obese youth, 30.5% displayed any dyslipidemia, underlining the importance of adequate screening and intervention.

sCMOS detector for imaging VNIR spectrometry

NASA Astrophysics Data System (ADS)

Eckardt, Andreas; Reulke, Ralf; Schwarzer, Horst; Venus, Holger; Neumann, Christian

2013-09-01

The facility Optical Information Systems (OS) at the Robotics and Mechatronics Center of the German Aerospace Center (DLR) has more than 30 years of experience with high-resolution imaging technology. This paper shows the scientific results of the institute of leading edge instruments and focal plane designs for EnMAP VIS/NIR spectrograph. EnMAP (Environmental Mapping and Analysis Program) is one of the selected proposals for the national German Space Program. The EnMAP project includes the technological design of the hyper spectral space borne instrument and the algorithms development of the classification. The EnMAP project is a joint response of German Earth observation research institutions, value-added resellers and the German space industry like Kayser-Threde GmbH (KT) and others to the increasing demand on information about the status of our environment. The Geo Forschungs Zentrum (GFZ) Potsdam is the Principal Investigator of EnMAP. DLR OS and KT were driving the technology of new detectors and the FPA design for this project, new manufacturing accuracy and on-chip processing capability in order to keep pace with the ambitious scientific and user requirements. In combination with the engineering research, the current generations of space borne sensor systems are focusing on VIS/NIR high spectral resolution to meet the requirements on earth and planetary observation systems. The combination of large swath and high spectral resolution with intelligent synchronization control, fast-readout ADC chains and new focal-plane concepts open the door to new remote-sensing and smart deep space instruments. The paper gives an overview over the detector verification program at DLR on FPA level, new control possibilities for sCMOS detectors in global shutter mode and key parameters like PRNU, DSNU, MTF, SNR, Linearity, Spectral Response, Quantum Efficiency, Flatness and Radiation Tolerance will be discussed in detail.

Modeling and simulation of a beam emission spectroscopy diagnostic for the ITER prototype neutral beam injector.

PubMed

Barbisan, M; Zaniol, B; Pasqualotto, R

2014-11-01

A test facility for the development of the neutral beam injection system for ITER is under construction at Consorzio RFX. It will host two experiments: SPIDER, a 100 keV H(-)/D(-) ion RF source, and MITICA, a prototype of the full performance ITER injector (1 MV, 17 MW beam). A set of diagnostics will monitor the operation and allow to optimize the performance of the two prototypes. In particular, beam emission spectroscopy will measure the uniformity and the divergence of the fast particles beam exiting the ion source and travelling through the beam line components. This type of measurement is based on the collection of the Hα/Dα emission resulting from the interaction of the energetic particles with the background gas. A numerical model has been developed to simulate the spectrum of the collected emissions in order to design this diagnostic and to study its performance. The paper describes the model at the base of the simulations and presents the modeled Hα spectra in the case of MITICA experiment.

Recent development on the realization of a 1-inch VSiPMT prototype

NASA Astrophysics Data System (ADS)

Barbato, F. C. T.; Barbarino, G.; Campajola, L.; Di Capua, F.; Mollo, C. M.; Valentini, A.; Vivolo, D.

2017-03-01

The VSiPMT (Vacuum Silicon PhotoMultiplier Tube) is an innovative design for a revolutionary hybrid photodetector. The idea, born with the purpose to use a SiPM for large detection volumes, consists in replacing the classical dynode chain with a SiPM. In this configuration, we match the large sensitive area of a photocathode with the performances of the SiPM technology, which therefore acts like an electron detector and so like a current amplifier. The excellent photon counting capability, fast response, low power consumption and great stability are among the most attractive features of the VSiPMT. In order to realize such a device we first studied the feasibility of this detector both from theoretical and experimental point of view, by implementing a Geant4-based simulation and studying the response of a special non-windowed MPPC by Hamamatsu with an electron beam. Thanks to this result Hamamatsu realized two VSiPMT industrial prototypes with a photocathode of 3mm diameter. We present the progress on the realization of a 1-inch prototype and the preliminary tests we are performing on it.

Electro-Optical Inspection For Tolerance Control As An Integral Part Of A Flexible Machining Cell

NASA Astrophysics Data System (ADS)

Renaud, Blaise

1986-11-01

Institut CERAC has been involved in optical metrology and 3-dimensional surface control for the last couple of years. Among the industrial applications considered is the on-line shape evaluation of machined parts within the manufacturing cell. The specific objective is to measure the machining errors and to compare them with the tolerances set by designers. An electro-optical sensing technique has been developed which relies on a projection Moire contouring optical method. A prototype inspection system has been designed, making use of video detection and computer image processing. Moire interferograms are interpreted, and the metrological information automatically retrieved. A structured database can be generated for subsequent data analysis and for real-time closed-loop corrective actions. A real-time kernel embedded into a synchronisation network (Petri-net) for the control of concurrent processes in the Electra-Optical Inspection (E0I) station was realised and implemented in a MODULA-2 program DIN01. The prototype system for on-line automatic tolerance control taking place within a flexible machining cell is described in this paper, together with the fast-prototype synchronisation program.

First Update of the Criteria for Certification of Chest Pain Units in Germany: Facelift or New Model?

PubMed

Breuckmann, Frank; Rassaf, Tienush

2016-03-01

In an effort to provide a systematic and specific standard-of-care for patients with acute chest pain, the German Cardiac Society introduced criteria for certification of specialized chest pain units (CPUs) in 2008, which have been replaced by a recent update published in 2015. We reviewed the development of CPU establishment in Germany during the past 7 years and compared and commented the current update of the certification criteria. As of October 2015, 228 CPUs in Germany have been successfully certified by the German Cardiac Society; 300 CPUs are needed for full coverage closing gaps in rural regions. Current changes of the criteria mainly affect guideline-adherent adaptions of diagnostic work-ups, therapeutic strategies, risk stratification, in-hospital timing and education, and quality measures, whereas the overall structure remained unchanged. Benchmarking by participation within the German CPU registry is encouraged. Even though the history is short, the concept of certified CPUs in Germany is accepted and successful underlined by its recent implementation in national and international guidelines. First registry data demonstrated a high standard of quality-of-care. The current update provides rational adaptions to new guidelines and developments without raising the level for successful certifications. A periodic release of fast-track updates with shorter time frames and an increase of minimum requirements should be considered.

Suicide on Instagram - Content Analysis of a German Suicide-Related Hashtag.

PubMed

Arendt, Florian

2018-06-21

Suicide is the second leading cause of death among 15-29-year-olds globally. Unfortunately, the suicide-related content on Instagram, a popular social media platform for youth, has not received the scholarly attention it deserves. The present study provides a content analysis of posts tagged as #selbstmord, a German suicide-related hashtag. These posts were created between July 5 and July 11, 2017. Approximately half of all posts included words or visuals related to suicide. Cutting was by far the most prominent method. Although sadness was the dominant emotion, self-hate and loneliness also appeared regularly. Importantly, inconsistency - a gap between one's inner mental state (e.g., sadness) and one's overtly expressed behavior (e.g., smiling) - was also a recurring theme. Conversely, help-seeking, death wishes, and professional awareness-intervention material were very rare. An explorative analysis revealed that some videos relied on very fast cutting techniques. We provide tentative evidence that users may be exposed to purposefully inserted suicide-related subliminal messages (i.e., exposure to content without the user's conscious awareness). We only investigated the content of posts on one German hashtag, and the sample size was rather small. Suicide prevention organizations may consider posting more awareness-intervention materials. Future research should investigate suicide-related subliminal messages in social media video posts. Although tentative, this finding should raise a warning flag for suicide prevention scholars.

Airborne Camera System for Real-Time Applications - Support of a National Civil Protection Exercise

NASA Astrophysics Data System (ADS)

Gstaiger, V.; Romer, H.; Rosenbaum, D.; Henkel, F.

2015-04-01

In the VABENE++ project of the German Aerospace Center (DLR), powerful tools are being developed to aid public authorities and organizations with security responsibilities as well as traffic authorities when dealing with disasters and large public events. One focus lies on the acquisition of high resolution aerial imagery, its fully automatic processing, analysis and near real-time provision to decision makers in emergency situations. For this purpose a camera system was developed to be operated from a helicopter with light-weight processing units and microwave link for fast data transfer. In order to meet end-users' requirements DLR works close together with the German Federal Office of Civil Protection and Disaster Assistance (BBK) within this project. One task of BBK is to establish, maintain and train the German Medical Task Force (MTF), which gets deployed nationwide in case of large-scale disasters. In October 2014, several units of the MTF were deployed for the first time in the framework of a national civil protection exercise in Brandenburg. The VABENE++ team joined the exercise and provided near real-time aerial imagery, videos and derived traffic information to support the direction of the MTF and to identify needs for further improvements and developments. In this contribution the authors introduce the new airborne camera system together with its near real-time processing components and share experiences gained during the national civil protection exercise.

Determination of neutron flux distribution in an Am-Be irradiator using the MCNP.

PubMed

Shtejer-Diaz, K; Zamboni, C B; Zahn, G S; Zevallos-Chávez, J Y

2003-10-01

A neutron irradiator has been assembled at IPEN facilities to perform qualitative-quantitative analysis of many materials using thermal and fast neutrons outside the nuclear reactor premises. To establish the prototype specifications, the neutron flux distribution and the absorbed dose rates were calculated using the MCNP computer code. These theoretical predictions then allow one to discuss the optimum irradiator design and its performance.

Performance Study of the First 2D Prototype of Vertically Integrated Pattern Recognition Associative Memory (VIPRAM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deptuch, Gregory; Hoff, James; Jindariani, Sergo

Extremely fast pattern recognition capabilities are necessary to find and fit billions of tracks at the hardware trigger level produced every second anticipated at high luminosity LHC (HL-LHC) running conditions. Associative Memory (AM) based approaches for fast pattern recognition have been proposed as a potential solution to the tracking trigger. However, at the HL-LHC, there is much less time available and speed performance must be improved over previous systems while maintaining a comparable number of patterns. The Vertically Integrated Pattern Recognition Associative Memory (VIPRAM) Project aims to achieve the target pattern density and performance goal using 3DIC technology. The firstmore » step taken in the VIPRAM work was the development of a 2D prototype (protoVIPRAM00) in which the associative memory building blocks were designed to be compatible with the 3D integration. In this paper, we present the results from extensive performance studies of the protoVIPRAM00 chip in both realistic HL-LHC and extreme conditions. Results indicate that the chip operates at the design frequency of 100 MHz with perfect correctness in realistic conditions and conclude that the building blocks are ready for 3D stacking. We also present performance boundary characterization of the chip under extreme conditions.« less

Integrated Service Provisioning in an Ipv6 over ATM Research Network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eli Dart; Helen Chen; Jerry Friesen

1999-02-01

During the past few years, the worldwide Internet has grown at a phenomenal rate, which has spurred the proposal of innovative network technologies to support the fast, efficient and low-latency transport of a wide spectrum of multimedia traffic types. Existing network infrastructures have been plagued by their inability to provide for real-time application traffic as well as their general lack of resources and resilience to congestion. This work proposes to address these issues by implementing a prototype high-speed network infrastructure consisting of Internet Protocol Version 6 (IPv6) on top of an Asynchronous Transfer Mode (ATM) transport medium. Since ATM ismore » connection-oriented whereas IP uses a connection-less paradigm, the efficient integration of IPv6 over ATM is especially challenging and has generated much interest in the research community. We propose, in collaboration with an industry partner, to implement IPv6 over ATM using a unique approach that integrates IP over fast A TM hardware while still preserving IP's connection-less paradigm. This is achieved by replacing ATM's control software with IP's routing code and by caching IP's forwarding decisions in ATM's VPI/VCI translation tables. Prototype ''VR'' and distributed-parallel-computing applications will also be developed to exercise the realtime capability of our IPv6 over ATM network.« less

Web-based Tsunami Early Warning System with instant Tsunami Propagation Calculations in the GPU Cloud

NASA Astrophysics Data System (ADS)

Hammitzsch, M.; Spazier, J.; Reißland, S.

2014-12-01

Usually, tsunami early warning and mitigation systems (TWS or TEWS) are based on several software components deployed in a client-server based infrastructure. The vast majority of systems importantly include desktop-based clients with a graphical user interface (GUI) for the operators in early warning centers. However, in times of cloud computing and ubiquitous computing the use of concepts and paradigms, introduced by continuously evolving approaches in information and communications technology (ICT), have to be considered even for early warning systems (EWS). Based on the experiences and the knowledge gained in three research projects - 'German Indonesian Tsunami Early Warning System' (GITEWS), 'Distant Early Warning System' (DEWS), and 'Collaborative, Complex, and Critical Decision-Support in Evolving Crises' (TRIDEC) - new technologies are exploited to implement a cloud-based and web-based prototype to open up new prospects for EWS. This prototype, named 'TRIDEC Cloud', merges several complementary external and in-house cloud-based services into one platform for automated background computation with graphics processing units (GPU), for web-mapping of hazard specific geospatial data, and for serving relevant functionality to handle, share, and communicate threat specific information in a collaborative and distributed environment. The prototype in its current version addresses tsunami early warning and mitigation. The integration of GPU accelerated tsunami simulation computations have been an integral part of this prototype to foster early warning with on-demand tsunami predictions based on actual source parameters. However, the platform is meant for researchers around the world to make use of the cloud-based GPU computation to analyze other types of geohazards and natural hazards and react upon the computed situation picture with a web-based GUI in a web browser at remote sites. The current website is an early alpha version for demonstration purposes to give the concept a whirl and to shape science's future. Further functionality, improvements and possible profound changes have to implemented successively based on the users' evolving needs.

Are anticoagulant independent mechanical valves within reach-fast prototype fabrication and in vitro testing of innovative bi-leaflet valve models.

PubMed

Scotten, Lawrence N; Siegel, Rolland

2015-08-01

Exploration for causes of prosthetic valve thrombogenicity has frequently focused on forward or post-closure flow detail. In prior laboratory studies, we uncovered high amplitude flow velocities of short duration close to valve closure implying potential for substantial shear stress with subsequent initiation of blood coagulation pathways. This may be relevant to widely accepted clinical disparity between mechanical and tissue valves vis-à-vis thrombogenicity. With a series of prototype bi-leaflet mechanical valves, we attempt reduction of closure related velocities with the objective of identifying a prototype valve with thrombogenic potential similar to our tissue valve control. This iterative design approach may find application in preclinical assessment of valves for anticoagulation independence. Tested valves included: prototype mechanical bi-leaflet BVs (n=56), controls (n=2) and patented early prototype mechanicals (n=2) from other investigators. Pulsatile and quasi-steady flow systems were used for testing. Projected dynamic valve area (PDVA) was measured using previously described novel technology. Flow velocity over the open and closing periods was determined by volumetric flow rate/PDVA. For the closed valve interval, use was made of data obtained from quasi-steady back pressure/flow tests. Performance was ranked by a proposed thrombogenicity potential index (TPI) relative to tissue and mechanical control valves. Optimization of the prototype valve designs lead to a 3-D printed model (BV3D). For the mitral/aortic site, BV3D has lower TPI (1.10/1.47) relative to the control mechanical valve (3.44/3.93) and similar to the control tissue valve (ideal TPI ≤1.0). Using unique technology, rapid prototyping and thrombogenicity ranking, optimization of experimental valves for reduced thrombogenic potential was expedited and simplified. Innovative mechanical valve configurations were identified that merit consideration for further development which may bring the anti-coagulation independent mechanical valve within reach.

Are anticoagulant independent mechanical valves within reach—fast prototype fabrication and in vitro testing of innovative bi-leaflet valve models

PubMed Central

Siegel, Rolland

2015-01-01

Background Exploration for causes of prosthetic valve thrombogenicity has frequently focused on forward or post-closure flow detail. In prior laboratory studies, we uncovered high amplitude flow velocities of short duration close to valve closure implying potential for substantial shear stress with subsequent initiation of blood coagulation pathways. This may be relevant to widely accepted clinical disparity between mechanical and tissue valves vis-à-vis thrombogenicity. With a series of prototype bi-leaflet mechanical valves, we attempt reduction of closure related velocities with the objective of identifying a prototype valve with thrombogenic potential similar to our tissue valve control. This iterative design approach may find application in preclinical assessment of valves for anticoagulation independence. Methods Tested valves included: prototype mechanical bi-leaflet BVs (n=56), controls (n=2) and patented early prototype mechanicals (n=2) from other investigators. Pulsatile and quasi-steady flow systems were used for testing. Projected dynamic valve area (PDVA) was measured using previously described novel technology. Flow velocity over the open and closing periods was determined by volumetric flow rate/PDVA. For the closed valve interval, use was made of data obtained from quasi-steady back pressure/flow tests. Performance was ranked by a proposed thrombogenicity potential index (TPI) relative to tissue and mechanical control valves. Results Optimization of the prototype valve designs lead to a 3-D printed model (BV3D). For the mitral/aortic site, BV3D has lower TPI (1.10/1.47) relative to the control mechanical valve (3.44/3.93) and similar to the control tissue valve (ideal TPI ≤1.0). Conclusions Using unique technology, rapid prototyping and thrombogenicity ranking, optimization of experimental valves for reduced thrombogenic potential was expedited and simplified. Innovative mechanical valve configurations were identified that merit consideration for further development which may bring the anti-coagulation independent mechanical valve within reach. PMID:26417581

Fast and high resolution thermal detector based on an aluminum nitride piezoelectric microelectromechanical resonator with an integrated suspended heat absorbing element

NASA Astrophysics Data System (ADS)

Hui, Yu; Rinaldi, Matteo

2013-03-01

This letter presents a miniaturized, fast, and high resolution thermal detector, in which a heat absorbing element and a temperature sensitive microelectromechanical system (MEMS) resonator are perfectly overlapped but separated by a microscale air gap. This unique design guarantees efficient and fast (˜10s μs) heat transfer from the absorbing element to the temperature sensitive device and enables high resolution thermal power detection (˜nW), thanks to the low noise performance of the high quality factor (Q = 2305) MEMS resonant thermal detector. A device prototype was fabricated, and its detection capabilities were experimentally characterized. A thermal power as low as 150 nW was experimentally measured, and a noise equivalent power of 6.5 nW/Hz1/2 was extracted. A device thermal time constant of only 350 μs was measured (smallest ever reported for MEMS resonant thermal detectors), indicating the great potential of the proposed technology for the implementation of ultra-fast and high resolution un-cooled resonant thermal detectors.

Borehole prototype for seismic high-resolution exploration

NASA Astrophysics Data System (ADS)

Giese, Rüdiger; Jaksch, Katrin; Krauß, Felix; Krüger, Kay; Groh, Marco; Jurczyk, Andreas

2014-05-01

Target reservoirs for the exploitation of hydrocarbons or hot water for geothermal energy supply can comprise small layered structures, for instance thin layers or faults. The resolution of 2D and 3D surface seismic methods is often not sufficient to determine and locate these structures. Borehole seismic methods like vertical seismic profiling (VSP) and seismic while drilling (SWD) use either receivers or sources within the borehole. Thus, the distance to the target horizon is reduced and higher resolution images of the geological structures can be achieved. Even these methods are limited in their resolution capabilities with increasing target depth. To localize structures more accuracy methods with higher resolution in the range of meters are necessary. The project SPWD -- Seismic Prediction While Drilling aims at s the development of a borehole prototype which combines seismic sources and receivers in one device to improve the seismic resolution. Within SPWD such a prototype has been designed, manufactured and tested. The SPWD-wireline prototype is divided into three main parts. The upper section comprises the electronic unit. The middle section includes the upper receiver, the upper clamping unit as well as the source unit and the lower clamping unit. The lower section consists of the lower receiver unit and the hydraulic unit. The total length of the prototype is nearly seven meters and its weight is about 750 kg. For focusing the seismic waves in predefined directions of the borehole axis the method of phased array is used. The source unit is equipped with four magnetostrictive vibrators. Each can be controlled independently to get a common wave front in the desired direction of exploration. Source signal frequencies up to 5000 Hz are used, which allows resolutions up to one meter. In May and September 2013 field tests with the SPWD-wireline prototype have been carried out at the KTB Deep Crustal Lab in Windischeschenbach (Bavaria). The aim was to proof the pressure-tightness and the functionality of the hydraulic system components of the borehole device. To monitor the prototype four cameras and several moisture sensors were installed along the source and receiver units close to the extendable coupling stamps where an infiltration of fluid is most probably. The tests lasted about 48 hours each. It was possible to extend and to retract the coupling stamps of the prototype up to a depth of 2100 m. No infiltration of borehole fluids in the SPWD-tool was observed. In preparation of the acoustic calibration measurements in the research and education mine of the TU Bergakademie Freiberg seismic sources and receivers as well as the recording electronic devices were installed in the SPWD-wireline prototype at the GFZ. Afterwards, the SPWD-borehole device was transported to the GFZ-Underground-Lab and preliminary test measurements to characterize the radiation pattern characteristics have been carried out in the newly drilled vertical borehole in December 2013. Previous measurements with a laboratory borehole prototype have demonstrated a dependency of the radiated seismic energy from the predefined amplification direction, the wave type and the signal frequencies. SPWD is funded by the German Federal Environment Ministry

WE-D-BRF-04: Experimental Investigations On Ion Radiography with Beam Scanning Using a Range Telescope

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rinaldi, I; Magallanes, L; Ludwig Maximilian University Munich

2014-06-15

Purpose: Ion beams exhibit a finite range and an inverted depth-dose profile, the Bragg peak. These favorable properties allow superior tumordose conformality, but introduce sensitivity to range uncertainties. Hence, imaging techniques play an increasingly important role to support the treatment planning and the in-vivo monitoring of the actual ion beam treatment. Methods: This work presents the experimental investigations carried out to address the feasibility of ion transmission imaging at the Heidelberg Ion Therapy center using an active raster scanning beam delivery system and a prototype range telescope set-up based on a stack of 61 parallel-plate ionization chambers (PPIC) interleaved withmore » 3 mm absorber plates of PMMA. Results: An extensive characterization of the set-up in terms of beam parameters and settings of the read-out electronics was performed and results will be presented. A data processing method to increase the range resolution (MIRR) of the PPIC stack was developed. In this approach, the position of the maximum of the Bragg curve is deduced from the ratio of measured signals in adjacent PPIC channels. MIRR evaluation is based on Bragg curves obtained from Monte Carlo simulations and validated with experimental data acquired with the PPIC stack using ion beams. MIRR was applied to the carbon ion radiography of an anthropomorphic Alderson head phantom yielding a resolution of 0.8 mm water equivalent thickness (WET) compared to the nominal value of 3.495 mm WET given by the thickness of the absorber slabs in the PPIC stack. An absolute comparison of the Alderson phantom carbon ion transmitted image with an X-ray digitally reconstructed radiography, both converted into WET, will also be shown. Conclusion: The obtained results are very promising and motivate further developments of the system towards an eventual clinical use.This work is supported by the German Research Foundation and the German Academic Exchange Service. This work is supported by the German Research Foundation (DFG) and the German Academic Exchange Service (DAAD)« less

Regional differences of glycaemic control in patients with type 2 diabetes mellitus in Switzerland: a national cross-sectional survey.

PubMed

Gerber, Philipp Andreas; Spirk, David; Brändle, Michael; Thoenes, Martin; Lehmann, Roger; Keller, Ulrich

2011-07-07

We investigated contemporary diabetes care, quality of glycaemic control, and progression of obesity in patients with diabetes mellitus in different cultural regions within Switzerland. Overall, 1121 patients treated for type 2 diabetes mellitus by 134 general practitioners were enrolled in this representative, national, cross-sectional survey and were followed retrospectively from the start of diabetes treatment. Patients were classified into four cultural regions; the German, French, Italian and Romansh speaking parts of Switzerland. During 5.5 ± 5.1 years of diabetes treatment (retrospective survey), mean HbA1c decreased from 8.28 ± 2.01% to 7.03 ± 1.24%, fasting glucose decreased from 9.97 ± 3.86 to 7.52 ± 2.23 mmol/l, and BMI decreased from 30.2 ± 5.5 to 29.8 ± 5.6 kg/m² (p <0.001 for all parameters). Insulin therapy was associated with a larger improvement of mean HbA1c (-1.66 ± 2.33% vs. -1.15 ± 1.91%, p = 0.001) and an increase in BMI (+0.36 ± 2.92 vs. -0.63 ± 2.60 kg/m2, p <0.001). At the time when the cross-sectional survey was conducted, the mean HbA1c and fasting glucose were higher in the Italian part compared to other regions (7.72 ± 1.60% and 9.03 ± 2.49 mmol/l, respectively, p <0.001), and lower in the German part (6.89 ± 1.02% and 7.25 ± 2.02 mmol/l, respectively, p <0.001). In comparison to other regions, biguanides were more often used in the French part (86.1% versus 75.7%), insulin secretagogues in the Italian part (69.9% versus 37.8%), thiazolidinediones in the Romansh part (34.1% versus 17.8%), and insulin was more often used in the German part of Switzerland (27.0% versus 17.1%) (p <0.01 for all parameters). Efforts to identify regional-cultural differences and attempts to overcome associated potential barriers should be emphasised in any health care system when aiming for better diabetic patient care.

Proposed fast-response oxygen monitoring and control system for the Langley 8-foot high-temperature tunnel

NASA Technical Reports Server (NTRS)

Singh, J. J.; Davis, W. T.; Puster, R. L.

1983-01-01

A fast-response oxygen monitoring and control system, based on a Y2O3-stabilized ZrO2 sensor, was developed and tested in the laboratory. The system is capable of maintaining oxygen concentration in the CH4-O2-air combustion product gases at 20.9 + or - 1.0 percent. If the oxygen concentration in the exhaust stream differs from that in normal air by 25 percent or more, an alarm signal is provided for automatic tunnel shutdown. The overall prototype system response time was reduced from about 1 sec in the original configuration to about 0.2 sec. The basis of operation and the results of laboratory tests of the system are described.

A neutron camera system for MAST.

PubMed

Cecconello, M; Turnyanskiy, M; Conroy, S; Ericsson, G; Ronchi, E; Sangaroon, S; Akers, R; Fitzgerald, I; Cullen, A; Weiszflog, M

2010-10-01

A prototype neutron camera has been developed and installed at MAST as part of a feasibility study for a multichord neutron camera system with the aim to measure the spatial and time resolved 2.45 MeV neutron emissivity profile. Liquid scintillators coupled to a fast digitizer are used for neutron/gamma ray digital pulse shape discrimination. The preliminary results obtained clearly show the capability of this diagnostic to measure neutron emissivity profiles with sufficient time resolution to study the effect of fast ion loss and redistribution due to magnetohydrodynamic activity. A minimum time resolution of 2 ms has been achieved with a modest 1.5 MW of neutral beam injection heating with a measured neutron count rate of a few 100 kHz.

Posttest analysis of international standard problem 10 using RELAP4/MOD7. [PWR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hsu, M.; Davis, C.B.; Peterson, A.C. Jr.

RELAP4/MOD7, a best estimate computer code for the calculation of thermal and hydraulic phenomena in a nuclear reactor or related system, is the latest version in the RELAP4 code development series. This paper evaluates the capability of RELAP4/MOD7 to calculate refill/reflood phenomena. This evaluation uses the data of International Standard Problem 10, which is based on West Germany's KWU PKL refill/reflood experiment K9A. The PKL test facility represents a typical West German four-loop, 1300 MW pressurized water reactor (PWR) in reduced scale while maintaining prototypical volume-to-power ratio. The PKL facility was designed to specifically simulate the refill/reflood phase of amore » hypothetical loss-of-coolant accident (LOCA).« less

A microcomputer based frequency-domain processor for laser Doppler anemometry

NASA Technical Reports Server (NTRS)

Horne, W. Clifton; Adair, Desmond

1988-01-01

A prototype multi-channel laser Doppler anemometry (LDA) processor was assembled using a wideband transient recorder and a microcomputer with an array processor for fast Fourier transform (FFT) computations. The prototype instrument was used to acquire, process, and record signals from a three-component wind tunnel LDA system subject to various conditions of noise and flow turbulence. The recorded data was used to evaluate the effectiveness of burst acceptance criteria, processing algorithms, and selection of processing parameters such as record length. The recorded signals were also used to obtain comparative estimates of signal-to-noise ratio between time-domain and frequency-domain signal detection schemes. These comparisons show that the FFT processing scheme allows accurate processing of signals for which the signal-to-noise ratio is 10 to 15 dB less than is practical using counter processors.

MIDAS, prototype Multivariate Interactive Digital Analysis System, phase 1. Volume 1: System description

NASA Technical Reports Server (NTRS)

Kriegler, F. J.

1974-01-01

The MIDAS System is described as a third-generation fast multispectral recognition system able to keep pace with the large quantity and high rates of data acquisition from present and projected sensors. A principal objective of the MIDAS program is to provide a system well interfaced with the human operator and thus to obtain large overall reductions in turnaround time and significant gains in throughput. The hardware and software are described. The system contains a mini-computer to control the various high-speed processing elements in the data path, and a classifier which implements an all-digital prototype multivariate-Gaussian maximum likelihood decision algorithm operating at 200,000 pixels/sec. Sufficient hardware was developed to perform signature extraction from computer-compatible tapes, compute classifier coefficients, control the classifier operation, and diagnose operation.

A Compact and Low Cost Electronic Nose for Aroma Detection

PubMed Central

Macías, Miguel Macías; Agudo, J. Enrique; Manso, Antonio García; Orellana, Carlos Javier García; Velasco, Horacio Manuel González; Caballero, Ramón Gallardo

2013-01-01

This article explains the development of a prototype of a portable and a very low-cost electronic nose based on an mbed microcontroller. Mbeds are a series of ARM microcontroller development boards designed for fast, flexible and rapid prototyping. The electronic nose is comprised of an mbed, an LCD display, two small pumps, two electro-valves and a sensor chamber with four TGS Figaro gas sensors. The performance of the electronic nose has been tested by measuring the ethanol content of wine synthetic matrices and special attention has been paid to the reproducibility and repeatability of the measurements taken on different days. Results show that the electronic nose with a neural network classifier is able to discriminate wine samples with 10, 12 and 14% V/V alcohol content with a classification error of less than 1%. PMID:23698265

Passive cooling and heating program at Oak Ridge National Laboratory for FY-1981

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shapira, H.B.; Kaplan, S.I.; Chester, C.V.

1981-01-01

Construction was completed of an earth-sheltered, passively solar heated office-dormitory, the Joint Institute for Heavy Ion Research, designed at ORNL. Instrumentation of the building was designed, procured, and installed. Building performance will be monitored and compared with predictions of the DOE-2 code. A study of the incorporation of vegetation on architecture was conducted by the Harvard School of Design. A final report was issued which is a prototype handbook for the use of vegetation to reduce cooling loads in structures. An experiment to reduce the cooling requirement of mobile homes by shading with fast-growing vines was begun: a maintenance-oriented trellismore » was constructed and vines were planted. An RFP for the production of a prototype set of reflective insulating blinds was issued.« less

Test beam measurement of the first prototype of the fast silicon pixel monolithic detector for the TT-PET project

NASA Astrophysics Data System (ADS)

Paolozzi, L.; Bandi, Y.; Benoit, M.; Cardarelli, R.; Débieux, S.; Forshaw, D.; Hayakawa, D.; Iacobucci, G.; Kaynak, M.; Miucci, A.; Nessi, M.; Ratib, O.; Ripiccini, E.; Rücker, H.; Valerio, P.; Weber, M.

2018-04-01

The TT-PET collaboration is developing a PET scanner for small animals with 30 ps time-of-flight resolution and sub-millimetre 3D detection granularity. The sensitive element of the scanner is a monolithic silicon pixel detector based on state-of-the-art SiGe BiCMOS technology. The first ASIC prototype for the TT-PET was produced and tested in the laboratory and with minimum ionizing particles. The electronics exhibit an equivalent noise charge below 600 e‑ RMS and a pulse rise time of less than 2 ns , in accordance with the simulations. The pixels with a capacitance of 0.8 pF were measured to have a detection efficiency greater than 99% and, although in the absence of the post-processing, a time resolution of approximately 200 ps .

CCD developments for particle colliders

NASA Astrophysics Data System (ADS)

Stefanov, Konstantin D.

2006-09-01

Charge Coupled Devices (CCDs) have been successfully used in several high-energy physics experiments over the last 20 years. Their small pixel size and excellent precision provide superb tool for studying of short-lived particles and understanding the nature at fundamental level. Over the last years the Linear Collider Flavour Identification (LCFI) collaboration has developed Column-Parallel CCDs (CPCCD) and CMOS readout chips to be used for the vertex detector at the International Linear Collider (ILC). The CPCCDs are very fast devices capable of satisfying the challenging requirements imposed by the beam structure of the superconducting accelerator. First set of prototype devices have been designed, manufactured and successfully tested, with second-generation chips on the way. Another idea for CCD-based device, the In-situ Storage Image Sensor (ISIS) is also under development and the first prototype is in production.

CCD-based vertex detector for ILC

NASA Astrophysics Data System (ADS)

Stefanov, Konstantin D.

2006-12-01

Charge Coupled Devices (CCDs) have been successfully used in several high-energy physics experiments over the last 20 years. Their small pixel size and excellent precision provide a superb tool for studying of short-lived particles and understanding the nature at fundamental level. Over the last few years the Linear Collider Flavour Identification (LCFI) collaboration has developed Column-Parallel CCDs (CPCCD) and CMOS readout chips, to be used for the vertex detector at the International Linear Collider (ILC). The CPCCDs are very fast devices capable of satisfying the challenging requirements imposed by the beam structure of the superconducting accelerator. The first set of prototype devices have been successfully designed, manufactured and tested, with second generation chips on the way. Another idea for CCD-based device, the In-situ Storage Image Sensor (ISIS) is also under development and the first prototype has been manufactured.

[The Referral Field Hospital of the Emergency Response Unit (ERU) of the German Red Cross].

PubMed

Schnabel, M; Munz, R; Bohe, M

2000-07-14

Emergency Response units (ERUs) have been developed as a part of the International Federation of Red Cross and Red Crescent Societies strategy to provide fast and effective medical and technical help to victims of disasters of any kind. ERUs provide timely, professional and organised response in a standardised and streamlined way by a balanced composition of professional staff and predesigned equipment. The German Red Cross ERUs "Referral Hospital" and "Specialised Water" took part in the world wide humanitarian help for refugees during the Kosovo war and actually for earthquake victims in Turkey. During the Kosovo-operation the ERU "Referral Hospital" and "Specialised Water" were situated in Macedonia close to the kosovarian boarder at refugee camp Stenkovec I. The Field-Hospital was responsible for all kind of medical emergencies, for a total number of more than 50,000 refugees. During the mission 6225 patients were treated in our Out Patient Department; 541 were hospitalised. Among those 102 medium and major surgical procedures and 105 deliveries were performed. Surprisingly there was no increased rate of infections or perinatal deaths. During the Kosovo war and actually in Turkey the ERU concept prove itself to be a powerful strategy to provide fast needed medical help to victims of different kind of disasters. Humanitarian work in situations of war, internal disorder and various states of emergency in foreign countries and cultures demand flexibility and the ability to improvise while working under such conditions. The confrontation with non-combatants injured by buried landmines is underlining the growing world-wide demand for a total ban on these vile weapons.

Broadcast of four HD videos with LED ceiling lighting: optical-wireless MAC

NASA Astrophysics Data System (ADS)

Bouchet, Olivier; Porcon, Pascal; Gueutier, Eric

2011-09-01

The European project "hOME Gigabit Access Network" (OMEGA) targeted various wireless and wired solutions for 1 Gbit/s connectivity in Home Area Networks (HANs). One objective was to evaluate the suitability of optical wireless technologies in two spectral regions: visible light (visible-light communications - VLC) and near infrared (infrared communications - IRC). Several demonstrators have been built, all of them largely relying on overthe- shelf components. The demonstrators included a "wide-area" VLC broadcast link based on LED ceiling lighting and a laser-based high-data-rate "wide-area" IRC prototype. In this paper we discuss an adapted optical-wireless media-access-control (OWMAC) sublayer, which was developed and implemented during the project. It is suitable for both IRC and VLC. The VLC prototype is based on DMT signal processing and provides broadcasting at { 100 Mbit/s over an area of approximately 5 m2. The IRC prototype provides {300 Mbit/s half-duplex communication over an area of approximately 30 m2. The IRC mesh network, composed of one base station and two terminals, is based on OOK modulation, multi-sector transceivers, and an ultra-fast sector switch. After a brief discussion about the design of the optical-wireless data link layer and the optical-wireless switch (OWS) card, we address the card development and implementation. We also present applications for the VLC and IRC prototypes and measurement results regarding the MAC layer.

Lessons Learned about Liquid Metal Reactors from FFTF Experience

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wootan, David W.; Casella, Andrew M.; Omberg, Ronald P.

2016-09-20

The Fast Flux Test Facility (FFTF) is the most recent liquid-metal reactor (LMR) to operate in the United States, from 1982 to 1992. FFTF is located on the DOE Hanford Site near Richland, Washington. The 400-MWt sodium-cooled, low-pressure, high-temperature, fast-neutron flux, nuclear fission test reactor was designed specifically to irradiate Liquid Metal Fast Breeder Reactor (LMFBR) fuel and components in prototypical temperature and flux conditions. FFTF played a key role in LMFBR development and testing activities. The reactor provided extensive capability for in-core irradiation testing, including eight core positions that could be used with independent instrumentation for the test specimens.more » In addition to irradiation testing capabilities, FFTF provided long-term testing and evaluation of plant components and systems for LMFBRs. The FFTF was highly successful and demonstrated outstanding performance during its nearly 10 years of operation. The technology employed in designing and constructing this reactor, as well as information obtained from tests conducted during its operation, can significantly influence the development of new advanced reactor designs in the areas of plant system and component design, component fabrication, fuel design and performance, prototype testing, site construction, and reactor operations. The FFTF complex included the reactor, as well as equipment and structures for heat removal, containment, core component handling and examination, instrumentation and control, and for supplying utilities and other essential services. The FFTF Plant was designed using a “system” concept. All drawings, specifications and other engineering documentation were organized by these systems. Efforts have been made to preserve important lessons learned during the nearly 10 years of reactor operation. A brief summary of Lessons Learned in the following areas will be discussed: Acceptance and Startup Testing of FFTF FFTF Cycle Reports« less

Histostitcher™: An informatics software platform for reconstructing whole-mount prostate histology using the extensible imaging platform framework

PubMed Central

Toth, Robert J.; Shih, Natalie; Tomaszewski, John E.; Feldman, Michael D.; Kutter, Oliver; Yu, Daphne N.; Paulus, John C.; Paladini, Ginaluca; Madabhushi, Anant

2014-01-01

Context: Co-registration of ex-vivo histologic images with pre-operative imaging (e.g., magnetic resonance imaging [MRI]) can be used to align and map disease extent, and to identify quantitative imaging signatures. However, ex-vivo histology images are frequently sectioned into quarters prior to imaging. Aims: This work presents Histostitcher™, a software system designed to create a pseudo whole mount histology section (WMHS) from a stitching of four individual histology quadrant images. Materials and Methods: Histostitcher™ uses user-identified fiducials on the boundary of two quadrants to stitch such quadrants. An original prototype of Histostitcher™ was designed using the Matlab programming languages. However, clinical use was limited due to slow performance, computer memory constraints and an inefficient workflow. The latest version was created using the extensible imaging platform (XIP™) architecture in the C++ programming language. A fast, graphics processor unit renderer was designed to intelligently cache the visible parts of the histology quadrants and the workflow was significantly improved to allow modifying existing fiducials, fast transformations of the quadrants and saving/loading sessions. Results: The new stitching platform yielded significantly more efficient workflow and reconstruction than the previous prototype. It was tested on a traditional desktop computer, a Windows 8 Surface Pro table device and a 27 inch multi-touch display, with little performance difference between the different devices. Conclusions: Histostitcher™ is a fast, efficient framework for reconstructing pseudo WMHS from individually imaged quadrants. The highly modular XIP™ framework was used to develop an intuitive interface and future work will entail mapping the disease extent from the pseudo WMHS onto pre-operative MRI. PMID:24843820

Alien or Alike? How the Perceived Similarity Between the Typical Science Teacher and a Student's Self-Image Correlates with Choosing Science at School

NASA Astrophysics Data System (ADS)

Kessels, Ursula; Taconis, Ruurd

2012-12-01

By applying the self-to-prototype matching theory to students' academic choices, this study links the unpopularity of science in many industrialized countries with the perceived gap between typical persons representing science (e.g. physics teachers) on the one hand and students' self-image on the other. A sample of N = 308 Dutch and German students described both themselves and typical teachers representing different school subjects using 65 trait adjectives. The following hypotheses were tested: The typical hard sciences teacher and the typical languages teacher will be perceived as differing in their personal characteristics. The typical physics teachers will be perceived as being less similar to students' own self-image than teachers representing languages. Actual choices students make during secondary school should correlate with the perceived fit between students' self-image and the prototype of teachers representing different school subjects, especially in the less frequent and less popular choices of a math or physics major/profile. The findings supported these hypotheses. The discussion stresses that students acquire not only knowledge about science but also about science culture (sensu Aikenhead) in their science classes and that students' image of science teachers can influence their academic choices.

Seasonal and Interannual Fast-Ice Variability from MODIS Surface-Temperature Anomalies, and its Link to External Forcings in Atka Bay, Antarctica

NASA Astrophysics Data System (ADS)

Paul, S.; Hoppmann, M.; Willmes, S.; Heinemann, G.

2016-12-01

Around Antarctica, sea ice is regularly attached to coastal features. These regions of mostly seasonal fast ice interact with the atmosphere, ocean and coastal ecosystem in a variety of ways. The growth and breakup cycles may depend on different factors, such as water- and air temperatures, wind conditions, tides, ocean swell, the passage of icebergs and the presence of nearby polynyas. However, a detailed understanding about the interaction between these factors and the fast-ice cycle is missing. In order to better understand the linkages between general fast-ice evolution and external forcing factors, we present results from an observational case study performed on the seasonal fast-ice cover of Atka Bay, eastern Weddell Sea. The ice conditions in this region are critical for the supply of the German wintering station Neumayer III. Moreover, the fast ice at Atka Bay hosts a unique ecosystem based on the presence of a sub-ice platelet layer and a large emperor penguin colony. While some qualitative characterizations on the seasonal fast-ice cycle in this region exist, no proper quantification was carried out to date. The backbone of this work is a new algorithm, which yields the first continuous time series of open-water fractions from Moderate-Resolution Imaging Spectroradiometer (MODIS) surface temperatures. The open-water fractions are derived from a range of running multi-day median temperature composites, utilizing the thermal footprint of warm open water and thin ice in contrast to cold pack-ice/ice-shelf areas. This unique, and manually validated dataset allows us to monitor changes in fast-ice extent on a near daily basis, for a period of 14 years (2002-2015). In a second step, we combine these results with iceberg observations, data from the meteorological observatory, and auxiliary satellite data in order to identify the main factors governing fast-ice formation and break-up.

MONDO: A tracker for the characterization of secondary fast and ultrafast neutrons emitted in particle therapy

NASA Astrophysics Data System (ADS)

Mirabelli, R.; Battistoni, G.; Giacometti, V.; Patera, V.; Pinci, D.; Sarti, A.; Sciubba, A.; Traini, G.; Marafini, M.

2018-01-01

In Particle Therapy (PT) accelerated charged particles and light ions are used for treating tumors. One of the main limitation to the precision of PT is the emission of secondary particles due to the beam interaction with the patient: secondary emitted neutrons can release a significant dose far from the tumor. Therefore, a precise characterization of their flux, production energy and angle distribution is eagerly needed in order to improve the Treatment Planning Systems (TPS) codes. The principal aim of the MONDO (MOnitor for Neutron Dose in hadrOntherapy) project is the development of a tracking device optimized for the detection of fast and ultra-fast secondary neutrons emitted in PT. The detector consists of a matrix of scintillating square fibres coupled with a CMOS-based readout. Here, we present the characterization of the detector tracker prototype and CMOS-based digital SPAD (Single Photon Avalanche Diode) array sensor tested with protons at the Beam Test Facility (Frascati, Italy) and at the Proton Therapy Centre (Trento, Italy), respectively.

The method for on-site determination of trace concentrations of methyl mercaptan and dimethyl sulfide in air using a mobile mass spectrometer with atmospheric pressure chemical ionization, combined with a fast enrichment/separation system.

PubMed

Kudryavtsev, Andrey S; Makas, Alexey L; Troshkov, Mikhail L; Grachev, Mikhail А; Pod'yachev, Sergey P

2014-06-01

A method for fast simultaneous on-site determination of methyl mercaptan and dimethyl sulfide in air was developed. The target compounds were actively collected on silica gel, followed by direct flash thermal desorption, fast separation on a short chromatographic column and detection by means of mass spectrometer with atmospheric pressure chemical ionization. During the sampling of ambient air, water vapor was removed with a Nafion selective membrane. A compact mass spectrometer prototype, which was designed earlier at Trofimuk Institute of Petroleum Geology and Geophysics, was used. The minimization of gas load of the atmospheric pressure ion source allowed reducing the power requirements and size of the vacuum system and increasing its ruggedness. The measurement cycle is about 3 min. Detection limits in a 0.6 L sample are 1 ppb for methyl mercaptan and 0.2 ppb for dimethyl sulfide. Copyright © 2014 Elsevier B.V. All rights reserved.

Production of hydrogen from biomass by catalytic steam reforming of fast pyrolysis oil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Czernik, S.; Wang, D.; Chornet, E.

1998-08-01

Hydrogen is the prototype of the environmentally cleanest fuel of interest for power generation using fuel cells and for transportation. The thermochemical conversion of biomass to hydrogen can be carried out through two distinct strategies: (a) gasification followed by water-gas shift conversion, and (b) catalytic steam reforming of specific fractions derived from fast pyrolysis and aqueous/steam processes of biomass. This paper presents the latter route that begins with fast pyrolysis of biomass to produce bio-oil. This oil (as a whole or its selected fractions) can be converted to hydrogen via catalytic steam reforming followed by a water-gas shift conversion step.more » Such a process has been demonstrated at the bench scale using model compounds, poplar oil aqueous fraction, and the whole pyrolysis oil with commercial Ni-based steam reforming catalysts. Hydrogen yields as high as 85% have been obtained. Catalyst initial activity can be recovered through regeneration cycles by steam or CO{sub 2} gasification of carbonaceous deposits.« less

Neutron Detection With Ultra-Fast Digitizer and Pulse Identification Techniques on DIII-D

NASA Astrophysics Data System (ADS)

Zhu, Y. B.; Heidbrink, W. W.; Piglowski, D. A.

2013-10-01

A prototype system for neutron detection with an ultra-fast digitizer and pulse identification techniques has been implemented on the DIII-D tokamak. The system consists of a cylindrical neutron fission chamber, a charge sensitive amplifier, and a GaGe Octopus 12-bit CompuScope digitizer card installed in a Linux computer. Digital pulse identification techniques have been successfully performed at maximum data acquisition rate of 50 MSPS with on-board memory of 2 GS. Compared to the traditional approach with fast nuclear electronics for pulse counting, this straightforward digital solution has many advantages, including reduced expense, improved accuracy, higher counting rate, and easier maintenance. The system also provides the capability of neutron-gamma pulse shape discrimination and pulse height analysis. Plans for the upgrade of the old DIII-D neutron counting system with these techniques will be presented. Work supported by the US Department of Energy under SC-G903402, and DE-FC02-04ER54698.

Daily commuting to work is not associated with variables of health.

PubMed

Mauss, Daniel; Jarczok, Marc N; Fischer, Joachim E

2016-01-01

Commuting to work is thought to have a negative impact on employee health. We tested the association of work commute and different variables of health in German industrial employees. Self-rated variables of an industrial cohort (n = 3805; 78.9 % male) including absenteeism, presenteeism and indices reflecting stress and well-being were assessed by a questionnaire. Fasting blood samples, heart-rate variability and anthropometric data were collected. Commuting was grouped into one of four categories: 0-19.9, 20-44.9, 45-59.9, ≥60 min travelling one way to work. Bivariate associations between commuting and all variables under study were calculated. Linear regression models tested this association further, controlling for potential confounders. Commuting was positively correlated with waist circumference and inversely with triglycerides. These associations did not remain statistically significant in linear regression models controlling for age, gender, marital status, and shiftwork. No other association with variables of physical, psychological, or mental health and well-being could be found. The results indicate that commuting to work has no significant impact on well-being and health of German industrial employees.

[Waiting for the EuGH verdict to be put into practice or "Introduction of the four-day week on full pay"].

PubMed

Langwara, H; Laier, P; Hecht, R

2002-10-01

The submitted model of working time transposes and interprets german industrial law. The result of this interpretation is a high level of acceptance of the employees, a fast education that is high qualified with costs that are still affordable. The advantage of this model compared with the shift-model that runs after the EuGH-decision is obvious if you look at the reality of our health care system. This is why it is important to have an efficient interpretation of the existing law. Of course it will be a necessity also in the future to create new models of working time and to adapt these models in a way that it fits into the structure of a hospital. It would be the wrong way to force a juridical and political decision, how it was done by the german government that gave a deadline to put the EuGH decision into operation, without the possibility of an interpretation that fulfils the demand of the hospital.

Influence of long-term altered gravity on the swimming performance of developing cichlid fish: including results from the 2nd German Spacelab Mission D-2

NASA Astrophysics Data System (ADS)

Rahmann, H.; Hilbig, R.; Flemming, J.; Slenzka, K.

This study presents qualitative and quantitative data concerning gravity-dependent changes in the swimming behaviour of developing cichlid fish larvae (Oreochromis mossambicus) after a 9 resp. 10 days exposure to increased acceleration (centrifuge experiments), to reduced gravity (fast-rotating clinostat), changed accelerations (parabolic air craft flights) and to near weightlessness (2nd German Spacelab Mission D-2). Changes of gravity initially cause disturbances of the swimming performance of the fish larvae. With prolonged stay in orbit a step by step normalisation of the swimming behaviour took place in the fish. After return to 1g earth conditions no somersaulting or looping could be detected concerning the fish, but still slow and disorientated movements as compared to controls occurred. The fish larvae adapted to earth gravity within 3-5 days. Fish seem to be in a distinct early developmental stages extreme sensitive and adaptable to altered gravity. However, elder fish either do not react or show compensatory behaviour e.g. escape reactions.

Fast and slow readers of the Hebrew language show divergence in brain response ∼200 ms post stimulus: an ERP study.

PubMed

Korinth, Sebastian Peter; Breznitz, Zvia

2014-01-01

Higher N170 amplitudes to words and to faces were recently reported for faster readers of German. Since the shallow German orthography allows phonological recoding of single letters, the reported speed advantages might have their origin in especially well-developed visual processing skills of faster readers. In contrast to German, adult readers of Hebrew are forced to process letter chunks up to whole words. This dependence on more complex visual processing might have created ceiling effects for this skill. Therefore, the current study examined whether also in the deep Hebrew orthography visual processing skills as reflected by N170 amplitudes explain reading speed differences. Forty university students, native speakers of Hebrew without reading impairments, accomplished a lexical decision task (i.e., deciding whether a visually presented stimulus represents a real or a pseudo word) and a face decision task (i.e., deciding whether a face was presented complete or with missing facial features) while their electroencephalogram was recorded from 64 scalp positions. In both tasks stronger event related potentials (ERPs) were observed for faster readers in time windows at about 200 ms. Unlike in previous studies, ERP waveforms in relevant time windows did not correspond to N170 scalp topographies. The results support the notion of visual processing ability as an orthography independent marker of reading proficiency, which advances our understanding about regular and impaired reading development.

Modeling and simulation of a beam emission spectroscopy diagnostic for the ITER prototype neutral beam injector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barbisan, M., E-mail: marco.barbisan@igi.cnr.it; Zaniol, B.; Pasqualotto, R.

2014-11-15

A test facility for the development of the neutral beam injection system for ITER is under construction at Consorzio RFX. It will host two experiments: SPIDER, a 100 keV H{sup −}/D{sup −} ion RF source, and MITICA, a prototype of the full performance ITER injector (1 MV, 17 MW beam). A set of diagnostics will monitor the operation and allow to optimize the performance of the two prototypes. In particular, beam emission spectroscopy will measure the uniformity and the divergence of the fast particles beam exiting the ion source and travelling through the beam line components. This type of measurementmore » is based on the collection of the H{sub α}/D{sub α} emission resulting from the interaction of the energetic particles with the background gas. A numerical model has been developed to simulate the spectrum of the collected emissions in order to design this diagnostic and to study its performance. The paper describes the model at the base of the simulations and presents the modeled H{sub α} spectra in the case of MITICA experiment.« less

Innovation-Prototype. Making hydraulic and/or pneumatic plates using 3D printing technology

NASA Astrophysics Data System (ADS)

Alexa, V.; Rațiu, S. A.; Kiss, I.; Cioată, V. G.; Rackov, M.

2018-01-01

Start 3D printing allows hydraulic and/or pneumatic plates to be obtained from a single technological process without requiring further post-production operations. 3D printing with innovative materials in a rich colour range has several advantages such as: time-saving, cost is the same for any type of plate and its reported just to volume, fast and impossible realization of hydraulic and/or pneumatic links compared to traditional and high accuracy technologies.

Search for GRB related prompt optical emission and other fast varying objects with ``Pi of the Sky'' detector

NASA Astrophysics Data System (ADS)

Ćwiok, M.; Dominik, W.; Małek, K.; Mankiewicz, L.; Mrowca-Ciułacz, J.; Nawrocki, K.; Piotrowski, L. W.; Sitek, P.; Sokołowski, M.; Wrochna, G.; Żarnecki, A. F.

2007-06-01

Experiment “Pi of the Sky” is designed to search for prompt optical emission from GRB sources. 32 CCD cameras covering 2 steradians will monitor the sky continuously. The data will be analysed on-line in search for optical flashes. The prototype with 2 cameras operated at Las Campanas (Chile) since 2004 has recognised several outbursts of flaring stars and has given limits for a few GRB.

Electronics for a prototype variable field of view PET camera using the PMT-quadrant-sharing detector array

NASA Astrophysics Data System (ADS)

Li, H.; Wong, Wai-Hoi; Zhang, N.; Wang, J.; Uribe, J.; Baghaei, H.; Yokoyama, S.

1999-06-01

Electronics for a prototype high-resolution PET camera with eight position-sensitive detector modules has been developed. Each module has 16 BGO (Bi/sub 4/Ge/sub 3/O/sub 12/) blocks (each block is composed of 49 crystals). The design goals are component and space reduction. The electronics is composed of five parts: front-end analog processing, digital position decoding, fast timing, coincidence processing and master data acquisition. The front-end analog circuit is a zone-based structure (each zone has 3/spl times/3 PMTs). Nine ADCs digitize integration signals of an active zone identified by eight trigger clusters; each cluster is composed of six photomultiplier tubes (PMTs). A trigger corresponding to a gamma ray is sent to a fast timing board to obtain a time-mark, and the nine digitized signals are passed to the position decoding board, where a real block (four PMTs) can be picked out from the zone for position decoding. Lookup tables are used for energy discrimination and to identify the gamma-hit crystal location. The coincidence board opens a 70-ns initial timing window, followed by two 20-ns true/accidental time-mark lookup table windows. The data output from the coincidence board can be acquired either in sinogram mode or in list mode with a Motorola/IRONICS VME-based system.

Feasibility study on partial insulation winding technique for the development of self-protective MgB2 magnet

NASA Astrophysics Data System (ADS)

Kim, Y. G.; Kim, J. C.; Kim, J. M.; Yoo, B. H.; Hwang, D. Y.; Lee, H. G.

2018-06-01

This study investigates the feasibility of using the partial insulation winding technique for the development of a self-protective MgB2 MRI magnet with a fast charge-discharge rate. Charge-discharge and quench tests for a prototype PI MgB2 magnet confirmed that the magnet was successfully operated at full-field performance and exhibited self-protecting behavior in the event of a quench. Nonetheless, the required time to charge the 0.5-T/300-mm PI MgB2 magnet was almost five days, implying that the charge-discharge delay of the PI MgB2 magnet still needs to be ameliorated further to develop a real-scale MgB2 MRI magnet with a fast charge-discharge rate.

Overview of implementation of DARPA GPU program in SAIC

NASA Astrophysics Data System (ADS)

Braunreiter, Dennis; Furtek, Jeremy; Chen, Hai-Wen; Healy, Dennis

2008-04-01

This paper reviews the implementation of DARPA MTO STAP-BOY program for both Phase I and II conducted at Science Applications International Corporation (SAIC). The STAP-BOY program conducts fast covariance factorization and tuning techniques for space-time adaptive process (STAP) Algorithm Implementation on Graphics Processor unit (GPU) Architectures for Embedded Systems. The first part of our presentation on the DARPA STAP-BOY program will focus on GPU implementation and algorithm innovations for a prototype radar STAP algorithm. The STAP algorithm will be implemented on the GPU, using stream programming (from companies such as PeakStream, ATI Technologies' CTM, and NVIDIA) and traditional graphics APIs. This algorithm will include fast range adaptive STAP weight updates and beamforming applications, each of which has been modified to exploit the parallel nature of graphics architectures.

Development of real-time motion capture system for 3D on-line games linked with virtual character

NASA Astrophysics Data System (ADS)

Kim, Jong Hyeong; Ryu, Young Kee; Cho, Hyung Suck

2004-10-01

Motion tracking method is being issued as essential part of the entertainment, medical, sports, education and industry with the development of 3-D virtual reality. Virtual human character in the digital animation and game application has been controlled by interfacing devices; mouse, joysticks, midi-slider, and so on. Those devices could not enable virtual human character to move smoothly and naturally. Furthermore, high-end human motion capture systems in commercial market are expensive and complicated. In this paper, we proposed a practical and fast motion capturing system consisting of optic sensors, and linked the data with 3-D game character with real time. The prototype experiment setup is successfully applied to a boxing game which requires very fast movement of human character.

R and D program for core instrumentation improvements devoted for French sodium fast reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeannot, J. P.; Rodriguez, G.; Jammes, C.

2011-07-01

Under the framework of French R and D studies for Generation IV reactors and more specifically for sodium-cooled fast reactors (SFR); the CEA, EDF and AREVA have launched a joint coordinated research programme. This paper deals with the R and D sets out to achieve better inspection, maintenance, availability and decommissioning. In particular the instrumentation requirements for core monitoring and detection in the case of accidental events. Requirements mainly involve diversifying the means of protection and improving instrumentation performance in terms of responsiveness and sensitivity. Operation feedback from the Phenix and Superphenix prototype reactors and studies, carried out within themore » scope of the EFR projects, has been used to define the needs for instrumentation enhancement. (authors)« less

Variability of IN measured with the Fast Ice Nucleus Chamber (FINCH) at the high altitude research station Jungfraujoch during wintertime 2013

NASA Astrophysics Data System (ADS)

Frank, Fabian; Nillius, Björn; Bundke, Ulrich; Curtius, Joachim

2014-05-01

Ice nuclei (IN) are an important component of the atmospheric aerosol. Despite their low concentrations in the atmosphere, they have an influence on the formation of ice crystals in mixed-phase clouds and therefore on precipitation. The Fast Ice Nucleus CHamber (FINCH)1, a counter for ice nucleating particles developed at the Goethe University Frankfurt am Main allows long-term measurements of the IN number concentration. In FINCH the ice activation of the aerosol particles is achieved by mixing air flows with different temperature and humidity. The IN number concentration measurements at different meteorological conditions during the INUIT-JFJ campaign at the high altitude research station Jungfraujoch in Switzerland are presented and its variability are discussed. The good operational performance of the instrument allowed up to 10 hours of continuous measurements. Acknowledgment: This work was supported by the German Research Foundation, DFG Grant: BU 1432/3-2 BU 1432/4-1 in the framework of INUIT (FOR 1525) and SPP 1294 HALO. 1- Bundke, U., Nillius, B., Jaenicke, R., Wetter, T., Klein, H., and Bingemer, H. (2008). The fast ice nucleus chamber finch. Atmospheric Research, 90:180-186.

Miniaturized low-cost ion mobility spectrometer for fast detection of chemical warfare agents.

PubMed

Zimmermann, Stefan; Barth, Sebastian; Baether, Wolfgang K M; Ringer, Joachim

2008-09-01

Ion mobility spectrometry (IMS) is a well-known method for detecting hazardous compounds in air. Typical applications are the detection of chemical warfare agents, highly toxic industrial compounds, explosives, and drugs of abuse. Detection limits in the low part per billion range, fast response times, and simple instrumentation make this technique more and more popular. In particular, there is an increasing demand for miniaturized low-cost IMS for hand-held devices and air monitoring of public areas by sensor networks. In this paper, we present a miniaturized aspiration condenser type ion mobility spectrometer for fast detection of chemical warfare agents. The device is easy to manufacture and allows single substance identification down to low part per billion-level concentrations within seconds. The improved separation power results from ion focusing by means of geometric constraints and fluid dynamics. A simple pattern recognition algorithm is used for the identification of trained substances in air. The device was tested at the German Armed Forces Scientific Institute for Protection Technologies-NBC-Protection. Different chemical warfare agents, such as sarin, tabun, soman, US-VX, sulfur mustard, nitrogen mustard, and lewisite were tested. The results are presented here.

MIDAS, prototype Multivariate Interactive Digital Analysis System, phase 1. Volume 3: Wiring diagrams

NASA Technical Reports Server (NTRS)

Kriegler, F. J.; Christenson, D.; Gordon, M.; Kistler, R.; Lampert, S.; Marshall, R.; Mclaughlin, R.

1974-01-01

The Midas System is a third-generation, fast, multispectral recognition system able to keep pace with the large quantity and high rates of data acquisition from present and projected sensors. A principal objective of the MIDAS Program is to provide a system well interfaced with the human operator and thus to obtain large overall reductions in turn-around time and significant gains in throughput. The hardware and software generated in Phase I of the overall program are described. The system contains a mini-computer to control the various high-speed processing elements in the data path and a classifier which implements an all-digital prototype multivariate-Gaussian maximum likelihood decision algorithm operating at 2 x 100,000 pixels/sec. Sufficient hardware was developed to perform signature extraction from computer-compatible tapes, compute classifier coefficients, control the classifier operation, and diagnose operation. The MIDAS construction and wiring diagrams are given.

MIDAS, prototype Multivariate Interactive Digital Analysis System, Phase 1. Volume 2: Diagnostic system

NASA Technical Reports Server (NTRS)

Kriegler, F. J.; Christenson, D.; Gordon, M.; Kistler, R.; Lampert, S.; Marshall, R.; Mclaughlin, R.

1974-01-01

The MIDAS System is a third-generation, fast, multispectral recognition system able to keep pace with the large quantity and high rates of data acquisition from present and projected sensors. A principal objective of the MIDAS Program is to provide a system well interfaced with the human operator and thus to obtain large overall reductions in turn-around time and significant gains in throughout. The hardware and software generated in Phase I of the over-all program are described. The system contains a mini-computer to control the various high-speed processing elements in the data path and a classifier which implements an all-digital prototype multivariate-Gaussian maximum likelihood decision algorithm operating 2 x 105 pixels/sec. Sufficient hardware was developed to perform signature extraction from computer-compatible tapes, compute classifier coefficients, control the classifier operation, and diagnose operation. Diagnostic programs used to test MIDAS' operations are presented.

SALT, a dedicated readout chip for high precision tracking silicon strip detectors at the LHCb Upgrade

NASA Astrophysics Data System (ADS)

Bugiel, Sz.; Dasgupta, R.; Firlej, M.; Fiutowski, T.; Idzik, M.; Kuczynska, M.; Moron, J.; Swientek, K.; Szumlak, T.

2016-02-01

The Upstream Tracker (UT) silicon strip detector, one of the central parts of the tracker system of the modernised LHCb experiment, will use a new 128-channel readout ASIC called SALT. It will extract and digitise analogue signals from the UT sensors, perform digital signal processing and transmit a serial output data. The SALT is being designed in CMOS 130 nm process and uses a novel architecture comprising of analog front-end and fast (40 MSps) ultra-low power (<0.5 mW) 6-bit ADC in each channel. The prototype ASICs of important functional blocks, like analogue front-end, 6-bit SAR ADC, PLL, and DLL, were designed, fabricated and tested. A prototype of an 8-channel version of the SALT chip, comprising all important functionalities was also designed and fabricated. The architecture and design of the SALT, together with the selected preliminary tests results, are presented.

Upgrading the Digital Electronics of the PEP-II Bunch Current Monitors at the Stanford Linear Accelerator Center

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kline, Josh; /SLAC

2006-08-28

The testing of the upgrade prototype for the bunch current monitors (BCMs) in the PEP-II storage rings at the Stanford Linear Accelerator Center (SLAC) is the topic of this paper. Bunch current monitors are used to measure the charge in the electron/positron bunches traveling in particle storage rings. The BCMs in the PEP-II storage rings need to be upgraded because components of the current system have failed and are known to be failure prone with age, and several of the integrated chips are no longer produced making repairs difficult if not impossible. The main upgrade is replacing twelve old (1995)more » field programmable gate arrays (FPGAs) with a single Virtex II FPGA. The prototype was tested using computer synthesis tools, a commercial signal generator, and a fast pulse generator.« less

High resolution gamma-ray spectroscopy at high count rates with a prototype High Purity Germanium detector

NASA Astrophysics Data System (ADS)

Cooper, R. J.; Amman, M.; Vetter, K.

2018-04-01

High-resolution gamma-ray spectrometers are required for applications in nuclear safeguards, emergency response, and fundamental nuclear physics. To overcome one of the shortcomings of conventional High Purity Germanium (HPGe) detectors, we have developed a prototype device capable of achieving high event throughput and high energy resolution at very high count rates. This device, the design of which we have previously reported on, features a planar HPGe crystal with a reduced-capacitance strip electrode geometry. This design is intended to provide good energy resolution at the short shaping or digital filter times that are required for high rate operation and which are enabled by the fast charge collection afforded by the planar geometry crystal. In this work, we report on the initial performance of the system at count rates up to and including two million counts per second.

Beam test results of STS prototype modules for the future accelerator experiments FAIR/CBM and NICA/MPD projects

NASA Astrophysics Data System (ADS)

Kharlamov, Petr; Dementev, Dmitrii; Shitenkov, Mikhail

2017-10-01

High-energy heavy-ion collision experiments provide the unique possibility to create and investigate extreme states of strongly-interacted matter and address the fundamental aspects of QCD. The experimental investigation the QCD phase diagram would be a major breakthrough in our understanding of the properties of nuclear matter. The reconstruction of the charged particles created in the nuclear collisions, including the determination of their momenta, is the central detection task in high-energy heavy-ion experiments. It is taken up by the Silicon Tracking System in CBM@FAIR and by Inner Tracker in MPD@NICA currently under development. These experiments requires very fast and radiation hard detectors, a novel data read-out and analysis concept including free streaming front-end electronics. Thermal and beam tests of prototype detector modules for these tracking systems showed the stability of sensors and readout electronics operation.

Limiting factors in the production of deep microstructures

NASA Astrophysics Data System (ADS)

Tolfree, David W. L.; O'Neill, William; Tunna, Leslie; Sutcliffe, Christopher

1999-10-01

Microsystems increasingly require precision deep microstructures that can be cost-effectively designed and manufactured. New products must be able to meet the demands of the rapidly growing markets for microfluidic, micro- optical and micromechanical devices in industrial sectors which include chemicals, pharmaceuticals, biosciences, medicine and food. The realization of such products, first requires an effective process to design and manufacture prototypes. Two process methods used for the fabrication of high aspect-ratio microstructures are based on X-ray beam lithography with electroforming processes and direct micromachining with a frequency multiplied Nd:YAG laser using nanosecond pulse widths. Factors which limit the efficiency and precision obtainable using such processes are important parameters when deciding on the best fabrication method to use. A basic microstructure with narrow channels suitable for a microfluidic mixer have been fabricated using both these techniques and comparisons made of the limitations and suitability of the processes in respect of fast prototyping and manufacture or working devices.

Fast scanning probe for ophthalmic echography using an ultrasound motor.

PubMed

Carotenuto, Riccardo; Caliano, Giosuè; Caronti, Alessandro; Savoia, Alessandro; Pappalardo, Massimo

2005-11-01

High-frequency transducers, up to 35-50 MHz, are widely used in ophthalmic echography to image fine eye structures. Phased-array techniques are not practically applicable at such a high frequency, due to the too small size required for the single transducer element, and mechanical scanning is the only practical alternative. At present, all ophthalmic ultrasound systems use focused single-element, mechanically scanned probes. A good probe positioning and image evaluation feedback requires an image refresh-rate of about 15-30 frames per second, which is achieved in commercial mechanical scanning probes by using electromagnetic motors. In this work, we report the design, construction, and experimental characterization of the first mechanical scanning probe for ophthalmic echography based on a small piezoelectric ultrasound motor. The prototype probe reaches a scanning rate of 15 sectors per second, with very silent operation and little weight. The first high-frequency echographic images obtained with the prototype probe are presented.

Earth Science Data Fusion with Event Building Approach

NASA Technical Reports Server (NTRS)

Lukashin, C.; Bartle, Ar.; Callaway, E.; Gyurjyan, V.; Mancilla, S.; Oyarzun, R.; Vakhnin, A.

2015-01-01

Objectives of the NASA Information And Data System (NAIADS) project are to develop a prototype of a conceptually new middleware framework to modernize and significantly improve efficiency of the Earth Science data fusion, big data processing and analytics. The key components of the NAIADS include: Service Oriented Architecture (SOA) multi-lingual framework, multi-sensor coincident data Predictor, fast into-memory data Staging, multi-sensor data-Event Builder, complete data-Event streaming (a work flow with minimized IO), on-line data processing control and analytics services. The NAIADS project is leveraging CLARA framework, developed in Jefferson Lab, and integrated with the ZeroMQ messaging library. The science services are prototyped and incorporated into the system. Merging the SCIAMACHY Level-1 observations and MODIS/Terra Level-2 (Clouds and Aerosols) data products, and ECMWF re- analysis will be used for NAIADS demonstration and performance tests in compute Cloud and Cluster environments.

Prototype of a single probe Compton camera for laparoscopic surgery

NASA Astrophysics Data System (ADS)

Koyama, A.; Nakamura, Y.; Shimazoe, K.; Takahashi, H.; Sakuma, I.

2017-02-01

Image-guided surgery (IGS) is performed using a real-time surgery navigation system with three-dimensional (3D) position tracking of surgical tools. IGS is fast becoming an important technology for high-precision laparoscopic surgeries, in which the field of view is limited. In particular, recent developments in intraoperative imaging using radioactive biomarkers may enable advanced IGS for supporting malignant tumor removal surgery. In this light, we develop a novel intraoperative probe with a Compton camera and a position tracking system for performing real-time radiation-guided surgery. A prototype probe consisting of Ce :Gd3 Al2 Ga3 O12 (GAGG) crystals and silicon photomultipliers was fabricated, and its reconstruction algorithm was optimized to enable real-time position tracking. The results demonstrated the visualization capability of the radiation source with ARM = ∼ 22.1 ° and the effectiveness of the proposed system.

Design and Development of a Portable WiFi enabled BIA device

NASA Astrophysics Data System (ADS)

Križaj, D.; Baloh, M.; Brajkovič, R.; Žagar, T.

2013-04-01

A bioimpedance device (BIA) for evaluation of sarcopenia - age related muscle mass loss - is designed, developed and evaluated. The requirements were based on lightweight design, flexible and user enabled incorporation of measurement protocols and WiFi protocol for remote device control, full internet integration and fast development and usage of measurement protocols. The current design is based on usage of a microcontroller with integrated AD/DA converters. The prototype system was assembled and the operation and connectivity to different handheld devices and laptop computers was successfully tested. The designed BIA device can be accessed using TCP sockets and once the connection is established the data transfer runs successfully at the specified speed. The accuracy of currently developed prototype is about 5% for the impedance modulus and 5 deg. for the phase for the frequencies below 20 kHz with an unfiltered excitation signal and no additional amplifiers employed.

A space-efficient quantum computer simulator suitable for high-speed FPGA implementation

NASA Astrophysics Data System (ADS)

Frank, Michael P.; Oniciuc, Liviu; Meyer-Baese, Uwe H.; Chiorescu, Irinel

2009-05-01

Conventional vector-based simulators for quantum computers are quite limited in the size of the quantum circuits they can handle, due to the worst-case exponential growth of even sparse representations of the full quantum state vector as a function of the number of quantum operations applied. However, this exponential-space requirement can be avoided by using general space-time tradeoffs long known to complexity theorists, which can be appropriately optimized for this particular problem in a way that also illustrates some interesting reformulations of quantum mechanics. In this paper, we describe the design and empirical space/time complexity measurements of a working software prototype of a quantum computer simulator that avoids excessive space requirements. Due to its space-efficiency, this design is well-suited to embedding in single-chip environments, permitting especially fast execution that avoids access latencies to main memory. We plan to prototype our design on a standard FPGA development board.

Demonstration of the Cascadia G‐FAST geodetic earthquake early warning system for the Nisqually, Washington, earthquake

USGS Publications Warehouse

Crowell, Brendan; Schmidt, David; Bodin, Paul; Vidale, John; Gomberg, Joan S.; Hartog, Renate; Kress, Victor; Melbourne, Tim; Santillian, Marcelo; Minson, Sarah E.; Jamison, Dylan

2016-01-01

A prototype earthquake early warning (EEW) system is currently in development in the Pacific Northwest. We have taken a two‐stage approach to EEW: (1) detection and initial characterization using strong‐motion data with the Earthquake Alarm Systems (ElarmS) seismic early warning package and (2) the triggering of geodetic modeling modules using Global Navigation Satellite Systems data that help provide robust estimates of large‐magnitude earthquakes. In this article we demonstrate the performance of the latter, the Geodetic First Approximation of Size and Time (G‐FAST) geodetic early warning system, using simulated displacements for the 2001Mw 6.8 Nisqually earthquake. We test the timing and performance of the two G‐FAST source characterization modules, peak ground displacement scaling, and Centroid Moment Tensor‐driven finite‐fault‐slip modeling under ideal, latent, noisy, and incomplete data conditions. We show good agreement between source parameters computed by G‐FAST with previously published and postprocessed seismic and geodetic results for all test cases and modeling modules, and we discuss the challenges with integration into the U.S. Geological Survey’s ShakeAlert EEW system.

Peripheral nerve stimulation characteristics of an asymmetric head-only gradient coil compatible with a high-channel-count receiver array.

PubMed

Lee, Seung-Kyun; Mathieu, Jean-Baptiste; Graziani, Dominic; Piel, Joseph; Budesheim, Eric; Fiveland, Eric; Hardy, Christopher J; Tan, Ek Tsoon; Amm, Bruce; Foo, Thomas K-F; Bernstein, Matt A; Huston, John; Shu, Yunhong; Schenck, John F

2016-12-01

To characterize peripheral nerve stimulation (PNS) of an asymmetric head-only gradient coil that is compatible with a commercial high-channel-count receive-only array. Two prototypes of an asymmetric head-only gradient coil set with a 42-cm inner diameter were constructed for brain imaging at 3T with maximum performance specifications of up to 85 mT/m and 708 T/m/s. Tests were performed in 24 volunteers to measure PNS thresholds with the transverse (x = left-right; y = anterior-posterior [A/P]) gradient coils of both prototypes. Fourteen of these 24 volunteers were also tested for the z-gradient PNS in the second prototype and were scanned with high-slew-rate echo planar imaging (EPI) immediately after the PNS tests. For both prototypes, the y-gradient PNS threshold was markedly higher than the x-gradient threshold. The z-gradient threshold was intermediate between those for the x- and y-coils. Of the 24 volunteers, only two experienced y-gradient PNS at 80 mT/m and 500 T/m/s. All volunteers underwent the EPI scan without PNS when the readout direction was set to A/P. Measured PNS characteristics of asymmetric head-only gradient coil prototypes indicate that such coils, especially in the A/P direction, can be used for fast EPI readout in high-performance neuroimaging scans with substantially reduced PNS concerns compared with conventional whole body gradient coils. Magn Reson Med 76:1939-1950, 2016. © 2015 International Society for Magnetic Resonance in Medicine. © 2015 International Society for Magnetic Resonance in Medicine.

A Fault-Oblivious Extreme-Scale Execution Environment (FOX)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Hensbergen, Eric; Speight, William; Xenidis, Jimi

IBM Research’s contribution to the Fault Oblivious Extreme-scale Execution Environment (FOX) revolved around three core research deliverables: • collaboration with Boston University around the Kittyhawk cloud infrastructure which both enabled a development and deployment platform for the project team and provided a fault-injection testbed to evaluate prototypes • operating systems research focused on exploring role-based operating system technologies through collaboration with Sandia National Labs on the NIX research operating system and collaboration with the broader IBM Research community around a hybrid operating system model which became known as FusedOS • IBM Research also participated in an advisory capacity with themore » Boston University SESA project, the core of which was derived from the K42 operating system research project funded in part by DARPA’s HPCS program. Both of these contributions were built on a foundation of previous operating systems research funding by the Department of Energy’s FastOS Program. Through the course of the X-stack funding we were able to develop prototypes, deploy them on production clusters at scale, and make them available to other researchers. As newer hardware, in the form of BlueGene/Q, came online, we were able to port the prototypes to the new hardware and release the source code for the resulting prototypes as open source to the community. In addition to the open source coded for the Kittyhawk and NIX prototypes, we were able to bring the BlueGene/Q Linux patches up to a more recent kernel and contribute them for inclusion by the broader Linux community. The lasting impact of the IBM Research work on FOX can be seen in its effect on the shift of IBM’s approach to HPC operating systems from Linux and Compute Node Kernels to role-based approaches as prototyped by the NIX and FusedOS work. This impact can be seen beyond IBM in follow-on ideas being incorporated into the proposals for the Exasacale Operating Systems/Runtime program.« less

Urban History in 4 Dimensions - Supporting Research and Education

NASA Astrophysics Data System (ADS)

Münster, S.; Friedrichs, K.; Kröber, C.; Bruschke, J.; Henze, F.; Maiwald, F.; Niebling, F.

2017-08-01

The new research group on the four-dimensional research and communication of urban history (Urban History 4D) aims to investigate and develop methods and technologies to access extensive repositories of historical media and their contextual information in a spatial model, with an additional temporal component. This will make content accessible to different target groups, researchers and the public, via a 4D browser. A location-dependent augmented-reality representation can be used as an information base, research tool, and means of communicating historical knowledge. The data resources for this research include extensive holdings of historical photographs of Dresden, which have documented the city over the decades, and digitized map collections from the Deutsche Fotothek (German photographic collection) platform. These will lay the foundation for a prototype model which will give users a virtual experience of historic parts of Dresden.

The NUTS CubeSat Project: Spin-Offs and Technology Development

NASA Astrophysics Data System (ADS)

Birkeland, R.; Stein, T. A.; Tommer, M.; Beermann, B.; Petrasch, J.; Gjersvik, A.

2015-09-01

The development of CubeSats allows for the conception and implementation of new approaches and technologies. In this paper we present a spin-off and technology innovation resulting from the NTNU Test Satellite (NUTS). NUTS is a 2U CubeSat under development by students of the Norwegian University of Science and Technology (NTNU) in Trondheim, Norway. The satellite is due to launch in 2017 and is based upon in-house developments. We will describe the innovative carbon-fibre frame, radio systems and proposals for an infrared camera for atmospheric gravity waves observations. A NUTS spinoff, the Cosmic Particle Telescope (CPT-SCOPE), will be presented in greater detail since it has been selected for the BEXUS 20 campaign in autumn 2015. CPT-SCOPE is a Norwegian-German compact radiation monitor prototype developed by students.

The AMchip04 and the processing unit prototype for the FastTracker

NASA Astrophysics Data System (ADS)

Andreani, A.; Annovi, A.; Beretta, M.; Bogdan, M.; Citterio, M.; Alberti, F.; Giannetti, P.; Lanza, A.; Magalotti, D.; Piendibene, M.; Shochet, M.; Stabile, A.; Tang, J.; Tompkins, L.; Volpi, G.

2012-08-01

Modern experiments search for extremely rare processes hidden in much larger background levels. As the experiment`s complexity, the accelerator backgrounds and luminosity increase we need increasingly complex and exclusive event selection. We present the first prototype of a new Processing Unit (PU), the core of the FastTracker processor (FTK). FTK is a real time tracking device for the ATLAS experiment`s trigger upgrade. The computing power of the PU is such that a few hundred of them will be able to reconstruct all the tracks with transverse momentum above 1 GeV/c in ATLAS events up to Phase II instantaneous luminosities (3 × 1034 cm-2 s-1) with an event input rate of 100 kHz and a latency below a hundred microseconds. The PU provides massive computing power to minimize the online execution time of complex tracking algorithms. The time consuming pattern recognition problem, generally referred to as the ``combinatorial challenge'', is solved by the Associative Memory (AM) technology exploiting parallelism to the maximum extent; it compares the event to all pre-calculated ``expectations'' or ``patterns'' (pattern matching) simultaneously, looking for candidate tracks called ``roads''. This approach reduces to a linear behavior the typical exponential complexity of the CPU based algorithms. Pattern recognition is completed by the time data are loaded into the AM devices. We report on the design of the first Processing Unit prototypes. The design had to address the most challenging aspects of this technology: a huge number of detector clusters (``hits'') must be distributed at high rate with very large fan-out to all patterns (10 Million patterns will be located on 128 chips placed on a single board) and a huge number of roads must be collected and sent back to the FTK post-pattern-recognition functions. A network of high speed serial links is used to solve the data distribution problem.

A MATLAB Library for Rapid Prototyping of Wireless Communications Algorithms with the Universal Software Radio Peripheral (USRP) Radio Family

DTIC Science & Technology

2013-06-01

Radio is a software development toolkit that provides signal processing blocks to drive the SDR. GNU Radio has many strong points – it is actively...maintained with a large user base, new capabilities are constantly being added, and compiled C code is fast for many real-time applications such as...programming interface (API) makes learning the architecture a daunting task, even for the experienced software developer. This requirement poses many

Efficient hybrid-symbolic methods for quantum mechanical calculations

NASA Astrophysics Data System (ADS)

Scott, T. C.; Zhang, Wenxing

2015-06-01

We present hybrid symbolic-numerical tools to generate optimized numerical code for rapid prototyping and fast numerical computation starting from a computer algebra system (CAS) and tailored to any given quantum mechanical problem. Although a major focus concerns the quantum chemistry methods of H. Nakatsuji which has yielded successful and very accurate eigensolutions for small atoms and molecules, the tools are general and may be applied to any basis set calculation with a variational principle applied to its linear and non-linear parameters.

A novel microcontroller-based digital instrument for measurement of electrical quantities under non-sinusoidal condition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anaya, O.; Moreno, G.E.L.; Madrigal, M.M.

1999-11-01

In the last years, several definitions of power have been proposed for more accurate measurement of electrical quantities in presence of harmonics pollution on power lines. Nevertheless, only few instruments have been constructed considering these definitions. This paper describes a new microcontroller-based digital instrument, which include definitions based on Harley Transform. The algorithms are fully processed using Fast Hartley Transform (FHT) and 16 bit-microcontroller platform. The constructed prototype was compared with commercial harmonics analyzer instrument.

Fabrication of fuel pin assemblies, phase 3

NASA Technical Reports Server (NTRS)

Keeton, A. R.; Stemann, L. G.

1972-01-01

Five full size and eight reduced length fuel pins were fabricated for irradiation testing to evaluate design concepts for a fast spectrum lithium cooled compact space power reactor. These assemblies consisted of uranium mononitride fuel pellets encased in a T-111 (Ta-8W-2Hf) clad with a tungsten barrier separating fuel and clad. Fabrication procedures were fully qualified by process development and assembly qualification tests. Detailed specifications and procedures were written for the fabrication and assembly of prototype fuel pins.

BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".

PubMed

Chen, Deliang; Savidge, Tor

2015-08-28

Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric field-dependent acceleration of biological catalysis using ketosteroid isomerase as a prototypic example. These findings were not extended to aqueous solution because water by itself has field fluctuations that are too large and fast to provide a catalytic effect. Given physiological context, when water electrostatic interactions are considered, electric fields play a less important role in the catalysis. Copyright © 2015, American Association for the Advancement of Science.

MaNIDA: an operational infrastructure for shipborne data

NASA Astrophysics Data System (ADS)

Macario, Ana; Scientific MaNIDA Team

2013-04-01

The Marine Network for Integrated Data Access (MaNIDA) aims to build a sustainable e-Infrastruture to support discovery and re-use of data archived in a distributed network of data providers in Germany (see related abstracts in session ESSI1.2 and session ESSI2.2). Because one of the primary focus of MaNIDA is the underway data acquired on board of German academic research vessels, we will be addressing various issues related to cruise-level metadata, shiptrack navigation, sampling events conducted during the cruise (event logs), standardization of device-related (type, name, parameters) and place-related (gazetteer) vocabularies, QA/QC procedures (near real time and post-cruise validation, corrections, quality flags) as well as ingestion and management of contextual information (e.g. various types of cruise-related reports and project-related information). One of MaNIDA's long-term goal is to be able to offer an integrative "one-stop-shop" framework for management and access of ship-related information based on international standards and interoperability. This access framework will be freely available and is intended for scientists, funding agencies and the public. The master "catalog" we are building currently contains information from 13 German academic research vessels and respective cruises (to date ~1900 cruises with expected growing rate of ~150 cruises annually). Moreover, MaNIDA's operational infrastructure will additionally provide a direct pipeline to SeaDataNet Cruise Summary Report Inventory, among others. In this presentation, we will focus on the extensions we are currently implementing to support automated acquisition and standardized transfer of various types of data from German research vessels to hosts on land. Our concept towards nationwide common QA/QC procedures for various types of underway data (including versioning concept) and common workflows will also be presented. The "linking" of cruise-related information with quality-controlled data and data products (e.g., digital terrain models), publications, cruise-related reports, people and other contextual information will be additionally shown in the framework of a prototype for R.V. Polarstern.

Improving data management and dissemination in web based information systems by semantic enrichment of descriptive data aspects

NASA Astrophysics Data System (ADS)

Gebhardt, Steffen; Wehrmann, Thilo; Klinger, Verena; Schettler, Ingo; Huth, Juliane; Künzer, Claudia; Dech, Stefan

2010-10-01

The German-Vietnamese water-related information system for the Mekong Delta (WISDOM) project supports business processes in Integrated Water Resources Management in Vietnam. Multiple disciplines bring together earth and ground based observation themes, such as environmental monitoring, water management, demographics, economy, information technology, and infrastructural systems. This paper introduces the components of the web-based WISDOM system including data, logic and presentation tier. It focuses on the data models upon which the database management system is built, including techniques for tagging or linking metadata with the stored information. The model also uses ordered groupings of spatial, thematic and temporal reference objects to semantically tag datasets to enable fast data retrieval, such as finding all data in a specific administrative unit belonging to a specific theme. A spatial database extension is employed by the PostgreSQL database. This object-oriented database was chosen over a relational database to tag spatial objects to tabular data, improving the retrieval of census and observational data at regional, provincial, and local areas. While the spatial database hinders processing raster data, a "work-around" was built into WISDOM to permit efficient management of both raster and vector data. The data model also incorporates styling aspects of the spatial datasets through styled layer descriptions (SLD) and web mapping service (WMS) layer specifications, allowing retrieval of rendered maps. Metadata elements of the spatial data are based on the ISO19115 standard. XML structured information of the SLD and metadata are stored in an XML database. The data models and the data management system are robust for managing the large quantity of spatial objects, sensor observations, census and document data. The operational WISDOM information system prototype contains modules for data management, automatic data integration, and web services for data retrieval, analysis, and distribution. The graphical user interfaces facilitate metadata cataloguing, data warehousing, web sensor data analysis and thematic mapping.

Electronic Implementation of Integrated End-of-life Care: A Local Approach

PubMed Central

Schlieper, Daniel; Altreuther, Christiane; Schallenburger, Manuela; Neukirchen, Martin; Schmitz, Andrea

2017-01-01

Introduction: The Liverpool Care Pathway for the Dying Patient is an instrument to deliver integrated care for patients in their last hours of life. Originally a paper-based system, this study investigates the feasibility of an electronic version. Methods: An electronic Liverpool Care Pathway was implemented in a specialized palliative care unit of a German university hospital. Its use is exemplified by means of auditing and analysis of the proportion of recorded items. Results: In the years 2013 and 2014 the electronic Liverpool Care Pathway was used for the care of 159 patients. The uptake of the instrument was high (67%). Most items were recorded. Apart from a high usability, the fast data retrieval allows fast analysis for auditing and research. Conclusions and discussion: The electronic instrument is feasible in a computerized ward and has strong advantages for retrospective analysis. Trial registration: Internal Clinical Trial Register of the Medical Faculty, Heinrich Heine University Düsseldorf, No. 2015124683 (7 December 2015). PMID:28970746

Next generation fuel irradiation capability in the High Flux Reactor Petten

NASA Astrophysics Data System (ADS)

Fütterer, Michael A.; D'Agata, Elio; Laurie, Mathias; Marmier, Alain; Scaffidi-Argentina, Francesco; Raison, Philippe; Bakker, Klaas; de Groot, Sander; Klaassen, Frodo

2009-07-01

This paper describes selected equipment and expertise on fuel irradiation testing at the High Flux Reactor (HFR) in Petten, The Netherlands. The reactor went critical in 1961 and holds an operating license up to at least 2015. While HFR has initially focused on Light Water Reactor fuel and materials, it also played a decisive role since the 1970s in the German High Temperature Reactor (HTR) development program. A variety of tests related to fast reactor development in Europe were carried out for next generation fuel and materials, in particular for Very High Temperature Reactor (V/HTR) fuel, fuel for closed fuel cycles (U-Pu and Th-U fuel cycle) and transmutation, as well as for other innovative fuel types. The HFR constitutes a significant European infrastructure tool for the development of next generation reactors. Experimental facilities addressed include V/HTR fuel tests, a coated particle irradiation rig, and tests on fast reactor, transmutation and thorium fuel. The rationales for these tests are given, results are provided and further work is outlined.

Applications of a Fast Neutron Detector System to Verification of Special Nuclear Materials

NASA Astrophysics Data System (ADS)

Mayo, Douglas R.; Byrd, Roger C.; Ensslin, Norbert; Krick, Merlyn S.; Mercer, David J.; Miller, Michael C.; Prettyman, Thomas H.; Russo, Phyllis A.

1998-04-01

An array of boron-loaded plastic optically coupled to bismuth germanate scintillators has been developed to detect neutrons for measurement of special nuclear materials. The phoswiched detection system has the advantage of a high neutron detection efficiency and short die-away time. This is achieved by mixing the moderator (plastic) and the detector (^10B) at the molecular level. Simulations indicate that the neutron capture probabilities equal or exceed those of the current thermal neutron multiplicity techniques which have the moderator (polyethylene) and detectors (^3He gas proportional tubes) macroscopically separate. Experiments have been performed to characterize the response of these detectors and validate computer simulations. The fast neutron detection system may be applied to the quantitative assay of plutonium in high (α,n) backgrounds, with emphasis on safeguards and enviromental scenarios. Additional applications of the insturment, in a non-quantative mode, has been tested for possible verification activities involving dismantlement of nuclear weapons. A description of the detector system, simulations and preliminary data will be presented.

Pinning of topological solitons at extrinsic defects in a quasi one-dimensional charge density wave

NASA Astrophysics Data System (ADS)

Razzaq, Samad; Wippermann, Stefan; Tae Hwan Kim Collaboration; Han Woong Yeom Collaboration

Quasi one-dimensional (1D) electronic systems are known to exhibit exotic physical phenomena, such as, e.g., Jahn Teller distortions, charge density wave (CDW) formation and non-Fermi liquid behavior. Solitonic excitations of the charge density wave ordered ground state and associated topological edge states in atomic wires are presently the focus of increasing attention. We carried out a combined ab initio and scanning tunneling microscopy (STM) study of solitonic and non-solitonic phase defects in the In/Si(111) atomic wire array. While free solitons move too fast to be imaged directly in STM, they can become trapped at extrinsic de- fects within the wire. We discuss the detailed atomistic structure of the responsible extrinsic defects and trapped solitons. Our study highlights the key role of coupled theory-experimental investigations in order to understand also the elusive fast moving solitons. S. W. gratefully acknowledges financial support from the German Research Foundation (DFG), Grant No. FOR1700.

[Laparoscopic "fast-track" sigmoidectomy for diverticulitis disease in Germany. Results of a prospective quality assurance program].

PubMed

Tsilimparis, N; Haase, O; Wendling, P; Kipfmüller, K; Schmid, M; Engemann, R; Schwenk, W

2010-09-01

The natural course of sigmoid colon diverticulitis during conservative therapy and the assessment of the perioperative morbidity after sigmoid colon resection are differently evaluated by surgeons and gastroenterologists. The "fast-track" rehabilitation accelerates the reconvalescence and reduces the rate of postoperative general complications after colorectal surgery. The results of the laparoscopic "Fast-track" sigmoidectomy should be examined within a quality assurance program to better evaluate the perioperative risks following surgical management of diverticulitis. A prospective data collection within the voluntary quality assurance program "fast-track" Kolon II was performed. All participating clinics agreed on a multimodal, evidence-based standard perioperative treatment in terms of a "fast-track" rehabilitation for elective operations for sigmoid diverticulitis. Data from 846 patients undergoing laparoscopic "fast-track" sigmoid colon resection in 23 surgical departments in Germany were collected and evaluated. The mean age of the patients was 63 years (range 23 - 91). 203 patients (24 %) had severe co-morbidities (ASA classification III - IV). A conversion to conventional open surgery was necessary in 51 cases (6 %). Complications occurred in 93 patients (11 %). 76 patients suffered a surgical complication (8.9 %) and 32 patients (3.8 %) a general complication. Two patients died postoperatively due to multi-organ failure following anastomotic leaks. The patients took solid food in median on day 1 after surgery (range, 0 - 5) and passed stool on day 2 (range, 0 - 22). Predefined discharge criteria (free of pain on oral medication, normal oral feeding, stool) were met on day 4 (range, 1 - 58) and the patients were discharged on day 7 (range, 3 - 72). The 30-day re-admission rate was 3.9 %. Patients undergoing laparoscopic "fast-track" sigmoidectomy had a low rate of general complications and had a rapid reconvalescence with a short postoperative in-patient treatment as documented in a german quality assurance program. Copyright Georg Thieme Verlag KG Stuttgart . New York.

Single-photon sensitive fast ebCMOS camera system for multiple-target tracking of single fluorophores: application to nano-biophotonics

NASA Astrophysics Data System (ADS)

Cajgfinger, Thomas; Chabanat, Eric; Dominjon, Agnes; Doan, Quang T.; Guerin, Cyrille; Houles, Julien; Barbier, Remi

2011-03-01

Nano-biophotonics applications will benefit from new fluorescent microscopy methods based essentially on super-resolution techniques (beyond the diffraction limit) on large biological structures (membranes) with fast frame rate (1000 Hz). This trend tends to push the photon detectors to the single-photon counting regime and the camera acquisition system to real time dynamic multiple-target tracing. The LUSIPHER prototype presented in this paper aims to give a different approach than those of Electron Multiplied CCD (EMCCD) technology and try to answer to the stringent demands of the new nano-biophotonics imaging techniques. The electron bombarded CMOS (ebCMOS) device has the potential to respond to this challenge, thanks to the linear gain of the accelerating high voltage of the photo-cathode, to the possible ultra fast frame rate of CMOS sensors and to the single-photon sensitivity. We produced a camera system based on a 640 kPixels ebCMOS with its acquisition system. The proof of concept for single-photon based tracking for multiple single-emitters is the main result of this paper.

Combining endoscopic ultrasound with Time-Of-Flight PET: The EndoTOFPET-US Project

NASA Astrophysics Data System (ADS)

Frisch, Benjamin

2013-12-01

The EndoTOFPET-US collaboration develops a multimodal imaging technique for endoscopic exams of the pancreas or the prostate. It combines the benefits of high resolution metabolic imaging with Time-Of-Flight Positron Emission Tomography (TOF PET) and anatomical imaging with ultrasound (US). EndoTOFPET-US consists of a PET head extension for a commercial US endoscope and a PET plate outside the body in coincidence with the head. The high level of miniaturization and integration creates challenges in fields such as scintillating crystals, ultra-fast photo-detection, highly integrated electronics, system integration and image reconstruction. Amongst the developments, fast scintillators as well as fast and compact digital SiPMs with single SPAD readout are used to obtain the best coincidence time resolution (CTR). Highly integrated ASICs and DAQ electronics contribute to the timing performances of EndoTOFPET. In view of the targeted resolution of around 1 mm in the reconstructed image, we present a prototype detector system with a CTR better than 240 ps FWHM. We discuss the challenges in simulating such a system and introduce reconstruction algorithms based on graphics processing units (GPU).

A full Monte Carlo simulation of the YAP-PEM prototype for breast tumor detection

NASA Astrophysics Data System (ADS)

Motta, A.; Righi, S.; Del Guerra, A.; Belcari, N.; Vaiano, A.; De Domenico, G.; Zavattini, G.; Campanini, R.; Lanconelli, N.; Riccardi, A.

2004-07-01

A prototype for Positron Emission Mammography, the YAP-PEM, is under development within a collaboration of the Italian Universities of Pisa, Ferrara, and Bologna. The aim is to detect breast lesions, with dimensions of 5 mm in diameter, and with a specific activity ratio of 10:1 between the cancer and breast tissue. The YAP-PEM is composed of two stationary detection heads of 6×6 cm 2, composed of a matrix of 30×30 YAP:Ce finger crystals of 2×2×30 mm 3 each. The EGSnrc Monte Carlo code has been used to simulate several characteristics of the prototype. A fast EM algorithm has been adapted to reconstruct all of the collected lines of flight, also at large incidence angles, by achieving 3D positioning capability of the lesion in the FOV. The role of the breast compression has been studied. The performed study shows that a 5 mm diameter tumor of 37 kBq/cm 3 (1 μCi/cm 3), embedded in active breast tissue with 10:1 tumor/background specific activity ratio, is detected in 10 min with a Signal-to-Noise Ratio of 8.7±1.0. Two hot lesions in the active breast phantom are clearly visible in the reconstructed image.

Process-Structure-Property Relationships for 316L Stainless Steel Fabricated by Additive Manufacturing and Its Implication for Component Engineering

NASA Astrophysics Data System (ADS)

Yang, Nancy; Yee, J.; Zheng, B.; Gaiser, K.; Reynolds, T.; Clemon, L.; Lu, W. Y.; Schoenung, J. M.; Lavernia, E. J.

2017-04-01

We investigate the process-structure-property relationships for 316L stainless steel prototyping utilizing 3-D laser engineered net shaping (LENS), a commercial direct energy deposition additive manufacturing process. The study concluded that the resultant physical metallurgy of 3-D LENS 316L prototypes is dictated by the interactive metallurgical reactions, during instantaneous powder feeding/melting, molten metal flow and liquid metal solidification. The study also showed 3-D LENS manufacturing is capable of building high strength and ductile 316L prototypes due to its fine cellular spacing from fast solidification cooling, and the well-fused epitaxial interfaces at metal flow trails and interpass boundaries. However, without further LENS process control and optimization, the deposits are vulnerable to localized hardness variation attributed to heterogeneous microstructure, i.e., the interpass heat-affected zone (HAZ) from repetitive thermal heating during successive layer depositions. Most significantly, the current deposits exhibit anisotropic tensile behavior, i.e., lower strain and/or premature interpass delamination parallel to build direction (axial). This anisotropic behavior is attributed to the presence of interpass HAZ, which coexists with flying feedstock inclusions and porosity from incomplete molten metal fusion. The current observations and findings contribute to the scientific basis for future process control and optimization necessary for material property control and defect mitigation.

Rapid prototyping of an EEG-based brain-computer interface (BCI).

PubMed

Guger, C; Schlögl, A; Neuper, C; Walterspacher, D; Strein, T; Pfurtscheller, G

2001-03-01

The electroencephalogram (EEG) is modified by motor imagery and can be used by patients with severe motor impairments (e.g., late stage of amyotrophic lateral sclerosis) to communicate with their environment. Such a direct connection between the brain and the computer is known as an EEG-based brain-computer interface (BCI). This paper describes a new type of BCI system that uses rapid prototyping to enable a fast transition of various types of parameter estimation and classification algorithms to real-time implementation and testing. Rapid prototyping is possible by using Matlab, Simulink, and the Real-Time Workshop. It is shown how to automate real-time experiments and perform the interplay between on-line experiments and offline analysis. The system is able to process multiple EEG channels on-line and operates under Windows 95 in real-time on a standard PC without an additional digital signal processor (DSP) board. The BCI can be controlled over the Internet, LAN or modem. This BCI was tested on 3 subjects whose task it was to imagine either left or right hand movement. A classification accuracy between 70% and 95% could be achieved with two EEG channels after some sessions with feedback using an adaptive autoregressive (AAR) model and linear discriminant analysis (LDA).

Novel Photon-Counting Detectors for Free-Space Communication

NASA Technical Reports Server (NTRS)

Krainak, Michael A.; Yang, Guan; Sun, Xiaoli; Lu, Wei; Merritt, Scott; Beck, Jeff

2016-01-01

We present performance data for novel photon counting detectors for free space optical communication. NASA GSFC is testing the performance of three novel photon counting detectors 1) a 2x8 mercury cadmium telluride avalanche array made by DRS Inc. 2) a commercial 2880 silicon avalanche photodiode array and 3) a prototype resonant cavity silicon avalanche photodiode array. We will present and compare dark count, photon detection efficiency, wavelength response and communication performance data for these detectors. We discuss system wavelength trades and architectures for optimizing overall communication link sensitivity, data rate and cost performance. The HgCdTe APD array has photon detection efficiencies of greater than 50 were routinely demonstrated across 5 arrays, with one array reaching a maximum PDE of 70. High resolution pixel-surface spot scans were performed and the junction diameters of the diodes were measured. The junction diameter was decreased from 31 m to 25 m resulting in a 2x increase in e-APD gain from 470 on the 2010 array to 1100 on the array delivered to NASA GSFC. Mean single photon SNRs of over 12 were demonstrated at excess noise factors of 1.2-1.3.The commercial silicon APD array has a fast output with rise times of 300ps and pulse widths of 600ps. Received and filtered signals from the entire array are multiplexed onto this single fast output. The prototype resonant cavity silicon APD array is being developed for use at 1 micron wavelength.

Mass tracking and material accounting in the Integral Fast Reactor (IFR)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Orechwa, Y.; Adams, C.H.; White, A.M.

1991-01-01

The Integral Fast Reactor (IFR) is a generic advanced liquid metal cooled reactor concept being developed at Argonne National Laboratory (ANL). There are a number of technical features of the IFR which contribute to its potential as a next-generation reactor. These are associated with large safety margins with regard to off-normal events involving the heat transport system, and the use of metallic fuel which makes possible the utilization of innovative fuel cycle processes. The latter feature permits fuel cycle closure the compact, low-cost reprocessing facilities, collocated with the reactor plant. These primary features are being demonstrated in the facilities atmore » ANL-West, utilizing Experimental Breeder Reactor 2 and the associated Fuel Cycle Facility (FCF) as an IFR prototype. The demonstration of this IFR prototype includes the design and implementation of the Mass-Tracking System (MTG). In this system, data from the operations of the FCF, including weights and batch-process parameters, are collected and maintained by the MTG running on distributed workstations. The components of the MTG System include: (1) an Oracle database manager with a Fortran interface, (2) a set of MTG Tasks'' which collect, manipulate and report data, (3) a set of MTG Terminal Sessions'' which provide some interactive control of the Tasks, and (4) a set of servers which manage the Tasks and which provide the communications link between the MTG System and Operator Control Stations, which control process equipment and monitoring devices within the FCF.« less

A 10Gbps optical burst switching network incorporating ultra-fast (5ns) wavelength switched tunable laser sources

NASA Astrophysics Data System (ADS)

Ryan, Neil; Todd, Michael; Farrell, Tom; Lavin, Adrian; Rigole, Pierre-Jean; Corbett, Brian; Roycroft, Brendan; Engelstaedter, Jan-Peter

2017-11-01

This paper outlines the development of a prototype optical burst mode switching network based upon a star topology, the ultimate application of which could be as a transparent payload processor onboard satellite repeaters. The network architecture incorporates multiple tunable laser sources, burst mode receivers and a passive optical router (Arrayed Waveguide Grating). Each tunable optical signal should carry >=10Gbps and be capable of wavelength switching in c. 5ns timescales. Two monolithic tunable laser types, based upon different technologies, will be utilised: a Slotted Fabry Perot laser (a Fabry Perot laser with slots added in order to introduce controlled cavity perturbations); and a Modulated Grating Y-Branch Laser (MGY: a widely tunable, multi-section device similar to the DBR laser). While the Slotted Fabry Perot laser is expected to achieve the required switching times, it is an immature technology not yet capable of achieving tunability over 80 ITU channels from a single chip. The MGY device is a more mature technology and has full C-band ITU channel coverage, but is not capable of the required short switching times. Hence, in order to facilitate the integration of this more mature technology into the prototype breadboard with the requisite switching time capabilities, a system of `dual laser' transmitters is being developed to enable data transmission from one MGY laser while the other switches and vice-versa. This work is being performed under ESA contract AO 1-5025/06/NL/PM, Optical Technologies for Ultra - fast Processing.

Policing epistemic deviance: Albert Von Schrenck-Notzing and Albert Moll(1).

PubMed

Sommer, Andreas

2012-04-01

Shortly after the death of Albert von Schrenck-Notzing (1862-1929), the doyen of early twentieth century German para psychology, his former colleague in hypnotism and sexology Albert Moll (1862-1939) published a treatise on the psychology and pathology of parapsychologists, with Schrenck-Notzing serving as a prototype of a scientist suffering from an 'occult complex'. Moll's analysis concluded that parapsychologists vouching for the reality of supernormal phenomena, such as telepathy, clairvoyance, telekinesis and materialisations, suffered from a morbid will to believe, which paralysed their critical faculties and made them cover obvious mediumistic fraud. Using Moll's treatment of Schrenck-Notzing as an historical case study of boundary disputes in science and medicine, this essay traces the career of Schrenck-Notzing as a researcher in hypnotism, sexology and parapsychology; discusses the relationship between Moll and Schrenck-Notzing; and problematises the pathologisation and defamation strategies of deviant epistemologies by authors such as Moll.

Einstein and Planck

NASA Astrophysics Data System (ADS)

Heilbron, John

2005-03-01

As an editor of the Annalen der Physik, Max Planck published Einstein's early papers on thermodynamics and on special relativity, which Planck probably was the first major physicist to appreciate. They respected one another not only as physicists but also, for their inspired creation of world pictures, as artists. Planck helped to establish Einstein in a sinecure at the center of German physics, Berlin. Despite their differences in scientific style, social life, politics, and religion, they became fast friends. Their mutual admiration survived World War I, during which Einstein advocated pacifism and Planck signed the infamous Manifesto of the 93 Intellectuals supporting the German invasion of Belgium. It also survived the Weimar Republic, which Einstein favored and Planck disliked. Physics drew them together, as both opposed the Copenhagen Interpretation; so did common decency, as Planck helped to protect Einstein from anti-semitic attacks. Their friendship did not survive the Nazis. As a standing secretary of the Berlin Academy, Planck had to advise Einstein to resign from it before his colleagues, outraged at his criticism of the new Germany from the safety of California, expelled him. Einstein never forgave his old friend and former fellow artist for not protesting publicly against his expulsion and denigration, and other enormities of National Socialism. .

Fast widely-tunable single-frequency 2-micron laser for remote-sensing applications

NASA Astrophysics Data System (ADS)

Henderson, Sammy W.; Hale, Charley P.

2017-08-01

We are developing a family of fast, widely-tunable cw diode-pumped single frequency solid-state lasers, called Swift. The Swift laser architecture is compatible with operation using many different solid-state laser crystals for operation at various emission lines between 1 and 2.1 micron. The initial prototype Swift laser using a Tm,Ho:YLF laser crystal near 2.05 micron wavelength achieved over 100 mW of single frequency cw output power, up to 50 GHz-wide, fast, mode-hop-free piezoelectric tunability, and 100 kHz/ms frequency stability. For the Tm,Ho:YLF laser material, the fast 50 GHz tuning range can be centered at any wavelength from 2047-2059 nm using appropriate intracavity spectral filters. The frequency stability and power are sufficient to serve as the local oscillator (LO) laser in long-range coherent wind-measuring lidar systems, as well as a frequency-agile master oscillator (MO) or injection-seed source for larger pulsed transmitter lasers. The rapid and wide frequency tunablity meets the requirements for integrated-path or range-resolved differential absorption lidar or applications where targets with significantly different line of sight velocities (Doppler shifts) must be tracked. Initial demonstration of an even more compact version of the Swift is also described which requires less prime power and produces less waste heat.

Fast-neutron and gamma-ray imaging with a capillary liquid xenon converter coupled to a gaseous photomultiplier

NASA Astrophysics Data System (ADS)

Israelashvili, I.; Coimbra, A. E. C.; Vartsky, D.; Arazi, L.; Shchemelinin, S.; Caspi, E. N.; Breskin, A.

2017-09-01

Gamma-ray and fast-neutron imaging was performed with a novel liquid xenon (LXe) scintillation detector read out by a Gaseous Photomultiplier (GPM). The 100 mm diameter detector prototype comprised a capillary-filled LXe converter/scintillator, coupled to a triple-THGEM imaging-GPM, with its first electrode coated by a CsI UV-photocathode, operated in Ne/5%CH4 at cryogenic temperatures. Radiation localization in 2D was derived from scintillation-induced photoelectron avalanches, measured on the GPM's segmented anode. The localization properties of 60Co gamma-rays and a mixed fast-neutron/gamma-ray field from an AmBe neutron source were derived from irradiation of a Pb edge absorber. Spatial resolutions of 12± 2 mm and 10± 2 mm (FWHM) were reached with 60Co and AmBe sources, respectively. The experimental results are in good agreement with GEANT4 simulations. The calculated ultimate expected resolutions for our application-relevant 4.4 and 15.1 MeV gamma-rays and 1-15 MeV neutrons are 2-4 mm and ~ 2 mm (FWHM), respectively. These results indicate the potential applicability of the new detector concept to Fast-Neutron Resonance Radiography (FNRR) and Dual-Discrete-Energy Gamma Radiography (DDEGR) of large objects.

The Soft X-ray View of Ultra Fast Outflows

NASA Astrophysics Data System (ADS)

Reeves, J.; Braito, V.; Nardini, E.; Matzeu, G.; Lobban, A.; Costa, M.; Pounds, K.; Tombesi, F.; Behar, E.

2017-10-01

The recent large XMM-Newton programmes on the nearby quasars PDS 456 and PG 1211+143 have revealed prototype ultra fast outflows in the iron K band through highly blue shifted absorption lines. The wind velocities are in excess of 0.1c and are likely to make a significant contribution to the host galaxy feedback. Here we present evidence for the signature of the fast wind in the soft X-ray band from these luminous quasars, focusing on the spectroscopy with the RGS. In PDS 456, the RGS spectra reveal the presence of soft X-ray broad absorption line profiles, which suggests that PDS 456 is an X-ray equivalent to the BAL quasars, with outflow velocities reaching 0.2c. In PG 1211, the soft X-ray RGS spectra show a complex of several highly blue shifted absorption lines over a wide range of ionisation and reveal outflowing components with velocities between 0.06-0.17c. For both quasars, the soft X-ray absorption is highly variable, even on timescales of days and is most prominent when the quasar flux is low. Overall the results imply the presence of a soft X-ray component of the ultra fast outflows, which we attribute to a clumpy or inhomogeneous phase of the disk wind.

40° image intensifier tubes in an integrated helmet system

NASA Astrophysics Data System (ADS)

Schreyer, Herbert; Boehm, Hans-Dieter V.; Svedevall, B.

1993-12-01

EUROCOPTER has been under contract to the French and German ministries of defence for five years to develop the TIGER, a second generation anti-tank helicopter. A piloting thermal imager has been installed on a steerable platform in the helicopter nose in order to achieve the possibility of flying round the clock. In addition to this sensor, which is sensitive at a wavelength of 10 micrometers , the German side has proposed using an Integrated Helmet System in the PAH 2. This helmet, manufactured by GEC-Marconi Avionics, incorporates two cathode ray tubes (CRT) and two image intensifier tubes which allow the pilot to use an additional sensor in the visible and near infrared spectrum. The electronic part will be built by Teldix. EUROCOPTER DEUTSCHLAND has received the first demonstrator of this helmet for testing in the EUROCOPTER Visionics Laboratory. Later, the C-prototype will be integrated into a BK 117 helicopter (AVT Avionik Versuchstrager). This new helmet has a field of view of 40 degree(s), and exit pupil of 15 mm and improved possibilities of adjusting the optical part. Laboratory tests have been carried out to test important parameters like optical resolution under low light level conditions, field of view, eye relief or exit pupil. The CRT channels have been tested for resolution, distortion, vignetting and homogeneity. The requirements and the properties of the helmet, test procedures and the results of these tests are presented in the paper.

On-demand calibration and evaluation for electromagnetically tracked laparoscope in augmented reality visualization.

PubMed

Liu, Xinyang; Plishker, William; Zaki, George; Kang, Sukryool; Kane, Timothy D; Shekhar, Raj

2016-06-01

Common camera calibration methods employed in current laparoscopic augmented reality systems require the acquisition of multiple images of an entire checkerboard pattern from various poses. This lengthy procedure prevents performing laparoscope calibration in the operating room (OR). The purpose of this work was to develop a fast calibration method for electromagnetically (EM) tracked laparoscopes, such that the calibration can be performed in the OR on demand. We designed a mechanical tracking mount to uniquely and snugly position an EM sensor to an appropriate location on a conventional laparoscope. A tool named fCalib was developed to calibrate intrinsic camera parameters, distortion coefficients, and extrinsic parameters (transformation between the scope lens coordinate system and the EM sensor coordinate system) using a single image that shows an arbitrary portion of a special target pattern. For quick evaluation of calibration results in the OR, we integrated a tube phantom with fCalib prototype and overlaid a virtual representation of the tube on the live video scene. We compared spatial target registration error between the common OpenCV method and the fCalib method in a laboratory setting. In addition, we compared the calibration re-projection error between the EM tracking-based fCalib and the optical tracking-based fCalib in a clinical setting. Our results suggest that the proposed method is comparable to the OpenCV method. However, changing the environment, e.g., inserting or removing surgical tools, might affect re-projection accuracy for the EM tracking-based approach. Computational time of the fCalib method averaged 14.0 s (range 3.5 s-22.7 s). We developed and validated a prototype for fast calibration and evaluation of EM tracked conventional (forward viewing) laparoscopes. The calibration method achieved acceptable accuracy and was relatively fast and easy to be performed in the OR on demand.

A novel fully integrated handheld gamma camera

NASA Astrophysics Data System (ADS)

Massari, R.; Ucci, A.; Campisi, C.; Scopinaro, F.; Soluri, A.

2016-10-01

In this paper, we present an innovative, fully integrated handheld gamma camera, namely designed to gather in the same device the gamma ray detector with the display and the embedded computing system. The low power consumption allows the prototype to be battery operated. To be useful in radioguided surgery, an intraoperative gamma camera must be very easy to handle since it must be moved to find a suitable view. Consequently, we have developed the first prototype of a fully integrated, compact and lightweight gamma camera for radiopharmaceuticals fast imaging. The device can operate without cables across the sterile field, so it may be easily used in the operating theater for radioguided surgery. The prototype proposed consists of a Silicon Photomultiplier (SiPM) array coupled with a proprietary scintillation structure based on CsI(Tl) crystals. To read the SiPM output signals, we have developed a very low power readout electronics and a dedicated analog to digital conversion system. One of the most critical aspects we faced designing the prototype was the low power consumption, which is mandatory to develop a battery operated device. We have applied this detection device in the lymphoscintigraphy technique (sentinel lymph node mapping) comparing the results obtained with those of a commercial gamma camera (Philips SKYLight). The results obtained confirm a rapid response of the device and an adequate spatial resolution for the use in the scintigraphic imaging. This work confirms the feasibility of a small gamma camera with an integrated display. This device is designed for radioguided surgery and small organ imaging, but it could be easily combined into surgical navigation systems.

A Self-Powered Fast-Sampling Profiling Float in support of a Mesoscale Ocean Observing System in the Western North Pacific

NASA Astrophysics Data System (ADS)

Valdez, T.; Chao, Y.; Davis, R. E.; Jones, J.

2012-12-01

This talk will describe a new self-powered profiling float that can perform fast sampling over the upper ocean for long durations in support of a mesoscale ocean observing system in the Western North Pacific. The current state-of-the-art profiling floats can provide several hundreds profiles for the upper ocean every ten days. To quantify the role of the upper ocean in modulating the development of Typhoons requires at least an order of magnitude reduction for the sampling interval. With today's profiling float and battery technology, a fast sampling of one day or even a few hours will reduce the typical lifetime of profiling floats from years to months. Interactions between the ocean and typhoons often involves mesoscale eddies and fronts, which require a dense array of floats to reveal the 3-dimensional structure. To measure the mesoscale ocean over a large area like the Western North Pacific therefore requires a new technology that enables fast sampling and long duration at the same time. Harvesting the ocean renewable energy associated with the vertical temperature differentials has the potential to power profiling floats with fast sampling over long durations. Results from the development and deployment of a prototype self-powered profiling float (known as SOLO-TREC) will be presented. With eight hours sampling in the upper 500 meters, the upper ocean temperature and salinity reveal pronounced high frequency variations. Plans to use the SOLO-TREC technology in support of a dense array of fast sampling profiling floats in the Western North Pacific will be discussed.

FPGA-based prototype storage system with phase change memory

NASA Astrophysics Data System (ADS)

Li, Gezi; Chen, Xiaogang; Chen, Bomy; Li, Shunfen; Zhou, Mi; Han, Wenbing; Song, Zhitang

2016-10-01

With the ever-increasing amount of data being stored via social media, mobile telephony base stations, and network devices etc. the database systems face severe bandwidth bottlenecks when moving vast amounts of data from storage to the processing nodes. At the same time, Storage Class Memory (SCM) technologies such as Phase Change Memory (PCM) with unique features like fast read access, high density, non-volatility, byte-addressability, positive response to increasing temperature, superior scalability, and zero standby leakage have changed the landscape of modern computing and storage systems. In such a scenario, we present a storage system called FLEET which can off-load partial or whole SQL queries to the storage engine from CPU. FLEET uses an FPGA rather than conventional CPUs to implement the off-load engine due to its highly parallel nature. We have implemented an initial prototype of FLEET with PCM-based storage. The results demonstrate that significant performance and CPU utilization gains can be achieved by pushing selected query processing components inside in PCM-based storage.

Characterization of the ePix100 prototype: a front-end ASIC for second-generation LCLS integrating hybrid pixel detectors

NASA Astrophysics Data System (ADS)

Caragiulo, P.; Dragone, A.; Markovic, B.; Herbst, R.; Nishimura, K.; Reese, B.; Herrmann, S.; Hart, P.; Blaj, G.; Segal, J.; Tomada, A.; Hasi, J.; Carini, G.; Kenney, C.; Haller, G.

2014-09-01

ePix100 is the first variant of a novel class of integrating pixel ASICs architectures optimized for the processing of signals in second generation LINAC Coherent Light Source (LCLS) X-Ray cameras. ePix100 is optimized for ultra-low noise application requiring high spatial resolution. ePix ASICs are based on a common platform composed of a random access analog matrix of pixel with global shutter, fast parallel column readout, and dedicated sigma-delta analog to digital converters per column. The ePix100 variant has 50μmx50μm pixels arranged in a 352x384 matrix, a resolution of 50e- r.m.s. and a signal range of 35fC (100 photons at 8keV). In its final version it will be able to sustain a frame rate of 1kHz. A first prototype has been fabricated and characterized and the measurement results are reported here.

Precision Timing with shower maximum detectors based on pixelated micro-channel plates

NASA Astrophysics Data System (ADS)

Bornheim, A.; Apresyan, A.; Ronzhin, A.; Xie, S.; Spiropulu, M.; Trevor, J.; Pena, C.; Presutti, F.; Los, S.

2017-11-01

Future calorimeters and shower maximum detectors at high luminosity colliders need to be highly radiation resistant and very fast. One exciting option for such a detector is a calorimeter composed of a secondary emitter as the active element. In this report we outline the study and development of a secondary emission calorimeter prototype using micro-channel plates (MCP) as the active element, which directly amplify the electromagnetic shower signal. We demonstrate the feasibility of using a bare MCP within an inexpensive and robust housing without the need for any photo cathode, which is a key requirement for high radiation tolerance. Test beam measurements of the prototype were performed with 120 GeV primary protons and secondary beams at the Fermilab Test Beam Facility, demonstrating basic calorimetric measurements and precision timing capabilities. Using multiple pixel readout on the MCP, we demonstrate a transverse spatial resolution of 0.8 mm, and time resolution better than 40 ps for electromagnetic showers.

Analog front-end design of the STS/MUCH-XYTER2—full size prototype ASIC for the CBM experiment

NASA Astrophysics Data System (ADS)

Kleczek, Rafal

2017-01-01

The design of the analog front-end of the STS/MUCH-XYTER2 ASIC, a full-size prototype chip for the Silicon Tracking System (STS, based on double-sided silicon strip sensors) and Muon Chamber (MUCH, based on gas sensors) detectors is presented. The ASIC contains 128 charge processing channels, each built of a charge sensitive amplifier, a polarity selection circuit and two pulse shaping amplifiers forming two parallel signal paths. The first path is used for timing measurement with a fast discriminator. The second path allows low-noise amplitude measurement with a 5-bit continuous-time flash ADC. Different operating conditions and constraints posed by two target detectors' applications require front-end electronics flexibility to meet extended system-wise requirements. The presented circuit implements switchable shaper peaking time, gain switching and trimming, input amplifier pulsed reset circuit, fail-safe measures. The power consumption is scalable (for the STS and the MUCH modes), but limited to 10 mW/channel.

Nanobiotechnologic approach to a promising vaccine prototype for immunisation against leishmaniasis: a fast and effective method to incorporate GPI-anchored proteins of Leishmania amazonensis into liposomes.

PubMed

Colhone, Marcelle Carolina; Silva-Jardim, Izaltina; Stabeli, Rodrigo Guerino; Ciancaglini, Pietro

2015-01-01

Liposomes are known to be a potent adjuvant for a wide range of antigens, as well as appropriate antigen carriers for antibody generation response in vivo. In addition, liposomes are effective vehicles for peptides and proteins, thus enhancing their immunogenicity. Considering these properties of liposomes and the antigenicity of the Leishmania membrane proteins, we evaluated if liposomes carrying glycosylphosphatidylinositol (GPI)-anchored proteins of Leishmania amazonensis promastigotes could induce protective immunity in BALB/c mice. To assay protective immunity, BALB/c mice were intraperitoneally injected with liposomes, GPI-protein extract (EPSGPI) as well as with the proteoliposomes carrying GPI-proteins. Mice inoculated with EPSGPI and total protein present in constitutive proteoliposomes displayed a post-infection protection of about 70% and 90%, respectively. The liposomes are able to work as adjuvant in the EPSGPI protection. These systems seem to be a promising vaccine prototype for immunisation against leishmaniasis.

NEN Division Funding Gap Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Esch, Ernst I.; Goettee, Jeffrey D.; Desimone, David J.

The work in NEN Division revolves around proliferation detection. The sponsor funding model seems to have shifted over the last decades. For the past three lustra, sponsors are mainly interested in funding ideas and detection systems that are already at a technical readiness level 6 (TRL 6 -- one step below an industrial prototype) or higher. Once this level is reached, the sponsoring agency is willing to fund the commercialization, implementation, and training for the systems (TRL 8, 9). These sponsors are looking for a fast turnaround (1-2 years) technology development efforts to implement technology. To support the critical nationalmore » and international needs for nonprolifertion solutions, we have to maintain a fluent stream of subject matter expertise from the fundamental principals of radiation detection through prototype development all the way to the implementation and training of others. NEN Division has large funding gaps in the Valley of Death region. In the current competitive climate for nuclear nonproliferation projects, it is imminent to increase our lead in this field.« less

Development of a Protocol for Automated Glucose Measurement Transmission Used in Clinical Decision Support Systems Based on the Continua Design Guidelines.

PubMed

Meyer, Markus; Donsa, Klaus; Truskaller, Thomas; Frohner, Matthias; Pohn, Birgit; Felfernig, Alexander; Sinner, Frank; Pieber, Thomas

2018-01-01

A fast and accurate data transmission from glucose meter to clinical decision support systems (CDSSs) is crucial for the management of type 2 diabetes mellitus since almost all therapeutic interventions are derived from glucose measurements. Aim was to develop a prototype of an automated glucose measurement transmission protocol based on the Continua Design Guidelines and to embed the protocol into a CDSS used by healthcare professionals. A literature and market research was performed to analyze the state-of-the-art and thereupon develop, integrate and validate an automated glucose measurement transmission protocol in an iterative process. Findings from literature and market research guided towards the development of a standardized glucose measurement transmission protocol using a middleware. The interface description to communicate with the glucose meter was illustrated and embedded into a CDSS. A prototype of an interoperable transmission of glucose measurements was developed and implemented in a CDSS presenting a promising way to reduce medication errors and improve user satisfaction.

Galileo Galilei (GG): the space mission and the prototype

NASA Astrophysics Data System (ADS)

Nobili, A.

"GALILEO GALILEI (GG)" is a proposal to fly a small satellite in low Earth orbit aiming to test the Equivalence Principle of Galileo, Newton and Einstein to 1 part in 1017 at room temperature. Ground tests carried out with artificial test bodies on rotating torsion balances, and tests with celestial bodies based on Lunar Laser Ranging data, have found no violation to about 1 part in 1013 . Competing space pro jects are SCOPE (also at room temperature) aiming to 1 part in 1015 , and STEP (at very low temperature) aiming to 1 part in 1018 . GG is characterized by fast rotation and by the possibility to perform a full scale test on the ground. This talk will present the main features of the GG design, as compared to STEP and SCOPE, and report the experimental results obtained with the first and the second generation laboratory prototypes (natural frequencies, quality factor, stability, sensitivity). Interested scientists are welcome to visit the GG webpage at http://eotvos.dm.unipi.it/nobili.

Precision Timing with shower maximum detectors based on pixelated micro-channel plates

DOE PAGES

Bornheim, A.; Apresyan, A.; Ronzhin, A.; ...

2017-11-27

Future calorimeters and shower maximum detectors at high luminosity colliders need to be highly radiation resistant and very fast. One exciting option for such a detector is a calorimeter composed of a secondary emitter as the active element. Here, we outline the study and development of a secondary emission calorimeter prototype using micro-channel plates (MCP) as the active element, which directly amplify the electromagnetic shower signal. We also demonstrate the feasibility of using a bare MCP within an inexpensive and robust housing without the need for any photo cathode, which is a key requirement for high radiation tolerance. Test beammore » measurements of the prototype were performed with 120 GeV primary protons and secondary beams at the Fermilab Test Beam Facility, demonstrating basic calorimetric measurements and precision timing capabilities. Using multiple pixel readout on the MCP, we demonstrate a transverse spatial resolution of 0.8 mm, and time resolution better than 40 ps for electromagnetic showers.« less

Morpheus Lander Testing Campaign

NASA Technical Reports Server (NTRS)

Hart, Jeremy J.; Mitchell, Jennifer D.

2011-01-01

NASA s Morpheus Project has developed and tested a prototype planetary lander capable of vertical takeoff and landing designed to serve as a testbed for advanced spacecraft technologies. The Morpheus vehicle has successfully performed a set of integrated vehicle test flights including hot-fire and tether tests, ultimately culminating in an un-tethered "free-flight" This development and testing campaign was conducted on-site at the Johnson Space Center (JSC), less than one year after project start. Designed, developed, manufactured and operated in-house by engineers at JSC, the Morpheus Project represents an unprecedented departure from recent NASA programs and projects that traditionally require longer development lifecycles and testing at remote, dedicated testing facilities. This paper documents the integrated testing campaign, including descriptions of test types (hot-fire, tether, and free-flight), test objectives, and the infrastructure of JSC testing facilities. A major focus of the paper will be the fast pace of the project, rapid prototyping, frequent testing, and lessons learned from this departure from the traditional engineering development process at NASA s Johnson Space Center.

Smart Aerospace eCommerce: Using Intelligent Agents in a NASA Mission Services Ordering Application

NASA Technical Reports Server (NTRS)

Moleski, Walt; Luczak, Ed; Morris, Kim; Clayton, Bill; Scherf, Patricia; Obenschain, Arthur F. (Technical Monitor)

2002-01-01

This paper describes how intelligent agent technology was successfully prototyped and then deployed in a smart eCommerce application for NASA. An intelligent software agent called the Intelligent Service Validation Agent (ISVA) was added to an existing web-based ordering application to validate complex orders for spacecraft mission services. This integration of intelligent agent technology with conventional web technology satisfies an immediate NASA need to reduce manual order processing costs. The ISVA agent checks orders for completeness, consistency, and correctness, and notifies users of detected problems. ISVA uses NASA business rules and a knowledge base of NASA services, and is implemented using the Java Expert System Shell (Jess), a fast rule-based inference engine. The paper discusses the design of the agent and knowledge base, and the prototyping and deployment approach. It also discusses future directions and other applications, and discusses lessons-learned that may help other projects make their aerospace eCommerce applications smarter.

Precision Timing with shower maximum detectors based on pixelated micro-channel plates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bornheim, A.; Apresyan, A.; Ronzhin, A.

Future calorimeters and shower maximum detectors at high luminosity colliders need to be highly radiation resistant and very fast. One exciting option for such a detector is a calorimeter composed of a secondary emitter as the active element. Here, we outline the study and development of a secondary emission calorimeter prototype using micro-channel plates (MCP) as the active element, which directly amplify the electromagnetic shower signal. We also demonstrate the feasibility of using a bare MCP within an inexpensive and robust housing without the need for any photo cathode, which is a key requirement for high radiation tolerance. Test beammore » measurements of the prototype were performed with 120 GeV primary protons and secondary beams at the Fermilab Test Beam Facility, demonstrating basic calorimetric measurements and precision timing capabilities. Using multiple pixel readout on the MCP, we demonstrate a transverse spatial resolution of 0.8 mm, and time resolution better than 40 ps for electromagnetic showers.« less

From impedance theory to needle electrode guidance in tissue

NASA Astrophysics Data System (ADS)

Kalvøy, Håvard; Høyum, Per; Grimnes, Sverre; Martinsen, Ørjan G.

2010-04-01

Fast access to blood vessels or other tissues/organs can be crucial in clinical or acute medical treatment. We have developed a method for needle guidance for use in different types of applications. The feasibility of an automatic application for fast access to blood vessels during acute cardiac arrest, based on this method, has been evaluated. Suited electrode setups were found by development of needle electrode models used in simulation and sensitivity analyses. In vitro measurements were done both to determine the fundamental properties of the electrodes for use in the models and to confirm the simulation results. Development of algorithms for tissue characterization and differentiation was based on in vivo impedance measurement in porcine models and confirmed in human tissue in vivo. Feasibility was proven by application prototyping and impedance data presented as invasive Electrical Impedance Tomography (iEIT). Our conclusion is that this method can be utilized in a wide range of clinical applications.

Temperature dependence of the response of ultra fast silicon detectors

NASA Astrophysics Data System (ADS)

Mulargia, R.; Arcidiacono, R.; Bellora, A.; Boscardin, M.; Cartiglia, N.; Cenna, F.; Cirio, R.; Dalla Betta, G. F.; Durando, S.; Fadavi, A.; Ferrero, M.; Galloway, Z.; Gruey, B.; Freeman, P.; Kramberger, G.; Mandic, I.; Monaco, V.; Obertino, M.; Pancheri, L.; Paternoster, G.; Ravera, F.; Sacchi, R.; Sadrozinski, H. F. W.; Seiden, A.; Sola, V.; Spencer, N.; Staiano, A.; Wilder, M.; Woods, N.; Zatserklyaniy, A.

2016-12-01

The Ultra Fast Silicon Detectors (UFSD) are a novel concept of silicon detectors based on the Low Gain Avalanche Diode (LGAD) technology, which are able to obtain time resolution of the order of few tens of picoseconds. First prototypes with different geometries (pads/pixels/strips), thickness (300 and 50 μm) and gain (between 5 and 20) have been recently designed and manufactured by CNM (Centro Nacional de Microelectrónica, Barcelona) and FBK (Fondazione Bruno Kessler, Trento). Several measurements on these devices have been performed in laboratory and in beam test and a dependence of the gain on the temperature has been observed. Some of the first measurements will be shown (leakage current, breakdown voltage, gain and time resolution on the 300 μm from FBK and gain on the 50 μm-thick sensor from CNM) and a comparison with the theoretically predicted trend will be discussed.

Modeling scintillator and WLS fiber signals for fast Monte Carlo simulations

NASA Astrophysics Data System (ADS)

Sánchez, F. A.; Medina-Tanco, G.

2010-08-01

In this work we present a fast, robust and flexible procedure to simulate electronic signals of scintillator units: plastic scintillator material embedded with a wavelength shifter optical fiber coupled to a photo-multiplier tube which, in turn, is plugged to a front-end electronic board. The simple rationale behind the simulation chain allows to adapt the procedure to a broad range of detectors based on that kind of units. We show that, in order to produce realistic results, the simulation parameters can be properly calibrated against laboratory measurements and used thereafter as input of the simulations. Simulated signals of atmospheric background cosmic ray muons are presented and their main features analyzed and validated using actual measured data. Conversely, for any given practical application, the present simulation scheme can be used to find an adequate combination of photo-multiplier tube and optical fiber at the prototyping stage.

Irradiation performance of PFBR MOX fuel after 112 GWd/t burn-up

NASA Astrophysics Data System (ADS)

Venkiteswaran, C. N.; Jayaraj, V. V.; Ojha, B. K.; Anandaraj, V.; Padalakshmi, M.; Vinodkumar, S.; Karthik, V.; Vijaykumar, Ran; Vijayaraghavan, A.; Divakar, R.; Johny, T.; Joseph, Jojo; Thirunavakkarasu, S.; Saravanan, T.; Philip, John; Rao, B. P. C.; Kasiviswanathan, K. V.; Jayakumar, T.

2014-06-01

The 500 MWe Prototype Fast Breeder Reactor (PFBR) which is in advanced stage of construction at Kalpakkam, India, will use mixed oxide (MOX) fuel with a target burnup of 100 GWd/t. The fuel pellet is of annular design to enable operation at a peak linear power of 450 W/cm with the requirement of minimum duration of pre-conditioning. The performance of the MOX fuel and the D9 clad and wrapper material was assessed through Post Irradiation Examinations (PIE) after test irradiation of 37 fuel pin subassembly in Fast Breeder Test Reactor (FBTR) to a burn-up of 112 GWd/t. Fission product distribution, swelling and fuel-clad gap evolution, central hole diameter variation, restructuring, fission gas release and clad wastage due to fuel-clad chemical interaction were evaluated through non-destructive and destructive examinations. The examinations have indicated that the MOX fuel can safely attain the desired target burn-up in PFBR.

Timing in a FLASH

NASA Astrophysics Data System (ADS)

Hoek, M.; Cardinali, M.; Corell, O.; Dickescheid, M.; Ferretti B., M. I.; Lauth, W.; Schlimme, B. S.; Sfienti, C.; Thiel, M.

2017-12-01

A prototype detector, called FLASH (Fast Light Acquiring Start Hodoscope), was built to provide precise Time-of-Flight (TOF) measurements and reference timestamps for detector setups at external beam lines. Radiator bars, made of synthetic fused silica, were coupled to a fast MCP-PMT with 64 channels and read out with custom electronics using Time-over-Threshold (TOT) for signal characterization. The TRB3 system, a high-precision TDC implemented in an FPGA, was used as data acquisition system. The performance of a system consisting of two FLASH units was investigated at a dedicated test experiment at the Mainz Microtron (MAMI) accelerator using its 855 MeV electron beam. The TOT measurement enabled time walk corrections and an overall TOF resolution of ∼70 ps could be achieved which translates into a resolution of ∼50 ps per FLASH unit. The intrinsic resolution of the frontend electronics including the TDC was measured to be less than 25 ps.

Advanced Fast 3-D Electromagnetic Solver for Microwave Tomography Imaging.

PubMed

Simonov, Nikolai; Kim, Bo-Ra; Lee, Kwang-Jae; Jeon, Soon-Ik; Son, Seong-Ho

2017-10-01

This paper describes a fast-forward electromagnetic solver (FFS) for the image reconstruction algorithm of our microwave tomography system. Our apparatus is a preclinical prototype of a biomedical imaging system, designed for the purpose of early breast cancer detection. It operates in the 3-6-GHz frequency band using a circular array of probe antennas immersed in a matching liquid; it produces image reconstructions of the permittivity and conductivity profiles of the breast under examination. Our reconstruction algorithm solves the electromagnetic (EM) inverse problem and takes into account the real EM properties of the probe antenna array as well as the influence of the patient's body and that of the upper metal screen sheet. This FFS algorithm is much faster than conventional EM simulation solvers. In comparison, in the same PC, the CST solver takes ~45 min, while the FFS takes ~1 s of effective simulation time for the same EM model of a numerical breast phantom.

The PANDA DIRC detectors at FAIR

NASA Astrophysics Data System (ADS)

Schwarz, C.; Ali, A.; Belias, A.; Dzhygadlo, R.; Gerhardt, A.; Götzen, K.; Kalicy, G.; Krebs, M.; Lehmann, D.; Nerling, F.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwiening, J.; Traxler, M.; Zühlsdorf, M.; Böhm, M.; Britting, A.; Eyrich, W.; Lehmann, A.; Pfaffinger, M.; Uhlig, F.; Düren, M.; Etzelmüller, E.; Föhl, K.; Hayrapetyan, A.; Kreutzfeld, K.; Kröck, B.; Merle, O.; Rieke, J.; Schmidt, M.; Wasem, T.; Achenbach, P.; Cardinali, M.; Hoek, M.; Lauth, W.; Schlimme, S.; Sfienti, C.; Thiel, M.; Allison, L.; Hyde, C.

2017-07-01

The PANDA detector at the international accelerator Facility for Antiproton and Ion Research in Europe (FAIR) addresses fundamental questions of hadron physics. An excellent hadronic particle identification (PID) will be accomplished by two DIRC (Detection of Internally Reflected Cherenkov light) counters in the target spectrometer. The design for the barrel region covering polar angles between 22o to 140o is based on the successful BABAR DIRC with several key improvements, such as fast photon timing and a compact imaging region. The novel Endcap Disc DIRC will cover the smaller forward angles between 5o (10o) to 22o in the vertical (horizontal) direction. Both DIRC counters will use lifetime-enhanced microchannel plate PMTs for photon detection in combination with fast readout electronics. Geant4 simulations and tests with several prototypes at various beam facilities have been used to evaluate the designs and validate the expected PID performance of both PANDA DIRC counters.

Fast calculation method for computer-generated cylindrical holograms.

PubMed

Yamaguchi, Takeshi; Fujii, Tomohiko; Yoshikawa, Hiroshi

2008-07-01

Since a general flat hologram has a limited viewable area, we usually cannot see the other side of a reconstructed object. There are some holograms that can solve this problem. A cylindrical hologram is well known to be viewable in 360 deg. Most cylindrical holograms are optical holograms, but there are few reports of computer-generated cylindrical holograms. The lack of computer-generated cylindrical holograms is because the spatial resolution of output devices is not great enough; therefore, we have to make a large hologram or use a small object to fulfill the sampling theorem. In addition, in calculating the large fringe, the calculation amount increases in proportion to the hologram size. Therefore, we propose what we believe to be a new calculation method for fast calculation. Then, we print these fringes with our prototype fringe printer. As a result, we obtain a good reconstructed image from a computer-generated cylindrical hologram.

Fast-neutron/gamma-ray radiography scanner for the detection of contraband in air cargo containers

NASA Astrophysics Data System (ADS)

Eberhardt, J.; Liu, Y.; Rainey, S.; Roach, G.; Sowerby, B.; Stevens, R.; Tickner, J.

2006-05-01

There is a worldwide need for efficient inspection of cargo containers at airports, seaports and road border crossings. The main objectives are the detection of contraband such as illicit drugs, explosives and weapons. Due to the large volume of cargo passing through Australia's airports every day, it is critical that any scanning system should be capable of working on unpacked or consolidated cargo, taking at most 1-2 minutes per container. CSIRO has developed a fast-neutron/gamma-ray radiography (FNGR) method for the rapid screening of air freight. By combining radiographs obtained using 14 MeV neutrons and 60Co gamma-rays, high resolution images showing both density and material composition are obtained. A near full-scale prototype scanner has been successfully tested in the laboratory. With the support of the Australian Customs Service, a full-scale scanner has recently been installed and commissioned at Brisbane International Airport.

Unbiased free energy estimates in fast nonequilibrium transformations using Gaussian mixtures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Procacci, Piero

2015-04-21

In this paper, we present an improved method for obtaining unbiased estimates of the free energy difference between two thermodynamic states using the work distribution measured in nonequilibrium driven experiments connecting these states. The method is based on the assumption that any observed work distribution is given by a mixture of Gaussian distributions, whose normal components are identical in either direction of the nonequilibrium process, with weights regulated by the Crooks theorem. Using the prototypical example for the driven unfolding/folding of deca-alanine, we show that the predicted behavior of the forward and reverse work distributions, assuming a combination of onlymore » two Gaussian components with Crooks derived weights, explains surprisingly well the striking asymmetry in the observed distributions at fast pulling speeds. The proposed methodology opens the way for a perfectly parallel implementation of Jarzynski-based free energy calculations in complex systems.« less

Courthouse Prototype Building

DOE Office of Scientific and Technical Information (OSTI.GOV)

Malhotra, Mini; New, Joshua Ryan; Im, Piljae

As part of DOE's support of ANSI/ASHRAE/IES Standard 90.1 and IECC, researchers at Pacific Northwest National Laboratory (PNNL) apply a suite of prototype buildings covering 80% of the commercial building floor area in the U.S. for new construction. Efforts have started on expanding the prototype building suite to cover 90% of the commercial building floor area in the U.S., by developing prototype models for additional building types including place of worship, public order and safety, public assembly. Courthouse is courthouse is a sub-category under the “Public Order and Safety" building type category; other sub-categories include police station, fire station, andmore » jail, reformatory or penitentiary.ORNL used building design guides, databases, and documented courthouse projects, supplemented by personal communication with courthouse facility planning and design experts, to systematically conduct research on the courthouse building and system characteristics. This report documents the research conducted for the courthouse building type and proposes building and system characteristics for developing a prototype building energy model to be included in the Commercial Building Prototype Model suite. According to the 2012 CBECS, courthouses occupy a total of 436 million sqft of floor space or 0.5% of the total floor space in all commercial buildings in the US, next to fast food (0.35%), grocery store or food market (0.88%), and restaurant or cafeteria (1.2%) building types currently included in the Commercial Prototype Building Model suite. Considering aggregated average, courthouse falls among the larger with a mean floor area of 69,400 sqft smaller fuel consumption intensity building types and an average of 94.7 kBtu/sqft compared to 77.8 kBtu/sqft for office and 80 kBtu/sqft for all commercial buildings.Courthouses range in size from 1000 sqft to over a million square foot building gross square feet and 1 courtroom to over 100 courtrooms. Small courthouses represent a majority of courthouse buildings. However, collectively they comprise a small fraction of total courthouse floor area in the US. Spaces and operation of courthouse also varies depending on the court type (federal court vs state court; district, appellate, versus Supreme Court) and jurisdiction (general jurisdiction, general jurisdiction trial, or special courts). Based on the statistics on courthouses, general jurisdiction trial court is considered for the prototype model. The model is assumed to be a 4-courtroom, small, 72,000 sqft three-story building including a ground level/ basement.« less

META-GLARE: a shell for CIG systems.

PubMed

Bottrighi, Alessio; Rubrichi, Stefania; Terenziani, Paolo

2015-01-01

In the last twenty years, many different approaches to deal with Computer-Interpretable clinical Guidelines (CIGs) have been developed, each one proposing its own representation formalism (mostly based on the Task-Network Model) execution engine. We propose META-GLARE a shell for easily defining new CIG systems. Using META-GLARE, CIG system designers can easily define their own systems (basically by defining their representation language), with a minimal programming effort. META-GLARE is thus a flexible and powerful vehicle for research about CIGs, since it supports easy and fast prototyping of new CIG systems.

High voltage-high power components for large space power distribution systems

NASA Technical Reports Server (NTRS)

Renz, D. D.

1984-01-01

Space power components including a family of bipolar power switching transistors, fast switching power diodes, heat pipe cooled high frequency transformers and inductors, high frequency conduction cooled transformers, high power-high frequency capacitors, remote power controllers and rotary power transfer devices were developed. Many of these components such as the power switching transistors, power diodes and the high frequency capacitor are commercially available. All the other components were developed to the prototype level. The dc/dc series resonant converters were built to the 25 kW level.

LAPACKrc: Fast linear algebra kernels/solvers for FPGA accelerators

NASA Astrophysics Data System (ADS)

Gonzalez, Juan; Núñez, Rafael C.

2009-07-01

We present LAPACKrc, a family of FPGA-based linear algebra solvers able to achieve more than 100x speedup per commodity processor on certain problems. LAPACKrc subsumes some of the LAPACK and ScaLAPACK functionalities, and it also incorporates sparse direct and iterative matrix solvers. Current LAPACKrc prototypes demonstrate between 40x-150x speedup compared against top-of-the-line hardware/software systems. A technology roadmap is in place to validate current performance of LAPACKrc in HPC applications, and to increase the computational throughput by factors of hundreds within the next few years.

Fabrication of capsule assemblies, phase 3

NASA Technical Reports Server (NTRS)

Keeton, A. R.; Stemann, L. G.

1973-01-01

Thirteen capsule assemblies were fabricated for evaluation of fuel pin design concepts for a fast spectrum lithium cooled compact space power reactor. These instrumented assemblies were designed for real time test of prototype fuel pins. Uranium mononitride fuel pins were encased in AISI 304L stainless steel capsules. Fabrication procedures were fully qualified by process development and assembly qualification tests. Instrumentation reliability was achieved utilizing specially processed and closely controlled thermocouple hot zone fabrication and by thermal screening tests. Overall capsule reliability was achieved with an all electron beam welded assembly.

Model-based engineering for medical-device software.

PubMed

Ray, Arnab; Jetley, Raoul; Jones, Paul L; Zhang, Yi

2010-01-01

This paper demonstrates the benefits of adopting model-based design techniques for engineering medical device software. By using a patient-controlled analgesic (PCA) infusion pump as a candidate medical device, the authors show how using models to capture design information allows for i) fast and efficient construction of executable device prototypes ii) creation of a standard, reusable baseline software architecture for a particular device family, iii) formal verification of the design against safety requirements, and iv) creation of a safety framework that reduces verification costs for future versions of the device software. 1.

Next generation data harmonization

NASA Astrophysics Data System (ADS)

Armstrong, Chandler; Brown, Ryan M.; Chaves, Jillian; Czerniejewski, Adam; Del Vecchio, Justin; Perkins, Timothy K.; Rudnicki, Ron; Tauer, Greg

2015-05-01

Analysts are presented with a never ending stream of data sources. Often, subsets of data sources to solve problems are easily identified but the process to align data sets is time consuming. However, many semantic technologies do allow for fast harmonization of data to overcome these problems. These include ontologies that serve as alignment targets, visual tools and natural language processing that generate semantic graphs in terms of the ontologies, and analytics that leverage these graphs. This research reviews a developed prototype that employs all these approaches to perform analysis across disparate data sources documenting violent, extremist events.

[Preoperative fasting period of fluids in bariatric surgery].

PubMed

Simon, P; Pietsch, U-C; Oesemann, R; Dietrich, A; Wrigge, H

2017-07-01

Aspiration of stomach content is a severe complication during general anaesthesia. The DGAI (German Society for Anesthesiology and Intensive Care Medicine) guidelines recommend a fasting period for liquids of 2 h, with a maximum of 400 ml. Preoperative fasting can affect the patients' recovery after surgery due to insulin resistance and higher protein catabolism as a response to surgical stress. The aim of the study was to compare a liberal fasting regimen consisting of up to 1000 ml of liquids until 2 h before surgery with the DGAI recommendation. The prospective observational clinical study was approved by the ethics committee of the University of Leipzig. In the liberal fasting group (G lib ) patients undergoing bariatric surgery were asked to drink 1000 ml of tea up to 2 h before surgery. Patients assigned to the restrictive fasting group (G res ) who were undergoing nonbariatric abdominal surgery were asked to drink no more than 400 ml of water up to 2 h preoperatively. Right after anaesthesia induction and intubation a gastric tube was placed, gastric residual volume was measured and the pH level of gastric fluid was determined. Moreover, the occurrence of aspiration was monitored. In all, 98 patients with a body mass index (BMI) of G lib 51.1 kg/m 2 and G res 26.5 kg/m 2 were identified. The preoperative fasting period of liquids was significantly different (G lib 170 min vs. G res 700 min, p < 0.001). There was no difference regarding the residual gastric volume (G lib 11 ml, G res 5 ml, p = 0.355). The pH of gastric fluid was nearly similar (G lib  4.0; G res  3.0; p = 0.864). Aspiration did not occur in any patient. There is evidence suggesting that a liberal fluid fasting regimen (1000 ml of fluid) in the preoperative period is safe in patients undergoing bariatric surgery.

Size scaling of negative hydrogen ion sources for fusion

NASA Astrophysics Data System (ADS)

Fantz, U.; Franzen, P.; Kraus, W.; Schiesko, L.; Wimmer, C.; Wünderlich, D.

2015-04-01

The RF-driven negative hydrogen ion source (H-, D-) for the international fusion experiment ITER has a width of 0.9 m and a height of 1.9 m and is based on a ⅛ scale prototype source being in operation at the IPP test facilities BATMAN and MANITU for many years. Among the challenges to meet the required parameters in a caesiated source at a source pressure of 0.3 Pa or less is the challenge in size scaling of a factor of eight. As an intermediate step a ½ scale ITER source went into operation at the IPP test facility ELISE with the first plasma in February 2013. The experience and results gained so far at ELISE allowed a size scaling study from the prototype source towards the ITER relevant size at ELISE, in which operational issues, physical aspects and the source performance is addressed, highlighting differences as well as similarities. The most ITER relevant results are: low pressure operation down to 0.2 Pa is possible without problems; the magnetic filter field created by a current in the plasma grid is sufficient to reduce the electron temperature below the target value of 1 eV and to reduce together with the bias applied between the differently shaped bias plate and the plasma grid the amount of co-extracted electrons. An asymmetry of the co-extracted electron currents in the two grid segments is measured, varying strongly with filter field and bias. Contrary to the prototype source, a dedicated plasma drift in vertical direction is not observed. As in the prototype source, the performance in deuterium is limited by the amount of co-extracted electrons in short as well as in long pulse operation. Caesium conditioning is much harder in deuterium than in hydrogen for which fast and reproducible conditioning is achieved. First estimates reveal a caesium consumption comparable to the one in the prototype source despite the large size.

SMART precision cancer medicine: a FHIR-based app to provide genomic information at the point of care.

PubMed

Warner, Jeremy L; Rioth, Matthew J; Mandl, Kenneth D; Mandel, Joshua C; Kreda, David A; Kohane, Isaac S; Carbone, Daniel; Oreto, Ross; Wang, Lucy; Zhu, Shilin; Yao, Heming; Alterovitz, Gil

2016-07-01

Precision cancer medicine (PCM) will require ready access to genomic data within the clinical workflow and tools to assist clinical interpretation and enable decisions. Since most electronic health record (EHR) systems do not yet provide such functionality, we developed an EHR-agnostic, clinico-genomic mobile app to demonstrate several features that will be needed for point-of-care conversations. Our prototype, called Substitutable Medical Applications and Reusable Technology (SMART)® PCM, visualizes genomic information in real time, comparing a patient's diagnosis-specific somatic gene mutations detected by PCR-based hotspot testing to a population-level set of comparable data. The initial prototype works for patient specimens with 0 or 1 detected mutation. Genomics extensions were created for the Health Level Seven® Fast Healthcare Interoperability Resources (FHIR)® standard; otherwise, the prototype is a normal SMART on FHIR app. The PCM prototype can rapidly present a visualization that compares a patient's somatic genomic alterations against a distribution built from more than 3000 patients, along with context-specific links to external knowledge bases. Initial evaluation by oncologists provided important feedback about the prototype's strengths and weaknesses. We added several requested enhancements and successfully demonstrated the app at the inaugural American Society of Clinical Oncology Interoperability Demonstration; we have also begun to expand visualization capabilities to include cancer specimens with multiple mutations. PCM is open-source software for clinicians to present the individual patient within the population-level spectrum of cancer somatic mutations. The app can be implemented on any SMART on FHIR-enabled EHRs, and future versions of PCM should be able to evolve in parallel with external knowledge bases. © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Performance of In-Pixel Circuits for Photon Counting Arrays (PCAs) Based on Polycrystalline Silicon TFTs

PubMed Central

Liang, Albert K.; Koniczek, Martin; Antonuk, Larry E.; El-Mohri, Youcef; Zhao, Qihua; Street, Robert A.; Lu, Jeng Ping

2017-01-01

Photon counting arrays (PCAs), defined as pixelated imagers which measure the absorbed energy of x-ray photons individually and record this information digitally, are of increasing clinical interest. A number of PCA prototypes with a 1 mm pixel-to-pixel pitch have recently been fabricated with polycrystalline silicon (poly-Si) — a thin-film technology capable of creating monolithic imagers of a size commensurate with human anatomy. In this study, analog and digital simulation frameworks were developed to provide insight into the influence of individual poly-Si transistors on pixel circuit performance — information that is not readily available through empirical means. The simulation frameworks were used to characterize the circuit designs employed in the prototypes. The analog framework, which determines the noise produced by individual transistors, was used to estimate energy resolution, as well as to identify which transistors contribute the most noise. The digital framework, which analyzes how well circuits function in the presence of significant variations in transistor properties, was used to estimate how fast a circuit can produce an output (referred to as output count rate). In addition, an algorithm was developed and used to estimate the minimum pixel pitch that could be achieved for the pixel circuits of the current prototypes. The simulation frameworks predict that the analog component of the PCA prototypes could have energy resolution as low as 8.9% FWHM at 70 keV; and the digital components should work well even in the presence of significant TFT variations, with the fastest component having output count rates as high as 3 MHz. Finally, based on conceivable improvements in the underlying fabrication process, the algorithm predicts that the 1 mm pitch of the current PCA prototypes could be reduced significantly, potentially to between ~240 and 290 μm. PMID:26878107

Performance of in-pixel circuits for photon counting arrays (PCAs) based on polycrystalline silicon TFTs.

PubMed

Liang, Albert K; Koniczek, Martin; Antonuk, Larry E; El-Mohri, Youcef; Zhao, Qihua; Street, Robert A; Lu, Jeng Ping

2016-03-07

Photon counting arrays (PCAs), defined as pixelated imagers which measure the absorbed energy of x-ray photons individually and record this information digitally, are of increasing clinical interest. A number of PCA prototypes with a 1 mm pixel-to-pixel pitch have recently been fabricated with polycrystalline silicon (poly-Si)-a thin-film technology capable of creating monolithic imagers of a size commensurate with human anatomy. In this study, analog and digital simulation frameworks were developed to provide insight into the influence of individual poly-Si transistors on pixel circuit performance-information that is not readily available through empirical means. The simulation frameworks were used to characterize the circuit designs employed in the prototypes. The analog framework, which determines the noise produced by individual transistors, was used to estimate energy resolution, as well as to identify which transistors contribute the most noise. The digital framework, which analyzes how well circuits function in the presence of significant variations in transistor properties, was used to estimate how fast a circuit can produce an output (referred to as output count rate). In addition, an algorithm was developed and used to estimate the minimum pixel pitch that could be achieved for the pixel circuits of the current prototypes. The simulation frameworks predict that the analog component of the PCA prototypes could have energy resolution as low as 8.9% full width at half maximum (FWHM) at 70 keV; and the digital components should work well even in the presence of significant thin-film transistor (TFT) variations, with the fastest component having output count rates as high as 3 MHz. Finally, based on conceivable improvements in the underlying fabrication process, the algorithm predicts that the 1 mm pitch of the current PCA prototypes could be reduced significantly, potentially to between ~240 and 290 μm.

German Emergency Care in Neurosurgery and Military Neurology during World War II, 1939-1945.

PubMed

Stahnisch, Frank W

2016-01-01

A critical analysis of the historical involvement of neurology and neurosurgery in military emergency care services enables us to better contextualize and appreciate the development of modern neurology at large. Wartime neurosurgery and civil brain science during the German Nazi period tightly coalesced in examining the specific injury types, which military neurosurgeons such as Wilhelm Toennis, Klaus Joachim Zuelch, and Georg Merrem encountered and treated based on their neurophysiological understanding gained from earlier peacetime research. Collaborative associations with Dr. Toennis in particular proved to be highly beneficial to other military neurologists and neurosurgeons during World War II and beyond. This article also discusses the prewar developments and considers the fate of German neurosurgeons and military neurologists after the war. The envisaged dynamic concepts of fast action, reaction, and recycling, which contemporary physicians had intensively studied in the preceding scientific experiments in their neurophysiological laboratories, had already been introduced into neurological surgery during the interwar period. In retrospect, World War II emergency rescue units greatly strengthened military operations through an active process of 'recycling' indispensable army personnel. Neurosurgical emergency chains thereby introduced another decisive step in the modernization of warfare, in that they increased the momentum of military mobility in the field. Notwithstanding the violence of warfare and the often inhumane ways in which such knowledge in the field of emergency neurology was gained, the protagonists among the group of experts in military neurology and neurosurgery strongly contributed to the postwar clinical neuroscience community in Germany. In differing political pretexts, this became visible in both East Germany and West Germany after the war, while the specific military and political conditions under which this knowledge of emergency medicine was obtained have largely been forgotten. © 2016 S. Karger AG, Basel.

A Compute Capable SSD Architecture for Next-Generation Non-volatile Memories

DOE Office of Scientific and Technical Information (OSTI.GOV)

De, Arup

2014-01-01

Existing storage technologies (e.g., disks and ash) are failing to cope with the processor and main memory speed and are limiting the overall perfor- mance of many large scale I/O or data-intensive applications. Emerging fast byte-addressable non-volatile memory (NVM) technologies, such as phase-change memory (PCM), spin-transfer torque memory (STTM) and memristor are very promising and are approaching DRAM-like performance with lower power con- sumption and higher density as process technology scales. These new memories are narrowing down the performance gap between the storage and the main mem- ory and are putting forward challenging problems on existing SSD architecture, I/O interfacemore » (e.g, SATA, PCIe) and software. This dissertation addresses those challenges and presents a novel SSD architecture called XSSD. XSSD o oads com- putation in storage to exploit fast NVMs and reduce the redundant data tra c across the I/O bus. XSSD o ers a exible RPC-based programming framework that developers can use for application development on SSD without dealing with the complication of the underlying architecture and communication management. We have built a prototype of XSSD on the BEE3 FPGA prototyping system. We implement various data-intensive applications and achieve speedup and energy ef- ciency of 1.5-8.9 and 1.7-10.27 respectively. This dissertation also compares XSSD with previous work on intelligent storage and intelligent memory. The existing ecosystem and these new enabling technologies make this system more viable than earlier ones.« less

Development of a timing detector for the TOTEM experiment at the LHC

NASA Astrophysics Data System (ADS)

Minafra, Nicola

2017-09-01

The upgrade program of the TOTEM experiment will include the installation of timing detectors inside vertical Roman Pots to allow the reconstruction of the longitudinal vertex position in the presence of event pile-up in high- β^{\\ast} dedicated runs. The small available space inside the Roman Pot, optimized for high-intensity LHC runs, and the required time precision led to the study of a solution using single crystal CVD diamonds. The sensors are read out using fast low-noise front-end electronics developed by the TOTEM Collaboration, achieving a signal-to-noise ratio larger than 20 for MIPs. A prototype was designed, manufactured and tested during a test beam campaign, proving a time precision below 100ps and an efficiency above 99%. The geometry of the detector has been designed to guarantee uniform occupancy in the expected running conditions keeping, at the same time, the number of channels below 12. The read-out electronics was developed during an extensive campaign of beam tests dedicated first to the characterization of existing solution and then to the optimization of the electronics designed within the Collaboration. The detectors were designed to be read out using the SAMPIC chip, a fast sampler designed specifically for picosecond timing measurements with high-rate capabilities; later, a modified version was realized using the HPTDC to achieve the higher trigger rates required for the CT-PPS experiment. The first set of prototypes was successfully installed and tested in the LHC in November 2015; moreover the detectors modified for CT-PPS are successfully part of the global CMS data taking since October 2016.

Lifetime measurements in transitional nuclei by fast electronic scintillation timing

NASA Astrophysics Data System (ADS)

Caprio, M. A.; Zamfir, N. V.; Casten, R. F.; Amro, H.; Barton, C. J.; Beausang, C. W.; Cooper, J. R.; Gürdal, G.; Hecht, A. A.; Hutter, C.; Krücken, R.; McCutchan, E. A.; Meyer, D. A.; Novak, J. R.; Pietralla, N.; Ressler, J. J.; Berant, Z.; Brenner, D. S.; Gill, R. L.; Regan, P. H.

2002-10-01

A new generation of experiments studying nuclei in spherical-deformed transition regions has been motivated by the introduction of innovative theoretical approaches to the treatment of these nuclei. The important structural signatures in the transition regions, beyond the basic yrast level properties, involve γ-ray transitions between low-spin, non-yrast levels, and so information on γ-ray branching ratios and absolute matrix elements (or level lifetimes) for these transitions is crucial. A fast electronic scintillation timing (FEST) system [H. Mach, R. L. Gill, and M. Moszyński, Nucl. Instrum. Methods A 280, 49 (1989)], making use of BaF2 and plastic scintillation detectors, has been implemented at the Yale Moving Tape Collector for the measurement of lifetimes of states populated in β^ decay. Experiments in the A100 (Pd, Ru) and A150 (Dy, Yb) regions have been carried out, and a few examples will be presented. Supported by the US DOE under grants and contracts DE-FG02-91ER-40609, DE-FG02-88ER-40417, and DE-AC02-98CH10886 and by the German DFG under grant Pi 393/1.

Process-Structure-Property Relationships for 316L Stainless Steel Fabricated by Additive Manufacturing and Its Implication for Component Engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Nancy; Yee, J.; Zheng, B.

We investigate the process-structure-property relationships for 316L stainless steel prototyping utilizing 3-D laser engineered net shaping (LENS), a commercial direct energy deposition additive manufacturing process. Our study concluded that the resultant physical metallurgy of 3-D LENS 316L prototypes is dictated by the interactive metallurgical reactions, during instantaneous powder feeding/melting, molten metal flow and liquid metal solidification. This study also showed 3-D LENS manufacturing is capable of building high strength and ductile 316L prototypes due to its fine cellular spacing from fast solidification cooling, and the well-fused epitaxial interfaces at metal flow trails and interpass boundaries. However, without further LENS processmore » control and optimization, the deposits are vulnerable to localized hardness variation attributed to heterogeneous microstructure, i.e., the interpass heat-affected zone (HAZ) from repetitive thermal heating during successive layer depositions. Most significantly, the current deposits exhibit anisotropic tensile behavior, i.e., lower strain and/or premature interpass delamination parallel to build direction (axial). This anisotropic behavior is attributed to the presence of interpass HAZ, which coexists with flying feedstock inclusions and porosity from incomplete molten metal fusion. Our current observations and findings contribute to the scientific basis for future process control and optimization necessary for material property control and defect mitigation.« less

Rapid prototyping of microfluidic systems using a PDMS/polymer tape composite.

PubMed

Kim, Jungkyu; Surapaneni, Rajesh; Gale, Bruce K

2009-05-07

Rapid prototyping of microfluidic systems using a combination of double-sided tape and PDMS (polydimethylsiloxane) is introduced. PDMS is typically difficult to bond using adhesive tapes due to its hydrophobic nature and low surface energy. For this reason, PDMS is not compatible with the xurography method, which uses a knife plotter and various adhesive coated polymer tapes. To solve these problems, a PDMS/tape composite was developed and demonstrated in microfluidic applications. The PDMS/tape composite was created by spinning it to make a thin layer of PDMS over double-sided tape. Then the PDMS/tape composite was patterned to create channels using xurography, and bonded to a PDMS slab. After removing the backing paper from the tape, a complete microfluidic system could be created by placing the construct onto nearly any substrate; including glass, plastic or metal-coated glass/silicon substrates. The bond strength was shown to be sufficient for the pressures that occur in typical microfluidic channels used for chemical or biological analysis. This method was demonstrated in three applications: standard microfluidic channels and reactors, a microfluidic system with an integrated membrane, and an electrochemical biosensor. The PDMS/tape composite rapid prototyping technique provides a fast and cost effective fabrication method and can provide easy integration of microfluidic channels with sensors and other components without the need for a cleanroom facility.

The Virtual Watershed Observatory: Cyberinfrastructure for Model-Data Integration and Access

NASA Astrophysics Data System (ADS)

Duffy, C.; Leonard, L. N.; Giles, L.; Bhatt, G.; Yu, X.

2011-12-01

The Virtual Watershed Observatory (VWO) is a concept where scientists, water managers, educators and the general public can create a virtual observatory from integrated hydrologic model results, national databases and historical or real-time observations via web services. In this paper, we propose a prototype for automated and virtualized web services software using national data products for climate reanalysis, soils, geology, terrain and land cover. The VWO has the broad purpose of making accessible water resource simulations, real-time data assimilation, calibration and archival at the scale of HUC 12 watersheds (Hydrologic Unit Code) anywhere in the continental US. Our prototype for model-data integration focuses on creating tools for fast data storage from selected national databases, as well as the computational resources necessary for a dynamic, distributed watershed simulation. The paper will describe cyberinfrastructure tools and workflow that attempts to resolve the problem of model-data accessibility and scalability such that individuals, research teams, managers and educators can create a WVO in a desired context. Examples are given for the NSF-funded Shale Hills Critical Zone Observatory and the European Critical Zone Observatories within the SoilTrEC project. In the future implementation of WVO services will benefit from the development of a cloud cyber infrastructure as the prototype evolves to data and model intensive computation for continental scale water resource predictions.

Impact of pharmacy automation on patient waiting time: an application of computer simulation.

PubMed

Tan, Woan Shin; Chua, Siang Li; Yong, Keng Woh; Wu, Tuck Seng

2009-06-01

This paper aims to illustrate the use of computer simulation in evaluating the impact of a prototype automated dispensing system on waiting time in an outpatient pharmacy and its potential as a routine tool in pharmacy management. A discrete event simulation model was developed to investigate the impact of a prototype automated dispensing system on operational efficiency and service standards in an outpatient pharmacy. The simulation results suggest that automating the prescription-filing function using a prototype that picks and packs at 20 seconds per item will not assist the pharmacy in achieving the waiting time target of 30 minutes for all patients. Regardless of the state of automation, to meet the waiting time target, 2 additional pharmacists are needed to overcome the process bottleneck at the point of medication dispense. However, if the automated dispensing is the preferred option, the speed of the system needs to be twice as fast as the current configuration to facilitate the reduction of the 95th percentile patient waiting time to below 30 minutes. The faster processing speed will concomitantly allow the pharmacy to reduce the number of pharmacy technicians from 11 to 8. Simulation was found to be a useful and low cost method that allows an otherwise expensive and resource intensive evaluation of new work processes and technology to be completed within a short time.

High-order adaptive secondary mirrors: where are we?

NASA Astrophysics Data System (ADS)

Salinari, Piero; Sandler, David G.

1998-09-01

We discuss the current developments and the perspective performances of adaptive secondary mirrors for high order adaptive a correction on large ground based telescopes. The development of the basic techniques involved a large collaborative effort of public research Institutes and of private companies is now essentially complete. The next crucial step will be the construction of an adaptive secondary mirror for the 6.5 m MMT. Problems such as the fabrication of very thin mirrors, the low cost implementation of fast position sensors, of efficient and compact electromagnetic actuators, of the control and communication electronics, of the actuator control system, of the thermal control and of the mechanical layout can be considered as solved, in some cases with more than one viable solution. To verify performances at system level two complete prototypes have been built and tested, one at ThermoTrex and the other at Arcetri. The two prototypes adopt the same basic approach concerning actuators, sensor and support of the thin mirror, but differ in a number of aspects such as the material of the rigid back plate used as reference for the thin mirror, the number and surface density of the actuators, the solution adopted for the removal of the heat, and the design of the electronics. We discuss how the results obtained by of the two prototypes and by numerical simulations will guide the design of full size adaptive secondary units.

Simulation-based Testing of Control Software

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ozmen, Ozgur; Nutaro, James J.; Sanyal, Jibonananda

It is impossible to adequately test complex software by examining its operation in a physical prototype of the system monitored. Adequate test coverage can require millions of test cases, and the cost of equipment prototypes combined with the real-time constraints of testing with them makes it infeasible to sample more than a small number of these tests. Model based testing seeks to avoid this problem by allowing for large numbers of relatively inexpensive virtual prototypes that operate in simulation time at a speed limited only by the available computing resources. In this report, we describe how a computer system emulatormore » can be used as part of a model based testing environment; specifically, we show that a complete software stack including operating system and application software - can be deployed within a simulated environment, and that these simulations can proceed as fast as possible. To illustrate this approach to model based testing, we describe how it is being used to test several building control systems that act to coordinate air conditioning loads for the purpose of reducing peak demand. These tests involve the use of ADEVS (A Discrete Event System Simulator) and QEMU (Quick Emulator) to host the operational software within the simulation, and a building model developed with the MODELICA programming language using Buildings Library and packaged as an FMU (Functional Mock-up Unit) that serves as the virtual test environment.« less

Process-Structure-Property Relationships for 316L Stainless Steel Fabricated by Additive Manufacturing and Its Implication for Component Engineering

DOE PAGES

Yang, Nancy; Yee, J.; Zheng, B.; ...

2016-12-08

We investigate the process-structure-property relationships for 316L stainless steel prototyping utilizing 3-D laser engineered net shaping (LENS), a commercial direct energy deposition additive manufacturing process. Our study concluded that the resultant physical metallurgy of 3-D LENS 316L prototypes is dictated by the interactive metallurgical reactions, during instantaneous powder feeding/melting, molten metal flow and liquid metal solidification. This study also showed 3-D LENS manufacturing is capable of building high strength and ductile 316L prototypes due to its fine cellular spacing from fast solidification cooling, and the well-fused epitaxial interfaces at metal flow trails and interpass boundaries. However, without further LENS processmore » control and optimization, the deposits are vulnerable to localized hardness variation attributed to heterogeneous microstructure, i.e., the interpass heat-affected zone (HAZ) from repetitive thermal heating during successive layer depositions. Most significantly, the current deposits exhibit anisotropic tensile behavior, i.e., lower strain and/or premature interpass delamination parallel to build direction (axial). This anisotropic behavior is attributed to the presence of interpass HAZ, which coexists with flying feedstock inclusions and porosity from incomplete molten metal fusion. Our current observations and findings contribute to the scientific basis for future process control and optimization necessary for material property control and defect mitigation.« less

Development of a prototype chest digital tomosynthesis (CDT) R/F system with fast image reconstruction using graphics processing unit (GPU) programming

NASA Astrophysics Data System (ADS)

Choi, Sunghoon; Lee, Seungwan; Lee, Haenghwa; Lee, Donghoon; Choi, Seungyeon; Shin, Jungwook; Seo, Chang-Woo; Kim, Hee-Joung

2017-03-01

Digital tomosynthesis offers the advantage of low radiation doses compared to conventional computed tomography (CT) by utilizing small numbers of projections ( 80) acquired over a limited angular range. It produces 3D volumetric data, although there are artifacts due to incomplete sampling. Based upon these characteristics, we developed a prototype digital tomosynthesis R/F system for applications in chest imaging. Our prototype chest digital tomosynthesis (CDT) R/F system contains an X-ray tube with high power R/F pulse generator, flat-panel detector, R/F table, electromechanical radiographic subsystems including a precise motor controller, and a reconstruction server. For image reconstruction, users select between analytic and iterative reconstruction methods. Our reconstructed images of Catphan700 and LUNGMAN phantoms clearly and rapidly described the internal structures of phantoms using graphics processing unit (GPU) programming. Contrast-to-noise ratio (CNR) values of the CTP682 module of Catphan700 were higher in images using a simultaneous algebraic reconstruction technique (SART) than in those using filtered back-projection (FBP) for all materials by factors of 2.60, 3.78, 5.50, 2.30, 3.70, and 2.52 for air, lung foam, low density polyethylene (LDPE), Delrin® (acetal homopolymer resin), bone 50% (hydroxyapatite), and Teflon, respectively. Total elapsed times for producing 3D volume were 2.92 s and 86.29 s on average for FBP and SART (20 iterations), respectively. The times required for reconstruction were clinically feasible. Moreover, the total radiation dose from our system (5.68 mGy) was lower than that of conventional chest CT scan. Consequently, our prototype tomosynthesis R/F system represents an important advance in digital tomosynthesis applications.

Calibration and validation of a spar-type floating offshore wind turbine model using the FAST dynamic simulation tool

DOE PAGES

Browning, J. R.; Jonkman, J.; Robertson, A.; ...

2014-12-16

In this study, high-quality computer simulations are required when designing floating wind turbines because of the complex dynamic responses that are inherent with a high number of degrees of freedom and variable metocean conditions. In 2007, the FAST wind turbine simulation tool, developed and maintained by the U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL), was expanded to include capabilities that are suitable for modeling floating offshore wind turbines. In an effort to validate FAST and other offshore wind energy modeling tools, DOE funded the DeepCwind project that tested three prototype floating wind turbines at 1/50 th scalemore » in a wave basin, including a semisubmersible, a tension-leg platform, and a spar buoy. This paper describes the use of the results of the spar wave basin tests to calibrate and validate the FAST offshore floating simulation tool, and presents some initial results of simulated dynamic responses of the spar to several combinations of wind and sea states. Wave basin tests with the spar attached to a scale model of the NREL 5-megawatt reference wind turbine were performed at the Maritime Research Institute Netherlands under the DeepCwind project. This project included free-decay tests, tests with steady or turbulent wind and still water (both periodic and irregular waves with no wind), and combined wind/wave tests. The resulting data from the 1/50th model was scaled using Froude scaling to full size and used to calibrate and validate a full-size simulated model in FAST. Results of the model calibration and validation include successes, subtleties, and limitations of both wave basin testing and FAST modeling capabilities.« less

Marlene Dietrich in the German Classroom: A German Film Project--Humanities through the Golden Age of German Cinema.

ERIC Educational Resources Information Center

Flippo, Hyde

1993-01-01

Marlene Dietrich and other classic performers of German cinema can serve to open up a whole new realm for students of German, at secondary and postsecondary levels. By researching and viewing German and American film classics, students have opportunity to learn more about German language and an important element of German culture that has had…

Pharmacokinetics of a once-daily extended-release formulation of pramipexole in healthy male volunteers: three studies.

PubMed

Jenner, Peter; Könen-Bergmann, Michael; Schepers, Cornelia; Haertter, Sebastian

2009-11-01

Pramipexole is a dopamine agonist used in the treatment of Parkinson's disease. The currently available immediate-release (IR) formulation is taken orally 3 times daily. These studies were conducted to evaluate the pharmacokinetic properties of a variety of prototypes for a once-daily extended-release (ER) formulation of pramipexole and to further characterize the prototype whose pharmacokinetics best matched those of the IR formulation. Three Phase I studies were conducted, all in healthy adult men aged

Rigorous mathematical modelling for a Fast Corrector Power Supply in TPS

NASA Astrophysics Data System (ADS)

Liu, K.-B.; Liu, C.-Y.; Chien, Y.-C.; Wang, B.-S.; Wong, Y. S.

2017-04-01

To enhance the stability of beam orbit, a Fast Orbit Feedback System (FOFB) eliminating undesired disturbances was installed and tested in the 3rd generation synchrotron light source of Taiwan Photon Source (TPS) of National Synchrotron Radiation Research Center (NSRRC). The effectiveness of the FOFB greatly depends on the output performance of Fast Corrector Power Supply (FCPS); therefore, the design and implementation of an accurate FCPS is essential. A rigorous mathematical modelling is very useful to shorten design time and improve design performance of a FCPS. A rigorous mathematical modelling derived by the state-space averaging method for a FCPS in the FOFB of TPS composed of a full-bridge topology is therefore proposed in this paper. The MATLAB/SIMULINK software is used to construct the proposed mathematical modelling and to conduct the simulations of the FCPS. Simulations for the effects of the different resolutions of ADC on the output accuracy of the FCPS are investigated. A FCPS prototype is realized to demonstrate the effectiveness of the proposed rigorous mathematical modelling for the FCPS. Simulation and experimental results show that the proposed mathematical modelling is helpful for selecting the appropriate components to meet the accuracy requirements of a FCPS.

Fast segmentation of satellite images using SLIC, WebGL and Google Earth Engine

NASA Astrophysics Data System (ADS)

Donchyts, Gennadii; Baart, Fedor; Gorelick, Noel; Eisemann, Elmar; van de Giesen, Nick

2017-04-01

Google Earth Engine (GEE) is a parallel geospatial processing platform, which harmonizes access to petabytes of freely available satellite images. It provides a very rich API, allowing development of dedicated algorithms to extract useful geospatial information from these images. At the same time, modern GPUs provide thousands of computing cores, which are mostly not utilized in this context. In the last years, WebGL became a popular and well-supported API, allowing fast image processing directly in web browsers. In this work, we will evaluate the applicability of WebGL to enable fast segmentation of satellite images. A new implementation of a Simple Linear Iterative Clustering (SLIC) algorithm using GPU shaders will be presented. SLIC is a simple and efficient method to decompose an image in visually homogeneous regions. It adapts a k-means clustering approach to generate superpixels efficiently. While this approach will be hard to scale, due to a significant amount of data to be transferred to the client, it should significantly improve exploratory possibilities and simplify development of dedicated algorithms for geoscience applications. Our prototype implementation will be used to improve surface water detection of the reservoirs using multispectral satellite imagery.

A fast method for optical simulation of flood maps of light-sharing detector modules.

PubMed

Shi, Han; Du, Dong; Xu, JianFeng; Moses, William W; Peng, Qiyu

2015-12-01

Optical simulation of the detector module level is highly desired for Position Emission Tomography (PET) system design. Commonly used simulation toolkits such as GATE are not efficient in the optical simulation of detector modules with complicated light-sharing configurations, where a vast amount of photons need to be tracked. We present a fast approach based on a simplified specular reflectance model and a structured light-tracking algorithm to speed up the photon tracking in detector modules constructed with polished finish and specular reflector materials. We simulated conventional block detector designs with different slotted light guide patterns using the new approach and compared the outcomes with those from GATE simulations. While the two approaches generated comparable flood maps, the new approach was more than 200-600 times faster. The new approach has also been validated by constructing a prototype detector and comparing the simulated flood map with the experimental flood map. The experimental flood map has nearly uniformly distributed spots similar to those in the simulated flood map. In conclusion, the new approach provides a fast and reliable simulation tool for assisting in the development of light-sharing-based detector modules with a polished surface finish and using specular reflector materials.

Frontend electronics for high-precision single photo-electron timing using FPGA-TDCs

NASA Astrophysics Data System (ADS)

Cardinali, M.; Dzyhgadlo, R.; Gerhardt, A.; Götzen, K.; Hohler, R.; Kalicy, G.; Kumawat, H.; Lehmann, D.; Lewandowski, B.; Patsyuk, M.; Peters, K.; Schepers, G.; Schmitt, L.; Schwarz, C.; Schwiening, J.; Traxler, M.; Ugur, C.; Zühlsdorf, M.; Dodokhov, V. Kh.; Britting, A.; Eyrich, W.; Lehmann, A.; Uhlig, F.; Düren, M.; Föhl, K.; Hayrapetyan, A.; Kröck, B.; Merle, O.; Rieke, J.; Cowie, E.; Keri, T.; Montgomery, R.; Rosner, G.; Achenbach, P.; Corell, O.; Ferretti Bondy, M. I.; Hoek, M.; Lauth, W.; Rosner, C.; Sfienti, C.; Thiel, M.; Bühler, P.; Gruber, L.; Marton, J.; Suzuki, K.

2014-12-01

The next generation of high-luminosity experiments requires excellent particle identification detectors which calls for Imaging Cherenkov counters with fast electronics to cope with the expected hit rates. A Barrel DIRC will be used in the central region of the Target Spectrometer of the planned PANDA experiment at FAIR. A single photo-electron timing resolution of better than 100 ps is required by the Barrel DIRC to disentangle the complicated patterns created on the image plane. R&D studies have been performed to provide a design based on the TRB3 readout using FPGA-TDCs with a precision better than 20 ps RMS and custom frontend electronics with high-bandwidth pre-amplifiers and fast discriminators. The discriminators also provide time-over-threshold information thus enabling walk corrections to improve the timing resolution. Two types of frontend electronics cards optimised for reading out 64-channel PHOTONIS Planacon MCP-PMTs were tested: one based on the NINO ASIC and the other, called PADIWA, on FPGA discriminators. Promising results were obtained in a full characterisation using a fast laser setup and in a test experiment at MAMI, Mainz, with a small scale DIRC prototype.

Choosing Wisely in pediatric anesthesia: An interpretation from the German Scientific Working Group of Paediatric Anaesthesia (WAKKA).

PubMed

Becke, Karin; Eich, Christoph; Höhne, Claudia; Jöhr, Martin; Machotta, Andreas; Schreiber, Markus; Sümpelmann, Robert

2018-05-30

Inspired by the Choosing Wisely initiative, a group of pediatric anesthesiologists representing the German Working Group on Paediatric Anaesthesia (WAKKA) coined and agreed upon 10 concise positive ("dos") or negative ("don'ts") evidence-based recommendations. (i) In infants and children with robust indications for surgical, interventional, or diagnostic procedures, anesthesia or sedation should not be avoided or delayed due to the potential neurotoxicity associated with the exposure to anesthetics. (ii) In children without relevant preexisting illnesses (ie, ASA status I/II) who are scheduled for elective minor or medium-risk surgical procedures, no routine blood tests should be performed. (iii) Parental presence during the induction of anesthesia should be an option for children whenever possible. (iv) Perioperative fasting should be safe and child-friendly with shorter real fasting times and more liberal postoperative drinking and enteral feeding. (v) Perioperative fluid therapy should be safe and effective with physiologically composed balanced electrolyte solutions to maintain a normal extracellular fluid volume; addition of 1%-2.5% glucose to avoid lipolysis, hypoglycemia, and hyperglycemia, and colloids as needed to maintain a normal blood volume. (vi) To achieve safe and successful airway management, the locally accepted airway algorithm and continued teaching and training of basic and alternative techniques of ventilation and endotracheal intubation are required. (vii) Ultrasound and imaging systems (eg, transillumination) should be available for achieving central venous access and challenging peripheral venous and arterial access. (viii) Perioperative disturbances of the patient's homeostasis, such as hypotension, hypocapnia, hypothermia, hypoglycemia, hyponatremia, and severe anemia, should not be ignored and should be prevented or treated immediately. (ix) Pediatric patients with an elevated perioperative risk, eg, preterm and term neonates, infants, and critically ill children, should be treated at institutions where all caregivers have sufficient expertise and continuous clinical exposure to such patients. (x) A strategy for preventing postoperative vomiting, emergence delirium, and acute pain should be a part of every anesthetic procedure. © 2018 John Wiley & Sons Ltd.

When Learning Disturbs Memory – Temporal Profile of Retroactive Interference of Learning on Memory Formation

PubMed Central

Sosic-Vasic, Zrinka; Hille, Katrin; Kröner, Julia; Spitzer, Manfred; Kornmeier, Jürgen

2018-01-01

Introduction: Consolidation is defined as the time necessary for memory stabilization after learning. In the present study we focused on effects of interference during the first 12 consolidation minutes after learning. Participants had to learn a set of German – Japanese word pairs in an initial learning task and a different set of German – Japanese word pairs in a subsequent interference task. The interference task started in different experimental conditions at different time points (0, 3, 6, and 9 min) after the learning task and was followed by subsequent cued recall tests. In a control experiment the interference periods were replaced by rest periods without any interference. Results: The interference task decreased memory performance by up to 20%, with negative effects at all interference time points and large variability between participants concerning both the time point and the size of maximal interference. Further, fast learners seem to be more affected by interference than slow learners. Discussion: Our results indicate that the first 12 min after learning are highly important for memory consolidation, without a general pattern concerning the precise time point of maximal interference across individuals. This finding raises doubts about the generalized learning recipes and calls for individuality of learning schedules. PMID:29503621

… but You Are Not German." -- Afro-German Culture and Literature in the German Language Classroom

ERIC Educational Resources Information Center

Schenker, Theresa; Munro, Robert

2016-01-01

Units and classes dedicated to multiculturalism in Germany have predominantly focused on Turkish-German literature and culture. Afro-Germans have been a minority whose culture and literature have only marginally been included in German classes, even though Afro-Germans have been a part of Germany for centuries and have undergone efforts at…

Hydraulic Robotic Surgical Tool Changing Manipulator

PubMed Central

Pourghodrat, Abolfazl; Nelson, Carl A.; Oleynikov, Dmitry

2017-01-01

Natural orifice transluminal endoscopic surgery (NOTES) is a surgical technique to perform “scarless” abdominal operations. Robotic technology has been exploited to improve NOTES and circumvent its limitations. Lack of a multitasking platform is a major limitation. Manual tool exchange can be time consuming and may lead to complications such as bleeding. Previous multifunctional manipulator designs use electric motors. These designs are bulky, slow, and expensive. This paper presents design, prototyping, and testing of a hydraulic robotic tool changing manipulator. The manipulator is small, fast, low-cost, and capable of carrying four different types of laparoscopic instruments. PMID:28450979

SiFAP: a Simple Sub-Millisecond Astronomical Photometer

NASA Astrophysics Data System (ADS)

Ambrosino, F.; Meddi, F.; Nesci, R.; Rossi, C.; Sclavi, S.; Bruni, I.

2013-09-01

A new fast photometer based on SiPM technology was developed at the University of Rome "La Sapienza" starting from 2009. A first prototype was successfully tested observing the Crab pulsar at the Loiano telescope of the Bologna Observatory. In this paper we illustrate the improvements we applied to our instrument, concerning new cooled commercial sensors, a new version of our custom dedicated electronics and an upgraded control timing software. Finally we report the results obtained with this instrument on December 2012 on the Crab pulsar at the Loiano telescope to show its goodness and capabilities.

Creating a Team Archive During Fast-Paced Anomaly Response Activities in Space Missions

NASA Technical Reports Server (NTRS)

Malin, Jane T.; Hicks, LaDessa; Overland, David; Thronesbery, Carroll; Christofferesen, Klaus; Chow, Renee

2002-01-01

This paper describes a Web-based system to support the temporary Anomaly Response Team formed from distributed subteams in Space Shuttle and International Space Station missions. The system was designed for easy and flexible creation of small collections of files and links associated with work on a particular anomaly. The system supports privacy and levels of formality for the subteams. First we describe the supported groups and an anomaly response scenario. Then we describe the support system prototype, the Anomaly Response Tracking and Integration System (ARTIS). Finally, we describe our evaluation approach and the results of the evaluation.

Fast- or Slow-inactivated State Preference of Na+ Channel Inhibitors: A Simulation and Experimental Study

PubMed Central

Karoly, Robert; Lenkey, Nora; Juhasz, Andras O.; Vizi, E. Sylvester; Mike, Arpad

2010-01-01

Sodium channels are one of the most intensively studied drug targets. Sodium channel inhibitors (e.g., local anesthetics, anticonvulsants, antiarrhythmics and analgesics) exert their effect by stabilizing an inactivated conformation of the channels. Besides the fast-inactivated conformation, sodium channels have several distinct slow-inactivated conformational states. Stabilization of a slow-inactivated state has been proposed to be advantageous for certain therapeutic applications. Special voltage protocols are used to evoke slow inactivation of sodium channels. It is assumed that efficacy of a drug in these protocols indicates slow-inactivated state preference. We tested this assumption in simulations using four prototypical drug inhibitory mechanisms (fast or slow-inactivated state preference, with either fast or slow binding kinetics) and a kinetic model for sodium channels. Unexpectedly, we found that efficacy in these protocols (e.g., a shift of the “steady-state slow inactivation curve”), was not a reliable indicator of slow-inactivated state preference. Slowly associating fast-inactivated state-preferring drugs were indistinguishable from slow-inactivated state-preferring drugs. On the other hand, fast- and slow-inactivated state-preferring drugs tended to preferentially affect onset and recovery, respectively. The robustness of these observations was verified: i) by performing a Monte Carlo study on the effects of randomly modifying model parameters, ii) by testing the same drugs in a fundamentally different model and iii) by an analysis of the effect of systematically changing drug-specific parameters. In patch clamp electrophysiology experiments we tested five sodium channel inhibitor drugs on native sodium channels of cultured hippocampal neurons. For lidocaine, phenytoin and carbamazepine our data indicate a preference for the fast-inactivated state, while the results for fluoxetine and desipramine are inconclusive. We suggest that conclusions based on voltage protocols that are used to detect slow-inactivated state preference are unreliable and should be re-evaluated. PMID:20585544

78 FR 62307 - German-American Day, 2013

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-16

...-American Day, 2013 By the President of the United States of America A Proclamation Since the first German... opportunity on our shores. On German-American Day, we celebrate the vibrant threads of German heritage woven..., 2013, as German-American Day. I encourage all Americans to learn more about the history of German...

MIDAS, prototype Multivariate Interactive Digital Analysis System for large area earth resources surveys. Volume 1: System description

NASA Technical Reports Server (NTRS)

Christenson, D.; Gordon, M.; Kistler, R.; Kriegler, F.; Lampert, S.; Marshall, R.; Mclaughlin, R.

1977-01-01

A third-generation, fast, low cost, multispectral recognition system (MIDAS) able to keep pace with the large quantity and high rates of data acquisition from large regions with present and projected sensots is described. The program can process a complete ERTS frame in forty seconds and provide a color map of sixteen constituent categories in a few minutes. A principle objective of the MIDAS program is to provide a system well interfaced with the human operator and thus to obtain large overall reductions in turn-around time and significant gains in throughput. The hardware and software generated in the overall program is described. The system contains a midi-computer to control the various high speed processing elements in the data path, a preprocessor to condition data, and a classifier which implements an all digital prototype multivariate Gaussian maximum likelihood or a Bayesian decision algorithm. Sufficient software was developed to perform signature extraction, control the preprocessor, compute classifier coefficients, control the classifier operation, operate the color display and printer, and diagnose operation.

A systematic method of interconnection optimization for dense-array concentrator photovoltaic system.

PubMed

Siaw, Fei-Lu; Chong, Kok-Keong

2013-01-01

This paper presents a new systematic approach to analyze all possible array configurations in order to determine the most optimal dense-array configuration for concentrator photovoltaic (CPV) systems. The proposed method is fast, simple, reasonably accurate, and very useful as a preliminary study before constructing a dense-array CPV panel. Using measured flux distribution data, each CPV cells' voltage and current values at three critical points which are at short-circuit, open-circuit, and maximum power point are determined. From there, an algorithm groups the cells into basic modules. The next step is I-V curve prediction, to find the maximum output power of each array configuration. As a case study, twenty different I-V predictions are made for a prototype of nonimaging planar concentrator, and the array configuration that yields the highest output power is determined. The result is then verified by assembling and testing of an actual dense-array on the prototype. It was found that the I-V curve closely resembles simulated I-V prediction, and measured maximum output power varies by only 1.34%.

Development and Implementation of a New HELIOS Diagnostic using a Fast Piezoelectric Valve on the Prototype Material Plasma Exposure eXperiment

NASA Astrophysics Data System (ADS)

Ray, Holly; Biewer, Theodore; Caneses, Juan; Green, Jonathan; Lindquist, Elizabeth; McQuown, Levon; Schmitz, Oliver

2017-10-01

A new helium line-ratio spectral monitoring (HELIOS) diagnostic, using a piezoelectric valve with high duty cycles (on/off times ms), allowing for good background correction, and measured particle flowrates on the order of 1020 particles/second is being implemented on Oak Ridge National Laboratory's (ORNL) Prototype Material Plasma Exposure eXperiment (Proto-MPEX). Built in collaboration with the University of Wisconsin - Madison, the HELIOS diagnostic communicates with a Labview program for controlled bursts of helium into the vessel. The open magnetic geometry of Proto-MPEX is ideal for testing and characterizing a HELIOS diagnostic. The circular cross-section with four ports allows for cross comparison between different diagnostics: 1) Helium injection with the piezoelectric puff valve, 2) HELIOS line-of-sight high-gain observation, 3) scan-able Double Langmuir probe, and 4) HELIOS 2D imaging observation. Electron density and temperature measurements from the various techniques will be compared. This work was supported by the US. D.O.E. contract DE-AC05-00OR22725 and DE-SC00013911.

Universal electronics for miniature and automated chemical assays.

PubMed

Urban, Pawel L

2015-02-21

This minireview discusses universal electronic modules (generic programmable units) and their use by analytical chemists to construct inexpensive, miniature or automated devices. Recently, open-source platforms have gained considerable popularity among tech-savvy chemists because their implementation often does not require expert knowledge and investment of funds. Thus, chemistry students and researchers can easily start implementing them after a few hours of reading tutorials and trial-and-error. Single-board microcontrollers and micro-computers such as Arduino, Teensy, Raspberry Pi or BeagleBone enable collecting experimental data with high precision as well as efficient control of electric potentials and actuation of mechanical systems. They are readily programmed using high-level languages, such as C, C++, JavaScript or Python. They can also be coupled with mobile consumer electronics, including smartphones as well as teleinformatic networks. More demanding analytical tasks require fast signal processing. Field-programmable gate arrays enable efficient and inexpensive prototyping of high-performance analytical platforms, thus becoming increasingly popular among analytical chemists. This minireview discusses the advantages and drawbacks of universal electronic modules, considering their application in prototyping and manufacture of intelligent analytical instrumentation.

A One ppm NDIR Methane Gas Sensor with Single Frequency Filter Denoising Algorithm

PubMed Central

Zhu, Zipeng; Xu, Yuhui; Jiang, Binqing

2012-01-01

A non-dispersive infrared (NDIR) methane gas sensor prototype has achieved a minimum detection limit of 1 parts per million by volume (ppm). The central idea of the design of the sensor is to decrease the detection limit by increasing the signal to noise ratio (SNR) of the system. In order to decrease the noise level, a single frequency filter algorithm based on fast Fourier transform (FFT) is adopted for signal processing. Through simulation and experiment, it is found that the full width at half maximum (FWHM) of the filter narrows with the extension of sampling period and the increase of lamp modulation frequency, and at some optimum sampling period and modulation frequency, the filtered signal maintains a noise to signal ratio of below 1/10,000. The sensor prototype provides the key techniques for a hand-held methane detector that has a low cost and a high resolution. Such a detector may facilitate the detection of leakage of city natural gas pipelines buried underground, the monitoring of landfill gas, the monitoring of air quality and so on.

Innovative procedure for computer-assisted genioplasty: three-dimensional cephalometry, rapid-prototyping model and surgical splint.

PubMed

Olszewski, R; Tranduy, K; Reychler, H

2010-07-01

The authors present a new procedure of computer-assisted genioplasty. They determined the anterior, posterior and inferior limits of the chin in relation to the skull and face with the newly developed and validated three-dimensional cephalometric planar analysis (ACRO 3D). Virtual planning of the osteotomy lines was carried out with Mimics (Materialize) software. The authors built a three-dimensional rapid-prototyping multi-position model of the chin area from a medical low-dose CT scan. The transfer of virtual information to the operating room consisted of two elements. First, the titanium plates on the 3D RP model were pre-bent. Second, a surgical guide for the transfer of the osteotomy lines and the positions of the screws to the operating room was manufactured. The authors present the first case of the use of this model on a patient. The postoperative results are promising, and the technique is fast and easy-to-use. More patients are needed for a definitive clinical validation of this procedure. Copyright 2010 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

A portable eBook reader for the blind.

PubMed

Velazquez, Ramiro; Hernandez, Hermes; Preza, Enrique

2010-01-01

This paper presents the design and first prototype of the TactoBook system, a novel concept of reading assistive device that aims to make eBooks accessible to the blind. The TactoBook consists of a computer-based software translator that converts fast and automatically any eBook into Braille. The Braille version of the eBook is then encrypted as a file and stored in a USB memory drive which is later inserted and reproduced in a compact, lightweight, and highly-portable tactile terminal. Braille readers can store multiple eBooks in the same USB and access/reproduce them in the tactile terminal without this being plugged to a computer. The first Braille terminal developed is a 10-cell prototype based on a piezoelectric ultrasonic actuation approach. Its overall performance is quite similar to the one obtained with traditional Braille terminals. However, unlike them, the full device is only 1 kg mass and its compact dimensions (20 × 15 × 10 cm) make it easily carried by the user. A technical overview of all subsystems is presented and discussed.

A Systematic Method of Interconnection Optimization for Dense-Array Concentrator Photovoltaic System

PubMed Central

Siaw, Fei-Lu

2013-01-01

This paper presents a new systematic approach to analyze all possible array configurations in order to determine the most optimal dense-array configuration for concentrator photovoltaic (CPV) systems. The proposed method is fast, simple, reasonably accurate, and very useful as a preliminary study before constructing a dense-array CPV panel. Using measured flux distribution data, each CPV cells' voltage and current values at three critical points which are at short-circuit, open-circuit, and maximum power point are determined. From there, an algorithm groups the cells into basic modules. The next step is I-V curve prediction, to find the maximum output power of each array configuration. As a case study, twenty different I-V predictions are made for a prototype of nonimaging planar concentrator, and the array configuration that yields the highest output power is determined. The result is then verified by assembling and testing of an actual dense-array on the prototype. It was found that the I-V curve closely resembles simulated I-V prediction, and measured maximum output power varies by only 1.34%. PMID:24453823

Identify and Quantify the Mechanistic Sources of Sensor Performance Variation Between Individual Sensors SN1 and SN2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Diaz, Aaron A.; Baldwin, David L.; Cinson, Anthony D.

2014-08-06

This Technical Letter Report satisfies the M3AR-14PN2301022 milestone, and is focused on identifying and quantifying the mechanistic sources of sensor performance variation between individual 22-element, linear phased-array sensor prototypes, SN1 and SN2. This effort constitutes an iterative evolution that supports the longer term goal of producing and demonstrating a pre-manufacturing prototype ultrasonic probe that possesses the fundamental performance characteristics necessary to enable the development of a high-temperature sodium-cooled fast reactor inspection system. The scope of the work for this portion of the PNNL effort conducted in FY14 includes performing a comparative evaluation and assessment of the performance characteristics of themore » SN1 and SN2 22 element PA-UT probes manufactured at PNNL. Key transducer performance parameters, such as sound field dimensions, resolution capabilities, frequency response, and bandwidth are used as a metric for the comparative evaluation and assessment of the SN1 and SN2 engineering test units.« less

Additional information for “TREMOR: A Wireless, MEMS Accelerograph for Dense Arrays” (Evans et al., 2003)

USGS Publications Warehouse

Evans, John R.; Hamstra, Robert H.; Spudich, Paul; Kundig, Christoph; Camina, Patrick; Rogers, John A.

2003-01-01

The length of Evans et al. (2003) necessitated transfer of several less germane sections to this alternate forum to meet that venue’s needs. These sections include a description of the development of Figure 1, the plot of spatial variability so critical to the argument for dense arrays of strong-motion instruments; the description of the rapid, integer, computational method for PGV used in the TREMOR instrument (the Oakland instrument, the commercial prototype, and the commercial instrument); siting methods and strategies used for Class B TREMOR instruments and those that can be used for Class C instruments to preserve the cost advantages of such systems; and some general discussion of MEMS accelerometers, including a comparative Table with representative examples of Class A, B and C MEMS devices. (“MEMS” means “Micro-ElectroMechanical” Systems—“micromachined” sensors, generally of silicon. Classes A, B, and C are defined in Table 1.)

Policing Epistemic Deviance: Albert von Schrenck-Notzing and Albert Moll1

PubMed Central

Sommer, Andreas

2012-01-01

Shortly after the death of Albert von Schrenck-Notzing (1862–1929), the doyen of early twentieth century German para psychology, his former colleague in hypnotism and sexology Albert Moll (1862–1939) published a treatise on the psychology and pathology of parapsychologists, with Schrenck-Notzing serving as a prototype of a scientist suffering from an ‘occult complex’. Moll’s analysis concluded that parapsychologists vouching for the reality of supernormal phenomena, such as telepathy, clairvoyance, telekinesis and materialisations, suffered from a morbid will to believe, which paralysed their critical faculties and made them cover obvious mediumistic fraud. Using Moll’s treatment of Schrenck-Notzing as an historical case study of boundary disputes in science and medicine, this essay traces the career of Schrenck-Notzing as a researcher in hypnotism, sexology and parapsychology; discusses the relationship between Moll and Schrenck-Notzing; and problematises the pathologisation and defamation strategies of deviant epistemologies by authors such as Moll. PMID:23002296

FBIS report. Science and technology: Europe/International, March 29, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-03-29

;Partial Contents: Advanced Materials (EU Project to Improve Production in Metal Matrix Compounds Noted, Germany: Extremely Hard Carbon Coating Development, Italy: Director of CNR Metallic Materials Institute Interviewed); Aerospace (ESA Considers Delays, Reductions as Result of Budget Cuts, Italy: Space Agency`s Director on Restructuring, Future Plans); Automotive, Transportation (EU: Clean Diesel Engine Technology Research Reviewed); Biotechnology (Germany`s Problems, Successes in Biotechnology Discussed); Computers (EU Europort Parallel Computing Project Concluded, Italy: PQE 2000 Project on Massively Parallel Systems Viewed); Defense R&D (France: Future Tasks of `Brevel` Military Intelligence Drone Noted); Energy, Environment (German Scientist Tests Elimination of Phosphates); Advanced Manufacturing (France:more » Advanced Rapid Prototyping System Presented); Lasers, Sensors, Optics (France: Strategy of Cilas Laser Company Detailed); Microelectronics (France: Simulation Company to Develop Microelectronic Manufacturing Application); Nuclear R&D (France: Megajoule Laser Plan, Cooperation with Livermore Lab Noted); S&T Policy (EU Efforts to Aid Small Companies` Research Viewed); Telecommunications (France Telecom`s Way to Internet).« less

Low cost, high performance, self-aligning miniature optical systems

PubMed Central

Kester, Robert T.; Christenson, Todd; Kortum, Rebecca Richards; Tkaczyk, Tomasz S.

2009-01-01

The most expensive aspects in producing high quality miniature optical systems are the component costs and long assembly process. A new approach for fabricating these systems that reduces both aspects through the implementation of self-aligning LIGA (German acronym for lithographie, galvanoformung, abformung, or x-ray lithography, electroplating, and molding) optomechanics with high volume plastic injection molded and off-the-shelf glass optics is presented. This zero alignment strategy has been incorporated into a miniature high numerical aperture (NA = 1.0W) microscope objective for a fiber confocal reflectance microscope. Tight alignment tolerances of less than 10 μm are maintained for all components that reside inside of a small 9 gauge diameter hypodermic tubing. A prototype system has been tested using the slanted edge modulation transfer function technique and demonstrated to have a Strehl ratio of 0.71. This universal technology is now being developed for smaller, needle-sized imaging systems and other portable point-of-care diagnostic instruments. PMID:19543344

MoZis: mobile zoo information system: a case study for the city of Osnabrueck

NASA Astrophysics Data System (ADS)

Michel, Ulrich

2007-10-01

This paper describes a new project of the Institute for Geoinformatics and Remote Sensing, funded by the German Federal Foundation for the Environment (DBU, Deutsche Bundesstiftung Umwelt www.dbu.de). The goal of this project is to develop a mobile zoo information system for Pocket PCs and Smart phones. Visitors of the zoo will be able to use their own mobile devices or use Pocket PCs, which could be borrowed from the zoo to navigate around the zoo's facilities. The system will also provide additional multimedia based information such as audio-based material, animal video clips, and maps of their natural habitat. People could have access to the project at the zoo via wireless local area network or by downloading the necessary files using a home internet connection. Our software environment consists of proprietary and non-proprietary software solutions in order to make it as flexible as possible. Our first prototype was developed with Visual Studio 2003 and Visual Basic.Net.

Structuring Broadcast Audio for Information Access

NASA Astrophysics Data System (ADS)

Gauvain, Jean-Luc; Lamel, Lori

2003-12-01

One rapidly expanding application area for state-of-the-art speech recognition technology is the automatic processing of broadcast audiovisual data for information access. Since much of the linguistic information is found in the audio channel, speech recognition is a key enabling technology which, when combined with information retrieval techniques, can be used for searching large audiovisual document collections. Audio indexing must take into account the specificities of audio data such as needing to deal with the continuous data stream and an imperfect word transcription. Other important considerations are dealing with language specificities and facilitating language portability. At Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur (LIMSI), broadcast news transcription systems have been developed for seven languages: English, French, German, Mandarin, Portuguese, Spanish, and Arabic. The transcription systems have been integrated into prototype demonstrators for several application areas such as audio data mining, structuring audiovisual archives, selective dissemination of information, and topic tracking for media monitoring. As examples, this paper addresses the spoken document retrieval and topic tracking tasks.

[Comprehensive system integration and networking in operating rooms].

PubMed

Feußner, H; Ostler, D; Kohn, N; Vogel, T; Wilhelm, D; Koller, S; Kranzfelder, M

2016-12-01

A comprehensive surveillance and control system integrating all devices and functions is a precondition for realization of the operating room of the future. Multiple proprietary integrated operation room systems are currently available with a central user interface; however, they only cover a relatively small part of all functionalities. Internationally, there are at least three different initiatives to promote a comprehensive systems integration and networking in the operating room: the Japanese smart cyber operating theater (SCOT), the American medical device plug-and-play interoperability program (MDPnP) and the German secure and dynamic networking in operating room and hospital (OR.NET) project supported by the Federal Ministry of Education and Research. Within the framework of the internationally advanced OR.NET project, prototype solution approaches were realized, which make short-term and mid-term comprehensive data retrieval systems probable. An active and even autonomous control of the medical devices by the surveillance and control system (closed loop) is expected only in the long run due to strict regulatory barriers.

High brilliant thermal and cold moderator for the HBS neutron source project Jülich

NASA Astrophysics Data System (ADS)

Cronert, T.; Dabruck, J. P.; Doege, P. E.; Bessler, Y.; Klaus, M.; Hofmann, M.; Zakalek, P.; Rücker, U.; Lange, C.; Butzek, M.; Hansen, W.; Nabbi, R.; Brückel, T.

2016-09-01

The proposed High Brilliance Neutron Source (HBS), recognized within the Helmholtz Association of German Research Centres, will optimize the entire chain from particle source through particle accelerator, target, moderator, reflector, shielding, beam extraction, beam transport all the way to the detector, utilizing the nuclear Be(p,n) or Be(d,n) reaction in the lower MeV energy range. A D2O moderating reflector prototype (MRP) and a cold source were constructed and build according to MCNP parameter studies. The MRP was tested in a feasibility study at the TREFF instrument at MLZ (Garching). Cold beam extraction from the flux maximum within the moderator based on liquid para H2 and other cold moderators will be tested by energy spectroscopy via TOF-method. Different ratios of liquid ortho/para H2 will be fed to the cold moderator. The ratio will be controlled by feeding from reservoires of natural liquid H2 and a storage loop with an ortho/para converter and determined via online heat capacity measurement.

Testing and model-aided analysis of a 2 kW el PEMFC CHP-system

NASA Astrophysics Data System (ADS)

König, P.; Weber, A.; Lewald, N.; Aicher, T.; Jörissen, L.; Ivers-Tiffée, E.; Szolak, R.; Brendel, M.; Kaczerowski, J.

A prototype PEMFC CHP-system (combined heat and power) for decentralised energy supply in domestic applications has been installed in the Fuel Cell Testing Laboratory at the Institut für Werkstoffe der Elektrotechnik (IWE), Universität Karlsruhe (TH). The system, which was developed at the Zentrum für Sonnenenergie- und Wasserstoff-Forschung ZSW, Ulm (FC-stack) and the Fraunhofer-Institut für Solare Energiesysteme ISE, Freiburg (reformer) is operated and tested in close cooperation with the Stadtwerke Karlsruhe. The tests are carried out as part of the strategic project EDISon, which is supported by the German Federal Ministry of Economics and Technology (BMWA). The performance of the system is evaluated for different operating conditions. The tests include steady state measurements under different electrical and thermal loads as well as an analysis of the dynamic behaviour of the system during load changes. First results of these steady state and dynamic operation characteristics will be presented in this paper.

ExoMars Raman laser spectrometer for Exomars

NASA Astrophysics Data System (ADS)

Rull, F.; Sansano, A.; Díaz, E.; Canora, C. P.; Moral, A. G.; Tato, C.; Colombo, M.; Belenguer, T.; Fernández, M.; Manfredi, J. A. R.; Canchal, R.; Dávila, B.; Jiménez, A.; Gallego, P.; Ibarmia, S.; Prieto, J. A. R.; Santiago, A.; Pla, J.; Ramos, G.; Díaz, C.; González, C.

2011-10-01

The Raman Laser Spectrometer (RLS) is one of the Pasteur Payload instruments, within the ESA's Aurora Exploration Programme, ExoMars mission. ExoMars 2018 main Scientific objective is "Searching for evidence of past and present life on Mars". Raman Spectroscopy is used to analyze the vibrational modes of a substance either in the solid, liquid or gas state. It relies on the inelastic scattering (Raman Scattering) of monochromatic light produced by atoms and molecules. The radiation-matter interaction results in the energy of the exciting photons to be shifted up or down. The shift in energy appears as a spectral distribution and therefore provides an unique fingerprint by which the substances can be identified and structurally analyzed. The RLS is being developed by an European Consortium composed by Spanish, French, German and UK partners. It will perform Raman spectroscopy on crushed powdered samples inside the Rover's Analytical Laboratory Drawer. Instrument performances are being evaluated by means of simulation tools and development of an instrument prototype.

[Recurrent depressive disorder in Caspar David Friedrich. A pathographical approach with operationalized diagnosis].

PubMed

Spitzer, C; Dahlenburg, B; Freyberger, H J

2006-07-01

Caspar David Friedrich (1774 - 1840) is one of the most important German Romantic painters. In his paintings, he prototypically represents the melancholy, which has been mentioned by his contemporaries and later biographers. Art scientists have also referred to his melancholy for the interpretation of his work. From a medical point of view, there are only two pathographies which remain inconclusive. Having applied diagnostic criteria for psychiatric disorders to his letters and publications, to statements of his contemporaries and to his art, we propose that he had suffered from a recurrent major depression which occurred in 1799 for the first time. At least three depressive episodes followed before he was struck by a stroke in 1835. There are epidemiological, psychodynamic and personality-typological reasons supporting our diagnostic assumption. The course of his depression corresponds to phases of reduced creativity, to the chosen techniques and motives. Finally we discuss the implications of our approach for the pathographical method in general.

High-resolution, high-sensitivity, ground-based solar spectropolarimetry with a new fast imaging polarimeter. I. Prototype characterization

NASA Astrophysics Data System (ADS)

Iglesias, F. A.; Feller, A.; Nagaraju, K.; Solanki, S. K.

2016-05-01

Context. Remote sensing of weak and small-scale solar magnetic fields is of utmost relevance when attempting to respond to a number of important open questions in solar physics. This requires the acquisition of spectropolarimetric data with high spatial resolution (~10-1 arcsec) and low noise (10-3 to 10-5 of the continuum intensity). The main limitations to obtain these measurements from the ground, are the degradation of the image resolution produced by atmospheric seeing and the seeing-induced crosstalk (SIC). Aims: We introduce the prototype of the Fast Solar Polarimeter (FSP), a new ground-based, high-cadence polarimeter that tackles the above-mentioned limitations by producing data that are optimally suited for the application of post-facto image restoration, and by operating at a modulation frequency of 100 Hz to reduce SIC. Methods: We describe the instrument in depth, including the fast pnCCD camera employed, the achromatic modulator package, the main calibration steps, the effects of the modulation frequency on the levels of seeing-induced spurious signals, and the effect of the camera properties on the image restoration quality. Results: The pnCCD camera reaches 400 fps while keeping a high duty cycle (98.6%) and very low noise (4.94 e- rms). The modulator is optimized to have high (>80%) total polarimetric efficiency in the visible spectral range. This allows FSP to acquire 100 photon-noise-limited, full-Stokes measurements per second. We found that the seeing induced signals that are present in narrow-band, non-modulated, quiet-sun measurements are (a) lower than the noise (7 × 10-5) after integrating 7.66 min, (b) lower than the noise (2.3 × 10-4) after integrating 1.16 min and (c) slightly above the noise (4 × 10-3) after restoring case (b) by means of a multi-object multi-frame blind deconvolution. In addition, we demonstrate that by using only narrow-band images (with low S/N of 13.9) of an active region, we can obtain one complete set of high-quality restored measurements about every 2 s.

The development and testing of the fast imaging plasma spectrometer and its application in the plasma environment at Mercury

NASA Astrophysics Data System (ADS)

Koehn, Patrick Leo

The plasma environment at Mercury is a rich laboratory for studying the interaction of the solar wind with a planet. Three primary populations of ions exist at Mercury: solar wind, magnetospheric particles, and pickup ions. Pickup ions are generated through the ionization of Mercury's exosphere or are sputtered particles from the Mercury surface. A comprehensive mission to Mercury should include a sensor that is able to determine the dynamical properties and composition of all three plasma components. The Fast Imaging Plasma Spectrometer (FIPS) is an instrument to measure the composition of these ion populations and their three-dimensional velocity distribution functions. It is lightweight, fast, and has a very large field of view, and these properties made possible its accommodation within the highly mass- constrained payload of MESSENGER (MErcury: Surface, Space ENvironment, GEochemistry, Ranging) mission, a Mercury orbiter. This work details the development cycle of FIPS, from concept to prototype testing. It begins with science studies of the magnetospheric and pickup ion environments of Mercury, using state-of-the-art computer simulations to produce static and quasi-dynamic magnetospheric systems. Predictions are made of the spatially variable plasma environment at Mercury, and the temporally varying magnetosphere-solar wind interaction is examined. Pickup ion studies provide insights to particle loss mechanisms and the nature of the radar-bright regions at the Hermean poles. These studies produce science requirements for successfully measuring this environment with an orbiting mass spectrometer. With these science requirements in mind, a concept for a new electrostatic analyzer is created. This concept is considered from a theoretical standpoint, and compared with other, similarly performing instruments, both of the past and currently in use. The development cycle continues with instrument simulation, which allows the design to be adjusted to fit within the science requirements of the mission. Finally, a prototype electrostatic is constructed and tested in a space- simulating vacuum chamber system. The results of these tests are compared with the simulation results, and ultimately shown to fit within the science requirements for the MESSENGER mission.

Accent, Intelligibility, and the Role of the Listener: Perceptions of English-Accented German by Native German Speakers

ERIC Educational Resources Information Center

Hayes-Harb, Rachel; Watzinger-Tharp, Johanna

2012-01-01

We explore the relationship between accentedness and intelligibility, and investigate how listeners' beliefs about nonnative speech interact with their accentedness and intelligibility judgments. Native German speakers and native English learners of German produced German sentences, which were presented to 12 native German speakers in accentedness…

Analysis of relationships between German heavy horse breeds based on pedigree information.

PubMed

Aberle, Kerstin; Wrede, Jörn; Distl, Ottmar

2004-01-01

We analysed the relationship coefficients (R) between the four German heavy horse breeds South German Coldblood, Rhenish German Draught Horse, Schleswig Draught Horse and Black Forest Draught Horse. The relationship coefficient makes it possible to ascertain crossbreeding between the breeds over time, or autonomous developments of the breeds, respectively. The investigation revealed that the relationship coefficients between the German draught horse breeds were very low. The mean relationship coefficients between the four German heavy horse breeds were largest between the South German Coldblood and Schleswig Draught Horse (0.103%), whereas mean relationship coefficients were lowest between the Rhenish German and Black Forest Draught Horse (0.001%). The Rhenish German Draught Horse showed largest relationship coefficients with the Schleswig Draught Horse (0.09%), while the Black Forest Draught Horse was mostly related to the South German Coldblood (0.06%). The results reveal the presence of very few common progenitors of the breeds. The gene flow between the breeds is primarily due to crossbreeding of stallions and, especially, in the Rhenish German Draught Horse population breeding with a few mares from other German draught horse breeds.

Fast Timing for High-Rate Environments with Micromegas

NASA Astrophysics Data System (ADS)

Papaevangelou, Thomas; Desforge, Daniel; Ferrer-Ribas, Esther; Giomataris, Ioannis; Godinot, Cyprien; Diaz, Diego Gonzalez; Gustavsson, Thomas; Kebbiri, Mariam; Oliveri, Eraldo; Resnati, Filippo; Ropelewski, Leszek; Tsiledakis, Georgios; Veenhof, Rob; White, Sebastian

2018-02-01

The current state of the art in fast timing resolution for existing experiments is of the order of 100 ps on the time of arrival of both charged particles and electromagnetic showers. Current R&D on charged particle timing is approaching the level of 10 ps but is not primarily directed at sustained performance at high rates and under high radiation (as would be needed for HL-LHC pileup mitigation). We demonstrate aMicromegas based solution to reach this level of performance. The Micromegas acts as a photomultiplier coupled to a Cerenkovradiator front window, which produces sufficient UV photons to convert the ˜100 ps single-photoelectron jitter into a timing response of the order of 10-20 ps per incident charged particle. A prototype has been built in order to demonstrate this performance. The first laboratory tests with a pico-second laser have shown a time resolution of the order of 27 ps for ˜50 primary photoelectrons, using a bulk Micromegas readout.

Novel pulsed switched power supply for a fast field cycling NMR spectrometer.

PubMed

Sousa, D M; Fernandes, P A L; Marques, G D; Ribeiro, A C; Sebastião, P J

2004-01-01

In this paper, we outline the operating principles of a pulsed switched power supply for a fast field-cycling nuclear magnetic resonance spectrometer. The power supply uses a variant of a four-quadrant chopper with a duty cycle that defines the average output current. With this topology only two semiconductors are necessary to drive hundreds of amperes with an output power of several kilowatts. The output current ripple has a well-defined shape that can be reduced to acceptable values by a careful design of the semiconductors' controlling circuits and drivers. A power supply prototype was tested with a home build air-core magnet operating with fields between 0 and 0.21 T. The system is computer controlled using pulse generator and data acquisition PC cards, and specific user-friendly home-developed software. A comparative proton relaxometry study in two well-known liquid crystal compounds 5CB and MBBA was performed to check the reproducibility of the T1 measurements.

A “dry and wet hybrid” lithography technique for multilevel replication templates: Applications to microfluidic neuron culture and two-phase global mixing

PubMed Central

Paul, Debjani; Saias, Laure; Pedinotti, Jean-Cedric; Chabert, Max; Magnifico, Sebastien; Pallandre, Antoine; De Lambert, Bertrand; Houdayer, Claude; Brugg, Bernard; Peyrin, Jean-Michel; Viovy, Jean-Louis

2011-01-01

A broad range of microfluidic applications, ranging from cell culture to protein crystallization, requires multilevel devices with different heights and feature sizes (from micrometers to millimeters). While state-of-the-art direct-writing techniques have been developed for creating complex three-dimensional shapes, replication molding from a multilevel template is still the preferred method for fast prototyping of microfluidic devices in the laboratory. Here, we report on a “dry and wet hybrid” technique to fabricate multilevel replication molds by combining SU-8 lithography with a dry film resist (Ordyl). We show that the two lithography protocols are chemically compatible with each other. Finally, we demonstrate the hybrid technique in two different microfluidic applications: (1) a neuron culture device with compartmentalization of different elements of a neuron and (2) a two-phase (gas-liquid) global micromixer for fast mixing of a small amount of a viscous liquid into a larger volume of a less viscous liquid. PMID:21559239

Atmospheric correction of short-wave hyperspectral imagery using a fast, full-scattering 1DVar retrieval scheme

NASA Astrophysics Data System (ADS)

Thelen, J.-C.; Havemann, S.; Taylor, J. P.

2012-06-01

Here, we present a new prototype algorithm for the simultaneous retrieval of the atmospheric profiles (temperature, humidity, ozone and aerosol) and the surface reflectance from hyperspectral radiance measurements obtained from air/space-borne, hyperspectral imagers such as the 'Airborne Visible/Infrared Imager (AVIRIS) or Hyperion on board of the Earth Observatory 1. The new scheme, proposed here, consists of a fast radiative transfer code, based on empirical orthogonal functions (EOFs), in conjunction with a 1D-Var retrieval scheme. The inclusion of an 'exact' scattering code based on spherical harmonics, allows for an accurate treatment of Rayleigh scattering and scattering by aerosols, water droplets and ice-crystals, thus making it possible to also retrieve cloud and aerosol optical properties, although here we will concentrate on non-cloudy scenes. We successfully tested this new approach using two hyperspectral images taken by AVIRIS, a whiskbroom imaging spectrometer operated by the NASA Jet Propulsion Laboratory.

A poloidal section neutron camera for MAST upgrade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sangaroon, S.; Weiszflog, M.; Cecconello, M.

2014-08-21

The Mega Ampere Spherical Tokamak Upgrade (MAST Upgrade) is intended as a demonstration of the physics viability of the Spherical Tokamak (ST) concept and as a platform for contributing to ITER/DEMO physics. Concerning physics exploitation, MAST Upgrade plasma scenarios can contribute to the ITER Tokamak physics particularly in the field of fast particle behavior and current drive studies. At present, MAST is equipped with a prototype neutron camera (NC). On the basis of the experience and results from previous experimental campaigns using the NC, the conceptual design of a neutron camera upgrade (NC Upgrade) is being developed. As part ofmore » the MAST Upgrade, the NC Upgrade is considered a high priority diagnostic since it would allow studies in the field of fast ions and current drive with good temporal and spatial resolution. In this paper, we explore an optional design with the camera array viewing the poloidal section of the plasma from different directions.« less

Fast, High-Resolution Terahertz Radar Imaging at 25 Meters

NASA Technical Reports Server (NTRS)

Cooper, Ken B.; Dengler, Robert J.; Llombart, Nuria; Talukder, Ashit; Panangadan, Anand V.; Peay, Chris S.; Siegel, Peter H.

2010-01-01

We report improvements in the scanning speed and standoff range of an ultra-wide bandwidth terahertz (THz) imaging radar for person-borne concealed object detection. Fast beam scanning of the single-transceiver radar is accomplished by rapidly deflecting a flat, light-weight subreflector in a confocal Gregorian optical geometry. With RF back-end improvements also implemented, the radar imaging rate has increased by a factor of about 30 compared to that achieved previously in a 4 m standoff prototype instrument. In addition, a new 100 cm diameter ellipsoidal aluminum reflector yields beam spot diameters of approximately 1 cm over a 50x50 cm field of view at a range of 25 m, although some aberrations are observed that probably arise from misaligned optics. Through-clothes images of a concealed threat at 25 m range, acquired in 5 seconds, are presented, and the impact of reduced signal-to-noise from an even faster frame rate is analyzed. These results inform the system requirements for eventually achieving sub-second or video-rate THz radar imaging.

Early melanoma diagnosis with mobile imaging.

PubMed

Do, Thanh-Toan; Zhou, Yiren; Zheng, Haitian; Cheung, Ngai-Man; Koh, Dawn

2014-01-01

We research a mobile imaging system for early diagnosis of melanoma. Different from previous work, we focus on smartphone-captured images, and propose a detection system that runs entirely on the smartphone. Smartphone-captured images taken under loosely-controlled conditions introduce new challenges for melanoma detection, while processing performed on the smartphone is subject to computation and memory constraints. To address these challenges, we propose to localize the skin lesion by combining fast skin detection and fusion of two fast segmentation results. We propose new features to capture color variation and border irregularity which are useful for smartphone-captured images. We also propose a new feature selection criterion to select a small set of good features used in the final lightweight system. Our evaluation confirms the effectiveness of proposed algorithms and features. In addition, we present our system prototype which computes selected visual features from a user-captured skin lesion image, and analyzes them to estimate the likelihood of malignance, all on an off-the-shelf smartphone.

Experimental study on the damping of FAST cabin suspension system

NASA Astrophysics Data System (ADS)

Li, Hui; Sun, Jing-hai; Zhang, Xin-yu; Zhu, Wen-bai; Pan, Gao-feng; Yang, Qing-ge

2012-09-01

The focus cabin suspension of the FAST telescope has structurally weak-stiffness dynamics with low damping performance, which makes it quite sensitive to wind-induced vibrations. A reasonable estimation about the damping is very important for the control performance evaluation of the prototype. It is a quite difficult task as the telescope is no at available yet. In the paper, a preliminary analysis is first made on the aerodynamic damping. Then a series of experimental models are tested for measuring the total damping. The scales of these models range from 10m to 50m in diameter while 6 test parameters are specially designed to check the damping sensitivity. The Ibrahim time domain (ITD) method is employed to identify the damping from the measured cabin response. The identification results indicate that the lowest damping ratio of the models is about 0.2%~0.4%. Friction-type cabin-cable joint seems to have main influence on the system damping.

Hall-Effect Based Semi-Fast AC On-Board Charging Equipment for Electric Vehicles

PubMed Central

Milanés-Montero, María Isabel; Gallardo-Lozano, Javier; Romero-Cadaval, Enrique; González-Romera, Eva

2011-01-01

The expected increase in the penetration of electric vehicles (EV) and plug-in hybrid electric vehicles (PHEV) will produce unbalanced conditions, reactive power consumption and current harmonics drawn by the battery charging equipment, causing a great impact on the power quality of the future smart grid. A single-phase semi-fast electric vehicle battery charger is proposed in this paper. This ac on-board charging equipment can operate in grid-to-vehicle (G2V) mode, and also in vehicle-to-grid (V2G) mode, transferring the battery energy to the grid when the vehicle is parked. The charger is controlled with a Perfect Harmonic Cancellation (PHC) strategy, contributing to improve the grid power quality, since the current demanded or injected has no harmonic content and a high power factor. Hall-effect current and voltage transducers have been used in the sensor stage to carry out this control strategy. Experimental results with a laboratory prototype are presented. PMID:22163697

Fabrication and electro-optic characteristics of polymer-stabilized V-mode FLCD and intrinsic H-V-mode FLCD: their application to AM LCDs

NASA Astrophysics Data System (ADS)

Kobayashi, Shunsuke; Furuta, Hirokazu; Murakami, Yuji; Xu, Jun; Mochizuki, Akihiro

2003-04-01

Defect free polymer-stabilized (PS-)V-mode FLCDs and intrinsic half (H-)V-mode FLCDs have been fabricated; they exhibit high contrast ratio over 700:1 and high reliability for a temperature cycling test by using specially developed polyimide alignment materials, RN-1411 series, from Nissan Chem. Ind., and also by adopting special alignment technique such as appropriate rubbing technique, photoalignment, and ion beam irradiation techniques and also particularly developed polymer-stabilization technique. These FLCDs are shown to be useful for implementing a field sequential type full color (FS-FC) LCDs due to their fast response with the response time of τ = 100μs ~ 500μs that is 10 to 100 times faster that those of LCDs using NLCs. We have developed several prototype models of FS-FC LCDs having VGA specifications that exhibit good performance for displaying fast moving video rate images with wide color gamut.

Hall-effect based semi-fast AC on-board charging equipment for electric vehicles.

PubMed

Milanés-Montero, María Isabel; Gallardo-Lozano, Javier; Romero-Cadaval, Enrique; González-Romera, Eva

2011-01-01

The expected increase in the penetration of electric vehicles (EV) and plug-in hybrid electric vehicles (PHEV) will produce unbalanced conditions, reactive power consumption and current harmonics drawn by the battery charging equipment, causing a great impact on the power quality of the future smart grid. A single-phase semi-fast electric vehicle battery charger is proposed in this paper. This ac on-board charging equipment can operate in grid-to-vehicle (G2V) mode, and also in vehicle-to-grid (V2G) mode, transferring the battery energy to the grid when the vehicle is parked. The charger is controlled with a Perfect Harmonic Cancellation (PHC) strategy, contributing to improve the grid power quality, since the current demanded or injected has no harmonic content and a high power factor. Hall-effect current and voltage transducers have been used in the sensor stage to carry out this control strategy. Experimental results with a laboratory prototype are presented.

Design of a high-speed electrochemical scanning tunneling microscope.

PubMed

Yanson, Y I; Schenkel, F; Rost, M J

2013-02-01

In this paper, we present a bottom-up approach to designing and constructing a high-speed electrochemical scanning tunneling microscope (EC-STM). Using finite element analysis (FEA) calculations of the frequency response of the whole mechanical loop of the STM, we analyzed several geometries to find the most stable one that could facilitate fast scanning. To test the FEA results, we conducted measurements of the vibration amplitudes using a prototype STM setup. Based on the FEA analysis and the measurement results, we identified the potentially most disturbing vibration modes that could impair fast scanning. By modifying the design of some parts of the EC-STM, we reduced the amplitudes as well as increased the resonance frequencies of these modes. Additionally, we designed and constructed an electrochemical flow-cell that allows STM imaging in a flowing electrolyte, and built a bi-potentiostat to achieve electrochemical potential control during the measurements. Finally, we present STM images acquired during high-speed imaging in air as well as in an electrochemical environment using our newly-developed EC-STM.

Fast Resistive Bolometry

NASA Astrophysics Data System (ADS)

Graham, Jeffrey

2005-10-01

A bolometer with microsecond scale response time is under construction for the Caltech spheromak experiment to measure radiation from a ˜20 μs duration plasma discharge emitting ˜10^2---10^3 kW/m^2. A gold film several micrometers thick absorbs the radiation, heats up, and the consequent change in resistance can be measured. The film itself is vacuum deposited upon a glass slide. Several geometries for the film are under consideration to optimize the amount of radiation absorbed, the response time and the signal-to-noise ratio. We measure the change in voltage across the film for a known current driven through it; a square pulse (3---30A, ˜20 μs) is used to avoid Joule heating. Results from prototypes tested with a UV flashlamp will be presented. After optimizing the bolometer design, the final vacuum-compatible diagnostic would consist of a plasma-facing bolometer and a reference in a camera obscura. This device could provide a design for fast resistive bolometry.

Olfactory CNG channel desensitization by Ca2+/CaM via the B1b subunit affects response termination but not sensitivity to recurring stimulation.

PubMed

Song, Yijun; Cygnar, Katherine D; Sagdullaev, Botir; Valley, Matthew; Hirsh, Sarah; Stephan, Aaron; Reisert, Johannes; Zhao, Haiqing

2008-05-08

Ca2+/calmodulin-mediated negative feedback is a prototypical regulatory mechanism for Ca2+-permeable ion channels. In olfactory sensory neurons (OSNs), such regulation on the cyclic nucleotide-gated (CNG) channel is considered a major mechanism of OSN adaptation. To determine the role of Ca2+/calmodulin desensitization of the olfactory CNG channel, we introduced a mutation in the channel subunit CNGB1b in mice that rendered the channel resistant to fast desensitization by Ca2+/calmodulin. Contrary to expectations, mutant OSNs showed normal receptor current adaptation to repeated stimulation. Rather, they displayed slower response termination and, consequently, reduced ability to transmit olfactory information to the olfactory bulb. They also displayed reduced response decline during sustained odorant exposure. These results suggest that Ca2+/calmodulin-mediated CNG channel fast desensitization is less important in regulating the sensitivity to recurring stimulation than previously thought and instead functions primarily to terminate OSN responses.

Atom-chip-based quantum gravimetry for the precise determination of absolute gravity

NASA Astrophysics Data System (ADS)

Abend, Sven; Schubert, Christian; Ertmer, Wolfgang; Rasel, Ernst

2017-04-01

We present a novel technique for the precise measurement of absolute local gravity with a quantum gravimeter based on an atom chip. Atom interferometry utilizes the interference of matter waves interrogated by laser light to read out inertial forces. Today's generation of these devices typically operate with test mass samples, that consists of ensembles of laser cooled atoms. Their performance is limited by the velocity spread and finite-size of the test masses that impose systematic uncertainties at the level of a few μGal [1]. Rather than laser cooled atoms we employ quantum degenerate ensembles, so called Bose-Einstein condensates [2], as ultra-sensitive probes for gravity. These sources offer unique properties that will allow to overcome the current limitations in the next generation of sensors. Furthermore, atom-chip technology offers the possibility to generate Bose-Einstein condensates in a fast and reliable way. We present a lab-based prototype that uses the atom chip itself to retro-reflect the interrogation laser and thus serves as inertial reference inside the vacuum [3]. With this setup, it is possible to demonstrate all necessary steps to measure gravity, including the preparation of the source, spanning an interferometer as well as the detection of the output signal. All steps are pursued on a baseline of 1 cm right below the atom chip and to analyze relevant systematic effects. In the framework of the center of excellence geoQ a next generation device is under construction at the Institut für Quantenoptik, that will target for in-field measurements. This device will feature a state-of-the-art atom-chip source with a high-flux of ultra-cold atoms at a repetition rate of 1-2 Hz [4]. The device will be characterized in cooperation with the Müller group at the Institut für Erdmessung the sensor and finally employed in a campaign to measure the Fennoscandian uplift at the level of 1 μGal. The presented work is supported by the CRC 1227 DQ-mat, the CRC 1128 geo-Q, the RTG 1729, the QUEST-LFS, by the German Space Agency (DLR) with funds provided by the Federal Ministry of Economic Affairs and Energy (BMWi) due to an enactment of the German Bundestag under Grant No. DLR 50WM1552-1557. [1] A. Peters et al., Nature 400, 849, 1999; A. Louchet-Chauvet et al., New J. Phys. 13, 065026, 2011; C. Freier et al., J. of Phys.: Conf. Series 723, 012050, 2016; V. Schkolnik et al., Appl. Phys. B 120, 311-316 (2015). [2] K. B. Davis et al., Phys. Rev. Lett. 74, 5202, 1995; M. H. Anderson et al., Science 269, 198, 1995; C. C. Bradley et al., Phys. Rev. Lett. 75, 1687, 1995. [3] S. Abend et al., Phys. Rev. Lett. 117, 203003, 2016. [4] J. Rudolph et al., New J. Phys. 17, 065001, 2015.

Innovative power conversion system for the French SFR prototype, ASTRID

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cachon, L.; Biscarrat, C.; Morin, F.

2012-07-01

In the framework of the French Act of 28 June 2006 about nuclear materials and waste management, the prototype ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration), foreseen in operation by the 20's, will have to demonstrate not only the minor actinide transmutation capability, but also the progress made in Sodium Fast Reactor (SFR) technology on an industrial scale, by qualifying innovative options. Some of these options still require improvements, especially in the field of operability and safety. In fact, one of the main issues with the standard steam/water Power Conversion System (PCS) of SFR is the fast and energeticmore » chemical reaction between water and sodium, which could occur in steam generators in case of tube failure. To manage the sodium/water reaction, one way consists in minimizing the impact of such event: hence studies are carried out on steam generator design, improvement of the physical knowledge of this phenomenon, development of numerical simulation to predict the reaction onset and consequences, and associated detection improvement. On the other hand, the other way consists in eliminating sodium/water reaction. In this frame, the CEA contribution to the feasibility evaluation of an alternative innovative PCS (replacing steam/water by 180 bar pressurised nitrogen) is focused on the following main topics: - The parametric study leading to nitrogen selection: the thermodynamic cycle efficiency optimisation on Brayton cycles is performed with several gases at different pressures. - The design of innovative compact heat exchangers for the gas loop: here the key points are the nuclear codification associated with inspection capability, the innovative welding process and the thermal-hydraulic and thermal-mechanic optimisations. After a general introduction of the ASTRID project, this paper presents in detail these different feasibility studies being led on the innovative gas PCS for an SFR. (authors)« less

(abstract) Student Involvement in the Pluto Mission

NASA Technical Reports Server (NTRS)

Weinstein, Stacy

1994-01-01

The Pluto Fast Flyby mission development baseline consists of 2 identical spacecraft (120 - 165 kg) to be launched to Pluto/ Charon in the late 1990s. These spacecraft are intended to fly by Pluto and Charon in order to perform various remote-sensing scientific investigations and have a mission development cost less than $400M (FY92$) through launch plus 30 days. The Pluto team is committed to involving students in all areas of mission development and operations. In November 1992, the Pluto team sent a request for information to industry and universities looking for ways to lower the mass and cost of the mission. A number of universities responded with creative and promising technological developments. In addition to contracts with industry and other federal labs, contracts were signed with schools which allowed students to apply their research, enabling the Pluto team to use valuable resources on a variety of advanced technology endeavors. Perhaps the most exciting aspect of these investigations was that the deliverables that the students produced were not just final reports, but actual prototype hardware complete with write-ups on lessons learned in machining, programming, and design. Another exciting development was a prototype adapter competition in which 7 universities competed to design, build, and test their idea of a lightweight spacecraft-propulsion stack adapter. Georgia Tech won with an innovative dodecahedron composite lattice cone. Other students from other universities were involved as well. All in all, over 40 students from 20 different colleges made significant contributions to the Pluto Fast Flyby mission development through their efforts. This paper will give an overview of Pluto student involvement, the technologies which they examined, and useful results for the mission.

Possible Circuit Architectures for Molecular Nanoelectronics

NASA Astrophysics Data System (ADS)

Likharev, Konstantin

2003-03-01

Chemically-directed self-assembly of molecular devices is apparently the only feasible way to continue the fast progress of microelectronics after its Moore-Laws-based development runs into the wall of physical and economic limitations [1]. The architectures of VLSI circuits using such devices should be substantially fault-tolerant and accommodate other their features including low transconductance. The most significant feature of all promising suggested architectures is the hybridization of three technologies: advanced CMOS, simple nanowire arrays, and molecular devices self-assembling on these wires. Molecular memory arrays may have a simple structure, and their simple prototypes have already been implemented experimentally [2]. In contrast, the logic circuit development is just starting. I will describe a family of neuromorphic networks based on so-called CrossNet arrays [3] that look promising for advanced information processing, starting from fast image recognition and beyond. This architecture may combine very high density (above 10^12 functions per cm^2) and relatively high speed (100-ns-scale latency of cell-to-cell communications) at acceptable power consumption. In future, these features may allow to put an artificial analog of the human cerebral cortex, capable of processing information and (hopefully) self-evolution at 4 to 5 orders of magnitude faster than its biological prototype, on a 20x20 cm^2 silicon wafer. [1] K. Likharev, "Electronics Below 20-nm", see http://rsfq1.physics.sunysb.edu/ likharev/nano/ForMorkoc.pdf. [2] See, e.g, http://nanotechweb.org/articles/news/1/9/8/1. [3] O. Turel and K. Likharev, Int. J. of Circuit Theory and Applications 31, No.1 (2003); see http://rsfq1.physics.sunysb.edu/ likharev/nano/Preprint070102.pdf.

Fast Fourier Transform Co-Processor (FFTC)- Towards Embedded GFLOPs

NASA Astrophysics Data System (ADS)

Kuehl, Christopher; Liebstueckel, Uwe; Tejerina, Isaac; Uemminghaus, Michael; Wite, Felix; Kolb, Michael; Suess, Martin; Weigand, Roland

2012-08-01

Many signal processing applications and algorithms perform their operations on the data in the transform domain to gain efficiency. The Fourier Transform Co- Processor has been developed with the aim to offload General Purpose Processors from performing these transformations and therefore to boast the overall performance of a processing module. The IP of the commercial PowerFFT processor has been selected and adapted to meet the constraints of the space environment.In frame of the ESA activity “Fast Fourier Transform DSP Co-processor (FFTC)” (ESTEC/Contract No. 15314/07/NL/LvH/ma) the objectives were the following:Production of prototypes of a space qualified version of the commercial PowerFFT chip called FFTC based on the PowerFFT IP.The development of a stand-alone FFTC Accelerator Board (FTAB) based on the FFTC including the Controller FPGA and SpaceWire Interfaces to verify the FFTC function and performance.The FFTC chip performs its calculations with floating point precision. Stand alone it is capable computing FFTs of up to 1K complex samples in length in only 10μsec. This corresponds to an equivalent processing performance of 4.7 GFlops. In this mode the maximum sustained data throughput reaches 6.4Gbit/s. When connected to up to 4 EDAC protected SDRAM memory banks the FFTC can perform long FFTs with up to 1M complex samples in length or multidimensional FFT- based processing tasks.A Controller FPGA on the FTAB takes care of the SDRAM addressing. The instructions commanded via the Controller FPGA are used to set up the data flow and generate the memory addresses.The presentation will give and overview on the project, including the results of the validation of the FFTC ASIC prototypes.

Fast Fourier Transform Co-processor (FFTC), towards embedded GFLOPs

NASA Astrophysics Data System (ADS)

Kuehl, Christopher; Liebstueckel, Uwe; Tejerina, Isaac; Uemminghaus, Michael; Witte, Felix; Kolb, Michael; Suess, Martin; Weigand, Roland; Kopp, Nicholas

2012-10-01

Many signal processing applications and algorithms perform their operations on the data in the transform domain to gain efficiency. The Fourier Transform Co-Processor has been developed with the aim to offload General Purpose Processors from performing these transformations and therefore to boast the overall performance of a processing module. The IP of the commercial PowerFFT processor has been selected and adapted to meet the constraints of the space environment. In frame of the ESA activity "Fast Fourier Transform DSP Co-processor (FFTC)" (ESTEC/Contract No. 15314/07/NL/LvH/ma) the objectives were the following: • Production of prototypes of a space qualified version of the commercial PowerFFT chip called FFTC based on the PowerFFT IP. • The development of a stand-alone FFTC Accelerator Board (FTAB) based on the FFTC including the Controller FPGA and SpaceWire Interfaces to verify the FFTC function and performance. The FFTC chip performs its calculations with floating point precision. Stand alone it is capable computing FFTs of up to 1K complex samples in length in only 10μsec. This corresponds to an equivalent processing performance of 4.7 GFlops. In this mode the maximum sustained data throughput reaches 6.4Gbit/s. When connected to up to 4 EDAC protected SDRAM memory banks the FFTC can perform long FFTs with up to 1M complex samples in length or multidimensional FFT-based processing tasks. A Controller FPGA on the FTAB takes care of the SDRAM addressing. The instructions commanded via the Controller FPGA are used to set up the data flow and generate the memory addresses. The paper will give an overview on the project, including the results of the validation of the FFTC ASIC prototypes.

Conception of a New Recoil Proton Telescope for Real-Time Neutron Spectrometry in Proton-Therapy

NASA Astrophysics Data System (ADS)

Combe, Rodolphe; Arbor, Nicolas; el Bitar, Ziad; Higueret, Stéphane; Husson, Daniel

2018-01-01

Neutrons are the main type of secondary particles emitted in proton-therapy. Because of the risk of secondary cancer and other late occurring effects, the neutron dose should be included in the out-of-field dose calculations. A neutron spectrometer has to be used to take into account the energy dependence of the neutron radiological weighting factor. Due to its high dependence on various parameters of the irradiation (beam, accelerator, patient), the neutron spectrum should be measured independently for each treatment. The current reference method for the measurement of the neutron energy, the Bonner Sphere System, consists of several homogeneous polyethylene spheres with increasing diameters equipped with a proportional counter. It provides a highresolution reconstruction of the neutron spectrum but requires a time-consuming work of signal deconvolution. New neutron spectrometers are being developed, but the main experimental limitation remains the high neutron flux in proton therapy treatment rooms. A new model of a real-time neutron spectrometer, based on a Recoil Proton Telescope technology, has been developed at the IPHC. It enables a real-time high-rate reconstruction of the neutron spectrum from the measurement of the recoil proton trajectory and energy. A new fast-readout microelectronic integrated sensor, called FastPixN, has been developed for this specific purpose. A first prototype, able to detect neutrons between 5 and 20 MeV, has already been validated for metrology with the AMANDE facility at Cadarache. The geometry of the new Recoil Proton Telescope has been optimized via extensive Geant4 Monte Carlo simulations. Uncertainty sources have been carefully studied in order to improve simultaneously efficiency and energy resolution, and solutions have been found to suppress the various expected backgrounds. We are currently upgrading the prototype for secondary neutron detection in proton therapy applications.

Prototype Control System for Compensation of Superconducting Cavities Detuning Using Piezoelectric Actuators

NASA Astrophysics Data System (ADS)

Przygoda, K.; Piotrowski, A.; Jablonski, G.; Makowski, D.; Pozniak, T.; Napieralski, A.

2009-08-01

Pulsed operation of high gradient superconducting radio frequency (SCRF) cavities results in dynamic Lorentz force detuning (LFD) approaching or exceeding the bandwidth of the cavity of order of a few hundreds of Hz. The resulting modulation of the resonance frequency of the cavity is leading to a perturbation of the amplitude and phase of the accelerating field, which can be controlled only at the expense of RF power. Presently, at various labs, a piezoelectric fast tuner based on an active compensation scheme for the resonance frequency control of the cavity is under study. The tests already performed in the Free Electron Laser in Hamburg (FLASH), proved the possibility of Lorentz force detuning compensation by the means of the piezo element excited with the single period of sine wave prior to the RF pulse. The X-Ray Free Electron Laser (X-FEL) accelerator, which is now under development in Deutsche Elektronen-Synchrotron (DESY), will consists of around 800 cavities with a fast tuner fixture including the actuator/sensor configuration. Therefore, it is necessary to design a distributed control system which would be able to supervise around 25 RF stations, each one comprised of 32 cavities. The Advanced Telecomunications Computing Architecture (ATCA) was chosen to design, develop, and build a Low Level Radio Frequency (LLRF) controller for X-FEL. The prototype control system for Lorentz force detuning compensation was designed and developed. The control applications applied in the system were fitted to the main framework of interfaces and communication protocols proposed for the ATCA-based LLRF control system. The paper presents the general view of a designed control system and shows the first experimental results from the tests carried out in FLASH facility. Moreover, the possibilities for integration of the piezo control system to the ATCA standards are discussed.

A Scalable proxy cache for Grid Data Access

NASA Astrophysics Data System (ADS)

Cristian Cirstea, Traian; Just Keijser, Jan; Koeroo, Oscar Arthur; Starink, Ronald; Templon, Jeffrey Alan

2012-12-01

We describe a prototype grid proxy cache system developed at Nikhef, motivated by a desire to construct the first building block of a future https-based Content Delivery Network for grid infrastructures. Two goals drove the project: firstly to provide a “native view” of the grid for desktop-type users, and secondly to improve performance for physics-analysis type use cases, where multiple passes are made over the same set of data (residing on the grid). We further constrained the design by requiring that the system should be made of standard components wherever possible. The prototype that emerged from this exercise is a horizontally-scalable, cooperating system of web server / cache nodes, fronted by a customized webDAV server. The webDAV server is custom only in the sense that it supports http redirects (providing horizontal scaling) and that the authentication module has, as back end, a proxy delegation chain that can be used by the cache nodes to retrieve files from the grid. The prototype was deployed at Nikhef and tested at a scale of several terabytes of data and approximately one hundred fast cores of computing. Both small and large files were tested, in a number of scenarios, and with various numbers of cache nodes, in order to understand the scaling properties of the system. For properly-dimensioned cache-node hardware, the system showed speedup of several integer factors for the analysis-type use cases. These results and others are presented and discussed.

SMART on FHIR: a standards-based, interoperable apps platform for electronic health records

PubMed Central

Kreda, David A; Mandl, Kenneth D; Kohane, Isaac S; Ramoni, Rachel B

2016-01-01

Objective In early 2010, Harvard Medical School and Boston Children’s Hospital began an interoperability project with the distinctive goal of developing a platform to enable medical applications to be written once and run unmodified across different healthcare IT systems. The project was called Substitutable Medical Applications and Reusable Technologies (SMART). Methods We adopted contemporary web standards for application programming interface transport, authorization, and user interface, and standard medical terminologies for coded data. In our initial design, we created our own openly licensed clinical data models to enforce consistency and simplicity. During the second half of 2013, we updated SMART to take advantage of the clinical data models and the application-programming interface described in a new, openly licensed Health Level Seven draft standard called Fast Health Interoperability Resources (FHIR). Signaling our adoption of the emerging FHIR standard, we called the new platform SMART on FHIR. Results We introduced the SMART on FHIR platform with a demonstration that included several commercial healthcare IT vendors and app developers showcasing prototypes at the Health Information Management Systems Society conference in February 2014. This established the feasibility of SMART on FHIR, while highlighting the need for commonly accepted pragmatic constraints on the base FHIR specification. Conclusion In this paper, we describe the creation of SMART on FHIR, relate the experience of the vendors and developers who built SMART on FHIR prototypes, and discuss some challenges in going from early industry prototyping to industry-wide production use. PMID:26911829

A prototype of injector to control and to detect the release of magnetic beads within the constraints of multibifurcation magnetic resonance navigation procedures.

PubMed

Bigot, Alexandre; Soulez, Gilles; Martel, Sylvain

2017-01-01

An injector equipped with a bead capture and a bead detection system is presented. In the context of magnetic resonance navigation (MRN), in which MRI gradients are used to steer intravascular therapeutic carriers, fast and reliable injection is essential. In this paper, we present a prototype of injector to control and to detect the release of magnetic beads. The injector relies on two distinct subsystems: (1) the capture subsystem, which creates local magnetic force to stop the flow of magnetic beads; and (2) the detection subsystem, which detects flowing beads and generates a trigger signal to start MRI gradient pulses. Both systems rely on small microcoils wound on the tubing. Five-turn microcoils show the best compromise between size and performance. Less than 5 mW of power is required to capture 0.8-mm beads moving in a flow above 5 mL min -1 or when a gradient above 200 mT m -1 is applied. The detection system is not sensitive to noise and detects every 0.8-mm bead in flow rates up to 14 mL m -1 . The prototype of injector shows performance above the requirements inherent to magnetic resonance navigation. This system is a step toward in vivo multibifurcation MRN. Magn Reson Med 77:444-452, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Progress in recognizing typeset mathematics

NASA Astrophysics Data System (ADS)

Fateman, Richard J.; Tokuyasu, Taku A.

1996-03-01

Printed mathematics has a number of features which distinguish it from conventional text. These include structure in two dimensions (fractions, exponents, limits), frequent font changes, symbols with variable shape (quotient bars), and substantially differing notational conventions from source to source. When compounded with more generic problems such as noise and merged or broken characters, printed mathematics offers a challenging arena for recognition. Our project was initially driven by the goal of scanning and parsing some 5,000 pages of elaborate mathematics (tables of definite integrals). While our prototype system demonstrates success on translating noise-free typeset equations into Lisp expressions appropriate for further processing, a more semantic top-down approach appears necessary for higher levels of performance. Such an approach may benefit the incorporation of these programs into a more general document processing viewpoint. We intend to release to the public our somewhat refined prototypes as utility programs in the hope that they will be of general use in the construction of custom OCR packages. These utilities are quite fast even as originally prototyped in Lisp, where they may be of particular interest to those working on 'intelligent' optical processing. Some routines have been re-written in C++ as well. Additional programs providing formula recognition and parsing also form a part of this system. It is important however to realize that distinct conflicting grammars are needed to cover variations in contemporary and historical typesetting, and thus a single simple solution is not possible.

Recent developments in PET detector technology

PubMed Central

Lewellen, Tom K

2010-01-01

Positron emission tomography (PET) is a tool for metabolic imaging that has been utilized since the earliest days of nuclear medicine. A key component of such imaging systems is the detector modules—an area of research and development with a long, rich history. Development of detectors for PET has often seen the migration of technologies, originally developed for high energy physics experiments, into prototype PET detectors. Of the many areas explored, some detector designs go on to be incorporated into prototype scanner systems and a few of these may go on to be seen in commercial scanners. There has been a steady, often very diverse development of prototype detectors, and the pace has accelerated with the increased use of PET in clinical studies (currently driven by PET/CT scanners) and the rapid proliferation of pre-clinical PET scanners for academic and commercial research applications. Most of these efforts are focused on scintillator-based detectors, although various alternatives continue to be considered. For example, wire chambers have been investigated many times over the years and more recently various solid-state devices have appeared in PET detector designs for very high spatial resolution applications. But even with scintillators, there have been a wide variety of designs and solutions investigated as developers search for solutions that offer very high spatial resolution, fast timing, high sensitivity and are yet cost effective. In this review, we will explore some of the recent developments in the quest for better PET detector technology. PMID:18695301

Real-time notification and improved situational awareness in fire emergencies using geospatial-based publish/subscribe

NASA Astrophysics Data System (ADS)

Kassab, Ala'; Liang, Steve; Gao, Yang

2010-12-01

Emergency agencies seek to maintain situational awareness and effective decision making through continuous monitoring of, and real-time alerting about, sources of information regarding current incidents and developing fire hazards. The nature of this goal requires integrating different, potentially numerous, sources of dynamic geospatial information on the one side, and a large number of clients having heterogeneous and specific interests in data on the other side. In such scenarios, the traditional request/reply communication style may function inefficiently, as it is based on point-to-point, synchronous, and pulling mode interaction between consumer clients and information providers/services. In this work, we propose Geospatial-based Publish/ Subscribe, an interaction framework that serves as a middleware for real-time transacting of spatially related information of interest, termed geospatial events, in distributed systems. Expressive data models, including geospatial event and geospatial subscription, as well as an efficient matching approach for fast dissemination of geospatial events to interested clients, are introduced. The proposed interaction framework is realized through the development of a Real-Time Fire Emergency Response System (RFERS) prototype. The prototype is designed for transacting several topics of geospatial events that are crucial within the context of fire emergencies, including GPS locations of emergency assets, meteorological observations of wireless sensors, fire incidents reports, and temporal sequences of remote sensing images of active wildfires. The performance of the system prototype has been evaluated in order to demonstrate its efficiency.

A Suggested Curriculum Outline for German in Secondary Schools

ERIC Educational Resources Information Center

Clutterbuck, J. M.

1975-01-01

Outlines a four-year program of German study aiming to give students a basic ability in spoken and written German, knowledge of German culture, and preparation for advanced German study. Study topics and textbooks are included. (CHK)

Die Deutschen in Wisconsin (Germans in Wisconsin).

ERIC Educational Resources Information Center

Wisconsin State Dept. of Public Instruction, Madison.

The following curriculum units comprise this course book: (1) Germans in a New Home, (2) Contributions of the Germans in Wisconsin, (3) A Letter to Germany, (4) Germans Come to Kingston, (5) First a Soldier, Then a Man of the Church (about Heinrich von Rohr), (6) A Visiting German, and (7) Germans and Music. Each unit begins with a reading of…

Fast and Adaptive Lossless On-Board Hyperspectral Data Compression System for Space Applications

NASA Technical Reports Server (NTRS)

Aranki, Nazeeh; Bakhshi, Alireza; Keymeulen, Didier; Klimesh, Matthew

2009-01-01

Efficient on-board lossless hyperspectral data compression reduces the data volume necessary to meet NASA and DoD limited downlink capabilities. The techniques also improves signature extraction, object recognition and feature classification capabilities by providing exact reconstructed data on constrained downlink resources. At JPL a novel, adaptive and predictive technique for lossless compression of hyperspectral data was recently developed. This technique uses an adaptive filtering method and achieves a combination of low complexity and compression effectiveness that far exceeds state-of-the-art techniques currently in use. The JPL-developed 'Fast Lossless' algorithm requires no training data or other specific information about the nature of the spectral bands for a fixed instrument dynamic range. It is of low computational complexity and thus well-suited for implementation in hardware, which makes it practical for flight implementations of pushbroom instruments. A prototype of the compressor (and decompressor) of the algorithm is available in software, but this implementation may not meet speed and real-time requirements of some space applications. Hardware acceleration provides performance improvements of 10x-100x vs. the software implementation (about 1M samples/sec on a Pentium IV machine). This paper describes a hardware implementation of the JPL-developed 'Fast Lossless' compression algorithm on a Field Programmable Gate Array (FPGA). The FPGA implementation targets the current state of the art FPGAs (Xilinx Virtex IV and V families) and compresses one sample every clock cycle to provide a fast and practical real-time solution for Space applications.

FAST - FREEDOM ASSEMBLY SEQUENCING TOOL PROTOTYPE

NASA Technical Reports Server (NTRS)

Borden, C. S.

1994-01-01

FAST is a project management tool designed to optimize the assembly sequence of Space Station Freedom. An appropriate assembly sequence coordinates engineering, design, utilization, transportation availability, and operations requirements. Since complex designs tend to change frequently, FAST assesses the system level effects of detailed changes and produces output metrics that identify preferred assembly sequences. FAST incorporates Space Shuttle integration, Space Station hardware, on-orbit operations, and programmatic drivers as either precedence relations or numerical data. Hardware sequencing information can either be input directly and evaluated via the "specified" mode of operation or evaluated from the input precedence relations in the "flexible" mode. In the specified mode, FAST takes as its input a list of the cargo elements assigned to each flight. The program determines positions for the cargo elements that maximize the center of gravity (c.g.) margin. These positions are restricted by the geometry of the cargo elements and the location of attachment fittings both in the orbiter and on the cargo elements. FAST calculates every permutation of cargo element location according to its height, trunnion fitting locations, and required intercargo element spacing. Each cargo element is tested in both its normal and reversed orientation (rotated 180 degrees). The best solution is that which maximizes the c.g. margin for each flight. In the flexible mode, FAST begins with the first flight and determines all feasible combinations of cargo elements according to mass, volume, EVA, and precedence relation constraints. The program generates an assembly sequence that meets mass, volume, position, EVA, and precedence constraints while minimizing the total number of Shuttle flights required. Issues associated with ground operations, spacecraft performance, logistics requirements and user requirements will be addressed in future versions of the model. FAST is written in C-Language and has been implemented on DEC VAX series computers running VMS. The program is distributed in executable form. The source code is also provided, but it cannot be compiled without the Tree Manipulation Based Routines (TMBR) package from the Jet Propulsion Laboratory, which is not currently available from COSMIC. The main memory requirement is based on the data used to drive the FAST program. All applications should easily run on an installation with 10Mb of main memory. FAST was developed in 1990 and is a copyrighted work with all copyright vested in NASA. DEC, VAX and VMS are trademarks of Digital Equipment Corporation.

Black hole outflows from Centaurus A detected with APEX

NASA Astrophysics Data System (ADS)

2009-01-01

Astronomers have a new insight into the active galaxy Centaurus A (NGC 5128), as the jets and lobes emanating from the central black hole have been imaged at submillimetre wavelengths for the first time. The new data, from the Atacama Pathfinder Experiment (APEX) telescope in Chile, which is operated by ESO, have been combined with visible and X-ray wavelengths to produce this striking new image. ESO PR Photo 03a/09 Centaurus A Centaurus A is our nearest giant galaxy, at a distance of about 13 million light-years in the southern constellation of Centaurus. It is an elliptical galaxy, currently merging with a companion spiral galaxy, resulting in areas of intense star formation and making it one of the most spectacular objects in the sky. Centaurus A hosts a very active and highly luminous central region, caused by the presence of a supermassive black hole (see ESO 04/01), and is the source of strong radio and X-ray emission. In the image, we see the dust ring encircling the giant galaxy, and the fast-moving radio jets ejected from the galaxy centre, signatures of the supermassive black hole at the heart of Centaurus A. In submillimetre light, we see not only the heat glow from the central dust disc, but also the emission from the central radio source and - for the first time in the submillimetre - the inner radio lobes north and south of the disc. Measurements of this emission, which occurs when fast-moving electrons spiral around the lines of a magnetic field, reveal that the material in the jet is travelling at approximately half the speed of light. In the X-ray emission, we see the jets emerging from the centre of Centaurus A and, to the lower right of the galaxy, the glow where the expanding lobe collides with the surrounding gas, creating a shockwave. The Large APEX Bolometer Camera (LABOCA), built by the Max-Planck-Institute for Radio Astronomy (MPIfR), is mounted on APEX, a 12-metre diameter submillimetre-wavelength telescope located on the 5000 m high plateau of Chajnantor in the Chilean Atacama region. APEX is a collaboration between the MPIfR, the Onsala Space Observatory and ESO. The telescope is based on a prototype antenna constructed for the next generation Atacama Large Millimeter/submillimeter Array (ALMA) project. Operation of APEX at Chajnantor is entrusted to ESO. The APEX observations of Centaurus A are presented in the paper by Axel Weiss et al. 2008, LABOCA observations of nearby, active galaxies, A&A, 490, 77-86. A German-language page about this image, "Radiosignale aus der Richtung des Schwarzen Lochs im Zentrum von Centaurus A", is available on the MPIfR website.

A fast method for optical simulation of flood maps of light-sharing detector modules

PubMed Central

Shi, Han; Du, Dong; Xu, JianFeng; Moses, William W.; Peng, Qiyu

2016-01-01

Optical simulation of the detector module level is highly desired for Position Emission Tomography (PET) system design. Commonly used simulation toolkits such as GATE are not efficient in the optical simulation of detector modules with complicated light-sharing configurations, where a vast amount of photons need to be tracked. We present a fast approach based on a simplified specular reflectance model and a structured light-tracking algorithm to speed up the photon tracking in detector modules constructed with polished finish and specular reflector materials. We simulated conventional block detector designs with different slotted light guide patterns using the new approach and compared the outcomes with those from GATE simulations. While the two approaches generated comparable flood maps, the new approach was more than 200–600 times faster. The new approach has also been validated by constructing a prototype detector and comparing the simulated flood map with the experimental flood map. The experimental flood map has nearly uniformly distributed spots similar to those in the simulated flood map. In conclusion, the new approach provides a fast and reliable simulation tool for assisting in the development of light-sharing-based detector modules with a polished surface finish and using specular reflector materials. PMID:27660376

Irradiation creep of various ferritic alloys irradiated at {approximately}400{degrees}C in the PFR and FFTF reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toloczko, M.B.; Garner, F.A.; Eiholzer, C.R.

1997-04-01

Three ferritic alloys were irradiated in two fast reactors to doses of 50 dpa or more at temperatures near 400{degrees}C. One martensitic alloy, HT9, was irradiated in both the FFTF and PFR reactors. PFR is the Prototype Fast Reactor in Dourneay, Scotland, and FFTF is the Fast Flux Test Facility in Richland, WA. D57 is a developmental alloy that was irradiated in PFR only, and MA957 is a Y{sub 2}O{sub 3} dispersion-hardened ferritic alloy that was irradiated only in FFTF. These alloys exhibited little or no void swelling at {approximately}400{degrees}C. Depending on the alloy starting condition, these steels develop amore » variety of non-creep strains early in the irradiation that are associated with phase changes. Each of these alloys creeps at a rate that is significantly lower than that of austenitic steels irradiated in the same experiments. The creep compliance for ferritic alloys in general appears to be {approximately}0.5 x 10{sup {minus}6} MPa{sup {minus}1} dpa{sup {minus}1}, independent of both composition and starting state. The addition of Y{sub 2}O{sub 3} as a dispersoid does not appear to change the creep behavior.« less

A fast method for optical simulation of flood maps of light-sharing detector modules

DOE PAGES

Shi, Han; Du, Dong; Xu, JianFeng; ...

2015-09-03

Optical simulation of the detector module level is highly desired for Position Emission Tomography (PET) system design. Commonly used simulation toolkits such as GATE are not efficient in the optical simulation of detector modules with complicated light-sharing configurations, where a vast amount of photons need to be tracked. Here, we present a fast approach based on a simplified specular reflectance model and a structured light-tracking algorithm to speed up the photon tracking in detector modules constructed with polished finish and specular reflector materials. We also simulated conventional block detector designs with different slotted light guide patterns using the new approachmore » and compared the outcomes with those from GATE simulations. And while the two approaches generated comparable flood maps, the new approach was more than 200–600 times faster. The new approach has also been validated by constructing a prototype detector and comparing the simulated flood map with the experimental flood map. The experimental flood map has nearly uniformly distributed spots similar to those in the simulated flood map. In conclusion, the new approach provides a fast and reliable simulation tool for assisting in the development of light-sharing-based detector modules with a polished surface finish and using specular reflector materials.« less

Fast multichannel astronomical photometer based on silicon photo multipliers mounted at the Telescopio Nazionale Galileo

NASA Astrophysics Data System (ADS)

Ambrosino, Filippo; Meddi, Franco; Rossi, Corinne; Sclavi, Silvia; Nesci, Roberto; Bruni, Ivan; Ghedina, Adriano; Riverol, Luis; Di Fabrizio, Luca

2014-07-01

The realization of low-cost instruments with high technical performance is a goal that deserves efforts in an epoch of fast technological developments. Such instruments can be easily reproduced and therefore allow new research programs to be opened in several observatories. We realized a fast optical photometer based on the SiPM (Silicon Photo Multiplier) technology, using commercially available modules. Using low-cost components, we developed a custom electronic chain to extract the signal produced by a commercial MPPC (Multi Pixel Photon Counter) module produced by Hamamatsu Photonics to obtain sub-millisecond sampling of the light curve of astronomical sources (typically pulsars). We built a compact mechanical interface to mount the MPPC at the focal plane of the TNG (Telescopio Nazionale Galileo), using the space available for the slits of the LRS (Low Resolution Spectrograph). On February 2014 we observed the Crab pulsar with the TNG with our prototype photometer, deriving its period and the shape of its light curve, in very good agreement with the results obtained in the past with other much more expensive instruments. After the successful run at the telescope we describe here the lessons learned and the ideas that burst to optimize this instrument and make it more versatile.

Full characterization of laser-accelerated ion beams using Faraday cup, silicon carbide, and single-crystal diamond detectors

NASA Astrophysics Data System (ADS)

Margarone, D.; Krása, J.; Giuffrida, L.; Picciotto, A.; Torrisi, L.; Nowak, T.; Musumeci, P.; Velyhan, A.; Prokůpek, J.; Láska, L.; Mocek, T.; Ullschmied, J.; Rus, B.

2011-05-01

Multi-MeV beams of light ions have been produced using the 300 picosecond, kJ-class iodine laser, operating at the Prague Asterix Laser System facility in Prague. Real-time ion diagnostics have been performed by the use of various time-of-flight (TOF) detectors: ion collectors (ICs) with and without absorber thin films, new prototypes of single-crystal diamond and silicon carbide detectors, and an electrostatic ion mass spectrometer (IEA). In order to suppress the long photopeak induced by soft X-rays and to avoid the overlap with the signal from ultrafast particles, the ICs have been shielded with Al foil filters. The application of large-bandgap semiconductor detectors (>3 eV) ensured cutting of the plasma-emitted visible and soft-UV radiation and enhancing the sensitivity to the very fast proton/ion beams. Employing the IEA spectrometer, various ion species and charge states in the expanding laser-plasma have been determined. Processing of the experimental data based on the TOF technique, including estimation of the plasma fast proton maximum and peak energy, ion beam currents and total charge, total number of fast protons, as well as deconvolution processes, ion stopping power, and ion/photon transmission calculations for the different metallic filters used, are reported.

Measurement of specific medical school stress: translation of the "Perceived Medical School Stress Instrument" to the German language.

PubMed

Kötter, Thomas; Voltmer, Edgar

2013-01-01

Medical students encounter specific stressors during their studies. As a result, they develop anxiety, depression and burnout symptoms more frequently than their similarly aged, but employed counterparts. In 1984, Vitaliano et al. published a 13-item instrument for the measurement of stress specific to medical school: the "Perceived Medical School Stress Instrument" (PMSS). Since then, it has been widely applied and validated in English-speaking countries. No German version of the PMSS exists to date. Thus, our aim was to translate the instrument into the German language in order to be able to measure medical school stress in German-speaking countries. The items of the PMSS were translated into German by three separate researchers. The resulting translations were compared and combined with each other to establish a first German version of each item in the PMSS. These items were then translated back into English by two native English speakers to validate the correct primary translation. Based on a revised German version, a cognitive debriefing with 19 German medical students and a theoretical testing on 169 German medical students, the final German translations for each of the 13 items were determined. The PMSS was easily translated into German and there was a high congruency between the primary translations into German and the secondary translations back into English. Incongruities between the translations were solved quickly. The assessment of the German equivalent of the PMSS showed good results regarding its reliability (Cronbach's Alpha 0.81). A German version of the PMSS is now available for measuring the medical school related stress in German-speaking countries.

Beating the Heat: Fast Scanning Melts Beta Sheet Crystals

NASA Astrophysics Data System (ADS)

Cebe, Peggy; Hu, Xiao; Kaplan, David; Zhuravlev, Evgeny; Wurm, Andreas; Arbeiter, Daniella; Schick, Christoph

2014-03-01

Beta-pleated-sheet crystals are among the most stable of protein secondary structures, and are responsible for the remarkable physical properties of many fibrous proteins, such as silk. Previous thinking was that beta-pleated-sheet crystals in the dry solid state would not melt upon input of heat energy alone. Indeed, at conventional heating rates (~1-50 °C/min), silk exhibits its glass transition (~175 °C), followed by cold crystallization, and then by immediate thermal degradation beginning at about 225 °C. Here we demonstrate that beta-pleated-sheet crystals can melt directly from the solid state to become random coils, helices, and turns. We use fast scanning chip calorimetry at 2,000 K/s to avoid thermal degradation, and report the first reversible thermal melting of protein beta-pleated-sheet crystals, exemplified by silk fibroin. The similarity between thermal melting behavior of lamellar crystals of synthetic polymers and beta-pleated-sheet crystals is confirmed. The authors acknowledge support from the National Science Foundation and German Academic Exchange Service DAAD; EZ acknowledges a European Union funded Marie Curie EST fellowship (ADVATEC); XH and DK acknowledge NIH P41 Tissue Engineering Resource Center.

German Studies in America. German Studies Notes.

ERIC Educational Resources Information Center

Sander, Volkmar; Osterle, Heinz D.

This volume contains two papers, "German Studies in America," by Volkmar Sander, and "Historicism, Marxism, Structuralism: Ideas for German Culture Courses," by Heinz D. Osterle. The first paper discusses the position of German studies in the United States today. The greatest challenge comes from low enrollments; therefore,…

Strategic positioning of the ERATOSTHENES Research Centre for atmospheric remote sensing research in the Eastern Mediterranean and Middle East region

NASA Astrophysics Data System (ADS)

Mamouri, Rodanthi-Elisavet; Ansmann, Albert; Hadjimitsis, Diofantos G.; Nisantzi, Argyro; Bühl, Johannes; Michaelides, Silas; Seifert, Patric; Engelmann, Ronny; Wandinger, Ulla; Kontoes, Charalampos; Schreier, Gunter; Komodromos, Georgios; Themistocleous, Kyriacos

2017-10-01

The aim of this article is to present the importance of a permanent state-of-the-art atmospheric remote sensing ground based station in the region of the Eastern Mediterranean and Middle East (EMME). The ERATOSTHENES Research Centre (ERC) with the vision to become a Centre of Excellence for Earth Surveillance and Space-Based Monitoring of the Environment (EXCELSIOR H2020: Teaming project) already operates (within Phase 1) a fully established EARLINETt-Cloudnet supersite at Limassol, Cyprus, for a period of 2 years, in close collaboration with the German Leibniz Institute for Tropospheric Research (TROPOS), The scientific aspects of this prototype-like field campaign CyCARE (Cyprus Cloud Aerosol and Rain Experiment) - a common initiative between the Cyprus University of Technology (CUT), Limassol and TROPOS- are presented in this paper. Cy-CARE has been designed by TROPOS and CUT to fill a gap in the understanding of aerosol-cloud interaction in one of the key regions of climate change and how precipitation formation is influenced by varying aerosol/pollution and meteorological conditions The guiding questions are: How may rain patterns change in future and what may be the consequences of climate change in arid regions such as EMME. EXCELSIOR is a team effort between CUT (acting as the coordinator), the German Aerospace Centre (DLR), the Institute for Astronomy and Astrophysics Space Applications and Remote Sensing of the National Observatory of Athens (NOA), TROPOS and the Cyprus Department of Electronic Communications of the Ministry of Transport, Communications and Works (DEC-MTCW) who will work together to improve the network structures significantly, resulting in Cyprus being regarded as a cornerstone of a European Network of active remote sensing of the atmosphere.

Prototypic Development and Evaluation of a Medium Format Metric Camera

NASA Astrophysics Data System (ADS)

Hastedt, H.; Rofallski, R.; Luhmann, T.; Rosenbauer, R.; Ochsner, D.; Rieke-Zapp, D.

2018-05-01

Engineering applications require high-precision 3D measurement techniques for object sizes that vary between small volumes (2-3 m in each direction) and large volumes (around 20 x 20 x 1-10 m). The requested precision in object space (1σ RMS) is defined to be within 0.1-0.2 mm for large volumes and less than 0.01 mm for small volumes. In particular, focussing large volume applications the availability of a metric camera would have different advantages for several reasons: 1) high-quality optical components and stabilisations allow for a stable interior geometry of the camera itself, 2) a stable geometry leads to a stable interior orientation that enables for an a priori camera calibration, 3) a higher resulting precision can be expected. With this article the development and accuracy evaluation of a new metric camera, the ALPA 12 FPS add|metric will be presented. Its general accuracy potential is tested against calibrated lengths in a small volume test environment based on the German Guideline VDI/VDE 2634.1 (2002). Maximum length measurement errors of less than 0.025 mm are achieved with different scenarios having been tested. The accuracy potential for large volumes is estimated within a feasibility study on the application of photogrammetric measurements for the deformation estimation on a large wooden shipwreck in the German Maritime Museum. An accuracy of 0.2 mm-0.4 mm is reached for a length of 28 m (given by a distance from a lasertracker network measurement). All analyses have proven high stabilities of the interior orientation of the camera and indicate the applicability for a priori camera calibration for subsequent 3D measurements.

Effectiveness of rehabilitation after a total hip arthroplasty: a protocol for an observational study for the comparison of usual care in the Netherlands versus Germany.

PubMed

Seeber, Gesine H; Wijnen, Annet; Lazovic, Djordje; Bulstra, Sjoerd K; Dietz, Günter; van Lingen, Christiaan P; Stevens, Martin

2017-08-11

Osteoarthritis is the most common joint disorder worldwide. Total hip arthroplasty (THA) is considered one of the most effective treatments for end-stage hip osteoarthritis. The number of THAs is expected to increase dramatically in the coming decades. Usual postoperative rehabilitation after primary THA differs between the German and the Dutch system. In the Netherlands, patients undergo fast-track surgery and are discharged into their home environment within a few days without receiving any aftercare. In Germany, patients stay in the hospital for about 12 days before being transferred to a rehabilitation centre for a period of 3 weeks. The superficially more cost-effective Dutch system of usual care after THA is judged critically in both countries due to suboptimal rehabilitation outcomes. The aim of this study is therefore to compare the Dutch with the German usual care rehabilitation after primary THA. It is hypothesised that the German procedure is more effective in terms of functional outcomes and patient satisfaction than the Dutch procedure and that in the long run the German approach is more cost-effective than the Dutch system. Medical effectiveness will be assessed at four different time points by means of patient self-reported questionnaires and functional tests. Assessments include the Hip disability and Osteoarthritis Outcome Score, Patient Acceptable Symptom State, Short Form 36, EuroQol 5 Dimensions 3 Level Questionnaire, Timed Up & Go Test and Five Times Sit-to-Stand Test. Additionally, long-term economic aspects in both countries will be assessed from a societal perspective, to get a first impression on whether cutting costs for rehabilitation, as practised in the Netherlands, really disburdens the healthcare system efficiently. The study is approved by the Institutional Review Boards of both University Medical Center Groningen (METc2015/483) and Hannover Medical School (no 2874-2015) and will be conducted according to the principles of the Declaration of Helsinki (64th, 2013). The results of the study will be published in international peer-reviewed scientific journals. Patient data will be presented anonymously in any publication or scientific journal. DRKS00011345; Pre-results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Astrobo: Towards a new observatory control system for the Garching Observatory 0.6m

NASA Astrophysics Data System (ADS)

Schweyer, T.; Jarmatz, P.; Burwitz, V.

2016-12-01

The recently installed Campus Observatory Garching (COG) 0.6m telescope features a wide array of instruments, including a wide-field imager and a variety of spectrographs. To support all these different instruments and improve time usage, it was decided to develop a new control system from scratch, that will be able to safely observe autonomously as well as manually (for student lab courses). It is built using an hierarchical microservice architecture, which allows well-specified communication between its components regardless of the programming language used. This modular design allows for fast prototyping of components as well as easy implementation of complex instrumentation control software.

Characterization of the ETEL D784UKFLB 11 in. photomultiplier tube

NASA Astrophysics Data System (ADS)

Barros, N.; Kaptanoglu, T.; Kimelman, B.; Klein, J. R.; Moore, E.; Nguyen, J.; Stavreva, K.; Svoboda, R.

2017-04-01

Water Cherenkov and scintillator detectors are a critical tool for neutrino physics. Their large size, low threshold, and low operational cost make them excellent detectors for long baseline neutrino oscillations, proton decay, supernova and solar neutrinos, double beta decay, and ultra-high energy astrophysical neutrinos. Proposals for a new generation of large detectors rely on the availability of large format, fast, cost-effective photomultiplier tubes. The Electron Tubes Enterprises, Ltd (ETEL) D784KFLB 11 in. Photomultiplier Tube has been developed for large neutrino detectors. We have measured the timing characteristics, relative efficiency, and magnetic field sensitivity of the first fifteen prototypes.

A Surface Science Paradigm for a Post-Huygens Titan Mission

NASA Technical Reports Server (NTRS)

Zimmerman, Wayne; Lunine, Jonathan; Lorenz, Ralph

2004-01-01

With the Cassini-Huygens atmospheric probe drop-off mission fast approaching, it is essential that scientists and engineers start scoping potential follow-on surface science missions. This paper provides a summary of the first year of a two year design study which examines in detail the desired surface science measurements and resolution, potential instrument suite, and complete payload delivery system. Also provided are design concepts for both an aerial inflatable mobility platform and deployable instrument sonde. The tethered deployable sonde provides the capability to sample nearsurface atmosphere, sub-surface liquid (if it exists), and surface solid material. Actual laboratory tests of the amphibious sonde prototype are also presented.

Fast hyper-spectral imaging of cytological samples in the mid-infrared wavelength region

NASA Astrophysics Data System (ADS)

Farries, Mark; Ward, Jon; Lindsay, Ian; Nallala, Jayakrupakar; Moselund, Peter

2017-02-01

A prototype mid-infrared spectral imaging system for rapid assessment of cells for cytological diagnosis is reported. Based on a fibre optic super-continuum source that has large spectral brightness and is coupled in to an acousto-optic tuneable filter that can rapidly scan over a set of wavelengths that are chosen to give a high level of selectivity for a specific skin disease. The system has the potential to collect an image cube of 100 wavelengths and 300k pixels in 2 seconds so that cells on living people could be analysed. The system has been evaluated with colon cells over 2700- 3100 cm-1.

Hyperspectral retrieval of surface reflectances: A new scheme

NASA Astrophysics Data System (ADS)

Thelen, Jean-Claude; Havemann, Stephan

2013-05-01

Here, we present a new prototype algorithm for the simultaneous retrieval of the atmospheric profiles (temperature, humidity, ozone and aerosol) and the surface reflectance from hyperspectral radiance measurements obtained from air/space borne, hyperspectral imagers. The new scheme, proposed here, consists of a fast radiative transfer code, based on empirical orthogonal functions (EOFs), in conjunction with a 1D-Var retrieval scheme. The inclusion of an 'exact' scattering code based on spherical harmonics, allows for an accurate treatment of Rayleigh scattering and scattering by aerosols, water droplets and ice-crystals, thus making it possible to also retrieve cloud and aerosol optical properties, although here we will concentrate on non-cloudy scenes.

Observation of Air Shower in Uijeongbu Area using the COREA Prototype Detector System

NASA Astrophysics Data System (ADS)

Cho, Wooram; Shin, Jae-ik; Kwon, Youngjoon; Yang, Jongmann; Nam, Shinwoo; Park, Il H.; Cheon, ByungGu; Kim, Hang Bae; Bhang, Hyoung Chan; Park, Cheolyoung; Kim, Gyhyuk; Choi, Wooseok; Hwang, MyungJin; Shin, Gwangsik

2018-06-01

We report the study of high energy cosmic rays in Uijeongbu area using a cosmic-ray detector array system. The array consists of three detector stations, each of which contains a set of three scintillators and PMTs, a GPS antenna along with data acquisition system. To identify air shower signals originating from a single cosmic ray, time coincidence information is used. We devised a method for estimating the energy range of air shower data detected by an array of only three detectors, using air shower simulation and citing already known energy spectrum. Also, Fast Fourier Transform(FFT) was applied to study isotropy.

Use of acousto-optic tunable filter in fluorescence imaging endoscopy

NASA Astrophysics Data System (ADS)

Bouhifd, Mounir; Whelan, Maurice; Aprahamian, Marc

2003-10-01

A prototype instrument for fluorescence-based medical diagnostics in vivo is described. The system consists of a rigid endoscope comprising a UV laser-source for fluorescence excitation and a white light source for direct imaging. An acousto-optic tuneable filter (AOTF) is employed as a full-field tuneable bandpass filter. This allows fast continuous or random-access tuning with high filtering efficiency. A study of the diagnostic potential of fluorescence imaging for pancreatitis was conducted on a rat model. In particular, the aim was to detect autofluorescence of endogenous protoporphyrin IX (PpIX) that has been shown to accumulate in early-stage diseased tissue undergoing an inflammatory response.

A Surface Science Paradigm for a Post-Huygens Titan Mission

NASA Technical Reports Server (NTRS)

Zimmerman, Wayne F.; Lunine, Jonathan; Lorenz, Ralph

2005-01-01

With the Cassini-Huygens atmospheric probe drop-off mission fast approaching, it is essential that scientists and engineers start scoping potential follow-on surface science missions. This paper provides a summary of the first year of a two year design study which examines in detail the desired surface science measurements and resolution, potential instrument suite, and complete payload delivery system. Also provided are design concepts for both an aerial inflatable mobility platform and deployable instrument sonde. The tethered deployable sonde provides the capability to sample near surface atmosphere, sub-surface liquid (if it exists), and surface solid material. Actual laboratory tests of the amphibious sonde prototype are also presented.

Actinomadura Species: Laboratory Maintenance and Ribosome Engineering.

PubMed

Dhakal, Dipesh; Chung, Nguyen Thanh; Rayamajhi, Vijay; Sohng, Jae Kyung

2017-02-06

Actinomadura spp. are aerobic, Gram-positive, catalase-positive, non-acid fast, non-motile actinomycetes. Some species of Actinomadura are associated with opportunistic infections in humans. However, many bioactive compounds with pharmaceutical applications can be isolated from various Actinomadura spp. This unit includes general protocols for the laboratory maintenance of Actinomadura spp., including growth in liquid medium, growth on solid agar, long-term storage, and generation of a higher producing strain by ribosome engineering. Actinomadura hibisca P157-2 is used as a prototype for explaining the considerations for efficient laboratory maintenance of Actinomadura spp. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc.

Multiprocessor and memory architecture of the neurocomputer SYNAPSE-1.

PubMed

Ramacher, U; Raab, W; Anlauf, J; Hachmann, U; Beichter, J; Brüls, N; Wesseling, M; Sicheneder, E; Männer, R; Glass, J

1993-12-01

A general purpose neurocomputer, SYNAPSE-1, which exhibits a multiprocessor and memory architecture is presented. It offers wide flexibility with respect to neural algorithms and a speed-up factor of several orders of magnitude--including learning. The computational power is provided by a 2-dimensional systolic array of neural signal processors. Since the weights are stored outside these NSPs, memory size and processing power can be adapted individually to the application needs. A neural algorithms programming language, embedded in C(+2) has been defined for the user to cope with the neurocomputer. In a benchmark test, the prototype of SYNAPSE-1 was 8000 times as fast as a standard workstation.

DESCANT - Testing and Commissioning

NASA Astrophysics Data System (ADS)

Bildstein, Vinzenz; Garrett, P. E.; Bandyopadhay, D.; Bangay, J.; Bianco, L.; Demand, G.; Hadinia, B.; Leach, K. G.; Sumithrarachchi, C.; Turko, J.; Wong, J.; Ashley, S. F.; Crider, B. P.; McEllistrem, M. T.; Peters, E. E.; Prados-Estévez, F. M.; Yates, S. W.; Vanhoy, J. R.; Ball, G. C.; Bishop, D. P.; Garnsworthy, A. B.; Hackman, G.; Pearson, C. J.; Shaw, B.; Sarazin, F.

2017-09-01

The DESCANT array at TRIUMF is designed to detect neutrons from RIB experiments. DESCANT is composed of 70 close-packed deuterated organic liquid scintillators coupled to digital fast read-out ADC modules. This configuration permits online pulse-shape discrimination between neutron and γ-ray events. A prototype detector was tested with monoenergetic neutrons at the University of Kentucky Accelerator Laboratory. The data from these tests was compared to Geant4 simulations. A first commissioning experiment of the full array, using the decay of Cs 145 - 146 , was performed in August 2016. The results of the tests and a preliminary analysis of the commissioning experiment will be presented.

Quadrant anode image sensor

NASA Technical Reports Server (NTRS)

Lampton, M.; Malina, R. F.

1976-01-01

A position-sensitive event-counting electronic readout system for microchannel plates (MCPs) is described that offers the advantages of high spatial resolution and fast time resolution. The technique relies upon a four-quadrant electron-collecting anode located behind the output face of the microchannel plate, so that the electron cloud from each detected event is partly intercepted by each of the four quadrants. The relative amounts of charge collected by each quadrant depend on event position, permitting each event to be localized with two ratio circuits. A prototype quadrant anode system for ion, electron, and extreme ultraviolet imaging is described. The spatial resolution achieved, about 10 microns, allows individual MCP channels to be distinguished.

Extraction of UMLS® Concepts Using Apache cTAKES™ for German Language.

PubMed

Becker, Matthias; Böckmann, Britta

2016-01-01

Automatic information extraction of medical concepts and classification with semantic standards from medical reports is useful for standardization and for clinical research. This paper presents an approach for an UMLS concept extraction with a customized natural language processing pipeline for German clinical notes using Apache cTAKES. The objectives are, to test the natural language processing tool for German language if it is suitable to identify UMLS concepts and map these with SNOMED-CT. The German UMLS database and German OpenNLP models extended the natural language processing pipeline, so the pipeline can normalize to domain ontologies such as SNOMED-CT using the German concepts. For testing, the ShARe/CLEF eHealth 2013 training dataset translated into German was used. The implemented algorithms are tested with a set of 199 German reports, obtaining a result of average 0.36 F1 measure without German stemming, pre- and post-processing of the reports.

[German influences on Romanian medical terminology].

PubMed

Răcilă, R G; Răileanu, Irena; Rusu, V

2008-01-01

The medical terminology plays a key part both in the study of medicine as well as in its practice. Moreover, understanding the medical terms is important not only for the doctor but also for the patients who want to learn more about their condition. For these reasons we believe that the study of medical terminology is one of great interest. The aim of our paper was to evaluate the German linguistic and medical influences on the evolution of the Romanian medical terminology. Since the Romanian-German cultural contacts date back to the 12th century we had reasons to believe that the number of German medical words in Romanian would be significant. To our surprise, the Romanian language has very few German words and even less medical terms of German origin. However, when we searched the list of diseases coined after famous medical personalities, we found out that 26 % of them bore the names of German doctors and scientists. Taken together this proves that the German medical school played an important role on the evolution of Romanian medicine despite the fact that the Romanian vocabulary was slightly influenced by the German language. We explain this fact on the structural differences between the Romanian and German languages, which make it hard for German loans to be integrated in the Romanian lexis. In conclusion we state that the German influence on the Romanian medical terminology is weak despite the important contribution of the German medical school to the development of medical education and healthcare in Romania. Key

Work stress is associated with diabetes and prediabetes: cross-sectional results from the MIPH Industrial Cohort Studies.

PubMed

Li, Jian; Jarczok, Marc N; Loerbroks, Adrian; Schöllgen, Ina; Siegrist, Johannes; Bosch, Jos A; Wilson, Mark G; Mauss, Daniel; Fischer, Joachim E

2013-12-01

Diabetes is rapidly rising globally, and the relation of psychosocial stress in workplace to diabetes and prediabetes is not well investigated. The aim of the study was to examine the association of work stress with diabetes and prediabetes in a sample of German industrial workers. In this cross-sectional survey of an occupational cohort (n = 2,674, 77 % male), work stress was measured by the Effort-Reward Imbalance (ERI) Questionnaire. Diabetic status, i.e., diabetes and prediabetes, were diagnosed by glycated hemoglobin A1c criterion or fasting plasma glucose criterion supplemented by self-reports. The overall prevalence rates of diabetes and prediabetes were 3.5 and 42.2 %, respectively. Using ordinal logistic regression with adjustment for potential confounding factors, high ERI at work was associated with diabetes-related ordinal variable (odds ratio [OR], 1.27; 95 % confidence interval [95 % CI], 1.02-1.58) and prediabetes-related ordinal variable (OR, 1.26; 95 % CI, 1.01-1.58) in men, whereas the associations in women were somewhat less pronounced and did not reach statistical significance. The findings indicate that work stress in terms of ERI is associated with diabetes and prediabetes in German industrial male workers. If supported by prospective evidence, results point to a new approach towards primary prevention of diabetes.

Business German: The Use of Simulations in a Total Immersion German Business Class.

ERIC Educational Resources Information Center

Weber, Ellen

At Concordia College's Institute of German Studies (Minnesota), an immersion program, a 1-month course entitled "German in the Business World" concentrates on development of written and oral communication skills needed in firms dealing with German-speakers. As part of its emphasis on banking, insurance, and business, the course includes…

USA: German in the Changing Landscape of Postsecondary Education

ERIC Educational Resources Information Center

Tatlock, Lynne

2010-01-01

This article identifies recent indicators of the state of German Studies in the United States with special attention to postsecondary enrollments in German. It additionally reviews challenges to the postsecondary teaching of German as they manifest themselves both locally and nationally, including the positioning of German Studies in the life of…

African Americans Who Teach German Language and Culture.

ERIC Educational Resources Information Center

Fikes, Robert Jr.

2001-01-01

A large number of black scholars have pursued advanced degrees in the German language, history, and culture. Describes the history of African American interest in the German language and culture, highlighting various black scholars who have studied German over the years. Presents data on African Americans in German graduate programs and examines…

Crossing the Lexicon: Anglicisms in the German Hip Hop Community

ERIC Educational Resources Information Center

Garley, Matthew E.

2012-01-01

The influence of English on German has been an ongoing subject of intense popular and academic interest in the German sphere. In order to better understand this language contact situation, this research project investigates anglicisms--instances of English language material in a German language context--in the German hip hop community, where the…

Cost evaluation of cardiovascular magnetic resonance versus coronary angiography for the diagnostic work-up of coronary artery disease: application of the European Cardiovascular Magnetic Resonance registry data to the German, United Kingdom, Swiss, and United States health care systems.

PubMed

Moschetti, Karine; Muzzarelli, Stefano; Pinget, Christophe; Wagner, Anja; Pilz, Günther; Wasserfallen, Jean-Blaise; Schulz-Menger, Jeanette; Nothnagel, Detle; Dill, Torsten; Frank, Herbert; Lombardi, Massimo; Bruder, Oliver; Mahrholdt, Heiko; Schwitter, Jürg

2012-06-14

Cardiovascular magnetic resonance (CMR) has favorable characteristics for diagnostic evaluation and risk stratification of patients with known or suspected CAD. CMR utilization in CAD detection is growing fast. However, data on its cost-effectiveness are scarce. The goal of this study is to compare the costs of two strategies for detection of significant coronary artery stenoses in patients with suspected coronary artery disease (CAD): 1) Performing CMR first to assess myocardial ischemia and/or infarct scar before referring positive patients (defined as presence of ischemia and/or infarct scar to coronary angiography (CXA) versus 2) a hypothetical CXA performed in all patients as a single test to detect CAD. A subgroup of the European CMR pilot registry was used including 2,717 consecutive patients who underwent stress-CMR. From these patients, 21% were positive for CAD (ischemia and/or infarct scar), 73% negative, and 6% uncertain and underwent additional testing. The diagnostic costs were evaluated using invoicing costs of each test performed. Costs analysis was performed from a health care payer perspective in German, United Kingdom, Swiss, and United States health care settings. In the public sectors of the German, United Kingdom, and Swiss health care systems, cost savings from the CMR-driven strategy were 50%, 25% and 23%, respectively, versus outpatient CXA. If CXA was carried out as an inpatient procedure, cost savings were 46%, 50% and 48%, respectively. In the United States context, cost savings were 51% when compared with inpatient CXA, but higher for CMR by 8% versus outpatient CXA. This analysis suggests that from an economic perspective, the use of CMR should be encouraged as a management option for patients with suspected CAD.

Decommissioning of German Nuclear Research Facilities under the Governance of the Federal Ministry of Education and Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weigl, M.

2008-07-01

Since the announcement of the first nuclear program in 1956, nuclear R and D in Germany has been supported by the Federal Government under four nuclear programs and later on under more general energy R and D programs. The original goal was to help German industry to achieve safe, low-cost generation of energy and self-sufficiency in the various branches of nuclear technology, including the fast breeder reactor and the fuel cycle. Several national research centers were established to host or operate experimental and demonstration plants. These are mainly located at the sites of the national research centers at Juelich andmore » Karlsruhe. In the meantime, all these facilities were shut down and most of them are now in a state of decommissioning and dismantling (D and D). Meanwhile, Germany is one of the leading countries in the world in the field of D and D. Two big demonstration plants, the Niederaichbach Nuclear Power Plant (KKN) a heavy-water cooled pressure tube reactor with carbon-dioxide cooling and the Karlstein Superheated Steam Reactor (HDR) a boiling light water reactor with a thermal power of 100 MW, are totally dismantled and 'green field' is reached. For two other projects the return to 'green field' sites will be reached by the end of this decade. These are the dismantling of the Multi-Purpose Research Reactor (MZFR) and the Compact Sodium Cooled Reactor (KNK) both located at the Forschungszentrum Karlsruhe. Within these projects a lot of new solutions und innovative techniques were tested, which were developed at German universities and in small and medium sized companies mostly funded by the Federal Ministry of Education and Research (BMBF). For example, high performance underwater cutting technologies like plasma arc cutting and contact arc metal cutting. (authors)« less

How robust is the IAT? Measuring and manipulating implicit attitudes of East- and West-Germans.

PubMed

Kühnen, U; Schiessl, M; Bauer, N; Paulig, N; Pöhlmann, C; Schmidthals, K

2001-01-01

We investigated consequences of priming East-West-German related self-knowledge for the strength of implicit, ingroup-directed positive evaluations among East- and West-Germans. Based on previous studies we predicted opposite effects of self-knowledge priming for East- and West-Germans. Since in general the East-German stereotype is regarded as more negative than the West-German one, bringing to mind East-West-related self-knowledge (relative to neutral priming) was expected to attenuate ingroup favoritism for East-Germans, but to increase it for West-Germans. After having fulfilled the priming tasks, participants worked on an IAT-version in which the to be classified stimuli were East- or West-German city names (dimension 1) and positive or negative adjectives (dimension 2). Results of Experiment 1 showed (a) that East- and West-German students implicitly evaluated their ingroups as more positive than the outgroups and (b) confirmed the predictions of the priming influence. Experiment 2 replicated these findings with more representative samples from East- and West-Germany. The results are discussed with regard to underlying processes of implicit attitudes in intergroup contexts.

Feasibility study of a clinical decision support system for the management of multimorbid seniors in primary care: study protocol.

PubMed

Weltermann, Birgitta; Kersting, Christine

2016-01-01

Care for seniors is complex because patients often have more than one disease, one medication, and one physician. It is a key challenge for primary care physicians to structure the various aspects of each patient's care, to integrate each patient's preferences, and to maintain a long-term overview. This article describes the design for the development and feasibility testing of the clinical decision support system (CDSS) eCare*Seniors© which is electronic health record (EHR)-based allowing for a long-term, comprehensive, evidence-based, and patient preference-oriented management of multimorbid seniors. This mixed-methods study is designed in three steps. First, focus groups and practice observations will be conducted to develop criteria for software design from a physicians' and practice assistants' perspective. Second, based on these criteria, a CDSS prototype will be developed. Third, the prototype's feasibility will be tested by five primary care practices in the care of 30 multimorbid seniors. Primary outcome is the usability of the software measured by the validated system usability scale (SUS) after 3 months. Secondary outcomes are the (a) willingness to routinely use the CDSS, (b) degree of utilization of the CDSS, (c) acceptance of the CDSS, (d) willingness of the physicians to purchase the CDSS, and (e) willingness of the practice assistants to use the CDSS in the long term. These outcomes will be measured using semi-structured interviews and software usage data. If the SUS score reaches ≥70 %, feasibility testing will be judged successful. Otherwise, the CDSS prototype will be refined according to the users' needs and retested by the physicians and practice assistants until it is fully adapted to their requirements and reaches a usability score ≥70 %. The study will support the development of a CDSS which is primary care-defined, user-friendly, easy-to-comprehend, workflow-oriented, and comprehensive. The software will assist physicians and practices in their long-term, individualized care for multimorbid seniors. German Clinical Trials Register, DRKS00008777.

Parametric study of injection rates with solenoid injectors in an injection quantity and rate measuring device

DOE PAGES

Busch, Stephen; Miles, Paul C.

2015-03-31

A Moehwald HDA (HDA is a German acronym: Hydraulischer Druckanstieg: hydraulic pressure increase) injection quantity and rate measuring unit is used to investigate injection rates obtained with a fast-acting, preproduction diesel solenoid injector. Experimental parametric variations are performed to determine their impact on measured injection rate traces. A pilot–main injection strategy is investigated for various dwell times; these preproduction injectors can operate with very short dwell times with distinct pilot and main injection events. Dwell influences the main injection rate shape. Furthermore, a comparison between a diesel-like fuel and a gasoline-like fuel shows that injection rates are comparable for amore » single injection but dramatically different for multiple injections with short dwells.« less

[The boycott against German scientists and the German language after World War I].

PubMed

Reinbothe, R

2013-12-01

After the First World War, the Allied academies of sciences staged a boycott against German scientists and the German language. The objective of the boycott was to prevent the re-establishment of the prewar dominance of German scientists, the German language and German publications in the area of international scientific cooperation. Therefore the Allies excluded German scientists and the German language from international associations, congresses and publications, while they created new international scientific organizations under their leadership. Medical associations and congresses were also affected, e. g. congresses on surgery, ophthalmology and tuberculosis. Allied physicians replaced the "International Anti-Tuberculosis Association" founded in Berlin in 1902 with the "Union Internationale contre la Tuberculose"/"International Union against Tuberculosis", founded in Paris in 1920. Only French and English were used as the official languages of the new scientific organizations, just as in the League of Nations. The boycott was based on the fact that the German scientists had denied German war guilt and war crimes and glorified German militarism in a manifesto "To The Civilized World!" in 1914. The boycott first started in 1919 and had to be abolished in 1926, when Germany became a member of the League of Nations. Many German and foreign physicians as well as other scientists protested against the boycott. Some German scientists and institutions even staged a counter-boycott impeding the resumption of international collaboration. The boycott entailed an enduring decline of German as an international scientific language. After the Second World War scientists of the victorious Western Powers implemented a complete reorganization of the international scientific arena, based on the same organizational structures and language restrictions they had built up in 1919/1920. At the same time scientists from the U.S.A. staged an active language and publication policy, in order to establish the dominance of English in the international scientific arena. © Georg Thieme Verlag KG Stuttgart · New York.

Cost-effectiveness analysis of prognostic gene expression signature-based stratification of early breast cancer patients.

PubMed

Blank, Patricia R; Filipits, Martin; Dubsky, Peter; Gutzwiller, Florian; Lux, Michael P; Brase, Jan C; Weber, Karsten E; Rudas, Margaretha; Greil, Richard; Loibl, Sibylle; Szucs, Thomas D; Kronenwett, Ralf; Schwenkglenks, Matthias; Gnant, Michael

2015-02-01

The individual risk of recurrence in hormone receptor-positive primary breast cancer patients determines whether adjuvant endocrine therapy should be combined with chemotherapy. Clinicopathological parameters and molecular tests such as EndoPredict(®) (EPclin) can support decision making in patients with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative cancer. Using a life-long Markov state transition model, we determined the health economic impact and incremental cost effectiveness of EPclin-based risk stratification in combination with clinical guidelines [German-S3, National Comprehensive Cancer Center Network (NCCN), and St. Gallen] to decide on chemotherapy use. Information on overall and metastasis-free survival came from Austrian Breast & Colorectal Cancer Study Group clinical trials 6/8 (n = 1,619) and published literature. Effectiveness was assessed as quality-adjusted life-years (QALYs). Costs (2010) were assessed from a German third-party payer perspective. Lifetime costs per patient ranged from 28,268 (St.Gallen and EPclin) to 33,756 (NCCN). Due to an imperfect prognostic value and differences in chemotherapy use, strategies achieved between 13.165 QALYs (NCCN) and 13.173 QALYs (EPclin alone) per patient. Using German-S3 as reference, three strategies showed dominant results (St. Gallen and EPclin, German-S3 and EPclin, EPclin alone). Compared to German-S3, the addition of EPclin saved 3,388 and gained 0.002 QALYs per patient. Combining guidelines with EPclin remained preferable in sensitivity analysis. Our study suggests that molecular markers can be sensibly combined with clinical guidelines to determine the risk profile of adjuvant breast cancer patients. Compared with the current German best practice (German-S3), combinations of EPclin with the St. Gallen, German-S3 or NCCN guideline and EPclin alone were dominant from the perspective of the German healthcare system.

DOE Office of Scientific and Technical Information (OSTI.GOV)

St James, S; Argento, D; DeWitt, D

Purpose: Fast neutron therapy is offered at the University of Washington Medical Center for treatment of selected cancers. The hardware and control systems of the UW Clinical Neutron Therapy System are undergoing upgrades to enable delivery of IMNT. To clinically implement IMNT, dose verification tools need to be developed. We propose a portal imaging system that relies on the creation of positron emitting isotopes ({sup 11}C and {sup 15}O) through (n, 2n) reactions with a PMMA plate placed below the patient. After field delivery, the plate is retrieved from the vault and imaged using a reader that detects the annihilationmore » photons. The pattern of activity produced in the plate provides information to reconstruct the neutron fluence map that can be compared to fluence maps from Monte Carlo (MCNP) simulations to verify treatment delivery. We have previously performed Monte Carlo simulations of the portal imaging system (GATE simulations) and the beam line (MCNP simulations). In this work, initial measurements using a prototype system are presented. Methods: Custom electronics were developed for BGO detectors read out with photomultiplier tubes (previous generation PET detectors from a CTI ECAT 953 scanner). Two detectors were placed in coincidence, with a detector separation of 2 cm. Custom software was developed to create the crystal look up tables and perform a limited angle planar reconstruction with a stochastic normalization. To test the initial capabilities of the system, PMMA squares were irradiated with neutrons at a depth of 1.5 cm and read out using the prototype system. Doses ranging from 10–200 cGy were delivered. Results: Using the prototype system, dose differences in the therapeutic range could be determined. Conclusion: The prototype portal imaging system is capable of detecting neutron doses as low as 10–50 cGy and shows great promise as a patient QA tool for IMNT.« less

Language-related values, reading amount, and reading comprehension in students with migration backgrounds.

PubMed

El-Khechen, Wahiba; Ferdinand, Hanna D; Steinmayr, Ricarda; McElvany, Nele

2016-06-01

Although various studies on general language performance have investigated determinants of students' reading comprehension (e.g., reading amount), they have paid insufficient attention to how students perceive parental values influence their language-related values and behaviour - and, as a consequence, their performance. This is particularly the case for bilingual students with a migration background. The present study aims to examine the impact of how students perceive parental values regarding German (attainment, utility, and cost), students' (utility) value of German/Turkish, and students' reading amount in German/Turkish on German reading comprehension. A total of 118 Grade 4 students in Germany with Turkish as their family language. Reading comprehension was measured with a 15-item standardized test. Whereas students' reading amount (German/Turkish) was assessed through students' self-reports on three questions, students' utility value (German/Turkish) and perceived parental values regarding German (attainment, utility, and cost) were each measured with two items. Results of path modelling supported the hypotheses that students' utility value regarding German and their reading amount in German would positively predict their German reading comprehension, whereas their utility value regarding Turkish and their reading amount in Turkish would negatively predict their German reading comprehension. Data also confirmed a direct effect of the negatively perceived parental cost value of German on German reading comprehension. The new evidence is of practical relevance for teachers, educational scientists, and psychologists who are striving to improve the educational outcomes of bilingual students. Further research needs and the significance of the results for educational practice and home environment are discussed. © 2015 The British Psychological Society.

Friends Indeed? Coalition Burden Sharing and the War In Iraq. Volume 1

DTIC Science & Technology

2008-08-05

Malici, "Germans as Venutians: The Culture of German Foreign Policy Behavior." 36 Joachim Krause , "The Role of the Bundestag in German Foreign Policy...Hampshire ; New York: Palgrave, 2001), 159. 37 Erb, German Foreign Policy: Navigating a New Era, 191. 38 Krause , "The Role of the Bundestag in German...policy expert Wolfgang Schaeuble accused the German government of “creating a bogey” and weakening the United Nations in the Iraq debate for its

Testing Language, Testing Ethnicity? Policies and Practices Surrounding the Ethnic German "Aussiedler"

ERIC Educational Resources Information Center

Schupbach, Doris

2009-01-01

"Aussiedler" are ethnic Germans from the former Soviet Union and other Eastern European countries who are granted the right to resettle in the Federal Republic of Germany (FRG) if they can provide evidence of German ancestry, attachment to the German language and culture, and ongoing assertion of German ethnicity. This article outlines…

Creating Germans Abroad: White Education and the Colonial Condition in German Southwest Africa, 1894-1914

ERIC Educational Resources Information Center

Walther, Daniel Joseph

2013-01-01

From the perspective of German colonial supporters and authorities, appropriate white education in the settler colony of Southwest Africa (SWA) was essential for maintaining German hegemony in the territory. In order to reach this objective, the German colonial administration in SWA, with assistance from pedagogues and institutions in Germany,…

Teaching Games for Understanding Conference Supplement from the German Sport University

ERIC Educational Resources Information Center

Research Quarterly for Exercise and Sport, 2016

2016-01-01

By bringing together the national German sports game community and an international scientific community in a joint conference, the 6th International Teaching Games for Understanding Conference (TGfU) Meets the 10th German Sports Games Symposium of the German Association of Sport Science (DVS), held July 25-27, 2016, at the German Sport University…

9. DETAIL OF BRICKWORK ON SOUTHEAST SIDE OF GERMAN VILLAGE. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. DETAIL OF BRICKWORK ON SOUTHEAST SIDE OF GERMAN VILLAGE. - Dugway Proving Ground, German-Japanese Village, German Village, South of Stark Road, in WWII Incendiary Test Area, Dugway, Tooele County, UT

8. VIEW OF SOUTHWEST END OF GERMAN VILLAGE LOOKING NORTHEAST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. VIEW OF SOUTHWEST END OF GERMAN VILLAGE LOOKING NORTHEAST. - Dugway Proving Ground, German-Japanese Village, German Village, South of Stark Road, in WWII Incendiary Test Area, Dugway, Tooele County, UT

4. VIEW OF NORTHWEST SIDE OF GERMAN VILLAGE LOOKING SOUTHEAST. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. VIEW OF NORTHWEST SIDE OF GERMAN VILLAGE LOOKING SOUTHEAST. - Dugway Proving Ground, German-Japanese Village, German Village, South of Stark Road, in WWII Incendiary Test Area, Dugway, Tooele County, UT

Full Scale Advanced Systems Testbed (FAST): Capabilities and Recent Flight Research

NASA Technical Reports Server (NTRS)

Miller, Christopher

2014-01-01

At the NASA Armstrong Flight Research Center research is being conducted into flight control technologies that will enable the next generation of air and space vehicles. The Full Scale Advanced Systems Testbed (FAST) aircraft provides a laboratory for flight exploration of these technologies. In recent years novel but simple adaptive architectures for aircraft and rockets have been researched along with control technologies for improving aircraft fuel efficiency and control structural interaction. This presentation outlines the FAST capabilities and provides a snapshot of the research accomplishments to date. Flight experimentation allows a researcher to substantiate or invalidate their assumptions and intuition about a new technology or innovative approach Data early in a development cycle is invaluable for determining which technology barriers are real and which ones are imagined Data for a technology at a low TRL can be used to steer and focus the exploration and fuel rapid advances based on real world lessons learned It is important to identify technologies that are mature enough to benefit from flight research data and not be tempted to wait until we have solved all the potential issues prior to getting some data Sometimes a stagnated technology just needs a little real world data to get it going One trick to getting data for low TRL technologies is finding an environment where it is okay to take risks, where occasional failure is an expected outcome Learning how things fail is often as valuable as showing that they work FAST has been architected to facilitate this type of testing for control system technologies, specifically novel algorithms and sensors Rapid prototyping with a quick turnaround in a fly-fix-fly paradigm Sometimes it's easier and cheaper to just go fly it than to analyze the problem to death The goal is to find and test control technologies that would benefit from flight data and find solutions to the real barriers to innovation. The FAST vehicle is a flexible laboratory for nascent technologies that would benefit from early life cycle flight research data It provides a robust and safe environment where innovative techniques can be explored in a fly-fix-fly rapid prototyping paradigm IRAC Simple adaptive control technologies can provide real benefits without undo complexity Adverse pilot/adaptive system interactions can be mitigated and tools have been developed to evaluate those interactions ICP Substantial fuel savings can be achieved over a broad range of vehicles and configurations with intelligent control solutions LVAC The AAC design is robust and effective for the SLS mission, and promises to provide benefits to other platforms as well OCLA Hopefully will show that structural feedback can be seamlessly integrated with performance and stability objectives All of these control technologies have been implemented into the same baseline control law and could be combined into one control solution that answers many pressing questions for modern vehicle configurations

Cross-Linguistic Differences in Prosodic Cues to Syntactic Disambiguation in German and English

ERIC Educational Resources Information Center

O'Brien, Mary Grantham; Jackson, Carrie N.; Gardner, Christine E.

2014-01-01

This study examined whether late-learning English-German second language (L2) learners and late-learning German-English L2 learners use prosodic cues to disambiguate temporarily ambiguous first language and L2 sentences during speech production. Experiments 1a and 1b showed that English-German L2 learners and German-English L2 learners used a…

Gender differences in depression scores of Iranian and german medical students.

PubMed

Ahmadi, Jamshid; Ahmadi, Nahid; Soltani, Fereshteh; Bayat, Fatemeh

2014-01-01

The aim was to evaluate gender differences in depression scores of Iranian and German medical students. Two hundred Iranian medical students (100 men and 100 women) and 200 German medical students (100 men and 100 women) were selected randomly and completed the English form of the self-rating Beck Depression Inventory (BDI). Analysis gave a mean rating of 10.7 ± 6.6 for Iranian men and 10.9 ± 7.81 for Iranian women (NS). Also, 5 ± 4.9 for German men and 5.6 ± 5.0 for German women (NS). On Item 2, which asked whether the person was pessimistic 33% of Iranian men and 30% of Iranian women indicated that they were pessimistic (NS). Also, 21% of German men and 20% of German women indicated that they were pessimistic (NS). On Item 9, which asked about suicidal tendencies, 9% of Iranian men and 13% of Iranian women reported as having suicidal tendencies (NS). Also, 13% of German men and 21% of German women reported as having self-harming thoughts (NS). The present study showed no gender differences in Iranian and German medical students' scores on the BDI.

Healthcare Hackathons Provide Educational and Innovation Opportunities: A Case Study and Best Practice Recommendations.

PubMed

Silver, Julie K; Binder, David S; Zubcevik, Nevena; Zafonte, Ross D

2016-07-01

Physicians and other healthcare professionals are often the end users of medical innovation; however, they are rarely involved in the beginning design stages. This often results in ineffective healthcare solutions with poor adoption rates. At the early design stage, innovation would benefit from input from healthcare professionals. This report describes the first-ever rehabilitation hackathon-an interdisciplinary and competitive team event aimed at accelerating and improving healthcare solutions and providing an educational experience for participants. Hackathons are gaining traction as a way to accelerate innovation by bringing together a diverse group of interdisciplinary professionals from different industries who work collaboratively in teams and learn from each other, focus on a specific problem ("pain point"), develop a solution using design thinking techniques, pitch the solution to participants, gather fast feedback and quickly alter the prototype design ("pivoting"). 102 hackers including 19 (18.6 %) physicians and other professionals participated, and over the course of 2 days worked in teams, pitched ideas and developed design prototypes. Three awards were given for prototypes that may improve function in persons with disabilities. 43 hackers were women (42.2 %) and 59 men (57.8 %); they ranged in age from 16 to 79 years old; and, of the 75 hackers who reported their age, 63 (84 %) were less than 40 years old and 12 (16 %) were 40 years or older. This report contributes to the emerging literature on healthcare hackathons as a means of providing interdisciplinary education and training and supporting innovation.

Development, Evaluation, and Integration of a Quantitative Reverse-Transcription Polymerase Chain Reaction Diagnostic Test for Ebola Virus on a Molecular Diagnostics Platform

PubMed Central

Cnops, Lieselotte; Van den Eede, Peter; Pettitt, James; Heyndrickx, Leo; De Smet, Birgit; Coppens, Sandra; Andries, Ilse; Pattery, Theresa; Van Hove, Luc; Meersseman, Geert; Van Den Herrewegen, Sari; Vergauwe, Nicolas; Thijs, Rein; Jahrling, Peter B.; Nauwelaers, David; Ariën, Kevin K.

2016-01-01

Background. The 2013–2016 Ebola epidemic in West Africa resulted in accelerated development of rapid diagnostic tests for emergency outbreak preparedness. We describe the development and evaluation of the Idylla™ prototype Ebola virus test, a fully automated sample-to-result molecular diagnostic test for rapid detection of Zaire ebolavirus (EBOV) and Sudan ebolavirus (SUDV). Methods. The Idylla™ prototype Ebola virus test can simultaneously detect EBOV and SUDV in 200 µL of whole blood. The sample is directly added to a disposable cartridge containing all reagents for sample preparation, RNA extraction, and amplification by reverse-transcription polymerase chain reaction analysis. The performance was evaluated with a variety of sample types, including synthetic constructs and whole blood samples from healthy volunteers spiked with viral RNA, inactivated virus, and infectious virus. Results. The 95% limits of detection for EBOV and SUDV were 465 plaque-forming units (PFU)/mL (1010 copies/mL) and 324 PFU/mL (8204 copies/mL), respectively. In silico and in vitro analyses demonstrated 100% correct reactivity for EBOV and SUDV and no cross-reactivity with relevant pathogens. The diagnostic sensitivity was 97.4% (for EBOV) and 91.7% (for SUDV), the specificity was 100%, and the diagnostic accuracy was 95.9%. Conclusions. The Idylla™ prototype Ebola virus test is a fast, safe, easy-to-use, and near-patient test that meets the performance criteria to detect EBOV in patients with suspected Ebola. PMID:27247341

Urinary lithogenesis risk tests: comparison of a commercial kit and a laboratory prototype test.

PubMed

Grases, Félix; Costa-Bauzá, Antonia; Prieto, Rafel M; Arrabal, Miguel; De Haro, Tomás; Lancina, Juan A; Barbuzano, Carmen; Colom, Sergi; Riera, Joaquín; Perelló, Joan; Isern, Bernat; Sanchis, Pilar; Conte, Antonio; Barragan, Fernando; Gomila, Isabel

2011-11-01

Renal stone formation is a multifactorial process depending in part on urine composition. Other parameters relate to structural or pathological features of the kidney. To date, routine laboratory estimation of urolithiasis risk has been based on determination of urinary composition. This process requires collection of at least two 24 h urine samples, which is tedious for patients. The most important feature of urinary lithogenic risk is the balance between various urinary parameters, although unknown factors may be involved. The objective of this study was to compare data obtained using a commercial kit with those of a laboratory prototype, using a multicentre approach, to validate the utility of these methods in routine clinical practice. A simple new commercial test (NefroPlus®; Sarstedt AG & Co., Nümbrecht, Germany) evaluating the capacity of urine to crystallize calcium salts, and thus permitting detection of patients at risk for stone development, was compared with a prototype test previously described by this group. Urine of 64 volunteers produced during the night was used in these comparisons. The commercial test was also used to evaluate urine samples of 83 subjects in one of three hospitals. Both methods were essentially in complete agreement (98%) with respect to test results. The multicentre data were: sensitivity 94.7%; specificity 76.9%; positive predictive value (lithogenic urine) 90.0%; negative predictive value (non-lithogenic urine) 87.0%; test efficacy 89.2%. The new commercial NefroPlus test offers fast and cheap evaluation of the overall risk of development of urinary calcium-containing calculi.

High frequency copolymer ultrasonic transducer array of size-effective elements

NASA Astrophysics Data System (ADS)

Decharat, Adit; Wagle, Sanat; Habib, Anowarul; Jacobsen, Svein; Melandsø, Frank

2018-02-01

A layer-by-layer deposition method for producing dual-layer ultrasonic transducers from piezoelectric copolymers has been developed. The method uses a combination of customized and standard processing to obtain 2D array transducers with electrical connection of the individual elements routed directly to the rear of the substrate. A numerical model was implemented to study basic parameters effecting the transducer characteristics. Key elements of the array were characterized and evaluated, demonstrating its viability of 2D imaging. Signal reproducibility of the prototype array was studied by characterizing the variations of the center frequency (≈42 MHz) and bandwidth (≈25 MHz) of the acoustic. Object identification was also tested and parameterized by acoustic-field beamwidth as well as proper scan step size. Simple tests to illustrate a benefit of multi-element scan on lowering the inspection time were conducted. Structural imaging of the test structure underneath multi-layered wave media (glass plate and distilled water) was also performed. The prototype presented in this work is an important step towards realizing an inexpensive, compact array of individually operated copolymer transducers that can serve in a fast/volumetric high frequency (HF) ultrasonic scanning platform.

Timing resolution studies of the optical part of the AFP Time-of-flight detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chytka, L.; Avoni, G.; Brandt, A.

We present results of the timing performance studies of the optical part and front-end electronics of the time-of-flight subdetector prototype for the ATLAS Forward Proton (AFP) detector obtained during the test campaigns at the CERN-SPS test-beam facility (120 GeV π + particles) in July 2016 and October 2016. The time-of-flight (ToF) detector in conjunction with a 3D silicon pixel tracker will tag and measure protons originating in central exclusive interactions p + p → p + X + p, where the two outgoing protons are scattered in the very forward directions. The ToF is required to reduce so-called pileup backgroundsmore » that arise from multiple proton interactions in the same bunch crossing at high luminosity. The background can fake the signal of interest, and the extra rejection from the ToF allows the proton tagger to operate at the high luminosity required for the measurement of the processes. The prototype detector uses fused silica bars emitting Cherenkov radiation as a relativistic particle passes through them. The emitted Cherenkov photons are detected by a multi-anode micro-channel plate photomultiplier tube (MCP-PMT) and processed by fast electronics.« less

Inexpensive, rapid fabrication of polymer-film microfluidic autoregulatory valve for disposable microfluidics.

PubMed

Zhang, Xinjie; Zhu, Zhixian; Ni, Zhonghua; Xiang, Nan; Yi, Hong

2017-06-01

This work presents the fabrication of a microfluidic autoregulatory valve which is composed of several layers of thin polymer films (i.e., polyvinyl chloride (PVC), polyethylene terephthalate (PET) double-sided tape, and polydimethylsiloxane (PDMS)). Briefly, pulsed UV laser is employed to cut the microstructures of through grooves or holes in the thermoplastic polymer films, and then the polymer-film valves are precisely assembled through laminating the PDMS membranes to the thermoplastic polymer films through the roll-lamination method. The effective bonding between the PVC film and the PDMS membrane is realized using the planar seal method, and the valve is sandwiched and compressed by a home-made housing to achieve the good seal effect. Then, the flow performances of the prototype valve are examined, and constant flow autoregulation is realized under the static or dynamic test pressures. The long-term response of the valve is also studied and minimum flow-rate decrements are found over a long actuation time. The fabrication method proposed in this work is successful for the low-cost and fast prototyping of the polymer-film valve. We believe our method will also be broadly applicable for fabrication of other low-cost and disposable polymer-film microfluidic devices.

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology

PubMed Central

Gokaltun, Aslihan; Yarmush, Martin L.; Asatekin, Ayse; Usta, O. Berk

2017-01-01

In the last decade microfabrication processes including rapid prototyping techniques have advanced rapidly and achieved a fairly mature stage. These advances have encouraged and enabled the use of microfluidic devices by a wider range of users with applications in biological separations and cell and organoid cultures. Accordingly, a significant current challenge in the field is controlling biomolecular interactions at interfaces and the development of novel biomaterials to satisfy the unique needs of the biomedical applications. Poly(dimethylsiloxane) (PDMS) is one of the most widely used materials in the fabrication of microfluidic devices. The popularity of this material is the result of its low cost, simple fabrication allowing rapid prototyping, high optical transparency, and gas permeability. However, a major drawback of PDMS is its hydrophobicity and fast hydrophobic recovery after surface hydrophilization. This results in significant nonspecific adsorption of proteins as well as small hydrophobic molecules such as therapeutic drugs limiting the utility of PDMS in biomedical microfluidic circuitry. Accordingly, here, we focus on recent advances in surface molecular treatments to prevent fouling of PDMS surfaces towards improving its utility and expanding its use cases in biomedical applications. PMID:28695160

Nanosatellite optical downlink experiment: design, simulation, and prototyping

NASA Astrophysics Data System (ADS)

Clements, Emily; Aniceto, Raichelle; Barnes, Derek; Caplan, David; Clark, James; Portillo, Iñigo del; Haughwout, Christian; Khatsenko, Maxim; Kingsbury, Ryan; Lee, Myron; Morgan, Rachel; Twichell, Jonathan; Riesing, Kathleen; Yoon, Hyosang; Ziegler, Caleb; Cahoy, Kerri

2016-11-01

The nanosatellite optical downlink experiment (NODE) implements a free-space optical communications (lasercom) capability on a CubeSat platform that can support low earth orbit (LEO) to ground downlink rates>10 Mbps. A primary goal of NODE is to leverage commercially available technologies to provide a scalable and cost-effective alternative to radio-frequency-based communications. The NODE transmitter uses a 200-mW 1550-nm master-oscillator power-amplifier design using power-efficient M-ary pulse position modulation. To facilitate pointing the 0.12-deg downlink beam, NODE augments spacecraft body pointing with a microelectromechanical fast steering mirror (FSM) and uses an 850-nm uplink beacon to an onboard CCD camera. The 30-cm aperture ground telescope uses an infrared camera and FSM for tracking to an avalanche photodiode detector-based receiver. Here, we describe our approach to transition prototype transmitter and receiver designs to a full end-to-end CubeSat-scale system. This includes link budget refinement, drive electronics miniaturization, packaging reduction, improvements to pointing and attitude estimation, implementation of modulation, coding, and interleaving, and ground station receiver design. We capture trades and technology development needs and outline plans for integrated system ground testing.

The Gigatracker: An ultra-fast and low-mass silicon pixel detector for the NA62 experiment

NASA Astrophysics Data System (ADS)

Fiorini, M.; Carassiti, V.; Ceccucci, A.; Cortina, E.; Cotta Ramusino, A.; Dellacasa, G.; Garbolino, S.; Jarron, P.; Kaplon, J.; Kluge, A.; Mapelli, A.; Marchetto, F.; Martin, E.; Martoiu, S.; Mazza, G.; Morel, M.; Noy, M.; Nuessle, G.; Petrucci, F.; Riedler, P.; Aglieri Rinella, G.; Rivetti, A.; Tiuraniemi, S.

2011-02-01

The Gigatracker is a hybrid silicon pixel detector developed to track the highly intense NA62 hadron beam with a time resolution of 150 ps (rms). The beam spectrometer of the experiment is composed of three Gigatracker stations installed in vacuum in order to precisely measure momentum, time and direction of every traversing particle. Precise tracking demands a very low mass of the detector assembly ( <0.5% X0 per station) in order to limit multiple scattering and beam hadronic interactions. The high rate and especially the high timing precision requirements are very demanding: two R&D options are ongoing and the corresponding prototype read-out chips have been recently designed and produced in 0.13 μm CMOS technology. One solution makes use of a constant fraction discriminator and on-pixel analogue-based time-to-digital-converter (TDC); the other comprises a delay-locked loop based TDC placed at the end of each pixel column and a time-over-threshold discriminator with time-walk correction technique. The current status of the R&D program is overviewed and results from the prototype read-out chips test are presented.

Design and Field Test of a WSN Platform Prototype for Long-Term Environmental Monitoring

PubMed Central

Lazarescu, Mihai T.

2015-01-01

Long-term wildfire monitoring using distributed in situ temperature sensors is an accurate, yet demanding environmental monitoring application, which requires long-life, low-maintenance, low-cost sensors and a simple, fast, error-proof deployment procedure. We present in this paper the most important design considerations and optimizations of all elements of a low-cost WSN platform prototype for long-term, low-maintenance pervasive wildfire monitoring, its preparation for a nearly three-month field test, the analysis of the causes of failure during the test and the lessons learned for platform improvement. The main components of the total cost of the platform (nodes, deployment and maintenance) are carefully analyzed and optimized for this application. The gateways are designed to operate with resources that are generally used for sensor nodes, while the requirements and cost of the sensor nodes are significantly lower. We define and test in simulation and in the field experiment a simple, but effective communication protocol for this application. It helps to lower the cost of the nodes and field deployment procedure, while extending the theoretical lifetime of the sensor nodes to over 16 years on a single 1 Ah lithium battery. PMID:25912349

Characterization studies of prototype ISOL targets for the RIA

NASA Astrophysics Data System (ADS)

Greene, John P.; Burtseva, Tatiana; Neubauer, Janelle; Nolen, Jerry A.; Villari, Antonio C. C.; Gomes, Itacil C.

2005-12-01

Targets employing refractory compounds are being developed for the rare isotope accelerator (RIA) facility to produce ion species far from stability. With the 100 kW beams proposed for the production targets, dissipation of heat becomes a challenging issue. In our two-step target design, neutrons are generated in a refractory primary target, inducing fission in the surrounding uranium carbide. The interplay of density, grain size, thermal conductivity and diffusion properties of the UC2 needs to be well understood before fabrication. Thin samples of uranium carbide were prepared for thermal conductivity measurements using an electron beam to heat the sample and an optical pyrometer to observe the thermal radiation. Release efficiencies and independent thermal analysis on these samples are being undertaken at Oak Ridge National Laboratory (ORNL). An alternate target concept for RIA, the tilted slab approach promises to be simple with fast ion release and capable of withstanding high beam intensities while providing considerable yields via spallation. A proposed small business innovative research (SBIR) project will design a prototype tilted target, exploring the materials needed for fabrication and testing at an irradiation facility to address issues of heat transfer and stresses within the target.

Back-end and interface implementation of the STS-XYTER2 prototype ASIC for the CBM experiment

NASA Astrophysics Data System (ADS)

Kasinski, K.; Szczygiel, R.; Zabolotny, W.

2016-11-01

Each front-end readout ASIC for the High-Energy Physics experiments requires robust and effective hit data streaming and control mechanism. A new STS-XYTER2 full-size prototype chip for the Silicon Tracking System and Muon Chamber detectors in the Compressed Baryonic Matter experiment at Facility for Antiproton and Ion Research (FAIR, Germany) is a 128-channel time and amplitude measuring solution for silicon microstrip and gas detectors. It operates at 250 kHit/s/channel hit rate, each hit producing 27 bits of information (5-bit amplitude, 14-bit timestamp, position and diagnostics data). The chip back-end implements fast front-end channel read-out, timestamp-wise hit sorting, and data streaming via a scalable interface implementing the dedicated protocol (STS-HCTSP) for chip control and hit transfer with data bandwidth from 9.7 MHit/s up to 47 MHit/s. It also includes multiple options for link diagnostics, failure detection, and throttling features. The back-end is designed to operate with the data acquisition architecture based on the CERN GBTx transceivers. This paper presents the details of the back-end and interface design and its implementation in the UMC 180 nm CMOS process.

Time-resolved imaging of the plasma development in a triggered vacuum switch

NASA Astrophysics Data System (ADS)

Park, Wung-Hoa; Kim, Moo-Sang; Son, Yoon-Kyoo; Frank, Klaus; Lee, Byung-Joon; Ackerman, Thilo; Iberler, Marcus

2017-12-01

Triggered vacuum switches (TVS) are particularly used in pulsed power technology as closing switches for high voltages and high charge transfer. A non-sealed-off prototype was designed with a side-on quartz window to investigate the evolution of the trigger discharge into the main discharge. The image acquisition was done with a fast CCD camera PI-MAX2 from Princeton Instruments. The CCD camera has a maximum exposure time of 2 ns. The electrode configuration of the prototype is a conventional six-rod gap type, a capacitor bank with C = 16.63 μF, which corresponds at 20 kV charging voltage to a total stored charge of 0.3 C or a total energy of 3.3 kJ. The peak current is 88 kA. According to the tremendously highly different light intensities during the trigger and main discharge, the complete discharge is split into three phases: a trigger breakdown phase, an intermediate phase and a main discharge phase. The CCD camera images of the first phase show instabilities of the trigger breakdown, in phase 2 three different discharge modes are observed. After the first current maximum the discharge behavior is reproducible.

Timing resolution studies of the optical part of the AFP Time-of-flight detector

DOE PAGES

Chytka, L.; Avoni, G.; Brandt, A.; ...

2018-04-02

We present results of the timing performance studies of the optical part and front-end electronics of the time-of-flight subdetector prototype for the ATLAS Forward Proton (AFP) detector obtained during the test campaigns at the CERN-SPS test-beam facility (120 GeV π + particles) in July 2016 and October 2016. The time-of-flight (ToF) detector in conjunction with a 3D silicon pixel tracker will tag and measure protons originating in central exclusive interactions p + p → p + X + p, where the two outgoing protons are scattered in the very forward directions. The ToF is required to reduce so-called pileup backgroundsmore » that arise from multiple proton interactions in the same bunch crossing at high luminosity. The background can fake the signal of interest, and the extra rejection from the ToF allows the proton tagger to operate at the high luminosity required for the measurement of the processes. The prototype detector uses fused silica bars emitting Cherenkov radiation as a relativistic particle passes through them. The emitted Cherenkov photons are detected by a multi-anode micro-channel plate photomultiplier tube (MCP-PMT) and processed by fast electronics.« less

Development of Torsional and Linear Piezoelectrically Driven Motors

NASA Technical Reports Server (NTRS)

Duong, Khanh; Newton, David; Garcia, Ephrahim

1996-01-01

The development of rotary and linear inchworm-motors using piezoelectric actuators is presented. The motors' design has the advantage of a macro and micro stepper motor with high load and speed. The torsional design is capable of fast angular positioning with micro level accuracy. Additionally, the rotary motor, as designed, can be used as a clutch/brake mechanism. Constructed prototype motors of both types along with their characteristics are presented. The torsional motor consists of a torsional section that provides angular displacement and torque, and two alternating clamping sections which provide the holding force. The motor relies on the principal piezoelectric coupling coefficient (d33) with no torsional elements, increasing its torque capability. The linear motor consists of a longitudinal vibrator that provides displacement and load, and two alternating clamping sections which provide the holding force. This design eliminates bending moment, tension and shear applied to the actuator elements, increase its load capability and life. Innovative flexure designs have been introduced for both motor types. Critical issues that affect the design and performance of the motors are explored and discussed. Experiments are performed demonstrating the motor prototypes based on the aforementioned design considerations.

Lithographic manufacturing of adaptive optics components

NASA Astrophysics Data System (ADS)

Scott, R. Phillip; Jean, Madison; Johnson, Lee; Gatlin, Ridley; Bronson, Ryan; Milster, Tom; Hart, Michael

2017-09-01

Adaptive optics systems and their laboratory test environments call for a number of unusual optical components. Examples include lenslet arrays, pyramids, and Kolmogorov phase screens. Because of their specialized application, the availability of these parts is generally limited, with high cost and long lead time, which can also significantly drive optical system design. These concerns can be alleviated by a fast and inexpensive method of optical fabrication. To that end, we are exploring direct-write lithographic techniques to manufacture three different custom elements. We report results from a number of prototype devices including 1, 2, and 3 wave Multiple Order Diffractive (MOD) lenslet arrays with 0.75 mm pitch and phase screens with near Kolmogorov structure functions with a Fried length r0 around 1 mm. We also discuss plans to expand our research to include a diffractive pyramid that is smaller, lighter, and more easily manufactured than glass versions presently used in pyramid wavefront sensors. We describe how these components can be produced within the limited dynamic range of the lithographic process, and with a rapid prototyping and manufacturing cycle. We discuss exploratory manufacturing methods, including replication, and potential observing techniques enabled by the ready availability of custom components.

German science and black racism--roots of the Nazi Holocaust.

PubMed

Haas, François

2008-02-01

The Nazi's cornerstone precept of "racial hygiene" gave birth to their policy of "racial cleansing" that led to the murders of millions. It was developed by German physicians and scientists in the late 19th century and is rooted in the period's Social Darwinism that placed blacks at the bottom of the racial ladder. This program was first manifested in the near-extermination of the African Herero people during the German colonial period. After WWI, the fear among the German populace that occupying African troops and their Afro-German children would lead to "bastardization" of the German people formed a unifying racial principle that the Nazis exploited. They extended this mind-set to a variety of "unworthy" groups, leading to the physician-administered racial Nuremberg laws, the Sterilization laws, the secret sterilization of Afro-Germans, and the German euthanasia program. This culminated in the extermination camps.