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Sample records for gianfranco minati eliano

  1. Dependability and Performability Analysis

    DTIC Science & Technology

    1993-11-01

    NASA Contractor Report 191565 ICASE Report No. 93-85 (0) ii ICASE U DEPENDABILITY AND PERFORMABILITY ANALYSIS Kishor S. Trivedi Gianfranco Ciardo...PERFORMABILITY ANALYSIS1 Kishor S. Trivedi Gianfranco Ciardo Manish Malhotra Robin A. Sahner Department of Electrical Engineering, Duke University...Trivedi, Gianfranco Ci&rdo, Manish Maihotra, and Robin A. Sahner 7. PERFORMING ORGANIZATION NAME(S) AND ADORESS(ES) 8. PERFORMING ORGANIZATION Institute

  2. Reliability Evaluation of Fault-Tolerant Multiprocessor Systems

    DTIC Science & Technology

    1988-12-08

    Markcv model generation using Stochastic Petri nets. Efficient methods of solving stochastic Petri net models are being investigated by Gianfranco Ciardo...TP’ansactions on Computers, 1988. To appear. [13] Gianfranco Ciardo. Toward a definition of modeling power for stochastic Petri net models. In Proceedings of the... Gianfranco Ciardo, and K. S. Trivedi. The design of a unified package for the solution of stochastic Petri net models. In Proceedings of the Inlernational

  3. The Design of a Unified Package for the Solution of Stochastic Petri Net Models.

    DTIC Science & Technology

    1984-01-01

    SOLUTION OF STOCHASTIC PETRI NET MODELS 12. PERSONAL AUTHOR(S) Kishor S. Trivedi, Gianfranco Ciardo, Andrea Bobbio* and Joanne Bechta Du an 13. TYPE OF...i- Gianfranco Ciardo Ju 3t i , Department of Computer Science . . Duke University Kishor S. Triedi , - • , r I .... ... , . - . Department of Computer...Elsevier Science Publishers, North-Holland, 1977. 5. M. Ajmone Masan, Gianfranco Balbo, and Gianni Conte, "A Class of Generalized Stochas- tic Petri Nets for

  4. Bond Ionicity in Halogen Silver Interaction

    DTIC Science & Technology

    1988-11-01

    Gianfranco Pacchioni Michael R. Philpott Prepared for Publication in DTIC Surface Science ELECTE ~DEC i 2988 IBM Research )ivisibn S OAQ,, H Almaden...AUTHOR(s) 8 CONTRACT OR GRANT NUMBER(s) P. S. Bagus, Gianfranco Pacchioni, M. R. Philpott N00014-82-C-0583 9 PERFORMING ORGANIZATION NAME AND ADDRESS...INTERACTION Paul S. BAGUS, Gianfranco PACCHIONI’, and Michael R. PHILPOTT IBM Research Division, Almaden Research Center, 650 Harry Road, San Jose

  5. Tight Bounds on the Complexity of Parallel Sorting.

    DTIC Science & Technology

    1985-03-01

    Alon, Gianfranco Bilardi, Abbas El Gamal, Jon Greene, Tom Knight, Clyde Kruskal, Charles Leiserson, Gary Miller, Franco Preparata, John Reif, Alan... Gianfranco Bilardi and Franco Preparata for their contributions to this paper. Originally, I had considered the area upper bounds in Theorems 3, 5 and

  6. Parallel and Distributed Computing.

    DTIC Science & Technology

    1986-12-11

    Beaver Harvard Marshall Bern UC Berkeley Gianfranco Bilardi Cornell Adam Bojanczyk Washington University Michael Campbell UC Los Angeles r Larry...50 Gianfranco Bilardi, Cornjll University Bitonic Sorting in 0(log n) Time with 0(n/log n) 1’. Processors 10:00 - 10:50 Nicholas Pippenger, IBM

  7. On the Minimum of Independent Geometrically Distributed Random Variables

    DTIC Science & Technology

    1994-03-01

    RANDOM VARIABLES MAY 24" mD" ,, F Gianfranco Ciardo Lawrence M. Leemis David Nicol 94-15732 for public relecfs* G soGe irA distrutiot It uAlimi"t. DTIC...variables * Gianfranco Ciardo1 Lawrence M. Leemis 2 David Nicol1 Department of Computer Science 2 Department of Mathematics College of William and Mary...Distribution j Availability Codes Avail and i or Dist Speciat "Address for correspondence: Gianfranco Ciardo, Department of Computer Science, College of

  8. Corrections and clarifications.

    PubMed

    1992-12-11

    The price listed for Franco Pavese and Gianfranco Molinar's Modern Gas-Based Temperature and Pressure Measurements (Plenum Press) in the Books Received column of 6 November (p. 1015) was incorrect. The price of the book is $110.

  9. 75 FR 15991 - Designation of Greece for the Visa Waiver Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... / Wednesday, March 31, 2010 / Rules and Regulations#0;#0; ] DEPARTMENT OF HOMELAND SECURITY 8 CFR Part 217 RIN... regulatory requirements. On March 4, 2010, the Secretary of Homeland Security, in consultation with the... CONTACT: Gianfranco Corti, Department of Homeland Security, Office of Policy, (202)...

  10. Modeling the 360° Innovating Firm as a Multiple System or Collective Being

    NASA Astrophysics Data System (ADS)

    Bouchard, Véronique

    Confronted with fast changing technologies and markets and with increasing competitive pressures, firms are now required to innovate fast and continuously. In order to do so, several firms superpose an intrapreneurial layer (IL) to their formal organization (FO). The two systems are in complex relations: the IL is embedded in the FO, sharing human, financial and technical components, but strongly diverges from it when it comes to representation, structure, values and behavior of the shared components. Furthermore, the two systems simultaneously cooperate and compete. In the long run, the organizational dynamics usually end to the detriment of the intrapreneurial layer, which remains marginal or regresses after an initial period of boom. The concepts of Multiple Systems and Collective Beings, proposed by Minati and Pessa, can help students of the firm adopt a different viewpoint on this issue. These concepts can help them move away from a rigid, Manichean view of the two systems' respective functions and roles towards a more fluid and elaborate vision of their relations, allowing for greater flexibility and coherence.

  11. From universe to multiverses--and back again.

    PubMed

    Tjersland, O A

    1990-12-01

    A number of concepts and ideas from constructivist and second-order cybernetic family therapy literature are presented and their implications for therapy are examined. I was inspired by and, in this article, refer to videotapes of consultations and therapy sessions shown at an international conference on constructivism and family therapy in Sulitjelma, Norway, June 1988, and to written material from the Tromsø group (Tom Andersen and Anna M. Flåm), the Milan team (Luigi Boscolo and Gianfranco Cecchin), and the Galveston team (Harlene Anderson and Harold Goolishian). The article also represents an attempt to use constructivist concepts and ideas in a reflection on the author's own professional development as a psychologist and family therapist.

  12. Superconducting Order Parameters with Sign Changes: the Density of States and Impurity Scattering.

    NASA Astrophysics Data System (ADS)

    Preosti, Gianfranco; Muzikar, Paul

    1996-03-01

    We(Gianfranco Preosti is now at: MSD Division, Argonne National Laboratory, Argonne, Illinois 60439.) compute N_s(E) for a family of superconducting order parameters with sign changes at the Fermi surface, and find surprising results. We consider all Δ(hatk) such that Δ(hatk) = + Δ0 on part of the Fermi surface, and Δ(hatk) = - Δ0 on the rest, yielding an average of <Δ(hatk)> = rΔ_0, where 0 <= r <= 1. For 0 < r < 1, as the impurity concentration increases, the number of low-lying states increases, and the superconductor becomes gapless. As the impurity concentration is further increased, the gap in the spectrum is restored, and N_s(E) approaches the pure limit BCS form, with a renormalized gap.

  13. Advances in the understanding of host response associated with tumor PDT

    NASA Astrophysics Data System (ADS)

    Korbelik, Mladen

    2007-02-01

    Photodynamic therapy (PDT) is clinically established modality used for treatment of solid cancers and other conditions, which destroys lesions by localized generation of cytotoxic oxygen species mediated by administered drugs (photosensitizers) that are activated at targeted sites by exposure to light. Since over 20 years ago it has become increasingly clear that important contribution to the antitumor effect of PDT is secured by host reaction induced by this therapy and manifested as inflammatory and immune response. Presented is an overview of advances in the understanding of this host response associated with tumor PDT by tracing its evolution from initial breakthroughs and discoveries in the early 1980s, followed by advances preceding recent developments, and concluding with recently acquired knowledge and directions for clinical exploitation. Tribute is given to researchers making important contributions to this field during the last three decades including Drs. Gianfranco Canti, Julia Levy, and Barbara Henderson.

  14. CD30, Th2 cytokines and HIV infection: a complex and fascinating link.

    PubMed

    Del Prete, G; Maggi, E; Pizzolo, G; Romagnani, S

    1995-02-01

    CD30 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily, and was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. CD30 is preferentially expressed on CD4+ and CD8+ T-cell clones that produce T helper 2 (Th2)-type cytokines, and is also released in a soluble form by these cells. Elevated serum levels of soluble (s)CD30 have been found in some conditions in which a pathogenic role for Th2 cells has been suggested, such as atopy, Omenn's syndrome, systemic lupus erythematosus, as well as following infection with measles virus or human immuno-deficiency virus (HIV). Here, Gianfranco Del Prete and colleagues suggest a complex and fascinating link between the expression and release of CD30, and the immunopathogenesis of HIV infection.

  15. Selecting of a cytochrome P450cam SeSaM library with 3-chloroindole and endosulfan - Identification of mutants that dehalogenate 3-chloroindole.

    PubMed

    Kammoonah, Shaima; Prasad, Brinda; Balaraman, Priyadarshini; Mundhada, Hemanshu; Schwaneberg, Ulrich; Plettner, Erika

    2017-09-18

    Cytochrome P450cam (a camphor hydroxylase) from the soil bacterium Pseudomonas putida shows potential importance in environmental applications such as the degradation of chlorinated organic pollutants. Seven P450cam mutants generated from Sequence Saturation Mutagenesis (SeSaM) and isolated by selection on minimal media with either 3-chloroindole or the insecticide endosulfan were studied for their ability to oxidize of 3-chloroindole to isatin. The wild-type enzyme did not accept 3-chloroindole as a substrate. Mutant (E156G/V247F/V253G/F256S) had the highest maximal velocity in the conversion of 3-chloroindole to isatin, whereas mutants (T56A/N116H/D297N) and (G60S/Y75H) had highest kcat/KM values. Six of the mutants had more than one mutation, and within this set, mutation of residues 297 and 179 was observed twice. Docking simulations were performed on models of the mutant enzymes; the wild-type did not accommodate 3-chloroindole in the active site, whereas all the mutants did. We propose two potential reaction pathways for dechlorination of 3-chloroindole. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Aging, High Altitude, and Blood Pressure: A Complex Relationship.

    PubMed

    Parati, Gianfranco; Ochoa, Juan Eugenio; Torlasco, Camilla; Salvi, Paolo; Lombardi, Carolina; Bilo, Grzegorz

    2015-06-01

    Parati, Gianfranco, Juan Eugenio Ochoa, Camilla Torlasco, Paolo Salvi, Carolina Lombardi, and Grzegorz Bilo. Aging, high altitude, and blood pressure: A complex relationship. High Alt Biol Med 16:97-109, 2015.--Both aging and high altitude exposure may induce important changes in BP regulation, leading to significant increases in BP levels. By inducing atherosclerotic changes, stiffening of large arteries, renal dysfunction, and arterial baroreflex impairment, advancing age may induce progressive increases in systolic BP levels, promoting development and progression of arterial hypertension. It is also known, although mainly from studies in young or middle-aged subjects, that exposure to high altitude may influence different mechanisms involved in BP regulation (i.e., neural central and reflex control of sympathetic activity), leading to important increases in BP levels. The evidence is less clear, however, on whether and to what extent advancing age may influence the BP response to acute or chronic high altitude exposure. This is a question not only of scientific interest but also of practical relevance given the consistent number of elderly individuals who are exposed for short time periods (either for leisure or work) or live permanently at high altitude, in whom arterial hypertension is frequently observed. This article will review the evidence available on the relationship between aging and blood pressure levels at high altitude, the pathophysiological mechanisms behind this complex association, as well as some questions of practical interest regarding antihypertensive treatment in elderly subjects, and the effects of antihypertensive drugs on blood pressure response during high altitude exposure.

  17. NADH reduction of nitroaromatics as a probe for residual ferric form high-spin in a cytochrome P450.

    PubMed

    Pochapsky, Thomas C; Wong, Nathan; Zhuang, Yihao; Futcher, Jeffrey; Pandelia, Maria-Eirini; Teitz, Drew R; Colthart, Allison M

    2017-05-01

    The existence of a substrate-sensitive equilibrium between high spin (S=5/2) and low spin (S=1/2) ferric iron is a well-established phenomenon in the cytochrome P450 (CYP) superfamily, although its origins are still a subject of discussion. A series of mutations that strongly perturb the spin state equilibrium in the camphor hydroxylase CYP101A1 were recently described (Colthart et al., Sci. Rep. 6, 22035 (2016)). Wild type CYP101A1 as well as some CYP101A1 mutants are herein shown to be capable of catalyzing the reduction of nitroacetophenones by NADH to the corresponding anilino compounds (nitroreductase or NRase activity). The distinguishing characteristic between those mutants that catalyze the reduction and those that cannot appears to be the extent to which residual high spin form exists in the absence of the native substrate d-camphor, with those showing the largest spin state shifts upon camphor binding also exhibiting NRase activity. Optical and EPR spectroscopy was used to further examine these phenomena. These results suggest that reduction of nitroaromatics may provide a useful probe of residual high spin states in the CYP superfamily. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Keeping the spotlight on cytochrome P450.

    PubMed

    Shalan, Hadil; Kato, Mallory; Cheruzel, Lionel

    2017-06-06

    This review describes the recent advances utilizing photosensitizers and visible light to harness the synthetic potential of P450 enzymes. The structures of the photosensitizers investigated to date are first presented along with their photophysical and redox properties. Functional photosensitizers range from organic and inorganic complexes to nanomaterials as well as the biological photosystem I complex. The focus is then on the three distinct approaches that have emerged for the activation of P450 enzymes. The first approach utilizes the in situ generation of reactive oxygen species entering the P450 mechanism via the peroxide shunt pathway. The other two approaches are sustained by electron injections into catalytically competent heme domains either facilitated by redox partners or through direct heme domain reduction. Achievements as well as pitfalls of each approach are briefly summarized. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017. Published by Elsevier B.V.

  19. Use of bioconjugation with cytochrome P450 enzymes.

    PubMed

    Ducharme, Julie; Auclair, Karine

    2017-06-16

    Bioconjugation, defined as chemical modification of biomolecules, is widely employed in biological and biophysical studies. It can expand functional diversity and enable applications ranging from biocatalysis, biosensing and even therapy. This review summarizes how chemical modifications of cytochrome P450 enzymes (P450s or CYPs) have contributed to improving our understanding of these enzymes. Genetic modifications of P450s have also proven very useful but are not covered in this review. Bioconjugation has served to gain structural information and investigate the mechanism of P450s via photoaffinity labeling, mechanism-based inhibition (MBI) and fluorescence studies. P450 surface acetylation and protein cross-linking have contributed to the investigation of protein complexes formation involving P450 and its redox partner or other P450 enzymes. Finally, covalent immobilization on polymer surfaces or electrodes has benefited the areas of biocatalysis and biosensor design. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Simulated electrolyte-metal interfaces -- Li3PO4 and Li

    NASA Astrophysics Data System (ADS)

    Xu, Xiao; Du, Yaojun A.; Holzwarth, N. A. W.

    2007-03-01

    There has recently been a lot of interest in solid electrolyte materials such as LiPON developed at Oak Ridge National Laboratory for use in Li-ion batteries and other technologies. We report on the results of our model calculations on idealized interfaces between Li3PO4 and Li metal, studying the structural stability and the ion mobility, using first-principles density functional techniques with the PWscf and pwpaw codes. Starting with a supercell constructed from Li3PO4 in its crystalline γ-phase structure and several layers of Li metal, we used optimization and molecular dynamics techniques to find several meta-stable configurations. The qualitative features of the results are consistent with experimental evidence that the electrolyte is quite stable with respect to Li metal. In addition to stability analyses, we plan to study Li-ion diffusion across the interface. J. B. Bates, N. J. Dudney, and co-workers, Solid State Ionics, 53-56, 647-654 (1992). http://www.pwscf.org and http://pwpaw.wfu.edu. N. J. Dudney in Gholam-Abbas Nazri and Gianfranco Pistoia, Eds., Lithium Batteries: Science and Technology, Chapt. 20, pp. 623-642, Kluwer Academic Publishers, 2004. ISBN 1-4020-7628-2.

  1. Protein engineering of CYP105s for their industrial uses.

    PubMed

    Yasuda, Kaori; Sugimoto, Hiroshi; Hayashi, Keiko; Takita, Teisuke; Yasukawa, Kiyoshi; Ohta, Miho; Kamakura, Masaki; Ikushiro, Shinichi; Shiro, Yoshitsugu; Sakaki, Toshiyuki

    2017-06-02

    Cytochrome P450 enzymes belonging to the CYP105 family are predominantly found in bacteria belonging to the phylum Actinobacteria and the order Actinomycetales. In this review, we focused on the protein engineering of P450s belonging to the CYP105 family for industrial use. Two Arg substitutions to Ala of CYP105A1 enhanced its vitamin D3 25- and 1α-hydroxylation activities by 400 and 100-fold, respectively. The coupling efficiency between product formation and NADPH oxidation was largely improved by the R84A mutation. The quintuple mutant Q87W/T115A/H132L/R194W/G294D of CYP105AB3 showed a 20-fold higher activity than the wild-type enzyme. Amino acids at positions 87 and 191 were located at the substrate entrance channel, and that at position 294 was located close to the heme group. Semi-rational engineering of CYP105A3 selected the best performing mutant, T85F/T119S/V194N/N363Y, for producing pravastatin. The T119S and N363Y mutations synergistically had remarkable effects on the interaction between CYP105A3 and putidaredoxin. Although wild-type CYP105AS1 hydroxylated compactin to 6-epi-pravastatin, the quintuple mutant I95T/Q127R/A180V/L236I/A265N converted almost all compactin to pravastatin. Five amino acid substitutions by two rounds of mutagenesis almost completely changed the stereo-selectivity of CYP105AS1. These results strongly suggest that the protein engineering of CYP105 enzymes greatly increase their industrial utility. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Cytochrome P450 diversity in the tree of life.

    PubMed

    Nelson, David R

    2017-05-11

    Sequencing in all areas of the tree of life has produced >300,000 cytochrome P450 (CYP) sequences that have been mined and collected. Nomenclature has been assigned to >41,000 CYP sequences and the majority of the remainder has been sorted by BLAST searches into clans, families and subfamilies in preparation for naming. The P450 sequence space is being systematically explored and filled in. Well-studied groups like vertebrates are covered in greater depth while new insights are being added into uncharted territories like horseshoe crab (Limulus polyphemus), tardigrades (Hypsibius dujardini), velvet worm (Euperipatoides_rowelli), and basal land plants like hornworts, liverworts and mosses. CYPs from the fungi, one of the most diverse groups, are being explored and organized as nearly 800 fungal species are now sequenced. The CYP clan structure in fungi is emerging with 805 CYP families sorting into 32 CYP clans. >3000 bacterial sequences are named, mostly from terrestrial or freshwater sources. Of 18,379 bacterial sequences downloaded from the CYPED database, all are >43% identical to named CYPs. Therefore, they fit in the 602 named P450 prokaryotic families. Diversity in this group is becoming saturated, however 25% of 3305 seawater bacterial P450s did not match known P450 families, indicating marine bacterial CYPs are not as well sampled as land/freshwater based bacterial CYPs. Future sequencing plans of the Genome 10K project, i5k and GIGA (Global Invertebrate Genomics Alliance) are expected to produce more than one million cytochrome P450 sequences by 2020. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Spectroscopic studies of the cytochrome P450 reaction mechanisms.

    PubMed

    Mak, Piotr J; Denisov, Ilia G

    2017-06-28

    The cytochrome P450 monooxygenases (P450s) are thiolate heme proteins that can, often under physiological conditions, catalyze many distinct oxidative transformations on a wide variety of molecules, including relatively simple alkanes or fatty acids, as well as more complex compounds such as steroids and exogenous pollutants. They perform such impressive chemistry utilizing a sophisticated catalytic cycle that involves a series of consecutive chemical transformations of heme prosthetic group. Each of these steps provides a unique spectral signature that reflects changes in oxidation or spin states, deformation of the porphyrin ring or alteration of dioxygen moieties. For a long time, the focus of cytochrome P450 research was to understand the underlying reaction mechanism of each enzymatic step, with the biggest challenge being identification and characterization of the powerful oxidizing intermediates. Spectroscopic methods, such as electronic absorption (UV-Vis), electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), electron nuclear double resonance (ENDOR), Mössbauer, X-ray absorption (XAS), and resonance Raman (rR), have been useful tools in providing multifaceted and detailed mechanistic insights into the biophysics and biochemistry of these fascinating enzymes. The combination of spectroscopic techniques with novel approaches, such as cryoreduction and Nanodisc technology, allowed for generation, trapping and characterizing long sought transient intermediates, a task that has been difficult to achieve using other methods. Results obtained from the UV-Vis, rR and EPR spectroscopies are the main focus of this review, while the remaining spectroscopic techniques are briefly summarized. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Insights into the functional properties of the marneral oxidase CYP71A16 from Arabidopsis thaliana.

    PubMed

    Kranz-Finger, Sarah; Mahmoud, Osama; Ricklefs, Esther; Ditz, Nikolas; Bakkes, Patrick J; Urlacher, Vlada B

    2017-07-19

    The Arabidopsis thaliana gene encoding CYP71A16 is part of the gene cluster for the biosynthesis and modification of the triterpenoid marneral. Previous investigations of A. thaliana have revealed that CYP71A16 catalyzes marneral oxidation, while it also can accept marnerol as substrate. The aim of the present study was to investigate functional properties of CYP71A16 in vitro. For this purpose, heterologous expression of a N-terminally modified version of CYP71A16 was established in Escherichia coli, which yielded up to 50mgL(-1) recombinant enzyme. The enzyme was purified and activity was reconstituted in vitro with different redox partners. A heterologous bacterial redox partner system consisting of the flavodoxin YkuN from Bacillus subtilis and the flavodoxin reductase Fpr from E. coli clearly outperformed the cytochrome P450 reductase ATR2 from A. thaliana in supporting the CYP71A16-mediated hydroxylation of marnerol. Substrate binding experiments with CYP71A16 revealed a dissociation constant KD of 225μM for marnerol. CYP71A16 catalyzed the hydroxylation of marnerol to 23-hydroxymarnerol with a KM of 142μM and a kcat of 3.9min(-1). Furthermore, GC/MS analysis revealed an as of yet unidentified overoxidation product of this in vitro reaction. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017. Published by Elsevier B.V.

  5. Modulation of the interaction between human P450 3A4 and B. megaterium reductase via engineered loops.

    PubMed

    Castrignanò, Silvia; D'Avino, Serena; Di Nardo, Giovanna; Catucci, Gianluca; Sadeghi, Sheila J; Gilardi, Gianfranco

    2017-07-19

    Chimerogenesis involving cytochromes P450 is a successful approach to generate catalytically self-sufficient enzymes. However, the connection between the different functional modules should allow a certain degree of flexibility in order to obtain functional and catalytically efficient proteins. We previously applied the molecular Lego approach to develop a chimeric P450 3A4 enzyme linked to the reductase domain of P450 BM3 (BMR). Three constructs were designed with the connecting loop containing no glycine, 3 glycine or 5 glycine residues and showed a different catalytic activity and coupling efficiency. Here we investigate how the linker affects the ability of P450 3A4 to bind substrates and inhibitors. We measure the electron transfer rates and the catalytic properties of the enzyme also in the presence of ketoconazole as inhibitor. The data show that the construct 3A4-5GLY-BMR with the longest loop better retains the binding ability and cooperativity for testosterone, compared to P450 3A4. In both 3A4-3GLY-BMR and 3A4-5GLY-BMR, the substrate induces an increase in the first electron transfer rate and a shorter lag phase related to a domain rearrangements, when compared to the construct without Gly. These data are consistent with docking results and secondary structure predictions showing a propensity to form helical structures in the loop of the 3A4-BMR and 3A4-3GLY-BMR. All three chimeras retain the ability to bind the inhibitor ketoconazole and show an IC50 comparable with those reported for the wild type protein. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  6. Slope instability mapping around L'Aquila (Abruzzo, Italy) with Persistent Scatterers Interferometry from ERS, ENVISAT and RADARSAT datasets

    NASA Astrophysics Data System (ADS)

    Righini, Gaia; Del Conte, Sara; Cigna, Francesca; Casagli, Nicola

    2010-05-01

    Forum. 16-19 November 2008 Tokyo Japan, 125-128. Colesanti, C., Ferretti, A., Prati, C., Rocca, F. (2003). Monitoring landslides and tectonic motions with the Permanent Scatterers Technique. Engineering Geology, 68, 3 - 14. Colesanti, C., Wasowski, J., (2006). Investigating landslides with satellite Synthetic Aperture Radar (SAR) interferometry. Engineering Geology, 88 (3 - 4), 173 - 199. Cruden, D.M., Varnes, D.J. (1996). Landslide types and processes. In: Turner AK, Schuster RL (eds) Landslides investigation and mitigation, Special Report 247. Transportation Research Board, National Research Council, Washington, DC, 36 - 75. Farina P., Colombo D., Fumagalli A., Marks F., Moretti S. (2006) - Permanent Scatterers for landslide investigations: outcomes from the ESA-SLAM project. Engineering Geology, v. 88, p.200-217. Farina P., Casagli N., Ferretti A. (2008) - Radar-interpretation of InSAR measurements for landslide investigations in civil protection practices. First North American Landslide Conference, June 3-8, 2007.Vail, Colorado, pp. 272-283. Hilley, G.E, Burgmann, R., Ferretti, A., Novali, F., Rocca, F. (2004). Dynamics of slow-moving landslides from Permanent Scatterer analysis. Science, 304 (5679), 1952 - 1955. Herrera G., Davalillo J.C., Mulas J., Cooksley G., Monserrat O., Pancioli V. (2009) - Mapping and monitoring geomorphological processes in mountainous areas using PSI data: Central Pyrenees case study Nat. Hazards Earth Syst. Sci., 9, 1587-1598, Meisina C., Zucca F., Fossati D., Ceriani M, Allievi J. (2006) - Ground deformations monitoring by using the Permanent Scatterers Technique: the example of the Oltrepo Pavese (Lombardia, Italy), Engineering Geology, 88, 240-259. Pancioli V., Farina P., (2007) - Analisi dei fenomeni franosi con dati InSAR satellitari: primi risultati del progetto ESA-Terrafirma. Giornale di Geologia Applicata 6-A: 101-102. Righini, G., Del Ventisette, C., Costantini, M., Malvarosa, F., Minati, F. (2008). Space-borne SAR Analysis for

  7. Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus.

    PubMed

    Lemaire, Benjamin; Karchner, Sibel I; Goldstone, Jared V; Lamb, David C; Drazen, Jeffrey C; Rees, Jean François; Hahn, Mark E; Stegeman, John J

    2017-07-08

    proper folding at 1atm, indicating that they could be used as deep-sea fish protein models to further evaluate protein function under pressure. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone". Copyright © 2017 Elsevier B.V. All rights reserved.

  8. List of Participants

    NASA Astrophysics Data System (ADS)

    Bombaci, I.; Covello, A.; Marcucci, L. E.; Rosati, S.

    2009-07-01

    Armani Paolo (Università di Trento) Benhar Omar (INFN Roma) Bombaci Ignazio (Università di Pisa) Bonanno Luca (Università di Ferrara) Catara Francesco (Università di Catania) Cò Giampaolo (Università di Lecce) Colonna Maria (Laboratori Nazionali del Sud, INFN Catania) Colonna Nicola (INFN Bari) Conti Francesco (Università di Pavia) Coraggio Luigi (INFN Napoli) Covello Aldo (Università di Napoli) Cristoforetti Marco (Technische Universität München, Germania) Cuofano Carmine (Università di Ferrara) Di Toro Massimo (Università di Catania) Drago Alessandro (Università di Ferrara) Faccioli Pietro (Università di Trento) Farina Nicola (INFN Roma) Finelli Paolo (Università di Bologna) Fiorentini Giovanni (Università di Ferrara) Fortunato Lorenzo (Università di Padova) Gambacurta Danilo (Università di Catania) Gandolfi Stefano (Università di Trento) Gargano Angela (INFN Napoli) Giannini Mauro (Università di Genova) Girlanda Luca (INFN Pisa) Giusti Carlotta (INFN Pavia) Illarionov Alexei (SISSA Trieste) Itaco Nunzio (Università di Napoli) Kievsky Alejandro (INFN Pisa) Lanza Edoardo (INFN Catania) Leidemann Winfried (Università di Trento) Lenzi Silvia (Università di Padova) Lipparini Enrico (Università di Trento) Lissia Marcello (Università di Cagliari) Lo Iudice Nicola (Università di Napoli) Maieron Chiara (Università di Lecce) Marcucci Laura Elisa (Università di Pisa) Matera Francesco (Università di Firenze) Millo Raffaele (Università di Trento) Orlandini Giuseppina (Università di Trento) Pacati Franco (Università di Pavia) Pastore Alessandro (Univeristy of Jyväskylä, Finlandia) Pederiva Francesco (Università di Trento) Pisent Gualtiero (Università di Padova) Prete Gianfranco (INFN Laboratori Nazionali di Legnaro) Quarati Piero (Politecnico di Torino) Rosati Sergio (Università di Pisa) Salmè Giovanni (INFN Roma) Santopinto Elena (INFN Genova) Traini Marco (Università di Trento) Vigezzi Enrico (INFN Milano) Vitturi Andrea (Universit

  9. PREFACE: 12th Conference on ''Theoretical Nuclear Physics in Italy''

    NASA Astrophysics Data System (ADS)

    Bombaci, I.; Covello, A.; Marcucci, L. E.; Rosati, S.

    2009-07-01

    These Proceedings contain the invited and contributed papers presented at the 12th Conference on Theoretical Nuclear Physics in Italy held in Cortona, Italy, from 8-10 October 2008. As usual, the meeting was held at il Palazzone, a 16th century castle owned by the Scuola Normale Superiore di Pisa. The aim of this biennal conference is to bring together Italian theorists working in various fields of Nuclear Physics to discuss their latest results and confront their points of view in a lively and informal way. This offers the opportunity to promote collaborations between different groups. There were about 50 participants at the conference, coming from 14 Italian Universities (Cagliari, Catania, Ferrara, Firenze, Genova, Lecce, Milano, Napoli, Padova, Pavia, Pisa, Roma, Trento, Trieste). The program of the conference, prepared by the Organizing Committee (Ignazio Bombaci, Aldo Covello, Laura Elisa Marcucci and Sergio Rosati) focused on six main topics: Few-Nucleon Systems, Nuclear Matter and Nuclear Dynamics, Nuclear Astrophysics, Structure of Hadrons and Hadronic Matter, Nuclear Structure, Nuclear Physics with Electroweak Probes. Winfried Leidemann, Maria Colonna, Marcello Lissia, Elena Santopinto, Silvia Lenzi and Omar Benhar took the burden of giving general talks on these topics and reviewing the research activities of the various Italian groups. In addition, 19 contributed papers were presented, most of them by young participants. In the last session of the Conference there were two invited talks related to experimental activities of great current interest. Gianfranco Prete from the Laboratori Nazionali di Legnaro spoke about the Italian radioactive ion beam facility SPES and the status of the European project EURISOL, while Nicola Colonna from the INFN, Bari, gave an overview of the perspectives of development of fourth-generation nuclear reactors. We would like to thank the authors of the general reports for their hard work in reviewing the main achievements in

  10. Functionalized poly(3-hydroxybutyric acid) bodies as new in vitro biocatalysts.

    PubMed

    Stenger, Benjamin; Gerber, Adrian; Bernhardt, Rita; Hannemann, Frank

    2017-09-01

    Cytochromes P450 play a key role in the drug and steroid metabolism in the human body. This leads to a high interest in this class of proteins. Mammalian cytochromes P450 are rather delicate. Due to their localization in the mitochondrial or microsomal membrane, they tend to aggregate during expression and purification and to convert to an inactive form so that they have to be purified and stored in complex buffers. The complex buffers and low storage temperatures, however, limit the feasibility of fast, automated screening of the corresponding cytochrome P450-effector interactions, which are necessary to study substrate-protein and inhibitor-protein interactions. Here, we present the production and isolation of functionalized poly(3-hydroxybutyrate) granules (PHB bodies) from Bacillus megaterium MS941 strain. In contrast to the expression in Escherichia coli, where mammalian cytochromes P450 are associated to the cell membrane, when CYP11A1 is heterologously expressed in Bacillus megaterium, it is located on the PHB bodies. The surface of these particles provides a matrix for immobilization and stabilization of the CYP11A1 during the storage of the protein and substrate conversion. It was demonstrated that the PHB polymer basis is inert concerning the performed conversion. Immobilization of the CYP11A1 onto the PHB bodies allows freeze-drying of the complex without significant decrease of the CYP11A1 activity. This is the first lyophilization of a mammalian cytochrome P450, which allows storage over more than 18days at 4°C instead of storage at -80°C. In addition, we were able to immobilize the cytochrome P450 on the PHB bodies in vitro. In this case the expression of the protein is separated from the production of the immobilization matrix, which widens the application of this method. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared

  11. Identification of endocrine disrupting chemicals acting on human aromatase.

    PubMed

    Baravalle, Roberta; Ciaramella, Alberto; Baj, Francesca; Di Nardo, Giovanna; Gilardi, Gianfranco

    2017-06-01

    chemicals. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. PREFACE: DISCRETE 2010: Symposium on Prospects in the Physics of Discrete Symmetries

    NASA Astrophysics Data System (ADS)

    Di Domenico, Antonio; Bini, Cesare; Bloise, Caterina; Bossi, Fabio; Faccini, Riccardo; Gauzzi, Paolo; Isidori, Gino; Lipari, Paolo; Ludovici, Lucio; Silvestrini, Luca

    2011-12-01

    The Symposium DISCRETE2010 on Prospects in the Physics of Discrete Symmetries was held at the Sapienza Universitàa di Roma, Italy from 6-11 December 2010. This second edition, after the successful one in Valencia in 2008, covered all theoretical and experimental progress in the field, and aimed at a thorough discussion on the latest developments. The topics covered included: T, C, P, CP symmetries; accidental symmetries (B, L conservation); CPT symmetry, decoherence, Lorentz symmetry breaking; neutrino mass and mixing; cosmology and astroparticles, dark matter searches; experimental prospects at LHC, Super flavor factories, and new facilities. The Symposium was organized in plenary sessions with a total of 23 invited talks, and parallel sessions with a total of 80 talks including both invited and selected contributions from the submitted abstracts. The speakers of the plenary sessions were: Achille Stocchi, Andreas Weiler, Kevin Pitts, Tim Gershon, Marco Sozzi, Neal Weiner, Vasiliki Mitsou, Bernard Sadoulet, Gianfranco Bertone, J. Eric Grove, Mauro Mezzetto, Alexei Yu Smirnov, Oliviero Cremonesi, Antonio Riotto, Reno Mandolesi, Brett Altschul, Jose Bernabeu, Lawrence Hall, Marco Grassi, Yannis K. Semertzidis, Riccardo Barbieri, Gigi Rolandi, Luciano Maiani. The Symposium venue was the CNR (Consiglio Nazionale delle Ricerche) headquarter building, close to the Sapienza University. At the end of the Symposium a special open session, devoted to a wider audience, was held at the Pontifical University of the Holy Cross, in the historical center of Rome. The symposium was attended by about 140 participants, about half coming from Italy, and the rest mainly from other European countries and United States. Among the social events was a concert at the Aula Magna of the Sapienza University, and a social dinner in the historical Palazzo Pallavicini-Rospigliosi on the Quirinale Hill. The next symposium of the series will be organised by IST, Universidade Tàecnica de Lisboa

  13. CYP106A2 - a versatile biocatalyst with high potential for biotechnological production of selectively hydroxylated steroid and terpenoid compounds.

    PubMed

    Schmitz, Daniela; Janocha, Simon; Kiss, Flora Marta; Bernhardt, Rita

    2017-08-02

    by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017. Published by Elsevier B.V.

  14. The MIT Program, Competition, and Ethics

    NASA Astrophysics Data System (ADS)

    Bradt, Hale V.

    2013-01-01

    The MIT program in x-ray astronomy was, and still is, diverse and productive. Bruno Rossi and later George Clark, as the nominal leaders of the “x-ray astronomy group” created a “hands-off” culture wherein individual researchers could develop their own independent programs. Walter Lewin, Claude Canizares, and I as well as those in the next academic generations, e.g., Saul Rappaport and George Ricker, were able to thrive in this environment. MIT researchers were principal investigators or providers of x-ray instruments on sounding rockets and balloons in the 1960s and then in later years on nine satellite missions, OSO-7, SAS-3, HEAO-1, Einstein, ASCA, RXTE, Chandra, HETE-2, and Suzaku. Such a diverse program involved collaborations with other institutions and of course striving for primacy in discovery and competition for NASA resources. Looking back, I see a high degree of ethical behavior among the observational x-ray community during those years. In competition, we remembered that we might well be collaborating the following year and behaved accordingly. Many of us in the x-ray community had been friends since graduate school days and did not want to lose those relationships. Am I viewing the past through rose colored glasses? I think not. A vignette on this topic: In 1967, I was debating vigorously with Herb Gursky of AS&E about which institution, MIT or AS&E, should be the lead on the fourth paper (Oda et al. 1967, ApJ 148, L5) based on data from the 1966 AS&E rocket flight which had led to Allan Sandage’s (and Japanese) identification of Sco X-1 (Sandage, et al. 1966, ApJ. 146, 316). I and my Italian colleague, Gianfranco Spada, and our Japanese colleague, Minoru Oda, both then visiting MIT, had actively supported that flight. After one rather heated discussion with Herb about this, - I was the heated one; he always remained calm - he left my office saying: “Hale, however this comes out, let’s remain friends.” I treasured that comment and

  15. Memorial to Professor Antonio Barone

    NASA Astrophysics Data System (ADS)

    Tafuri, Francesco; Pepe, Giampiero; Vaglio, Ruggero

    2014-04-01

    Antonio Barone prematurely passed away on 4 December 2011 at the age of 72, after a one-year battle with cancer. He left behind his wife Sveva and his two sons, Alberto and Livio. Antonio was Professor Emeritus at the University of Napoli Federico II, where he had been teaching for about 40 years. The initial research activity of Antonio was in the field of nuclear physics. In this context, almost 45 years ago, the Ge 'Lithium drift' semiconductor detectors represented a novelty, due to the high energy resolution enabled by those devices. Superconductors stimulated new approaches to radiation detection and this motivated Antonio's interest towards superconductivity. Following the birth of the Laboratorio di Cibernetica of the CNR in 1967 he was given the opportunity to work on a joint USA-Italy project (University of Wisconsin, Madison and CNR Naples) in the field of superconductivity on the peculiar subject of the superconductive 'Neuristors'. His research activity on Josephson junctions opened up a wide variety of very stimulating subjects in which he was deeply involved, ranging from the soliton propagation in 'long' Josephson structures to fluctuations phenomena, from light-sensitive junctions and proximity effect to the development of innovative superconducting devices. The strong interaction of Antonio with the Landau Institute for Theoretical Physics of the Academy of Sciences in Moscow, characterizes a long period of his research activity with a precious merging of theoretical and experimental aspects. This body of work converged into the famous monograph on the 'Physics and Applications of the Josephson Effect', written in collaboration with Gianfranco Paternò in 1982. This rapidly became the reference text for the Josephson effect, as documented by thousands of citations and the fact that it was translated into Russian, Japanese and Chinese. In 1983 Antonio was awarded the highest academic title of 'Doctor of the Physical-Mathematical Sciences' by the

  16. FOREWORD: The 4th CCM International Conference on Pressure Metrology from Ultra-High Vacuum to Very High Pressures (10-9 Pa to 109 Pa)

    NASA Astrophysics Data System (ADS)

    Legras, Jean-Claude; Jousten, Karl; Severn, Ian

    2005-12-01

    , particularly Gianfranco Molinar who offered much advice based on experience of organizing the previous conference. Special thanks must also be made to Mitsuru Tanaka, President of the CCM, and Andrew Wallard, Director of the BIPM, for their support of the event. The event was coordinated by Jasmina Bolfek-Radovani, of the Institute of Physics, without whose tireless efforts the event would not have been as successful. The production of this issue of Metrologia would not have been possible without the help and support of its editor, Jeffrey Williams. The National Measurement System Directorate of the Department of Trade and Industry supported the conference and it was sponsored by DH Instruments and BOC Edwards. Additional financial assistance was also received from Chell Instruments Ltd, DH-Budenberg, GE Infrastructure Sensing, Hi-Pro Pressure Products Ltd, Kurt J Lesker Company Ltd and Leybold Vacuum UK Ltd. Finally we would like to thank all of the conference participants who made the event both technically stimulating and enjoyable. By the time the next CCM Pressure conference is held in Berlin in 2011, pressure science and technology will undoubtedly have moved on still further and we may see the culmination of work to realize primary pressure standards by more fundamental methods.

  17. EDITORIAL: Focus on Dark Matter and Particle Physics

    NASA Astrophysics Data System (ADS)

    Aprile, Elena; Profumo, Stefano

    2009-10-01

    Doetinchem, H Gast, T Kirn and S Schael Axion searches with helioscopes and astrophysical signatures for axion(-like) particles K Zioutas, M Tsagri, Y Semertzidis, T Papaevangelou, T Dafni and V Anastassopoulos The indirect search for dark matter with IceCube Francis Halzen and Dan Hooper DIRECT DARK MATTER SEARCHES:EXPERIMENTS Gaseous dark matter detectors G Sciolla and C J Martoff Search for dark matter with CRESST Rafael F Lang and Wolfgang Seidel DIRECT AND INDIRECT PARTICLE DARK MATTER SEARCHES:THEORY Dark matter annihilation around intermediate mass black holes: an update Gianfranco Bertone, Mattia Fornasa, Marco Taoso and Andrew R Zentner Update on the direct detection of dark matter in MSSM models with non-universal Higgs masses John Ellis, Keith A Olive and Pearl Sandick Dark stars: a new study of the first stars in the Universe Katherine Freese, Peter Bodenheimer, Paolo Gondolo and Douglas Spolyar Determining the mass of dark matter particles with direct detection experiments Chung-Lin Shan The detection of subsolar mass dark matter halos Savvas M Koushiappas Neutrino coherent scattering rates at direct dark matter detectors Louis E Strigari Gamma rays from dark matter annihilation in the central region of the Galaxy Pasquale Dario Serpico and Dan Hooper DARK MATTER MODELS The dark matter interpretation of the 511 keV line Céline Boehm Axions as dark matter particles Leanne D Duffy and Karl van Bibber Sterile neutrinos Alexander Kusenko Dark matter candidates Lars Bergström Minimal dark matter: model and results Marco Cirelli and Alessandro Strumia Shedding light on the dark sector with direct WIMP production Partha Konar, Kyoungchul Kong, Konstantin T Matchev and Maxim Perelstein Axinos as dark matter particles Laura Covi and Jihn E Kim

  18. PREFACE: Proceedings of the TeV Particle Astrophysics II Workshop

    NASA Astrophysics Data System (ADS)

    Halzen, F.; Karle, A.; Montaruli, T.

    2007-03-01

    people from the various fields of Astroparticle Physics. Acknowledgements Due to the high quality of help that we received from them, we wish to acknowledge the conveners of the Working Groups mentioned in the text with the same numbering used above: 1) Felix Aharonian, Gus Sinnis, Frank Krennrich and Masahiro Teshima; 2) Piera Ghia and Tom Gaisser; 3) Laura Baudis and Gianfranco Bertone; 4) Lutz Koepke and Dan Hooper; 5) David Saltzberg and David Waters; 6) Ivone Albuquerque, Alexander Kusenko and Tom Weiler; and Bruce Allen and Guido Mueller. Special thanks also go to Tom Gaisser, who gave a comprehensive final summary of the conference. Throughout the Conference and the collection of these proceedings, Kim Kreiger constantly supported us. She was also responsible for the wonderful food available at coffee breaks and at the social dinner! (The PDF file lists the IceCube Collaboration) T Montaruli

  19. COSMO 09

    ScienceCinema

    None

    2016-07-12

    This year's edition of the annual Cosmo International Conference on Particle Physics and Cosmology -- Cosmo09 -- will be hosted by the CERN Theory Group from Monday September 7 till Friday September 11, 2009. The conference will take place at CERN, Geneva (Switzerland). The Cosmo series is one of the major venues of interaction between cosmologists and particle physicists. In the exciting LHC era, the Conference will be devoted to the modern interfaces between Fundamental and Phenomenological Particle Physics and Physical Cosmology and Astronomy. The Conference will be followed by the CERN TH Institute "Particle Cosmology" which will take place from Monday September 14 till Friday September 18, 2009. The CERN-TH Institutes are visitor programs intended to bring together scientists with similar interests and to promote scientific collaborations. If you wish to participate, please register on the Institute web page. Link to last editions: COSMO 07 (U. of Sussex), COSMO 08 (U. of Wisconsin) List of plenary speakers: Gianfranco Bertone, Pierre Binetruy, Francois Bouchet, Juerg Diemand, Jonathan Feng, Gregory Gabadadze, Francis Halzen, Steen Hannestad, Will Kinney, Johannes Knapp, Hiranya Peiris, Will Percival, Syksy Rasanen, Alexandre Refregier, Pierre Salati, Roman Scoccimarro, Michael Schubnell, Christian Spiering, Neil Spooner, Andrew Tolley, Matteo Viel. The plenary program is available on-line. Select "Preliminary programme" in the left menu and click on each plenary session to see details. Parallel sessions: Inflation, convenor: Andrew Liddle Dark matter, convenor: Marco Cirelli Dark energy and modified gravity, convenor: Kazuya Koyama CMB, LSS and cosmological parameters/models, convenor: Licia Verde String cosmology, convenor: Jim Cline Baryogenesis and leptogenesis, convenor: Mariano Quiros The submission of talk proposals is closed by now. The parallel session program is available on-line. Select "Preliminary programme" in the left menu and click on each

  20. COSMO 09

    SciTech Connect

    2009-09-07

    This year's edition of the annual Cosmo International Conference on Particle Physics and Cosmology -- Cosmo09 -- will be hosted by the CERN Theory Group from Monday September 7 till Friday September 11, 2009. The conference will take place at CERN, Geneva (Switzerland). The Cosmo series is one of the major venues of interaction between cosmologists and particle physicists. In the exciting LHC era, the Conference will be devoted to the modern interfaces between Fundamental and Phenomenological Particle Physics and Physical Cosmology and Astronomy. The Conference will be followed by the CERN TH Institute "Particle Cosmology" which will take place from Monday September 14 till Friday September 18, 2009. The CERN-TH Institutes are visitor programs intended to bring together scientists with similar interests and to promote scientific collaborations. If you wish to participate, please register on the Institute web page. Link to last editions: COSMO 07 (U. of Sussex), COSMO 08 (U. of Wisconsin) List of plenary speakers: Gianfranco Bertone, Pierre Binetruy, Francois Bouchet, Juerg Diemand, Jonathan Feng, Gregory Gabadadze, Francis Halzen, Steen Hannestad, Will Kinney, Johannes Knapp, Hiranya Peiris, Will Percival, Syksy Rasanen, Alexandre Refregier, Pierre Salati, Roman Scoccimarro, Michael Schubnell, Christian Spiering, Neil Spooner, Andrew Tolley, Matteo Viel. The plenary program is available on-line. Select "Preliminary programme" in the left menu and click on each plenary session to see details. Parallel sessions: Inflation, convenor: Andrew Liddle Dark matter, convenor: Marco Cirelli Dark energy and modified gravity, convenor: Kazuya Koyama CMB, LSS and cosmological parameters/models, convenor: Licia Verde String cosmology, convenor: Jim Cline Baryogenesis and leptogenesis, convenor: Mariano Quiros The submission of talk proposals is closed by now. The parallel session program is available on-line. Select "Preliminary programme" in the left menu and click on each

  1. COSMO 09

    ScienceCinema

    None

    2016-07-12

    This year's edition of the annual Cosmo International Conference on Particle Physics and Cosmology -- Cosmo09 -- will be hosted by the CERN Theory Group from Monday September 7 till Friday September 11, 2009. The conference will take place at CERN, Geneva (Switzerland). The Cosmo series is one of the major venues of interaction between cosmologists and particle physicists. In the exciting LHC era, the Conference will be devoted to the modern interfaces between Fundamental and Phenomenological Particle Physics and Physical Cosmology and Astronomy. The Conference will be followed by the CERN TH Institute "Particle Cosmology" which will take place from Monday September 14 till Friday September 18, 2009. The CERN-TH Institutes are visitor programs intended to bring together scientists with similar interests and to promote scientific collaborations. If you wish to participate, please register on the Institute web page. Link to last editions: COSMO 07 (U. of Sussex), COSMO 08 (U. of Wisconsin) List of plenary speakers: Gianfranco Bertone, Pierre Binetruy, Francois Bouchet, Juerg Diemand, Jonathan Feng, Gregory Gabadadze, Francis Halzen, Steen Hannestad, Will Kinney, Johannes Knapp, Hiranya Peiris, Will Percival, Syksy Rasanen, Alexandre Refregier, Pierre Salati, Roman Scoccimarro, Michael Schubnell, Christian Spiering, Neil Spooner, Andrew Tolley, Matteo Viel. The plenary program is available on-line. Select "Preliminary programme" in the left menu and click on each plenary session to see details. Parallel sessions: Inflation, convenor: Andrew Liddle Dark matter, convenor: Marco Cirelli Dark energy and modified gravity, convenor: Kazuya Koyama CMB, LSS and cosmological parameters/models, convenor: Licia Verde String cosmology, convenor: Jim Cline Baryogenesis and leptogenesis, convenor: Mariano Quiros The submission of talk proposals is closed by now. The parallel session program is available on-line. Select "Preliminary programme" in the left menu and click on each

  2. COSMO 09

    SciTech Connect

    2009-09-07

    This year's edition of the annual Cosmo International Conference on Particle Physics and Cosmology -- Cosmo09 -- will be hosted by the CERN Theory Group from Monday September 7 till Friday September 11, 2009. The conference will take place at CERN, Geneva (Switzerland). The Cosmo series is one of the major venues of interaction between cosmologists and particle physicists. In the exciting LHC era, the Conference will be devoted to the modern interfaces between Fundamental and Phenomenological Particle Physics and Physical Cosmology and Astronomy. The Conference will be followed by the CERN TH Institute "Particle Cosmology" which will take place from Monday September 14 till Friday September 18, 2009. The CERN-TH Institutes are visitor programs intended to bring together scientists with similar interests and to promote scientific collaborations. If you wish to participate, please register on the Institute web page. Link to last editions: COSMO 07 (U. of Sussex), COSMO 08 (U. of Wisconsin) List of plenary speakers: Gianfranco Bertone, Pierre Binetruy, Francois Bouchet, Juerg Diemand, Jonathan Feng, Gregory Gabadadze, Francis Halzen, Steen Hannestad, Will Kinney, Johannes Knapp, Hiranya Peiris, Will Percival, Syksy Rasanen, Alexandre Refregier, Pierre Salati, Roman Scoccimarro, Michael Schubnell, Christian Spiering, Neil Spooner, Andrew Tolley, Matteo Viel. The plenary program is available on-line. Select "Preliminary programme" in the left menu and click on each plenary session to see details. Parallel sessions: Inflation, convenor: Andrew Liddle Dark matter, convenor: Marco Cirelli Dark energy and modified gravity, convenor: Kazuya Koyama CMB, LSS and cosmological parameters/models, convenor: Licia Verde String cosmology, convenor: Jim Cline Baryogenesis and leptogenesis, convenor: Mariano Quiros The submission of talk proposals is closed by now. The parallel session program is available on-line. Select "Preliminary programme" in the left menu and click on each

  3. Hot Spot Cosmic Accelerators

    NASA Astrophysics Data System (ADS)

    2002-11-01

    cosmic objects. Notes [1]: The new results are described in a research paper, "Particle Accelerators in the Hot Spots of Radio Galaxy 3C 445, Imaged with the VLT" by M. Almudena Prieto (ESO, Garching, Germany), Gianfranco Brunetti (Istituto de Radioastronomia del CNR, Bologna, Italy) and Karl-Heinz Mack (Istituto de Radioastronomia del CNR, Bologna, Italy; ASTRON/NFRA, Dwingeloo, The Netherlands; Radioastronomisches Institut der Universität Bonn, Germany), that recently appeared in the research journal Science (Vol. 298, pp. 193-195). [2]: When electrons - which are electrically charged - move through a magnetic field, they spiral along the lines of force. Electrons of high energy spiral very rapidly, at speeds near the speed of light. Under such conditions, the electrons emit highly polarized electromagnetic radiation. The intensity of this radiation is related to the strength of the magnetic field and the number and energy distribution of the electrons caught in this field. Many cosmic radio sources have been found to emit synchrotron radiation - one of the best examples is the famous Crab Nebula, depicted in ESO PR Photo 40f/99. ESO PR Photo 26/02 may be reproduced, if credit is given to the European Southern Observatory (ESO) and the US National Radio Astronomy Observatory (NRAO).

  4. Ghostly Glow Reveals a Hidden Class of Long-Wavelength Radio Emitters

    NASA Astrophysics Data System (ADS)

    2008-10-01

    Chandra X-ray Observatory. X-ray Chandra X-ray Image The X-ray emission comes from hot thermal gas, a well-known sign-post of massive galaxy clusters. Furthermore, its elongated shape indicates that the cluster has undergone a recent violent collision or "merger event" in which another group or cluster of galaxies was swallowed up by the gravitational potential of the main cluster. Interferometrics Inc. and NRL scientist Tracy Clarke, who is also the LWA System Scientist, notes "In addition to teaching us about the nature of Dark Matter, merging clusters are also important in studies of the mysterious nature of Dark Energy. Understanding these two strange components of the Universe will help us understand its ultimate destiny." In the radio image there is a strong, oblong source of emission located on the lower left periphery of the X-ray gas detected by Chandra; this is a separate source. In the center of the cluster, within the region indicated by a dashed circle, there is radio emission which changes significantly with wavelength. At the longest wavelength (125 cm, shown) it is clearly detected, but at a wavelength of 49 cm it is much fainter, and it is almost entirely gone at 21 cm wavelength. This multi-wavelength picture of the diffuse emission is in good agreement with theoretical predictions for particle acceleration by turbulent waves generated by a violent collision. People Who Read This Also Read... Black Holes Have Simple Feeding Habits NASA’s Swift Satellite Catches First Supernova in The Act of Exploding Oldest Known Objects Are Surprisingly Immature Chandra Data Reveal Rapidly Whirling Black Holes In a broader astrophysical context, galaxy clusters are the largest gravitationally bound systems in the Universe and their collisions are the most energetic events since the Big Bang. Says team leader Gianfranco Brunetti (Instituto di Radioastronomia, Bologna, Italy), "The A521 system provides evidence that turbulence acts as a source of particle acceleration

  5. The Project Serapis: High Resolution Seismic Imagingof The Campi Flegrei Caldera Structure

    NASA Astrophysics Data System (ADS)

    Zollo, A.; Virieux, J.; Capuano, P.; Chiarabba, C.; de Franco, R.; Makris, J.; Michelini, A.; Musacchio, G.; Serapis Group

    , Iannaccone Giovanni, La Rocca Mario, Saccorotti Gilberto, Cattaneo Marco, De Mar- tin Martina , Colasanti Gianfranco, Moretti Milena, Marcello Silvestri, Edoardo Gian- domenico, Raffaele Stefano, Graziano Boniolo, Maria Rosaria Tondi, Maistrello Mar- iano, Gomez Antonio, Piccareda Carlo, Paolo Di Bartolomeo, Marco Romanelli, So- phie Peyrat, Christophe Larroque, Claude Pambrun, Tony Monfret, Stephane Gaffet, Mark Noble, Sylvain Nguyen 2