Sample records for gillian ragsdell daune

  1. TRMM Flyby of Gillian on Mar. 23, 2014

    NASA Video Gallery

    On March 23 when the TRMM satellite passed over Gillian, it was at hurricane-force. TRMM revealed intense storms in a well-defined eye wall producing rain at a rate of over 100mm/3.9 inches per hou...

  2. TRMM Flyby of Gillian Mar. 14

    NASA Video Gallery

    On March 14, 2014 at 1 a.m. EDT this simulated 3-D flyby of the TRMM satellite showed rain falling at the rate of over 116 mm/4.5 inches per hour (red), and some storms were higher than 16.75 km/10...

  3. Detection and Evaluation of Early Breast Cancer via Magnetic Resonance Imaging: Studies of Mouse Models and Clinical Implementation

    DTIC Science & Technology


    1. Sanaz A. Jansen, Tatjana Paunesku, GayleWoloschak, Stefan Vogt, Suzanne Conzen, Gillian M . Newstead and Gregory S. Karczmar. Why do Ductal...3. Sanaz A. Jansen, Xiaobing Fan, Gregory Karczmar, Maryellen Giger, Hiroyuki Abe and Gillian M . Newstead. Are Kinetic Parameters Diagnostically...4. Sanaz A. Jansen, Gregory Karczmar, Akiko Shimauchi, Hiroyuki Abe and Gillian M . Newstead. Are Kinetic Parameters Related to Prognostic

  4. Emergencies in children's and young people's nursing Emergencies in children's and young people's nursing Edward Alan Glasper , Gillian McEwing and Jim Richardson (Eds) Oxford University Press £21.95 456pp 9780199547197 019954719X [Formula: see text].



    THIS IS an excellent book for anyone dealing with children and young adults in an emergency care environment. its subjects range from the principles of care and the management of critical events, to more common injuries and illnesses.

  5. Detection and Evaluation of Early Breast Cancer via Magnetic Resonance Imaging: Studies of Mouse Models and Clinical Implementation

    DTIC Science & Technology


    Hiroyuki Abe, Robert A. Schmidt, and Gillian M . Newstead. ”Differentiation between benign and malignant breast lesions detected by bilateral dynamic...Gregory S. Karczmar, Hiroyuki Abe, Robert A. Schmidt, Maryellen Giger and Gillian M . Newstead.”DCEMRI of breast lesions: Is kinetic analysis equally...93. 4. Sanaz A. Jansen, Akiko Shimacuhi, Lindsay Zak, Xiaobing Fan, Abbie M . Wood, Gregory Karczmar and Gillian M Newstead. ”Kinetic curves of

  6. Computer Graphics Research Laboratory Quarterly Progress Report Number 43

    DTIC Science & Technology


    method and incorporates a gradient method [ Reklaitis 83]. By combining the two meth- ods, Levenberg-Marquardt method tries to improve the convergence...Trans. Pat- tern Analysis and Machine Intelligence 13(7):715-729, July 1991. [ Reklaitis 83] Reklaitis , G. V., A. Ravindran, and K. M. Ragsdell

  7. Trade-Off Analysis vs. Constrained Optimization with an Economic Control Chart Model

    DTIC Science & Technology


    description of this technique can be found in Luenberger (1989) or Reklaitis et al. (1983). Similar to the economic statistical designs, the trade-off...15] Reklaitis , G. V.; Ravindran, A.; and Ragsdell, K. M., Engineering Optimization, Methods and Applications, John Wiley & Sons, New York (1983). [16

  8. Toka Boot/The Big Jam: Making Music in Rural East Timor

    ERIC Educational Resources Information Center

    Howell, Gillian; Dunphy, Kim


    This article discusses a community music project in rural East Timor. Australian musician Gillian Howell lived for three months in the isolated town of Lospalos as an Asialink artist-in-residence, where she worked with local community members and visiting Australian musicians to share music and ideas, and to communicate across cultures. Three…

  9. Technology for Transition and Postsecondary Success: Supporting Executive Function

    ERIC Educational Resources Information Center

    Hayes, Gillian; Hosaflook, Stephen


    This six-page (tri-fold) laminated reference guide by Gillian Hayes and Stephen Hosaflook focuses on readily available tools for augmenting and supporting the development of executive function skills, such as time and task management, organization, and self-regulation. These skills are crucial for accomplishing a variety of transition-related…

  10. Oxbridge Redivivus

    ERIC Educational Resources Information Center

    Ainley, Patrick


    How the dominance of the two medieval universities, namely, (1) The University of Oxford; and (2) The University of Cambridge, was gained and maintained is the subject of the institutional histories by Gillian Evans. She has long been a thorn in the side of successive Cambridge Vice-Chancellors' aspirations to turn that institution--at which she…

  11. Making the Difference. Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia Incorporated (22nd, Adelaide, South Australia, July 4-7, 1999).

    ERIC Educational Resources Information Center

    Truran, John M., Ed.; Truran, Kathleen M., Ed.

    Papers from the 22nd Annual Conference of the Mathematics Education Research Group of Australasia Incorporated include the following: (1) "Making Sense of Primary Mathematics" (Gillian M. Boulton-Lewis); (2) "Seeking a Rationale for Particular Classroom Tasks and Activity" (Peter Sullivan); (3) "Research in Mathematics…

  12. Adult Learning: A Reader.

    ERIC Educational Resources Information Center

    Sutherland, Peter, Ed.

    This book on adult learning is divided into six sections. Section 1, Cognitive Processes, includes the following chapters: "Cognitive Processes: Contemporary Paradigms of Learning" (Jack Mezirow); "Information Processing, Memory, Age and Adult Learning" (Gillian Boulton-Lewis); "Adult Learners' Metacognitive Behaviour in Higher Education" (Barry…

  13. Research About Nineteenth-Century Children and Books. Portrait Studies.

    ERIC Educational Resources Information Center

    Richardson, Selma K., Ed.

    This collection of papers delivered at a symposium held in April 1979 explores the relationship between children and literature in the nineteenth century. The following titles are included: "The Researcher's Craft: Designs and Implements," and "Children's Books and Social History," by Gillian Avery; "Reflections on Histories of Childhood," by…

  14. The Language Testing Cycle: From Inception to Washback. Series S, Number 13.

    ERIC Educational Resources Information Center

    Wigglesworth, Gillian, Ed.; Elder, Catherine, Ed.

    A selection of essays on language testing includes: "Perspectives on the Testing Cycle: Setting the Scene" (Catherine Elder, Gillian Wigglesworth); "The Politicisation of English: The Case of the STEP Test and the Chinese Students" (Lesleyanne Hawthorne); "Developing Language Tests for Specific Populations" (Rosemary…

  15. Focus on the Teacher. Communicative Approaches to Teacher Training. ELT Documents 110.

    ERIC Educational Resources Information Center

    British Council, London (England). English Language and Literature Div.

    A collection of papers on the training of English teachers includes: an introduction (Gillian Marsh); "The Use of Video in EFL Teacher Training" (Michael J. Wallace); "Designing a Micro-Teaching Programme in the Third World" (Donard Britten, Falla Sow); "Teacher Training at the Colchester English Study Centre" (Jonathan Seath); "The Training of…

  16. Change and Continuity in Applied Linguistics. Selected Papers from the Annual Meeting of the British Association for Applied Linguistics (Edinburgh, Scotland, September 1999). British Studies in Applied Linguistics 15.

    ERIC Educational Resources Information Center

    Trappes-Lomax, Hugh, Ed.

    The following articles appear in this issue: "Changing Views of Language in Applied Linguistics" (Gillian Brown); "Society, Education, and Language: The Last 2000 (and the next 20?) Years of Language Teaching" (Michael Stubbs); "The Secret Life of Grammar Translation" (Malcolm J. Bensen); "Changing Views of…


    EPA Science Inventory

    Denslow, Nancy D., Christopher J. Bowman, Gillian Robinson, H. Stephen Lee, Ronald J. Ferguson, Michael J. Hemmer and Leroy C. Folmar. 1999. Biomarkers of Endocrine Disruption at the mRNA Level. In: Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for ...

  18. Stochastic Control Theory, Nonlinear Structural Mechanics and Applied Combinatorics

    DTIC Science & Technology


    facilities on the 5th floor of Vincent Hall. 8:30 am Dieter Jungnickel Nets and Groups Justus - Liebig University Abstract: We discuss (s, r, p) -nets and...25 Job, Vanessa University of Illinois, Chicago Jun 13 - 25 Jungnickel, D. Justus - Liebig University May 29 - Jun 24 Kacker, Raghu National Bureau...Jun 16 - 20 Nonay, Gillian Wilfred Laurier U., Canada Jun 19 - 26 Pott, Alexander Justus - Liebig University Jun 1 - 25 Pu, K. University of Illinois

  19. Pit and Fissure Sealants in Young Adults: An Evaluation of Placement Time and Retention Rate Using Two Isolation Techniques.

    DTIC Science & Technology


    L AD-A139 429 PI AND FSSJR SEAANTS IN YOUNG ADULTS AN EVAUAON I7 D-AUN L OFPLACEMENT ME.U) AIR FORCE INST OF TECHWRIOHT-PATTERSON AFB OH B A MATIS...I ll l l ....1 , , .. .. . ... i TABLE XIV Sealant retention by tooth surface at twelve months ........................ 44 TABLE XV Sealant...cotton - 12- roll isolation and the placement time of an occIusal amalgam restoration using rubber dam isolation in contralater.. l teeth. Fifty-five

  20. International Program and Local Organizing Committees

    NASA Astrophysics Data System (ADS)


    International Program Committee Dionisio Bermejo (Spain) Roman Ciurylo (Poland) Elisabeth Dalimier (France) Alexander Devdariani (Russia) Milan S Dimitrijevic (Serbia) Robert Gamache (USA) Marco A Gigosos (Spain) Motoshi Goto (Japan) Magnus Gustafsson (Sweden) Jean-Michel Hartmann (France) Carlos Iglesias (USA) John Kielkopf (USA) John C Lewis (Canada) Valery Lisitsa (Russia) Eugene Oks (USA) Christian G Parigger (USA) Gillian Peach (UK) Adriana Predoi-Cross (Canada) Roland Stamm (Germany) Local Organizing Committee Nikolay G Skvortsov (Chair, St Petersburg State University) Evgenii B Aleksandrov (Ioffe Physico-Technical Institute, St Petersburg) Vadim A Alekseev (Scientific Secretary, St Petersburg State University) Sergey F Boureiko (St.Petersburg State University) Yury N Gnedin (Pulkovo Observatory, St Petersburg) Alexander Z Devdariani (Deputy Chair, St Petersburg State University) Alexander P Kouzov (Deputy Chair, St Petersburg State University) Nikolay A Timofeev (St Petersburg State University)

  1. Composition and distribution of particulate matter (PM10) in a mechanically ventilated University building

    NASA Astrophysics Data System (ADS)

    Ali, Mohamed Yasreen Mohamed; Hanafiah, Marlia Mohd; Latif, Mohd Talib


    This study analyses the composition and distribution of particulate matter (PM10) in the Biology department building, in UKM. PM10 were collected using SENSIDYNE Gillian GilAir-5 Personal Air Sampling System, a low-volume sampler, whereas the concentration of heavy metals was determined using Inductively coupled plasma-mass spectrometry (ICP-MS). The concentration of PM10 recorded in the mechanically ventilated building ranges from 89 µgm-3 to 910 µgm-3. The composition of the selected heavy metals in PM10 were dominated by zinc, followed by copper, lead and cadmium. It was found that the present of indoor-related particulate matter were originated from the poorly maintained ventilation system, the activity of occupants and typical office equipments such as printers and photocopy machines. The haze event occured during sampling periods was also affected the PM10 concentration in the building. This results can serve as a starting point to assess the potential human health damage using the life cycle impact assessment, expressed in term of disability adjusted life year (DALY).

  2. Qualitative Evaluation of a Practice-based Experience Pilot Program for Master of Pharmacy Students in Scotland

    PubMed Central

    Hendry, Gillian; Winn, Philip; Wiggins, Sally


    Objective. To determine the views of pharmacists in central Scotland regarding experiential education for MPharm students. Methods. A thematic analysis was completed by Ms. Gillian Hendry and Dr. Sally Wiggins of interviews conducted with ten practicing pharmacists paired with first-year master of pharmacy (MPharm) students during the 2011-2012 academic year. Relevant comments from the interviews were manually sorted in a Microsoft Excel spreadsheet to bring similarly themed material together to facilitate the identification and naming of recurring themes and subthemes. Results. The pharmacists were unanimous in their opinion that experiential education was valuable for MPharm students and, in particular, that it helped students to develop self-confidence. The pharmacists derived personal satisfaction in developing mentor/mentee relationships with students. They also recognized the value that students provided to the workforce as well as the educational value to themselves in supervising students. The participants’ primary dissatisfaction was that the pharmacy workflow limited the time they could spend mentoring students. Conclusion. The results provide guidance to the academic community and the pharmacy practice community in the United Kingdom (UK) regarding the design and integration of experiential education courses in MPharm degree programs. PMID:28179714

  3. Chimpanzee (Pan troglodytes) relational matching: playing by their own (analogical) rules.


    Flemming, Timothy M; Kennedy, Erica Hoy


    Chimpanzees (Pan troglodytes) have been known to exhibit rudimentary abilities in analogical reasoning (Flemming, Beran, Thompson, Kleider, & Washburn, 2008; Gillian, Premack, & Woodruff, 1981; Haun & Call, 2009; Thompson & Oden, 2000; Thompson, Oden, & Boysen, 1997). With a wide array of individual differences, little can be concluded about the species' capacity for analogies, much less their strategies employed for solving such problems. In this study, we examined analogical strategies in 3 chimpanzees using a 3-dimensional search task (e.g., Kennedy & Fragaszy, 2008). Food items were hidden under 1 of 2 or 3 plastic cups of varying sizes. Subsequently, chimpanzees searched for food under the cup of the same relative size in their own set of cups--reasoning by analogy. Two chimpanzees initially appeared to fail the first relational phase of the task. Meta-analyses revealed, however, that they were instead using a secondary strategy not rewarded by the contingencies of the task--choosing on the basis of the same relative position in the sample. Although this was not the intended strategy of the task, it was nonetheless analogical. In subsequent phases of the task, chimpanzees eventually learned to shift their analogical reasoning strategy to match the reward contingencies of the task and successfully choose on the basis of relative size. This evidence not only provides support for the analogical ape hypothesis (Thompson & Oden, 2000), but also exemplifies how foundational conceptually mediated analogical behavior may be for the chimpanzee.



    Abbasi, Aziz-un-Nisa


    Zika virus (ZIKV) is an arbovirus belonging to flaviviridae family that includes Dengue, West Nile, and Yellow Fever among others. Zika virus was first discovered in 1947 in Zika forest of Uganda. It is a vector borne disease, which has been sporadically reported mostly from Africa, Pacific islands and Southeast Asia since its discovery. ZIKV infection presents as a mild illness with symptoms lasting for several days to a week after the bite of an infected mosquito. Majority of the patients have low grade fever, rash, headaches, joints pain, myalgia, and flu like symptoms. Pregnant women are more vulnerable to ZIKV infection and serious congenital anomalies can occur in foetus through trans-placental transmission. The gestation at which infection is acquired is important. Zika virus infection acquired in early pregnancy poses greater risk. There is no evidence so far about transmission through breast milk. Foetal microcephaly, Gillian Barre syndrome and other neurological and autoimmune syndromes have been reported in areas where Zika outbreaks have occurred. As infection is usually very mild no specific treatment is required. Pregnant women may be advised to take rest, get plenty of fluids. For fever and pain they can take antipyretics like paracetamol. So far no specific drugs or vaccines are available against Zika Virus Infection so prevention is the mainstay against this diseases. As ZIKV infection is a vector borne disease, prevention can be a multi-pronged strategy. These entail vector control interventions, personal protection, environmental sanitation and health education among others.

  5. Distinct Fos-Expressing Neuronal Ensembles in the Ventromedial Prefrontal Cortex Mediate Food Reward and Extinction Memories

    PubMed Central

    Warren, Brandon L.; Mendoza, Michael P.; Cruz, Fabio C.; Leao, Rodrigo M.; Caprioli, Daniele; Rubio, F. Javier; Whitaker, Leslie R.; McPherson, Kylie B.; Bossert, Jennifer M.; Shaham, Yavin


    In operant learning, initial reward-associated memories are thought to be distinct from subsequent extinction-associated memories. Memories formed during operant learning are thought to be stored in “neuronal ensembles.” Thus, we hypothesize that different neuronal ensembles encode reward- and extinction-associated memories. Here, we examined prefrontal cortex neuronal ensembles involved in the recall of reward and extinction memories of food self-administration. We first trained rats to lever press for palatable food pellets for 7 d (1 h/d) and then exposed them to 0, 2, or 7 daily extinction sessions in which lever presses were not reinforced. Twenty-four hours after the last training or extinction session, we exposed the rats to either a short 15 min extinction test session or left them in their homecage (a control condition). We found maximal Fos (a neuronal activity marker) immunoreactivity in the ventral medial prefrontal cortex of rats that previously received 2 extinction sessions, suggesting that neuronal ensembles in this area encode extinction memories. We then used the Daun02 inactivation procedure to selectively disrupt ventral medial prefrontal cortex neuronal ensembles that were activated during the 15 min extinction session following 0 (no extinction) or 2 prior extinction sessions to determine the effects of inactivating the putative food reward and extinction ensembles, respectively, on subsequent nonreinforced food seeking 2 d later. Inactivation of the food reward ensembles decreased food seeking, whereas inactivation of the extinction ensembles increased food seeking. Our results indicate that distinct neuronal ensembles encoding operant reward and extinction memories intermingle within the same cortical area. SIGNIFICANCE STATEMENT A current popular hypothesis is that neuronal ensembles in different prefrontal cortex areas control reward-associated versus extinction-associated memories: the dorsal medial prefrontal cortex (mPFC) promotes

  6. Role of Central Amygdala Neuronal Ensembles in Incubation of Nicotine Craving

    PubMed Central

    Coen, Kathleen; Tamadon, Sahar; Hope, Bruce T.; Shaham, Yavin; Lê, A.D.


    The craving response to smoking-associated cues in humans or to intravenous nicotine-associated cues in adult rats progressively increases or incubates after withdrawal. Here, we further characterized incubation of nicotine craving in the rat model by determining whether this incubation is observed after adolescent-onset nicotine self-administration. We also used the neuronal activity marker Fos and the Daun02 chemogenetic inactivation procedure to identify cue-activated neuronal ensembles that mediate incubation of nicotine craving. We trained adolescent and adult male rats to self-administer nicotine (2 h/d for 12 d) and assessed cue-induced nicotine seeking in extinction tests (1 h) after 1, 7, 14, or 28 withdrawal days. In both adult and adolescent rats, nicotine seeking in the relapse tests followed an inverted U-shaped curve, with maximal responding on withdrawal day 14. Independent of the withdrawal day, nicotine seeking in the relapse tests was higher in adult than in adolescent rats. Analysis of Fos expression in different brain areas of adolescent and adult rats on withdrawal days 1 and 14 showed time-dependent increases in the number of Fos-positive neurons in central and basolateral amygdala, orbitofrontal cortex, ventral and dorsal medial prefrontal cortex, and nucleus accumbens core and shell. In adult Fos–lacZ transgenic rats, selective inactivation of nicotine-cue-activated Fos neurons in central amygdala, but not orbitofrontal cortex, decreased “incubated” nicotine seeking on withdrawal day 14. Our results demonstrate that incubation of nicotine craving occurs after adolescent-onset nicotine self-administration and that neuronal ensembles in central amygdala play a critical role in this incubation. SIGNIFICANCE STATEMENT The craving response to smoking-associated cues in humans or to intravenous nicotine-associated cues in adult rats progressively increases or incubates after withdrawal. It is currently unknown whether incubation of craving

  7. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence

    PubMed Central

    de Guglielmo, Giordano; Crawford, Elena; Kim, Sarah; Vendruscolo, Leandro F.; Hope, Bruce T.; Brennan, Molly; Cole, Maury; Koob, George F.


    Abstinence from alcohol is associated with the recruitment of neurons in the central nucleus of the amygdala (CeA) in nondependent rats that binge drink alcohol and in alcohol-dependent rats. However, whether the recruitment of this neuronal ensemble in the CeA is causally related to excessive alcohol drinking or if it represents a consequence of excessive drinking remains unknown. We tested the hypothesis that the recruitment of a neuronal ensemble in the CeA during abstinence is required for excessive alcohol drinking in nondependent rats that binge drink alcohol and in alcohol-dependent rats. We found that inactivation of the CeA neuronal ensemble during abstinence significantly decreased alcohol drinking in both groups. In nondependent rats, the decrease in alcohol intake was transient and returned to normal the day after the injection. In dependent rats, inactivation of the neuronal ensemble with Daun02 produced a long-term decrease in alcohol drinking. Moreover, we observed a significant reduction of somatic withdrawal signs in dependent animals that were injected with Daun02 in the CeA. These results indicate that the recruitment of a neuronal ensemble in the CeA during abstinence from alcohol is causally related to excessive alcohol drinking in alcohol-dependent rats, whereas a similar neuronal ensemble only partially contributed to alcohol-binge-like drinking in nondependent rats. These results identify a critical neurobiological mechanism that may be required for the transition to alcohol dependence, suggesting that focusing on the neuronal ensemble in the CeA may lead to a better understanding of the etiology of alcohol use disorders and improve medication development. SIGNIFICANCE STATEMENT Alcohol dependence recruits neurons in the central nucleus of the amygdala (CeA). Here, we found that inactivation of a specific dependence-induced neuronal ensemble in the CeA reversed excessive alcohol drinking and somatic signs of alcohol dependence in rats. These

  8. Authenticity: is it real or is it marketing?


    Weinberger, David


    Marty Echt, the new head of marketing at Hunsk Engines, is determined to bring the motorcycle maker back to its roots. He says it's not enough to project authenticity to customers--employees must personally subscribe to the brand's values. Should the company's CEO support Marty's "real deal" vision? Five experts comment on this fictional case study. Bruce Weindruch, the founder and CEO of the History Factory, says that an authenticity-based campaign can be effective--but only if it's truly drawn from history. Marketers like Marty often remember their organization's past in a golden haze. Weindruch recommends exploring old engineering drawings, ads, and product photos in order to understand what customers and employees really valued back in the day. Gillian Arnold, a consultant to luxury fashion and fine jewelry brands, thinks Marty's approach is right: People in key marketing posts must be passionate about their products and know them inside and out. She argues that the CEO needs to commit more fully to the new campaign and address the significant gap between the staff and the brand. James H. Gilmore and B. Joseph Pine II, the cofounders of Strategic Horizons, point out that Hunsk needs to manage customers' perceptions rather than trying to be a "real company" or forming a management team whose personal interests match the brand. People purchase a product if it conforms to their self-image; that alone determines the brand's authenticity. Glenn Brackett of Sweetgrass Rods, a maker of bamboo fly-fishing rods, says Marty seems to be one of the few people who understand Hunsk motorcycles. If employees bring blood, sweat, heart, and soul to a product, it will manifest that spirit, and customers will line up for it.

  9. Artificial hydration and alimentation at the end of life: a reply to Craig.


    Ashby, M; Stoffell, B


    Dr Gillian Craig (1) has argued that palliative medicine services have tended to adopt a policy of sedation without hydration, which under certain circumstances may be medically inappropriate, causative of death and distressing to family and friends. We welcome this opportunity to defend, with an important modification, the approach we proposed without substantive background argument in our original article (2). We maintain that slowing and eventual cessation of oral intake is a normal part of a natural dying process, that artificial hydration and alimentation (AHA) are not justified unless thirst or hunger are present and cannot be relieved by other means, but food and fluids for (natural) oral consumption should never be 'withdrawn'. The intention of this practice is not to alter the timing of an inevitable death, and sedation is not used, as has been alleged, to mask the effects of dehydration or starvation. The artificial provision of hydration and alimentation is now widely accepted as medical treatment. We believe that arguments that it is not have led to confusion as to whether or not non-provision or withdrawal of AHA constitutes a cause of death in law. Arguments that it is such a cause appear to be tenuously based on an extraordinary/ordinary categorisation of treatments by Kelly (3) which has subsequently been interpreted as prescriptive in a way quite inconsistent with the Catholic moral theological tradition from which the distinction is derived. The focus of ethical discourse on decisions at the end of life should be shifted to an analysis of care, needs, proportionality of medical interventions, and processes of communication.

  10. Methamphetamine and Ovarian Steroid Responsive Cells in the Posteriodorsal Medial Amygdala are Required for Methamphetamine-enhanced Proceptive Behaviors

    PubMed Central

    Williams, Katrina M.; Mong, Jessica A.


    Methamphetamine (Meth) is a psychomotor stimulant strongly associated with increases in sexual drive and impulse in both men and women. These changes in sexual motivation have a greater impact on women due to their likelihood of facing the greater burden of unplanned pregnancies, as well as increased risk for psychiatric co-morbidities such as depression. We have previously established a rodent model of Meth-induced increases in sexual motivation. Using this model, we have identified the posteriodorsal medial amygdala (MePD) via excitotoxic lesion studies as a necessary nucleus in Meth-facilitated female sexual motivation. While lesion studies give us insight into key nuclei that may be targets of Meth action, such an approach does not give insight into the identity of the specific MePD neurons or neural circuitry involved in Meth-induced increases in proceptive behaviors. Using the DAUN02 inactivation method, a recently established technique for removing behaviorally relevant cell populations, we present evidence that the ovarian steroid/Meth responsive cells in the MePD are necessary for Meth-induced facilitation of proceptive behaviors. These findings form the basis for future work that will allow for the classification of neuronal subtypes involved in the MePD’s modulation of proceptive behavior as well as a stronger understanding of the neurocircuitry of female sexual motivation. PMID:28045134

  11. Comparison of volatile constituents of Persicaria odorata(Lour.) Soják (Polygonum odoratum Lour.) and Persicaria hydropiper L. Spach (Polygonum hydropiper L.).


    Starkenmann, Christian; Luca, Ludmila; Niclass, Yvan; Praz, Eric; Roguet, Didier


    Polygonum odoratum Lour. has been reclassified as Persicaria odorata (Lour.) Soják [Wilson, K. L. Polygonum sensu lato (Polygonaceae) in Australia. Telopea 1988, 3, 177-182]; other synonyms currently used are Vietnamese mint or Vietnamese coriander and, in Malaysia, Daun Laksa or Laksa plant. The aerial parts of Laksa plant are highly aromatic, and they contain many organic compounds such as (Z)-3-hexenal, (Z)-3-hexenol, decanal, undecanal, and dodecanal that are typical for green, citrus, orange peel, and coriander odors. In addition to these aldehydes, 3-sulfanyl-hexanal and 3-sulfanyl-hexan-1-ol were discovered for the first time in this herb. The fresh leaves are pungent when they are chewed, although the active compound has never been identified. The pungency of Persicaria hydropiper (L.) Spach (formerly Polygonum hydropiper L., synonym water pepper) is produced by polygodial, a 1,4-dialdehyde derived from drimane terpenoids. We also identified polygodial as the active pungent compound in P. odorata (Lour.) Soják.

  12. Application of a combination of dating techniques to reconstruct the Lateglacial and early Holocene landscape history of the Albula region (eastern Switzerland)

    NASA Astrophysics Data System (ADS)

    Böhlert, Ralph; Egli, Markus; Maisch, Max; Brandová, Dagmar; Ivy-Ochs, Susan; Kubik, Peter W.; Haeberli, Wilfried


    Landforms in Val Mulix and the Albula region in eastern Switzerland offer a detailed insight into the period between the Oldest Dryas until the early Holocene. To better understand Lateglacial and Holocene climate change in the central Alps, glacial (moraines, polished bedrock) and periglacial (rock glacier) landforms were dated using a combined approach of numerical (cosmogenic 10Be) and relative (Schmidt-hammer, weathering rind thickness) dating techniques. At high-elevation sites near the Last Glacial Maximum (LGM) trimline, 10Be exposure ages of glacially modified bedrock are between 11.2 ka and 13.5 ka. This suggests the persistence of long-lasting small local ice caps after the breakdown of the LGM ice domes or, alternatively, a reformation of ice perhaps during the Younger Dryas. In Val Mulix we obtained one of the first ages for the Daun-stadial (> 14.7 ka) moraines (14.9 ± 1.8 ka), supporting a pre-Bølling chronological position. The age is in excellent agreement with the age of a boulder from an Egesen I moraine located up-valley which we postulate may be a Daun moraine that was re-occupied during the Egesen stadial. A boulder from an Egesen II moraine gave an age of 10.7 ka, which is similar to ages of Egesen II moraines at other sites in the Alps. 10Be ages from boulders found on a relict rock glacier in Val Mulix indicate that the main active phase lasted from the Lateglacial until the early Holocene. The derived mean annual flow rate is of the order of decimetres, which is in accordance with values stated in the literature based on measuring active rock glaciers in the Alps. Exposure ages from a glacially polished rock barrier showed that this area was ice-free at the end of the Younger Dryas (9.0 ± 0.7 ka and 11.9 ± 0.9 ka). The polished bedrocks are located a few hundred meters down-valley from the Little Ice Age (LIA) moraines. This gives direct evidence of a fast ice retreat towards the end of the Younger Dryas, with glacier length variations

  13. Factors affecting commencement and cessation of smoking behaviour in Malaysian adults

    PubMed Central


    Background Tobacco consumption peak in developed countries has passed, however, it is on the increase in many developing countries. Apart from cigarettes, consumption of local hand-rolled cigarettes such as bidi and rokok daun are prevalent in specific communities. Although factors associated with smoking initiation and cessation has been investigated elsewhere, the only available data for Malaysia is on prevalence. This study aims to investigate factors associated with smoking initiation and cessation which is imperative in designing intervention programs. Methods Data were collected from 11,697 adults by trained recording clerks on sociodemographic characteristics, practice of other risk habit and details of smoking such as type, duration and frequency. Smoking commencement and cessation were analyzed using the Kaplan-Meier estimates and log-rank tests. Univariate and multivariate Cox proportional hazard regression models were used to calculate the hazard rate ratios. Results Males had a much higher prevalence of the habit (61.7%) as compared to females (5.8%). Cessation was found to be most common among the Chinese and those regularly consuming alcoholic beverages. Kaplan-Meier plot shows that although males are more likely to start smoking, females are found to be less likely to stop. History of betel quid chewing and alcohol consumption significantly increase the likelihood of commencement (p < 0.0001), while cessation was least likely among Indians, current quid chewers and kretek users (p < 0.01). Conclusions Gender, ethnicity, history of quid chewing and alcohol consumption have been found to be important factors in smoking commencement; while ethnicity, betel quid chewing and type of tobacco smoked influences cessation. PMID:22429627

  14. A network model comprising 4 segmental, interconnected ganglia, and its application to simulate multi-legged locomotion in crustaceans.


    Grabowska, M; Toth, T I; Smarandache-Wellmann, C; Daun-Gruhn, S


    Inter-segmental coordination is crucial for the locomotion of animals. Arthropods show high variability of leg numbers, from 6 in insects up to 750 legs in millipedes. Despite this fact, the anatomical and functional organization of their nervous systems show basic similarities. The main similarities are the segmental organization, and the way the function of the segmental units is coordinated. We set out to construct a model that could describe locomotion (walking) in animals with more than 6 legs, as well as in 6-legged animals (insects). To this end, we extended a network model by Daun-Gruhn and Tóth (Journal of Computational Neuroscience, doi: 10.1007/s10827-010-0300-1 , 2011). This model describes inter-segmental coordination of the ipsilateral legs in the stick insect during walking. Including an additional segment (local network) into the original model, we could simulate coordination patterns that occur in animals walking on eight legs (e.g., crayfish). We could improve the model by modifying its original cyclic connection topology. In all model variants, the phase relations between the afferent segmental excitatory sensory signals and the oscillatory activity of the segmental networks played a crucial role. Our results stress the importance of this sensory input on the generation of different stable coordination patterns. The simulations confirmed that using the modified connection topology, the flexibility of the model behaviour increased, meaning that changing a single phase parameter, i.e., gating properties of just one afferent sensory signal was sufficient to reproduce all coordination patterns seen in the experiments.

  15. Community perceptions on diarrheal diseases: a case study in swampy lowland area of south Sumatra, Indonesia. The Diarrheal Diseases Research and Training Study Group.


    Ismail, R; Aulia, H; Susanto, T A; Roisuddin; Hamzah, M


    Four investigators conducted participative observation at 4 hamlets, representing 4 typical topography in the area, wet or dry near the river and wet or dry far from the river, in District Rambutan, South Sumatera Province, Indonesia from July 1988 up until February 1989 to study the community perception and practices on diarrheal diseases (DD). The observation was supported by focus group discussions and informal interviews. It was found that the causes of DD can be grouped into: dirty water; wrong (cold, hot, sting) food; part of the growth process; physical condition (extreme heat, cold wind and inner abnormality, inner heat, muscle strain), and supernatural. The type of DD can be grouped into: mild without vomiting named ngadi, negenteng-ngentengi, nambah kepacakan, etc which was linked to the growth process; more severe diarrhea, might be with fever (mising-mising, murus, mencret, etc); more severe diarrhea with severe vomiting (muntager, kolera); bloody/mucoid stool (disentri, mising tai angin, mising umbal). The community had also the concept of prolonged diarrhea named as menerus (literally meaning prolonged) Muntaber was more associated with bad water while the prolonged one was more associated with inner abnormality. The danger of diarrhea perceived was susut = shrinkage, lisut = emaciation. Pale and red hair with lisut were recognized as the dangers of prolonged diarrhea. The community did not associate these conditions with fluid loss. The management started by self medication using tapel (pasta of herb applied) to the stomach), decoct (daun jambu, akar teratai etc), solid oral preparation (cassava with raw sugar, rast rice, etc).(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Piloted Well Clear Performance Evaluation of Detect and Avoid Systems with Suggestive Guidance

    NASA Technical Reports Server (NTRS)

    Mueller, Eric; Santiago, Confesor; Watza, Spencer


    Regulations to establish operational and performance requirements for unmanned aircraft systems (UAS) are being developed by a consortium of government, industry and academic institutions (RTCA, 2013). Those requirements will apply to the new detect-and-avoid (DAA) systems and other equipment necessary to integrate UAS with the United States (U.S) National Airspace System (NAS) and will be determined according to their contribution to the overall safety case. That safety case requires demonstration that DAA-equipped UAS collectively operating in the NAS meet an airspace safety threshold (AST). Several key gaps must be closed in order to link equipment requirements to an airspace safety case. Foremost among these is calculation of the systems risk ratio, the degree to which a particular system mitigates violation of an aircraft separation standard (FAA, 2013). The risk ratio of a DAA system, in combination with risk ratios of other collision mitigation mechanisms, will determine the overall safety of the airspace measured in terms of the number of collisions per flight hour. It is not known what the effectiveness is of a pilot-in-the-loop DAA system or even what parameters of the DAA system most improve the pilots ability to maintain separation. The relationship between the DAA system design and the overall effectiveness of the DAA system that includes the pilot, expressed as a risk ratio, must be determined before DAA operational and performance requirements can be finalized. Much research has been devoted to integrating UAS into non-segregated airspace (Dalamagkidis, 2009, Ostwald, 2007, Gillian, 2012, Hesselink, 2011, Santiago, 2015, Rorie 2015 and 2016). Several traffic displays intended for use as part of a DAA system have gone through human-in-the-loop simulation and flight-testing. Most of these evaluations were part of development programs to produce a deployable system, so it is unclear how to generalize particular aspects of those designs to general

  17. PREFACE: IUPAP C20 Conference on Computational Physics (CCP 2011)

    NASA Astrophysics Data System (ADS)

    Troparevsky, Claudia; Stocks, George Malcolm


    . We are grateful to the committees that helped put the conference together, especially the local organizing committee. Particular thanks are also due to a number of ORNL staff who spent long hours with the administrative details. We are pleased to express our thanks to the conference administrator Ann Strange (ORNL/CDP) for her responsive and efficient day-to-day handling of this event, Sherry Samples, Assistant Conference Administrator (ORNL), Angie Beach and the ORNL Conference Office, and Shirley Shugart (ORNL) and Fern Stooksbury (ORNL) who created and maintained the conference website. Editors: G Malcolm Stocks (ORNL) and M Claudia Troparevsky (UT) Chair: Dr Malcolm Stocks (ORNL) Vice Chairs: Adriana Moreo (ORNL/UT) James Guberrnatis (LANL) Local Program Committee: Don Batchelor (ORNL) Jack Dongarra (UTK/ORNL) James Hack (ORNL) Robert Harrison (ORNL) Paul Kent (ORNL) Anthony Mezzacappa (ORNL) Adriana Moreo (ORNL) Witold Nazarewicz (UT) Loukas Petridis (ORNL) David Schultz (ORNL) Bill Shelton (ORNL) Claudia Troparevsky (ORNL) Mina Yoon (ORNL) International Advisory Board Members: Joan Adler (Israel Institute of Technology, Israel) Constantia Alexandrou (University of Cyprus, Cyprus) Claudia Ambrosch-Draxl (University of Leoben, Austria) Amanda Barnard (CSIRO, Australia) Peter Borcherds (University of Birmingham, UK) Klaus Cappelle (UFABC, Brazil) Giovanni Ciccotti (Università degli Studi di Roma 'La Sapienza', Italy) Nithaya Chetty (University of Pretoria, South Africa) Charlotte Froese-Fischer (NIST, US) Giulia A. Galli (University of California, Davis, US) Gillian Gehring (University of Sheffield, UK) Guang-Yu Guo (National Taiwan University, Taiwan) Sharon Hammes-Schiffer (Penn State, US) Alex Hansen (Norweigan UST) Duane D. Johnson (University of Illinois at Urbana-Champaign, US) David Landau (University of Georgia, US) Joaquin Marro (University of Granada, Spain) Richard Martin (UIUC, US) Todd Martinez (Stanford University, US) Bill

  18. Holocene flood stack from three Eifel maar lakes

    NASA Astrophysics Data System (ADS)

    Brunck, Heiko; Sirocko, Frank


    Lacustrine sediments are very sensitive to natural and anthropogenically enviromental changes. Thus, lake sediments are excellent climate archives and can be used for reconstructions of past precipitation and flood events. However, we extend our flood record for MIS 2/3 to the entire Holocene up to recent years to get a complete flood stack for the last 60 000 years. The present study reconstructs paleo floods from event layers in the sediment, of Schalkenmehren Maar (SM3), Ulmen Maar (UM1) and Holzmaar (HM1) combined with recent gauge time-series. All three maar lakes has an inflow by a local stream. Accordingly the sedimentation rate is directly linked to runoff activity and the bioturbation was low so that event layers become visible, but varves are only preserved in lake Holzmaar. The maar sites are situated in the Eifel near to the town of Daun and were drilled in the ELSA (Eifel Laminated Sediment archive) project. The Eifel area is well suited to approximate Central European weather, because modern water level gauge data from Eifel rivers correlate with respective data from the Rhine (Wernli and Pfahl, 2009). Combined sedimentological, paleobotanical and geochemical data received from SM3, UM1 and HM1 builds the foundation of the 14C based chronology. The synchronisation of the record is controlled by tephra time markers and pollen. Both are used to align the main cores of the ELSA project and construct an integrated age model for the last 220 000 years [b2k] (Förster and Sirocko, 2014). For the extension of our MIS 2/3 flood stack we used the Laacher See Tephra (10 900 BC) as marker for the correlation with the Holocene cores. To study the flood events in detail, 10 cm long thin sections were used to distinguish flood layers from distal turbidites. Turbidites have a continuous grain size gradation; the grains size profile of flood events is in contrast characterized by several grain size maxima over the entire layer thickness. A flood event over several

  19. Engelhauptite, KCu3(V2O7)(OH)2Cl, a new mineral species from Eifel, Germany

    NASA Astrophysics Data System (ADS)

    Pekov, Igor V.; Siidra, Oleg I.; Chukanov, Nikita V.; Yapaskurt, Vasiliy O.; Britvin, Sergey N.; Krivovichev, Sergey V.; Schüller, Willi; Ternes, Bernd


    A new mineral engelhauptite, KCu3(V2O7)(OH)2Cl, was found within cavities in nepheline basalts at the Auf'm Kopp quarry ("Schlackenkegel der Höhe 636 südöstlich Neroth" ), Daun, Eifel region, Rheinland-Pfalz, Germany. Associated minerals are volborthite, allophane, malachite, tangeite and chrysocolla; earlier minerals belonging to the primary, high-temperature parageneses are augite, mica of the phlogopite-oxyphlogopite series, sanidine, nepheline, leucite, fluorapatite and magnetite. Engelhauptite occurs as spherulites (up to 0.2 mm in diameter) and bunches consisting of rough spindle-shaped crystals elongated parallel to [0001]. The crystals are up to 0.12 mm long and up to 0.04 mm thick. Individual grains of engelhauptite are transparent, whereas their aggregates are translucent. The mineral is yellow-brown to brown, typically with an olive green hue. The luster is vitreous. Engelhauptite is brittle, cleavage is not observed, fracture is uneven. D calc = 3.86 g cm-3. Engelhauptite is optically uniaxial (+), ω = 1.978(4), ɛ = 2.021(4). Chemical data (wt.%, electron-microprobe, H2O by difference) are as following: K2O 9.63, FeO 0.05, NiO 0.29, CuO 46.11, Al2O3 0.24, V2O5 34.92, SO3 0.79, Cl 5.94, H2Ocalc 3.37, O = Cl2 -1.34, total 100.00. The empirical formula, based on 10 (O + OH + Cl) apfu, is K1.05(Cu2.97Al0.02Ni0.02)Σ3.01(V1.97S0.05)Σ2.02O7.23(OH)1.91Cl0.86. Engelhauptite is hexagonal, P63/ mmc, a = 5.922(2), c = 14.513(5) Å, V = 440.78(3) Å3 and Z = 2. The eight strongest reflections of the powder X-ray diffraction pattern [ d,Å( I) ( hkl)] are: 7.32(98) (002), 4.224(17) (102), 2.979(100) (104, 110), 2.759(19) (112), 2.565(18) (200), 2.424(18) (202), 1.765(16) (206) and 1.481(14) (208, 220). The crystal structure of engelhauptite has been solved from the single-crystal X-ray diffraction data and refined to R = 0.090 on the basis of 135 unique observed reflections. The structure is based upon the [Cu2+ 3(V2O7)(OH)2]0 framework formed by the linkage

  20. Quality in university physics teaching: is it being achieved?

    NASA Astrophysics Data System (ADS)


    This was the title of a Physics Discipline Workshop held at the University of Leeds on 10 and 11 September 1998. Organizer Ashley Clarke of the university's Physics and Astronomy Department collected together an interesting variety of speakers polygonically targeting the topic, although as workshops go the audience didn't have to do much work except listen. There were representatives from 27 university physics departments who must have gone away with a lot to think about and possibly some new academic year resolutions to keep. But as a non-university no-longer teacher of (school) physics I was impressed with the general commitment to the idea that if you get the right quality of learning the teaching must be OK. I also learned (but have since forgotten) a lot of new acronyms. The keynote talk was by Gillian Hayes, Associate Director of the Quality Assurance Agency for Higher Education (QAA). She explained the role and implementation of the Subject Reviews that QAA is making for all subjects in all institutions of higher education on a five- to seven-year cycle. Physics Education hopes to publish an article about all this from QAA shortly. In the meantime, suffice it to say that the review looks at six aspects of provision, essentially from the point of view of enhancing students' experiences and learning. No doubt all participants would agree with this (they'd better if they want to score well on the Review) but may have been more worried by the next QAA speaker, Norman Jackson, who drummed in the basic facts of life as HE moves from an elite provision system to a mass provision system. He had an interesting graph showing how in the last ten years or so more students were getting firsts and upper seconds and fewer getting thirds. It seems that all those A-level students getting better grades than they used to are carrying on their good luck to degree level. But they still can't do maths (allegedly) and I doubt whether Jon Ogborn (IoP Advancing Physics Project

  1. PREFACE 12th International Workshop on Slow Positron Beam Techniques

    NASA Astrophysics Data System (ADS)

    Buckman, Stephen; Sullivan, James; White, Ronald


    SLOPOS-12 included: Positron Interactions with Surfaces Positron Beam and Detector Technology Positron Interactions with Atoms and Molecules Positronium Science Defects and Vacancies in Materials Porosity and Open Volume in Materials Antimatter in Biomedical Science Anti-hydrogen Studies Positron Transport Annihilation On a sad note, delegates paid tribute to the contributions of one of our colleagues, Chris Beling, who tragically passed away shortly before the meeting. Chris' contributions to positron science and to the education of young scientists were noted in a number of the invited presentations. It is an honour for our community to begin these proceedings with a short tribute to Chris' life by Professor Paul Coleman. The Workshop could not have occurred without the generous support of our sponsors: The ARC Centre for Antimatter-Matter Studies, The Australian National University, Flinders University, James Cook University, The Institute of Physics (UK) and the Australian Government's Department of Innovation, Industry, Science and Research. It would also not have been possible without the hard work of the Local and International Organising Committees and the friendly and efficient staff at the All Seasons Resort, Magnetic Island. We are most grateful for the on-site assistance of Gillian Drew, the CAMS student and postdoc team, the financial wizardry of Chris Kalos, and the post-Workshop editorial assistance of Julia Wee and Adam Edwards. Finally we would like to thank all of the attendees at SLOPOS12 for their scientific contributions to the Workshop, and for the warm spirit of engagement which characterised the scientific discussions and social occasions. SLOPOS13 will be held in Germany in 2013 and we all look forward to the occasion. Stephen Buckman, James Sullivan and Ronald White(Guest Editors) Local Organising CommitteeInternational Committee Stephen Buckman (Chair, ANU, Canberra)G Amarendra (India) James Sullivan (Secretary, ANU, Canberra)M-F Barthe (France

  2. Beitraege zur Astronomiegeschichte, Band 5 (Acta Historica Astronomiae Vol. 18)

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Dick, W. R.; Hamel, J.


    spectra in 1836. The authors quote details from the observing book and present some sketches (whose reproduction is somewhat poor, and the reader is referred to Häfner's history of Munich Observatory, discussed elsewhere in this volume of JAD, to see a better colour reproduction of a spectral sketch of Lamont). The impact of these studies (or rather the lack of it) is also briefly reviewed. Manfred Strumpf (Gotha) describes the difficulties in finding suitable directors for the Gotha Observatory - when the funds became smaller and the post thus became less and less attractive. Only the wealthy Nikolaus von Konkoly, a serious amateur and pioneer of astrophysics, applied even twice, but the administration was reluctant to seriously consider his offer. The result was that the chosen candidates were mainstream astronomers who used Gotha only as a step to foster their career and to find a better position as soon as possible. Finally, Peter Brosche (Daun) and Endre Zsoldos (Budapest) trace the life of a hitherto elusive craftsman-scientist, Friedrich Schwab. He was chosen to be the mechanic of one of the Venus transit expeditions of the German Empire (1882 to Punta Arenas), became university mechanic in Klausenburg, and later teacher at the technical school in Ilmenau. He was an active observer of variable stars and also a specialist in endomological studies. The authors have located a grand-son and have put to light some valuable notes and photographs. As can be seen from the summaries given above, this collection of essays deals mainly with historical events that occurred in Germany and neighboring countries, and focuses mainly on events in the 17th to 19th centuries. All contributions are written in German. The editors have taken care that generally a high standard was kept, although topic and realization make some articles more pleasant to read than others.