Studies of EGRET sources with a novel image restoration technique

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tajima, Hiroyasu; Cohen-Tanugi, Johann; Kamae, Tuneyoshi

2007-07-12

We have developed an image restoration technique based on the Richardson-Lucy algorithm optimized for GLAST-LAT image analysis. Our algorithm is original since it utilizes the PSF (point spread function) that is calculated for each event. This is critical for EGRET and GLAST-LAT image analysis since the PSF depends on the energy and angle of incident gamma-rays and varies by more than one order of magnitude. EGRET and GLAST-LAT image analysis also faces Poisson noise due to low photon statistics. Our technique incorporates wavelet filtering to minimize noise effects. We present studies of EGRET sources using this novel image restoration techniquemore » for possible identification of extended gamma-ray sources.« less

Swift and GLAST Cooperative Efforts

NASA Technical Reports Server (NTRS)

Thompson, D. J.

2007-01-01

Because gamma-ray astrophysics depends in many ways on multiwavelength studies, the Gamma-ray Large Area Space Telescope (GLAST) instrument teams are eagerly anticipating coordinated observations with the Swift observatory. Swift and GLAST combined cover most of twelve orders of magnitude in the electromagnetic spectrum, offering numerous opportunities for cooperation. Three of the high-priority interests are: (1) gamma-ray burst studies; (2) broad-spectrum studies of blazars in both quiescent and flaring states; and (3) identification and detailed study of unidentified gamma-ray sources.

New Results on High Energy Cosmic Ray Electrons Observed with Fermi LAT and Their Implications on the Models of Pulsars

NASA Technical Reports Server (NTRS)

Moiseev, Alexander

2010-01-01

This viewgraph presentation describes, in detail, the Fermi Large Area Telescope (LAT) and GLAST Burst Monitor (GBM). Observations made from the June 11, 2008 launch and a discussion of observations made of high energy cosmic ray electrons is also presented.

The GLAST Education and Public Outreach Program

NASA Astrophysics Data System (ADS)

Plait, P.; Graves, T.; Silva, S.; Simonnet, A.; Spear, G.; Cominsky, L.

2004-12-01

The Gamma-Ray Large Area Space Telescope (GLAST), due to launch in 2007, is a NASA mission designed to observe gamma rays from the most energetic objects in the Universe. The NASA Education and Public Outreach (E/PO) Group at Sonoma State University is the lead institution for GLAST E/PO. Given the size of the mission itself, we have planned and are executing an ambitious outreach program, including 1) an educators guide with activities (and a beautiful poster) designed to bring the science of active galaxies into the classroom; 2) a series of classroom modules by TOPS Learning Systems, Inc. that uses the GLAST mission to teach logarithms, powers of ten, and the scale of the Universe; 3) a robotic telescope in Sonoma County, California to observe GLAST targets, aiding not only GLAST science but also teaching students how astronomers process astronomical data; 4) ten Educator Ambassadors: award-winning teachers who help the E/PO group develop, test, and disseminate educational products; 5) an interactive Virtual Visitor Center web site for the Stanford Linear Accelerator Center, featuring an interactive simulation of GLAST's main gamma ray detector, which is being built by the US Department of Energy, and institutions in Italy, Japan, France and Sweden; 6) a one-hour PBS NOVA television show about black holes; 7) an interactive web-based Space Mystery which teaches students about active galaxies; 8) a series of educator workshops across the country to train teachers how to use the GLAST products; 9) an educators guide based on the high-energy physics of supernovae; and 10) extensive assessment by external evaluators at WestEd. More educational materials and information about the GLAST E/PO program can be found at http://glast.sonoma.edu.

GLAST Science Across Wavelengths

NASA Astrophysics Data System (ADS)

Blandford, R. D.

2006-12-01

The GLAST satellites is almost guaranteed to revolutionize GeV gamma ray astronomy because of the great discoveries that are being made at hard X-ray energy by the Suzaku and Swift satellites and in the TeV range using the H.E.S.S. and Magic telescopes. Unidentified EGRET sources are likely to be identified and new and fainter sources will be found. Known classes of sources blazars, pulsars, gamma ray bursts, supernova remnants, binary X-ray sources and so on will be monitored in much greater detail. Finally, there is the need to limit or even detect dark matter through its annihilation signature. The science that will emerge from GLAST will be determined in large measure by the effort that is put into multiwavelength observing. This will require significant commitments of observing time for monitoring pulsar arrival times, measuring faint galaxy spectra, detecting GeV gamma rays gamma ray bursts and so on. In this talk I will attempt to summarize current thinking on the GLAST multi-wavelength observing program and propose some new approaches.

Exploring the High Energy Universe: GLAST Mission and Science

NASA Technical Reports Server (NTRS)

McEnery, Julie

2007-01-01

GLAST, the Gamma-Ray Large Area Space Telescope, is NASA's next-generation high-energy gamma-ray satellite scheduled for launch in Autumn 2007. GLAST will allow measurements of cosmic gamma-ray sources in the 10 MeV to 100 GeV energy band to be made with unprecedented sensitivity. Amongst its key scientific objectives are to understand particle acceleration in Active Galactic Nuclei, Pulsars and Supernovae Remnants, to provide high resolution measurements of unidentified gamma-ray sources, to study transient high energy emission from objects such as gamma-ray bursts, and to probe Dark Matter and the early Universe. Dr. McEnery will present an overview of the GLAST mission and its scientific goals.

Exploring the High Energy Universe: GLAST Mission and Science

NASA Technical Reports Server (NTRS)

McEnery, Julie

2007-01-01

GLAST, the Gamma-Ray Large Area Space Telescope, is NASA's next-generation high-energy gamma-ray satellite scheduled for launch in Autumn 2007. GLAST will allow measurements of cosmic gamma-ray sources in t he 10 MeV to 100 GeV energy band to be made with unprecedented sensi tivity. Amongst its key scientific objectives are to understand part icle acceleration in Active Galactic Nuclei, Pulsars and Supernovae Remnants, to provide high resolution measurements of unidentified ga mma-ray sources, to study transient high energy emission from objects such as gamma-ray bursts, and to probe Dark Matter and the early Uni verse. Dr. McEnery will present an overview of the GLAST mission and its scientific goals.

GLAST and Suzaku

NASA Technical Reports Server (NTRS)

Sambruna, Rita

2007-01-01

The upcoming years will see a formidable synergy of high-energy observatories for the study of extragalactic objects, especially AGN. In particular, the launch of GLAST will allow us coordinated monitoring of sources with Suzaku over a very large energy band, from medium X-rays to GeV energies. In this talk I will review the science issues that such a remarkable coverage will enable us to address.

Force Measurement on the GLAST Delta II Flight

NASA Technical Reports Server (NTRS)

Gordon, Scott; Kaufman, Daniel

2009-01-01

This viewgraph presentation reviews the interface force measurement at spacecraft separation of GLAST Delta II. The contents include: 1) Flight Force Measurement (FFM) Background; 2) Team Members; 3) GLAST Mission Overview; 4) Methodology Development; 5) Ground Test Validation; 6) Flight Data; 7) Coupled Loads Simulation (VCLA & Reconstruction); 8) Basedrive Simulation; 9) Findings; and 10) Summary and Conclusions.

The Use of HepRep in GLAST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perl, Joseph

2003-07-10

HepRep is a generic, hierarchical format for description of graphics representables that can be augmented by physics information and relational properties. It was developed for high energy physics event display applications and is especially suited to client/server or component frameworks. The GLAST experiment, an international effort led by NASA for a gamma-ray telescope to launch in 2006, chose HepRep to provide a flexible, extensible and maintainable framework for their event display without tying their users to any one graphics application. To support HepRep in their GUADI infrastructure, GLAST developed a HepRep filler and builder architecture. The architecture hides the detailsmore » of XML and CORBA in a set of base and helper classes allowing physics experts to focus on what data they want to represent. GLAST has two GAUDI services: HepRepSvc, which registers HepRep fillers in a global registry and allows the HepRep to be exported to XML, and CorbaSvc, which allows the HepRep to be published through a CORBA interface and which allows the client application to feed commands back to GAUDI (such as start next event, or run some GAUDI algorithm). GLAST's HepRep solution gives users a choice of client applications, WIRED (written in Java) or FRED (written in C++ and Ruby), and leaves them free to move to any future HepRep-compliant event display.« less

Studying the High Energy Gamma Ray Sky with Gamma Ray Large Area Space Telescope (GLAST)

NASA Technical Reports Server (NTRS)

Kamae, T.; Ohsugi, T.; Thompson, D. J.; Watanabe, K.

1998-01-01

Building on the success of the Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory, the Gamma Ray Large Area Space Telescope (GLAST) will make a major step in the study of such subjects as blazars, gamma Ray bursts, the search for dark matter, supernova remnants, pulsars, diffuse radiation, and unidentified high energy sources. The instrument will be built on new and mature detector technologies such as silicon strip detectors, low-power low-noise LSI, and a multilevel data acquisition system. GLAST is in the research and development phase, and one full tower (of 25 total) is now being built in collaborating institutes. The prototype tower will be tested thoroughly at Stanford Linear Accelerator Center (SLAC) in the fall of 1999.

Real-Time Visualization of Spacecraft Telemetry for the GLAST and LRO Missions

NASA Technical Reports Server (NTRS)

Stoneking, Eric T.; Shah, Neerav; Chai, Dean J.

2010-01-01

GlastCam and LROCam are closely-related tools developed at NASA Goddard Space Flight Center for real-time visualization of spacecraft telemetry, developed for the Gamma-Ray Large Area Space Telescope (GLAST) and Lunar Reconnaissance Orbiter (LRO) missions, respectively. Derived from a common simulation tool, they use related but different architectures to ingest real-time spacecraft telemetry and ground predicted ephemerides, and to compute and display features of special interest to each mission in its operational environment. We describe the architectures of GlastCam and LROCam, the customizations required to fit into the mission operations environment, and the features that were found to be especially useful in early operations for their respective missions. Both tools have a primary window depicting a three-dimensional Cam view of the spacecraft that may be freely manipulated by the user. The scene is augmented with fields of view, pointing constraints, and other features which enhance situational awareness. Each tool also has another "Map" window showing the spacecraft's groundtrack projected onto a map of the Earth or Moon, along with useful features such as the Sun, eclipse regions, and TDRS satellite locations. Additional windows support specialized checkout tasks. One such window shows the star tracker fields of view, with tracking window locations and the mission star catalog. This view was instrumental for GLAST in quickly resolving a star tracker mounting polarity issue; visualization made the 180-deg mismatch immediately obvious. Full access to GlastCam's source code also made possible a rapid coarse star tracker mounting calibration with some on the fly code adjustments; adding a fine grid to measure alignment offsets, and introducing a calibration quaternion which could be adjusted within GlastCam without perturbing the flight parameters. This calibration, from concept to completion, took less than half an hour. Both GlastCam and LROCam were

GlastCam: A Telemetry-Driven Spacecraft Visualization Tool

NASA Technical Reports Server (NTRS)

Stoneking, Eric T.; Tsai, Dean

2009-01-01

Developed for the GLAST project, which is now the Fermi Gamma-ray Space Telescope, GlastCam software ingests telemetry from the Integrated Test and Operations System (ITOS) and generates four graphical displays of geometric properties in real time, allowing visual assessment of the attitude, configuration, position, and various cross-checks. Four windows are displayed: a "cam" window shows a 3D view of the satellite; a second window shows the standard position plot of the satellite on a Mercator map of the Earth; a third window displays star tracker fields of view, showing which stars are visible from the spacecraft in order to verify star tracking; and the fourth window depicts

Apical localization of glutamate in GLAST-1, glutamine synthetase positive ciliary body nonpigmented epithelial cells

PubMed Central

Langford, Marlyn P; Gosslee, Jeffrey M; Liang, Chanping; Chen, Dequan; Redens, Thomas B.; Welbourne, Tomas C

2007-01-01

The distribution of glutamate (Glu), the Glu transporter GLAST-1, and glutamine synthetase (GS) in human and monkey anterior uveal tissue, as well as serum (S) to aqueous humor (AH) Glu and glutamine (Gln) gradients were investigated. Cross-linked Glu (xGlu), GLAST-1, and GS were detected using the immunofluorescent antibody technique. S/AH Glu, Gln, and alanine (Ala) concentrations were quantified by high performance liquid chromatography. xGlu immunoreactivity was detected in melanocytes, posterior pigmented epithelial/dilator muscle cells, vascular endothelial cells, and lymphocytes of the iris, as well as the pigmented (PE) and nonpigmented epithelial (NPE) cells and muscle cells of ciliary body. xGlu immunoreactivity was highly concentrated at the apices of GLAST-1, GS positive ciliary body NPE cells, and in GLAST-1 positive iris melanocytes and iris dilator muscle cells. AH Glu concentrations were lower (p < 0.001), while Gln was higher in monkey (p = 0.01) and human cataractous (p = 0.15) AH than serum. The results indicate that Glu is concentrated within GLAST-1, GS positive NPE cells and are consistent with the suggestion that Glu and Gln concentrations in AH may be due in part to GLAST-1 and GS activity in iris and ciliary body epithelial cells. PMID:19668465

Downregulation of Glutamine Synthetase via GLAST Suppression Induces Retinal Axonal Swelling in a Rat Ex Vivo Hydrostatic Pressure Model

PubMed Central

Yoshitomi, Takeshi; Zorumski, Charles F.; Izumi, Yukitoshi

2011-01-01

Purpose. High levels of glutamate can be toxic to retinal GCs. Thus, effective buffering of extracellular glutamate is important in preserving retinal structure and function. GLAST, a major glutamate transporter in the retina, and glutamine synthetase (GS) regulate extracellular glutamate accumulation and prevent excitotoxicity. This study was an examination of changes in function and expression of GLAST and GS in ex vivo rat retinas exposed to acute increases in ambient pressure. Methods. Ex vivo rat retinas were exposed to elevated hydrostatic pressure for 24 hours. The expression of GLAST and GS were examined using immunochemistry and real-time PCR analysis. Also examined were the effects of (2S,3S)-3-[3-[4-(trifluoromethyl) benzoylamino] benzyloxy] aspartate (TFB-TBOA), an inhibitor of glutamate transporters, and l-methionine-S-sulfoximine (MSO), an inhibitor of GS. Results. In this acute model, Western blot and real-time RT-PCR analyses revealed that substantially (75 mm Hg), but not moderately (35 mm Hg), elevated pressure depressed GLAST expression, diminished GS activity, and induced axonal swelling between the GC layer and the inner limiting membrane. However, at the moderately elevated pressure (35 mm Hg), administration of either TFB-TBOA or MSO also induced axonal swelling and excitotoxic neuronal damage. MSO did not depress GLAST expression but TFB-TBOA significantly suppressed GS, suggesting that downregulation of GS during pressure loading may result from impaired GLAST expression. Conclusions. The retina is at risk during acute intraocular pressure elevation due to downregulation of GS activity resulting from depressed GLAST expression. PMID:21775659

Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model.

PubMed

Ishikawa, Makoto; Yoshitomi, Takeshi; Zorumski, Charles F; Izumi, Yukitoshi

2011-08-22

PURPOSE. High levels of glutamate can be toxic to retinal GCs. Thus, effective buffering of extracellular glutamate is important in preserving retinal structure and function. GLAST, a major glutamate transporter in the retina, and glutamine synthetase (GS) regulate extracellular glutamate accumulation and prevent excitotoxicity. This study was an examination of changes in function and expression of GLAST and GS in ex vivo rat retinas exposed to acute increases in ambient pressure. METHODS. Ex vivo rat retinas were exposed to elevated hydrostatic pressure for 24 hours. The expression of GLAST and GS were examined using immunochemistry and real-time PCR analysis. Also examined were the effects of (2S,3S)-3-[3-[4-(trifluoromethyl) benzoylamino] benzyloxy] aspartate (TFB-TBOA), an inhibitor of glutamate transporters, and l-methionine-S-sulfoximine (MSO), an inhibitor of GS. RESULTS. In this acute model, Western blot and real-time RT-PCR analyses revealed that substantially (75 mm Hg), but not moderately (35 mm Hg), elevated pressure depressed GLAST expression, diminished GS activity, and induced axonal swelling between the GC layer and the inner limiting membrane. However, at the moderately elevated pressure (35 mm Hg), administration of either TFB-TBOA or MSO also induced axonal swelling and excitotoxic neuronal damage. MSO did not depress GLAST expression but TFB-TBOA significantly suppressed GS, suggesting that downregulation of GS during pressure loading may result from impaired GLAST expression. CONCLUSIONS. The retina is at risk during acute intraocular pressure elevation due to downregulation of GS activity resulting from depressed GLAST expression.

GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus

PubMed Central

Yu, Hong; Vikhe Patil, Kim; Han, Chul; Fabella, Brian; Canlon, Barbara; Someya, Shinichi; Cederroth, Christopher R.

2016-01-01

Gap detection or gap pre-pulse inhibition of the acoustic startle (GPIAS) has been successfully used in rat and guinea pig models of tinnitus, yet this system has been proven to have low efficacy in CBA mice, with low basal GPIAS and subtle tinnitus-like effects. Here, we tested five mouse strains (CBA, BalbC, CD-1, C57BL/6 and 129sv) for pre-pulse inhibition (PPI) and gap detection with varying interstimulus intervals (ISI) and found that mice from a CBA genetic background had the poorest capacities of suppressing the startle response in the presence of a pre-pulse or a gap. CD-1 mice displayed variable responses throughout all ISI. Interestingly, C57BL/6, 129sv and BalbC showed efficient suppression with either pre-pulses or gaps with shorter ISI. The glutamate aspartate transporter (GLAST) is expressed in support cells from the cochlea and buffers the excess of glutamate. We hypothesized that loss of GLAST function could sensitize the ear to tinnitus-inducing agents, such as salicylate. Using shorter ISI to obtain a greater dynamic range to assess tinnitus-like effects, we found that disruption of gap detection by salicylate was exacerbated across various intensities of a 32-kHz narrow band noise gap carrier in GLAST knockout (KO) mice when compared to their wild-type (WT) littermates. Auditory brainstem responses (ABR) and distortion-product otoacoustic emission (DPOAE) were performed to evaluate the effects on hearing functions. Salicylate caused greater auditory threshold shifts (near 15 dB) in GLAST KO mice than in WT mice across all tested frequencies, despite similarly reduced DPOAE. Despite these changes, inhibition using broad-band gap carriers and 32 kHz pre-pulses were not affected. Our study suggests that GLAST deficiency could become a useful experimental model to decipher the mechanisms underlying drug-induced tinnitus. Future studies addressing the neurological correlates of tinnitus in this model could provide additional insights into the

GLAST Deficiency in Mice Exacerbates Gap Detection Deficits in a Model of Salicylate-Induced Tinnitus.

PubMed

Yu, Hong; Vikhe Patil, Kim; Han, Chul; Fabella, Brian; Canlon, Barbara; Someya, Shinichi; Cederroth, Christopher R

2016-01-01

Gap detection or gap pre-pulse inhibition of the acoustic startle (GPIAS) has been successfully used in rat and guinea pig models of tinnitus, yet this system has been proven to have low efficacy in CBA mice, with low basal GPIAS and subtle tinnitus-like effects. Here, we tested five mouse strains (CBA, BalbC, CD-1, C57BL/6 and 129sv) for pre-pulse inhibition (PPI) and gap detection with varying interstimulus intervals (ISI) and found that mice from a CBA genetic background had the poorest capacities of suppressing the startle response in the presence of a pre-pulse or a gap. CD-1 mice displayed variable responses throughout all ISI. Interestingly, C57BL/6, 129sv and BalbC showed efficient suppression with either pre-pulses or gaps with shorter ISI. The glutamate aspartate transporter (GLAST) is expressed in support cells from the cochlea and buffers the excess of glutamate. We hypothesized that loss of GLAST function could sensitize the ear to tinnitus-inducing agents, such as salicylate. Using shorter ISI to obtain a greater dynamic range to assess tinnitus-like effects, we found that disruption of gap detection by salicylate was exacerbated across various intensities of a 32-kHz narrow band noise gap carrier in GLAST knockout (KO) mice when compared to their wild-type (WT) littermates. Auditory brainstem responses (ABR) and distortion-product otoacoustic emission (DPOAE) were performed to evaluate the effects on hearing functions. Salicylate caused greater auditory threshold shifts (near 15 dB) in GLAST KO mice than in WT mice across all tested frequencies, despite similarly reduced DPOAE. Despite these changes, inhibition using broad-band gap carriers and 32 kHz pre-pulses were not affected. Our study suggests that GLAST deficiency could become a useful experimental model to decipher the mechanisms underlying drug-induced tinnitus. Future studies addressing the neurological correlates of tinnitus in this model could provide additional insights into the

GLAST answers about high-energy peaked BL Lacs: double-humped {gamma}-ray peak and extreme accelerators?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costamante, L.; Aharonian, F.; Khangulyan, D.

2007-07-12

An often overlooked fact is that the MeV-GeV emission from High-energy peaked BL Lacs (HBL) is basically unknown: there are only 3 objects of this type among all EGRET identified blazars with measured spectra. GLAST will be able to measure the spectrum for many of them, in particular TeV-blazars, and surprises are expected. GLAST will tell if the {gamma}-ray peak in some HBL is actually a ''double peak'', as suggested by the comparison of EGRET and HESS data in PKS 2155-304, We also remind and argue that a new class of BL Lacs could exist, where particles are shock-accelerated nearmore » the maximum possible rate, characterized by the synchrotron emission peaking in the GLAST band (100 MeV - few GeV). Such objects could easily have escaped detection or identification so far, and could now be unveiled by GLAST.« less

Estimation of Electron Temperature on Glass Spherical Tokamak (GLAST)

NASA Astrophysics Data System (ADS)

Hussain, S.; Sadiq, M.; Shah, S. I. W.; GLAST Team

2015-03-01

Glass Spherical Tokamak (GLAST) is a small spherical tokamak indigenously developed in Pakistan with an insulating vacuum vessel. A commercially available 2.45 GHz magnetron is used as pre-ionization source for plasma current startup. Different diagnostic systems like Rogowski coils, magnetic probes, flux loops, Langmuir probe, fast imaging and emission spectroscopy are installed on the device. The plasma temperature inside of GLAST, at the time of maxima of plasma current, is estimated by taking into account the Spitzer resistivity calculations with some experimentally determined plasma parameters. The plasma resistance is calculated by using Ohm's law with plasma current and loop voltage as experimentally determined inputs. The plasma resistivity is then determined by using length and area of the plasma column. Finally, the average plasma electron temperature is predicted to be 12.65eV for taking neon (Ne) as a working gas.

Detecting the Attenuation of Blazar Gamma-ray Emission by Extragalactic Background Light with GLAST

NASA Technical Reports Server (NTRS)

Chen, Andrew; Ritz, Steven

1999-01-01

Gamma rays with energy above 10 GeV interact with optical-UV photons resulting in pair production. Therefore, a large sample of high redshift sources of these gamma rays can be used to probe the extragalactic background starlight (EBL) by examining the redshift dependence of the attenuation of the flux above 10 GeV. GLAST, the next generation high-energy gamma-ray telescope, will for the first time have the unique capability to detect thousands of gamma-ray blazars up to redshifts of at least z = 4, with enough angular resolution to allow identification of a large fraction of their optical counterparts. By combining recent determinations of the gamma-ray blazar luminosity function, recent calculations of the high energy gamma-ray opacity due to EBL absorption, and the expected GLAST instrument performance to produce simulated samples of blazars that GLAST would detect, including their redshifts and fluxes, we demonstrate that these blazars have the potential to be a highly effective probe of the EBL.

Future Facilities for Gamma-Ray Pulsar Studies

NASA Technical Reports Server (NTRS)

Thompson, D. J.

2003-01-01

Pulsars seen at gamma-ray energies offer insight into particle acceleration to very high energies, along with information about the geometry and interaction processes in the magnetospheres of these rotating neutron stars. During the next decade, a number of new gamma-ray facilities will become available for pulsar studies. This brief review describes the motivation for gamma-ray pulsar studies, the opportunities for such studies, and some specific discussion of the capabilities of the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT) for pulsar measurements.

Overexpression of L-Type Amino Acid Transporter 1 (LAT1) and 2 (LAT2): Novel Markers of Neuroendocrine Tumors

PubMed Central

Barollo, Susi; Bertazza, Loris; Watutantrige-Fernando, Sara; Censi, Simona; Cavedon, Elisabetta; Galuppini, Francesca; Pennelli, Gianmaria; Fassina, Ambrogio; Citton, Marilisa; Rubin, Beatrice; Pezzani, Raffaele; Benna, Clara; Opocher, Giuseppe; Iacobone, Maurizio; Mian, Caterina

2016-01-01

Background 6-18F-fluoro-L-3,4-dihydroxyphenylalanine (18F-FDOPA) PET is a useful tool in the clinical management of pheochromocytoma (PHEO) and medullary thyroid carcinoma (MTC). 18F-FDOPA is a large neutral amino acid biochemically resembling endogenous L-DOPA and taken up by the L-type amino acid transporters (LAT1 and LAT2). This study was conducted to examine the expression of the LAT system in PHEO and MTC. Methods Real-time PCR and Western blot analyses were used to assess LAT1 and LAT2 gene and protein expression in 32 PHEO, 38 MTC, 16 normal adrenal medulla and 15 normal thyroid tissue samples. Immunohistochemistry method was applied to identify the proteins’ subcellular localization. Results LAT1 and LAT2 were overexpressed in both PHEO and MTC by comparison with normal tissues. LAT1 presented a stronger induction than LAT2, and their greater expression was more evident in PHEO (15.1- and 4.1-fold increases, respectively) than in MTC (9.9- and 4.1-fold increases, respectively). Furthermore we found a good correlation between LAT1/2 and GLUT1 expression levels. A positive correlation was also found between urinary noradrenaline and adrenaline levels and LAT1 gene expression in PHEO. The increased expression of LAT1 is also confirmed at the protein level, in both PHEO and MTC, with a strong cytoplasmic localization. Conclusions The present study is the first to provide experimental evidence of the overexpression in some NET cancers (such as PHEO or MTC) of L-type amino acid transporters, and the LAT1 isoform in particular, giving the molecular basis to explain the increase of the DOPA uptake seen in such tumor cells. PMID:27224648

The Origin of Cosmic Rays: What can GLAST Say?

NASA Technical Reports Server (NTRS)

Ormes, Jonathan F.; Digel, Seith; Moskalenko, Igor V.; Moiseev, Alexander; Williamson, Roger

2000-01-01

Gamma rays in the band from 30 MeV to 300 GeV, used in combination with direct measurements and with data from radio and X-ray bands, provide a powerful tool for studying the origin of Galactic cosmic rays. Gamma-ray Large Area Space Telescope (GLAST) with its fine 10-20 arcmin angular resolution will be able to map the sites of acceleration of cosmic rays and their interactions with interstellar matter, It will provide information that is necessary to study the acceleration of energetic particles in supernova shocks, their transport in the interstellar medium and penetration into molecular clouds.

Simultaneous observation of the gamma-ray binary LS I+61 303 with GLAST and Suzaku

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tanaka, Takuya; Fukazawa, Yasushi; Mizuno, Tsunefumi

2007-07-12

The gamma-ray binary LS I+61 303 is a bright gamma-ray source, and thus an attracting object for GLAST. We proposed to observe this object with the X-ray satellite Suzaku (AO-2), simultaneously with GLAST, radio wave, and optical spectro-polarimetry, in order to probe the geometrical state of the binary system emitting the gamma-ray radiation, as a function of the binary orbital phase for the first time. This is essential to understand the mechanism of jet production and gamma-ray emission. The idea is not only to measure the multi-band overall continuum shape, but also to make use of continuous monitoring capability ofmore » GLAST, wide X-ray band of Suzaku, and good accessibility of the Kanata optical/NIR telescope (Hiroshima University) with the sensitive optical spectro-polarimetry. Further collaboration with TeV gamma-ray telescopes is also hoped to constrain the jet constitution.« less

Assessment of Glutamate Transporter GLAST (EAAT1)-Deficient Mice for Phenotypes Relevant to the Negative and Executive/Cognitive Symptoms of Schizophrenia

PubMed Central

Karlsson, Rose-Marie; Tanaka, Kohichi; Saksida, Lisa M; Bussey, Timothy J; Heilig, Markus; Holmes, Andrew

2012-01-01

Glutamatergic dysfunction is increasingly implicated in the pathophysiology of schizophrenia. Current models postulate that dysfunction of glutamate and its receptors underlie many of the symptoms in this disease. However, the mechanisms involved are not well understood. Although elucidating the role for glutamate transporters in the disease has been limited by the absence of pharmacological tools that selectively target the transporter, we recently showed that glial glutamate and aspartate transporter (GLAST; excitatory amino-acid transporter 1) mutant mice exhibit abnormalities on behavioral measures thought to model the positive symptoms of schizophrenia, some of which were rescued by treatment with either haloperidol or the mGlu2/3 agonist, LY379268 the mGlu2/3 agonist, LY379268. To further determine the role of GLAST in schizophrenia-related behaviors we tested GLAST mutant mice on a series of behavioral paradigms associated with the negative (social withdrawal, anhedonia), sensorimotor gating (prepulse inhibition of startle), and executive/cognitive (discrimination learning, extinction) symptoms of schizophrenia. GLAST knockout (KO) mice showed poor nesting behavior and abnormal sociability, whereas KO and heterozygous (HET) both demonstrated lesser preference for a novel social stimulus compared to wild-type littermate controls. GLAST KO, but not HET, had a significantly reduced acoustic startle response, but no significant deficit in prepulse inhibition of startle. GLAST KO and HET showed normal sucrose preference. In an instrumental visual discrimination task, KO showed impaired learning. By contrast, acquisition and extinction of a simple instrumental response was normal. The mGlu2/3 agonist, LY379268, failed to rescue the discrimination impairment in KO mice. These findings demonstrate that gene deletion of GLAST produces select phenotypic abnormalities related to the negative and cognitive symptoms of schizophrenia. PMID:19078949

Fourth Workshop on Science with the New Generation of High Energy Gamma-ray Experiments

NASA Astrophysics Data System (ADS)

Massai, Marco Maria; Omodei, Nicola; Spandre, Gloria

I. Space-based telescope. Integral-4 years in orbit / P. Umbertini, P. Caraveo. The Suzaku mission / K. Yamaoka. The Swift mission: two years of operation / A. Moretti. Gamma-ray astrophysics with AGILE / F.Longo et al., The AGILE collaboration. The GLAST mission / J.E. McEnery -- II. Ground-based telescope. Recent results from CANGAROO / M. Mori for the CANGAROO team. The H.E.S.S. project / C. Masterson for the H.E.S.S. collaboration. The MAGIC experiment / N. Turini for the MAGIC collaboration. VERITAS: status and performance / J. Holder for the VERITAS collaboration -- III. Galactic variable sources. Galactic variable sky with EGRET and GLAST / S. Digel. Galactic variable sources observed with H.E.S.S. / N. Komin for the H.E.S.S collaboration. Gamma ray pulsars in the GLAST era / M. Razzano. Solving the riddle of unidentified high-energy gamma-ray sources / P. Caraveo. Supernovae and gamma-ray burst / M. Della Valle. First cycle of MAGIC galactic observations / J. Cortina for the MAGIC collaboration. Gamma-rays and neutrinos from a SNR in the galactic center / V. Cavasinni, D. Grasso, L. Maccione. Solving GRBs and SGRs puzzles by precessing jets / D. Fargion, O. Lanciano, P. Oliva -- IV. Extragalactic sources. Multiwavelength observations and theories of blazers / G. Tosti. AGN observations with the MAGIC telescope / C. Bigongiari for the MAGIC collaboration. Gamma ray bursts/ L. Amati. X-rays and GeV flares in GRB light curves / A. Galli ... [et al.]. The highest energy emission from gamma ray bursts: MILAGRO's constraints and HAWC's potential / B. Dingus for the MILAGRO and HAWC collaborations. Observation of GRB with the MAGIC telescope / N. Galante, P. Piccioli for the MAGIC collaboration. GRB 060218 and the outliers with respect to the E-E correlation / G. Ghirlanda, G. Ghibellini -- V. Poster session. Study of the performance and calibration of the GLAST-LAT silicon tracker / M. Brigida, N. Giglietto, P. Spinelli. The online monitor for the GLAST

Activated PLC-γ1 is Catalytically Induced at LAT but Activated PLC-γ1 is Localized at both LAT- and TCR-Containing Complexes

PubMed Central

Cruz-Orcutt, Noemi; Vacaflores, Aldo; Connolly, Sean F.; Bunnell, Stephen C.; Houtman, Jon C.D.

2014-01-01

Phospholipase C-γ1 (PLC-γ1) is a key regulator of T cell receptor (TCR)-induced signaling. Activation of the TCR enhances PLC-γ1 enzymatic function, resulting in calcium influx and the activation of PKC family members and RasGRP. The current model is that phosphorylation of LAT tyrosine 132 facilitates the recruitment of PLC-γ1, leading to its activation and function at the LAT complex. In this study, we examined the phosphorylation kinetics of LAT and PLC-γ1 and the cellular localization of activated PLC-γ1. We observed that commencement of the phosphorylation of LAT tyrosine 132 and PLC-γ1 tyrosine 783 occurred simultaneously, supporting the current model. However, once begun, PLC-γ1 activation occurred more rapidly than LAT tyrosine 132. The association of LAT and PLC-γ1 was more transient than the interaction of LAT and Grb2 and a pool of activated PLC-γ1 translocated away from LAT to cellular structures containing the TCR. These studies demonstrate that LAT and PLC-γ1 form transient interactions that catalyze the activation of PLC-γ1, but that activated PLC-γ1 resides in both LAT and TCR clusters. Together, this work highlights that our current model is incomplete and the activation and function of PLC-γ1 in T cells is highly complex. PMID:24412752

Development of nanoscale structure in LAT-based signaling complexes

PubMed Central

2016-01-01

ABSTRACT The adapter molecule linker for activation of T cells (LAT) plays a crucial role in forming signaling complexes induced by stimulation of the T cell receptor (TCR). These multi-molecular complexes are dynamic structures that activate highly regulated signaling pathways. Previously, we have demonstrated nanoscale structure in LAT-based complexes where the adapter SLP-76 (also known as LCP2) localizes to the periphery of LAT clusters. In this study, we show that initially LAT and SLP-76 are randomly dispersed throughout the clusters that form upon TCR engagement. The segregation of LAT and SLP-76 develops near the end of the spreading process. The local concentration of LAT also increases at the same time. Both changes require TCR activation and an intact actin cytoskeleton. These results demonstrate that the nanoscale organization of LAT-based signaling complexes is dynamic and indicates that different kinds of LAT-based complexes appear at different times during T cell activation. PMID:27875277

Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells

PubMed Central

Miyazaki, Taisuke; Yamasaki, Miwako; Hashimoto, Kouichi; Kohda, Kazuhisa; Yuzaki, Michisuke; Shimamoto, Keiko; Tanaka, Kohichi; Kano, Masanobu; Watanabe, Masahiko

2017-01-01

Astrocytes regulate synaptic transmission through controlling neurotransmitter concentrations around synapses. Little is known, however, about their roles in neural circuit development. Here we report that Bergmann glia (BG), specialized cerebellar astrocytes that thoroughly enwrap Purkinje cells (PCs), are essential for synaptic organization in PCs through the action of the l-glutamate/l-aspartate transporter (GLAST). In GLAST-knockout mice, dendritic innervation by the main ascending climbing fiber (CF) branch was significantly weakened, whereas the transverse branch, which is thin and nonsynaptogenic in control mice, was transformed into thick and synaptogenic branches. Both types of CF branches frequently produced aberrant wiring to proximal and distal dendrites, causing multiple CF–PC innervation. Our electrophysiological analysis revealed that slow and small CF-evoked excitatory postsynaptic currents (EPSCs) were recorded from almost all PCs in GLAST-knockout mice. These atypical CF-EPSCs were far more numerous and had significantly faster 10–90% rise time than those elicited by glutamate spillover under pharmacological blockade of glial glutamate transporters. Innervation by parallel fibers (PFs) was also affected. PF synapses were robustly increased in the entire dendritic trees, leading to impaired segregation of CF and PF territories. Furthermore, lamellate BG processes were retracted from PC dendrites and synapses, leading to the exposure of these neuronal elements to the extracellular milieus. These synaptic and glial phenotypes were reproduced in wild-type mice after functional blockade of glial glutamate transporters. These findings highlight that glutamate transporter function by GLAST on BG plays important roles in development and maintenance of proper synaptic wiring and wrapping in PCs. PMID:28655840

Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.

PubMed

Kühne, Annett; Kaiser, Rolf; Schirmer, Markus; Heider, Ulrike; Muhlke, Sabine; Niere, Wiebke; Overbeck, Tobias; Hohloch, Karin; Trümper, Lorenz; Sezer, Orhan; Brockmöller, Jürgen

2007-07-01

Melphalan is widely used in the treatment of multiple myeloma. Pharmacokinetics of this alkylating drug shows high inter-individual variability. As melphalan is a phenylalanine derivative, the pharmacokinetic variability may be determined by genetic polymorphisms in the L-type amino acid transporters LAT1 (SLC7A5) and LAT2 (SLC7A8). Pharmacokinetics were analysed in 64 patients after first administration of intravenous melphalan. Severity of side effects was documented according to WHO criteria. Genomic DNA was analysed for polymorphisms in LAT1 and LAT2 by sequencing of the entire coding region, intron-exon boundaries and 2 kb upstream promoter region. Selected polymorphisms in the common heavy chain of both transporters, the protein 4F2hc (SLC3A2), were analysed by single nucleotide primer extension. Melphalan pharmacokinetics was highly variable with up to 6.2-fold differences in total clearance. A total of 44 polymorphisms were identified in LAT1 and 21 polymorphisms in LAT2. From all variants, only five were in the coding region and only one heterozygous non-synonymous polymorphism (Ala94Thr) was found in LAT2. Numerous polymorphisms were found in the LAT1 and LAT2 5'-flanking regions but did not correlate with expression of the respective genes. No significant correlations could be observed between the polymorphisms in 4F2hc, LAT1, and LAT2 with melphalan pharmacokinetics or with melphalan side effects. The study confirmed that these transporter genes are highly conserved, particularly in the coding sequences. Genetic variation in 4F2hc, LAT1, and LAT2 does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.

Fermi Sees the Gamma Ray Sky

NASA Image and Video Library

2009-10-30

This view of the gamma-ray sky constructed from one year of Fermi LAT observations is the best view of the extreme universe to date. The map shows the rate at which the LAT detects gamma rays with energies above 300 million electron volts -- about 120 million times the energy of visible light -- from different sky directions. Brighter colors equal higher rates. Credit: NASA/DOE/Fermi LAT Collaboration Full story: www.nasa.gov/mission_pages/GLAST/news/first_year.html

Latency-associated transcript (LAT) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LAT.

PubMed

Bertke, Andrea S; Patel, Amita; Imai, Yumi; Apakupakul, Kathleen; Margolis, Todd P; Krause, Philip R

2009-10-01

Herpes simplex virus 1 (HSV-1) and HSV-2 cause similar acute infections but differ in their abilities to reactivate from trigeminal and lumbosacral dorsal root ganglia. During latency, HSV-1 and HSV-2 also preferentially express their latency-associated transcripts (LATs) in different sensory neuronal subtypes that are positive for A5 and KH10 markers, respectively. Chimeric virus studies showed that LAT region sequences influence both of these viral species-specific phenotypes. To further map the LAT region sequences responsible for these phenotypes, we constructed the chimeric virus HSV2-LAT-E1, in which exon 1 (from the LAT TATA to the intron splice site) was replaced by the corresponding sequence from HSV-1 LAT. In intravaginally infected guinea pigs, HSV2-LAT-E1 reactivated inefficiently relative to the efficiency of its rescuant and wild-type HSV-2, but it yielded similar levels of viral DNA, LAT, and ICP0 during acute and latent infection. HSV2-LAT-E1 preferentially expressed the LAT in A5+ neurons (as does HSV-1), while the chimeric viruses HSV2-LAT-P1 (LAT promoter swap) and HSV2-LAT-S1 (LAT sequence swap downstream of the promoter) exhibited neuron subtype-specific latent LAT expression phenotypes more similar to that of HSV-2 than that of HSV-1. Rescuant viruses displayed the wild-type HSV-2 phenotypes of efficient reactivation in the guinea pig genital model and a tendency to express LAT in KH10+ neurons. The region that is critical for HSV species-specific differences in latency and reactivation thus lies between the LAT TATA and the intron splice site, and minor differences in the 5' ends of chimeric sequences in HSV2-LAT-E1 and HSV2-LAT-S1 point to sequences immediately downstream of the LAT TATA.

Afterglow Population Studies from Swift Follow-Up Observations of Fermi LAT GRBs

NASA Technical Reports Server (NTRS)

Racusin, Judith L.; Oates, S. R.; McEnery, J.; Vasileiou, V.; Troja, E.; Gehrels, N.

2010-01-01

The small population of Fermi LAT detected GRBs discovered over the last year has been providing interesting and unexpected clues into GRB prompt and afterglow emission mechanisms. Over the last 5 years, it has been Swift that has provided the robust data set of UV/optical and X-ray afterglow observations that opened many windows into other components of GRB emission structure. We explore the new ability to utilize both of these observatories to study the same GRBs over 10 orders of magnitude in energy, although not always concurrently. Almost all LAT GRBs that have been followed-up by Swift within 1-day have been clearly detected and carefully observed. We will present the context of the lower-energy afterglows of this special subset of GRBs that has > 100 MeV emission compared to the hundreds in the Swift database that may or may not have been observed by LAT, and theorize upon the relationship between these properties and the origin of the high energy gamma-ray emission.

Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency associated transcript (LAT) negative mutant dLAT2903 with a disrupted LAT miR-H2

PubMed Central

Jiang, Xianzhi; Brown, Don; Osorio, Nelson; Hsiang, Chinhui; BenMohamed, Lbachir; Wechsler, Steven L.

2015-01-01

At least six microRNAs (miRNAs) appear to be encoded by the latency associated transcript (LAT) of herpes simplex virus type 1 (HSV-1). The gene for ICP0, an important immediate early (IE) viral protein, is antisense to, and overlaps with, the region of LAT from which miRNA H2 (miR-H2) is derived. We recently reported that a mutant (McK-ΔH2) disrupted for miR-H2 on the wild type HSV-1 strain McKrae genomic background has increased ICP0 expression, increased neurovirulence, and slightly more rapid reactivation. We report here that HSV-1 mutants deleted for the LAT promoter nonetheless make significant amounts of miR-H2 during lytic tissue culture infection, presumably via readthrough transcription from an upstream promoter. To determine if miR-H2 might also play a role in the HSV-1 latency-reactivation cycle of a LAT negative mutant, we constructed dLAT-ΔH2, in which miR-H2 is disrupted in dLAT2903 without altering the predicted amino acid sequence of the overlapping ICP0 open reading frame. Similar to McK-ΔH2, dLAT-ΔH2 expressed more ICP0, was more neurovirulent, and had increased reactivation in the mouse TG explant induced reactivation model of HSV-1 compared to its parental virus. Interestingly, although the increased reactivation of McK-ΔH2 compared to its parental wt virus was subtle and only detected at very early times after explant TG induced reactivation, the increased reactivation of dLAT-ΔH2 compared to its dLAT2903 parental virus appeared more robust and was significantly increased even at late times after induction. These results confirm that miR-H2 plays a role in modulating the HSV-1 reactivation phenotype. PMID:26069184

In vivo contribution of nestin- and GLAST-lineage cells to adult hippocampal neurogenesis

PubMed Central

DeCarolis, Nathan A.; Mechanic, Maxwell; Petrik, David; Carlton, Adam; Ables, Jessica L.; Malhotra, Shveta; Bachoo, Robert; Götz, Magdalena; Lagace, Diane C.; Eisch, Amelia J.

2013-01-01

Radial glia-like cells (RGCs) are the hypothesized source of adult hippocampal neurogenesis. However, the current model of hippocampal neurogenesis does not fully incorporate the in vivo heterogeneity of RGCs. In order to better understand the contribution of different RGC subtypes to adult hippocampal neurogenesis, we employed widely-used transgenic lines (Nestin-CreERT2 and GLAST∷CreERT2 mice) to explore how RGCs contribute to neurogenesis under basal conditions and after stimulation and depletion of neural progenitor cells. We first used these inducible fate-tracking transgenic lines to define the similarities and differences in the contribution of nestin- and GLAST-lineage cells to basal long-term hippocampal neurogenesis. We then explored the ability of nestin- and GLAST-lineage RGCs to contribute to neurogenesis, after experimental manipulations that either ablate neurogenesis (i.c.v. application of the anti-mitotic AraC, cytosine-β-D-arabinofuranoside) or stimulate neurogenesis (wheel running). Interestingly, in both ablation and stimulation experiments, labeled RGCs in GLAST∷CreERT2 mice appear to contribute to neurogenesis, whereas RGCs in Nestin-CreERT2 mice do not. Finally, using NestinGFP reporter mice, we expanded on previous research by showing that not all RGCs in the adult dentate gyrus subgranular zone express nestin, and therefore RGCs are antigenically heterogeneous. These findings are important for the field, as they allow appropriately conservative interpretation of existing and future data that emerge from these inducible transgenic lines. These findings also raise important questions about the differences between transgenic driver lines, the heterogeneity of RGCs, and the potential differences in progenitor cell behavior between transgenic lines. As these findings highlight the possible differences in the contribution of nestin and GLAST lineage cells to long-term neurogenesis in vivo, they indicate that the current models of hippocampal

Fermi-LAT Observations of the LIGO Event GW150914

DOE PAGES

Ackermann, M.; Ajello, M.; Albert, A.; ...

2016-05-12

The Fermi Large Area Telescope (LAT) has an instantaneous field of view (FoV) covering ~1/5 of the sky and it completes a survey of the entire sky in high-energy gamma-rays every 3 hr. It enables searches for transient phenomena over timescales from milliseconds to years. Among these phenomena could be electromagnetic counterparts to gravitational wave (GW) sources. In this study, we present a detailed study of the LAT observations relevant to Laser Interferometer Gravitational-wave Observatory (LIGO) event GW150914, which is the first direct detection of gravitational waves and has been interpreted as being due to the coalescence of two stellar-massmore » black holes. The localization region for GW150914 was outside the LAT FoV at the time of the GW signal. However, as part of routine survey observations, the LAT observed the entire LIGO localization region within ~70 minutes of the trigger and thus enabled a comprehensive search for a γ-ray counterpart to GW150914. Finally, the study of the LAT data presented here did not find any potential counterparts to GW150914, but it did provide limits on the presence of a transient counterpart above 100 MeV on timescales of hours to days over the entire GW150914 localization region.« less

Fermi (Formerly GLAST) at Six Months

NASA Technical Reports Server (NTRS)

Ritz, Steven M.

2009-01-01

The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to more than 300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.

Fermi (nee GLAST) at Six Months

NASA Technical Reports Server (NTRS)

Ritz, Steve

2009-01-01

The Fermi Gamma-ray Space Telescope, formerly called GLAST, is a mission to measure the cosmic gamma-ray flux in the energy range 20 MeV to >300 GeV, with supporting measurements for gamma-ray bursts from 8 keV to 30 MeV. In addition to breakthrough capabilities in energy coverage and localization, the very large field of view enables observations of 20% of the sky at any instant, and the entire sky on a timescale of a few hours. With its recent launch on 11 June 2008, Fermi now opens a new and important window on a wide variety of phenomena, including pulsars, black holes and active galactic nuclei, gamma-ray bursts, the origin of cosmic rays and supernova remnants, and searches for hypothetical new phenomena such as supersymmetric dark matter annihilations. In addition to early results and the science opportunities, this talk includes a description of the instruments and the mission status and plans.

A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): A pilot study in a canine model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fukumoto, Shinya; Hanazono, Kiwamu; Fu, Dah-Renn

2013-09-13

Highlights: •LAT1 is highly expressed in tumors but at low levels in normal tissues. •We examine LAT1 expression and function in malignant melanoma (MM). •LAT1 expression in MM tissues and cell lines is higher than those in normal tissues. •LAT1 selective inhibitors inhibit amino acid uptake and cell growth in MM cells. •New chemotherapeutic protocols including LAT1 inhibitors are effective for treatment. -- Abstract: L-type amino acid transporter 1 (LAT1), an isoform of amino acid transport system L, transports branched or aromatic amino acids essential for fundamental cellular activities such as cellular growth, proliferation and maintenance. This amino acid transportermore » recently has received attention because of its preferential and up-regulated expression in a variety of human tumors in contrast to its limited distribution and low-level expression in normal tissues. In this study, we explored the feasibility of using LAT1 inhibitor as a new therapeutic agent for human malignant melanomas (MM) using canine spontaneous MM as a model for human MM. A comparative study of LAT expression was performed in 48 normal tissues, 25 MM tissues and five cell lines established from MM. The study observed LAT1 mRNA levels from MM tissues and cell lines that were significantly (P < 0.01) higher than in normal tissues. Additionally, MM with distant metastasis showed a higher expression than those without distant metastasis. Functional analysis of LAT1 was performed on one of the five cell lines, CMeC-1. [{sup 3}H]L-Leucine uptake and cellular growth activities in CMeC-1 were inhibited in a dose-dependent manner by selective LAT1 inhibitors (2-amino-2-norbornane-carboxylic acid, BCH and melphalan, LPM). Inhibitory growth activities of various conventional anti-cancer drugs, including carboplatin, cyclophosphamide, dacarbazine, doxorubicin, mitoxantrone, nimustine, vinblastine and vincristine, were significantly (P < 0.05) enhanced by combination use with BCH or

Involvement of LAT1 and LAT2 in the high- and low-affinity transport of L-leucine in human retinal pigment epithelial cells (ARPE-19 cells).

PubMed

Yamamoto, Atsushi; Akanuma, Shin-Ichi; Tachikawa, Masanori; Hosoya, Ken-Ichi

2010-05-01

System L, which is encoded by LAT1 and LAT2, is an amino acid transport system that transports neutral amino acids, including several essential amino acids in an Na+-independent manner. Due to its broad substrate selectivity, system L has been proposed to mediate the transport of amino-acid-related drugs across the blood-tissue barriers. We characterized L-leucine transport and its corresponding transporter in a human retinal pigment epithelial cell line (ARPE-19 cells) as an in vitro model of the outer blood-retinal barrier. [3H]L-leucine uptake by ARPE-19 cells took place in an Na+-, Cl(-)-independent and saturable manner with K(m) values of 8.71 and 220 microM. This process was more potently cis-inhibited by substrates of LAT1 than those of LAT2. [3H]L-leucine efflux from ARPE-19 cells was trans-stimulated by substrates of LAT1 and LAT2 through the obligatory exchange mechanism of system L. Although RT-PCR analysis demonstrated that LAT1 and LAT2 mRNA are expressed in ARPE-19 cells, the LAT1 mRNA concentration is 42-fold higher than that of LAT2. Moreover, immunoblot analysis demonstrated that LAT1 is expressed in ARPE-19 cells. In conclusion, although the transport function of LAT1 is greater than that of LAT2, LAT1 and LAT2 are involved in L-leucine transport in ARPE-19 cells.

Fermi-LAT Observations of the LIGO Event GW150914

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Albert, A.; Anderson, B.; Arimoto, M.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.;

The First FERMI-LAT Gamma-Ray Burst Catalog

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Asano, K.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.;

The first Fermi-LAT Gamma-Ray burst catalog

DOE PAGES

Ackermann, M.; Ajello, M.; Asano, K.; ...

2013-10-23

In three years of observations since the beginning of nominal science operations in 2008 August, the Large Area Telescope (LAT) on board the Fermi Gamma-Ray Space Telescope has observed high-energy (gsim 20 MeV) γ-ray emission from 35 gamma-ray bursts (GRBs). Among these, 28 GRBs have been detected above 100 MeV and 7 GRBs above ~20 MeV. The first Fermi-LAT catalog of GRBs is a compilation of these detections and provides a systematic study of high-energy emission from GRBs for the first time. To generate the catalog, we examined 733 GRBs detected by the Gamma-Ray Burst Monitor (GBM) on Fermi andmore » processed each of them using the same analysis sequence. Details of the methodology followed by the LAT collaboration for the GRB analysis are provided. Here, we summarize the temporal and spectral properties of the LAT-detected GRBs. We also discuss characteristics of LAT-detected emission such as its delayed onset and longer duration compared with emission detected by the GBM, its power-law temporal decay at late times, and the fact that it is dominated by a power-law spectral component that appears in addition to the usual Band model.« less

Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation.

PubMed

Vidal, Rebeca; Garro-Martínez, Emilio; Díaz, Álvaro; Castro, Elena; Florensa-Zanuy, Eva; Taketo, Makoto M; Pazos, Ángel; Pilar-Cuéllar, Fuencisla

2018-05-08

β-catenin (key mediator in the Wnt signaling pathway) contributes to the pathophysiology of mood disorders, associated to neurogenesis and neuroplasticity. Decreased β-catenin protein levels have been observed in the hippocampus and prefrontal cortex of depressed subjects. Additionally, the antidepressants exert, at least in part, their neurogenic effects by increasing β-catenin levels in the subgranular zone of the hippocampus. To further understand the role of β-catenin in depression and anxiety, we generated two conditional transgenic mice in which β-catenin was either inactivated or stabilized in cells expressing CreERT under the control of the astrocyte-specific glutamate transporter (GLAST) promoter inducible by tamoxifen, which presents high expression levels on the subgranular zone of the hippocampus. Here, we show that β-catenin inactivation in GLAST-expressing cells enhanced anxious/depressive-like responses. These behavioral changes were associated with impaired hippocampal proliferation and markers of immature neurons as doublecortin. On the other hand, β-catenin stabilization induced an anxiolytic-like effect in the novelty suppressed feeding test and tended to ameliorate depressive-related behaviors. In these mice, the control over the Wnt/β-catenin pathway seems to be tighter as evidenced by the lack of changes in some proliferation markers. Moreover, animals with stabilized β-catenin showed resilience to some anxious/depressive manifestations when subjected to the corticosterone model of depression. Our findings demonstrate that β-catenin present in GLAST-expressing cells plays a critical role in the development of anxious/depressive-like behaviors and resilience, which parallels its regulatory function on hippocampal proliferation. Further studies need to be done to clarify the importance of these changes in other brain areas also implicated in the neurobiology of anxiety and depressive disorders.

New genetic variants of LATS1 detected in urinary bladder and colon cancer.

PubMed

Saadeldin, Mona K; Shawer, Heba; Mostafa, Ahmed; Kassem, Neemat M; Amleh, Asma; Siam, Rania

2014-01-01

LATS1, the large tumor suppressor 1 gene, encodes for a serine/threonine kinase protein and is implicated in cell cycle progression. LATS1 is down-regulated in various human cancers, such as breast cancer, and astrocytoma. Point mutations in LATS1 were reported in human sarcomas. Additionally, loss of heterozygosity of LATS1 chromosomal region predisposes to breast, ovarian, and cervical tumors. In the current study, we investigated LATS1 genetic variations including single nucleotide polymorphisms (SNPs), in 28 Egyptian patients with either urinary bladder or colon cancers. The LATS1 gene was amplified and sequenced and the expression of LATS1 at the RNA level was assessed in 12 urinary bladder cancer samples. We report, the identification of a total of 29 variants including previously identified SNPs within LATS1 coding and non-coding sequences. A total of 18 variants were novel. Majority of the novel variants, 13, were mapped to intronic sequences and un-translated regions of the gene. Four of the five novel variants located in the coding region of the gene, represented missense mutations within the serine/threonine kinase catalytic domain. Interestingly, LATS1 RNA steady state levels was lost in urinary bladder cancerous tissue harboring four specific SNPs (16045 + 41736 + 34614 + 56177) positioned in the 5'UTR, intron 6, and two silent mutations within exon 4 and exon 8, respectively. This study identifies novel single-base-sequence alterations in the LATS1 gene. These newly identified variants could potentially be used as novel diagnostic or prognostic tools in cancer.

Gamma-ray Albedo of the Moon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, Igor V.; Porter, Troy A.

2007-06-14

We use the GEANT4 Monte Carlo framework to calculate the gamma-ray albedo of the Moon due to interactions of cosmic ray (CR) nuclei with moon rock. Our calculation of the albedo spectrum agrees with the EGRET data. We show that the spectrum of gamma-rays from the Moon is very steep with an effective cutoff around 3 GeV (600 MeV for the inner part of the Moon disc). Since it is the only (almost) black spot in the gamma-ray sky, it provides a unique opportunity for calibration of gamma-ray telescopes, such as the forthcoming Gamma Ray Large Area Space Telescope (GLAST).more » The albedo flux depends on the incident CR spectrum which changes over the solar cycle. Therefore, it is possible to monitor the CR spectrum using the albedo gamma-ray flux. Simultaneous measurements of CR proton and helium spectra by the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA), and observations of the albedo -rays by the GLAST Large Area Telescope (LAT), can be used to test the model predictions and will enable the GLAST LAT to monitor the CR spectrum near the Earth beyond the lifetime of PAMELA.« less

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction.

PubMed

Verma, Apoorva; Jing-Song, Fan; Finch-Edmondson, Megan L; Velazquez-Campoy, Adrian; Balasegaran, Shanker; Sudol, Marius; Sivaraman, Jayaraman

2018-01-30

YES-associated protein (YAP) is a major effector protein of the Hippo tumor suppressor pathway, and is phosphorylated by the serine/threonine kinase LATS. Their binding is mediated by the interaction between WW domains of YAP and PPxY motifs of LATS. Their isoforms, YAP2 and LATS1 contain two WW domains and two PPxY motifs respectively. Here, we report the study of the interaction of these domains both in vitro and in human cell lines, to better understand the mechanism of their binding. We show that there is a reciprocal binding preference of YAP2-WW1 with LATS1-PPxY2, and YAP2-WW2 with LATS1-PPxY1. We solved the NMR structures of these complexes and identified several conserved residues that play a critical role in binding. We further created a YAP2 mutant by swapping the WW domains, and found that YAP2 phosphorylation at S127 by LATS1 is not affected by the spatial configuration of its WW domains. This is likely because the region between the PPxY motifs of LATS1 is unstructured, even upon binding with its partner. Based on our observations, we propose possible models for the interaction between YAP2 and LATS1.

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction

PubMed Central

Verma, Apoorva; Jing-Song, Fan; Finch-Edmondson, Megan L.; Velazquez-Campoy, Adrian; Balasegaran, Shanker; Sudol, Marius; Sivaraman, Jayaraman

2018-01-01

YES-associated protein (YAP) is a major effector protein of the Hippo tumor suppressor pathway, and is phosphorylated by the serine/threonine kinase LATS. Their binding is mediated by the interaction between WW domains of YAP and PPxY motifs of LATS. Their isoforms, YAP2 and LATS1 contain two WW domains and two PPxY motifs respectively. Here, we report the study of the interaction of these domains both in vitro and in human cell lines, to better understand the mechanism of their binding. We show that there is a reciprocal binding preference of YAP2-WW1 with LATS1-PPxY2, and YAP2-WW2 with LATS1-PPxY1. We solved the NMR structures of these complexes and identified several conserved residues that play a critical role in binding. We further created a YAP2 mutant by swapping the WW domains, and found that YAP2 phosphorylation at S127 by LATS1 is not affected by the spatial configuration of its WW domains. This is likely because the region between the PPxY motifs of LATS1 is unstructured, even upon binding with its partner. Based on our observations, we propose possible models for the interaction between YAP2 and LATS1. PMID:29487715

Herpes Simplex Virus 2 Latency-Associated Transcript (LAT) region mutations do not identify a role for LAT-Associated Micro RNAs in viral reactivation in the Guinea Pig Genital Model.

PubMed

Kawamura, Yoshiki; Bosch-Marce, Marta; Tang, Shuang; Patel, Amita; Krause, Philip R

2018-05-02

Despite the long-standing observation that herpes simplex virus (HSV) Latency-Associated Transcript (LAT) promoter-deletion viruses show impaired recurrence phenotypes in relevant animal models, the mechanism by which these sequences exert this phenotypic effect is unknown. We constructed and evaluated four mutant HSV-2 viruses with targeted mutations in the LAT promoter and LAT-associated miRNAs affecting (1) the LAT TATA box, (2) the LAT ICP4-binding site, (3) miR-I and miR-II (miR-I/II), which both target ICP34.5, and (4) miR-III, which targets ICP0. While the LAT-TATA box mutant caused milder acute infections than wild-type (WT), there was no difference in recurrence phenotype between these viruses. LAT and miRNA expression during latency were not impaired by this mutation, suggesting that other promoter elements may be more important for latent HSV-2 LAT expression. Mutation of the LAT ICP4-binding site also did not cause an in vivo phenotypic difference between mutant and WT viruses. Acute infection and reactivation from latency of the miR-I/II mutant was similar to that of its rescuant, although slightly reduced in severity relative to the wild-type virus. The miR-III mutant also exhibited WT phenotypes in acute and recurrent phases of infection. While not ruling out an effect of these elements in human latency or reactivation, these findings do not identify a specific role for LAT or LAT-associated miRNAs in the HSV-2 LAT promoter deletion phenotype in guinea pigs. Thus, other sequences in this region may play a more important role in the long-studied LAT-associated phenotype in animals. IMPORTANCE While it has been known for several decades that specific HSV-1 and HSV-2 sequences near the LAT promoter are required for efficient viral reactivation in animal models, the mechanism is still not known. We constructed four mutant viruses with the goal of identifying critical sequence elements and of specifically testing the hypothesis that microRNAs that are

Fermi LAT Observations of Cosmic-Ray Electrons

NASA Technical Reports Server (NTRS)

Moiseev, Alexander

2011-01-01

Designed as a gamma-ray instrument, the LAT is a capable detector of high energy cosmic ray electrons. The LAT is composed of a 4x4 array of identical towers. Each tower has a Tracker and a Calorimeter module. Entire LAT is covered by segmented Anti-Coincidence Detector (ACD). The electron data analysis is based on that developed for photons. The main challenge is to identify and separate electrons from all other charged species, mainly CR protons (for gamma-ray analysis this is provided by the Anti-Coincidence Detector)

Why do intimate partners live apart? Evidence on LAT relationships across Europe

PubMed Central

Liefbroer, Aart C.; Poortman, Anne-Rigt; Seltzer, Judith A.

2015-01-01

BACKGROUND Most research asks whether or not cohabitation has come to rival marriage. Little is known about the meaning of living apart together (LAT) relationships, and whether LAT is an alternative to marriage and cohabitation or a dating relationship. OBJECTIVE We examine across Europe: (1) the prevalence of LAT, (2) the reasons for LAT, and (3) the correlates of (a) LAT relationships vis-à-vis being single, married, or cohabiting, and (b) different types of LAT union. METHODS Using Generations and Gender Survey data from ten Western and Eastern European countries, we present descriptive statistics about LATs and estimate multinominal logistic regression models to assess the correlates of being in different types of LAT unions. RESULTS LAT relationships are uncommon, but they are more common in Western than Eastern Europe. Most people in LAT unions intend to live together but are apart for practical reasons. LAT is more common among young people, those enrolled in higher education, people with liberal attitudes, highly educated people, and those who have previously cohabited or been married. Older people and divorced or widowed persons are more likely to choose LAT to maintain independence. Surprisingly, attitudinal and educational differences are more pronounced in Eastern Europe than in Western Europe. CONCLUSIONS A tentative conclusion is that LAT is more often a stage in the union formation process than an alternative to marriage and cohabitation. Yet some groups do view LAT as substituting for marriage and cohabitation, and these groups differ between East and West. In Eastern Europe a cultural, highly educated elite seems to be the first to resist traditional marriage norms and embrace LAT (and cohabitation) as alternative living arrangements, whereas this is less the case in Western Europe. In Western Europe, LAT unions are mainly an alternative for persons who have been married before or had children in a prior relationship. PMID:26085812

Laser-assisted tympanostomy (LAT) in adult individuals

NASA Astrophysics Data System (ADS)

Prokopakis, E. P.; Lachanas, V. A.; Helidonis, Emmanuel S.; Velegrakis, G.

2004-06-01

Objectives: To assess outcome, in adult individuals undergone Laser Assisted Tympanostomy (LAT) without ventilation tube placement. Method: LAT was performed on a total of 95 ears (72 individuals). Indications included serous otitis media with effusion (44 ears/31 patients), eustachian tube dysfunction (32 ears/24 patients), acute otitis media (13 ears/11 patients), and endoscopic visualization of the middle ear (6 ears/6 patients). Results: Middle ear disease was resolved after the closure of tympanostomy in 48% of patients with serous otitis media with effusion. In 78% of patients with Eustachian tube dysfunction symptoms were diminished. All patients with acute otitis media had a satisfactory outcome. LAT was found quite effective in patients undergoing middle ear endoscopy. Conclusion: LAT without ventilation tubes provides a safe alternative surgical option in adult patients in certain cases. The selection criteria for this procedure are addressed in detail.

In vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells is inhibited by the ethylmercury-containing preservative thimerosal.

PubMed

Mutkus, Lysette; Aschner, Judy L; Syversen, Tore; Shanker, Gouri; Sonnewald, Ursula; Aschner, Michael

2005-01-01

Thimerosal, also known as thimersal, Merthrolate, or sodiumethyl-mercurithiosalicylate, is an organic mercurial compound that is used in a variety of commercial as well as biomedical applications. As a preservative, it is used in a number of vaccines and pharmaceutical products. Its active ingredient is ethylmercury. Both inorganic and organic mercurials are known to interfere with glutamate homeostasis. Brain glutamate is removed mainly by astrocytes from the extracellular fluid via high-affinity astroglial Na+-dependent excitatory amino acid transporters, glutamate/ aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1). The effects of thimerosal on glutamate homeostasis have yet to be determined. As a first step in this process, we examined the effects of thimerosal on the transport of [3H]-d-aspartate, a nonmetabolizable glutamate analog, in Chinese hamster ovary (CHO) cells transfected with two glutamate transporter subtypes, GLAST (EAAT1) and GLT-1 (EAAT2). Additionally, studies were undertaken to determine the effects of thimerosal on mRNA and protein levels of these transporters. The results indicate that thimerosal treatment caused significant but selective changes in both glutamate transporter mRNA and protein expression in CHO cells. Thimerosal-mediated inhibition of glutamate transport in the CHO-K1 cell line DdB7 was more pronounced in the GLT-1-transfected cells compared with the GLAST- transfected cells. These studies suggest that thimerosal accumulation in the central nervous system might contribute to dysregulation of glutamate homeostasis.

Oncogenicity of L-type amino-acid transporter 1 (LAT1) revealed by targeted gene disruption in chicken DT40 cells: LAT1 is a promising molecular target for human cancer therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ohkawa, Mayumi; Ohno, Yoshiya; Masuko, Kazue

Highlights: {yields} We established LAT1 amino-acid transporter-disrupted DT40 cells. {yields} LAT1-disrupted cells showed slow growth and lost the oncogenicity. {yields} siRNA and mAb inhibited human tumor growth in vitro and in vivo. {yields} LAT1 is a promising target molecule for cancer therapy. -- Abstract: L-type amino-acid transporter 1 (LAT1) is the first identified light chain of CD98 molecule, disulfide-linked to a heavy chain of CD98. Following cDNA cloning of chicken full-length LAT1, we have constructed targeting vectors for the disruption of chicken LAT1 gene from genomic DNA of chicken LAT1 consisting of 5.4 kb. We established five homozygous LAT1-disrupted (LAT1{supmore » -/-}) cell clones, derived from a heterozygous LAT1{sup +/-} clone of DT40 chicken B cell line. Reactivity of anti-chicken CD98hc monoclonal antibody (mAb) with LAT1{sup -/-} DT40 cells was markedly decreased compared with that of wild-type DT40 cells. All LAT1{sup -/-} cells were deficient in L-type amino-acid transporting activity, although alternative-splice variant but not full-length mRNA of LAT1 was detected in these cells. LAT1{sup -/-} DT40 clones showed outstandingly slow growth in liquid culture and decreased colony-formation capacity in soft agar compared with wild-type DT40 cells. Cell-cycle analyses indicated that LAT1{sup -/-} DT40 clones have prolonged cell-cycle phases compared with wild-type or LAT1{sup +/-} DT40 cells. Knockdown of human LAT1 by small interfering RNAs resulted in marked in vitro cell-growth inhibition of human cancer cells, and in vivo tumor growth of HeLa cells in athymic mice was significantly inhibited by anti-human LAT1 mAb. All these results indicate essential roles of LAT1 in the cell proliferation and occurrence of malignant phenotypes and that LAT1 is a promising candidate as a molecular target of human cancer therapy.« less

Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth.

PubMed

Wang, Qian; Grkovic, Tanja; Font, Josep; Bonham, Sarah; Pouwer, Rebecca H; Bailey, Charles G; Moran, Anne M; Ryan, Renae M; Rasko, John E J; Jormakka, Mika; Quinn, Ronald J; Holst, Jeff

2014-06-20

The L-type amino acid transporter (LAT) family consists of four members (LAT1-4) that mediate uptake of neutral amino acids including leucine. Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signaling leading to protein translation. As such, LAT family members are commonly upregulated in cancer in order to fuel increased protein translation and cell growth. To identify potential LAT-specific inhibitors, we established a function-based high-throughput screen using a prefractionated natural product library. We identified and purified two novel monoterpene glycosides, ESK242 and ESK246, sourced from a Queensland collection of the plant Pittosporum venulosum. Using Xenopus laevis oocytes expressing individual LAT family members, we demonstrated that ESK246 preferentially inhibits leucine transport via LAT3, while ESK242 inhibits both LAT1 and LAT3. We further show in LNCaP prostate cancer cells that ESK246 is a potent (IC50 = 8.12 μM) inhibitor of leucine uptake, leading to reduced mTORC1 signaling, cell cycle protein expression and cell proliferation. Our study suggests that ESK246 is a LAT3 inhibitor that can be used to study LAT3 function and upon which new antiprostate cancer therapies may be based.

Monoterpene Glycoside ESK246 from Pittosporum Targets LAT3 Amino Acid Transport and Prostate Cancer Cell Growth

PubMed Central

2014-01-01

The l-type amino acid transporter (LAT) family consists of four members (LAT1–4) that mediate uptake of neutral amino acids including leucine. Leucine is not only important as a building block for proteins, but plays a critical role in mTORC1 signaling leading to protein translation. As such, LAT family members are commonly upregulated in cancer in order to fuel increased protein translation and cell growth. To identify potential LAT-specific inhibitors, we established a function-based high-throughput screen using a prefractionated natural product library. We identified and purified two novel monoterpene glycosides, ESK242 and ESK246, sourced from a Queensland collection of the plant Pittosporum venulosum. Using Xenopus laevis oocytes expressing individual LAT family members, we demonstrated that ESK246 preferentially inhibits leucine transport via LAT3, while ESK242 inhibits both LAT1 and LAT3. We further show in LNCaP prostate cancer cells that ESK246 is a potent (IC50 = 8.12 μM) inhibitor of leucine uptake, leading to reduced mTORC1 signaling, cell cycle protein expression and cell proliferation. Our study suggests that ESK246 is a LAT3 inhibitor that can be used to study LAT3 function and upon which new antiprostate cancer therapies may be based. PMID:24762008

The Fermi LAT Very Important Project (VIP) List of Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Thompson, David J.; Fermi Large Area Telescope Collaboration

2018-01-01

Using nine years of Fermi Gamma-ray Space Telescope Large Area Telescope (LAT) observations, we have identified 30 projects for Active Galactic Nuclei (AGN) that appear to provide strong prospects for significant scientific advances. This Very Important Project (VIP) AGN list includes AGNs that have good multiwavelength coverage, are regularly detected by the Fermi LAT, and offer scientifically interesting timing or spectral properties. Each project has one or more LAT scientists identified who are actively monitoring the source. They will be regularly updating the LAT results for these VIP AGNs, working together with multiwavelength observers and theorists to maximize the scientific return during the coming years of the Fermi mission. See https://confluence.slac.stanford.edu/display/GLAMCOG/VIP+List+of+AGNs+for+Continued+Study

Fermi-LAT Gamma-ray Bursts and Insight from Swift

NASA Technical Reports Server (NTRS)

Racusin, Judith L.

2011-01-01

A new revolution in GRB observation and theory has begun over the last 3 years since the launch of the Fermi gamma-ray space telescope. The new window into high energy gamma-rays opened by the Fermi-LAT is providing insight into prompt emission mechanisms and possibly also afterglow physics. The LAT detected GRBs appear to be a new unique subset of extremely energetic and bright bursts. In this talk I will discuss the context and recent discoveries from these LAT GRBs and the large database of broadband observations collected by Swift over the last 7 years and how through comparisons between the Swift, GBM, and LAT GRB samples, we can learn about the unique characteristics and relationships between each population.

Cap and trade schemes on waste management: A case study of the Landfill Allowance Trading Scheme (LATS) in England

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calaf-Forn, Maria, E-mail: mcalaf@ent.cat; ENT Environment and Management, Carrer Sant Joan 39, First Floor, E-08800 Vilanova i la Geltrú, Barcelona; Roca, Jordi

Highlights: • LATS has been effective to achieve a reduction of the amount of landfilled waste. • LATS has been one of the few environmental instruments for waste management with a cap and trade methodology. • LATS has achieved to increase recycling of the biodegradable and other waste fractions. - Abstract: The Landfill Allowance Trading Scheme (LATS) is one of the main instruments used in England to enforce the landfill diversion targets established in the Directive 1999/31/EC of the European Parliament and of the Council of 26 April 1999 on the landfill of waste (Landfill Directive). Through the LATS, biodegradablemore » municipal waste (BMW) allowances for landfilling are allocated to each local authority, otherwise known as waste disposal authorities (WDAs). The quantity of landfill allowances received is expected to decrease continuously from 2005/06 to 2019/20 so as to meet the objectives of the Landfill Directive. To achieve their commitments, WDAs can exchange, buy, sell or transfer allowances among each other, or may re-profile their own allocation through banking and/or borrowing. Despite the goals for the first seven years – which included two target years (2005/06 and 2009/10) – being widely achieved (the average allocation of allowances per WDA was 22.9% higher than those finally used), market activity among WDAs was high and prices were not very stable. Results in terms of waste reduction and recycling levels have been satisfactory. The reduction of BMW landfilled (in percentage) was higher during the first seven years of the LATS period (2005/06–2011/12) (around 7% annually) than during the previous period (2001/02–2004/05) (4.2% annually). Since 2008, the significance of the LATS diminished because of an increase in the rate of the UK Landfill Tax. The LATS was suppressed after the 2012/13 target year, before what it was initially scheduled. The purpose of this paper is to describe the particularities of the LATS, analyse its

Chandra and Swift Observations of Unidentified Fermi-LAT Objects

NASA Astrophysics Data System (ADS)

Donato, Davide; Cheung, T.; Gehrels, N.

2010-03-01

In the last year we targeted some of the unidentified Fermi-LAT objects (UFOs) at high Galactic latitude with Chandra and Swift in order to determine the basic properties (positions, fluxes, hardness ratios) of all X-ray sources within the Fermi-LAT localization circles. These satellites enable us to detect the X-ray conterparts with a flux limit that is at least an order of magnitude lower than achieved in extant RASS data and to further follow-up at other wavelengths, with the ultimate goal to reveal the nature of these enigmatic gamma-ray sources. Here we present the results obtained with 5 Chandra pointings of high Galactic latitude UFOs in the Fermi-LAT 3-months bright source list. The association of detected X-ray sources within the improved 11-months Fermi-LAT localization circles with available optical and radio observations is discussed.

A cross-correlation study of the Fermi-LAT γ-ray diffuse extragalactic signal

DOE PAGES

Xia, Jun -Qing; Cuoco, Alessandro; Branchini, Enzo; ...

2011-09-12

In this work, starting from 21 months of data from the Fermi Large Area Telescope (LAT), we derive maps of the residual isotropic γ-ray emission, a relevant fraction of which is expected to be contributed by the extragalactic diffuse γ-ray background (EGB). We search for the auto-correlation signals in the above γ-ray maps and for the cross-correlation signal with the angular distribution of different classes of objects that trace the large-scale structure of the Universe. We compute the angular two-point auto-correlation function of the residual Fermi-LAT maps at energies E > 1 GeV, E > 3 GeV and E >more » 30 GeV well above the Galactic plane and find no significant correlation signal. This is, indeed, what is expected if the EGB were contributed by BL Lacertae (BLLacs), Flat Spectrum Radio Quasars (FSRQs) or star-forming galaxies, since, in this case, the predicted signal is very weak. Then, we search for the Integrated Sachs–Wolfe (ISW) signature by cross-correlating the Fermi-LAT maps with the 7-year Wilkinson Microwave Anisotropy Probe ( WMAP7) cosmic microwave background map. We find a cross-correlation consistent with zero, even though the expected signal is larger than that of the EGB auto-correlation. Lastly, in an attempt to constrain the nature of the γ-ray background, we cross-correlate the Fermi-LAT maps with the angular distributions of objects that may contribute to the EGB: quasi-stellar objects (QSOs) in the Sloan Digital Sky Survey Data Release 6 (SDSS-DR6) catalogue, NRAO VLA Sky Survey (NVSS) galaxies, Two Micron All Sky Survey (2MASS) galaxies and Luminous Red Galaxies (LRGs) in the SDSS catalogue. The cross-correlation is always consistent with zero, in agreement with theoretical expectations, but we find (with low statistical significance) some interesting features that may indicate that some specific classes of objects contribute to the EGB. A χ 2 analysis confirms that the correlation properties of the 21-month data do not provide

Canine Lat1: molecular structure, distribution and its expression in cancer samples.

PubMed

Ochiai, Hideharu; Morishita, Taiki; Onda, Ken; Sugiyama, Hiroki; Maruo, Takuya

2012-07-01

A full-length cDNA sequence of canine L-type amino acid transporter 1 (Lat1) was determined from a canine brain. The sequence was 1828 bp long and was predicted to encode 485 amino acid polypeptides. The deduced amino acid sequence of canine Lat1 showed 93.2% and 91.1% similarities to those of humans and rats, respectively. Northern blot analysis detected Lat1 expression in the cerebellum at 4 kb, and Western blot analysis showed a single band at 40 kDa. RT-PCR analysis revealed a distinct expression of Lat1 in the pancreas and testis in addition to the cerebrum and cerebellum. Notably, Lat1 expression was observed in the tissues of thyroid cancer, melanoma and hemangiopericytoma. Although the cancer samples examined were not enough, Lat1 may serve as a useful biomarker of cancer cells in veterinary clinic.

LatMix 2011 and 2012 Dispersion Analysis

DTIC Science & Technology

2017-05-15

was to complete the analysis and write -up of additional manuscripts relating to LatMix, and to further strengthen the results for multiple manuscripts...versus a propagation of energy upwards from small mixing events (e.g., via generation of vo rtices). A key technical goal of our work was to develop...raw waveforms co llected during the LatMix 20 l I airborne lidar surveys, and completion of the analysis and write -up of major results stemming from

Identifying Unidentified Fermi-LAT Objects (UFOs) at High-Latitude

NASA Astrophysics Data System (ADS)

Cheung, Chi Teddy

2009-09-01

We propose a Chandra study of 8 high Galactic latitude gamma-ray sources in the Fermi-LAT bright source list. These sources are currently unidentified, i.e., they are not clearly associated with established classes of gamma-ray emitters like blazars and pulsars. The proposed observations will determine the basic properties (fluxes, positions, hardness ratio/spectra) of all X-ray sources down to a 0.3-10 keV flux limit of 1.5e-14 erg/cm2/s within the Fermi-LAT localization circles. This will enable further follow-up at other wavelengths, with the ultimate goal to reveal the nature of these enigmatic gamma-ray sources.

Cooperation of Antiporter LAT2/CD98hc with Uniporter TAT1 for Renal Reabsorption of Neutral Amino Acids.

PubMed

Vilches, Clara; Boiadjieva-Knöpfel, Emilia; Bodoy, Susanna; Camargo, Simone; López de Heredia, Miguel; Prat, Esther; Ormazabal, Aida; Artuch, Rafael; Zorzano, Antonio; Verrey, François; Nunes, Virginia; Palacín, Manuel

2018-04-02

Background Reabsorption of amino acids (AAs) across the renal proximal tubule is crucial for intracellular and whole organism AA homeostasis. Although the luminal transport step is well understood, with several diseases caused by dysregulation of this process, the basolateral transport step is not understood. In humans, only cationic aminoaciduria due to malfunction of the basolateral transporter y + LAT1/CD98hc (SLC7A7/SLC3A2), which mediates the export of cationic AAs, has been described. Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear. Functional cooperation between TAT1 and LAT2/CD98hc has been suggested by in vitro studies but has not been evaluated in vivo Methods To study the functional relationship of TAT1 and LAT2/CD98hc in vivo , we generated a double-knockout mouse model lacking TAT1 and LAT2, the catalytic subunit of LAT2/CD98hc (dKO LAT2-TAT1 mice). Results Compared with mice lacking only TAT1 or LAT2, dKO LAT2-TAT1 mice lost larger amounts of aromatic and other neutral AAs in their urine due to a tubular reabsorption defect. Notably, dKO mice also displayed decreased tubular reabsorption of cationic AAs and increased expression of y + LAT1/CD98hc. Conclusions The LAT2/CD98hc and TAT1 transporters functionally cooperate in vivo , and y + LAT1/CD98hc may compensate for the loss of LAT2/CD98hc and TAT1, functioning as a neutral AA exporter at the expense of some urinary loss of cationic AAs. Cooperative and compensatory mechanisms of AA transporters may explain the lack of basolateral neutral aminoacidurias in humans. Copyright © 2018 by the American Society of Nephrology.

Cap and trade schemes on waste management: a case study of the landfill allowance trading scheme (LATS) in England.

PubMed

Calaf-Forn, Maria; Roca, Jordi; Puig-Ventosa, Ignasi

2014-05-01

The Landfill Allowance Trading Scheme (LATS) is one of the main instruments used in England to enforce the landfill diversion targets established in the Directive 1999/31/EC of the European Parliament and of the Council of 26 April 1999 on the landfill of waste (Landfill Directive). Through the LATS, biodegradable municipal waste (BMW) allowances for landfilling are allocated to each local authority, otherwise known as waste disposal authorities (WDAs). The quantity of landfill allowances received is expected to decrease continuously from 2005/06 to 2019/20 so as to meet the objectives of the Landfill Directive. To achieve their commitments, WDAs can exchange, buy, sell or transfer allowances among each other, or may re-profile their own allocation through banking and/or borrowing. Despite the goals for the first seven years - which included two target years (2005/06 and 2009/10) - being widely achieved (the average allocation of allowances per WDA was 22.9% higher than those finally used), market activity among WDAs was high and prices were not very stable. Results in terms of waste reduction and recycling levels have been satisfactory. The reduction of BMW landfilled (in percentage) was higher during the first seven years of the LATS period (2005/06-2011/12) (around 7% annually) than during the previous period (2001/02-2004/05) (4.2% annually). Since 2008, the significance of the LATS diminished because of an increase in the rate of the UK Landfill Tax. The LATS was suppressed after the 2012/13 target year, before what it was initially scheduled. The purpose of this paper is to describe the particularities of the LATS, analyse its performance as a waste management policy, make a comparison with the Landfill Tax, discuss its main features as regards efficiency, effectiveness and the application of the "polluter pays" principle and finally discuss if the effect of the increase in the Landfill Tax is what made the LATS ultimately unnecessary. Copyright © 2014

Fermi-LAT Gamma-Ray Bursts and Insights from Swift

NASA Technical Reports Server (NTRS)

Racusin, Judith L.

2010-01-01

A new revolution in Gamma-ray Burst (GRB) observations and theory has begun over the last two years since the launch of the Fermi Gamma-ray Space Telescope. The new window into high energy gamma-rays opened by the Fermi-Large Area Telescope (LAT) is providing insight into prompt emission mechanisms and possibly also afterglow physics. The LAT detected GRBs appear to be a new unique subset of extremely energetic and bright bursts compared to the large sample detected by Swift over the last 6 years. In this talk, I will discuss the context and recent discoveries from these LAT GRBs and the large database of broadband observations collected by the Swift X-ray Telescope (XRT) and UV/Optical Telescope (UVOT). Through comparisons between the GRBs detected by Swift-BAT, G8M, and LAT, we can learn about the unique characteristics, physical differences, and the relationships between each population. These population characteristics provide insight into the different physical parameters that contribute to the diversity of observational GRB properties.

Fermi-LAT Search for Pulsar Wind Nebulae around gamma-ray Pulsars

DOE PAGES

Ackermann, M.; Ajello, M.; Baldini, L.; ...

2010-12-13

The high sensitivity of the Fermi-LAT (Large Area Telescope) offers the first opportunity to study faint and extended GeV sources such as pulsar wind nebulae (PWNe). After one year of observation the LAT detected and identified three PWNe: the Crab Nebula, Vela-X, and the PWN inside MSH 15-52. In the meantime, the list of LAT detected pulsars increased steadily. These pulsars are characterized by high energy loss rates (more » $$\\dot{E}$$) from ~3 × 10 33 erg s –1 to 5 × 10 38 erg s –1 and are therefore likely to power a PWN. This paper summarizes the search for PWNe in the off-pulse windows of 54 LAT-detected pulsars using 16 months of survey observations. Ten sources show significant emission, seven of these likely being of magnetospheric origin. The detection of significant emission in the off-pulse interval offers new constraints on the γ-ray emitting regions in pulsar magnetospheres. The three other sources with significant emission are the Crab Nebula, Vela-X, and a new PWN candidate associated with the LAT pulsar PSR J1023–5746, coincident with the TeV source HESS J1023–575. Here, we further explore the association between the HESS and the Fermi source by modeling its spectral energy distribution. Lastly, flux upper limits derived for the 44 remaining sources are used to provide new constraints on famous PWNe that have been detected at keV and/or TeV energies.« less

Observation and Simulations of the Backsplash Effects in High-Energy Gamma-Ray Telescopes Containing a Massive Calorimeter

NASA Technical Reports Server (NTRS)

Moiseev, Alexander A.; Ormes, Jonathan F.; Hartman, Robert C.; Johnson, Thomas E.; Mitchell, John W.; Thompson, David J.

1999-01-01

Beam test and simulation results are presented for a study of the backsplash effects produced in a high-energy gamma-ray detector containing a massive calorimeter. An empirical formula is developed to estimate the probability (per unit area) of backsplash for different calorimeter materials and thicknesses, different incident particle energies, and at different distances from the calorimeter. The results obtained are applied to the design of Anti-Coincidence Detector (ACD) for the Large Area Telescope (LAT) on the Gamma-ray Large Area Space Telescope (GLAST).

Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways

PubMed Central

Ma, Biao; Cheng, Hongcheng; Gao, Ruize; Mu, Chenglong; Chen, Ling; Wu, Shian; Chen, Quan; Zhu, Yushan

2016-01-01

The evolutionarily conserved Hippo pathway is a regulator that controls organ size, cell growth and tissue homeostasis. Upstream signals of the Hippo pathway have been widely studied, but how microenvironmental factors coordinately regulate this pathway remains unclear. In this study, we identify LIM domain protein Zyxin, as a scaffold protein, that in response to hypoxia and TGF-β stimuli, forms a ternary complex with Lats2 and Siah2 and stabilizes their interaction. This interaction facilitates Lats2 ubiquitination and degradation, Yap dephosphorylation and subsequently activation. We show that Zyxin is required for TGF-β and hypoxia-induced Lats2 downregulation and deactivation of Hippo signalling in MDA-MB-231 cells. Depletion of Zyxin impairs the capability of cell migration, proliferation and tumourigenesis in a xenograft model. Zyxin is upregulated in human breast cancer and positively correlates with histological stages and metastasis. Our study demonstrates that Zyxin-Lats2–Siah2 axis may serve as a potential therapeutic target in cancer treatment. PMID:27030211

Reliable Genetic Labeling of Adult-Born Dentate Granule Cells Using Ascl1 CreERT2 and Glast CreERT2 Murine Lines.

PubMed

Yang, Sung M; Alvarez, Diego D; Schinder, Alejandro F

2015-11-18

Newly generated dentate granule cells (GCs) are relevant for input discrimination in the adult hippocampus. Yet, their precise contribution to information processing remains unclear. To address this question, it is essential to develop approaches to precisely label entire cohorts of adult-born GCs. In this work, we used genetically modified mice to allow conditional expression of tdTomato (Tom) in adult-born GCs and characterized their development and functional integration. Ascl1(CreERT2);CAG(floxStopTom) and Glast(CreERT2);CAG(floxStopTom) mice resulted in indelible expression of Tom in adult neural stem cells and their lineage upon tamoxifen induction. Whole-cell recordings were performed to measure intrinsic excitability, firing behavior, and afferent excitatory connectivity. Developing GCs were also staged by the expression of early and late neuronal markers. The slow development of adult-born GCs characterized here is consistent with previous reports using retroviral approaches that have revealed that a mature phenotype is typically achieved after 6-8 weeks. Our findings demonstrate that Ascl1(CreERT2) and Glast(CreERT2) mouse lines enable simple and reliable labeling of adult-born GC lineages within restricted time windows. Therefore, these mice greatly facilitate tagging new neurons and manipulating their activity, required for understanding adult neurogenesis in the context of network remodeling, learning, and behavior. Our study shows that Ascl1(CreERT2) and Glast(CreERT2) mice lines can be used to label large cohorts of adult-born dentate granule cells with excellent time resolution. Neurons labeled in this manner display developmental and functional profiles that are in full agreement with previous findings using thymidine analogs and retroviral labeling, thus providing an alternative approach to tackle fundamental questions on circuit remodeling. Because of the massive neuronal targeting and the simplicity of this method, genetic labeling will

Five Years of the Fermi LAT Flare Advocate

NASA Astrophysics Data System (ADS)

Carpenter, Bryce; Ojha, R.; Gasparrini, D.; Ciprini, S.; Fermi LAT Collaboration; Fermi LAT Flare Advocates

2014-01-01

Since the launch of the Fermi satellite, the Fermi Large Area Telescope (LAT) team has run a program that provides a daily review of the the gamma-ray sky as soon as Fermi LAT data becomes available. The Flare Advocate/Gamma-ray Sky Watcher (FA-GSW) program allows a rapid analysis of the Automatic Science Processing (ASP) products and triggers dedicated followup analyses by several LAT science groups such as those studying Galactic transients, extragalactic sources and new gamma-ray sources. Significant gamma-ray detections also trigger rapid communications to the entire astrophysical community via astronomical telegrams and gamma-ray coordination network notices. The FA-GSW program plays a key role in maximizing the science return from Fermi by increasing the rate of multi-frequency observations of sources in an active gamma-ray state. In the past ~5 years blazar flaring activity of varying strength and duty cycles, gravitationally lensed blazars, flares from Galactic sources (like Nova Delphini and the Crab Nebula), unidentified transients near and off the Galactic plane, and emission from the quiet and flaring Sun, represent the range of detections made. Flare Advocates have published about 250 Astronomical Telegrams and they publish a weekly blog. Timely, extensive multi-frequency campaigns have been organized to follow-up on these phenomena leading to some of Fermi’s most interesting results.

Influence of Herpes Simplex Virus Latency-Associated Transcript (LAT) on the Distribution of Latently Infected Neurons

DTIC Science & Technology

2007-03-20

part of my life, who knows more about herpesviruses than any 8-year-old should, for making me tea and snacks when I was studying or writing, for...of latency (2, 13, 36, 45, 76, 77, 81). However, HSV-2 LAT has not been shown to inhibit apoptosis of neuronal cells. HSV has several anti ...apoptotic genes, including ICP27, ICP22, US3, US5, ICP4, and HSV-1 LAT (4). Only LAT is expressed during latency, suggesting that its anti -apoptotic

Study of the boxlike dark matter signals from dwarf spheroidal galaxies with Fermi-LAT data

NASA Astrophysics Data System (ADS)

Li, Shang; Liang, Yun-Feng; Xia, Zi-Qing; Zu, Lei; Duan, Kai-Kai; Shen, Zhao-Qiang; Feng, Lei; Yuan, Qiang; Fan, Yi-Zhong

2018-04-01

The observation of a special spectral feature in the gamma-ray data would be one of the best ways to identify dark matter (DM). The box-shaped gamma-ray spectra could be generated by the decay of intermediate particles produced by DM annihilation or decay. It provides another kind of signal that can be relatively easily distinguished from astrophysical backgrounds besides the linelike signals. Dwarf spheroidal galaxies are expected to be dominated by DM and may be one of the most promising targets for indirect DM searches. In this paper, we study the box-shaped DM signals with Fermi-LAT observations of dwarf spheroidal galaxies. We analyze 106 months of Fermi-LAT data to derive the upper limits on the annihilation cross section or the decay timescale of DM. In addition, we compare the results for different sample selections and DM density distributions. We expect that more dwarf spheroidal galaxies will be found and the sensitivity of box-shaped gamma-ray signal searches will be significantly improved in the future.

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

PubMed

Ylikangas, Henna; Malmioja, Kalle; Peura, Lauri; Gynther, Mikko; Nwachukwu, Emmanuel O; Leppänen, Jukka; Laine, Krista; Rautio, Jarkko; Lahtela-Kakkonen, Maija; Huttunen, Kristiina M; Poso, Antti

2014-12-01

L-Type amino acid transporter 1 (LAT1) is a transmembrane protein expressed abundantly at the blood-brain barrier (BBB), where it ensures the transport of hydrophobic acids from the blood to the brain. Due to its unique substrate specificity and high expression at the BBB, LAT1 is an intriguing target for carrier-mediated transport of drugs into the brain. In this study, a comparative molecular field analysis (CoMFA) model with considerable statistical quality (Q(2) =0.53, R(2) =0.75, Q(2) SE=0.77, R(2) SE=0.57) and good external predictivity (CCC=0.91) was generated. The model was used to guide the synthesis of eight new prodrugs whose affinity for LAT1 was tested by using an in situ rat brain perfusion technique. This resulted in the creation of a novel LAT1 prodrug with L-tryptophan as the promoiety; it also provided a better understanding of the molecular features of LAT1-targeted high-affinity prodrugs, as well as their promoiety and parent drug. The results obtained will be beneficial in the rational design of novel LAT1-binding prodrugs and other compounds that bind to LAT1. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1.

PubMed

Singh, Natesh; Ecker, Gerhard F

2018-04-24

The large neutral amino acid transporter 1 (LAT1, or SLC7A5) is a sodium- and pH-independent transporter, which supplies essential amino acids (e.g., leucine, phenylalanine) to cells. It plays an important role at the Blood⁻Brain Barrier (BBB) where it facilitates the transport of thyroid hormones, pharmaceuticals (e.g., l-DOPA, gabapentin), and metabolites into the brain. Moreover, its expression is highly upregulated in various types of human cancer that are characterized by an intense demand for amino acids for growth and proliferation. Therefore, LAT1 is believed to be an important drug target for cancer treatment. With the crystallization of the arginine/agmatine antiporter (AdiC) from Escherichia Coli , numerous homology models of LAT1 have been built to elucidate the substrate binding site, ligand⁻transporter interaction, and structure⁻function relationship. The use of these models in combination with molecular docking and experimental testing has identified novel chemotypes of ligands of LAT1. Here, we highlight the structure, function, transport mechanism, and homology modeling of LAT1. Additionally, results from structure⁻function studies performed on LAT1 are addressed, which have enhanced our knowledge of the mechanism of substrate binding and translocation. This is followed by a discussion on ligand- and structure-based approaches, with an emphasis on elucidating the molecular basis of LAT1 inhibition. Finally, we provide an exhaustive summary of different LAT1 inhibitors that have been identified so far, including the recently discovered irreversible covalent inhibitors.

Monitoring the Low-Energy Gamma-Ray Sky Using Earth Occultation with GLAST GBM

NASA Technical Reports Server (NTRS)

Case, G.; Wilson-Hodge, C.; Cherry, M.; Kippen, M.; Ling, J.; Radocinski, R.; Wheaton, W.

2007-01-01

Long term all-sky monitoring of the 20 keV - 2 MeV gamma-ray sky using the Earth occultation technique was demonstrated by the BATSE instrument on the Compton Gamma Ray Observatory. The principles and techniques used for the development of an end-to-end earth occultation data analysis system for BATSE can be extended to the GLAST Gamma-ray Burst Monitor (GBM), resulting in multiband light curves and time-resolved spectra in the energy range 8 keV to above 1 MeV for known gamma-ray sources and transient outbursts, as well as the discovery of new sources of gamma-ray emission. In this paper we describe the application of the technique to the GBM. We also present the expected sensitivity for the GBM.

2FHL: The Second Catalog of Hard Fermi-LAT Sources

DOE PAGES

Ackermann, M.; Ajello, M.; Atwood, W. B.; ...

2016-01-14

We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (LAT) in 80 months of data. The newly delivered Pass 8 event-level analysis allows the detection and characterization of sources in the 50 GeV–2TeV energy range. In this energy band, Fermi - LAT has detected 360 sources, which constitute the second catalog of hard Fermi -LAT sources (2FHL). The improved angular resolution enables the precise localization of point sources (~1.'7 radius at 68 % C. L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associatedmore » with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHL sources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi -LAT on orbit and the observations performed at higher energies by Cherenkov telescopes from the ground.« less

2FHL- The Second Catalog of Hard Fermi-LAT Sources

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Gonzalez, J. Becerra; Bellazzini, R.; Bissaldi, E.;

2FHL: The Second Catalog of Hard Fermi-LAT Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Atwood, W. B.

We present a catalog of sources detected above 50 GeV by the Fermi-Large Area Telescope (LAT) in 80 months of data. The newly delivered Pass 8 event-level analysis allows the detection and characterization of sources in the 50 GeV–2TeV energy range. In this energy band, Fermi - LAT has detected 360 sources, which constitute the second catalog of hard Fermi -LAT sources (2FHL). The improved angular resolution enables the precise localization of point sources (~1.'7 radius at 68 % C. L.) and the detection and characterization of spatially extended sources. We find that 86% of the sources can be associatedmore » with counterparts at other wavelengths, of which the majority (75%) are active galactic nuclei and the rest (11%) are Galactic sources. Only 25% of the 2FHL sources have been previously detected by Cherenkov telescopes, implying that the 2FHL provides a reservoir of candidates to be followed up at very high energies. This work closes the energy gap between the observations performed at GeV energies by Fermi -LAT on orbit and the observations performed at higher energies by Cherenkov telescopes from the ground.« less

LatMix 2011 and 2012 Dispersion Analysis

DTIC Science & Technology

2015-09-30

work included the airborne lidar operations as well as a substantial part of the field operations and analysis. A primary objective of our LatMix... lidar ) surveys of evolving dye experiments as a tool for studying submesoscale lateral dispersion. 2 Numerous papers by our group relating to the...drifter / lidar effort, however, there are additional aspects of the data and analysis that are beyond the scope of these already-in-progress

Digging for the Truth: Photon Archeology with GLAST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stecker, F. W.

2007-07-12

Stecker, Malkan and Scully, have shown how ongoing deep surveys of galaxy luminosity functions, spectral energy distributions and backwards evolution models of star formation rates can be used to calculate the past history of intergalactic photon densities for energies from 0.03 eV to the Lyman limit at 13.6 eV and for redshifts out to 6 (called here the intergalactic background light or IBL). From these calculations of the IBL at various redshifts, they predict the present and past optical depth of the universe to high energy {gamma}-rays owing to interactions with photons of the IBL and the 2.7 K CMB.more » We discuss here how this proceedure can be reversed by looking for sharp cutoffs in the spectra of extragalactic {gamma}-ray sources such as blazars at high redshifts in the multi-GeV energy range with GLAST (Gamma-Ray Large Are Space Telescope). By determining the cutoff energies of sources with known redshifts, we can refine our determination of the IBL photon densities in the past, i.e., the archeo-IBL, and therefore get a better measure of the past history of the total star formation rate. Conversely, observations of sharp high energy cutoffs in the {gamma}-ray spectra of sources at unknown redshifts can be used instead of spectral lines to give a measure of their redshifts.« less

Theoretical Interpretation of Pass 8 Fermi -LAT e + + e - Data

DOE PAGES

Di Mauro, M.; Manconi, S.; Vittino, A.; ...

2017-08-17

The flux of positrons and electrons (e + + e -) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. Here, we discuss a number of interpretations of Pass 8 Fermi-LAT e + + e - spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We also found that the Fermi-LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and amore » secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e + + e - Fermi-LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green's catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e + + e - Fermi-LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e + + e -spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

Theoretical Interpretation of Pass 8 Fermi -LAT e + + e - Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Mauro, M.; Manconi, S.; Vittino, A.

The flux of positrons and electrons (e + + e -) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. Here, we discuss a number of interpretations of Pass 8 Fermi-LAT e + + e - spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We also found that the Fermi-LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positrons from cataloged PWNe, and amore » secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e + + e - Fermi-LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green's catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e + + e - Fermi-LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e + + e -spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

Fermi LAT Stacking Analysis of Swift Localized GRBs

DOE PAGES

Ackermann, M.; Ajello, M.; Anderson, B.; ...

2016-05-05

In this paper, we perform a comprehensive stacking analysis of data collected by the Fermi Large Area Telescope (LAT) of γ-ray bursts (GRBs) localized by the Swift spacecraft, which were not detected by the LAT but which fell within the instrument's field of view at the time of trigger. We examine a total of 79 GRBs by comparing the observed counts over a range of time intervals to that expected from designated background orbits, as well as by using a joint likelihood technique to model the expected distribution of stacked counts. We find strong evidence for subthreshold emission at MeVmore » to GeV energies using both techniques. This observed excess is detected during intervals that include and exceed the durations typically characterizing the prompt emission observed at keV energies and lasts at least 2700 s after the co-aligned burst trigger. By utilizing a novel cumulative likelihood analysis, we find that although a burst's prompt γ-ray and afterglow X-ray flux both correlate with the strength of the subthreshold emission, the X-ray afterglow flux measured by Swift's X-ray Telescope at 11 hr post trigger correlates far more significantly. Overall, the extended nature of the subthreshold emission and its connection to the burst's afterglow brightness lend further support to the external forward shock origin of the late-time emission detected by the LAT. Finally, these results suggest that the extended high-energy emission observed by the LAT may be a relatively common feature but remains undetected in a majority of bursts owing to instrumental threshold effects.« less

NuLat: A Novel Design for a Reactor Anti-Neutrino Detector

NASA Astrophysics Data System (ADS)

Rountree, S. Derek; NuLat Collaboration

2015-04-01

NuLat is a proposed very-short baseline (3-10m) reactor electron antineutrino (anti-νe) experiment that will probe the current best fit for light sterile neutrino mixing, the 5 MeV excess seen in current short baseline reactor experiments, and serve as a portable surface detector for cooperative (~ 30m baseline) surface monitoring of reactors. The NuLat detector will use an optically segmented 3D Raghavan optical lattice (ROL) detector that channels light via total internal reflection from a scintillation event down the 3 primary axes to the detector faces. The high degree of segmentation allows for each voxel's energy to be determined independently of other voxels, thus providing high temporal and spatial resolution and energy reconstruction independent of position. NuLat detects anti-νe via inverse beta decay (IBD), which produces a positron and a neutron. Most of the time, the positron deposits its kinetic energy into a single voxel allowing superior derivation of the incident anti-νe's energy. The final state neutron is captured via (n, α) on 6 Li or 10 B after a characteristic delay time giving a coincidence tag. This talk will discuss the physics reach of NuLat using a solid loaded scintillator, and the timeline of the NuLat reactor anti-νe program. This research has been funded in part by the National Science Foundation on Award Numbers 1001394 and 1001078.

LatY136F knock-in mouse model for human IgG4-related disease.

PubMed

Yamada, Kazunori; Zuka, Masahiko; Ito, Kiyoaki; Mizuguchi, Keishi; Kakuchi, Yasushi; Onoe, Tamehito; Suzuki, Yasunori; Yamagishi, Masakazu; Izui, Shozo; Malissen, Marie; Malissen, Bernard; Kawano, Mitsuhiro

2018-01-01

The adaptor protein Linker for activation of T cell (LAT) is a key signaling hub used by the T cell antigen receptor. Mutant mice expressing loss-of-function mutations affecting LAT and including a mutation in which tyrosine 136 is replaced by a phenylalanine (LatY136F) develop lymphoproliferative disorder involving T helper type 2 effector cells capable of triggering a massive polyclonal B cell activation that leads to hypergammaglobulinemia G1 and E and to non-resolving inflammation and autoimmunity. The purpose of this study was to evaluate whether the phenotypes of LatY136F knock-in mice resemble the immunohistopathological features of immunoglobulin G4-related disease (IgG4-RD). LatY136F knock-in mice were sacrificed at 4-20 weeks of age, and pancreas, kidney, salivary gland and lung were obtained. All organs were stained with hematoxylin-eosin and with Azan for estimation of collagen in fibrosis, and the severity scores of inflammation and fibrosis were evaluated. Immunostainings were performed to analyze the types of infiltrating cells. In addition, the effects of corticosteroid treatment on the development of tissue lesions and serum levels of IgG1 were assessed. Tissue lesions characterized by inflammatory mononuclear cell infiltration and fibrosis were detected in pancreas, kidney, and salivary gland starting from 6 weeks of age. Immunostainings showed pronounced infiltration of plasma cells, CD4-positive T cells, and macrophages. Infiltrating plasma cells predominantly expressed IgG1. The extent of inflammation in pancreas and salivary glands was markedly reduced by corticosteroid treatment. LatY136F knock-in mice displayed increased production of Th2-type IgG1 (a homologue of human IgG4) and developed multiple organ tissue lesions reminiscent of those seen in patients with IgG4-RD. Moreover, the development of these tissue lesions was highly sensitive to corticosteroid treatment like in IgG4-RD. For these reasons we consider the LatY136F knock-in mouse

Latency-Associated Transcript (LAT) Exon 1 Controls Herpes Simplex Virus Species-Specific Phenotypes: Reactivation in the Guinea Pig Genital Model and Neuron Subtype-Specific Latent Expression of LAT▿

PubMed Central

Bertke, Andrea S.; Patel, Amita; Imai, Yumi; Apakupakul, Kathleen; Margolis, Todd P.; Krause, Philip R.

2009-01-01

Herpes simplex virus 1 (HSV-1) and HSV-2 cause similar acute infections but differ in their abilities to reactivate from trigeminal and lumbosacral dorsal root ganglia. During latency, HSV-1 and HSV-2 also preferentially express their latency-associated transcripts (LATs) in different sensory neuronal subtypes that are positive for A5 and KH10 markers, respectively. Chimeric virus studies showed that LAT region sequences influence both of these viral species-specific phenotypes. To further map the LAT region sequences responsible for these phenotypes, we constructed the chimeric virus HSV2-LAT-E1, in which exon 1 (from the LAT TATA to the intron splice site) was replaced by the corresponding sequence from HSV-1 LAT. In intravaginally infected guinea pigs, HSV2-LAT-E1 reactivated inefficiently relative to the efficiency of its rescuant and wild-type HSV-2, but it yielded similar levels of viral DNA, LAT, and ICP0 during acute and latent infection. HSV2-LAT-E1 preferentially expressed the LAT in A5+ neurons (as does HSV-1), while the chimeric viruses HSV2-LAT-P1 (LAT promoter swap) and HSV2-LAT-S1 (LAT sequence swap downstream of the promoter) exhibited neuron subtype-specific latent LAT expression phenotypes more similar to that of HSV-2 than that of HSV-1. Rescuant viruses displayed the wild-type HSV-2 phenotypes of efficient reactivation in the guinea pig genital model and a tendency to express LAT in KH10+ neurons. The region that is critical for HSV species-specific differences in latency and reactivation thus lies between the LAT TATA and the intron splice site, and minor differences in the 5′ ends of chimeric sequences in HSV2-LAT-E1 and HSV2-LAT-S1 point to sequences immediately downstream of the LAT TATA. PMID:19641003

Blazar Duty-Cycle at Gamma-Ray Frequecies: Constraints From Extragalactic Background Radiation And Prospects for AGILE And GLAST

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pittori, Carlotta; Cavazzuti, Elisabetta; Colafrancesco, Sergio

2011-11-29

We take into account the constraints from the observed extragalactic {gamma}-ray background to estimate the maximum duty cycle allowed for a selected sample of WMAP Blazars, in order to be detectable by AGILE and GLAST {gamma}-ray experiments. For the nominal sensitivity values of both instruments, we identify a subset of sources which can in principle be detectable also in a steady state without over-predicting the extragalactic background. This work is based on the results of a recently derived Blazar radio LogN-LogS obtained by combining several multi-frequency surveys.

Cerebral Cortex Hyperthyroidism of Newborn Mct8-Deficient Mice Transiently Suppressed by Lat2 Inactivation

PubMed Central

Núñez, Bárbara; Martínez de Mena, Raquel; Obregon, Maria Jesus; Font-Llitjós, Mariona; Nunes, Virginia; Palacín, Manuel; Dumitrescu, Alexandra M.; Morte, Beatriz; Bernal, Juan

2014-01-01

Thyroid hormone entry into cells is facilitated by transmembrane transporters. Mutations of the specific thyroid hormone transporter, MCT8 (Monocarboxylate Transporter 8, SLC16A2) cause an X-linked syndrome of profound neurological impairment and altered thyroid function known as the Allan-Herndon-Dudley syndrome. MCT8 deficiency presumably results in failure of thyroid hormone to reach the neural target cells in adequate amounts to sustain normal brain development. However during the perinatal period the absence of Mct8 in mice induces a state of cerebral cortex hyperthyroidism, indicating increased brain access and/or retention of thyroid hormone. The contribution of other transporters to thyroid hormone metabolism and action, especially in the context of MCT8 deficiency is not clear. We have analyzed the role of the heterodimeric aminoacid transporter Lat2 (Slc7a8), in the presence or absence of Mct8, on thyroid hormone concentrations and on expression of thyroid hormone-dependent cerebral cortex genes. To this end we generated Lat2-/-, and Mct8-/yLat2 -/- mice, to compare with wild type and Mct8-/y mice during postnatal development. As described previously the single Mct8 KO neonates had a transient increase of 3,5,3′-triiodothyronine concentration and expression of thyroid hormone target genes in the cerebral cortex. Strikingly the absence of Lat2 in the double Mct8Lat2 KO prevented the effect of Mct8 inactivation in newborns. The Lat2 effect was not observed from postnatal day 5 onwards. On postnatal day 21 the Mct8 KO displayed the typical pattern of thyroid hormone concentrations in plasma, decreased cortex 3,5,3′-triiodothyronine concentration and Hr expression, and concomitant Lat2 inactivation produced little to no modifications. As Lat2 is expressed in neurons and in the choroid plexus, the results support a role for Lat2 in the supply of thyroid hormone to the cerebral cortex during early postnatal development. PMID:24819605

Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.

PubMed

Núñez, Bárbara; Martínez de Mena, Raquel; Obregon, Maria Jesus; Font-Llitjós, Mariona; Nunes, Virginia; Palacín, Manuel; Dumitrescu, Alexandra M; Morte, Beatriz; Bernal, Juan

2014-01-01

Thyroid hormone entry into cells is facilitated by transmembrane transporters. Mutations of the specific thyroid hormone transporter, MCT8 (Monocarboxylate Transporter 8, SLC16A2) cause an X-linked syndrome of profound neurological impairment and altered thyroid function known as the Allan-Herndon-Dudley syndrome. MCT8 deficiency presumably results in failure of thyroid hormone to reach the neural target cells in adequate amounts to sustain normal brain development. However during the perinatal period the absence of Mct8 in mice induces a state of cerebral cortex hyperthyroidism, indicating increased brain access and/or retention of thyroid hormone. The contribution of other transporters to thyroid hormone metabolism and action, especially in the context of MCT8 deficiency is not clear. We have analyzed the role of the heterodimeric aminoacid transporter Lat2 (Slc7a8), in the presence or absence of Mct8, on thyroid hormone concentrations and on expression of thyroid hormone-dependent cerebral cortex genes. To this end we generated Lat2-/-, and Mct8-/yLat2-/- mice, to compare with wild type and Mct8-/y mice during postnatal development. As described previously the single Mct8 KO neonates had a transient increase of 3,5,3'-triiodothyronine concentration and expression of thyroid hormone target genes in the cerebral cortex. Strikingly the absence of Lat2 in the double Mct8Lat2 KO prevented the effect of Mct8 inactivation in newborns. The Lat2 effect was not observed from postnatal day 5 onwards. On postnatal day 21 the Mct8 KO displayed the typical pattern of thyroid hormone concentrations in plasma, decreased cortex 3,5,3'-triiodothyronine concentration and Hr expression, and concomitant Lat2 inactivation produced little to no modifications. As Lat2 is expressed in neurons and in the choroid plexus, the results support a role for Lat2 in the supply of thyroid hormone to the cerebral cortex during early postnatal development.

Search for Spatially Extended Fermi-LAT Sources Using Two Years of Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lande, Joshua; Ackermann, Markus; Allafort, Alice

2012-07-13

Spatial extension is an important characteristic for correctly associating {gamma}-ray-emitting sources with their counterparts at other wavelengths and for obtaining an unbiased model of their spectra. We present a new method for quantifying the spatial extension of sources detected by the Large Area Telescope (LAT), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi). We perform a series of Monte Carlo simulations to validate this tool and calculate the LAT threshold for detecting the spatial extension of sources. We then test all sources in the second Fermi -LAT catalog (2FGL) for extension. We report the detection of sevenmore » new spatially extended sources.« less

LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.

PubMed

Strazisar, Mojca; Mlakar, Vid; Glavac, Damjan

2009-06-01

LATS2 is a new member of the LATS tumour suppressor family. The human LATS2 gene is located at chromosome 13q11-12, a hot spot (67%) for loss of heterozygosity (LOH) in non-small cell lung cancer (NSCLC). We screened 129 non-small cell lung cancer samples and 13 lung cancer cell lines, initially for mutations in the LATS2 gene and subsequently for mutations in P53 and K-RAS genes. Either polymorphisms or mutations were identified in over 50 percent of analysed tumours. A novel missense mutation, S1073R, and a large deletion of 8 amino acids in the PAPA-repeat region were detected in 9 and 2 NSCLC tumours, respectively. Those mutations were not identified in the 13 lung cancer cell lines. Mutations were tumour specific and were absent from adjacent normal tissue and healthy controls. Down-regulation of the LATS2 gene was observed in most NSCLC tumours but was not related to any mutation or polymorphism. Tumours with a LATS2 mutation often also harbour a P53 but not K-RAS gene mutation and were mostly in an advanced stage of development, with regional lymph node involvement.

Search for Gamma-Ray Emission from Galactic Novae using Fermi-LAT Pass 8

NASA Astrophysics Data System (ADS)

Buson, Sara; Franckowiak, Anna; Cheung, Teddy; Jean, Pierre; Fermi-LAT Collaboration

2016-01-01

Recently Galactic novae have been identified as a new class of GeV gamma-ray emitters, with 6 detected so far with the Fermi Large Area Telescope (Fermi-LAT) data. Based on optical observations we have compiled a catalog of ~70 Galactic novae, which peak (in optical) during the operations of the Fermi mission. Based on the properties of known gamma-ray novae we developed a search procedure that we apply to all novae in the catalog to detect these slow transient sources or set flux upper limits using the Fermi-LAT Pass 8 data set. This is the first time a large sample of Galactic novae has been uniformly studied.

Trichostatin A down-regulates ZAP-70, LAT and SLP-76 content in Jurkat T cells.

PubMed

Januchowski, Radosław; Jagodzinski, Paweł P

2007-02-01

We exploited Jurkat leukemia T cell clone E6-1 as a model of Trichostatin A (TSA) effect on cellular levels of ZAP-70, LAT and SLP-76 molecules involved in the signal transduction pathway from T cell receptor to nucleus. Using reverse transcription real-time quantitative PCR and Western blotting analysis we observed that TSA resulted in ZAP-70, LAT and SLP-76 transcript and protein down-regulation in Jurkat leukemia T cells. We also found that TSA reduced half-life of ZAP-70, LAT and SLP-76 mRNAs from 4.8, 3.5, and 4.8 to approximately 2.3, 1.9 and 1.7 h, respectively. Employing the protein biosynthesis inhibitor cycloheximide, we demonstrated the involvement of RNase and/or mRNA stabilization protein in ZAP-70, LAT and SLP-76 mRNAs stabilization. The effect of TSA on ZAP-70, LAT and SLP-76 content in T cells confirms an immunosuppressive effect by TSA, and the usefulness of this histone deacetylase inhibitor in the treatment of autoimmune diseases.

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis.

PubMed

Azad, T; Janse van Rensburg, H J; Lightbody, E D; Neveu, B; Champagne, A; Ghaffari, A; Kay, V R; Hao, Y; Shen, H; Yeung, B; Croy, B A; Guan, K L; Pouliot, F; Zhang, J; Nicol, C J B; Yang, X

2018-03-13

The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component LATS kinase. Using this biosensor and a library of small molecule kinase inhibitors, we perform a screen for kinases modulating LATS activity and identify VEGFR as an upstream regulator of the Hippo pathway. We find that VEGFR activation by VEGF triggers PI3K/MAPK signaling, which subsequently inhibits LATS and activates the Hippo effectors YAP and TAZ. We further show that the Hippo pathway is a critical mediator of VEGF-induced angiogenesis and tumor vasculogenic mimicry. Thus, our work offers a biosensor tool for the study of the Hippo pathway and suggests a role for Hippo signaling in regulating blood vessel formation in physiological and pathological settings.

Fermi-LAT upper limits on gamma-ray emission from colliding wind binaries

DOE PAGES

Werner, Michael; Reimer, O.; Reimer, A.; ...

2013-07-09

Here, colliding wind binaries (CWBs) are thought to give rise to a plethora of physical processes including acceleration and interaction of relativistic particles. Observation of synchrotron radiation in the radio band confirms there is a relativistic electron population in CWBs. Accordingly, CWBs have been suspected sources of high-energy γ-ray emission since the COS-B era. Theoretical models exist that characterize the underlying physical processes leading to particle acceleration and quantitatively predict the non-thermal energy emission observable at Earth. Furthermore, we strive to find evidence of γ-ray emission from a sample of seven CWB systems: WR 11, WR 70, WR 125, WRmore » 137, WR 140, WR 146, and WR 147. Theoretical modelling identified these systems as the most favourable candidates for emitting γ-rays. We make a comparison with existing γ-ray flux predictions and investigate possible constraints. We used 24 months of data from the Large Area Telescope (LAT) on-board the Fermi Gamma Ray Space Telescope to perform a dedicated likelihood analysis of CWBs in the LAT energy range. As a result, we find no evidence of γ-ray emission from any of the studied CWB systems and determine corresponding flux upper limits. For some CWBs the interplay of orbital and stellar parameters renders the Fermi-LAT data not sensitive enough to constrain the parameter space of the emission models. In the cases of WR140 and WR147, the Fermi -LAT upper limits appear to rule out some model predictions entirely and constrain theoretical models over a significant parameter space. A comparison of our findings to the CWB η Car is made.« less

The vela pulsar: results from the first year of FERMI lat observations

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2010-03-18

Here, we report on analysis of timing and spectroscopy of the Vela pulsar using 11 months of observations with the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope. The intrinsic brightness of Vela at GeV energies combined with the angular resolution and sensitivity of the LAT allows us to make the most detailed study to date of the energy-dependent light curves and phase-resolved spectra, using a LAT-derived timing model. The light curve consists of two peaks (P1 and P2) connected by bridge emission containing a third peak (P3). We have confirmed the strong decrease of the P1/P2 ratiomore » with increasing energy seen with EGRET and previous Fermi LAT data, and observe that P1 disappears above 20 GeV. The increase with energy of the mean phase of the P3 component can be followed with much greater detail, showing that P3 and P2 are present up to the highest energies of pulsation. We find significant pulsed emission at phases outside the main profile, indicating that magnetospheric emission exists over 80% of the pulsar period. With increased high-energy counts the phase-averaged spectrum is seen to depart from a power law with simple exponential cutoff, and is better fit with a more gradual cutoff. The spectra in fixed-count phase bins are well fit with power laws with exponential cutoffs, revealing a strong and complex phase dependence of the cutoff energy, especially in the peaks. Finally, by combining these results with predictions of the outer magnetosphere models that map emission characteristics to phase, it will be possible to probe the particle acceleration and the structure of the pulsar magnetosphere with unprecedented detail.« less

Cen A Optical Gamma Composite

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 The gamma-ray output from Cen A's lobes exceeds their radio output by more than ten times. High-energy gamma rays detected by Fermi's Large Area Telescope are depicted as purple in this gamma ray/optical composite of the galaxy. Credit: NASA/DOE/Fermi LAT Collaboration, Capella Observatory To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Decreased reactivation of a herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) mutant using the in vivo mouse UV-B model of induced reactivation

PubMed Central

BenMohamed, Lbachir; Osorio, Nelson; Srivastava, Ruchi; Khan, Arif A.; Simpson, Jennifer L.; Wechsler, Steven L.

2015-01-01

Blinding ocular herpetic disease in humans is due to herpes simplex virus type 1 (HSV-1) reactivations from latency, rather than to primary acute infection. The cellular and molecular mechanisms that control the HSV-1 latency-reactivation cycle remain to be fully elucidated. The aim of this study was to determine if reactivation of the HSV-1 latency associated transcript (LAT) deletion mutant (dLAT2903) was impaired in this model, as it is in the rabbit model of induced and spontaneous reactivation and in the explant TG induced reactivation model in mice. The eyes of mice latently infected with wild type HSV-1 strain McKrae (LAT(+) virus) or dLAT2903 (LAT(−) virus) were irradiated with UV-B and reactivation was determined. We found that compared to LAT(−) virus, LAT(+) virus reactivated at a higher rate as determined by shedding of virus in tears on days 3 to 7 after UV-B treatment. Thus, the UV-B induced reactivation model of HSV-1 appears to be a useful small animal model for studying the mechanisms involved in how LAT enhances the HSV-1 reactivation phenotype. The utility of the model for investigating the immune evasion mechanisms regulating the HSV-1 latency/reactivation cycle and for testing the protective efficacy of candidate therapeutic vaccines and drugs are discussed. PMID:26002839

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

DOE PAGES

Ni, Lisheng; Zheng, Yonggang; Hara, Mayuko; ...

2015-06-24

The Mst–Lats kinase cascade is central to the Hippo tumor-suppressive pathway that controls organ size and tissue homeostasis. The adaptor protein Mob1 promotes Lats activation by Mst, but the mechanism remains unknown. Here, we show that human Mob1 binds to autophosphorylated docking motifs in active Mst2. This binding enables Mob1 phosphorylation by Mst2. Phosphorylated Mob1 undergoes conformational activation and binds to Lats1. We determine the crystal structures of phospho-Mst2–Mob1 and phospho-Mob1–Lats1 complexes, revealing the structural basis of both phosphorylation-dependent binding events. Further biochemical and functional analyses demonstrate that Mob1 mediates Lats1 activation through dynamic scaffolding and allosteric mechanisms. Thus, Mob1more » acts as a phosphorylation-regulated coupler of kinase activation by virtue of its ability to engage multiple ligands. We propose that stepwise, phosphorylation-triggered docking interactions of nonkinase elements enhance the specificity and robustness of kinase signaling cascades.« less

Searching for γ-ray emission from Reticulum II by Fermi-LAT

NASA Astrophysics Data System (ADS)

Zhao, Yi; Bi, Xiao-Jun; Yin, Peng-Fei; Zhang, Xinmin

2018-02-01

Recently, many new dwarf spheroidal satellites (dSphs) have been discovered by the Dark Energy Survey (DES). These dSphs are ideal candidates for probing for gamma-ray emissions from dark matter (DM) annihilation. However, no significant signature has been found by the Fermi-LAT dSph observations. In this work, we reanalyze the Fermi-LAT Pass 8 data from the direction of Reticulum II, where a slight excess has been reported by some previous studies. We treat Reticulum II (DES J0335.6-5403) as a spatially extended source, and find that no significant gamma-ray signature is observed. Based on this result, we set upper-limits on the DM annihilation cross section. Supported by National Natural Science Foundation of China (11121092, 11033005, 11375202, 11475191, 11475189), the CAS pilot B program (XDB23020000) and the National Key Program for Research and Development (2016YFA0400200)

miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1.

PubMed

Liu, Shikai; Song, Lili; Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

2015-04-17

Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3'-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. Copyright © 2015 Elsevier Inc. All rights reserved.

Fermi LAT detection of enhanced gamma-ray emission from the Crab Nebula region

NASA Astrophysics Data System (ADS)

Ojha, Roopesh; Buehler, Rolf; Hays, Elizabeth; Dutka, Michael

2012-07-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed a significant increase in the gamma-ray activity from a source positionally consistent with the Crab Nebula on July 3, 2012. Preliminary LAT analysis indicates that the daily-averaged gamma-ray emission (E >100 MeV) from the direction of the Crab doubled from (2.4 +/- 0.5) x 10^-6 ph/cm2/sec (statistical errors only) on July 2nd to (5.5 +/- 0.7) x 10^-6 ph/cm2/sec on July 3rd, a factor of 2 greater than the average flux of (2.75 +/- 0.10) x 10^-6 ph/cm2/sec reported in the second Fermi LAT catalog (2FGL, Nolan et al.

The X-Ray Counterpart to LAT PSR J2021+4026 and Its Interesting Spectrum

NASA Technical Reports Server (NTRS)

Weisskopf, Martin C.; Becker, W.; Carraminana, A.; De Luca, A.; Dormandy, M.; Harding, A.; Kanbach, G.; O'Dell, S. L.; Parkinson, P. Saz; Ray, P.;

miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Shikai; Song, Lili, E-mail: commasll@163.com; Zhang, Liang

Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervicalmore » cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.« less

Fermi LAT detection of a GeV flare from blazar TXS 0943+105

NASA Astrophysics Data System (ADS)

Ciprini, S.

2014-07-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar TXS 0943+105, also known as GB6 J0946+1016, MG1 J094636+1017 and 2FGL J0946.5+1015 in the second Fermi LAT catalog (2FGL, Nolan et al. ...

The Gamma-Ray Albedo of the Moon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, I.V.; /Stanford U., HEPL /KIPAC, Menlo Park; Porter, T.A.

2008-03-25

We use the GEANT4 Monte Carlo framework to calculate the {gamma}-ray albedo of the Moon due to interactions of cosmic ray (CR) nuclei with moon rock. Our calculation of the albedo spectrum agrees with the EGRET data. We show that the spectrum of {gamma}-rays from the Moon is very steep with an effective cutoff around 3-4 GeV (600 MeV for the inner part of the Moon disk) and exhibits a narrow pion-decay line at 67.5 MeV, perhaps unique in astrophysics. Apart from other astrophysical sources, the albedo spectrum of the Moon is well understood, including its absolute normalization; this makesmore » it a useful 'standard candle' for {gamma}-ray telescopes. The steep albedo spectrum also provides a unique opportunity for energy calibration of {gamma}-ray telescopes, such as the forthcoming Gamma Ray Large Area Space Telescope (GLAST). Since the albedo flux depends on the incident CR spectrum which changes over the solar cycle, it is possible to monitor the CR spectrum using the albedo {gamma}-ray flux. Simultaneous measurements of CR proton and helium spectra by the Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics (PAMELA), and observations of the albedo {gamma}-rays by the GLAST Large Area Telescope (LAT), can be used to test the model predictions and will enable the LAT to monitor the CR spectrum near the Earth beyond the lifetime of the PAMELA.« less

The Gamma-ray Albedo of the Moon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moskalenko, Igor V.; /Stanford U., HEPL; Porter, Troy A.

2007-09-28

We use the GEANT4 Monte Carlo framework to calculate the {gamma}-ray albedo of the Moon due to interactions of cosmic ray (CR) nuclei with moon rock. Our calculation of the albedo spectrum agrees with the EGRET data. We show that the spectrum of {gamma}-rays from the Moon is very steep with an effective cutoff around 3-4 GeV (600 MeV for the inner part of the Moon disk) and exhibits a narrow pion-decay line at 67.5 MeV, perhaps unique in astrophysics. Apart from other astrophysical sources, the albedo spectrum of the Moon is well understood, including its absolute normalization; this makesmore » it a useful 'standard candle' for {gamma}-ray telescopes. The steep albedo spectrum also provides a unique opportunity for energy calibration of {gamma}-ray telescopes, such as the forthcoming Gamma Ray Large Area Space Telescope (GLAST). Since the albedo flux depends on the incident CR spectrum which changes over the solar cycle, it is possible to monitor the CR spectrum using the albedo {gamma}-ray flux. Simultaneous measurements of CR proton and helium spectra by the Payload for Antimatter-Matter Exploration and Light-nuclei Astrophysics (PAMELA), and observations of the albedo {gamma}-rays by the GLAST Large Area Telescope (LAT), can be used to test the model predictions and will enable the LAT to monitor the CR spectrum near the Earth beyond the lifetime of the PAMELA.« less

Fermi-LAT View of Bright Flaring Gamma-Ray Blazars

NASA Astrophysics Data System (ADS)

Bastieri, D.; Ciprini, S.; Gasparrini, D.

2011-06-01

The Fermi LAT provides a continuous and uniform monitoring of the Universe in the gamma-ray band. During the first year many gamma-ray blazar flares, some unidentified transients and emission by the Sun while in a quiet state were promptly detected. This is mainly due to the design of the mission, featuring a detector, the LAT with a wide field of view, and to the operation of the spacecraft itself, that can cover every region of the sky every 3 hours. Nevertheless, the scientific exploitation of this monitoring is more fruitful when early information about transients reaches a broader community. In this respect, the indefatigable activity of flare advocates, who worked on weekly shifts to validate the results and quickly broadcast information about flares and new detections, was the key to most scientific results.

Aryl hydrocarbon receptor (AHR) regulation of L-Type Amino Acid Transporter 1 (LAT-1) expression in MCF-7 and MDA-MB-231 breast cancer cells.

PubMed

Tomblin, Justin K; Arthur, Subha; Primerano, Donald A; Chaudhry, Ateeq R; Fan, Jun; Denvir, James; Salisbury, Travis B

2016-04-15

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is regulated by environmental toxicants that function as AHR agonists such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). L-Type Amino Acid Transporter 1 (LAT1) is a leucine transporter that is overexpressed in cancer. The regulation of LAT1 by AHR in MCF-7 and MDA-MB-231 breast cancer cells (BCCs) was investigated in this report. Ingenuity pathway analysis (IPA) revealed a significant association between TCDD-regulated genes (TRGs) and molecular transport. Overlapping the TCDD-RNA-Seq dataset obtained in this study with a published TCDD-ChIP-seq dataset identified LAT1 as a primary target of AHR-dependent TCDD induction. Short interfering RNA (siRNA)-directed knockdown of AHR confirmed that TCDD-stimulated increases in LAT1 mRNA and protein required AHR expression. TCDD-stimulated increases in LAT1 mRNA were also inhibited by the AHR antagonist CH-223191. Upregulation of LAT1 by TCDD coincided with increases in leucine uptake by MCF-7 cells in response to TCDD. Chromatin immunoprecipitation-quantitative PCR (ChIP-qPCR) assays revealed increases in AHR, AHR nuclear translocator (ARNT) and p300 binding and histone H3 acetylation at an AHR binding site in the LAT1 gene in response to TCDD. In MCF-7 and MDA-MB-231 cells, endogenous levels of LAT1 mRNA and protein were reduced in response to knockdown of AHR expression. Knockdown experiments demonstrated that proliferation of MCF-7 and MDA-MB-231 cells is dependent on both LAT1 and AHR. Collectively, these findings confirm the dependence of cancer cells on leucine uptake and establish a mechanism for extrinsic and intrinsic regulation of LAT1 by AHR. Copyright © 2016 Elsevier Inc. All rights reserved.

Detection of 16 gamma-ray pulsars through blind frequency searches using the Fermi LAT.

PubMed

Abdo, A A; Ackermann, M; Ajello, M; Anderson, B; Atwood, W B; Axelsson, M; Baldini, L; Ballet, J; Barbiellini, G; Baring, M G; Bastieri, D; Baughman, B M; Bechtol, K; Bellazzini, R; Berenji, B; Bignami, G F; Blandford, R D; Bloom, E D; Bonamente, E; Borgland, A W; Bregeon, J; Brez, A; Brigida, M; Bruel, P; Burnett, T H; Caliandro, G A; Cameron, R A; Caraveo, P A; Casandjian, J M; Cecchi, C; Celik, O; Chekhtman, A; Cheung, C C; Chiang, J; Ciprini, S; Claus, R; Cohen-Tanugi, J; Conrad, J; Cutini, S; Dermer, C D; de Angelis, A; de Luca, A; de Palma, F; Digel, S W; Dormody, M; do Couto e Silva, E; Drell, P S; Dubois, R; Dumora, D; Farnier, C; Favuzzi, C; Fegan, S J; Fukazawa, Y; Funk, S; Fusco, P; Gargano, F; Gasparrini, D; Gehrels, N; Germani, S; Giebels, B; Giglietto, N; Giommi, P; Giordano, F; Glanzman, T; Godfrey, G; Grenier, I A; Grondin, M-H; Grove, J E; Guillemot, L; Guiriec, S; Gwon, C; Hanabata, Y; Harding, A K; Hayashida, M; Hays, E; Hughes, R E; Jóhannesson, G; Johnson, R P; Johnson, T J; Johnson, W N; Kamae, T; Katagiri, H; Kataoka, J; Kawai, N; Kerr, M; Knödlseder, J; Kocian, M L; Kuss, M; Lande, J; Latronico, L; Lemoine-Goumard, M; Longo, F; Loparco, F; Lott, B; Lovellette, M N; Lubrano, P; Madejski, G M; Makeev, A; Marelli, M; Mazziotta, M N; McConville, W; McEnery, J E; Meurer, C; Michelson, P F; Mitthumsiri, W; Mizuno, T; Monte, C; Monzani, M E; Morselli, A; Moskalenko, I V; Murgia, S; Nolan, P L; Norris, J P; Nuss, E; Ohsugi, T; Omodei, N; Orlando, E; Ormes, J F; Paneque, D; Parent, D; Pelassa, V; Pepe, M; Pesce-Rollins, M; Pierbattista, M; Piron, F; Porter, T A; Primack, J R; Rainò, S; Rando, R; Ray, P S; Razzano, M; Rea, N; Reimer, A; Reimer, O; Reposeur, T; Ritz, S; Rochester, L S; Rodriguez, A Y; Romani, R W; Ryde, F; Sadrozinski, H F-W; Sanchez, D; Sander, A; Saz Parkinson, P M; Scargle, J D; Sgrò, C; Siskind, E J; Smith, D A; Smith, P D; Spandre, G; Spinelli, P; Starck, J-L; Strickman, M S; Suson, D J; Tajima, H; Takahashi, H; Takahashi, T; Tanaka, T; Thayer, J G; Thompson, D J; Tibaldo, L; Tibolla, O; Torres, D F; Tosti, G; Tramacere, A; Uchiyama, Y; Usher, T L; Van Etten, A; Vasileiou, V; Vilchez, N; Vitale, V; Waite, A P; Wang, P; Watters, K; Winer, B L; Wolff, M T; Wood, K S; Ylinen, T; Ziegler, M

2009-08-14

Pulsars are rapidly rotating, highly magnetized neutron stars emitting radiation across the electromagnetic spectrum. Although there are more than 1800 known radio pulsars, until recently only seven were observed to pulse in gamma rays, and these were all discovered at other wavelengths. The Fermi Large Area Telescope (LAT) makes it possible to pinpoint neutron stars through their gamma-ray pulsations. We report the detection of 16 gamma-ray pulsars in blind frequency searches using the LAT. Most of these pulsars are coincident with previously unidentified gamma-ray sources, and many are associated with supernova remnants. Direct detection of gamma-ray pulsars enables studies of emission mechanisms, population statistics, and the energetics of pulsar wind nebulae and supernova remnants.

THE FIRST FERMI LAT SUPERNOVA REMNANT CATALOG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Acero, F.; Ballet, J.; Ackermann, M.

2016-05-01

To uniformly determine the properties of supernova remnants (SNRs) at high energies, we have developed the first systematic survey at energies from 1 to 100 GeV using data from the Fermi Large Area Telescope (LAT). Based on the spatial overlap of sources detected at GeV energies with SNRs known from radio surveys, we classify 30 sources as likely GeV SNRs. We also report 14 marginal associations and 245 flux upper limits. A mock catalog in which the positions of known remnants are scrambled in Galactic longitude allows us to determine an upper limit of 22% on the number of GeV candidates falsely identifiedmore » as SNRs. We have also developed a method to estimate spectral and spatial systematic errors arising from the diffuse interstellar emission model, a key component of all Galactic Fermi LAT analyses. By studying remnants uniformly in aggregate, we measure the GeV properties common to these objects and provide a crucial context for the detailed modeling of individual SNRs. Combining our GeV results with multiwavelength (MW) data, including radio, X-ray, and TeV, we demonstrate the need for improvements to previously sufficient, simple models describing the GeV and radio emission from these objects. We model the GeV and MW emission from SNRs in aggregate to constrain their maximal contribution to observed Galactic cosmic rays.« less

Search For Dark Matter Satellites Using Fermi-Lat

DOE PAGES

Ackermann, M.

2012-02-23

Numerical simulations based on the ΛCDM model of cosmology predict a large number of as yet unobserved Galactic dark matter satellites. We report the results of a Large Area Telescope (LAT) search for these satellites via the γ-ray emission expected from the annihilation of weakly interacting massive particle (WIMP) dark matter. Some dark matter satellites are expected to have hard γ-ray spectra, finite angular extents, and a lack of counterparts at other wavelengths. We sought to identify LAT sources with these characteristics, focusing on γ-ray spectra consistent with WIMP annihilation through themore » $$b \\bar{b}$$ channel. We found no viable dark matter satellite candidates using one year of data, and we present a framework for interpreting this result in the context of numerical simulations to constrain the velocity-averaged annihilation cross section for a conventional 100 GeV WIMP annihilating through the $$b \\bar{b}$$ channel.« less

An Analysis Methodology for the Gamma-ray Large Area Space Telescope

NASA Technical Reports Server (NTRS)

Morris, Robin D.; Cohen-Tanugi, Johann

2004-01-01

The Large Area Telescope (LAT) instrument on the Gamma Ray Large Area Space Telescope (GLAST) has been designed to detect high-energy gamma rays and determine their direction of incidence and energy. We propose a reconstruction algorithm based on recent advances in statistical methodology. This method, alternative to the standard event analysis inherited from high energy collider physics experiments, incorporates more accurately the physical processes occurring in the detector, and makes full use of the statistical information available. It could thus provide a better estimate of the direction and energy of the primary photon.

Pulsar timing for the Fermi gamma-ray space telescope

DOE PAGES

Smith, D. A.; Guillemot, L.; Camilo, F.; ...

2008-10-27

Here, we describe a comprehensive pulsar monitoring campaign for the Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope (formerly GLAST). The detection and study of pulsars in gamma rays give insights into the populations of neutron stars and supernova rates in the Galaxy, into particle acceleration mechanisms in neutron star magnetospheres, and into the “engines” driving pulsar wind nebulae. LAT's unprecedented sensitivity between 20 MeV and 300 GeV together with its 2.4 sr field-of-view makes detection of many gamma-ray pulsars likely, justifying the monitoring of over two hundred pulsars with large spin-down powers. To search for gamma-ray pulsationsmore » from most of these pulsars requires a set of phase-connected timing solutions spanning a year or more to properly align the sparse photon arrival times. We describe the choice of pulsars and the instruments involved in the campaign. Attention is paid to verifications of the LAT pulsar software, using for example giant radio pulses from the Crab and from PSR B1937+21 recorded at Nançay, and using X-ray data on PSR J0218+4232 from XMM-Newton. We demonstrate accuracy of the pulsar phase calculations at the microsecond level.« less

East Pacific Rise at lat 19°S: Evidence for a recent ridge jump

NASA Astrophysics Data System (ADS)

Morton, Janet L.; Ballard, Robert D.

1986-02-01

A detailed ANGUS (Acoustically Navigated Geological Undersea Surveyor) photographic and bathymetric survey of the East Pacific Rise (EPR) near lat 19°S reveals a small jump of the ridge axis to the west. The axial block in this region consists of two parallel ridges 3 km apart and separated by a 200-m-deep valley. South of lat 19°06‧S the plate boundary is a single, narrow (<1 km) ridge. The eastern ridge near lat 19°S is shallower than the western ridge and is morphologically a continuation of the narrow, active ridge axis to the south. ANGUS photographs along both ridges and in the intervening valley, however, show that the western ridge is the currently active plate boundary. We suggest that spreading shifted westward from the eastern ridge to its present position within the past 40 000 yr. The EPR in the general region has been characterized by asymmetric spreading for the past 2.4 m.y. The sense of the ridge jump near lat 19°S is consistent with the asymmetric spreading, which could have been produced by a series of such jumps.

NRAO Teams With NASA Gamma-Ray Satellite

NASA Astrophysics Data System (ADS)

2007-06-01

The National Radio Astronomy Observatory (NRAO) is teaming with NASA's upcoming Gamma-ray Large Area Space Telescope (GLAST) to allow astronomers to use both the orbiting facility and ground-based radio telescopes to maximize their scientific payoff. Under the new, streamlined process, astronomers can compete for coordinated observing time and support from both GLAST and NRAO's radio telescopes. GLAST satellite Artist's rendering of the GLAST spacecraft in orbit above the Earth. CREDIT: General Dynamics C4 Systems Click on Image for Larger File Images of NRAO Telescopes Robert C. Byrd Green Bank Telescope Very Long Baseline Array Very Large Array Atacama Large Millimeter/submillimeter Array GLAST is scheduled for launch no earlier than December 14. It will perform a survey of the entire sky at gamma-ray wavelengths every 3 hours using its primary instrument, the Large Area Telescope (LAT). NRAO operates the Very Large Array (VLA) in New Mexico, the continent-wide Very Long Baseline Array (VLBA), and the Robert C. Byrd Green Bank Telescope (GBT) in West Virginia. The NRAO is a research facility of the National Science Foundation (NSF). "Coordinated gamma-ray and radio observations of celestial objects will greatly enhance the ability to fully understand those objects. Astronomy today requires such multiwavelength studies, and this agreement paves the way for exciting, cutting-edge research," said Fred K.Y. Lo, NRAO Director. GLAST will be vastly more capable than previous gamma-ray satellites, and will carry an instrument, the GLAST Burst Monitor, specifically designed to detect gamma-ray bursts. GLAST observers will study objects such as active galaxies, pulsars, and supernova remnants, which are also readily studied with radio telescopes. By working together, NASA's GLAST mission and NSF's NRAO facilities can study flares from blazars over the widest possible range of energies, which is crucial to understanding how black holes, notorious for drawing matter in, can

Theoretical Interpretation of Pass 8 Fermi -LAT e {sup +} + e {sup −} Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Mauro, M.; Manconi, S.; Donato, F.

The flux of positrons and electrons ( e {sup +} + e {sup −}) has been measured by the Fermi Large Area Telescope (LAT) in the energy range between 7 GeV and 2 TeV. We discuss a number of interpretations of Pass 8 Fermi -LAT e {sup +} + e {sup −} spectrum, combining electron and positron emission from supernova remnants (SNRs) and pulsar wind nebulae (PWNe), or produced by the collision of cosmic rays (CRs) with the interstellar medium. We find that the Fermi -LAT spectrum is compatible with the sum of electrons from a smooth SNR population, positronsmore » from cataloged PWNe, and a secondary component. If we include in our analysis constraints from the AMS-02 positron spectrum, we obtain a slightly worse fit to the e {sup +} + e {sup −} Fermi -LAT spectrum, depending on the propagation model. As an additional scenario, we replace the smooth SNR component within 0.7 kpc with the individual sources found in Green’s catalog of Galactic SNRs. We find that separate consideration of far and near sources helps to reproduce the e {sup +} + e {sup −} Fermi -LAT spectrum. However, we show that the fit degrades when the radio constraints on the positron emission from Vela SNR (which is the main contributor at high energies) are taken into account. We find that a break in the power-law injection spectrum at about 100 GeV can also reproduce the measured e {sup +} + e {sup −} spectrum and, among the CR propagation models that we consider, no reasonable break of the power-law dependence of the diffusion coefficient can modify the electron flux enough to reproduce the observed shape.« less

Detection of 16 Gamma-Ray Pulsars Through Blind Frequency Searches Using the Fermi LAT

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2009-07-02

Pulsars are rapidly rotating, highly magnetized neutron stars emitting radiation across the electromagnetic spectrum. Although there are more than 1800 known radio pulsars, until recently only seven were observed to pulse in gamma rays, and these were all discovered at other wavelengths. The Fermi Large Area Telescope (LAT) makes it possible to pinpoint neutron stars through their gamma-ray pulsations. In this paper, we report the detection of 16 gamma-ray pulsars in blind frequency searches using the LAT. Most of these pulsars are coincident with previously unidentified gamma-ray sources, and many are associated with supernova remnants. Finally, direct detection of gamma-raymore » pulsars enables studies of emission mechanisms, population statistics, and the energetics of pulsar wind nebulae and supernova remnants.« less

Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.

PubMed

Myers, Darienne R; Lau, Tannia; Markegard, Evan; Lim, Hyung W; Kasler, Herbert; Zhu, Minghua; Barczak, Andrea; Huizar, John P; Zikherman, Julie; Erle, David J; Zhang, Weiguo; Verdin, Eric; Roose, Jeroen P

2017-05-23

CD4 + T cells differentiate into T helper cell subsets in feedforward manners with synergistic signals from the T cell receptor (TCR), cytokines, and lineage-specific transcription factors. Naive CD4 + T cells avoid spontaneous engagement of feedforward mechanisms but retain a prepared state. T cells lacking the adaptor molecule LAT demonstrate impaired TCR-induced signals yet cause a spontaneous lymphoproliferative T helper 2 (T H 2) cell syndrome in mice. Thus, LAT constitutes an unexplained maintenance cue. Here, we demonstrate that tonic signals through LAT constitutively export the repressor HDAC7 from the nucleus of CD4 + T cells. Without such tonic signals, HDAC7 target genes Nur77 and Irf4 are repressed. We reveal that Nur77 suppresses CD4 + T cell proliferation and uncover a suppressive role for Irf4 in T H 2 polarization; halving Irf4 gene-dosage leads to increases in GATA3 + and IL-4 + cells. Our studies reveal that naive CD4 + T cells are dynamically tuned by tonic LAT-HDAC7 signals. Published by Elsevier Inc.

Search for Dark Matter Satellites Using the Fermi-Lat

NASA Technical Reports Server (NTRS)

Ackermann, M.; Albert, A.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bloom, E. D.;

Tectonic significance of magnetic and gravity data across northern California (lat. 39[degree]N. to lat. 41[degree]N. )

DOE Office of Scientific and Technical Information (OSTI.GOV)

Griscom, A.; Roberts, C.W.; Halvorson, P.F.

1993-04-01

Aeromagnetic and isostatic residual gravity maps of an east-west transect across northern California show important tectonic features. A linear magnetic anomaly and west-sloping gradient extends over 300 km along the Franciscan-Great Valley contact (FGC) and across the Klamath Mountains province (KM) north to lat. 40[degree]45'N. The anomaly source lies at depths of 5--10 km beneath the KM and the FGC, and implies that the Franciscan complex of the Coast Ranges is thrust (and wedged) at least 80 km eastward beneath the KM to approximately long. 122[degree]40 minutes W. Calculations on a circular gravity low of [minus]50 mGal centered at themore » circular Bald Rock pluton (diameter about 15 km) in the Sierran foothills indicate a pluton thickness of about 15 km. The nearby Cascade and Merrimac plutons are located on the gradients of this gravity anomaly, have a relatively minor effect on it, and thus are interpreted to be thick (up to 5 km) laccolithic sills that emanate from the Bald Rock pluton, thinning away from it to a feather edge. Model studies indicate that the northeast contact of the Feather River periodotite body (FRPB) north of lat. 39[degree]40 minutes N. generally dips steeply northeast or vertical. The same contact south of this latitude dips east at angles of about 45[degree] to depths of at least 10 km. Magnetic patterns extending from the northern Sierra across the Cascades to the Klamath Mountains suggest that the FRPB may correlate with the Trinity ophiolite.« less

Fermi-LAT Gamma-Ray Detections of Classical Novae V1369 Centauri 2013 and V5668 Sagittarii 2015

NASA Astrophysics Data System (ADS)

Cheung, C. C.; Jean, P.; Shore, S. N.; Stawarz, Ł.; Corbet, R. H. D.; Knödlseder, J.; Starrfield, S.; Wood, D. L.; Desiante, R.; Longo, F.; Pivato, G.; Wood, K. S.

2016-08-01

We report the Fermi Large Area Telescope (LAT) detections of high-energy (>100 MeV) γ-ray emission from two recent optically bright classical novae, V1369 Centauri 2013 and V5668 Sagittarii 2015. At early times, Fermi target-of-opportunity observations prompted by their optical discoveries provided enhanced LAT exposure that enabled the detections of γ-ray onsets beginning ˜2 days after their first optical peaks. Significant γ-ray emission was found extending to 39-55 days after their initial LAT detections, with systematically fainter and longer-duration emission compared to previous γ-ray-detected classical novae. These novae were distinguished by multiple bright optical peaks that encompassed the time spans of the observed γ-rays. The γ-ray light curves and spectra of the two novae are presented along with representative hadronic and leptonic models, and comparisons with other novae detected by the LAT are discussed.

Fermi -LAT Observations of High-energy Behind-the-limb Solar Flares

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Buehler, R.; Allafort, A.

2017-02-01

We report on the Fermi -LAT detection of high-energy emission from the behind-the-limb (BTL) solar flares that occurred on 2013 October 11, and 2014 January 6 and September 1. The Fermi -LAT observations are associated with flares from active regions originating behind both the eastern and western limbs, as determined by STEREO . All three flares are associated with very fast coronal mass ejections (CMEs) and strong solar energetic particle events. We present updated localizations of the >100 MeV photon emission, hard X-ray (HXR) and EUV images, and broadband spectra from 10 keV to 10 GeV, as well as microwavemore » spectra. We also provide a comparison of the BTL flares detected by Fermi -LAT with three on-disk flares and present a study of some of the significant quantities of these flares as an attempt to better understand the acceleration mechanisms at work during these occulted flares. We interpret the HXR emission to be due to electron bremsstrahlung from a coronal thin-target loop top with the accelerated electron spectra steepening at semirelativistic energies. The >100 MeV gamma-rays are best described by a pion-decay model resulting from the interaction of protons (and other ions) in a thick-target photospheric source. The protons are believed to have been accelerated (to energies >10 GeV) in the CME environment and precipitate down to the photosphere from the downstream side of the CME shock and landed on the front side of the Sun, away from the original flare site and the HXR emission.« less

Fermi-LAT Observations of High-energy Behind-the-limb Solar Flares

DOE PAGES

Ackermann, M.; Allafort, A.; Baldini, L.; ...

2017-01-31

In this paper, we report on the Fermi-LAT detection of high-energy emission from the behind-the-limb (BTL) solar flares that occurred on 2013 October 11, and 2014 January 6 and September 1. The Fermi-LAT observations are associated with flares from active regions originating behind both the eastern and western limbs, as determined by STEREO. All three flares are associated with very fast coronal mass ejections (CMEs) and strong solar energetic particle events. We present updated localizations of the >100 MeV photon emission, hard X-ray (HXR) and EUV images, and broadband spectra from 10 keV to 10 GeV, as well as microwavemore » spectra. We also provide a comparison of the BTL flares detected by Fermi-LAT with three on-disk flares and present a study of some of the significant quantities of these flares as an attempt to better understand the acceleration mechanisms at work during these occulted flares. We interpret the HXR emission to be due to electron bremsstrahlung from a coronal thin-target loop top with the accelerated electron spectra steepening at semirelativistic energies. The >100 MeV gamma-rays are best described by a pion-decay model resulting from the interaction of protons (and other ions) in a thick-target photospheric source. In conclusion, the protons are believed to have been accelerated (to energies >10 GeV) in the CME environment and precipitate down to the photosphere from the downstream side of the CME shock and landed on the front side of the Sun, away from the original flare site and the HXR emission.« less

Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.

PubMed

Milewski, Krzysztof; Bogacińska-Karaś, Małgorzata; Fręśko, Inez; Hilgier, Wojciech; Jaźwiec, Radosław; Albrecht, Jan; Zielińska, Magdalena

2017-11-02

Previously we had shown that ammonia stimulates nitric oxide (NO) synthesis in astrocytes by increasing the uptake of the precursor amino acid, arginine via the heteromeric arginine/glutamine transporter y⁺LAT2. Ammonia also increases the concentration in the brain of the endogenous inhibitor of nitric oxide synthases (NOS), asymmetric dimethylarginine (ADMA), but distribution of ADMA surplus between the intraastrocytic and extracellular compartments of the brain has not been studied. Here we tested the hypothesis that ammonia modulates the distribution of ADMA and its analog symmetric dimethylarginine (SDMA) between the two compartments of the brain by competition with arginine for the y⁺LAT2 transporter. In extension of the hypothesis we analyzed the ADMA/Arg interaction in endothelial cells forming the blood-brain barrier. We measured by high-performance liquid chromatography (HPLC) and mass spectrometry (MS) technique the concentration of arginine, ADMA and SDMA in cultured cortical astrocytes and in a rat brain endothelial cell line (RBE-4) treated with ammonia and the effect of silencing the expression of a gene coding y⁺LAT2. We also tested the expression of ADMA metabolism enzymes: protein arginine methyltransferase (PRMT) and dimethylarginine dimethyl aminohydrolase (DDAH) and arginine uptake to astrocytes. Treatment for 48 h with 5 mM ammonia led to an almost 50% reduction of ADMA and SDMA concentration in both cell types, and the effect in astrocytes was substantially attenuated by silencing of the Slc7a6 gene. Moreover, the y⁺LAT2-dependent component of ammonia-evoked arginine uptake in astrocytes was reduced in the presence of ADMA in the medium. Our results suggest that increased ADMA efflux mediated by upregulated y⁺LAT2 may be a mechanism by which ammonia interferes with intra-astrocytic (and possibly intra-endothelial cell) ADMA content and subsequently, NO synthesis in both cell types.

Tycho's Star Shines in Gamma Rays

NASA Image and Video Library

2017-12-08

NASA image relase December 13, 2011 Gamma-rays detected by Fermi's LAT show that the remnant of Tycho's supernova shines in the highest-energy form of light. This portrait of the shattered star includes gamma rays (magenta), X-rays (yellow, green, and blue), infrared (red) and optical data. Credit: Gamma ray, NASA/DOE/Fermi LAT Collaboration; X-ray, NASA/CXC/SAO; Infrared, NASA/JPL-Caltech; Optical, MPIA, Calar Alto, O. Krause et al. and DSS To read more go to: www.nasa.gov/mission_pages/GLAST/news/tycho-star.html NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

miR-107 and miR-25 simultaneously target LATS2 and regulate proliferation and invasion of gastric adenocarcinoma (GAC) cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Mingjun; Wang, Xiaolei; Li, Wanhu

Although a series of oncogenes and tumor suppressors were identified in the pathological development of gastric adenocarcinoma (GAC), the underlying molecule mechanism were still not fully understood. The current study explored the expression profile of miR-107 and miR-25 in GAC patients and their downstream regulative network. qRT-PCR analysis was performed to quantify the expression of these two miRNAs in serum samples from both patients and healthy controls. Dual luciferase assay was conducted to verify their putative bindings with LATS2. MTT assay, cell cycle assay and transwell assay were performed to explore how miR-107 and miR-25 regulate proliferation and invasion ofmore » gastric cancer cells. Findings of this study demonstrated that total miR-107 or miR-25 expression might be overexpressed in gastric cancer patients and they can simultaneously and synchronically regulate LATS2 expression, thereby affecting gastric cancer cell growth and invasion. Therefore, the miR-25/miR-107-LATS2 axis might play an important role in proliferation and invasion of the gastric cancer cells. - Highlights: • Total miR-107 and miR-25 expression is significantly increased in GAC patients. • Both miR-107 and miR-25 can promote proliferation and invasion of GAC cells. • Both miR-107 and miR-25 can target LATS2 and regulate its expression. • miR-107 and miR-25 regulate proliferation and invasion of GAC cells though LATS2.« less

Fermi-LAT gamma ray detections of classical novae V1369 centauri 2013 and V5668 Sagittarii 2015

DOE PAGES

Cheung, C. C.; Jean, P.; Shore, S. N.; ...

2016-07-27

Here, we report the Fermi Large Area Telescope (LAT) detections of high-energy (>100 MeV) γ-ray emission from two recent optically bright classical novae, V1369 Centauri 2013 and V5668 Sagittarii 2015. Furthermore, at early times, Fermi target-of-opportunity observations prompted by their optical discoveries provided enhanced LAT exposure that enabled the detections of γ-ray onsets beginning ~2 days after their first optical peaks. Significant γ-ray emission was found extending to 39–55 days after their initial LAT detections, with systematically fainter and longer-duration emission compared to previous γ-ray-detected classical novae. These novae were distinguished by multiple bright optical peaks that encompassed the timemore » spans of the observed γ-rays. Finally, we discussed the γ-ray light curves and spectra of the two novae are presented along with representative hadronic and leptonic models, and comparisons with other novae detected by the LAT.« less

Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo.

PubMed

Kalia, Neena; Auger, Jocelyn M; Atkinson, Ben; Watson, Steve P

2008-05-01

The role of collagen receptor complex GPVI-FcR gamma-chain, PLCgamma2 and LAT in laser-induced thrombosis is unclear. Controversy surrounds whether collagen is exposed in this model or whether thrombosis is dependent on thrombin. This study hypothesized that collagen exposure plays a critical role in thrombus formation in this model, which was tested by investigating contributions of FcR gamma-chain, LAT, PLCgamma2 and thrombin. Thrombi were monitored using intravital microscopy in anesthetized wild-type and FcR gamma-chain, LAT and PLCgamma2 knockout mice. Hirudin (thrombin inhibitor) was administered to wild-type and FcR gamma-chain knockout mice. Significantly reduced thrombus formation was observed in FcR gamma-chain and PLCgamma2 knockouts with a greater decrease observed in LAT knockouts. Dramatic reduction was observed in wild-types treated with hirudin, with abolished thrombus formation only observed in FcR gamma-chain knockouts treated with hirudin. GPVI-FcR gamma-chain, LAT and PLCgamma2 are essential for thrombus generation and stability in this laser-induced model of injury. More importantly, a greater role for LAT was identified, which may reflect a role for it downstream of a second matrix protein receptor. However, inhibition of platelet activation by matrix proteins and thrombin generation are both required to maximally prevent thrombus formation.

Anisotropies in the diffuse gamma-ray background from dark matter with Fermi LAT: A closer look

DOE PAGES

Cuoco, A.; Sellerholm, A.; Conrad, J.; ...

2011-06-21

We perform a detailed study of the sensitivity to the anisotropies related to dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) as measured by the Fermi Large Area Telescope ( Fermi LAT). For the first time, we take into account the effects of the Galactic foregrounds and use a realistic representation of the Fermi LAT. We implement an analysis pipeline which simulates Fermi LAT data sets starting from model maps of the Galactic foregrounds, the Fermi-resolved point sources, the extragalactic diffuse emission and the signal from DM annihilation. The effects of the detector are taken into account bymore » convolving the model maps with the Fermi LAT instrumental response. We then use the angular power spectrum to characterize the anisotropy properties of the simulated data and to study the sensitivity to DM. We consider DM anisotropies of extragalactic origin and of Galactic origin (which can be generated through annihilation in the Milky Way substructures) as opposed to a background of anisotropies generated by sources of astrophysical origin, blazars for example. We find that with statistics from 5 yr of observation, Fermi is sensitive to a DM contribution at the level of 1–10 per cent of the measured IGRB depending on the DM mass m χ and annihilation mode. In terms of the thermally averaged cross-section , this corresponds to ~10 –25 cm 3 s –1, i.e. slightly above the typical expectations for a thermal relic, for low values of the DM mass m χ≲ 100 GeV. As a result, the anisotropy method for DM searches has a sensitivity comparable to the usual methods based only on the energy spectrum and thus constitutes an independent and complementary piece of information in the DM puzzle.« less

Fermi-LAT Gamma-ray Observations of Nova Lupus 2016 (ASASSN-16kt)

NASA Astrophysics Data System (ADS)

Cheung, C. C.; Jean, P.; Shore, S. N.; Fermi Large Area Telescope Collaboration

2016-10-01

The Fermi Gamma-ray Space Telescope performed a ~6-day Target of Opportunity (ToO) observation of Nova Lupus 2016 (ATel #9538, #9539, CBET #4322) that commenced on September 28. Considering earlier all-sky survey Large Area Telescope (LAT) observations as well, preliminary analysis indicates gamma-ray emission at ~2 sigma was detected around 1 to 2 days after the optical peak on September 25th (pre-validated AAVSO visual lightcurve; ATel #9550, CBET #4322) when the optical spectra show opaque ejecta, similar to previous gamma-ray detected novae (Fermi-LAT collaboration, 2014 Science 345, 554; Cheung et al. 2016 ApJ 826, 142).

The Fermi Large Area Telescope: Optimizing and Then Re-Optimizing the Science Return

NASA Astrophysics Data System (ADS)

Atwood, W. B.

2012-01-01

The general concepts of how to do gamma-ray observations in space were well established and vetted by the early 1990's. In particular, the success of EGRET onboard the Compton Gamma Ray Observatory whetted the appetite for a more ambitious follow on. In parallel, advances in high-energy particle detection, spurred on by plans for the Superconducting Super Collider, provided an unprecedented opportunity for space-based detectors. The GLAST concept, now Fermi-LAT, was born at SLAC in May of 1992 and the instrument was subsequently developed by an international collaboration from France, Italy, Japan, Sweden and the United States. An overview of the original design optimization of the LAT instrument, done with the goal of imposing as few limits as possible on its applications in space, is discussed (along with some of the trials and tribulations of construction along the way to launch!). Now with over 3 years of science operations experience, the lessons-learned will be reviewed and assessed against the expectations. Finally, the ongoing re-optimization of the instrument and plans for how to extend the LAT's science window into the future are discussed.

SUZAKU X-RAY FOLLOW-UP OBSERVATIONS OF SEVEN UNASSOCIATED FERMI-LAT GAMMA-RAY SOURCES AT HIGH GALACTIC LATITUDES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takahashi, Y.; Kataoka, J.; Nakamori, T.

2012-03-01

We report on our second-year campaign of X-ray follow-up observations of unidentified Fermi Large Area Telescope (LAT) {gamma}-ray sources at high Galactic latitudes (|b| > 10 Degree-Sign ) using the X-ray Imaging Spectrometer on board the Suzaku X-ray Observatory. In this second year of the project, seven new targets were selected from the First Fermi-LAT Catalog, and studied with 20-40 ks effective Suzaku exposures. We detected an X-ray point source coincident with the position of the recently discovered millisecond pulsar (MSP) PSR J2302+4442 within the 95% confidence error circle of 1FGL J2302.8+4443. The X-ray spectrum of the detected counterpart wasmore » well fit by a blackbody model with temperature of kT {approx_equal} 0.3 keV, consistent with an origin of the observed X-ray photons from the surface of a rotating magnetized neutron star. For four other targets that were also recently identified with a normal pulsar (1FGL J0106.7+4853) and MSPs (1FGL J1312.6+0048, J1902.0-5110, and J2043.2+1709), only upper limits in the 0.5-10 keV band were obtained at the flux levels of {approx_equal} 10{sup -14} erg cm{sup -2} s{sup -1}. A weak X-ray source was found in the field of 1FGL J1739.4+8717, but its association with the variable {gamma}-ray emitter could not be confirmed with the available Suzaku data alone. For the remaining Fermi-LAT object 1FGL J1743.8-7620 no X-ray source was detected within the LAT 95% error ellipse. We briefly discuss the general properties of the observed high Galactic-latitude Fermi-LAT objects by comparing their multiwavelength properties with those of known blazars and MSPs.« less

Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy.

PubMed

Li, Lin; Di, Xingsheng; Wu, Mingrui; Sun, Zhisu; Zhong, Lu; Wang, Yongjun; Fu, Qiang; Kan, Qiming; Sun, Jin; He, Zhonggui

2017-04-01

Designing active targeting nanocarriers with increased cellular accumulation of chemotherapeutic agents is a promising strategy in cancer therapy. Herein, we report a novel active targeting strategy based on the large amino acid transporter 1 (LAT1) overexpressed in a variety of cancers. Glutamate was conjugated to polyoxyethylene stearate as a targeting ligand to achieve LAT1-targeting PLGA nanoparticles. The targeting efficiency of nanoparticles was investigated in HeLa and MCF-7 cells. Significant increase in cellular uptake and cytotoxicity was observed in LAT1-targeting nanoparticles compared to the unmodified ones. More interestingly, the internalized LAT1 together with targeting nanoparticles could recycle back to the cell membrane within 3 h, guaranteeing sufficient transporters on cell membrane for continuous cellular uptake. The LAT1 targeting nanoparticles exhibited better tumor accumulation and antitumor effects. These results suggested that the overexpressed LAT1 on cancer cells holds a great potential to be a high-efficiency target for the rational design of active-targeting nanosystems. Copyright © 2016 Elsevier Inc. All rights reserved.

Fermi-LAT observation of nonblazar AGNs

NASA Astrophysics Data System (ADS)

Sahakyan, N.; Baghmanyan, V.; Zargaryan, D.

2018-06-01

Context. Fermi Large Area Telescope (Fermi-LAT) has recently detected γ-ray emission from active galactic nuclei (AGN) that do not show clear evidence for optical blazar characteristics or have jets pointing away from the observer (nonblazar AGNs). These are interesting γ-ray emitters providing an alternative approach to studying high energy emission processes. Aims: This paper investigates the spectral and temporal properties of γ-ray emission from nonblazar AGNs using the recent Fermi-LAT observational data. Methods: The data collected by Fermi-LAT during 2008-2015, from the observations of 26 nonblazar AGNs, including 11 Fanaroff-Riley Type I (FRI) and ten FRII radio galaxies and steep spectrum radio quasars (SSRQs) and five narrow line seyfert 1s (NLSy1s) are analysed using the new PASS 8 event selection and instrument response function. Possible spectral changes above GeV energies are investigated with a detailed spectral analysis. Light curves generated with normal and adaptive time bins are used to study the γ-ray flux variability. Results: Non-blazar AGNs have a γ-ray photon index in the range of 1.84-2.86 and a flux varying from a few times 10-9 photon cm-2 s-1 to 10-7 photon cm-2 s-1. Over long time periods, the power law provides an adequate description of the γ-ray spectra of almost all sources. Significant curvature is observed in the γ-ray spectra of NGC 1275, NGC 6251, SBS 0846 + 513, and PMN J0948 + 0022 and their spectra are better described by log parabola or by the power law with exponential cut-off models. The γ-ray spectra of PKS 0625-25 and 3C 380 show a possible deviation from a simple power-law shape, indicating a spectral cut-off around the observed photon energy of Ecut = 131.2 ± 88.04 GeV and Ecut = 55.57 ± 50.74 GeV, respectively. Our analysis confirms the previous finding of an unusual spectral turnover in the γ-ray spectrum of Cen A: the photon index changes from Γ = 2.75 ± 0.02 to 2.31 ± 0.1 at 2.35 ± 0.08 GeV. In the �

Fermi LAT detection of a GeV flare from blazar S5 1217+71

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2013-03-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar S5 1217+71, also known as TXS 1217+713 and 2FGL J1219.2+7107 in the second Fermi LAT catalog (2FGL, Nolan et al. 2012, ApJS, 199, 31) with VLBI coordinates, (J2000.0), R.A: 185.015118 deg, Dec.: +71.091981 deg (Petrov et al.

Fermi-LAT kills dark matter interpretations of AMS-02 data. Or not?

NASA Astrophysics Data System (ADS)

Belotsky, Konstantin; Budaev, Ruslan; Kirillov, Alexander; Laletin, Maxim

2017-01-01

A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as we show, any rational DM model explaining the positron anomaly abundantly produces final state radiation and Inverse Compton gamma rays, which inevitably leads to a contradiction with Fermi-LAT isotropic diffuse gamma-ray background measurements. Furthermore, the Fermi-LAT observation of Milky Way dwarf satellites, supposed to be rich in DM, revealed no significant signal in gamma rays. We propose a generic approach in which the major contribution to cosmic rays comes from the dark matter disc and prove that the tension between the DM origin of the positron anomaly and the cosmic gamma-ray observations can be relieved. We consider both a simple model, in which DM decay/annihilate into charged leptons, and a model-independent minimal case of particle production, and we estimate the optimal thickness of DM disk. Possible mechanisms of formation and its properties are briefly discussed.

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1▿

PubMed Central

Allen, Sariah J.; Hamrah, Pedram; Gate, David; Mott, Kevin R.; Mantopoulos, Dimosthenis; Zheng, Lixin; Town, Terrence; Jones, Clinton; von Andrian, Ulrich H.; Freeman, Gordon J.; Sharpe, Arlene H.; BenMohamed, Lbachir; Ahmed, Rafi; Wechsler, Steven L.; Ghiasi, Homayon

2011-01-01

Herpes simplex virus (HSV) infection is a classic example of latent viral infection in humans and experimental animal models. The HSV-1 latency-associated transcript (LAT) plays a major role in the HSV-1 latency reactivation cycle and thus in recurrent disease. Whether the presence of LAT leads to generation of dysfunctional T cell responses in the trigeminal ganglia (TG) of latently infected mice is not known. To address this issue, we used LAT-positive [LAT(+)] and LAT-deficient [LAT(−)] viruses to evaluate the effect of LAT on CD8 T cell exhaustion in TG of latently infected mice. The amount of latency as determined by quantitative reverse transcription-PCR (qRT-PCR) of viral DNA in total TG extracts was 3-fold higher with LAT(+) than with LAT(−) virus. LAT expression and increased latency correlated with increased mRNA levels of CD8, PD-1, and Tim-3. PD-1 is both a marker for exhaustion and a primary factor leading to exhaustion, and Tim-3 can also contribute to exhaustion. These results suggested that LAT(+) TG contain both more CD8+ T cells and more CD8+ T cells expressing the exhaustion markers PD-1 and Tim-3. This was confirmed by flow cytometry analyses of expression of CD3/CD8/PD-1/Tim-3, HSV-1, CD8+ T cell pentamer (specific for a peptide derived from residues 498 to 505 of glycoprotein B [gB498–505]), interleukin-2 (IL-2), and tumor necrosis factor alpha (TNF-α). The functional significance of PD-1 and its ligands in HSV-1 latency was demonstrated by the significantly reduced amount of HSV-1 latency in PD-1- and PD-L1-deficient mice. Together, these results may suggest that both PD-1 and Tim-3 are mediators of CD8+ T cell exhaustion and latency in HSV-1 infection. PMID:21307196

Electromyographic analysis of three different types of lat pull-down.

PubMed

Sperandei, Sandro; Barros, Marcos A P; Silveira-Júnior, Paulo C S; Oliveira, Carlos G

2009-10-01

The purpose of this work was to evaluate the activity of the primary motor muscles during the performance of 3 lat pull-down techniques through surface electromyography (EMG). Twenty-four trained adult men performed 5 repetitions of behind-the-neck (BNL), front-of-the-neck (FNL), and V-bar exercises at 80% of 1 repetition maximum. For each technique, the root mean square from the EMG signal was registered from the pectoralis major (PM), latissimus dorsi (LD), posterior deltoid (PD), and biceps brachii (BB) and further normalized in respect to that which presented the highest value of all the techniques. A series of two-way repeated measures analysis of variance was used to compare the results, with Tukey-Kramer as the post hoc test and alpha = 0.05. During the concentric phase, PM value showed the FNL to be significantly higher than V-bar/BNL and V-bar higher than BNL. During the eccentric phase, FNL/V-bar was higher than BNL. For LD, there was no difference between techniques. PD presented BNL higher than FNL/V-bar and FNL higher than V-bar in the concentric phase and BNL higher than V-bar in the eccentric phase. BB exhibited BNL higher than V-bar/FNL and V-bar higher than FNL in both concentric and eccentric phases. Considering the main objectives of lat pull-down, we concluded that FNL is the better choice, whereas BNL is not a good lat pull-down technique and should be avoided. V-bar could be used as an alternative.

Seven-year Collection of Well-monitored Fermi-LAT Gamma-Ray Burst Afterglows

NASA Astrophysics Data System (ADS)

Panaitescu, A.

2017-03-01

We present the light curves and spectra of 24 afterglows that have been monitored by Fermi-LAT at 0.1-100 GeV over more than a decade. All light curves (except 130427) are consistent with a single power law starting from their peaks, which occur in most cases before the burst end. The light curves display a brightness-decay rate correlation, with all but one (130427) of the bright afterglows decaying faster than the dimmer afterglows. We attribute this dichotomy to the quick deposition of relativistic ejecta energy in the external shock for the brighter/faster-decaying afterglows and to an extended energy injection in the afterglow shock for the dimmer/slower-decaying light curves. The spectra of six afterglows (090328, 100414, 110721, 110731, 130427, 140619B) indicate the existence of a harder component above a spectral dip or ankle at energies of 0.3-3 GeV, offering evidence for inverse-Compton emission at higher energies and suggesting that the harder power-law spectra of five other LAT afterglows (130327B, 131231, 150523, 150627, 160509) could also be inverse-Compton, while the remaining, softer LAT afterglows should be synchrotron emission. Marginal evidence for a spectral break and softening at higher energies is found for two afterglows (090902B and 090926).

SPECTRAL ANALYSIS OF FERMI -LAT BLAZARS ABOVE 50 GEV

DOE PAGES

Domínguez, Alberto; Ajello, Marco

2015-11-04

We present an analysis of the intrinsic (unattenuated by the extragalactic background light, EBL) power-law spectral indices of 128 extragalactic sources detected up to z ~ 2 with the Fermi-Large Area Telescope (LAT) at very high energies (VHEs, E ≥50 GeV). The median of the intrinsic index distribution is 2.20 (versus 2.54 for the observed distribution). We also analyze the observed spectral breaks (i.e., the difference between the VHE and high energy, HE, 100 MeV ≤ E ≤ 300 GeV, spectral indices). The Fermi-LAT has now provided a large sample of sources detected both at VHE and HE with comparablemore » exposure that allows us to test models of extragalactic γ-ray photon propagation. We find that our data are compatible with simulations that include intrinsic blazar curvature and EBL attenuation. There is also no evidence of evolution with redshift of the physics that drives the photon emission in high-frequency synchrotron peak (HSP) blazars. This makes HSP blazars excellent probes of the EBL.« less

NASA's Fermi Telescope Resolves Radio Galaxy Centaurus A

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 Fermi's Large Area Telescope resolved high-energy gamma rays from an extended region around the active galaxy Centaurus A. The emission corresponds to million-light-year-wide radio-emitting gas thrown out by the galaxy's supersized black hole. This inset shows an optical/gamma-ray composite of the galaxy and its location on the Fermi one-year sky map. Credit: NASA/DOE/Fermi LAT Collaboration, Capella Observatory To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

FLaapLUC: A pipeline for the generation of prompt alerts on transient Fermi-LAT γ-ray sources

NASA Astrophysics Data System (ADS)

Lenain, J.-P.

2018-01-01

The large majority of high energy sources detected with Fermi-LAT are blazars, which are known to be very variable sources. High cadence long-term monitoring simultaneously at different wavelengths being prohibitive, the study of their transient activities can help shedding light on our understanding of these objects. The early detection of such potentially fast transient events is the key for triggering follow-up observations at other wavelengths. A Python tool, FLaapLUC, built on top of the Science Tools provided by the Fermi Science Support Center and the Fermi-LAT collaboration, has been developed using a simple aperture photometry approach. This tool can effectively detect relative flux variations in a set of predefined sources and alert potential users. Such alerts can then be used to trigger target of opportunity observations with other facilities. It is shown that FLaapLUC is an efficient tool to reveal transient events in Fermi-LAT data, providing quick results which can be used to promptly organise follow-up observations. Results from this simple aperture photometry method are also compared to full likelihood analyses. The FLaapLUC package is made available on GitHub and is open to contributions by the community.

NuLat: 3D Event Reconstruction of a ROL Detector for Neutrino Detection and Background Rejection

NASA Astrophysics Data System (ADS)

Yokley, Zachary; NuLat Collaboration

2015-04-01

NuLat is a proposed very-short baseline reactor antineutrino experiment that employs a unique detector design, a Ragahavan Optical Lattice (ROL), developed for the LENS solar neutrino experiment. The 3D lattice provides high spatial and temporal resolution and allows for energy deposition in each voxel to be determined independently of other voxels, as well as the time sequence associated with each voxel energy deposition. This unique feature arises from two independent means to spatially locate energy deposits: via timing and via optical channeling. NuLat, the first application of a ROL detector targeting physics results, will measure the reactor antineutrino flux at very short baselines via inverse beta decay (IBD). The ROL design of NuLat makes possible the reconstruction of positron energy with little contamination due to the annihilation gammas which smear the positron energy resolution in a traditional detector. IBD events are cleanly tagged via temporal and spatial coincidence of neutron capture in the vertex voxel or nearest neighbors. This talk will present work on IBD event reconstruction in NuLat and its likely impact on sterile neutrino detection via operation in higher background locations enabled by its superior rejection of backgrounds. This research has been funded in part by the National Science Foundation on Award Numbers 1001394 and 1001078.

Interaction of S100A1 with LATS1 promotes cell growth through regulation of the Hippo pathway in hepatocellular carcinoma.

PubMed

Guo, Qingping; Wang, Jiale; Cao, Zeyu; Tang, Yongchang; Feng, Chao; Huang, Feizhou

2018-06-05

Despite advances in surgery and chemotherapy, the prognosis of patients with hepatocellular carcinoma (HCC) remains poor. In the present study, the role of S100A1 in the progression of HCC was investigated. Immunohistochemical staining was used to measure the expression of S100A1 in HCC tissues. S100A1 was knocked down by siRNA. A battery of experiments was used to evaluate the biology functions of S100A1. It was found that S100A1 was upregulated in HCC tissues, and its upregulation was associated with a large tumor size, low differentiation and shorter survival time. The biological experiments demonstrated that S100A1 functions as an oncogene in HCC. It was also found that S100A1 knockdown enhanced the inhibitory effects of cisplatin on HCC cells. The results showed that the downregulation of S100A1 induced the phosphorylation of yes‑associated protein (YAP), and treatment with CHX demonstrated that the downregulation of S100A1 accelerated YAP protein degradation. The downregulation of S100A1 did not alter the expression of mammalian sterile 20‑like kinase (MST)1/2 or phosphorylated MST1/2, but upregulated the phosphorylation of large tumor suppressor kinase 1 (LATS1). It was further confirmed that S100A1 interacted with LATS1. LATS1 depletion significantly reduced the effects of S100A1 on cell growth rate and apoptosis, and there was a positive correlation between phosphorylated LATS1 and S100A1 in clinical samples, indicating that LATS1 was responsible for the S100A1-induced changes in cancer cell growth and Hippo signaling. In conclusion, the results of the present study indicated that S100A1 functions as an oncogene and may be a biomarker for the prognosis of patients with HCC. S100A1 exerted its oncogenic function by interacting with LATS1 and activating YAP. S100A1 may serve as a target for novel therapies in HCC.

A PLC-γ1-independent, RasGRP1-ERK dependent pathway drives lymphoproliferative disease in LAT-Y136F mutant mice

PubMed Central

Kortum, Robert L.; Rouquette-Jazdanian, Alexandre K.; Miyaji, Michihiko; Merrill, Robert K.; Markegard, Evan; Pinski, John M.; Wesselink, Amelia; Nath, Nandan N.; Alexander, Clayton P.; Li, Wenmei; Kedei, Noemi; Roose, Jeroen P.; Blumberg, Peter M.; Samelson, Lawrence E.; Sommers, Connie L.

2012-01-01

Mice expressing a germline mutation in the PLC-γ1 binding site of LAT (linker for activation of T cells) show progressive lymphoproliferation and ultimately die at 4–6 months of age. The hyper-activated T cells in these mice show defective TCR-induced calcium flux, but enhanced Ras/ERK activation that is critical for disease progression. Despite the loss of LAT-dependent PLC-γ1 binding and activation, genetic analysis revealed RasGRP1, and not Sos1 or Sos2, to be the major RasGEF responsible for ERK activation and the lymphoproliferative phenotype in these mice. Analysis of isolated CD4+ T cells from LAT-Y136F mice showed altered proximal TCR-dependent kinase signaling, which activated a Zap70- and LAT-independent pathway. Moreover, LAT-Y136F T cells showed ERK activation that was dependent on Lck and/or Fyn, PKCθ, and RasGRP1. These data demonstrate a novel route to Ras activation in vivo in a pathological setting. PMID:23209318

3FHL: The Third Catalog of Hard Fermi -LAT Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ajello, M.; Atwood, W. B.; Baldini, L.

Here, we present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi-LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (zmore » > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10 -11 ph cm -2 s -1, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ-ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. We also estimate that for the same flux limit of 10 -12 erg cm -2 s -1, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.« less

3FHL: The Third Catalog of Hard Fermi -LAT Sources

DOE PAGES

Ajello, M.; Atwood, W. B.; Baldini, L.; ...

2017-09-27

Here, we present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi-LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (zmore » > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10 -11 ph cm -2 s -1, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ-ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. We also estimate that for the same flux limit of 10 -12 erg cm -2 s -1, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.« less

3FHL: The Third Catalog of Hard Fermi-LAT Sources

NASA Astrophysics Data System (ADS)

Ajello, M.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Bloom, E. D.; Bonino, R.; Bregeon, J.; Britto, R. J.; Bruel, P.; Buehler, R.; Buson, S.; Cameron, R. A.; Caputo, R.; Caragiulo, M.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiaro, G.; Ciprini, S.; Cohen, J. M.; Costantin, D.; Costanza, F.; Cuoco, A.; Cutini, S.; D'Ammando, F.; de Palma, F.; Desiante, R.; Digel, S. W.; Di Lalla, N.; Di Mauro, M.; Di Venere, L.; Domínguez, A.; Drell, P. S.; Dumora, D.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Fortin, P.; Franckowiak, A.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Green, D.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Harding, A. K.; Hays, E.; Hewitt, J. W.; Horan, D.; Jóhannesson, G.; Kensei, S.; Kuss, M.; La Mura, G.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Li, J.; Longo, F.; Loparco, F.; Lott, B.; Lubrano, P.; Magill, J. D.; Maldera, S.; Manfreda, A.; Mazziotta, M. N.; McEnery, J. E.; Meyer, M.; Michelson, P. F.; Mirabal, N.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Negro, M.; Nuss, E.; Ohsugi, T.; Omodei, N.; Orienti, M.; Orlando, E.; Palatiello, M.; Paliya, V. S.; Paneque, D.; Perkins, J. S.; Persic, M.; Pesce-Rollins, M.; Piron, F.; Porter, T. A.; Principe, G.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Reposeur, T.; Saz Parkinson, P. M.; Sgrò, C.; Simone, D.; Siskind, E. J.; Spada, F.; Spandre, G.; Spinelli, P.; Stawarz, L.; Suson, D. J.; Takahashi, M.; Tak, D.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Torres, D. F.; Torresi, E.; Troja, E.; Vianello, G.; Wood, K.; Wood, M.

2017-10-01

We present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi-LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV-2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (z > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10-11 ph cm-2 s-1, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ-ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. Furthermore, we estimate that for the same flux limit of 10-12 erg cm-2 s-1, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.

Fermi-LAT Bright Gamma-ray Detection of Nova ASASSN-18fv

NASA Astrophysics Data System (ADS)

Jean, P.; Cheung, C. C.; Ojha, R.; van Zyl, P.; Angioni, R.

2018-04-01

The Large Area Telescope (LAT), one of two instruments on the Fermi Gamma-ray Space Telescope, has observed bright gamma-ray emission from a source positionally consistent with the bright optical nova ASASSN-18fv (ATel #11454, #11456, #11460, #11467, #11508).

Seven-year Collection of Well-monitored Fermi -LAT Gamma-Ray Burst Afterglows

DOE PAGES

Panaitescu, Alin-Daniel

2017-02-27

Here we present the light curves and spectra of 24 afterglows that have been monitored by Fermi-LAT at 0.1–100 GeV over more than a decade. All light curves (except 130427) are consistent with a single power law starting from their peaks, which occur in most cases before the burst end. The light curves display a brightness–decay rate correlation, with all but one (130427) of the bright afterglows decaying faster than the dimmer afterglows. We attribute this dichotomy to the quick deposition of relativistic ejecta energy in the external shock for the brighter/faster-decaying afterglows and to an extended energy injection inmore » the afterglow shock for the dimmer/slower-decaying light curves. The spectra of six afterglows (090328, 100414, 110721, 110731, 130427, 140619B) indicate the existence of a harder component above a spectral dip or ankle at energies of 0.3–3 GeV, offering evidence for inverse-Compton emission at higher energies and suggesting that the harder power-law spectra of five other LAT afterglows (130327B, 131231, 150523, 150627, 160509) could also be inverse-Compton, while the remaining, softer LAT afterglows should be synchrotron emission. Finally, marginal evidence for a spectral break and softening at higher energies is found for two afterglows (090902B and 090926).« less

Seven-year Collection of Well-monitored Fermi -LAT Gamma-Ray Burst Afterglows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Panaitescu, Alin-Daniel

Here we present the light curves and spectra of 24 afterglows that have been monitored by Fermi-LAT at 0.1–100 GeV over more than a decade. All light curves (except 130427) are consistent with a single power law starting from their peaks, which occur in most cases before the burst end. The light curves display a brightness–decay rate correlation, with all but one (130427) of the bright afterglows decaying faster than the dimmer afterglows. We attribute this dichotomy to the quick deposition of relativistic ejecta energy in the external shock for the brighter/faster-decaying afterglows and to an extended energy injection inmore » the afterglow shock for the dimmer/slower-decaying light curves. The spectra of six afterglows (090328, 100414, 110721, 110731, 130427, 140619B) indicate the existence of a harder component above a spectral dip or ankle at energies of 0.3–3 GeV, offering evidence for inverse-Compton emission at higher energies and suggesting that the harder power-law spectra of five other LAT afterglows (130327B, 131231, 150523, 150627, 160509) could also be inverse-Compton, while the remaining, softer LAT afterglows should be synchrotron emission. Finally, marginal evidence for a spectral break and softening at higher energies is found for two afterglows (090902B and 090926).« less

Fermi LAT Results and Perspectives in Measurements of High Energy Galactic Cosmic Rays

NASA Technical Reports Server (NTRS)

Moiseev, Alexander

2010-01-01

Real breakthrough during last 1-1.5 years in cosmic ray electrons: ATIC, HESS, Pamela, and finally Fermi-LAT. New quality data have made it possible to start quantitative modeling. With the new data more puzzles than before on CR electrons origin. Need "multi-messenger" campaign: electrons, positrons, gammas, X-ray, radio, neutrino... It is viable that we are dealing with at least two distinct mechanisms of "primary" electron (both signs) production: a softer spectrum of negative electrons, and a harder spectrum of both e(+)+e(-). Exotic (e.g. DM) origin is not ruled out. Upper limits on CR electrons anisotropy are set. Good perspectives to have the Fermi LAT results on proton spectrum and positron fraction.

Fermi-LAT kills dark matter interpretations of AMS-02 data. Or not?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Belotsky, Konstantin; Budaev, Ruslan; Kirillov, Alexander

2017-01-01

A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as we show, any rational DM model explaining the positron anomaly abundantly produces final state radiation and Inverse Compton gamma rays, which inevitably leads to a contradiction with Fermi-LAT isotropic diffuse gamma-ray background measurements. Furthermore, the Fermi-LAT observation of Milky Way dwarf satellites, supposed to be rich in DM, revealed no significant signal in gamma rays. We propose a generic approachmore » in which the major contribution to cosmic rays comes from the dark matter disc and prove that the tension between the DM origin of the positron anomaly and the cosmic gamma-ray observations can be relieved. We consider both a simple model, in which DM decay/annihilate into charged leptons, and a model-independent minimal case of particle production, and we estimate the optimal thickness of DM disk. Possible mechanisms of formation and its properties are briefly discussed.« less

FERMI/GLAST Integrated Trending and Plotting System Release 5.0

NASA Technical Reports Server (NTRS)

Ritter, Sheila; Brumer, Haim; Reitan, Denise

2012-01-01

An Integrated Trending and Plotting System (ITPS) is a trending, analysis, and plotting system used by space missions to determine performance and status of spacecraft and its instruments. ITPS supports several NASA mission operational control centers providing engineers, ground controllers, and scientists with access to the entire spacecraft telemetry data archive for the life of the mission, and includes a secure Web component for remote access. FERMI/GLAST ITPS Release 5.0 features include the option to display dates (yyyy/ddd) instead of orbit numbers along orbital Long-Term Trend (LTT) plot axis, the ability to save statistics from daily production plots as image files, and removal of redundant edit/create Input Definition File (IDF) screens. Other features are a fix to address invalid packet lengths, a change in naming convention of image files in order to use in script, the ability to save all ITPS plot images (from Windows or the Web) as GIF or PNG format, the ability to specify ymin and ymax on plots where previously only the desired range could be specified, Web interface capability to plot IDFs that contain out-oforder page and plot numbers, and a fix to change all default file names to show yyyydddhhmmss time stamps instead of hhmmssdddyyyy. A Web interface capability sorts files based on modification date (with newest one at top), and the statistics block can be displayed via a Web interface. Via the Web, users can graphically view the volume of telemetry data from each day contained in the ITPS archive in the Web digest. The ITPS could be also used in nonspace fields that need to plot data or trend data, including financial and banking systems, aviation and transportation systems, healthcare and educational systems, sales and marketing, and housing and construction.

3FHL: The Third Catalog of Hard Fermi -LAT Sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ajello, M.; Atwood, W. B.; Baldini, L.

We present a catalog of sources detected above 10 GeV by the Fermi Large Area Telescope (LAT) in the first 7 years of data using the Pass 8 event-level analysis. This is the Third Catalog of Hard Fermi -LAT Sources (3FHL), containing 1556 objects characterized in the 10 GeV–2 TeV energy range. The sensitivity and angular resolution are improved by factors of 3 and 2 relative to the previous LAT catalog at the same energies (1FHL). The vast majority of detected sources (79%) are associated with extragalactic counterparts at other wavelengths, including 16 sources located at very high redshift (more » z > 2). Of the sources, 8% have Galactic counterparts and 13% are unassociated (or associated with a source of unknown nature). The high-latitude sky and the Galactic plane are observed with a flux sensitivity of 4.4 to 9.5 × 10{sup −11} ph cm{sup −2} s{sup −1}, respectively (this is approximately 0.5% and 1% of the Crab Nebula flux above 10 GeV). The catalog includes 214 new γ -ray sources. The substantial increase in the number of photons (more than 4 times relative to 1FHL and 10 times to 2FHL) also allows us to measure significant spectral curvature for 32 sources and find flux variability for 163 of them. Furthermore, we estimate that for the same flux limit of 10{sup −12} erg cm{sup −2} s{sup −1}, the energy range above 10 GeV has twice as many sources as the range above 50 GeV, highlighting the importance, for future Cherenkov telescopes, of lowering the energy threshold as much as possible.« less

LAT Region Factors Mediating Differential Neuronal Tropism of HSV-1 and HSV-2 Do Not Act in Trans

PubMed Central

Bertke, Andrea S.; Apakupakul, Kathleen; Ma, AyeAye; Imai, Yumi; Gussow, Anne M.; Wang, Kening; Cohen, Jeffrey I.; Bloom, David C.; Margolis, Todd P.

2012-01-01

After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection. We previously demonstrated that HSV-1 and HSV-2 preferentially establish latent infection in A5+ and KH10+ sensory neurons, respectively, and that exchanging the latency-associated transcript (LAT) between HSV-1 and HSV-2 also exchanges the neuronal preference. Since many viral genes besides the LAT are functionally interchangeable between HSV-1 and HSV-2, we co-infected HSV-1 and HSV-2, both in vivo and in vitro, to determine if trans-acting viral factors regulate whether HSV infection follows a productive or latent pattern of gene expression in sensory neurons. The pattern of HSV-1 and HSV-2 latent infection in trigeminal neurons was no different following co-infection than with either virus alone, consistent with the hypothesis that a trans-acting viral factor is not responsible for the different patterns of latent infection of HSV-1 and HSV-2 in A5+ and KH10+ neurons. Since exchanging the LAT regions between the viruses also exchanges neuronal preferences, we infected transgenic mice that constitutively express 2.8 kb of the LAT region with the heterologous viral serotype. Endogenous expression of LAT did not alter the pattern of latent infection after inoculation with the heterologous serotype virus, demonstrating that the LAT region does not act in trans to direct preferential establishment of latency of HSV-1 and HSV-2. Using HSV1-RFP and HSV2-GFP in adult trigeminal ganglion neurons in vitro, we determined that HSV-1 and HSV-2 do not exert trans-acting effects during acute infection to regulate neuron specificity. Although some neurons were productively infected with both HSV-1 and HSV-2, no A5+ or KH10+ neurons were productively infected with both viruses. Thus, trans-acting viral factors do not regulate preferential permissiveness of A5+ and KH10+ neurons for productive HSV infection and

LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans.

PubMed

Bertke, Andrea S; Apakupakul, Kathleen; Ma, AyeAye; Imai, Yumi; Gussow, Anne M; Wang, Kening; Cohen, Jeffrey I; Bloom, David C; Margolis, Todd P

2012-01-01

After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection. We previously demonstrated that HSV-1 and HSV-2 preferentially establish latent infection in A5+ and KH10+ sensory neurons, respectively, and that exchanging the latency-associated transcript (LAT) between HSV-1 and HSV-2 also exchanges the neuronal preference. Since many viral genes besides the LAT are functionally interchangeable between HSV-1 and HSV-2, we co-infected HSV-1 and HSV-2, both in vivo and in vitro, to determine if trans-acting viral factors regulate whether HSV infection follows a productive or latent pattern of gene expression in sensory neurons. The pattern of HSV-1 and HSV-2 latent infection in trigeminal neurons was no different following co-infection than with either virus alone, consistent with the hypothesis that a trans-acting viral factor is not responsible for the different patterns of latent infection of HSV-1 and HSV-2 in A5+ and KH10+ neurons. Since exchanging the LAT regions between the viruses also exchanges neuronal preferences, we infected transgenic mice that constitutively express 2.8 kb of the LAT region with the heterologous viral serotype. Endogenous expression of LAT did not alter the pattern of latent infection after inoculation with the heterologous serotype virus, demonstrating that the LAT region does not act in trans to direct preferential establishment of latency of HSV-1 and HSV-2. Using HSV1-RFP and HSV2-GFP in adult trigeminal ganglion neurons in vitro, we determined that HSV-1 and HSV-2 do not exert trans-acting effects during acute infection to regulate neuron specificity. Although some neurons were productively infected with both HSV-1 and HSV-2, no A5+ or KH10+ neurons were productively infected with both viruses. Thus, trans-acting viral factors do not regulate preferential permissiveness of A5+ and KH10+ neurons for productive HSV infection and

The dopamine precursor L-dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT2 in renal cortex.

PubMed

Quiñones, Henry; Collazo, Roberto; Moe, Orson W

2004-07-01

The intrarenal autocrine-paracrine dopamine (DA) system is critical for Na(+) homeostasis. l-Dihydroxyphenylalanine (l-DOPA) uptake from the glomerular filtrate and plasma provides the substrate for DA generation by the renal proximal tubule. The transporter(s) responsible for proximal tubule l-DOPA uptake has not been characterized. Renal cortical poly-A(+) RNA injected into Xenopus laevis oocytes induced l-DOPA uptake in a time- and dose-dependent fashion with biphasic K(m)s in the millimolar and micromolar range and independent of inward Na(+), K(+), or H(+) gradients, suggesting the presence of low- and high-affinity l-DOPA carriers. Complementary RNA from two amino acid transporters yielded l-DOPA uptake significantly above water-injected controls the rBAT/b(0,+)AT dimer (rBAT) and the LAT2/4F2 dimer (LAT2). In contradistinction to renal cortical poly-A(+), l-DOPA kinetics of rBAT and LAT2 showed classic Michaelis-Menton kinetics with K(m)s in the micromolar and millimolar range, respectively. Sequence-specific antisense oligonucleotides to rBAT or LAT2 (AS) caused inhibition of rBAT and LAT2 cRNA-induced l-DOPA transport and cortical poly-A(+)-induced arginine and phenylalanine transport. However, the same ASs only partially blocked poly-A(+)-induced l-DOPA transport. In cultured kidney cells, silencing inhibitory RNA (siRNA) to rBAT significantly inhibited l-DOPA uptake. We conclude that rBAT and LAT2 can mediate apical and basolateral l-DOPA uptake into the proximal tubule, respectively. Additional l-DOPA transport mechanisms exist in the renal cortex that remain to be identified.

Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.

PubMed

Zhang, Jing; Liu, Hui; Hou, Lidan; Wang, Ge; Zhang, Rui; Huang, Yanxia; Chen, Xiaoyu; Zhu, Jinshui

2017-09-11

Non-coding RNAs (ncRNAs) have been shown to regulate gene expression involved in tumor progression of multiple malignancies. Our previous studies indicated that large tumor suppressor kinase 1 (LATS1), a core part of Hippo signaling pathway, functions as a tumor suppressor in gastric cancer (GC). But, the underlying molecular mechanisms by which ncRNAs modulate LATS1 expression in GC remain undetermined. The correlation of LATS1 and has-miR-424-5p (miR-424) expression with clinicopathological characteristics and prognosis of GC patients was analyzed by TCGA RNA-sequencing data. A novel circular RNA_LARP4 (circLARP4) was identified to sponge miR-424 by circRNA expression profile and bioinformatic analysis. The binding site between miR-424 and LATS1 or circLARP4 was verified using dual luciferase assay and RNA immunoprecipitation (RIP) assay. The expression and localization of circLARP4 in GC tissues were investigated by fluorescence in situ hybridization (FISH). MTT, colony formation, Transwell and EdU assays were performed to assess the effects of miR-424 or circLARP4 on cell proliferation and invasion. Increased miR-424 expression or decreased LATS1 expression was associated with pathological stage and unfavorable prognosis of GC patients. Ectopic expression of miR-424 promoted proliferation and invasion of GC cells by targeting LATS1 gene. Furthermore, circLARP4 was mainly localized in the cytoplasm and inhibited biological behaviors of GC cells by sponging miR-424. The expression of circLARP4 was downregulated in GC tissues and represented an independent prognostic factor for overall survival of GC patients. circLARP4 may act as a novel tumor suppressive factor and a potential biomarker in GC.

The Third Fermi LAT Catalog of High-Energy Gamma-ray Sources

NASA Astrophysics Data System (ADS)

Thompson, David J.; Ballet, J.; Burnett, T.; Fermi Large Area Telescope Collaboration

2014-01-01

The Fermi Gamma-ray Space Telescope Large Area Telescope (LAT) has been gathering science data since August 2008, surveying the full sky every three hours. The second source catalog (2FGL, Nolan et al 2012, ApJS 199, 31) was based on 2 years of data. We are preparing a third source catalog (3FGL) based on 4 years of reprocessed data. The reprocessing introduced a more accurate description of the instrument, which resulted in a narrower point spread function. Both the localization and the detection threshold for hard-spectrum sources have been improved. The new catalog also relies on a refined model of Galactic diffuse emission, particularly important for low-latitude soft-spectrum sources. The process for associating LAT sources with those at other wavelengths has also improved, thanks to dedicated multiwavelength follow-up, new surveys and better ways to extract sources likely to be gamma-ray counterparts. We describe the construction of this new catalog, its characteristics, and its remaining limitations.

The Third Fermi-LAT Catalog of High-Energy Gamma-ray Sources

NASA Astrophysics Data System (ADS)

Burnett, Toby

2014-03-01

The Fermi Gamma-ray Space Telescope Large Area Telescope (LAT) has been gathering science data since August 2008, surveying the full sky every three hours. The second source catalog (2FGL, Nolan et al. 2012, ApJS 199, 31) was based on 2 years of data. We are preparing a third source catalog (3FGL) based on 4 years of reprocessed data. The reprocessing introduced a more accurate description of the instrument, which resulted in a narrower point spread function. Both the localization and the detection threshold for hard-spectrum sources have been improved. The new catalog also relies on a refined model of Galactic diffuse emission, particularly important for low-latitude soft-spectrum sources. The process for associating LAT sources with those at other wavelengths has also improved, thanks to dedicated multiwavelength follow-up, new surveys and better ways to extract sources likely to be gamma-ray counterparts. We describe the construction of this new catalog, its characteristics, and its remaining limitations.

VizieR Online Data Catalog: Fermi-LAT flaring gamma-ray sources from FAVA (Ackermann+, 2013)

NASA Astrophysics Data System (ADS)

Ackermann, M.; Ajello, M.; Albert, A.; Allafort, A.; Antolini, E.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Bottacini, E.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Cutini, S.; Dalton, M.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; di Venere, L.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Franckowiak, A.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Germani, S.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hewitt, J.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Inoue, Y.; Jackson, M. S.; Jogler, T.; Johannesson, G.; Johnson, W. N.; Kamae, T.; Kataoka, J.; Kawano, T.; Knodlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Lemoine-Goumard, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Mayer, M.; Mazziotta, M. N.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nemmen, R.; Nuss, E.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paneque, D.; Panetta, J. H.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Raino, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Romoli, C.; Roth, M.; Sanchez-Conde, M.; Scargle, J. D.; Schulz, A.; Sgro, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Suson, D. J.; Takahashi, H.; Takeuchi, Y.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Tronconi, V.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Winer, B. L.; Wood, K. S.; Wood, M.; Yang, Z.

2015-01-01

We applied FAVA (Fermi All-sky Variability Analysis) to the first 47 months of Fermi/LAT observations (2008 August 4 to 2012 July 16 UTC), in weekly time intervals. The total number of weeks is 206. We considered two ranges of gamma-ray energy, E>100MeV and E>800MeV, to increase the sensitivity for spectrally soft and hard flares, respectively. We generate measured and expected count maps with a resolution of 0.25deg2 per pixel. We found LAT counterparts for 192 of the 215 FAVA sources. Most of the associated sources, 177, are AGNs. (2 data files).

Role of two adaptor molecules SLP-76 and LAT in the PI3K signaling pathway in activated T cells.

PubMed

Shim, Eun Kyung; Jung, Seung Hee; Lee, Jong Ran

2011-03-01

Previously, we identified p85, a subunit of PI3K, as one of the molecules that interacts with the N-terminal region of Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76). We also demonstrated that tyrosine phosphorylation either at the 113 and/or 128 position is sufficient for the association of SLP-76 with the Src homology 2 domain near the N terminus of p85. The present study further examines the role of the association of these two molecules on the activation of PI3K signaling cascade. Experiments were done to determine the role of SLP-76, either wild-type, tyrosine mutants, or membrane-targeted forms of various SLP-76 constructs, on the membrane localization and phosphorylation of Akt, which is an event downstream of PI3K activation. Reconstitution studies with these various SLP-76 constructs in a Jurkat variant cell line that lacks SLP-76 or linker for activation of T cells (LAT) show that the activation of PI3K pathway following TCR ligation requires both SLP-76 and LAT adaptor proteins. The results suggest that SLP-76 associates with p85 after T cell activation and that LAT recruits this complex to the membrane, leading to Akt activation.

Searches for correlation between UHECR events and high-energy gamma-ray Fermi-LAT data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Álvarez, Ezequiel; Cuoco, Alessandro; Mirabal, Nestor

The astrophysical sources responsible for ultra high-energy cosmic rays (UHECRs) continue to be one of the most intriguing mysteries in astrophysics. We present a comprehensive search for correlations between high-energy (∼> 1 GeV) gamma-ray events from the Fermi Large Area Telescope (LAT) and UHECRs (∼> 60 EeV) detected by the Telescope Array and the Pierre Auger Observatory. We perform two separate searches. First, we conduct a standard cross-correlation analysis between the arrival directions of 148 UHECRs and 360 gamma-ray sources in the Second Catalog of Hard Fermi-LAT sources (2FHL). Second, we search for a possible correlation between UHECR directions andmore » unresolved Fermi -LAT gamma-ray emission. For the latter, we use three different methods: a stacking technique with both a model-dependent and model-independent background estimate, and a cross-correlation function analysis. We also test for statistically significant excesses in gamma rays from signal regions centered on Cen A and the Telescope Array hotspot. No significant correlation is found in any of the analyses performed, except a weak (∼< 2σ) hint of signal with the correlation function method on scales ∼ 1°. Upper limits on the flux of possible power-law gamma-ray sources of UHECRs are derived.« less

VizieR Online Data Catalog: Observation of first Fermi-LAT sources at Parkes (Camilo+, 2015)

NASA Astrophysics Data System (ADS)

Camilo, F.; Kerr, M.; Ray, P. S.; Ransom, S. M.; Sarkissian, J.; Cromartie, H. T.; Johnston, S.; Reynolds, J. E.; Wolff, M. T.; Freire, P. C. C.; Bhattacharyya, B.; Ferrara, E. C.; Keith, M.; Michelson, P. F.; Parkinson, P. M. S.; Wood, K. S.

2017-10-01

Keith et al. (2011MNRAS.414.1292K) used a digital filterbank at Parkes to search 11 unidentified sources from the first Fermi-LAT catalog (1FGL; Abdo et al. 2010, J/ApJS/188/405). Two MSPs and one slow pulsar were discovered in single observations of each target at a central frequency of 1.4 GHz. Subsequently, one of these MSPs was found to be associated with the corresponding LAT source. At nearly the same time, in late 2009, we used an analog filterbank at Parkes to search 14 unidentified 1FGL sources (Kerr et al. 2012ApJ...748L...2K). The single observations of these targets resulted in the detection of six MSPs, five of them discoveries. However, confirmation of some of these MSPs was not easy: the search observations lasted for 1-2 hr each, but some of the pulsars were not detected in equivalent initial confirmation attempts, owing to the effects of interstellar scintillation. These and other selection effects (see Section 2.2 for details) led us to search some promising unidentified LAT sources repeatedly. (1 data file).

The expression of COX-2, hTERT, MDM2, LATS2 and S100A2 in different types of non-small cell lung cancer (NSCLC).

PubMed

Strazisar, Mojca; Mlakar, Vid; Glavac, Damjan

2009-01-01

Several studies have reported different expression levels of certain genes in NSCLC, mostly related to the stage and advancement of the tumours. We investigated 65 stage I-III NSCLC tumours: 32 adenocarcinomas (ADC), 26 squamous cell carcinomas (SCC) and 7 large cell carcinomas (LCC). Using the real-time reverse transcription polymerase chain reaction (RT-PCR), we analysed the expression of the COX-2, hTERT, MDM2, LATS2 and S100A2 genes and researched the relationships between the NSCLC types and the differences in expression levels. The differences in the expression levels of the LATS2, S100A2 and hTERT genes in different types of NSCLC are significant. hTERT and COX-2 were over-expressed and LATS2 under-expressed in all NSCLC. We also detected significant relative differences in the expression of LATS2 and MDM2, hTERT and MDM2 in different types of NSCLC. There was a significant difference in the average expression levels in S100A2 for ADC and SCC. Our study shows differences in the expression patterns within the NSCLC group, which may mimic the expression of the individual NSCLC type, and also new relationships in the expression levels for different NSCLC types.

An image-based search for pulsars among Fermi unassociated LAT sources

NASA Astrophysics Data System (ADS)

Frail, D. A.; Ray, P. S.; Mooley, K. P.; Hancock, P.; Burnett, T. H.; Jagannathan, P.; Ferrara, E. C.; Intema, H. T.; de Gasperin, F.; Demorest, P. B.; Stovall, K.; McKinnon, M. M.

2018-03-01

We describe an image-based method that uses two radio criteria, compactness, and spectral index, to identify promising pulsar candidates among Fermi Large Area Telescope (LAT) unassociated sources. These criteria are applied to those radio sources from the Giant Metrewave Radio Telescope all-sky survey at 150 MHz (TGSS ADR1) found within the error ellipses of unassociated sources from the 3FGL catalogue and a preliminary source list based on 7 yr of LAT data. After follow-up interferometric observations to identify extended or variable sources, a list of 16 compact, steep-spectrum candidates is generated. An ongoing search for pulsations in these candidates, in gamma rays and radio, has found 6 ms pulsars and one normal pulsar. A comparison of this method with existing selection criteria based on gamma-ray spectral and variability properties suggests that the pulsar discovery space using Fermi may be larger than previously thought. Radio imaging is a hitherto underutilized source selection method that can be used, as with other multiwavelength techniques, in the search for Fermi pulsars.

Data acquisition system issues for large experiments

NASA Astrophysics Data System (ADS)

Siskind, E. J.

2007-09-01

This talk consists of personal observations on two classes of data acquisition ("DAQ") systems for Silicon trackers in large experiments with which the author has been concerned over the last three or more years. The first half is a classic "lessons learned" recital based on experience with the high-level debug and configuration of the DAQ system for the GLAST LAT detector. The second half is concerned with a discussion of the promises and pitfalls of using modern (and future) generations of "system-on-a-chip" ("SOC") or "platform" field-programmable gate arrays ("FPGAs") in future large DAQ systems. The DAQ system pipeline for the 864k channels of Si tracker in the GLAST LAT consists of five tiers of hardware buffers which ultimately feed into the main memory of the (two-active-node) level-3 trigger processor farm. The data formats and buffer volumes of these tiers are briefly described, as well as the flow control employed between successive tiers. Lessons learned regarding data formats, buffer volumes, and flow control/data discard policy are discussed. The continued development of platform FPGAs containing large amounts of configurable logic fabric, embedded PowerPC hard processor cores, digital signal processing components, large volumes of on-chip buffer memory, and multi-gigabit serial I/O capability permits DAQ system designers to vastly increase the amount of data preprocessing that can be performed in parallel within the DAQ pipeline for detector systems in large experiments. The capabilities of some currently available FPGA families are reviewed, along with the prospects for next-generation families of announced, but not yet available, platform FPGAs. Some experience with an actual implementation is presented, and reconciliation between advertised and achievable specifications is attempted. The prospects for applying these components to space-borne Si tracker detectors are briefly discussed.

Limits on dark matter annihilation signals from the Fermi LAT 4-year measurement of the isotropic gamma-ray background

DOE PAGES

Ackermann, M.

2015-09-02

We search for evidence of dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) measured with 50 months of Fermi Large Area Telescope (LAT) observations. An improved theoretical description of the cosmological DM annihilation signal, based on two complementary techniques and assuming generic weakly interacting massive particle (WIMP) properties, renders more precise predictions compared to previous work. More specifically, we estimate the cosmologically-induced gamma-ray intensity to have an uncertainty of a factor ~ 20 in canonical setups. We consistently include both the Galactic and extragalactic signals under the same theoretical framework, and study the impact of the former onmore » the IGRB spectrum derivation. We find no evidence for a DM signal and we set limits on the DM-induced isotropic gamma-ray signal. Our limits are competitive for DM particle masses up to tens of TeV and, indeed, are the strongest limits derived from Fermi LAT data at TeV energies. This is possible thanks to the new Fermi LAT IGRB measurement, which now extends up to an energy of 820 GeV. As a result, we quantify uncertainties in detail and show the potential this type of search offers for testing the WIMP paradigm with a complementary and truly cosmological probe of DM particle signals.« less

Limits on dark matter annihilation signals from the Fermi LAT 4-year measurement of the isotropic gamma-ray background

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collaboration: Fermi LAT Collaboration

2015-09-01

We search for evidence of dark matter (DM) annihilation in the isotropic gamma-ray background (IGRB) measured with 50 months of Fermi Large Area Telescope (LAT) observations. An improved theoretical description of the cosmological DM annihilation signal, based on two complementary techniques and assuming generic weakly interacting massive particle (WIMP) properties, renders more precise predictions compared to previous work. More specifically, we estimate the cosmologically-induced gamma-ray intensity to have an uncertainty of a factor ∼ 20 in canonical setups. We consistently include both the Galactic and extragalactic signals under the same theoretical framework, and study the impact of the former on themore » IGRB spectrum derivation. We find no evidence for a DM signal and we set limits on the DM-induced isotropic gamma-ray signal. Our limits are competitive for DM particle masses up to tens of TeV and, indeed, are the strongest limits derived from Fermi LAT data at TeV energies. This is possible thanks to the new Fermi LAT IGRB measurement, which now extends up to an energy of 820 GeV. We quantify uncertainties in detail and show the potential this type of search offers for testing the WIMP paradigm with a complementary and truly cosmological probe of DM particle signals.« less

Fermi-LAT detection of increased gamma-ray activity of TXS 0506+056, located inside the IceCube-170922A error region.

NASA Astrophysics Data System (ADS)

Tanaka, Yasuyuki T.; Buson, Sara; Kocevski, Daniel

2017-09-01

We searched for Fermi-LAT sources inside the extremely high-energy (EHE) IceCube-170922A neutrino event error region (https://gcn.gsfc.nasa.gov/gcn3/21916.gcn3, see also ATels 10773, 10787) with all-sky survey data from the Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope.

Searches for correlation between UHECR events and high-energy gamma-ray Fermi-LAT data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Álvarez, Ezequiel; Cuoco, Alessandro; Mirabal, Nestor

The astrophysical sources responsible for ultra high-energy cosmic rays (UHECRs) continue to be one of the most intriguing mysteries in astrophysics. Here, we present a comprehensive search for correlations between high-energy (≳ 1 GeV) gamma-ray events from the Fermi Large Area Telescope (LAT) and UHECRs (≳ 60 EeV) detected by the Telescope Array and the Pierre Auger Observatory. We perform two separate searches. First, we conduct a standard cross-correlation analysis between the arrival directions of 148 UHECRs and 360 gamma-ray sources in the Second Catalog of Hard Fermi-LAT sources (2FHL). Second, we search for a possible correlation between UHECR directionsmore » and unresolved Fermi-LAT gamma-ray emission. For the latter, we use three different methods: a stacking technique with both a model-dependent and model-independent background estimate, and a cross-correlation function analysis. We also test for statistically significant excesses in gamma rays from signal regions centered on Cen A and the Telescope Array hotspot. There was no significant correlation is found in any of the analyses performed, except a weak (≲ 2σ) hint of signal with the correlation function method on scales ~ 1°. Upper limits on the flux of possible power-law gamma-ray sources of UHECRs are derived.« less

Searches for correlation between UHECR events and high-energy gamma-ray Fermi-LAT data

DOE PAGES

Álvarez, Ezequiel; Cuoco, Alessandro; Mirabal, Nestor; ...

2016-12-13

The astrophysical sources responsible for ultra high-energy cosmic rays (UHECRs) continue to be one of the most intriguing mysteries in astrophysics. Here, we present a comprehensive search for correlations between high-energy (≳ 1 GeV) gamma-ray events from the Fermi Large Area Telescope (LAT) and UHECRs (≳ 60 EeV) detected by the Telescope Array and the Pierre Auger Observatory. We perform two separate searches. First, we conduct a standard cross-correlation analysis between the arrival directions of 148 UHECRs and 360 gamma-ray sources in the Second Catalog of Hard Fermi-LAT sources (2FHL). Second, we search for a possible correlation between UHECR directionsmore » and unresolved Fermi-LAT gamma-ray emission. For the latter, we use three different methods: a stacking technique with both a model-dependent and model-independent background estimate, and a cross-correlation function analysis. We also test for statistically significant excesses in gamma rays from signal regions centered on Cen A and the Telescope Array hotspot. There was no significant correlation is found in any of the analyses performed, except a weak (≲ 2σ) hint of signal with the correlation function method on scales ~ 1°. Upper limits on the flux of possible power-law gamma-ray sources of UHECRs are derived.« less

3FGLzoo: classifying 3FGL unassociated Fermi-LAT γ-ray sources by artificial neural networks

NASA Astrophysics Data System (ADS)

Salvetti, D.; Chiaro, G.; La Mura, G.; Thompson, D. J.

2017-09-01

In its first four years of operation, the Fermi-Large Area Telescope (LAT) detected 3033 γ-ray emitting sources. In the Fermi-LAT Third Source Catalogue (3FGL) about 50 per cent of the sources have no clear association with a likely γ-ray emitter. We use an artificial neural network algorithm aimed at distinguishing BL Lacs from FSRQs to investigate the source subclass of 559 3FGL unassociated sources characterized by γ-ray properties very similar to those of active galactic nuclei. Based on our method, we can classify 271 objects as BL Lac candidates, 185 as FSRQ candidates, leaving only 103 without a clear classification. We suggest a new zoo for γ-ray objects, where the percentage of sources of uncertain type drops from 52 per cent to less than 10 per cent. The result of this study opens up new considerations on the population of the γ-ray sky, and it will facilitate the planning of significant samples for rigorous analyses and multiwavelength observational campaigns.

Constraints on the Galactic Halo Dark Matter From FERMI-LAT Diffuse Measurements

DOE PAGES

Ackermann, M.; Ajello, M.; Atwood, W. B.; ...

2012-11-28

For this study, we have performed an analysis of the diffuse gamma-ray emission with the Fermi Large Area Telescope (LAT) in the Milky Way halo region, searching for a signal from dark matter annihilation or decay. In the absence of a robust dark matter signal, constraints are presented. We consider both gamma rays produced directly in the dark matter annihilation/decay and produced by inverse Compton scattering of the e +/e – produced in the annihilation/decay. Conservative limits are derived requiring that the dark matter signal does not exceed the observed diffuse gamma-ray emission. A second set of more stringent limitsmore » is derived based on modeling the foreground astrophysical diffuse emission using the GALPROP code. Uncertainties in the height of the diffusive cosmic-ray halo, the distribution of the cosmic-ray sources in the Galaxy, the index of the injection cosmic-ray electron spectrum, and the column density of the interstellar gas are taken into account using a profile likelihood formalism, while the parameters governing the cosmic-ray propagation have been derived from fits to local cosmic-ray data. In conclusion, the resulting limits impact the range of particle masses over which dark matter thermal production in the early universe is possible, and challenge the interpretation of the PAMELA/Fermi-LAT cosmic ray anomalies as the annihilation of dark matter.« less

Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Le Vee, Marc; Jouan, Elodie; Lecureur, Valérie

The heterodimeric L-type amino acid transporter (LAT) 1/CD98hc is overexpressed in lung cancers with a poor prognosis factor. Factors that contribute to LAT1/CD98hc overexpression in lung cells remain however to be determined, but the implication of atmospheric pollution can be suspected. The present study was therefore designed to analyze the effects of diesel exhaust particle (DEP) extract (DEPe) on LAT1/CD98hc expression in bronchial epithelial BEAS-2B cells. Exposure to DEPe up-regulated LAT1 and CD98hc mRNA levels in a concentration-dependent manner, with DEPe EC{sub 50} values (around 0.2 μg/mL) relevant to environmental situations. DEPe concomitantly induced LAT1/CD98hc protein expression and LAT1-mediated leucinemore » accumulation in BEAS-2B cells. Inhibition of the aryl hydrocarbon receptor (AhR) pathway through the use of a chemical AhR antagonist or the siRNA-mediated silencing of AhR expression was next found to prevent DEPe-mediated induction of LAT1/CD98hc, indicating that this regulation depends on AhR, known to be activated by major chemical DEP components like polycyclic aromatic hydrocarbons. DEPe exposure was finally shown to induce mRNA expression and activity of matrix metalloproteinase (MMP)-2 in BEAS-2B cells, in a CD98hc/focal adhesion kinase (FAK)/extracellular regulated kinase (ERK) manner, thus suggesting that DEPe-mediated induction of CD98hc triggers activation of the integrin/FAK/ERK signaling pathway known to be involved in MMP-2 regulation. Taken together, these data demonstrate that exposure to DEPe induces functional overexpression of the amino acid transporter LAT1/CD98hc in lung cells. Such a regulation may participate to pulmonary carcinogenic effects of DEPs, owing to the well-documented contribution of LAT1 and CD98hc to cancer development. - Highlights: • The amino acid transporter LAT1/CD98hc is up-regulated in DEPe-treated lung cells. • The aryl hydrocarbon receptor is involved in DEPe-triggered induction of LAT1/CD

Fermi LAT Observations of the Crab Nebula During the Exceptional April 2011 Outburst

NASA Technical Reports Server (NTRS)

Hays, Elizabeth

2012-01-01

The Crab Nebula, formerly thought to be steady in gamma rays, shows unexpected and occasionally dramatic variability in high-energy gamma rays. The Large Area Telescope (LAT) on Fermi recorded several strong outbursts, including dedicated pointed observations of the brightest yet seen, a spectacular flare in April 2011. These observations provide a particularly detailed look at the temporal and spectral characteristics of the nebula during the flare. The LAT data show an additional component in the spectral energy distribution that peaks at a maximum of $375\\pm26\\mathrm{MeV}$. In the probable scenario that this component is synchrotron emission, the electrons are accelerated to extreme energies that are difficult to reconcile with the very rapid change in flux and the expectation for acceleration processes and conditions occurring within the pulsar wind nebula. The physical location and mechanism driving the flares remains undetermined despite observations across the spectrum made by a variety of instruments including the Hubble Space Telescope, the Chandra X-ray Observatory, and the Very Large Array. I will present timing and spectral studies of the high-energy gamma-ray data, discuss implications for the origin of the flares, and highlight preparations for the next major flare.

AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.

PubMed

Philippe, Chloé; Pinson, Benoît; Dompierre, Jim; Pantesco, Véronique; Viollet, Benoît; Daignan-Fornier, Bertrand; Moenner, Michel

2018-06-01

AICAR (Acadesine) is a pharmacological precursor of purine nucleotide biosynthesis with anti-tumoral properties. Although recognized as an AMP mimetic activator of the protein kinase AMPK, the AICAR monophosphate derivative ZMP was also shown to mediate AMPK-independent effects. In order to unveil these AMPK-independent functions, we performed a transcriptomic analysis in AMPKα1/α2 double knockout murine embryonic cells. Kinetic analysis of the cellular response to AICAR revealed the up-regulation of the large tumor suppressor kinases (Lats) 1 and 2 transcripts, followed by the repression of numerous genes downstream of the transcriptional regulators Yap1 and Taz. This transcriptional signature, together with the observation of increased levels in phosphorylation of Lats1 and Yap1 proteins, suggested that the Hippo signaling pathway was activated by AICAR. This effect was observed in both fibroblasts and epithelial cells. Knockdown of Lats1/2 prevented the cytoplasmic delocalization of Yap1/Taz proteins in response to AICAR and conferred a higher resistance to the drug. These results indicate that activation of the most downstream steps of the Hippo cascade participates to the antiproliferative effects of AICAR. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Fermi-LAT observation on magnetars and associated SNRs

NASA Astrophysics Data System (ADS)

Li, Jian; Rea, Nanda; De Ona Wilhelmi, Emma; Torres, Diego F.

2016-07-01

We report on the search for gamma-ray emission from several magnetars using 6 years of Fermi Large Area Telescope (LAT) observations. No significant evidence for gamma-ray emission from any of the currently-known magnetars was found. We derived the most stringent upper limits to date on the 0.1-300 GeV emission from Galactic magnetars, which are estimated between ˜10^{-12} - 10^{-11} erg cm^{-2} s^{-1}. Gamma-ray pulsations were searched for the few sources having reliable ephemerides over the observing period, but none were detected. On the other hand, we studied the gamma-ray morphology and spectra of six SNRs associated with or adjacent to magnetars (namely: CTB109, Kes 73, W41, G337.0-00.1, HB9 and CTB 37A), that have 0.1-300 GeV fluxes between 1.5-14×10^{-11} erg cm^{-2} s^{-1}.

Cen A Radio Optical Gamma Composite

NASA Image and Video Library

2017-12-08

NASA release April 1, 2010 It takes the addition of radio data (orange) to fully appreciate the scale of Cen A's giant radio-emitting lobes, which stretch more than 1.4 million light-years. Gamma-rays from Fermi's Large Area Telescope (purple) and an image of the galaxy in visible light are also included in this composite. Credit: NASA/DOE/Fermi LAT Collaboration, Capella Observatory, and Ilana Feain, Tim Cornwell, and Ron Ekers (CSIRO/ATNF), R. Morganti (ASTRON), and N. Junkes (MPIfR) To learn more about these images go to: www.nasa.gov/mission_pages/GLAST/news/smokestack-plumes.html NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe.

Searching for high-energy gamma-ray counterparts to gravitational-wave sources with Fermi-LAT: A needle in a haystack

DOE PAGES

Vianello, G.; Omodei, N.; Chiang, J.; ...

2017-05-20

At least a fraction of gravitational-wave (GW) progenitors are expected to emit an electromagnetic (EM) signal in the form of a short gamma-ray burst (sGRB). Discovering such a transient EM counterpart is challenging because the LIGO/VIRGO localization region is much larger (several hundreds of square degrees) than the field of view of X-ray, optical, and radio telescopes. The Fermi Large Area Telescope (LAT) has a wide field of view (~2.4 sr) and detects ~2–3 sGRBs per year above 100 MeV. It can detect them not only during the short prompt phase, but also during their long-lasting high-energy afterglow phase. If other wide-field, high-energy instruments such as Fermi-GBM, Swift-BAT, or INTEGRAL-ISGRI cannot detect or localize with enough precision an EM counterpart during the prompt phase, the LAT can potentially pinpoint it withmore » $$\\lesssim 10$$ arcmin accuracy during the afterglow phase. This routinely happens with gamma-ray bursts. Moreover, the LAT will cover the entire localization region within hours of any triggers during normal operations, allowing the γ-ray flux of any EM counterpart to be measured or constrained. As a result, we illustrate two new ad hoc methods to search for EM counterparts with the LAT and their application to the GW candidate LVT151012.« less

Searching for high-energy gamma-ray counterparts to gravitational-wave sources with Fermi-LAT: A needle in a haystack

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vianello, G.; Omodei, N.; Chiang, J.

At least a fraction of gravitational-wave (GW) progenitors are expected to emit an electromagnetic (EM) signal in the form of a short gamma-ray burst (sGRB). Discovering such a transient EM counterpart is challenging because the LIGO/VIRGO localization region is much larger (several hundreds of square degrees) than the field of view of X-ray, optical, and radio telescopes. The Fermi Large Area Telescope (LAT) has a wide field of view (~2.4 sr) and detects ~2–3 sGRBs per year above 100 MeV. It can detect them not only during the short prompt phase, but also during their long-lasting high-energy afterglow phase. If other wide-field, high-energy instruments such as Fermi-GBM, Swift-BAT, or INTEGRAL-ISGRI cannot detect or localize with enough precision an EM counterpart during the prompt phase, the LAT can potentially pinpoint it withmore » $$\\lesssim 10$$ arcmin accuracy during the afterglow phase. This routinely happens with gamma-ray bursts. Moreover, the LAT will cover the entire localization region within hours of any triggers during normal operations, allowing the γ-ray flux of any EM counterpart to be measured or constrained. As a result, we illustrate two new ad hoc methods to search for EM counterparts with the LAT and their application to the GW candidate LVT151012.« less

The First Fermi-LAT Catalog of Sources Above 10 GeV

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Allafort, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Moiseev, Alexander A.

2013-01-01

We present a catalog of gamma-ray sources at energies above 10 GeV based on data from the Large Area Telescope (LAT) accumulated during the first 3 yr of the Fermi Gamma-ray Space Telescope mission. The first Fermi-LAT catalog of >10 GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20 (12) to have significant pulsations in the range >10 GeV (>25 GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27% +/- 8% of the isotropic ? -ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based ? -ray observatories.

Extreme Blazars Studied with Fermi-LAT and Suzaku: 1ES 0347-121 and Blazar Candidate HESS J1943+213

NASA Astrophysics Data System (ADS)

Tanaka, Y. T.; Stawarz, Ł.; Finke, J.; Cheung, C. C.; Dermer, C. D.; Kataoka, J.; Bamba, A.; Dubus, G.; De Naurois, M.; Wagner, S. J.; Fukazawa, Y.; Thompson, D. J.

2014-06-01

We report on our study of high-energy properties of two peculiar TeV emitters: the "extreme blazar" 1ES 0347-121 and the "extreme blazar candidate" HESS J1943+213 located near the Galactic plane. Both objects are characterized by quiescent synchrotron emission with flat spectra extending up to the hard X-ray range, and both were reported to be missing GeV counterparts in the Fermi Large Area Telescope (LAT) two-year Source Catalog. We analyze a 4.5 yr accumulation of the Fermi-LAT data, resulting in the detection of 1ES 0347-121 in the GeV band, as well as in improved upper limits for HESS J1943+213. We also present the analysis results of newly acquired Suzaku data for HESS J1943+213. The X-ray spectrum is well represented by a single power law extending up to 25 keV with photon index 2.00 ± 0.02 and a moderate absorption in excess of the Galactic value, which is in agreement with previous X-ray observations. No short-term X-ray variability was found over the 80 ks duration of the Suzaku exposure. Under the blazar hypothesis, we modeled the spectral energy distributions of 1ES 0347-121 and HESS J1943+213, and we derived constraints on the intergalactic magnetic field strength and source energetics. We conclude that although the classification of HESS J1943+213 has not yet been determined, the blazar hypothesis remains the most plausible option since, in particular, the broadband spectra of the two analyzed sources along with the source model parameters closely resemble each other, and the newly available Wide-field Infrared Survey Explorer and UKIRT Infrared Deep Sky Survey data for HESS J1943+213 are consistent with the presence of an elliptical host at the distance of approximately ~600 Mpc.

Fermi-LAT and Suzaku observations of the radio galaxy Centaurus B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katsuta, J.; Tanaka, Y. T.; Stawarz, Ł.

2013-01-28

Centaurus B is a nearby radio galaxy positioned in the southern hemisphere close to the Galactic plane. Here, in this work, we present a detailed analysis of about 43 months of accumulated Fermi-LAT data of the γ-ray counterpart of the source initially reported in the 2nd Fermi-LAT catalog, and of newly acquired Suzaku X-ray data. We confirm its detection at GeV photon energies and analyze the extension and variability of the γ-ray source in the LAT dataset, in which it appears as a steady γ-ray emitter. The X-ray core of Centaurus B is detected as a bright source of amore » continuum radiation. We do not detect, however, any diffuse X-ray emission from the known radio lobes, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. Two scenarios that connect the X-ray and γ-ray properties are considered. In the first one, we assume that the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. In this case, modeling the inverse-Compton emission shows that the observed γ-ray flux of the source may in principle be produced within the lobes. This association would imply that efficient in-situ acceleration of the radiating electrons is occurring and that the lobes are dominated by the pressure from the relativistic particles. In the second scenario, with the diffuse X-ray emission well below the Suzaku upper limits, the lobes in the system are instead dominated by the magnetic pressure. In this case, the observed γ-ray flux is not likely to be produced within the lobes, but instead within the nuclear parts of the jet. In conclusion, by means of synchrotron self-Compton modeling, we show that this possibility could be consistent with the broad-band data collected for the unresolved core of Centaurus B, including the newly derived Suzaku spectrum.« less

Legal assessment tool (LAT): an interactive tool to address privacy and data protection issues for data sharing.

PubMed

Kuchinke, Wolfgang; Krauth, Christian; Bergmann, René; Karakoyun, Töresin; Woollard, Astrid; Schluender, Irene; Braasch, Benjamin; Eckert, Martin; Ohmann, Christian

2016-07-07

In an unprecedented rate data in the life sciences is generated and stored in many different databases. An ever increasing part of this data is human health data and therefore falls under data protected by legal regulations. As part of the BioMedBridges project, which created infrastructures that connect more than 10 ESFRI research infrastructures (RI), the legal and ethical prerequisites of data sharing were examined employing a novel and pragmatic approach. We employed concepts from computer science to create legal requirement clusters that enable legal interoperability between databases for the areas of data protection, data security, Intellectual Property (IP) and security of biosample data. We analysed and extracted access rules and constraints from all data providers (databases) involved in the building of data bridges covering many of Europe's most important databases. These requirement clusters were applied to five usage scenarios representing the data flow in different data bridges: Image bridge, Phenotype data bridge, Personalised medicine data bridge, Structural data bridge, and Biosample data bridge. A matrix was built to relate the important concepts from data protection regulations (e.g. pseudonymisation, identifyability, access control, consent management) with the results of the requirement clusters. An interactive user interface for querying the matrix for requirements necessary for compliant data sharing was created. To guide researchers without the need for legal expert knowledge through legal requirements, an interactive tool, the Legal Assessment Tool (LAT), was developed. LAT provides researchers interactively with a selection process to characterise the involved types of data and databases and provides suitable requirements and recommendations for concrete data access and sharing situations. The results provided by LAT are based on an analysis of the data access and sharing conditions for different kinds of data of major databases in Europe

Realistic estimation for the detectability of dark matter subhalos using Fermi-LAT catalogs

NASA Astrophysics Data System (ADS)

Calore, Francesca; De Romeri, Valentina; Di Mauro, Mattia; Donato, Fiorenza; Marinacci, Federico

2017-09-01

Numerical simulations of structure formation have made remarkable progress in recent years, in particular due to the inclusion of baryonic physics evolving with the dark matter component. We generate Monte Carlo realizations of the dark matter subhalo population based on the results of the recent hydrodynamical simulation suite of Milky Way-sized galaxies [F. Marinacci, R. Pakmor, and V. Springel, Mon. Not. R. Astron. Soc. 437, 1750 (2014)., 10.1093/mnras/stt2003]. We then simulate the gamma-ray sky for both the setup of the 3FGL and 2FHL Fermi Large Area Telescope (LAT) catalogs, including the contribution from the annihilation of dark matter in the subhalos. We find that the flux sensitivity threshold strongly depends on the particle dark matter mass and, more mildly, also on its annihilation channel and the observation latitude. The results differ for the 3FGL and 2FHL catalogs, given their different energy thresholds. We also predict that the number of dark matter subhalos among the unassociated sources is very small. A null number of detectable subhalos in the Fermi-LAT 3FGL catalog would imply upper limits on the dark matter annihilation cross section into b b ¯ of 2 ×10-26(5 ×10-25) cm3 /s with MDM=50 (1000 ) GeV . We find less than one extended subhalo in the Fermi-LAT 3FGL catalog. As a matter of fact, the differences in the spatial and mass distribution of subhalos between hydrodynamic and dark matter-only runs do not have significant impact on the detectability of dark subhalos in gamma rays.

Fermi/LAT detection of a transient gamma-ray flare in the vicinity of the binary star DG CVn

DOE PAGES

Loh, Alan; Corbel, Stéphane; Dubus, Guillaume

2017-02-16

Solar flares are regularly detected by the Large Area Telescope (LAT) on board the Fermi satellite, however no γ-ray emission from other stellar eruptions has ever been captured. The Swift detection in 2014 April of a powerful outburst originating from DG CVn, with associated optical and radio emissions, enticed us to search for possible 0.1–100 GeV emission from this flaring nearby binary star using the Fermi/LAT. No γ-ray emission is detected from DG CVn in 2014, but we report a significant γ-ray excess in 2012 November, at a position consistent with that of the binary. There are no reports ofmore » contemporary flaring at other wavelengths from DG CVn or any other source within the error circle of the γ-ray source. As a result, we argue that the γ-ray flare is more likely to have been associated with a background blazar than with DG CVn and identify a candidate for follow-up study.« less

Gamma-telescopes Fermi/LAT and GAMMA-400 Trigger Systems Event Recognizing Methods Comparison

NASA Astrophysics Data System (ADS)

Arkhangelskaja, I. V.; Murchenko, A. E.; Chasovikov, E. N.; Arkhangelskiy, A. I.; Kheymits, M. D.

Usually instruments for high-energy γ-quanta registration consists of converter (where γ-quanta produced pairs) and calorimeter for particles energy measurements surrounded by anticoincidence shield used to events identification (whether incident particle was charged or neutral). The influence of pair formation by γ-quanta in shield and the backsplash (moved in the opposite direction particles created due high energy γ-rays interact with calorimeter) should be taken into account. It leads to decrease both effective area and registration efficiency at E>10 GeV. In the presented article the event recognizing methods used in Fermi/LAT trigger system is considered in comparison with the ones applied in counting and triggers signals formation system of gamma-telescope GAMMA-400. The GAMMA-400 (Gamma Astronomical Multifunctional Modular Apparatus) will be the new high-apogee space γ-observatory. The GAMMA-400 consist of converter-tracker based on silicon-strip coordinate detectors interleaved with tungsten foils, imaging calorimeter make of 2 layers of double (x, y) silicon strip coordinate detectors interleaved with planes of CsI(Tl) crystals and the electromagnetic calorimeter CC2 consists only of CsI(Tl) crystals. Several plastics detections systems used as anticoincidence shield, for particles energy and moving direction estimations. The main differences of GAMMA-400 constructions from Fermi/LAT one are using the time-of-flight system with base of 50 cm and double layer structure of plastic detectors provides more effective particles direction definition and backsplash rejection. Also two calorimeters in GAMMA-400 composed the total absorbtion spectrometer with total thickness ∼ 25 X0 or ∼1.2 λ0 for vertical incident particles registration and 54 X0 or 2.5 λ0 for laterally incident ones (where λ0 is nuclear interaction length). It provides energy resolution 1-2% for 10 GeV-3.0×103 GeV events while the Fermi/LAT energy resolution does not reach such a

The first Fermi-LAT catalog of sources above 10 GeV

DOE PAGES

Ackermann, M.; Ajello, M.; Allafort, A.; ...

2013-11-14

Here, we present a catalog of γ-ray sources at energies above 10 GeV based on data from the Large Area Telescope (LAT) accumulated during the first 3 yr of the Fermi Gamma-ray Space Telescope mission. The first Fermi-LAT catalog of >10 GeV sources (1FHL) has 514 sources. For each source we present location, spectrum, a measure of variability, and associations with cataloged sources at other wavelengths. We found that 449 (87%) could be associated with known sources, of which 393 (76% of the 1FHL sources) are active galactic nuclei. Of the 27 sources associated with known pulsars, we find 20more » (12) to have significant pulsations in the range >10 GeV (>25 GeV). In this work we also report that, at energies above 10 GeV, unresolved sources account for 27% ± 8% of the isotropic γ-ray background, while the unresolved Galactic population contributes only at the few percent level to the Galactic diffuse background. We also highlight the subset of the 1FHL sources that are best candidates for detection at energies above 50-100 GeV with current and future ground-based γ-ray observatories.« less

Extreme Blazars Studied With Fermi -Lat And Suzaku : 1es 0347–121 And Blazar Candidate Hess J1943+213

DOE PAGES

Tanaka, Y. T.; Stawarz, Ł.; Finke, J.; ...

2014-05-14

We report on our study of high-energy properties of two peculiar TeV emitters: the “extreme blazar" 1ES 0347-121 and the “extreme blazar candidate" HESS J1943+213 located near the Galactic Plane. Both objects are characterized by quiescent synchrotron emission with flat spectra extending up to the hard X-ray range, and both were reported to be missing GeV counterparts in the Fermi-LAT 2–year Source Catalog. We analyze a 4.5 year accumulation of the Fermi-LAT data, resulting in the detection of 1ES 0347-121 in the GeV band, as well as in improved upper limits for HESS J1943+213. We also present the analysis resultsmore » of newly acquired Suzaku data for HESS J1943+213. The X-ray spectrum is well represented by a single power law extending up to 25 keV with photon index 2.00±0.02 and a moderate absorption in excess of the Galactic value, in agreementwith previous X-ray observations. No short-term X-ray variability was found over the 80 ks duration of the Suzaku exposure. Under the blazar hypothesis, we modeled the spectral energy distributions of 1ES 0347-121 and HESS J1943+213, and derived constraints on the intergalactic magnetic field strength and source energetics. We conclude that although the classification of HESS J1943+213 has not yet been determined, the blazar hypothesis remains the most plausible option, since in particular the broad-band spectra of the two analyzed sources along with the source model parameters closely resemble each other, and the newly available WISE and UKIDSS data for HESS J1943+213 are consistent with the presence of an elliptical host at the distance of approximatel ~ 600Mpc.« less

Chandra X-Ray Observations of the Two Brightest Unidentified High Galactic Latitude Fermi-LAT Gamma-Ray Sources

NASA Technical Reports Server (NTRS)

Cheung, C. C.; Donato, D.; Gehrels, N.; Sokolovsky, K. V.; Giroletti, M.

2012-01-01

We present Chandra ACIS-I X-ray observations of 0FGL J1311.9-3419 and 0FGL J1653.4-0200, the two brightest high Galactic latitude (absolute value (beta) >10 deg) gamma-ray sources from the three-month Fermi Large Area Telescope (LAT) bright source list that are still unidentified. Both were also detected previously by EGRET, and despite dedicated multi-wavelength follow-up, they are still not associated with established classes of gamma-ray emitters like pulsars or radio-loud active galactic nuclei. X-ray sources found in the ACIS-I fields of view are cataloged, and their basic properties are determined. These are discussed as candidate counterparts to 0FGL J1311.9-3419 and 0FGL J1653.4-0200, with particular emphasis on the brightest of the 9 and 13 Chandra sources detected within the respective Fermi-LAT 95% confidence regions. Further follow-up studies, including optical photometric and spectroscopic observations, are necessary to identify these X-ray candidate counterparts in order to ultimately reveal the nature of these enigmatic gamma-ray objects.

Limits to dark matter annihilation cross-section from a combined analysis of MAGIC and Fermi-LAT observations of dwarf satellite galaxies

DOE Office of Scientific and Technical Information (OSTI.GOV)

MAGIC Collaboration

2016-02-01

We present the first joint analysis of gamma-ray data from the MAGIC Cherenkov telescopes and the Fermi Large Area Telescope (LAT) to search for gamma-ray signals from dark matter annihilation in dwarf satellite galaxies. We combine 158 hours of Segue 1 observations with MAGIC with 6-year observations of 15 dwarf satellite galaxies by the Fermi-LAT. We obtain limits on the annihilation cross-section for dark matter particle masses between 10 GeV and 100 TeV—the widest mass range ever explored by a single gamma-ray analysis. These limits improve on previously published Fermi-LAT and MAGIC results by up to a factor of twomore » at certain masses. Our new inclusive analysis approach is completely generic and can be used to perform a global, sensitivity-optimized dark matter search by combining data from present and future gamma-ray and neutrino detectors.« less

Limits to dark matter annihilation cross-section from a combined analysis of MAGIC and Fermi-LAT observations of dwarf satellite galaxies

NASA Astrophysics Data System (ADS)

MAGIC Collaboration; Ahnen, M. L.; Ansoldi, S.; Antonelli, L. A.; Antoranz, P.; Babic, A.; Banerjee, B.; Bangale, P.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Biasuzzi, B.; Biland, A.; Blanch, O.; Bonnefoy, S.; Bonnoli, G.; Borracci, F.; Bretz, T.; Carmona, E.; Carosi, A.; Chatterjee, A.; Clavero, R.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; de Oña Wilhelmi, E.; Delgado Mendez, C.; Di Pierro, F.; Dominis Prester, D.; Dorner, D.; Doro, M.; Einecke, S.; Eisenacher Glawion, D.; Elsaesser, D.; Fernández-Barral, A.; Fidalgo, D.; Fonseca, M. V.; Font, L.; Frantzen, K.; Fruck, C.; Galindo, D.; García López, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Giammaria, P.; Godinović, N.; González Muñoz,; A.; Guberman, D.; Hahn, A.; Hanabata, Y.; Hayashida, M.; Herrera, J.; Hose, J.; Hrupec, D.; Hughes, G.; Idec, W.; Kodani, K.; Konno, Y.; Kubo, H.; Kushida, J.; La Barbera, A.; Lelas, D.; Lindfors, E.; Lombardi, S.; Longo, F.; López-Coto, M. López R.; López-Oramas, A.; Lorenz, E.; Majumdar, P.; Makariev, M.; Mallot, K.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Mazin, D.; Menzel, U.; Miranda, J. M.; Mirzoyan, R.; Moralejo, A.; Moretti, E.; Nakajima, D.; Neustroev, V.; Niedzwiecki, A.; Nievas Rosillo, M.; Nilsson, K.; Nishijima, K.; Noda, K.; Orito, R.; Overkemping, A.; Paiano, S.; Palacio, J.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Paredes-Fortuny, X.; Persic, M.; Poutanen, J.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Rhode, W.; Ribó, M.; Rico, J.; Rodriguez Garcia, J.; Saito, T.; Satalecka, K.; Schultz, C.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Stamerra, A.; Steinbring, T.; Strzys, M.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Thaele, J.; Torres, D. F.; Toyama, T.; Treves, A.; Verguilov, V.; Vovk, I.; Ward, J. E.; Will, M.; Wup, M. H.; Zanins, R.; Aleksić, J.; Wood, M.; Anderson, B.; Bloom, E. D.; Cohen-Tanugi, J.; Drlica-Wagner, A.; Mazziotta, M. N.; Sánchez-Condeai, M.; Strigarian, L.

2016-02-01

We present the first joint analysis of gamma-ray data from the MAGIC Cherenkov telescopes and the Fermi Large Area Telescope (LAT) to search for gamma-ray signals from dark matter annihilation in dwarf satellite galaxies. We combine 158 hours of Segue 1 observations with MAGIC with 6-year observations of 15 dwarf satellite galaxies by the Fermi-LAT. We obtain limits on the annihilation cross-section for dark matter particle masses between 10 GeV and 100 TeV—the widest mass range ever explored by a single gamma-ray analysis. These limits improve on previously published Fermi-LAT and MAGIC results by up to a factor of two at certain masses. Our new inclusive analysis approach is completely generic and can be used to perform a global, sensitivity-optimized dark matter search by combining data from present and future gamma-ray and neutrino detectors.

Revisiting simplified dark matter models in terms of AMS-02 and Fermi-LAT

NASA Astrophysics Data System (ADS)

Li, Tong

2018-01-01

We perform an analysis of the simplified dark matter models in the light of cosmic ray observables by AMS-02 and Fermi-LAT. We assume fermion, scalar or vector dark matter particle with a leptophobic spin-0 mediator that couples only to Standard Model quarks and dark matter via scalar and/or pseudo-scalar bilinear. The propagation and injection parameters of cosmic rays are determined by the observed fluxes of nuclei from AMS-02. We find that the AMS-02 observations are consistent with the dark matter framework within the uncertainties. The AMS-02 antiproton data prefer 30 (50) GeV - 5 TeV dark matter mass and require an effective annihilation cross section in the region of 4 × 10-27 (7 × 10-27) - 4 × 10-24 cm3/s for the simplified fermion (scalar and vector) dark matter models. The cross sections below 2 × 10-26 cm3/s can evade the constraint from Fermi-LAT dwarf galaxies for about 100 GeV dark matter mass.

Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs.

PubMed

Napolitano, Lara; Scalise, Mariafrancesca; Koyioni, Maria; Koutentis, Panayiotis; Catto, Marco; Eberini, Ivano; Parravicini, Chiara; Palazzolo, Luca; Pisani, Leonardo; Galluccio, Michele; Console, Lara; Carotti, Angelo; Indiveri, Cesare

2017-11-01

The LAT1 transporter is acknowledged as a pharmacological target of tumours since it is strongly overexpressed in many human cancers. The purpose of this work was to find novel compounds exhibiting potent and prolonged inhibition of the transporter. To this aim, compounds based on dithiazole and dithiazine scaffold have been screened in the proteoliposome experimental model. Inhibition was tested on the antiport catalysed by hLAT1 as transport of extraliposomal [ 3 H]histidine in exchange with intraliposomal histidine. Out of 59 compounds tested, 8 compounds, showing an inhibition higher than 90% at 100µM concentration, were subjected to dose-response analysis. Two of them exhibited IC 50 lower than 1µM. Inhibition kinetics, performed on the two best inhibitors, indicated a mixed type of inhibition with respect to the substrate. Furthermore, inhibition of the transporter was still present after removal of the compounds from the reaction mixture, but was reversed on addition of dithioerythritol, a S-S reducing agent, indicating the formation of disulfide(s) between the compounds and the protein. Molecular docking of the two best inhibitors on the hLAT1 homology structural model, highlighted interaction with the substrate binding site and formation of a covalent bond with the residue C407. Indeed, the inhibition was impaired in the hLAT1 mutant C407A confirming the involvement of that Cys residue. Treatment of SiHa cells expressing hLAT1 at relatively high level, with the two most potent inhibitors led to cell death which was not observed after treatment with a compound exhibiting very poor inhibitory effect. Copyright © 2017 Elsevier Inc. All rights reserved.

50 CFR Table 3 (north) to Part 660... - 2010 Trip Limits for Open Access Gears North of 40°10′ N. Lat.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2010 Trip Limits for Open Access Gears North of 40°10â² N. Lat. 3 Table 3 (North) to Part 660, Subpart F Wildlife and Fisheries FISHERY... Limits for Open Access Gears North of 40°10′ N. Lat. ER01OC10.020 ER01OC10.021 ...

50 CFR Table 3 (south) to Part 660... - 2010 Trip Limits for Open Access Gears South of 40°10′ N. Lat.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2010 Trip Limits for Open Access Gears South of 40°10â² N. Lat. 3 Table 3 (South) to Part 660, Subpart F Wildlife and Fisheries FISHERY... Limits for Open Access Gears South of 40°10′ N. Lat. ER01OC10.022 ER01OC10.023 ...

Suenos Indocumentados: Using LatCrit to Explore the Testimonios of Undocumented and U.S. Born Chicana College Students on Discourses of Racist Nativism in Education

ERIC Educational Resources Information Center

Huber, Lindsay Perez

2010-01-01

Latina/o critical race theory (LatCrit) is used as an overarching framework that examines the intersectionality of race, class, and gender while also acknowledging the unique forms of subordination within the Latina/o community based on immigration status, language, phenotype, and ethnicity. LatCrit allows for the specific examination of race and…

Localization of the lysine epsilon-aminotransferase (lat) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli.

PubMed Central

Tobin, M B; Kovacevic, S; Madduri, K; Hoskins, J A; Skatrud, P L; Vining, L C; Stuttard, C; Miller, J R

1991-01-01

Lysine epsilon-aminotransferase (LAT) in the beta-lactam-producing actinomycetes is considered to be the first step in the antibiotic biosynthetic pathway. Cloning of restriction fragments from Streptomyces clavuligerus, a beta-lactam producer, into Streptomyces lividans, a nonproducer that lacks LAT activity, led to the production of LAT in the host. DNA sequencing of restriction fragments containing the putative lat gene revealed a single open reading frame encoding a polypeptide with an approximately Mr 49,000. Expression of this coding sequence in Escherichia coli led to the production of LAT activity. Hence, LAT activity in S. clavuligerus is derived from a single polypeptide. A second open reading frame began immediately downstream from lat. Comparison of this partial sequence with the sequences of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D valine (ACV) synthetases from Penicillium chrysogenum and Cephalosporium acremonium and with nonribosomal peptide synthetases (gramicidin S and tyrocidine synthetases) found similarities among the open reading frames. Since mapping of the putative N and C termini of S. clavuligerus pcbAB suggests that the coding region occupies approximately 12 kbp and codes for a polypeptide related in size to the fungal ACV synthetases, the molecular characterization of the beta-lactam biosynthetic cluster between pcbC and cefE (approximately 25 kbp) is nearly complete. Images PMID:1917855

HESS J1640-465 and HESS J1641-463: Two Intriguing TeV Sources in Light of New Fermi-LAT Observations

NASA Astrophysics Data System (ADS)

Lemoine-Goumard, M.; Grondin, M.-H.; Acero, F.; Ballet, J.; Laffon, H.; Reposeur, T.

2014-10-01

We report on γ-ray analysis of the region containing the bright TeV source HESS J1640-465 and the close-by TeV source HESS J1641-463 using 64 months of observations with the Fermi Large Area Telescope (LAT). Previously only one GeV source was reported in this region and was associated with HESS J1640-465. With an increased data set and the improved sensitivity afforded by the reprocessed data (P7REP) of the LAT, we now report the detection, morphological study, and spectral analysis of two distinct sources above 100 MeV. The softest emission in this region comes from the TeV source HESS J1641-463 which is well fitted with a power law of index Γ = 2.47 ± 0.05 ± 0.06 and presents no significant γ-ray signal above 10 GeV, which contrasts with its hard spectrum at TeV energies. The Fermi-LAT spectrum of the second TeV source, HESS J1640-465 is well described by a power-law shape of index Γ = 1.99 ± 0.04 ± 0.07 that links up naturally with the spectral data points obtained by the High Energy Stereoscopic System (H.E.S.S.). These new results provide new constraints concerning the identification of these two puzzling γ-ray sources.

Probing the debris disks of nearby stars with Fermi-LAT

NASA Astrophysics Data System (ADS)

Riley, Alexander; Strigari, Louis; Porter, Troy; Blandford, Roger

2018-01-01

Many nearby stars are known to host circumstellar debris disks, similar to our Sun's asteroid and Kuiper belts, that are believed to be the birthplace of extrasolar planets. The bodies in these objects passively emit gamma radiation resulting from interactions with cosmic rays, as previously observed from measurements of the gamma ray albedo of the Moon. We apply a point source analysis to four nearby debris disks using the past nine years of data taken by Fermi-LAT, and report on the updated prospects for detecting gamma-ray emission from these sources.

Limits to dark matter annihilation cross-section from a combined analysis of MAGIC and Fermi-LAT observations of dwarf satellite galaxies

DOE PAGES

Ahnen, M. L.

2016-02-16

Here, we present the first joint analysis of gamma-ray data from the MAGIC Cherenkov telescopes and the Fermi Large Area Telescope (LAT) to search for gamma-ray signals from dark matter annihilation in dwarf satellite galaxies. We combine 158 hours of Segue 1 observations with MAGIC with 6-year observations of 15 dwarf satellite galaxies by the Fermi-LAT. We obtain limits on the annihilation cross-section for dark matter particle masses between 10 GeV and 100 TeV - the widest mass range ever explored by a single gamma-ray analysis. These limits improve on previously published Fermi-LAT and MAGIC results by up to amore » factor of two at certain masses. Our new inclusive analysis approach is completely generic and can be used to perform a global, sensitivity-optimized dark matter search by combining data from present and future gamma-ray and neutrino detectors.« less

Fermi LAT detection of increased gamma-ray activity from blazar S5 0716+71

NASA Astrophysics Data System (ADS)

Buson, S.

2014-04-01

The Large Area Telescope (LAT), one of two instruments on-board the Fermi Gamma-ray Space Telescope, has observed an increase in gamma-ray activity from a source positionally coincident with the BL Lac object S5 0716+71 (also known as 2FGL J0721.9+7120, Nolan et al. ...

Fermi/LAT observations of lobe-dominant radio galaxy 3C 207 and possible radiation region of γ-rays

NASA Astrophysics Data System (ADS)

Guo, Sheng-Chu; Zhang, Hai-Ming; Zhang, Jin; Liang, En-Wei

2018-06-01

3C 207 is a lobe-dominant radio galaxy with a one sided jet and bright knots, spanning a kpc-Mpc scale, which have been resolved in the radio, optical and X-ray bands. This target was confirmed as a γ-ray emitter with Fermi/LAT, but it is uncertain whether the γ-ray emission region is the core or knots due to the low spatial resolution of Fermi/LAT. We present an analysis of its Fermi/LAT data acquired during the past 9 years. Different from the radio and optical emission from the core, it is found that the γ-ray emission is steady without detection of flux variation at over a 2σ confidence level. This likely implies that the γ-ray emission is from its knots. We collect the radio, optical and X-ray data of knot-A, the closest knot from the core at 1.4″, and compile its spectral energy distribution (SED). Although the single-zone synchrotron+SSC+IC/CMB model that assumes knot-A is at rest can reproduce the SED in the radio-optical-X-ray band, the predicted γ-ray flux is lower than the LAT observations and the derived magnetic field strength deviates from the equipartition condition by 3 orders of magnitude. Assuming that knot-A is moving relativistically, its SED from radio to γ-ray bands would be represented well with the single-zone synchrotron+SSC+IC/CMB model under the equipartition condition. These results likely suggest that the γ-ray emission may be from knot-A via the IC/CMB process and the knot should have relativistical motion. The jet power derived from our model parameters is also roughly consistent with the kinetic power estimated with radio data.

Fermi/LAT Observations of Swift/BAT Seyfert Galaxies: On the Contribution of Radio-Quiet Active Galactic Nuclei to the Extragalactic gamma-Ray Background

NASA Technical Reports Server (NTRS)

Teng, Stacy H.; Mushotzky, Richard F.; Sambruna, Rita M.; Davis, David S.; Reynolds, Christopher S.

2011-01-01

We present the analysis of 2.1 years of Fermi Large Area Telescope (LAT) data on 491 Seyfert galaxies detected by the Swift Burst Alert Telescope (BAT) survey. Only the two nearest objects, NGC 1068 and NGC 4945, which were identified in the Fermi first year catalog, are detected. Using Swift/BAT and radio 20 cm fluxes, we define a new radio-loudness parameter R(sub X,BAT) where radio-loud objects have logR(sub X,BAT) > -4.7. Based on this parameter, only radio-loud sources are detected by Fermi/LAT. An upper limit to the flux of the undetected sources is derived to be approx.2x10(exp -11) photons/sq cm/s, approximately seven times lower than the observed flux of NGC 1068. Assuming a median redshift of 0.031, this implies an upper limit to the gamma-ray (1-100 GeV) luminosity of < approx.3x10(exp 41) erg/s. In addition, we identified 120 new Fermi/LAT sources near the Swift/BAT Seyfert galaxies with significant Fermi/LAT detections. A majority of these objects do not have Swift/BAT counterparts, but their possible optical counterparts include blazars, flat-spectrum radio quasars, and quasars.

FERMI/LAT OBSERVATIONS OF SWIFT/BAT SEYFERT GALAXIES: ON THE CONTRIBUTION OF RADIO-QUIET ACTIVE GALACTIC NUCLEI TO THE EXTRAGALACTIC {gamma}-RAY BACKGROUND

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teng, Stacy H.; Mushotzky, Richard F.; Reynolds, Christopher S.

2011-12-01

We present the analysis of 2.1 years of Fermi Large Area Telescope (LAT) data on 491 Seyfert galaxies detected by the Swift Burst Alert Telescope (BAT) survey. Only the two nearest objects, NGC 1068 and NGC 4945, which were identified in the Fermi first year catalog, are detected. Using Swift/BAT and radio 20 cm fluxes, we define a new radio-loudness parameter R{sub X,BAT} where radio-loud objects have log R{sub X,BAT} > -4.7. Based on this parameter, only radio-loud sources are detected by Fermi/LAT. An upper limit to the flux of the undetected sources is derived to be {approx}2 Multiplication-Sign 10{supmore » -11} photons cm{sup -2} s{sup -1}, approximately seven times lower than the observed flux of NGC 1068. Assuming a median redshift of 0.031, this implies an upper limit to the {gamma}-ray (1-100 GeV) luminosity of {approx}< 3 Multiplication-Sign 10{sup 41} erg s{sup -1}. In addition, we identified 120 new Fermi/LAT sources near the Swift/BAT Seyfert galaxies with significant Fermi/LAT detections. A majority of these objects do not have Swift/BAT counterparts, but their possible optical counterparts include blazars, flat-spectrum radio quasars, and quasars.« less

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS

DOE PAGES

Huang, William Y. C.; Yan, Qingrong; Lin, Wan-Chen; ...

2016-07-01

The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (LAT):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the LAT assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kineticsmore » and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the LAT assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. In conclusion, the generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes.« less

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS

PubMed Central

Huang, William Y. C.; Yan, Qingrong; Lin, Wan-Chen; Chung, Jean K.; Hansen, Scott D.; Christensen, Sune M.; Tu, Hsiung-Lin; Kuriyan, John; Groves, Jay T.

2016-01-01

The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (LAT):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the LAT assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the LAT assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. The generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes. PMID:27370798

Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS.

PubMed

Huang, William Y C; Yan, Qingrong; Lin, Wan-Chen; Chung, Jean K; Hansen, Scott D; Christensen, Sune M; Tu, Hsiung-Lin; Kuriyan, John; Groves, Jay T

2016-07-19

The assembly of cell surface receptors with downstream signaling molecules is a commonly occurring theme in multiple signaling systems. However, little is known about how these assemblies modulate reaction kinetics and the ultimate propagation of signals. Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (LAT):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor signaling system, on supported membranes. Single-molecule dwell time distributions reveal two, well-differentiated kinetic species for both Grb2 and SOS on the LAT assemblies. The majority fraction of membrane-recruited Grb2 and SOS both exhibit fast kinetics and single exponential dwell time distributions, with average dwell times of hundreds of milliseconds. The minor fraction exhibits much slower kinetics, extending the dwell times to tens of seconds. Considering this result in the context of the multistep process by which the Ras GEF (guanine nucleotide exchange factor) activity of SOS is activated indicates that kinetic stabilization from the LAT assembly may be important. This kinetic proofreading effect would additionally serve as a stochastic noise filter by reducing the relative probability of spontaneous SOS activation in the absence of receptor triggering. The generality of receptor-mediated assembly suggests that such effects may play a role in multiple receptor proximal signaling processes.

Fermi LAT detection of increase gamma-ray emission from OJ 248

NASA Astrophysics Data System (ADS)

Orienti, M.; D'Ammando, F.

2012-09-01

The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar OJ 248 (also known as 2FGL J0830.5+2407, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 127.7170254 deg, Dec: 24.1832836 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=0.94 (Hewitt & Burbidge 1993, ApJS, 87, 451).

The Fermi-LAT detection of magnetar-like pulsar PSR J1846-0258 at high-energy gamma-rays

NASA Astrophysics Data System (ADS)

Kuiper, L.; Hermsen, W.; Dekker, A.

2018-03-01

We report the detection of the pulsed signal of the radio-quiet magnetar-like pulsar PSR J1846-0258 in the high-energy γ-ray data of the Fermi Large Area Telescope (Fermi LAT). We produced phase-coherent timing models exploiting RXTE PCA and Swift XRT monitoring data for the post- (magnetar-like) outburst period from 2007 August 28 to 2016 September 4, with independent verification using INTEGRAL ISGRI and Fermi GBM data. Phase-folding barycentric arrival times of selected Fermi LAT events from PSR J1846-0258 resulted in a 4.2σ detection (30-100 MeV) of a broad pulse consistent in shape and aligned in phase with the profiles that we measured with Swift XRT (2.5-10 keV), INTEGRAL ISGRI (20-150 keV), and Fermi GBM (20-300 keV). The pulsed flux (30-100 MeV) is (3.91 ± 0.97) × 10-9 photons cm-2 s-1 MeV-1. Declining significances of the INTEGRAL ISGRI 20-150 keV pulse profiles suggest fading of the pulsed hard X-ray emission during the post-outburst epochs. We revisited with greatly improved statistics the timing and spectral characteristics of PSR B1509-58 as measured with the Fermi LAT. The broad-band pulsed emission spectra (from 2 keV up to GeV energies) of PSR J1846-0258 and PSR B1509-58 can be accurately described with similarly curved shapes, with maximum luminosities at 3.5 ± 1.1 MeV (PSR J1846-0258) and 2.23 ± 0.11 MeV (PSR B1509-58). We discuss possible explanations for observational differences between Fermi LAT detected pulsars that reach maximum luminosities at GeV energies, like the second magnetar-like pulsar PSR J1119-6127, and pulsars with maximum luminosities at MeV energies, which might be due to geometric differences rather than exotic physics in high-B fields.

What can Fermi LAT observation of the Galactic Centre tell us about its active past?

NASA Astrophysics Data System (ADS)

Zaharijas, Gabrijela; Petrović, Jovana; Serpico, Pasquale

The Fermi-LAT gamma-ray data in the inner Galaxy region show several prominent features possibly related to the past activity of the Milky Way's super massive black hole. At a large, 50 deg scale, the Fermi LAT revealed symmetric hour glass structures with hard energy spectra extending up to 100 GeV (and dubbed `the Fermi bubbles'). More recently and closer to the Galactic centre, at the 10 deg scale, several groups have claimed evidence for excess gamma-ray emission that appears symmetric around the Galactic center and has an energy spectrum peaking at few GeVs. We explore here the possibility that this emission originates in inverse Compton emission from high-energy electrons produced in a short duration, burst-like event injecting 1052 - 1053 erg, roughly 106 yrs ago. Several lines of evidence suggest that a series of `burst like' events happened in the vicinity of our black hole in the past and gamma-ray observations may offer a new view of that scenario.

Local H i emissivity measured with FERMI-LAT and implications for Cosmic-ray spectra

DOE Office of Scientific and Technical Information (OSTI.GOV)

Casandjian, Jean -Marc

Cosmic-ray (CR) electrons and nuclei interact with the Galactic interstellar gas and produce high-energy γ-rays. The γ-ray emission rate per hydrogen atom, called emissivity, provides a unique indirect probe of the CR flux. We present the measurement and the interpretation of the emissivity in the solar neighborhood for γ-ray energy from 50 MeV to 50 GeV. We analyzed a subset of 4 yr of observations from the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope ( Fermi) restricted to absolute latitudesmore » $$10^\\circ \\lt | b| \\lt 70^\\circ $$. From a fit to the LAT data including atomic, molecular, and ionized hydrogen column density templates, as well as a dust optical depth map, we derived the emissivities, the molecular hydrogen–to–CO conversion factor $${X}_{\\mathrm{CO}}=(0.902\\pm 0.007)\\times {10}^{20}$$ cm–2 (K km s–1)–1, and the dust-to-gas ratio $${X}_{\\mathrm{DUST}}=(41.4\\pm 0.3)\\times {10}^{20}$$ cm–2 mag–1. Moreover, we detected for the first time γ-ray emission from ionized hydrogen. We compared the extracted emissivities to those calculated from γ-ray production cross sections and to CR spectra measured in the heliosphere. We observed that the experimental emissivities are reproduced only if the solar modulation is accounted for. This provides a direct detection of solar modulation observed previously through the anticorrelation between CR fluxes and solar activity. Lastly, we fitted a parameterized spectral form to the heliospheric CR observations and to the Fermi-LAT emissivity and obtained compatible local interstellar spectra for proton and helium kinetic energy per nucleon between between 1 and 100 GeV and for electron–positrons between 0.1 and 100 GeV.« less

Local H i emissivity measured with FERMI-LAT and implications for Cosmic-ray spectra

DOE PAGES

Casandjian, Jean -Marc

2015-06-20

Cosmic-ray (CR) electrons and nuclei interact with the Galactic interstellar gas and produce high-energy γ-rays. The γ-ray emission rate per hydrogen atom, called emissivity, provides a unique indirect probe of the CR flux. We present the measurement and the interpretation of the emissivity in the solar neighborhood for γ-ray energy from 50 MeV to 50 GeV. We analyzed a subset of 4 yr of observations from the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope ( Fermi) restricted to absolute latitudesmore » $$10^\\circ \\lt | b| \\lt 70^\\circ $$. From a fit to the LAT data including atomic, molecular, and ionized hydrogen column density templates, as well as a dust optical depth map, we derived the emissivities, the molecular hydrogen–to–CO conversion factor $${X}_{\\mathrm{CO}}=(0.902\\pm 0.007)\\times {10}^{20}$$ cm–2 (K km s–1)–1, and the dust-to-gas ratio $${X}_{\\mathrm{DUST}}=(41.4\\pm 0.3)\\times {10}^{20}$$ cm–2 mag–1. Moreover, we detected for the first time γ-ray emission from ionized hydrogen. We compared the extracted emissivities to those calculated from γ-ray production cross sections and to CR spectra measured in the heliosphere. We observed that the experimental emissivities are reproduced only if the solar modulation is accounted for. This provides a direct detection of solar modulation observed previously through the anticorrelation between CR fluxes and solar activity. Lastly, we fitted a parameterized spectral form to the heliospheric CR observations and to the Fermi-LAT emissivity and obtained compatible local interstellar spectra for proton and helium kinetic energy per nucleon between between 1 and 100 GeV and for electron–positrons between 0.1 and 100 GeV.« less

Testing no-scale supergravity with the Fermi Space Telescope LAT

NASA Astrophysics Data System (ADS)

Li, Tianjun; Maxin, James A.; Nanopoulos, Dimitri V.; Walker, Joel W.

2014-05-01

We describe a methodology for testing no-scale supergravity by the LAT instrument onboard the Fermi Space Telescope via observation of gamma ray emissions from lightest supersymmetric (SUSY) neutralino annihilations. For our test vehicle we engage the framework of the SUSY grand unified model no-scale flipped SU(5) with extra vector-like flippon multiplets derived from F-theory, known as { F}-SU(5). We show that through compression of the light stau and light bino neutralino mass difference, where internal bremsstrahlung photons give a dominant contribution, the photon yield from annihilation of SUSY dark matter can be elevated to a number of events potentially observable by the Fermi-LAT in the coming years. Likewise, the increased yield in no-scale { F}-SU(5) may also have rendered the existing observation of a 133 GeV monochromatic gamma ray line visible, if additional data should exclude systematic or statistical explanations. The question of intensity aside, no-scale { F}-SU(5) can indeed provide a natural weakly interacting massive particle candidate with a mass in the correct range to yield γγ and γZ emission lines at mχ ˜ 133 GeV and mχ ˜ 145 GeV, respectively. Additionally, we elucidate the emerging empirical connection between recent Planck satellite data and no-scale supergravity cosmological models which mimic the Starobinsky model of inflation. Together, these experiments furnish rich alternate avenues for testing no-scale { F}-SU(5), and similarly structured models, the results of which may lend independent credence to observations made at the Large Hadron Collider.

VizieR Online Data Catalog: Fermi LAT second source catalog (2FGL) (Nolan+, 2012)

NASA Astrophysics Data System (ADS)

Nolan, P. L.; Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Antolini, E.; Atwood, W. B.; Axelsson, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Belfiore, A.; Bellazzini, R.; Berenji, B.; Bignami, G. F.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Bonnell, J.; Borgland, A. W.; Bottacini, E.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Burnett, T. H.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Campana, R.; Canadas, B.; Cannon, A.; Caraveo, P. A.; Casandjian, J. M.; Cavazzuti, E.; Ceccanti, M.; Cecchi, C.; Celik, O.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Chipaux, R.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Corbet, R.; Cutini, S.; D'Ammando, F.; Davis, D. S.; de Angelis, A.; Decesar, M. E.; Deklotz, M.; de Luca A.; den Hartog, P. R.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Do Couto, E. Silva E.; Drell, P. S.; Drlica-Wagner, A.; Dubois, R.; Dumora, D.; Enoto, T.; Escande, L.; Fabiani, D.; Falletti, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Fortin, P.; Frailis, M.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giebels, B.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guillemot, L.; Guiriec, S.; Gustafsson, M.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Hill, A. B.; Horan, D.; Hou, X.; Hughes, R. E.; Iafrate, G.; Itoh, R.; Johannesson, G.; Johnson, R. P.; Johnson, T. E.; Johnson, A. S.; Johnson, T. J.; Kamae, T.; Katagiri, H.; Kataoka, J.; Katsuta, J.; Kawai, N.; Kerr, M.; Knodlseder, J.; Kocevski, D.; Kuss, M.; Lande, J.; Landriu, D.; Latronico, L.; Lemoine-Goumard, M.; Lionetto, A. M.; Llena Garde, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Marelli, M.; Massaro, E.; Mazziotta, M. N.; McConville, W.; McEnery, J. E.; Mehault, J.; Michelson, P. F.; Minuti, M.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Mongelli, M.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Naumann-God, O. M.; Norris, J. P.; Nuss, E.; Nymark, T.; Ohno, M.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Ozaki, M.; Paneque, D.; Panetta, J. H.; Parent, D.; Perkins, J. S.; Pesce-Rollins, M.; Pierbattista, M.; Pinchera, M.; Piron, F.; Pivato, G.; Porter, T. A.; Racusin, J. L.; Raino, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Reposeur, T.; Ritz, S.; Rochester, L. S.; Romani, R. W.; Roth, M.; Rousseau, R.; Ryde, F.; Sadrozinski, H. F.-W.; Salvetti, D.; Sanchez, D. A.; Saz Parkinson, P. M.; Sbarra, C.; Scargle, J. D.; Schalk, T. L.; Sgro, C.; Shaw, M. S.; Shrader, C.; Siskind, E. J.; Smith, D. A.; Spandre, G.; Spinelli, P.; Stephens, T. E.; Strickman, M. S.; Suson, D. J.; Tajima, H.; Takahashi, H.; Takahashi, T.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tibolla, O.; Tinebra, F.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Vandenbroucke, J.; van Etten, A.; van Klaveren, B.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Wallace, E.; Wang, P.; Werner, M.; Winer, B. L.; Wood, D. L.; Wood, K. S.; Wood, M.; Yang, Z.; Zimmer, S.

2012-06-01

This paper presents a catalog of high-energy γ-ray sources detected, in the 100MeV-100GeV energy range, in the first two years of the Fermi Gamma-ray Space Telescope mission by the Large Area Telescope (LAT), during the period 2008 August 4 (15:43 UTC)-2010 August 1 (01:17 UTC). (4 data files).

Bright gamma-ray emission from TCP J04432130+4721280 (V392 Per) detected by Fermi-LAT

NASA Astrophysics Data System (ADS)

Li, Kwan-Lok; Chomiuk, Laura; Strader, Jay

2018-05-01

We report the Fermi-LAT detection of the optical transient TCP J04432130+4721280 (V392 Per), which was discovered by Yuji Nakamura on 2018-04-29.4740 (CBET #4515) and later identified as a Galactic nova by Wagner et al. (ATel #11588).

GeV-gamma-ray emission regions

NASA Image and Video Library

2017-12-08

NASA's Fermi Closes on Source of Cosmic Rays New images from NASA's Fermi Gamma-ray Space Telescope show where supernova remnants emit radiation a billion times more energetic than visible light. The images bring astronomers a step closer to understanding the source of some of the universe's most energetic particles -- cosmic rays. Fermi mapped GeV-gamma-ray emission regions (magenta) in the W44 supernova remnant. The features clearly align with filaments detectable in other wavelengths. This composite merges X-rays (blue) from the Germany-led ROSAT mission, infrared (red) from NASA's Spitzer Space Telescope, and radio (orange) from the Very Large Array near Socorro, N.M. Credit: NASA/DOE/Fermi LAT Collaboration, ROSAT, JPL-Caltech, and NRAO/AUI For more information: www.nasa.gov/mission_pages/GLAST/news/cosmic-rays-source....

Fermi LAT Observations of the Supernova Remnant W28 (G6.4-0.1)

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2010-06-30

Here, we present detailed analysis of two gamma-ray sources, 1FGL J1801.3–2322c and 1FGL J1800.5–2359c, that have been found toward the supernova remnant (SNR) W28 with the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. 1FGL J1801.3–2322c is found to be an extended source within the boundary of SNR W28, and to extensively overlap with the TeV gamma-ray source HESS J1801–233, which is associated with a dense molecular cloud interacting with the SNR. The gamma-ray spectrum measured with the LAT from 0.2 to 100 GeV can be described by a broken power-law function with a break at ~1more » GeV and photon indices of 2.09 ± 0.08 (stat) ± 0.28 (sys) below the break and 2.74 ± 0.06 (stat) ± 0.09 (sys) above the break. Given the clear association between HESS J1801–233 and the shocked molecular cloud and a smoothly connected spectrum in the GeV-TeV band, we consider the origin of the gamma-ray emission in both GeV and TeV ranges to be the interaction between particles accelerated in the SNR and the molecular cloud. The decay of neutral pions produced in interactions between accelerated hadrons and dense molecular gas provides a reasonable explanation for the broadband gamma-ray spectrum. 1FGL J1800.5–2359c, located outside the southern boundary of SNR W28, cannot be resolved. An upper limit on the size of the gamma-ray emission was estimated to be ~16' using events above ~2 GeV under the assumption of a circular shape with uniform surface brightness. It appears to coincide with the TeV source HESS J1800–240B, which is considered to be associated with a dense molecular cloud that contains the ultra compact H II region W28A2 (G5.89–0.39). In conclusion, we found no significant gamma-ray emission in the LAT energy band at the positions of TeV sources HESS J1800–230A and HESS J1800–230C. The LAT data for HESS J1800–230A combined with the TeV data points indicate a spectral break between 10 GeV and 100 GeV.« less

(18)F-FBPA as a tumor specific tracer of L-type amino acid transporter 1 (LAT1): PET evaluation in tumor and inflammation compared to (18)F-FDG and (11)C-methionine.

PubMed

Watabe, Tadashi; Hatazawa, Jun

2015-01-01

(18)F-FDG-PET is used worldwide for oncology patients. However, we sometimes encounter false positive cases of (18)F-FDG PET, such as moderate uptake in the inflammatory lesion, because (18)F-FDG accumulates not only in the cancer cells but also in the inflammatory cells (macrophage, granulation tissue, etc). To overcome this limitation of (18)F-FDG, we started to use (4-borono-2- [(18)F]fluoro-L-phenylalanine) (18)F-FBPA, an artificial amino acid tracer which is focusing attention as a tumor specific PET tracer. Physiological accumulation of (18)F-FBPA is limited in the kidney and urinary tract in humans, which enable preferable evaluation of uptake in the abdominal organs compared to (11)C-methionine ((11)C-MET). The purpose of this study was to evaluate (18)F-FBPA as a tumor specific tracer by in vitro cellular uptake analysis focusing on the selectivity of L-type amino acid transporter 1 (LAT1), which is specifically expressed in tumor cells, and in vivo PET analysis in rat xenograft and inflammation models compared to (18)F-FDG and (11)C-methionine. Uptake inhibition and efflux experiments were performed in HEK293-LAT1 and LAT2 cells using cold BPA, cold (18)F-FBPA, and hot (18)F-FBPA to evaluate LAT affinity and transport capacity. Position emission tomography studies were performed in rat xenograft model of C6 glioma 2 weeks after the implantation (n=9, body weight=197±10.5g) and subcutaneous inflammation model 4 days after the injection of turpentine oil (n=9, body weight=197±14.4g). Uptake on static PET images were compared among (18)F-FBPA at 60-70min post injection, (18)F-FDG at 60-70min, and (11)C-MET at 20-30min in the tumors and the inflammatory lesions by maximum standardized uptake value (SUVmax). Cellular uptake analysis showed no significant difference in inhibitory effect and efflux of LAT1 between cold (18)F-FBPA and cold BPA, suggesting the same affinity and transport capacity via LAT1. Uptake of (18)F-FBPA via LAT1 was superior to LAT2 by

HESS J1640–465 AND HESS J1641–463: TWO INTRIGUING TeV SOURCES IN LIGHT OF NEW FERMI -LAT OBSERVATIONS

DOE PAGES

Lemoine-Goumard, M.; Grondin, M. -H.; Acero, F.; ...

2014-09-30

We report on γ-ray analysis of the region containing the bright TeV source HESS J1640-465 and the closeby TeV source HESS J1641-463 using 64 months of observationswith the Fermi Large Area Telescope (LAT). Previously only one GeV source was reported in this region and was associated with HESS J1640-465. With an increased dataset and the improved sensitivity afforded by the reprocessed data (P7REP) of the LAT, we now report the detection, morphological study and spectral analysis of two distinct sources above 100 MeV. The softest emission in this region comes from the TeV source HESS J1641-463 which is well fittedmore » with a power law of index Γ = 2.47 ± 0.05 ± 0.06 and presents no significant γ-ray signal above 10 GeV, which contrasts with its hard spectrum at TeV energies. The Fermi-LAT spectrum of the second TeV source, HESS J1640-465 is well described by a power-law shape of index Γ = 1.99 ± 0.04 ± 0.07 that links up naturally with the spectral data points obtained by the High Energy Stereoscopic System (H.E.S.S.). These new results provide new constraints concerning the identification of these two puzzling γ-ray sources.« less

Fermi-LAT Observations of Continued Gamma-ray Activity from Nova ASASSN-16ma

NASA Astrophysics Data System (ADS)

Li, Kwan-Lok; Chomiuk, Laura; Strader, Jay; Cheung, C. C.; Jean, P.; Shore, S. N.; Fermi Large Area Telescope Collaboration

2016-11-01

Following the report of a sudden gamma-ray onset detection of nova ASASSN-16ma coincident with the optical peak of 5.5 mag on November 8 (ATel #9736), ASASSN-16ma was observed to slowly decrease in gamma-rays but has remained bright enough to be detectable with Fermi-LAT over the last 9 days (test statistic, TS > 10 per day, except for November 17 with TS=5).

HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in Neurons

PubMed Central

Catez, Frédéric; Picard, Christel; Held, Kathrin; Gross, Sylvain; Rousseau, Antoine; Theil, Diethilde; Sawtell, Nancy; Labetoulle, Marc; Lomonte, Patrick

2012-01-01

Major human pathologies are caused by nuclear replicative viruses establishing life-long latent infection in their host. During latency the genomes of these viruses are intimately interacting with the cell nucleus environment. A hallmark of herpes simplex virus type 1 (HSV-1) latency establishment is the shutdown of lytic genes expression and the concomitant induction of the latency associated (LAT) transcripts. Although the setting up and the maintenance of the latent genetic program is most likely dependent on a subtle interplay between viral and nuclear factors, this remains uninvestigated. Combining the use of in situ fluorescent-based approaches and high-resolution microscopic analysis, we show that HSV-1 genomes adopt specific nuclear patterns in sensory neurons of latently infected mice (28 days post-inoculation, d.p.i.). Latent HSV-1 genomes display two major patterns, called “Single” and “Multiple”, which associate with centromeres, and with promyelocytic leukemia nuclear bodies (PML-NBs) as viral DNA-containing PML-NBs (DCP-NBs). 3D-image reconstruction of DCP-NBs shows that PML forms a shell around viral genomes and associated Daxx and ATRX, two PML partners within PML-NBs. During latency establishment (6 d.p.i.), infected mouse TGs display, at the level of the whole TG and in individual cells, a substantial increase of PML amount consistent with the interferon-mediated antiviral role of PML. “Single” and “Multiple” patterns are reminiscent of low and high-viral genome copy-containing neurons. We show that LAT expression is significantly favored within the “Multiple” pattern, which underlines a heterogeneity of LAT expression dependent on the viral genome copy number, pattern acquisition, and association with nuclear domains. Infection of PML-knockout mice demonstrates that PML/PML-NBs are involved in virus nuclear pattern acquisition, and negatively regulate the expression of the LAT. This study demonstrates that nuclear domains

Constraints on the Galactic Halo Dark Matter from Fermi-LAT Diffuse Measurements

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Atwood, W. B.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bloom, E. D.;

Einstein@home discovery of four young gamma-ray pulsars in Fermi LAT data

DOE PAGES

Pletsch, Holger J.; Guillemot, L.; Allen, B.; ...

2013-11-26

Here, we report the discovery of four gamma-ray pulsars, detected in computing-intensive blind searches of data from the Fermi Large Area Telescope (LAT). The pulsars were found using a novel search approach, combining volunteer distributed computing via Einstein@Home and methods originally developed in gravitational-wave astronomy. The pulsars PSRs J0554+3107, J1422–6138, J1522–5735, and J1932+1916 are young and energetic, with characteristic ages between 35 and 56 kyr and spin-down powers in the range 6 × 10 34—10 36 erg s –1. They are located in the Galactic plane and have rotation rates of less than 10 Hz, among which the 2.1 Hzmore » spin frequency of PSR J0554+3107 is the slowest of any known gamma-ray pulsar. For two of the new pulsars, we find supernova remnants coincident on the sky and discuss the plausibility of such associations. Deep radio follow-up observations found no pulsations, suggesting that all four pulsars are radio-quiet as viewed from Earth. These discoveries, the first gamma-ray pulsars found by volunteer computing, motivate continued blind pulsar searches of the many other unidentified LAT gamma-ray sources.« less

Radio Detection of the Fermi-LAT Blind Search Millisecond Pulsar J1311-3430

NASA Astrophysics Data System (ADS)

Ray, P. S.; Ransom, S. M.; Cheung, C. C.; Giroletti, M.; Cognard, I.; Camilo, F.; Bhattacharyya, B.; Roy, J.; Romani, R. W.; Ferrara, E. C.; Guillemot, L.; Johnston, S.; Keith, M.; Kerr, M.; Kramer, M.; Pletsch, H. J.; Saz Parkinson, P. M.; Wood, K. S.

2013-01-01

We report the detection of radio emission from PSR J1311-3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (LAT) gamma-ray data. We detected radio pulsations at 2 GHz, visible for <10% of ~4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nançay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with the Jansky Very Large Array. These detections demonstrate that PSR J1311-3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm-3 provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of LAT-detected MSPs. We see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.

Radio Detection of the Fermi-LAT Blind Search Millisecond Pulsar J1311-3430

NASA Technical Reports Server (NTRS)

Ray, P. S.; Ransom, S. M.; Cheung, C. C.; Giroletti, M.; Cognard, I.; Camilo, F.; Bhattacharyya, B.; Roy, J.; Romani, R. W.; Ferrara, E. C.;

EINSTEIN@HOME DISCOVERY OF FOUR YOUNG GAMMA-RAY PULSARS IN FERMI LAT DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pletsch, H. J.; Allen, B.; Aulbert, C.

2013-12-10

We report the discovery of four gamma-ray pulsars, detected in computing-intensive blind searches of data from the Fermi Large Area Telescope (LAT). The pulsars were found using a novel search approach, combining volunteer distributed computing via Einstein@Home and methods originally developed in gravitational-wave astronomy. The pulsars PSRs J0554+3107, J1422–6138, J1522–5735, and J1932+1916 are young and energetic, with characteristic ages between 35 and 56 kyr and spin-down powers in the range 6 × 10{sup 34}—10{sup 36} erg s{sup –1}. They are located in the Galactic plane and have rotation rates of less than 10 Hz, among which the 2.1 Hz spin frequency of PSR J0554+3107 ismore » the slowest of any known gamma-ray pulsar. For two of the new pulsars, we find supernova remnants coincident on the sky and discuss the plausibility of such associations. Deep radio follow-up observations found no pulsations, suggesting that all four pulsars are radio-quiet as viewed from Earth. These discoveries, the first gamma-ray pulsars found by volunteer computing, motivate continued blind pulsar searches of the many other unidentified LAT gamma-ray sources.« less

RADIO DETECTION OF THE FERMI-LAT BLIND SEARCH MILLISECOND PULSAR J1311-3430

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ray, P. S.; Wood, K. S.; Ransom, S. M.

2013-01-20

We report the detection of radio emission from PSR J1311-3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (LAT) gamma-ray data. We detected radio pulsations at 2 GHz, visible for <10% of {approx}4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nancay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with the Jansky Very Largemore » Array. These detections demonstrate that PSR J1311-3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm{sup -3} provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of LAT-detected MSPs. We see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.« less

Diffuse Cosmic Rays Shining in the Galactic Center: A Novel Interpretation of H.E.S.S. and Fermi-LAT γ-Ray Data.

PubMed

Gaggero, D; Grasso, D; Marinelli, A; Taoso, M; Urbano, A

2017-07-21

We present a novel interpretation of the γ-ray diffuse emission measured by Fermi-LAT and H.E.S.S. in the Galactic center (GC) region and the Galactic ridge (GR). In the first part we perform a data-driven analysis based on PASS8 Fermi-LAT data: We extend down to a few GeV the spectra measured by H.E.S.S. and infer the primary cosmic-ray (CR) radial distribution between 0.1 and 3 TeV. In the second part we adopt a CR transport model based on a position-dependent diffusion coefficient. Such behavior reproduces the radial dependence of the CR spectral index recently inferred from the Fermi-LAT observations. We find that the bulk of the GR emission can be naturally explained by the interaction of the diffuse steady-state Galactic CR sea with the gas present in the central molecular zone. Although we confirm the presence of a residual radial-dependent emission associated with a central source, the relevance of the large-scale diffuse component prevents to claim a solid evidence of GC pevatrons.

Search for gamma-ray emission from AE Aquarii with seven year of Fermi LAT observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Jian; Torres, Diego F.; Rea, Nanda

2016-11-14

AE Aquarii (AE Aqr) is a cataclysmic binary hosting one of the fastest rotating (more » $${P}_{\\mathrm{spin}}$$ = 33.08 s) white dwarfs (WDs) known. Based on seven years of Fermi Large Area Telescope (LAT) Pass 8 data, we report on a deep search for gamma-ray emission from AE Aqr. When using X-ray observations from ASCA, XMM-Newton, Chandra, Swift, Suzaku, and NuSTAR, spanning 20 years, we substantially extend and improve the spin ephemeris of AE Aqr. Using this ephemeris, we searched for gamma-ray pulsations at the spin period of the WD. We detected no gamma-ray pulsations above 3σ significance. Neither phase-averaged gamma-ray emission nor gamma-ray variability of AE Aqr is detected by Fermi LAT. We also impose the most restrictive upper limit to the gamma-ray flux from AE Aqr to date: $$1.3\\times {10}^{-12}$$ erg cm -2 s -1 in the 100 MeV–300 GeV energy range, providing constraints on models.« less

Search for Large Extra Dimensions Based on Observations of Neutron Stars with the Fermi-LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Berenji, Bijan

Large extra dimensions (LED) have been proposed to account for the apparent weakness of gravitation. These theories also indicate that the postulated massive Kaluza-Klein (KK) gravitons may be produced by nucleon-nucleon bremsstrahlung in the course of core collapse of supernovae. Hannestad and Raffelt have predicted energy spectra of gamma ray emission from the decay of KK gravitons trapped by the gravity of the remnant neutron stars (NS). These and other authors have used EGRET data on NS to obtain stringent limits on LED. Fermi-LAT is observing radio pulsar positions obtained from radio and x-ray catalogs. NS with certain characteristics aremore » unlikely emitter of gamma rays, and emit in radio and perhaps x-rays. This talk will focus on the blind analysis we plan to perform, which has been developed using the 1st 2 months of all sky data and Monte Carlo simulations, to obtain limits on LED based on about 1 year of Fermi-LAT data. Preliminary limits from this analysis using these first 2 months of data will be also be discussed.« less

Fermi-LAT observations of the diffuse γ-ray emission: Implications for cosmic rays and the interstellar medium

DOE PAGES

Ackermann, M.; Ajello, M.; Atwood, W. B.; ...

2012-04-09

The γ-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Our observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-LAT) mission and compare with models of the diffuse γ-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. In ordermore » to assess uncertainties associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X CO factor, the ratio between integrated CO-line intensity and H2 column density, the fluxes and spectra of the γ-ray point sources from the first Fermi-LAT catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as γ-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. Here, we provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a flatter

FERMI-LAT OBSERVATIONS OF THE DIFFUSE {gamma}-RAY EMISSION: IMPLICATIONS FOR COSMIC RAYS AND THE INTERSTELLAR MEDIUM

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Bechtol, K.

The {gamma}-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-LAT) mission and compare with models of the diffuse {gamma}-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. To assess uncertaintiesmore » associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X{sub CO} factor, the ratio between integrated CO-line intensity and H{sub 2} column density, the fluxes and spectra of the {gamma}-ray point sources from the first Fermi-LAT catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as {gamma}-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. We also provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a

Fermi-LAT observations of the diffuse γ-ray emission: Implications for cosmic rays and the interstellar medium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Atwood, W. B.

The γ-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Our observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-LAT) mission and compare with models of the diffuse γ-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. In ordermore » to assess uncertainties associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X CO factor, the ratio between integrated CO-line intensity and H2 column density, the fluxes and spectra of the γ-ray point sources from the first Fermi-LAT catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as γ-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. Here, we provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a flatter

Fermi-LAT Observations of the Diffuse γ-Ray Emission: Implications for Cosmic Rays and the Interstellar Medium

NASA Astrophysics Data System (ADS)

Ackermann, M.; Ajello, M.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Borgland, A. W.; Brandt, T. J.; Bregeon, J.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Chiang, J.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Cutini, S.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Digel, S. W.; Silva, E. do Couto e.; Drell, P. S.; Drlica-Wagner, A.; Falletti, L.; Favuzzi, C.; Fegan, S. J.; Ferrara, E. C.; Focke, W. B.; Fortin, P.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gaggero, D.; Gargano, F.; Germani, S.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grove, J. E.; Guiriec, S.; Gustafsson, M.; Hadasch, D.; Hanabata, Y.; Harding, A. K.; Hayashida, M.; Hays, E.; Horan, D.; Hou, X.; Hughes, R. E.; Jóhannesson, G.; Johnson, A. S.; Johnson, R. P.; Kamae, T.; Katagiri, H.; Kataoka, J.; Knödlseder, J.; Kuss, M.; Lande, J.; Latronico, L.; Lee, S.-H.; Lemoine-Goumard, M.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Mazziotta, M. N.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Naumann-Godo, M.; Norris, J. P.; Nuss, E.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Paneque, D.; Panetta, J. H.; Parent, D.; Pesce-Rollins, M.; Pierbattista, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Razzaque, S.; Reimer, A.; Reimer, O.; Sadrozinski, H. F.-W.; Sgrò, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Strong, A. W.; Suson, D. J.; Takahashi, H.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Wang, P.; Winer, B. L.; Wood, K. S.; Wood, M.; Yang, Z.; Ziegler, M.; Zimmer, S.

2012-05-01

The γ-ray sky >100 MeV is dominated by the diffuse emissions from interactions of cosmic rays with the interstellar gas and radiation fields of the Milky Way. Observations of these diffuse emissions provide a tool to study cosmic-ray origin and propagation, and the interstellar medium. We present measurements from the first 21 months of the Fermi Large Area Telescope (Fermi-LAT) mission and compare with models of the diffuse γ-ray emission generated using the GALPROP code. The models are fitted to cosmic-ray data and incorporate astrophysical input for the distribution of cosmic-ray sources, interstellar gas, and radiation fields. To assess uncertainties associated with the astrophysical input, a grid of models is created by varying within observational limits the distribution of cosmic-ray sources, the size of the cosmic-ray confinement volume (halo), and the distribution of interstellar gas. An all-sky maximum-likelihood fit is used to determine the X CO factor, the ratio between integrated CO-line intensity and H2 column density, the fluxes and spectra of the γ-ray point sources from the first Fermi-LAT catalog, and the intensity and spectrum of the isotropic background including residual cosmic rays that were misclassified as γ-rays, all of which have some dependency on the assumed diffuse emission model. The models are compared on the basis of their maximum-likelihood ratios as well as spectra, longitude, and latitude profiles. We also provide residual maps for the data following subtraction of the diffuse emission models. The models are consistent with the data at high and intermediate latitudes but underpredict the data in the inner Galaxy for energies above a few GeV. Possible explanations for this discrepancy are discussed, including the contribution by undetected point-source populations and spectral variations of cosmic rays throughout the Galaxy. In the outer Galaxy, we find that the data prefer models with a flatter distribution of cosmic

Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice.

PubMed

Lu, Lingling; Mamiya, Takayoshi; Lu, Ping; Toriumi, Kazuya; Mouri, Akihiro; Hiramatsu, Masayuki; Zou, Li-Bo; Nabeshima, Toshitaka

2011-06-20

Altered glutamatergic neurotransmission in the prefrontal cortex (PFC) has been implicated in a myriad of neuropsychiatric disorders. We previously reported that prenatal exposure to PCP produced long-lasting behavioral deficits, accompanied by the abnormal expression and dysfunction of NMDA receptors. In addition, these behavioral changes were attenuated by clozapine treatment. However, whether the prenatal exposure adversely affects pre-synaptic glutamatergic neurotransmission in postpubertal mice remains unknown. In the present study, we investigated the involvement of prefrontal glutamatergic neurotransmission in the impairment of cognitive and emotional behavior after prenatal PCP treatment (5mg/kg/day) from E6 to E18 in mice. The PCP-treated mice showed an impairment of recognition memory in a novel object recognition test and enhancement of immobility in a forced swimming test at 8 weeks of age. Moreover, the prenatal treatment reduced the extracellular glutamate level, but increased the expression of a glial glutamate transporter (GLAST) in the PFC. The microinjection of DL-threo-β-benzyloxyaspartate (DL-TBOA, 10 nmol/site/bilaterally), a potent blocker of glutamate transporters, reversed these behavioral deficits by enhancing the prefrontal glutamatergic neurotransmission. Taken together, prenatal exposure to PCP produced impairments of long-term memory and emotional function which are associated with abnormalities of pre-synaptic glutamate transmission in the PFC of postpubertal mice. These findings suggest the prenatal inhibition of NMDA receptor function to contribute partly to the pathophysiology of neurodevelopment-related disorders, such as schizophrenia. Copyright © 2011 Elsevier B.V. All rights reserved.

The first Fermi LAT supernova remnant catalog

DOE PAGES

Acero, F.

2016-05-16

To uniformly determine the properties of supernova remnants (SNRs) at high energies, we have developed the first systematic survey at energies from 1 to 100 GeV using data from the Fermi Large Area Telescope. Based on the spatial overlap of sources detected at GeV energies with SNRs known from radio surveys, we classify 30 sources as likely GeV SNRs. We also report 14 marginal associations and 245 flux upper limits. A mock catalog in which the positions of known remnants are scrambled in Galactic longitude, allows us to determine an upper limit of 22% on the number of GeV candidatesmore » falsely identified as SNRs. We have also developed a method to estimate spectral and spatial systematic errors arising from the diffuse interstellar emission model, a key component of all Galactic Fermi LAT analyses. By studying remnants uniformly in aggregate, we measure the GeV properties common to these objects and provide a crucial context for the detailed modeling of individual SNRs. Combining our GeV results with multiwavelength (MW) data, including radio, X-ray, and TeV, demonstrates the need for improvements to previously sufficient, simple models describing the GeV and radio emission from these objects. As a result, we model the GeV and MW emission from SNRs in aggregate to constrain their maximal contribution to observed Galactic cosmic rays.« less

A Search for Transitions between States in Redbacks and Black Widows Using Seven Years of Fermi-LAT Observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torres, Diego F.; Ji, Long; Li, Jian

Considering about seven years of Fermi-Large Area Telescope (LAT) data, we present a systematic search for variability that is possibly related to transitions between states in redbacks and black widow systems. In addition, the transitions are characterized by sudden and significant changes in the gamma-ray flux that persist on a timescale that is much larger than the orbital period. This phenomenology was already detected in the case of two redback systems, PSR J1023+0038 and PSR J1227-4853, which we present here. We show the existence of only one transition for each of these systems over the past seven years. We determinemore » their spectra, establishing high-energy cutoffs at a few GeV for the high gamma-ray state of PSR J1023+0038, and for both states of PSR J1227-4853. The surveying capability of the Fermi-LAT allows further study of whether similar phenomenology has occurred in other sources. Although we have not found any evidence of a state transition for most of the studied pulsars, we note two black-widow systems, PSR J2234+0944 and PSR J1446-4701, whose apparent variabilities are reminiscent of the transitions in PSR J1023+0038 and PSR J1227-4853. Finally, for the other systems, we set limits on potential transitions in their measured gamma-ray light curves.« less

A Search for Transitions between States in Redbacks and Black Widows Using Seven Years of Fermi -LAT Observations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Torres, Diego F.; Li, Jian; Rea, Nanda

Considering about seven years of Fermi -Large Area Telescope (LAT) data, we present a systematic search for variability that is possibly related to transitions between states in redbacks and black widow systems. The transitions are characterized by sudden and significant changes in the gamma-ray flux that persist on a timescale that is much larger than the orbital period. This phenomenology was already detected in the case of two redback systems, PSR J1023+0038 and PSR J1227−4853, which we present here. We show the existence of only one transition for each of these systems over the past seven years. We determine theirmore » spectra, establishing high-energy cutoffs at a few GeV for the high gamma-ray state of PSR J1023+0038, and for both states of PSR J1227−4853. The surveying capability of the Fermi -LAT allows further study of whether similar phenomenology has occurred in other sources. Although we have not found any evidence of a state transition for most of the studied pulsars, we note two black-widow systems, PSR J2234+0944 and PSR J1446−4701, whose apparent variabilities are reminiscent of the transitions in PSR J1023+0038 and PSR J1227−4853. For the other systems, we set limits on potential transitions in their measured gamma-ray light curves.« less

A Search for Transitions between States in Redbacks and Black Widows Using Seven Years of Fermi-LAT Observations

DOE PAGES

Torres, Diego F.; Ji, Long; Li, Jian; ...

2017-02-08

Considering about seven years of Fermi-Large Area Telescope (LAT) data, we present a systematic search for variability that is possibly related to transitions between states in redbacks and black widow systems. In addition, the transitions are characterized by sudden and significant changes in the gamma-ray flux that persist on a timescale that is much larger than the orbital period. This phenomenology was already detected in the case of two redback systems, PSR J1023+0038 and PSR J1227-4853, which we present here. We show the existence of only one transition for each of these systems over the past seven years. We determinemore » their spectra, establishing high-energy cutoffs at a few GeV for the high gamma-ray state of PSR J1023+0038, and for both states of PSR J1227-4853. The surveying capability of the Fermi-LAT allows further study of whether similar phenomenology has occurred in other sources. Although we have not found any evidence of a state transition for most of the studied pulsars, we note two black-widow systems, PSR J2234+0944 and PSR J1446-4701, whose apparent variabilities are reminiscent of the transitions in PSR J1023+0038 and PSR J1227-4853. Finally, for the other systems, we set limits on potential transitions in their measured gamma-ray light curves.« less

HESS J1640–465 AND HESS J1641–463: TWO INTRIGUING TeV SOURCES IN LIGHT OF NEW FERMI-LAT OBSERVATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lemoine-Goumard, M.; Grondin, M.-H.; Laffon, H.

2014-10-10

We report on γ-ray analysis of the region containing the bright TeV source HESS J1640–465 and the close-by TeV source HESS J1641–463 using 64 months of observations with the Fermi Large Area Telescope (LAT). Previously only one GeV source was reported in this region and was associated with HESS J1640–465. With an increased data set and the improved sensitivity afforded by the reprocessed data (P7REP) of the LAT, we now report the detection, morphological study, and spectral analysis of two distinct sources above 100 MeV. The softest emission in this region comes from the TeV source HESS J1641–463 which ismore » well fitted with a power law of index Γ = 2.47 ± 0.05 ± 0.06 and presents no significant γ-ray signal above 10 GeV, which contrasts with its hard spectrum at TeV energies. The Fermi-LAT spectrum of the second TeV source, HESS J1640–465 is well described by a power-law shape of index Γ = 1.99 ± 0.04 ± 0.07 that links up naturally with the spectral data points obtained by the High Energy Stereoscopic System (H.E.S.S.). These new results provide new constraints concerning the identification of these two puzzling γ-ray sources.« less

Fermi LAT detection of an increase in gamma-ray activity of the FSRQ S5 1044+71

NASA Astrophysics Data System (ADS)

Ojha, Roopesh; Carpen, Bryce

2017-01-01

The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar S5 1044+71 (also known as 3FGL J1048.4+7144, Acero et al. 2015, ApJS 218, 23) with radio coordinates R.A: 10h48m27.6199s, Dec: +71d43m35.938s (J2000; Johnston et al. 1995, AJ, 110, 880) and redshift z=1.15 (Polatidis et al. 1995, ApJS, 98, 1). Preliminary results indicate that S5 1044+71 showed a marked increase in activity on 2016 December 29, with a daily flux (E > 100 MeV) of (1.1+/-0.2) x10^-6 ph cm^-2 s^-1 (errors are statistical only) which is a factor of about 16 greater than the average flux reported in the third Fermi LAT catalog (3FGL).

Detergent-Induced Stabilization and Improved 3D Map of the Human Heteromeric Amino Acid Transporter 4F2hc-LAT2

PubMed Central

Harder, Daniel; Stauffer, Mirko; Jeckelmann, Jean-Marc; Brühlmann, Béla; Rosell, Albert; Ilgü, Hüseyin; Kovar, Karin; Palacín, Manuel; Fotiadis, Dimitrios

2014-01-01

Human heteromeric amino acid transporters (HATs) are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-LAT2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission electron microscopy. Here we report the important stabilization of purified human 4F2hc-LAT2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-LAT2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level. PMID:25299125

Detergent-induced stabilization and improved 3D map of the human heteromeric amino acid transporter 4F2hc-LAT2.

PubMed

Meury, Marcel; Costa, Meritxell; Harder, Daniel; Stauffer, Mirko; Jeckelmann, Jean-Marc; Brühlmann, Béla; Rosell, Albert; Ilgü, Hüseyin; Kovar, Karin; Palacín, Manuel; Fotiadis, Dimitrios

2014-01-01

Human heteromeric amino acid transporters (HATs) are membrane protein complexes that facilitate the transport of specific amino acids across cell membranes. Loss of function or overexpression of these transporters is implicated in several human diseases such as renal aminoacidurias and cancer. HATs are composed of two subunits, a heavy and a light subunit, that are covalently connected by a disulphide bridge. Light subunits catalyse amino acid transport and consist of twelve transmembrane α-helix domains. Heavy subunits are type II membrane N-glycoproteins with a large extracellular domain and are involved in the trafficking of the complex to the plasma membrane. Structural information on HATs is scarce because of the difficulty in heterologous overexpression. Recently, we had a major breakthrough with the overexpression of a recombinant HAT, 4F2hc-LAT2, in the methylotrophic yeast Pichia pastoris. Microgram amounts of purified protein made possible the reconstruction of the first 3D map of a human HAT by negative-stain transmission electron microscopy. Here we report the important stabilization of purified human 4F2hc-LAT2 using a combination of two detergents, i.e., n-dodecyl-β-D-maltopyranoside and lauryl maltose neopentyl glycol, and cholesteryl hemisuccinate. The superior quality and stability of purified 4F2hc-LAT2 allowed the measurement of substrate binding by scintillation proximity assay. In addition, an improved 3D map of this HAT could be obtained. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution, and thus the elucidation of the working mechanism of this important protein complex at the molecular level.

Gamma-Ray Flaring Activity from the Gravitationally Lensed Blazar PKS 1830-211 Observed by Fermi LAT

NASA Astrophysics Data System (ADS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Allafort, A.; Amin, M. A.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Blandford, R. D.; Bonamente, E.; Borgland, A. W.; Bregeon, J.; Brigida, M.; Buehler, R.; Bulmash, D.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Cheung, C. C.; Chiang, J.; Chiaro, G.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Corbet, R. H. D.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Dermer, C. D.; Drell, P. S.; Drlica-Wagner, A.; Favuzzi, C.; Finke, J.; Focke, W. B.; Fukazawa, Y.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Grenier, I. A.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Hayashida, M.; Hays, E.; Hughes, R. E.; Inoue, Y.; Jackson, M. S.; Jogler, T.; Jóhannesson, G.; Johnson, A. S.; Kamae, T.; Knödlseder, J.; Kuss, M.; Lande, J.; Larsson, S.; Latronico, L.; Longo, F.; Loparco, F.; Lott, B.; Lovellette, M. N.; Lubrano, P.; Madejski, G. M.; Mazziotta, M. N.; Mehault, J.; Michelson, P. F.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nemmen, R.; Nuss, E.; Ohno, M.; Ohsugi, T.; Paneque, D.; Perkins, J. S.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Reyes, L. C.; Ritz, S.; Romoli, C.; Roth, M.; Saz Parkinson, P. M.; Sgrò, C.; Siskind, E. J.; Spandre, G.; Spinelli, P.; Takahashi, H.; Takeuchi, Y.; Tanaka, T.; Thayer, J. G.; Thayer, J. B.; Thompson, D. J.; Tibaldo, L.; Tinivella, M.; Torres, D. F.; Tosti, G.; Troja, E.; Tronconi, V.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vianello, G.; Vitale, V.; Waite, A. P.; Werner, M.; Winer, B. L.; Wood, K. S.

2015-02-01

The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830-211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 1050 erg s-1, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare, with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830-211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.

Gamma-ray flaring activity from the gravitationally lensed blazar PKS 1830-211 observed by Fermi LAT

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2015-01-23

We present that the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope routinely detects the MeV-peaked flat-spectrum radio quasar PKS 1830–211 (z = 2.507). Its apparent isotropic γ-ray luminosity (E > 100 MeV), averaged over ~3 years of observations and peaking on 2010 October 14/15 at 2.9 × 10 50 erg s –1, makes it among the brightest high-redshift Fermi blazars. No published model with a single lens can account for all of the observed characteristics of this complex system. Based on radio observations, one expects time-delayed variability to follow about 25 days after a primary flare,more » with flux about a factor of 1.5 less. Two large γ-ray flares of PKS 1830–211 have been detected by the LAT in the considered period, and no substantial evidence for such a delayed activity was found. This allows us to place a lower limit of about 6 on the γ-ray flux ratio between the two lensed images. Swift XRT observations from a dedicated Target of Opportunity program indicate a hard spectrum with no significant correlation of X-ray flux with the γ-ray variability. The spectral energy distribution can be modeled with inverse Compton scattering of thermal photons from the dusty torus. The implications of the LAT data in terms of variability, the lack of evident delayed flare events, and different radio and γ-ray flux ratios are discussed. Lastly, microlensing effects, absorption, size and location of the emitting regions, the complex mass distribution of the system, an energy-dependent inner structure of the source, and flux suppression by the lens galaxy for one image path may be considered as hypotheses for understanding our results.« less

Radio Detection of the FERMI-LAT Blind Search Millisecond Pulsar J1311–3430

DOE PAGES

Ray, P. S.; Ransom, S. M.; Cheung, C. C.; ...

2013-01-02

In this article, we report the detection of radio emission from PSR J1311–3430, the first millisecond pulsar (MSP) discovered in a blind search of Fermi Large Area Telescope (LAT) gamma-ray data. We detected radio pulsations at 2 GHz, visible for <10% of ~4.5 hr of observations using the Green Bank Telescope (GBT). Observations at 5 GHz with the GBT and at several lower frequencies with Parkes, Nançay, and the Giant Metrewave Radio Telescope resulted in non-detections. We also report the faint detection of a steep spectrum continuum radio source (0.1 mJy at 5 GHz) in interferometric imaging observations with themore » Jansky Very Large Array. These detections demonstrate that PSR J1311–3430 is not radio quiet and provide additional evidence that radio-quiet MSPs are rare. The radio dispersion measure of 37.8 pc cm –3 provides a distance estimate of 1.4 kpc for the system, yielding a gamma-ray efficiency of 30%, typical of LAT-detected MSPs. Lastly, we see apparent excess delay in the radio pulses as the pulsar appears from eclipse and we speculate on possible mechanisms for the non-detections of the pulse at other orbital phases and observing frequencies.« less

Fermi-LAT Discovery of Extended Gamma-Ray Emission in the Direction of Supernova Remnant W51C

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, A.A.; /Naval Research Lab, Wash., D.C. /Federal City Coll.; Ackermann, M.

The discovery of bright gamma-ray emission coincident with supernova remnant (SNR) W51C is reported using the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope. W51C is a middle-aged remnant ({approx}10{sup 4} yr) with intense radio synchrotron emission in its shell and known to be interacting with a molecular cloud. The gamma-ray emission is spatially extended, broadly consistent with the radio and X-ray extent of SNR W51C. The energy spectrum in the 0.2-50 GeV band exhibits steepening toward high energies. The luminosity is greater than 1 x 10{sup 36} erg s{sup -1} given the distance constraint of D >more » 5.5 kpc, which makes this object one of the most luminous gamma-ray sources in our Galaxy. The observed gamma-rays can be explained reasonably by a combination of efficient acceleration of nuclear cosmic rays at supernova shocks and shock-cloud interactions. The decay of neutral p mesons produced in hadronic collisions provides a plausible explanation for the gamma-ray emission. The product of the average gas density and the total energy content of the accelerated protons amounts to {bar n}{sub H} W{sub p} {approx_equal} 5 x 10{sup 51} (D/6 kpc){sup 2} erg cm{sup -3}. Electron density constraints from the radio and X-ray bands render it difficult to explain the LAT signal as due to inverse Compton scattering. The Fermi LAT source coincident with SNR W51C sheds new light on the origin of Galactic cosmic rays.« less

FERMI LAT Discovery of Extended Gamma-Ray Emission in the Direction of Supernova Remnant W51C

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2009-10-27

In this paper, the discovery of bright gamma-ray emission coincident with supernova remnant (SNR) W51C is reported using the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope. W51C is a middle-aged remnant (~10 4 yr) with intense radio synchrotron emission in its shell and known to be interacting with a molecular cloud. The gamma-ray emission is spatially extended, broadly consistent with the radio and X-ray extent of SNR W51C. The energy spectrum in the 0.2-50 GeV band exhibits steepening toward high energies. The luminosity is greater than 1 × 10 36 erg s –1 given the distance constraint of D > 5.5 kpc, which makes this object one of the most luminous gamma-ray sources in our Galaxy. The observed gamma-rays can be explained reasonably by a combination of efficient acceleration of nuclear cosmic rays at supernova shocks and shock-cloud interactions. The decay of neutral π mesons produced in hadronic collisions provides a plausible explanation for the gamma-ray emission. The product of the average gas density and the total energy content of the accelerated protons amounts tomore » $$\\bar{n}_{\\rm H}W_p \\simeq 5\\times 10^{51}\\ (D/6\\ {\\rm kpc})^2\\ \\rm erg\\ cm^{-3}$$. Electron density constraints from the radio and X-ray bands render it difficult to explain the LAT signal as due to inverse Compton scattering. Finally, the Fermi LAT source coincident with SNR W51C sheds new light on the origin of Galactic cosmic rays.« less

Fermi LAT detection of increased gamma-ray activity from the blazar TXS 1318+225

NASA Astrophysics Data System (ADS)

Torresi, E.; D'Ammando, F.; Tanaka, Y.

2012-11-01

The Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope, has observed an increase in the gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar TXS 1318+225 (z=0.943, Sowards-Emmerd et al. 2003, ApJ, 590, 109; RA=200.2966771 deg, Dec=22.2700300 deg, J2000), also known as 2FGL J1321.1+2215 (Nolan et al. 2012, ApJS, 199, 31).

50 CFR Table 1c to Part 660... - Sablefish North of 36° N. lat. Allocations, 2013

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Sablefish North of 36° N. lat. Allocations, 2013 1c Table 1c to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF...

Effective doses and organ doses in the MIRD-5 phantom exposed to monoenergetic 0.1 MeV to 200 MeV electrons in the LAT direction.

PubMed

Katagiri, M; Hikoji, M; Kitaichi, M; Aoki, Y; Sawamura, S

2001-01-01

Organ doses and effective doses were calculated using the EGS-4 Monte Carlo simulation code and a MIRD-5 mathematical human phantom placed in a vacuum. For broad right and left lateral beams of monoenergetic (0.1-200 MeV) electrons, conversion coefficients from the incident fluence to organ dose, to effective dose, and to effective dose equivalent were obtained. There were no clear differences between the conversion coefficients in the case of left-lateral (LLAT) and right-lateral (RLAT) irradiation. Therefore, when investigating lateral geometries for electron exposure, it is not necessary to evaluate both directions independently. In general, conversion coefficients for lateral irradiation (LAT) were smaller than those for AP and PA. The difference between the AP and PA conversion coefficients and LAT became smaller with increasing incident energy; at 200 MeV the conversion coefficients were almost independent of the irradiation geometry. The agreement between the results of the present study and those of other studies was acceptable within the statistical uncertainties.

The LatHyS database for planetary plasma environment investigations: Overview and a case study of data/model comparisons

NASA Astrophysics Data System (ADS)

Modolo, R.; Hess, S.; Génot, V.; Leclercq, L.; Leblanc, F.; Chaufray, J.-Y.; Weill, P.; Gangloff, M.; Fedorov, A.; Budnik, E.; Bouchemit, M.; Steckiewicz, M.; André, N.; Beigbeder, L.; Popescu, D.; Toniutti, J.-P.; Al-Ubaidi, T.; Khodachenko, M.; Brain, D.; Curry, S.; Jakosky, B.; Holmström, M.

2018-01-01

We present the Latmos Hybrid Simulation (LatHyS) database, which is dedicated to the investigations of planetary plasma environment. Simulation results of several planetary objects (Mars, Mercury, Ganymede) are available in an online catalogue. The full description of the simulations and their results is compliant with a data model developped in the framework of the FP7 IMPEx project. The catalogue is interfaced with VO-visualization tools such AMDA, 3DView, TOPCAT, CLweb or the IMPEx portal. Web services ensure the possibilities of accessing and extracting simulated quantities/data. We illustrate the interoperability between the simulation database and VO-tools using a detailed science case that focuses on a three-dimensional representation of the solar wind interaction with the Martian upper atmosphere, combining MAVEN and Mars Express observations and simulation results.

New Theoretical Estimates of the Contribution of Unresolved Star-Forming Galaxies to the Extragalactic Gamma-Ray Background (EGB) as Measured by EGRET and the Fermi-LAT

NASA Technical Reports Server (NTRS)

Venters, Tonia M.

2011-01-01

We present new theoretical estimates of the contribution of unresolved star-forming galaxies to the extragalactic gamma-ray background (EGB) as measured by EGRET and the Fermi-LAT. We employ several methods for determining the star-forming galaxy contribution the the EGB, including a method positing a correlation between the gamma-ray luminosity of a galaxy and its rate of star formation as calculated from the total infrared luminosity, and a method that makes use of a model of the evolution of the galaxy gas mass with cosmic time. We find that depending on the model, unresolved star-forming galaxies could contribute significantly to the EGB as measured by the Fermi-LAT at energies between approx. 300 MeV and approx. few GeV. However, the overall spectrum of unresolved star-forming galaxies can explain neither the EGRET EGB spectrum at energies between 50 and 200 MeV nor the Fermi-LAT EGB spectrum at energies above approx. few GeV.

Eight γ-Ray Pulsars Discovered In Blind Frequency Searches Of Fermi Lat Data

DOE PAGES

Saz Parkinson, P. M.; Dormody, M.; Ziegler, M.; ...

2010-11-19

We report the discovery of eight γ-ray pulsars in blind frequency searches of ~650 source positions using the Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope. We present the timing models, light curves, and detailed spectral parameters of the new pulsars. PSRs J1023-5746, J1044-5737, J1413-5205, J1429-5911, and J1954+2836 are young (τ c < 100 kyr), energetic (more » $$\\dot{E} \\gtrsim 10^{36}$$ erg s–1), and located within the Galactic plane (|b| < 3°). The remaining three pulsars, PSRs J1846+0919, J1957+5033, and J2055+25, are less energetic, and located off the plane. Five pulsars are associated with sources included in the Fermi-LAT bright γ-ray source list, but only one, PSR J1413–6205, is clearly associated with an EGRET source. PSR J1023–5746 has the smallest characteristic age (τ c = 4.6 kyr) and is the most energetic ($$\\dot{E} = 1.1 \\times 10^{37}$$ erg s–1) of all γ-ray pulsars discovered so far in blind searches. By analyzing >100 ks of publicly available archival Chandra X-ray data, we have identified the likely counterpart of PSR J1023–5746 as a faint, highly absorbed source, CXOU J102302.8-574606. The large X-ray absorption indicates that this could be among the most distant γ-ray pulsars detected so far. PSR J1023–5746 is positionally coincident with the TeV source HESS J1023–575, located near the young stellar cluster Westerlund 2, while PSR J1954+2836 is coincident with a 4.3σ excess reported by Milagro at a median energy of 35 TeV. PSRs J1957+5033 and J2055+25 have the largest characteristic ages (τ c ~ 1 Myr) and are the least energetic ($$\\dot{E} \\sim 5\\times 10^{33}$$ erg s–1) of the newly discovered pulsars. We used recent XMM observations to identify the counterpart of PSR J2055+25 as XMMU J205549.4+253959. Deep radio follow-up observations of the eight pulsars resulted in no detections of pulsations and upper limits comparable to the faintest known radio pulsars, indicating that these

Fermi-Lat Observations of High-Energy Gamma-Ray Emission Toward the Galactic Center

NASA Technical Reports Server (NTRS)

Ajello, M.; Albert, A.; Atwood, W.B.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Brandt, T. J.;

Fermi-LAT and Suzaku Observations of the Radio Galaxy Centaurus B

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katsuta, Junichiro; /Stanford U., HEPL /KIPAC, Menlo Park; Tanaka, Y.T.

2012-08-17

CentaurusB is a nearby radio galaxy positioned in the Southern hemisphere close to the Galactic plane. Here we present a detailed analysis of about 43 months accumulation of Fermi-LAT data and of newly acquired Suzaku X-ray data for Centaurus B. The source is detected at GeV photon energies, although we cannot completely exclude the possibility that it is an artifact due to incorrect modeling of the bright Galactic diffuse emission in the region. The LAT image provides a weak hint of a spatial extension of the {gamma} rays along the radio lobes, which is consistent with the lack of sourcemore » variability in the GeV range. We note that the extension cannot be established statistically due to the low number of the photons. Surprisingly, we do not detect any diffuse emission of the lobes at X-ray frequencies, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. The broad-band modeling shows that the observed {gamma}-ray flux of the source may be produced within the lobes, if the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. This association would imply that efficient in-situ acceleration of the ultrarelativistic particles is occurring and that the lobes are dominated by the pressure from the relativistic particles. However, if the diffuse X-ray emission is much below the Suzaku upper limits, the observed {gamma}-ray flux is not likely to be produced within the lobes, but instead within the unresolved core of Centaurus B. In this case, the extended lobes could be dominated by the pressure of the magnetic field.« less

Fermi LAT detection of renewed GeV flaring activity from PKS 0426-380

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2012-12-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the BL Lac object PKS 0426-380 (also known as 2FGL J0428.6-3756, Nolan et al. 2012, ApJS, 199, 31, and RX J0428.6-3756) with radio coordinates R.A.: 67.16843 deg, Dec: -37.93877 deg, J2000 (Johnston et al. 1995, AJ, 110, 880) and redshift z=1.111 (Heidt et al....

Fermi LAT Detection of a GeV Flare from FSRQ PKS 2320-035

NASA Astrophysics Data System (ADS)

Carpenter, Bryce; Ojha, Roopesh

2013-04-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar PKS 2320-035 (also known as 2FGL J2323.6-0316, Nolan et al. 2012, ApJS, 199, 31). PKS 2320-035 has coordinates RA=23h23m31.9537s DEC=-03d17m05.023s, J2000, (Johnston et al. 1995, AJ, 110, 880) and redshift z=1.41 (Browne et al.

Fermi/LAT search for counterpart to the IceCube event 67093193 (run 127853)

NASA Astrophysics Data System (ADS)

Vianello, G.; Magill, J. D.; Omodei, N.; Kocevski, D.; Ajello, M.; Buson, S.; Krauss, F.; Chiang, J.

2016-04-01

on behalf of the Fermi-LAT team: We have searched the Fermi Large Area Telescope data for a high-energy gamma-ray counterpart for the IceCube High Energy Starting Event (HESE) 67093193, detected in run 127853 on 2016-04-27 05:52:32.00 UT (AMON GCN notice rev. 2, http://gcn.gsfc.nasa.gov/notices_amon/67093193_127853.amon . See http://gcn.gsfc.nasa.gov/doc/Public_Doc_AMON_IceCube_GCN_Alerts_v2.pdf for a description of HESE events and related GCN notices).

TOMOGRAPHY OF THE FERMI-LAT γ-RAY DIFFUSE EXTRAGALACTIC SIGNAL VIA CROSS CORRELATIONS WITH GALAXY CATALOGS

DOE PAGES

Xia, Jun-Qing; Cuoco, Alessandro; Branchini, Enzo; ...

2015-03-24

Building on our previous cross-correlation analysis (Xia et al. 2011) between the isotropic γ-ray background (IGRB) and different tracers of the large-scale structure of the universe, we update our results using 60 months of data from the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope (Fermi). For this study, we perform a cross-correlation analysis both in configuration and spherical harmonics space between the IGRB and objects that may trace the astrophysical sources of the IGRB: QSOs in the Sloan Digital Sky Survey (SDSS) DR6, the SDSS DR8 Main Galaxy Sample, luminous red galaxies (LRGs) in the SDSS catalog, infrared-selected galaxies in the Two Micron All Sky Survey (2MASS), and radio galaxies in the NRAO VLA Sky Survey (NVSS). The benefit of correlating the Fermi-LAT signal with catalogs of objects at various redshifts is to provide tomographic information on the IGRB, which is crucial in separating the various contributions and clarifying its origin. The main result is that, unlike in our previous analysis, we now observe a significant (>3.5σ) cross-correlation signal on angular scales smaller than 1° in the NVSS, 2MASS, and QSO cases and, at lower statistical significance (~3.0σ), with SDSS galaxies. The signal is stronger in two energy bands, E > 0.5 GeV and E > 1 GeV, but it is also seen at E > 10 GeV. No cross-correlation signal is detected between Fermi data and the LRGs. These results are robust against the choice of the statistical estimator, estimate of errors, map cleaning procedure, and instrumental effects. Finally, we test the hypothesis that the IGRB observed by Fermi-LAT originates from the summed contributions of three types of unresolved extragalactic sources: BL Lacertae objects (BL Lacs), flat spectrum radio quasars (FSRQs), and star-forming galaxies (SFGs). Finally, we find that a model in which the IGRB is mainly produced by SFGs (more » $$72_{-37}^{+23}$$% with 2σ errors), with BL Lacs and FSRQs giving a

Fermi-LAT Detection of Gravitational Lens Delayed Gamma-Ray Flares from Blazar B0218+357

NASA Technical Reports Server (NTRS)

Cheung, C. C.; Larsson, S.; Scargle, J. D.; Amin, M. A.; Blandford, R. D.; Bulmash, D.; Chiang, J.; Ciprini, S.; Corbet, R. D. H.; Falco, E. E.;

Fermi LAT detection of a continuing increase of gamma-ray activity of CTA 102

NASA Astrophysics Data System (ADS)

Orienti, M.; D'Ammando, F.

2012-09-01

The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar CTA 102 (also known as 2FGL J2232.4+1143, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 338.1517038 deg, Dec: 11.7308067 deg (J2000, Johnston et al. 1995, AJ, 110, 880) at redshift z=1.037 (Schmidt 1965, ApJ, 141, 1295).

Enhanced high-energy gamma-ray emission from the microquasar Cygnus X-3 detected by Fermi/LAT

NASA Astrophysics Data System (ADS)

Loh, Alan; Corbel, Stephane

2017-02-01

Following the recent decrease of the hard X-ray emission from the high-mass X-ray binary Cygnus X-3 as seen by the Swift/Burst Alert Telescope (https://swift.gsfc.nasa.gov/results/transients/CygX-3/), the Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed significant gamma-ray emission originating from the microquasar.

Extending the Fermi-LAT data processing pipeline to the grid

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zimmer, S.; Arrabito, L.; Glanzman, T.

2015-05-12

The Data Handling Pipeline ("Pipeline") has been developed for the Fermi Gamma-Ray Space Telescope (Fermi) Large Area Telescope (LAT) which launched in June 2008. Since then it has been in use to completely automate the production of data quality monitoring quantities, reconstruction and routine analysis of all data received from the satellite and to deliver science products to the collaboration and the Fermi Science Support Center. Aside from the reconstruction of raw data from the satellite (Level 1), data reprocessing and various event-level analyses are also reasonably heavy loads on the pipeline and computing resources. These other loads, unlike Levelmore » 1, can run continuously for weeks or months at a time. Additionally, it receives heavy use in performing production Monte Carlo tasks.« less

Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines.

PubMed

Gomes, P; Soares-da-Silva, P

2002-03-15

The present study examined the functional characteristics of L-DOPA transporters in two functionally different clonal subpopulations of opossum kidney (OKLC and OKHC) cells. The uptake of L-DOPA was largely Na+-independent, though in OKHC cells a minor component (approximately 15%) required extracellular Na+. At least two Na+-independent transporters appear to be involved in L-DOPA uptake. One of these transporters has a broad specificity for small and large neutral amino acids, is stimulated by acid pH and inhibited by 2-aminobicyclo(2,2,l)-heptane-2-carboxylic acid (BCH; OKLC, Ki = 291 mM; OKHC, Ki = 380 mM). The other Na+-independent transporter binds neutral and basic amino acids and also recognizes the di-amino acid cystine. [14C]-L-DOPA efflux from OKLC and OKHC cells over 12 min corresponded to a small amount of intracellular [14C]-L-DOPA. L-Leucine, nonlabelled L-DOPA, BCH and L-arginine, stimulated the efflux of [14C]-L-DOPA in a Na+-independent manner. It is suggested that L-DOPA uses at least two major transporters, systems LAT-2 and b0,+. The transport of L-DOPA by LAT-2 corresponds to a Na+-independent transporter with a broad specificity for small and large neutral amino acids, stimulated by acid pH and inhibited by BCH. The transport of L-DOPA by system b0,+ is a Na+-independent transporter for neutral and basic amino acids that also recognizes cystine. LAT-2 was found equally important at the apical and basolateral membranes, whereas system b0,+ had a predominant distribution in apical membranes.

Fermi-LAT Observations of High-Energy Gamma-Ray Emission Toward the Galactic Center

DOE PAGES

Ajello, M.

2016-02-26

The Fermi Large Area Telescope (LAT) has provided the most detailed view to date of the emission towards the Galactic centre (GC) in high-energy γ-rays. This paper describes the analysis of data taken during the first 62 months of the mission in the energy range 1 - 100 GeV from a 15° X15° region about the direction of the GC, and implications for the interstellar emissions produced by cosmic ray (CR) particles interacting with the gas and radiation fields in the inner Galaxy and for the point sources detected. Specialised interstellar emission models (IEMs) are constructed that enable separation ofmore » the γ-ray emission from the inner ~ 1 kpc about the GC from the fore- and background emission from the Galaxy. Based on these models, the interstellar emission from CR electrons interacting with the interstellar radiation field via the inverse Compton (IC) process and CR nuclei inelastically scattering off the gas producing γ-rays via π⁰ decays from the inner ~ 1 kpc is determined. The IC contribution is found to be dominant in the region and strongly enhanced compared to previous studies. A catalog of point sources for the 15 °X 15 °region is self-consistently constructed using these IEMs: the First Fermi–LAT Inner Galaxy point source Catalog (1FIG). The spatial locations, fluxes, and spectral properties of the 1FIG sources are presented, and compared with γ-ray point sources over the same region taken from existing catalogs, including the Third Fermi–LAT Source Catalog (3FGL). In general, the spatial density of 1FIG sources differs from those in the 3FGL, which is attributed to the different treatments of the interstellar emission and energy ranges used by the respective analyses. Three 1FIG sources are found to spatially overlap with supernova remnants (SNRs) listed in Green’s SNR catalog; these SNRs have not previously been associated with high-energy γ-ray sources. Most 3FGL sources with known multi-wavelength counterparts are also found

QUANTIFYING THE INTERSTELLAR MEDIUM AND COSMIC RAYS IN THE MBM 53, 54, AND 55 MOLECULAR CLOUDS AND THE PEGASUS LOOP USING FERMI -LAT GAMMA-RAY OBSERVATIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mizuno, T.; Abdollahi, S.; Fukui, Y.

A study of the interstellar medium (ISM) and cosmic rays (CRs) using Fermi Large Area Telescope (LAT) data, in a region encompassing the nearby molecular clouds MBM 53, 54, and 55 and a farinfrared loop-like structure in Pegasus, is reported. By comparing Planck dust thermal emission model with Fermi -LAT γ-ray data, it was found that neither the dust radiance (R) nor the dust opacity at 353 GHz (τ353) were proportional to the total gas column density N(Htot) primarily because N(Htot)/R and N(Htot)/τ353 depend on the dust temperature (Td). The N(Htot) distribution was evaluated using γ-ray data by assuming themore » regions of high Td to be dominated by optically thin atomic hydrogen (HI) and by employing an empirical linear relation of N(Htot)/R to Td. It was determined that the mass of the gas not traced by the 21-cm or 2.6-mm surveys is ~25% of the mass of HI in the optically thin case and is larger than the mass of the molecular gas traced by carbon monoxide by a factor of up to 5. The measured γ-ray emissivity spectrum is consistent with a model based on CR spectra measured at the Earth and the nuclear enhancement factor of ≤1.5. It is, however, lower than local HI emissivities reported by previous Fermi -LAT studies employing different analysis methods and assumptions on ISM properties by 15%–20% in energies below a few GeV, even if we take account of the statistical and systematic uncertainties. The origin of the discrepancy is also discussed.« less

QUANTIFYING THE INTERSTELLAR MEDIUM AND COSMIC RAYS IN THE MBM 53, 54, AND 55 MOLECULAR CLOUDS AND THE PEGASUS LOOP USING FERMI -LAT GAMMA-RAY OBSERVATIONS

DOE PAGES

Mizuno, T.; Abdollahi, S.; Fukui, Y.; ...

2016-12-20

A study of the interstellar medium (ISM) and cosmic rays (CRs) using Fermi Large Area Telescope (LAT) data, in a region encompassing the nearby molecular clouds MBM 53, 54, and 55 and a farinfrared loop-like structure in Pegasus, is reported. By comparing Planck dust thermal emission model with Fermi -LAT γ-ray data, it was found that neither the dust radiance (R) nor the dust opacity at 353 GHz (τ353) were proportional to the total gas column density N(Htot) primarily because N(Htot)/R and N(Htot)/τ353 depend on the dust temperature (Td). The N(Htot) distribution was evaluated using γ-ray data by assuming themore » regions of high Td to be dominated by optically thin atomic hydrogen (HI) and by employing an empirical linear relation of N(Htot)/R to Td. It was determined that the mass of the gas not traced by the 21-cm or 2.6-mm surveys is ~25% of the mass of HI in the optically thin case and is larger than the mass of the molecular gas traced by carbon monoxide by a factor of up to 5. The measured γ-ray emissivity spectrum is consistent with a model based on CR spectra measured at the Earth and the nuclear enhancement factor of ≤1.5. It is, however, lower than local HI emissivities reported by previous Fermi -LAT studies employing different analysis methods and assumptions on ISM properties by 15%–20% in energies below a few GeV, even if we take account of the statistical and systematic uncertainties. The origin of the discrepancy is also discussed.« less

Fermi LAT detection of renewed gamma-ray activity from the FSRQ PKS 2326-502

NASA Astrophysics Data System (ADS)

D'Ammando, F.; Torresi, E.

2012-06-01

The Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope has observed an increasing gamma-ray flux from a source positionally consistent with the Flat Spectrum Radio Quasar PKS 2326-502 (also known as 2FGL J2329.2-4956, Nolan et al. 2012, ApJS, 199, 31; R.A.=23:29:20.880 Dec.=-49:55:40.68, J2000.0, Costa and Loyola 1996, A&AS, 115, 75) at redshift z=0.518 (Jauncey et al. 1984, ApJ, 286, 498).

Evaluation of the Monotonic Lagrangian Grid and Lat-Long Grid for Air Traffic Management

NASA Technical Reports Server (NTRS)

Kaplan, Carolyn; Dahm, Johann; Oran, Elaine; Alexandrov, Natalia; Boris, Jay

2011-01-01

The Air Traffic Monotonic Lagrangian Grid (ATMLG) is used to simulate a 24 hour period of air traffic flow in the National Airspace System (NAS). During this time period, there are 41,594 flights over the United States, and the flight plan information (departure and arrival airports and times, and waypoints along the way) are obtained from an Federal Aviation Administration (FAA) Enhanced Traffic Management System (ETMS) dataset. Two simulation procedures are tested and compared: one based on the Monotonic Lagrangian Grid (MLG), and the other based on the stationary Latitude-Longitude (Lat- Long) grid. Simulating one full day of air traffic over the United States required the following amounts of CPU time on a single processor of an SGI Altix: 88 s for the MLG method, and 163 s for the Lat-Long grid method. We present a discussion of the amount of CPU time required for each of the simulation processes (updating aircraft trajectories, sorting, conflict detection and resolution, etc.), and show that the main advantage of the MLG method is that it is a general sorting algorithm that can sort on multiple properties. We discuss how many MLG neighbors must be considered in the separation assurance procedure in order to ensure a five-mile separation buffer between aircraft, and we investigate the effect of removing waypoints from aircraft trajectories. When aircraft choose their own trajectory, there are more flights with shorter duration times and fewer CD&R maneuvers, resulting in significant fuel savings.

Dark matter and pulsar model constraints from Galactic center Fermi/LAT γ-ray observations

NASA Astrophysics Data System (ADS)

Gordon, Chris; Macias, Oscar

2014-05-01

Employing Fermi/LAT γ-ray observations, several independent groups have found excess extended γ-ray emission at the Galactic center (GC). Both, annihilating dark matter (DM) or a population of ~ 103 unresolved millisecond pulsars (MSPs) are regarded as well motivated possible explanations. However, there is significant uncertainties in the diffuse Galactic background at the GC. We have performed a revaluation of these two models for the extended γ-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We found that a population of several thousand MSPs with parameters consistent with the average spectral shape of Fermi/LAT measured MSPs was able to fit the GC excess emission. For DM, we found that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and bb with a <σ v> of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.

Dark matter and pulsar model constraints from Galactic Center Fermi-LAT gamma-ray observations

NASA Astrophysics Data System (ADS)

Gordon, Chris; Macías, Oscar

2013-10-01

Employing Fermi-LAT gamma-ray observations, several independent groups have found excess extended gamma-ray emission at the Galactic Center (GC). Both annihilating dark matter (DM) or a population of ˜103 unresolved millisecond pulsars (MSPs) are regarded as well-motivated possible explanations. However, there are significant uncertainties in the diffuse galactic background at the GC. We have performed a revaluation of these two models for the extended gamma-ray source at the GC by accounting for the systematic uncertainties of the Galactic diffuse emission model. We also marginalize over point-source and diffuse background parameters in the region of interest. We show that the excess emission is significantly more extended than a point source. We find that the DM (or pulsar-population) signal is larger than the systematic errors and therefore proceed to determine the sectors of parameter space that provide an acceptable fit to the data. We find that a population of 1000-2000 MSPs with parameters consistent with the average spectral shape of Fermi-LAT measured MSPs is able to fit the GC excess emission. For DM, we find that a pure τ+τ- annihilation channel is not a good fit to the data. But a mixture of τ+τ- and bb¯ with a ⟨σv⟩ of order the thermal relic value and a DM mass of around 20 to 60 GeV provides an adequate fit.

EIGHT {gamma}-RAY PULSARS DISCOVERED IN BLIND FREQUENCY SEARCHES OF FERMI LAT DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saz Parkinson, P. M.; Dormody, M.; Ziegler, M.

2010-12-10

We report the discovery of eight {gamma}-ray pulsars in blind frequency searches of {approx}650 source positions using the Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope. We present the timing models, light curves, and detailed spectral parameters of the new pulsars. PSRs J1023-5746, J1044-5737, J1413-5205, J1429-5911, and J1954+2836 are young ({tau}{sub c} < 100 kyr), energetic (E-dot {approx}>10{sup 36} erg s{sup -1}), and located within the Galactic plane (|b| < 3{sup 0}). The remaining three pulsars, PSRs J1846+0919, J1957+5033, and J2055+25, are less energetic, and located off the plane. Five pulsars are associated with sources included inmore » the Fermi-LAT bright {gamma}-ray source list, but only one, PSR J1413-6205, is clearly associated with an EGRET source. PSR J1023-5746 has the smallest characteristic age ({tau}{sub c} = 4.6 kyr) and is the most energetic (E-dot = 1.1x10{sup 37} erg s{sup -1}) of all {gamma}-ray pulsars discovered so far in blind searches. By analyzing >100 ks of publicly available archival Chandra X-ray data, we have identified the likely counterpart of PSR J1023-5746 as a faint, highly absorbed source, CXOU J102302.8-574606. The large X-ray absorption indicates that this could be among the most distant {gamma}-ray pulsars detected so far. PSR J1023-5746 is positionally coincident with the TeV source HESS J1023-575, located near the young stellar cluster Westerlund 2, while PSR J1954+2836 is coincident with a 4.3{sigma} excess reported by Milagro at a median energy of 35 TeV. PSRs J1957+5033 and J2055+25 have the largest characteristic ages ({tau}{sub c} {approx} 1 Myr) and are the least energetic (E-dot {approx}5x10{sup 33} erg s{sup -1}) of the newly discovered pulsars. We used recent XMM observations to identify the counterpart of PSR J2055+25 as XMMU J205549.4+253959. Deep radio follow-up observations of the eight pulsars resulted in no detections of pulsations and upper limits comparable to the

Deep Morphological and Spectral Study of the SNR RCW 86 with Fermi-LAT

NASA Technical Reports Server (NTRS)

Ajello, M.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; Bonino, R.; Bottacini, E.; Brandt, T. J.;

50 CFR Table 2c to Part 660... - Sablefish North of 36° N. lat. Allocations, 2014 and Beyond

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Sablefish North of 36° N. lat. Allocations, 2014 and Beyond 2c Table 2c to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED...

Constraints onthe bulk Lorentz factor of gamma-ray burstswith the detection rate by Fermi LAT

NASA Astrophysics Data System (ADS)

Chen, Ye; Liu, Ruo-Yu; Wang, Xiang-Yu

2018-07-01

The bulk Lorentz factor (Γ) of the outflow is an essential parameter for understanding the physics of gamma-ray burst (GRB). Informations about the Lorentz factors of some individual GRBs have been obtained from the spectral features of the high-energy gamma-ray emissions (>100 MeV), assuming that the spectral breaks or cutoffs are due to the pair-production attenuation (i.e. γγ → e+e-). In this paper, we attempt to interpret the dependence of the Large Area Telescope (LAT) detection rate of GRBs on the number of high-energy gamma-rays, taking into account the attenuation effect. We first simulate a long-GRB sample with Monte Carlo method using the luminosity function, rate distribution with redshift, and properties of the GRB spectrum. To characterize the distribution of the Lorentz factors, we assume that the Lorentz factors follow the relation Γ =Γ _0E_{iso, 52}k, where Eiso,52 is the isotropic photon energy in unit of 1052 erg. After taking into account the attenuation effect related with the above Lorentz factor distribution, we are able to reproduce the LAT-detected rate of GRBs as the function of the number of gamma-rays for suitable choice of the values of Γ0 and k. The result suggests that the distribution of the bulk Lorentz factor for the majority of GRBs is in the range of 50-250.

New Fermi-LAT event reconstruction reveals more high-energy gamma rays from gamma-ray bursts

DOE PAGES

Atwood, W. B.; Baldini, L.; Bregeon, J.; ...

2013-08-19

Here, based on the experience gained during the four and a half years of the mission, the Fermi-LAT Collaboration has undertaken a comprehensive revision of the event-level analysis going under the name of Pass 8. Although it is not yet finalized, we can test the improvements in the new event reconstruction with the special case of the prompt phase of bright gamma-ray bursts (GRBs), where the signal-to-noise ratio is large enough that loose selection cuts are sufficient to identify gamma rays associated with the source. Using the new event reconstruction, we have re-analyzed 10 GRBs previously detected by the Largemore » Area Telescope (LAT) for which an X-ray/optical follow-up was possible and found four new gamma rays with energies greater than 10 GeV in addition to the seven previously known. Among these four is a 27.4 GeV gamma ray from GRB 080916C, which has a redshift of 4.35, thus making it the gamma ray with the highest intrinsic energy (~147 GeV) detected from a GRB. We present here the salient aspects of the new event reconstruction and discuss the scientific implications of these new high-energy gamma rays, such as constraining extragalactic background light models, Lorentz invariance violation tests, the prompt emission mechanism, and the bulk Lorentz factor of the emitting region.« less

Constraints on cosmological dark matter annihilation from the Fermi-LAT isotropic diffuse gamma-ray measurement

DOE PAGES

Abdo, A. A.; Ackermann, M.; Ajello, M.; ...

2010-04-01

The first published Fermi large area telescope (Fermi-LAT) measurement of the isotropic diffuse gamma-ray emission is in good agreement with a single power law, and is not showing any signature of a dominant contribution from dark matter sources in the energy range from 20 to 100 GeV. Here, we use the absolute size and spectral shape of this measured flux to derive cross section limits on three types of generic dark matter candidates: annihilating into quarks, charged leptons and monochromatic photons. Predicted gamma-ray fluxes from annihilating dark matter are strongly affected by the underlying distribution of dark matter, and bymore » using different available results of matter structure formation we assess these uncertainties. We also quantify how the dark matter constraints depend on the assumed conventional backgrounds and on the Universe's transparency to high-energy gamma-rays. In reasonable background and dark matter structure scenarios (but not in all scenarios we consider) it is possible to exclude models proposed to explain the excess of electrons and positrons measured by the Fermi-LAT and PAMELA experiments. Derived limits also start to probe cross sections expected from thermally produced relics (e.g. in minimal supersymmetry models) annihilating predominantly into quarks. Finally, for the monochromatic gamma-ray signature, the current measurement constrains only dark matter scenarios with very strong signals.« less

Fermi LAT detection of a GeV flare from the blazar PKS 0250-225

NASA Astrophysics Data System (ADS)

Dutka, Michael; Ojha, Roopesh

2012-11-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar PKS 0250-225 (also known as 2FGL J0252.7-2218, Nolan et al. 2012 ApJS, 199, 31). PKS 0250-225 has the coordinates RA=02h52m47.9536s, DEC=-22d19m25.465s, J2000, (Beasley et al. 2002 ApJS, 141, 13) and redshift z=1.419 (Shaw et al.

Fermi LAT detection of a new gamma-ray flare from FSRQ PKS 0502+049

NASA Astrophysics Data System (ADS)

Ojha, Roopesh; Dutka, Michael

2013-03-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar PKS 0502+049 (also known as 2FGL J0505.5+0501, Nolan et al. 2012 ApJS, 199, 31). PKS 0502+049 has coordinates RA=05h05m23.1847s DEC=+04d59m42.725s, J2000, (Johnston et al. 1995, AJ, 110, 880) and redshift z=0.954 (Drinkwater et al.

The radio and optical counterpart of the new Fermi LAT flaring source J0109+6134

NASA Astrophysics Data System (ADS)

Paredes, J. M.; Martí, J.; Peracaula, M.

2010-02-01

Following the recent ATELs #2414, #2416 and #2420 concerning the Fermi-LAT, AGILE and Swift/XRT consistent detections of the new gamma-ray flaring source J0109+6134, we wish to remind that the proposed radio counterpart (VCS2 J0109+6133/GT 0106+613) was extensively observed nearly two decades ago by different authors in the context of the GT catalogue of Galactic Plane radio sources (Taylor and Gregory 1983, AJ, 88, 1784; Gregory and Taylor 1986, AJ 92, 371).

Fermi LAT detection of an increase of gamma-ray activity of S5 1044+71

NASA Astrophysics Data System (ADS)

D'Ammando, F.; Orienti, M.

2014-01-01

The Large Area Telescope (LAT), on board the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the flat spectrum radio quasar S5 1044+71 (also known as 2FGL J1048.3+7144, Nolan et al. 2012, ApJS, 199, 31) with radio coordinates R.A.: 162.1150829 deg, Dec: 71.7266494 deg (J2000; Johnston et al. 1995, AJ, 110, 880) at redshift z=1.15 (Polatidis et al.

LAT1 targeted delivery of methionine based imaging probe derived from M(III) metal ions for early diagnosis of proliferating tumours using molecular imaging modalities.

PubMed

Hazari, Puja Panwar; Prakash, Surbhi; Meena, Virendra K; Jaswal, Ambika; Khurana, Harleen; Mishra, Surabhi Kirti; Bhonsle, Hemanth Kumar; Singh, Lokendra; Mishra, Anil K

2015-01-01

We investigated the potential of DTPA-bis(Methionine), a target specific amino acid based probe for detection of L-type amino acid transporters (LAT1) known to over express in proliferating tumours using multimodality imaging. The ligand, DTPA-bis(Met) was readily converted to lanthanide complexes and was found capable of targeting cancer cells using multimodality imaging. DTPA-bis(Met) complexes were synthesized and characterized by mass spectroscopy. MR longitudinal relaxivity, r₁ = 4.067 ± 0.31 mM⁻¹s⁻¹ and transverse relaxivity, r₂ = 8.61 ± 0.07 mM⁻¹s⁻¹ of Gd(III)-DTPA-bis(Met) were observed at pH 7.4 at 7 T. Bright, localized fluorescence of Eu(III)-DTPA-bis(Met) was observed with standard microscopy and displacement studies indicated ligand functionality. K(D) value determined for Eu(III)-DTPA-bis(Met) on U-87 MG cells was found to be 17.3 pM and showed appreciable fluorescence within the cells. Radio HPLC showed a radiochemical purity more than 95% (specific activity = 400-500 MBq/μmol, labelling efficiency 78 %) for ⁶⁸Ga(III)-DTPA-bis(Met). Pre-treatment of xenografted U-87 MG athymic mice with ⁶⁸Ga(III)-DTPA-bis(Met) following unlabelled L-methionine administration reduced tumour uptake by 10-folds in Micro PET. These data support the specific binding of ⁶⁸Ga(III)-DTPA-bis(Met) to the LAT1 transporter. To summarize, this agent possesses high stability in biological environment and exhibits effective interaction with its LAT1 transporters giving high accumulation in tumour area, excellent tumour/non-tumour ratio and low non-specific retention in vivo.

The missing GeV γ-ray binary: Searching for HESS J0632+057 with Fermi-LAT

DOE PAGES

Caliandro, G. A.; Hill, A. B.; Torres, D. F.; ...

2013-09-25

The very high energy (VHE; >100 GeV) source HESS J0632+057 has been recently confirmed as a γ-ray binary, a subclass of the high-mass X-ray binary population, through the detection of an orbital period of 321 d. We performed a deep search for the emission of HESS J0632+057 in the GeV energy range using data from the Fermi Large Area Telescope (LAT). The analysis was challenging due to the source being located in close proximity to the bright γ-ray pulsar PSR J0633+0632 and lying in a crowded region of the Galactic plane where there is prominent diffuse emission. We formulated amore » Bayesian block algorithm adapted to work with weighted photon counts, in order to define the off-pulse phases of PSR J0633+0632. A detailed spectral-spatial model of a 5° circular region centred on the known location of HESS J0632+057 was generated to accurately model the LAT data. No significant emission from the location of HESS J0632+057 was detected in the 0.1–100 GeV energy range integrating over ~3.5 yr of data, with a 95 per cent flux upper limit of F0.1-100 GeV < 3 × 10 –8 ph cm –2 s –1. A search for emission over different phases of the orbit also yielded no significant detection. A search for source emission on shorter time-scales (days–months) did not yield any significant detections. We also report the results of a search for radio pulsations using the 100-m Green Bank Telescope. No periodic signals or individual dispersed bursts of a likely astronomical origin were detected. We estimated the flux density limit of < 90/40 μJy at 2/9 GHz. Furthermore, the LAT flux upper limits combined with the detection of HESS J0632+057 in the 136–400 TeV energy band by the MAGIC collaboration imply that the VHE spectrum must turn over at energies <136 GeV placing constraints on any theoretical models invoked to explain the γ-ray emission.« less

Fermi-LAT detection of ongoing gamma-ray activity from the new gamma-ray source Fermi J1654-1055 (PMN J1632-1052)

NASA Astrophysics Data System (ADS)

Kocevski, D.; Ajello, M.; Buson, S.; Buehler, R.; Giomi, M.

2016-02-01

During the week between February 8 and 15, 2016, the Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, observed gamma-ray activity from a new transient source, Fermi J1654-1055.

Fermi LAT detection of renewed strong GeV activity from the FSRQ 3C 279

NASA Astrophysics Data System (ADS)

Ojha, Roopesh; van Zyl, Pfesesani; Fermi Large Area Telescope Collaboration

2018-04-01

The Large Area Telescope (LAT), one of two instruments on the Fermi Gamma-ray Space Telescope, has observed an intense and hard gamma-ray flare from a source positionally consistent with the flat spectrum radio quasar 3C 279, also known as 3FGL J1256.1-0547 (Acero et al. 2015, ApJS, 218, 23), with radio coordinates R.A.: 12h56m11.1665s, Dec: -05d47m21.523s (J2000.0; Johnston et al. 1995, AJ, 110, 880).

Deep View of the Large Magellanic Cloud with Six Years of Fermi-LAT Observations

NASA Technical Reports Server (NTRS)

Ackermann, M.; Albert, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.;

Deep view of the Large Magellanic Cloud with six years of Fermi -LAT observations

DOE PAGES

Ackermann, M.

2016-01-27

Context. The nearby Large Magellanic Cloud (LMC) provides a rare opportunity of a spatially resolved view of an external star-forming galaxy in -rays. The LMC was detected at 0.1–100 GeV as an extended source with CGRO/EGRET and using early observations with the Fermi-LAT. The emission was found to correlate with massive star-forming regions and to be particularly bright towards 30 Doradus. Aims. Studies of the origin and transport of cosmic rays (CRs) in the Milky Way are frequently hampered by line-of-sight confusion and poor distance determination. The LMC offers a complementary way to address these questions by revealing whether andmore » how the -ray emission is connected to specific objects, populations of objects, and structures in the galaxy. Methods. We revisited the -ray emission from the LMC using about 73 months of Fermi-LAT P7REP data in the 0.2–100 GeV range. We developed a complete spatial and spectral model of the LMC emission, for which we tested several approaches: a simple geometrical description, template-fitting, and a physically driven model for CR-induced interstellar emission. Results. In addition to identifying PSR J0540-6919 through its pulsations, we find two hard sources positionally coincident with plerion N 157B and supernova remnant N 132D, which were also detected at TeV energies with H.E.S.S. We detect an additional soft source that is currently unidentified. Extended emission dominates the total flux from the LMC. It consists of an extended component of about the size of the galaxy and additional emission from three to four regions with degree-scale sizes. If it is interpreted as CRs interacting with interstellar gas, the large-scale emission implies a large-scale population of ~1–100GeV CRs with a density of ~30% of the local Galactic value. On top of that, the three to four small-scale emission regions would correspond to enhancements of the CR density by factors 2 to 6 or higher, possibly more energetic and younger

Deep morphological and spectral study of the SNR RCW 86 with Fermi-LAT

DOE PAGES

Ajello, M.

2016-03-02

RCW 86 is a young supernova remnant (SNR) showing a shell-type structure at several wavelengths and is thought to be an efficient cosmic-ray (CR) accelerator. Earlier Fermi Large Area Telescope results reported the detection of γ-ray emission coincident with the position of RCW 86 but its origin (leptonic or hadronic) remained unclear due to the poor statistics. Thanks to 6.5 years of data acquired by the Fermi -LAT and the new event reconstruction Pass 8, we report the significant detection of spatially extended emission coming from RCW 86. The spectrum is described by a power-law function with a very hardmore » photon index (Γ = 1.42±0.1 stat ±0.06 syst) in the 0.1–500 GeV range and an energy flux above 100 MeV of (2.91 ± 0.8stat ± 0.12 syst) × 10- 11 erg cm -2 s -1. Gathering all the available multiwavelength (MWL) data, we perform a broadband modeling of the nonthermal emission of RCW 86 to constrain parameters of the nearby medium and bring new hints about the origin of the γ-ray emission. For the whole SNR, the modeling favors a leptonic scenario in the framework of a two-zone model with an average magnetic field of 10.2 ± 0.7 μG and a limit on the maximum energy injected into protons of 2 × 10 49 erg for a density of 1 cm -3. In addition, parameter values are derived for the North-East (NE) and South-West (SW) regions of RCW 86, providing the first indication of a higher magnetic field in the SW region.« less

VizieR Online Data Catalog: First Fermi-LAT Inner Galaxy point source catalog (Ajello+, 2016)

NASA Astrophysics Data System (ADS)

Ajello, M.; Albert, A.; Atwood, W. B.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Bissaldi, E.; Blandford, R. D.; Bloom, E. D.; Bonino, R.; Bottacini, E.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caputo, R.; Caragiulo, M.; Caraveo, P. A.; Cecchi, C.; Chekhtman, A.; Chiang, J.; Chiaro, G.; Ciprini, S.; Cohen-Tanugi, J.; Cominsky, L. R.; Conrad, J.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Desiante, R.; di Venere, L.; Drell, P. S.; Favuzzi, C.; Ferrara, E. C.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giommi, P.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Gomez-Vargas, G. A.; Grenier, I. A.; Guiriec, S.; Gustafsson, M.; Harding, A. K.; Hewitt, J. W.; Hill, A. B.; Horan, D.; Jogler, T.; Johannesson, G.; Johnson, A. S.; Kamae, T.; Karwin, C.; Knodlseder, J.; Kuss, M.; Larsson, S.; Latronico, L.; Li, J.; Li, L.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Magill, J.; Maldera, S.; Malyshev, D.; Manfreda, A.; Mayer, M.; Mazziotta, M. N.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Moiseev, A. A.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nuss, E.; Ohno, M.; Ohsugi, T.; Omodei, N.; Orlando, E.; Ormes, J. F.; Paneque, D.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Raino, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Ritz, S.; Sanchez-Conde, M.; Parkinson, P. M. S.; Sgro, C.; Siskind, E. J.; Smith, D. A.; Spada, F.; Spandre, G.; Spinelli, P.; Suson, D. J.; Tajima, H.; Takahashi, H.; Thayer, J. B.; Torres, D. F.; Tosti, G.; Troja, E.; Uchiyama, Y.; Vianello, G.; Winer, B. L.; Wood, K. S.; Zaharijas, G.; Zimmer, S.

2018-01-01

The Fermi Large Area Telescope (LAT) has provided the most detailed view to date of the emission toward the Galactic center (GC) in high-energy γ-rays. This paper describes the analysis of data taken during the first 62 months of the mission in the energy range 1-100GeV from a 15°x15° region about the direction of the GC. Specialized interstellar emission models (IEMs) are constructed to enable the separation of the γ-ray emissions produced by cosmic ray particles interacting with the interstellar gas and radiation fields in the Milky Way into that from the inner ~1kpc surrounding the GC, and that from the rest of the Galaxy. A catalog of point sources for the 15°x15° region is self-consistently constructed using these IEMs: the First Fermi-LAT Inner Galaxy Point Source Catalog (1FIG). The spatial locations, fluxes, and spectral properties of the 1FIG sources are presented, and compared with γ-ray point sources over the same region taken from existing catalogs. After subtracting the interstellar emission and point-source contributions a residual is found. If templates that peak toward the GC are used to model the positive residual the agreement with the data improves, but none of the additional templates tried account for all of its spatial structure. The spectrum of the positive residual modeled with these templates has a strong dependence on the choice of IEM. (2 data files).

Fermi LAT detection of a gamma-ray flare from FSRQ S5 1044+71

NASA Astrophysics Data System (ADS)

Ojha, Roopesh; Carpenter, Bryce; Dutka, Michael

2013-04-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar S5 1044+71 (also known as 2FGL J1048.3+7144, Nolan et al. 2012, ApJS, 199, 31). Localization analysis has ruled out the nearby source 2FGL J1049.7+7240 as a possible counterpart. S5 1044+71 has coordinates RA=10h48m27.6199s DEC=+71d43m35.938s, J2000, (Johnston et al.

A statistical approach to recognize source classes for unassociated sources in the first Fermi-LAT catalog

DOE PAGES

Ackermann, M.; Ajello, M.; Allafort, A.; ...

2012-06-15

The Fermi Large Area Telescope (LAT) First Source Catalog (1FGL) provided spatial, spectral, and temporal properties for a large number of γ-ray sources using a uniform analysis method. After correlating with the most-complete catalogs of source types known to emit γ rays, 630 of these sources are "unassociated" (i.e., have no obvious counterparts at other wavelengths).We employ two statistical analyses of the primary γ-ray characteristics for these unassociated sources in an effort to correlate their γ-ray properties with the active galactic nucleus (AGN) and pulsar populations in 1FGL. Based on the correlation results, we classify 221 AGN-like and 134 pulsar-likemore » sources in the 1FGL unassociated sources. Furthermore, the results of these source "classifications" appear to match the expected source distributions, especially at high Galactic latitudes. While useful for planning future multiwavelength follow-up observations, these analyses use limited inputs, and their predictions should not be considered equivalent to "probable source classes" for these sources. We also discuss multiwavelength results and catalog cross-correlations to date, and provide new source associations for 229 Fermi-LAT sources that had no association listed in the 1FGL catalog. By validating the source classifications against these new associations, we find that the new association matches the predicted source class in ~80% of the sources.« less

A STATISTICAL APPROACH TO RECOGNIZING SOURCE CLASSES FOR UNASSOCIATED SOURCES IN THE FIRST FERMI-LAT CATALOG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Allafort, A.

The Fermi Large Area Telescope (LAT) First Source Catalog (1FGL) provided spatial, spectral, and temporal properties for a large number of {gamma}-ray sources using a uniform analysis method. After correlating with the most-complete catalogs of source types known to emit {gamma} rays, 630 of these sources are 'unassociated' (i.e., have no obvious counterparts at other wavelengths). Here, we employ two statistical analyses of the primary {gamma}-ray characteristics for these unassociated sources in an effort to correlate their {gamma}-ray properties with the active galactic nucleus (AGN) and pulsar populations in 1FGL. Based on the correlation results, we classify 221 AGN-like andmore » 134 pulsar-like sources in the 1FGL unassociated sources. The results of these source 'classifications' appear to match the expected source distributions, especially at high Galactic latitudes. While useful for planning future multiwavelength follow-up observations, these analyses use limited inputs, and their predictions should not be considered equivalent to 'probable source classes' for these sources. We discuss multiwavelength results and catalog cross-correlations to date, and provide new source associations for 229 Fermi-LAT sources that had no association listed in the 1FGL catalog. By validating the source classifications against these new associations, we find that the new association matches the predicted source class in {approx}80% of the sources.« less

A Statistical Approach to Recognizing Source Classes for Unassociated Sources in the First FERMI-LAT Catalog

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Allafort, A.; Antolini, E.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Berenji, B.;

A statistical approach to recognize source classes for unassociated sources in the first Fermi-LAT catalog

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Allafort, A.

The Fermi Large Area Telescope (LAT) First Source Catalog (1FGL) provided spatial, spectral, and temporal properties for a large number of γ-ray sources using a uniform analysis method. After correlating with the most-complete catalogs of source types known to emit γ rays, 630 of these sources are "unassociated" (i.e., have no obvious counterparts at other wavelengths).We employ two statistical analyses of the primary γ-ray characteristics for these unassociated sources in an effort to correlate their γ-ray properties with the active galactic nucleus (AGN) and pulsar populations in 1FGL. Based on the correlation results, we classify 221 AGN-like and 134 pulsar-likemore » sources in the 1FGL unassociated sources. Furthermore, the results of these source "classifications" appear to match the expected source distributions, especially at high Galactic latitudes. While useful for planning future multiwavelength follow-up observations, these analyses use limited inputs, and their predictions should not be considered equivalent to "probable source classes" for these sources. We also discuss multiwavelength results and catalog cross-correlations to date, and provide new source associations for 229 Fermi-LAT sources that had no association listed in the 1FGL catalog. By validating the source classifications against these new associations, we find that the new association matches the predicted source class in ~80% of the sources.« less

Three Millisecond Pulsars in Fermi LAT Unassociated Bright Sources

NASA Technical Reports Server (NTRS)

Ransom, S. M.; Ray, P. S.; Camilo, F.; Roberts, M. S. E.; Celik, O.; Wolff, M. T.; Cheung, C. C.; Kerr, M.; Pennucci, T.; DeCesar, M. E.;

Fermi LAT detection of a GeV flare from the BL Lac object Mrk 421

NASA Astrophysics Data System (ADS)

D'Ammando, F.; Orienti, M.

2012-07-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the BL Lac object Mrk 421 (also known as 2FGL J1104.4+3812, Nolan et al. 2012, ApJS, 199, 31; R.A.= 11h04m27.3139s, Dec.= +38d12m31.799s, J2000.0, Fey et al. 2004, AJ, 127, 3587) at redshift z=0.03 (De Vaucouleurs et al.

Space Detectors for Gamma Rays (100 MeV-100 GeV): from Egret to Fermi LAT

NASA Technical Reports Server (NTRS)

Thompson, David J.

2015-01-01

The design of spaceborne high-energy (E is greater than 100 MeV) gamma-ray detectors depends on two principal factors: (1) the basic physics of detecting and measuring the properties of the gamma rays; and (2) the constraints of operating such a detector in space for an extended period. Improvements in technology have enabled major advances in detector performance, as illustrated by two successful instruments, EGRET on the Compton Gamma Ray Observatory and LAT on the Fermi Gamma-ray Space Telescope.

KSC-08pd0610

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- NASA's Gamma-Ray Large Area Space Telescope, or GLAST, arrives at Kennedy Space Center in a shipping container aboard a truck to begin final preparations for launch. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0614

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility near the Kennedy Space Center, workers maneuver the shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, into place. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Reconstructing WIMP properties through an interplay of signal measurements in direct detection, Fermi-LAT, and CTA searches for dark matter

NASA Astrophysics Data System (ADS)

Roszkowski, Leszek; Sessolo, Enrico Maria; Trojanowski, Sebastian; Williams, Andrew J.

2016-08-01

We examine the projected ability to reconstruct the mass, scattering, and annihilation cross section of dark matter in the new generation of large underground detectors, XENON-1T, SuperCDMS, and DarkSide-G2, in combination with diffuse gamma radiation from expected 15 years of data from Fermi-LAT observation of 46 local spiral dwarf galaxies and projected CTA sensitivity to a signal from the Galactic Center. To this end we consider several benchmark points spanning a wide range of WIMP mass, different annihilation final states, and large enough event rates to warrant detection in one or more experiments. As previously shown, below some 100 GeV only direct detection experiments will in principle be able to reconstruct WIMP mass well. This may, in case a signal at Fermi-LAT is also detected, additionally help restricting σv and the allowed decay branching rates. In the intermediate range between some 100 GeV and up a few hundred GeV, direct and indirect detection experiments can be used in complementarity to ameliorate the respective determinations, which in individual experiments can at best be rather poor, thus making the WIMP reconstruction in this mass range very challenging. At large WIMP mass, ~ 1 TeV, CTA will have the ability to reconstruct mass, annihilation cross section, and the allowed decay branching rates to very good precision for the τ+τ- or purely leptonic final state, good for the W+W- case, and rather poor for bbar b. A substantial improvement can potentially be achieved by reducing the systematic uncertainties, increasing exposure, or by an additional measurement at Fermi-LAT that would help reconstruct the annihilation cross section and the allowed branching fractions to different final states.

Reconstructing WIMP properties through an interplay of signal measurements in direct detection, Fermi-LAT, and CTA searches for dark matter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roszkowski, Leszek; Sessolo, Enrico Maria; Trojanowski, Sebastian

2016-08-01

We examine the projected ability to reconstruct the mass, scattering, and annihilation cross section of dark matter in the new generation of large underground detectors, XENON-1T, SuperCDMS, and DarkSide-G2, in combination with diffuse gamma radiation from expected 15 years of data from Fermi-LAT observation of 46 local spiral dwarf galaxies and projected CTA sensitivity to a signal from the Galactic Center. To this end we consider several benchmark points spanning a wide range of WIMP mass, different annihilation final states, and large enough event rates to warrant detection in one or more experiments. As previously shown, below some 100 GeVmore » only direct detection experiments will in principle be able to reconstruct WIMP mass well. This may, in case a signal at Fermi-LAT is also detected, additionally help restricting σ v and the allowed decay branching rates. In the intermediate range between some 100 GeV and up a few hundred GeV, direct and indirect detection experiments can be used in complementarity to ameliorate the respective determinations, which in individual experiments can at best be rather poor, thus making the WIMP reconstruction in this mass range very challenging. At large WIMP mass, ∼ 1 TeV, CTA will have the ability to reconstruct mass, annihilation cross section, and the allowed decay branching rates to very good precision for the τ{sup +}τ{sup -} or purely leptonic final state, good for the W {sup +} W {sup -} case, and rather poor for b b-bar . A substantial improvement can potentially be achieved by reducing the systematic uncertainties, increasing exposure, or by an additional measurement at Fermi-LAT that would help reconstruct the annihilation cross section and the allowed branching fractions to different final states.« less

Discovery of GeV emission from the Circinus galaxy with the Fermi Large Area Telescope [Discovery of GeV emission from the Circinus galaxy with the Fermi-LAT

DOE PAGES

Hayashida, Masaaki; Stawarz, Łukasz; Cheung, Chi C.; ...

2013-12-03

We report the discovery of γ-ray emission from the Circinus galaxy using the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope. Circinus is a nearby (~4 Mpc) starburst with a heavily obscured Seyfert-type active nucleus, bipolar radio lobes perpendicular to the spiral disk, and kpc-scale jet-like structures. Our analysis of 0.1-100 GeV events collected during 4 yr of LAT observations reveals a significant (≃ 7.3σ) excess above the background. We find no indications of variability or spatial extension beyond the LAT point-spread function. A power-law model used to describe the 0.1-100 GeV γ-ray spectrum yields a fluxmore » of (18.8 ± 5.8) × 10 –9 photon cm –2 s –1 and photon index 2.19 ± 0.12, corresponding to an isotropic γ-ray luminosity of 3 × 10 40 erg s –1. This observed γ-ray luminosity exceeds the luminosity expected from cosmic-ray interactions in the interstellar medium and inverse Compton radiation from the radio lobes. Furthermore, the origin of the GeV excess requires further investigation.« less

Searching for Dark Matter annihilation in recently discovered Milky Way satellites with FERMI-LAT

DOE PAGES

Albert, A.; Anderson, B.; Bechtol, K.; ...

2017-01-06

Here, we search for excess γ-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using six years of data from the Fermi Large Area Telescope (LAT). Our sample of 45 stellar systems includes 28 kinematically confirmed dark-matter-dominated dwarf spheroidal galaxies (dSphs) and 17 recently discovered systems that have photometric characteristics consistent with the population of known dSphs. For each of these targets, the relative predicted γ-ray flux due to dark matter annihilation is taken from kinematic analysis if available, and estimated from a distance-based scaling relation otherwise, assuming that the stellar systems are DM-dominated dSphs. LAT data coincident with four of the newly discovered targets show a slight preference (eachmore » $$\\sim $$2σ local) for γ-ray emission in excess of the background. However, the ensemble of derived γ-ray flux upper limits for individual targets is consistent with the expectation from analyzing random blank-sky regions, and a combined analysis of the population of stellar systems yields no globally significant excess (global significance $$\\lt 1\\sigma $$). Our analysis has increased sensitivity compared to the analysis of 15 confirmed dSphs by Ackermann et al. The observed constraints on the DM annihilation cross section are statistically consistent with the background expectation, improving by a factor of ~2 for large DM masses ($${m}_{\\mathrm{DM},b\\bar{b}}\\gtrsim 1\\,\\mathrm{TeV}$$ and $${m}_{\\mathrm{DM},{\\tau }^{+}{\\tau }^{-}}\\gtrsim 70\\,\\mathrm{GeV}$$) and weakening by a factor of ~1.5 at lower masses relative to previously observed limits.« less

Searching for Dark Matter annihilation in recently discovered Milky Way satellites with FERMI-LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Albert, A.; Anderson, B.; Bechtol, K.

Here, we search for excess γ-ray emission coincident with the positions of confirmed and candidate Milky Way satellite galaxies using six years of data from the Fermi Large Area Telescope (LAT). Our sample of 45 stellar systems includes 28 kinematically confirmed dark-matter-dominated dwarf spheroidal galaxies (dSphs) and 17 recently discovered systems that have photometric characteristics consistent with the population of known dSphs. For each of these targets, the relative predicted γ-ray flux due to dark matter annihilation is taken from kinematic analysis if available, and estimated from a distance-based scaling relation otherwise, assuming that the stellar systems are DM-dominated dSphs. LAT data coincident with four of the newly discovered targets show a slight preference (eachmore » $$\\sim $$2σ local) for γ-ray emission in excess of the background. However, the ensemble of derived γ-ray flux upper limits for individual targets is consistent with the expectation from analyzing random blank-sky regions, and a combined analysis of the population of stellar systems yields no globally significant excess (global significance $$\\lt 1\\sigma $$). Our analysis has increased sensitivity compared to the analysis of 15 confirmed dSphs by Ackermann et al. The observed constraints on the DM annihilation cross section are statistically consistent with the background expectation, improving by a factor of ~2 for large DM masses ($${m}_{\\mathrm{DM},b\\bar{b}}\\gtrsim 1\\,\\mathrm{TeV}$$ and $${m}_{\\mathrm{DM},{\\tau }^{+}{\\tau }^{-}}\\gtrsim 70\\,\\mathrm{GeV}$$) and weakening by a factor of ~1.5 at lower masses relative to previously observed limits.« less

Fermi LAT detection of a GeV flare from the gravitationally lensed blazar S3 0218+35

NASA Astrophysics Data System (ADS)

Ciprini, S.

2012-08-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the blazar S3 0218+35 (also known as 2FGL J0221.0+3555, Nolan et al. 2012, ApJS, 199, 31, and B2 0218+35, OD 330, lens B0218+357) placed at radio coordinates R.A.: 35.27279 deg, Dec: +35.93715 deg.

Fermi LAT detection of renewed gamma-ray flaring activity from the radio galaxy NGC 1275 (Perseus A)

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2013-01-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed GeV gamma-ray flaring activity from a source positionally consistent with NGC 1275 (also known as 2FGL J0319.8+4130, Nolan et al. 2012, ApJS, 199, 31, as Perseus A and 3C 84) a radio galaxy located at the center of the Perseus galaxy cluster (see also Abdo et al. 2009, ApJ, 699, 31).

Deep view of the Large Magellanic Cloud with six years of Fermi-LAT observations

NASA Astrophysics Data System (ADS)

Ackermann, M.; Albert, A.; Atwood, W. B.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bellazzini, R.; Bissaldi, E.; Bloom, E. D.; Bonino, R.; Brandt, T. J.; Bregeon, J.; Bruel, P.; Buehler, R.; Caliandro, G. A.; Cameron, R. A.; Caragiulo, M.; Caraveo, P. A.; Cavazzuti, E.; Cecchi, C.; Charles, E.; Chekhtman, A.; Chiang, J.; Chiaro, G.; Ciprini, S.; Cohen-Tanugi, J.; Cutini, S.; D'Ammando, F.; de Angelis, A.; de Palma, F.; Desiante, R.; Digel, S. W.; Drell, P. S.; Favuzzi, C.; Ferrara, E. C.; Focke, W. B.; Franckowiak, A.; Fusco, P.; Gargano, F.; Gasparrini, D.; Giglietto, N.; Giordano, F.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Guillemot, L.; Guiriec, S.; Harding, A. K.; Hill, A. B.; Horan, D.; Jóhannesson, G.; Knödlseder, J.; Kuss, M.; Larsson, S.; Latronico, L.; Li, J.; Li, L.; Longo, F.; Loparco, F.; Lubrano, P.; Maldera, S.; Martin, P.; Mayer, M.; Mazziotta, M. N.; Michelson, P. F.; Mizuno, T.; Monzani, M. E.; Morselli, A.; Murgia, S.; Nuss, E.; Ohsugi, T.; Orienti, M.; Orlando, E.; Ormes, J. F.; Paneque, D.; Pesce-Rollins, M.; Piron, F.; Pivato, G.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Romani, R. W.; Sánchez-Conde, M.; Schulz, A.; Sgrò, C.; Siskind, E. J.; Smith, D. A.; Spada, F.; Spandre, G.; Spinelli, P.; Suson, D. J.; Takahashi, H.; Thayer, J. B.; Tibaldo, L.; Torres, D. F.; Tosti, G.; Troja, E.; Vianello, G.; Wood, M.; Zimmer, S.

2016-02-01

Context. The nearby Large Magellanic Cloud (LMC) provides a rare opportunity of a spatially resolved view of an external star-forming galaxy in γ-rays. The LMC was detected at 0.1-100 GeV as an extended source with CGRO/EGRET and using early observations with the Fermi-LAT. The emission was found to correlate with massive star-forming regions and to be particularly bright towards 30 Doradus. Aims: Studies of the origin and transport of cosmic rays (CRs) in the Milky Way are frequently hampered by line-of-sight confusion and poor distance determination. The LMC offers a complementary way to address these questions by revealing whether and how the γ-ray emission is connected to specific objects, populations of objects, and structures in the galaxy. Methods: We revisited the γ-ray emission from the LMC using about 73 months of Fermi-LAT P7REP data in the 0.2-100 GeV range. We developed a complete spatial and spectral model of the LMC emission, for which we tested several approaches: a simple geometrical description, template-fitting, and a physically driven model for CR-induced interstellar emission. Results: In addition to identifying PSR J0540-6919 through its pulsations, we find two hard sources positionally coincident with plerion N 157B and supernova remnant N 132D, which were also detected at TeV energies with H.E.S.S. We detect an additional soft source that is currently unidentified. Extended emission dominates the total flux from the LMC. It consists of an extended component of about the size of the galaxy and additional emission from three to four regions with degree-scale sizes. If it is interpreted as CRs interacting with interstellar gas, the large-scale emission implies a large-scale population of ~1-100 GeV CRs with a density of ~30% of the local Galactic value. On top of that, the three to four small-scale emission regions would correspond to enhancements of the CR density by factors 2 to 6 or higher, possibly more energetic and younger populations

Fermi LAT Observation of Centaurus a Radio Galaxy

NASA Astrophysics Data System (ADS)

Sahakyan, N. V.

2013-01-01

The results of analysis of approximately 3 year gamma-ray observations (August 2008-July 2011) of the core of radio galaxy Centaurus A with the Fermi Large Area Telescope (Fermi LAT) are presented. Binned likelihood analysis method applying to the data shows that below several GeV the spectrum can be described by a single power-law with photon index Γ = 2.73 ± 0.06. However, at higher energies the new data show significant excess above the extrapolation of the energy spectrum from low energies. The comparison of the corresponding Spectral Energy Distribution (SED) at GeV energies with the SED in the TeV energy band reported by the H.E.S.S. collaboration shows that we deal with two or perhaps even three components of gamma-radiation originating from different regions located within the central 10 kpc of Centaurus A. The analysis of gamma-ray data of Centaurus A lobe accumulated from the beginning of the operation until November 14, 2011 show extension of the HE gamma-ray emission beyond the WMAP radio image in the case of the Northern lobe [9]. The possible origins of gamma-rays from giant radio lobes of Centaurus A are discussed in the context of hadronic and leptonic scenarios.

Leptonic v.s. Hadronic Origin of the Gamma-ray Emission of the Fermi bubbles: Updates from Fermi-LAT and Forecast for Future Gamma-ray Telescopes

NASA Astrophysics Data System (ADS)

Su, Meng

2014-06-01

Data from the Fermi-LAT revealed two large gamma-ray bubbles, extending 50 degrees above and below the Galactic center, with a width of about 40 degrees in longitude. Such structure has been confirmed with multi-wavelength observations. With the most up to date Fermi-LAT data analysis, I will show that the Fermi bubbles have a spectral cutoff at both low energy < 1 GeV and high energy > 150 GeV. Detailed analysis of the spectral features will help us to distinguish the leptonic origin from hadronic origin of the gamma-ray emission from the bubbles. I will also describe what we expect to learn about the bubbles from future gamma-ray telescopes after Fermi, with an emphasis on Dark Matter Particle Explorer and Pair Production Gamma-ray Unit.

Constraints on WIMP annihilation for contracted dark matter in the inner Galaxy with the Fermi-LAT

DOE PAGES

Gómez-Vargas, Germán A.; Sánchez-Conde, Miguel A.; Huh, Ji -Haeng; ...

2013-10-16

Here, we derive constraints on parameters of generic dark matter candidates by comparing theoretical predictions with the gamma-ray emission observed by the Fermi-LAT from the region around the Galactic Center. Our analysis is conservative since it simply requires that the expected dark matter signal does not exceed the observed emission. The constraints obtained in the likely case that the collapse of baryons to the Galactic Center is accompanied by the contraction of the dark matter are strong. In particular, we find that for b b¯ and τ +τ – or W +W – dark matter annihilation channels, the upper limitsmore » on the annihilation cross section imply that the thermal cross section is excluded for a Weakly Interacting Massive Particle (WIMP) mass smaller than about 700 and 500 GeV, respectively. For the μ +μ – channel, where the effect of the inverse Compton scattering is important, depending on models of the Galactic magnetic field the exclusion of the thermal cross-section is for a WIMP mass smaller than about 150 to 400 GeV. The upper limits on the annihilation cross section of dark matter particles obtained are two orders of magnitude stronger than without contraction. In the latter case our results are compatible with the upper limits from the Galactic halo analysis reported by the Fermi-LAT collaboration for the case in which the same conservative approach without modeling of the astrophysical background is employed.« less

Constraints on the bulk Lorentz factor of gamma-ray bursts with the detection rate by Fermi LAT

NASA Astrophysics Data System (ADS)

Chen, Ye; Liu, Ruo-Yu; Wang, Xiang-Yu

2018-05-01

The bulk Lorentz factor(Γ) of the outflow is an essential parameter to understanding the physics of gamma-ray burst (GRB). Informations about the Lorentz factors of some individual GRBs have been obtained from the spectral features of the high-energy gamma-ray emissions (>100 MeV), assuming that the spectral breaks or cutoffs are due to the pair-production attenuation (i.e., γγ → e+e-). In this paper, we attempt to interpret the dependence of the LAT detection rate of GRBs on the number of high-energy gamma-rays, taking into account the attenuation effect. We first simulate a long-GRB sample with Monte Carlo method using the luminosity function, rate distribution with redshift and properties of the GRB spectrum. To characterize the distribution of the Lorentz factors, we assume that the Lorentz factors follow the relation Γ =Γ _0E_iso,52k, where Eiso, 52 is the isotropic photon energy in unit of 1052erg. After taking into account the attenuation effect related with the above Lorentz factor distribution, we are able to reproduce the LAT-detected rate of GRBs as the function of the number of gamma-rays for suitable choice of the values of Γ0 and k. The result suggests that the distribution of the bulk Lorentz factor for the majority of GRBs is in the range of 50 - 250.

Fermi-LAT detection of a gamma-ray flaring source in the vicinity of PKS 0507+17

NASA Astrophysics Data System (ADS)

D'Ammando, F.; Orienti, M.

2013-04-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with PKS 0507+17 (also known as 2FGL J0509.9+1802, Nolan et al. 2012, ApJS, 199, 31; R.A.= 05h10m02.3691s, Dec.= +18d00m41.582s, J2000.0, Johnston et al. 1995, AJ, 110, 880), a flat spectrum radio quasar at redshift z = 0.416 (Perlman et al.

Fermi-LAT detection of a gamma-ray flare from the high-z blazar PKS 2149-306

NASA Astrophysics Data System (ADS)

D'Ammando, F.; Orienti, M.

2013-01-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with PKS 2149-306 (also known as 2FGL J2151.5-3021, Nolan et al. 2012, ApJS, 199, 31; R.A.= 21h51m55.5239s, Dec.= -30d27m53.697s, J2000.0, Johnston et al. 1995, AJ, 110, 880), a flat spectrum radio quasar at redshift z = 2.345 (Wilkes 1986, MNRAS, 218, 331).

Fermi-LAT detection of a GeV gamma-ray flare from the blazar PKS 1313-333

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2016-01-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar PKS 1313-333 (also known as TXS 1313-333, OP -322, 2EG J1314-3430 and 3FGL J1316.0-3338), with radio counterpart position R.A.: 199.033275 deg, Dec.: -33.64977 deg, (J2000.0, Johnston et al. 1995, AJ, 110, 880) and with redshift z=1.210 (Jauncey et al. 1982, AJ, 87, 763).

LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.

PubMed

Milkereit, Ruth; Persaud, Avinash; Vanoaica, Liviu; Guetg, Adriano; Verrey, Francois; Rotin, Daniela

2015-05-22

Mammalian target of rapamycin 1 (mTORC1), a master regulator of cellular growth, is activated downstream of growth factors, energy signalling and intracellular essential amino acids (EAAs) such as Leu. mTORC1 activation occurs at the lysosomal membrane, and involves V-ATPase stimulation by intra-lysosomal EAA (inside-out activation), leading to activation of the Ragulator, RagA/B-GTP and mTORC1 via Rheb-GTP. How Leu enters the lysosomes is unknown. Here we identified the lysosomal protein LAPTM4b as a binding partner for the Leu transporter, LAT1-4F2hc (SLC7A5-SLAC3A2). We show that LAPTM4b recruits LAT1-4F2hc to lysosomes, leading to uptake of Leu into lysosomes, and is required for mTORC1 activation via V-ATPase following EAA or Leu stimulation. These results demonstrate a functional Leu transporter at the lysosome, and help explain the inside-out lysosomal activation of mTORC1 by Leu/EAA.

KSC-08pd0653

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, General Dynamics technicians secure NASA's Gamma-Ray Large Area Space Telescope, or GLAST, onto a work stand. There GLAST will undergo a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0613

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- The shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is moved into the Astrotech payload processing facility near the Kennedy Space Center to begin prelaunch activities. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0611

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- The shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is removed from the truck at the Astrotech payload processing facility near the Kennedy Space Center to begin prelaunch activities. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0612

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- The shipping container holding NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is removed from the truck at the Astrotech payload processing facility near the Kennedy Space Center to begin prelaunch activities. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Three millisecond pulsars in FERMI LAT unassociated bright sources

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ransom, S. M.; Ray, P. S.; Camilo, F.

2010-12-23

We searched for radio pulsars in 25 of the non-variable, unassociated sources in the Fermi LAT Bright Source List with the Green Bank Telescope at 820 MHz. Here, we report the discovery of three radio and γ-ray millisecond pulsars (MSPs) from a high Galactic latitude subset of these sources. All of the pulsars are in binary systems, which would have made them virtually impossible to detect in blind γ-ray pulsation searches. They seem to be relatively normal, nearby (≤2 kpc) MSPs. These observations, in combination with the Fermi detection of γ-rays from other known radio MSPs, imply that most, ifmore » not all, radio MSPs are efficient γ-ray producers. The γ-ray spectra of the pulsars are power law in nature with exponential cutoffs at a few GeV, as has been found with most other pulsars. The MSPs have all been detected as X-ray point sources. Finally, their soft X-ray luminosities of ~10 30-10 31 erg s –1 are typical of the rare radio MSPs seen in X-rays.« less

Cassiopeia A supernova

NASA Image and Video Library

2017-12-08

NASA's Fermi Closes on Source of Cosmic Rays New images from NASA's Fermi Gamma-ray Space Telescope show where supernova remnants emit radiation a billion times more energetic than visible light. The images bring astronomers a step closer to understanding the source of some of the universe's most energetic particles -- cosmic rays. This composite shows the Cassiopeia A supernova remnant across the spectrum: Gamma rays (magenta) from NASA's Fermi Gamma-ray Space Telescope; X-rays (blue, green) from NASA's Chandra X-ray Observatory; visible light (yellow) from the Hubble Space Telescope; infrared (red) from NASA's Spitzer Space Telescope; and radio (orange) from the Very Large Array near Socorro, N.M. Credit: NASA/DOE/Fermi LAT Collaboration, CXC/SAO/JPL-Caltech/Steward/O. Krause et al., and NRAO/AUI For more information: www.nasa.gov/mission_pages/GLAST/news/cosmic-rays-source.... NASA Goddard Space Flight Center is home to the nation's largest organization of combined scientists, engineers and technologists that build spacecraft, instruments and new technology to study the Earth, the sun, our solar system, and the universe. Follow us on Twitter Join us on Facebook

Search For Gamma-Ray Emission From X-Ray-Selected Seyfert Galaxies With Fermi -LAT

DOE PAGES

Ackermann, M.

2012-02-23

We report on a systematic investigation of the γ-ray properties of 120 hard Xray– selected Seyfert galaxies classified as ‘radio-quiet’ objects, utilizing the threeyear accumulation of Fermi–LAT data. Our sample of Seyfert galaxies is selected using the Swift–BAT 58-month catalog, restricting the analysis to the bright sources with average hard X-ray fluxes F14-195 keV ≥ 2.5 × 10 -11 erg cm -2 s -1 at high Galactic latitudes (|b| > 10°). In order to remove ‘radio-loud’ objects from the sample, we use the ‘hard X-ray radio loudness parameter’, RrX , defined as the ratio of the total 1.4 GHz radiomore » to 14 - 195 keV hard X-ray energy fluxes. Among 120 X-ray bright Seyfert galaxies with RrX < 10-4, we did not find a statistically significant γ-ray excess (TS > 25) positionally coincident with any target Seyferts, with possible exceptions of ESO 323–G077 and NGC 6814. The mean value of the 95% confidence level γ-ray upper limit for the integrated photon flux above 100 MeV from the analyzed Seyferts is ≃ 4×10 -9 ph cm -2 s -1 , and the upper limits derived for several objects reach ≃ 1 × 10 -9 ph cm -2 s -1 . Our results indicate that no prominent γ-ray emission component related to active galactic nucleus activity is present in the spectra of Seyferts around GeV energies. The Fermi–LAT upper limits derived for our sample probe the ratio of γ-ray to X-ray luminosities L /LX < 0.1, and even < 0.01 in some cases. The obtained results impose novel constraints on the models for high energy radiation of ‘radio-quiet’ Seyfert galaxies.« less

High-Energy Gamma-Ray Emission From Solar Flares: Summary of Fermi LAT Detections and Analysis of Two M-Class Flares

NASA Technical Reports Server (NTRS)

Ackermann, M.; Ajello, M.; Albert, A.; Allafort, A.; Baldini, L.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Bissaldi, E.;

SUZAKU X-RAY IMAGING OF THE EXTENDED LOBE IN THE GIANT RADIO GALAXY NGC 6251 ASSOCIATED WITH THE FERMI-LAT SOURCE 2FGL J1629.4+8236

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takeuchi, Y.; Kataoka, J.; Takahashi, Y.

2012-04-10

We report the results of a Suzaku X-ray imaging study of NGC 6251, a nearby giant radio galaxy with intermediate FR I/II radio properties. Our pointing direction was centered on the {gamma}-ray emission peak recently discovered with the Fermi Large Area Telescope (LAT) around the position of the northwest (NW) radio lobe 15 arcmin offset from the nucleus. After subtracting two 'off-source' pointings adjacent to the radio lobe and removing possible contaminants in the X-ray Imaging Spectrometer field of view, we found significant residual X-ray emission most likely diffuse in nature. The spectrum of the excess X-ray emission is wellmore » fitted by a power law with a photon index {Gamma} = 1.90 {+-} 0.15 and a 0.5-8 keV flux of 4 Multiplication-Sign 10{sup -13} erg cm{sup -2} s{sup -1}. We interpret this diffuse X-ray emission component as being due to inverse Compton upscattering of the cosmic microwave background photons by ultrarelativistic electrons within the lobe, with only a minor contribution from the beamed emission of the large-scale jet. Utilizing archival radio data for the source, we demonstrate by means of broadband spectral modeling that the {gamma}-ray flux of the Fermi-LAT source 2FGL J1629.4+8236 may well be accounted for by the high-energy tail of the inverse Compton continuum of the lobe. Thus, this claimed association of {gamma}-rays from the NW lobe of NGC 6251, together with the recent Fermi-LAT imaging of the extended lobes of Centaurus A, indicates that particles may be efficiently (re-)accelerated up to ultrarelativistic energies within extended radio lobes of nearby radio galaxies in general.« less

Fermi -Lat Observations Of The Geminga Pulsar

DOE PAGES

Abdo, A. A.

2010-08-09

We report on the Fermi-LAT observations of the Geminga pulsar, the second brightest non-variable GeV source in the γ-ray sky and the first example of a radio-quiet γ-ray pulsar. The observations cover one year, from the launch of the Fermi satellite through 2009 June 15. A data sample of over 60,000 photons enabled us to build a timing solution based solely on γ-rays. Timing analysis shows two prominent peaks, separated by Δphgr = 0.497 ± 0.004 in phase, which narrow with increasing energy. Pulsed γ-rays are observed beyond 18 GeV, precluding emission below 2.7 stellar radii because of magnetic absorption.more » The phase-averaged spectrum was fitted with a power law with exponential cutoff of spectral index Γ = (1.30 ± 0.01 ± 0.04), cutoff energy E 0 = (2.46 ± 0.04 ± 0.17) GeV, and an integral photon flux above 0.1 GeV of (4.14 ± 0.02 ± 0.32) × 10 –6 cm –2 s –1. The first uncertainties are statistical and the second ones are systematic. The phase-resolved spectroscopy shows a clear evolution of the spectral parameters, with the spectral index reaching a minimum value just before the leading peak and the cutoff energy having maxima around the peaks. The phase-resolved spectroscopy reveals that pulsar emission is present at all rotational phases. The spectral shape, broad pulse profile, and maximum photon energy favor the outer magnetospheric emission scenarios.« less

KSC-08pd0617

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility near the Kennedy Space Center, workers check NASA's Gamma-Ray Large Area Space Telescope, or GLAST, after removal of the shipping container. The workers will prepare for a complete checkout of the telescope's scientific instruments. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0615

NASA Image and Video Library

2008-03-04

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility near the Kennedy Space Center, the shipping container covering NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is lifted. Workers will prepare for a complete checkout of the telescope's scientific instruments. The GLAST will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0654

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, General Dynamics technicians secure NASA's Gamma-Ray Large Area Space Telescope, or GLAST, on a work stand as the overhead crane is lifted away. GLAST will undergo a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Fermi LAT detection of a GeV flare from the BL Lac object PKS 2233-148

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2012-06-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the BL Lac object PKS 2233-148 (also known as 2FGL J2236.5-1431, Nolan et al. 2012, ApJS, 199, 31, and OY -156) placed at R.A.: 339.1420296 deg, Dec.: -14.5561633 (J2000, Petrov et al. 2008, AJ, 136, 580). No redshift for the source has been measured up to now, demonstrating the BL Lac object character type of this source.

Fermi LAT detection of a GeV flare from the high redshift BL Lac object PKS 2131-021

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2012-08-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed gamma-ray flaring activity from a source positionally consistent with the BL Lac object PKS 2131-021 (also known as 2FGL J2133.8-0154, Nolan et al. 2012, ApJS, 199, 31, and 4C -02.81) placed at radio coordinates R.A.: 323.5429567 deg, Dec.: -1.8881217 deg (J2000, Johnston et al. 1995, AJ, 110, 880).

Decline and decadence in Iraq and Syria after the age of Avicenna? 'Abd al-Latīf al-Baghdādī (1162-1231) between myth and history.

PubMed

Joosse, N Peter; Pormann, Peter E

2010-01-01

'Abd al-Latīf al-Baghdādī's (d. 1231) work Book of the Two Pieces of Advice (Kitāb al Nasīhatayn) challenges the idea that Islamic medicine declined after the twelfth century AD. Moreover, it offers some interesting insights into the social history of medicine. 'Abd al-Latīf advocated using the framework of Greek medical epistemology to criticize the rationalist physicians of his day; he argued that female and itinerant practitioners, relying on experience, were superior to some rationalists. He lambasted contemporaneous medical education because it put too much faith in a restricted number of textbooks such as the Canon by Ibn Sīnā (Avicenna, d. 1037) or imperfect abridgments.

Fermi-LAT detection of a new gamma-ray flare from the NLSy1 PMN J0948+0022

NASA Astrophysics Data System (ADS)

D'Ammando, F.; Orienti, M.

2013-01-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with PMN J0948+0022 (also known as 2FGL J0948.8+0020, Nolan et al. 2012, ApJS, 199, 31; R.A.= 09h48m57.3201s, Dec.= +00d22'25.558", J2000, Beasley et al. 2002, ApJS, 141, 13), a radio-loud narrow-line Seyfert 1 at z=0.5846 (Sloan Digital Sky Survey, 2004, SDSS2.C).

Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

NASA Astrophysics Data System (ADS)

Di Mauro, M.; Manconi, S.; Zechlin, H.-S.; Ajello, M.; Charles, E.; Donato, F.

2018-04-01

The Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (| b| > 20^\\circ ), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10‑12 ph cm‑2 s‑1. With this method, we detect a flux break at (3.5 ± 0.4) × 10‑11 ph cm‑2 s‑1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ∼10‑11 ph cm‑2 s‑1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.

Cosmic Ray Studies with the Fermi Gamma-ray Space Telescope Large Area Telescope

NASA Technical Reports Server (NTRS)

Thompson, David J.; Baldini, L.; Uchiyama, Y.

2012-01-01

The Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope provides both direct and indirect measurements of galactic cosmic rays (CR). The LAT high-statistics observations of the 7 GeV - 1 TeV electron plus positron spectrum and limits on spatial anisotropy constrain models for this cosmic-ray component. On a galactic scale, the LAT observations indicate that cosmic-ray sources may be more plentiful in the outer Galaxy than expected or that the scale height of the cosmic-ray diffusive halo is larger than conventional models. Production of cosmic rays in supernova remnants (SNR) is supported by the LAT gamma-ray studies of several of these, both young SNR and those interacting with molecular clouds.

Cosmic Ray Studies with the Fermi Gamma-ray Space Telescope Large Area Telescope

NASA Technical Reports Server (NTRS)

Thompson, D. J.; Baldini, L.; Uchiyama, Y.

2011-01-01

The Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope provides both direct and indirect measurements of Galactic cosmic rays (CR). The LAT high-statistics observations of the 7 GeV - 1 TcV electron plus positron spectrum and limits on spatial anisotropy constrain models for this cosmic-ray component. On a Galactic scale, the LAT observations indicate that cosmic-ray sources may be more plentiful in the outer Galaxy than expected or that the scale height of the cosmic-ray diffusive halo is larger than conventional models. Production of cosmic rays in supernova remnants (SNR) is supported by the LAT gamma-ray studies of several of these, both young SNR and those interacting with molecular clouds.

Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

DOE PAGES

Di Mauro, M.; Manconi, S.; Zechlin, H. -S.; ...

2018-03-29

Here, the Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (more » $$|b| \\gt 20^\\circ $$), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10 –12 ph cm –2 s –1. With this method, we detect a flux break at (3.5 ± 0.4) × 10 –11 ph cm –2 s –1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ~10 –11 ph cm –2 s –1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.« less

Deriving the Contribution of Blazars to the Fermi-LAT Extragalactic γ-ray Background at E > 10 GeV with Efficiency Corrections and Photon Statistics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Di Mauro, M.; Manconi, S.; Zechlin, H. -S.

Here, the Fermi Large Area Telescope (LAT) Collaboration has recently released the Third Catalog of Hard Fermi-LAT Sources (3FHL), which contains 1556 sources detected above 10 GeV with seven years of Pass 8 data. Building upon the 3FHL results, we investigate the flux distribution of sources at high Galactic latitudes (more » $$|b| \\gt 20^\\circ $$), which are mostly blazars. We use two complementary techniques: (1) a source-detection efficiency correction method and (2) an analysis of pixel photon count statistics with the one-point probability distribution function (1pPDF). With the first method, using realistic Monte Carlo simulations of the γ-ray sky, we calculate the efficiency of the LAT to detect point sources. This enables us to find the intrinsic source-count distribution at photon fluxes down to 7.5 × 10 –12 ph cm –2 s –1. With this method, we detect a flux break at (3.5 ± 0.4) × 10 –11 ph cm –2 s –1 with a significance of at least 5.4σ. The power-law indexes of the source-count distribution above and below the break are 2.09 ± 0.04 and 1.07 ± 0.27, respectively. This result is confirmed with the 1pPDF method, which has a sensitivity reach of ~10 –11 ph cm –2 s –1. Integrating the derived source-count distribution above the sensitivity of our analysis, we find that (42 ± 8)% of the extragalactic γ-ray background originates from blazars.« less

FAST's Discovery of a New Millisecond Pulsar (MSP) toward the Fermi-LAT unassociated source 3FGL J0318.1+0252

NASA Astrophysics Data System (ADS)

Wang, Pei; Li, Di; Zhu, Weiwei; Zhang, Chengmin; Yan, Jun; Hou, Xian; Clark, Colin J.; Saz Parkinson, Pablo M.; Michelson, Peter F.; Ferrara, Elizabeth C.; Thompson, David J.; Smith, David A.; Ray, Paul S.; Kerr, Matthew; Shen, Zhiqiang; Wang, Na; Fermi-LAT Collaboration

2018-04-01

The Five hundred-meter Aperture Spherical radio Telescope (FAST), operated by the National Astronomical Observatories, Chinese Academy of Sciences, has discovered a radio millisecond pulsar (MSP) coincident with the unassociated gamma-ray source 3FGL J0318.1+0252 (Acero et al. 2015 ApJS, 218, 23), also known as FL8Y J0318.2+0254 in the recently released Fermi Large Area Telescope (LAT) 8-year Point Source List (FL8Y).

An adaptive-binning method for generating constant-uncertainty/constant-significance light curves with Fermi -LAT data

DOE PAGES

Lott, B.; Escande, L.; Larsson, S.; ...

2012-07-19

Here, we present a method enabling the creation of constant-uncertainty/constant-significance light curves with the data of the Fermi-Large Area Telescope (LAT). The adaptive-binning method enables more information to be encapsulated within the light curve than with the fixed-binning method. Although primarily developed for blazar studies, it can be applied to any sources. Furthermore, this method allows the starting and ending times of each interval to be calculated in a simple and quick way during a first step. The reported mean flux and spectral index (assuming the spectrum is a power-law distribution) in the interval are calculated via the standard LATmore » analysis during a second step. In the absence of major caveats associated with this method Monte-Carlo simulations have been established. We present the performance of this method in determining duty cycles as well as power-density spectra relative to the traditional fixed-binning method.« less

The Fermi-LAT gamma-ray excess at the Galactic Center in the singlet-doublet fermion dark matter model

NASA Astrophysics Data System (ADS)

Horiuchi, Shunsaku; Macias, Oscar; Restrepo, Diego; Rivera, Andrés; Zapata, Oscar; Silverwood, Hamish

2016-03-01

The singlet-doublet fermion dark matter model (SDFDM) provides a good DM candidate as well as the possibility of generating neutrino masses radiatively. The search and identification of DM requires the combined effort of both indirect and direct DM detection experiments in addition to the LHC. Remarkably, an excess of GeV gamma rays from the Galactic Center (GCE) has been measured with the Fermi Large Area Telescope (LAT) which appears to be robust with respect to changes in the diffuse galactic background modeling. Although several astrophysical explanations have been proposed, DM remains a simple and well motivated alternative. In this work, we examine the sensitivities of dark matter searches in the SDFDM scenario using Fermi-LAT, CTA, IceCube/DeepCore, LUX, PICO and LHC with an emphasis on exploring the regions of the parameter space that can account for the GCE. We find that DM particles present in this model with masses close to ~ 99 GeV and ~ (173-190) GeV annihilating predominantly into the W+W- channel and tbar t channel respectively, provide an acceptable fit to the GCE while being consistent with different current experimental bounds. We also find that much of the obtained parameter space can be ruled out by future direct search experiments like LZ and XENON-1T, in case of null results by these detectors. Interestingly, we show that the most recent data by LUX is starting to probe the best fit region in the SDFDM model.

KSC-08pd0649

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, General Dynamics technicians keep watch as NASA's Gamma-Ray Large Area Space Telescope, or GLAST, is lifted and begins moving toward the work stand in the foreground. There GLAST will undergo a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0643

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- A General Dynamics technician in the Astrotech payload processing facility releases a corner of the protective cover over NASA's Gamma-Ray Large Area Space Telescope, or GLAST, after its arrival. GLAST will be moved to a work stand in the facility for a complete checkout of the telescope's scientific instruments. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Fermi and Swift Gamma-Ray Burst Afterglow Population Studies

NASA Technical Reports Server (NTRS)

Racusin, J. L.; Oates, S. R.; Schady, P.; Burrows, D. N.; de Pasquale, M.; Donato, D.; Gehrels, N.; Koch, S.; McEnery, J.; Piran, T.;

Fermi and Swift Gamma-Ray Burst Afterglow Population Studies

NASA Technical Reports Server (NTRS)

Racusin, Judith I.

2011-01-01

The new and extreme population of GRBs detected by Fermi-LAT shows several new features in high energy gamma-rays that are providing interesting and unexpected clues into GRB prompt and afterglow emission mechanisms. Over the last 6 years, it has been Swift that has provided the robust data set of UV/optical and X-ray afterglow observations that opened many windows into components of GRB emission structure. The relationship between the LAT GRBs and the well studied, fainter, less energetic GRBs detected by Swift-BAT is only beginning to be explored by multi-wavelength studies. We explore the large sample of GRBs detected by BAT only, BAT and Fermi-GBM, and GBM and LAT, focusing on these samples separately in order to search for statistically significant differences between the populations, using only those GRBs with measured redshifts in order to physically characterize these objects. We disentangle which differences are instrumental selection effects versus intrinsic properties, in order to better understand the nature of the special characteristics of the LAT bursts.

Fermi and Swift Gamma-Ray Burst Afterglow Population Studies

NASA Technical Reports Server (NTRS)

Racusin, Judith L.; Oates, S. R.; Schady, P.; Burrows, D. N.; dePasquale, M.; Donato, D.; Gehrels, N.; Koch, S.; McEnery, J.; Piran, T.;

Fermi LAT detection of GeV flares from blazars PKS 0458-02 and B2 1144+40

NASA Astrophysics Data System (ADS)

Antolini, Elisa; Buson, Sara

2014-03-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from two sources positionally consistent with the flat spectrum radio quasars PKS 0458-02 (also known as 2FGL J0501.2-0155, Nolan et al. 2012 ApJS, 199, 31) and B2 1144+40 (also known as S4 1144+40 and 2FGL J1146.9+4000). PKS 0458-02 has the radio coordinates RA=05h01m12.8098s, Dec=-1d59m14.255s (J2000, Johnston et al.

Fermi-LAT detection of a GeV flare from the BL Lac object 1ES 2322-409

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2013-10-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with the BL Lac object 1ES 2322-409 (also know as 2FGL J2324.7-4042, Nolan et al. 2012, ApJS, 199, 31, and as 1FHL J2324.6-4041, Ackermann et al., ApJS, submitted, arXiv:1306.6772), with 2MASS counterpart coordinates, (J2000.0), R.A.: 351.18612 deg, Dec: -40.68036 deg (Mao 2011, New Ast., 16, 503).

Blazar flaring patterns (B-FlaP) classifying blazar candidate of uncertain type in the third Fermi-LAT catalogue by artificial neural networks

NASA Astrophysics Data System (ADS)

Chiaro, G.; Salvetti, D.; La Mura, G.; Giroletti, M.; Thompson, D. J.; Bastieri, D.

2016-11-01

The Fermi-Large Area Telescope (LAT) is currently the most important facility for investigating the GeV γ-ray sky. With Fermi-LAT, more than three thousand γ-ray sources have been discovered so far. 1144 (˜40 per cent) of the sources are active galaxies of the blazar class, and 573 (˜20 per cent) are listed as blazar candidate of uncertain type (BCU), or sources without a conclusive classification. We use the empirical cumulative distribution functions and the artificial neural networks for a fast method of screening and classification for BCUs based on data collected at γ-ray energies only, when rigorous multiwavelength analysis is not available. Based on our method, we classify 342 BCUs as BL Lacs and 154 as flat-spectrum radio quasars, while 77 objects remain uncertain. Moreover, radio analysis and direct observations in ground-based optical observatories are used as counterparts to the statistical classifications to validate the method. This approach is of interest because of the increasing number of unclassified sources in Fermi catalogues and because blazars and in particular their subclass high synchrotron peak objects are the main targets of atmospheric Cherenkov telescopes.

Fermi LAT detection of a GeV gamma-ray flare from blazar CGRaBS J0809+5341 (87GB 080551.6+535010)

NASA Astrophysics Data System (ADS)

Gasparrini, Dario

2017-10-01

The Large Area Telescope (LAT), one of two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray emission from a source positionally consistent with the flat spectrum radio quasar CGRaBS J0809+5341 (also known as 87GB 080551.6+535010, BZQ J0809+5341 and 3FGL J0809.5+5342) with radio coordinates (J2000) R.A.: 122.4238862 deg, Dec.: 53.6903033 deg (Petrov et al. 2011, AJ, 142, 89). This blazar has a redshift z = 2.133 (Healey et al. 2008, ApJS, 175, 97). Preliminary analysis indicates that on 2017 October 26, CGRaBS J0809+5341 was in a high state with a daily averaged gamma-ray flux (E > 100 MeV) of (0.23+/-0.15) X 10^-6 photons cm^-2 s^-1 (statistical uncertainty only), about 20 times greater than its four-year average flux reported in the third Fermi-LAT source catalog (3FGL, Acero et al. 2015, ApJS, 218, 23). Because Fermi operates in an all-sky scanning mode, regular gamma-ray monitoring of this source will continue.

SEARCH FOR GAMMA-RAY EMISSION FROM X-RAY-SELECTED SEYFERT GALAXIES WITH FERMI-LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ackermann, M.; Ajello, M.; Allafort, A.

We report on a systematic investigation of the {gamma}-ray properties of 120 hard X-ray-selected Seyfert galaxies classified as 'radio-quiet' objects, utilizing the three-year accumulation of Fermi Large Area Telescope (LAT) data. Our sample of Seyfert galaxies is selected using the Swift Burst Alert Telescope 58 month catalog, restricting the analysis to the bright sources with average hard X-ray fluxes F{sub 14-195keV} {>=} 2.5 Multiplication-Sign 10{sup -11} erg cm{sup -2} s{sup -1} at high Galactic latitudes (|b| > 10 Degree-Sign ). In order to remove 'radio-loud' objects from the sample, we use the 'hard X-ray radio loudness parameter', R{sub rX}, definedmore » as the ratio of the total 1.4 GHz radio to 14-195 keV hard X-ray energy fluxes. Among 120 X-ray bright Seyfert galaxies with R{sub rX} <10{sup -4}, we did not find a statistically significant {gamma}-ray excess (TS > 25) positionally coincident with any target Seyferts, with possible exceptions of ESO 323-G077 and NGC 6814. The mean value of the 95% confidence level {gamma}-ray upper limit for the integrated photon flux above 100 MeV from the analyzed Seyferts is {approx_equal} 4 Multiplication-Sign 10{sup -9} photons cm{sup -2} s{sup -1} , and the upper limits derived for several objects reach {approx_equal} 1 Multiplication-Sign 10{sup -9} photons cm{sup -2} s{sup -1} . Our results indicate that no prominent {gamma}-ray emission component related to active galactic nucleus activity is present in the spectra of Seyferts around GeV energies. The Fermi-LAT upper limits derived for our sample probe the ratio of {gamma}-ray to X-ray luminosities L{sub {gamma}}/L{sub X} < 0.1, and even <0.01 in some cases. The obtained results impose novel constraints on the models for high-energy radiation of 'radio-quiet' Seyfert galaxies.« less

From FERMI-LAT observations to the blind pulsar survey SPAN512 with the Nançay Radio Telescope

NASA Astrophysics Data System (ADS)

Octau, F.; Desvignes, G.; Cognard, I.; Champion, D.; Lazarus, P.; Smith, D.; Theureau, G.

2016-12-01

Since the discovery of the first pulsar in 1967, we know over 2500 pulsars today. Pulsars offer a broad range of studies: from the study of the properties of interstellar medium and of pulsar magnetospheres up to test of gravity in the strong-field regime and the characterisation of the cosmological Gravitation Wave Background. This explains why we keep searching for pulsars nowadays. Such focus was initiated at the Nançay Radio Telescope (NRT) with the observation of unidentified Fermi-LAT sources, which led to the quick discovery of three new millisecond pulsars. In 2012, a blind pulsar survey called SPAN512 (in reference to the large bandwidth of 512 MHz) was initiated and the NRT began to observe the low galactic latitude sky at 1.4 GHz. This survey is still in progress (≈90% of the observations have been made) and, up to now, it has led to the discovery of three pulsars, two of them with millisecond spin periods.

Probing the EBL Evolution at High Redshift Using GRBs Detected with the Fermi-LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Desai, A.; Ajello, M.; Omodei, N.

The extragalactic background light (EBL), from ultraviolet to infrared wavelengths, is predominantly due to emission from stars, accreting black holes and reprocessed light due to Galactic dust. The EBL can be studied through the imprint it leaves, via γ–γ absorption of high-energy photons, in the spectra of distant γ-ray sources. The EBL has been probed through the search for the attenuation it produces in the spectra of BL Lacertae (BL Lac) objects and individual γ-ray bursts (GRBs). GRBs have significant advantages over blazars for the study of the EBL especially at high redshifts. Here we analyze a combined sample ofmore » 22 GRBs, detected by the Fermi Large Area Telescope between 65 MeV and 500 GeV. We report a marginal detection (at the ~2.8σ level) of the EBL attenuation in the stacked spectra of the source sample. This measurement represents a first constraint of the EBL at an effective redshift of ~1.8. Here, we combine our results with prior EBL constraints and conclude that Fermi-LAT is instrumental to constrain the UV component of the EBL. We discuss the implications on existing empirical models of EBL evolution.« less

Probing the EBL Evolution at High Redshift Using GRBs Detected with the Fermi-LAT

DOE PAGES

Desai, A.; Ajello, M.; Omodei, N.; ...

2017-11-17

The extragalactic background light (EBL), from ultraviolet to infrared wavelengths, is predominantly due to emission from stars, accreting black holes and reprocessed light due to Galactic dust. The EBL can be studied through the imprint it leaves, via γ–γ absorption of high-energy photons, in the spectra of distant γ-ray sources. The EBL has been probed through the search for the attenuation it produces in the spectra of BL Lacertae (BL Lac) objects and individual γ-ray bursts (GRBs). GRBs have significant advantages over blazars for the study of the EBL especially at high redshifts. Here we analyze a combined sample ofmore » 22 GRBs, detected by the Fermi Large Area Telescope between 65 MeV and 500 GeV. We report a marginal detection (at the ~2.8σ level) of the EBL attenuation in the stacked spectra of the source sample. This measurement represents a first constraint of the EBL at an effective redshift of ~1.8. Here, we combine our results with prior EBL constraints and conclude that Fermi-LAT is instrumental to constrain the UV component of the EBL. We discuss the implications on existing empirical models of EBL evolution.« less

Fermi-LAT detection of increased gamma-ray activity from the FSRQ PKS 1004-217

NASA Astrophysics Data System (ADS)

Kreter, Michael

2018-03-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar (FSRQ) PKS 1004-217 (3FGL J1006.7-2159) with coordinates RA: 10h06m46.4136s, DEC: -21d59m20.410s, J2000 (Beasley et al. 2002, ApJS, 141, 13) and redshift z=0.331 (Hewitt & Burbidge 1989, ApJS, 69, 1). Preliminary analysis indicates that on 4 March 2018, this source was in a high-flux state with a daily averaged gamma-ray flux (E > 100MeV) of (0.84+/-0.08) X 10^-6 photons cm^-2 s^-1 (statistical uncertainties only).

Probing the gamma-ray emission from HESS J1834-087 using H.E.S.S. and Fermi LAT observations

NASA Astrophysics Data System (ADS)

H. E. S. S. Collaboration; Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; Akhperjanian, A. G.; Angüner, E.; Anton, G.; Backes, M.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Bissaldi, E.; Biteau, J.; Böttcher, M.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Chadwick, P. M.; Chalme-Calvet, R.; Chaves, R. C. G.; Cheesebrough, A.; Chrétien, M.; Colafrancesco, S.; Cologna, G.; Conrad, J.; Couturier, C.; Cui, Y.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; O'C. Drury, L.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Edwards, T.; Egberts, K.; Eger, P.; Espigat, P.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Giavitto, G.; Giebels, B.; Glicenstein, J. F.; Grondin, M.-H.; Grudzińska, M.; Häffner, S.; Hahn, J.; Harris, J.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hervet, O.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Janiak, M.; Jankowsky, F.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Kieffer, M.; Klepser, S.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Kolitzus, D.; Komin, Nu.; Kosack, K.; Krakau, S.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lefaucheur, J.; Lemière, A.; Lemoine-Goumard, M.; Lenain, J.-P.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Marx, R.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Méhault, J.; Meintjes, P. J.; Menzler, U.; Meyer, M.; Moderski, R.; Mohamed, M.; Moulin, E.; Murach, T.; Naumann, C. L.; de Naurois, M.; Niemiec, J.; Nolan, S. J.; Oakes, L.; Odaka, H.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, R. D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Poon, H.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raab, S.; Raue, M.; Reichardt, I.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Rob, L.; Romoli, C.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schüssler, F.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sol, H.; Spengler, G.; Spies, F.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Tavernet, J.-P.; Tavernier, T.; Taylor, A. M.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; van Soelen, B.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorster, M.; Vuillaume, T.; Wagner, S. J.; Wagner, P.; Wagner, R. M.; Ward, M.; Weidinger, M.; Weitzel, Q.; White, R.; Wierzcholska, A.; Willmann, P.; Wörnlein, A.; Wouters, D.; Yang, R.; Zabalza, V.; Zacharias, M.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

2015-02-01

Aims: Previous observations with the High Energy Stereoscopic System (H.E.S.S.) have revealed an extended very-high-energy (VHE; E> 100 GeV) γ-ray source, HESS J1834-087, coincident with the supernova remnant (SNR) W41. The origin of the γ-ray emission was investigated in more detail with the H.E.S.S. array and the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope. Methods: The γ-ray data provided by 61 h of observations with H.E.S.S., and four years with the Fermi LAT were analyzed, covering over five decades in energy from 1.8 GeV up to 30 TeV. The morphology and spectrum of the TeV and GeV sources were studied and multiwavelength data were used to investigate the origin of the γ-ray emission toward W41. Results: The TeV source can be modeled with a sum of two components: one point-like and one significantly extended (σTeV = 0.17° ± 0.01°), both centered on SNR W41 and exhibiting spectra described by a power law with index ΓTeV ≃ 2.6. The GeV source detected with Fermi LAT is extended (σGeV = 0.15° ± 0.03°) and morphologically matches the VHE emission. Its spectrum can be described by a power-law model with an index ΓGeV = 2.15 ± 0.12 and smoothly joins the spectrum of the whole TeV source. A break appears in the γ-ray spectra around 100 GeV. No pulsations were found in the GeV range. Conclusions: Two main scenarios are proposed to explain the observed emission: a pulsar wind nebula (PWN) or the interaction of SNR W41 with an associated molecular cloud. X-ray observations suggest the presence of a point-like source (a pulsar candidate) near the center of the remnant and nonthermal X-ray diffuse emission that could arise from the possibly associated PWN. The PWN scenario is supported by the compatible positions of the TeV and GeV sources with the putative pulsar. However, the spectral energy distribution from radio to γ-rays is reproduced by a one-zone leptonic model only if an excess of low-energy electrons is injected

The host galaxy and Fermi-LAT counterpart of HESS J1943+213

NASA Astrophysics Data System (ADS)

Peter, D.; Domainko, W.; Sanchez, D. A.; van der Wel, A.; Gässler, W.

2014-11-01

Context. The very-high energy (VHE, E> 100 GeV) gamma-ray sky shows diverse Galactic and extragalactic source populations. For some sources the astrophysical object class could not be identified so far. Aims: The nature (Galactic or extragalactic) of the VHE gamma-ray source HESS J1943+213 is explored. We specifically investigate the proposed near-infrared counterpart 2MASS J19435624+2118233 of HESS J1943+213 and investigate the implications of a physical association. Methods: We present K-band imaging from the 3.5 m CAHA telescope of 2MASS J19435624+2118233. Furthermore, 5 years of Fermi-LAT data were analyzed to search for a high-energy (HE, 100 MeV LAT a HE counterpart is found with a power-law spectrum above 1 GeV, with a normalization of (3.0 ± 0.8stat ± 0.6sys) × 10-15 cm-2 s-1 MeV-1 at the decorrelation energy Edec = 15.1 GeV and a spectral index of Γ = 1.59 ± 0.19stat ± 0.13sys. This gamma-ray spectrum shows a rather sharp break between the HE and VHE regimes of ΔΓ = 1.47 ± 0.36. Conclusions: The infrared and HE data strongly favor an extragalactic origin of HESS J1943+213, where the infrared counterpart traces the host galaxy of an extreme blazar and where the rather sharp spectral break between the HE and VHE regime indicates attenuation on extragalactic background light. The

Research and characterisation of blazar candidates among the Fermi/LAT 3FGL catalogue using multivariate classifications

NASA Astrophysics Data System (ADS)

Lefaucheur, Julien; Pita, Santiago

2017-06-01

Context. In the recently published 3FGL catalogue, the Fermi/LAT collaboration reports the detection of γ-ray emission from 3034 sources obtained after four years of observations. The nature of 1010 of those sources is unknown, whereas 2023 have well-identified counterparts in other wavelengths. Most of the associated sources are labelled as blazars (1717/2023), but the BL Lac or FSRQ nature of 573 of these blazars is still undetermined. Aims: The aim of this study was two-fold. First, to significantly increase the number of blazar candidates from a search among the large number of Fermi/LAT 3FGL unassociated sources (case A). Second, to determine the BL Lac or FSRQ nature of the blazar candidates, including those determined as such in this work and the blazar candidates of uncertain type (BCU) that are already present in the 3FGL catalogue (case B). Methods: For this purpose, multivariate classifiers - boosted decision trees and multilayer perceptron neural networks - were trained using samples of labelled sources with no caution flag from the 3FGL catalogue and carefully chosen discriminant parameters. The decisions of the classifiers were combined in order to obtain a high level of source identification along with well controlled numbers of expected false associations. Specifically for case A, dedicated classifications were generated for high (| b | >10◦) and low (| b | ≤10◦) galactic latitude sources; in addition, the application of classifiers to samples of sources with caution flag was considered separately, and specific performance metrics were estimated. Results: We obtained a sample of 595 blazar candidates (high and low galactic latitude) among the unassociated sources of the 3FGL catalogue. We also obtained a sample of 509 BL Lacs and 295 FSRQs from the blazar candidates cited above and the BCUs of the 3FGL catalogue. The number of expected false associations is given for different samples of candidates. It is, in particular, notably low ( 9

Discovery of Nine Gamma-Ray Pulsars in Fermi-Lat Data Using a New Blind Search Method

NASA Technical Reports Server (NTRS)

Celik-Tinmaz, Ozlem; Ferrara, E. C.; Pletsch, H. J.; Allen, B.; Aulbert, C.; Fehrmann, H.; Kramer, M.; Barr, E. D.; Champion, D. J.; Eatough, R. P.;

BL Lacertae Objects Beyond Redshift 1.3 - UV-to-NIR Photometry and Photometric Redshift for Fermi/LAT Blazars

NASA Technical Reports Server (NTRS)

Rau, A.; Schady, P.; Greiner, J.; Salvato, M.; Ajello, M.; Bottacini, E.; Gehrels, N.; Afonso, P. M. J.; Elliott, J.; Filgas, R.;

PSR J2030+364I: Radio Discovery and Gamma-ray Study of a Middle-aged Pulsar in the Now Identified Fermi-LAT Source 1FGL J2030.0+3641

NASA Technical Reports Server (NTRS)

Camilo, F.; Kerr, M.; Ray, P. S.; Ransom, S. M.; Johnston, S.; Romani, R. W.; Parent, D.; Decesar, M. E.; Harding, A. K.; Donato, D.;

Psr J2030+3641: Radio Discovery And Gamma-Ray Study Of A Middle-Aged Pulsar In The Now Identified Fermi -Lat Source 1FGL J2030.0+3641

DOE Office of Scientific and Technical Information (OSTI.GOV)

Camilo, F.; Kerr, M.; Ray, P. S.

2012-01-23

In a radio search with the Green Bank Telescope of three unidentified low Galactic latitude Fermi-LAT sources, we have discovered the middle-aged pulsar J2030+3641, associated with 1FGL J2030.0+3641 (2FGL J2030.0+3640). Following the detection of gamma-ray pulsations using a radio ephemeris, we have obtained a phase-coherent timing solution based on gamma-ray and radio pulse arrival times that spans the entire Fermi mission. With a rotation period of 0.2 s, spin-down luminosity of 3X10 34 erg s -1, and characteristic age of 0.5 Myr, PSR J2030+3641 is a middle-aged neutron star with spin parameters similar to those of the exceedingly gamma-ray-bright andmore » radio-undetected Geminga. Its gamma-ray flux is 1% that of Geminga, primarily because of its much larger distance, as suggested by the large integrated column density of free electrons, DM = 246 pc cm-3. We fit the gamma-ray light curve, along with limited radio polarimetric constraints, to four geometrical models of magnetospheric emission, and while none of the fits have high significance some are encouraging and suggest that further refinements of these models may be worthwhile. We argue that not many more non-millisecond radio pulsars may be detected along the Galactic plane that are responsible for LAT sources, but that modified methods to search for gamma-ray pulsations should be productive — PSR J2030+3641 would have been found blindly in gamma rays if only & 0:8 GeV photons had been considered, owing to its relatively flat spectrum and location in a region of high soft background.« less

Fermi LAT detection of a GeV flare from the FSRQ PKS 1004-217

NASA Astrophysics Data System (ADS)

Valverde, Janeth; Ojha, Roopesh

2017-11-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed an increasing gamma-ray flux from a source positionally consistent with the flat spectrum radio quasar (FSRQ) PKS 1004-217 with coordinates RA: 10h06m46.4136s, DEC: -21d59m20.410s, J2000 (Beasley et al. 2002, ApJS, 141, 13) and redshift z=0.330 (Browne & Savage, 1977, MNRAS, 179, 65). Preliminary analysis indicates that on 8 November 2017 and 9 November 2017, this source was in a high-flux state with a daily averaged gamma-ray flux (E > 100MeV) of (0.5+/-0.1) X 10^-6 photons cm^-2 s^-1 and (0.5+/-0.1) X 10^-6 photons cm^-2 s^-1, respectively (statistical uncertainties only).

50 CFR Table 5 (south) to Part 660... - 2009-2010 Trip Limits for Open Access Gears South of 40°10′ N. Lat.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2009-2010 Trip Limits for Open Access Gears South of 40°10ⲠN. Lat. 5 Table 5 (South) to Part 660, Subpart G Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Pt....

50 CFR Table 5 (north) to Part 660... - 2009-2010 Trip Limits for Open Access Gears North of 40°10′ N. Lat.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2009-2010 Trip Limits for Open Access Gears North of 40°10ⲠN. Lat. 5 Table 5 (North) to Part 660, Subpart G Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF WEST COAST STATES Pt....

Probing the gamma-ray emission from HESS J1834–087 using H.E.S.S. and FermiLAT observations

DOE PAGES

Abramowski, A.; Aharonian, F.; Ait Benkhali, F.; ...

2015-01-20

Aims. Previous observations with the High Energy Stereoscopic System (H.E.S.S.) have revealed an extended very-high-energy (VHE; E> 100 GeV) γ-ray source, HESS J1834-087, coincident with the supernova remnant (SNR) W41. The origin of the γ-ray emission was investigated in more detail with the H.E.S.S. array and the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope. Methods. For this research, the γ-ray data provided by 61 h of observations with H.E.S.S., and four years with the Fermi LAT were analyzed, covering over five decades in energy from 1.8 GeV up to 30 TeV. The morphology and spectrum of themore » TeV and GeV sources were studied and multiwavelength data were used to investigate the origin of the γ-ray emission toward W41. Results. The TeV source can be modeled with a sum of two components: one point-like and one significantly extended (σ TeV = 0.17° ± 0.01°), both centered on SNR W41 and exhibiting spectra described by a power law with index Γ TeV ≃ 2.6. The GeV source detected with Fermi LAT is extended (σ GeV = 0.15° ± 0.03°) and morphologically matches the VHE emission. Its spectrum can be described by a power-law model with an index Γ GeV = 2.15 ± 0.12 and smoothly joins the spectrum of the whole TeV source. A break appears in the γ-ray spectra around 100 GeV. No pulsations were found in the GeV range. Conclusions. Two main scenarios are proposed to explain the observed emission: a pulsar wind nebula (PWN) or the interaction of SNR W41 with an associated molecular cloud. X-ray observations suggest the presence of a point-like source (a pulsar candidate) near the center of the remnant and nonthermal X-ray diffuse emission that could arise from the possibly associated PWN. The PWN scenario is supported by the compatible positions of the TeV and GeV sources with the putative pulsar. However, the spectral energy distribution from radio to γ-rays is reproduced by a one-zone leptonic model only if an excess of low

Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia.

PubMed

Kim, Yong-Sik; Harry, G Jean; Kang, Hong Soon; Goulding, David; Wine, Rob N; Kissling, Grace E; Liao, Grace; Jetten, Anton M

2010-09-01

Previously, deficiency in the expression of the nuclear orphan receptor TAK1 was found to be associated with delayed cerebellar granule cell migration and Purkinje cell maturation with a permanent deficit in foliation of lobules VI–VII, suggesting a role for TAK1 in cerebellum development. In this study, we confirm that TAK1-deficient (TAK1(−/−)) mice have a smaller cerebellum and exhibit a disruption of lobules VI–VII. We extended these studies and show that at postnatal day 7, TAK1(−/−) mice exhibit a delay in monolayer maturation of dysmorphic calbindin 28K-positive Purkinje cells. The astrocyte-specific glutamate transporter (GLAST) was expressed within Bergmann fibers and internal granule cell layer at significantly lower levels in the cerebellum of TAK1(−/−) mice. At PND21, Golgi-positive Purkinje cells in TAK1(−/−) mice displayed a smaller soma (18%) and shorter distance to first branch point (35%). Neuronal death was not observed in TAK1(−/−) mice at PND21; however, activated microglia were present in the cerebellum, suggestive of earlier cell death. These structural deficits in the cerebellum were not sufficient to alter motor strength, coordination, or activity levels; however, deficits in acoustic startle response, prepulse startle inhibition, and social interactions were observed. Reactions to a novel environment were inhibited in a light/dark chamber, open-field, and home-cage running wheel. TAK1(−/−) mice displayed a plateau in performance on the running wheel, suggesting a deficit in learning to coordinate performance on a motor task. These data indicate that TAK1 is an important transcriptional modulator of cerebellar development and neurodevelopmentally regulated behavior.

Simultaneous long-term monitoring of LS I +61°303 by OVRO and Fermi-LAT

NASA Astrophysics Data System (ADS)

Jaron, Frédéric; Massi, Maria; Kiehlmann, Sebastian; Hovatta, Talvikki

2018-07-01

Previous long-term monitorings of the γ-ray-loud X-ray binary LS I +61°303 have revealed the presence of a long-term modulation of ˜4.5 yr. After 9 yr of simultaneous monitoring of LS I +61°303 by the Owens Valley Radio Observatory and the Fermi-LAT, two cycles of the long-term period are now available. Here we perform timing analysis on the radio and the γ-ray light curves. We confirm the presence of previously detected periodicities at both radio and GeV γ-ray wavelengths. Moreover, we discover an offset of the long-term modulation between radio and γ-ray data which could imply different locations of the radio (15 GHz) and GeV emission along the precessing jet.

['The spirit has left the bottle': the medieval Arabic physician 'Abd al-Latĭf ibn Yŭsuf al-Baghdădĭ: his medical work and his bizarre affiliation with twentieth-century spiritualism].

PubMed

Joosse, N Peter

2007-01-01

The Arabic physician 'Abd al-Latĭf ibn Yŭsuf al-Baghdădĭ, lived at the crossroads of the twelfth and the thirteenth century. His unbridled curiosity and his unquenchable thirst for knowledge of any kind brought him to far-away countries and regions and put him in contact with all sorts and conditions of people. The great Egyptian famine of the years 1200-1202 enabled him to study and examine thousands of human cadavers and skeletons at first hand. This led to a new understanding of the anatomical structure of the human body, and rejected the more or less antiquated ideas of the Greek doctor Galen of Pergamum. However, 'Abd al-Latĭf's vision was granted only a short life. After his death, his discovery sank into oblivion and as a consequence it was never again mentioned in Arabic medical manuals. From then on the Arabic physicians once more referred to the anatomical data which were developed and taught by Galen. Relatively few specimens of his remaining medical work were preserved for posterity. However, his Book of the two advices (or: K. al-Nasĭhatain) is of the utmost importance as a source for the medical thinking and the medical treatment in the late twelfth and the early thirteenth century A.D. During the years following World War I, 'Abd al-Latĭf's name reappeared within the spiritualistic movement in England. He became known as Abduhl Latif the great Persian physician and acted as a control of mediums. Until the late sixties, he practised the art of healing as the head of a medical mission somewhere in the Spheres.

Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter.

PubMed

Chianelli, M; Bizzarri, G; Todino, V; Misischi, I; Bianchini, A; Graziano, F; Guglielmi, R; Pacella, C M; Gharib, H; Papini, E

2014-07-01

It is normally recognized that the preferred treatment in large toxic thyroid nodules should be thyroidectomy. The aim of the study was to assess the efficacy of combined laser ablation treatment (LAT) and radioiodine 131 (131I) treatment of large thyroid toxic nodules with respect to rapidity of control of local symptoms, of hyperthyroidism, and of reduction of administered 131I activity in patients at refusal or with contraindications to surgery. We conducted a pilot study at a single center specializing in thyroid care. Fifteen patients were treated with LAT, followed by 131I (group A), and a series of matched consecutive patients were treated by 131I only (group B). Laser energy was delivered with an output power of 3 W (1800 J per fiber per treatment) through two 75-mm, 21-gauge spinal needles. Radioiodine activity was calculated to deliver 200 Gy to the hyperfunctioning nodule. Thyroid function, thyroid peroxidase antibody, thyroglobulin antibody, ultrasound, and local symptoms were measured at baseline and up to 24 months. Nodule volume reduction at 24 months was: 71.3 ± 13.4 vs 47.4 ± 5.5%, group A (LAT+131I) vs group B (131I), respectively; P < .001). In group A (LAT+131I), a reduction in radioiodine-administered activity was obtained (-21.1 ± 8.1%). Local symptom score demonstrated a more rapid reduction in group A (LAT+131I). In three cases, no 131I treatment was needed after LAT. In this pilot study, combined LAT/131I treatment induced faster and greater improvement of local and systemic symptoms compared to 131I only. This approach seems a possible alternative to thyroidectomy in patients at refusal of surgery.

The Origins of the Gamma-Ray Flux Variations of NGC 1275 Based on Eight Years of Fermi-LAT Observations

NASA Astrophysics Data System (ADS)

Tanada, K.; Kataoka, J.; Arimoto, M.; Akita, M.; Cheung, C. C.; Digel, S. W.; Fukazawa, Y.

2018-06-01

We present an analysis of eight years of Fermi-LAT (>0.1 GeV) γ-ray data obtained for the radio galaxy NGC 1275. The γ-ray flux from NGC 1275 is highly variable on short (∼days to weeks) timescales, and has steadily increased over this eight year timespan. By examining the changes in its flux and spectral shape in the LAT energy band over the entire data set, we found that its spectral behavior changed around 2011 February (∼MJD 55600). The γ-ray spectra at early times evolved largely at high energies, while the photon indices were unchanged at later times despite rather large flux variations. To explain these observations, we suggest that the flux changes at the early times were caused by injection of high-energy electrons into the jet while, later, the γ-ray flares were caused by a changing Doppler factor owing to variations in the jet Lorentz factor and/or changes in the angle to our line of sight. To demonstrate the viability of these scenarios, we fit the broad band spectral energy distribution data with a one-zone synchrotron self-Compton (SSC) model for flaring and quiescent intervals before and after 2011 February. To explain the γ-ray spectral behavior in the context of the SSC model, the maximum electron Lorentz factor would have changed at the early times, while a modest change in the Doppler factor adequately fits the quiescent and flaring state γ-ray spectra at the later times.

YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells is Regulated by LCK and Independent of LATS Activity.

PubMed

Sugihara, Takaaki; Werneburg, Nathan W; Hernandez, Matthew C; Yang, Lin; Kabashima, Ayano; Hirsova, Petra; Yohanathan, Lavanya; Sosa, Carlos; Truty, Mark Joseph; Vasmatzis, George; Gores, Gregory J; Smoot, Rory L

2018-06-14

The hippo pathway effector, Yes-associated protein (YAP) is a transcriptional co-activator implicated in cholangiocarcinoma (CCA) pathogenesis. YAP is known to be regulated by a serine/threonine kinase relay module (MST1/2 - LATS1/2) culminating in phosphorylation of YAP at Serine 127 (S127) and cytoplasmic sequestration. However, YAP also undergoes tyrosine phosphorylation, and the role of tyrosine phosphorylation in YAP regulation remains unclear. Herein, YAP regulation by tyrosine phosphorylation was examined in human and mouse CCA cells, as well as patient-derived xenograft (PDX) models. YAP was phosphorylated on tyrosine 357 (Y357) in CCA cell lines and PDX models. SRC family kinase (SFK) inhibition with dasatinib resulted in loss of YAPY357 phosphorylation, promoted its translocation from the nucleus to the cytoplasm, and reduced YAP target gene expression; including cell lines expressing a LATS1/2-resistant YAP mutant in which all serine residues were mutated to alanine. Consistent with these observations, precluding YAPY357 phosphorylation by site-directed mutagenesis (YAPY357F) excluded YAP from the nucleus. Targeted siRNA experiments identified LCK as the SFK that most potently mediated YAPY357 phosphorylation. Likewise, inducible CRISPR/Cas9-targeted LCK deletion decreased YAPY357 phosphorylation and its nuclear localization. The importance of LCK in CCA biology was demonstrated by clinical observations suggesting LCK expression levels were associated with early tumor recurrence following resection of CCA. Finally, dasatinib displayed therapeutic efficacy in PDX models. Demonstration of targetable, LCK-mediated YAP tyrosine phosphorylation in CCA regulating YAP's nuclear retention and oncogenic activity. Copyright ©2018, American Association for Cancer Research.

A COTS-Based Attitude Dependent Contact Scheduling System

NASA Technical Reports Server (NTRS)

DeGumbia, Jonathan D.; Stezelberger, Shane T.; Woodard, Mark

2006-01-01

The mission architecture of the Gamma-ray Large Area Space Telescope (GLAST) requires a sophisticated ground system component for scheduling the downlink of science data. Contacts between the ````````````````` satellite and the Tracking and Data Relay Satellite System (TDRSS) are restricted by the limited field-of-view of the science data downlink antenna. In addition, contacts must be scheduled when permitted by the satellite s complex and non-repeating attitude profile. Complicating the matter further, the long lead-time required to schedule TDRSS services, combined with the short duration of the downlink contact opportunities, mandates accurate GLAST orbit and attitude modeling. These circumstances require the development of a scheduling system that is capable of predictively and accurately modeling not only the orbital position of GLAST but also its attitude. This paper details the methods used in the design of a Commercial Off The Shelf (COTS)-based attitude-dependent. TDRSS contact Scheduling system that meets the unique scheduling requirements of the GLAST mission, and it suggests a COTS-based scheduling approach to support future missions. The scheduling system applies filtering and smoothing algorithms to telemetered GPS data to produce high-accuracy predictive GLAST orbit ephemerides. Next, bus pointing commands from the GLAST Science Support Center are used to model the complexities of the two dynamic science gathering attitude modes. Attitude-dependent view periods are then generated between GLAST and each of the supporting TDRSs. Numerous scheduling constraints are then applied to account for various mission specific resource limitations. Next, an optimization engine is used to produce an optimized TDRSS contact schedule request which is sent to TDRSS scheduling for confirmation. Lastly, the confirmed TDRSS contact schedule is rectified with an updated ephemeris and adjusted bus pointing commands to produce a final science downlink contact schedule.

Fermi LAT Detection of a GeV Flare from the Radio-Loud Narrow-Line Sy1 1H 0323+342

NASA Astrophysics Data System (ADS)

Carpenter, Bryce; Ojha, Roopesh

2013-08-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with 1H 0323+342 (RA=03h24m41.1613s, Dec=+34d10m45.856s, J2000; Beasley et al. 2002, ApJS, 141, 13) at z= 0.061 (Marcha et al. 1996, MNRAS, 281, 425). This is the second nearest radio-loud Narrow-Line Seyfert 1 galaxy, a small and important class of gamma-ray loud AGN (Abdo et al.

Role of Transmembrane Domain 8 in Substrate Selectivity and Translocation of SteT, a Member of the l-Amino Acid Transporter (LAT) Family*

PubMed Central

Bartoccioni, Paola; del Rio, César; Ratera, Merce; Kowalczyk, Lukasz; Baldwin, Jocelyn M.; Zorzano, Antonio; Quick, Matthias; Baldwin, Stephen A.; Vázquez-Ibar, José Luis; Palacín, Manuel

2010-01-01

System l-amino acid transporters (LAT) belong to the amino acid, polyamine, and organic cation superfamily of transporters and include the light subunits of heteromeric amino acid transporters and prokaryotic homologues. Cysteine reactivity of SteT (serine/threonine antiporter) has been used here to study the substrate-binding site of LAT transporters. Residue Cys-291, in transmembrane domain 8 (TM8), is inactivated by thiol reagents in a substrate protectable manner. Surprisingly, DTT activated the transporter by reducing residue Cys-291. Cysteine-scanning mutagenesis of TM8 showed DTT activation in the single-cysteine mutants S287C, G294C, and S298C, lining the same α-helical face. S-Thiolation in Escherichia coli cells resulted in complete inactivation of the single-cysteine mutant G294C. l-Serine blocked DTT activation with an EC50 similar to the apparent KM of this mutant. Thus, S-thiolation abolished substrate translocation but not substrate binding. Mutation of Lys-295, to Cys (K295C) broadened the profile of inhibitors and the spectrum of substrates with the exception of imino acids. A structural model of SteT based on the structural homologue AdiC (arginine/agmatine antiporter) positions residues Cys-291 and Lys-295 in the putative substrate binding pocket. All this suggests that Lys-295 is a main determinant in the recognition of the side chain of SteT substrates. In contrast, Gly-294 is not facing the surface, suggesting conformational changes involving TM8 during the transport cycle. Our results suggest that TM8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT. PMID:20610400

Fermi LAT detection of gamma-ray flaring activity from the blazar MG J221916+1806 through the Fermi All-sky Variability Analysis (FAVA)

NASA Astrophysics Data System (ADS)

Ajello, M.; Kocevski, D.; Gasparrini, D.; Buehler, R.; Thompson, D.; Ciprini, S.

2014-03-01

During the week between March 17 and March 24, 2014, the Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increased gamma-ray activity from a source positionally coincident with the flat-spectrum radio quasar MG J221916+1806 (also known as 2FGL J2219.1+1805, Nolan et al., 2012, ApJS, 199, 31, and CGRaBS J2219+1806, Healey et al. ...

Fermi LAT detection of renewed and strong GeV gamma-ray flares from blazars PKS 0903-57 and PKS 0346-27

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2018-05-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed high-level gamma-ray activity from sources positionally consistent with the active galaxy PKS 0903-57 (also known as MRC 0903-573 and 3FGL J0904.8-5734, Acero et al. 2015, ApJS, 218, 23) and with the flat spectrum radio quasar PKS 0346-27 (also known as OE -278, TXS 0346-279, MRC 0346-279 and 3FGL J0348.6-2748).

Fermi-LAT high-z active galactic nuclei and the extragalactic background light

NASA Astrophysics Data System (ADS)

Armstrong, Thomas; Brown, Anthony M.; Chadwick, Paula M.

2017-10-01

Observations of distant gamma-ray sources are hindered by the presence of the extragalactic background light (EBL). In order to understand the physical processes that result in the observed spectrum of sources, it is imperative that a good understanding of the EBL is included. In this work, an investigation into the imprint of the EBL on the observed spectra of high-redshift Fermi-LAT active galactic nuclei is presented. By fitting the spectrum below ˜10 GeV, an estimation of the unabsorbed intrinsic source spectrum is obtained; by applying this spectrum to data up to 300 GeV, it is then possible to derive a scaling factor for different EBL models. A second approach uses five sources (PKS 0426-380, 4C +55.17, Ton 116, PG 1246+586 and RBS 1432) that were found to exhibit very high energy (VHE) emission (Eγ > 100 GeV). Through Monte Carlo simulations, it is shown that the observation of VHE photons, despite the large distances of these objects, is consistent with current EBL models. Many of these sources would be observable with the upcoming ground-based observatory, the Cherenkov Telescope Array, leading to a better understanding of the EBL.

Search for γ-ray emission from superluminous supernovae with the Fermi-LAT

NASA Astrophysics Data System (ADS)

Renault-Tinacci, N.; Kotera, K.; Neronov, A.; Ando, S.

2018-03-01

We present the first individual and stacking systematic search for γ-ray emission in the GeV band in the directions of 45 superluminous supernovae (SLSNe) with the Fermi Large Area Telescope (LAT). No excess of γ-rays from the SLSN positions was found. We report γ-ray luminosity upper limits and discuss the implication of these results on the origin of SLSNe and, in particular, the scenario of central compact object-aided SNe. From the stacking search, we derived an upper limit at 95% confidence level to the γ-ray luminosity (above 600 MeV) Lγ < 9.1 × 1041 erg s-1 for an assumed E-2 photon spectrum for our full SLSN sample. We conclude that the rate of the neutron stars born with millisecond rotation periods P ≲ 2 ms and B 1012-13 G must be lower than the rate of the observed SLSNe. The luminosity limits obtained on individual sources are also constraining: in particular, SN2013fc, CSS140222, SN2010kd, and PTF12dam can only be born with millisecond periods if B ≲ 1013 G.

Implications of Fermi-LAT observations on the origin of IceCube neutrinos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Bin; Li, Zhuo; Zhao, Xiaohong, E-mail: wang_b@pku.edu.cn, E-mail: zhaoxh@ynao.ac.cn, E-mail: zhuo.li@pku.edu.cn

2014-11-01

The IceCube (IC) collaboration recently reported the detection of TeV-PeV extraterrestrial neutrinos whose origin is yet unknown. By the photon-neutrino connection in pp and pγ interactions, we use the Fermi-LAT observations to constrain the origin of the IC detected neutrinos. We find that Galactic origins, i.e., the diffuse Galactic neutrinos due to cosmic ray (CR) propagation in the Milky Way, and the neutrinos from the Galactic point sources, may not produce the IC neutrino flux, thus these neutrinos should be of extragalactic origin. Moreover, the extragalactic gamma-ray bursts (GRBs) may not account for the IC neutrino flux, the jets ofmore » active galactic nuclei may not produce the IC neutrino spectrum, but the starburst galaxies (SBGs) may be promising sources. As suggested by the consistency between the IC detected neutrino flux and the Waxman-Bahcall bound, GRBs in SBGs may be the sources of both the ultrahigh energy, ∼> 10{sup 19}eV, CRs and the 1–100 PeV CRs that produce the IC detected TeV-PeV neutrinos.« less

50 CFR Table 3 (south) to Part 660... - Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears South of 40°10′ N. Lat.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears South of 40°10ⲠN. Lat. 3 Table 3 (South) to Part 660, Subpart F Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

50 CFR Table 3 (north) to Part 660... - Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears North of 40°10′ N. Lat.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears North of 40°10ⲠN. Lat. 3 Table 3 (North) to Part 660, Subpart F Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION...

Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism

PubMed Central

Hamdi, M M; Mutungi, G

2011-01-01

Abstract Dihydrotestosterone (DHT) has acute/non-genomic actions in adult mammalian skeletal muscles whose physiological functions are still poorly understood. Therefore, the primary aim of this study was to investigate the acute/non-genomic effects of DHT on amino acid uptake as well as the cellular signal transduction events underlying these actions in mouse fast- and slow-twitch skeletal muscle fibre bundles. 14C-Labelled amino acids were used to investigate the effects of DHT and testosterone (T) on amino acid uptake and pharmacological interventions were used to determine the cellular signal transduction events mediating these actions. While T had no effect on the uptake of isoleucine (Ile) and α-methylaminoisobutyric acid (MeAIB) in both fibre types, DHT increased their uptake in the fast-twitch fibre bundles. This effect was reversed by inhibitors of protein translation, the epidermal growth factor receptor (EGFR), system A, system L, mTOR and MEK. However, it was relatively insensitive to inhibitors of transcription, androgen receptors and PI3K/Akt. Additionally, DHT treatment increased the expression of LAT2 and the phosphorylation of the EGFR in the fast-twitch fibre bundles and that of ERK1/2, RSK1/2 and ATF2 in both fibre types. Also, it decreased the phosphorylation of eEF2 and increased the incorporation of Ile into proteins in both fibre types. Most of these effects were reversed by EGFR and MEK inhibitors. From these findings we suggest that another physiological function of the acute/non-genomic actions of DHT in isolated mammalian skeletal muscle fibres is to stimulate amino acid uptake. This effect is mediated through the EGFR and involves the activation of the MAPK pathway and an increase in LAT2 expression. PMID:21606113

Multicenter, Randomized, Controlled Study Comparing Tafluprost/Timolol Fixed Combination with Latanoprost/Timolol Fixed Combination in Primary Open-Angle Glaucoma and Ocular Hypertension.

PubMed

Suzuki, Katsuyoshi; Otsuka, Naomi; Hizaki, Hiroko; Hashimoto, Masayo; Kuwayama, Yasuaki

2018-06-05

This was the first exploratory randomized controlled study to compare the efficacy and safety of a preserved tafluprost/timolol fixed combination (TAF/TIM) with a preserved latanoprost/timolol fixed combination (LAT/TIM). This prospective, randomized, open-label study was conducted in Japanese patients with primary open-angle glaucoma, including normal-tension glaucoma or ocular hypertension. Following a 4-week LAT/TIM run-in period, eligible patients entered a 12-week treatment period, during which they received either LAT/TIM or TAF/TIM. The efficacy endpoint was the change in intraocular pressure (IOP) from baseline to week 12 and the safety endpoints included the changes from baseline to week 12 in superficial punctate keratopathy (SPK) score, tear breakup time (TBUT), and hyperemia score, as well as adverse events (AEs). At week 6, ocular symptoms were evaluated using a questionnaire. In total, 131 patients provided informed consent. Of these, 115 completed the run-in period and were assigned to receive TAF/TIM (n = 60) or LAT/TIM (n = 55). At week 12, there were no significant differences between the TAF/TIM and LAT/TIM groups in the change from baseline in trough IOP and IOP at 4-6 h after instillation. There were no significant differences between the two groups in the change from baseline to week 12 in SPK score, TBUT, and hyperemia score. However, only in the TAF/TIM group, the total SPK score and the inferior cornea SPK score were significantly lower at week 12 compared with baseline. Eye irritation and eye pain were significantly decreased in the TAF/TIM group compared with the LAT/TIM group. Two treatment-related AEs were reported in the TAF/TIM group (3.3%) and none in the LAT/TIM group, while no serious AEs were reported in either group. TAF/TIM is as effective as LAT/TIM in terms of IOP-reducing effect, with fewer ocular symptoms. TAF/TIM was associated with a significant improvement in SPK scores. UMIN Clinical Trials Registry Identifier

Leaked GeV CRs from a Broken Shell: Explaining 9 Years of Fermi-LAT Data of SNR W28

NASA Astrophysics Data System (ADS)

Cui, Yudong; Yeung, Paul K. H.; Tam, P. H. Thomas; Pühlhofer, Gerd

2018-06-01

Supernova remnant (SNR)W28 is well known for its classic hadronic scenario, in which the TeV cosmic rays (CRs) released at the early stage of this intermediate-age SNR illuminate nearby molecular clouds (MCs). Overwhelming evidence has shown that the northeastern part of the SNR (W28-North) has already encountered the MC clumps. Through this broken shell W28-North, CRs with an energy down to <1 GeV may be able to be injected into nearby MCs. To further verify this hadronic scenario, we first analyze nine years of Fermi-LAT data in/around W28 with energies down to 0.3 GeV. Our Fermi-LAT analysis displays a 10–200 GeV skymap that spatially matches the known TeV sources HESS J1801–233 (W28-North) and HESS J1800–240 A, B, and C (240 A B and C) well. At low energy bands, we have discovered a 0.5–1 GeV blob located to the south of 240 B and C, and a low flux of 0.3–1 GeV at 240 A. A hadronic model is build to explain our analysis results and previous multiwavelength observations of W28. Our model consists of three CR sources: the run-away CRs escaped from a strong shock, the leaked GeV CRs from the broken shell W28-North, and the local CR sea. Through modeling the SNR evolution and the CR acceleration and release, we explain the GeV–TeV emission in/around SNR W28 (except for 240 A) in one model. The damping of the magnetic waves by the neutrals and the decreased acceleration efficiency are both taken into account in our model due to the intermediate age of SNR W28.

Fermi LAT detection of renewed GeV gamma-ray activity from the gravitationally lensed blazar PKS 1830-211

NASA Astrophysics Data System (ADS)

Ciprini, Stefano

2012-06-01

The Large Area Telescope (LAT), one of the two instruments on the Fermi Gamma-ray Space Telescope, has observed increasing gamma-ray flux from a source positionally consistent with PKS 1830-211 (also known as 2FGL J1833.6-2104, Nolan et al. 2012, ApJS, 199, 31, placed at RA: 18h 33m 39.9s, Dec -21d 03m 40s, J2000, van Ommen et al., 1995, ApJ, 444, 561). PKS 1830-211 (z=2.507, Lovell et al. 1998, ApJ, 508, L51) is a distant and peculiar flat spectrum radio quasar with intervening absorption systems and being subject to gravitational lensing by a galaxy placed at z=0.886 (Wiklind & Combes 1996, Nature, 379, 11).

Studies on the seasonal variation of atmospheric electricity parameters at a tropical station in Kolkata, India

NASA Astrophysics Data System (ADS)

De, S. S.; Paul, Suman; Barui, S.; Pal, Pinaki; Bandyopadhyay, B.; Kala, D.; Ghosh, A.

2013-12-01

The paper deals with the analyses of the atmospheric vertical potential gradient (PG) from the ground for 90 fair weather days during 2006-2009 measured at Kolkata (Lat: 22.56°N). The variations of PG have been studied extensively to investigate their values during monsoon and winter seasons. Higher values of PG at Kolkata are observed due to higher abundance of pollutant particles. The observed PG are compared with the results of Potsdam station (Lat: 52°N) and Johannesburg station (Lat: 26°S), with 9 years data and 2 years data respectively. The correlations studies are carried out among PG, PDC (Point Discharge Current) as well as negative and positive carrier conductivities. The corresponding correlation coefficients are obtained as 0.93, -0.842 and -0.844.

Simulation of Cosmic Ray Acceleration, Propagation and Interaction in SNR Environment

NASA Astrophysics Data System (ADS)

Lee, S. H.; Kamae, T.; Ellison, D. C.

2007-07-01

Recent studies of young supernova remnants (SNRs) with Chandra, XMM, Suzaku and HESS have revealed complex morphologies and spectral features of the emission sites. The critical question of the relative importance of the two competing gamma-ray emission mechanisms in SNRs; inverse-Compton scattering by high-energy electrons and pion production by energetic protons, may be resolved by GLAST-LAT. To keep pace with the improved observations, we are developing a 3D model of particle acceleration, diffusion, and interaction in a SNR where broad-band emission from radio to multi-TeV energies, produced by shock accelerated electrons and ions, can be simulated for a given topology of shock fronts, magnetic field, and ISM densities. The 3D model takes as input, the particle spectra predicted by a hydrodynamic simulation of SNR evolution where nonlinear diffusive shock acceleration is coupled to the remnant dynamics (e.g., Ellison, Decourchelle & Ballet; Ellison & Cassam-Chenai Ellison, Berezhko & Baring). We will present preliminary models of the Galactic Ridge SNR RX J1713-3946 for selected choices of SNR parameters, magnetic field topology, and ISM density distributions. When constrained by broad-band observations, our models should predict the extent of coupling between spectral shape and morphology and provide direct information on the acceleration efficiency of cosmic-ray electrons and ions in SNRs.

50 CFR Table 3 (north) to Part 660... - Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears North of 40°10′ N. Lat.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears North of 40°10â² N. Lat. 3 Table 3 (North) to Part 660, Subpart F...) to Part 660, Subpart F—Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears...

50 CFR Table 3 (south) to Part 660... - Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears South of 40°10′ N. Lat.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears South of 40°10â² N. Lat. 3 Table 3 (South) to Part 660, Subpart F...) to Part 660, Subpart F—Non-Trawl Rockfish Conservation Areas and Trip Limits for Open Access Gears...

KSC-08pd0762

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, a General Dynamics technician studies one of twin solar arrays that will be installed on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

Hunting dark matter gamma-ray lines with the Fermi LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vertongen, Gilles; Weniger, Christoph, E-mail: gilles.vertongen@desy.de, E-mail: weniger@mppmu.mpg.de

2011-05-01

Monochromatic photons could be produced in the annihilation or decay of dark matter particles. At high energies, the search for such line features in the cosmic gamma-ray spectrum is essentially background free because plausible astrophysical processes are not expected to produce such a signal. The observation of a gamma-ray line would hence be a 'smoking-gun' signature for dark matter, making the search for such signals particularly attractive. Among the different dark matter models predicting gamma-ray lines, the local supersymmetric extension of the standard model with small R-parity violation and gravitino LSP is of particular interest because it provides a frameworkmore » where primordial nucleosynthesis, gravitino dark matter and thermal leptogenesis are naturally consistent. Using the two-years Fermi LAT data, we present a dedicated search for gamma-ray lines coming from dark matter annihilation or decay in the Galactic halo. Taking into account the full detector response, and using a binned profile likelihood method, we search for significant line features in the energy spectrum of the diffuse flux observed in different regions of the sky. No evidence for a line signal at the 5σ level is found for photon energies between 1 and 300 GeV, and conservative bounds on dark matter decay rates and annihilation cross sections are presented. Implications for gravitino dark matter in presence of small R-parity violation are discussed, as well as the impact of our results on the prospect for seeing long-lived neutralinos or staus at the LHC.« less

HESS and Fermi-LAT discovery of γ-rays from the blazar 1ES 1312-423

DOE PAGES

Abramowski, A.; Acero, F.; Aharonian, F.; ...

2013-08-01

In this study, a deep observation campaign carried out by the High Energy Stereoscopic System (HESS) on Centaurus A enabled the discovery of γ-rays from the blazar 1ES 1312-423, 2° away from the radio galaxy. With a differential flux at 1 TeV of (Φ1 TeV) = (1.9 ± 0.6stat ± 0.4sys) × 10 -13 cm -2 s -1 TeV -1 corresponding to 0.5 percent of the Crab nebula differential flux and a spectral index Γ = 2.9 ± 0.5stat ± 0.2sys, 1ES 1312-423 is one of the faintest sources ever detected in the very high energy (E > 100 GeV)more » extragalactic sky. A careful analysis using three and a half years of Fermi Large Area Telescope (Fermi-LAT) data allows the discovery at high energies (E > 100 MeV) of a hard spectrum (Γ = 1.4 ± 0.4stat ± 0.2sys) source coincident with 1ES 1312-423. Radio, optical, UV and X-ray observations complete the spectral energy distribution of this blazar, now covering 16 decades in energy. Lastly, the emission is successfully fitted with a synchrotron self-Compton model for the non-thermal component, combined with a blackbody spectrum for the optical emission from the host galaxy.« less

KSC-08pd0764

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians guide one of twin solar arrays toward NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0783

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, the mechanism on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, solar arrays has been released. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0784

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, completes the test of the deployment mechanism on its solar arrays. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0761

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians prepare to install the twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0765

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, one of twin solar arrays is positioned on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0770

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians install the second of twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0769

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians move the second of twin solar arrays toward NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0766

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians install one of twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

Search for gamma-ray emission from the nearby dwarf spheroidal galaxies with 9 years of Fermi-LAT data

NASA Astrophysics Data System (ADS)

Li, Shang; Duan, Kai-Kai; Liang, Yun-Feng; Xia, Zi-Qing; Shen, Zhao-Qiang; Li, Xiang; Liao, Neng-Hui; Feng, Lei; Yuan, Qiang; Fan, Yi-Zhong; Chang, Jin

2018-06-01

In this work, we search for γ -ray emission from nearby Milky Way dwarf spheroidal galaxies (dSphs) and candidates with the publicly available Pass 8 data of Fermi-LAT. Our sample includes 12 sources with the distances <50 kpc . Very weak γ -ray excesses (˜2 σ ) are found in some dSphs/candidates, consistent with those reported in the previous literature. Intriguingly, the peak test statistic (TS) value of the weak emission from Reticulum II rises continually. If interpreted as dark matter (DM) annihilation, the peak TS value is 13.5 for the annihilation channel of χ χ →τ+τ- and the DM mass of mχ˜16 GeV . The combination of all these nearby sources yields a more significant (with local significance >4 σ ) γ -ray signal.

A Study of Fermi-LAT GeV γ-Ray Emission toward the Magnetar-harboring Supernova Remnant Kesteven 73 and Its Molecular Environment

NASA Astrophysics Data System (ADS)

Liu, Bing; Chen, Yang; Zhang, Xiao; Liu, Qian-Cheng; He, Ting-Lan; Zhou, Xin; Zhou, Ping; Su, Yang

2017-12-01

We report our independent GeV γ-ray study of the young shell-type supernova remnant (SNR) Kes 73, which harbors a central magnetar, and CO-line millimeter observations toward the SNR. Using 7.6 years of Fermi-LAT observation data, we detected an extended γ-ray source (“source A”) with centroid on the west of the SNR, with a significance of 21σ in 0.1-300 GeV and an error circle of 5.‧4 in angular radius. The γ-ray spectrum cannot be reproduced by a pure leptonic emission or a pure emission from the magnetar, and thus a hadronic emission component is needed. The CO-line observations reveal a molecular cloud (MC) at V LSR ˜ 90 km s-1, which demonstrates morphological correspondence with the western boundary of the SNR brightened in multiwavelength. The 12CO (J = 2 - 1)/12CO (J = 1 - 0) ratio in the left (blue) wing 85-88 km s-1 is prominently elevated to ˜1.1 along the northwestern boundary, providing kinematic evidence of the SNR-MC interaction. This SNR-MC association yields a kinematic distance 9 kpc to Kes 73. The MC is shown to be capable of accounting for the hadronic γ-ray emission component. The γ-ray spectrum can be interpreted with a pure hadronic emission or a magnetar+hadronic hybrid emission. In the case of pure hadronic emission, the spectral index of the protons is 2.4, very similar to that of the radio-emitting electrons, essentially consistent with the diffusive shock acceleration theory. In the case of magnetar+hadronic hybrid emission, a magnetic field decay rate ≳1036 erg s-1 is needed to power the magnetar’s curvature radiation.

Active Galaxies Educational Unit: An Educator's Guide with Activities in Science and Mathematics.

ERIC Educational Resources Information Center

National Aeronautics and Space Administration, Washington, DC.

As a part of its educational effort, the National Aeronautics and Space Administration (NASA) Education and Public Outreach group at Sonoma State University (SSU) has put together a series of activities based on the science of one of NASA's exciting space missions, the Gamma-ray Large Area Space Telescope (GLAST). GLAST is a NASA satellite planned…

Five New Millisecond Pulsars from a Radio Survey of 14 Unidentified Fermi-LAT Gamma-Ray Sources

NASA Technical Reports Server (NTRS)

Kerr, M.; Camilo, F.; Johnson, T. J.; Ferrara, E. C.; Guillemot, L.; Harding, A. K.; Hessels, J.; Johnson, S.; Keith, M.; Kramer, M.;

Extended Higgs-portal dark matter and the Fermi-LAT Galactic Center Excess

NASA Astrophysics Data System (ADS)

Casas, J. A.; Gómez Vargas, G. A.; Moreno, J. M.; Quilis, J.; Ruiz de Austri, R.

2018-06-01

In the present work, we show that the Galactic Center Excess (GCE) emission, as recently updated by the Fermi-LAT Collaboration, could be explained by a mixture of Fermi-bubbles-like emission plus dark matter (DM) annihilation, in the context of a scalar-singlet Higgs portal scenario (SHP). In fact, the standard SHP, where the DM particle, S, only has renormalizable interactions with the Higgs, is non-operational due to strong constraints, especially from DM direct detection limits. Thus we consider the most economical extension, called ESHP (for extended SHP), which consists solely in the addition of a second (more massive) scalar singlet in the dark sector. The second scalar can be integrated-out, leaving a standard SHP plus a dimension-6 operator. Mainly, this model has only two relevant parameters (the DM mass and the coupling of the dim-6 operator). DM annihilation occurs mainly into two Higgs bosons, SS→ hh. We demonstrate that, despite its economy, the ESHP model provides an excellent fit to the GCE (with p-value ~ 0.6‑0.7) for very reasonable values of the parameters, in particular, mS simeq 130 GeV. This agreement of the DM candidate to the GCE properties does not clash with other observables and keep the S‑particle relic density at the accepted value for the DM content in the universe.

Direct constraints on minimal supersymmetry from Fermi-LAT observations of the dwarf galaxy Segue 1

DOE PAGES

Scott, Pat; Conrad, Jan; Edsjö, Joakim; ...

2010-01-26

The dwarf galaxy Segue 1 is one of the most promising targets for the indirect detection of dark matter. We examine what constraints 9 months of Fermi-LAT gamma-ray observations of Segue 1 place upon the Constrained Minimal Supersymmetric Standard Model (CMSSM), with the lightest neutralino as the dark matter particle. We also use nested sampling to explore the CMSSM parameter space, simultaneously fitting other relevant constraints from accelerator bounds, the relic density, electroweak precision observables, the anomalous magnetic moment of the muon and B-physics. We include spectral and spatial fits to the Fermi observations, a full treatment of the instrumentalmore » response and its related uncertainty, and detailed background models. We also perform an extrapolation to 5 years of observations, assuming no signal is observed from Segue 1 in that time. Our results marginally disfavour models with low neutralino masses and high annihilation cross-sections. Virtually all of these models are however already disfavoured by existing experimental or relic density constraints.« less

X-ray Follow-ups of XSS J12270-4859: A Low-mass X-ray Binary with Gamma-ray Fermi-LAT Association

NASA Technical Reports Server (NTRS)

deMartino, D.; Belloni, T.; Falanga, M.; Papitto, A.; Motta, S.; Pellizzoni, A.; Evangelista, Y.; Piano, G.; Masetti, N.; Mouchet, M.;

KSC-08pd1135

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians stretch protective cover over NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. GLAST is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1136

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians stretch protective cover over NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. GLAST is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1419

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers prepare to move the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1425

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, the GLAST spacecraft is lowered onto the Delta II second stage in the mobile service tower. GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1421

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers help maneuver the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1359

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians lower NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft toward the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1358

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians lower NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft toward the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

Fermi LAT Detection of a GeV Gamma-Ray Flare from the Be-Pulsar Binary System PSR B1259-63 with Rapid Variability

NASA Astrophysics Data System (ADS)

Johnson, T. J.; Wood, K. S.; Ray, P. S.; Ferrara, E. C.; Kerr, M. T.; Cheung, C. C.

2017-11-01

Using data from the Large Area Telescope (LAT), one of the two instruments on board the Fermi Gamma-ray Space Telescope, we have detected a > 100 MeV flare from PSR B1259-63 over the time interval 2017-11-02 01:47:25 UTC to 2017-11-03 06:29:13 UTC with a significance of approximately 10 sigma, a preliminary photon flux (from 100 MeV to 300 GeV) of (3.1 +/- 0.4) x 10^-6 ph/cm^2/s, and a power-law photon index of 2.6 +/- 0.1, quoted uncertainties are statistical only.

Fermi LAT Detection of Pulsed Gamma-Rays From the Vela-Like Pulsars PSR J1048-5832 and PSR J2229+6114

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdo, A.A.; /Naval Research Lab, Wash., D.C. /Federal City Coll.; Ackermann, M.

We report the detection of {gamma}-ray pulsations ({ge}0.1 GeV) from PSR J2229+6114 and PSR J1048-5832, the latter having been detected as a low-significance pulsar by EGRET. Data in the {gamma}-ray band were acquired by the Large Area Telescope (LAT) aboard the Fermi Gamma-ray Space Telescope, while the radio rotational ephemerides used to fold the {gamma}-ray light curves were obtained using the Green Bank Telescope, the Lovell telescope at Jodrell Bank, and the Parkes Telescope. The two young radio pulsars, located within the error circles of the previously unidentified EGRET sources 3EG J1048-5840 and 3EG J2227+6122, present spin-down characteristics similar tomore » the Vela pulsar. PSR J1048-5832 shows two sharp peaks at phases 0.15 {+-} 0.01 and 0.57 {+-} 0.01 relative to the radio pulse confirming the EGRET light curve, while PSR J2229+6114 presents a very broad peak at phase 0.49 {+-} 0.01. The {gamma}-ray spectra above 0.1 GeV of both pulsars are fit with power laws having exponential cutoffs near 3 GeV, leading to integral photon fluxes of (2.19 {+-} 0.22 {+-} 0.32) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J1048-5832 and (3.77 {+-} 0.22 {+-} 0.44) x 10{sup -7} cm{sup -2} s{sup -1} for PSR J2229+6114. The first uncertainty is statistical and the second is systematic. PSR J1048-5832 is one of the two LAT sources which were entangled together as 3EG J1048-5840. These detections add to the growing number of young {gamma}-ray pulsars that make up the dominant population of GeV {gamma}-ray sources in the Galactic plane.« less

The supernova remnant W49B as seen with H.E.S.S. and Fermi-LAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abdalla, H.; Abramowski, A.; Aharonian, F.

The supernova remnant (SNR) W49B originated from a core-collapse supernova that occurred between one and four thousand years ago, and subsequently evolved into a mixed-morphology remnant, which is interacting with molecular clouds (MC). Gamma-ray observations of SNR-MC associations are a powerful tool to constrain the origin of Galactic cosmic rays, as they can probe the acceleration of hadrons through their interaction with the surrounding medium and subsequent emission of non-thermal photons. Here, we report the detection of a γ-ray source coincident with W49B at very high energies (VHE; E > 100 GeV) with the H.E.S.S. Cherenkov telescopes together with amore » study of the source with five years of Fermi-LAT high-energy γ-ray (0.06–300 GeV) data. The smoothly connected, combined source spectrum, measured from 60 MeV to multi-TeV energies, shows two significant spectral breaks at 304 ± 20 MeV and 8.4 -2.5 +2.2 GeV; the latter is constrained by the joint fit from the two instruments. The detected spectral features are similar to those observed in several other SNR-MC associations and are found to be indicative of γ-ray emission produced through neutral-pion decay.« less

The supernova remnant W49B as seen with H.E.S.S. and Fermi-LAT

DOE PAGES

Abdalla, H.; Abramowski, A.; Aharonian, F.; ...

2018-04-01

The supernova remnant (SNR) W49B originated from a core-collapse supernova that occurred between one and four thousand years ago, and subsequently evolved into a mixed-morphology remnant, which is interacting with molecular clouds (MC). Gamma-ray observations of SNR-MC associations are a powerful tool to constrain the origin of Galactic cosmic rays, as they can probe the acceleration of hadrons through their interaction with the surrounding medium and subsequent emission of non-thermal photons. Here, we report the detection of a γ-ray source coincident with W49B at very high energies (VHE; E > 100 GeV) with the H.E.S.S. Cherenkov telescopes together with amore » study of the source with five years of Fermi-LAT high-energy γ-ray (0.06–300 GeV) data. The smoothly connected, combined source spectrum, measured from 60 MeV to multi-TeV energies, shows two significant spectral breaks at 304 ± 20 MeV and 8.4 -2.5 +2.2 GeV; the latter is constrained by the joint fit from the two instruments. The detected spectral features are similar to those observed in several other SNR-MC associations and are found to be indicative of γ-ray emission produced through neutral-pion decay.« less

KSC-08pd0781

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, a General Dynamics technician prepares to test the deployment mechanism on the solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0646

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- In the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, sits uncovered before its move to a work stand in the facility for a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd0763

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians lift one of twin solar arrays that will be installed on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0768

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, one of twin solar arrays awaits processing as General Dynamics technicians install the other of the pair on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd0782

NASA Image and Video Library

2008-03-21

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, a General Dynamics technician prepares to test the deployment mechanism of the solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Jim Grossmann

KSC-08pd0771

NASA Image and Video Library

2008-03-20

CAPE CANAVERAL, Fla. --- In the Astrotech payload processing facility, a General Dynamics technician finishes the installation of the second of twin solar arrays on NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

KSC-08pd1603

NASA Image and Video Library

2008-06-09

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center, key personnel brief the media on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, launch scheduled for June 11. From left are Dr. Jon Morse, director of NASA's Astrophysics Division; Omar Baez, NASA launch director/launch manager at Kennedy; Kris Walsh, director of the Delta NASA and Commercial Programs with United Launch Alliance; Kevin Grady, GLAST project manager at NASA's Goddard Space Flight Center; Dr. Steven Ritz, GLAST project scientist/astrophysicist at Goddard; and Joel Tumbiolo, the U.S. Air Force Delta II launch weather officer with the 45th Weather Squadron at Cape Canaveral Air Force Station. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd1604

NASA Image and Video Library

2008-06-09

CAPE CANAVERAL, Fla. -- At left, Public Information Officer George Diller moderates a media briefing on NASA's Gamma-Ray Large Area Space Telescope, or GLAST, launch scheduled for June 11. On the panel next to Diller are Dr. Jon Morse, director of NASA's Astrophysics Division; Omar Baez, NASA launch director/launch manager at Kennedy; Kris Walsh, director of the Delta NASA and Commercial Programs with United Launch Alliance; Kevin Grady, GLAST project manager at NASA's Goddard Space Flight Center; Dr. Steven Ritz, GLAST project scientist/astrophysicist at Goddard; and Joel Tumbiolo, the U.S. Air Force Delta II launch weather officer with the 45th Weather Squadron at Cape Canaveral Air Force Station. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Intrinsic Astrocyte Heterogeneity Influences Tumor Growth in Glioma Mouse Models.

PubMed

Irvin, David M; McNeill, Robert S; Bash, Ryan E; Miller, C Ryan

2017-01-01

The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating Rb and Pten and activating Kras transform astrocytes and induce tumorigenesis throughout the adult mouse brain. However, it remained unclear whether astrocyte subpopulations were susceptible to these mutations. We therefore used genetic lineage tracing and fate mapping in adult conditional, inducible genetically engineered mice to monitor transformation of glial fibrillary acidic protein (GFAP) and glutamate aspartate transporter (GLAST) astrocytes and immunofluorescence to monitor cellular composition of the tumor microenvironment over time. Because considerable regional heterogeneity exists among astrocytes, we also examined the influence of brain region on tumor growth. GFAP astrocyte transformation induced uniformly rapid, regionally independent tumor growth, but transformation of GLAST astrocytes induced slowly growing tumors with significant regional bias. Transformed GLAST astrocytes had reduced proliferative response in culture and in vivo and malignant progression was delayed in these tumors. Recruited glial cells, including proliferating astrocytes, oligodendrocyte progenitors and microglia, were the majority of GLAST, but not GFAP astrocyte-derived tumors and their abundance dynamically changed over time. These results suggest that intrinsic astrocyte heterogeneity, and perhaps regional brain microenvironment, significantly contributes to glioma pathogenesis. © 2016 International Society of Neuropathology.

Consolidative local ablative therapy improves the survival of patients with synchronous oligometastatic NSCLC harboring EGFR activating mutation treated with first-line EGFR-TKIs.

PubMed

Xu, Qinghua; Zhou, Fei; Liu, Hui; Jiang, Tao; Li, Xuefei; Xu, Yaping; Zhou, Caicun

2018-05-28

The aim of the current study was to investigate whether consolidative local ablative therapy (LAT) can improve the survival of patients with stage IV EGFR-mutant NSCLC who have oligometastatic disease treated with first-line EGFR-TKI therapy. Patients with stage IV EGFR-mutant NSCLC and no more than five metastases within 2 months of diagnosis were identified. All patients were treated with first-line EGFR-TKIs. Consolidative LAT included radiotherapy, surgery or both. Overall survival (OS) and progression-free survival (PFS) were estimated by Kaplan-Meier curves. From October 2010 to May 2016, 145 patients were enrolled, including 51 (35.2%) who received consolidative LAT to all oligometastatic sites (All-LAT group), 55 (37.9%) who received consolidative LAT to either primary tumor or oligometastatic sites (Part-LAT group), and 39 (26.9%) who did not receive any consolidative LAT (Non-LAT group). The median PFS in All-LAT, Part-LAT, and Non-LAT group were 20.6, 15.6, and 13.9 months, respectively (P<0.001). The median OS in All-LAT, Part-LAT, and Non-LAT group were 40.9, 34.1, and 30.8 months, respectively (P<0.001). The difference was statistically significant between All-LAT group and Part-LAT or Non-LAT group but was not between Part-LAT and Non-LAT group. The median OS was significantly improved with consolidative LAT for primary tumor (40.5 versus 31.5 months, P<0.001), brain metastases (38.2 versus 29.2 months, P=0.002), adrenal metastases (37.1 versus 29.2 months, P =0.032). Adverse events (Grade ≥ 3) due to radiotherapy included pneumonitis (7.7%) and esophagitis (16.9%). The current study demonstrated that consolidative LAT to all metastatic sites was a feasible option for patients with EGFR-mutant oligometastatic NSCLC during first-line EGFR-TKI treatment, with significantly improved PFS and OS compared with consolidative LAT to partial sites or observation alone. Copyright © 2018. Published by Elsevier Inc.

Fermi's Motion Produces a Study in Spirograph

NASA Image and Video Library

2017-12-08

The LAT's sensitivity to gamma rays is greatest in the center of its wide field of view and decreases toward the edge. LAT scientists regard the effective limit of the instrument's field of view to be 78.5 degrees (red circle) from its center. View a video of this here: bit.ly/Y2K4LN. Credit: NASA/DOE/Fermi LAT Collaboration ----- NASA's Fermi Gamma-ray Space Telescope orbits our planet every 95 minutes, building up increasingly deeper views of the universe with every circuit. Its wide-eyed Large Area Telescope (LAT) sweeps across the entire sky every three hours, capturing the highest-energy form of light -- gamma rays -- from sources across the universe. These range from supermassive black holes billions of light-years away to intriguing objects in our own galaxy, such as X-ray binaries, supernova remnants and pulsars. Now a Fermi scientist has transformed LAT data of a famous pulsar into a mesmerizing movie that visually encapsulates the spacecraft's complex motion. Click here to continue reading: 1.usa.gov/WhYwCU NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

FERMI LAT discovery of extended gamma-ray emissions in the vicinity of the HB 3 supernova remnant

DOE PAGES

Katagiri, H.; Yoshida, K.; Ballet, J.; ...

2016-02-11

We report the discovery of extended gamma-ray emission measured by the Large Area Tele- scope (LAT) onboard the Fermi Gamma-ray Space Telescope in the region of the supernova rem- nant (SNR) HB 3 (G132.7+1.3) and the W3 HII complex adjacent to the southeast of the remnant. W3 is spatially associated with bright 12CO (J=1-0) emission. The gamma-ray emission is spatially correlated with this gas and the SNR. We discuss the possibility that gamma rays originate in inter- actions between particles accelerated in the SNR and interstellar gas or radiation fields. The decay of neutral pions produced in nucleon-nucleon interactions betweenmore » accelerated hadrons and interstellar gas provides a reasonable explanation for the gamma-ray emission. The emission fromW3 is consistent with irradiation of the CO clouds by the cosmic rays accelerated in HB 3.« less

FERMI LAT DISCOVERY OF EXTENDED GAMMA-RAY EMISSIONS IN THE VICINITY OF THE HB 3 SUPERNOVA REMNANT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katagiri, H.; Yoshida, K.; Ballet, J.

2016-02-20

We report the discovery of extended gamma-ray emission measured by the Large Area Telescope (LAT) onboard the Fermi Gamma-ray Space Telescope in the region of the supernova remnant (SNR) HB 3 (G132.7+1.3) and the W3 II complex adjacent to the southeast of the remnant. W3 is spatially associated with bright {sup 12}CO (J = 1–0) emission. The gamma-ray emission is spatially correlated with this gas and the SNR. We discuss the possibility that gamma rays originate in interactions between particles accelerated in the SNR and interstellar gas or radiation fields. The decay of neutral pions produced in nucleon–nucleon interactions between accelerated hadrons and interstellar gas provides amore » reasonable explanation for the gamma-ray emission. The emission from W3 is consistent with irradiation of the CO clouds by the cosmic rays accelerated in HB 3.« less

Multiwavelength observations of the TeV binary LS I +61° 303 with Veritas, Fermi-LAT, and Swift/xrt during a TeV outburst

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aliu, E.; Archambault, S.; Behera, B.

2013-12-10

We present the results of a multiwavelength observational campaign on the TeV binary system LS I +61° 303 with the VERITAS telescope array (>200 GeV), Fermi-LAT (0.3-300 GeV), and Swift/XRT (2-10 keV). The data were taken from 2011 December through 2012 January and show a strong detection in all three wavebands. During this period VERITAS obtained 24.9 hr of quality selected livetime data in which LS I +61° 303 was detected at a statistical significance of 11.9σ. These TeV observations show evidence for nightly variability in the TeV regime at a post-trial significance of 3.6σ. The combination of the simultaneouslymore » obtained TeV and X-ray fluxes do not demonstrate any evidence for a correlation between emission in the two bands. For the first time since the launch of the Fermi satellite in 2008, this TeV detection allows the construction of a detailed MeV-TeV spectral energy distribution from LS I +61° 303. This spectrum shows a distinct cutoff in emission near 4 GeV, with emission seen by the VERITAS observations following a simple power-law above 200 GeV. This feature in the spectrum of LS I +61° 303, obtained from overlapping observations with Fermi-LAT and VERITAS, may indicate that there are two distinct populations of accelerated particles producing the GeV and TeV emission.« less

Retinal glutamate transporter changes in experimental glaucoma and after optic nerve transection in the rat.

PubMed

Martin, Keith R G; Levkovitch-Verbin, Hana; Valenta, Danielle; Baumrind, Lisa; Pease, Mary Ellen; Quigley, Harry A

2002-07-01

High levels of glutamate can be toxic to retinal ganglion cells. Effective buffering of extracellular glutamate by retinal glutamate transporters is therefore important. This study was conducted to investigate whether glutamate transporter changes occur with two models of optic nerve injury in the rat. Glaucoma was induced in one eye of 35 adult Wistar rats by translimbal diode laser treatment to the trabecular meshwork. Twenty-five more rats underwent unilateral optic nerve transection. Two glutamate transporters, GLAST (EAAT-1) and GLT-1 (EAAT-2), were studied by immunohistochemistry and quantitative Western blot analysis. Treated and control eyes were compared 3 days and 1, 4, and 6 weeks after injury. Optic nerve damage was assessed semiquantitatively in epoxy-embedded optic nerve cross sections. Trabecular laser treatment resulted in moderate intraocular pressure (IOP) elevation in all animals. After 1 to 6 weeks of experimental glaucoma, all treated eyes had significant optic nerve damage. Glutamate transporter changes were not detected by immunohistochemistry. Western blot analysis demonstrated significantly reduced GLT-1 in glaucomatous eyes compared with control eyes at 3 days (29.3% +/- 6.7%, P = 0.01), 1 week (55.5% +/- 13.6%, P = 0.02), 4 weeks (27.2% +/- 10.1%, P = 0.05), and 6 weeks (38.1% +/- 7.9%, P = 0.01; mean reduction +/- SEM, paired t-tests, n = 5 animals per group, four duplicate Western blot analyses per eye). The magnitude of the reduction in GLT-1 correlated significantly with mean IOP in the glaucomatous eye (r(2) = 0.31, P = 0.01, linear regression). GLAST was significantly reduced (33.8% +/- 8.1%, mean +/- SEM) after 4 weeks of elevated IOP (P = 0.01, paired t-test, n = 5 animals per group). In contrast to glaucoma, optic nerve transection resulted in an increase in GLT-1 compared with the control eye (P = 0.01, paired t-test, n = 15 animals). There was no significant change in GLAST after transection. GLT-1 and GLAST were significantly

Anisotropies in the Diffuse Gamma-Ray Background Measured by the Fermi LAT

NASA Technical Reports Server (NTRS)

Ferrara, E. C.; McEnery, J. E.; Troja, E.

2012-01-01

The contribution of unresolved sources to the diffuse gamma-ray background could induce anisotropies in this emission on small angular scales. We analyze the angular power spectrum of the diffuse emission measured by the Fermi LAT at Galactic latitudes absolute value of b > 30 deg in four energy bins spanning 1 to 50 GeV. At multipoles l >= 155, corresponding to angular scales approx < 2 deg, angular power above the photon noise level is detected at > 99.99% CL in the 1-2 GeV, 2- 5 GeV, and 5- 10 GeV energy bins, and at > 99% CL at 10-50 GeV. Within each energy bin the measured angular power takes approximately the same value at all multipoles l >= 155, suggesting that it originates from the contribution of one or more unclustered source populations. The amplitude of the angular power normalized to the mean intensity in each energy bin is consistent with a constant value at all energies, C(sub p) / (I)(exp 2) = 9.05 +/- 0.84 x 10(exp -6) sr, while the energy dependence of C(sub p) is consistent with the anisotropy arising from one or more source populations with power-law photon spectra with spectral index Gamma (sub s) = 2.40 +/- 0.07. We discuss the implications of the measured angular power for gamma-ray source populations that may provide a contribution to the diffuse gamma-ray background.

KSC-08pd1134

NASA Image and Video Library

2008-05-03

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility in Titusville, Fla., technicians begin placing a protective cover over NASA's Gamma-ray Large Area Space Telescope, or GLAST, spacecraft. GLAST is being prepared for its move to the Hazardous Processing Facility for fueling. The GLAST is a powerful space observatory that will explore the universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date is still to be determined. Photo credit: NASA/Mike Kerley

KSC-08pd1414

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers secure the lines of the hoist that will lift the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0433

NASA Image and Video Library

2008-02-19

KENNEDY SPACE CENTER, FLA. -- At Cape Canaveral Air Force Station, the Delta II second stage for GLAST has arrived at Hangar M and is prepared for weighing. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, May 16 from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd1423

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers begin lowering the GLAST spacecraft into the opening above the Delta II second stage in the mobile service tower. GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1413

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers secure the lines of the hoist that will lift the GLAST spacecraft into the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd0432

NASA Image and Video Library

2008-02-19

KENNEDY SPACE CENTER, FLA. -- At Cape Canaveral Air Force Station, the Delta II second stage for GLAST has arrived at Hangar M and is moved into place for weighing. The Delta rocket will be used to launch the Gamma-Ray Large Area Space Telescope, or GLAST, May 16 from Launch Pad 17-B on CCAFS. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

KSC-08pd1422

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, workers help maneuver the GLAST spacecraft toward the opening above the Delta II second stage in the mobile service tower. GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1418

NASA Image and Video Library

2008-05-17

CAPE CANAVERAL, Fla. -- At pad 17-B at Cape Canaveral Air Force Station, the GLAST spacecraft continues its rise toward the upper level of the mobile service tower. In the tower, GLAST will be mated with the Delta II second stage. GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. The launch date is targeted no earlier than June 3. Photo credit: NASA/Kim Shiflett

KSC-08pd1360

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians check the placement of NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft on the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1352

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft is being prepared for a move to an payload attach fitting that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1357

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians begin lifting and moving NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft for its move to a payload attach fitting that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1353

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft is being prepared for a move to an payload attach fitting, in the foreground, that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1356

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians prepare the payload attach fitting that will receive NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1361

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians check the attachment of NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft on the payload attach fitting. The fitting will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

KSC-08pd1355

NASA Image and Video Library

2008-05-14

CAPE CANAVERAL, Fla. -- At the Astrotech payload processing facility, technicians prepare NASA's Gamma-Ray Large Area Space Telescope, or GLAST, spacecraft for its move to the payload attach fitting that will eventually be used to mate GLAST to the Delta II launch vehicle. The GLAST is a powerful space observatory that will explore the Universe's ultimate frontier, where nature harnesses forces and energies far beyond anything possible on Earth; probe some of science's deepest questions, such as what our Universe is made of, and search for new laws of physics; explain how black holes accelerate jets of material to nearly light speed; and help crack the mystery of stupendously powerful explosions known as gamma-ray bursts. A launch date still is to be determined. Photo credit: NASA/Jim Grossmann

GeV γ-ray Emission Detected by Fermi-LAT Probably Associated with the Thermal Composite Supernova Remnant Kesteven 41 in a Molecular Environment

NASA Astrophysics Data System (ADS)

Liu, Bing; Chen, Yang; Zhang, Xiao; Zhang, Gao-Yuan; Xing, Yi; Pannuti, Thomas G.

2015-08-01

Hadronic emission from supernova remnant (SNR)-molecular cloud (MC) association systems has been widely regarded as a probe of shock-accelerated cosmic-ray protons. Here, we report on the detection of a γ-ray emission source with a significance of 24σ in 0.2-300 GeV, projected to lie to the northwest of the thermal composite SNR Kesteven 41, using 5.6 years of Fermi-Large Area Telescope (LAT) observation data. No significant long-term variability in the energy range 0.2-300 GeV is detected around this source. The 3σ error circle, 0.09° in radius, covers the 1720 MHz OH maser and is essentially consistent with the location of the VLSR˜ -50 km s-1 MC with which the SNR interacts. The source emission has an exponential cutoff power-law spectrum with a photon index of 1.9 ± 0.1 and a cutoff energy of 4.0+/- 0.9 GeV, and the corresponding 0.2-300 GeV luminosity is ˜ 1.3× 1036 erg s-1 at a distance of 12 kpc. There is no radio pulsar in the 3σ circle responsible for the high γ-ray luminosity. While the inverse Compton scattering scenario would lead to difficulty in the electron energy budget, the source emission can naturally be explained by the hadronic interaction between the relativistic protons accelerated by the shock of SNR Kesteven 41 and the adjacent northwestern MC. In this paper, we present a list of Galactic thermal composite SNRs detected at GeV γ-ray energies by Fermi-LAT.

The Advanced Pair Telescope (APT) Mission Concept

NASA Technical Reports Server (NTRS)

Hunter, Stanley; Buckley, James H.

2008-01-01

We present a mission concept for the Advanced Pair Telescope (APT), a high-energy gamma-ray instrument with an order of magnitude improvement in sensitivity, 6 sr field of view, and angular resolution a factor of 3-10 times that of GLAST. With its very wide instantaneous field-of-view and large effective area, this instrument would be capable of detecting GRBs at very large redshifts, would enable a very high resolution study of SNRs and PWN, and could provide hour-scale temporal resolution of transients from many AGN and galactic sources. The APT instrument will consist of a Xe time-projection-chamber tracker that bridges the energy regime between Compton scattering and pair production and will provide an unprecedented improvement in angular resolution; a thick scintillating-fiber trackerlcalorimeter that will provide sensitivity and energy resolution to higher energies and will possess a factor of 10 improvement in geometric factor over GLAST; and an anticoincidence detector using scintillator-tiles to reject charged particles. After the anticipated 10-years of GLAST operation , the APT instrument would provide continued coverage of the critial high-energy gamma-ray band (between 30 MeV to 100 GeV), providing an essential component of broad-band multiwavelength studies of the high-energy universe.

Five New Millisecond Pulsars From A Radio Survey Of 14 Unidentified Fermi -Lat Gamma-Ray Sources

DOE PAGES

Kerr, M.; Camilo, F.; Johnson, T. J.; ...

2012-02-27

We have discovered five millisecond pulsars (MSPs) in a survey of 14 unidentified Fermi-LAT sources in the southern sky using the Parkes radio telescope. PSRs J0101–6422, J1514–4946, and J1902–5105 reside in binaries, while PSRs J1658–5324 and J1747–4036 are isolated. Using an ephemeris derived from timing observations of PSR J0101–6422 (P=2.57ms, DM=12 pc cm -3), we have detected γ-ray pulsations and measured its proper motion. Its γ-ray spectrum (a power law of Γ = 0.9 with a cutoff at 1.6GeV) and efficiency are typical of other MSPs, but its radio and γ-ray light curves challenge simple geometric models of emission. Themore » high success rate of this survey—enabled by selecting γ- ray sources based on their detailed spectral characteristics—and other similarly successful searches indicate that a substantial fraction of the local population of MSPs may soon be known.« less

Peri-adolescent drinking of ethanol and/or nicotine modulates astroglial glutamate transporters and metabotropic glutamate receptor-1 in female alcohol-preferring rats.

PubMed

Alasmari, Fawaz; Bell, Richard L; Rao, P S S; Hammad, Alaa M; Sari, Youssef

2018-07-01

Impairment in glutamate neurotransmission mediates the development of dependence upon nicotine (NIC) and ethanol (EtOH). Previous work indicates that continuous access to EtOH or phasic exposure to NIC reduces expression of the glutamate transporter-1 (GLT-1) and cystine/glutamate antiporter (xCT) but not the glutamate/aspartate transporter (GLAST). Additionally, metabotropic glutamate receptors (mGluRs) expression was affected following exposure to EtOH or NIC. However, little is known about the effects of EtOH and NIC co-consumption on GLT-1, xCT, GLAST, and mGluR1 expression. In this study, peri-adolescent female alcohol preferring (P) rats were given binge-like access to water, sucrose (SUC), SUC-NIC, EtOH, or EtOH-NIC for four weeks. The present study determined the effects of these reinforcers on GLT-1, xCT, GLAST, and mGluR1 expression in the nucleus accumbens (NAc), hippocampus (HIP) and prefrontal cortex (PFC). GLT-1 and xCT expression were decreased in the NAc following both SUC-NIC and EtOH-NIC. In addition, only xCT expression was downregulated in the HIP in both of these latter groups. Also, glutathione peroxidase (GPx) activity in the HIP was reduced following SUC, SUC-NIC, EtOH, and EtOH-NIC consumption. Similar to previous work, GLAST expression was not altered in any brain region by any of the reinforcers. However, mGluR1 expression was increased in the NAc in the SUC-NIC, EtOH, and EtOH-NIC groups. These results indicate that peri-adolescent binge-like drinking of EtOH or SUC with or without NIC may exert differential effects on astroglial glutamate transporters and receptors. Our data further parallel some of the previous findings observed in adult rats. Copyright © 2018. Published by Elsevier Inc.

Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture

PubMed Central

Inman, Melissa; Perng, Guey-Chuen; Henderson, Gail; Ghiasi, Homayon; Nesburn, Anthony B.; Wechsler, Steven L.; Jones, Clinton

2001-01-01

The latency-associated transcript (LAT) is the only abundant herpes simplex virus type 1 (HSV-1) transcript expressed during latency. In the rabbit eye model, LAT null mutants do not reactivate efficiently from latency. We recently demonstrated that the LAT null mutant dLAT2903 induces increased levels of apoptosis in trigeminal ganglia of infected rabbits compared to LAT+ strains (G.-C. Perng, C. Jones, J. Ciacci-Zarella, M. Stone, G. Henderson, A. Yokht, S. M. Slanina, F. M. Hoffman, H. Ghiasi, A. B. Nesburn, and C. S. Wechsler, Science 287:1500–1503, 2000).The same study also demonstrated that a plasmid expressing LAT nucleotides 301 to 2659 enhanced cell survival of transfected cells after induction of apoptosis. Consequently, we hypothesized that LAT enhances spontaneous reactivation in part, because it promotes survival of infected neurons. Here we report on the ability of plasmids expressing different portions of the 5′ end of LAT to promote cell survival after induction of apoptosis. A plasmid expressing the first 1.5 kb of LAT (LAT nucleotides 1 to 1499) promoted cell survival in neuro-2A (mouse neuronal) and CV-1 (monkey fibroblast) cells. A plasmid expressing just the first 811 nucleotides of LAT promoted cell survival less efficiently. Plasmids expressing the first 661 nucleotides or less of LAT did not promote cell survival. We previously showed that a mutant expressing just the first 1.5 kb of LAT has wild-type spontaneous reactivation in rabbits, and a mutant expressing just the first 811 nucleotides of LAT has a reactivation frequency higher than that of dLAT2903 but lower than that of wild-type virus. In addition, mutants reported here for the first time, expressing just the first 661 or 76 nucleotides of LAT, had spontaneous reactivation indistinguishable from that of the LAT null mutant dLAT2903. In summary, these studies provide evidence that there is a functional relationship between the ability of LAT to promote cell survival and its

Detection of the Small Magellanic Cloud in gamma-rays with Fermi/LAT

NASA Astrophysics Data System (ADS)

Abdo, A. A.; Ackermann, M.; Ajello, M.; Baldini, L.; Ballet, J.; Barbiellini, G.; Bastieri, D.; Bechtol, K.; Bellazzini, R.; Berenji, B.; Blandford, R. D.; Bloom, E. D.; Bonamente, E.; Borgland, A. W.; Bouvier, A.; Brandt, T. J.; Bregeon, J.; Brez, A.; Brigida, M.; Bruel, P.; Buehler, R.; Buson, S.; Caliandro, G. A.; Cameron, R. A.; Caraveo, P. A.; Carrigan, S.; Casandjian, J. M.; Cecchi, C.; Çelik, Ö.; Charles, E.; Chekhtman, A.; Cheung, C. C.; Chiang, J.; Ciprini, S.; Claus, R.; Cohen-Tanugi, J.; Conrad, J.; Dermer, C. D.; de Palma, F.; Digel, S. W.; Silva, E. Do Couto E.; Drell, P. S.; Dubois, R.; Dumora, D.; Favuzzi, C.; Fegan, S. J.; Fukazawa, Y.; Funk, S.; Fusco, P.; Gargano, F.; Gasparrini, D.; Gehrels, N.; Germani, S.; Giglietto, N.; Giordano, F.; Giroletti, M.; Glanzman, T.; Godfrey, G.; Grenier, I. A.; Grondin, M.-H.; Grove, J. E.; Guiriec, S.; Hadasch, D.; Harding, A. K.; Hayashida, M.; Hays, E.; Horan, D.; Hughes, R. E.; Jean, P.; Jóhannesson, G.; Johnson, A. S.; Johnson, W. N.; Kamae, T.; Katagiri, H.; Kataoka, J.; Kerr, M.; Knödlseder, J.; Kuss, M.; Lande, J.; Latronico, L.; Lee, S.-H.; Lemoine-Goumard, M.; Llena Garde, M.; Longo, F.; Loparco, F.; Lovellette, M. N.; Lubrano, P.; Makeev, A.; Martin, P.; Mazziotta, M. N.; McEnery, J. E.; Michelson, P. F.; Mitthumsiri, W.; Mizuno, T.; Monte, C.; Monzani, M. E.; Morselli, A.; Moskalenko, I. V.; Murgia, S.; Nakamori, T.; Naumann-Godo, M.; Nolan, P. L.; Norris, J. P.; Nuss, E.; Ohsugi, T.; Okumura, A.; Omodei, N.; Orlando, E.; Ormes, J. F.; Panetta, J. H.; Parent, D.; Pelassa, V.; Pepe, M.; Pesce-Rollins, M.; Piron, F.; Porter, T. A.; Rainò, S.; Rando, R.; Razzano, M.; Reimer, A.; Reimer, O.; Reposeur, T.; Ripken, J.; Ritz, S.; Romani, R. W.; Sadrozinski, H. F.-W.; Sander, A.; Saz Parkinson, P. M.; Scargle, J. D.; Sgrò, C.; Siskind, E. J.; Smith, D. A.; Smith, P. D.; Spandre, G.; Spinelli, P.; Strickman, M. S.; Strong, A. W.; Suson, D. J.; Takahashi, H.; Takahashi, T.; Tanaka, T.; Thayer, J. B.; Thayer, J. G.; Thompson, D. J.; Tibaldo, L.; Torres, D. F.; Tosti, G.; Tramacere, A.; Uchiyama, Y.; Usher, T. L.; Vandenbroucke, J.; Vasileiou, V.; Vilchez, N.; Vitale, V.; Waite, A. P.; Wang, P.; Winer, B. L.; Wood, K. S.; Yang, Z.; Ylinen, T.; Ziegler, M.

2010-11-01

Context. The flux of gamma rays with energies greater than 100 MeV is dominated by diffuse emission coming from cosmic-rays (CRs) illuminating the interstellar medium (ISM) of our Galaxy through the processes of Bremsstrahlung, pion production and decay, and inverse-Compton scattering. The study of this diffuse emission provides insight into the origin and transport of cosmic rays. Aims: We searched for gamma-ray emission from the Small Magellanic Cloud (SMC) in order to derive constraints on the cosmic-ray population and transport in an external system with properties different from the Milky Way. Methods: We analysed the first 17 months of continuous all-sky observations by the Large Area Telescope (LAT) of the Fermi mission to determine the spatial distribution, flux and spectrum of the gamma-ray emission from the SMC. We also used past radio synchrotron observations of the SMC to study the population of CR electrons specifically. Results: We obtained the first detection of the SMC in high-energy gamma rays, with an integrated >100 MeV flux of (3.7±0.7) × 10-8 ph cm-2 s-1, with additional systematic uncertainty of ≤16%. The emission is steady and from an extended source ~3° in size. It is not clearly correlated with the distribution of massive stars or neutral gas, nor with known pulsars or supernova remnants, but a certain correlation with supergiant shells is observed. Conclusions: The observed flux implies an upper limit on the average CR nuclei density in the SMC of ~15% of the value measured locally in the Milky Way. The population of high-energy pulsars of the SMC may account for a substantial fraction of the gamma-ray flux, which would make the inferred CR nuclei density even lower. The average density of CR electrons derived from radio synchrotron observations is consistent with the same reduction factor but the uncertainties are large. From our current knowledge of the SMC, such a low CR density does not seem to be due to a lower rate of CR

KSC-08pd0767

NASA Image and Video Library

2008-03-20

KENNEDY SPACE CENTER, FLA. - In the Astrotech payload processing facility, General Dynamics technicians use a socket wrench equipped with a torque meter to tighten the bolts holding one of twin solar arrays to NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Chris Rhodes

Cosmic-Ray Background Flux Model based on a Gamma-Ray Large-Area Space Telescope Balloon Flight Engineering Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mizuno, T

2004-09-03

Cosmic-ray background fluxes were modeled based on existing measurements and theories and are presented here. The model, originally developed for the Gamma-ray Large Area Space Telescope (GLAST) Balloon Experiment, covers the entire solid angle (4{pi} sr), the sensitive energy range of the instrument ({approx} 10 MeV to 100 GeV) and abundant components (proton, alpha, e{sup -}, e{sup +}, {mu}{sup -}, {mu}{sup +} and gamma). It is expressed in analytic functions in which modulations due to the solar activity and the Earth geomagnetism are parameterized. Although the model is intended to be used primarily for the GLAST Balloon Experiment, model functionsmore » in low-Earth orbit are also presented and can be used for other high energy astrophysical missions. The model has been validated via comparison with the data of the GLAST Balloon Experiment.« less

Cosmic-Ray Background Flux Model Baed on a Gamma-Ray Large Area Space Telescope Baloon Flight Engineering

NASA Technical Reports Server (NTRS)

2002-01-01

Cosmic-ray background fluxes were modeled based on existing measurements and theories and are presented here. The model, originally developed for the Gamma-ray Large Area Space Telescope (GLAST) Balloon Experiment, covers the entire solid angle (4(pi) sr), the sensitive energy range of the instrument ((approx) 10 MeV to 100 GeV) and abundant components (proton, alpha, e(sup -), e(sup +), (mu)(sup -), (mu)(sup +) and gamma). It is expressed in analytic functions in which modulations due to the solar activity and the Earth geomagnetism are parameterized. Although the model is intended to be used primarily for the GLAST Balloon Experiment, model functions in low-Earth orbit are also presented and can be used for other high energy astrophysical missions. The model has been validated via comparison with the data of the GLAST Balloon Experiment.

The host galaxy and Fermi -LAT counterpart of HESS J1943+213

DOE PAGES

Peter, D.; Domainko, W.; Sanchez, D. A.; ...

2014-11-06

The very-high energy (VHE, E> 100 GeV) gamma-ray sky shows diverse Galactic and extragalactic source populations. For some sources the astrophysical object class could not be identified so far. The nature (Galactic or extragalactic) of the VHE gamma-ray source HESS J1943+213 is explored. We specifically investigate the proposed near-infrared counterpart 2MASS J19435624+2118233 of HESS J1943+213 and investigate the implications of a physical association. We present K-band imaging from the 3.5 m CAHA telescope of 2MASS J19435624+2118233. Furthermore, 5 years of Fermi-LAT data were analyzed to search for a high-energy (HE, 100 MeV stat ± 0.6 sys) × 10 -15 cmmore » -2 s -1 MeV -1 at the decorrelation energy Edec = 15.1 GeV and a spectral index of Γ = 1.59 ± 0.19stat ± 0.13sys. This gamma-ray spectrum shows a rather sharp break between the HE and VHE regimes of ΔΓ = 1.47 ± 0.36. In conclusion, the infrared and HE data strongly favor an extragalactic origin of HESS J1943+213, where the infrared counterpart traces the host galaxy of an extreme blazar and where the rather sharp spectral break between the HE and VHE regime indicates attenuation on extragalactic background light. The source is most likely located at a redshift between 0.03 and 0.45 according to extension and EBL attenuation arguments.« less

Constraints on dark matter models from a Fermi LAT search for high-energy cosmic-ray electrons from the Sun

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ajello, M.; Atwood, W. B.; Baldini, L.

During its first year of data taking, the Large Area Telescope (LAT) onboard the Fermi Gamma-Ray Space Telescope has collected a large sample of high-energy cosmic-ray electrons and positrons (CREs). We present the results of a directional analysis of the CRE events, in which we searched for a flux excess correlated with the direction of the Sun. Two different and complementary analysis approaches were implemented, and neither yielded evidence of a significant CRE flux excess from the Sun. Here, we derive upper limits on the CRE flux from the Sun’s direction, and use these bounds to constrain two classes ofmore » dark matter models which predict a solar CRE flux: (1) models in which dark matter annihilates to CREs via a light intermediate state, and (2) inelastic dark matter models in which dark matter annihilates to CREs.« less

Constraints on dark matter models from a Fermi LAT search for high-energy cosmic-ray electrons from the Sun

DOE PAGES

Ajello, M.; Atwood, W. B.; Baldini, L.; ...

2011-08-15

During its first year of data taking, the Large Area Telescope (LAT) onboard the Fermi Gamma-Ray Space Telescope has collected a large sample of high-energy cosmic-ray electrons and positrons (CREs). We present the results of a directional analysis of the CRE events, in which we searched for a flux excess correlated with the direction of the Sun. Two different and complementary analysis approaches were implemented, and neither yielded evidence of a significant CRE flux excess from the Sun. Here, we derive upper limits on the CRE flux from the Sun’s direction, and use these bounds to constrain two classes ofmore » dark matter models which predict a solar CRE flux: (1) models in which dark matter annihilates to CREs via a light intermediate state, and (2) inelastic dark matter models in which dark matter annihilates to CREs.« less

Uncertainty, Sensitivity Analysis, and Causal Identification in the Arctic using a Perturbed Parameter Ensemble of the HiLAT Climate Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunke, Elizabeth Clare; Urrego Blanco, Jorge Rolando; Urban, Nathan Mark

Coupled climate models have a large number of input parameters that can affect output uncertainty. We conducted a sensitivity analysis of sea ice proper:es and Arc:c related climate variables to 5 parameters in the HiLAT climate model: air-ocean turbulent exchange parameter (C), conversion of water vapor to clouds (cldfrc_rhminl) and of ice crystals to snow (micro_mg_dcs), snow thermal conduc:vity (ksno), and maximum snow grain size (rsnw_mlt). We used an elementary effect (EE) approach to rank their importance for output uncertainty. EE is an extension of one-at-a-time sensitivity analyses, but it is more efficient in sampling multi-dimensional parameter spaces. We lookedmore » for emerging relationships among climate variables across the model ensemble, and used causal discovery algorithms to establish potential pathways for those relationships.« less

Search for a gamma-ray line feature from a group of nearby galaxy clusters with Fermi LAT Pass 8 data

NASA Astrophysics Data System (ADS)

Liang, Yun-Feng; Shen, Zhao-Qiang; Li, Xiang; Fan, Yi-Zhong; Huang, Xiaoyuan; Lei, Shi-Jun; Feng, Lei; Liang, En-Wei; Chang, Jin

2016-05-01

Galaxy clusters are the largest gravitationally bound objects in the Universe and may be suitable targets for indirect dark matter searches. With 85 months of Fermi LAT Pass 8 publicly available data, we analyze the gamma-ray emission in the direction of 16 nearby galaxy clusters with an unbinned likelihood analysis. No statistically or globally significant γ -ray line feature is identified and a tentative line signal may present at ˜43 GeV . The 95% confidence level upper limits on the velocity-averaged cross section of dark matter particles annihilating into double γ rays (i.e., ⟨σ v ⟩χχ →γ γ) are derived. Unless very optimistic boost factors of dark matter annihilation in these galaxy clusters have been assumed, such constraints are much weaker than the bounds set by the Galactic γ -ray data.

Glutamate transporter-dependent mTOR phosphorylation in Müller glia cells

PubMed Central

María López-Colomé, Ana; Martínez-Lozada, Zila; Guillem, Alain M; López, Edith; Ortega, Arturo

2012-01-01

Glu (glutamate), the excitatory transmitter at the main signalling pathway in the retina, is critically involved in changes in the protein repertoire through the activation of signalling cascades, which regulate protein synthesis at transcriptional and translational levels. Activity-dependent differential gene expression by Glu is related to the activation of ionotropic and metabotropic Glu receptors; however, recent findings suggest the involvement of Na+-dependent Glu transporters in this process. Within the retina, Glu uptake is aimed at the replenishment of the releasable pool, and for the prevention of excitotoxicity and is carried mainly by the GLAST/EAAT-1 (Na+-dependent glutamate/aspartate transporter/excitatory amino acids transporter-1) located in Müller radial glia. Based on the previous work showing the alteration of GLAST expression induced by Glu, the present work investigates the involvement of GLAST signalling in the regulation of protein synthesis in Müller cells. To this end, we explored the effect of D-Asp (D-aspartate) on Ser-2448 mTOR (mammalian target of rapamycin) phosphorylation in primary cultures of chick Müller glia. The results showed that D-Asp transport induces the time- and dose-dependent phosphorylation of mTOR, mimicked by the transportable GLAST inhibitor THA (threo-β-hydroxyaspartate). Signalling leading to mTOR phosphorylation includes Ca2+ influx, the activation of p60src, phosphatidylinositol 3-kinase, protein kinase B, mTOR and p70S6K. Interestingly, GLAST activity promoted AP-1 (activator protein-1) binding to DNA, supporting a function for transporter signalling in retinal long-term responses. These results add a novel receptor-independent pathway for Glu signalling in Müller glia, and further strengthen the critical involvement of these cells in the regulation of glutamatergic transmission in the retina. PMID:22817638

Expression and functional characterisation of System L amino acid transporters in the human term placenta.

PubMed

Gaccioli, Francesca; Aye, Irving L M H; Roos, Sara; Lager, Susanne; Ramirez, Vanessa I; Kanai, Yoshikatsu; Powell, Theresa L; Jansson, Thomas

2015-06-09

System L transporters LAT1 (SLC7A5) and LAT2 (SLC7A8) mediate the uptake of large, neutral amino acids in the human placenta. Many System L substrates are essential amino acids, thus representing crucial nutrients for the growing fetus. Both LAT isoforms are expressed in the human placenta, but the relative contribution of LAT1 and LAT2 to placental System L transport and their subcellular localisation are not well established. Moreover, the influence of maternal body mass index (BMI) on placental System L amino acid transport is poorly understood. Therefore the aims of this study were to determine: i) the relative contribution of the LAT isoforms to System L transport activity in primary human trophoblast (PHT) cells isolated from term placenta; ii) the subcellular localisation of LAT transporters in human placenta; and iii) placental expression and activity of System L transporters in response to maternal overweight/obesity. System L mediated leucine uptake was measured in PHT cells after treatment with si-RNA targeting LAT1 and/or LAT2. The localisation of LAT isoforms was studied in isolated microvillous plasma membranes (MVM) and basal membranes (BM) by Western blot analysis. Results were confirmed by immunohistochemistry in sections of human term placenta. Expression and activity System L transporters was measured in isolated MVM from women with varying pre-pregnancy BMI. Both LAT1 and LAT2 isoforms contribute to System L transport activity in primary trophoblast cells from human term placenta. LAT1 and LAT2 transporters are highly expressed in the MVM of the syncytiotrophoblast layer at term. LAT2 is also localised in the basal membrane and in endothelial cells lining the fetal capillaries. Measurements in isolated MVM vesicles indicate that System L transporter expression and activity is not influenced by maternal BMI. LAT1 and LAT2 are present and functional in the syncytiotrophoblast MVM, whereas LAT2 is also expressed in the BM and in the fetal capillary

KSC-08pd0645

NASA Image and Video Library

2008-03-05

KENNEDY SPACE CENTER, FLA. -- General Dynamics technicians in the Astrotech payload processing facility remove the protective cover over NASA's Gamma-Ray Large Area Space Telescope, or GLAST. The space telescope will be moved to a work stand in the facility for a complete checkout of the scientific instruments aboard. The telescope will launch aboard a Delta II rocket May 16 from Launch Pad 17-B on Cape Canaveral Air Force Station. A powerful space observatory, the GLAST will explore the most extreme environments in the universe, and answer questions about supermassive black hole systems, pulsars and the origin of cosmic rays. It also will study the mystery of powerful explosions known as gamma-ray bursts. Photo credit: NASA/Kim Shiflett

Identification of two small RNAs within the first 1.5-kb of the herpes simplex virus type 1-encoded latency-associated transcript.

PubMed

Peng, Weiping; Vitvitskaia, Olga; Carpenter, Dale; Wechsler, Steven L; Jones, Clinton

2008-01-01

The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) is abundantly expressed in latently infected neurons. In the rabbit or mouse ocular models of infection, expression of the first 1.5 kb of LAT coding sequences is sufficient for and necessary for wild-type levels of spontaneous reactivation from latency. The antiapoptosis functions of LAT, which maps to the same 1.5 kb of LAT, are important for the latency-reactivation cycle because replacement of LAT with other antiapoptosis genes (the baculovirus IAP gene or the bovine herpesvirus type 1 latency-related gene) restores wild-type levels of reactivation to a LAT null mutant. A recent study identified a micro-RNA within LAT that can inhibit apoptosis (Gupta et al, Nature 442: 82-85). In this study, the authors analyzed the first 1.5 kb of LAT for additional small RNAs that may have regulatory functions. Two LAT-specific small RNAs were detected in productively infected human neuroblastoma cells within the first 1.5 kb of LAT, in a region that is important for inhibiting apoptosis. Although these small RNAs possess extensive secondary structure and a stem-loop structure, bands migrating near 23 bases were not detected suggesting these small RNAs are not true micro-RNAs. Both of the small LAT-specific RNAs have the potential to base pair with the ICP4 mRNA. These two small LAT RNAs may play a role in the latency-reactivation cycle by reducing apoptosis and/or by reducing ICP4 RNA expression.

Detection of the Small Magellanic Cloud in gamma-rays with  Fermi /LAT

DOE PAGES

Abdo, A. A.

2010-11-01

Context. The flux of gamma rays with energies greater than 100 MeV is dominated by diffuse emission coming from cosmic-rays (CRs) illuminating the interstellar medium (ISM) of our Galaxy through the processes of Bremsstrahlung, pion production and decay, and inverse-Compton scattering. The study of this diffuse emission provides insight into the origin and transport of cosmic rays. Aims. We searched for gamma-ray emission from the Small Magellanic Cloud (SMC) in order to derive constraints on the cosmic-ray population and transport in an external system with properties different from the Milky Way. Methods. We analysed the first 17 months of continuousmore » all-sky observations by the Large Area Telescope (LAT) of the Fermi mission to determine the spatial distribution, flux and spectrum of the gamma-ray emission from the SMC. We also used past radio synchrotron observations of the SMC to study the population of CR electrons specifically. Results. We obtained the first detection of the SMC in high-energy gamma rays, with an integrated >100 MeV flux of (3.7 ± 0.7) × 10 -8 ph cm -2 s -1, with additional systematic uncertainty of ≤16%. The emission is steady and from an extended source ~3° in size. It is not clearly correlated with the distribution of massive stars or neutral gas, nor with known pulsars or supernova remnants, but a certain correlation with supergiant shells is observed. Conclusions. The observed flux implies an upper limit on the average CR nuclei density in the SMC of ~15% of the value measured locally in the Milky Way. The population of high-energy pulsars of the SMC may account for a substantial fraction of the gamma-ray flux, which would make the inferred CR nuclei density even lower. The average density of CR electrons derived from radio synchrotron observations is consistent with the same reduction factor but the uncertainties are large. From our current knowledge of the SMC, such a low CR density does not seem to be due to a lower rate

Effects of Orally Administered Augmentin on Glutamate Transporter 1, Cystine-glutamate Exchanger Expression as well as Ethanol Intake in Alcohol-Preferring Rats

PubMed Central

Hakami, Alqassem Y.; Alshehri, Fahad S.; Althobaiti, Yusuf S.; Sari, Youssef

2016-01-01

Alcohol dependence is associated with deficits in glutamate uptake and impairment of glutamate homeostasis in different brain reward regions. Glutamate transporter subtype 1 (GLT-1), cystine-glutamate exchanger (xCT) and glutamate/aspartate transporter (GLAST) are the key players in regulating extracellular glutamate concentration in the brain. Parenteral treatment with ceftriaxone, β-lactam antibiotic, has been reported to attenuate ethanol consumption and reinstatement to cocaine-seeking behavior, in part, by restoring the expression of GLT-1 and xCT in mesocorticolimbic brain regions in rats. In this study, we focus to test Augmentin (amoxicillin/clavulanate), which can be administered orally to subjects. Therefore, we examined the effects of orally administered Augmentin on ethanol intake as well as GLT-1, xCT and GLAST expression in alcohol-preferring (P) rats. We found that orally administered Augmentin significantly attenuated ethanol consumption in P rats as compared to the vehicle-treated group. Importantly, the attenuation in ethanol consumption was associated with a significant upregulation of GLT-1 and xCT expression in nucleus accumbens (NAc) and prefrontal cortex (PFC). There was no effect of oral Augmentin on GLAST expression in either NAc or PFC. These findings present strong evidence that oral administration of Augmentin can be used as an alternative to parenteral administration. PMID:27993695

The Cosmic Ray Electron Excess

NASA Technical Reports Server (NTRS)

Chang, J.; Adams, J. H.; Ahn, H. S.; Bashindzhagyan, G. L.; Christl, M.; Ganel, O.; Guzik, T. G.; Isbert, J.; Kim, K. C.; Kuznetsov, E. N.;

Herpes simplex virus latency-associated transcript sequence downstream of the promoter influences type-specific reactivation and viral neurotropism.

PubMed

Bertke, Andrea S; Patel, Amita; Krause, Philip R

2007-06-01

Herpes simplex virus (HSV) establishes latency in sensory nerve ganglia during acute infection and may later periodically reactivate to cause recurrent disease. HSV type 1 (HSV-1) reactivates more efficiently than HSV-2 from trigeminal ganglia while HSV-2 reactivates more efficiently than HSV-1 from lumbosacral dorsal root ganglia (DRG) to cause recurrent orofacial and genital herpes, respectively. In a previous study, a chimeric HSV-2 that expressed the latency-associated transcript (LAT) from HSV-1 reactivated similarly to wild-type HSV-1, suggesting that the LAT influences the type-specific reactivation phenotype of HSV-2. To further define the LAT region essential for type-specific reactivation, we constructed additional chimeric HSV-2 viruses by replacing the HSV-2 LAT promoter (HSV2-LAT-P1) or 2.5 kb of the HSV-2 LAT sequence (HSV2-LAT-S1) with the corresponding regions from HSV-1. HSV2-LAT-S1 was impaired for reactivation in the guinea pig genital model, while its rescuant and HSV2-LAT-P1 reactivated with a wild-type HSV-2 phenotype. Moreover, recurrences of HSV-2-LAT-S1 were frequently fatal, in contrast to the relatively mild recurrences of the other viruses. During recurrences, HSV2-LAT-S1 DNA increased more in the sacral cord compared to its rescuant or HSV-2. Thus, the LAT sequence region, not the LAT promoter region, provides essential elements for type-specific reactivation of HSV-2 and also plays a role in viral neurotropism. HSV-1 DNA, as quantified by real-time PCR, was more abundant in the lumbar spinal cord, while HSV-2 DNA was more abundant in the sacral spinal cord, which may provide insights into the mechanism for type-specific reactivation and different patterns of central nervous system infection of HSV-1 and HSV-2.

Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism▿

PubMed Central

Bertke, Andrea S.; Patel, Amita; Krause, Philip R.

2007-01-01

Herpes simplex virus (HSV) establishes latency in sensory nerve ganglia during acute infection and may later periodically reactivate to cause recurrent disease. HSV type 1 (HSV-1) reactivates more efficiently than HSV-2 from trigeminal ganglia while HSV-2 reactivates more efficiently than HSV-1 from lumbosacral dorsal root ganglia (DRG) to cause recurrent orofacial and genital herpes, respectively. In a previous study, a chimeric HSV-2 that expressed the latency-associated transcript (LAT) from HSV-1 reactivated similarly to wild-type HSV-1, suggesting that the LAT influences the type-specific reactivation phenotype of HSV-2. To further define the LAT region essential for type-specific reactivation, we constructed additional chimeric HSV-2 viruses by replacing the HSV-2 LAT promoter (HSV2-LAT-P1) or 2.5 kb of the HSV-2 LAT sequence (HSV2-LAT-S1) with the corresponding regions from HSV-1. HSV2-LAT-S1 was impaired for reactivation in the guinea pig genital model, while its rescuant and HSV2-LAT-P1 reactivated with a wild-type HSV-2 phenotype. Moreover, recurrences of HSV-2-LAT-S1 were frequently fatal, in contrast to the relatively mild recurrences of the other viruses. During recurrences, HSV2-LAT-S1 DNA increased more in the sacral cord compared to its rescuant or HSV-2. Thus, the LAT sequence region, not the LAT promoter region, provides essential elements for type-specific reactivation of HSV-2 and also plays a role in viral neurotropism. HSV-1 DNA, as quantified by real-time PCR, was more abundant in the lumbar spinal cord, while HSV-2 DNA was more abundant in the sacral spinal cord, which may provide insights into the mechanism for type-specific reactivation and different patterns of central nervous system infection of HSV-1 and HSV-2. PMID:17409161