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Sample records for glaxo smith kline

  1. GW-501516 GlaxoSmithKline/Ligand.

    PubMed

    Pelton, Patricia

    2006-04-01

    GlaxoSmithKline and Ligand are developing GW-501516, a peroxisome proliferator-activator receptor-delta agonist for the potential treatment of dyslipidemia. Phase II clinical trials of this compound are ongoing.

  2. Scientists in Sport, the 2012-Inspired GlaxoSmithKline Schools Outreach Programme

    ERIC Educational Resources Information Center

    Gadd, Mark

    2012-01-01

    The GlaxoSmithKline Scientists in Sport team have worked with 4science to provide resources and offer activities for use by schools to show the relevance of science in sport. Much of the content looks at anti-doping and the science involved with detecting the misuse of banned substances. Through the development of a website, this work can continue…

  3. Belimumab Human Genome Sciences/Cambridge Antibody Technology/GlaxoSmithKline.

    PubMed

    Ding, Changhai; Jones, Graeme

    2006-05-01

    Belimumab, the lead in a series of human monoclonal antibodies against the human protein B-lymphocyte stimulator (BLyS), is under development by Human Genome Sciences, Cambridge Antibody Technology and GlaxoSmithKline for the potential treatment of autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). By January 2006, belimumab had completed phase II clinical trials in SLE and RA; a phase III clinical SLE trial is scheduled to begin later this year.

  4. GlaxoSmithKline and Merck: private-sector collaboration for the elimination of lymphatic filariasis.

    PubMed

    Gustavsen, K M; Bradley, M H; Wright, A L

    2009-10-01

    More than 1000 million people in 82 countries are at risk of contracting the tropical disease lymphatic filariasis (LF). Although the disease is wide-spread, transmission of the causative parasites can be stopped through mass drug administrations based on a combination of anti-parasitic medicines. For more than 10 years, the pharmaceutical companies GlaxoSmithKline (GSK) and Merck & Co., Inc., have participated in a unique private-sector collaboration to support the global efforts to eliminate LF, through donations of drugs to prevent the disease. GSK's albendazole and Merck's ivermectin (Mectizan) now reach hundreds of millions of people each year, through national LF-elimination programmes carried out in collaboration with Ministries of Health, the World Health Organization, non-governmental organizations and local communities. Working in support of the Global Programme to Eliminate Lymphatic Filariasis, GSK and Merck not only provide donated medicines but also offer financial, programmatic and management expertise to support LF-elimination efforts worldwide.

  5. 78 FR 63226 - GlaxoSmithKline LLC; Withdrawal of Approval of the Indication for Treatment of Patients With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... (tositumomab and iodine I 131 tositumomab) Injection held by GlaxoSmithKline LLP, P.O. Box 5089, 1250 South... and iodine I 131 tositumomab) Injection because the postmarketing study intended to verify clinical... rituximab-na ve indication for BEXXAR (tositumomab and iodine I 131 tositumomab) Injection from the...

  6. Passing on the medicinal chemistry baton: training undergraduates to be industry-ready through research projects between the University of Nottingham and GlaxoSmithKline.

    PubMed

    Macdonald, Simon J F; Fray, M Jonathan; McInally, Thomas

    2016-06-01

    In this article we describe a radically different industry-academia collaboration between the School of Chemistry, University of Nottingham, and GlaxoSmithKline (GSK), aiming to train students in research and give them an insight into medicinal chemistry as practiced in industry. The project concerns the discovery of potent and selective αvβ6 integrin antagonists to treat idiopathic pulmonary fibrosis; the synthetic chemistry is performed by a group of ten final-year undergraduates and the biological and physicochemical screening data are generated by GSK. The project planning, organisation and operation are discussed, together with some of the challenges and rewards of working with undergraduates.

  7. How SmithKline Beecham makes better resource-allocation decisions.

    PubMed

    Sharpe, P; Keelin, T

    1998-01-01

    Major resource-allocation decisions are never easy. For a pharmaceuticals company like SmithKline Beecham, the problem is this: How do you make good decisions in a high-risk, technically complex business when the information you need to make those decisions comes largely from the project champions who are competing against one another for resources? In 1993, the company experimented with ways of depoliticizing the process and improving the quality of decision making. In most resource-allocation processes, project advocates develop a single plan of action and present it as the only viable approach. In SB's new process, the company found an effective way to get around the all-or-nothing thinking that only reinforces the project-champion culture. Project teams were required--and helped--to create meaningful alternatives to current development plans. What would they do with more money? With less? With none at all? In another important departure from common practice, SB separated the discussion of project alternatives from their financial evaluations. In doing so, SB was able to avoid the premature evaluations that kill both creativity and the opportunity to improve decision making. The new process at SB has allowed the organization to spend less time arguing about how to value its R&D projects and more time figuring out how to make them more valuable. In the end, the company learned that by tackling the soft issues around resource allocation--such as information quality, credibility, and trust--it had also addressed the hard ones: how much to invest and where to invest it.

  8. Quantitative signal detection for vaccines: effects of stratification, background and masking on GlaxoSmithKline's spontaneous reports database.

    PubMed

    Zeinoun, Ziad; Seifert, Harry; Verstraeten, Thomas

    2009-09-01

    Disproportionality analyses are increasingly gaining acceptance as signal detection tools for drug adverse events. Their application to vaccine adverse events has not been well evaluated. Disproportionality analyses based on the Multi-Item Gamma Poisson Shrinkage principle (MGPS) were applied to spontaneous adverse events reports for five vaccines with different reporting profiles. Sensitivity analyses were used to assess the potential impact of changing key parameters. We used the Company's in-house spontaneous adverse events database. We evaluated the impact of stratification, the comparator dataset and the potential for masking. We conducted a semi-quantitative assessment by comparing the changes in the disproportionality scores and the number of vaccine-event pairs that exceeded an arbitrary threshold as a measure of the impact of any of these choices. The results show that stratification by age and region has a significant impact. The effect of the comparator dataset was dependent on the vaccine being evaluated. The potential for a masking effect was only weakly noticeable. In conclusion, we opt to start with a conservative approach in which we will supplement our primary stratification against the vaccine database with unstratified analyses as well as analyses against the entire database. We recommend that similar studies be performed before introducing disproportionality analyses to a new vaccine adverse events database.

  9. Better neutralization of herpes simplex virus type 1 (HSV-1) than HSV-2 by antibody from recipients of GlaxoSmithKline HSV-2 glycoprotein D2 subunit vaccine.

    PubMed

    Awasthi, Sita; Belshe, Robert B; Friedman, Harvey M

    2014-08-15

    The Herpevac Trial evaluated a herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit vaccine to prevent genital herpes. Unexpectedly, the vaccine protected against genital HSV-1 infection but not genital HSV-2 infection. We evaluated sera from 30 women seronegative for HSV-1 and HSV-2 who were immunized with gD2 in the Herpevac Trial. Neutralizing antibody titers to HSV-1 were 3.5-fold higher than those to HSV-2 (P < .001). HSV-2 gC2 and gE2 on the virus blocked neutralization by gD2 antibody, while HSV-1 gC1 and gE1 did not block neutralization by gD2 antibody. The higher neutralizing antibody titers to HSV-1 offer an explanation for the Herpevac results, and shielding neutralizing domains provides a potential mechanism.

  10. Scanner K-line photometry of Orion stars

    NASA Technical Reports Server (NTRS)

    Hesser, J. E.; Mcclintock, W.; Henry, R. C.

    1977-01-01

    Results are presented for two-channel scanner measurements of calcium K-line strengths in 39 Orion sword and belt stars. Values of the calcium k index and its associated standard error are given for each observed star, and the K-line strengths are compared with those of K-line standard stars and Hyades stars. Plots of k index against reddening-corrected color and of k-index deviation against metal-strength index deviation are provided which show that the Orion sword and belt stars do not differ significantly in their calcium and metal abundances from general field stars.

  11. Supercomputers Join the Fight against Cancer – U.S. Department of Energy

    SciTech Connect

    2016-06-29

    The Department of Energy has some of the best supercomputers in the world. Now, they’re joining the fight against cancer. Learn about our new partnership with the National Cancer Institute and GlaxoSmithKline Pharmaceuticals.

  12. Pharma giants swap research programs.

    PubMed

    2014-07-01

    Pharmaceutical giants Novartis and GlaxoSmithKline (GSK) agreed in late April to swap some assets, with Novartis handing off its vaccine business to GSK and getting most of the British company's cancer portfolio in return.

  13. Identifying the Right Disease Targets to Develop Better Drugs, Faster | NIH MedlinePlus the Magazine

    MedlinePlus

    ... added. Accelerating Medicines Partnership (AMP) Alzheimer's Disease The Partners Government NIH Industry AbbVie Biogen Idec GlaxoSmithKline Lilly ... Beene Foundation USAgainst Alzheimers Type 2 Diabetes The Partners Government NIH Industry Johnson & Johnson Lilly Merck Pfizer ...

  14. Glaxo's AZT announcement welcomed, but detail is yet to follow. mother-to-child transmission.

    PubMed

    Worthington, H

    1998-04-01

    Following recently completed trials of AZT in Thailand among pregnant women which showed that a short course of AZT can significantly reduce the mother-to-child transmission of HIV, Glaxo Wellcome recently announced that it will supply the antiretroviral drug AZT at a preferential price for pregnant women infected with HIV in developing countries. Since the size of the HIV/AIDS epidemic and the quantity of AZT needed cannot be predicted, Glaxo Wellcome has stated that it is unfeasible to implement a mass donation program of the drug. The preferential public sector pricing was instead arrived at after 3 years of discussions and collaboration with UNAIDS, governments, and nongovernmental organizations (NGOs). Glaxo and UNAIDS both agree that the pricing will be a price reduction and not a subsidy, but additional details remain unclear. Eligible countries will be defined according to World Health Organization guidelines, with UNICEF likely to play a key role in the AZT's distribution.

  15. Robert Smith.

    ERIC Educational Resources Information Center

    Pietrzak, Dale; L'Amoreaux, Nadene

    1998-01-01

    Interviews Robert Smith, executive director of the International Association of Marriage and Family Counselors (IAMFC), a division of the American Counseling Association. He has been involved with the IAMFC from its beginning and is in a position to provide both a historical perspective and a vision of the division's future. (Author/MKA)

  16. ERP Modulation during Observation of Abstract Paintings by Franz Kline

    PubMed Central

    Sbriscia-Fioretti, Beatrice; Berchio, Cristina; Freedberg, David; Gallese, Vittorio; Umiltà, Maria Alessandra

    2013-01-01

    The aim of this study was to test the involvement of sensorimotor cortical circuits during the beholding of the static consequences of hand gestures devoid of any meaning.In order to verify this hypothesis we performed an EEG experiment presenting to participants images of abstract works of art with marked traces of brushstrokes. The EEG data were analyzed by using Event Related Potentials (ERPs). We aimed to demonstrate a direct involvement of sensorimotor cortical circuits during the beholding of these selected works of abstract art. The stimuli consisted of three different abstract black and white paintings by Franz Kline. Results verified our experimental hypothesis showing the activation of premotor and motor cortical areas during stimuli observation. In addition, abstract works of art observation elicited the activation of reward-related orbitofrontal areas, and cognitive categorization-related prefrontal areas. The cortical sensorimotor activation is a fundamental neurophysiological demonstration of the direct involvement of the cortical motor system in perception of static meaningless images belonging to abstract art. These results support the role of embodied simulation of artist’s gestures in the perception of works of art. PMID:24130693

  17. Stephen Jay Kline on systems, or physics, complex systems, and the gap between.

    SciTech Connect

    Campbell, Philip LaRoche

    2011-06-01

    At the end of his life, Stephen Jay Kline, longtime professor of mechanical engineering at Stanford University, completed a book on how to address complex systems. The title of the book is 'Conceptual Foundations of Multi-Disciplinary Thinking' (1995), but the topic of the book is systems. Kline first establishes certain limits that are characteristic of our conscious minds. Kline then establishes a complexity measure for systems and uses that complexity measure to develop a hierarchy of systems. Kline then argues that our minds, due to their characteristic limitations, are unable to model the complex systems in that hierarchy. Computers are of no help to us here. Our attempts at modeling these complex systems are based on the way we successfully model some simple systems, in particular, 'inert, naturally-occurring' objects and processes, such as what is the focus of physics. But complex systems overwhelm such attempts. As a result, the best we can do in working with these complex systems is to use a heuristic, what Kline calls the 'Guideline for Complex Systems.' Kline documents the problems that have developed due to 'oversimple' system models and from the inappropriate application of a system model from one domain to another. One prominent such problem is the Procrustean attempt to make the disciplines that deal with complex systems be 'physics-like.' Physics deals with simple systems, not complex ones, using Kline's complexity measure. The models that physics has developed are inappropriate for complex systems. Kline documents a number of the wasteful and dangerous fallacies of this type.

  18. Short-course AZT reduces HIV transmission to infants; Glaxo cuts AZT price for developing countries.

    PubMed

    Baker, R

    1998-04-01

    A four-week AZT treatment recently tested by the Centers for Disease Control and Prevention (CDC) and health officials in Thailand revealed reductions in mother-to-infant transmission by 50 percent. The treatment offers hope to HIV-positive pregnant women in developing countries who do not have access to the full-course treatment common in the United States. Critics have charged that the study was unethical because some women were given placebos. The manufacturer, Glaxo Wellcome, is dropping AZT prices by 75 percent. The drug treatment and testing will cost about $100, instead of the $800 to $1,000 that the full treatment costs. Even with the price break, many feel that developed countries will need to heavily subsidize the programs to reduce the number of infant infections, now estimated at 550,000 per year.

  19. A possible edge effect in enhanced network. [solar K-line observations by multichannel spectrometer

    NASA Technical Reports Server (NTRS)

    Jones, H. P.; Brown, D. R.

    1977-01-01

    K-line observations of enhanced network taken with the NASA/SPO Multichannel Spectrometer on September 28, 1975, in support of OSO-8 are discussed. The data show a correlation between core brightness and asymmetry for spatial scans which cross enhanced network boundaries. The implications of this result concerning mass flow in and near supergranule boundaries are discussed.

  20. VizieR Online Data Catalog: K-Line Photometry of A Stars (Henry, 1969)

    NASA Astrophysics Data System (ADS)

    Henry, R. C.

    2016-11-01

    A narrow-band spectrometer, compensated for seeing and transparency variations, has been constructed and used to measure the strength of the calcium K-line (3933.68Å) in 146 A-type stars. The observations were made in the spring of 1966 with the No.4 16-inch (40cm) telescope at Kitt Peak National Observatory. (1 data file).

  1. Variability of Solar UV Irradiance Related to Bright Magnetic Features Observed in Call K-Line: Relationship between Lyman alpha and K-line Report for UARS funding agency

    NASA Technical Reports Server (NTRS)

    Zirin, Harold; Cameron, Robert

    1999-01-01

    In this report we comment on the relationship between the Lyman alpha and Calcium K-line emission from the Sun. We firstly examine resolved Lyman alpha images (from TRACE) and resolved K-line images. We find that the Lyman alpha emission is consistent with a linear dependence on the K-line emission. As this is in conflict with the analysis of Johannesson et al.(1995, 1998) we proceed by comparing the disk integrated Lyman alpha flux as a function of ratio between the disk integrated Mg II core and wing fluxes (Johannesson et al (1998) having previously found a linear dependence between this index and the BBSO K-line index). We find that a reasonably good fit can be obtained, however note the discrepancies which lead Johannesson et al to consider the square root relationship. We suggest an alternative interpretation of the discrepancy.

  2. Carrington Maps of Ca II K-line Emission for the Years 1915-1985

    NASA Astrophysics Data System (ADS)

    Sheeley, N. R., Jr.; Cooper, T. J.; Anderson, J. R. L.

    2011-03-01

    We have used Mount Wilson Observatory calcium K-line images, digitized and flat fielded by the solar group at UCLA, to construct Carrington maps of Ca II 3934 Å intensity for the years 1915-1985. These maps have a spatial resolution comparable to the resolution of Carrington maps of the magnetic field observed at Kitt Peak and a spectral resolution comparable to the width of the K232 emission. Consequently, they provide a way of tracking the spatial distribution of magnetic flux from the present back to the year 1915. In this paper, we compare some of the recent K-line maps with corresponding maps of magnetic field, and show examples of K-line maps during earlier sunspot cycles when high-quality magnetograms were not available. Then, we use butterfly diagrams and super-synoptic displays to summarize the long-term evolution of the patterns of calcium intensity. Although each cycle has characteristics that are similar to the others, cycle 19 is remarkable for its broad latitudinal distribution of active regions, for its giant poleward surges of flux, and for the emergence of a north-south asymmetry that lasted 10 years.

  3. Smith Tackles Oakland Unified

    ERIC Educational Resources Information Center

    Mellon, Ericka

    2011-01-01

    As a 20-something, Anthony "Tony" Smith had fulfilled one dream: playing professional football for the Green Bay Packers and the San Francisco 49ers. Next up, he thought, was law school, but a former mentor reminded him that he is a teacher. Smith never became a classroom teacher, but his background in sports--where he learned the power…

  4. Comparisons of MgII core-wing data with Ground-Based Ca K-line

    NASA Astrophysics Data System (ADS)

    Chapman, G. A.; Preminger, D.

    2011-12-01

    Magnesium_II core-wing ratio data will be compared with ground-based K-line photometry for most of cycle 22 and 23. The ground-based data is the photmetric sum computed from the composite K-line obtained from the San Fernando Observatory. We will examine several MgII core-wing composites. This work is partially supported by grants NNX11AB51G from NASA and ATM-0848518 from NSF.

  5. Developing WordSmith

    ERIC Educational Resources Information Center

    Scott, Mike

    2008-01-01

    WordSmith Tools, since its launch in 1996, has had a rather unusual history and the aim of this paper is to record some of the chief influences on its development. The paper thus presents and discusses the history of WordSmith Tools and its predecessors going back to the early 1980s when processors were much slower, memory very limited and disk…

  6. Carrington Maps of Ca II K-Line Emission for the Years 1915-1985

    DTIC Science & Technology

    2011-03-03

    contained relatively large numbers of faculae (Sheeley 2008) 6 The Astrophysical Journal, 730:51 (17pp), 2011 March 20 Sheeley, Cooper, & Anderson...The Astrophysical Journal, 730:51 (17pp), 2011 March 20 doi:10.1088/0004-637X/730/1/51 Copyright is not claimed for this article. All rights reserved... Astrophysical Journal, 730:51 (17pp), 2011 March 20 14. ABSTRACT We have used Mount Wilson Observatory calcium K-line images, digitized and flat fielded by the

  7. 75 FR 17929 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... HUMAN SERVICES Food and Drug Administration Vaccines and Related Biological Products Advisory Committee... be open to the public. Name of Committee: Vaccines and Related Biological Products Advisory Committee... circovirus type 1 (PCV 1) in Rotarix, a U.S. licensed vaccine manufactured by GlaxoSmithKline and...

  8. 77 FR 63839 - Vaccines and Related Biological Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... HUMAN SERVICES Food and Drug Administration Vaccines and Related Biological Products Advisory Committee... be open to the public. Name of Committee: Vaccines and Related Biological Products Advisory Committee... immunogenicity of an Influenza A (H5N1) Virus Monovalent Vaccine manufactured by GlaxoSmithKline. On November...

  9. Disconnected Youth in the Research Triangle Region: An Ominous Problem Hidden in Plain Sight

    ERIC Educational Resources Information Center

    Dodson, David; Guillory, Ferrel; Lipsitz, Joan; Raper, Noah; Rausch, Christina

    2008-01-01

    In September 2006, the North Carolina GlaxoSmithKline Foundation commissioned MDC, Inc. of Chapel Hill to analyze the problem of "disconnected youth" in the Research Triangle region, determine the current state of the region's responses to the challenge, and recommend steps to deepen and accelerate action on the issue. The research process was…

  10. 78 FR 22270 - Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    .... Rosiglitazone is a thiazolidinedione, indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. AVANDIA is manufactured by GlaxoSmithKline. FDA intends to... readjudication of the Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycemia in...

  11. 77 FR 23288 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... Disk Drive Lab, Secure Talent. ] 81,323 UBS Financial Nashville, TN February 10, 2011. Services, Inc., UBSFS, Wealth Management Americas, WMA Operations, UBS Americas, etc. 81,338 GlaxoSmithKline LLC, East... Estates, IL. Management Corporation, Sears Holding Corporation. 81,268 Follansbee Steel, Follansbee,...

  12. 75 FR 32189 - Joint Meeting of the Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... (rosiglitazone maleate) Tablets, GlaxoSmithKline, a drug approved for blood glucose control in adults with type 2 diabetes mellitus. Data specific to rosiglitazone to be presented will include results from the Rosiglitazone Evaluated for Cardiac Outcome and Regulation of Glycemia in Diabetes (RECORD) Trial,...

  13. Adam Smith and dependency.

    PubMed

    Ozler, Sule

    2012-06-01

    The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing.

  14. Solar Cycle Fine Structure and Surface Rotation from Ca II K-Line Time Series Data

    NASA Technical Reports Server (NTRS)

    Scargle, Jeff; Keil, Steve; Worden, Pete

    2011-01-01

    Analysis of three and a half decades of data from the NSO/AFRL/Sac Peak K-line monitoring program yields evidence for four components to the variation: (a) the solar cycle, with considerable fine structure and a quasi-periodicity of 122.4 days; (b) a stochastic process, faster than (a) and largely independent of it, (c) a quasi-periodic signal due to rotational modulation, and of course (d) observational errors (shown to be quite small). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these chromospheric parameters. Time-frequency analysis is especially useful for extracting information about differential rotation, and in particular elucidates the connection between its behavior and fine structure of the solar cycle on approximately one-year time scales. These results further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced at NASA's Kepler observatory.

  15. Outcome of posterior decompression with instrumented fusion surgery for K-line (-) cervical ossification of the longitudinal ligament.

    PubMed

    Saito, Junya; Maki, Satoshi; Kamiya, Koshiro; Furuya, Takeo; Inada, Taigo; Ota, Mitsutoshi; Iijima, Yasushi; Takahashi, Kazuhisa; Yamazaki, Masashi; Aramomi, Masaaki; Mannoji, Chikato; Koda, Masao

    2016-10-01

    We investigated the outcome of posterior decompression and instrumented fusion (PDF) surgery for patients with K-line (-) ossification of the posterior longitudinal ligament (OPLL) of the cervical spine, who may have a poor surgical prognosis. We retrospectively analyzed the outcome of a series of 27 patients who underwent PDF without correction of cervical alignment for K-line (-) OPLL and were followed-up for at least 1 year after surgery. We had performed double-door laminoplasty followed by posterior instrumented fusion without excessive correction of cervical spine alignment. The preoperative Japanese Orthopedic Association (JOA) score for cervical myelopathy was 8.0 points and postoperative JOA score was 11.9 points on average. The mean JOA score recovery rate was 43.6%. The average C2-C7 angle was 2.2° preoperatively and 3.1° postoperatively. The average maximum occupation ratio of OPLL was 56.7%. In conclusion, PDF without correcting cervical alignment for patients with K-line (-) OPLL showed moderate neurological recovery, which was acceptable considering K-line (-) predicts poor surgical outcomes. Thus, PDF is a surgical option for such patients with OPLL.

  16. Adam Smith on population.

    PubMed

    Spengler, J J

    1970-11-01

    Abstract Adam Smith dealt with questions of population mainly in his Wealth of Nations. His discussion falls roughly under five heads and reflects in considerable measure his image of the English economy. (1) A country's population capacity, given the average level of consumption, was conditioned by the stock of land, the skill with which it was cultivated, and the degree to which division of labour could be increased and thereby augment output for domestic use and sale in external markets. (2) Growth of population was essentially in response to growth of the demand for labour and served to increase division of labour. (3) The social mechanisms underlying elevation of the scale of living are touched upon, and in an optimistic spirit. (4) The distribution of a country's population responded to its progress in opulence, with the rate of this progress conditioned by the degree to which inappropriate (e.g. mercantilist) policies were avoided. (5) Smith dealt briefly with such matters as colonies, education, size of economy, environmental influences, and public policy, all of which he recognized as significant for the quantity and quality of a country's numbers.

  17. Genetics Home Reference: Smith-Magenis syndrome

    MedlinePlus

    ... Understand Genetics Home Health Conditions Smith-Magenis syndrome Smith-Magenis syndrome Enable Javascript to view the expand/ ... boxes. Download PDF Open All Close All Description Smith-Magenis syndrome is a developmental disorder that affects ...

  18. SOLAR CYCLE VARIABILITY AND SURFACE DIFFERENTIAL ROTATION FROM Ca II K-LINE TIME SERIES DATA

    SciTech Connect

    Scargle, Jeffrey D.; Worden, Simon P.; Keil, Stephen L.

    2013-07-01

    Analysis of over 36 yr of time series data from the NSO/AFRL/Sac Peak K-line monitoring program elucidates 5 components of the variation of the 7 measured chromospheric parameters: (a) the solar cycle (period {approx} 11 yr), (b) quasi-periodic variations (periods {approx} 100 days), (c) a broadband stochastic process (wide range of periods), (d) rotational modulation, and (e) random observational errors, independent of (a)-(d). Correlation and power spectrum analyses elucidate periodic and aperiodic variation of these parameters. Time-frequency analysis illuminates periodic and quasi-periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (a) and (b) at timescales in the range {approx}0.1-10 yr. These results using only full-disk data suggest that similar analyses will be useful for detecting and characterizing differential rotation in stars from stellar light curves such as those being produced by NASA's Kepler observatory. Component (c) consists of variations over a range of timescales, in the manner of a 1/f random process with a power-law slope index that varies in a systematic way. A time-dependent Wilson-Bappu effect appears to be present in the solar cycle variations (a), but not in the more rapid variations of the stochastic process (c). Component (d) characterizes differential rotation of the active regions. Component (e) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The data analyzed in this paper can be found at the National Solar Observatory Web site http://nsosp.nso.edu/cak{sub m}on/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

  19. Smith-Magenis syndrome.

    PubMed

    De Leersnyder, H

    2013-01-01

    Smith-Magenis syndrome (SMS) is a mental retardation syndrome with distinctive behavioral characteristics, dysmorphic features, and congenital anomalies ascribed to an interstitial deletion of chromosome 17p11.2. Severe sleep disturbances and maladaptive daytime behavior have been linked to an abnormal circadian rhythm of melatonin with a diurnal instead of nocturnal secretion of this hormone. SMS provides a demonstration of a biological basis for sleep disorder in a genetic disease. Considering that clock genes mediate the generation of circadian rhythm, haploinsufficiency for a circadian system gene, mapping to chromosome 17p11.2, may cause the inversion of the melatonin circadian rhythm in SMS. The disorder of circadian timing in SMS may also affect entrainment pathway (retinohypothalamic tract), pacemaker functions (suprachiasmatic nuclei), or synthesis and release of melatonin by the pineal gland. Elucidating pathophysiological mechanisms of behavioral phenotypes in genetic disease can provide an original therapeutic approach in SMS: blockade of endogenous melatonin production during the day combined with exogenous melatonin administration in the evening.

  20. Smith-Magenis syndrome.

    PubMed

    Elsea, Sarah H; Girirajan, Santhosh

    2008-04-01

    Smith-Magenis syndrome (SMS) is a complex neurobehavioral disorder caused by haploinsufficiency of the retinoic acid-induced 1 (RAI1) gene on chromosome 17p11.2. Diagnostic strategies include molecular identification of a 17p11.2 microdeletion encompassing RAI1 or a mutation in RAI1. G-banding and fluorescent in situ hybridization (FISH) are the classical methods used to detect the SMS deletions, while multiplex ligation-dependent probe amplification (MLPA) and real-time quantitative PCR are the newer, cost-effective, and high-throughput technologies. Most SMS features are due to RAI1 haploinsufficiency, while the variability and severity of the disorder are modified by other genes in the 17p11.2 region. The functional role for RAI1 is not completely understood, but it is likely involved in transcription, based on homology and preliminary studies. Management of SMS is primarily a multidisciplinary approach and involves treatment for sleep disturbance, speech and occupational therapies, minor medical interventions, and management of behaviors.

  1. Smith heads Reviews of Geophysics

    NASA Astrophysics Data System (ADS)

    On January 1, Jim Smith began his term as editor-in-chief of Reviews of Geophysics. As editor-in-chief, he leads the board of editors in enhancing the journal's role as an integrating force in the geophysical sciences by providing timely overviews of current research and its trends. Smith is already beginning to fulfill the journal's role of providing review papers on topics of broad interest to Union members as well as the occasional definitive review paper on selected topics of narrower focus. Smith will lead the editorial board until December 31, 2000. Michael Coffey, Tommy Dickey, James Horwitz, Roelof Snieder, and Thomas Torgersen have been appointed as editors to serve with Smith. At least one more editor will be named to round out the disciplinary expertise on the board.

  2. Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats

    PubMed Central

    Ari, Csilla; Kovács, Zsolt; Juhasz, Gabor; Murdun, Cem; Goldhagen, Craig R.; Koutnik, Andrew P.; Poff, Angela M.; Kesl, Shannon L.; D’Agostino, Dominic P.

    2016-01-01

    Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We tested exogenous ketone supplements added to food and fed chronically for 83 days in SPD rats and administered sub-chronically for 7 days in both rat models by daily intragastric gavage bolus followed by assessment of anxiety measures on elevated plus maze (EPM). The groups included standard diet (SD) or SD + ketone supplementation. Low-dose ketone ester (LKE; 1,3-butanediol-acetoacetate diester, ~10 g/kg/day, LKE), high dose ketone ester (HKE; ~25 g/kg/day, HKE), beta-hydroxybutyrate-mineral salt (βHB-S; ~25 g/kg/day, KS) and βHB-S + medium chain triglyceride (MCT; ~25 g/kg/day, KSMCT) were used as ketone supplementation for chronic administration. To extend our results, exogenous ketone supplements were also tested sub-chronically on SPD rats (KE, KS and KSMCT; 5 g/kg/day) and on WAG/Rij rats (KE, KS and KSMCT; 2.5 g/kg/day). At the end of treatments behavioral data collection was conducted manually by a blinded observer and with a video-tracking system, after which blood βHB and glucose levels were measured. Ketone supplementation reduced anxiety on EPM as measured by less entries to closed arms (sub-chronic KE and KS: SPD rats and KSMCT: WAG/Rij rats), more time spent in open arms (sub-chronic KE: SPD and KSMCT: WAG/Rij rats; chronic KSMCT: SPD rats), more distance traveled in open arms (chronic KS and KSMCT: SPD rats) and by delayed latency to entrance to closed arms (chronic KSMCT: SPD rats), when compared to control. Our data indicates that chronic and sub-chronic ketone supplementation not only elevated blood βHB levels in both animal models, but reduced anxiety-related behavior. We conclude that ketone supplementation may represent a promising anxiolytic strategy through a

  3. Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.

    PubMed

    Lakatos, Renáta Krisztina; Dobolyi, Árpád; Todorov, Mihail Ivilinov; Kékesi, Katalin A; Juhász, Gábor; Aleksza, Magdolna; Kovács, Zsolt

    2016-06-01

    The non-adenosine nucleoside guanosine (Guo) was demonstrated to decrease quinolinic acid(QA)-induced seizures, spontaneously emerged absence epileptic seizures and lipopolysaccharide(LPS)-evoked induction of absence epileptic seizures suggesting its antiepileptic potential. It was also described previously that intraperitoneal (i.p.) injection of 20 and 50mg/kg Guo decreased the number of spike-wave discharges (SWDs) in a well investigated model of human absence epilepsy, the Wistar Albino Glaxo Rijswijk (WAG/Rij) rats during 4th (20mg/kg Guo) and 3rd as well as 4th (50mg/kg Guo) measuring hours. Guanosine can potentially decrease SWD number by means of its putative receptors but absence epileptic activity changing effects of Guo by means of increased extracellular adenosine (Ado) cannot be excluded. An increase in the dose of i.p. injected Guo is limited by its low solubility in saline, therefore, we addressed in the present study whether higher doses of Guo, diluted in sodium hydroxide (NaOH) solution, have more potent antiepileptic effect in WAG/Rij rats. We confirmed that i.p. 50mg/kg Guo decreased but, surprisingly, i.p. 100mg/kg Guo enhanced the number of SWDs in WAG/Rij rats. Combined i.p. injection of a non-selective Ado receptor antagonist theophylline (5mg/kg) or a selective Ado A2A receptor (A2AR) antagonist SCH 58261 (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine) (1mg/kg) and a cyclooxygenase 1 and 2/COX-1 and COX-2 inhibitor indomethacin (10mg/kg) with 100mg/kg Guo decreased the SWD number compared to i.p. 100mg/kg Guo alone. The results suggest that i.p. 100mg/kg Guo can increase SWD number by means of the adenosinergic system.

  4. Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.

    PubMed

    Ari, Csilla; Kovács, Zsolt; Juhasz, Gabor; Murdun, Cem; Goldhagen, Craig R; Koutnik, Andrew P; Poff, Angela M; Kesl, Shannon L; D'Agostino, Dominic P

    2016-01-01

    Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders. The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We tested exogenous ketone supplements added to food and fed chronically for 83 days in SPD rats and administered sub-chronically for 7 days in both rat models by daily intragastric gavage bolus followed by assessment of anxiety measures on elevated plus maze (EPM). The groups included standard diet (SD) or SD + ketone supplementation. Low-dose ketone ester (LKE; 1,3-butanediol-acetoacetate diester, ~10 g/kg/day, LKE), high dose ketone ester (HKE; ~25 g/kg/day, HKE), beta-hydroxybutyrate-mineral salt (βHB-S; ~25 g/kg/day, KS) and βHB-S + medium chain triglyceride (MCT; ~25 g/kg/day, KSMCT) were used as ketone supplementation for chronic administration. To extend our results, exogenous ketone supplements were also tested sub-chronically on SPD rats (KE, KS and KSMCT; 5 g/kg/day) and on WAG/Rij rats (KE, KS and KSMCT; 2.5 g/kg/day). At the end of treatments behavioral data collection was conducted manually by a blinded observer and with a video-tracking system, after which blood βHB and glucose levels were measured. Ketone supplementation reduced anxiety on EPM as measured by less entries to closed arms (sub-chronic KE and KS: SPD rats and KSMCT: WAG/Rij rats), more time spent in open arms (sub-chronic KE: SPD and KSMCT: WAG/Rij rats; chronic KSMCT: SPD rats), more distance traveled in open arms (chronic KS and KSMCT: SPD rats) and by delayed latency to entrance to closed arms (chronic KSMCT: SPD rats), when compared to control. Our data indicates that chronic and sub-chronic ketone supplementation not only elevated blood βHB levels in both animal models, but reduced anxiety-related behavior. We conclude that ketone supplementation may represent a promising anxiolytic strategy through a

  5. An industry update: what is new in the field of therapeutic delivery this month?

    PubMed

    Harris, Elaine

    2017-01-01

    The present industry update covers the period of 1-30 November 2016, with information sourced primarily from company press releases, regulatory and patent agencies, scientific literature and various news websites. There was positive news on the clinical trials front for both EyeNovia and Glaxo SmithKline, but this month also saw Innocol release disappointing Phase IIb results for its Cogenzia product. In regulatory news, it was announced that the US FDA indicated that EyeGate may use the 510(k) De Novo Path for their device, the Ocular Bandage Gel. Also this month, Glaxo SmithKline announced that it filed a regulatory submission with the FDA for its novel triple-combination therapy product, utilizing its Ellipta(®) inhaler.

  6. 28th Annual JPMorgan Healthcare Conference--Human Genome Sciences and Celgene.

    PubMed

    Gale, Sophie; Croasdell, Gary

    2010-03-01

    The JPMorgan Healthcare Conference, held in San Francisco, included presentations by various pharmaceutical companies summarizing their achievements in 2009 and expectations for 2010. This conference report highlights presentations from Human Genome Sciences Inc and Celgene Corp. Investigational drugs from Human Genome Sciences, including belimumab (in collaboration with GlaxoSmithKline plc), albinterferon alfa-2b (with Novartis AG), mapatumumab (with Takeda Pharmaceutical Co Ltd) and HGS-1029, and from Celgene, including romidepsin, pomalidomide, apremilast and PDA-001 (Celgene Cellular Therapeutics), are discussed.

  7. Foundation for Integrating Employee Health Activities for Active Duty Personnel in the Department of Defense

    DTIC Science & Technology

    2009-01-01

    academic and trade literatures. In addi- tion to J&J and FedEx, other prominent companies pursuing this approach are Dow Chemi- cal, Citibank ...Awareness Campaigns Onsite Program Personalized Intervention Reassessments Citibank (Goetzel, 2005) √ √ √ Daimler-Chrysler (Serxner, Gold, et al...Incentives Continuous Evaluation Citibank (Goetzel, 2005) √ Daimler-Chrysler (Serxner, Gold, et al., 2003) √ √ GlaxoSmithKline (Stave, Muchmore

  8. Investor Outlook: Rising from the Ashes; GSK's European Approval of Strimvelis for ADA-SCID.

    PubMed

    Schimmer, Joshua; Breazzano, Steven

    2016-06-01

    GlaxoSmithKline's (GSK) and partner San Raffaele Telethon Institute for Gene Therapy's recent positive European approval for Strimvelis for treatment of severe combined immunodeficiency due to adenosine deaminase deficiency (ADA-SCID) represents the second EU-approved gene therapy and the first γ-retrovirus and first ex vivo gene therapy. In this article we discuss the significance and implications of this historic approval for the broader gene therapy field.

  9. International Drug Discovery Science and Technology--BIT's Seventh Annual Congress.

    PubMed

    Bodovitz, Steven

    2010-01-01

    BIT's Seventh Annual International Drug Discovery Science and Technology Congress, held in Shanghai, included topics covering new therapeutic and technological developments in the field of drug discovery. This conference report highlights selected presentations on open-access approaches to R&D, novel and multifactorial targets, and technologies that assist drug discovery. Investigational drugs discussed include the anticancer agents astuprotimut-r (GlaxoSmithKline plc) and AS-1411 (Antisoma plc).

  10. An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS.

    PubMed

    Calderón, Félix; Barros, David; Bueno, José María; Coterón, José Miguel; Fernández, Esther; Gamo, Francisco Javier; Lavandera, José Luís; León, María Luisa; Macdonald, Simon J F; Mallo, Araceli; Manzano, Pilar; Porras, Esther; Fiandor, José María; Castro, Julia

    2011-10-13

    In 2010, GlaxoSmithKline published the structures of 13533 chemical starting points for antimalarial lead identification. By using an agglomerative structural clustering technique followed by computational filters such as antimalarial activity, physicochemical properties, and dissimilarity to known antimalarial structures, we have identified 47 starting points for lead optimization. Their structures are provided. We invite potential collaborators to work with us to discover new clinical candidates.

  11. Belimumab: anti-BLyS monoclonal antibody; Benlysta; BmAb; LymphoStat-B.

    PubMed

    2010-01-01

    Belimumab is a fully human monoclonal antibody for the treatment of autoimmune disorders that is being developed by Human Genome Sciences and GlaxoSmithKline. Two pivotal phase III trials in systemic lupus erythematosus have been concluded with the primary endpoints being met in both studies. A phase II trial in rheumatoid arthritis has also been completed, with positive results. Marketing authorization submissions are being prepared in the major markets worldwide. This review discusses the development history and scientific profile of belimumab.

  12. Fourth Medical Biotech Forum of the Chinese Medical Biotech Association. 8-10 August 2009, Dalian, China.

    PubMed

    Felzmann, Thomas

    2009-10-01

    The Chinese Medical Biotech Association's Fourth Medical Biotech Forum held in Dalian, China included topics covering the biotechnology industry in China and new therapeutic developments in the field of immunological approaches to cancer treatment. This conference report highlights selected presentations on China's biotechnology development policy, tumor-specific antigens, clinical applications of antitumor immune therapy, and novel photodynamic tumor therapy. Investigational therapeutics discussed include astuprotimut-r (GlaxoSmithKline plc) and the dendritic cell vaccine Trivax (Trimed Biotech).

  13. FDA Approves Two HPV Vaccines: Cervarix for Girls, Gardasil for Boys | Division of Cancer Prevention

    Cancer.gov

    The FDA has approved a second vaccine to prevent cervical cancer and cervical precancers, the vaccine’s manufacturer, GlaxoSmithKline (GSK), announced last week. The approval is based on data from a large clinical trial showing that the vaccine, Cervarix, prevented precancerous lesions in 93 percent of those who received the full vaccine sequence of three injections over 6 months. |

  14. Arthur Smith, Local Baptist Pastor.

    ERIC Educational Resources Information Center

    Heaton, Moss, Ed.

    1985-01-01

    Written and published by the students at Gary High School this volume has three articles dealing with East Texas life. The first "Arthur Smith" (David Hancock and others) is an account of growing up in Marian County, Texas is described by the local Baptist minister. The pastor begins with the year of his birth and gives detailed…

  15. Near-coincident K-line and K-edge energies as ionization diagnostics for some high atomic number plasmas

    SciTech Connect

    Pereira, N. R.; Weber, B. V.; Phipps, D. G.; Schumer, J. W.; Seely, J. F.; Carroll, J. J.; Vanhoy, J. R.; Slabkowska, K.; Polasik, M.

    2012-10-15

    For some high atomic number atoms, the energy of the K-edge is tens of eVs higher than the K-line energy of another atom, so that a few eV increase in the line's energy results in a decreasing transmission of the x-ray through a filter of the matching material. The transmission of cold iridium's Asymptotically-Equal-To 63.287 keV K{alpha}{sub 2} line through a lutetium filter is 7% lower when emitted by ionized iridium, consistent with an energy increase of {Delta}{epsilon} Asymptotically-Equal-To 10{+-}1 eV associated with the ionization. Likewise, the transmission of the K{beta}{sub 1} line of ytterbium through a near-coincident K-edge filter changes depending on plasma parameters that should affect the ionization. Systematic exploration of filter-line pairs like these could become a unique tool for diagnostics of suitable high energy density plasmas.

  16. Cecil Green receives Smith Medal

    NASA Astrophysics Data System (ADS)

    Press, Frank; Green, Cecil

    The Waldo E. Smith Medal, which is awarded for extraordinary service to geophysics, was presented to Cecil H. Green at the 1994 AGU Fall Meeting Honors Ceremony on December 7, 1994 in San Francisco. The award citation and Green's response are given here.“It would take a book to do justice to Cecil Green's extraordinary contributions to the geophysics and electronics industries, to the training of scientists, physicians, and engineers, and to strengthening education and research institutions. In fact, such a book has been written about Cecil's multiple lives as engineer, geophysicist, cofounder of Texas Instruments, and partner with his wife, Ida, in international philanthropy.

  17. Bringing Sally Smith's Vision to Manayunk

    ERIC Educational Resources Information Center

    Ford, Jackie

    2010-01-01

    In this article, the author narrates her application of what she learned from her internship at Sally Smith's Lab School of Washington to her new school and shares the favorable impact it had brought on her teaching career. The author shares her first exposure to the powerful effects of Smith's "Live It, Learn It" methodology as she…

  18. Guide to the Logan Pearsall Smith Collection.

    ERIC Educational Resources Information Center

    Pettit, Katherine Denshaw

    A guide to the Logan Pearsall Smith Collection at Trinity University Elizabeth Coates Maddux Library in San Antonio, Texas provides a descriptive overview of the collected works of this renowned epigrammatist, critic, essayist, biographer, and authority on the English language. The guide includes a brief biography of Smith (1865-1946), detailed…

  19. 33 CFR 117.841 - Smith Creek.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Smith Creek. 117.841 Section 117.841 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements North Carolina § 117.841 Smith Creek. The draw of the...

  20. Adam Smith and the Rhetoric of Style.

    ERIC Educational Resources Information Center

    Moran, Michael G.

    Historians of rhetoric have generally accepted the view that Adam Smith rejected the principles of classical rhetoric. However, while there can be no doubt that Smith greatly truncated the five classical arts of rhetoric (invention, arrangement, style, memory, and delivery) by reducing his concerns largely to style and arrangement, he did not…

  1. The Treatment of Smith's Invisible Hand

    ERIC Educational Resources Information Center

    Wight, Jonathan B.

    2007-01-01

    Adam Smith used the metaphor of an invisible hand to represent the instincts of human nature that direct behavior. Moderated by self-control and guided by proper institutional incentives, actions grounded in instincts can be shown to generate a beneficial social order even if not intended. Smith's concept, however, has been diluted and distorted…

  2. Environmental assessment: Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and the eight other potentially sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of the five sites suitable for characterization. 591 refs., 147 figs., 173 tabs.

  3. Genetics Home Reference: Smith-Lemli-Opitz syndrome

    MedlinePlus

    ... Genetics Home Health Conditions Smith-Lemli-Opitz syndrome Smith-Lemli-Opitz syndrome Enable Javascript to view the ... boxes. Download PDF Open All Close All Description Smith-Lemli-Opitz syndrome is a developmental disorder that ...

  4. Smith-Lemli-Opitz Syndrome

    PubMed Central

    DeBarber, Andrea E.; Eroglu, Yasemen; Merkens, Louise S.; Pappu, Anuradha S.; Steiner, Robert D.

    2012-01-01

    Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital malformation/intellectual disability syndrome, with clinical characteristics encompassing a wide spectrum and great variability. Elucidation of the biochemical and molecular genetic basis for the autosomal recessively inherited SLOS, specifically, understanding SLOS as a cholesterol deficiency syndrome caused by mutations in DHCR7, opened up enormous possibilities for therapeutic intervention. When cholesterol was discovered to be the activator of sonic hedgehog, cholesterol deficiency with inactivation of this developmental patterning gene was thought to be the cause of SLOS malformations, yet this explanation is overly simplistic. Still, despite these important research breakthroughs, there is no proven treatment for SLOS. Better animal models are needed to allow potential treatment testing and the study of disease pathophysiology, which is incompletely understood. Creation of human cellular models will surely be useful, especially models of brain cells. In vivo human studies are essential as well. There have only been limited natural history studies of SLOS to date. Biomarker development will be critical in facilitating clinical trials in this rare condition, since clinical phenotype may change over many years. Additional research in these and other areas is critical if we are to make headway towards ameloriating the effects of this devastating condition. PMID:21777499

  5. A comparison between two hydrothermally formed extensional environment related kaolin deposits: Balikesir-Duvertepe, Turkey and Kline Mountain, Sierra County, New Mexico

    SciTech Connect

    Isik, I.; Clark, K.F. . Dept. of Geological Sciences)

    1992-01-01

    Economically important and hydrothermally formed kaolin deposits are often found within rift lithologic units, formed as a result of interaction of physical and geochemical processes in the extensional environment. The kaolin deposits of Balikesir--Duvertepe, Turkey and Kline Mountain, Sierra County, New Mexico, studied herein, are examples of this type. The Balikesir--Duvertepe district has been known as the most productive kaolin district in Turkey. Total reserves are estimated at 15 million metric tons. Located in the active Simav Graben produced by the subduction of the African Plate under the Aegean region, the kaolin deposits occur irregularly and variably in quality as a result of hydrothermal alteration of Neogene tuffs. The Kline Mountain kaolin deposit was formed as a result of advanced argillic alteration on the southeastern edge of the Mogollon--Datil volcanic field, which is related to the extensional environment of Basin and Range province and the Rio Grande rift. Its reserve is reported as 200 million metric tons of altered tuffs. The two deposits show striking similarities: extensional related rock units, intense in situ hydrothermal alteration, mineral content, seismic activity, alunite contamination, chemical composition, and intense silicification. The deposits also display some differences: regional climate, the intensity of hydrothermal alteration and the elapsed time causing relatively complete replacement in the Turkish deposit compared to that in NM. The Balikesir--Duvertepe district has been the center of kaolin marketing for use chiefly in ceramic, paper, and white cement, while the Kline Mountain kaolin had been exploited primarily for paper and ceramic tile as a coating; and in the oil industry as a filler and absorbent material.

  6. Environmental assessment, Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    The Nuclear Waste Policy Act of 1982 (42 USC sections 10101-10226) requires the environmental assessment of a proposed site to include a statement of the basis for nominating a site as suitable for characterization. Volume 2 provides a detailed statement evaluating the site suitability of the Deaf Smith County Site under DOE siting guidelines, as well as a comparison of the Deaf Smith County Site to the other sites under consideration. The evaluation of the Deaf Smith County Site is based on the impacts associated with the reference repository design, but the evaluation will not change if based on the Mission Plan repository concept. The second part of this document compares the Deaf Smith County Site to Davis Canyon, Hanford, Richton Dome and Yucca Mountain. This comparison is required under DOE guidelines and is not intended to directly support subsequent recommendation of three sites for characterization as candidate sites. 259 refs., 29 figs., 66 refs. (MHB)

  7. Environmental assessment: Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of the nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines.

  8. Evaluation of effects of T and N type calcium channel blockers on the electroencephalogram recordings in Wistar Albino Glaxo/Rij rats, an absence epilepsy model

    PubMed Central

    Durmus, Nedim; Gültürk, Sefa; Kaya, Tijen; Demir, Tuncer; Parlak, Mesut; Altun, Ahmet

    2015-01-01

    Objectives: It is suggested that excessive calcium entry into neurons is the main triggering event in the initiation of epileptic discharges. We aimed to investigate the role of T and N type calcium channels in absence epilepsy experimental model. Materials and Methods: Wistar Albino Glaxo/Rij (WAG/Rij) rats (12–16 weeks old) were randomly allocated into four groups; sham, mibefradil (T type calcium channel blocker), w-Conotoxin MVIIA (N type calcium channel blocker), and mibefradil + w-Conotoxin MVIIA. Beta, alpha, theta, and delta wave ratios of EEG recordings and frequency and duration of spike wave discharges (SWDs) were analyzed and compared between groups. Results: Beta and delta recording ratios in 1 μM/5 μl mibefradil group was significantly different from basal and other dose-injected groups. Beta, alpha, and theta recordings in 0.2 μM/5 μl w-Conotoxin MVIIA group was significantly different from basal and other dose-injected groups. In w-Conotoxin MVIIA after mibefradil group, beta, alpha, and theta recording ratios were significantly different from basal and mibefradil group. Mibefradil and w-Conotoxin MVIIA significantly decreased the frequency and duration of SWDs. The decrease of frequency and duration of SWDs in mibefradil group was significantly different from w-Conotoxin MVIIA group. The frequency and duration of SWDs significantly decreased in w-Conotoxin MVIIA after mibefradil group compared with basal, mibefradil, and w-Conotoxin MVIIA groups. Conclusions: We concluded that both T and L type calcium channels play activator roles in SWDs and have positive effects on frequency and duration of these discharges. These results are related with their central effects more than peripheral effects. PMID:25821308

  9. The Devil in Mr. Smith: A Conversation with Jonathan Z. Smith

    ERIC Educational Resources Information Center

    Smith, Jonathan Z.; Pearson, Thomas; Gallagher, Eugene V.; Jensen, Tim; Fujiwara, Satoko

    2014-01-01

    This interview was recorded in November 2012 in Jonathan Z. Smith's Hyde Park graystone. Professor Smith offers insights into how he thinks about his classroom teaching and his students' learning through descriptions of various assignments and classroom activities he has developed over more than forty years of teaching. The discussion…

  10. STS-110 Crew Interviews: Steve Smith

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-110 Mission Specialist Steve Smith is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Smith outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the payload (S0 Truss and Mobile Transporter) and the dry run installation of the S0 truss that will take place the day before the EVA for the actual installation. Smith discusses the planned EVAs in detail and outlines what supplies will be left for the resident crew of the International Space Station (ISS). He ends with his thoughts on the most valuable aspect of the ISS.

  11. STS-103 Crew Interviews: Steven Smith

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Live footage of a preflight interview with Mission Specialist Steven L. Smith is seen. The interview addresses many different questions including why Brown became an astronaut, the events that led to his interest, any role models that he had, and his inspiration. Other interesting information that this one-on-one interview discusses is an explanation of the why this required mission to service the Hubble Space Telescope must take place at such an early date, replacement of the gyroscopes, transistors, and computers. Also discussed is Smith's responsibility during any of the planned space walks scheduled for this mission.

  12. Smith-Magenis Syndrome: Face Speaks.

    PubMed

    Gupta, Rekha; Gupta, Neerja; Nampoothiri, Sheela; Mandal, Kausik; Kishore, Yougal; Sharma, Pankaj; Kabra, Madhulika; Phadke, Shubha R

    2016-06-01

    Smith-Magenis syndrome is a well delineated microdeletion syndrome with characteristic facial and behavioral phenotype. With the availability of the multi-targeted molecular cytogenetic techniques like Multiplex Ligation Probe Amplification and cytogenetic microarray, the cases are diagnosed even without clinical suspicion. Here, the authors present clinical features of nine Indian cases of Smith-Magenis syndrome. Characteristic facial phenotype including tented upper lip, broad forehead, midface hypoplasia, short philtrum and upslant of palpebral fissure is obvious in the photographs. The behavioral variations were seen in some of the cases but were not the presenting features. The characteristic facial phenotype can be an important clinical guide to the diagnosis.

  13. Dialogues with Marilyn Cochran-Smith

    ERIC Educational Resources Information Center

    Fiorentini, Dario; Crecci, Vanessa Moreira

    2015-01-01

    For more than 30 years, Dr. Marilyn Cochran-Smith has developed and directed research and contributed to publications about education and "practitioner research," especially about teachers' research and learning in inquiry communities. Her primary topics are inquiry communities, teacher research, teacher education for social…

  14. Another Perspective: An Interview with David Smith

    ERIC Educational Resources Information Center

    Bowman, Ruth A.; Johnson, Kelli

    2005-01-01

    To provide another perspective on evaluation within nonformal settings, "New Directions for Evaluation" recently interviewed David Smith, the coordinator of the Professional Learning to Close the Achievement Gap program for the Kansas City, Kansas, Public Schools, who has extensive background in education and educational research. He formerly held…

  15. Adam Smith, Religion, and Tuition Tax Credits.

    ERIC Educational Resources Information Center

    Alexander, Kern

    1983-01-01

    Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

  16. For the Health of Smith Island.

    ERIC Educational Resources Information Center

    Forsthoffer, Joe

    1997-01-01

    Students in nursing, allied health, social work, and medicine at the University of Maryland are offered clinical experiences on Smith Island in Chesapeake Bay. The program exposes them to the special health care needs and problems of an isolated, economically disadvantaged, rural community. (SK)

  17. Dialogue of Differences: The Writing of Henry Holmes Smith.

    ERIC Educational Resources Information Center

    Bossen, Howard

    In addition to surveying the writings of Henry Holmes Smith, this paper explains his importance as a theoretician and practitioner of photography. After a discussion of Smith's ideas on "reading photographs" and his concerns with the ethics of photography, particularly of photojournalism, the essays in the book, "Henry Holmes Smith:…

  18. SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SMITH FARM FROM CEMETERY HILL, LOOKING SOUTHWEST. (This image shows the Smith Farm in the center of Ebey’s Prairie. Ebey’s Landing and the Puget Sound can be seen on the right. Farmers from the Sherman-Bishop Dairy are visible at the bottom left, cutting hay.) - Smith Farm, 399 Ebey Road, Coupeville, Island County, WA

  19. The genetics of a pharma merger.

    PubMed

    Sanseau, Philippe; Chabot-Fletcher, Marie; Browne, Michael J

    2009-04-01

    The 1990s and early years of this century have seen a series of large-scale mergers and acquisitions in the Pharmaceutical and Biotech arena. These activities each required integration at multiple levels. One of the most important activities is the integration of the R&D pipelines of the participants. We outline the combined portfolio and bioinformatic strategy that was used, and detail the lessons learned for the longer term, from the GlaxoWellcome-SmithKline-Beecham merger in 2000. To date, this has been the largest merger of two equally sized Pharma R&D organisations.

  20. Retapamulin for impetigo and other infections.

    PubMed

    2008-10-01

    Last year, we concluded that topical fusidic acid should be first-line treatment for impetigo. Since then, retapamulin ointment (Altargo - GlaxoSmithKline), a new antibacterial, has been licensed in the European Union as a short-term treatment for impetigo and infected small lacerations, abrasions or sutured wounds in people aged 9 months or above. Advertisements claim that the product "treats localised impetigo in just 5 days"; by comparison, the British National Formulary (BNF) advises a 7-day course of fusidic acid. Here we consider the place of retapamulin in impetigo and its other licensed indications.

  1. The Smith-Lemli-Opitz syndrome

    PubMed Central

    Kelley, R.; Hennekam, R.

    2000-01-01

    The Smith-Lemli-Opitz syndrome (SLOS) is one of the archetypical multiple congenital malformation syndromes. The recent discovery of the biochemical cause of SLOS and the subsequent redefinition of SLOS as an inborn error of cholesterol metabolism have led to important new treatment possibilities for affected patients. Moreover, the recent recognition of the important role of cholesterol in vertebrate embryogenesis, especially with regard to the hedgehog embryonic signalling pathway and its effects on the expression of homeobox genes, has provided an explanation for the abnormal morphogenesis in the syndrome. The well known role of cholesterol in the formation of steroid hormones has also provided a possible explanation for the abnormal behavioural characteristics of SLOS.


Keywords: Smith-Lemli-Opitz syndrome; cholesterol metabolism; 7-dehydrocholesterol reductase; clinical history; management PMID:10807690

  2. Stable LPV realisation of the Smith predictor

    NASA Astrophysics Data System (ADS)

    Blanchini, Franco; Casagrande, Daniele; Miani, Stefano; Viaro, Umberto

    2016-07-01

    The paper is concerned with the control of a linear plant with an output delay. As is known, when the plant parameters do not vary in time, the transfer function approach can be used to find a high-performing controller with the Smith-predictor structure. Such an approach in the domain of the Laplace transform is not directly applicable in the time-variant case. Nevertheless, it is shown that the transfer function of the Smith controller valid for constant values of the parameters can be realised in such a way that closed-loop stability, as well as point-wise optimal performance, is ensured also when the parameters vary with time. The suggested technique is applied to the control of a heat exchanger whose varying parameters include a measurement delay.

  3. Smith Newton Vehicle Performance Evaluation (Brochure)

    SciTech Connect

    Not Available

    2012-08-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. Through this project, Smith Electric Vehicles will build and deploy 500 all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

  4. Roger E. Smith: 1986 Horton Award Recipient

    NASA Astrophysics Data System (ADS)

    Johnson, A. Ivan; Smith, Roger E.

    The recipient of the 1986 Robert T. Horton Award is Roger E. Smith. Roger received his bachelor's degree in civil engineering from Texas Technical University at Lubbock, Tex., in 1963, and his master's degree in civil engineering from Stanford University at Stanford, Calif., in 1964. Roger then spent 2 years in the Peace Corps Service in Pakistan. In 1967, he enrolled as a graduate student at Colorado State University.

  5. Smith-Purcell free-electron laser

    SciTech Connect

    Woods, K.J.; Walsh, J.E.

    1995-12-31

    The term Smith-Purcell free electron laser can be employed generally to describe any coherent radiation source in which a diffraction grating is used to couple an electron beam with the electromagnetic field. To date, most practical developments of this concept have focused on devices which operate in the millimeter spectral regime. In this paper construction of a Smith-Purcell free-electron laser operating in the far-infrared (FIR) region using a novel resonator cavity design and the electron beam from a low energy (0.5-5 MeV) radio-frequency accelerator will be discussed. A tunable source in this region would have many applications and since the beam energy is low, the small size and low overall cost of such a device would make it a laboratory instrument. Current projects which are progressing towards developing a FIR source are the programs at Stanford and CREOL. Both of these projects are using permanent magnet undulators to couple the electron beam with the electromagnetic field. An alternative approach is to use an electron beam passing over a diffraction grating as the radiating mechanism. This phenomenon is known as Smith-Purcell radiation and was first demonstrated for incoherent emission at visible wavelengths. The addition of feedback enhances the stimulated component of the emission which leads to the growth of coherence. Recent calculations for spontaneous emission have shown that the wiggler parameter and the grating efficiency are analogous. This result has important implications for the development of a Smith-Purcell FEL because a grating based free-electron laser would offer a greater range of tunability at a lower cost than its wiggler based counterpart.

  6. Processing Semblances Induced through Inter-Postsynaptic Functional LINKs, Presumed Biological Parallels of K-Lines Proposed for Building Artificial Intelligence.

    PubMed

    Vadakkan, Kunjumon I

    2011-01-01

    The internal sensation of memory, which is available only to the owner of an individual nervous system, is difficult to analyze for its basic elements of operation. We hypothesize that associative learning induces the formation of functional LINK between the postsynapses. During memory retrieval, the activation of either postsynapse re-activates the functional LINK evoking a semblance of sensory activity arriving at its opposite postsynapse, nature of which defines the basic unit of internal sensation - namely, the semblion. In neuronal networks that undergo continuous oscillatory activity at certain levels of their organization re-activation of functional LINKs is expected to induce semblions, enabling the system to continuously learn, self-organize, and demonstrate instantiation, features that can be utilized for developing artificial intelligence (AI). This paper also explains suitability of the inter-postsynaptic functional LINKs to meet the expectations of Minsky's K-lines, basic elements of a memory theory generated to develop AI and methods to replicate semblances outside the nervous system.

  7. Processing Semblances Induced through Inter-Postsynaptic Functional LINKs, Presumed Biological Parallels of K-Lines Proposed for Building Artificial Intelligence

    PubMed Central

    Vadakkan, Kunjumon I.

    2011-01-01

    The internal sensation of memory, which is available only to the owner of an individual nervous system, is difficult to analyze for its basic elements of operation. We hypothesize that associative learning induces the formation of functional LINK between the postsynapses. During memory retrieval, the activation of either postsynapse re-activates the functional LINK evoking a semblance of sensory activity arriving at its opposite postsynapse, nature of which defines the basic unit of internal sensation – namely, the semblion. In neuronal networks that undergo continuous oscillatory activity at certain levels of their organization re-activation of functional LINKs is expected to induce semblions, enabling the system to continuously learn, self-organize, and demonstrate instantiation, features that can be utilized for developing artificial intelligence (AI). This paper also explains suitability of the inter-postsynaptic functional LINKs to meet the expectations of Minsky’s K-lines, basic elements of a memory theory generated to develop AI and methods to replicate semblances outside the nervous system. PMID:21845180

  8. Breeding productivity of Smith Island black ducks

    USGS Publications Warehouse

    Haramis, G.M.; Jorde, D.G.; Olsen, G.H.; Stotts, D.B.; Harrison, M.K.; Perry, M.C.

    2002-01-01

    We investigated the breeding performance of American black ducks (Anas rubripes) on Smith Island, Chesapeake Bay, to improve our understanding of island black duck breeding ecology and to make management recommendations to enhance productivity. During 1995-96, we implanted 56 female black ducks with 20-g radio transmitters and tracked 35 of the individuals through the breeding season to locate nests, determine nest fate, and identify brood habitat. We also increased preseason banding efforts and compared capture characteristics over 12 years with those from the Deal Island Wildlife Management Area, a banding site on the mainland of Tangier Sound. A low rate of nesting (37%), lack of renesting, and poor hatching success (31%) indicated that island salt marsh habitats present a harsh environment for breeding black ducks. Black ducks located 11 of 13 nests (85%) in black needlerush (Juncus roemerianus) marsh where they were vulnerable to flooding from extreme tides and to egg predators. No nests were found on forested tree hammocks, a feature that distinguishes Smith Island from nearby South Marsh and Bloodsworth Islands. Nest predators included red foxes (Vulpes vulpes), herring gulls (Larus argentams), fish crows (Corvus ossifragus), and, potentially, Norway rats (Rattus norvegicus). Unlike mainland red foxes, foxes radio tracked on Smith Island were found to be capable swimmers and effective low marsh predators. We found shoreline meadows of widgeon grass (Ruppia maritima) to be important foraging sites for black ducks and suspected that the virtual absence of fresh water in this high salinity environment (1217+ ppt) to incur some cost in terms of growth and survival of ducklings. Preseason bandings revealed a high proportion of banded adults and a strong positive correlation in age ratios with the Deal Island banding site. This latter finding strongly suggests a negative universal effect of storm tides on nest success for Tangier Sound black ducks. Management to

  9. Smith Newton Vehicle Performance Evaluation - Cumulative (Brochure)

    SciTech Connect

    Not Available

    2014-08-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  10. 60% Review technical specifications, Deaf Smith Site

    SciTech Connect

    Gast, R.A.

    1987-08-01

    The enclosed documentation for the 60% Review Technical Specifications, Deaf Smith Site includes: Solicitation Documents which represent the eventual Federal Acquisition Regulations (FARs) and Department of Energy Acquisition Regulations (DEARs) that will comprise a segment of the contractual documents for bidders attention; Contract Clauses that will become integral parts for the Fixed Price Construction Contracts applicable to the Exploratory Shaft Facility; Special Contract Requirements that will become contract provisions requiring specific contractor attention; Technical Specifications which have been completed for 60% submission, and the current list of 241 Contract Drawings that have been separately forwarded for review and comment.

  11. 77 FR 13593 - PowerSmith Cogeneration Project, LP; Notice of Request for Waiver

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... Energy Regulatory Commission PowerSmith Cogeneration Project, LP; Notice of Request for Waiver Take... Act of 1978 (PURPA), as amended, 18 CFR 292.205(c), PowerSmith Cogeneration Project, LP (PowerSmith... operated by PowerSmith located in Oklahoma. PowerSmith makes such a request because of a delay in...

  12. 76 FR 60733 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY AGENCY... the Smith Point Bridge, 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The.... SUPPLEMENTARY INFORMATION: The Smith Point Bridge, across Narrow Bay, mile 6.1, between Smith Point and...

  13. Chromospheric Variability: Analysis of 36 years of Time Series from the National Solar Observatory/Sacramento Peak Ca II K-line Monitoring Program

    NASA Technical Reports Server (NTRS)

    Scargle, Jeffrey D.; Keil, Stephen L.; Worden, Simon P.

    2014-01-01

    Analysis of more than 36 years of time series of seven parameters measured in the NSO/AFRL/Sac Peak K-line monitoring program elucidates five elucidates five components of the variation: (1) the solar cycle (period approx. 11 years), (2) quasi-periodic variations (periods approx 100 days), (3) a broad band stochastic process (wide range of periods), (4) rotational modulation, and (5) random observational errors. Correlation and power spectrum analyses elucidate periodic and aperiodic variation of the chromospheric parameters. Time-frequency analysis illuminates periodic and quasi periodic signals, details of frequency modulation due to differential rotation, and in particular elucidates the rather complex harmonic structure (1) and (2) at time scales in the range approx 0.1 - 10 years. These results using only full-disk data further suggest that similar analyses will be useful at detecting and characterizing differential rotation in stars from stellar light-curves such as those being produced by NASA's Kepler observatory. Component (3) consists of variations over a range of timescales, in the manner of a 1/f random noise process. A timedependent Wilson-Bappu effect appears to be present in the solar cycle variations (1), but not in the stochastic process (3). Component (4) characterizes differential rotation of the active regions, and (5) is of course not characteristic of solar variability, but the fact that the observational errors are quite small greatly facilitates the analysis of the other components. The recent data suggest that the current cycle is starting late and may be relatively weak. The data analyzed in this paper can be found at the National Solar Observatory web site http://nsosp.nso.edu/cak_mon/, or by file transfer protocol at ftp://ftp.nso.edu/idl/cak.parameters.

  14. Oscar F. Smith Middle School: One Extra Degree

    ERIC Educational Resources Information Center

    Principal Leadership, 2012

    2012-01-01

    This article features Oscar F. Smith Middle School, a challenging school in Chesapeake, Virginia. When Principal Linda Scott exclaims, "Oscar F. Smith Middle School is "hot"!" to visitors, she is not referring to the inside temperature of the bustling school of grades 6-8 located in the historic South Norfolk borough of…

  15. Father Knows Best: Using Adam Smith to Teach Transactions Costs

    ERIC Educational Resources Information Center

    Dupont, Brandon

    2014-01-01

    Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

  16. 1. VIEW OF THE SMITH NO. 3 SITE AREA TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF THE SMITH NO. 3 SITE AREA TO THE NORTHWEST. THE MINE OFFICE BUILDING IS IN THE FOREGROUND AND THE TIPPLE AND PROCESSING PLANT ARE IN THE BACKGROUND. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

  17. Theme: The Smith-Hughes Act at 70.

    ERIC Educational Resources Information Center

    Hillison, John; And Others

    1987-01-01

    Consists of seven articles dealing with the Smith-Hughes Act. Articles discuss (1) accomplishments, (2) the political ratification fight, (3) agricultural education prior to the act, (4) agricultural education a decade later, (5) founding of public vocational education, (6) philosophy of Smith-Hughes, and (7) teacher education. (CH)

  18. Last Interview with W. Eugene Smith on the Photo Essay.

    ERIC Educational Resources Information Center

    Kobre, Ken

    An interview with W. Eugene Smith, well-known photographer and photographic essayist, is presented in this paper. The introductory section of the paper contains a biographical sketch of Smith and a discussion of his photographic essays on a number of topics, including World War II scenes, life in a Spanish village, the work of a black midwife in…

  19. Author! Author! The Gallant Children's Author: Dick King-Smith

    ERIC Educational Resources Information Center

    Brodie, Carolyn S.

    2005-01-01

    This column presents a brief biography of Dick King-Smith. Born on March 27, 1922 and raised in Gloucestershire, England, he grew up with animals of all kinds. King-Smith was a farmer for twenty years and then became a school teacher. He was also a soldier during wartime, a traveling salesman, shoe factory worker, and television presenter. He…

  20. Environmental assessment overview, Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-05-01

    In February 1983, the US Department of Energy (DOE) identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for mined geologic repository for spent nuclear fuel and high-level radioactive waste. To determine their suitability, the Deaf Smith County site and eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories. The Deaf Smith County site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. On the basis of the evaluations reported in this EA, the DOE has found that the Deaf Smith County site is not disqualified under the guidelines. On the basis of these findings, the DOE is nominating the Deaf Smith County site as one of five sites suitable for characterization. 3 figs.

  1. Marshall-Smith syndrome: the expanding phenotype.

    PubMed Central

    Williams, D K; Carlton, D R; Green, S H; Pearman, K; Cole, T R

    1997-01-01

    We report a child of 3 years 9 months with the Marshall-Smith syndrome (MSS), characterised by the typical facial features, developmental delay, and advanced bone age. After the diagnosis was made at 5 months of age, careful observation for respiratory complications and failure to thrive was initiated. By 3 1/2 years of age, although our patient had no life threatening respiratory complications, investigation showed significant upper airway obstruction, which has been successfully treated. Aggressive treatment for failure to thrive has also allowed her to maintain a weight on the 50th centile. The purpose of this report is to suggest that early diagnosis and aggressive management may improve the ultimate prognosis with respect to the respiratory and feeding difficulties seen in this rare syndrome. Images PMID:9350818

  2. Trinucleotide repeat expansion and DRPLA (Smith`s disease): Molecular characterization of atrophin-1

    SciTech Connect

    Margolis, R.L.; Li, S.H.; Li, X.J.; Ross, C.A.

    1994-09-01

    Smith`s disease (also known as dentatorubral pallidoluysian atrophy or DRPLA) is a rare, progressive, fatal neuropsychiatric disorder similar to Huntington`s disease (HD). Smith`s disease is characterized by ataxia, choreoathetosis, myoclonic epilepsy, dementia, and genetic anticipation. Neuropathological findings include prominent cell loss in the dentate nucleus of the cerebellum, the globus pallidus, the red nucleus, and the subthalamic nucleus. An expansion of a CAG trinucleotide repeat encoding polyglutamine in a gene originally identified in our laboratory as part of a program to clone candidate genes for disorders with anticipation has recently been found to cause this disorder. We have identified two families that demonstrate the pathological and genetic features (expanded CAG repeat and anticipation) of this disease. Northern analysis indicates that the gene, which we have termed atrophin-1, is widely expressed as a 5 kb mRNA in normal human brain and peripheral tissues. Brain expression is highest in the cerebellum. The developmental expression of the rat homologues of IT-15 (the gene in which a CAG expansion causes HD) and atrophin-1 were compared. Atrophin-1 was most highly expressed in early rat embryo brain (E16), whereas the greatest expression of IT-15 was in the adult rat brain. Cloning and sequencing of the open reading frame from inserts contained in brain cDNA libraries is in progress. In addition to the CAG repeat, the ORF contains an unusual region of alternating acidic and basic amino acids. Further characterization of atrophin-1, and comparison of it to other genes in which trinucleotide repeat expansion leads to neuropsychiatric disorders, should lead to a better understanding of the pathophysiology by which CAG repeat expansion causes human disease.

  3. Psychosocial aspects of epilepsy: a wider approach

    PubMed Central

    Mula, Marco

    2016-01-01

    Summary Epilepsy is one of the most serious neurological conditions and has an impact not only on the affected individual but also on the family and, indirectly, on the community. A global approach to the individual must take into account cognitive problems, psychiatric comorbidities and all psychosocial complications that often accompany epilepsy. We discuss psychosocial issues in epilepsy with special focus on the relationship between stigma and psychiatric comorbidities. Social barriers to optimal care and health outcomes for people with epilepsy result in huge disparities, and the public health system needs to invest in awareness programmes to increase public knowledge and reduce stigma in order to minimise such disparities. Declarations of interest J.W.S. receives research support from the Dr Marvin Weil Epilepsy Research Fund, Eisai, GlaxoSmithKline, the World Health Organization and the EU’s FP7 programme, and has been consulted by, and has received fees for lectures from, GlaxoSmithKline, Eisai, Lundbeck, Teva and UCB. Copyright and usage © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license. PMID:27703786

  4. Mechanistic insights into influenza vaccine-associated narcolepsy

    PubMed Central

    Ahmed, S. Sohail; Steinman, Lawrence

    2016-01-01

    ABSTRACT We previously reported an increased frequency of antibodies to hypocretin (HCRT) receptor 2 in sera obtained from narcoleptic patients who received the European AS03-adjuvanted vaccine Pandemrix (GlaxoSmithKline Biologicals, s.a.) for the global influenza A H1N1 pandemic in 2009 [A(H1N1)pdm09]. These antibodies cross-reacted with a particular fragment of influenza nucleoprotein (NP) – one of the proteins naturally contained in the virus used to make seasonal influenza vaccine and pandemic influenza vaccines. The purpose of this commentary is to provide additional insights and interpretations of the findings and share additional data not presented in the original paper to help the reader appreciate the key messages of that publication. First, a brief background to narcolepsy and vaccine-induced narcolepsy will be provided. Then, additional insights and clarification will be provided on the following topics: 1) the critical difference identified in the adjuvanted A(H1N1)pdm09 vaccines, 2) the contributing factor likely for the discordant association of narcolepsy between the AS03-adjuvanted pandemic vaccines Pandemrix and Arepanrix (GlaxoSmithKline Biologicals, s.a.), 3) the significance of detecting HCRT receptor 2 (HCRTr2) antibodies in some Finnish control subjects, 4) the approach used for the detection of HCRTr2 antibodies in vaccine-associated narcolepsy, and 5) the plausibility of the proposed mechanism involving HCRTr2 modulation in vaccine-associated narcolepsy. PMID:27031682

  5. Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

    PubMed

    Aigbirhio, F I; Allwein, S; Anwar, A; Atzrodt, J; Audisio, D; Badman, G; Bakale, R; Berthon, F; Bragg, R; Brindle, K M; Bushby, N; Campos, S; Cant, A A; Chan, M Y T; Colbon, P; Cornelissen, B; Czarny, B; Derdau, V; Dive, V; Dunscombe, M; Eggleston, I; Ellis-Sawyer, K; Elmore, C S; Engstrom, P; Ericsson, C; Fairlamb, I J S; Georgin, D; Godfrey, S P; He, L; Hickey, M J; Huscroft, I T; Kerr, W J; Lashford, A; Lenz, E; Lewinton, S; L'Hermite, M M; Lindelöf, Å; Little, G; Lockley, W J S; Loreau, O; Maddocks, S; Marguerit, M; Mirabello, V; Mudd, R J; Nilsson, G N; Owens, P K; Pascu, S I; Patriarche, G; Pimlott, S L; Pinault, M; Plastow, G; Racys, D T; Reif, J; Rossi, J; Ruan, J; Sarpaki, S; Sephton, S M; Simonsson, R; Speed, D J; Sumal, K; Sutherland, A; Taran, F; Thuleau, A; Wang, Y; Waring, M; Watters, W H; Wu, J; Xiao, J

    2016-04-01

    The 24th annual symposium of the International Isotope Society's United Kingdom Group took place at the Møller Centre, Churchill College, Cambridge, UK on Friday 6th November 2015. The meeting was attended by 77 delegates from academia and industry, the life sciences, chemical, radiochemical and scientific instrument suppliers. Delegates were welcomed by Dr Ken Lawrie (GlaxoSmithKline, UK, chair of the IIS UK group). The subsequent scientific programme consisted of oral presentations, short 'flash' presentations in association with particular posters and poster presentations. The scientific areas covered included isotopic synthesis, regulatory issues, applications of labelled compounds in imaging, isotopic separation and novel chemistry with potential implications for isotopic synthesis. Both short-lived and long-lived isotopes were represented, as were stable isotopes. The symposium was divided into a morning session chaired by Dr Rebekka Hueting (University of Oxford, UK) and afternoon sessions chaired by Dr Sofia Pascu (University of Bath, UK) and by Dr Alan Dowling (Syngenta, UK). The UK meeting concluded with remarks from Dr Ken Lawrie (GlaxoSmithKline, UK).

  6. STS-82 Mission Specialist Steven L. Smith Suit Up

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-82 Mission Specialist Steven L. Smith gives a ''';thumbs up'''; while donning his launch and entry suit in the Operations and Checkout Building. A suit technician stands ready to assist with final adjustments. This is Smith''';s second space flight. He and the six other crew members will depart shortly for Launch Pad 39A, where the Space Shuttle Discovery awaits liftoff on a 10-day mission to service the orbiting Hubble Space Telescope (HST). This will be the second HST servicing mission. Four back-to-back spacewalks are planned.

  7. Dermatologic features of Smith-Magenis syndrome.

    PubMed

    Guérin-Moreau, Morgane; Colin, Estelle; Nguyen, Sylvie; Andrieux, Joris; de Leersnyder, Hélène; Bonneau, Dominique; Martin, Ludovic

    2015-01-01

    Smith-Magenis syndrome (SMS) is characterized by distinctive facial and skeletal features, developmental delay, cognitive impairment, and behavioral abnormalities, including self-injurious behaviors. We aimed to investigate whether cutaneous features are common in SMS. We performed a complete skin examination in 20 young SMS patients. Skin features secondary to self-injurious behavior, such as bites, abrasions, dystrophic scars, limited spots of hyperkeratosis, anomalies of the nails, and whitlows, were found in the majority of patients. Acral pachydermia and fissured plantar keratoderma were common. Xerosis was constant and associated with extensive keratosis pilaris in the majority of patients. Dermatofibromas were frequent in older patients. The hair was dense and shiny, with an unusual hairline. Eyelash trichomegaly and heavy brows were common, as well as folliculitis on the back. The skin features of SMS have rarely been reported in the literature. Some of these are the consequence of neurobehavioral features, but some cutaneous features and abnormalities of appendages have not been reported in other related syndromes. Skin manifestations of SMS are varied, sometimes induced by self-injurious behavior and sometimes more specific. It remains to be determined whether the combination of the two kinds of signs could contribute to early diagnosis of the syndrome.

  8. Fred Spilhaus Receives 2010 Waldo E. Smith Medal

    NASA Astrophysics Data System (ADS)

    Harrison, Christopher; Burch, James; Spilhaus, Fred

    2011-02-01

    Fred Spilhaus was awarded the 2010 Waldo E. Smith Medal at the AGU Fall Meeting Honors Ceremony, held on 15 December 2010 in San Francisco, Calif. The medal is for “extraordinary service to geophysics.”

  9. RadNet Air Data From Fort Smith, AR

    EPA Pesticide Factsheets

    This page presents radiation air monitoring and air filter analysis data for Fort Smith, AR from EPA's RadNet system. RadNet is a nationwide network of monitoring stations that measure radiation in air, drinking water and precipitation.

  10. Meet EPA Scientist Betsy Smith, Ph.D.

    EPA Pesticide Factsheets

    Dr. Betsy Smith is Associate National Program Director for Systems Analysis within the Sustainable and Healthy Communities Research Program. Her work has focused on new methods to analyze spatial data on multiple problems.

  11. Conversations with Patricia Grace Smith. Interview by Frank Sietzen Jr.

    PubMed

    Smith, Patricia Grace

    2004-02-01

    Ms. Smith, associate administrator for commercial space transportation within the Federal Aviation Administration, answers questions about regulations and licensing related to reusable launch vehicles, space passenger vehicles, and commercial space ventures.

  12. 19. Photocopy of photograph (from Frances Rand Smith Collection, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Photocopy of photograph (from Frances Rand Smith Collection, California Historical Society, 1880) Photographer unknown, April 1940 EXTERIOR VIEW OF REAR OF CHURCH - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

  13. 20. Photocopy of photograph (From Frances Rand Smith Collection, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Photocopy of photograph (From Frances Rand Smith Collection, California Historical Society) Photographer unknown, Date unknown VIEW OF CHURCH FROM REAR - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

  14. 16. Photocopy of photograph (from Frances Rand Smith Collection, California ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Photocopy of photograph (from Frances Rand Smith Collection, California Historical Society, 1900) Photographer unknown, Date unknown FRONT VIEW OF MISSION, c. 1900 - Mission San Miguel Arcangel, Highway 101, San Miguel, San Luis Obispo County, CA

  15. David Simpson Receives 2012 Waldo E. Smith Medal: Citation

    NASA Astrophysics Data System (ADS)

    Lerner-Lam, Arthur

    2013-01-01

    David Simpson was awarded the 2012 Waldo E. Smith Medal at the AGU Fall Meeting Honors Ceremony, held on 5 December 2012 in San Francisco, Calif. The medal is for "extraordinary service to geophysics".

  16. STS-82 M.S. Steven Smith in White Room

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-82 Mission Specialist Steven L. Smith prepares to enter the Space Shuttle Discovery at Launch Pad 39A, with the assistance of white room closeout crew members Dave Law, in front; Carlous Gillis, at left; and James Davis.

  17. 8. Historic American Buildings Survey Delos H. Smith, Photographer 1936 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Historic American Buildings Survey Delos H. Smith, Photographer 1936 - Dr. David Ross House, Annapolis Road (moved to Preservation Hill, Western Run Road, Cockeysville), Bladensburg, Prince George's County, MD

  18. DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL OF WESTINGHOUSE AND B. MORGAN SMITH NAMEPLATES ON ELECTRIC GENERATOR IN UPPER LEVEL OF HYDROELECTRIC POWER HOUSE - St. Lucie Canal, Lock No. 1, Hydroelectric Power House, St. Lucie, Cross State Canal, Okeechobee Intracoastal Waterway, Stuart, Martin County, FL

  19. On some problems related to the Hilbert-Smith conjecture

    NASA Astrophysics Data System (ADS)

    Dranishnikov, A. N.

    2016-11-01

    The Hilbert-Smith conjecture claims that if a compact group G acts freely on a manifold, then it is a Lie group. For a finite-dimensional orbit space a reduction of the Hilbert-Smith conjecture to certain other problems in geometric topology is presented; in these the key problem is the existence of an essential sequence of lens spaces of increasing dimension. Bibliography: 52 titles.

  20. STS-82 Mission Specialist Steven L. Smith during TCDT

    NASA Technical Reports Server (NTRS)

    1997-01-01

    STS-82 Mission Specialist Steven L. Smith adjusts the glove of his launch and entry space suit during a practice countdown at KSC. Smith and the other six STS-82 crew members are at KSC to participate in the Terminal Countdown Demonstration Test (TCDT), a dress rehearsal for launch. STS-82 will be the second Hubble Space Telescope servicing mission. Liftoff is targeted for February 11.

  1. Polydactyly in a boy with Smith-Magenis syndrome.

    PubMed

    Mariannejensen, Lisbeth; Kirchhoff, Maria

    2005-10-01

    Smith-Magenis syndrome is a microdeletion syndrome involving chromosome 17p11.2. The characteristic features include mental retardation, dysmorphic facial features, minor skeletal anomalies including brachydactyly and behavioural abnormalities, such as disturbed sleep pattern, restlessness and self-destructive behaviour. We present a patient with this syndrome and with six digits on each hand. Polydactyly has not yet been described in Smith-Magenis syndrome as far as we know.

  2. 78 FR 23845 - Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ... SECURITY Coast Guard 33 CFR Part 117 Drawbridge Operation Regulations; Narrow Bay, Smith Point, NY AGENCY... the Smith Point Bridge, mile 6.1, across Narrow Bay, between Smith Point and Fire Island, New York. The deviation is necessary to facilitate the Smith Point Triathlon. This deviation allows the...

  3. 76 FR 4648 - PowerSmith Cogeneration Project, LP; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... Energy Regulatory Commission PowerSmith Cogeneration Project, LP; Notice of Filing January 19, 2011. Take notice that on January 13, 2011, PowerSmith Cogeneration Project, LP (PowerSmith), pursuant to section... Regulations for the topping-cycle cogeneration facility owned and operated by PowerSmith located in...

  4. Correction to Smith et al. (2013).

    PubMed

    Smith, Carl D; Piasecki, Christopher C; Weera, Marcus; Olszewicz, Joshua; Lonstein, Joseph S

    2015-08-01

    Reports an error in "Noradrenergic alpha-2 receptor modulators in the ventral bed nucleus of the stria terminalis: Effects on anxiety behavior in postpartum and virgin female rats" by Carl D. Smith, Christopher C. Piasecki, Marcus Weera, Joshua Olszewicz and Joseph S. Lonstein (Behavioral Neuroscience, 2013[Aug], Vol 127[4], 582-597). Table 2 should have used the ratio of 5HIAA/serotonin - rather than the inverse - as the indicator of serotonin turnover. Using the correct ratio, differences in serotonin turnover between the postpartum and virgin females are: BSTv - 1.11 0.06 vs 0.79 0.11 (t 2.57, p 0.05); BSTd - 1.01 0.07 vs 0.68 0.11 (t 2.58, p 0.05). That is, contrary to what was originally reported, postpartum females had higher serotonin turnover in both subregions of the BST compared to virgins. The penultimate sentence in the abstract noting serotonin turnover in mothers has been corrected in the online version of this article. (The following abstract of the original article appeared in record 2013-22430-001.) Emotional hyperreactivity can inhibit maternal responsiveness in female rats and other animals. Maternal behavior in postpartum rats is disrupted by increasing norepinephrine release in the ventral bed nucleus of the stria terminalis (BSTv) with the α2-autoreceptor antagonist, yohimbine, or the more selective α2-autoreceptor antagonist, idazoxan (Smith et al., 2012). Because high noradrenergic activity in the BSTv can also increase anxiety-related behaviors, increased anxiety may underlie the disrupted mothering of dams given yohimbine or idazoxan. To assess this possibility, anxiety-related behaviors in an elevated plus maze were assessed in postpartum rats after administration of yohimbine or idazoxan. It was further assessed if the α2-autoreceptor agonist clonidine (which decreases norepinephrine release) would, conversely, reduce dams' anxiety. Groups of diestrous virgins were also examined. It was found that peripheral or intra-BSTv yohimbine

  5. SR-71 Pilot Rogers E. Smith

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Research pilot Rogers E. Smith is shown here in front of the SR-71 Blackbird he flew for NASA. Rogers was one of the two original NASA research pilots assigned to the SR-71 high speed research program at NASA's Ames-Dryden Flight Research Facility (later, Dryden Flight Research Center, Edwards, California. Smith has been a NASA research pilot at Dryden since 1982. Data from the SR-71 program will be used to aid designers of future supersonic aircraft and propulsion systems. The SR-71 is capable of flying more than 2200 mph (Mach 3+) and at altitudes of over 80,000 feet. Two SR-71 aircraft have been used by NASA as testbeds for high-speed and high-altitude aeronautical research. The aircraft, an SR-71A and an SR-71B pilot trainer aircraft, have been based here at NASA's Dryden Flight Research Center, Edwards, California. They were transferred to NASA after the U.S. Air Force program was cancelled. As research platforms, the aircraft can cruise at Mach 3 for more than one hour. For thermal experiments, this can produce heat soak temperatures of over 600 degrees Fahrenheit (F). This operating environment makes these aircraft excellent platforms to carry out research and experiments in a variety of areas -- aerodynamics, propulsion, structures, thermal protection materials, high-speed and high-temperature instrumentation, atmospheric studies, and sonic boom characterization. The SR-71 was used in a program to study ways of reducing sonic booms or over pressures that are heard on the ground, much like sharp thunderclaps, when an aircraft exceeds the speed of sound. Data from this Sonic Boom Mitigation Study could eventually lead to aircraft designs that would reduce the 'peak' overpressures of sonic booms and minimize the startling affect they produce on the ground. One of the first major experiments to be flown in the NASA SR-71 program was a laser air data collection system. It used laser light instead of air pressure to produce airspeed and attitude reference data

  6. Description of floodplains and wetlands, Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1986-11-01

    Floodplains and wetlands are important features of the Texas Panhandle landscape, and are found on the Deaf Smith County site and in its vicinity. Use or disturbance of floodplains and wetlands in relation to the Civilian Radioactive Waste Management Program is subject to environmental review requirements implementing two Executive Orders. This report provides general information on playa wetlands in the Texas Panhandle, and describes and maps floodplains and wetlands on the Deaf Smith site and in its vicinity. The report is based on the published literature, with information from limited field reconnaissance included.

  7. Robert William Smith: his life and his contributions to medicine.

    PubMed

    Shah, Hriday M; Chung, Kevin C

    2008-01-01

    Robert William Smith is best known for the eponymous Smith's fracture. He also made other important contributions to medicine and medical education, publishing on topics ranging from arthritis to neuroma. He had a great interest in pathology and helped found the Pathological Society of Dublin. At the time of his death, he was the vice president of the Royal College of Surgeons in Ireland. His contributions to the understanding of various pathologic conditions make him an important figure in medicine and in hand surgery.

  8. X-29 Research Pilot Rogers Smith

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Rogers Smith, a NASA research pilot, is seen here at the cockpit of the X-29 forward-swept-wing technology demonstrator at NASA's Ames-Dryden Flight Research Facility (later the Dryden Flight Research Center), Edwards, California, in 1988. The X-29 explored the use of advanced composites in aircraft construction; variable camber wing surfaces; the unique forward-swept-wing and its thin supercritical airfoil; strake flaps; and a computerized fly-by-wire flight control system that overcame the aircraft's instability. Grumman Aircraft Corporation built two X-29s. They were flight tested at Dryden from 1984 to 1992 in a joint NASA, DARPA (Defense Advanced Research Projects Agency) and U.S. Air Force program. Two X-29 aircraft, featuring one of the most unusual designs in aviation history, flew at the Ames-Dryden Flight Research Facility (now the Dryden Flight Research Center, Edwards, California) from 1984 to 1992. The fighter-sized X-29 technology demonstrators explored several concepts and technologies including: the use of advanced composites in aircraft construction; variable-camber wing surfaces; a unique forward- swept wing and its thin supercritical airfoil; strakes; close-coupled canards; and a computerized fly-by-wire flight control system used to maintain control of the otherwise unstable aircraft. Research results showed that the configuration of forward-swept wings, coupled with movable canards, gave pilots excellent control response at angles of attack of up to 45 degrees. During its flight history, the X-29 aircraft flew 422 research missions and a total of 436 missions. Sixty of the research flights were part of the X-29 follow-on 'vortex control' phase. The forward-swept wing of the X-29 resulted in reverse airflow, toward the fuselage rather than away from it, as occurs on the usual aft-swept wing. Consequently, on the forward-swept wing, the ailerons remained unstalled at high angles of attack. This provided better airflow over the ailerons and

  9. Class Size Revisited: Glass and Smith in Perspective.

    ERIC Educational Resources Information Center

    Hess, Fritz

    Gene V. Glass and Mary Lee Smith claim in their report, "Meta-Analysis of Research on the Relationship of Class-Size and Achievement" (ED 168 129), that their integration of data from 80 previous studies through complex regression analysis techniques revealed a "clear and strong relationship" between decreases in class size and increases in…

  10. Smith Assists in Superstorm Sandy Relief Efforts | Poster

    Cancer.gov

    By Cathy McClintock, Guest Writer It should have been routine by now for a 30-year volunteer firefighter/ emergency medical technician from Thurmont, Md., but it wasn’t. That first night, as Ross Smith, IT security, looked across the Hudson River from Jersey City, N.J., he saw an unusually dark New York skyline.

  11. The Garrett Lee Smith Memorial Suicide Prevention Program

    ERIC Educational Resources Information Center

    Goldston, David B.; Walrath, Christine M.; McKeon, Richard; Puddy, Richard W.; Lubell, Keri M.; Potter, Lloyd B.; Rodi, Michael S.

    2010-01-01

    In response to calls for greater efforts to reduce youth suicide, the Garrett Lee Smith (GLS) Memorial Act has provided funding for 68 state, territory, and tribal community grants, and 74 college campus grants for suicide prevention efforts. Suicide prevention activities supported by GLS grantees have included education, training programs…

  12. Karen Smith: Language Arts Educator of the Year

    ERIC Educational Resources Information Center

    Hudelson, Sarah

    2009-01-01

    This article honors Karen Smith, who has been given NCTE's Outstanding Educator in the English Language Arts award for 2009. Through the voices of many colleagues and former students, the article celebrates Karen as a teacher, learner, mentor, collaborator, scholar, storyteller, and visionary thinker and doer.

  13. 20. Historic American Buildings Survey Mr. Smith, Draftsman June 1908 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Historic American Buildings Survey Mr. Smith, Draftsman June 1908 BROWN LINE OF ORIGINAL DRAWING OF MAILING PLATFORM From the Collection of Dan Peterson, A.I.A. Architect - Santa Rosa Post Office & Federal Building, 401 Fifth Street (moved to Seventh Street), Santa Rosa, Sonoma County, CA

  14. Gas Currently Accreting Onto the Milky Way: The Smith Cloud

    NASA Astrophysics Data System (ADS)

    Lockman, Felix James

    2015-08-01

    Active gas accretion onto the Milky Way is observed in an object called the Smith Cloud, which contains several million solar masses of neutral and warm ionized gas. It is several kpc in size and is located two kpc below the Galactic plane, on a trajectory that will intersect the Galactic plane in a few tens of million years, fueling future generations of star formation in the inner half of the Milky Way.The Smith Cloud appears to be purely gaseous with no stellar counterpart, but there are suggestions that its existence and survival require that it be embedded in a dark matter halo of a few 10^8 solar masses.The Smith Cloud is interacting with the Milky Way's gaseous halo and losing mass to it; the interaction shows indications of Raleigh-Taylor and Kelvin-Helmholtz instabilities. Portions of the cloud have already been decellerated to near local rest velocity in the halo. It may have a magnetic field.I will present new 21cm HI observations of the Smith Cloud made with the Green Bank Telescope that bear on its origin and fate. New UV spectra from COS/HST will also be presented that give estimates of its abundances and ionization stage.

  15. Smith-Magenis Syndrome: Genetic Basis and Clinical Implications

    ERIC Educational Resources Information Center

    Finucane, Brenda; Haas-Givler, Barbara

    2009-01-01

    Smith-Magenis syndrome (SMS) is a neurobehavioral disorder associated with deletions and mutations of the "RAI1" gene on chromosome 17p11.2. Clinical features of the syndrome include intellectual disability, sleep disturbance, craniofacial differences, and a distinctive profile of stereotypic and self-injurious behaviors. Although the functional…

  16. David E. Smith Receives 2012 Charles A. Whitten Medal: Citation

    NASA Astrophysics Data System (ADS)

    Phillips, Roger J.

    2013-01-01

    David E. Smith was awarded the 2012 Charles A. Whitten Medal at the AGU Fall Meeting Honors Ceremony, held on 5 December 2012 in San Francisco, Calif. The medal is for "outstanding achievement in research on the form and dynamics of the Earth and planets."

  17. Adam Smith and the Moral Economy of the Classroom System.

    ERIC Educational Resources Information Center

    Hamilton, D.

    1980-01-01

    Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

  18. Adam Smith and the Teaching of English Literature.

    ERIC Educational Resources Information Center

    Court, Franklin E.

    1985-01-01

    Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

  19. Captain John Smith and the Enterprise of Virginia: Update.

    ERIC Educational Resources Information Center

    Schick, James B. M.

    1986-01-01

    This article describes the modern-day equivalent prices of items Captain John Smith required for colonists traveling from England to Virginia in 1624. Includes information on wages and cost of living in 1624 and today in the United States. Concludes that the colonists paid a high price for traveling to the New World. (JDH)

  20. New Maps for Old? A Reply to Smith.

    ERIC Educational Resources Information Center

    Pickles, John

    1986-01-01

    Pickles replies that Smith's critique masks the concrete experience of everyday understanding. The issue of education is not about the transmission of information, but one about how we produce and reproduce our social world. Education must permit rational discourse and decision making within the context of a moral community. (CJH)

  1. Examining Foundational Understandings: Ralph Smith's Contributions to the DBAE Challenge

    ERIC Educational Resources Information Center

    DiBlasio, Margaret Klempay

    2002-01-01

    This essay is based on work the author began several years ago when she undertook to analyze and compare the diverse descriptions of discipline-based art education that had appeared in the professional art education literature. It compared concepts of Discipline-Based Art Education (DBAE) presented in writings by Ralph Smith; Gilbert Clark,…

  2. Pharmacological Cognitive Enhancers: Comment on Smith and Farah (2011)

    ERIC Educational Resources Information Center

    Elliott, Glen R.; Elliott, Mark D.

    2011-01-01

    Smith and Farah (2011) provided a thought-provoking and perhaps deliberately provocative literature review of the use of stimulants to improve cognitive functioning in humans. They addressed the apparently increasing willingness of individuals mostly in the United States to use stimulants for this purpose and then summarized published literature…

  3. [Speech impairment and the Smith-Magenis syndrome].

    PubMed

    Bergmann, C; Morlot, S; Ptok, M

    2007-08-01

    The Smith-Magenis syndrome (SMS) is a distinct multiple congenital anomaly caused by an interstitial deletion of the chromosome 17 p11.2. The phenotype includes dysmorphic features, mental retardation, speech delay, signs of peripheral neuropathy, and neurobehavioral problems. Also sensorineural and conduction hearing loss are described. In children with speech delay the physician should consider a genetic or syndromal disease.

  4. Return to Baseline: Some Comments on Smith's Reinterpretation of Seclusionary Timeout.

    ERIC Educational Resources Information Center

    Polsgrove, Lewis

    1982-01-01

    The author replies to an earlier contention of D. Smith (EC 133 830) that seclusionary timeout for behavior disordered children actually constitutes extinction rather than aversive control. The author cites methodological flaws in Smith's studies. (CL)

  5. Modeling Ocean-Forced Changes in Smith Glacier

    NASA Astrophysics Data System (ADS)

    Lilien, D.; Joughin, I. R.; Smith, B. E.

    2014-12-01

    Glaciers along the Amundsen Coast are changing rapidly, which has drawn substantial scientific and public attention. Modeling and observation suggest warm-water intrusion and consequent melting as the cause of observed changes, and that unstoppable retreat may have already been triggered in some drainages. While Pine Island and Thwaites Glaciers are losing the most mass and have been the predominant objects study, other systems, particularly Smith, Pope and Kohler Glaciers and the corresponding Dotson and Crosson Shelves, are changing more rapidly relative to their size. Though smaller, these glaciers still have potentially large implications for overall regional dynamics as their beds connect below sea level to surrounding basins. In particular, the long, deep trough of Smith Glacier nearly links to the large eastern tributary of Thwaites, potentially causing rapid changes of Smith to have significant impact on the continuing retreat of Thwaites.We implemented a numerical model in Elmer/Ice, an open-source, full-Stokes, finite-element software package, to investigate the response of the Smith/Pope/Kohler system to different initial conditions. We use various parameterizations of sub-shelf melting with constant magnitude to examine the sensitivity of overall dynamics to melt distribution. Because melt distribution affects lateral buttressing and upstream grounded areas, it is potentially an important control on ice shelf and outlet glacier dynamics. Through comparison to the most recent velocity data, we evaluate the ability of differing melt parameterizations to reproduce the behavior currently seen in Smith/Pope/Kohler glaciers. In addition, we investigate the effect of using different years of velocity data with constant elevation input when initiating model runs. By comparing results over the satellite record to initiation with synchronous observations, we assess the accuracy of the often necessary practice of using differently timestamped datasets.

  6. A Cabinet of Mathematical Curiosities at Teachers College: David Eugene Smith's Collection

    ERIC Educational Resources Information Center

    Murray, Diane R.

    2012-01-01

    This dissertation is a history of David Eugene Smith's collection of historical books, manuscripts, portraits, and instruments related to mathematics. The study analyzes surviving documents, images, objects, college announcements and catalogs, and secondary sources related to Smith's collection. David Eugene Smith (1860-1944) travelled…

  7. 75 FR 37462 - Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... National Park Service Official Trail Marker for the Captain John Smith Chesapeake National Historic Trail....S.C. 701. SUMMARY: This notice issues the official trail marker insignias of the Captain John Smith... John Maounis, Superintendent, Captain John Smith Chesapeake National Historic Trail. The...

  8. 77 FR 2317 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... National Park Service Captain John Smith Chesapeake National Historic Trail Advisory Council AGENCY... Captain John Smith Chesapeake National Historic Trail will hold a meeting via conference call. Designated... voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This meeting...

  9. 77 FR 64352 - Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... National Park Service Notice of Meeting for Captain John Smith Chesapeake National Historic Trail Advisory... Advisory Committee on the Captain John Smith Chesapeake National Historic Trail will hold a meeting...-1609 voyages of Captain John Smith to chart the land and waterways of the Chesapeake Bay. This...

  10. 40 CFR 81.63 - Metropolitan Fort Smith Interstate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Metropolitan Fort Smith Interstate Air... Air Quality Control Regions § 81.63 Metropolitan Fort Smith Interstate Air Quality Control Region. The Metropolitan Fort Smith Interstate Air Quality Control Region (Arkansas-Oklahoma) has been revised to...

  11. 78 FR 32250 - CDM Smith and Dynamac Corp; Transfer of Data

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... AGENCY CDM Smith and Dynamac Corp; Transfer of Data AGENCY: Environmental Protection Agency (EPA). ACTION... Confidential Business Information (CBI) by the submitter, will be transferred to CDM Smith and its subcontractor, Dynamac Corp, in accordance with 40 CFR 2.307(h)(3) and 2.308(i)(2). CDM Smith and...

  12. Green Bank Telescope OH Observations of Smith's Cloud: Evidence Of A Lack Of Chemistry

    NASA Astrophysics Data System (ADS)

    Minter, Anthony

    2017-03-01

    Smith's Cloud is a large few × 106 Solar Mass cloud which will impact the Milk Way disk in about 35 Million Years (Lockman et al., 2008). Green Bank Telescope OH observations indicate that there are no molecules present in Smith's Cloud, and thus there is no active ongoing chemistry in Smith's Cloud.

  13. 77 FR 64411 - Safety Zone; Cooper T. Smith Fireworks Event; Mobile River; Mobile, AL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Cooper T. Smith Fireworks Event; Mobile... during the Cooper T. Smith Fireworks Event. Entry into, transiting or anchoring in this zone is... Cooper T. Smith Corp. has hired Pyro Tecnico to conduct a fireworks display on the Mobile River,...

  14. SMITH: a LIMS for handling next-generation sequencing workflows

    PubMed Central

    2014-01-01

    Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to troubleshoot problems, to maintain a high quality standard, to reduce time and costs. Commercial and non-commercial tools called LIMS (Laboratory Information Management Systems) are available for this purpose. However, they often come at prohibitive cost and/or lack the flexibility and scalability needed to adjust seamlessly to the frequently changing protocols employed. In order to manage the flow of sequencing data produced at the Genomic Unit of the Italian Institute of Technology (IIT), we developed SMITH (Sequencing Machine Information Tracking and Handling). Methods SMITH is a web application with a MySQL server at the backend. Wet-lab scientists of the Centre for Genomic Science and database experts from the Politecnico of Milan in the context of a Genomic Data Model Project developed SMITH. The data base schema stores all the information of an NGS experiment, including the descriptions of all protocols and algorithms used in the process. Notably, an attribute-value table allows associating an unconstrained textual description to each sample and all the data produced afterwards. This method permits the creation of metadata that can be used to search the database for specific files as well as for statistical analyses. Results SMITH runs automatically and limits direct human interaction mainly to administrative tasks. SMITH data-delivery procedures were standardized making it easier for biologists and analysts to navigate the data. Automation also helps saving time. The

  15. Improving performance using cascade control and a Smith predictor.

    PubMed

    Kaya, I

    2001-01-01

    Many investigations have been done on tuning proportional-integral-derivative (PID) controllers in single-input single-output (SISO) systems. However, only a few investigations have been carried out on tuning PID controllers in cascade control systems. In this paper, a new approach, namely the use of a Smith predictor in the outer loop of a cascade control system, is investigated. The method can be used in temperature control problems where the secondary part of the process (the inner loop) may have a negligible delay while the primary loop (the outer loop) has a time-delay. Two different approaches, including an autotuning method, to find the controller parameters are proposed. It is shown by some examples that the proposed structure as expected can provide better performance than conventional cascade control, a Smith predictor scheme or single feedback control system.

  16. Empathy's purity, sympathy's complexities; De Waal, Darwin and Adam Smith.

    PubMed

    van der Weele, Cor

    2011-07-01

    Frans de Waal's view that empathy is at the basis of morality directly seems to build on Darwin, who considered sympathy as the crucial instinct. Yet when we look closer, their understanding of the central social instinct differs considerably. De Waal sees our deeply ingrained tendency to sympathize (or rather: empathize) with others as the good side of our morally dualistic nature. For Darwin, sympathizing was not the whole story of the "workings of sympathy"; the (selfish) need to receive sympathy played just as central a role in the complex roads from sympathy to morality. Darwin's understanding of sympathy stems from Adam Smith, who argued that the presence of morally impure motives should not be a reason for cynicism about morality. I suggest that De Waal's approach could benefit from a more thorough alignment with the analysis of the workings of sympathy in the work of Darwin and Adam Smith.

  17. Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.

    PubMed

    Gabrinetti, Paul A; Özler, Sule

    2014-10-01

    In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system.

  18. Smith Newton Vehicle Performance Evaluation - 3rd Quarter 2012 (Brochure)

    SciTech Connect

    Not Available

    2013-03-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. Through this project, Smith Electric Vehicles will build and deploy 500 all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

  19. Memorial to Robert Leland Smith 1920-2016

    USGS Publications Warehouse

    Bacon, Charles R.

    2016-01-01

    Robert L. Smith, renowned volcanologist and distinguished scientist with the U.S. Geological Survey (USGS), was a world authority on ash-flow tuffs, silicic volcanism, and caldera structures. Bob died peacefully in Sacramento, California, June 17, 2016, a few days short of his ninety-sixth birthday. His publications on ash flows and their deposits brought about an international revolution in understanding of explosive silicic volcanism and, in his fifty-year career, he profoundly influenced USGS programs and countless scientists.

  20. Building Energy Audit Report for Camp Smith, HI

    SciTech Connect

    Chvala, William D.; De La Rosa, Marcus I.; Brown, Daryl R.; Dixon, Douglas R.

    2010-09-30

    A detailed energy assessment was performed by a team of engineers from Pacific Northwest National Laboratory (PNNL) under contract to the Department of Energy/Federal Energy Management program (FEMP). The effort used the Facility Energy Decision System (FEDS) model to determine how energy is consumed at Camp Smith, identify the most cost-effective energy retrofit measures, and calculate the potential energy and cost savings. This report documents the results of that assessment.

  1. Starry Campus: Reducing Light Pollution at Smith College

    NASA Astrophysics Data System (ADS)

    Brenon, Alexandria

    2017-01-01

    This is the start of a program to teach Smith College students about the dangers posed by light pollution and inspire them to help make Smith a better dark sky area. This will focus both on general astronomy education to catch their interest and speciic light pollution information as well. My advisor is creating an initiative for dark skies education and preservation on college campuses, with this as the pilot program. College students can help both on campus and off when they will be able to take what they learn to inform their decisions about lighting when they move out on their own. The ultimate goal is to convince Smith College to make the changes it needs to reduce its light pollution as well as to motivate its students to learn more about astronomy and light pollution. I am developing an education and outreach program using venues such as house teas, lectures, and meetings to teach other students, the staff, and faculty about the issue. I am also working with existing clubs and organizations on campus such as the Green Team, the landscape studies department, and the Center for the Environment, Ecological Design, and Sustainability. This will help to develop campus lighting standards. These lighting standards will be proposed to the college, as there are no current standards in place for lighting around campus.

  2. Manipulating Smith-Purcell Emission with Babinet Metasurfaces

    NASA Astrophysics Data System (ADS)

    Wang, Zuojia; Yao, Kan; Chen, Min; Chen, Hongsheng; Liu, Yongmin

    2016-10-01

    Swift electrons moving closely parallel to a periodic grating produce far-field radiation of light, which is known as the Smith-Purcell effect. In this letter, we demonstrate that designer Babinet metasurfaces composed of C -aperture resonators offer a powerful control over the polarization state of the Smith-Purcell emission, which can hardly be achieved via traditional gratings. By coupling the intrinsically nonradiative energy bound at the source current sheet to the out-of-plane electric dipole and in-plane magnetic dipole of the C -aperture resonator, we are able to excite cross-polarized light thanks to the bianisotropic nature of the metasurface. The polarization direction of the emitted light is aligned with the orientation of the C -aperture resonator. Furthermore, the efficiency of the Smith-Purcell emission from Babinet metasurfaces is significantly increased by 84%, in comparison with the case of conventional gratings. These findings not only open up a new way to manipulate the electron-beam-induced emission in the near-field region but also promise compact, tunable, and efficient light sources and particle detectors.

  3. Manipulating Smith-Purcell Emission with Babinet Metasurfaces.

    PubMed

    Wang, Zuojia; Yao, Kan; Chen, Min; Chen, Hongsheng; Liu, Yongmin

    2016-10-07

    Swift electrons moving closely parallel to a periodic grating produce far-field radiation of light, which is known as the Smith-Purcell effect. In this letter, we demonstrate that designer Babinet metasurfaces composed of C-aperture resonators offer a powerful control over the polarization state of the Smith-Purcell emission, which can hardly be achieved via traditional gratings. By coupling the intrinsically nonradiative energy bound at the source current sheet to the out-of-plane electric dipole and in-plane magnetic dipole of the C-aperture resonator, we are able to excite cross-polarized light thanks to the bianisotropic nature of the metasurface. The polarization direction of the emitted light is aligned with the orientation of the C-aperture resonator. Furthermore, the efficiency of the Smith-Purcell emission from Babinet metasurfaces is significantly increased by 84%, in comparison with the case of conventional gratings. These findings not only open up a new way to manipulate the electron-beam-induced emission in the near-field region but also promise compact, tunable, and efficient light sources and particle detectors.

  4. Understanding the output of a Smith-Root GPP electrofisher

    USGS Publications Warehouse

    Miranda, L.E.; Spencer, A.B.

    2005-01-01

    There is confusion among biologists about the use of the percent of range control in the GPP series of Smith-Root electrofishers. We evaluated the output of a GPP 7.5 electrofisher to examine how adjustments to the percent of range control affect voltage, pulse width, duty cycle, and waveform. We found that contrary to how most users interpret the labels on the GPP unit, adjustments to the percent of range control are linked only indirectly to changes in peak voltage. Suggestions for dealing with the restrictions of the GPP units are offered. ?? Copyright by the American Fisheries Society 2005.

  5. Smith Newton Vehicle Performance Evaluation - 1st Quarter 2014 (Brochure)

    SciTech Connect

    Not Available

    2014-04-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  6. Smith Newton Vehicle Performance Evaluation - Gen2 - 2013 (Brochure)

    SciTech Connect

    Not Available

    2014-04-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  7. Smith Newton Vehicle Performance Evaluation - Gen 2 - Cumulative (Brochure)

    SciTech Connect

    Not Available

    2014-08-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  8. Characteristics of Smith-Purcell radiation in millimeter wavelength region

    NASA Astrophysics Data System (ADS)

    Naumenko, G. A.; Potylitsyn, A. P.; Karataev, P.; Bleko, V.; Sukhikh, L. G.; Shevelev, M. V.; Popov, Yu

    2016-07-01

    Investigations of the Smith-Purcell radiation (SPR) were began with non-relativistic electron beams with some unexpected experimental results. Further the experimental investigations were performed with relativistic electron beams for application to beam diagnostics. Large discrepancy between different theoretical models significantly increases the role of experimental studies of this phenomenon. In this report we present some problems and features of experimental investigations of SPR in millimeter wavelength region. The problems of prewave zone and coherent effects are considered. The shadowing effect, focusing of radiation using a parabolic SPR target and effect of inclination of target strips were investigated with moderately relativistic electron beam.

  9. Boundaries and interfaces in materials: The David A. Smith symposium

    SciTech Connect

    Pond, R.C. . Dept. of Materials Science and Engineering); Clark, W.A.T. . Dept. of Materials Science and Engineering); King, A.H. . Dept. of Materials Science and Engineering); Williams, D.B. (Lehigh Univ., Bethlehem, PA (United States

    1998-01-01

    Just over a year ago David Smith died. Then the loss of a distinguished scientist and dedicated teacher was mourned. Now it is time to celebrate his accomplishments both as a scientist and teacher and this book serves as a reminder of his many contributions to the field of boundaries and interfaces. Researchers from ten countries contributed their work to the symposium, many of whom were former students of David from his years in Oxford. This emphasizes David's tremendous effect on the career of many established scientists through his role as both a teacher and an advisor. Separate abstracts were prepared for 38 papers in this book.

  10. Corrugated capillary as THz Cherenkov Smith-Purcell radiator

    NASA Astrophysics Data System (ADS)

    Lekomtsev, K. V.; Aryshev, A. S.; Tishchenko, A. A.; Ponomarenko, A. A.; Sukharev, V. M.; Terunuma, N.; Urakawa, J.; Strikhanov, M. N.

    2016-07-01

    In this article we discussed Particle In Cell electromagnetic simulations and mechanical design of dielectric capillaries that produce THz Cherenkov Smith-Purcell radiation (ChSPR), arising when a femtosecond electron multi-bunch beam propagates through corrugated and non-corrugated dielectric capillaries with metallic radiation reflectors. We investigated the influence of the four-bunch beam on the SPR field spectrum and on the ChSPR power spectrum, and the influence of the non-central beam propagation on the ChSPR power spectrum. We also discussed the design and assembly of the capillaries, constructed as sets of cylindrical rings.

  11. Kitchen surgery and house calls in old Fort Smith.

    PubMed

    Prewitt, Taylor

    2013-09-01

    Medical practice in the late nineteenth and early twentieth centuries consisted largely of kitchen surgery and house calls. The practices of Dr. St. Cloud Cooper and other Fort Smith doctors reflected the standards of practice in Arkansas and the nation as the principles of aseptic surgery gradually gained acceptance. The doctor's black bag used on house calls still lacked the effective agents which became available during the mid-twentieth century, leaving the physician to rely on personal inner resources in order to perform a useful service.

  12. STS-110 M.S. Smith suits up for TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-110 Mission Specialist Steven Smith relaxes during suit fit, which is part of Terminal Countdown Demonstration Test activities. The TCDT is held at KSC prior to each Space Shuttle flight to provide flight crews an opportunity to participate in simulated launch countdown activities. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  13. [Smith-Magenis syndrome: case report and review].

    PubMed

    Bronberg, Rubén; Ziembar, María; Drut, Mónica; Goldschmidt, Ernesto

    2008-04-01

    Smith-Magenis syndrome (SMS) is characterized by distinctive facial features that progress with age, developmental delay, cognitive impairment, and behavioral abnormalities associated with molecular anomaly in 17p11.2. Treatment includes: early childhood intervention programs, special education, vocational training later in life, and speech/language, physical, and occupational, behavioral, and sensory integration therapies. We report a 14-year-old girl with mental retardation, behavioral abnormalities and facial dysmorphism, with SMS diagnosis confirmed by cytogenetic analysis and in situ hydridization (FISH).

  14. Rapid and Reliable Binding Affinity Prediction of Bromodomain Inhibitors: A Computational Study

    PubMed Central

    2016-01-01

    Binding free energies of bromodomain inhibitors are calculated with recently formulated approaches, namely ESMACS (enhanced sampling of molecular dynamics with approximation of continuum solvent) and TIES (thermodynamic integration with enhanced sampling). A set of compounds is provided by GlaxoSmithKline, which represents a range of chemical functionality and binding affinities. The predicted binding free energies exhibit a good Spearman correlation of 0.78 with the experimental data from the 3-trajectory ESMACS, and an excellent correlation of 0.92 from the TIES approach where applicable. Given access to suitable high end computing resources and a high degree of automation, we can compute individual binding affinities in a few hours with precisions no greater than 0.2 kcal/mol for TIES, and no larger than 0.34 and 1.71 kcal/mol for the 1- and 3-trajectory ESMACS approaches. PMID:28005370

  15. Stability of seasonal influenza vaccines investigated by spectroscopy and microscopy methods.

    PubMed

    Patois, E; Capelle, M A H; Gurny, R; Arvinte, T

    2011-10-06

    The stability of different seasonal influenza vaccines was investigated by spectroscopy and microscopy methods before and after the following stress-conditions: (i) 2 and 4 weeks storage at 25°C, (ii) 1 day storage at 37°C and (iii) one freeze-thaw cycle. The subunit vaccine Influvac (Solvay Pharma) and the split vaccine Mutagrip (Sanofi Pasteur) were affected by all stresses. The split vaccine Fluarix (GlaxoSmithKline) was affected only by storage at 25°C. The virosomal vaccine Inflexal V (Berna Biotech) was stable after the temperature stresses but aggregated after one freeze-thaw cycle. This study provides new insights into commercial vaccines of low antigen concentration and highlights the importance of using multiple techniques to assess vaccine stability.

  16. Seroxat and the suppression of clinical trial data: regulatory failure and the uses of legal ambiguity.

    PubMed

    McGoey, L; Jackson, E

    2009-02-01

    This article critically evaluates the Medicines and Healthcare products Regulatory Agency's announcement, in March 2008, that GlaxoSmithKline would not face prosecution for deliberately withholding trial data, which revealed not only that Seroxat was ineffective at treating childhood depression but also that it increased the risk of suicidal behaviour in this patient group. The decision not to prosecute followed a four and a half year investigation and was taken on the grounds that the law at the relevant time was insufficiently clear. This article assesses the existence of significant gaps in the duty of candour which had been assumed to exist between drugs companies and the regulator, and reflects upon what this episode tells us about the robustness, or otherwise, of the UK's regulation of medicines.

  17. Antibody engineering and therapeutics conference

    PubMed Central

    Larrick, James W; Parren, Paul WHI; Huston, James S; Plückthun, Andreas; Bradbury, Andrew; Tomlinson, Ian M; Chester, Kerry A; Burton, Dennis R; Adams, Gregory P; Weiner, Louis M; Scott, Jamie K; Alfenito, Mark R; Veldman, Trudi; Reichert, Janice M

    2014-01-01

    The 25th anniversary of the Antibody Engineering & Therapeutics Conference, the Annual Meeting of The Antibody Society, will be held in Huntington Beach, CA, December 7–11, 2014. Organized by IBC Life Sciences, the event will celebrate past successes, educate participants on current activities and offer a vision of future progress in the field. Keynote addresses will be given by academic and industry experts Douglas Lauffenburger (Massachusetts Institute of Technology), Ira Pastan (National Cancer Institute), James Wells (University of California, San Francisco), Ian Tomlinson (GlaxoSmithKline) and Anthony Rees (Rees Consulting AB and Emeritus Professor, University of Bath). These speakers will provide updates of their work, placed in the context of the substantial growth of the industry over the past 25 years. PMID:25517297

  18. The FEBS Journal in 2016: read, reflect and don't feed the wolves.

    PubMed

    Martin, Seamus J

    2016-01-01

    Seamus Martin holds the Smurfit Chair of Medical Genetics at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland. He obtained his PhD with Tom Cotter at the National University of Ireland, followed by post-doctoral fellowships with Ivan Roitt at UCL, London, UK, and Doug Green at The La Jolla Institute for Allergy and Immunology, California, USA. He works on all aspects of cell death control and is especially interested in the links between apoptosis, necrosis and inflammation. He received the GlaxoSmithKline Award of The Biochemical Society for his work on unravelling the caspase activation cascade and was elected to the Royal Irish Academy in 2006 and EMBO in 2009. He has been the Editor-in-Chief of The FEBS Journal since 2014.

  19. Antibody engineering and therapeutics conference. The annual meeting of the antibody society, Huntington Beach, CA, December 7-11, 2014.

    PubMed

    Larrick, James W; Parren, Paul W H I; Huston, James S; Plückthun, Andreas; Bradbury, Andrew; Tomlinson, Ian M; Chester, Kerry A; Burton, Dennis R; Adams, Gregory P; Weiner, Louis M; Scott, Jamie K; Alfenito, Mark R; Veldman, Trudi; Reichert, Janice M

    2014-01-01

    The 25th anniversary of the Antibody Engineering & Therapeutics Conference, the Annual Meeting of The Antibody Society, will be held in Huntington Beach, CA, December 7-11, 2014. Organized by IBC Life Sciences, the event will celebrate past successes, educate participants on current activities and offer a vision of future progress in the field. Keynote addresses will be given by academic and industry experts Douglas Lauffenburger (Massachusetts Institute of Technology), Ira Pastan (National Cancer Institute), James Wells (University of California, San Francisco), Ian Tomlinson (GlaxoSmithKline) and Anthony Rees (Rees Consulting AB and Emeritus Professor, University of Bath). These speakers will provide updates of their work, placed in the context of the substantial growth of the industry over the past 25 years.

  20. Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure-Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents.

    PubMed

    Pieroni, Marco; Azzali, Elisa; Basilico, Nicoletta; Parapini, Silvia; Zolkiewski, Michal; Beato, Claudia; Annunziato, Giannamaria; Bruno, Agostino; Vacondio, Federica; Costantino, Gabriele

    2017-03-09

    Malaria eradication is a global health priority, but current therapies are not always suitable for providing a radical cure. Artemisinin has paved the way for the current malaria treatment, the so-called Artemisinin-based Combination Therapy (ACT). However, with the detection of resistance to ACT, innovative compounds active against multiple parasite species and at multiple life stages are needed. GlaxoSmithKline has recently disclosed the results of a phenotypic screening of an internal library, publishing a collection of 400 antimalarial chemotypes, termed the "Malaria Box". After analysis of the data set, we have carried out a medicinal chemistry campaign in order to define the structure-activity relationships for one of the released compounds, which embodies a benzothiophene-2-carboxamide core. Thirty-five compounds were prepared, and a description of the structural features responsible for the in vitro activity against different strains of P. falciparum, the toxicity, and the metabolic stability is herein reported.

  1. The Safety of Adjuvanted Vaccines Revisited: Vaccine-Induced Narcolepsy.

    PubMed

    Ahmed, S Sohail; Montomoli, Emanuele; Pasini, Franco Laghi; Steinman, Lawrence

    2016-01-01

    Despite the very high benefit-to-risk ratio of vaccines, the fear of negative side effects has discouraged many people from getting vaccinated, resulting in the reemergence of previously controlled diseases such as measles, pertussis and diphtheria. This fear has been amplified more recently by multiple epidemiologic studies that confirmed the link of an AS03-adjuvanted pandemic influenza vaccine (Pandemrix, GlaxoSmithKline Biologicals, Germany) used in Europe during the 2009 H1N1 influenza pandemic [A(H1N1) pdm09] with the development of narcolepsy, a chronic sleep disorder, in children and adolescents. However, public misperceptions of what adjuvants are and why they are used in vaccines has created in some individuals a closed "black box" attitude towards all vaccines. The focus of this review article is to revisit this "black box" using the example of narcolepsy associated with the European AS03-adjuvanted pandemic influenza vaccine.

  2. An ECLIPSE View of Alpha-1 Antitrypsin Deficiency.

    PubMed

    Lomas, David A

    2016-08-01

    Chronic obstructive pulmonary disease (COPD) is a multicomponent condition that is estimated to become the third leading cause of death in 2020. The ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints) study, funded by GlaxoSmithKline, is an observational study designed to define outcomes that can be used as endpoints in clinical trials in individuals with COPD. It allowed us to describe the heterogeneity of COPD, the stability of the exacerbation phenotype, and the factors associated with a progressive decline in lung function and the progression of emphysema on computed tomography scans. The cohort was also used to define genetic factors and biomarkers associated with COPD and disease progression. This review considers how the results from ECLIPSE can inform our understanding of the lung disease associated with alpha-1 antitrypsin deficiency.

  3. Obtaining real-world evidence: the Salford Lung Study

    PubMed Central

    New, John P; Bakerly, Nawar Diar; Leather, David; Woodcock, Ashley

    2014-01-01

    We need to assess clinical treatments in real-life settings outside of randomised controlled trials (RCTs). Pragmatic RCT (pRCT) data can supplement RCTs by providing effectiveness information to support healthcare decisions. Electronic health records can facilitate concurrent safety monitoring and data collection without direct patient contact for large randomised study populations in pRCTs. The Salford Lung Study is the world's first phase III pRCT in asthma and chronic obstructive pulmonary disease (COPD), which aims to randomise over 7000 patients. This paper describes the hurdles overcome and the enormous effort and resource required to establish this comparative effectiveness study of a prelicence intervention. GlaxoSmithKline protocol HZC115151 Asthma study clinicaltrials.gov registration NCT01706198 COPD study clinicaltrials.gov registration NCT01551758 PMID:24603195

  4. Updated recommendations for use of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine in adults aged 65 years and older - Advisory Committee on Immunization Practices (ACIP), 2012.

    PubMed

    2012-06-29

    Since 2005, the Advisory Committee on Immunization Practices (ACIP) has recommended a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine booster dose for all adolescents aged 11 through 18 years (preferred at 11 through 12 years) and for those adults aged 19 through 64 years who have not yet received a dose. In October 2010, despite the lack of an approved Tdap vaccine for adults aged 65 years and older, ACIP recommended that unvaccinated adults aged 65 years and older be vaccinated with Tdap if in close contact with an infant, and that other adults aged 65 years and older may receive Tdap. In July 2011, the Food and Drug Administration (FDA) approved expanding the age indication for Boostrix (GlaxoSmithKline Biologicals, Rixensart, Belgium) to aged 65 years and older. In February 2012, ACIP recommended Tdap for all adults aged 65 years and older. This recommendation supersedes previous Tdap recommendations regarding adults aged 65 years and older.

  5. Use of MenACWY-CRM in adolescents in the United States.

    PubMed

    Black, Steven; Block, Stan L

    2013-03-01

    Adolescents constitute a high-risk group for invasive meningococcal disease. MenACWY-CRM (Menveo, Novartis Vaccines, Cambridge, MA) is a quadrivalent meningococcal conjugate vaccine indicated to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroups A, C, W-135, and Y. It has been approved for use in persons age 2-55 years. The tolerability and immunogenicity of MenACWY-CRM in adolescents have been ascertained in phase 2 and 3 trials against MPSV4 (Menomune, sanofi pasteur, Swiftwater, PA), an unconjugated quadrivalent meningococcal vaccine, and MenACWY-D (Menactra, sanofi pasteur), another conjugated quadrivalent meningococcal vaccine. Clinical trials also have demonstrated that MenACWY-CRM is well tolerated and immunogenic when administered to adolescents concomitantly with the combined tetanus, diphtheria, and acellular pertussis vaccine (Boostrix, GlaxoSmithKline Biologicals, Rixensart, Belgium) and the quadrivalent human papillomavirus vaccine (Gardasil, Merck & Co., Inc., Whitehouse Station, NJ).

  6. Approaches to understanding the searching behavior of CrossFire users.

    PubMed

    Cooke, Frank; Kopelev, Nikolai; Schofield, Helen; Boyce, Geraldine; Dunne, Sean

    2002-01-01

    Due to the high costs of purchasing, supporting and training users of desktop chemical information systems, it is important to understand users' behavior in order that deficiencies in their search efficiency and effectiveness can be identified and addressed. CrossFire generates comprehensive log files that can be examined to determine the nature of search activity. At GSK (GlaxoSmithKline) a Log File Parser, CrossParse, has been developed in Visual Basic that enables analysis by individual user name, groups of users or the whole user population. Log files can be analyzed for occasions when specific structural features are built, specific types of search are done and how the results are manipulated. CrossParse produces output that can be saved and analyzed within Microsoft Excel. It also allows determination of numbers of active concurrent users on the CrossFire system. CrossParse has been used at GSK (ex-SmithKline Beecham sites) to examine the search behavior of medicinal and synthetic chemists. Additionally, it has been used by MIMAS (Manchester Information and Associated Services) to compare the search behavior of trained and untrained users in the higher education community and to identify any areas where improvements to training can be made. Use of CrossParse in both organizations has allowed identification of areas where users may have difficulties using CrossFire. This will provide valuable feedback to MDL Inc., the authors of the CrossFire application, and guide them in enhancing CrossFire.

  7. The development of Lapdap, an affordable new treatment for malaria.

    PubMed

    Lang, Trudie; Greenwood, Brian

    2003-03-01

    There is much discussion on how new drugs can be developed for use in developing countries at a price that makes them accessible to those who need them most. The development of a new antimalarial, chlorproguanil/dapsone (Lapdap), provides an example of a way this can be achieved. The idea of combining chlorproguanil with dapsone came from studies done in east Africa in the 1980s. These studies showed, both in vivo and in vitro, that chlorproguanil/dapsone had advantages over sulphadoxine/pyrimethamine. A public-private partnership was established subsequently to manage a development programme of a fixed ratio tablet of this drug combination. The partnership comprised GlaxoSmithKline (formerly SmithKline Beecham), the World Health Organization (WHO), and the UK's Department for International Development (DFID). All clinical, toxicological, and pharmaceutical chemistry studies are complete and the findings have been submitted for regulatory approval. The question now is how Lapdap might be used safely and appropriately if it receives regulatory approval. A public-health group has been formed by WHO (with funding from DFID and the Gates Foundation) to research into this issue. The Lapdap development team completed its objective of submitting Lapdap for drug registration within a period of 5 years and at a low cost. Experience with the development of Lapdap may provide a model for the introduction of other new drugs developed primarily for use in developing countries.

  8. The futility of utility: how market dynamics marginalize Adam Smith

    NASA Astrophysics Data System (ADS)

    McCauley, Joseph L.

    2000-10-01

    Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to nonintegrable dynamics when production/investment are accounted for, resolving Mirowski's thesis. Price as a function of demand does not exist mathematically either. All equilibria are unstable. I then explain how deterministic chaos can be distinguished from random noise at short times. In the generalization to liquid markets and finance theory described by stochastic excess demand dynamics, I also show the following. Market price distributions cannot be rescaled to describe price movements as ‘equilibrium’ fluctuations about a systematic drift in price. Utility maximization does not describe equilibrium. Maximization of the Gibbs entropy of the observed price distribution of an asset would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real, liquid markets (stocks, bonds, foreign exchange). There are three inconsistent definitions of equilibrium used in economics and finance, only one of which is correct. Prices in unregulated free markets are unstable against both noise and rising or falling expectations: Adam Smith's stabilizing invisible hand does not exist, either in mathematical models of liquid market data, or in real market data.

  9. [Inborn error of cholesterol biosynthesis: Smith-Lemli-Opitz syndrome].

    PubMed

    Koczok, Katalin; V Oláh, Anna; P Szabó, Gabriella; Oláh, Éva; Török, Olga; Balogh, István

    2015-10-18

    Smith-Lemli-Opitz syndrome is an autosomal recessive mental retardation and multiple malformation syndrome caused by deficiency of the 7-dehydrocholesterol reductase, the enzyme catalyzing the last step in cholesterol biosynthesis. The authors summarize the pathophysiology, epidemiology, clinical picture, diagnostics and therapy of the disease based on a review of the international literature. Since 2004, fourteen patients have been diagnosed with Smith-Lemli-Opitz syndrome in Hungary, which suggests an underdiagnosis of the disease based upon estimated incidence data. Due to deficiency of the 7-dehydrocholesterol reductase, serum cholesterol concentration is low and 7-dehydrocholesterol concentration is elevated in blood and tissues; the latter being highly specific for the syndrome. Detection of disease-causing mutations makes the prenatal diagnosis possible. The clinical spectrum is wide, the most common symptom is syndactyly of the second and third toes. Standard therapy is cholesterol supplementation. Recent publications suggest that oxidative compounds of 7-dehydrocholesterol may play a role in the pathophysiology of the disease as well.

  10. STS-103 Mission Specialist Smith suits up before launch

    NASA Technical Reports Server (NTRS)

    1999-01-01

    After donning his launch and entry suit, sts-103 Mission Specialist Steven L. Smith shows a positive attitude over the second launch attempt for Space Shuttle Discovery. The previous launch attempt on Dec. 17 was scrubbed about 8:52 p.m. due to numerous violations of weather launch commit criteria at KSC. Smith and other crew members Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Claude Nicollier of Switzerland and Jean-Francois Clervoy of France are scheduled to lift off at 7:50 p.m. EST Dec. 19 on mission STS-103, servicing the Hubble Space Telescope. Objectives for the nearly eight-day mission include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Discovery is expected to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST.

  11. Valacyclovir for the treatment of genital herpes.

    PubMed

    Brantley, Julie S; Hicks, Lindsey; Sra, Karan; Tyring, Stephen K

    2006-06-01

    Genital herpes is the most prevalent sexually transmitted infection in the USA. While sometimes mild in severity, it can be a distressing and painful chronic condition. Likewise, herpes labialis and herpes zoster can be both physically and psychologically painful. While there is no cure for these conditions, treatment to alleviate symptoms, suppress recurrences and reduce transmission has been drastically improved over the past 20 years with the use of guanine nucleoside antivirals, such as valacyclovir hydrochloride (Valtrex), GlaxoSmithKline) the highly bioavailable prodrug of acyclovir (Zovirax((R)), GlaxoSmithKline), and famciclovir (Famvir, Novartis), a highly bioavailable prodrug of penciclovir (Denavir, Novartis). Clinical trials involving approximately 10,000 patients (including patients from nongenital herpes studies, such as herpes zoster) have assessed the safety and efficacy of valacyclovir in the treatment of initial genital herpes outbreaks, episodic treatment of recurrent episodes and daily suppressive therapy. It was shown that valacyclovir has similar efficacy to acyclovir in the episodic and suppressive treatment of genital herpes. Valacyclovir is the only antiviral drug approved for a once-daily dose of suppressive therapy for genital herpes, as well as the only antiviral drug US FDA approved for a 3-day regimen of episodic treatment of recurrent genital herpes. In addition, valacyclovir is also indicated in the reduction of the sexual transmission of herpes simplex virus infection and for the treatment of herpes labialis. In herpes zoster, valacyclovir is more effective than acyclovir or placebo (and as equally effective as famciclovir) in shortening the length and severity of herpes zoster-associated pain and postherpetic neuralgia. Valacyclovir has an acceptable safety profile in patients with herpes simplex and herpes zoster. The less frequent dosing regimen makes it an attractive option in the treatment of genital herpes and other viral

  12. Development and clinical testing of multivalent vaccines based on a diphtheria-tetanus-acellular pertussis vaccine: difficulties encountered and lessons learned.

    PubMed

    Capiau, Carine; Poolman, Jan; Hoet, Bernard; Bogaerts, Hugues; Andre, Francis

    2003-06-02

    The widespread use of whole-cell pertussis vaccines in the second half of the 20th century have reduced the incidence of the disease significantly. However, in some countries, concerns about the reactogenicity and potential neurological damage associated with whole-cell vaccines led to a decrease in vaccine acceptance and an increase in morbidity and mortality of pertussis in several countries. This prompted the development of less reactogenic acellular pertussis vaccines combined with diphtheria and tetanus toxoids, initially in Japan and later in other countries. In Europe, the improved diphtheria, tetanus and acellular pertussis (DTPa) vaccine was first introduced in March 1994. The pertussis component of this DTPa vaccine, developed by Glaxo SmithKline, consists of pertussis toxoid, filamentous haemagglutinin and pertactin. The vaccine is well tolerated, with a lower incidence of adverse reactions than after administration of whole-cell vaccines. The long-lasting efficacy and effectiveness of DTPa vaccines have been extensively documented and these are now the cornerstone of a large range of combined vaccines including DTPa-hepatitis B (HBV), DTPa-inactivated polio (IPV) and DTPa-HBV-IPV. A lyophilised Haemophilus influenzae type b (Hib) vaccine can be reconstituted with all of these liquid combinations. The introduction of well-tolerated and efficacious DTPa vaccines and their more polyvalent combinations has improved the acceptance and simplified the implementation of childhood immunisation. This paper is a review of the technical and scientific difficulties encountered and the lessons learned over the 10-year period that it took to develop and introduce six multivalent vaccines using the Glaxo SmithKline DTPa as a building block.

  13. Immune memory to hepatitis B persists in children aged 7-8 years, who were vaccinated in infancy with 4 doses of hexavalent DTPa-HBV-IPV/Hib (Infanrix™ hexa) vaccine.

    PubMed

    Van Der Meeren, Olivier; Bleckmann, Gerhard; Crasta, Priya D

    2014-01-01

    Protection against hepatitis B disease relies on either protective serum antibodies or on the ability of the immune system to mount an anamnestic response when confronted with the hepatitis B virus (HBV). This open multicenter study (EUDRACT: 2010-022538-10) measured antibodies to HBV surface antigen (anti-HBs) in 7-8-year-old children who had received 4 doses of hexavalent diphtheria-tetanus-acellular pertussis-HBV-inactivated poliovirus-Hemophilus influenzae type b conjugate vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa; GlaxoSmithKline Vaccines) in the first 2 years of life through routine vaccine services in Germany. The ability of these children to mount an anamnestic response to a challenge dose of monovalent HBV vaccine (Engerix™ B Kinder; GlaxoSmithKline Vaccines) was also assessed. Before the challenge dose, 78.5% of children had anti-HBs levels ≥6.2 mIU/mL (seropositive) and 72.2% had anti-HBs levels ≥10 mIU/mL (seroprotected). Post-challenge, 98.9% had anti-HBs levels ≥10 mIU/mL and 95.8% had anti-HBs ≥100 mIU/mL. An anamnestic response to the challenge was observed in 96.6% of all subjects. The challenge dose was well tolerated, with a reactogenicity and safety profile consistent with published data. DTPa-HBV-IPV/Hib induces long-lasting immune memory to HBV that appears very similar to that induced by monovalent HBV vaccines. Protection against hepatitis B may be conferred through immune memory in subjects who responded to primary vaccination, even when they subsequently lose detectable levels of circulating anti-HBs antibodies.

  14. Immunological persistence in 5 y olds previously vaccinated with hexavalent DTPa-HBV-IPV/Hib at 3, 5, and 11 months of age.

    PubMed

    Silfverdal, Sven A; Assudani, Deepak; Kuriyakose, Sherine; Van Der Meeren, Olivier

    2014-01-01

    The combined diphtheria-tetanus-acellular pertussis-hepatitis B-poliomyelitis/Haemophilus influenza vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa, GlaxoSmithKline Vaccines) is used for primary vaccination of infants in a range of schedules world-wide. Antibody persistence after 4 DTPa-HBV-IPV/Hib doses in the first 2 y of life has been documented, but long-term persistence data following the 3, 5, 11-12 months (3-5-11) infant vaccination schedule, employed for example in Nordic countries, are limited. We assessed antibody persistence in 57 5-year-old children who had received either DTPa-HBV-IPV/Hib or DTPa-IPV/Hib (Infanrix™-IPV/Hib, GlaxoSmithKline Vaccines) in the 3-5-11 schedule. Among DTPa-HBV-IPV/Hib recipients, 7/12 retained seroprotective antibody concentrations for diphtheria, 10/12 for tetanus, 5/12 for hepatitis and 10/12 for Hib. Detectable antibodies were observed for 0/12 children for pertussis toxin (PT), 12/12 for filamentous haemagglutinin (FHA) and 8/12 for pertactin (PRN). Among DTPa-IPV/Hib recipients, 28/45 retained seroprotective anti-diphtheria concentrations, 34/44 for tetanus and 40/45 for Hib. Detectable antibodies were observed for 9/45 children for PT, 41/45 for FHA and 34/45 for PRN. Antibody persistence in DTPa-HBV-IPV/Hib and DTPa-IPV/Hib-vaccinees appeared similar in 5 y olds to that previously observed in children of a similar age who had received 4 prior doses of DTPa-HBV-IPV/Hib (or DTPa-IPV/Hib). As in subjects primed with 4 prior doses, we observed that antibodies markedly declined by 5 y of age, calling for the administration of a pre-school booster dose in order to ensure continued protection against pertussis.

  15. Obituary: Harding Eugene (Gene) Smith, Jr., 1947-2007

    NASA Astrophysics Data System (ADS)

    Lonsdale, Carol; Soifer, Tom

    2009-01-01

    Harding Eugene Smith Junior, or Gene, as he was known to family, friends, and colleagues, passed away after an automobile accident in Encinitas, California, on 16 August 2007. He was 60 years old. Gene had recently retired from UCSD after thirty years of service. A memorial service was held at Quail Botanical Gardens in Encinitas, California, on 23 August 2007. A web page is dedicated to his memory at http://harding.smith.muchloved.com, where contributions of memories are invited. Gene was born in San Jose, California in 1947, to Harding Eugene Smith Senior, and Bernice Smith (nee Smith). Harding Smith Senior was an air-force navigator; therefore Gene spent his childhood moving from one air-force base to another. Although an only child, Gene was very close to his cousin Meg, whom he lived nearby to in Gilroy for a time, and the two were like brother and sister. The elder Harding Smith was lost in action over Cambodia in the mid-sixties. Gene was a dedicated student, a boy scout, and a Presidential Scholar. He majored in Physics at Caltech, where he also took a lively interest in the football team and the Glee Club, and was elected a House Officer. To his close friends, he was known at Caltech as Smitty, and the closest of them was Rob Drew, who gave a glimpse into that period of Gene's life at the memorial: "Gene arrived early at campus his first year, in response to an invitation to join the football team. Gene's size and features reminded the head coach of a long-forgotten player named 'Johnson.' After a few days of confusion, Gene simply replaced the name on his helmet. 'Johnson!' coach would yell, 'get in there!' If Johnson was going to get to play, Gene was going to be the best Johnson available!" Gene spent the summer of 1966 working at Kitt Peak, where his lifetime love of observing with ground-based telescopes began, though he learned some things the hard way, such as the fact that trying to squeeze 40,000 numbers onto a computer that stored only 32

  16. Dyadic Power Theory, Touch, and Counseling Psychology: A Response to Smith, Vogel, Madon, and Edwards (2011)

    ERIC Educational Resources Information Center

    Dunbar, Norah E.; Abra, Gordon

    2012-01-01

    Smith, Vogel, Madon, and Edwards' (2011) recent article tested dyadic power theory (DPT) by examining the use of touch as a compliance-gaining tactic in the conflicts of married couples. In this response, we raise a methodological issue about the touch behaviors examined by Smith et al. and also pose a theoretical critique that their test of DPT…

  17. Unconscious Odour Conditioning 25 Years Later: Revisiting and Extending "Kirk-Smith, Van Toller and Dodd"

    ERIC Educational Resources Information Center

    Zucco, Gesualdo M.; Paolini, Michela; Schaal, Benoist

    2009-01-01

    The pioneering work by Kirk-Smith, Van Toller, and Dodd [Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. (1983). "Unconscious odour conditioning in human subjects." "Biological Psychology," 17, 221-231], established that an unnoticed odorant paired with an emotionally meaningful task can influence mood and attitudes when the odorant alone is…

  18. An Alternative View of the Instructional Design Process: A Response to Smith and Boling

    ERIC Educational Resources Information Center

    Gibbons, Andrew S.; Yanchar, Stephen C.

    2010-01-01

    A recent literature review by Smith and Boling (2009) critically examines the received view of instructional design in educational technology. Smith and Boling conclude that the foundational literature characterizes design in a way that leads to a constrained understanding of design, especially by novices. They suggest that as a field we move…

  19. Speech/Language Pathologists Reflect on Sally Smith and the Lab School of Washington

    ERIC Educational Resources Information Center

    Learning Disabilities: A Multidisciplinary Journal, 2010

    2010-01-01

    Sally L. Smith had a clear vision of how she thought speech and language services should be integrated into her school, The Lab School of Washington. It was Smith's idea that language therapists should work individually with students to help them make gains in their particular areas of need, as well as to work collaboratively with the teachers,…

  20. 2. VIEW OF THE SMITH NO.3 SITE ARE TO THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF THE SMITH NO.3 SITE ARE TO THE NORTHEAST. THE BLACKSMITH/MINE CAR REPAIR SHOP IS LEFT CENTER. THE PROCESSING PLANT AND TIPPLE ARE RIGHT CENTER. - Smith Mine, Bear Creek 1.5 miles West of Town of Bear Creek, Red Lodge, Carbon County, MT

  1. Denial and Defensiveness in the Place of Fact and Reason: Rejoinder to Smith and Lovass.

    ERIC Educational Resources Information Center

    Gresham, Frank M.; MacMillan, Donald L.

    1997-01-01

    Responds to "The UCLA Young Autism Project: A Reply to Gresham and MacMillan" (Smith and Lovaas), which criticized a review questioning the effectiveness of an intervention for children with autism. The Smith and Lovass article is described as defensive, factually inaccurate, and as not adequately addressing the question of external validity.…

  2. Rhetorical Studies: A Reassessment of Adam Smith's Lectures on Rhetoric and Belles Lettres.

    ERIC Educational Resources Information Center

    Purcell, William M.

    1986-01-01

    Offers a dissenting interpretation of Adam Smith's Lectures on Rhetoric and Belles Lettres and a more conservative perspective on Smith's significance to the history of rhetorical theory. Views the lectures as an historical commentary on literature and rhetoric from the perspective of an eighteenth-century lecturer. (JD)

  3. Two Rival Conceptions of Vocational Education: Adam Smith and Friedrich List.

    ERIC Educational Resources Information Center

    Winch, Christopher

    1998-01-01

    Examines and discusses two views of political economy: (1) the classical model of Adam Smith; and (2) the social capitalist model associated with Friedrich List. Explores two varieties of vocational education and training that emerge from a comparison of Smith's and List's ideas. (CMK)

  4. How To Survive in Postindustrial Environments: Adam Smith's Advice for Today's Colleges and Universities.

    ERIC Educational Resources Information Center

    Ortmann, Andreas

    1997-01-01

    Adam Smith's discussion of the payment modes of teachers and resulting consequences for the quality of teaching and process of curricular innovation are reviewed through the conceptual lens of modern agency theory. Smith's analysis of higher education in his day (eighteenth century) sheds light on faculty incentive and assessment problems that…

  5. Robert Lloyd Smith: A Black Lawmaker in the Shadow of Booker T. Washington.

    ERIC Educational Resources Information Center

    Pitre, Merline

    1985-01-01

    Presents a biographical profile of Robert Lloyd Smith, a black Texas legislator of the 1890's. Discusses Smith's philosophy of self-improvement and economic self-sufficiency; his relationship with Booker T. Washington; his involvement in legislation regarding black education, civil rights, and agriculture; and the problems he faced in being a…

  6. VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF H.M. CAMP SMITH RECREATIONAL AREA, WITH MANANA HOUSING AREA IN THE FAR LEFT DISTANCE. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Intersection of Acacia Road and Brich Circle, Pearl City, Honolulu County, HI

  7. A Helping Hand in the Frederick Community—Ross Smith | Poster

    Cancer.gov

    By day, Ross Smith is the compliance and security officer for Data Management Services, Inc., assigned to the National Cancer Institute (NCI) at Frederick. His role is to ensure the secure operation of in-house computer systems, servers, and network connections. But in his spare time, Smith is also a volunteer firefighter and emergency medical technician (EMT).

  8. From the Barrio to the Bucolic: The Student Transfer Experience from Hsis to Smith College

    ERIC Educational Resources Information Center

    Wolf-Wendel, Lisa; Twombly, Susan; Morphew, Christopher; Sopcich, Joseph

    2004-01-01

    The study reported in this article examined two Hispanic-serving institutions, Miami-Dade Community College and Santa Monica College, and the innovative transfer agreements they have with Smith College, a highly selective private women's college. Factors that influence the successful transfer of women students to Smith from these HSIs are…

  9. 78 FR 2295 - Charlissa C. Smith; Establishment of Atomic Safety and Licensing Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ... COMMISSION Charlissa C. Smith; Establishment of Atomic Safety and Licensing Board Pursuant to delegation by... and Licensing Board (Board) is being established to preside over the following proceeding: Charlissa C... Charlissa C. Smith, dated December 5, 2012, challenging a denial letter from the Office of Nuclear...

  10. The nature of social preference and interactions in Smith-Magenis syndrome.

    PubMed

    Wilde, Lucy; Silva, Daniel; Oliver, Chris

    2013-12-01

    This natural observation study was designed to evaluate hypothesized elevated 'attention-seeking' and preference for adult attention in Smith-Magenis syndrome. Ten children with Smith-Magenis syndrome were observed across one school day, together with an age matched sample of 10 children with Down syndrome. Levels of attention given to, and vigilance for, adults and peers were recorded and compared. Sequences of behaviour were analyzed to evaluate the temporal relationships between giving and receiving attention during adult-child interactions. Compared to children with Down syndrome, children with Smith-Magenis syndrome gave preferential attention to adults and looked towards adults significantly more than they looked towards peers. Sequential analyses revealed that while children with Smith-Magenis syndrome did not initiate interactions with adults more than children with Down syndrome did, reciprocity between child and adult social behaviours in Smith-Magenis syndrome within interactions was compromised. This less synchronous sequence of child and adult interactions in Smith-Magenis syndrome may be the result of children with Smith-Magenis syndrome attempting to initiate interaction at times when it is unavailable. The marked preference for interacting with adults over peers in Smith-Magenis syndrome indicates atypicality of social interaction in this syndrome.

  11. The Behavioural Phenotype of Smith-Magenis Syndrome: Evidence for a Gene-Environment Interaction

    ERIC Educational Resources Information Center

    Taylor, L.; Oliver, C.

    2008-01-01

    Background: Behaviour problems and a preference for adult contact are reported to be prominent in the phenotype of Smith-Magenis syndrome. In this study we examined the relationship between social interactions and self-injurious and aggressive/disruptive behaviour in Smith-Magenis syndrome to explore potential operant reinforcement of problem…

  12. A Disciplinary Immigrant. Alexander Smith at the University of Chicago, 1894-1911

    ERIC Educational Resources Information Center

    Cotter, Donald

    2008-01-01

    The publication in 1906 of Alexander Smith's "Introduction to general inorganic chemistry" inaugurated a decisive change in chemical pedagogy in the US, the effects of which are still evident. The nature and extent of Smith's innovations are described through a comparison of his text to its source material and contemporaries. His…

  13. Smith Receives 2008 Walter Sullivan Award for Excellence in Science Journalism-Features

    NASA Astrophysics Data System (ADS)

    Williams, Robyn; Smith, Richard

    2008-07-01

    Richard Smith received the Walter Sullivan Award at the 2008 Joint Assembly Honors Ceremony, which was held on 29 May 2008 in Fort Lauderdale, Fla. Smith was honored for the documentary film ``Crude,'' which examines oil's ancient origins and the geology of its formation and explores the potential, unwelcome consequences of oil's prodigious use by industrial society as a fuel and raw material.

  14. Smith-Purcell radiation emission in aperiodic arrays

    NASA Astrophysics Data System (ADS)

    Saavedra, J. R. M.; Castells-Graells, D.; García de Abajo, F. Javier

    2016-07-01

    We study the Smith-Purcell light emission produced by electrons moving parallel to linear aperiodic particle arrays. This constitutes a generalization of this type of phenomenon from periodic to aperiodic structures. As in the periodic case, the emission is found to exhibit intense features in its angular and frequency distributions, associated with the condition of constructive interference between the contributions arising from different particles in the array. This condition can also be expressed in terms of momentum conservation involving reciprocal wave-vector transfers from the array. We consider two examples of quasiperiodic and hyperuniform aperiodic arrays that allow us to illustrate this idea. Our study provides insight into the interaction of fast electrons with aperiodic arrays characterized by strong features in reciprocal space, which dominate the electron-array coupling.

  15. ULTRA-SHARP solution of the Smith-Hutton problem

    NASA Technical Reports Server (NTRS)

    Leonard, B. P.; Mokhtari, Simin

    1992-01-01

    Highly convective scalar transport involving near-discontinuities and strong streamline curvature was addressed in a paper by Smith and Hutton in 1982, comparing several different convection schemes applied to a specially devised test problem. First order methods showed significant artificial diffusion, whereas higher order methods gave less smearing but had a tendency to overshoot and oscillate. Perhaps because unphysical oscillations are more obvious than unphysical smearing, the intervening period has seen a rise in popularity of low order artificially diffusive schemes, especially in the numerical heat transfer industry. The present paper describes an alternate strategy of using non-artificially diffusive high order methods, while maintaining strictly monotonic transitions through the use of simple flux limited constraints. Limited third order upwinding is usually found to be the most cost effective basic convection scheme. Tighter resolution of discontinuities can be obtained at little additional cost by using automatic adaptive stencil expansion to higher order in local regions, as needed.

  16. Mission Specialist Smith is suited and ready for launch

    NASA Technical Reports Server (NTRS)

    1999-01-01

    In the Operations and Checkout Building, STS-103 Mission Specialist Steven L. Smith signals he is suited up and ready for launch. Other crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly and Mission Specialists C. Michel Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Jean-Frangois Clervoy of France and Claude Nicollier of Switzerland. Clervoy and Nicollier are with the European Space Agency. The STS-103 mission, to service the Hubble Space Telescope, is scheduled for launch Dec. 17 at 8:47 p.m. EST from Launch Pad 39B. Mission objectives include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. After the 8-day, 21-hour mission, Discovery is expected to land at KSC Sunday, Dec. 26, at about 6:30 p.m. EST.

  17. Normal IQ is possible in Smith-Lemli-Opitz syndrome.

    PubMed

    Eroglu, Yasemen; Nguyen-Driver, Mina; Steiner, Robert D; Merkens, Louise; Merkens, Mark; Roullet, Jean-Baptiste; Elias, Ellen; Sarphare, Geeta; Porter, Forbes D; Li, Chumei; Tierney, Elaine; Nowaczyk, Małgorzata; Freeman, Kurt A

    2017-03-27

    Children with Smith-Lemli-Opitz syndrome (SLOS) are typically reported to have moderate to severe intellectual disability. This study aims to determine whether normal cognitive function is possible in this population and to describe clinical, biochemical and molecular characteristics of children with SLOS and normal intelligent quotient (IQ). The study included children with SLOS who underwent cognitive testing in four centers. All children with at least one IQ composite score above 80 were included in the study. Six girls, three boys with SLOS were found to have normal or low-normal IQ in a cohort of 145 children with SLOS. Major/multiple organ anomalies and low serum cholesterol levels were uncommon. No correlation with IQ and genotype was evident and no specific developmental profile were observed. Thus, normal or low-normal cognitive function is possible in SLOS. Further studies are needed to elucidate factors contributing to normal or low-normal cognitive function in children with SLOS.

  18. The analysis of convolutional codes via the extended Smith algorithm

    NASA Technical Reports Server (NTRS)

    Mceliece, R. J.; Onyszchuk, I.

    1993-01-01

    Convolutional codes have been the central part of most error-control systems in deep-space communication for many years. Almost all such applications, however, have used the restricted class of (n,1), also known as 'rate 1/n,' convolutional codes. The more general class of (n,k) convolutional codes contains many potentially useful codes, but their algebraic theory is difficult and has proved to be a stumbling block in the evolution of convolutional coding systems. In this article, the situation is improved by describing a set of practical algorithms for computing certain basic things about a convolutional code (among them the degree, the Forney indices, a minimal generator matrix, and a parity-check matrix), which are usually needed before a system using the code can be built. The approach is based on the classic Forney theory for convolutional codes, together with the extended Smith algorithm for polynomial matrices, which is introduced in this article.

  19. Deaf Smith County noise analysis: Revision 2. [Contains glossary

    SciTech Connect

    Not Available

    1985-11-01

    An analysis of activities proposed for the three major phases of development of the proposed nuclear waste repository site in Deaf Smith County, Texas, was conducted to quantify the noise levels and the effect of noise resulting from these activities. The report provides additional details of the predictive noise level modeling conducted for the site characterization, repository construction, and repository operation phases. Equivalent day/night sound levels are presented for each phase as sound level contours. Sound levels from onsite and offsite activities are addressed including traffic on access routes, and railroad construction and operation. A description of the predictive models, the analysis methodologies, the noise source inventories, the model outputs, and the evaluation criteria are included. 35 refs., 6 figs., 2 tabs.

  20. Deaf Smith County air quality analysis: Letter report: Revision 2

    SciTech Connect

    Not Available

    1985-11-01

    Air quality impacts due to site characterization, and repository construction and operation activities were evaluated in the Deaf Smith County Site, Texas environmental assessment (EA). The analyses on which the impact assessments are based made with dispersion models recommended by the EPA for such applications, meteorological data from a nearby representative National Weather Service station at Amarillo, Texas, and available background air quality data from an urban monitoring location. Maximum offsite concentrations of total suspended particulates, nitrogen dioxide, sulfur dioxide, and carbon monoxide were estimated for periods of maximum emissions identified for each pollutant. Estimates of total annual salt deposition resulting from repository salt handling operations were also made. 36 refs., 5 figs., 17 tabs.

  1. Smith-Magenis syndrome in Puerto Rico: a case report.

    PubMed

    Jardón, Javier; Izquierdo, Natalio J

    2009-01-01

    Smith-Magenis syndrome (SMS) is characterized by deletions in the short arm of chromosome 17. Systemic findings in patients with the syndrome include: dysmorphic facies and skeletal deformities. Ophthalmic findings in patients with the SMS include: strabismus, refractive errors, microcornea, iris anomalies, microphthalmos, and coloboma. A 14-year-old boy with cytogenetic studies confirming the SMS underwent a comprehensive ophthalmologic examination. The patient has a history of strabismus surgery. Clinical findings in this patient include: developmental delay, facial dysmorphism, enamel hypoplasia, short broad hands, clinodactyly, and scoliosis. Ocular findings in our patient include: myopia, iris nodules, loose zonules, and ectopia lentis. To our knowledge this is the first reported case of SMS in the Caribbean basin and the first case that report ectopia lentis in SMS. There is a possibility that lens subluxation in our patient is due to self inflicted trauma.

  2. Periventricular nodular heterotopia in Smith-Magenis syndrome.

    PubMed

    Capra, Valeria; Biancheri, Roberta; Morana, Giovanni; Striano, Pasquale; Novara, Francesca; Ferrero, Giovanni Battista; Boeri, Luca; Celle, Maria Elena; Mancardi, Maria Margherita; Zuffardi, Orsetta; Parrini, Elena; Guerrini, Renzo

    2014-12-01

    Smith-Magenis syndrome (SMS) is caused by an interstitial microdeletion of chromosome 17p11.2. A few patients with the typical SMS phenotype have RAI1 gene mutations. The syndrome is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioural and neurocognitive abnormalities, as well as variable multisystemic manifestations. Periventricular nodular heterotopia (PNH) is a genetically heterogeneous neuronal migration disorder characterized by subependymal heterotopic nodules, and is variably associated with other brain malformations, epileptic seizures and intellectual disability. Here we report on two patients harboring deletions of the 17p11.2 region in whom the SMS typical phenotype was associated with bilateral PNH. Our observations expand the spectrum of chromosomal rearrangements associated with PNH and indicate that abnormal neuronal migration may contribute to the neurocognitive phenotype of SMS.

  3. Smith college secondary math and science outreach program

    SciTech Connect

    Powell, J.A.; Clark, C.

    1994-12-31

    The Smith College Secondary Math and Science Outreach Program works collaboratively with front-line educators to encourage young women students of all abilities, especially underrepresented and underserved minorities, to continue studying math and science throughout high school. The program includes three main components: (1) Twenty-five to thirty teams of math/science teachers and guidance counselors participate in a year-long program which begins with a three-day Current Students/Future Scientists and Engineering Workshop. This event includes a keynote address, presentations and workshops by successful women in science and engineering, and hands-on laboratory sessions. Each participant receives a stipend and free room and board. Returning to their schools, the teacher-counselor teams implement ongoing plans designed to counteract gender bias in the sciences and to alert female students to the broad range of math, science, and engineering career choices open to them. A follow-up session in the spring allows the teams to present and discuss their year-long activities. (2) TRI-ON, a day of science for 120 ninth- and tenth- grade girls from schools with a large underserved and underrepresented population, is held in early spring. Girls discover the excitement of laboratory investigation and interact with female college science and math majors. (3) Teaching Internships, initiated in 1991, involve ten to fifteen Smith College math and science majors in teaching in public schools. The teaching interns experience the rewards and challenges of classroom teaching, and they also serve as role models for younger students.

  4. Smith-Purcell radiation in the highly relativistic regime

    SciTech Connect

    Walsh, J.E.; Woods, K.J.; Kirk, H.G.

    1995-12-31

    An electron moving over the surface of a diffraction grating will transfer a part of its kinetic energy to radiation via a velocity synchronous coupling with a slow space harmonic component of the field. Since the phase velocity of a slow space harmonic is less than the speed of light, the slow components decay exponentially, or evanesce, with distance above the grating and the evanescence scale is determined by the product of the relative velocity, {beta}, the relative energy, {gamma}, and the wavelength {lambda}. Thus, in the relativistic regime, good electron - grating coupling can be maintained at beam heights that are greater than the emitted wavelength. In order to explore this regime a series of experiments have been carried out with moderately energetic beams and an experiment with the 70-MeV beam at the Accelerator Test Facility is in the planning stage. The work has two basic goals: the first is to explore the characteristics of the spontaneous emission produced by the beam as it moves over the grating, and the second is to evaluate the potential of grating-coupled or Smith-Purcell free electron lasers. The spontaneous emission is of direct interest. It appears on the basis of work to date that the broad spectral distribution produced by a relativistic electron beam moving over a grating is potentially an alternative source for experiments of the type now carried out on synchrotron infrared beam lines. The grating, or a system of gratings, are also a potential alternative to the magnetic undulator and thus another basic approach to free electron laser design. The presentation will include a summary of the design of the experiment which is to be carried out on the 70-MeV A.T.F. beam line and a review of the theory of Smith-Purcell radiation in the high energy limit. Gain calculations and the role of beam quality in establishing performance limits will be discussed.

  5. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and Richard Kosiba...

  6. 76 FR 55413 - Proposed Safe Harbor Agreement for California Red-legged Frog, California Tiger Salamander, Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ... Tiger Salamander, Smith's Blue Butterfly, and Yadon's Piperia at Palo Corona Regional Park, Monterey... californiense) and federally endangered Smith's blue butterfly (Euphilotes enoptes smithi) under the Endangered..., California tiger salamander, Smith's blue butterfly, and Yadon's piperia on the property subject to...

  7. 75 FR 41922 - Notice of Intent To Rule on Request To Release Airport Property at Fort Smith Regional Airport...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Smith Regional Airport, Fort Smith, AR AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... comment on the release of land at Fort Smith Regional Airport under the provisions of Title 49, U.S.C... comments submitted to the FM must be mailed or delivered to Mr. John Parker, Airport Director, Fort...

  8. 75 FR 68401 - Duncan Smith and Gerald Altizer-Continuance in Control Exemption-Eighteen Thirty Group, LLC and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... Surface Transportation Board Duncan Smith and Gerald Altizer--Continuance in Control Exemption--Eighteen Thirty Group, LLC and Georges Creek Railway, LLC Duncan Smith and Gerald Altizer (collectively applicants... Georges Creek becoming Class III rail carriers. Mr. Smith owns 80% of Eighteen Thirty and 75% of...

  9. 75 FR 11919 - Smith and Nephew, Inc., Wound Management-Largo Division, Including On-Site Leased Workers From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Employment and Training Administration Smith and Nephew, Inc., Wound Management-Largo Division, Including On... workers of Smith and Nephew, Inc., Wound Management-Largo Division, Largo, Florida, including on-site... were employed on-site at the Largo, Florida location of Smith and Nephew, Inc., Wound...

  10. 76 FR 59115 - Notice of Availability of Patent Fee Changes Under the Leahy-Smith America Invents Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... Patent and Trademark Office Notice of Availability of Patent Fee Changes Under the Leahy- Smith America... days after the date of enactment of the Leahy-Smith America Invents Act (i.e., September 26, 2011) by... filed by electronic means in effect sixty days after the date of enactment of the Leahy-Smith...

  11. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... approximately 7.5 acres of airport property, located at the Michael J Smith Field, be used for aeronautical... Authority to release approximately 7.5 acres of airport property at the Michael J Smith Field. The...

  12. The eleventh reported case of Mulvihill-Smith syndrome in the literature

    PubMed Central

    2014-01-01

    Background The Mulvihill-Smith Syndrome was first recognized in 1975. After the recognition of the Mulvihill-Smith Syndrome, ten cases have been described. Case presentation This article describes the eleventh case of this syndrome in a male patient, 24 years-old with short stature and microcephaly with mild cognitive impairment, deafness and allergic conjunctivitis. The patient was hospitalized several times for repeated infections, and the presence of multiple melanocytic nevi on his skin was noticed. Conclusions Based on the entire set of signs and symptoms presented in our study, it was diagnosed the patient with Mulvihill-Smith Syndrome. PMID:24397283

  13. Ambengana Millidge & Russell-Smith, 1992, a synonym of Neriene Blackwall, 1833 (Araneae, Linyphiidae)

    PubMed Central

    Xu, Xin; Jie, Liu; Chen, Jian

    2010-01-01

    Abstract The taxonomic status of the genus Ambengana Millidge & Russell-Smith, 1992, is revised on the basis of its original description, illustrations and re-examination of the type species. A new synonymy is proposed: Ambengana complexipalpis Millidge & Russell-Smith, 1992 (the type species of Ambengana) syn. n. with Neriene birmanica (Thorell, 1887). Therefore,the genus Ambengana Millidge & Russell-Smith, 1992 syn. n. is synonymized with Neriene Blackwall, 1833. A morphological re-description, diagnosis and comparative illustrations are provided for Neriene birmanica as well. PMID:21594123

  14. Autism spectrum features in Smith-Magenis syndrome.

    PubMed

    Laje, Gonzalo; Morse, Rebecca; Richter, William; Ball, Jonathan; Pao, Maryland; Smith, Ann C M

    2010-11-15

    Smith-Magenis syndrome (SMS; OMIM 182290) is a neurodevelopmental disorder characterized by a well-defined pattern of anomalies. The majority of cases are due to a common deletion in chromosome 17p11.2 that includes the RAI1 gene. In children with SMS, autistic-like behaviors and symptoms start to emerge around 18 months of age. This study included 26 individuals (15 females and 11 males), with a confirmed deletion (del 17p11.2). Parents/caregivers were asked to complete the Social Responsiveness Scale (SRS) and the Social Communication Questionnaire (SCQ) both current and lifetime versions. The results suggest that 90% of the sample had SRS scores consistent with autism spectrum disorders. Moreover, females showed more impairment in total T-scores (P = 0.02), in the social cognition (P = 0.01) and autistic mannerisms (P = 0.002) subscales. The SCQ scores are consistent to show that a majority of individuals may meet criteria for autism spectrum disorders at some point in their lifetime. These results suggest that SMS needs to be considered in the differential diagnosis of autism spectrum disorders but also that therapeutic interventions for autism are likely to benefit individuals with SMS. The mechanisms by which the deletion of RAI1 and contiguous genes cause psychopathology remain unknown but they provide a solid starting point for further studies of gene-brain-behavior interactions in SMS and autism spectrum disorders.

  15. The Galactic fountain as an origin for the Smith Cloud

    NASA Astrophysics Data System (ADS)

    Marasco, A.; Fraternali, F.

    2017-01-01

    The recent discovery of an enriched metallicity for the Smith high-velocity H I Cloud (SC) lends support to a Galactic origin for this system. We use a dynamical model of the galactic fountain to reproduce the observed properties of the SC. In our model, fountain clouds are ejected from the region of the disc spiral arms and move through the halo interacting with a pre-existing hot corona. We find that a simple model where cold gas outflows vertically from the Perseus spiral arm reproduces the kinematics and the distance of the SC, but is in disagreement with the cloud's cometary morphology, if this is produced by ram-pressure stripping by the ambient gas. To explain the cloud morphology, we explore two scenarios: (i) the outflow is inclined with respect to the vertical direction and (ii) the cloud is entrained by a fast wind that escapes an underlying superbubble. Solutions in agreement with all observational constraints can be found for both cases, the former requires outflow angles >40° while the latter requires ≳1000 km s-1 winds. All scenarios predict that the SC is in the ascending phase of its trajectory and has large - but not implausible - energy requirements.

  16. Pharmacological treatment of disruptive behavior in Smith-Magenis syndrome.

    PubMed

    Laje, Gonzalo; Bernert, Rebecca; Morse, Rebecca; Pao, Maryland; Smith, Ann C M

    2010-11-15

    Smith-Magenis syndrome (SMS) is a complex genetic syndrome caused by an interstitial deletion of chromosome 17p11.2. Children and adults with SMS appear to have unique neurobehavioral problems that include: sleep disturbance, self-injurious and maladaptive behaviors, stereotypies, and sensory integration disorders. We gathered retrospective psychotropic use information from parents or other caregivers of 62 individuals with SMS who were asked about use of psychotropic medication from a list of commonly used psychiatric medications. For those drugs identified, respondents were asked to rate the experience with the particular medication using a likert-type scale. Drugs were grouped into seven main categories: (1) stimulants; (2) antidepressants; (3) antipsychotics; (4) sleep aides; (5) mood stabilizers; (6) alpha 2 agonists; and (7) benzodiazepines. Relative frequencies, means and standard deviations pertaining to age and medication effect were derived for each medication category. Six of the seven medication categories examined showed no meaningful deviations from the "no change" score. The benzodiazepine group showed a mild detrimental effect. There were no gender differences in efficacy. Use of psychotropic medication started early in life (mean age 5 years), particularly with sleep aides. Although no medication category was identified as efficacious in SMS, all the categories reported herein may be considered as an option for brief symptomatic relief.

  17. Smith River Rancheria's Development of an Energy Organization Investigation

    SciTech Connect

    W.G Buehler & Associates

    2007-08-27

    Smith River Rancheria (SRR), for some time, has had a strong commitment to attaining energy selfsufficiency, to reduce overall energy costs and concurrently initiate economic development within the community. Early on it was recognized that the development of an energy organization was important and for this reason was made part of the SRR's strategic review not only for economic development but also the reduction of energy costs. Towards this end, SRR retained Werner G. Buehler of W.G. Buehler & Associates to investigate the many phases or steps required to establish such an energy organization and determine, if in fact, it could benefit the Tribe. The basic phases are delineated as: (1) Identify potential sources of wholesale power and transmission paths; (2) Evaluating the various forms of energy organizations; (3) Determining the benefits (and disadvantages) of each form of organization; (4) Gathering costs to organize and operate the selected form or energy organization; (5) Performing an economic analysis of forming and operating an energy organization; and (6) Develop an implementation plan.

  18. Peroxisomal cholesterol biosynthesis and Smith-Lemli-Opitz syndrome

    SciTech Connect

    Weinhofer, Isabelle; Kunze, Markus; Stangl, Herbert; Porter, Forbes D.; Berger, Johannes . E-mail: johannes.berger@meduniwien.ac.at

    2006-06-23

    Smith-Lemli-Opitz syndrome (SLOS), caused by 7-dehydrocholesterol-reductase (DHCR7) deficiency, shows variable severity independent of DHCR7 genotype. To test whether peroxisomes are involved in alternative cholesterol synthesis, we used [1-{sup 14}C]C24:0 for peroxisomal {beta}-oxidation to generate [1-{sup 14}C]acetyl-CoA as cholesterol precursor inside peroxisomes. The HMG-CoA reductase inhibitor lovastatin suppressed cholesterol synthesis from [2-{sup 14}C]acetate and [1-{sup 14}C]C8:0 but not from [1-{sup 14}C]C24:0, implicating a peroxisomal, lovastatin-resistant HMG-CoA reductase. In SLOS fibroblasts lacking DHCR7 activity, no cholesterol was formed from [1-{sup 14}C]C24:0-derived [1-{sup 14}C]acetyl-CoA, indicating that the alternative peroxisomal pathway also requires this enzyme. Our results implicate peroxisomes in cholesterol biosynthesis but provide no link to phenotypic variation in SLOS.

  19. Craniofacial and dental phenotype of Smith-Magenis syndrome.

    PubMed

    Tomona, Natalia; Smith, Ann C M; Guadagnini, Jean Pierre; Hart, Thomas C

    2006-12-01

    The aim of this study was to assess and characterize dental and craniofacial findings in individuals with a confirmed diagnosis of Smith-Magenis syndrome (SMS). Extraoral and intraoral examination including dental and craniofacial radiographs and three-dimensional facial photoimaging were performed for 15 cases between ages 4 and 19 years old. Tooth agenesis (13/15 cases) affecting primarily the mandibular second premolars and taurodontism (13/15 cases) were common findings. Dilaceration of the tooth roots was present in one-third of the cases. At least one dental anomaly was present in each case. These findings occur with greater frequency than in the general population (P < 0.001). An age-related increase in decayed and restored teeth was found. Poorer oral hygiene, increased dental plaque, and increased gingival inflammation progressed from childhood to teenage years. Radiographic findings suggest the prognathic appearance is not caused by excessive mandibular growth. Other findings including protrusion of the mandibular anterior teeth, increased bony chin size, and macroglossia were noted, which may contribute to the prognathic appearance. The high prevalence of dental anomalies (>90%) further expands the phenotype and indicates that dental evaluation may aid in the diagnosis of SMS.

  20. Nesting behavior of Podium denticulatum Smith (Hymenoptera: Sphecidae).

    PubMed

    Ribeiro, Favi; Garófalo, Carlos A

    2010-01-01

    The nesting behavior of Podium denticulatum Smith was studied on the campus of Ribeirão Preto of the Universidade de São Paulo, SP, Brazil, from September 2003 to August 2005. The wasps established their nests in bamboo canes ranging from 11.4 cm to 26.2 cm in length and from 0.7 cm to 1.8 cm in internal diameter. Podium denticulatum nested almost exclusively in the hot and wet season (September-April), producing at least five generations per year. The cell provisioning was made with adult and nymphal cockroaches (Blattellidae) which were arranged venter-up and with the head inward toward the inner end of the cell. The construction of a temporary closure occurred in cells that took more than one day to be provisioned. The cells provisioned with a greater number of prey were more likely to produce females than males. The nests included 1-6 brood cells separated by mud partitions and arranged in a linear series. The innermost cells of the nests produced females, and the outermost cells produced males. Nests were parasitized by Eulophidae (Melittobia sp.), Chrysididae and Tachinidae.

  1. STS-103 M.S. Steven Smith during TCDT activities

    NASA Technical Reports Server (NTRS)

    1999-01-01

    STS-103 Mission Specialist Steven L. Smith gets ready to practice driving a small armored personnel carrier that is part of emergency egress training during Terminal Countdown Demonstration Test (TCDT) activities. The tracked vehicle could be used by the crew in the event of an emergency at the pad during which the crew must make a quick exit from the area. The TCDT also provides simulated countdown exercises and opportunities to inspect the mission payloads in the orbiter's payload bay. STS-103 is a 'call-up' mission due to the need to replace and repair portions of the Hubble Space Telescope. Although Hubble is operating normally and conducting its scientific observations, only three of its six gyroscopes are working properly. Four EVA's are planned to make the necessary repairs and replacements on the telescope. The other STS-103 crew members are Commander Curtis L. Brown Jr., Pilot Scott J. Kelly, and Mission Specialists John M. Grunsfeld (Ph.D.), C. Michael Foale (Ph.D.), (Ph.D.), and Claude Nicollier of Switzerland and Jean-Frangois Clervoy of France, who are with the European Space Agency. The mission is targeted for launch Dec. 6 at 2:37 a.m. EST.

  2. Basic repository environmental assessment design basis: Deaf Smith County site

    SciTech Connect

    Not Available

    1988-03-01

    This study examines the engineering factors and costs associated with the construction, operation, and decommissioning of a high-level nuclear waste repository in salt in the Palo Duro Basin in Deaf Smith County, Texas. The study assumes a repository capacity of 36,000 metric tons of heavy metal (MTHM) of unreprocessed spent fuel and 36,000 MTHM of commercial high-level reprocessing waste, along with 7,020 canisters of defense high-level reprocessing waste and associated quantities or remote- and contact-handled transuranic waste (TRU). With the exception of TRU, all the waste forms are placed in 300- to 1000-year-life carbon-steel waste packages in a collocated waste handling and packaging facility (WHPF), which is also described. The construction, operation, and decommissioning of the proposed repository is estimated to cost approximately $4.64 billion. Costs include those for the collocate WHPF, engineering, and contingency, but exclude waste form assembly and shipment to the site and waste package fabrication and shipment to the site. These costs reflect the relative average wage rates of the region, the relatively easy access to the site, and the relatively weak nature of the salt at this site. Construction would require an estimated 7 to 7.5 years. Engineering factors and costs are not strongly influenced by environmental considerations. 62 refs., 24 figs., 20 tabs.

  3. A functional network module for Smith-Magenis syndrome.

    PubMed

    Girirajan, S; Truong, H T; Blanchard, C L; Elsea, S H

    2009-04-01

    Disorders with overlapping diagnostic features are grouped into a network module. Based on phenotypic similarities or differential diagnoses, it is possible to identify functional pathways leading to individual features. We generated a Smith-Magenis syndrome (SMS)-specific network module utilizing patient clinical data, text mining from the Online Mendelian Inheritance in Man database, and in vitro functional analysis. We tested our module by functional studies based on a hypothesis that RAI1 acts through phenotype-specific pathways involving several downstream genes, which are altered due to RAI1 haploinsufficiency. A preliminary genome-wide gene expression study was performed using microarrays on RAI1 haploinsufficient cells created by RNAi-based approximately 50% knockdown of RAI1 in HEK293T cells. The top dysregulated genes were involved in growth signaling and insulin sensitivity, neuronal differentiation, lipid biosynthesis and fat mobilization, circadian activity, behavior, renal, cardiovascular and skeletal development, gene expression, and cell-cycle regulation and recombination, reflecting the spectrum of clinical features observed in SMS. Validation using real-time quantitative reverse transcriptase polymerase chain reaction confirmed the gene expression profile of 75% of the selected genes analyzed in both HEK293T RAI1 knockdown cells and SMS lymphoblastoid cell lines. Overall, these data support a method for identifying genes and pathways responsible for individual clinical features in a complex disorder such as SMS.

  4. Smith-Magenis syndrome: clinical evaluation in seven Brazilian patients.

    PubMed

    Gamba, B F; Vieira, G H; Souza, D H; Monteiro, F F; Lorenzini, J J; Carvalho, D R; Morreti-Ferreira, D

    2011-10-31

    Smith-Magenis syndrome (SMS) is a complex congenital anomaly characterized by craniofacial anomalies, neurological and behavioral disorders. SMS is caused by a deletion in region 17p11.2, which includes the RAI1 gene (90% of cases), or by point mutation in the RAI1 gene (10% of cases). Laboratory diagnosis is through cytogenetic analysis by GTG banding and molecular cytogenetic analysis by FISH. We carried out an active search for patients in Associations of Parents and Friends of Exceptional Children (APAE) of São Paulo and genetic centers in Brazil. Forty-eight patients were screened for mental retardation, craniofacial abnormalities and stereotyped behavior with a diagnosis of SMS. In seven of them, chromosome banding at high resolution demonstrated chromosome 17p11.2 deletions, confirmed by FISH. We also made a meta-analysis of 165 cases reported between 1982 and 2010 to compare with the clinical data of our sample. We demonstrated differences between the frequencies of clinical signs among the cases reported and seven Brazilian cases of this study, such as dental anomalies, strabismus, ear infections, deep hoarse voice, hearing loss, and cardiac defects. Although the gold standard for diagnosis of SMS is FISH, we found that the GTG banding technique developed to evaluate chromosome 17 can be used for the SMS diagnosis in areas where the FISH technique is not available.

  5. Historic American Buildings Survey, D.H. Smith, Photographer, 1923 VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Historic American Buildings Survey, D.H. Smith, Photographer, 1923 VIEW OF FRONT AND SIDE. - Merion Friends Meeting House, 615 Montgomery Avenue (changed from Montgomery Avenue & Meetinghouse Lane), Narberth, Montgomery County, PA

  6. An Extension of the Smith Cloud Stream Toward the Galactic Plane

    NASA Astrophysics Data System (ADS)

    Kornacki, Evan; Lockman, F. J.

    2010-01-01

    We have been using the Green Bank Telescope (GBT) at the NRAO to map 21cm HI emissions in a large area around the high-velocity cloud known as the Smith Cloud. Earlier work with the GBT established that the Smith Cloud has a trajectory that puts it on a collision course with the disk of the Milky Way in about 30 Myr at a distance of about 11 kpc from the Galactic Center. However, the earlier data covered only the main piece of the Cloud, and suggested more HI associated with this object might be found over a larger area. The new data cover more than 200 square degrees. We have found evidence for a component of the Smith Cloud that lies further along its trajectory and is crossing the Galactic plane. Detailed information on this new component, its properties, and the implications for the origin and fate of the Smith Cloud will be presented.

  7. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Types 8 and 11, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  8. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Four-Bedroom, Single-Family Type 10, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  9. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Three-Bedroom Duplex Type 4, Acacia Road, Birch Circle, Cedar Drive and Elm Drive, Pearl City, Honolulu County, HI

  10. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  11. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 9, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  12. Camp H.M. Smith and Navy Public Works Center Manana Title ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  13. George E. KidderSmith, photographer, April 1945, Photograph #1101. VIEW OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    George E. Kidder-Smith, photographer, April 1945, Photograph #110-1. VIEW OF BUILDING 23, SOUTH SIDE WITH ARCADE, FACING NORTHWEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

  14. George E. KidderSmith, April 1945, Photograph #1338. VIEW OF BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    George E. Kidder-Smith, April 1945, Photograph #133-8. VIEW OF BUILDING 23, FRONT SIDE FROM ACROSS COURTYARD, FACING WEST - Roosevelt Base, Auditorium-Gymnasium, West Virginia Street between Richardson & Reeves Avenues, Long Beach, Los Angeles County, CA

  15. Smith's Sentiments (1759) and Wright's Passions (1601): the beginnings of sociology.

    PubMed

    Barbalet, Jack

    2005-06-01

    Treatments of sources of Adam Smith's sociological theory of the self and associated ideas in The Theory of Moral Sentiments typically refer to classical antecedents or the work of his teacher Francis Hutcheson or his contemporary David Hume. During the seventeenth century, however, many books on the passions were published in London that arguably constitute an important but neglected source of Smith's treatment of moral sentiments. These works are largely forgotten today but at the time were widely read. They are not philosophical, partly devotional and predominantly psychological. Although Smith does not refer to these works his argument resembles theirs in many places. The importance of the seventeenth-century books on the passions, apart from their role in the history of psychology, is their bearing on contemporary economic practices. In this paper the connections between Smith and one of these books, Thomas Wright's The Passions of the Minde in Generall, are indicated.

  16. 77 FR 51064 - Huntington Foam LLC, Fort Smith, AR; Notice of Affirmative Determination Regarding Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Huntington Foam LLC, Fort Smith, AR; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated May 21, 2012, the State...

  17. An optimal control approach to pilot/vehicle analysis and Neal-Smith criteria

    NASA Technical Reports Server (NTRS)

    Bacon, B. J.; Schmidt, D. K.

    1984-01-01

    The approach of Neal and Smith was merged with the advances in pilot modeling by means of optimal control techniques. While confirming the findings of Neal and Smith, a methodology that explicitly includes the pilot's objective in attitude tracking was developed. More importantly, the method yields the required system bandwidth along with a better pilot model directly applicable to closed-loop analysis of systems in any order.

  18. Measuring short electron bunch lengths using coherent smith-purcell radiation

    DOEpatents

    Nguyen, Dinh C.

    1999-01-01

    A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches.

  19. Measuring short electron bunch lengths using coherent Smith-Purcell radiation

    DOEpatents

    Nguyen, D.C.

    1999-03-30

    A method is provided for directly determining the length of sub-picosecond electron bunches. A metallic grating is formed with a groove spacing greater than a length expected for the electron bunches. The electron bunches are passed over the metallic grating to generate coherent and incoherent Smith-Purcell radiation. The angular distribution of the coherent Smith-Purcell radiation is then mapped to directly deduce the length of the electron bunches. 8 figs.

  20. User experience network. Erroneous downstream occlusion alarms may disable Smiths Medical CADD-Solis infusion pumps.

    PubMed

    2010-10-01

    Due to an issue in manufacturing, downstream occlusion (DSO) sensors in some Smiths Medical CADD-Solis infusion pumps may drift out of calibration, potentially resulting in erroneous alarms that disable the units. Hospitals experiencing the problem should return affected units to Smiths Medical for recalibration (free of charge) and should consider testing all their CADD-Solis pumps during routine maintenance to ensure that they alarm appropriately for downstream occlusions.

  1. [Sleep disturbances in Smith-Magenis syndrome: treatment with melatonin and beta-adrenergic antagonists].

    PubMed

    Van Thillo, A; Devriendt, K; Willekens, D

    2010-01-01

    Smith-Magenis syndrome is a generic disorder, characterised by physical, neurological and behavioural features and caused by a 17p11.2 deletion. Patients with this syndrome typically display an inversion of the sleep-wake cycle. In this article we describe clinical developments in a two-year-old girl with Smith-Magenis syndrome whose sleep problems were successfully treated with melatonin and beta-adrenergic blockers. We also mention relevant data obtained in our literature search.

  2. American and British Mental Health Workers Look at Rehabilitation

    ERIC Educational Resources Information Center

    Askenasy, Alexander R.

    1969-01-01

    Study supported by funds from the Vocational Rehabilitation Administration, the Research Institute for the Study of Man, the Postgraduate Center for Mental Health, and Smith Kline & French Laboratories.

  3. Smith's Cloud: No chemistry but we did find some of the Milky Way's Missing Baryons

    NASA Astrophysics Data System (ADS)

    Minter, Anthony Howard

    2017-01-01

    The Green Bank Observatory's 100 meter Green Bank Telescope (GBT) was used to search for OH emission from Smith's Cloud. Smith's Cloud is a large, few 106 Solar Mass cloud which will impact the Milkay Way's disk in about 35 Million years. The origin of Smith's Cloud is uncertain but its environmental conditions should have allowed for the formation of molecules. The GBT OH observations did not detect any OH from Smith's Cloud and limits the metalicity to be below 3% solar. Sulpher has been observed in the Smith's Cloud with a metalicity of 0.5 solar. Since OH is the first molecule to form and should have been easily detected, the GBT observations indicate that there is currently no active chemistry occuring in Smith's Cloud.The observations did turn up a substantial amount of OH emission from the Milky Way along the line of sight. The observed lines of sight do not have any detected CO emission and suggests "dark gas" (dense enough to form OH but not CO) is present. The column density of this "dark gas" could be as high as 1018-19 at a galactic latitude of 35o. The "dark gas" could represent a significant fraction of the Milky Way's missing baryons.

  4. Neurologic and developmental features of the Smith-Magenis syndrome (del 17p11.2).

    PubMed

    Gropman, Andrea L; Duncan, Wallace C; Smith, Ann C M

    2006-05-01

    The Smith-Magenis syndrome is a rare, complex multisystemic disorder featuring, mental retardation and multiple congenital anomalies caused by a heterozygous interstitial deletion of chromosome 17p11.2. The phenotype of Smith-Magenis syndrome is characterized by a distinct pattern of features including infantile hypotonia, generalized complacency and lethargy in infancy, minor skeletal (brachycephaly, brachydactyly) and craniofacial features, ocular abnormalities, middle ear and laryngeal abnormalities including hoarse voice, as well as marked early expressive speech and language delays, psychomotor and growth retardation, and a 24-hour sleep disturbance. A striking neurobehavioral pattern of stereotypies, hyperactivity, polyembolokoilamania, onychotillomania, maladaptive and self-injurious and aggressive behavior is observed with increasing age. The diagnosis of Smith-Magenis syndrome is based upon the clinical recognition of a constellation of physical, developmental, and behavioral features in combination with a sleep disorder characterized by inverted circadian rhythm of melatonin secretion. Many of the features of Smith-Magenis syndrome are subtle in infancy and early childhood, and become more recognizable with advancing age. Infants are described as looking "cherubic" with a Down syndrome-like appearance, whereas with age the facial appearance is that of relative prognathism. Early diagnosis requires awareness of the often subtle clinical and neurobehavioral phenotype of the infant period. Speech delay with or without hearing loss is common. Most children are diagnosed in mid-childhood when the features of the disorder are most recognizable and striking. While improvements in cytogenetic analysis help to bring cases to clinical recognition at an earlier age, this review seeks to increase clinical awareness about Smith-Magenis syndrome by presenting the salient features observed at different ages including descriptions of the neurologic and behavioral

  5. Draft environmental assessment: Deaf Smith County site, Texas. Nuclear Waste Policy Act (Section 112). [Contains Glossary

    SciTech Connect

    Not Available

    1984-12-01

    In February 1983, the US Department of Energy identified a location in Deaf Smith County, Texas, as one of nine potentially acceptable sites for a mined geologic repository for spent nuclear fuel and high-level radioactive waste. The potentially acceptable site was subsequently narrowed to an area of 9 square miles. To determine their suitability, the Deaf Smith site and the eight other potentially acceptable sites have been evaluated in accordance with the DOE's General Guidelines for the Recommendation of Sites for Nuclear Waste Repositories. These evaluations are reported in this draft environmental assessment, which is being issued for public review and comment. The DOE findings and determinations that are based on these evaluations are preliminary and subject to public review and comment. A final EA will be prepared after considering the comments received. On the basis of the evaluations reported in this draft EA, the DOE has found that the Deaf Smith site is not disqualified under the guidelines. The site is in the Permian Basin, which is one of five distinct geohydrologic settings considered for the first repository. This setting contains one other potentially acceptable site - the Swisher site. Although the Swisher site appears to be suitable for site characterization, DOE has concluded that the Deaf Smith site is the preferred site. The DOE finds that the site is suitable for site characterization because the evidence does not support a conclusion that the site will not be able to meet each of the qualifying conditions specified in the guidelines. On the basis of these findings, the DOE is proposing to nominate the Deaf Smith site as one of five sites suitable for characterization. Having compared the Deaf Smith site with the other four sites proposed for nomination, the DOE has determined that the Deaf Smith site is one of the three preferred sites for recommendation to the President as candidates for characterization.

  6. Adrenal function in Smith-Lemli-Opitz Syndrome

    PubMed Central

    Bianconi, Simona E; Conley, Sandra K; Keil, Meg F; Sinaii, Ninet; Rother, Kristina I; Porter, Forbes D; Stratakis, Constantine A

    2012-01-01

    Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation syndrome due to mutations of the 7-dehydrocholesterol reductase gene (DHCR7), which leads to a deficiency of cholesterol synthesis and an accumulation of 7-dehydrocholesterol and related metabolites. The SLOS clinical spectrum ranges from multiple major malformations to a mild phenotype with dysmorphic features, intellectual disability and a specific behavioral presentation. Several cases of SLOS with adrenal insufficiency have been described. We performed ovine corticotropin (oCRH) testing in 35 SLOS patients and 16 age- and gender-matched controls. We reviewed prior ACTH stimulation tests of our SLOS patients (19 of 35 available) and reviewed ACTH stimulation tests from additional 10 other SLOS patients. Results from oCRH testing showed that patients with SLOS had significantly higher ACTH baseline values than healthy controls (24.8 ± 15.3 pg/mL vs. 17.8 ± 7.5 pg/mL, p=0.034). However, no statistically significant differences were noted for peak ACTH values (74.4 ± 35.0 pg/mL vs. 64.0 ± 24.9 pg/mL, p=0.303) and for baseline (14.2 ± 7.8 mcg/dL vs. 14.2 ± 6.3 mcg/dL, p=0.992) and peak cortisol values (28.2 ± 7.9 mcg/dL vs. 24.8 ± 8.1 mcg/dL, p=0.156). The area-under-the-curve (AUC) was not significantly different in SLOS patients compared to controls for both ACTH (250.1 ± 118.7 pg/mL vs. 195.3 ± 96.6 pg/mL, p=0.121) as well as cortisol secretion (83.1 ± 26.1 mcg/dL vs. 77.8 ± 25.9 mcg/dL, p=0.499). ACTH stimulation test was normal in 28 of 29 tests. The individual with the abnormal ACTH stimulation test had a normal oCRH test during the same evaluation. The slightly increased baseline ACTH level seen during oCRH testing may be due to compensated mild adrenocortical insufficiency. However, we were able to show that our cohort affected with SLOS had an adequate stress response and that in mild to moderate cases of SLOS stress steroid coverage should not be required. PMID:21990131

  7. Searching for Dark Matter Annihilation in the Smith High-Velocity Cloud

    NASA Technical Reports Server (NTRS)

    Drlica-Wagner, Alex; Gomez-Vargas, German A.; Hewitt, John W.; Linden, Tim; Tibaldo, Luigi

    2014-01-01

    Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use gamma-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant gamma-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section (approximately 3 x 10 (sup -26) cubic centimeters per second) for dark matter masses less than or approximately 30 gigaelectronvolts annihilating via the B/B- bar oscillation or tau/antitau channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

  8. VLA Observations of the Magnetic Field of the Smith High Velocity Cloud

    NASA Astrophysics Data System (ADS)

    Betti, Sarah; Hill, Alex S.; Mao, Sui Ann; McClure-Griffiths, Naomi M.; Lockman, Felix J.; Benjamin, Robert A.; Gaensler, Bryan M.

    2017-01-01

    High velocity clouds (HVCs) are hydrogen gas clouds around galaxies with velocities inconsistent with Galactic rotation. HVCs may fuel future star formation and drive galaxy evolution. The Smith Cloud is an HVC with an orbit suggesting it has made at least one passage through the disk. A measured magnetic field suggests how it survived passage through the Galactic halo. The Faraday rotation measure (RM) provides information about the strength and direction of the magnetic field. We use the Karl G. Jansky Very Large Array (VLA) to obtain reliable RMs towards ~950 background point sources to measure the geometry of the magnetic field of the Smith Cloud. These RMs constrain the strength of the magnetic field at the head, tail, and body of the Smith Cloud while RMs directly behind the Smith Cloud suggest there is ionized gas associated with the cloud that has not previously been detected. The confirmation of the magnetic field of the Smith Cloud along with a detailed morphology of the magnetic field structure will constrain how HVCs pass through the Galactic halo without losing their gas and survive the passage through the intergalactic and interstellar media.

  9. Searching for dark matter annihilation in the Smith high-velocity cloud

    SciTech Connect

    Drlica-Wagner, Alex; Gómez-Vargas, Germán A.; Hewitt, John W.; Linden, Tim; Tibaldo, Luigi

    2014-07-20

    Recent observations suggest that some high-velocity clouds may be confined by massive dark matter halos. In particular, the proximity and proposed dark matter content of the Smith Cloud make it a tempting target for the indirect detection of dark matter annihilation. We argue that the Smith Cloud may be a better target than some Milky Way dwarf spheroidal satellite galaxies and use γ-ray observations from the Fermi Large Area Telescope to search for a dark matter annihilation signal. No significant γ-ray excess is found coincident with the Smith Cloud, and we set strong limits on the dark matter annihilation cross section assuming a spatially extended dark matter profile consistent with dynamical modeling of the Smith Cloud. Notably, these limits exclude the canonical thermal relic cross section (∼ 3 × 10{sup –26} cm{sup 3} s{sup –1}) for dark matter masses ≲ 30 GeV annihilating via the b b-bar or τ{sup +}τ{sup –} channels for certain assumptions of the dark matter density profile; however, uncertainties in the dark matter content of the Smith Cloud may significantly weaken these constraints.

  10. Conical diffraction effect in optical and x-ray Smith-Purcell radiation

    NASA Astrophysics Data System (ADS)

    Sergeeva, D. Yu.; Tishchenko, A. A.; Strikhanov, M. N.

    2015-05-01

    Smith-Purcell radiation is a well-known phenomenon, which provides a noninvasive scheme for diagnostics of charged particle beams and is used as an effective source of electromagnetic waves, e.g., in the orotron, the free electron laser, etc. In this paper we develop the theory of Smith-Purcell radiation (SPR) for the little-investigated case of arbitrary angles between the charged particle trajectories and the rulings of a grating. The effect of conical diffraction arising here changes drastically the space distribution of the radiation. By contrast to the only existing approach, described by Haeberle et al. [Phys. Rev. E 55, 4675 (1997)], which requires difficult numerical calculations, we give a fully analytic theory of SPR. Also, in this paper we present for the first time the theory of x-ray Smith-Purcell radiation. Evanescent waves on the surface are shown to lead to strong enhancement of Smith-Purcell radiation, through a resonant mechanism. The results are important for the description of real divergent high-brightness beams and for the development of novel noninvasive diagnostic schemes based on the Smith-Purcell effect.

  11. Groundwater and surface-water interaction within the upper Smith River Watershed, Montana 2006-2010

    USGS Publications Warehouse

    Caldwell, Rodney R.; Eddy-Miller, Cheryl A.

    2013-01-01

    The 125-mile long Smith River, a tributary of the Missouri River, is highly valued as an agricultural resource and for its many recreational uses. During a drought starting in about 1999, streamflow was insufficient to meet all of the irrigation demands, much less maintain streamflow needed for boating and viable fish habitat. In 2006, the U.S. Geological Survey, in cooperation with the Meagher County Conservation District, initiated a multi-year hydrologic investigation of the Smith River watershed. This investigation was designed to increase understanding of the water resources of the upper Smith River watershed and develop a detailed description of groundwater and surface-water interactions. A combination of methods, including miscellaneous and continuous groundwater-level, stream-stage, water-temperature, and streamflow monitoring was used to assess the hydrologic system and the spatial and temporal variability of groundwater and surface-water interactions. Collectively, data are in agreement and show: (1) the hydraulic connectedness of groundwater and surface water, (2) the presence of both losing and gaining stream reaches, (3) dynamic changes in direction and magnitude of water flow between the stream and groundwater with time, (4) the effects of local flood irrigation on groundwater levels and gradients in the watershed, and (5) evidence and timing of irrigation return flows to area streams. Groundwater flow within the alluvium and older (Tertiary) basin-fill sediments generally followed land-surface topography from the uplands to the axis of alluvial valleys of the Smith River and its tributaries. Groundwater levels were typically highest in the monitoring wells located within and adjacent to streams in late spring or early summer, likely affected by recharge from snowmelt and local precipitation, leakage from losing streams and canals, and recharge from local flood irrigation. The effects of flood irrigation resulted in increased hydraulic gradients

  12. Geology, paleoclimatology and the evolution of the kidney: some explorations into the legacy of Homer Smith.

    PubMed

    Kooman, Jeroen P

    2012-01-01

    The aim of this review is to perform an overview of the relation between kidney development in different species and new developments in plate tectonics and paleoclimatology, which likely had a remarkable effect on evolution. The review follows the ideas of Homer Smith, but adds new data on the subjects which were unknown in Homer Smith's time. The structure and function of the kidney are a result of hundreds of millions of years of evolution, in which adaptations had to be made in response to environmental demands while maintaining the kidney's integrated function. The ideas of Homer Smith have greatly contributed to our understanding of this process, and continue to be of relevance both for researchers as well as physicians working in the field of kidney disease.

  13. Improving the Mapping of Smith-Waterman Sequence Database Searches onto CUDA-Enabled GPUs

    PubMed Central

    Huang, Liang-Tsung; Wu, Chao-Chin; Lai, Lien-Fu; Li, Yun-Ju

    2015-01-01

    Sequence alignment lies at heart of the bioinformatics. The Smith-Waterman algorithm is one of the key sequence search algorithms and has gained popularity due to improved implementations and rapidly increasing compute power. Recently, the Smith-Waterman algorithm has been successfully mapped onto the emerging general-purpose graphics processing units (GPUs). In this paper, we focused on how to improve the mapping, especially for short query sequences, by better usage of shared memory. We performed and evaluated the proposed method on two different platforms (Tesla C1060 and Tesla K20) and compared it with two classic methods in CUDASW++. Further, the performance on different numbers of threads and blocks has been analyzed. The results showed that the proposed method significantly improves Smith-Waterman algorithm on CUDA-enabled GPUs in proper allocation of block and thread numbers. PMID:26339591

  14. A modern approach to pilot/vehicle analysis and the Neal-Smith criteria

    NASA Technical Reports Server (NTRS)

    Bacon, B. J.; Schmidt, D. K.

    1982-01-01

    The present investigation is concerned with the development of a better pilot modelling technique via optimal control theory, taking into account concepts concerning 'pilot rating' considered by Neal and Smith (1970). The investigation conducted by Neal and Smith had the objective to provide data on the effects of Flight Control System dynamics and to develop a design criterion capable of pinpointing pilot problem areas encountered in performing a given task. Neal and Smith devised a 'pilot-in-the-loop' analysis capable of showing problem areas in pitch attitude tracking. Unfortunately the employed method has some drawbacks. The current investigation attempts, therefore, to provide an alternate approach which makes use of an optimal-control pilot model. An optimal control model (OCM) had been discussed by Kleinman et al. (1970). It is shown that the alternate approach, based on the OCM, offers some distinct advantages.

  15. Smith predictor based-sliding mode controller for integrating processes with elevated deadtime.

    PubMed

    Camacho, Oscar; De la Cruz, Francisco

    2004-04-01

    An approach to control integrating processes with elevated deadtime using a Smith predictor sliding mode controller is presented. A PID sliding surface and an integrating first-order plus deadtime model have been used to synthesize the controller. Since the performance of existing controllers with a Smith predictor decrease in the presence of modeling errors, this paper presents a simple approach to combining the Smith predictor with the sliding mode concept, which is a proven, simple, and robust procedure. The proposed scheme has a set of tuning equations as a function of the characteristic parameters of the model. For implementation of our proposed approach, computer based industrial controllers that execute PID algorithms can be used. The performance and robustness of the proposed controller are compared with the Matausek-Micić scheme for linear systems using simulations.

  16. Breeding habitat associations and predicted distribution of an obligate tundra-breeding bird, Smith's Longspur

    USGS Publications Warehouse

    Wild, Teri C.; Kendall, Steven J.; Guldager, Nikki; Powell, Abby N.

    2015-01-01

    Smith's Longspur (Calcarius pictus) is a species of conservation concern which breeds in Arctic habitats that are expected to be especially vulnerable to climate change. We used bird presence and habitat data from point-transect surveys conducted at 12 sites across the Brooks Range, Alaska, 2003–2009, to identify breeding areas, describe local habitat associations, and identify suitable habitat using a predictive model of Smith's Longspur distribution. Smith's Longspurs were observed at seven sites, where they were associated with a variety of sedge–shrub habitats composed primarily of mosses, sedges, tussocks, and dwarf shrubs; erect shrubs were common but sparse. Nonmetric multidimensional scaling ordination of ground cover revealed positive associations of Smith's Longspur presence with sedges and mosses and a negative association with high cover of shrubs. To model predicted distribution, we used boosted regression trees to relate landscape variables to occurrence. Our model predicted that Smith's Longspurs may occur in valleys and foothills of the northeastern and southeastern mountains and in upland plateaus of the western mountains, and farther west than currently documented, over a predicted area no larger than 15% of the Brooks Range. With climate change, shrubs are expected to grow larger and denser, while soil moisture and moss cover are predicted to decrease. These changes may reduce Smith's Longspur habitat quality and limit distribution in the Brooks Range to poorly drained lowlands and alpine plateaus where sedge–shrub tundra is likely to persist. Conversely, northward advance of shrubs into sedge tundra may create suitable habitat, thus supporting a northward longspur distribution shift.

  17. The Edwin Smith papyrus: a clinical reappraisal of the oldest known document on spinal injuries

    PubMed Central

    Sanchez, Gonzalo M.; Burridge, Alwyn L.

    2010-01-01

    Dating from the seventeenth century b.c. the Edwin Smith papyrus is a unique treatise containing the oldest known descriptions of signs and symptoms of injuries of the spinal column and spinal cord. Based on a recent “medically based translation” of the Smith papyrus, its enclosed treasures in diagnostic, prognostic and therapeutic reasoning are revisited. Although patient demographics, diagnostic techniques and therapeutic options considerably changed over time, the documented rationale on spinal injuries can still be regarded as the state-of-the-art reasoning for modern clinical practice. PMID:20697750

  18. Theory of the special Smith-Purcell radiation from a rectangular grating

    SciTech Connect

    Liu, Weihao He, Zhigang Jia, Qika; Li, Weiwei

    2015-12-15

    The recently uncovered special Smith-Purcell radiation (S-SPR) from the rectangular grating has significantly higher intensity than the ordinary Smith-Purcell radiation (SPR). Its monochromaticity and directivity are also much better. Here we explored the mechanism of the S-SPR by applying the fundamental electromagnetic theory and simulations. We have confirmed that the S-SPR is exactly from the radiating eigen modes of the grating. Its frequency and direction are well correlated with the beam velocity and structure parameters, which indicates its promising applications in tunable wave generation and beam diagnostic.

  19. Design of a grating for studying Smith-Purcell radiation and electron acceleration

    SciTech Connect

    Fernow, R.C.

    1989-01-01

    We describe work on the design of a diffraction grating which we intend to use for studying the production of Smith-Purcell radiation and the acceleration of electrons. We have developed computer codes based on the solution of the appropriate Maxwell's equations. A specific grating profile is given which is feasible to construct and which supports enhanced surface accelerating modes. We examine the possibility of using the Smith-Purcell effect to make a beam position monitor. 13 refs., 10 figs., 2 tabs.

  20. Revisiting "No Easy Answers": Application of Sally Smith's Methods in the Lab School of Washington High School Program

    ERIC Educational Resources Information Center

    Reynolds, Meredith

    2010-01-01

    The first edition of "No Easy Answers" (Smith, 1995) was published in 1979, thirty years ago. That seminal work is as relevant today as it was when the book first appeared. This article provides a description of how Sally Smith's Academic Club Method is implemented in the High School program of The Lab School of Washington.

  1. 76 FR 72675 - Voluntary Termination of Foreign-Trade Subzone 90A Smith Corona Corporation, Cortland County, New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Voluntary Termination of Foreign-Trade Subzone 90A Smith Corona Corporation... establishment of Foreign-Trade Subzone 90A at the Smith Corona Corporation plant in Cortland County, New...

  2. 78 FR 31988 - Atomic Safety and Licensing Board; In the Matter of Charlissa C. Smith (Denial of Senior Reactor...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Atomic Safety and Licensing Board; In the Matter of Charlissa C. Smith (Denial of Senior Reactor.... Charlissa Smith's demand for hearing. LBP-13-03, 77 NRC ---- (2013). This hearing will consider Ms....

  3. 77 FR 448 - Changes To Implement the Preissuance Submissions by Third Parties Provision of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... Preissuance Submissions by Third Parties Provision of the Leahy-Smith America Invents Act AGENCY: United... implement the preissuance submissions by third parties provision of the Leahy-Smith America Invents Act. This provision provides a mechanism for third parties to contribute to the quality of issued patents...

  4. "Comments on Coulter and Smith": The Issue of Authorial Surplus in Narrative Research

    ERIC Educational Resources Information Center

    Smith, Michael W.

    2009-01-01

    Advocates of narrative research often contend that it is superior to nonnarrative research, both qualitative and quantitative, because they believe it is better able to represent multiple perspectives and foster multiple interpretations. The author of this comment article on Coulter and Smith (2009) draws on literary theory and an analysis of the…

  5. Adam Smith and the Educative Critique: A Response to My Commentators

    ERIC Educational Resources Information Center

    Weinstein, Jack Russell

    2015-01-01

    This paper is both a response to the four reviewers in a special symposium on my book Adam Smith's Pluralism and a substantive discussion of philosophy of education. In it, I introduce what I call "the educative critique," a mode of analysis similar to Marxist, feminist, or postcolonial critiques, but focusing on the educative role of a…

  6. Sally L. Smith: A Genius at Seeing the Potential in People

    ERIC Educational Resources Information Center

    Edgerton, Mary Allen

    2010-01-01

    What this author admired most about Sally Smith was the fact that she was a visionary about people and what they could accomplish. She saw more potential in a person--young or old--than anybody or even they themselves, frankly, had ever even considered possible. She was a genius at seeing the potential in people, expecting them to find it in…

  7. Differences in Social Motivation in Children with Smith-Magenis Syndrome and Down Syndrome

    ERIC Educational Resources Information Center

    Wilde, Lucy; Mitchell, Anna; Oliver, Chris

    2016-01-01

    Social excesses, characterised by heightened social motivation, are important for describing social functioning. Smith-Magenis syndrome (SMS) is a potential exemplar of a disorder where heightened social motivation is associated with negative behavioural outcomes. In Down syndrome (DS) strong social motivation is described, but less commonly…

  8. Celebrating the Past, Ensuring the Future--A Profile of President Glenn Smith

    ERIC Educational Resources Information Center

    Blumenthal, Anita

    2013-01-01

    "I had no idea how to convince someone to hire me," recalls APPA President, Glen Smith. His first interview was with Bryn Mawr College, a small, prestigious private college with Quaker roots, located 12 miles west of Philadelphia. That was in 1997, after 24 years in the Naval Civil Engineer Corps, and he still remembers a certain…

  9. June 6, 2011 Letter from Shelley Lucas to Stephen Smith and Melissa Waters

    EPA Pesticide Factsheets

    June 6, 2011 Letter from Shelley Lucas to Stephen Smith and Melissa Waters, USEPA, Subject: Response to Information Request Under 92 U.S.C. 9604 to Gannett Co., Inc., Dated March 24, 2011, Regarding Capitol City Plume Site, Montgomery, AL

  10. Another Look at the Glass and Smith Study on Class Size

    ERIC Educational Resources Information Center

    Phelps, James L.

    2011-01-01

    One of the most influential studies affecting educational policy is Glass and Smith's 1978 study, "Meta-Analysis of Research on the Relationship of Class-Size and Achievement." Since its publication, educational policymakers have referenced it frequently as the justification for reducing class size. While teachers and the public had long believed…

  11. 77 FR 58181 - Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request, Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... certificate). Based upon this information, the Secretary will establish an electronic docket for the hearing in this proceeding if the Secretary has not already established an electronic docket. Information... COMMISSION Power Resources, Inc., Smith Ranch Highland Uranium Project; License Renewal Request,...

  12. An Interview with Linda Tuhiwai Te Rina Smith, March 27, 2002.

    ERIC Educational Resources Information Center

    Smith, Linda Tuhiwai Te Rina; Battiste, Marie; Bell, Lynne; Findlay, L. M.

    2002-01-01

    Linda Tuhiwai Te Rina Smith--Maori researcher, educator, and activist--discusses key moments in the journey toward decolonization of Maori education, the impact of her book about decolonizing research methodologies, the concept of postcolonialism, challenges to the sustainability of social and educational change, disrupting the power relation…

  13. Synchrotron emission from dark matter in galactic subhalos. A look into the Smith cloud

    NASA Astrophysics Data System (ADS)

    Leite, N.; Reuben, R.; Sigl, G.; Tytgat, M. H. G.; Vollmann, M.

    2016-11-01

    One of the key predictions of the ``WIMP" paradigm for Dark Matter (DM) is that DM particles can annihilate into charged particles. These annihilations will proceed in e.g. Galactic subhalos such as dwarf Galaxies or, as recently pointed out, high velocity clouds such as the ``Smith Cloud''. In this note, we focus on the radio emission associated with DM annihilations into electrons and positrons occurring in the Smith Cloud. The phenomenology of this emission is discussed in quite some detail. We argue that the uncertainties in the propagation can be captured by the typical diffusion-loss length parameter (Syrovatskii variable) but that the angle-integrated radio fluxes are independent of the propagation. We conclude that if the Smith Cloud is indeed dominated by DM, radio signals from DM annihilation stand out amongst other messengers. Furthermore, low frequencies such as the ones observed by e.g. the Low Frequency Array (LOFAR) and the next-generation Square Kilometre Array (SKA) are optimal for searches for DM in the Smith Cloud. As a practical application, we set conservative constraints on dark matter annihilation cross section using data of continuum radio emission from the Galaxy at 22 MHz and at 1.4 GHz. Stronger constraints could be reached by background subtraction, exploiting the profile and frequency dependence of the putative DM signal. We set stronger but tentative limits using the median noise in brightness temperature from the Green Bank Telescope and the LOFAR sensitivities.

  14. Hidden species complexes within distinctive taxa: the case of Epanthidium bicoloratum (Smith) (Hymenoptera: Megachilidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Epanthidium bicoloratum (Smith) differs from all other Neotropical Anthidiini in the distinctive tegula, which is narrowed posteriorly forming a slender wedge. Examination of material standing under this name revealed that it represents a species complex that includes three new cryptic species, E. ...

  15. Problem Behaviors Associated with Deletion Prader-Willi, Smith-Magenis, and Cri Du Chat Syndromes.

    ERIC Educational Resources Information Center

    Clarke, David J.; Boer, Harm

    1998-01-01

    Problem behaviors of 38 individuals with Cri-du-Chat syndrome, 55 individuals with Prader Willi syndrome, and 21 individuals with Smith-Magenis syndrome were investigated. All three disorders were Associated with greater ratings of problem behaviors (besides eating abnormalities and sleep abnormalities) than comparison groups. (Author/CR)

  16. Chemical composition and biological activity of the essential oil of rhizome of Zingiber zerumbet (L.) smith

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Technical Abstract: The aim was designed to study the biological activity and chemical composition of essential oil of Zingiber zerumbet (L.) Smith. The essential oil extracted from the rhizome of the plant was analysed by gas chromatography-mass spectroscopy and its major components amounting t...

  17. Collection Development Statement for the Reference Collection of the Ethel K. Smith Library, Wingate University.

    ERIC Educational Resources Information Center

    Wetherbee, James M.

    This document is a statement of guidelines for the collection of reference materials at the Ethel K. Smith Library in Wingate University (North Carolina). The library's mission statement is given at the outset. Then parameters are established for the reference collection's scope and size, including subject-area and media priorities. The statement…

  18. Physical origin of the Drude-Smith model for the terahertz conductivity of nanomaterials

    NASA Astrophysics Data System (ADS)

    Baillie, D.; Cocker, T. L.; Buruma, M.; Titova, L. V.; Sydora, R.; Marsiglio, F.; Hegmann, F. A.

    2010-03-01

    While the Drude-Smith model has been shown to describe the terahertz (THz) conductivity in a variety of nanomaterials,^1,2 its validity and physicality have been questioned. We present a refinement to the backscattering interpretation of the Drude-Smith model, which is shown to emerge analytically from a structurally confined Drude gas of electrons. In addition, the modified Drude-Smith model agrees with our Monte Carlo simulations of Brownian particles confined to a box and driven by an external THz field. This simple, classical model for electron transport in nanomaterials not only provides an excellent fit to the observed THz conductivity in films of nanogranular VO2, nanostructured gold, and Si nanocrystals, but also allows for the extraction of meaningful, physically-relevant parameters. Finally, the modified Drude-Smith model as a new effective medium theory is discussed. [1] D G Cooke et al., Phys. Rev. B 73, 193311 (2006). [2] M Walther et al., Phys. Rev. B 76, 125408 (2007).

  19. Quantification of Femoral Neck Exposure Through a Minimally Invasive Smith-Petersen Approach

    DTIC Science & Technology

    2010-06-01

    subcapital, mid cervical , and basicervical femoral neck fractures. Key Words: Smith Petersen, surgical exposure, anterior hip approach, femoral neck...two senior authors (TLG and JRH). These authors are fellowship- trained in arthroplasty and trauma, respectively. A minimally Accepted for publication...intermuscular plane and thus places the superior gluteal nerve at risk. The direct anterior approach was initially used for hip arthroplasty but

  20. 77 FR 71636 - Huntington Foam LLC, Fort Smith, AR; Notice of Revised Determination on Reconsideration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR Employment and Training Administration Huntington Foam LLC, Fort Smith, AR; Notice of Revised Determination on Reconsideration On August 8, 2012, the Department of Labor issued a Notice of Affirmative Determination Regarding Application for...

  1. Translating Frank Smith's Reading Theory into Practice: A Reading Activity for an Exam-Driven Syllabus.

    ERIC Educational Resources Information Center

    Keh, Claudia L.

    1988-01-01

    Smith's approach to reading comprehension is used as the basis of an activity related to the Use of English Exam in Hong Kong. The eight-step activity is described and shown to combine sound reading theory with an academic, test-oriented syllabus. (3 references) (LB)

  2. Comparing Adam Smith's Wealth of Nations to James Madison's Federalist #10.

    ERIC Educational Resources Information Center

    Mundell, Jean

    1987-01-01

    Presents a lesson which calls upon students to compare Adam Smith's WEALTH OF NATIONS to James Madison's FEDERALIST #10 to see how the ancient concept of individual rights and liberties was used to describe both economic and governmental systems. Presents questions to provide the basis for comparison. (GEA)

  3. Back to Beginnings: Credentialism, Productivity, and Adam Smith's Division of Labour.

    ERIC Educational Resources Information Center

    Davis, Denis J.

    1981-01-01

    The foundation of factional pressures for upgrading educational credentials in the labor market is examined through a review of human capital and screening theories. The writings of Adam Smith are referenced to show that the claims of the beneficial effects of educational upgrading have been questioned for 200 years. (Author/MLW)

  4. What's in a Surname? Physique, Aptitude, and Sports Type Comparisons between Tailors and Smiths.

    PubMed

    Voracek, Martin; Rieder, Stephan; Stieger, Stefan; Swami, Viren

    2015-01-01

    Combined heredity of surnames and physique, coupled with past marriage patterns and trade-specific physical aptitude and selection factors, may have led to differential assortment of bodily characteristics among present-day men with specific trade-reflecting surnames (Tailor vs. Smith). Two studies reported here were partially consistent with this genetic-social hypothesis, first proposed by Bäumler (1980). Study 1 (N = 224) indicated significantly higher self-rated physical aptitude for prototypically strength-related activities (professions, sports, hobbies) in a random sample of Smiths. The counterpart effect (higher aptitude for dexterity-related activities among Tailors) was directionally correct, but not significant, and Tailor-Smith differences in basic physique variables were nil. Study 2 examined two large total-population-of-interest datasets (Austria/Germany combined, and UK: N = 7001 and 20,532) of men's national high-score lists for track-and-field events requiring different physiques. In both datasets, proportions of Smiths significantly increased from light-stature over medium-stature to heavy-stature sports categories. The predicted counterpart effect (decreasing prevalences of Tailors along these categories) was not supported. Related prior findings, the viability of possible alternative interpretations of the evidence (differential positive selection for trades and occupations, differential endogamy and assortative mating patterns, implicit egotism effects), and directions for further inquiry are discussed in conclusion.

  5. Whatever Happened to the Supervisor of the Smith-Hughes Man?

    ERIC Educational Resources Information Center

    Hillison, John

    1999-01-01

    Formal supervision of agricultural education teachers by state supervisors began with the 1917 Smith-Hughes Act. Supervision has evolved from the "iron fist" to the consultant. Some felt that supervisors usurped the role of teacher educators. By the end of the 20th century, supervision had devolved to local administrators and vocational…

  6. History of Extension Work in Virginia Prior to Smith-Lever.

    ERIC Educational Resources Information Center

    Hillison, John; Sutphin, Cathy M.

    1999-01-01

    Before the Smith-Lever Act of 1914, agricultural schools begun in 11 Virginia congressional districts in 1908 performed a great deal of extension work, such as agricultural demonstrations, youth activities, and home economics programs. This helped pave the way for formal extension programs established by the legislation. (SK)

  7. The Coalition that Supported the Smith-Hughes Act or a Case for Strange Bedfellows.

    ERIC Educational Resources Information Center

    Hillison, John

    1995-01-01

    A coalition led by the National Society for Promotion of Industrial Education gained passage of the Smith-Hughes Act in 1917, but natural antagonisms quickly dissolved it. The coalition included unions, manufacturers, professional educators, political parties, farmers' groups, and home economics groups. This diverse group's accomplishment is a…

  8. 3. Photocopy of illustration from J. Smith Futhey's Historical Discourse....of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Photocopy of illustration from J. Smith Futhey's Historical Discourse....of the Upper Octoraro Presbyterian Church, Philadelphia, 1870 SHOWS CHURCH WITH SESSIONS HOUSE IN BACKGROUND - Upper Octoraro Presbyterian Church Session House, State Route 10 & Octoraro Road (Sadsbury Township), Parkesburg, Chester County, PA

  9. 78 FR 59368 - Notice of Joint Meeting for Captain John Smith Chesapeake National Historic Trail Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... Advisory Council and Star-Spangled Banner National Historic Trail Advisory Council AGENCY: National Park... John Smith Chesapeake National Historic Trail and the Star-Spangled Banner National Historic Trail will.... The Star-Spangled Banner National Historic Trail consists of ``water and overland routes...

  10. 78 FR 15747 - Charlissa C. Smith (Denial of Senior Reactor Operator License)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Charlissa C. Smith (Denial of Senior Reactor Operator License) Notice of Atomic Safety and Licensing Board Reconstitution Pursuant to 10 CFR 2.313(c) and 2.321(b), the Atomic Safety and...

  11. 78 FR 16286 - Neal Smith National Wildlife Refuge, Jasper County, IA; Final Comprehensive Conservation Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service Neal Smith National Wildlife Refuge, Jasper County, IA; Final Comprehensive Conservation Plan and Finding of No Significant Impact for Environmental Assessment AGENCY: Fish and...

  12. 77 FR 50155 - Neal Smith National Wildlife Refuge, Jasper County, IA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Fish and Wildlife Service Neal Smith National Wildlife Refuge, Jasper County, IA AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of availability; request for comments. SUMMARY: We, the...

  13. 76 FR 53961 - Harold Edward Smith, M.D.; Revocation Of Registration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... Enforcement Administration Harold Edward Smith, M.D.; Revocation Of Registration On April 17, 2009, the Deputy... proposed the revocation of Respondent's DEA Certificate of Registration, BS4681979, and the denial of any pending applications to renew or modify the registration, on the grounds that Respondent had...

  14. ESTIMATION OF SURPLUS BIOMASS OF CLUPEIDS IN SMITH MOUNTAIN LAKE, VIRGINIA

    EPA Science Inventory

    Mean annual estimates of surplus biomass of alewife Alosa pseudoharengus and gizzard shad Dorosoma cepedianum in Smith Mountain Lake, Virginia, were calculated using data on the biomass, growth, and mortality of each clupeid species. Surplus biomass, defined as production over a...

  15. MASTER BATH. VIEW FACING EAST Camp H.M. Smith and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    MASTER BATH. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Three-Bedroom Duplex Type 2, Acacia Road, Birch Circle, and Cedar Drive, Pearl City, Honolulu County, HI

  16. Back to the Future on Gender and Anti-School Boys: A Response to Jeffrey Smith

    ERIC Educational Resources Information Center

    Abraham, John

    2008-01-01

    This article examines recent claims by Jeffrey Smith that: (1) "hegemonic masculinity" is an expression of working class counter-school culture; (2) some teachers are "cultural accomplices" in constructing "hegemonic masculinities" of anti-school working class boys, thereby contributing to their underachievement; and (3) these "cultural…

  17. Development and Behaviour in Marshall-Smith Syndrome: An Exploratory Study of Cognition, Phenotype and Autism

    ERIC Educational Resources Information Center

    van Balkom, I. D. C.; Shaw, A.; Vuijk, P. J.; Franssens, M.; Hoek, H. W.; Hennekam, R. C. M.

    2011-01-01

    Background: Marshall-Smith syndrome (MSS) is an infrequently described entity characterised by failure to thrive, developmental delay, abnormal bone maturation and a characteristic face. In studying the physical features of a group of patients, we noticed unusual behavioural traits. This urged us to study cognition, behavioural phenotype and…

  18. On `a model of impulsive loop flares revisted' by Smith and Brecht

    NASA Astrophysics Data System (ADS)

    Takakura, Tatsuo

    1995-01-01

    A criticism of my papers was recently presented by Smith and Brecht, that the electron distribution resulting from anaomalous heat conduction is not unstable for electron plasma waves. The aim of the present letter is to show that their criticism is irrelevant.

  19. A Case Study of Early Development in Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Fidler, Deborah J.; Philofsky, Amy D.; Hepburn, Susan L.

    2006-01-01

    The aim of this article is to provide an in-depth description of early development in a young child with Smith-Magenis syndrome (SMS). SMS is a multisystem, neurodevelopmental genetic disorder associated with mental retardation that predisposes individuals to a distinct pattern of maladaptive behaviors and other neuropsychological impairments.…

  20. World of John and Mary Smith: A Study of Quirk and Greenbaum's "University Grammar of English."

    ERIC Educational Resources Information Center

    Stephens, Kate

    This paper analyzes the "University Grammar of English" by Randolph Quirk and Sidney Greenbaum (1973) from the point of view of isolation of forms of language from meaning used to convey these forms, especially regarding gender differences and relations in the main characters, John and Mary Smith. It is suggested that females are underrepresented,…

  1. LIFE HISTORY MONITORING OF SALMONIDS IN THE WEST FORK SMITH RIVER, UMPQUA BASIN, OREGON

    EPA Science Inventory

    As a life-cycle monitoring basin for the Oregon Salmon Plan, the Oregon Department of Fish and Wildlife has estimated adult returns, distribution and smolt outmigration of coho, chinook and winter steelhead in the West Fork Smith River since 1998. In 2001/2002, the Environmenta...

  2. 2. Photocopied October 1976, from b.f smithIllistrations of the Croton ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Photocopied October 1976, from b.f smithIllistrations of the Croton Aqueduct, New York, Wiley and Putnam, 1843. TITLE PAGE. SHOWS N.Y.C. FOUNTAIN MADE POSSIBLE BY THE AQUEDUCT. - Old Croton Aqueduct, New York County, NY

  3. 76 FR 26767 - Captain John Smith Chesapeake National Historic Trail Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... to the National Trails System Act (16 U.S.C. 1241), the trail consists of ``a series of water routes... Memorial Conference Room (Fish Shack), 410 Severn Avenue, Annapolis, MD 21403. For more information, please... INFORMATION CONTACT: Christine Lucero, Partnership Coordinator for the Captain John Smith Chesapeake...

  4. Headed in the Right Direction: A Commentary on Yoshida and Smith

    ERIC Educational Resources Information Center

    Aslin, Richard N.

    2008-01-01

    Yoshida and Smith (this issue) provide one of the first attempts to overcome the most serious impediment to the use of head-mounted eye trackers with infants: Except in rare cases they are not light enough to be worn on an infant's head, or the infant does not tolerate looking through a half-silvered mirror that is hanging on a rigid stalk…

  5. "Comments on Coulter and Smith": Relational Ontological Commitments in Narrative Research

    ERIC Educational Resources Information Center

    Clandinin, D. Jean; Murphy, M. Shaun

    2009-01-01

    In this comment article on Coulter and Smith (2009), the authors raise concerns that focusing exclusively on issues of representation may lead readers to misunderstandings about narrative research. The authors argue that narrative ways of thinking about the phenomena under study are interwoven with narrative research methodologies. Drawing on…

  6. "Comments on Coulter and Smith": Narrative Researchers as Witnesses of Injustice and Agents of Social Change?

    ERIC Educational Resources Information Center

    Barone, Tom

    2009-01-01

    In commenting on Coulter and Smith (2009), the author explores issues related to the place of the political in education research and in literature, but especially in forms of narrative research that possess both scientific and literary dimensions. More specifically, the author examines four sets of issues related to the researching and writing of…

  7. OCLC Looks to an Online Future: An Interview with K. Wayne Smith.

    ERIC Educational Resources Information Center

    Arnold, Stephen

    1993-01-01

    Provides an interview with K. Wayne Smith, chief executive officer of OCLC, that focuses on OCLC's online reference services. Topics include the ratio between technical and online reference services, how OCLC fits into the online industry, telecommunications, electronic publishing, pricing, database tape leases, and CD-ROM. (EAM)

  8. Adaptive and Maladaptive Behavior in Children with Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Martin, Staci C.; Wolters, Pamela L.; Smith, Ann C. M.

    2006-01-01

    Children with Smith-Magenis Syndrome (SMS) exhibit deficits in adaptive behavior but systematic studies using objective measures are lacking. This descriptive study assessed adaptive functioning in 19 children with SMS using the Vineland Adaptive Behavior Scales (VABS). Maladaptive behavior was examined through parent questionnaires and the…

  9. Stress in Families of Young Children with Down Syndrome, Williams Syndrome, and Smith-Magenis Syndrome.

    ERIC Educational Resources Information Center

    Fidler, Deborah J.; Hodapp, Robert M.; Dykens, Elizabeth M.

    2000-01-01

    Compared stress levels in families of children with Down syndrome (DS), Williams syndrome (WS), or Smith-Magenis syndrome (SMS). Found that DS families experienced less Pessimism than others and less Parent and Family Problems than SMS families. Strongest predictors of Parent and Family Problems were maladaptive behavior in SMS, younger age in DS,…

  10. Prevalence, Phenomenology, Aetiology and Predictors of Challenging Behaviour in Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Sloneem, J.; Oliver, C.; Udwin, O.; Woodcock, K. A.

    2011-01-01

    Background: The prevalence, phenomenology aetiology and correlates of four forms of challenging behaviour in 32 children and adults with Smith-Magenis syndrome (SMS) were investigated. Methods: Cognitive assessments, questionnaires and semi-structured interviews were used to gather data on intellectual disability, verbal and physical aggression,…

  11. Characterization of Self-Injurious Behaviors in Children and Adults with Smith-Magenis Syndrome.

    ERIC Educational Resources Information Center

    Finucane, Brenda; Dirrigl, Karen Haines; Simon, Elliot W.

    2001-01-01

    This study examined the prevalence and severity of self-injurious behavior (SIB) in 29 children and adults with Smith-Magenis syndrome, a genetic disorder usually involving moderate mental retardation. Findings confirmed the near universal presence of SIB in this population. The overall prevalence of SIB increased with age. Number of types of SIB…

  12. Brief Report: Cognitive and Behavioral Profiles in Persons with Smith-Magenis Syndrome.

    ERIC Educational Resources Information Center

    Dykens, Elisabeth M.; And Others

    1997-01-01

    A study examined the cognitive and behavioral profiles in 10 individuals (ages 14-51) with Smith-Magenis syndrome. Results found the individuals showed significant relative weaknesses in sequential processing and strengths in naming a partially completed drawing, identifying things, and in reading/decoding. Behavioral findings indicated…

  13. Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Hildenbrand, Hanna L.; Smith, Ann C. M.

    2012-01-01

    This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

  14. What’s in a Surname? Physique, Aptitude, and Sports Type Comparisons between Tailors and Smiths

    PubMed Central

    Voracek, Martin; Rieder, Stephan; Stieger, Stefan; Swami, Viren

    2015-01-01

    Combined heredity of surnames and physique, coupled with past marriage patterns and trade-specific physical aptitude and selection factors, may have led to differential assortment of bodily characteristics among present-day men with specific trade-reflecting surnames (Tailor vs. Smith). Two studies reported here were partially consistent with this genetic-social hypothesis, first proposed by Bäumler (1980). Study 1 (N = 224) indicated significantly higher self-rated physical aptitude for prototypically strength-related activities (professions, sports, hobbies) in a random sample of Smiths. The counterpart effect (higher aptitude for dexterity-related activities among Tailors) was directionally correct, but not significant, and Tailor-Smith differences in basic physique variables were nil. Study 2 examined two large total-population-of-interest datasets (Austria/Germany combined, and UK: N = 7001 and 20532) of men’s national high-score lists for track-and-field events requiring different physiques. In both datasets, proportions of Smiths significantly increased from light-stature over medium-stature to heavy-stature sports categories. The predicted counterpart effect (decreasing prevalences of Tailors along these categories) was not supported. Related prior findings, the viability of possible alternative interpretations of the evidence (differential positive selection for trades and occupations, differential endogamy and assortative mating patterns, implicit egotism effects), and directions for further inquiry are discussed in conclusion. PMID:26161803

  15. Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa.

    PubMed

    Ellison, Damon W; Clark, Tina R; Sturdevant, Daniel E; Virtaneva, Kimmo; Porcella, Stephen F; Hackstadt, Ted

    2008-02-01

    Rickettsia rickettsii is an obligate intracellular pathogen that is the causative agent of Rocky Mountain spotted fever. To identify genes involved in the virulence of R. rickettsii, the genome of an avirulent strain, R. rickettsii Iowa, was sequenced and compared to the genome of the virulent strain R. rickettsii Sheila Smith. R. rickettsii Iowa is avirulent in a guinea pig model of infection and displays altered plaque morphology with decreased lysis of infected host cells. Comparison of the two genomes revealed that R. rickettsii Iowa and R. rickettsii Sheila Smith share a high degree of sequence identity. A whole-genome alignment comparing R. rickettsii Iowa to R. rickettsii Sheila Smith revealed a total of 143 deletions for the two strains. A subsequent single-nucleotide polymorphism (SNP) analysis comparing Iowa to Sheila Smith revealed 492 SNPs for the two genomes. One of the deletions in R. rickettsii Iowa truncates rompA, encoding a major surface antigen (rickettsial outer membrane protein A [rOmpA]) and member of the autotransporter family, 660 bp from the start of translation. Immunoblotting and immunofluorescence confirmed the absence of rOmpA from R. rickettsii Iowa. In addition, R. rickettsii Iowa is defective in the processing of rOmpB, an autotransporter and also a major surface antigen of spotted fever group rickettsiae. Disruption of rompA and the defect in rOmpB processing are most likely factors that contribute to the avirulence of R. rickettsii Iowa. Genomic differences between the two strains do not significantly alter gene expression as analysis of microarrays revealed only four differences in gene expression between R. rickettsii Iowa and R. rickettsii strain R. Although R. rickettsii Iowa does not cause apparent disease, infection of guinea pigs with this strain confers protection against subsequent challenge with the virulent strain R. rickettsii Sheila Smith.

  16. The Adventures of Captain John Smith, Pocahontas and a Sundial: Cosmology, Mathematics, and Power at the Time of Jamestown

    NASA Astrophysics Data System (ADS)

    Schechner, Sara J.

    2007-12-01

    While exploring the Chickahominy River in Virginia by canoe in December 1607, Captain John Smith was ambushed by 200 Powhatan Indians and chased into the swamp. Wounded by arrows and mired in the cold mud, Smith surrendered and was led to their chieftain, Opechancanough. Smith played for time. He pulled out his pocket sundial and proceeded to deliver a lecture on astronomy. The Indians marveled at the dancing needle of the magnetic compass, which they could plainly see but not touch because of the glass cover. They apparently thought less of his discourse in a foreign language on the sun, moon, and planets, as within the hour, Smith's captors had him tied to a tree and were ready to shoot him. But then, Opechancanough held the sundial aloft and spared Smith's life. For the next month, Smith was paraded around various Indian villages before being condemned to have his head bashed in. Pocahontas, however, threw herself across Smith's body in order to save his life. This legendary episode reveals more than Smith's ingenuity. His compass sundial, shaped and marked like a celestial globe, was a microcosm of his universe. It embodied the belief that the smallest things mirrored the large, that number was the key to God's creation, and that by means of mathematical instruments, men could dominate that world (or at least extricate themselves from tight spots!). This paper will examine the astronomical ideas and instruments on which these beliefs were based, and show how ultimately, Smith's sundial also represented the clash of two cosmologies-that of the Indians and European settlers.

  17. Coherent and tunable light radiation from nanoscale surface plasmons array via an exotic Smith-Purcell effect.

    PubMed

    Liu, Weihao

    2015-10-15

    We demonstrate that surface plasmons on a nanoscale metallic array can be transformed into radiation waves via an exotic Smith-Purcell effect. Although the radiation frequency and direction satisfy the Smith-Purcell relation, it is coherent radiation with directions specified, which is essentially different from the ordinary Smith-Purcell radiation. Its radiation spectral density is an order of magnitude higher. By adjusting the material and structure of the array, the radiation frequency can be tuned from an infrared to ultraviolet region. Its remarkable advantages in intensity, coherence, tunability, and miniature size indicate new prospects in developing nanoscale light sources and related techniques.

  18. Efficacy of Fewer than Three Doses of an HPV-16/18 AS04 adjuvanted Vaccine: Combined Analysis of Data from the Costa Rica Vaccine Trial and the PATRICIA Trial

    PubMed Central

    Kreimer, Aimée R; Struyf, Frank; Del Rosario-Raymundo, Maria Rowena; Hildesheim, Allan; Skinner, S Rachel; Wacholder, Sholom; Garland, Suzanne M; Herrero, Rolando; David, Marie-Pierre; Wheeler, Cosette M

    2015-01-01

    and two dose(s) of the HPV16/18 vaccine appear to protect against cervical HPV16/18 infections, similar to the protection provided by the three-dose schedule. Two doses separated by six months additionally provided limited cross-protection. These data argue for a direct evaluation of one-dose efficacy of the HPV16/18 vaccine. Funding The CVT trial was sponsored and funded by the US National Cancer Institute, NCI (contract N01-CP-11005), with funding support from the National Institutes of Health Office of Research on Women’s Health, and done with the support from the Ministry of Health of Costa Rica. Vaccine was provided for CVT by GlaxoSmithKline Biologicals SA, under a Clinical Trials Agreement with the NCI. GlaxoSmithKline Biologicals SA provided support for aspects of the trial associated with regulatory submission needs of the company under US Food and Drug Administration BB-IND 7920. The PATRICIA trial was sponsored by GlaxoSmithKline Biologicals SA. PMID:26071347

  19. Monte Carlo calculations and experimental setup for a Smith-Purcell experiment in Bucharest and Athens

    NASA Astrophysics Data System (ADS)

    Karabarbounis, A.; Papadakis, J.; Stiliaris, E.; Trikalinos, Ch.; Scarlat, F.; Facina, M.; Dinca, C. D.; Manu, V.

    2001-01-01

    A study of energy spectra (Smith-Purcell power, energy peaks, and shape of the spectra) is performed using a Monte Carlo simulation method. This was done in order to examine the dependence from the experimental parameters. The setup for an experiment looking for Smith-Purcell radiation in the IR and FIR region is also presented. Experiment is taking place at the beginning of year 2000 in Bucharest (Romania) at the National Institute for Laser, Plasma and Radiation Physics, at the betatron facilities of the Electron Accelerator Laboratory with an electron beam up to 30 MeV. This experiment will be continued later on in Athens (Greece), at the Institute of Accelerating Systems and Applications (IASA) with a linac delivering up to 10 MeV CW electron beam.

  20. Dispersion characteristics of planar grating with arbitrary grooves for terahertz Smith-Purcell radiation

    SciTech Connect

    Cao, Miaomiao Li, Ke; Liu, Wenxin Wang, Yong

    2015-03-15

    In this paper, a novel method of getting the dispersion relations in planar grating with arbitrary grooves for terahertz Smith-Purcell radiation is investigated analytically. The continuous profile of the groove is approximately replaced by a series of rectangular steps. By making use of field matches method and the continuity of transverse admittance, the universal dispersion equation for grating with arbitrarily shaped grooves is derived. By solving the dispersion equation in presence of electron beam, the growth rate is obtained directly and the dependence on beam parameters is analyzed. Comparisons of the dispersion characteristics among some special groove shapes have been made by numerical calculation. The results show that the rectangular-step approximation method provides a novel approach to obtain the universal dispersion relation for grating with arbitrary grooves for Smith-Purcell radiation.

  1. Finding revelation in anthropology: Alexander Winchell, William Robertson Smith and the heretical imperative.

    PubMed

    Livingstone, David N

    2015-09-01

    Anthropological inquiry has often been considered an agent of intellectual secularization. Not least is this so in the sphere of religion, where anthropological accounts have often been taken to represent the triumph of naturalism. This metanarrative, however, fails to recognize that naturalistic explanations could sometimes be espoused for religious purposes and in defence of confessional creeds. This essay examines two late nineteenth-century figures--Alexander Winchell in the United States and William Robertson Smith in Britain--who found in anthropological analysis resources to bolster rather than undermine faith. In both cases these individuals found themselves on the receiving end of ecclesiastical censure and were dismissed from their positions at church-governed institutions. But their motivation was to vindicate divine revelation, in Winchell's case from the physical anthropology of human origins and in Smith's from the cultural anthropology of Semitic ritual.

  2. DNA evidence in rape cases and the Debbie Smith Act: forensic practice and criminal justice implications.

    PubMed

    Telsavaara, Terhi V T; Arrigo, Bruce A

    2006-10-01

    The Debbie Smith or "Justice for All" Act was passed on November 1, 2004. The act addresses the problem of collecting and analyzing DNA evidence from backlogged rape kits sitting in crime laboratories around the country. Presently, no empirical data exist by which to assess the soundness of the legislation. However, the act clearly affects discrete operations within the forensic and criminal justice systems. This article explores the relative merits of the Debbie Smith law, highlighting changes in Sexual Assault Nurse Examiner (SANE) programs, law enforcement, court administration, correctional treatment, and juvenile justice practices. Concerns linked to the likely impact of the "Justice for All" Act raise significant questions about its overall programmatic utility and treatment efficacy.

  3. Estimated transportation routes to a candidate salt repository site in Deaf Smith County, Texas

    SciTech Connect

    Joy, D.S.; Johnson, P.E.

    1987-10-01

    This report presents a preliminary analysis of possible highway and rail transportation routes within Texas, Oklahoma, and New Mexico for shipments of spent fuel to the candidate repository site in Deaf Smith County, Texas. Two cases are examined for highway shipments. The initial case analyzes shipments following the Department of Transportation's HM-164 regulations for shipment of spent fuel. The second case analyzes normal commercial routes. Three rail cases are also examined. Each case analyzes potential routes that would be used based for different access spurs into the repository site. Two appendices are included which examine additional scenarios generated by restricting routes from passing through various metropolitan areas. The major finding is that most shipments to the Deaf Smith site will pass through Amarillo, Texas. There are few, if any, feasible alternative routes which would significantly reduce the amount of traffic passing through Amarillo.

  4. Rival ecologies of global commerce: Adam Smith and the natural historians.

    PubMed

    Jonsson, Fredrik Albritton

    2010-01-01

    This essay explores how the defense of global commerce pioneered in the Enlightenment was tied to the improvement of the natural order. Two rival ecologies, one made by natural historians and the other developed by Adam Smith and his liberal successors, vied for intellectual precedence as well as for practical application in the metropole and the colonies. Together they constitute the beginnings of an ongoing quarrel over the environmental foundation of capitalism.

  5. Additional dates of Sir Andrew Smith's Illustrations of the Zoology of South Africa.

    PubMed

    Low, Martyn E Y; Evenhuis, Neal L

    2014-05-14

    We update the collation of the dates of publication of Smith's Illustrations of the Zoology of South Africa provided by Waterhouse (1880) and Barnard (1950, 1952). In the case of nine parts, we are able to provide more accurate dates of publication (including day-dates for seven of these parts). For workers of invertebrate taxonomy, we provide an accurate date of publication for W. S. Macleay's volume on Annulosa. 

  6. Water-quality data for Smith and Bybee Lakes, Portland, Oregon, June to November, 1982

    USGS Publications Warehouse

    Clifton, Daphne G.

    1983-01-01

    Water-quality monitoring at Smith and Bybee Lakes included measurement of water temperature, dissolved oxygen concentration and percent saturation, pH, specific conductance, lake depth, alkalinity, dissolved carbon, total dissolved solids, secchi disk light transparency, nutrients, and chlorophyll a and b. In addition, phytoplankton, zooplankton, and benthic invertebrate populations were identified and enumerated. Lakebed sediment was analyzed for particle size, volatile solids, immediate oxygen demand, trace metals, total organic carbon, nutrients, and organic constituents. (USGS)

  7. Energy conservation study on Smith Frozen Foods processing plant, Weston, Oregon

    SciTech Connect

    Not Available

    1985-01-02

    A comprehensive energy study was performed at Smith Frozen Foods in Weston, Oregon, in the fall of 1984. The plant processes corn, peas, lima beans and carrots. The products are inspected, prepared and graded before being sent through freeze tunnels. The frozen products are dumped into tote bins which are transported into cold storage warehouses. Energy conservation measures were calculated using a modified return on investment analysis called a return on capital (ROC) analysis and current rate schedules.

  8. Stroke after cardiac surgery in a patient with Smith-Magenis syndrome.

    PubMed

    Chaudhry, Alyas P; Schwartz, Carl; Singh, Arun K

    2007-01-01

    Patients with Smith-Magenis syndrome have a high incidence of congenital heart disease that requires open-heart surgery. These patients may have gene deletions that affect cholesterol homeostasis, although no previous association has been made with premature atherosclerosis. Herein, we report a case of such a patient, who experienced a stroke after cardiac surgery because of what we believe to be premature intracerebral atherosclerosis.

  9. An efficient and high performance linear recursive variable expansion implementation of the Smith-Waterman algorithm.

    PubMed

    Hasan, Laiq; Al-Ars, Zaid

    2009-01-01

    In this paper, we present an efficient and high performance linear recursive variable expansion (RVE) implementation of the Smith-Waterman (S-W) algorithm and compare it with a traditional linear systolic array implementation. The results demonstrate that the linear RVE implementation performs up to 2.33 times better than the traditional linear systolic array implementation, at the cost of utilizing 2 times more resources.

  10. An appreciation of Robert Moors Smith MD, an icon of pediatric anesthesiology.

    PubMed

    Holzman, Robert S

    2010-08-01

    Robert Moors Smith M.D. passed away recently at the age of 97. During his chairmanship of the Department of Anesthesiology at Children's Hospital Boston from 1946 to 1980 he gained world prominence for his contributions to the anesthetic care of children and the education of generations of pediatric anesthesiologists. His dedicated and earnest approach, reflected in tribute and in his own words, provide a window on pediatric anesthesia during its development into a recognized subspecialty in the 20th century.

  11. Obwervation of 10 {mu}m Smith-Purcell radiation from 45 MeV electrons

    SciTech Connect

    Fernow, R.C.; Robertson, S.H.; Brownell, J.H.; Walsh, J.E.

    1997-02-01

    Using the high-brightness, high-energy electron beam at the Brookhaven Accelerator Test Facility we observe forward directed Smith-Purcell radiation in the mid-infrared spectral regime. This radiation can prove useful as a source of infrared radiation for other scientific studies as well as a providing a precursor investigation of the inverse process, namely the acceleration of electrons by means of the coupling of laser light with electrons via micro-structures.

  12. Biotransformation of dehydroepiandrosterone (DHEA) with Penicillium griseopurpureum Smith and Penicillium glabrum (Wehmer) Westling.

    PubMed

    Huang, Li-Hua; Li, Juan; Xu, Gong; Zhang, Xiang-Hua; Wang, Yang-Guang; Yin, Ye-Lin; Liu, Hong-Min

    2010-12-12

    Microbial transformation of dehydroepiandrosterone (DHEA, 1) using Penicillium griseopurpureum Smith and Penicillium glabrum (Wehmer) Westling has been investigated. Neither fungi had been examined previously for steroid biotransformation. One novel metabolic product of DHEA (1) transformed with P. griseopurpureum Smith, 15α-hydroxy-17a-oxa-d-homo-androst-4-ene-3,17-dione (5), was reported for the first time. The steroid products were assigned by interpretation of their spectral data such as (1)H NMR, (13)C NMR, IR, and HR-MS spectroscopy. P. griseopurpureum Smith was proven to be remarkably efficient in oxidation of the DHEA (1) into androst-4-en-3,17-dione (2). The strain was also observed to yield different monooxygenases to introduce hydroxyl groups at C-7α, -14α, and -15α positions of steroids. Preference for Baeyer-Villiger oxidation to lactonize D ring and oxidation of the 3β-alcohol to the 3-ketone were observed in both incubations. The strain of P. glabrum (Wehmer) Westling catalyzed the steroid 1 to generate both testololactone 3, and d-lactone product with 3β-hydroxy-5-en moiety 8. In addition, the strain promoted hydrogenation of the C-5 and C-6 positions, leading to the formation of 3β-hydroxy-17a-oxa-d-homo-5α-androstan-3,17-dione (9). The biotransformation pathways of DHEA (1) with P. glabrum (Wehmer) Westling and P. griseopurpureum Smith have been investigated, respectively. Possible metabolic pathways of DHEA (1) were proposed.

  13. Psychiatric disorder and suicide in the military, then and now: commentary on Frueh and Smith.

    PubMed

    McNally, Richard J

    2012-10-01

    Consulting archival medical data from the American Civil War, Frueh and Smith found little evidence of mental disorders, no evidence of reexperiencing symptoms suggestive of posttraumatic stress disorder, but a notable rate of suicide. In this commentary, I suggest reasons why the archives contain so few traces of combat-related disorders despite the massive trauma experienced by soldiers in the Civil War, and I draw implications for military personnel returning from the wars in Iraq and Afghanistan.

  14. Efficacy of risperidone treatment in Smith-Magenis syndrome (del 17 pll. 2).

    PubMed

    Niederhofer, Helmut

    2007-09-01

    Smith-Magenis syndrome (SMS) is a clinically recognizable multiple congenital anomaly and mental retardation syndrome caused by an interstitial deletion of chromosome 17 pll.2. Although the physical and molecular genetic features of SMS are increasingly well understood, work is more limited on SMS's behavioral phenotype, which includes self-injury, tantrums, aggression, attention deficit, and sleep disturbance. This case-report describes the lowering of the aggression level of a 13 year old individual with SMS.

  15. The Smith Stream: A High Velocity Cloud crossing the Milky Way Disk

    NASA Astrophysics Data System (ADS)

    Lockman, Felix J.

    2012-05-01

    The Smith Cloud is a high-velocity HI cloud with the following extraordinary properties: it is located about 12 kpc from the Sun but less than 8 kpc from the Galactic Center, and it's tip is currently about 2 kpc below the Galactic plane. Its complete space motion is known and it is on a trajectory to cross the Galactic plane in about 30 Myr. Its size is >3 x >1 kpc, and it contains more than two million solar masses of ionized and neutral Hydrogen. Recent new HI observations with the NRAO Green Bank Telescope have revealed a series of small HI clouds over an area ahead of the Smith Cloud that have kinematics and locations consistent with following the same trajectory as the Cloud. Their spectra suggests that they are interacting strongly with the local ISM. The implication is that that the Smith Cloud is the largest object along a stream of gas more than 6 kpc in extent, some of which has already passed through the Galactic plane. The National Radio Astronomy Observatory is a facility of the National Science Foundation, operated under a cooperative agreement by Associated Universities, Inc.

  16. Smith's Cloud: A High Velocity HI Cloud Entering The Galactic Disk

    NASA Astrophysics Data System (ADS)

    Lockman, Felix J.; Benjamin, R. A.; Heroux, A.; Langston, G. I.

    2007-12-01

    HI observations using the Green Bank Telescope at 21cm of the high-velocity cloud known as Smith's Cloud show that it has a large, cometary morphology pointing toward the Galactic disk, and shows clear signs of interaction with the Milky Way. From the velocity range of the interaction we can estimate the rest velocity of the ambient medium into which Smith's Cloud moves. This gives a kinematic distance to the interaction site of 12 kpc, a value which is essentially identical to other distance estimates for the cloud. The main portion of Smith's Cloud is located about 3 kpc below the Galactic plane and only 7.6 kpc from the Galactic center. Its total extent is more than 3 kpc. It is bring more than a million solar masses of gas to the star-forming regions of the inner Galaxy. From the projected differential velocity of the cloud we can estimate its trajectory: its total space velocity appears to be at least 275 km/s and it has a peculiar velocity with respect to its environment of at least 95 km/s.

  17. Acceleration of the Smith-Waterman algorithm using single and multiple graphics processors

    NASA Astrophysics Data System (ADS)

    Khajeh-Saeed, Ali; Poole, Stephen; Blair Perot, J.

    2010-06-01

    Finding regions of similarity between two very long data streams is a computationally intensive problem referred to as sequence alignment. Alignment algorithms must allow for imperfect sequence matching with different starting locations and some gaps and errors between the two data sequences. Perhaps the most well known application of sequence matching is the testing of DNA or protein sequences against genome databases. The Smith-Waterman algorithm is a method for precisely characterizing how well two sequences can be aligned and for determining the optimal alignment of those two sequences. Like many applications in computational science, the Smith-Waterman algorithm is constrained by the memory access speed and can be accelerated significantly by using graphics processors (GPUs) as the compute engine. In this work we show that effective use of the GPU requires a novel reformulation of the Smith-Waterman algorithm. The performance of this new version of the algorithm is demonstrated using the SSCA#1 (Bioinformatics) benchmark running on one GPU and on up to four GPUs executing in parallel. The results indicate that for large problems a single GPU is up to 45 times faster than a CPU for this application, and the parallel implementation shows linear speed up on up to 4 GPUs.

  18. 77 FR 34337 - Uinta-Wasatch-Cache National Forest; Evanston-Mountain View Ranger District; Utah; Smiths Fork...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Uinta-Wasatch-Cache National Forest; Evanston-Mountain View Ranger District; Utah; Smiths... format. FOR FURTHER INFORMATION CONTACT: Pete Gomben, Environmental Coordinator for the...

  19. ONWI (Office of Nuclear Waste Isolation) 30% design review findings report for Exploratory Shaft Facility, Deaf Smith site

    SciTech Connect

    Not Available

    1987-05-08

    This document describes a review of the standards for the design of the high-level radioactive waste facility at the Deaf Smith, Texas site. It includes public comments and the official responses to the designs produced to date. (TEM)

  20. The Edwin Smith Papyrus: the birth of analytical thinking in medicine and otolaryngology.

    PubMed

    Stiefel, Marc; Shaner, Arlene; Schaefer, Steven D

    2006-02-01

    The Edwin Smith Papyrus, discovered in 1862 outside of Luxor, Egypt, is the oldest known surgical text in the history of civilization. The surviving scroll, a copy of an earlier text from around 3,000 B.C., gives us remarkable insight into the medical practice of ancient Egyptians in the Nile River bed during the dawn of civilization. The Papyrus is divided into 48 cases, most of which describe traumatic injuries. The text instructs the physician to examine the patient and look for revealing physical signs that may indicate the outcome of the injury. Although in modern medicine we take for granted that the use of physical examination and rational thinking lead to an accurate conclusion, 5,000 years ago, this was extraordinary. The Edwin Smith Papyrus cast aside the prevailing magic and mysticism of that time in favor of logic and deductive reasoning. As Egyptian civilization declined during the next millennium, the teachings of the Papyrus would be lost. It would not be until 300 B.C. when Hippocrates and his disciples in ancient Greece would once again revive logic in medical thinking and teaching. It is believed that the ancient Greeks had knowledge of the contents of the Edwin Smith Papyrus and its teachings and used them as the basis for their writings. As Europe entered the Dark Ages, so did medicine yet again, reverting to spells and prayers instead of judgment and reason. Although Hippocrates teachings were recognized by some scholars during the Middle Ages, they did not make up the basis for mainstream medical knowledge. With the dawn of the Renaissance, medicine would finally purge itself of its past supernatural foundation. Hippocratic teachings were used to form the basis of modern medicine, and medical pioneers in the 17 century studied the ancient Greek texts as the origin for their ideas. Many of the concepts physicians and patients today take as common knowledge originated in the Edwin Smith Papyrus. The authors attempt to uncover some of these

  1. Immunogenicity of HBV vaccine during stated shelf-life.

    PubMed

    Gloriani, Nina G; Srinivasa, Karthik; Bock, Hans L; Hoet, Bernard

    2010-07-01

    Thiomersal has been used as preservative in multi-dose vials of hepatitis B vaccine (Engerix-B). Due to safety concerns, thiomersal was replaced with 2-phenoxyethanol (2PE) as preservative in multi-dose vials. The potency of 2PE preserved hepatitis B vaccine multiple use vials was measured over the shelf-life in terms of immunogenicity, reactogenicity and safety. This single-blind, randomized study was conducted with the assistance of employees of GlaxoSmithKline Biologicals, makers of the Engerix-B vaccine. Four hundred twenty subjects aged > or =18 years were randomized to receive three doses (0, 1, 6 months) of 2PE preserved hepatitis B vaccine kept on the shelf <12 months (2PE New group), 2PE preserved hepatitis B vaccine kept on the shelf >18 months (2PE Old group), or thiomersal preserved hepatitis B vaccine [HBV(Thio) group]. Anti-HBs was measured by GlaxoSmithKline Biologicals post-vaccination; the reactogenicity and safety of the vaccines were assessed. Protective anti-HBs levels (> or =10 mIU/ml) were measured one month after dose 3. The results showed protective levels in 86.8% (2PE New), 89% (2PE Old) and 95.3% [HBV(Thio)]. There was no difference detected between the 2PE New and 2PE Old groups in terms of anti-HBs seroprotection rates and geometric mean concentrations one month after dose 3. However, both 2PE groups had significantly lower seroprotection rates than the HBV(Thio) group and the number of non-responders was higher in the 2PE groups than in the Thio group. A antibody response rates over time were similar between the 2PE New and Old groups. The reactogenicity profiles were acceptable and the ranges were similar for each group. The shelf-life of the vaccines had no impact on immunogenicity or reactogenicity and 2PE preserved hepatitis B vaccine can be considered stable over time.

  2. COLLISIONS BETWEEN DARK MATTER CONFINED HIGH VELOCITY CLOUDS AND MAGNETIZED GALACTIC DISKS: THE SMITH CLOUD

    SciTech Connect

    Galyardt, Jason; Shelton, Robin L. E-mail: rls@physast.uga.edu

    2016-01-01

    The Galaxy’s population of High Velocity Clouds (HVCs) may include a subpopulation that is confined by dark matter minihalos and falling toward the Galactic disk. We present the first magnetohydrodynamic simulational study of dark-matter-dominated HVCs colliding with a weakly magnetized galactic disk. Our HVCs have baryonic masses of 5 × 10{sup 6}M{sub ⊙} and dark matter minihalo masses of 0, 3 × 10{sup 8}, or 1 × 10{sup 9} M{sub ⊙}. They are modeled on the Smith Cloud, which is said to have collided with the disk 70 Myr ago. We find that, in all cases, the cloud’s collision with the galactic disk creates a hole in the disk, completely disperses the cloud, and forms a bubble-shaped structure on the far side of the disk. In contrast, when present, the dark matter minihalo continues unimpeded along its trajectory. Later, as the minihalo passes through the bubble structure and galactic halo, it accretes up to 6.0 × 10{sup 5} M{sub ⊙} in baryonic material, depending on the strengths of the magnetic field and minihalo gravity. These simulations suggest that if the Smith Cloud is associated with a dark matter minihalo and collided with the Galactic disk, the minihalo has accreted the observed gas. However, if the Smith Cloud is dark-matter-free, it is on its first approach toward the disk. These simulations also suggest that the dark matter is most concentrated either at the head of the cloud or near the cloud, depending upon the strength of the magnetic field, a point that could inform indirect dark matter searches.

  3. Smith Newton Vehicle Performance Evaluation – Gen 2 – Cumulative; Energy Efficiency & Renewable Energy (EERE)

    SciTech Connect

    2014-10-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  4. Smith Newton Vehicle Performance Evaluation – Cumulative; Vehicle Technologies Office (VTO), Energy Efficiency & Renewable Energy (EERE)

    SciTech Connect

    2013-10-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  5. Smith Newton Vehicle Performance Evaluation – 4th Quarter 2013; NREL (National Renewable Energy Laboratory)

    SciTech Connect

    2014-01-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  6. Smith Newton Vehicle Performance Evaluation - Gen2 - 1Q2014 (Brochure)

    SciTech Connect

    Not Available

    2014-04-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. U.S. companies participating in this evaluation project received funding from the American Recovery and Reinvestment Act to cover part of the cost of purchasing these vehicles. Through this project, Smith Electric Vehicles is building and deploying 500 all-electric medium-duty trucks that will be deployed by a variety of companies in diverse climates across the country.

  7. LIGHT SOURCE: Design of a new compact THz source based on Smith-Purcell radiation

    NASA Astrophysics Data System (ADS)

    Dai, Dong-Dong; Bei, Hua; Dai, Zhi-Min

    2009-06-01

    In recent years, people are dedicated to the research work of finding compact THz sources with high emission power. Smith-Purcell radiation is qualified for the possibility of coherent enhancement due to the effect of FEL mechanism. The compact experiment device is expected to produce hundreds mW level THz ray. The electron beam with good quality is provided under the optimized design of the electron gun. Besides, the grating is designed as an oscillator without any external feedbacks. While the beam passes through the grating surface, the beam bunching will be strong and the second harmonics enhancement will be evident, as is seen from the simulation results.

  8. STS-110 M.S. Smith driving M-113 personnel carrier during TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-110 Mission Specialist Steven Smith waits his turn at driving the M-113 armored personnel carrier, part of Terminal Countdown Demonstration Test activities. TCDT includes emergency egress training and a simulated launch countdown, and is held at KSC prior to each Space Shuttle flight. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  9. Mood disorder in a patient with Smith-Magenis syndrome: a case report.

    PubMed

    Bersani, Giuseppe; Russo, Daniele; Limpido, Lucilla; Marconi, Daniela

    2007-02-01

    Smith-Magenis syndrome (SMS) is a microdeletion syndrome characterized by physical and neurobehavioural features. This report describes the case of a 27 year old female affected by SMS associated with a diagnosis, according to DSMIV criteria, of Mood Disorder N.O.S. and Intermittent Explosive Disorder. To our knowledge, the association of SMS with mood shifts has never been reported. Considering the genetic alterations that characterizes the SMS, further investigations on the region of the chromosome 17p11.2 could help produce more information on the role of melatonin in the genesis of mood disorder.

  10. STS-110 M.S. Smith, Ross, and Walheim in Atlantis during TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- (Left to right) STS-110 Mission Specialists Steven Smith, Jerry Ross and Rex Walheim settle into their seats aboard Space Shuttle Atlantis prior to a simulated launch countdown. The simulation is part of Terminal Countdown Demonstration Test activities. TCDT also includes emergency egress training and is held at KSC prior to each Space Shuttle flight. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  11. STS-110 M.S. Ross and Smith in M-113 personnel carrier during TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- With STS-110 Mission Specialists Jerry Ross (far left) and Steven Smith (third from left) on board, Commander Michael Bloomfield scatters dust as he practices driving the M-113 armored personnel carrier. The driving is part of Terminal Countdown Demonstration Test activities, which include emergency egress training and a simulated launch countdown. The TCDT is held at KSC prior to each Space Shuttle flight. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  12. STS-110 M.S. Smith and Ross in slidewire basket during TCDT

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-110 Mission Specialists Steven L. Smith (left) and Jerry L. Ross (right) get ready to climb out of the slidewire basket, part of emergency egress equipment on the launch pad.. The crew is taking part in Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown, held at KSC prior to each Space Shuttle flight. Scheduled for launch April 4, the 11-day mission will feature Shuttle Atlantis docking with the International Space Station (ISS) and delivering the S0 truss, the centerpiece-segment of the primary truss structure that will eventually extend over 300 feet.

  13. Graphene on nanoscale gratings for the generation of terahertz Smith-Purcell radiation

    SciTech Connect

    Tantiwanichapan, Khwanchai; Wang, Xuanye; Swan, Anna K.; Paiella, Roberto

    2014-12-15

    Generation of THz radiation based on the Smith-Purcell effect in graphene is investigated numerically. The specific device geometry considered involves an electrically biased single-layer sheet of graphene deposited on a periodic array of holes in a solid substrate. Rigorous electrodynamic simulations combined with a basic model of charge transport are presented, showing that technologically significant output power levels can be obtained at geometrically tunable THz frequencies. These results suggest that graphene is a uniquely suited materials platform for the demonstration of THz electron-beam radiation mechanisms in compact solid-state systems.

  14. A new Smith predictor and controller for control of processes with long dead time.

    PubMed

    Kaya, Ibrahim

    2003-01-01

    Good control of processes with long dead time is often achieved using a Smith predictor configuration. Typically a PI or PID controller is used; however, it is shown in this paper that for some situations improved set point and disturbance responses can be obtained if a PI-PD controller is used. Several methods are possible for selecting the parameters of the PI-PD controller but when the plant transfer function has no zeros, the use of the standard forms provides a simple algebraic approach, and also reveals why difficulties may be encountered if a PID controller is used. Some examples are given to show the value of the approach presented.

  15. Concrete and relational vocabulary: comparison between Williams and Smith-Magenis syndromes.

    PubMed

    Garayzábal Heinze, Elena; Osório, Ana; Lens, María; Sampaio, Adriana

    2014-12-01

    We compared the performance of two clinical groups, Williams syndrome (WS) and Smith-Magenis syndrome (SMS), in terms of concrete and relational vocabulary. We analyzed (a) whether the WS group had an advantage in concrete vocabulary when compared to the SMS group, as good concrete vocabulary knowledge is considered a hallmark of WS; (b) if spatial processing difficulties in WS would be reflected specifically in their knowledge of relational spatial vocabulary; (c) if a specific vocabulary profile could be outlined for SMS. Our results show similar performances on receptive concrete and relational vocabulary in both groups. However, and as anticipated, performance on relational space concepts was significantly lower in the WS group.

  16. Generation of induced Smith-Purcell radiation: free-electron laser in open system

    NASA Astrophysics Data System (ADS)

    Klochkov, Dmitry N.; Oganesyan, Koryun B.; Ayryan, Edik A.; Izmailian, Nikolay Sh.

    2016-04-01

    We have used the framework of the dispersion equation to study coherent Smith-Purcell (SP) radiation induced by a relativistic magnetized electron beam in the absence of a resonator. As an important example of the application of the obtained results of our previous paper JMO v.57, 2060, (2010) the growth rate of SP FEL in the case with a rectangular grating was calculated. The growth rate of the instability is proportional to the square root of the electron beam current. The calculated results are consistent with the experimental data obtained by Urata et al. [Phys. Rev. Lett. 80, 516 (1998)].

  17. Enhance the terahertz Smith-Purcell superradiant radiation by using dielectric loaded grating

    NASA Astrophysics Data System (ADS)

    Cao, Miaomiao; Liu, Wenxin; Wang, Yong; Li, Ke

    2015-08-01

    A dielectric loaded grating (DLG) for terahertz Smith-Purcell (SP) device is proposed to enhance the radiation intensity. By using the theoretical analysis and particle-in-cell simulations, the dispersion characteristics and SP superradiant radiation are investigated. Compared with the general metal grating, the usage of DLG can improve the magnitude of electric field and, consequently, strengthen the interaction of the evanescent wave with electron beam, which can improve the growth rate, enhance the SP superradiant radiation, and lower the start current for the operation of SP free-electron laser.

  18. Basic repository source term and data sheet report: Deaf Smith County

    SciTech Connect

    Not Available

    1987-01-01

    This report is one of a series describing studies undertaken in support of the US Department of Energy Civilian Radioactive Waste Management (CRWM) Program. This study contains the derivation of values for environmental source terms and resources consumed for a CRWM repository. Estimates include heavy construction equipment; support equipment; shaft-sinking equipment; transportation equipment; and consumption of fuel, water, electricity, and natural gas. Data are presented for construction and operation at an assumed site in Deaf Smith County, Texas. 2 refs., 6 tabs.

  19. Hydrogeologic testing plan for Deep Hydronest Test Wells, Deaf Smith County site, Texas

    SciTech Connect

    Not Available

    1987-12-01

    This report discusses methods of hydraulic testing which are recommended for use in the Deep Hydronest Test Wells at the proposed high level nuclear waste repository site in Deaf Smith County, Texas. The deep hydronest wells are intended to provide geologic, geophysical and hydrologic information on the interval from the Upper San Andres Formation to the base of the Pennsylvanian system at the site. Following the period of drilling and testing, the wells will be converted into permanent monitoring installations through which fluid pressures and water quality can be monitored at various depths in the section. 19 refs., 17 figs., 2 tabs.

  20. Air pollutant emission rates for sources at the Deaf Smith County repository site

    SciTech Connect

    Not Available

    1985-11-01

    This document summarizes the air-quality source terms used for the Deaf Smith County, Texas environmental assessment report and explains their derivation. The engineering data supporting these source terms appear as appendixes to this report and include summary equipment lists for the repository and detailed equipment lists for the exploratory shaft. Although substantial work has been performed in establishing the current repository design, a greater effort will be required for the final design. Consequently, the repository emission rates presented here should be considered as preliminary estimates. Another set of air pollution emission rates will be calculated after design data are more firmly established. 18 refs., 15 tabs.

  1. Epilepsy and chromosomal rearrangements in Smith-Magenis Syndrome [del(17)(p11.2p11.2)].

    PubMed

    Goldman, Alica M; Potocki, Lorraine; Walz, Katherina; Lynch, Jennifer K; Glaze, Daniel G; Lupski, James R; Noebels, Jeffrey L

    2006-02-01

    Smith-Magenis syndrome is a multiple congenital anomalies/mental retardation syndrome associated with a heterozygous deletion of chromosome 17p11.2. Seizures have not been formally studied in this population. Our objectives were to estimate the prevalence of seizures and electroencephalographic (EEG) epileptiform abnormalities in patients with Smith-Magenis syndrome with defined chromosomal rearrangements and to describe the spectrum of abnormal EEG patterns. Prolonged video-EEGs were obtained in 60 patients. Eighteen percent of patients reported a seizure history; however, abnormal EEGs were identified in 31 of the 60 subjects and 27 of 31 were epileptiform. Generalized epileptiform patterns were the most common (73%). Most patients with either small or large deletions had an abnormal EEG (83%; 75%) in contrast to those with a common deletion (49%). Our results indicate that epileptiform EEG abnormalities are frequent in patients with Smith-Magenis syndrome. Considering that close to one third of individuals with Smith-Magenis syndrome with epileptiform abnormalities also had a history of clinical seizures, cortical hyperexcitability and epilepsy should be considered an important component of the Smith-Magenis syndrome clinical phenotype.

  2. The education and medical practice of Dr. James McCune Smith (1813-1865), first black American to hold a medical degree.

    PubMed Central

    Morgan, Thomas M.

    2003-01-01

    James McCune Smith (1813-1865)--first black American to obtain a medical degree, prominent abolitionist and suffragist, compassionate physician, prolific writer, and public intellectual--has been relatively neglected by historians of medicine. No biography of Smith exists to this day, though he has been the subject of several essays. Born, in his own words, "the son of a self-emancipated bond-woman," and denied admission to colleges in the United States, his native land, Smith earned medical, master's, and baccalaureate degrees at Glasgow University in Scotland. On his return to New York City in 1837, Smith became the first black physician to publish articles in US medical journals. Smith was broadly involved in the anti-slavery and suffrage movements, contributing to and editing abolitionist newspapers and serving as an officer of many organizations for the improvement of social conditions in the black community. In his scientific writings Smith debunked the racial theories in Thomas Jefferson's Notes on the State of Virginia, refuted phrenology and homeopathy, and responded with a forceful statistical critique to the racially biased US Census of 1840. Frederick Douglass, Gerrit Smith, and John Brown personally collaborated with James McCune Smith in the fight for black freedom. As the learned physician-scholar of the abolition movement, Smith was instrumental in making the overthrow of slavery credible and successful. Images Figure 1 PMID:12911258

  3. The education and medical practice of Dr. James McCune Smith (1813-1865), first black American to hold a medical degree.

    PubMed

    Morgan, Thomas M

    2003-07-01

    James McCune Smith (1813-1865)--first black American to obtain a medical degree, prominent abolitionist and suffragist, compassionate physician, prolific writer, and public intellectual--has been relatively neglected by historians of medicine. No biography of Smith exists to this day, though he has been the subject of several essays. Born, in his own words, "the son of a self-emancipated bond-woman," and denied admission to colleges in the United States, his native land, Smith earned medical, master's, and baccalaureate degrees at Glasgow University in Scotland. On his return to New York City in 1837, Smith became the first black physician to publish articles in US medical journals. Smith was broadly involved in the anti-slavery and suffrage movements, contributing to and editing abolitionist newspapers and serving as an officer of many organizations for the improvement of social conditions in the black community. In his scientific writings Smith debunked the racial theories in Thomas Jefferson's Notes on the State of Virginia, refuted phrenology and homeopathy, and responded with a forceful statistical critique to the racially biased US Census of 1840. Frederick Douglass, Gerrit Smith, and John Brown personally collaborated with James McCune Smith in the fight for black freedom. As the learned physician-scholar of the abolition movement, Smith was instrumental in making the overthrow of slavery credible and successful.

  4. Water-quality assessment of the Smith River drainage basin, California and Oregon

    USGS Publications Warehouse

    Iwatsubo, Rick T.; Washabaugh, Donna S.

    1982-01-01

    A water-quality assessment of the Smith River drainage basin was made to provide a summary of the water-quality conditions including known or potential water-quality problems. Results of the study showed that the water quality of the Smith River is excellent and generally meets the water-quality objectives for the beneficial uses identified by the California Regional Water Quality Control Board, North Coast Region. Known and potential problems related to water quality include: Sedimentation resulting from both natural erosional processes and land-use activities such as timber harvest, road construction, and mining that accelerate the erosional processes; bacterial contamination of surface and ground waters from inundated septic tanks and drainfields, and grazing activities; industrial spills which have resulted in fish kills and oil residues; high concetrations of iron in ground water; log and debris jams creating fish migration barriers; and pesticide and trace-element contamination from timber-harvest and mining activities, respectively. Future studies are needed to establish: (1) a sustained long-term monitoring program to provide a broad coverage of water-quality conditions in order to define long-term water-quality trends; and (2) interpretive studies to determine the source of known and potential water-quality problems. (USGS)

  5. Neurodevelopment of children under 3 years of age with Smith-Magenis syndrome.

    PubMed

    Wolters, Pamela L; Gropman, Andrea L; Martin, Staci C; Smith, Michaele R; Hildenbrand, Hanna L; Brewer, Carmen C; Smith, Ann C M

    2009-10-01

    Systematic data regarding early neurodevelopmental functioning in Smith-Magenis syndrome are limited. Eleven children with Smith-Magenis syndrome less than 3 years of age (mean, 19 months; range, 5-34 months) received prospective multidisciplinary assessments using standardized measures. The total sample scored in the moderately to severely delayed range in cognitive functioning, expressive language, and motor skills and exhibited generalized hypotonia, oral-motor abnormalities, and middle ear dysfunction. Socialization skills were average, and significantly higher than daily living, communication, and motor abilities, which were below average. Mean behavior ratings were in the nonautistic range. According to exploratory analyses, the toddler subgroup scored significantly lower than the infant subgroup in cognition, expressive language, and adaptive behavior, suggesting that the toddlers were more delayed than the infants relative to their respective peers. Infants aged approximately 1 year or younger exhibited cognitive, language, and motor skills that ranged from average to delayed, but with age-appropriate social skills and minimal maladaptive behaviors. At ages 2 to 3 years, the toddlers consistently exhibited cognitive, expressive language, adaptive behavior, and motor delays and mildly to moderately autistic behaviors. Combining age groups in studies may mask developmental and behavioral differences. Increased knowledge of these early neurodevelopmental characteristics should facilitate diagnosis and appropriate intervention.

  6. Wigner-Smith time delay and its application to attosecond streaking

    NASA Astrophysics Data System (ADS)

    Goldsmith, Cory; Su, Jing; Becker, Andreas; Jaron-Becker, Agnieszka

    2015-05-01

    Attosecond streaking experiments have been suggested as a means for observing temporal delays in photoemission, but the interpretation of the time delays observed in such experiments is still debated. Using a calculation of the streaking delays as a field-weighted sum over finite-range delays accumulated over the duration of the streaking pulse length, we provide further analysis into the role the Coulomb potential plays in the observed, so-called ``streaking delay.'' To this end, we make use of cut-off Coulomb and single active electron (SAE) potentials to calculate field-free Wigner-Smith-like time delays accumulated over small intervals of time to formulate an analytical model for the calculation of the streaking delays for hydrogenic atoms, as well as for SAE model potentials for noble gases. Our results indicate that in most cases, the influence of the streaking field on the short-range parts of the potential is a small effect. This allows for the representation of the streaking delay as the sum of the Wigner-Smith (WS) delay from scattering theory and the coupling between the streaking and Coulomb fields. We acknowledge the following support: C.G., J.S., and A.B: U.S. DOE, Division of Chemical Sciences, Atomic, Molecular and Optical Sciences Program (Award No. DE-FG02-09ER16103), A.J.-B.: U.S. NSF (Grants No. PHY-1125844 and No. PHY-1068706).

  7. The importance of using fluorescence in situ hybridization for the diagnosis of Smith-Magenis syndrome

    SciTech Connect

    Juyal, R.C.; Greenberg, F.; Lupski, J.R.

    1994-09-01

    Smith-Magenis syndrome (SMS) is a clinically recognizable multiple congenital anomaly/mental retardation syndrome associated with deletion of chromosome 17p11.2. Quality metaphase preparations are required for unambiguous detection of the deletion. We and others have reported cases of SMS due to mosaicism for del(17)(p11.2). Examination of peripheral blood lymphocyte cultures of a patient with the SMS phenotype at 850 band level of resolution revealed a low level mosaicism (11%) for the deletion. Examination of fibroblasts at relatively low resolution revealed the deletion in all cells. In a second study, we reported molecular evidence for mosaicism in the unaffected mother of an SMS patient who demonstrated mosaicism (55%) for the deletion at a resolution level of < 500 bands. We now report a different SMS patient who was initially diagnosed as mosaic del(17)(p11.2) in two different cytogenetic laboratories. A third blinded cytogenetic study yielded a questionable diagnosis. Fluorescence in situ hybridization (FISH) conducted in two different laboratories with two different markers shown to be within the deletion region and a control marker from chromosome 17 demonstrated a deletion in 20/20 and 25/25 metaphases scored, respectively. It appears the latter patient may harbor a very small deletion and that FISH is a more reliable test for the Smith-Magenis deletion. Furthermore, FISH should be used to confirm or refute mosaicism seen in routine cytogenetics studies.

  8. The Smith Cloud: A High-Velocity Cloud Colliding with the Milky Way

    NASA Astrophysics Data System (ADS)

    Lockman, Felix J.; Benjamin, Robert A.; Heroux, A. J.; Langston, Glen I.

    2008-05-01

    New 21 cm H I observations made with the Green Bank Telescope show that the high-velocity cloud known as the Smith Cloud has a striking cometary appearance and many indications of interaction with the Galactic interstellar medium. The velocities of interaction give a kinematic distance of 12.4 +/- 1.3 kpc, consistent with the distance derived from other methods. The Cloud is >3 × 1 kpc in size, and its tip at (l, b) ≈ 39°, -13° is 7.6 kpc from the Galactic center and 2.9 kpc below the Galactic plane. It has >106 M⊙ in H I. Its leading section has a total space velocity near 300 km s-1, is moving toward the Galactic plane with a velocity of 73 +/- 26 km s-1, and is shedding material to the Galaxy. In the absence of drag, the Cloud will cross the plane in about 27 Myr. The Smith Cloud may be an example of the accretion of gas by the Milky Way that is needed to explain certain persistant anomalies in Galactic chemical evolution.

  9. A New Take on John Maynard Smith's Concept of Protein Space for Understanding Molecular Evolution.

    PubMed

    Ogbunugafor, C Brandon; Hartl, Daniel L

    2016-10-01

    Much of the public lacks a proper understanding of Darwinian evolution, a problem that can be addressed with new learning and teaching approaches to be implemented both inside the classroom and in less formal settings. Few analogies have been as successful in communicating the basics of molecular evolution as John Maynard Smith's protein space analogy (1970), in which he compared protein evolution to the transition between the terms WORD and GENE, changing one letter at a time to yield a different, meaningful word (in his example, the preferred path was WORD → WORE → GORE → GONE → GENE). Using freely available computer science tools (Google Books Ngram Viewer), we offer an update to Maynard Smith's analogy and explain how it might be developed into an exploratory and pedagogical device for understanding the basics of molecular evolution and, more specifically, the adaptive landscape concept. We explain how the device works through several examples and provide resources that might facilitate its use in multiple settings, ranging from public engagement activities to formal instruction in evolution, population genetics, and computational biology.

  10. GPU-based cloud service for Smith-Waterman algorithm using frequency distance filtration scheme.

    PubMed

    Lee, Sheng-Ta; Lin, Chun-Yuan; Hung, Che Lun

    2013-01-01

    As the conventional means of analyzing the similarity between a query sequence and database sequences, the Smith-Waterman algorithm is feasible for a database search owing to its high sensitivity. However, this algorithm is still quite time consuming. CUDA programming can improve computations efficiently by using the computational power of massive computing hardware as graphics processing units (GPUs). This work presents a novel Smith-Waterman algorithm with a frequency-based filtration method on GPUs rather than merely accelerating the comparisons yet expending computational resources to handle such unnecessary comparisons. A user friendly interface is also designed for potential cloud server applications with GPUs. Additionally, two data sets, H1N1 protein sequences (query sequence set) and human protein database (database set), are selected, followed by a comparison of CUDA-SW and CUDA-SW with the filtration method, referred to herein as CUDA-SWf. Experimental results indicate that reducing unnecessary sequence alignments can improve the computational time by up to 41%. Importantly, by using CUDA-SWf as a cloud service, this application can be accessed from any computing environment of a device with an Internet connection without time constraints.

  11. Design and implementation of a hybrid MPI-CUDA model for the Smith-Waterman algorithm.

    PubMed

    Khaled, Heba; Faheem, Hossam El Deen Mostafa; El Gohary, Rania

    2015-01-01

    This paper provides a novel hybrid model for solving the multiple pair-wise sequence alignment problem combining message passing interface and CUDA, the parallel computing platform and programming model invented by NVIDIA. The proposed model targets homogeneous cluster nodes equipped with similar Graphical Processing Unit (GPU) cards. The model consists of the Master Node Dispatcher (MND) and the Worker GPU Nodes (WGN). The MND distributes the workload among the cluster working nodes and then aggregates the results. The WGN performs the multiple pair-wise sequence alignments using the Smith-Waterman algorithm. We also propose a modified implementation to the Smith-Waterman algorithm based on computing the alignment matrices row-wise. The experimental results demonstrate a considerable reduction in the running time by increasing the number of the working GPU nodes. The proposed model achieved a performance of about 12 Giga cell updates per second when we tested against the SWISS-PROT protein knowledge base running on four nodes.

  12. A generalization of the Drude-Smith formula for magneto-optical conductivities in Faraday geometry

    NASA Astrophysics Data System (ADS)

    Han, F. W.; Xu, W.; Li, L. L.; Zhang, C.

    2016-06-01

    In this study, we generalize the impulse response approach and Poisson statistics proposed by Smith [Phys. Rev. B 64, 155106 (2001)] to evaluate the longitudinal and transverse magneto-optical conductivities in an electron gas system in Faraday geometry. Comparing with the standard Drude model, the coefficients an are introduced in the Drude-Smith formula to describe the backscattering or localization effect for the nth electronic scattering event. Such a formula can also be applied to study the elements of the dielectric function matrix in the presence of magnetic and radiation fields in electron gas systems. This theoretical work is primely motivated by recent experimental activities in measuring the real and imaginary parts of longitudinal and transverse magneto-optical conductivities in condensed matter materials and electronic devices using terahertz time-domain spectroscopy. We believe that the results obtained from this study can provide an appropriate theoretical tool in reproducing the experimental findings and in fitting with experimental data to determine the important sample and material parameters.

  13. Site study plan for borehole search and characterization, Deaf Smith County Site, Texas: Revision 1

    SciTech Connect

    Not Available

    1987-12-22

    This site study plan describes the Borehole Search and Characterization field activities to be conducted during the early stages of Site Characterization at the Deaf Smith County site, Texas. The field program has been designed to provide data useful in addressing information/data needs resulting from Federal/State/Local regulatory requirements and repository program requirements. Air and ground surveys, an extensive literature search, and landowner interviews will be conducted to locate wells within and adjacent to the proposed nuclear waste repository site in Deaf Smith County. Initially, the study will center around the planned Exploratory Shaft Facilities location and will expand outward from that location. Findings from this study may lead to preparation of a new site study plan to search suspected borehole locations, and excavate or reenter known boreholes for additional characterization or remedial action. The Salt Repository Project (SRP) Networks specify the schedule under which the program will operate. The Technical Field Services Contractor (TFSC) is responsible for conducting the field program. Data will be handled and reported in accordance with established SRP procedures. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that appropriate documentation is maintained. 13 refs., 6 figs., 3 tabs.

  14. Smith-Magenis syndrome and its circadian influence on development, behavior, and obesity - own experience.

    PubMed

    Chen, Li; Mullegama, Sureni V; Alaimo, Joseph T; Elsea, Sarah H

    2015-01-01

    Smith-Magenis syndrome (SMS) is a complex genetic disorder characterized by sleep disturbance, multiple developmental anomalies, psychiatric behavior, and obesity. It is caused by a heterozygous 17p11.2 microdeletion containing the retinoic acid-induced 1 (RAI1) gene or mutation within RAI1. Sleep disorder is one of the most penetrant features of SMS. Molecular genetic studies indicate that RAI1 regulates circadian rhythm genes and when haploinsucient, causes a distorted molecular circadian network that may be the cause of the sleep disturbance and the inverted rhythm of melatonin present in most individuals with SMS. RAI1 also regulates genes involved in development, neurobehavior, and lipid metabolism. Sleep debt, daytime melatonin secretion, and environmental stress often contribute to negative behavior in persons with SMS, and food entrained circadian rhythm also influences food intake behavior and humoral signals, which also affect development and neurobehavior. The cross-talk between circadian rhythm, development, metabolism and behaviors affect the multiple phenotypic outcomes in Smith-Magenis syndrome. These findings shed light on possible effective and personalized drug treatments for SMS patients in the future.

  15. Speeding-up Bioinformatics Algorithms with Heterogeneous Architectures: Highly Heterogeneous Smith-Waterman (HHeterSW).

    PubMed

    Gálvez, Sergio; Ferusic, Adis; Esteban, Francisco J; Hernández, Pilar; Caballero, Juan A; Dorado, Gabriel

    2016-10-01

    The Smith-Waterman algorithm has a great sensitivity when used for biological sequence-database searches, but at the expense of high computing-power requirements. To overcome this problem, there are implementations in literature that exploit the different hardware-architectures available in a standard PC, such as GPU, CPU, and coprocessors. We introduce an application that splits the original database-search problem into smaller parts, resolves each of them by executing the most efficient implementations of the Smith-Waterman algorithms in different hardware architectures, and finally unifies the generated results. Using non-overlapping hardware allows simultaneous execution, and up to 2.58-fold performance gain, when compared with any other algorithm to search sequence databases. Even the performance of the popular BLAST heuristic is exceeded in 78% of the tests. The application has been tested with standard hardware: Intel i7-4820K CPU, Intel Xeon Phi 31S1P coprocessors, and nVidia GeForce GTX 960 graphics cards. An important increase in performance has been obtained in a wide range of situations, effectively exploiting the available hardware.

  16. Birth of the first ESS: George Price, John Maynard Smith, and the discovery of the lost "Antlers" paper.

    PubMed

    Harman, Oren

    2011-01-15

    The application of game theory to evolutionary problems is so commonplace today, that few stop to consider how it all began. John Maynard Smith and George R. Price's 1973 Nature article, "The Logic of Animal Conflict," is often referred to as the first description in the literature of the concept of an evolutionary stable strategy (ESS), but what was the "behind the scenes" of the writing of that seminal paper? This article tracks the little known story of the curious American polymath, George Price. As will be shown, it was an earlier paper, the lost "Antlers, Intraspecific Combat, and Altruism," sent by Price to Nature in August 1968 (Unpublished), and refereed by Maynard Smith, which instigated the birth of the first ESS. Recently, the "Antlers" paper has been re-discovered by the author, shedding new light, together with letters and journals from the personal papers of George Price and John Maynard Smith, on their historical paper.

  17. Smith-Magenis Syndrome and Social Security Administration's Compassionate Allowances Initiative: An Evaluative Review of the Literature.

    PubMed

    Burke, Shanna L; Maramaldi, Peter

    2016-08-01

    The Social Security Administration (SSA) launched the Compassionate Allowances List (CAL) in 2008. This created a mechanism for expediting review and delivery of disability benefits, while decreasing application backlog. This study hypothesized that developmental disorders, such as Smith-Magenis syndrome, may meet criterion for inclusion. An evaluative review of the literature was undertaken to determine if the expedited review criterion was met. Ten databases were searched and articles meeting pre-defined criteria were coded according to the SSA definition of disability to determine if severity indices screen in or screen out certain severity levels or exclude Smith-Magenis syndrome entirely in relation to the CAL program. It was strongly recommended that Smith-Magenis syndrome receive consideration for inclusion in the CAL.

  18. Birth of the Canadian Digestive Health Foundation.

    PubMed

    Beck, Ivan T

    2004-01-01

    The Canadian Digestive Disease Foundation, renamed the Canadian Digestive Health Foundation--Fondation canadienne pour la promotion de la santé digestive--in December 2001, is the culmination of ongoing efforts by the Canadian Association of Gastroenterology to establish an independent charitable organization. In February 2001, it was officially endorsed as the Foundation for the Canadian Association of Gastroenterology. The initial efforts to establish this Foundation, led by Dr Richard McKenna in 1963, were unsuccessful. In 1991, Glaxo Canada (now GlaxoSmithKline) became a founding donor, and with the four founding physicians--Drs Ivan T Beck, Richard H Hunt, Suzanne E Lemire and Alan BR Thomson--the expenses to establish the Foundation were met. A charitable number was obtained in 1995 (0997427-11). The second founding donor was Janssen Canada (now Janssen-Ortho), and public education support came from Astra Canada (now AstraZeneca Canada). The Foundation initially relied on corporate donors, but now approaches physicians, patients and the general public. The objectives of the Foundation are to advance the science of gastroenterology and to provide knowledge of digestive diseases and nutrition to the general public, to enhance the quality of life of persons who are afflicted with these disorders. The major achievements of the Foundation are the provision of one-year operating grants to new investigators, which have allowed them to accumulate early data and subsequently obtain support from other major granting organizations. It also provides Fellowships and studentship support grants, in conjunction with the Canadian Institutes of Health Research and the pharmaceutical industry. The education committee found that there was little research support in this field, considering the large economic burden of digestive disease and the amount of outstanding work done by Canadian researchers. A bilingual Web site, a web-based specialist's discussion program and bilingual

  19. The Giant Resin Bee, Megachile sculpturalis Smith: New Distributional Records for the Mid- and Gulf-south USA

    PubMed Central

    Tripodi, Amber D.; Sampson, Blair J.

    2015-01-01

    Abstract Background Megachile (Callomegachile) sculpturalis Smith, the giant resin bee, is an adventive species in the United States. First established in the United States during the early 1990s, records currently exist from most states east of the Mississippi River along with Iowa and Kansas. New information New distributional records are presented for Megachile (Callomegachile) sculpturalis Smith, an introduced bee. Additional records presented here expand the known distribution southwest through Arkansas, Louisiana, Mississippi, Missouri, and Texas. An updated host plant list containing new records is also presented, expanding the number of known floral associations. PMID:26696766

  20. Prenatal diagnosis of interstitial deletion of 17(p11.2p11.2) (Smith-Magenis Syndrome)

    SciTech Connect

    1994-01-15

    Interstitial deletion of 17p11.2 is associated with Smith-Magenis syndrome. This is a recognizable chromosomal deletion syndrome, characterized by brachycephaly, midface hypoplasia, growth and mental retardation, behavioral problems, and ocular abnormalities. Molecular analysis indicates it is a contiguous gene syndrome. Over 50 patients have been reported since the deletion was first described by Smith et al. [1982]. Cases include one with mosaicism and a familial example. None were prenatally diagnosed. The authors report on the prenatal detection of interstitial deletion of 17p11.2. 11 refs., 1 fig.

  1. 36th Annual David W. Smith Workshop on Malformations and Morphogenesis: Abstracts of the 2015 annual meeting.

    PubMed

    Gripp, Karen W; Adam, Margaret P; Hudgins, Louanne; Carey, John C

    2016-07-01

    The 36th Annual David W Smith Workshop on Malformations and Morphogenesis was held on August 14-19, 2015 at the Harbourtowne Conference Center in St. Michaels Maryland. The Workshop, which honors the legacy of David W Smith, brought together over 120 clinicians and researchers interested in congenital malformations and their underlying mechanisms of morphogenesis. As is the tradition of the meeting, the Workshop highlighted five themes besides mechanisms of morphogenesis: Rasopathies, Eye Malformations, Therapeutics, Prenatal Diagnosis, and Disorders of Sex Development. This Conference Report includes the abstracts presented at the 2015 Workshop. © 2016 Wiley Periodicals, Inc.

  2. 35(th) Annual David W Smith Workshop on Malformations and Morphogenesis: abstracts of the 2014 annual meeting.

    PubMed

    Braddock, Stephen R; Lipinski, Robert J; Williams, Marc S; Carey, John C

    2015-08-01

    The 35(th) Annual David W Smith Workshop on Malformations and Morphogenesis was held on July 25-30, 2014 at the University of Wisconsin, Madison, Wisconsin. The conference, which honors the legacy of David Smith, brought together over 130 clinicians and researchers interested in congenital malformations and their underlying mechanisms of morphogenesis. As is the tradition of the meeting, the Workshop highlighted five themes besides mechanisms of morphogenesis: Evolution and Development, Minor Malformations, CHARGE syndrome, Craniofacial Development/ Malformations, and Disorders of Chromatin Remodeling. This Conference Report includes the abstracts presented at the Workshop.

  3. Drainage Area-Dependent Knickpoint Generation Mechanisms, Smith River, northern California

    NASA Astrophysics Data System (ADS)

    Caldwell, D. J.; Kelsey, H. M.

    2011-12-01

    Knickpoints and knickzones (reaches of relatively high gradient located immediately downstream of a knickpoint) are a prominent characteristic of the channel slopes of both mainstem and tributary channels of the 1,575 km2 Smith River drainage in northern California. We have investigated these knickpoints using aerial photos, 10 m and 1 m digital elevation models (DEM's), and NAIP images supplemented by Schmidt hammer rock strength measurements and field verification of channel and terrace elevations using real time kinematic GPS surveys. Two types of knickpoints occur. At higher drainage areas (threshold of greater than ~250 km2), knickpoints occur within rock types with no significant difference in rock strength. There is a distinct upstream convergence of the modern channel with the lowest elevated strath surface along these knickzones, resulting in elevated strath surfaces downstream of the knickzones. We infer that the knickpoints are transient and that the straths are more vertically separated from the modern channel only after the knickpoint has migrated upstream. The causative baselevel fall that generates migrating knickpoints in the Smith River may be eustatic sea level fall following Quaternary highstands. For instance, fluvial terraces are cut into stage 5 marine terraces at the coast and these fluvial terraces likely are generated in the wake of knickpoints migrating upstream. In contrast, at drainage areas less than ~250 km2, the only knickpoints present in channels are those associated with large landslides that mobilize entire hillslopes into the channel, forcing a channel response. Notably absent along the Smith River are any knickpoints associated with changes in rock strength, as measured by Schmidt hammer values. From these observations, we infer that, first, major knickpoints along channels above a threshold drainage area of about 250 km2 are generated by baselevel fall that propagates upstream through channels of varying rock type; and second

  4. Truman Smith's Reports on Nazi Militarism: Domestic Political Priorities and U.S. Foreign Policy-Making in Franklin Roosevelt's First and Second Terms

    ERIC Educational Resources Information Center

    Shearer, Sam

    2015-01-01

    After an accomplished military career leading up to and during World War II, Truman Smith (1893-1970) was seemingly forgotten. His name was seldom mentioned after the war until his memoirs were published posthumously in 1984. History shows Smith to be an astoundingly successful figure in military intelligence. This article provides a biography on…

  5. The Basis of James W. Fowler's Understanding of Faith in the Research of Wilfred Cantwell Smith: An Examination from an Evangelical Perspective

    ERIC Educational Resources Information Center

    Jones, Timothy Paul

    2004-01-01

    This article focuses on the influence of Wilfred Cantwell Smith's presentation of the nature of faith on James W. Fowler's faith-development paradigm. Smith contended that, in the pre-modern era, terms translated by the English words "faith" and "believe" denoted a personal allegiance that did not require assent to any objective assertions. Two…

  6. Kline DeWire Public Safety Officers' Retroactive Benefits Act

    THOMAS, 113th Congress

    Rep. Marino, Tom [R-PA-10

    2014-04-29

    07/21/2014 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. Monochromaticity of coherent Smith-Purcell radiation from finite size grating

    NASA Astrophysics Data System (ADS)

    Aryshev, A.; Potylitsyn, A.; Naumenko, G.; Shevelev, M.; Lekomtsev, K.; Sukhikh, L.; Karataev, P.; Honda, Y.; Terunuma, N.; Urakawa, J.

    2017-02-01

    Investigation of coherent Smith-Purcell radiation (SPR) spectral characteristics was performed both experimentally and by numerical simulation. The measurement of SPR spectral line shapes of different diffraction orders was carried out at the KEK LUCX facility. A pair of room-temperature Schottky barrier diode (SBD) detectors with sensitivity bands of 60-90 GHz and 320-460 GHz was used in the measurements. Reasonable agreement of experimental results and simulations performed with CST Studio Suite justifies the use of different narrow-band SBD detectors to investigate different SPR diffraction orders. It was shown that monochromaticity of the SPR spectral lines increases with diffraction order. The comparison of coherent transition radiation and coherent SPR intensities in sub-THz frequency range showed that the brightnesses of both radiation mechanisms were comparable. A fine tuning feasibility of the SPR spectral lines is discussed.

  8. Enhancement of Coherent THz Smith-Purcell Radiation by Resonance Overlapping

    NASA Astrophysics Data System (ADS)

    Li, Weiwei; Xu, Yuanfang; Lu, Yalin; He, Zhigang; Jia, Qika; Wang, Lin

    2017-01-01

    Frequency-locked coherent Smith-Purcell Radiation (SPR) is emitted when a train of pre-bunched electron beam passes close to the surface of a metallic grating, which develops an energy density spectrum restricted to harmonics of the bunching frequency. For the lamellar grating with narrow grooves, the radiation spectrum from a single electron can also have a feature of narrow band, which is related to the grating structure and the beam energy. The combination of them is proposed in this paper. By properly choosing the parameters, the peak frequency of single electron radiation can be overlapped with the harmonics of the bunching frequency of the electron bunch train, leading to the generation of extremely intense narrow-band THz radiation.

  9. Analysis of the sensory profile in children with Smith-Magenis syndrome.

    PubMed

    Hildenbrand, Hanna L; Smith, Ann C M

    2012-02-01

    This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and quadrants (p < .001). No main effects of age or gender were found, but an interaction effect of age by gender was found in Modulation of Sensory Input Affecting Emotional Responses, in which older females presented with the lowest scores. A significant decline over time was found in the Seeking pattern, reflecting increased vulnerability (p < .05). Nonsignificant trends suggest more vulnerabilities for older versus younger children, especially older females. The neurobehavioral phenotype in children with SMS is expanded by this description of sensory processing. How children with SMS experience and respond to everyday sensations informs multidisciplinary team decisions.

  10. Spectrally and Spatially Resolved Smith-Purcell Radiation in Plasmonic Crystals with Short-Range Disorder

    NASA Astrophysics Data System (ADS)

    Kaminer, I.; Kooi, S. E.; Shiloh, R.; Zhen, B.; Shen, Y.; López, J. J.; Remez, R.; Skirlo, S. A.; Yang, Y.; Joannopoulos, J. D.; Arie, A.; Soljačić, M.

    2017-01-01

    Electrons interacting with plasmonic structures can give rise to resonant excitations in localized plasmonic cavities and to collective excitations in periodic structures. We investigate the presence of resonant features and disorder in the conventional Smith-Purcell effect (electrons interacting with periodic structures) and observe the simultaneous excitation of both the plasmonic resonances and the collective excitations. For this purpose, we introduce a new scanning-electron-microscope-based setup that allows us to probe and directly image new features of electron-photon interactions in nanophotonic structures like plasmonic crystals with strong disorder. Our work creates new possibilities for probing nanostructures with free electrons, with potential applications that include tunable sources of short-wavelength radiation and plasmonic-based particle accelerators.

  11. Expression of gamma-hemolysin regulated by sae in Staphylococcus aureus strain Smith 5R.

    PubMed

    Yamazaki, Kazuko; Kato, Fuminori; Kamio, Yoshiyuki; Kaneko, Jun

    2006-06-01

    Staphylococcus aureus strain Smith 5R produces a two-component pore-forming toxin and forms a rough-surfaced colony with hemolytic haloes on human red blood cell plates (R[+]). Serial subcultures of the strain in broth caused the appearance of gamma-hemolysin negative variants with a smooth colony shape (S[-]), and the S[-] valiant became predominant in culture. The R[+] strain, in which agrA is naturally disrupted by an insertion of IS1181, produced high levels of gamma-hemolysin. In the S[-] variant, expression of both hlg and lukS-F mRNAs was strongly reduced. Nucleotide sequencing of the sae locus revealed that all isolated S[-] variants had spontaneous mutations in the sae locus. Recovery of gamma-hemolysin productivity in S[-] by transformation of the wild-type sae allele strongly suggested that the expression of gamma-hemolysin is positively regulated by sae in an agr-independent manner.

  12. Uranium hydrogeochemical and stream sediment reconnaissance of the Philip Smith Mountains NTMS quadrangle, Alaska

    SciTech Connect

    Not Available

    1981-09-01

    Results of a hydrogeochemical and stream sediment reconnaissance of the Philip Smith Mountains NTMS quadrangle, Alaska are presented. In addition to this abbreviated data release, more complete data are available to the public in machine-readable form. In this data release are location data, field analyses, and laboratory analyses of several different sample media. For the sake of brevity, many field site observations have not been included in this volume. These data are, however, available on the magnetic tape. Appendices A and B describe the sample media and summarize the analytical results for each medium. The data were subsetted by one of the Los Alamos National Laboratory (LANL) sorting programs into groups of stream sediment and lake sediment samples. For each group which contains a sufficient number of observations, statistical tables, tables of raw data, and 1:1000000 scale maps of pertinent elements have been included in this report.

  13. Adaptive and maladaptive behavior in children with Smith-Magenis Syndrome.

    PubMed

    Martin, Staci C; Wolters, Pamela L; Smith, Ann C M

    2006-05-01

    Children with Smith-Magenis Syndrome (SMS) exhibit deficits in adaptive behavior but systematic studies using objective measures are lacking. This descriptive study assessed adaptive functioning in 19 children with SMS using the Vineland Adaptive Behavior Scales (VABS). Maladaptive behavior was examined through parent questionnaires and the Childhood Autism Rating Scale. Cognitive functioning was evaluated with an age-appropriate test. Children scored below average on VABS Communication, Daily Living Skills, and Socialization scales. Learning problems and hyperactivity scales on the Conner's Parent Rating Scale were elevated, and girls were more impulsive than boys. Stereotypic and self-injurious behaviors were present in all children. Cognitive functioning was delayed and consistent with communication and daily living skills, while socialization scores were higher than IQ.

  14. Circadian rhythm disorder in a rare disease: Smith-Magenis syndrome.

    PubMed

    De Leersnyder, Hélène; Claustrat, Bruno; Munnich, Arnold; Verloes, Alain

    2006-06-27

    Smith-Magenis syndrome (SMS) is a clinically recognizable contiguous gene syndrome, caused by interstitial deletion of chromosome 17p11.2. The SMS phenotype include distinctive facial features, developmental delay and neurobehavioral abnormalities. The patients present major sleep disturbances ascribed to a phase shift of their circadian rhythm of melatonin with a paradoxical diurnal secretion of the hormone. Treatment with morning beta-blockers and evening melatonin reinstated a normally timed melatonin circadian rhythm, improved daytime behavior and restored normal sleep habits, resulting in a greatly improved quality of life for both SMS patients and their family. SMS is the demonstration of biological basis for sleep disorder in a genetic disease. Considering that clock genes mediate generation of circadian rhythms, we suggest that haploinsufficiency for a circadian system gene mapping to chromosome 17p11.2 may cause the inversion of circadian rhythm in SMS.

  15. Taxonomic studies on the ant genus Cerapachys Smith (Hymenoptera, Formicidae) from India

    PubMed Central

    Bharti, Himender; Akbar, Shahid Ali

    2013-01-01

    Abstract The Indianspeciesof the ant genus Cerapachys Smith are keyed. Twelve species are recognized of which 6 are described as new. The species are: Cerapachys aitkenii Forel, Cerapachys alii sp. n., Cerapachys anokha sp. n., Cerapachys besucheti Brown, Cerapachys biroi Forel, Cerapachys indicus Brown, Cerapachys longitarsus (Mayr), Cerapachys nayana sp. n., Cerapachys schoedli sp. n., Cerapachys seema sp. n., Cerapachys sulcinodis Emery and Cerapachys wighti sp. n. Geographic distribution and group affinities of the new species are discussed. A revised key to the Indian species is provided. The rare ergatoid queens of Cerapachys nayana, Cerapachys schoedli and Cerapachys seema are reported. Formed in response to selective pressures these ergatoid queens have a significant role in dispersal strategies and contribute much to our understanding of the biology of these ants. PMID:24146574

  16. Adam Smith's invisible hand is unstable: physics and dynamics reasoning applied to economic theorizing

    NASA Astrophysics Data System (ADS)

    McCauley, Joseph L.

    2002-11-01

    Neo-classical economic theory is based on the postulated, nonempiric notion of utility. Neo-classical economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics, however, a utility function generally does not exist mathematically due to nonintegrability. Price as a function of demand does not exist and all equilibria are unstable. Qualitatively, and empirically, the neo-classical prediction of price as a function of demand describes neither consumer nor trader demand. We also discuss five inconsistent definitions of equilibrium used in economics and finance, only one of which is correct, and then explain the fallacy in the economists’ notion of ‘temporary price equilibria’.

  17. Hydrologic data for an investigation of the Smith River Watershed through water year 2010

    USGS Publications Warehouse

    Nilges, Hannah L.; Caldwell, Rodney R.

    2012-01-01

    Hydrologic data collected through water year 2010 and compiled as part of a U.S. Geological Survey study of the water resources of the Smith River watershed in west-central Montana are presented in this report. Tabulated data presented in this report were collected at 173 wells and 65 surface-water sites. Figures include location maps of data-collection sites and hydrographs of streamflow. Digital data files used to construct the figures, hydrographs, and data tables are included in the report. Data collected by the USGS are also stored in the USGS National Water Information System database and are available through the USGS National Water Information System Water Data for Montana Web page at http://waterdata.usgs.gov/mt/nwis/.

  18. Differences in Social Motivation in Children with Smith-Magenis Syndrome and Down Syndrome.

    PubMed

    Wilde, Lucy; Mitchell, Anna; Oliver, Chris

    2016-06-01

    Social excesses, characterised by heightened social motivation, are important for describing social functioning. Smith-Magenis syndrome (SMS) is a potential exemplar of a disorder where heightened social motivation is associated with negative behavioural outcomes. In Down syndrome (DS) strong social motivation is described, but less commonly associated with behavioural problems. Children with SMS (n = 21) and DS (n = 19) were observed during social situations, in which familiarity of adults present and level of attention available were manipulated. Motivation in SMS was characterised by comparatively frequent social initiations when adult attention was low, and stronger preference for familiar adults, compared to DS. Findings provide insight into the nature of social motivation in SMS and support an argument for nuanced consideration of motivation.

  19. A few laced genes: women's standpoint in the feminist ancestry of Dorothy E. Smith.

    PubMed

    Smythe, Deirdre

    2009-04-01

    This article looks at the feminist activism of particular women in the ancestry of the eminent Canadian sociologist, Dorothy E. Smith, and at the archival data that confirm the traces of their influence found in her theory-building. Using the method of interpretative historical sociology and a conceptual framework drawn from Marx called the "productive forces," the article examines the feminist theology of her Quaker ancestor, Margaret Fell, and the militant suffrage activism of her mother and her grandmother, Dorothy Foster Place and Lucy Ellison Abraham, respectively. The article argues that the household labour of the remarkable women in her family line became a "productive force" that facilitated her imagining of the feminist theory, "the standpoint of women".

  20. Gender, professionalization, and the child in the Progressive Era: Patty Smith Hill, 1868-1946.

    PubMed

    Allen, Ann Taylor

    2011-01-01

    This article discusses the career of Patty Smith Hill, a major figure in the American kindergarten movement, in the context of the Progressive Era in American history. Hill, an educator and child-welfare activist, became known both as a reformer of early-childhood education and as an advocate of the inclusion of the kindergarten, originally a private institution, in public-school systems. The article acknowledges this as one of the most significant achievements of the woman-led reform movements of the Progressive Era, but at the same time notes that it involved a substantial transfer of power from the women who had originally developed the kindergarten to the male principals and superintendants who now supervised kindergarten teachers, often without much understanding of their distinctive methods and aims. As a professor at Columbia Teachers College, Hill also exercised an international influence. Hill's career exemplifies broader patterns of women's professionalization during the late-nineteenth and early-twentieth centuries.

  1. A multimode terahertz-Orotron with the special Smith-Purcell radiation

    NASA Astrophysics Data System (ADS)

    Liu, Weihao; Lu, Yalin; Wang, Lin; Jia, Qika

    2016-05-01

    We proposed and investigated a terahertz Orotron, which is based on the recently revealed special Smith-Purcell radiation. It overcomes the main obstacles of the traditional Orotron in the terahertz region—unreachable high starting-current-density and low radiation power. With the experimentally available electron beam and facilities, its average output power can reach hundreds of milliwatts and even several watts in terahertz region, which is many orders of magnitude higher than that of the traditional Orotron. Additionally, it can be controlled to operate in ether the first or the second order mode, and the radiation frequency can extend from 0.1 THz to 1 THz. These remarkable advantages make it a promising terahertz source for practical applications.

  2. Treatment of Smith-Lemli-Opitz Syndrome and Other Sterol Disorders

    PubMed Central

    Svoboda, Melissa D.; Christie, Jill M.; Eroglu, Yasemen; Freeman, Kurt A.; Steiner, Robert D.

    2013-01-01

    Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive genetic condition with a broad phenotype that results from deficiency of the final enzyme of the cholesterol synthesis pathway. This defect causes low or low-normal plasma cholesterol levels and increased 7- and 8-dehydrocholesterol (DHC) levels. Many therapies for SLOS and other disorders of sterol metabolism have been proposed, and a few of them have been undertaken in selected patients, but robust prospective clinical trials with validated outcome measures are lacking. We review the current literature and expert opinion on treatments for SLOS and other selected sterol disorders, including dietary cholesterol therapy, statin treatment, bile acid supplementation, medical therapies and surgical interventions, as well as directions for future therapies and treatment research. PMID:23042642

  3. STS-103 MS Smith prepares to enter orbiter from White Room

    NASA Technical Reports Server (NTRS)

    1999-01-01

    STS-103 Mission Specialist Steven L. Smith, in his orange launch and entry suit, waits for assistance from closeout crew members in the White Room before entering the orbiter. From left, they are NASA Quality Assurance Specialist Danny Wyatt, United Space Alliance (USA) Mechanical Technician Vinny Defranzo and USA Orbiter Vehicle Closeout Chief Travis Thompson. The White Room is an environmental chamber at the end of the orbiter access arm on the fixed service structure. It provides entry to the orbiter crew compartment. The mission, to service the Hubble Space Telescope, is scheduled to lift off at 7:50 p.m. EST Dec. 19 on mission STS-103, servicing the Hubble Space Telescope. Objectives for the nearly eight-day mission include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. Discovery is expected to land at KSC Monday, Dec. 27, at about 5:24 p.m. EST.

  4. Electron Bunch Profile Diagnostics in the Few FS Regime Using Coherent Smith-Purcell Radiation

    SciTech Connect

    Bartolini, R.; Clarke, C.; Delerue, N.; Doucas, G.; Pattle, K.; Perry, C.; Reichold, A.; Tovey, R.; /Oxford U.

    2011-12-13

    The rapid developments in the field of laser-driven particle acceleration hold the prospect of intense, highly relativistic electron bunches that are only a few fs long. The determination of the temporal profile of such bunches presents new challenges. The use of a radiative process such as Smith-Purcell radiation (SPR), is particularly promising in this respect. In this technique the beam is made to radiate a small amount of e/m radiation and the temporal profile is reconstructed from the measured spectral distribution of the radiation. We summarise the advantages of SPR and present the design parameters and preliminary results of the experiments at the FACET facility at SLAC. We also discuss a new approach to the problem of the recovery of the 'missing phase', which is essential for the accurate reconstruction of the temporal bunch profile.

  5. Ground-water conditions in the Triassic aquifer in Deaf Smith and Swisher Counties

    SciTech Connect

    Duffin, G.L.

    1984-12-01

    In April 1984, the Director of the Nuclear Waste Programs of the Governor's Office requested a study be undertaken by the Texas Department of Water Resources on the ground-water conditions in the Triassic aquifer in Deaf Smith and Swisher Counties. The need for the study was prompted by the U.S. Department of Energy's (DOE) announcement that consideration was being given to locating high-level nuclear waste repository sites in these counties and by the concern over what impacts operation of such sites might have on the ground-water resources in the area. The results of the study, including a discussion of the occurrence of ground water and a tabulation of basic data obtained during the investigation are presented in this report.

  6. Visual assessments for Swisher County and Deaf Smith County locations, Palo Duro Basin, Texas

    SciTech Connect

    Not Available

    1984-12-01

    The area of the Swisher and Deaf Smith County locations is characterized by vast open spaces with limited vertical relief and vegetative cover. The stream valleys and areas around the playa lakes provide the only significant topographical relief in either location, and the areas in range vegetation provide the only major contrast to the dominant land cover of agricultural crops. Tree stands occur almost exclusively in association with orchards, country clubs, farmsteads, and urban areas. Because of climatic conditions in the region, there are few permanent water bodies in either location. Grain elevators, farmsteads, and other cultural modifications (roads, utility lines, fence rows, etc.) are scattered throughout both locations, but they constitute a very small portion of the visible landscape. These features help provide scale in the landscape and also serve as visual landmarks.

  7. Site Study Plan for laboratory soil mechanics, Deaf Smith County site, Texas: Revision 1

    SciTech Connect

    Not Available

    1987-12-01

    This Site Study Plan for laboratory soil mechanics describes the laboratory testing to be conducted on soil samples collected as part of the characterization of the Deaf Smith County site, Texas. This study provides for measurements of index, mechanical, thermal, hydrologic, chemical, and mineral properties of soils from boring throughout the site. Samples will be taken from Playa Borings/Trenching, Transportation/Utilities Foundation Borings, Repository Surface Facilities Design Foundation Borings, and Exploratory Shaft Facilities Design Foundation Borings. Data from the laboratory tests will be used for soil strata characterization, design of foundations for surface structures, design of transportation facilities and utility structures, design of impoundments, design of shaft lining, design of the shaft freeze wall, shaft permitting, performance assessment calculations, and other program requirements. A tentative testing schedule and milestone log are given. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that appropriate documentation is maintained. 18 refs., 6 figs., 3 tabs.

  8. Cultural resources: Deaf Smith and Swisher County locations, Palo Duro Basin, Texas

    SciTech Connect

    Not Available

    1984-12-01

    Cultural resources are prehistoric and historic sites, including archeological and paleontological sites, that are important to a group of people. They are protected by both federal and state legislation. In the area covered by the Deaf Smith and Swisher County locations, four stages of cultural development have been identified: Paleo-Indian, Archaic, Ceramic (Neo-Indian or Neo-American), and Historic. Areas where undiscovered cultural resources are most likely to be found include sources of water, playa lakes, and historic trails. Because extensive surveying has not been done in either location, the number of identified sites is low. However, the potential for finding undiscovered sites is high for significant parts of both locations.

  9. Site study plan for Playa investigations, Deaf Smith County, Texas: Salt Repository Project

    SciTech Connect

    Not Available

    1987-04-02

    This plan defines the purpose and objectives of the Playa Investigation Study, presents a plan of work to provide the information necessary to resolve issues, and discusses the rationale for test method selection. The required information will be obtained from existing well drilling records, describing and testing of soil and rock samples recovered from project test holes, geophysical well logs, seismic surveys, and shallow test pits excavated at ground surface. There have been numerous, often conflicting, theories presented to explain the origin(s) of the playas of the Texas High Plains. The primary purpose of this study is to establish if existing playas and playa alignments are related to deeper subsurface structure, such as faulting or salt dissolution, the potential for future playa development, and the significance of existing and/or future playas on siting a repository in Deaf Smith County, Texas. 11 refs.

  10. Evaluation of air quality and noise impact assessments, Deaf Smith County

    SciTech Connect

    Not Available

    1986-05-01

    In this report, several issues are identified regarding the air quality and noise impact assessments presented in the final salt repository environmental assessment (EA) prepared by the US Department of Energy for the Deaf Smith County, Texas, site. Necessary revisions to the data and methods used to develop the EA impact assessment are described. Then, a comparative evaluation is presented in which estimated impacts based upon the revised data and methods are compared with the impacts published in the EA. The evaluation indicates that the conclusions of the EA air quality and noise impacts sections would be unchanged. Consequently, the guideline findings presented in Chapter 6 of the EA are also unchanged by the revised analysis. 13 tabs.

  11. A Turkish patient with large 17p11.2 deletion presenting with Smith Magenis syndrome.

    PubMed

    Tug, E; Cine, N; Aydin, H

    2011-01-01

    Smith-Magenis syndrome (SMS), which occurs as a result of an interstitial deletion within chromosome 17p11.2-p12, is a disorder that presents itself with minor dysmorphic features, brachydactyly, short stature, hypotonia, delayed speech, cognitive deficits and neurobehavioral problems including sleep disturbances and maladaptive repetitive and self-injurious behavior. We present a girl with full SMS phenotype. G-banding cytogenetic analysis showed normal 46,XX karyotype. Whole-genome array comparative genomic hybridization (CGH) was performed due to the severity of the phenotype and the unusual features present in the patient. An interstitial deletion in 17p11.2-p12, approximately 4.73 Mb in size was determined. Characteristic physical and behavioral phenotype strongly suggested SMS. This, to the best of our knowledge is the first patient with SMS reported in Turkey. We emphasize the need for whole genome analysis in multiple congenital abnormalities/mental retardation disorders with unusual and severe phenotypes.

  12. Non-invasive ventilation for sleep-disordered breathing in Smith-Magenis syndrome.

    PubMed

    Connor, Victoria; Zhao, Sizheng; Angus, Robert

    2016-08-05

    Smith-Magenis syndrome (SMS) is a rare genetic neurodevelopmental disorder characterised by behavioural disturbances, intellectual disability and early onset obesity. The physical features of this syndrome are well characterised; however, behavioural features, such as sleep disturbance, are less well understood and difficult to manage. Sleep issues in SMS are likely due to a combination of disturbed melatonin cycle, facial anatomy and obesity-related ventilatory problems. Sleep disorders can be very distressing to patients and their families, as exemplified by our patient's experience, and can worsen behavioural issues as well as general health. This case demonstrates the successful use of non-invasive ventilation in treating underlying obesity hypoventilation syndrome and obstructive sleep apnoea. As a consequence of addressing abnormalities in sleep patterns, some behavioural problems improved.

  13. Forgotten records of Chrysopelea taprobanica Smith, 1943 (Squamata: Colubridae) from India.

    PubMed

    Somaweera, Ruchira; Pantoja, Davi Lima; Deepak, V

    2015-04-17

    The colubrid snake Chrysopelea taprobanica Smith, 1943 was described from a holotype from Kanthali (= Kantalai) and paratypes from Kurunegala, both localities in Sri Lanka (formerly Ceylon) (Smith 1943). Since its description, literature pertaining to Sri Lankan snake fauna considered this taxon to be endemic to the island (Taylor 1950, Deraniyagala 1955, de Silva 1980, de Silva 1990, Somaweera 2004, Somaweera 2006, de Silva 2009, Pyron et al. 2013). In addition, earlier efforts on the Indian peninsula (e.g. Das 1994, 1997, Das 2003, Whitaker & Captain 2004, Aengals et al. 2012) and global data compilations (e.g. Wallach et al. 2014, Uetz & Hošek 2015) did not identify any record from mainland India until Guptha et al. (2015) recorded a specimen (voucher BLT 076 housed at Bio-Lab of Seshachalam Hills, Tirupathi, India) in the dry deciduous forest of Chamala, Seshachalam Biosphere Reserve in Andhra Pradesh, India in November 2013. Guptha et al. (2015) further mentioned an individual previously photographed in 2000 at Rishi Valley, Andhra Pradesh, but with no voucher specimen collected. Guptha's record, assumed to be the first confirmed record of C. taprobanica in India, is noteworthy as it results in a large range extension, from northern Sri Lanka to eastern India with an Euclidean distance of over 400 km, as well as a change of status, i.e., species not endemic to Sri Lanka. However, at least three little-known previous records of this species from India evaded most literature and were overlooked by the researchers including ourselves.

  14. The Effect of Mixing on the Observed Metallicity of the Smith Cloud

    NASA Astrophysics Data System (ADS)

    Henley, David B.; Gritton, Jeffrey A.; Shelton, Robin L.

    2017-03-01

    Measurements of high-velocity clouds’ metallicities provide important clues about their origins, and hence on whether they play a role in fueling ongoing star formation in the Galaxy. However, accurate interpretation of these measurements requires compensating for the galactic material that has been mixed into the clouds. In order to determine how much the metallicity changes as a result of this mixing, we have carried out three-dimensional wind-tunnel-like hydrodynamical simulations of an example cloud. Our model cloud is patterned after the Smith Cloud, a particularly well studied cloud of mass ∼ 5× {10}6 {M}ȯ . We calculated the fraction of the high-velocity material that had originated in the galactic halo, {F}{{h}}, for various sight lines passing through our model cloud. We find that {F}{{h}} generally increases with distance from the head of the cloud, reaching ∼0.5 in the tail of the cloud. Models in which the metallicities (relative to solar) of the original cloud, {Z}{cl}, and of the halo, {Z}{{h}}, are in the approximate ranges 0.1≲ {Z}{cl}≲ 0.3 and 0.7≲ {Z}{{h}}≲ 1.0, respectively, are in rough agreement with the observations. Models with {Z}{{h}}∼ 0.1 and {Z}{cl}≳ 0.5 are also in rough agreement with the observations, but such a low halo metallicity is inconsistent with recent independent measurements. We conclude that the Smith Cloud’s observed metallicity may not be a true reflection of its original metallicity and that the cloud’s ultimate origin remains uncertain.

  15. Final Report - Conservation & Renewable Energy Potential Study For Smith River Rancheria

    SciTech Connect

    Greg Retzlaff

    2007-07-01

    In January 2006 the Smith River Rancheria (SRR), located in Smith River, California, contracted with the team of Strategic Energy Solutions (SES) and Evergreen NRG to conduct a study for the community. The objective of the study was to identify renewable generation opportunities that would facilitate Rancheria energy independence through SRR owned and operated power projects. These generation facilities were to be located either on or near the reservation. Specifically, the Rancheria was interested in the viability of generating electric power using biomass and wind fuel resources. Initial research identified that a very small portion of the community's energy could be offset by renewable energy generation due to the low solar resource in this area, and the lack of significant wind or biomass resources on or near reservation land. Some larger projects were identified which offered little or no benefit to the Rancheria. As a result, the scope of this study was changed in October 2006 to focus on energy efficiency opportunities for key reservation facilities, with a continued analysis of smaller renewable energy opportunities within reservation boundaries. The consulting team initially performed a resource analysis for biomass and solar generation opportunities in the region of the Rancheria. It was quickly concluded that none of these options would yield renewable power for the Rancheria at costs competitive with current utility sources, and that any larger installations would require substantial funding that may not be available. Having made these conclusions early on, the study effort was redirected and the team investigated each of the major Rancheria buildings to look for solar, wind and conservation opportunities. The buildings were audited for energy use and the roof areas were examined for exposure of solar radiation. Wind resources were also investigated to determine if smaller wind turbines would offer power generation at a reasonable cost.

  16. THE SMITH CLOUD: HIGH-VELOCITY ACCRETION AND DARK MATTER CONFINEMENT

    SciTech Connect

    Nichols, M.; Bland-Hawthorn, J.

    2009-12-20

    The Smith Cloud is a massive system of metal-poor neutral and ionized gas (M{sub gas} approx> 2 x 10{sup 6} M{sub sun}) that is presently moving at high velocity (V{sub GSR}approx 300 km s{sup -1}) with respect to the Galaxy at a distance of 12 kpc from the Sun. The kinematics of the cloud's cometary tail indicates that the gas is in the process of accretion onto the Galaxy, as first discussed by Lockman et al. Here, we re-investigate the cloud's orbit by considering the possibility that the cloud is confined by a dark matter halo. This is required for the cloud to survive its passage through the Galactic corona. We consider three possible models for the dark matter halo (Navarro-Frenk-White (NFW), Einasto, and Burkert) including the effects of tidal disruption and ram pressure stripping during the cloud's infall onto and passage through the Galactic disk. For the NFW and Einasto dark matter models, we are able to determine reasonable initial conditions for the Smith Cloud, although this is only marginally possible with the Burkert model. For all three models, the progenitor had an initial (gas+dark matter) mass that was an order-of-magnitude higher than inferred today. In agreement with Lockman et al., the cloud appears to have punched through the disk approx70 Myr ago. For our most successful models, the baryon-to-dark matter ratio is fairly constant during an orbital period but drops by a factor of 2-5 after transiting the disk. The cloud appears to have only marginally survived its transit and is unlikely to retain its integrity during the next transit approx 30 Myr from now.

  17. Technical procedures for the implementation of cultural resource site studies, Deaf Smith County, Texas: Preliminary draft

    SciTech Connect

    Not Available

    1987-09-30

    Cultural resources at the Deaf Smith County site will be identified, evaluated and managed through the implementation of studies detailed in the Site Study Plan for Cultural Resources. This technical procedure outlines the conduct of pedestrian survey and the documentation of identified cultural resources. The purpose of the field surveys is to identify and document cultural resources in the areas that will be affected by site characterization activities and to record the environmental setting of identified cultural resources. Three pedestrian surveys will cover 100 percent of the on-site and off-site project areas. Survey 1 will provide coverage of the Repository Surface Facility (RSF) area, which includes the Exploratory Shaft Facility (ESF) and two linear engineering design borehole (EDBH) seismic survey corridors. Survey 2 will provide coverage of a 39 km/sup 2/ (15 mi/sup 2/) area that includes the 23 km/sup 2/ (9 mi/sup 2/) Deaf Smith County site plus a 0.4 to 0.8 kM (1/4 to 1/2 mi) border area but excludes the area covered by Survey 1. Survey 3 will cover offsite geotechnical test areas, such as the locations of playa boreholes, deep playa wells, hydrologic tests, site foundation borings, and their access routes. The purpose of site documentation or recording is to address the project information needs for land use permits and approvals, engineering design support, and cultural resource evaluation for National Register of Historic Places eligibility. Site documentation will consist of gathering sufficient data on identified resources to complete Texas Natural Resource Information System (TNRIS). 7 refs., 3 figs.

  18. Frameshift mutation hotspot identified in Smith-Magenis syndrome: case report and review of literature.

    PubMed

    Truong, Hoa T; Dudding, Tracy; Blanchard, Christopher L; Elsea, Sarah H

    2010-10-08

    Smith-Magenis syndrome (SMS) is a complex syndrome involving intellectual disabilities, sleep disturbance, behavioural problems, and a variety of craniofacial, skeletal, and visceral anomalies. While the majority of SMS cases harbor an ~3.5 Mb common deletion on 17p11.2 that encompasses the retinoic acid induced-1 (RAI1) gene, some patients carry small intragenic deletions or point mutations in RAI1. We present data on two cases of Smith-Magenis syndrome with mutation of RAI1. Both cases are phenotypically consistent with SMS and RAI1 mutation but also have other anomalies not previously reported in SMS, including spontaneous pneumothoraces. These cases also illustrate variability in the SMS phenotype not previously shown for RAI1 mutation cases, including hearing loss, absence of self-abusive behaviours, and mild global delays. Sequencing of RAI1 revealed mutation of the same heptameric C-tract (CCCCCCC) in exon 3 in both cases (c.3103delC one case and and c.3103insC in the other), resulting in frameshift mutations. Of the seven reported frameshift mutations occurring in poly C-tracts in RAI1, four cases (~57%) occur at this heptameric C-tract. Collectively, these results indicate that this heptameric C-tract is a preferential hotspot for single nucleotide insertion/deletions (SNindels) and therefore, should be considered a primary target for analysis in patients suspected for mutations in RAI1. We expect that as more patients are sequenced for mutations in RAI1, the incidence of frameshift mutations in this hotspot will become more evident.

  19. What's All the Noise? Differentiating Dimensions of Acoustic Stress and the Limits to Meta-Analysis: Reply to Smith (2012)

    ERIC Educational Resources Information Center

    Szalma, J. L.; Hancock, P. A.

    2012-01-01

    Smith (2012) has provided pertinent observations on our recently published meta-analytic review (Szalma & Hancock, 2011) of the effects of acoustic noise on performance. His main points are as follows: (a) our review excluded some areas of research; (b) there were conceptual problems with our moderator analyses; and (c) limitations to…

  20. Preserving Precious Instruments in Mathematics History: The Educational Museum of Teachers College and David Eugene Smith's Collection

    ERIC Educational Resources Information Center

    Murray, Diane R.

    2011-01-01

    A history is given of the Educational Museum of Teachers College, which began in 1886, and David Eugene Smith's extensive collection of mathematical tools used in the Museum's exhibits is discussed. Historic mathematical instruments including, the astrolabe, abacus and counting rods, and the slide rule are examined. The author uses digitized…

  1. Boys, Be Ambitious: William Smith Clark and the Westernisation of Japanese Agricultural Extension in the Meiji Era

    ERIC Educational Resources Information Center

    Gowen, Garrett; Friedensen, Rachel; Kimball, Ezekiel

    2016-01-01

    This article examines the historiography related to the 1876 founding of Sapporo Agricultural College, the first institution of its kind in Japan. Focusing specifically on the involvement of William Smith Clark, who previously served as the president of the Massachusetts Agricultural College, it argues that the nascent imperial ambitions harboured…

  2. Sensory Motor and Functional Skills of Dizygotic Twins: One with Smith-Magenis Syndrome and a Twin Control

    ERIC Educational Resources Information Center

    Smith, Michaele R.; Hildenbrand, Hanna; Smith, Ann C. M.

    2009-01-01

    Smith-Magenis syndrome (SMS), the result of an interstitial deletion within chromosome 17p11.2, is a disorder that may include minor dysmorphic features, brachydactyly, short stature, hypotonia, speech delays, cognitive deficits, signs of peripheral neuropathy, scoliosis, and neurobehavioral problems including sleep disturbances and maladaptive…

  3. Analysis of Dead Time and Implementation of Smith Predictor Compensation in Tracking Servo Systems for Small Unmanned Aerial Vehicles

    DTIC Science & Technology

    2005-12-01

    onboard serial controller, a data processing delay within that controller, and the mechanical delays of the gimbal. This thesis applies system ... identification techniques to the servo controller system and considers the implementation of a Smith Predictor into the camera control algorithm in order to reduce the overall effect of the lag on the system performance.

  4. Commentary: Cause for Alarm? Youth and Internet Risk Research--A Commentary on Livingstone and Smith (2014)

    ERIC Educational Resources Information Center

    Finkelhor, David

    2014-01-01

    This commentary on Livingstone and Smith (2014) suggests that more attention should be paid to a set of hypotheses about technology that contrasts with those that have animated much of the current research interest: (a) That the digital environment is no more perilous and perhaps less perilous than other offline environments youth inhabit; (b)…

  5. An Indirect Examination of the Function of Problem Behavior Associated with Fragile X Syndrome and Smith-Magenis Syndrome

    ERIC Educational Resources Information Center

    Langthorne, Paul; McGill, Peter

    2012-01-01

    Fragile X syndrome (FXS) and Smith-Magenis syndrome (SMS) are associated with a number of specific topographies of problem behavior. Very few studies have examined the function served by problem behavior in these groups. Using the Questions About Behavioral Function scale Matson and Vollmer (User's guide: questions about behavioral function…

  6. 78 FR 66748 - Smith Miller and Patch Inc. et al.; Proposal to Withdraw Approval of 14 New Drug Applications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... Required Reports Have Not Been Made Application No. Drug Applicant NDA 004979 Multi-Vitamin Smith Miller...) Tablets. NDA 008326 Methischol (inositol/ USV Pharmaceutical vitamin B12/ Corp., 500 Virginia... of fact that requires a hearing. Reports submitted to remedy the deficiencies must be complete in...

  7. Siblings of Individuals with Smith-Magenis Syndrome: An Investigation of the Correlates of Positive and Negative Behavioural Traits

    ERIC Educational Resources Information Center

    Moshier, M. S.; York, T. P.; Silberg, J. L.; Elsea, S. H.

    2012-01-01

    Background: Smith-Magenis syndrome (SMS) is a neurodevelopmental disorder that affects approximately one out of 25 000 births worldwide. To date, no research has been conducted to investigate how having an individual with SMS in a family is a positive or negative influence on siblings. Methods: To investigate this question we conducted a study…

  8. The giant resin bee, Megachile sculpturalis Smith: new distributional records for the mid- and gulf-south USA

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Megachile (Callomegachile) sculpturalis Smith, the giant resin bee, is an adventive species in the United States. First established in the United States during the early 1990s, records currently exist from most states east of the Mississippi River along with Iowa and Kansas. New distributional recor...

  9. 77 FR 48827 - Changes To Implement the Supplemental Examination Provisions of the Leahy-Smith America Invents...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ...The United States Patent and Trademark Office (Office) is revising the rules of practice in patent cases to implement the supplemental examination provisions of the Leahy-Smith America Invents Act (AIA). The supplemental examination provisions permit a patent owner to request supplemental examination of a patent by the Office to consider, reconsider, or correct information believed to be......

  10. 77 FR 3666 - Changes To Implement the Supplemental Examination Provisions of the Leahy-Smith America Invents...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ...The United States Patent and Trademark Office (Office) is proposing to amend the rules of practice in patent cases to implement the supplemental examination provisions of the Leahy-Smith America Invents Act. The supplemental examination provisions permit a patent owner to request supplemental examination of a patent by the Office to consider, reconsider, or correct information believed to be......

  11. "And This Is How You Shall Ask": Linguistics, Anthropology, and Education in the Work of David Smith

    ERIC Educational Resources Information Center

    Gilmore, Perry; McDermott, Ray

    2006-01-01

    This article celebrates the life and work of David M. Smith, former Council on Anthropology and Education president and founder of the University of Pennsylvania Ethnography in Education Research Forum, tracing his contributions to the fields of linguistics, anthropology, and education through the dual lens of his ten research principles and Walt…

  12. 75 FR 16099 - Mr. Jerry McMillan and Ms. Christine Smith; Notice of Termination of License by Implied Surrender...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... Energy Regulatory Commission Mr. Jerry McMillan and Ms. Christine Smith; Notice of Termination of License... Proceeding: Termination of license by implied surrender b. Project No.: P-9907-018 c. Licensees: Mr. Jerry Mc... Contact: Mr. Jerry McMillan, 1157 North Hughes Street, Centerville, UT 84014, (801) 808-6997. h....

  13. 78 FR 11059 - Examination Guidelines for Implementing the First Inventor To File Provisions of the Leahy-Smith...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-14

    ...The United States Patent and Trademark Office (Office) is publishing examination guidelines concerning the first inventor to file provisions of the Leahy-Smith America Invents Act (AIA). The AIA amends the patent laws pertaining to the conditions of patentability to convert the U.S. patent system from a ``first to invent'' system to a ``first inventor to file'' system, treats patents and......

  14. Reflections on a Proposed Theory of Reservation-Dwelling American Indian Alcohol Use: Comment on Spillane and Smith (2007)

    ERIC Educational Resources Information Center

    Beals, Janette; Belcourt-Dittloff, Annie; Freedenthal, Stacey; Kaufman, Carol; Mitchell, Christina; Whitesell, Nancy; Albright, Karen; Beauvais, Fred; Belcourt, Gordon; Duran, Bonnie; Fleming, Candace; Floersch, Natasha; Foley, Kevin; Jervis, Lori; Kipp, Billie Jo; Mail, Patricia; Manson, Spero; May, Philip; Mohatt, Gerald; Morse, Bradley; Novins, Douglas; O'Connell, Joan; Parker, Tassy; Quintero, Gilbert; Spicer, Paul; Stiffman, Arlene; Stone, Joseph; Trimble, Joseph; Venner, Kamilla; Walters, Karina

    2009-01-01

    In their recent article, N. Spillane and G. Smith suggested that reservation-dwelling American Indians have higher rates of problem drinking than do either non-American Indians or those American Indians living in nonreservation settings. These authors further argued that problematic alcohol use patterns in reservation communities are due to the…

  15. Winter sound-level characterization of the Deaf Smith County location in the Palo Duro Basin, Texas

    SciTech Connect

    Not Available

    1984-03-01

    A description of sound levels and sound sources in the Deaf Smith County location in the Palo Duro Basin during a period representative of the winter season is presented. Data were collected during the period February 26 through March 1, 1983. 4 references, 1 figure, 3 tables.

  16. Summer sound-level characterization of the Deaf Smith County and Swisher County locations in the Palo Duro Basin, Texas

    SciTech Connect

    Not Available

    1984-03-01

    A description of sound levels and sound sources in the Deaf Smith County and Swisher County locations in the Palo Duro Basin during a period representative of the summer season is presented. Included are data collected during the period August 4 through 8, 1982, for both locations. 3 references, 2 figures, 3 tables.

  17. Pediatric bupropion-induced serum sicknesslike reaction.

    PubMed

    Hack, Sabine

    2004-01-01

    This reports the first 2 cases of serum sicknesslike reaction to bupropion in children (age 12 and 14). Serum sicknesslike reactions are an example of immune-complex medicated disease. The cardinal symptoms of serum sickness are fever, lymphadenopathy, arthralgias or arthritis, and urticaria. Symptoms usually resolve without long-term sequela following discontinuation of the exogenous antigen. It is likely that serum sicknesslike reactions to bupropion are either relatively rare or underrecognized and underreported. Between May 1998 and May 2001, GlaxoSmith Kline received 172 reports of seizures (a well-known adverse drug reaction) and only 37 reports of serum sicknesslike reactions (Wooltorton 2002). We do not know if children and adolescents are more prone than adults to develop serum sicknesslike reactions to bupropion. Luckily, the reported cases of serum sicknesslike reactions to bupropion have not caused irreversible morbidity or mortality. Nevertheless, the symptoms are painful, temporarily disfiguring and disabling, and warrant prompt medical attention. Parents and patients should be educated about this potential side effect at the onset of treatment, because symptoms are similar to many infectious childhood illnesses, and the treatment of serum sicknesslike reactions to bupropion should include the discontinuation of bupropion.

  18. Methods in Clinical Pharmacology Series

    PubMed Central

    Beaumont, Claire; Young, Graeme C; Cavalier, Tom; Young, Malcolm A

    2014-01-01

    Human radiolabel studies are traditionally conducted to provide a definitive understanding of the human absorption, distribution, metabolism and excretion (ADME) properties of a drug. However, advances in technology over the past decade have allowed alternative methods to be employed to obtain both clinical ADME and pharmacokinetic (PK) information. These include microdose and microtracer approaches using accelerator mass spectrometry, and the identification and quantification of metabolites in samples from classical human PK studies using technologies suitable for non-radiolabelled drug molecules, namely liquid chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy. These recently developed approaches are described here together with relevant examples primarily from experiences gained in support of drug development projects at GlaxoSmithKline. The advantages of these study designs together with their limitations are described. We also discuss special considerations which should be made for a successful outcome to these new approaches and also to the more traditional human radiolabel study in order to maximize knowledge around the human ADME properties of drug molecules. PMID:25041729

  19. New antiepileptic medication linked to blue discoloration of the skin and eyes.

    PubMed

    Clark, Sarah; Antell, Alexandra; Kaufman, Kimberly

    2015-02-01

    Ezogabine is an antiepileptic medication approved in June 2011 by the US Food and Drug Administration (FDA) as an adjunctive treatment for partial seizures. Minimal drug interactions and a novel mechanism of action made ezogabine an appealing new treatment option. However, adverse effects reported during clinical trials and following drug approval have been alarming. A Risk Evaluation Mitigation Strategy (REMS) program has been established for urinary retention. A safety alert was published in April 2013 warning ezogabine may cause retinal pigment abnormalities and/or blue-gray discoloration, most notably on or near the lips, nail beds, sclera and conjunctiva with long-term use. In October 2013, the FDA announced a formal label change to ezogabine to include a black boxed warning emphasizing the previously reported warnings of eye and skin discoloration and permanent vision changes. Given the unknown nature of the pathophysiology, consequences and potential for reversibility of these effects, GlaxoSmithKline and the FDA have published recommendations for patients currently receiving ezogabine. Further data from published case reports and long-term safety trials in the future may lend additional insight into these concerning effects.

  20. Evidence-based guidelines for the care and maintenance of complete dentures: a publication of the American College of Prosthodontists.

    PubMed

    Felton, David; Cooper, Lyndon; Duqum, Ibrahim; Minsley, Glenn; Guckes, Albert; Haug, Steven; Meredith, Patricia; Solie, Caryn; Avery, David; Deal Chandler, Nancy

    2011-02-01

    The current rates of edentulism have been estimated to be between 7% and 69% of the adult population internationally. In the United States, while the incidence of edentulism continues to decline, rapid population growth coupled with current economic conditions suggest that edentulism and conventional denture use will continue at current or higher numbers. Unfortunately, evidence-based guidelines for the care and maintenance of removable complete denture prostheses do not exist. In 2009, the American College of Prosthodontists (ACP) formed a task force to establish evidence-based guidelines for the care and maintenance of complete dentures. The task force comprised members of the ACP, the Academy of General Dentistry, American Dental Association (ADA) Council on Scientific Affairs, the American Dental Hygienists' Association, the National Association of Dental Laboratories, and representatives from GlaxoSmithKline Consumer Healthcare. The review process included the assessment of over 300 abstracts and selection of over 100 articles meeting inclusion criteria of this review. The task force reviewed synopses of the literature and formulated 15 evidence-based guidelines for denture care and maintenance. These guidelines were reviewed by clinical experts from the participating organizations and were published in February 2011 issue of The Journal of the American Dental Association for widespread distribution to the dental community. These guidelines reflect the views of the task force.

  1. Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

    PubMed

    Liu, Jason Z; Tozzi, Federica; Waterworth, Dawn M; Pillai, Sreekumar G; Muglia, Pierandrea; Middleton, Lefkos; Berrettini, Wade; Knouff, Christopher W; Yuan, Xin; Waeber, Gérard; Vollenweider, Peter; Preisig, Martin; Wareham, Nicholas J; Zhao, Jing Hua; Loos, Ruth J F; Barroso, Inês; Khaw, Kay-Tee; Grundy, Scott; Barter, Philip; Mahley, Robert; Kesaniemi, Antero; McPherson, Ruth; Vincent, John B; Strauss, John; Kennedy, James L; Farmer, Anne; McGuffin, Peter; Day, Richard; Matthews, Keith; Bakke, Per; Gulsvik, Amund; Lucae, Susanne; Ising, Marcus; Brueckl, Tanja; Horstmann, Sonja; Wichmann, H-Erich; Rawal, Rajesh; Dahmen, Norbert; Lamina, Claudia; Polasek, Ozren; Zgaga, Lina; Huffman, Jennifer; Campbell, Susan; Kooner, Jaspal; Chambers, John C; Burnett, Mary Susan; Devaney, Joseph M; Pichard, Augusto D; Kent, Kenneth M; Satler, Lowell; Lindsay, Joseph M; Waksman, Ron; Epstein, Stephen; Wilson, James F; Wild, Sarah H; Campbell, Harry; Vitart, Veronique; Reilly, Muredach P; Li, Mingyao; Qu, Liming; Wilensky, Robert; Matthai, William; Hakonarson, Hakon H; Rader, Daniel J; Franke, Andre; Wittig, Michael; Schäfer, Arne; Uda, Manuela; Terracciano, Antonio; Xiao, Xiangjun; Busonero, Fabio; Scheet, Paul; Schlessinger, David; St Clair, David; Rujescu, Dan; Abecasis, Gonçalo R; Grabe, Hans Jörgen; Teumer, Alexander; Völzke, Henry; Petersmann, Astrid; John, Ulrich; Rudan, Igor; Hayward, Caroline; Wright, Alan F; Kolcic, Ivana; Wright, Benjamin J; Thompson, John R; Balmforth, Anthony J; Hall, Alistair S; Samani, Nilesh J; Anderson, Carl A; Ahmad, Tariq; Mathew, Christopher G; Parkes, Miles; Satsangi, Jack; Caulfield, Mark; Munroe, Patricia B; Farrall, Martin; Dominiczak, Anna; Worthington, Jane; Thomson, Wendy; Eyre, Steve; Barton, Anne; Mooser, Vincent; Francks, Clyde; Marchini, Jonathan

    2010-05-01

    Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.

  2. Pharma TARP: a troubled asset relief program for novel, abandoned projects in the pharmaceutical industry.

    PubMed

    Bartfai, Tamas; Lees, Graham Vaughan

    2011-02-14

    Within days of each other, Pfizer, Merck, and GlaxoSmithKline announced that they will focus on a few therapeutic areas only and abandon others entirely. Pfizer alone will close well over a hundred drug development projects that have reached two-thirds of the way to launch. The programs are deemed to be too risky and not lucrative enough for Big Pharma in the current climate. Society has a real need for the drugs that are no longer going to be developed for, among others, drug-resistant epilepsy, neuropathic and cancer pain, type-2 diabetes, obesity, and schizophrenia. The authors propose a radical response by the U.S. government and the National Institutes of Health to rescue these abandoned projects, and to continue selected programs for drug approval by the U.S. Food and Drug Administration and the European Medicines Agency. The investment required is small compared to the Troubled Asset Relief Program bank bail out, but the return on investment in financial terms and in satisfying societal needs makes this proposal attractive.

  3. Recommendations for Use of Meningococcal Conjugate Vaccines in HIV-Infected Persons - Advisory Committee on Immunization Practices, 2016.

    PubMed

    MacNeil, Jessica R; Rubin, Lorry G; Patton, Monica; Ortega-Sanchez, Ismael R; Martin, Stacey W

    2016-11-04

    At its June 2016 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended routine use of meningococcal conjugate vaccine (serogroups A, C, W, and Y; including MenACWY-D [Menactra, Sanofi Pasteur] or MenACWY-CRM [Menveo, GlaxoSmithKline]) for persons aged ≥2 months with human immunodeficiency virus (HIV) infection. ACIP has previously recommended routine vaccination of persons aged ≥2 months who have certain medical conditions that increase risk for meningococcal disease (1), including persons who have persistent (e.g., genetic) deficiencies in the complement pathway (e.g., C3, properdin, Factor D, Factor H, or C5-C9); persons receiving eculizumab (Soliris, Alexion Pharmaceuticals) for treatment of atypical hemolytic uremic syndrome or paroxysmal nocturnal hemoglobinuria (because the drug binds C5 and inhibits the terminal complement pathway); and persons with functional or anatomic asplenia (including persons with sickle cell disease). Routine vaccination with meningococcal conjugate vaccine is also recommended for all healthy adolescents in the United States (1). This report summarizes the evidence considered by ACIP in recommending vaccination for HIV-infected persons, and provides recommendations and guidance for use of meningococcal conjugate vaccines (serogroups A, C, W, and Y) among HIV-infected persons aged ≥2 months; the majority of meningococcal disease among HIV-infected persons is caused by these four serogroups.

  4. Is PDE4 too difficult a drug target?

    PubMed

    Higgs, Gerry

    2010-05-01

    The search for selective inhibitors of PDE4 as novel anti-inflammatory drugs has continued for more than 30 years. Although several compounds have demonstrated therapeutic effects in diseases such as asthma, COPD, atopic dermatitis and psoriasis, none have reached the market. A persistent challenge in the development of PDE4 inhibitors has been drug-induced gastrointestinal adverse effects, such as nausea. However, extensive clinical trials with well-tolerated doses of roflumilast (Daxas; Nycomed/Mitsubishi Tanabe Pharma Corp/Forest Laboratories Inc) in COPD, a disease that is generally unresponsive to existing therapies, have demonstrated significant therapeutic improvements. In addition, GlaxoSmithKline plc is developing 256066, an inhaled formulation of a PDE4 inhibitor that has demonstrated efficacy in trials in asthma, and apremilast from Celgene Corp has been reported to be effective for the treatment of psoriasis. Despite the challenges and complications that have been encountered during the development of PDE4 inhibitors, these drugs may provide a genuinely novel class of anti-inflammatory agents, and there are several compounds in development that could fulfill that promise.

  5. Young people's comparative recognition and recall of an Australian Government Sexual Health Campaign.

    PubMed

    Lim, Megan S C; Gold, Judy; Bowring, Anna L; Pedrana, Alisa E; Hellard, Margaret E

    2015-05-01

    In 2009, the Australian Government's National Sexually Transmitted Infection Prevention Program launched a multi-million dollar sexual health campaign targeting young people. We assessed campaign recognition among a community sample of young people. Individuals aged 16-29 years self-completed a questionnaire at a music festival. Participants were asked whether they recognised the campaign image and attempted to match the correct campaign message. Recognition of two concurrent campaigns, GlaxoSmithKline's The Facts genital herpes campaign (targeting young women) and the Drama Downunder campaign (targeting gay men) were assessed simultaneously. Among 471 participants, just 29% recognised the National Sexually Transmitted Infection Prevention Program campaign. This compared to 52% recognising The Facts and 27% recognising Drama Downunder. Of 134 who recognised the National Sexually Transmitted Infection Prevention Program campaign, 27% correctly recalled the campaign messages compared to 61% of those recognising the Facts campaign, and 25% of those recognising the Drama Downunder campaign. There was no difference in National Sexually Transmitted Infection Prevention Program campaign recognition by gender or age. Campaign recognition and message recall of the National Sexually Transmitted Infection Prevention Program campaign was comparatively low. Future mass media sexual health campaigns targeting young people can aim for higher recognition and recall rates than that achieved by the National Sexually Transmitted Infection Prevention Program campaign. Alternative distribution channels and message styles should be considered to increase these rates.

  6. Epidemiological trends for hospital admissions for acute rotavirus gastroenteritis in Belgium following the introduction of routine rotavirus vaccination and the subsequent switch from lyophilized to liquid formulation of Rotarix™.

    PubMed

    Raes, M; Strens, D; Kleintjens, J; Biundo, E; Morel, T; Vyse, A

    2016-10-01

    This study describes epidemiological trends for acute rotavirus gastroenteritis (RVGE) in Belgium in children aged ⩽5 years during the period June 2007 to May 2014 after the introduction of routine rotavirus (RV) vaccination. This period encompassed the switch from lyophilized to the liquid formulation of Rotarix™ (GlaxoSmithKline, Belgium) in August 2011. Uptake of RV vaccine remained consistently high throughout the study period with Rotarix the brand most often used. RV was present in 9% (1139/12 511) of hospitalized cases with acute gastroenteritis included in the study. Epidemiological trends for hospital admissions for RVGE remained consistent throughout the study period, with no evidence of any change associated with the switch from lyophilized to liquid formulation of Rotarix. This suggests both formulations perform similarly, with the liquid formulation not inferior regarding ability to reduce hospital admissions for acute RVGE in children aged ⩽5 years. A strong seasonal effect was observed with most RVGE occurring in the winter months but with some variability in intensity, with highest incidence found in those aged 6-24 months. The main observation was the decreased number of hospital admissions for RVGE in Belgium that occurred during winter 2013/2014.

  7. Fragment-guided approach to incorporating structural information into a CoMFA study: BACE-1 as an example

    NASA Astrophysics Data System (ADS)

    Salum, Lívia Barros; Valadares, Napoleão Fonseca

    2010-10-01

    Alzheimer's disease is an ultimately fatal neurodegenerative disease, and BACE-1 has become an attractive validated target for its therapy, with more than a hundred crystal structures deposited in the PDB. In the present study, we present a new methodology that integrates ligand-based methods with structural information derived from the receptor. 128 BACE-1 inhibitors recently disclosed by GlaxoSmithKline R&D were selected specifically because the crystal structures of 9 of these compounds complexed to BACE-1, as well as five closely related analogs, have been made available. A new fragment-guided approach was designed to incorporate this wealth of structural information into a CoMFA study, and the methodology was systematically compared to other popular approaches, such as docking, for generating a molecular alignment. The influence of the partial charges calculation method was also analyzed. Several consistent and predictive models are reported, including one with r 2 = 0.88, q 2 = 0.69 and r pred 2 = 0.72. The models obtained with the new methodology performed consistently better than those obtained by other methodologies, particularly in terms of external predictive power. The visual analyses of the contour maps in the context of the enzyme drew attention to a number of possible opportunities for the development of analogs with improved potency. These results suggest that 3D-QSAR studies may benefit from the additional structural information added by the presented methodology.

  8. Standing on the Shoulders of Stem Cell Gene Therapists: History, Hyperbole, and Hope for the Future.

    PubMed

    Gardner, Jason

    2016-12-01

    A new type of medicine approved in Europe at the end of May represents the culmination of the successful convergence of two fields of science: stem cell transplantation and gene therapy. Strimvelis, a patient-specific gene-modified stem cell medicine for ADA-SCID (adenosine deaminase deficiency leading to severe combined immunodeficiency; a fatal immunometabolic disorder similar to the bubble-boy disease), was developed by scientists at the San Raffaele Telethon Institute for Gene Therapy (TIGET) in Milan, Italy, which then later partnered with GlaxoSmithKline (GSK, Brentford, UK). The journey took more than 25 years of dedicated work by many groups and involved a pivotal trial with 12 children and their brave families. I was fortunate to be involved on the GSK side of the TIGET alliance from 2010 to 2015, building on my previous experiences with gene-modified stem cells during a postdoctoral fellowship in the mid-1990s and at Chiron, which had acquired Viagene, an early gene therapy biotech firm. I thought it was timely to pick out a couple of observations from the development of Strimvelis, to see how these might apply to the future of stem cell gene therapy and perhaps act like shoulders for the related chimeric antigen receptor T-cell (CAR-T) and gene-editing technologies to stand on.

  9. A vaccine manufacturer's approach to address medical needs related to seasonal and pandemic influenza viruses.

    PubMed

    Baras, Benoit; Bouveret, Nancy; Devaster, Jeanne-Marie; Fries, Louis; Gillard, Paul; Sänger, Roland; Hanon, Emmanuel

    2008-11-01

    Vaccination is considered to be one of the most effective tools to decrease morbidity as well as mortality caused by influenza viruses. For the prevention of seasonal influenza, Fluarix and FluLaval have been marketed since 1987 and 1992, respectively. Both vaccines have consistently been shown to meet or exceed the regulatory criteria for immunogenicity against the three strains H1N1, H3N2 and B, have a good safety profile, and are recommended for vaccinating children and adults of all ages. For the prevention of pandemic influenza, GlaxoSmithKline (GSK) has obtained licensure of a pre-pandemic vaccine, Prepandrix. This split-virus H5N1 adjuvanted with AS03, a proprietary oil-in-water emulsion-based adjuvant system, has demonstrated broad immunity against drifted H5N1 strains and has been shown to be effective in preventing mortality and viral shedding in animal studies. The influenza vaccine portfolio of GSK addresses specific medical needs related to seasonal or pandemic influenza viruses, which remain an important public health threat worldwide.

  10. Identification of “Preferred” Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

    PubMed Central

    2016-01-01

    A kinase-targeting cell-based high-throughput screen (HTS) against Trypanosoma brucei was recently reported, and this screening set included the Published Kinase Inhibitor Set (PKIS). From the PKIS was identified 53 compounds with pEC50 ≥ 6. Utilizing the published data available for the PKIS, a statistical analysis of these active antiparasitic compounds was performed, allowing identification of a set of human kinases having inhibitors that show a high likelihood for blocking T. brucei cellular proliferation in vitro. This observation was confirmed by testing other established inhibitors of these human kinases and by mining past screening campaigns at GlaxoSmithKline. Overall, although the parasite targets of action are not known, inhibitors of this set of human kinases displayed an enhanced hit rate relative to a random kinase-targeting HTS campaign, suggesting that repurposing efforts should focus primarily on inhibitors of these specific human kinases. We therefore term this statistical analysis-driven approach “preferred lead repurposing”. PMID:26998514

  11. Rotavirus vaccine: a cost effective control measure for India.

    PubMed

    Kumar, Arun; Goel, Manish K; Jain, Ram Bilas; Khanna, Pardeep; Vibha, Vibha

    2012-04-01

    Globally, rotavirus diarrhea results in 453,000 deaths in children younger than 5 y—37% of deaths attributable to diarrhea and 5% of all deaths in children younger than 5 y. India alone accounts for 22% (~100,000 deaths) of all deaths attributable to rotavirus infection. Two oral rotavirus vaccines are available: Rotarix, a monovalent P1A[8] G1 vaccine (GlaxoSmithKline), and RotaTeq, a pentavalent bovine-human reassortant vaccine (Merck). Rotarix is administered in a 2-dose schedule with the first and second doses of DTP (DTP1, DTP2). RotaTeq requires a 3-dose schedule with DTP1, DTP2 and DTP3 with an interval of 4–10 weeks between doses. The first dose of either vaccine should be administered to infants aged 6–15 weeks irrespective of the history of previous rotavirus infection, and the maximum age for administering the last dose of either vaccine should be 32 weeks. Although India would require funding from international health organizations/GAVI until new indigenous rotavirus vaccine candidates are developed at a cheaper price, introduction of vaccination into the national immunization program would be a cost-effective step toward control of the rotavirus diarrhea-related morbidity and mortality in India.

  12. Pattern of functional antibody activity against Haemophilus influenzae type B (Hib) in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine.

    PubMed

    Matos, D C S; Silva, A M V; Neves, P C C; Martins, R M; Homma, A; Marcovistz, R

    2009-12-01

    We evaluated the functional activity of Haemophilus influenzae B (Hib) antibodies elicited in a group of infants immunized with the diphtheria-tetanus-pertussis vaccine combined with an Hib vaccine produced totally in Brazil after technological transfer of Hib vaccine production from Glaxo SmithKline, Belgium. Blood samples from immunized infants (N = 985) were collected for the determination of Hib antibodies. Total Ig and IgM and IgG subclasses of antibodies against polyribosyl ribitol phosphate (PRP) were analyzed by ELISA. Almost all vaccinees (97.56%, 961/985) developed a strong anti-PRP IgG antibody response (>or=1.0 microg/mL), while an anti-PRP IgM response was observed in 64.24% (634/985) of them (>or=0.15 microg/mL). Only 18.88% (186/985) of the infants in the group with high PRP antibody IgG concentrations (>or=1.0 microg/mL) developed a high IgM antibody response. Anti-PRP IgG antibody levels were significantly higher than anti-PRP IgM. These results demonstrate the predominance of IgG antibodies over IgM antibodies in response to PRP, with a ratio of 17:1. IgG antibodies were predominantly of the IgG1 subclass. An increase in IgG avidity was also observed during the course of immunization.

  13. Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference.

    PubMed

    Wahren, Britta; Biswas, Priscilla; Borggren, Marie; Coleman, Adam; Da Costa, Kelly; De Haes, Winni; Dieltjens, Tessa; Dispinseri, Stefania; Grupping, Katrijn; Hallengärd, David; Hornig, Julia; Klein, Katja; Mainetti, Lara; Palma, Paolo; Reudelsterz, Marc; Seifried, Janna; Selhorst, Philippe; Sköld, Annette; Uchtenhagen, Hannes; van Gils, Marit J; Weber, Caroline; Shattock, Robin; Scarlatti, Gabriella

    2010-07-26

    EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated research program in the field of HIV vaccines and microbicides to training, dissemination and advocacy. The research program covers the whole pipeline of vaccine and microbicide development from discovery to early clinical trials. The Network is composed of 58 partners representing more than 65 institutions from 13 European countries; it also includes three major pharmaceutical companies (GlaxoSmithKline, Novartis and Sanofi-Pasteur) involved in HIV microbicide and vaccine research. The Network displays a dedicated and informative web page: http://www.europrise.org. Finally, a distinguishing trait of EUROPRISE is its PhD School of students from across Europe, a unique example in the world of science aimed at spreading excellence through training. EUROPRISE held its second annual conference in Budapest in November, 2009. The conference had 143 participants and their presentations covered aspects of vaccine and microbicide research, development and discovery. Since training is a major task of the Network, the students of the EUROPRISE PhD program summarized certain presentations and their view of the conference in this paper.

  14. Building laboratory capacity to support the global rotavirus surveillance network.

    PubMed

    2013-05-24

    In 2001, in anticipation of rotavirus vaccine licensure and introduction, the World Health Organization (WHO) and partners established regional laboratory surveillance networks for rotavirus detection and strain type monitoring among hospitalized children aged <5 years. In 2006, two WHO-prequalified oral rotavirus vaccines were licensed: a 2-dose, single-strain vaccine (Rotarix, GlaxoSmithKline Biologicals) and a 3-dose, multistrain vaccine (RotaTeq, Merck). Both vaccines provide protection against a range of rotavirus strain types, generally classified as G and P types based on specific viral proteins. Based on results of clinical trial data, disease burden data from surveillance networks, and findings from vaccine impact studies, WHO recommends that all countries include rotavirus vaccination in national immunization programs. Vaccination is recommended to help reduce the morbidity and mortality associated with rotavirus, a leading cause of diarrhea in children aged <5 years that was responsible for approximately 450,000 deaths in 2008. This report describes the expansion of the regional rotavirus laboratory surveillance networks to a global surveillance network, the implementation of data quality assurance measures to ensure quality laboratory data reporting to support rotavirus surveillance activities, and data reporting through the surveillance network. Timely, quality surveillance data can provide baseline estimates of rotavirus disease burden to inform decisions regarding rotavirus vaccine introduction in national immunization programs and can help monitor the impact of vaccine introduction on disease trends.

  15. Human health risk assessment from the presence of human pharmaceuticals in the aquatic environment.

    PubMed

    Cunningham, Virginia L; Binks, Stephen P; Olson, Michael J

    2009-02-01

    Assessments for potential impact to human health from environmental exposures were carried out for 44 active pharmaceutical ingredients (APIs) marketed by GlaxoSmithKline (GSK), representing approximately 22 general pharmacological classes exhibiting a broad spectrum of therapeutic activities. These assessments use the considerable amount of information available on the human pharmacology and toxicology of the APIs to develop acceptable daily intakes (ADIs) which are believed to be without pharmacological or toxicological effect. With the exception of the anti-cancer drugs and some antibiotics, the minimum dose producing the intended therapeutic effect was typically used as the point of departure for calculation of ADIs. The ADI values were used to generate predicted no effect concentrations from environmental exposure for human health (PNEC(HH)s) from drinking water or fish consumption. These PNECs were compared to predicted environmental concentrations (PECs) calculated using the regional assessment models PhATE for North America and GREAT-ER for Europe. Risk was characterized by calculating the ratio of the 90th percentile PECs to the PNEC(HH)s. For the APIs reported here, these ratios are less than one for all of the compounds, varying from 7x10(-2) to 6x10(-11), indicating that based upon currently available data, these compounds do not appear to pose an appreciable risk to human health from potential environmental exposure from drinking water and fish consumption.

  16. Mining Natural-Products Screening Data for Target-Class Chemical Motifs.

    PubMed

    Coma, Isabel; Bandyopadhyay, Deepak; Diez, Emilio; Ruiz, Emilio Alvarez; de los Frailes, Maria Teresa; Colmenarejo, Gonzalo

    2014-06-01

    In this article, we describe two complementary data-mining approaches used to characterize the GlaxoSmithKline (GSK) natural-products set (NPS) based on information from the high-throughput screening (HTS) databases. Both methods rely on the aggregation and analysis of a large set of single-shot screening data for a number of biological assays, with the goal to reveal natural-product chemical motifs. One of them is an established method based on the data-driven clustering of compounds using a wide range of descriptors,(1)whereas the other method partitions and hierarchically clusters the data to identify chemical cores.(2,3)Both methods successfully find structural scaffolds that significantly hit different groups of discrete drug targets, compared with their relative frequency of demonstrating inhibitory activity in a large number of screens. We describe how these methods can be applied to unveil hidden information in large single-shot HTS data sets. Applied prospectively, this type of information could contribute to the design of new chemical templates for drug-target classes and guide synthetic efforts for lead optimization of tractable hits that are based on natural-product chemical motifs. Relevant findings for 7TM receptors (7TMRs), ion channels, class-7 transferases (protein kinases), hydrolases, and oxidoreductases will be discussed.

  17. Ropinirole for the treatment of restless legs syndrome

    PubMed Central

    Kushida, Clete A

    2006-01-01

    Dopaminergic agents, anticonvulsants, benzodiazepines, opiates, and iron supplementation comprise the classes of medications commonly used to treat restless legs syndrome (RLS), which is a disorder that is estimated to affect about 1 in 10 individuals worldwide and impacts an affected patient’s sleep, mood, daytime function, and quality of life. RLS is characterized by an urge to move the legs that is worse at bedtime and at rest; the symptoms are temporarily relieved by leg movement. It is frequently accompanied by periodic limb movements during sleep (PLMS), which may independently disrupt sleep and may cause daytime drowsiness. Dopaminergic agents are considered to be first-line therapy in the management of RLS as well as PLMS. Ropinirole (Requip®, GlaxoSmithKline) is a dopamine agonist that was the first medication approved by the US Food and Drug Administration (FDA) for the treatment of moderate-to-severe primary RLS. Based on several large-scale clinical trials and open-label clinical series, this medication has been demonstrated to be effective and safe in treating the motor symptoms of RLS and improving sleep quality. PMID:19412490

  18. [Narcolepsy with cataplexy: an autoimmune disease?].

    PubMed

    Jacob, Louis; Dauvilliers, Yves

    2014-12-01

    Narcolepsy type 1 (also named narcolepsy-cataplexy or hypocretin deficiency syndrome) is a rare sleep disorder characterized by excessive daytime sleepiness and cataplexy, plus frequently hypnagogic hallucinations, sleep paralysis and nocturnal sleep disturbances. Narcolepsy type 1 is an immune system-associated disease linked with the destruction of 70.000-90.000 hypocretin neurons notably involved in wakefulness. Among narcoleptic patients, 98% are positive for HLA-DQB1*06:02, a HLA class II allele, against 20-25% in general population. Individuals carrying HLA-DQB1*06:02 have an extraordinary risk to develop narcolepsy (odd ratio: 251). Other genes involved in CD4+ T cells and immune system activation as T-cell receptor α are also associated with narcolepsy. The development of the disease is linked with environmental factors such as influenza and streptococcal infections. Narcolepsy type 1 incidence also increased in Europe following the use of Pandemrix, a 2009 H1N1 AS03-adjuvanted vaccine manufactured by GlaxoSmithKline. Interestingly, such increase was not observed with Arepanrix, another vaccine developed by GSK very similar to Pandemrix.

  19. Clinical Features of Influenza and Acute Respiratory Illness in Older Adults at Least 50 Years of Age in an Outpatient Setting in the Republic of Korea: a Prospective, Observational, Cohort Study.

    PubMed

    Kim, Woo Joo; Lee, Jin Soo; Lee, Chang Kyu; Cheong, Hee Jin; Kim, Mijeong; Monegal, Javier Sawchik; Carneiro, Rute; Kyaw, Moe H; Haguinet, François; Ray, Riju; Matias, Gonçalo

    2017-03-01

    Two prospective, multi-centre, observational studies (GlaxoSmithKline [GSK] identifier No. 110938 and 112519) were performed over 2 influenza seasons (2007-2008 and 2008-2009) in the Republic of Korea (ROK) with the aim to evaluate the burden of laboratory-confirmed influenza (LCI) in patients ≥ 50 years of age seeking medical attention for acute respiratory illness (ARI). The median participant age was 58 years in the 2007-2008 season and 60 years in the 2008-2009 season. LCI was observed in 101/346 (29.2%) of ARI patients in the 2007-2008 season and in 166/443 (37.5%) of ARI patients in the 2008-2009 season. Compared to patients with non-influenza ARI, those with LCI had higher rates of decreased daily activities (60.4% vs. 32.9% in 2007-2008 and 46.4% vs. 25.8% in 2008-2009), work absenteeism (51.1% vs. 25.6% and 14.4% vs. 7.7%), and longer duration of illness. These results indicated that influenza is an important cause of ARI in adults aged 50 and older causing more severe illness than non-influenza related ARI.

  20. Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research

    PubMed Central

    2016-01-01

    Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic agents. However, despite the various treatments utilized for the treatment of cervical cancer, its disease burden remains a global issue. Persistent infection of human papillomavirus (HPV) has been identified as an essential step of pathogenesis of cervical cancer and many other cancers, and nation-wide HPV screening as well as preventative HPV vaccination program have been introduced globally. However, even though the commercially available prophylactic HPV vaccines, Gardasil (Merck) and Cervarix (GlaxoSmithKline), are effective in blocking the entry of HPV into the epithelium of cervix through generation of HPV-specific neutralizing antibodies, they cannot eliminate the pre-existing HPV infection. For these reason, other immunotherapeutic options against HPV-associated diseases, including therapeutic vaccines, have been continuously explored. Therapeutic HPV vaccines enhance cell-mediated immunity targeting HPV E6 and E7 antigens by modulating primarily dendritic cells and cytotoxic T lymphocyte. Our review will cover various therapeutic vaccines in development for the treatment of HPV-associated lesions and cancers. Furthermore, we will discuss the potential of immune checkpoint inhibitors that have recently been adopted and tested for their treatment efficacy against HPV-induced cervical cancer. PMID:27329199

  1. Target Prediction for an Open Access Set of Compounds Active against Mycobacterium tuberculosis

    PubMed Central

    Martínez-Jiménez, Francisco; Papadatos, George; Yang, Lun; Wallace, Iain M.; Kumar, Vinod; Pieper, Ursula; Sali, Andrej; Brown, James R.; Overington, John P.; Marti-Renom, Marc A.

    2013-01-01

    Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), infects an estimated two billion people worldwide and is the leading cause of mortality due to infectious disease. The development of new anti-TB therapeutics is required, because of the emergence of multi-drug resistance strains as well as co-infection with other pathogens, especially HIV. Recently, the pharmaceutical company GlaxoSmithKline published the results of a high-throughput screen (HTS) of their two million compound library for anti-mycobacterial phenotypes. The screen revealed 776 compounds with significant activity against the M. tuberculosis H37Rv strain, including a subset of 177 prioritized compounds with high potency and low in vitro cytotoxicity. The next major challenge is the identification of the target proteins. Here, we use a computational approach that integrates historical bioassay data, chemical properties and structural comparisons of selected compounds to propose their potential targets in M. tuberculosis. We predicted 139 target - compound links, providing a necessary basis for further studies to characterize the mode of action of these compounds. The results from our analysis, including the predicted structural models, are available to the wider scientific community in the open source mode, to encourage further development of novel TB therapeutics. PMID:24098102

  2. Clinical Features of Influenza and Acute Respiratory Illness in Older Adults at Least 50 Years of Age in an Outpatient Setting in the Republic of Korea: a Prospective, Observational, Cohort Study

    PubMed Central

    2017-01-01

    Two prospective, multi-centre, observational studies (GlaxoSmithKline [GSK] identifier No. 110938 and 112519) were performed over 2 influenza seasons (2007–2008 and 2008–2009) in the Republic of Korea (ROK) with the aim to evaluate the burden of laboratory-confirmed influenza (LCI) in patients ≥ 50 years of age seeking medical attention for acute respiratory illness (ARI). The median participant age was 58 years in the 2007–2008 season and 60 years in the 2008–2009 season. LCI was observed in 101/346 (29.2%) of ARI patients in the 2007–2008 season and in 166/443 (37.5%) of ARI patients in the 2008–2009 season. Compared to patients with non-influenza ARI, those with LCI had higher rates of decreased daily activities (60.4% vs. 32.9% in 2007–2008 and 46.4% vs. 25.8% in 2008–2009), work absenteeism (51.1% vs. 25.6% and 14.4% vs. 7.7%), and longer duration of illness. These results indicated that influenza is an important cause of ARI in adults aged 50 and older causing more severe illness than non-influenza related ARI. PMID:28145642

  3. Resource based view of the firm: measures of reputation among health service-sector businesses.

    PubMed

    Smith, Alan D

    2008-01-01

    Application of the strategic leverage of Resource Based View of the Firm (RBV) directly advocates that a company's competitive advantage is derived from its ability to assemble and exploit an appropriate combination of resources (both tangible and intangible assets). The three companies that were selected were Pittsburgh-based companies that were within relatively easy access, representing healthcare service-related industries, and can be reviewed for the principles of the RBV. The particular firms represented a variety of establishments and included Baptist Homes (a long-term care facility), University of Pittsburgh Medical Center (UPMC)(a provider of hospital and other health services), and GlaxoSmithKline, Consumer Healthcare, North America (GSK-CHNA)(a global provider of healthcare products and services). Through the case studies, it was found that not all intangible assets are strategic, and by extension, not all measures of reputation are strategic either. For an intangible asset to be considered strategic, in this case reputation, it must be valuable, rare, imperfectly imitable, and non-substitutable.

  4. A malaria vaccine for travelers and military personnel: Requirements and top candidates.

    PubMed

    Teneza-Mora, Nimfa; Lumsden, Joanne; Villasante, Eileen

    2015-12-22

    Malaria remains an important health threat to non-immune travelers with the explosive growth of global travel. Populations at high risk of acquiring malaria infections include once semi-immune travelers who visit friends and relatives, military forces, business travelers and international tourists with destinations to sub-Saharan Africa, where malaria transmission intensity is high. Most malaria cases have been associated with poor compliance with existing preventive measures, including chemoprophylaxis. High risk groups would benefit immensely from an efficacious vaccine to protect them against malaria infection and together make up a sizable market for such a vaccine. The attributes of an ideal malaria vaccine for non-immune travelers and military personnel include a protective efficacy of 80% or greater, durability for at least 6 months, an acceptable safety profile and compatibility with existing preventive measures. It is very likely that a malaria vaccine designed to effectively prevent infection and clinical disease in the non-immune traveler and military personnel will also protect semi-immune residents of malaria-endemic areas and contribute to malaria elimination by reducing or blocking malaria transmission. The RTS,S vaccine (GlaxoSmithKline) and the PfSPZ Vaccine (Sanaria Inc) are the leading products that would make excellent vaccine candidates for these vulnerable populations.

  5. Hepatitis B specific T cell immunity induced by primary vaccination persists independently of the protective serum antibody level.

    PubMed

    Carollo, Maria; Palazzo, Raffaella; Bianco, Manuela; Pandolfi, Elisabetta; Chionne, Paola; Fedele, Giorgio; Tozzi, Alberto Eugenio; Carsetti, Rita; Romanò, Luisa; Ausiello, Clara Maria

    2013-01-07

    In 2005, in accordance with recommendations made by the European Medicines Agency, the Italian Drug Agency ordered withdrawal of the hexavalent Hexavac(®) vaccine (Sanofi Pasteur MSD) from the market. Concerns had been raised about the low immunogenicity of the hepatitis B virus component of the vaccine, assessed by measurement of serum antibody levels, and its potential consequences on long-term protection against hepatitis B infection. We evaluated memory T cell response to establish whether there are differences in the protective mechanisms among children who had received either Hexavac(®) or Infanrix-hexa(®) (GlaxoSmithKline) as their primary vaccination. Immunological memory was determined by measuring the ability of T cells to proliferate and secrete IFNγ by ELISA and intracellular cytokines (IFNγ and IL-2) when cultured with hepatitis B surface antigen (HBsAg). The different memory subsets of T cells were also measured. The results indicate that, although they generate different serum antibody levels, both vaccines are efficient in generating T recall responses in vitro five years after the primary vaccination. The less immunogenic Hexavac(®) vaccine induces a strong T antigen response, as indicated by increased blast proliferation and the enhanced presence of memory subsets after HBsAg recall stimulation. These findings suggest that cellular immune response should be considered alongside serological markers as a surrogate of protection.

  6. Essential health care package for children--the 'Fit for School' program in the Philippines.

    PubMed

    Monse, Bella; Naliponguit, Ella; Belizario, Vincente; Benzian, Habib; van Helderman, Wim Palenstein

    2010-04-01

    High prevalence of poverty diseases such as diarrhoea, respiratory tract infection, parasitic infections and dental caries among children in the developing world calls for a return to primary health care principles with a focus on prevention. The 'Fit for School' program in the Philippines is based on international recommendations and offers a feasible, low-cost and realistic strategy using the principles of health promotion outlined in the Ottawa Charter. The cornerstone of the programme is the use of school structures for the implementation of preventive health strategies. 'Fit for School' consists of simple, evidence-based interventions like hand washing with soap, tooth brushing with fluoride toothpaste and other high impact interventions such as bi-annual de-worming as a routine school activity for all children visiting public elementary schools. The programme has been successfully rolled-out in the Philippines covering 630,000 children in 22 provinces and it is planned to reach 6 million children in the next three years. The programme is a partnership project between the Philippine Department of Education and the Local Government Units with support for capacity development activities from the German Development Cooperation and GlaxoSmithKline.

  7. Prediction of Pneumococcal Conjugate Vaccine Effectiveness against Invasive Pneumococcal Disease Using Opsonophagocytic Activity and Antibody Concentrations Determined by Enzyme-Linked Immunosorbent Assay with 22F Adsorption ▿

    PubMed Central

    Schuerman, L.; Wysocki, J.; Tejedor, J. C.; Knuf, M.; Kim, K.-H.; Poolman, J.

    2011-01-01

    We compared the abilities of two serological readouts, antipolysaccharide IgG antibody concentrations and opsonophagocytic activity (OPA) titers, to predict the clinical effectiveness of the 7-valent pneumococcal conjugate vaccine (7vCRM) against invasive pneumococcal disease (IPD). We also assessed the accuracy of the previously established thresholds for GlaxoSmithKline's enzyme-linked immunosorbent assay with 22F adsorption (22F-ELISA) (≥0.2 μg/ml) and OPA assay (titer, ≥8) in predicting effectiveness. We showed that following a 3-dose 7vCRM primary vaccination, the serological response rates as determined using thresholds of ≥0.2 μg/ml IgG and an OPA titer of ≥8 corresponded well with overall effectiveness against IPD. In addition, the OPA assay seemed to better predict serotype-specific effectiveness than enzyme-linked immunoassay. Finally, when applied to post-dose-2 immune responses, both thresholds also corresponded well with the overall IPD effectiveness following a 2-dose 7vCRM primary vaccination. These results support the importance of the OPA assay in evaluating immune responses to pneumococcal conjugate vaccines. PMID:21994351

  8. Systematic review of fever, febrile convulsions and serious adverse events following administration of inactivated trivalent influenza vaccines in children.

    PubMed

    Li-Kim-Moy, J; Yin, J K; Rashid, H; Khandaker, G; King, C; Wood, N; Macartney, K K; Jones, C; Booy, R

    2015-06-18

    In 2010, increased febrile convulsions (FC) occurred after administration of inactivated trivalent influenza vaccine (TIV) in Australia. We systematically reviewed the rates of fever, FC and serious adverse events (SAEs) after TIV, focussing on published and unpublished clinical trial data from 2005 to 2012, and performed meta-analysis of fever rates. From 4,372 records in electronic databases, 18 randomised controlled trials (RCTs), 14 non-randomised clinical trials, six observational studies and 12 registered trials (five RCTs and seven non-randomised) were identified. In published RCTs, fever ≥ 38 °C rates after first dose of non-adjuvanted TIV were 6.7% and 6.9% for children aged 6–35 months and ≥ 3 years, respectively. Analysis of RCTs by vaccine manufacturer showed pooled fever estimates up to 5.1% with Sanofi or GlaxoSmithKline vaccines; bioCSL vaccines were used in two non-randomised clinical trials and one unpublished RCT and were associated with fever in 22.5–37.1% for children aged 6–35 months. In RCTs, FCs occurred at a rate of 1.1 per 1,000 vaccinated children. While most TIVs induced acceptably low fever rates, bioCSL influenza vaccines were associated with much higher rates of fever in young children. Future standardised study methodology and access to individual level data would be illuminating.

  9. Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption.

    PubMed

    Cheng, Ziqiang; Zhang, Jinqiang; Liu, Houfu; Li, Yi; Zhao, Yonggang; Yang, Eric

    2010-08-01

    Therapy for central nervous system (CNS) diseases requires drugs that can cross the blood-brain barrier (BBB). BBB disruption has been reported in patients with multiple sclerosis (MS) and Alzheimer's disease (AD) and the related animal models as evidenced by increased infiltration of inflammatory cells or increased staining of Igs in the central nervous system. Although CNS penetration of therapeutic agents under pathological conditions has rarely been investigated, it is commonly assumed that BBB disruption may lead to enhanced CNS penetration and also provide a "window of opportunity" through which drugs that do not normally cross BBB are able to do so. In this article, we have compared brain penetration of eight small molecules in naive animals and experimental autoimmune encephalomyelitis (EAE) mice, streptozotocin-induced mice, and TASTPM transgenic mice. The tool compounds are lipophilic transcellular drugs [GlaxoSmithKline (GSK)-A, GSK-B, GSK-C, and naproxen], lipophilic P-glycoprotein (P-gp) substrates (amprenavir and loperamide), and hydrophilic paracellular compounds (sodium fluorescein and atenolol). Our data showed that rate and extent of CNS penetration for lipophilic transcellular drugs and P-gp substrates are similar in naive and all tested animal models. The brain penetration for paracellular drugs in EAE mice is transiently increased but similar to that in naive mice at steady state. Our data suggest that, despite reported BBB disruption, CNS penetration for small molecule therapeutic agents does not increase in MS- and AD-related animal models.

  10. Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research.

    PubMed

    Lee, Sung Jong; Yang, Andrew; Wu, T C; Hung, Chien Fu

    2016-09-01

    Cervical cancer is the fourth most lethal women's cancer worldwide. Current treatments against cervical cancer include surgery, radiotherapy, chemotherapy, and anti-angiogenic agents. However, despite the various treatments utilized for the treatment of cervical cancer, its disease burden remains a global issue. Persistent infection of human papillomavirus (HPV) has been identified as an essential step of pathogenesis of cervical cancer and many other cancers, and nation-wide HPV screening as well as preventative HPV vaccination program have been introduced globally. However, even though the commercially available prophylactic HPV vaccines, Gardasil (Merck) and Cervarix (GlaxoSmithKline), are effective in blocking the entry of HPV into the epithelium of cervix through generation of HPV-specific neutralizing antibodies, they cannot eliminate the pre-existing HPV infection. For these reason, other immunotherapeutic options against HPV-associated diseases, including therapeutic vaccines, have been continuously explored. Therapeutic HPV vaccines enhance cell-mediated immunity targeting HPV E6 and E7 antigens by modulating primarily dendritic cells and cytotoxic T lymphocyte. Our review will cover various therapeutic vaccines in development for the treatment of HPV-associated lesions and cancers. Furthermore, we will discuss the potential of immune checkpoint inhibitors that have recently been adopted and tested for their treatment efficacy against HPV-induced cervical cancer.

  11. Immunogenicity of Infanrix™ hexa administered at 3, 5 and 11 months of age.

    PubMed

    Van Der Meeren, Olivier; Kuriyakose, Sherine; Kolhe, Devayani; Hardt, Karin

    2012-04-05

    A pooled analysis of data from four vaccination studies conducted in Europe was undertaken to assess the immunogenicity of Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Biologicals) when administered in a total of 702 healthy infants at 3, 5 and 11-12 months of age. One month after dose 2, between 96.3% and 100% of subjects had seroprotective antibodies against diphtheria, tetanus, hepatitis B and poliovirus types 1, 2 and 3; 91.7% against Hib and ≥99.0% were seropositive for each pertussis antigen. One month after the third dose, 98.9-100% of subjects were seroprotected/seropositive for all vaccine antigens. Geometric mean antibody concentrations/titres for each vaccine antigen increased by 6.7-52.9 fold after the third vaccine dose. No serious adverse events in DTPa-HBV-IPV/Hib recipients were vaccine related. Infanrix™ hexa induces an adequate immune response after 2-dose primary plus booster doses when administered according to a 3, 5 and 11 months schedule.

  12. Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b vaccine; Infanrix™ hexa

    PubMed Central

    Baldo, Vincenzo; Bonanni, Paolo; Castro, Marcela; Gabutti, Giovanni; Franco, Elisabetta; Marchetti, Federico; Prato, Rosa; Vitale, Francesco

    2014-01-01

    Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11–12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age, and conducted an analysis of safety using global and Italian post-marketing surveillance data. In Italy, DTPa-HBV-IPV/Hib has a demonstrated safety record extending over a decade of use, it has been associated with record levels of vaccine coverage, and with sustained disease control in vaccinated cohorts. Hexavalent vaccines will continue to contribute to high vaccine coverage in Italy and across Europe. PMID:24004825

  13. Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type B vaccine; Infanrix™ hexa: twelve years of experience in Italy.

    PubMed

    Baldo, Vincenzo; Bonanni, Paolo; Castro, Marcela; Gabutti, Giovanni; Franco, Elisabetta; Marchetti, Federico; Prato, Rosa; Vitale, Francesco

    2014-01-01

    Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11-12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age, and conducted an analysis of safety using global and Italian post-marketing surveillance data. In Italy, DTPa-HBV-IPV/Hib has a demonstrated safety record extending over a decade of use, it has been associated with record levels of vaccine coverage, and with sustained disease control in vaccinated cohorts. Hexavalent vaccines will continue to contribute to high vaccine coverage in Italy and across Europe.

  14. Persistence of T-cell immune response induced by two acellular pertussis vaccines in children five years after primary vaccination.

    PubMed

    Palazzo, Raffaella; Carollo, Maria; Bianco, Manuela; Fedele, Giorgio; Schiavoni, Ilaria; Pandolfi, Elisabetta; Villani, Alberto; Tozzi, Alberto E; Mascart, Françoise; Ausiello, Clara M

    2016-01-01

    The resurgence of pertussis suggests the need for greater efforts to understand the long-lasting protective responses induced by vaccination. In this paper we dissect the persistence of T memory responses induced by primary vaccination with two different acellular pertussis (aP) vaccines, hexavalent Hexavac® vaccine (Hexavac) (Sanofi Pasteur MSD) and Infanrix hexa® (Infanrix) (Glaxo-SmithKline Biologicals). We evaluated magnitude and duration of T-cell responses to pertussis toxin (PT) by measuring T-cell proliferation, cytokines (IL-2 and IFNγ) production and memory subsets in two groups of children 5 years after primary vaccination. Some of the enrolled children received only primary vaccination, while others had the pre-school boost dose. Positive T-cell responses to PT were detected in 36% of children. Percentage of responsive children, T-cell proliferation and CD4IL-2+ cells were significantly higher in the children primed with Hexavac than in those who received Infanrix vaccine. No major effects of the boost on PT-specific proliferation were observed. Overall, our data documented a persistence of T-cell memory against PT in a minor fraction of children 5 years after primary vaccination. The different responses induced by Hexavac and Infanrix vaccine could rely on differences in PT inactivation process or excipients/adjuvants formulations.

  15. Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y tetanus toxoid conjugate vaccine for infants and toddlers.

    PubMed

    Bryant, Kristina A; Marshall, Gary S

    2011-07-01

    The highest rates of invasive meningococcal disease occur in children under 2 years of age, yet as of early 2011 no vaccine was licensed for the youngest infants. However, a novel vaccine consisting of capsular polysaccharides from Haemophilus influenzae type b (Hib) and Neisseria meningitidis serogroups C and Y conjugated to tetanus toxoid (HibMenCY-TT; MenHibrix, GlaxoSmithKline) is in the late stages of development. In clinical trials involving more than 7800 children, HibMenCY-TT was shown to be safe and immunogenic when administered at 2, 4, 6 and 12-15 months of age. Anti-polyribosylribitol phosphate antibody responses were noninferior to those elicited by licensed monovalent Hib vaccines, and most vaccinees developed bactericidal antibodies against N. meningitidis serogroups C and Y. The majority of subjects retained antibody responses as far as 3 years after vaccination. If licensed, HibMenCY-TT not only represents an incremental option for protection against invasive Hib, but also has the potential to prevent invasive meningococcal disease without increasing the number of injections.

  16. Use of MenACWY-CRM vaccine in children aged 2 through 23 months at increased risk for meningococcal disease: recommendations of the Advisory Committee on Immunization Practices, 2013.

    PubMed

    MacNeil, Jessica R; Rubin, Lorry; McNamara, Lucy; Briere, Elizabeth C; Clark, Thomas A; Cohn, Amanda C

    2014-06-20

    During its October 2013 meeting, the Advisory Committee on Immunization Practices (ACIP) recommended use of a third meningococcal conjugate vaccine, MenACWY-CRM (Menveo, Novartis), as an additional option for vaccinating infants aged 2 through 23 months at increased risk for meningococcal disease. MenACWY-CRM is the first quadrivalent meningococcal conjugate vaccine licensed for use in children aged 2 through 8 months. MenACWY-D (Menactra, Sanofi Pasteur) is recommended for use in children aged 9 through 23 months who are at increased risk for meningococcal disease, and Hib-MenCY-TT (MenHibrix, GlaxoSmithKline) is recommended for use in children aged 6 weeks through 18 months at increased risk. This report summarizes information on MenACWY-CRM administration in infants and provides recommendations for vaccine use in infants aged 2 through 23 months who are at increased risk for meningococcal disease. Because the burden of meningococcal disease in infants is low in the United States and the majority of cases that do occur are caused by serogroup B, which is not included in any vaccine licensed in the United States, only those infants who are at increased risk for meningococcal disease are recommended to receive a meningococcal vaccine.

  17. Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.

    PubMed

    Diaz, Rosario; Luengo-Arratta, Sandra A; Seixas, João D; Amata, Emanuele; Devine, William; Cordon-Obras, Carlos; Rojas-Barros, Domingo I; Jimenez, Elena; Ortega, Fatima; Crouch, Sabrinia; Colmenarejo, Gonzalo; Fiandor, Jose Maria; Martin, Jose Julio; Berlanga, Manuela; Gonzalez, Silvia; Manzano, Pilar; Navarro, Miguel; Pollastri, Michael P

    2014-10-01

    In the interest of identification of new kinase-targeting chemotypes for target and pathway analysis and drug discovery in Trypanosomal brucei, a high-throughput screen of 42,444 focused inhibitors from the GlaxoSmithKline screening collection was performed against parasite cell cultures and counter-screened against human hepatocarcinoma (HepG2) cells. In this way, we have identified 797 sub-micromolar inhibitors of T. brucei growth that are at least 100-fold selective over HepG2 cells. Importantly, 242 of these hit compounds acted rapidly in inhibiting cellular growth, 137 showed rapid cidality. A variety of in silico and in vitro physicochemical and drug metabolism properties were assessed, and human kinase selectivity data were obtained, and, based on these data, we prioritized three compounds for pharmacokinetic assessment and demonstrated parasitological cure of a murine bloodstream infection of T. brucei rhodesiense with one of these compounds (NEU-1053). This work represents a successful implementation of a unique industrial-academic collaboration model aimed at identification of high quality inhibitors that will provide the parasitology community with chemical matter that can be utilized to develop kinase-targeting tool compounds. Furthermore these results are expected to provide rich starting points for discovery of kinase-targeting tool compounds for T. brucei, and new HAT therapeutics discovery programs.

  18. Enhanced modified Smith predictor for second-order non-minimum phase unstable processes

    NASA Astrophysics Data System (ADS)

    Uma, S.; Seshagiri Rao, A.

    2016-03-01

    In this paper, a modified Smith predictor design is proposed for enhanced control of non-minimum phase unstable second-order time-delay processes with/without zero. The proposed method involves the design of two controllers, i.e. set-point tracking controller and disturbance rejection controller. Set-point tracking controller is designed as a proportional-integral-derivative (PID) in series with a lag filter using direct synthesis method. The disturbance rejection controller is designed as a PID in series with a lead/lag filter based on direct synthesis method. Set-point weighting is considered for minimising the overshoots. The proposed method is applied by simulation on several second-order unstable processes. Robustness studies have been carried out using the small-gain theorem. The method gives good nominal and robust control performances. Significant improvement in the disturbance rejection is obtained with the proposed method when compared to the recently reported methods in the literature.

  19. Exome analysis of Smith-Magenis-like syndrome cohort identifies de novo likely pathogenic variants.

    PubMed

    Berger, Seth I; Ciccone, Carla; Simon, Karen L; Malicdan, May Christine; Vilboux, Thierry; Billington, Charles; Fischer, Roxanne; Introne, Wendy J; Gropman, Andrea; Blancato, Jan K; Mullikin, James C; Gahl, William A; Huizing, Marjan; Smith, Ann C M

    2017-04-01

    Smith-Magenis syndrome (SMS), a neurodevelopmental disorder characterized by dysmorphic features, intellectual disability (ID), and sleep disturbances, results from a 17p11.2 microdeletion or a mutation in the RAI1 gene. We performed exome sequencing on 6 patients with SMS-like phenotypes but without chromosomal abnormalities or RAI1 variants. We identified pathogenic de novo variants in two cases, a nonsense variant in IQSEC2 and a missense variant in the SAND domain of DEAF1, and candidate de novo missense variants in an additional two cases. One candidate variant was located in an alpha helix of Necdin (NDN), phased to the paternally inherited allele. NDN is maternally imprinted within the 15q11.2 Prader-Willi Syndrome (PWS) region. This can help clarify NDN's role in the PWS phenotype. No definitive pathogenic gene variants were detected in the remaining SMS-like cases, but we report our findings for future comparison. This study provides information about the inheritance pattern and recurrence risk for patients with identified variants and demonstrates clinical and genetic overlap of neurodevelopmental disorders. Identification and characterization of ID-related genes that assist in development of common developmental pathways and/or gene-networks, may inform disease mechanism and treatment strategies.

  20. Ella Thea Smith and the lost history of American high school biology textbooks.

    PubMed

    Ladouceur, Ronald P

    2008-01-01

    Two influential articles published in the 1970s suggested that pressure from Christian fundamentalists, subsequent to the Scopes trial of 1925, forced American high school biology textbook authors and publishers to significantly limit discussion of the topic of evolution. The conclusions reached by these studies have become foundational for historians examining the interplay between science and religion in the United States in the twentieth century. However, a reexamination of key twentieth century biology textbooks suggests that the narrative that the treatment of the theory of evolution was held hostage to anti-rational cultural forces is largely a myth, created first as part of a public relations effort by the Biological Sciences Curriculum Study (BSCS) to differentiate, defend, and promote its work, and later as part of an attempt by scholars to sound a warning concerning the rise of the religious right. A focus on this narrative has not only allowed biologists to sidestep uncomfortable questions regarding the race-biased and class-biased assumptions embedded within the concept of evolutionary progress, it has also limited reliance on the texts in question as reliable reflections of the cultural assumptions of educators and scientists. A reexamination of the most popular American biology textbooks from 1907 to 1963, particularly the work of Ella Thea Smith, provides evidence in support of these contentions.