Discriminability measures for predicting readability of text on textured backgrounds

NASA Technical Reports Server (NTRS)

Scharff, L. F.; Hill, A. L.; Ahumada, A. J. Jr; Watson, A. B. (Principal Investigator)

2000-01-01

Several discriminability measures were examined for their ability to predict reading search times for three levels of text contrast and a range of backgrounds (plain, a periodic texture, and four spatial-frequency-filtered textures created from the periodic texture). Search times indicate that these background variations only affect readability when the text contrast is low, and that spatial frequency content of the background affects readability. These results were not well predicted by the single variables of text contrast (Spearman rank correlation = -0.64) and background RMS contrast (0.08), but a global masking index and a spatial-frequency-selective masking index led to better predictions (-0.84 and -0.81, respectively). c2000 Optical Society of America.

Regional and global modeling estimates of policy relevant background ozone over the United States

NASA Astrophysics Data System (ADS)

Emery, Christopher; Jung, Jaegun; Downey, Nicole; Johnson, Jeremiah; Jimenez, Michele; Yarwood, Greg; Morris, Ralph

2012-02-01

Policy Relevant Background (PRB) ozone, as defined by the US Environmental Protection Agency (EPA), refers to ozone concentrations that would occur in the absence of all North American anthropogenic emissions. PRB enters into the calculation of health risk benefits, and as the US ozone standard approaches background levels, PRB is increasingly important in determining the feasibility and cost of compliance. As PRB is a hypothetical construct, modeling is a necessary tool. Since 2006 EPA has relied on global modeling to establish PRB for their regulatory analyses. Recent assessments with higher resolution global models exhibit improved agreement with remote observations and modest upward shifts in PRB estimates. This paper shifts the paradigm to a regional model (CAMx) run at 12 km resolution, for which North American boundary conditions were provided by a low-resolution version of the GEOS-Chem global model. We conducted a comprehensive model inter-comparison, from which we elucidate differences in predictive performance against ozone observations and differences in temporal and spatial background variability over the US. In general, CAMx performed better in replicating observations at remote monitoring sites, and performance remained better at higher concentrations. While spring and summer mean PRB predicted by GEOS-Chem ranged 20-45 ppb, CAMx predicted PRB ranged 25-50 ppb and reached well over 60 ppb in the west due to event-oriented phenomena such as stratospheric intrusion and wildfires. CAMx showed a higher correlation between modeled PRB and total observed ozone, which is significant for health risk assessments. A case study during April 2006 suggests that stratospheric exchange of ozone is underestimated in both models on an event basis. We conclude that wildfires, lightning NO x and stratospheric intrusions contribute a significant level of uncertainty in estimating PRB, and that PRB will require careful consideration in the ozone standard setting process.

Parallel and competitive processes in hierarchical analysis: perceptual grouping and encoding of closure.

PubMed

Han, S; Humphreys, G W; Chen, L

1999-10-01

The role of perceptual grouping and the encoding of closure of local elements in the processing of hierarchical patterns was studied. Experiments 1 and 2 showed a global advantage over the local level for 2 tasks involving the discrimination of orientation and closure, but there was a local advantage for the closure discrimination task relative to the orientation discrimination task. Experiment 3 showed a local precedence effect for the closure discrimination task when local element grouping was weakened by embedding the stimuli from Experiment 1 in a background made up of cross patterns. Experiments 4A and 4B found that dissimilarity of closure between the local elements of hierarchical stimuli and the background figures could facilitate the grouping of closed local elements and enhanced the perception of global structure. Experiment 5 showed that the advantage for detecting the closure of local elements in hierarchical analysis also held under divided- and selective-attention conditions. Results are consistent with the idea that grouping between local elements takes place in parallel and competes with the computation of closure of local elements in determining the selection between global and local levels of hierarchical patterns for response.

Countdown to Drawdown: an initial overview of exponential scaling of potential societal tipping points for deep decarbonization of global energy infrastructure by 2050

NASA Astrophysics Data System (ADS)

McCaffrey, Mark; Bhowmik, Avit

2017-04-01

The 194 signatories to the Paris Agreement range in size from small island nations (Tuvalu, less than 10,000 people) to massive states (India and China, which between them have 2.6 billion people). Their cultural backgrounds, political, economic and social systems vary widely. What they all share is an agreement for climate stabilisation at 1.5-2˚ C. A roadmap outlining potential exponential transitions towards a carbon-free economy may benefit from a logarithmic "powers of ten" framework that sets aside backgrounds and systems to examine the relative population concentration scales-from the individual (100) to local/neighborhood (103) to the national/transnational scales (108) and ultimately the global population of around 10 billion anticipated in 2050 (1010). What are the related targets and indicators for successful engagement at each level for rapid and radical reductions of carbon emissions and concentrations? What are the possible interventions and barriers that may be applied at different levels of population concentration? What "drawdown" strategies are most appropriate for different scales? Could focusing demonstrations of clean energy and sustainable practices on the local/neighborhood to urban scale (103-104) provide a leverage that has not been achieved at more complex national and transnational scales? Ultimately, backgrounds and systems are important factors in the equation, but the "powers of 10" scaling framework may provide a compass to assist in identifying the challenges, opportunities and related thresholds and tipping points for achieving deep decarbonization and transformation of the global energy infrastructure at every level of society over the next thirty-three years.

The profound reach of the 11 April 2012 M 8.6 Indian Ocean earthquake: Short‐term global triggering followed by a longer‐term global shadow

USGS Publications Warehouse

Pollitz, Fred; Burgmann, Roland; Stein, Ross S.; Sevilgen, Volkan

2014-01-01

The 11 April 2012 M 8.6 Indian Ocean earthquake was an unusually large intraoceanic strike‐slip event. For several days, the global M≥4.5 and M≥6.5 seismicity rate at remote distances (i.e., thousands of kilometers from the mainshock) was elevated. The strike‐slip mainshock appears through its Love waves to have triggered a global burst of strike‐slip aftershocks over several days. But the M≥6.5 rate subsequently dropped to zero for the succeeding 95 days, although the M≤6.0 global rate was close to background during this period. Such an extended period without an M≥6.5 event has happened rarely over the past century, and never after a large mainshock. Quiescent periods following previous large (M≥8) mainshocks over the past century are either much shorter or begin so long after a given mainshock that no physical interpretation is warranted. The 2012 mainshock is unique in terms of both the short‐lived global increase and subsequent long quiescent period. We believe that the two components are linked and interpret this pattern as the product of dynamic stressing of a global system of faults. Transient dynamic stresses can encourage short‐term triggering, but, paradoxically, it can also inhibit rupture temporarily until background tectonic loading restores the system to its premainshock stress levels.

Methyl-Donor and Cofactor Nutrient Intakes in the First 2–3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study

PubMed Central

Taylor, Rachael M.; Smith, Roger; Collins, Clare E.; Mossman, David; Wong-Brown, Michelle W.; Chan, Eng-Cheng; Evans, Tiffany-Jane; Attia, John R.; Smith, Tenele; Butler, Trent

2018-01-01

Background: During the early postnatal period, the impact of nutrition on DNA methylation has not been well studied in humans. The aim was to quantify the relationship between one-carbon metabolism nutrient intake during the first three years of life and global DNA methylation levels at four years. Design: Childhood dietary intake was assessed using infant feeding questionnaires, food frequency questionnaires, 4-day weighed food records and 24-h food records. The dietary records were used to estimate the intake of methionine, folate, vitamins B2, B6 and B12 and choline. The accumulative nutrient intake specific rank from three months to three years of age was used for analysis. Global DNA methylation (%5-methyl cytosines (%5-mC)) was measured in buccal cells at four years of age, using an enzyme-linked immunosorbent assay (ELISA) commercial kit. Linear regression models were used to quantify the statistical relationships. Results: Data were collected from 73 children recruited from the Women and their Children’s Health (WATCH) study. No association was found between one-carbon metabolism nutrient intake and global DNA methylation levels (P 0.05). Global DNA methylation levels in males were significantly higher than in females (median %5-mC: 1.82 vs. 1.03, males and females respectively, (P 0.05)). Conclusion: No association was found between the intake of one-carbon metabolism nutrients during the early postnatal period and global DNA methylation levels at age four years. Higher global DNA methylation levels in males warrants further investigation. PMID:29495543

Observations of Atmospheric Δ14CO2 at the Global and Regional Background Sites in China: Implication for Fossil Fuel CO2 Inputs.

PubMed

Niu, Zhenchuan; Zhou, Weijian; Cheng, Peng; Wu, Shugang; Lu, Xuefeng; Xiong, Xiaohu; Du, Hua; Fu, Yunchong

2016-11-15

Six months to more than one year of atmospheric Δ 14 CO 2 were measured in 2014-2015 at one global background site in Waliguan (WLG) and four regional background sites at Shangdianzi (SDZ), Lin'an (LAN), Longfengshan (LFS) and Luhuitou (LHT), China. The objectives of the study are to document the Δ 14 CO 2 levels at each site and to trace the variations in fossil fuel CO 2 (CO 2ff ) inputs at regional background sites. Δ 14 CO 2 at WLG varied from 7.1 ± 2.9‰ to 32.0 ± 3.2‰ (average 17.1 ± 6.8‰) in 2015, with high values generally in autumn/summer and low values in winter/spring. During the same period, Δ 14 CO 2 values at the regional background sites were found to be significantly (p < 0.05) lower than those at WLG, indicating different levels of CO 2ff inputs at those sites. CO 2ff concentrations at LAN (12.7 ± 9.6 ppm) and SDZ (11.5 ± 8.2 ppm) were significantly (p < 0.05) higher than those at LHT (4.6 ± 4.3 ppm) in 2015. There were no significant (p > 0.05) seasonal differences in CO 2ff concentrations for the regional sites. Regional sources contributed in part to the CO 2ff inputs at LAN and SDZ, while local sources dominated the trend observed at LHT. These data provide a preliminary understanding of atmospheric Δ 14 CO 2 and CO 2ff inputs for a range of Chinese background sites.

SPONGY (SPam ONtoloGY): Email Classification Using Two-Level Dynamic Ontology

PubMed Central

2014-01-01

Email is one of common communication methods between people on the Internet. However, the increase of email misuse/abuse has resulted in an increasing volume of spam emails over recent years. An experimental system has been designed and implemented with the hypothesis that this method would outperform existing techniques, and the experimental results showed that indeed the proposed ontology-based approach improves spam filtering accuracy significantly. In this paper, two levels of ontology spam filters were implemented: a first level global ontology filter and a second level user-customized ontology filter. The use of the global ontology filter showed about 91% of spam filtered, which is comparable with other methods. The user-customized ontology filter was created based on the specific user's background as well as the filtering mechanism used in the global ontology filter creation. The main contributions of the paper are (1) to introduce an ontology-based multilevel filtering technique that uses both a global ontology and an individual filter for each user to increase spam filtering accuracy and (2) to create a spam filter in the form of ontology, which is user-customized, scalable, and modularized, so that it can be embedded to many other systems for better performance. PMID:25254240

SPONGY (SPam ONtoloGY): email classification using two-level dynamic ontology.

PubMed

Youn, Seongwook

2014-01-01

Email is one of common communication methods between people on the Internet. However, the increase of email misuse/abuse has resulted in an increasing volume of spam emails over recent years. An experimental system has been designed and implemented with the hypothesis that this method would outperform existing techniques, and the experimental results showed that indeed the proposed ontology-based approach improves spam filtering accuracy significantly. In this paper, two levels of ontology spam filters were implemented: a first level global ontology filter and a second level user-customized ontology filter. The use of the global ontology filter showed about 91% of spam filtered, which is comparable with other methods. The user-customized ontology filter was created based on the specific user's background as well as the filtering mechanism used in the global ontology filter creation. The main contributions of the paper are (1) to introduce an ontology-based multilevel filtering technique that uses both a global ontology and an individual filter for each user to increase spam filtering accuracy and (2) to create a spam filter in the form of ontology, which is user-customized, scalable, and modularized, so that it can be embedded to many other systems for better performance.

Neocortical dynamics due to axon propagation delays in cortico-cortical fibers: EEG traveling and standing waves with implications for top-down influences on local networks and white matter disease

PubMed Central

Nunez, Paul L.; Srinivasan, Ramesh

2013-01-01

The brain is treated as a nested hierarchical complex system with substantial interactions across spatial scales. Local networks are pictured as embedded within global fields of synaptic action and action potentials. Global fields may act top-down on multiple networks, acting to bind remote networks. Because of scale-dependent properties, experimental electrophysiology requires both local and global models that match observational scales. Multiple local alpha rhythms are embedded in a global alpha rhythm. Global models are outlined in which cm-scale dynamic behaviors result largely from propagation delays in cortico-cortical axons and cortical background excitation level, controlled by neuromodulators on long time scales. The idealized global models ignore the bottom-up influences of local networks on global fields so as to employ relatively simple mathematics. The resulting models are transparently related to several EEG and steady state visually evoked potentials correlated with cognitive states, including estimates of neocortical coherence structure, traveling waves, and standing waves. The global models suggest that global oscillatory behavior of self-sustained (limit-cycle) modes lower than about 20 Hz may easily occur in neocortical/white matter systems provided: Background cortical excitability is sufficiently high; the strength of long cortico-cortical axon systems is sufficiently high; and the bottom-up influence of local networks on the global dynamic field is sufficiently weak. The global models provide "entry points" to more detailed studies of global top-down influences, including binding of weakly connected networks, modulation of gamma oscillations by theta or alpha rhythms, and the effects of white matter deficits. PMID:24505628

A hybrid modeling with data assimilation to evaluate human exposure level

NASA Astrophysics Data System (ADS)

Koo, Y. S.; Cheong, H. K.; Choi, D.; Kim, A. L.; Yun, H. Y.

2015-12-01

Exposure models are designed to better represent human contact with PM (Particulate Matter) and other air pollutants such as CO, SO2, O3, and NO2. The exposure concentrations of the air pollutants to human are determined by global and regional long range transport of global and regional scales from Europe and China as well as local emissions from urban and road vehicle sources. To assess the exposure level in detail, the multiple scale influence from background to local sources should be considered. A hybrid air quality modeling methodology combing a grid-based chemical transport model with a local plume dispersion model was used to provide spatially and temporally resolved air quality concentration for human exposure levels in Korea. In the hybrid modeling approach, concentrations from a grid-based chemical transport model and a local plume dispersion model are added to provide contributions from photochemical interactions, long-range (regional) transport and local-scale dispersion. The CAMx (Comprehensive Air quality Model with Extensions was used for the background concentrations from anthropogenic and natural emissions in East Asia including Korea while the road dispersion by vehicle emission was calculated by CALPUFF model. The total exposure level of the pollutants was finally assessed by summing the background and road contributions. In the hybrid modeling, the data assimilation method based on the optimal interpolation was applied to overcome the discrepancies between the model predicted concentrations and observations. The air quality data from the air quality monitoring stations in Korea. The spatial resolution of the hybrid model was 50m for the Seoul Metropolitan Ares. This example clearly demonstrates that the exposure level could be estimated to the fine scale for the exposure assessment by using the hybrid modeling approach with data assimilation.

Rapid communication: Global-local processing affects recognition of distractor emotional faces.

PubMed

Srinivasan, Narayanan; Gupta, Rashmi

2011-03-01

Recent studies have shown links between happy faces and global, distributed attention as well as sad faces to local, focused attention. Emotions have been shown to affect global-local processing. Given that studies on emotion-cognition interactions have not explored the effect of perceptual processing at different spatial scales on processing stimuli with emotional content, the present study investigated the link between perceptual focus and emotional processing. The study investigated the effects of global-local processing on the recognition of distractor faces with emotional expressions. Participants performed a digit discrimination task with digits at either the global level or the local level presented against a distractor face (happy or sad) as background. The results showed that global processing associated with broad scope of attention facilitates recognition of happy faces, and local processing associated with narrow scope of attention facilitates recognition of sad faces. The novel results of the study provide conclusive evidence for emotion-cognition interactions by demonstrating the effect of perceptual processing on emotional faces. The results along with earlier complementary results on the effect of emotion on global-local processing support a reciprocal relationship between emotional processing and global-local processing. Distractor processing with emotional information also has implications for theories of selective attention.

Global Ocean Integrals and Means, with Trend Implications.

PubMed

Wunsch, Carl

2016-01-01

Understanding the ocean requires determining and explaining global integrals and equivalent average values of temperature (heat), salinity (freshwater and salt content), sea level, energy, and other properties. Attempts to determine means, integrals, and climatologies have been hindered by thinly and poorly distributed historical observations in a system in which both signals and background noise are spatially very inhomogeneous, leading to potentially large temporal bias errors that must be corrected at the 1% level or better. With the exception of the upper ocean in the current altimetric-Argo era, no clear documentation exists on the best methods for estimating means and their changes for quantities such as heat and freshwater at the levels required for anthropogenic signals. Underestimates of trends are as likely as overestimates; for example, recent inferences that multidecadal oceanic heat uptake has been greatly underestimated are plausible. For new or augmented observing systems, calculating the accuracies and precisions of global, multidecadal sampling densities for the full water column is necessary to avoid the irrecoverable loss of scientifically essential information.

National surveillance of 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins/furans in soil in Taiwan.

PubMed

Hsu, Yi-Chyun; Que, Danielle E; Gou, Yan-You; Tsou, Tsui-Chun; Liu, Chung-Kun; Wang, Yen-Ling; Hou, Wen-Che; Lin, Yi-Hsien; Liu, Wen-Yao; Chao, How-Ran; Lee, Wen-Jhy

2018-07-01

In this study, the polychlorinated dibenzo-p-dioxin/furan (PCDD/F) levels in 381 soil samples coming from different background areas (n = 238) and contaminated areas (n = 143) in Taiwan were investigated from 2011 to 2015 using high resolution gas chromatograph/high resolution mass spectrometry (HRGC/HRMS). The contaminated areas showed higher PCDD/F contamination as compared to the background areas (1230 vs 749 pg/g dry weight (dw)); 14.0 vs 6.25 pg WHO 2005 -TEQ/g dw). The lowest levels were recorded in the outlying islands (1.28 pg WHO 2005 -TEQ/g dw). PCDD/F congener distribution profiles in the background and contaminated areas as well as on the islands varied. OCDD was the dominant congener in almost all locations, including the northern background (87.7%) and central contaminated (74.2%) areas. Other dominant species included OCDF and 1,2,3,4,6,7,8-HpCDD. Levels of PCDD/F-TEQs in Taiwanese soils, including the background areas, were higher than in some developing countries and regions with global background levels due to high industrialization except for the contaminated areas. Geographic differences in dioxin-contaminated soils were also shown in this study. Higher soil dioxin-TEQs were observed in locations with high populations and population densities. Despite the limitations, the economic status of Taiwan represented by the annual averaged family income (AAFI) was positively correlated to soil dioxin-TEQs. Copyright © 2018. Published by Elsevier Ltd.

Background contamination by coplanar polychlorinated biphenyls (PCBs) in trace level high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS) analytical procedures.

PubMed

Ferrario, J; Byrne, C; Dupuy, A E

1997-06-01

The addition of the "dioxin-like" polychlorinated biphenyl (PCB) congeners to the assessment of risk associated with the 2,3,7,8-chlorine substituted dioxins and furans has dramatically increased the number of laboratories worldwide that are developing analytical procedures for their detection and quantitation. Most of these procedures are based on established sample preparation and analytical techniques employing high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS), which are used for the analyses of dioxin/furans at low parts-per-trillion (ppt) levels. A significant and widespread problem that arises when using these sample preparation procedures for the analysis of coplanar PCBs is the presence of background levels of these congeners. Industrial processes, urban incineration, leaking electrical transformers, hazardous waste accidents, and improper waste disposal practices have released appreciable quantities of PCBs into the environment. This contamination has resulted in the global distribution of these compounds via the atmosphere and their ubiquitous presence in ambient air. The background presence of these compounds in method blanks must be addressed when determining the exact concentrations of these and other congeners in environmental samples. In this study reliable procedures were developed to accurately define these background levels and assess their variability over the course of the study. The background subtraction procedures developed and employed increase the probability that the values reported accurately represent the concentrations found in the samples and were not biased due to this background contamination.

Background contamination by coplanar polychlorinated biphenyls (PCBs) in trace level high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS) analytical procedures

NASA Technical Reports Server (NTRS)

Ferrario, J.; Byrne, C.; Dupuy, A. E. Jr

1997-01-01

The addition of the "dioxin-like" polychlorinated biphenyl (PCB) congeners to the assessment of risk associated with the 2,3,7,8-chlorine substituted dioxins and furans has dramatically increased the number of laboratories worldwide that are developing analytical procedures for their detection and quantitation. Most of these procedures are based on established sample preparation and analytical techniques employing high resolution gas chromatography/high resolution mass spectrometry (HRGC/HRMS), which are used for the analyses of dioxin/furans at low parts-per-trillion (ppt) levels. A significant and widespread problem that arises when using these sample preparation procedures for the analysis of coplanar PCBs is the presence of background levels of these congeners. Industrial processes, urban incineration, leaking electrical transformers, hazardous waste accidents, and improper waste disposal practices have released appreciable quantities of PCBs into the environment. This contamination has resulted in the global distribution of these compounds via the atmosphere and their ubiquitous presence in ambient air. The background presence of these compounds in method blanks must be addressed when determining the exact concentrations of these and other congeners in environmental samples. In this study reliable procedures were developed to accurately define these background levels and assess their variability over the course of the study. The background subtraction procedures developed and employed increase the probability that the values reported accurately represent the concentrations found in the samples and were not biased due to this background contamination.

The Landscape of Prek-12 Engineering Online Resources for Teachers: Global Trends

ERIC Educational Resources Information Center

Bagiati, Aikaterini; Yoon, So Yoon; Evangelou, Demetra; Magana, Alejandra; Kaloustian, Garene; Zhu, Jiabin

2015-01-01

Background: The newly formed discipline of engineering education is addressing the need to (a) enhance STEM education for precollege students and (b) identify optimum ways to introduce engineering content starting, perhaps, from the early ages. Introducing engineering at the Prekindergarten through 12th grade (PreK-12) education level requires…

Globalization and local response to epidemiological overlap in 21st century Ecuador

PubMed Central

Waters, William F

2006-01-01

Background Third World countries are confronted by a complex overlay of two sets of health problems. Traditional maladies, including communicable diseases, malnutrition, and environmental health hazards coexist with emerging health challenges, including cardiovascular disease, cancer, and increasing levels of obesity. Using Ecuador as an example, this paper proposes a conceptual framework for linking epidemiologic overlap to emerging social structures and processes at the national and global levels. Discussion Epidemiologic trends can be seen as part of broader processes related to globalization, but this does not imply that globalization is a monolithic force that inevitably and uniformly affects nations, communities, and households in the same manner. Rather, characteristics and forms of social organization at the subnational level can shape the way that globalization takes place. Thus, globalization has affected Ecuador in specific ways and is, at the same time, intimately related to the form in which the epidemiologic transition has transpired in that country. Summary Ecuador is among neither the poorest nor the wealthiest countries and its situation may illuminate trends in other parts of the world. As in other countries, insertion into the global economy has not taken place in a vacuum; rather, Ecuador has experienced unprecedented social and demographic change in the past several decades, producing profound transformation in its social structure. Examples of local represent alternatives to centralized health systems that do not effectively address the complex overlay of traditional and emerging health problems. PMID:16712722

Enhanced Global Signal of Neutral Hydrogen Due to Excess Radiation at Cosmic Dawn

NASA Astrophysics Data System (ADS)

Feng, Chang; Holder, Gilbert

2018-05-01

We revisit the global 21 cm signal calculation incorporating a possible radio background at early times, and find that the global 21 cm signal shows a much stronger absorption feature, which could enhance detection prospects for future 21 cm experiments. In light of recent reports of a possible low-frequency excess radio background, we propose that detailed 21 cm calculations should include a possible early radio background.

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma

PubMed Central

2012-01-01

Background The aim of this study was to clarify the role of global hypomethylation of repetitive elements in determining the genetic and clinical features of multiple myeloma (MM). Methods We assessed global methylation levels using four repetitive elements (long interspersed nuclear element-1 (LINE-1), Alu Ya5, Alu Yb8, and Satellite-α) in clinical samples comprising 74 MM samples and 11 benign control samples (7 cases of monoclonal gammopathy of undetermined significance (MGUS) and 4 samples of normal plasma cells (NPC)). We also evaluated copy-number alterations using array-based comparative genomic hybridization, and performed methyl-CpG binding domain sequencing (MBD-seq). Results Global levels of the repetitive-element methylation declined with the degree of malignancy of plasma cells (NPC>MGUS>MM), and there was a significant inverse correlation between the degree of genomic loss and the LINE-1 methylation levels. We identified 80 genomic loci as common breakpoints (CBPs) around commonly lost regions, which were significantly associated with increased LINE-1 densities. MBD-seq analysis revealed that average DNA-methylation levels at the CBP loci and relative methylation levels in regions with higher LINE-1 densities also declined during the development of MM. We confirmed that levels of methylation of the 5' untranslated region of respective LINE-1 loci correlated strongly with global LINE-1 methylation levels. Finally, there was a significant association between LINE-1 hypomethylation and poorer overall survival (hazard ratio 2.8, P = 0.015). Conclusion Global hypomethylation of LINE-1 is associated with the progression of and poorer prognosis for MM, possibly due to frequent copy-number loss. PMID:23259664

Global tropospheric chemistry: A plan for action

NASA Technical Reports Server (NTRS)

1984-01-01

Prompted by an increasing awareness of the influence of human activity on the chemistry of the global troposphere, a panel was formed to (1) assess the requirement for a global study of the chemistry of the troposphere; (2) develop a scientific strategy for a comprehensive plan taking into account the existing and projected programs of the government; (3) assess the requirements of a global study in terms of theoretical knowledge, numerical modeling, instrumentation, observing platforms, ground-level observational techniques, and other related needs; and (4) outline the appropriate sequence and coordination required to achieve the most effective utilization of available resources. Part 1 presents a coordinated national blueprint for scientific investigations of biogeochemical cycles in the global troposphere. part 2 presents much of the background information of the present knowledge and gaps in the understanding of tropospheric chemical cycles and processes from which the proposed program was developed.

Global tropospheric chemistry: A plan for action

NASA Astrophysics Data System (ADS)

1984-10-01

Prompted by an increasing awareness of the influence of human activity on the chemistry of the global troposphere, a panel was formed to (1) assess the requirement for a global study of the chemistry of the troposphere; (2) develop a scientific strategy for a comprehensive plan taking into account the existing and projected programs of the government; (3) assess the requirements of a global study in terms of theoretical knowledge, numerical modeling, instrumentation, observing platforms, ground-level observational techniques, and other related needs; and (4) outline the appropriate sequence and coordination required to achieve the most effective utilization of available resources. Part 1 presents a coordinated national blueprint for scientific investigations of biogeochemical cycles in the global troposphere. part 2 presents much of the background information of the present knowledge and gaps in the understanding of tropospheric chemical cycles and processes from which the proposed program was developed.

Global risk management in type 2 diabetes: blood glucose, blood pressure, and lipids--update on the background of the current guidelines.

PubMed

Clemens, A; Siegel, E; Gallwitz, B

2004-10-01

Diabetes mellitus presents a significant public health burden based on its increased morbidity, mortality, and economic cost. The high comorbidity and prevalence of concomitant diseases like hypertension and dyslipidemia in diabetic patients cause the high risk in developing secondary, cost intensive, and for the patient often disastrous late complications (nephropathy, retinopathy, neuropathy, and cardiovascular disease). Therefore, patients with diabetes mellitus need a global risk management that takes the various individual clinical problems into account. The current global standards of therapy in patients with diabetes mellitus are focused on the control of glycemia, blood pressure, and lipid levels, as well as aspirin therapy and avoiding of smoking. There are a number of guidelines and recommendations to manage these global issues. Our review will summarize current recommendations and consolidate therapeutic goals and treatments that are of vital importance in the global risk management in diabetic patients.

Potential role of CS2 photooxidation in tropospheric sulfur chemistry

NASA Technical Reports Server (NTRS)

Wine, P. H.; Chameides, W. L.; Ravishankara, A. R.

1981-01-01

Absorption cross section measurements and model calculations indicate that CS2 photooxidation may be an important tropospheric sink for the CS2, giving a lifetime on the order of a week or two. If background CS2 levels are 10-20 pptv, then CS2 photooxidation may be an important global source of OCS as well.

Implications of allometric model selection for county-level biomass mapping

Treesearch

Laura Duncanson; Wenli Huang; Kristofer Johnson; Anu Swatantran; Ronald E. McRoberts; Ralph Dubayah

2017-01-01

Background: Carbon accounting in forests remains a large area of uncertainty in the global carbon cycle. Forest aboveground biomass is therefore an attribute of great interest for the forest management community, but the accuracy of aboveground biomass maps depends on the accuracy of the underlying field estimates used to calibrate models. These field estimates depend...

Alcohol Consumption and Factors Associated with Depressive Symptoms among Older Adults in Mainland China

ERIC Educational Resources Information Center

Liu, Yujun; Xie, Yimeng; Brossoie, Nancy; Roberto, Karen A.; Redican, Kerry J.

2017-01-01

Background: High levels of alcohol consumption have been shown to be related to cardiovascular disease, cancer, diabetes, and other chronic disease and is an important variable in the global burden of disease. Purpose: This study explored the relationship between alcohol consumption and depressive symptoms among older Chinese adults in mainland…

The Role of Atmospheric Heating over the South China Sea and Western Pacific Regions in Modulating Asian Summer Climate under the Global Warming Background

NASA Astrophysics Data System (ADS)

He, B.

2015-12-01

Global warming is one of the most significant climate change signals at the earth's surface. However, the responses of monsoon precipitation to global warming show very distinct regional features, especially over the South China Sea (SCS) and surrounding regions during boreal summer. To understand the possible dynamics in these specific regions under the global warming background, the changes in atmospheric latent heating and their possible influences on global climate are investigated by both observational diagnosis and numerical sensitivity simulations. Results indicate that summertime latent heating has intensified in the SCS and western Pacific, accompanied by increased precipitation, cloud cover, lower-tropospheric convergence, and decreased sea level pressure. Sensitivity experiments show that middle and upper tropospheric heating causes an east-west feedback pattern between SCS-western Pacific and South Asia, which strengthens the South Asian High in the upper troposphere and moist convergence in the lower troposphere, consequently forcing a descending motion and adiabatic warming over continental South Asia and leading to a warm and dry climate. When air-sea interaction is considered, the simulation results are overall more similar to observations, and in particular the bias of precipitation over the Indian Ocean simulated by AGCMs has been reduced. The results highlight the important role of latent heating in adjusting the changes in sea surface temperature through atmospheric dynamics.

Conventional Prompt Global Strike and Long Range Ballistic Missiles: Background and Issues

DTIC Science & Technology

2017-02-03

Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues Amy F. Woolf Specialist in Nuclear Weapons Policy...February 3, 2017 Congressional Research Service 7-5700 www.crs.gov R41464 Conventional Prompt Global Strike and Long-Range Ballistic Missiles...Congressional Research Service Summary Conventional prompt global strike (CPGS) weapons would allow the United States to strike targets anywhere

Worldwide measurements of radioxenon background near isotope production facilities, a nuclear power plant and at remote sites: the ‘‘EU/JA-II’’ Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saey, P. R.J.; Ringbom, Anders; Bowyer, Ted W.

The Comprehensive Nuclear-Test-Ban Treaty (CTBT) specifies that radioxenon measurements should be performed at 40 or more stations worldwide within the International Monitoring System (IMS). Measuring radioxenon is one of the principle techniques to detect underground nuclear explosions. Specifically, presence and ratios of different radioxenon isotopes allows determining whether a detection event under consideration originated from a nuclear explosion or a civilian source. However, radioxenon monitoring on a global scale is a novel technology and the global civil background must be characterized sufficiently. This paper lays out a study, based on several unique measurement campaigns, of the worldwide concentrations and sourcesmore » of verification relevant xenon isotopes. It complements the experience already gathered with radioxenon measurements within the CTBT IMS programme and focuses on locations in Belgium, Germany, Kuwait, Thailand and South Africa where very little information was available on ambient xenon levels or interesting sites offered opportunities to learn more about emissions from known sources. The findings corroborate the hypothesis that a few major radioxenon sources contribute in great part to the global radioxenon background. Additionally, the existence of independent sources of 131mXe (the daughter of 131I) has been demonstrated, which has some potential to bias the isotopic signature of signals from nuclear explosions.« less

Complex background suppression using global-local registration strategy for the detection of small-moving target on moving platform

NASA Astrophysics Data System (ADS)

Zou, Tianhao; Zuo, Zhengrong

2018-02-01

Target detection is a very important and basic problem of computer vision and image processing. The most often case we meet in real world is a detection task for a moving-small target on moving platform. The commonly used methods, such as Registration-based suppression, can hardly achieve a desired result. To crack this hard nut, we introduce a Global-local registration based suppression method. Differ from the traditional ones, the proposed Global-local Registration Strategy consider both the global consistency and the local diversity of the background, obtain a better performance than normal background suppression methods. In this paper, we first discussed the features about the small-moving target detection on unstable platform. Then we introduced a new strategy and conducted an experiment to confirm its noisy stability. In the end, we confirmed the background suppression method based on global-local registration strategy has a better perform in moving target detection on moving platform.

Genotype-by-sequencing facilitates genetic mapping of a stem rust resistance locus in Aegilops umbellulata, a wild relative of cultivated wheat

USDA-ARS?s Scientific Manuscript database

Background: Wild relatives of wheat play a significant role in wheat improvement as a source of genetic diversity. Stem rust disease of wheat causes significant yield losses at the global level and stem rust pathogen race TTKSK (Ug99) is virulent to most previously deployed resistance genes. Therefo...

Latent Profiles of Parental Self-Efficacy and Children's Multisource-Evaluated Social Competence

ERIC Educational Resources Information Center

Junttila, Niina; Vauras, Marja

2014-01-01

Background: The interrelation between mothers' parental self-efficacy (PSE) and their school-aged children's well-being has been repeatedly proved. The lack of research in this area situates mainly on the absence of fathers, non-existent family-level studies, the paucity of independent evaluators, and the use of global PSE estimates.…

Do We Produce Enough Fruits and Vegetables to Meet Global Health Need?

PubMed Central

Siegel, Karen R.; Ali, Mohammed K.; Srinivasiah, Adithi; Nugent, Rachel A.; Narayan, K. M. Venkat

2014-01-01

Background Low fruit and vegetable (FV) intake is a leading risk factor for chronic disease globally, but much of the world’s population does not consume the recommended servings of FV daily. It remains unknown whether global supply of FV is sufficient to meet current and growing population needs. We sought to determine whether supply of FV is sufficient to meet current and growing population needs, globally and in individual countries. Methods and Findings We used global data on agricultural production and population size to compare supply of FV in 2009 with population need, globally and in individual countries. We found that the global supply of FV falls, on average, 22% short of population need according to nutrition recommendations (supply:need ratio: 0.78 [Range: 0.05–2.01]). This ratio varies widely by country income level, with a median supply:need ratio of 0.42 and 1.02 in low-income and high-income countries, respectively. A sensitivity analysis accounting for need-side food wastage showed similar insufficiency, to a slightly greater extent (global supply:need ratio: 0.66, varying from 0.37 [low-income countries] to 0.77 [high-income countries]). Using agricultural production and population projections, we also estimated supply and need for FV for 2025 and 2050. Assuming medium fertility and projected growth in agricultural production, the global supply:need ratio for FV increases slightly to 0.81 by 2025 and to 0.88 by 2050, with similar patterns seen across country income levels. In a sensitivity analysis assuming no change from current levels of FV production, the global supply:need ratio for FV decreases to 0.66 by 2025 and to 0.57 by 2050. Conclusion The global nutrition and agricultural communities need to find innovative ways to increase FV production and consumption to meet population health needs, particularly in low-income countries. PMID:25099121

What Can We Learn about Mental Health Needs from Tweets Mentioning Dementia on World Alzheimer’s Day?

PubMed Central

Yoon, Sunmoo

2017-01-01

Background Twitter can address the mental health challenges of dementia care. The aims of this study is to explore the contents and user interactions of tweets mentioning dementia to gain insights for dementia care. Methods We collected 35,260 tweets mentioning Alzheimer’s or dementia on World Alzheimer’s Day, September 21st in 2015. Topic modeling and social network analysis were applied to uncover content and structure of user communication. Results Global users generated keywords related to mental health and care including #psychology and #mental health. There were similarities and differences between the UK and the US in tweet content. The macro-level analysis uncovered substantial public interest on dementia. The meso-level network analysis revealed that top leaders of communities were spiritual organizations and traditional media. Conclusions The application of topic modeling and multi-level network analysis while incorporating visualization techniques can promote a global level understanding regarding public attention, interests, and insights regarding dementia care and mental health. PMID:27803262

Background monitoring and its role in global estimation and forecast of the state of the biosphere.

PubMed

Izrael, Y A

1982-12-01

(1) Scientific grounds and the concept of monitoring as the system for observations, assessment and prediction of man-induced changes in the state of natural environment, the program and aims of the background monitoring were developed by the author in 1972-1980. These questions were discussed in detail at the International Symposium on Global Integrated Monitoring (Riga, U.S.S.R., December, 1978). It should be stressed that along with significant anthropogenic loading on large cities and industrial areas, natural ecosystems covering most of the Earth's territory are also exposed to quite extended, though insignificant anthropogenic effects. This paper proposes to consider the ways of the background information use for the biosphere state assessment and prediction. (2) Classification of objects for monitoring from the point of view of the consequences of the man-made impact, pollution in the first hand, is as follows: - population (public health); - ecosystem elements employed by man whose production is used by population (soil, water bodies, forest, etc.); - biotic elements of ecosystems (without the immediate consumed production); - abiotic constituents of natural ecosystems, considerable components of the biosphere, climatic system. (3) Historically, monitoring in all countries involves the first two spheres. The background monitoring also extends on the next two spheres. It should differentially take into account physical, chemical and biological factors of impacts. Indentification of biological effects is most complex and vital. Human impact at the background level proceeds indirectly through a general (global or regional) deterioration of the state of the biosphere. (4) Gradually the background monitoring is being practiced on a larger and larger scale. It is shown that the long-range atmospheric transport of pollutants in various regions leads to a gradual general increase of all the natural media pollution and to perceptible biological effects (soil and water acidification and resulting disturbances in the composition of soil and water organisms). The levels of the background impact differ. Thus, the background concentrations of a number of anthropogenic pollutants in Central Europe is 10-20 times higher than in Central Asia. (5) The area of priority in the background monitoring of the biosphere pollution has become evident: compounds of sulphur, mercury and their derivatives, organochloride pesticides, some radioactive substances (e.g., krypton-85 in the atmosphere). (6) The World Ocean is practically all contaminated on a global scale. Biological effects of the World Ocean pollution cause special concern. Particularly important consequences, including climate impact, may be caused by disturbances in energy and matter transfer between environmental media (water-air, water-bottom, etc.). The priority of the impact factors can be allocated here as well: oil products, metals, organochloride compounds, polycyclic aromatic hydrocarbons. (7) One of the most effective possibilities of environmental quality control is standardization which consists in elaboration of permissible ecological loadings upon ecosystems and natural media. The approach to ecological standardization differs from that of hygienic control in principle. The objective of ecological standardization is to ensure the integrity of the given ecosystem and natural environment on the whole. (8) Ecological standardization in its turn requires knowledge related to the damage from this or another impact because in such a case there is a possibility to compare ecological standards for the same ecosystem in the case when impacts are of different origin (e.g., different pollutants).

Influence of Blood Lipids on Global Coagulation Test Results

PubMed Central

Kim, Jung-Ah; Kim, Ji-Eun; Song, Sang Hoon

2015-01-01

Background High levels of blood lipids have been associated with high levels of coagulation factors. We investigated whether blood lipids influence the results of global coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin generation assay (TGA). Methods PT, aPTT, and TGA, along with procoagulant and anticoagulant factors, were measured in 488 normal individuals. Vitamin K status was assessed with prothrombin-induced by vitamin K absence-II (PIVKA-II). Results The procoagulant factors II, VII, IX, X, and XI and anticoagulant factors protein C and protein S showed significant correlations with triglyceride, and the procoagulant factors II, V, VII, IX, X, XI, and XII and anticoagulant factors antithrombin and protein C correlated with total cholesterol. There were no correlations of blood lipid levels with PIVKA-II levels. Subjects with high triglyceride levels (≥200 mg/dL) showed shorter PT values than those with lower triglyceride levels. However, aPTT value was not changed in terms of blood lipid levels. In both 1 and 5 pM tissue factor-induced TGAs, subjects in the high-triglyceride or high-cholesterol groups (≥240 mg/dL) had high levels of lag time, time-to-peak, and endogenous thrombin potential. Total cholesterol was a significant determinant of PT and TGA values. Conclusion High blood lipids were related with increased coagulation activity in a normal population. Our findings are expected to help interpret the global coagulation test results in individuals with high lipid levels. PMID:25553275

Maintaining the Background Dust Opacity During Northern Hemisphere Summer Mars Using Wind Stress Based Dust Lifting

NASA Astrophysics Data System (ADS)

Jha, V.; Kahre, M. A.

2017-12-01

The Mars atmosphere has low levels of dust during Northern Hemisphere (NH) spring and summer (the non-dusty season) and increased levels during NH autumn and winter (the dusty season). In the absence of regional or global storms, dust devils and local storms maintain a background minimum dust loading during the non-dusty season. While observational surveys and Global Climate Model (GCM) studies suggest that dust devils are likely to be major contributors to the background haze during NH spring and summer, a complete understanding of the relative contribution of dust devils and local dust storms has not yet been achieved. We present preliminary results from an investigation that focuses on the effects of radiatively active water ice clouds on dust lifting processes during these seasons. Water ice clouds are known to affect atmospheric temperatures directly by absorption and emission of thermal infrared radiation and indirectly through dynamical feedbacks. Our goal is to understand how clouds affect the contribution by local (wind stress) dust storms to the background dust haze during NH spring and summer. The primary tool for this work is the NASA Ames Mars GCM, which contains physical parameterizations for a fully interactive dust cycle. Three simulations that included wind stress dust lifting were executed for a period of 5 Martian years: a case that included no cloud formation, a case that included radiatively inert cloud formation and a case that included radiatively active cloud (RAC) formation. Results show that when radiatively active clouds are included, the clouds in the aphelion cloud belt radiatively heat the atmosphere aloft in the tropics (Figure 1). This heating produces a stronger overturning circulation, which in turn produces an enhanced low-level flow in the Hadley cell return branch. The stronger low-level flow drives higher surface stresses and increased dust lifting in those locations. We examine how realistic these simulated results are by comparing the spatial pattern of predicted wind stress lifting with a catalog of observed local storms. Better agreement is achieved in the radiatively active cloud case. These results suggest that wind stress lifting may contribute more to maintaining the background dust haze during NH spring and summer than what previous studies have shown.

The globalisation strategies of five Asian tobacco companies: An analytical framework

PubMed Central

Lee, Kelley; Eckhardt, Jappe

2017-01-01

ABSTRACT With 30% of the world’s smokers, two million deaths annually from tobacco use, and rising levels of tobacco consumption, the Asian region is recognised as central to the future of global tobacco control. There is less understanding, however, of how Asian tobacco companies with regional and global aspirations are contributing to the global burden of tobacco-related disease and death. This introductory article sets out the background and rationale for this special issue on ‘The Emergence of Asian Tobacco Companies: Implications for Global Health Governance’. The article discusses the core questions to be addressed and presents an analytical framework for assessing the globalisation strategies of Asian tobacco firms. The article also discusses the selection of the five case studies, namely as independent companies in Asia which have demonstrated concerted ambitions to be a major player in the world market. PMID:27884083

The globalisation strategies of five Asian tobacco companies: An analytical framework.

PubMed

Lee, Kelley; Eckhardt, Jappe

2017-03-01

With 30% of the world’s smokers, two million deaths annually from tobacco use, and rising levels of tobacco consumption, the Asian region is recognised as central to the future of global tobacco control. There is less understanding, however, of how Asian tobacco companies with regional and global aspirations are contributing to the global burden of tobacco-related disease and death. This introductory article sets out the background and rationale for this special issue on ‘The Emergence of Asian Tobacco Companies: Implications for Global Health Governance’. The article discusses the core questions to be addressed and presents an analytical framework for assessing the globalisation strategies of Asian tobacco firms. The article also discusses the selection of the five case studies, namely as independent companies in Asia which have demonstrated concerted ambitions to be a major player in the world market.

Mercury concentrations in urine of amerindian populations near oil fields in the peruvian and ecuadorian amazon

DOE Office of Scientific and Technical Information (OSTI.GOV)

Webb, Jena, E-mail: jena.webb@mail.mcgill.ca

Background: Mercury is a global contaminant with toxic, persistent effects on human health. Petroleum extraction is an important source of elemental mercury; little is known about human exposure levels near oil fields in the Amazon basin. Objectives: To characterize mercury levels in people living near oil production sites in the Peruvian and Ecuadorian Amazon, controlling for fish consumption, occupation, source of water and socio-demographic characteristics. Methods: Analyze mercury levels in urine samples using cold vapour atomic fluorescence spectrometry from 76 indigenous men and women in eight riverine communities situated near oil wells or pipelines. Subjects answered a questionnaire soliciting socio-demographic,more » occupational and dietary information. Data were analyzed using multiple linear regression modeling. Results: The mean value of U-Hg was 2.61 μg/g creatinine (95% CI: 2.14–3.08), with 7% of the sample recording values above the global background standard suggested by The World Health Organization (5 μg/g creatinine). Women who used water from a surface source had two and a half times the amount of mercury in their urine (mean=3.70 μg/g creatinine, 95% CI: 2.26–5.15) compared with women who used other water sources (mean =1.39 μg/g creatinine, 95% CI: 0.51–2.25). Men who were involved in an oil clean-up operation had twice as much mercury in their urine (mean =3.07 μg/g creatinine, 95% CI: 1.97–4.16) as did those who worked on other tasks (mean =1.56 μg/g creatinine, 95% CI: 1.48–2.65). Mercury levels were not associated with the number of fish meals per week. Conclusions: Indigenous peoples of the Peruvian and Ecuadorian Amazon living near oil production sites generally had urine mercury levels within the global background standard suggested by the World Health Organization. Increased levels of mercury in urine were detected for men involved in oil spill remediation and for women who relied on surface water for household needs. These findings signal the need for strict safety measures to limit the amount of oil entering the waterways in Andean Amazonia so as to protect the health of indigenous people. - Highlights: • 7% of participants had levels of inorganic mercury at or exceeding levels suggested by WHO (5 μg/g creatinine). • U-Hg levels were 2.5 times higher among women using surface water than those who drew on water from a well, spring or rain. • Men who had worked cleaning up an oil spill had more than twice the amount of mercury in their urine as men who did not.« less

Re-Imagining Otherness: An Exploration of the Global Imaginaries of Children from Immigrant Backgrounds in Primary Schools in France and England

ERIC Educational Resources Information Center

Welply, Oakleigh

2015-01-01

This article examines the role of global representations in immigrant-background children's social imaginaries in primary schools in France and England. Increased globalisation, mobility and migration hold strong implications in terms of identity and belonging for children from immigrant backgrounds in schools in European countries, based on…

Clinical observation, pharmacotherapy and referral on discharge of patients with anxiety disorder in a psychiatric emergency service.

PubMed

Pailhez, Guillem; Majó, Albert; Córcoles, David; Ginés, José M; Arcega, José M; Castaño, Juan; Merino, Ana; Bulbena, Antonio; Pérez, Víctor

2015-01-01

To analyze factors associated with clinical observation, pharmacotherapy and referral on discharge of patients with anxiety disorder (AD) seeking care at a psychiatric emergency unit. A total of 5003 consecutive visits were reviewed over a three-year period at a psychiatric emergency service in a tertiary university hospital. Data collected included sociodemographic and clinical information as well as the Global Assessment of Functioning (GAF) and the Severity Psychiatric Illness (SPI) scale scores. Of all the visits, 992 (19.8%) were diagnosed of AD. Of these, 19.6% required clinical observation and 72.2% were referred to a psychiatrist at discharge. Regression analysis showed that referral to psychiatry was associated with being male, native, psychiatric background, greater severity, lower global functioning, and behavioral disorders. Clinical observation (in a box) was associated with being female, greater severity, and psychotic or behavioral symptoms. Prescription of benzodiazepines was associated with anxiety, no history of addiction, and lower global functioning. Antidepressants were associated with being a native, anxiety with no history of addiction, and lower functioning. Antipsychotics were associated with being native, psychiatric background (not addiction), anxiety, and lower functioning. Behavior, psychiatric background and illness severity were determinants of referral to a specialist. Besides these, psychotic symptoms and non-specific clinical symptoms were determinants of observation. Drug prescription in AD is less frequent if the main complaint is not anxiety and depends more on the level of functioning than on that of severity.

The Dynamics among Non-English Speaking Online Learners' Language Proficiency, Coping Mechanisms, and Cultural Intelligence: Implications for Effective Practice for Online Cross-Cultural Collaboration

ERIC Educational Resources Information Center

Ou, Chun-Ming

2012-01-01

Cross-cultural online collaboration has evolved as an inevitable trend that people influenced by globalization cannot neglect. The primary purpose of this study was to discover major factors contributing to productive and effective online cross-cultural collaborative learning for people from diverse cultural backgrounds with varying levels of…

Gene mutations in Mycobacterium tuberculosis: multidrug-resistant TB as an emerging global public health crisis.

PubMed

Mishra, Rahul; Shukla, Priyanka; Huang, Wei; Hu, Ning

2015-01-01

Against a constant background of established infections, epidemics of new and old infectious diseases periodically emerge, greatly magnifying the global burden of infections. TB poses formidable challenges to the global health at the public health and scientific level by acquiring gene mutation into anti TB drugs specially rifampin and isoniazid which leads resistant to drug regime and treatment forms. Our tools to combat MDR (multidrug resistant) TB are dangerously out of date and ineffective. Besides new tools (TB drugs, vaccines, diagnostics), we also need new strategies to identify key Mycobacterium tuberculosis and human host interaction. It is all equally important that we build up high quality clinical trial capacity and bio banks for TB biomarkers identification. But most important is global commitment at all levels to roll back TB before it expose us again. Rapid development of drug resistance caused by M. tuberculosis has lead to measure resistance accurately and easily. This knowledge will certainly help us to understand how to prevent the occurrence of drug resistance as well as identifying genes associated with new drug resistance. Copyright © 2014 Elsevier Ltd. All rights reserved.

Changes in the levels and variability of halocarbons and the compliance with the Montreal Protocol from an urban view.

PubMed

Ou-Yang, Chang-Feng; Chang, Chih-Chung; Chen, Shen-Po; Chew, Clock; Lee, Bo-Ru; Chang, Chih-Yuan; Montzka, Stephen A; Dutton, Geoffrey S; Butler, James H; Elkins, James W; Wang, Jia-Lin

2015-11-01

Ambient levels and variability of major atmospheric halocarbons, i.e. CFC-12, CFC-11, CFC-113, CCl4, CH3CCl3, C2HCl3, and C2Cl4 in a major metropolis (Taipei, Taiwan) were re-investigated after fourteen years by flask sampling in 2012. Our data indicates that the variability expressed as standard deviations (SD) of CFC-113 and CCl4 remained small (2.0 ppt and 1.9 ppt, respectively) for the 10th-90th percentile range in both sampling periods; whereas the variability of CFC-12, CFC-11, C2HCl3, and C2Cl4 measured in 2012 became noticeably smaller than observed in 1998, suggesting their emissions were reduced over time. By comparing with the background data of a global network (NOAA/ESRL/GMD baseline observatories), the ambient levels and distribution of these major halocarbons in Taipei approximated those at a background site (Mauna Loa) in 2012, suggesting that the fingerprint of the major halocarbons in a used-to-be prominent source area has gradually approached to that of the background atmosphere. Copyright © 2015 Elsevier Ltd. All rights reserved.

Iodine-129 measurements in soil samples from Dolon village near the Semipalatinsk nuclear test site.

PubMed

Endo, Satoru; Tomita, Junpei; Tanaka, Kenichi; Yamamoto, Masayoshi; Fukutani, Satoshi; Imanaka, Tetsuji; Sakaguchi, Aya; Amano, Hikaru; Kawamura, Hidehisa; Kawamura, Hisao; Apsalikov, Kazbek N; Gusev, Boris I; Whitehead, Neil E; Shinkarev, Sergey; Hoshi, Masaharu

2008-07-01

Dolon village, located about 60 km from the border of the Semipalatinsk nuclear test site, is known to be heavily contaminated by the first USSR atomic bomb test in August 1949. Soil samples around Dolon were taken in October 2005 in an attempt to evaluate internal thyroid dose arising from incorporation of radioiodine isotopes (mainly (131)I). Iodine-129 in soil was measured by using the technique of accelerator mass spectrometry. The (129)I/(127)I atom ratios measured were in the range from 3.3 x 10(-9) to 3.3 x 10(-7). These values were within the range of the current background level ( approximately 10(-9) to 10(-7)) in the environment, including contributions from the global fallout of atmospheric nuclear tests and local fallout of nuclear facilities. The (129)I atom accumulated level in soil ranged from 1.28 x 10(13) to 1.59 x 10(14) atoms m(-2), the average (8.0 x 10(13)) of which was higher than the background level of (2-5) x 10(13). From the relationship between (129)I and( 137)Cs (corrected for background and decay from 1949 to 2005) accumulated levels, the background level of (129)I and the (129)I/(137)Cs ratio around Dolon were estimated to be (6.4 +/- 0.4) x 10(13) atoms m(-2) and 0.25 +/- 0.16, respectively. This (129)I/(137)Cs ratio is almost similar to the fission yield ratio for (239)Pu fast fission (0.24).

A Decadal Regional and Global Trend Analysis of the Aerosol Optical Depth using a Data-Assimilation Grade Over-Water MODIS and Level 2 MISR Aerosol Products

DTIC Science & Technology

2010-01-01

and seasonal sensitivities to clear sky fraction and emissions (e.g., see annual state of the climate summaries in the BAMS, http://www.ncdc.noaa...gov/bams- state - of - the - climate /). Long term changes are as- sumed to be attributable to more background changes of en- ergy use and economic development

Knowledge and Adherence to Medications among Palestinian Geriatrics Living with Chronic Diseases in the West Bank and East Jerusalem

PubMed Central

Najjar, Anas; Amro, Yazan; Kitaneh, Islam; Abu-Sharar, Salam; Sawalha, Maryam; Jamous, Abrar; Qiq, Muhannad; Makharzeh, Enas; Subb Laban, Bayan; Amro, Wafa; Amro, Ahmad

2015-01-01

Background Adequate patient knowledge about medications is essential for appropriate drug taking behavior and patient adherence. This study aims to assess and quantify the level of knowledge and adherence to medications among Palestinian geriatrics living with chronic diseases and to investigate possible associated socio-demographic characteristics. Methods and Findings We conducted a cross-sectional study during June 2013 and January 2014 among Palestinian geriatrics ≥60 years old living with chronic disease in the West Bank and East Jerusalem. A stratified random sample was selected and a questionnaire-assisted interview was applied for data collection. T-test was applied for bivariate analyzing and one-way ANOVA test was applied for multivariate analyses. Results A total of 1192 Palestinian geriatrics were studied. The average age was 70.3 (SD=8.58) years and ranged from 60-110 years. The sample comprised 659 (55.3%) females and 533 (44.7%) males. The global knowledge and global adherence scores were (67.57%) and (89.29%), respectively. Adequate levels of knowledge were 71.4%, and of adherence 75%, which were recorded for 705 (59.1%) and 1088 (91.3%) participants, respectively. Significant higher levels of global knowledge and global adherence were recorded for males, and for participants who hold a Bachelor’s degree, those who live on their own, and did physical activity for more than 40 hours/week (p-value <0.05). Furthermore, workers, participants with a higher monthly income, and non-smokers have a higher knowledge level with (p-value <0.05). We found positive correlation between participants’ global adherence and global knowledge (r=0.487 and p-value <0.001). Negative correlation was found between participants’ global knowledge and adherence with age (r= -0.236, p-value <0.001 and r= -0.211 and p-value <0.001, respectively. Negative correlation between global knowledge and the number of drugs taken (r= -0.130, p-value <0.001) was predicted. Conclusion We concluded that patients with a higher level of knowledge are more adherent to their medications and that better understanding of socio-demographic factors has a clear influence on the level of knowledge and adherence to medications and thus contributes to the development of guidelines for treatment and may consequently lead to favourable clinical outcomes and savings of health care costs. PMID:26046771

Evaluation of the impact of reducing national emissions of SO2 and metals in Poland on background pollution using a bioindication method

PubMed Central

Gozdowski, Dariusz; Baczewska-Dąbrowska, Aneta H.; Dąbrowski, Piotr; Gworek, Barbara; Suwara, Irena

2018-01-01

Changes in environmental pollution by S, Cd, Cu, Pb and Zn in 2006–2014 were evaluated using a bioindication method. This method was based on measurements of pollutants in Scots pine (Pinus sylvestris L.) needles. The measurements were performed in the Chojnowskie Forests, a region recognized as a background area for central Poland. The changes in the contents of sulfur (S) and metals in needles were not comparable with the changes in the global emissions of the pollutants in Poland. On average, the pollution level in the study area decreased by 9.9% for S, 61.4% for Pb, 22.5% for Cd, 11.7% for Zn and 10.4% for Cu. During the same period, global emissions in Poland decreased by 38.1% for S, 8.0% for Pb, 63.2% for Cd, 11.7% for Zn and 14.0% for Cu. Therefore, the differences in the changes in emissions and the needle contents of each element should be examined separately which was not a goal of this study. However, the discrepancy between these results did not prevent the use of bioindication methods. Evaluation of pollutant contents in plants reflected their incorporation in biological processes rather than air or soil pollution levels. PMID:29474417

Evaluation of the impact of reducing national emissions of SO2 and metals in Poland on background pollution using a bioindication method.

PubMed

Dmuchowski, Wojciech; Gozdowski, Dariusz; Baczewska-Dąbrowska, Aneta H; Dąbrowski, Piotr; Gworek, Barbara; Suwara, Irena

2018-01-01

Changes in environmental pollution by S, Cd, Cu, Pb and Zn in 2006-2014 were evaluated using a bioindication method. This method was based on measurements of pollutants in Scots pine (Pinus sylvestris L.) needles. The measurements were performed in the Chojnowskie Forests, a region recognized as a background area for central Poland. The changes in the contents of sulfur (S) and metals in needles were not comparable with the changes in the global emissions of the pollutants in Poland. On average, the pollution level in the study area decreased by 9.9% for S, 61.4% for Pb, 22.5% for Cd, 11.7% for Zn and 10.4% for Cu. During the same period, global emissions in Poland decreased by 38.1% for S, 8.0% for Pb, 63.2% for Cd, 11.7% for Zn and 14.0% for Cu. Therefore, the differences in the changes in emissions and the needle contents of each element should be examined separately which was not a goal of this study. However, the discrepancy between these results did not prevent the use of bioindication methods. Evaluation of pollutant contents in plants reflected their incorporation in biological processes rather than air or soil pollution levels.

UN resolution on the prevention and control of non-communicable diseases: an opportunity for global action.

PubMed

Mamudu, Hadii M; Yang, Joshua S; Novotny, Thomas E

2011-01-01

In May 2010, the United Nations (UN) General Assembly unanimously adopted a resolution on non-communicable diseases (NCDs) that called for high-level meetings to address the global burden of NCDs. This paper highlights the growing global burden of NCDs (cardiovascular diseases, cancer, chronic obstructive pulmonary diseases and diabetes), provides a brief historical background on the adoption of the UN NCDs resolution and argues that the resolution provides a remarkable new opportunity for improved international collaboration to address NCDs. Additionally, the paper argues that while the existing World Health Organisation programme on NCDs be continued and expanded, the UN can provide the expanded political leadership that is necessary for multi-sectoral collaboration and can serve as a respected forum for dealing with the issue across numerous key UN agencies.

US medical specialty global health training and the global burden of disease

PubMed Central

Kerry, Vanessa B.; Walensky, Rochelle P.; Tsai, Alexander C.; Bergmark, Regan W.; Bergmark, Brian A.; Rouse, Chaturia; Bangsberg, David R.

2013-01-01

Background Rapid growth in global health activity among US medical specialty education programs has lead to heterogeneity in types of activities and global health training models. The breadth and scope of this activity is not well chronicled. Methods Using a standardized search protocol, we examined the characteristics of US medical residency global health programs by number of programs, clinical specialty, nature of activity (elective, research, extended curriculum based field training), and geographic location across seven different clinical medical residency education specialties. We tabulated programmatic activity by clinical discipline, region and country. We calculated the Spearman's rank correlation coefficient to estimate the association between programmatic activity and country–level disease burden. Results Of the 1856 programs assessed between January and June 2011, there were 380 global health residency training programs (20%) working in 141 countries. 529 individual programmatic activities (elective–based rotations, research programs, extended curriculum–based field training, or other) occurred at 1337 specific sites. The majority of the activities consisted of elective–based rotations. At the country level, disease burden had a statistically significant association with programmatic activity (Spearman's ρ = 0.17) but only explained 3% of the total variation between countries. Conclusions There were a substantial number of US medical specialty global health programs, but a relative paucity of surgical and mental health programs. Elective–based programs were more common than programs that offer longitudinal experiences. Despite heterogeneity, there was a small but statistically significant association between program location and the global burden of disease. Areas for further study include the degree to which US–based programs develop partnerships with their program sites, the significance of this activity for training, and number and breadth of programs in medical specialty global health education in other countries around the world. PMID:24363924

High T3, Low T4 Serum Levels in Mct8 Deficiency Are Not Caused by Increased Hepatic Conversion through Type I Deiodinase

PubMed Central

Wirth, Eva K.; Rijntjes, Eddy; Meyer, Franziska; Köhrle, Josef; Schweizer, Ulrich

2015-01-01

Background The Allan-Herndon-Dudley syndrome is a severe psychomotor retardation accompanied by specific changes in circulating thyroid hormone levels (high T3, low T4). These are caused by mutations in the thyroid hormone transmembrane transport protein monocarboxylate transporter 8 (MCT8). Objective: To test the hypothesis that circulating low T4 and high T3 levels are caused by enhanced conversion of T4 via increased activity of hepatic type I deiodinase (Dio1). Methods We crossed mice deficient in Mct8 with mice lacking Dio1 activity in hepatocytes. Translation of the selenoenzyme Dio1 was abrogated by hepatocyte-specific inactivation of selenoprotein biosynthesis. Results Inactivation of Dio1 activity in the livers of global Mct8-deficient mice does not restore normal circulating thyroid hormone levels. Conclusions Our data suggest that although hepatic Dio1 activity is increased in Mct8-deficient mice, it does not cause the observed abnormal circulating thyroid hormone levels. Since global inactivation of Dio1 in Mct8-deficient mice does normalize circulating thyroid hormone levels, the underlying mechanism and relevant tissues involved remain to be elucidated. PMID:26601078

Variational dynamic background model for keyword spotting in handwritten documents

NASA Astrophysics Data System (ADS)

Kumar, Gaurav; Wshah, Safwan; Govindaraju, Venu

2013-12-01

We propose a bayesian framework for keyword spotting in handwritten documents. This work is an extension to our previous work where we proposed dynamic background model, DBM for keyword spotting that takes into account the local character level scores and global word level scores to learn a logistic regression classifier to separate keywords from non-keywords. In this work, we add a bayesian layer on top of the DBM called the variational dynamic background model, VDBM. The logistic regression classifier uses the sigmoid function to separate keywords from non-keywords. The sigmoid function being neither convex nor concave, exact inference of VDBM becomes intractable. An expectation maximization step is proposed to do approximate inference. The advantage of VDBM over the DBM is multi-fold. Firstly, being bayesian, it prevents over-fitting of data. Secondly, it provides better modeling of data and an improved prediction of unseen data. VDBM is evaluated on the IAM dataset and the results prove that it outperforms our prior work and other state of the art line based word spotting system.

Background derivation and image flattening: getimages

NASA Astrophysics Data System (ADS)

Men'shchikov, A.

2017-11-01

Modern high-resolution images obtained with space observatories display extremely strong intensity variations across images on all spatial scales. Source extraction in such images with methods based on global thresholding may bring unacceptably large numbers of spurious sources in bright areas while failing to detect sources in low-background or low-noise areas. It would be highly beneficial to subtract background and equalize the levels of small-scale fluctuations in the images before extracting sources or filaments. This paper describes getimages, a new method of background derivation and image flattening. It is based on median filtering with sliding windows that correspond to a range of spatial scales from the observational beam size up to a maximum structure width Xλ. The latter is a single free parameter of getimages that can be evaluated manually from the observed image ℐλ. The median filtering algorithm provides a background image \\tilde{Bλ} for structures of all widths below Xλ. The same median filtering procedure applied to an image of standard deviations 𝓓λ derived from a background-subtracted image \\tilde{Sλ} results in a flattening image \\tilde{Fλ}. Finally, a flattened detection image I{λD} = \\tilde{Sλ}/\\tilde{Fλ} is computed, whose standard deviations are uniform outside sources and filaments. Detecting sources in such greatly simplified images results in much cleaner extractions that are more complete and reliable. As a bonus, getimages reduces various observational and map-making artifacts and equalizes noise levels between independent tiles of mosaicked images.

Probabilistic 21st and 22nd Century Sea-Level Projections at a Global Network of Tide-Gauge Sites

NASA Technical Reports Server (NTRS)

Kopp, Robert E.; Horton, Radley M.; Little, Christopher M.; Mitrovica, Jerry X.; Oppenheimer, Michael; Rasmussen, D. J.; Strauss, Benjamin H.; Tebaldi, Claudia

2014-01-01

Sea-level rise due to both climate change and non-climatic factors threatens coastal settlements, infrastructure, and ecosystems. Projections of mean global sea-level (GSL) rise provide insufficient information to plan adaptive responses; local decisions require local projections that accommodate different risk tolerances and time frames and that can be linked to storm surge projections. Here we present a global set of local sea-level (LSL) projections to inform decisions on timescales ranging from the coming decades through the 22nd century. We provide complete probability distributions, informed by a combination of expert community assessment, expert elicitation, and process modeling. Between the years 2000 and 2100, we project a very likely (90% probability) GSL rise of 0.5–1.2?m under representative concentration pathway (RCP) 8.5, 0.4–0.9?m under RCP 4.5, and 0.3–0.8?m under RCP 2.6. Site-to-site differences in LSL projections are due to varying non-climatic background uplift or subsidence, oceanographic effects, and spatially variable responses of the geoid and the lithosphere to shrinking land ice. The Antarctic ice sheet (AIS) constitutes a growing share of variance in GSL and LSL projections. In the global average and at many locations, it is the dominant source of variance in late 21st century projections, though at some sites oceanographic processes contribute the largest share throughout the century. LSL rise dramatically reshapes flood risk, greatly increasing the expected number of “1-in-10” and “1-in-100” year events.

Motor Function Is Associated With Incident Disability in Older African Americans

PubMed Central

Wilson, Robert S.; Yu, Lei; Boyle, Patricia A.; Bennett, David A.; Barnes, Lisa L.

2016-01-01

Background: Disability in older African American adults is common, but its basis is unclear. We tested the hypothesis that the level of motor function is associated with incident disability in older African Americans after adjusting for cognition. Methods: A prospective observational cohort study of 605 older community-dwelling African American adults without dementia was carried out. Baseline global motor score summarized 11 motor performances, cognition was based on 19 cognitive tests, and self-reported disability was obtained annually. We examined the association of motor function with incident disability (instrumental activities of daily living [IADL], activities of daily living [ADL], and mobility disability) with a series of Cox proportional hazards models which controlled for age, sex, and education. Results: Average follow-up was about 5 years. In proportional hazards models, a 1-SD increase in baseline level of global motor score was associated with about a 50% decrease in the risk of subsequent IADL, ADL, and mobility disability (all p values < .001). These associations were unchanged in analyses controlling for cognition and other covariates. Further, the association of global motor score and incident ADL disability varied with the level of cognition (estimate −5.541, SE 1.634, p < .001), such that higher motor function was more protective at higher levels of cognition. Mobility and dexterity components of global motor score were more strongly associated with incident disability than strength (all p values < .001). Conclusions: Better motor function in older African Americans is associated with a decreased risk of developing disability. Moreover, the association of motor function and disability is stronger in individuals with better cognitive function. PMID:26525087

Probabilistic 21st and 22nd century sea-level projections at a global network of tide-gauge sites

NASA Astrophysics Data System (ADS)

Kopp, Robert E.; Horton, Radley M.; Little, Christopher M.; Mitrovica, Jerry X.; Oppenheimer, Michael; Rasmussen, D. J.; Strauss, Benjamin H.; Tebaldi, Claudia

2014-08-01

Sea-level rise due to both climate change and non-climatic factors threatens coastal settlements, infrastructure, and ecosystems. Projections of mean global sea-level (GSL) rise provide insufficient information to plan adaptive responses; local decisions require local projections that accommodate different risk tolerances and time frames and that can be linked to storm surge projections. Here we present a global set of local sea-level (LSL) projections to inform decisions on timescales ranging from the coming decades through the 22nd century. We provide complete probability distributions, informed by a combination of expert community assessment, expert elicitation, and process modeling. Between the years 2000 and 2100, we project a very likely (90% probability) GSL rise of 0.5-1.2 m under representative concentration pathway (RCP) 8.5, 0.4-0.9 m under RCP 4.5, and 0.3-0.8 m under RCP 2.6. Site-to-site differences in LSL projections are due to varying non-climatic background uplift or subsidence, oceanographic effects, and spatially variable responses of the geoid and the lithosphere to shrinking land ice. The Antarctic ice sheet (AIS) constitutes a growing share of variance in GSL and LSL projections. In the global average and at many locations, it is the dominant source of variance in late 21st century projections, though at some sites oceanographic processes contribute the largest share throughout the century. LSL rise dramatically reshapes flood risk, greatly increasing the expected number of "1-in-10" and "1-in-100" year events.

Reflection on Multicultural Education under the Background of Globalization

ERIC Educational Resources Information Center

Geng, Lihua

2013-01-01

As one of the development trends in world education, multicultural education has been confronted with a lot of difficulties in the globalization tide that becomes more and more open. On the basis of making an analysis of the background and connotation of generation of multicultural education, this paper reflects on multicultural education in…

Exploring Effects of Background Context Familiarity and Signaling on Comprehension, Recall, and Cognitive Load

ERIC Educational Resources Information Center

Song, Minjung; Bruning, Roger

2016-01-01

This study was designed to explore the effects of different geographical background contexts and signalling for information about global warming on comprehension, recall and cognitive load. Two different geographical contexts, US and Korean, were employed to frame explanations of global warming phenomena to US students. Two signalling conditions…

A spatiotemporal land-use regression model of winter fine particulate levels in residential neighbourhoods.

PubMed

Smargiassi, Audrey; Brand, Allan; Fournier, Michel; Tessier, François; Goudreau, Sophie; Rousseau, Jacques; Benjamin, Mario

2012-07-01

Residential wood burning can be a significant wintertime source of ambient fine particles in urban and suburban areas. We developed a statistical model to predict minute (min) levels of particles with median diameter of <1 μm (PM1) from mobile monitoring on evenings of winter weekends at different residential locations in Quebec, Canada, considering wood burning emissions. The 6 s PM1 levels were concurrently measured on 10 preselected routes travelled 3 to 24 times during the winters of 2008-2009 and 2009-2010 by vehicles equipped with a GRIMM or a dataRAM sampler and a Global Positioning System device. Route-specific and global land-use regression (LUR) models were developed using the following spatial and temporal covariates to predict 1-min-averaged PM1 levels: chimney density from property assessment data at sampling locations, PM2.5 "regional background" levels of particles with median diameter of <2.5 μm (PM2.5) and temperature and wind speed at hour of sampling, elevation at sampling locations and day of the week. In the various routes travelled, between 49% and 94% of the variability in PM1 levels was explained by the selected covariates. The effect of chimney density was not negligible in "cottage areas." The R(2) for the global model including all routes was 0.40. This LUR is the first to predict PM1 levels in both space and time with consideration of the effects of wood burning emissions. We show that the influence of chimney density, a proxy for wood burning emissions, varies by regions and that a global model cannot be used to predict PM in regions that were not measured. Future work should consider using both survey data on wood burning intensity and information from numerical air quality forecast models, in LUR models, to improve the generalisation of the prediction of fine particulate levels.

Promoting health equity: WHO health inequality monitoring at global and national levels

PubMed Central

Hosseinpoor, Ahmad Reza; Bergen, Nicole; Schlotheuber, Anne

2015-01-01

Background Health equity is a priority in the post-2015 sustainable development agenda and other major health initiatives. The World Health Organization (WHO) has a history of promoting actions to achieve equity in health, including efforts to encourage the practice of health inequality monitoring. Health inequality monitoring systems use disaggregated data to identify disadvantaged subgroups within populations and inform equity-oriented health policies, programs, and practices. Objective This paper provides an overview of a number of recent and current WHO initiatives related to health inequality monitoring at the global and/or national level. Design We outline the scope, content, and intended uses/application of the following: Health Equity Monitor database and theme page; State of inequality: reproductive, maternal, newborn, and child health report; Handbook on health inequality monitoring: with a focus on low- and middle-income countries; Health inequality monitoring eLearning module; Monitoring health inequality: an essential step for achieving health equity advocacy booklet and accompanying video series; and capacity building workshops conducted in WHO Member States and Regions. Conclusions The paper concludes by considering how the work of the WHO can be expanded upon to promote the establishment of sustainable and robust inequality monitoring systems across a variety of health topics among Member States and at the global level. PMID:26387506

The human dimension of fire regimes on Earth.

PubMed

Bowman, David M J S; Balch, Jennifer; Artaxo, Paulo; Bond, William J; Cochrane, Mark A; D'Antonio, Carla M; Defries, Ruth; Johnston, Fay H; Keeley, Jon E; Krawchuk, Meg A; Kull, Christian A; Mack, Michelle; Moritz, Max A; Pyne, Stephen; Roos, Christopher I; Scott, Andrew C; Sodhi, Navjot S; Swetnam, Thomas W; Whittaker, Robert

2011-12-01

Humans and their ancestors are unique in being a fire-making species, but 'natural' (i.e. independent of humans) fires have an ancient, geological history on Earth. Natural fires have influenced biological evolution and global biogeochemical cycles, making fire integral to the functioning of some biomes. Globally, debate rages about the impact on ecosystems of prehistoric human-set fires, with views ranging from catastrophic to negligible. Understanding of the diversity of human fire regimes on Earth in the past, present and future remains rudimentary. It remains uncertain how humans have caused a departure from 'natural' background levels that vary with climate change. Available evidence shows that modern humans can increase or decrease background levels of natural fire activity by clearing forests, promoting grazing, dispersing plants, altering ignition patterns and actively suppressing fires, thereby causing substantial ecosystem changes and loss of biodiversity. Some of these contemporary fire regimes cause substantial economic disruptions owing to the destruction of infrastructure, degradation of ecosystem services, loss of life, and smoke-related health effects. These episodic disasters help frame negative public attitudes towards landscape fires, despite the need for burning to sustain some ecosystems. Greenhouse gas-induced warming and changes in the hydrological cycle may increase the occurrence of large, severe fires, with potentially significant feedbacks to the Earth system. Improved understanding of human fire regimes demands: (1) better data on past and current human influences on fire regimes to enable global comparative analyses, (2) a greater understanding of different cultural traditions of landscape burning and their positive and negative social, economic and ecological effects, and (3) more realistic representations of anthropogenic fire in global vegetation and climate change models. We provide an historical framework to promote understanding of the development and diversification of fire regimes, covering the pre-human period, human domestication of fire, and the subsequent transition from subsistence agriculture to industrial economies. All of these phases still occur on Earth, providing opportunities for comparative research.

The human dimension of fire regimes on Earth

PubMed Central

Bowman, David M J S; Balch, Jennifer; Artaxo, Paulo; Bond, William J; Cochrane, Mark A; D'Antonio, Carla M; DeFries, Ruth; Johnston, Fay H; Keeley, Jon E; Krawchuk, Meg A; Kull, Christian A; Mack, Michelle; Moritz, Max A; Pyne, Stephen; Roos, Christopher I; Scott, Andrew C; Sodhi, Navjot S; Swetnam, Thomas W; Whittaker, Robert

2011-01-01

Humans and their ancestors are unique in being a fire-making species, but ‘natural’ (i.e. independent of humans) fires have an ancient, geological history on Earth. Natural fires have influenced biological evolution and global biogeochemical cycles, making fire integral to the functioning of some biomes. Globally, debate rages about the impact on ecosystems of prehistoric human-set fires, with views ranging from catastrophic to negligible. Understanding of the diversity of human fire regimes on Earth in the past, present and future remains rudimentary. It remains uncertain how humans have caused a departure from ‘natural’ background levels that vary with climate change. Available evidence shows that modern humans can increase or decrease background levels of natural fire activity by clearing forests, promoting grazing, dispersing plants, altering ignition patterns and actively suppressing fires, thereby causing substantial ecosystem changes and loss of biodiversity. Some of these contemporary fire regimes cause substantial economic disruptions owing to the destruction of infrastructure, degradation of ecosystem services, loss of life, and smoke-related health effects. These episodic disasters help frame negative public attitudes towards landscape fires, despite the need for burning to sustain some ecosystems. Greenhouse gas-induced warming and changes in the hydrological cycle may increase the occurrence of large, severe fires, with potentially significant feedbacks to the Earth system. Improved understanding of human fire regimes demands: (1) better data on past and current human influences on fire regimes to enable global comparative analyses, (2) a greater understanding of different cultural traditions of landscape burning and their positive and negative social, economic and ecological effects, and (3) more realistic representations of anthropogenic fire in global vegetation and climate change models. We provide an historical framework to promote understanding of the development and diversification of fire regimes, covering the pre-human period, human domestication of fire, and the subsequent transition from subsistence agriculture to industrial economies. All of these phases still occur on Earth, providing opportunities for comparative research. PMID:22279247

C-GLORSv5: an improved multipurpose global ocean eddy-permitting physical reanalysis

NASA Astrophysics Data System (ADS)

Storto, Andrea; Masina, Simona

2016-11-01

Global ocean reanalyses combine in situ and satellite ocean observations with a general circulation ocean model to estimate the time-evolving state of the ocean, and they represent a valuable tool for a variety of applications, ranging from climate monitoring and process studies to downstream applications, initialization of long-range forecasts and regional studies. The purpose of this paper is to document the recent upgrade of C-GLORS (version 5), the latest ocean reanalysis produced at the Centro Euro-Mediterraneo per i Cambiamenti Climatici (CMCC) that covers the meteorological satellite era (1980-present) and it is being updated in delayed time mode. The reanalysis is run at eddy-permitting resolution (1/4° horizontal resolution and 50 vertical levels) and consists of a three-dimensional variational data assimilation system, a surface nudging and a bias correction scheme. With respect to the previous version (v4), C-GLORSv5 contains a number of improvements. In particular, background- and observation-error covariances have been retuned, allowing a flow-dependent inflation in the globally averaged background-error variance. An additional constraint on the Arctic sea-ice thickness was introduced, leading to a realistic ice volume evolution. Finally, the bias correction scheme and the initialization strategy were retuned. Results document that the new reanalysis outperforms the previous version in many aspects, especially in representing the variability of global heat content and associated steric sea level in the last decade, the top 80 m ocean temperature biases and root mean square errors, and the Atlantic Ocean meridional overturning circulation; slight worsening in the high-latitude salinity and deep ocean temperature emerge though, providing the motivation for further tuning of the reanalysis system. The dataset is available in NetCDF format at doi:10.1594/PANGAEA.857995.

The human dimension of fire regimes on Earth

USGS Publications Warehouse

Bowman, David M.J.S.; Balch, Jennifer; Artaxo, Paulo; Bond, William J.; Cochrane, Mark A.; D'Antonio, Carla M.; DeFries, Ruth; Johnston, Fay H.; Keeley, Jon E.; Krawchuk, Meg A.; Kull, Christian A.; Michelle, Mack; Moritz, Max A.; Pyne, Stephen; Roos, Christopher I.; Scott, Andrew C.; Sodhi, Navjot S.; Swetnam, Thomas W.

2011-01-01

Humans and their ancestors are unique in being a fire-making species, but 'natural' (i.e. independent of humans) fires have an ancient, geological history on Earth. Natural fires have influenced biological evolution and global biogeochemical cycles, making fire integral to the functioning of some biomes. Globally, debate rages about the impact on ecosystems of prehistoric human-set fires, with views ranging from catastrophic to negligible. Understanding of the diversity of human fire regimes on Earth in the past, present and future remains rudimentary. It remains uncertain how humans have caused a departure from 'natural' background levels that vary with climate change. Available evidence shows that modern humans can increase or decrease background levels of natural fire activity by clearing forests, promoting grazing, dispersing plants, altering ignition patterns and actively suppressing fires, thereby causing substantial ecosystem changes and loss of biodiversity. Some of these contemporary fire regimes cause substantial economic disruptions owing to the destruction of infrastructure, degradation of ecosystem services, loss of life, and smoke-related health effects. These episodic disasters help frame negative public attitudes towards landscape fires, despite the need for burning to sustain some ecosystems. Greenhouse gas-induced warming and changes in the hydrological cycle may increase the occurrence of large, severe fires, with potentially significant feedbacks to the Earth system. Improved understanding of human fire regimes demands: (1) better data on past and current human influences on fire regimes to enable global comparative analyses, (2) a greater understanding of different cultural traditions of landscape burning and their positive and negative social, economic and ecological effects, and (3) more realistic representations of anthropogenic fire in global vegetation and climate change models. We provide an historical framework to promote understanding of the development and diversification of fire regimes, covering the pre-human period, human domestication of fire, and the subsequent transition from subsistence agriculture to industrial economies. All of these phases still occur on Earth, providing opportunities for comparative research.

Global Seasonality of Rotavirus Disease

PubMed Central

Patel, Manish M.; Pitzer, Virginia; Alonso, Wladimir J.; Vera, David; Lopman, Ben; Tate, Jacqueline; Viboud, Cecile; Parashar, Umesh D.

2012-01-01

Background A substantial number of surveillance studies have documented rotavirus prevalence among children admitted for dehydrating diarrhea. We sought to establish global seasonal patterns of rotavirus disease before widespread vaccine introduction. Methods We reviewed studies of rotavirus detection in children with diarrhea published since 1995. We assessed potential relationships between seasonal prevalence and locality by plotting the average monthly proportion of diarrhea cases positive for rotavirus according to geography, country development, and latitude. We used linear regression to identify variables that were potentially associated with the seasonal intensity of rotavirus. Results Among a total of 99 studies representing all six geographical regions of the world, patterns of year-round disease were more evident in low- and low-middle income countries compared with upper-middle and high income countries where disease was more likely to be seasonal. The level of country development was a stronger predictor of strength of seasonality (P=0.001) than geographical location or climate. However, the observation of distinctly different seasonal patterns of rotavirus disease in some countries with similar geographical location, climate and level of development indicate that a single unifying explanation for variation in seasonality of rotavirus disease is unlikely. Conclusion While no unifying explanation emerged for varying rotavirus seasonality globally, the country income level was somewhat more predictive of the likelihood of having seasonal disease than other factors. Future evaluation of the effect of rotavirus vaccination on seasonal patterns of disease in different settings may help understand factors that drive the global seasonality of rotavirus disease. PMID:23190782

Mars Aerocapture and Validation of Mars-GRAM with TES Data

NASA Technical Reports Server (NTRS)

Justus, C. G.; Duvall, Aleta; Keller, Vernon W.

2005-01-01

Mars Global Reference Atmospheric Model (Mars-GRAM) is a widely-used engineering- level Mars atmospheric model. Applications include systems design, performance analysis, and operations planning for aerobraking, entry descent and landing, and aerocapture. Typical Mars aerocapture periapsis altitudes (for systems with rigid-aeroshell heat shields) are about 50 km. This altitude is above the 0-40 km height range covered by Mars Global Surveyor Thermal Emission Spectrometer (TES) nadir observations. Recently, TES limb sounding data have been made available, spanning more than two Mars years (more than 200,000 data profiles) with altitude coverage up to about 60 km, well within the height range of interest for aerocapture. Results are presented comparing Mars-GRAM atmospheric density with densities from TES nadir and limb sounding observations. A new Mars-GRAM feature is described which allows individual TES nadir or limb profiles to be extracted from the large TES databases, and to be used as an optional replacement for standard Mars-GRAM background (climatology) conditions. For Monte-Carlo applications such as aerocapture guidance and control studies, Mars-GRAM perturbations are available using these TES profile background conditions.

In search of laterally heterogeneous viscosity models of Glacial Isostatic Adjustment with the ICE-6G_C global ice history model

NASA Astrophysics Data System (ADS)

Li, Tanghua; Wu, Patrick; Steffen, Holger; Wang, Hansheng

2018-05-01

Most models of Glacial Isostatic Adjustment (GIA) assume that the Earth is laterally homogeneous. However, seismic and geological observations clearly show that the Earth's mantle is laterally heterogeneous. Previous studies of GIA with lateral heterogeneity mostly focused on its effect or sensitivity on GIA predictions, and it is not clear to what extent can lateral heterogeneity solve the misfits between GIA predictions and observations. Our aim is to search for the best 3D viscosity models that can simultaneously fit the global relative sea-level (RSL) data, the peak uplift rates (u-dot from GNSS) and peak gravity-rate-of-change (g-dot from the GRACE satellite mission) in Laurentia and Fennoscandia. However, the search is dependent on the ice and viscosity model inputs - the latter depends on the background viscosity and the seismic tomography models used. In this paper, the ICE-6G_C ice model, with Bunge & Grand's seismic tomography model and background viscosity models close to VM5 will be assumed. A Coupled Laplace-Finite Element Method is used to compute gravitationally self-consistent sea level change with time dependent coastlines and rotational feedback in addition to changes in deformation, gravity and the state of stress. Several laterally heterogeneous models are found to fit the global sea level data better than laterally homogeneous models. Two of these laterally heterogeneous models also fit the ICE-6G_C peak g-dot and u-dot rates observed in Laurentia simultaneously. However, even with the introduction of lateral heterogeneity, no model that is able to fit the present-day g-dot and uplift rate data in Fennoscandia has been found. Therefore, either the ice history of ICE-6G_C in Fennoscandia and Barent Sea needs some modifications, or the sub-lithospheric property/non-thermal effect underneath northern Europe must be different from that underneath Laurentia.

Links between global and local shape perception, coloured backgrounds, colour discrimination, and non-verbal IQ.

PubMed

Dore, Patricia; Dumani, Ardian; Wyatt, Geddes; Shepherd, Alex J

2018-03-16

This study explored associations between local and global shape perception on coloured backgrounds, colour discrimination, and non-verbal IQ (NVIQ). Five background colours were chosen for the local and global shape tasks that were tailored for the cone-opponent pathways early in the visual system (cardinal colour directions: L-M, loosely, reddish-greenish; and S-(L + M), or tritan colours, loosely, blueish-yellowish; where L, M and S refer to the long, middle and short wavelength sensitive cones). Participants also completed the Farnsworth-Munsell 100-hue test (FM100) to determine whether performance on the local and global shape tasks correlated with colour discrimination overall, or with performance on the L-M and tritan subsets of the FM100 test. Overall performance on the local and global shape tasks did correlate with scores on the FM100 tests, despite the colour of the background being irrelevant to the shape tasks. There were also significantly larger associations between scores for the L-M subset of the FM100 test, compared to the tritan subset, and accuracy on some of the shape tasks on the reddish, greenish and neutral backgrounds. Participants also completed the non-verbal components of the WAIS and the SPM+ version of Raven's progressive matrices, to determine whether performance on the FM100 test, and on the local and global shape tasks, correlated with NVIQ. FM100 scores correlated significantly with both WAIS and SPM+ scores. These results extend previous work that has indicated FM100 performance is not purely a measure of colour discrimination, but also involves aspects of each participant's NVIQ, such as the ability to attend to local and global aspects of the test, part-whole relationships, perceptual organisation and good visuomotor skills. Overall performance on the local and global shape tasks correlated only with the WAIS scores, not the SPM+. These results indicate that those aspects of NVIQ that engage spatial comprehension of local-global relationships and manual manipulation (WAIS), rather than more abstract reasoning (SPM+), are related to performance on the local and global shape tasks. Links are presented between various measures of NVIQ and performance on visual tasks, but they are currently seldom addressed in studies of either shape or colour perception. Further studies to explore these issues are recommended. Copyright © 2018 Elsevier Ltd. All rights reserved.

Change of ENSO characteristics in response to global warming

NASA Astrophysics Data System (ADS)

Sun, X.; Xia, Y.; Yan, Y.; Feng, W.; Huang, F.; Yang, X. Q.

2017-12-01

By using datasets of HadISST monthly SST from 1895 to 2014 and 600-year simulations of two CESM model experiments with/without doubling of CO2 concentration, ENSO characteristics are compared pre- and post- global warming. The main results are as follows. Due to global warming, the maximum climatological SST warming occurs in the tropical western Pacific (La Niña-like background warming) and the tropical eastern Pacific (El Niño-like background warming) for observations and model, respectively, resulting in opposite zonal SST gradient anomalies in the tropical Pacific. The La Niña-like background warming induces intense surface divergence in the tropical central Pacific, which enhances the easterly trade winds in the tropical central-western Pacific and shifts the strongest ocean-atmosphere coupling westward, correspondingly. On the contrary, the El Niño-like background warming causes westerly winds in the whole tropical Pacific and moves the strongest ocean-atmosphere coupling eastward. Under the La Niña-like background warming, ENSO tends to develop and mature in the tropical central Pacific, because the background easterly wind anomaly weakens the ENSO-induced westerly wind anomaly in the tropical western Pacific, leading to the so-called "Central Pacific ENSO (CP ENSO)". However, the so-called "Eastern Pacific ENSO (EP ENSO)" is likely formed due to increased westerly wind anomaly by the El Niño-like background warming. ENSO lifetime is significantly extended under both the El Niño-like and the La Niña-like background warmings, and especially, it can be prolonged by up to 3 months in the situation of El Niño-like background warming. The prolonged El Nino lifetime mainly applies to extreme El Niño events, which is caused by earlier outbreak of the westerly wind bursts, shallower climatological thermocline depth and weaker "discharge" rate of the ENSO warm signal in response to global warming. Results from both observations and the model also show that the frequency of ENSO events greatly increases due to global warming, and many more extreme El Niño and La Niña events appear under the El Niño-like and the La Niña-like background warmings, respectively. This study reconciles the phenomena and mechanisms of different characteristics of ENSO changes in observations and models.

Global health initiative investments and health systems strengthening: a content analysis of global fund investments

PubMed Central

2013-01-01

Background Millions of dollars are invested annually under the umbrella of national health systems strengthening. Global health initiatives provide funding for low- and middle-income countries through disease-oriented programmes while maintaining that the interventions simultaneously strengthen systems. However, it is as yet unclear which, and to what extent, system-level interventions are being funded by these initiatives, nor is it clear how much funding they allocate to disease-specific activities – through conventional ‘vertical-programming’ approach. Such funding can be channelled to one or more of the health system building blocks while targeting disease(s) or explicitly to system-wide activities. Methods We operationalized the World Health Organization health system framework of the six building blocks to conduct a detailed assessment of Global Fund health system investments. Our application of this framework framework provides a comprehensive quantification of system-level interventions. We applied this systematically to a random subset of 52 of the 139 grants funded in Round 8 of the Global Fund to Fight AIDS, Tuberculosis and Malaria (totalling approximately US$1 billion). Results According to the analysis, 37% (US$ 362 million) of the Global Fund Round 8 funding was allocated to health systems strengthening. Of that, 38% (US$ 139 million) was for generic system-level interventions, rather than disease-specific system support. Around 82% of health systems strengthening funding (US$ 296 million) was allocated to service delivery, human resources, and medicines & technology, and within each of these to two to three interventions. Governance, financing, and information building blocks received relatively low funding. Conclusions This study shows that a substantial portion of Global Fund’s Round 8 funds was devoted to health systems strengthening. Dramatic skewing among the health system building blocks suggests opportunities for more balanced investments with regard to governance, financing, and information system related interventions. There is also a need for agreement, by researchers, recipients, and donors, on keystone interventions that have the greatest system-level impacts for the cost-effective use of funds. Effective health system strengthening depends on inter-agency collaboration and country commitment along with concerted partnership among all the stakeholders working in the health system. PMID:23889824

Quality evaluation of extracted ion chromatograms and chromatographic peaks in liquid chromatography/mass spectrometry-based metabolomics data

PubMed Central

2014-01-01

Background Extracted ion chromatogram (EIC) extraction and chromatographic peak detection are two important processing procedures in liquid chromatography/mass spectrometry (LC/MS)-based metabolomics data analysis. Most commonly, the LC/MS technique employs electrospray ionization as the ionization method. The EICs from LC/MS data are often noisy and contain high background signals. Furthermore, the chromatographic peak quality varies with respect to its location in the chromatogram and most peaks have zigzag shapes. Therefore, there is a critical need to develop effective metrics for quality evaluation of EICs and chromatographic peaks in LC/MS based metabolomics data analysis. Results We investigated a comprehensive set of potential quality evaluation metrics for extracted EICs and detected chromatographic peaks. Specifically, for EIC quality evaluation, we analyzed the mass chromatographic quality index (MCQ index) and propose a novel quality evaluation metric, the EIC-related global zigzag index, which is based on an EIC's first order derivatives. For chromatographic peak quality evaluation, we analyzed and compared six metrics: sharpness, Gaussian similarity, signal-to-noise ratio, peak significance level, triangle peak area similarity ratio and the local peak-related local zigzag index. Conclusions Although the MCQ index is suited for selecting and aligning analyte components, it cannot fairly evaluate EICs with high background signals or those containing only a single peak. Our proposed EIC related global zigzag index is robust enough to evaluate EIC qualities in both scenarios. Of the six peak quality evaluation metrics, the sharpness, peak significance level, and zigzag index outperform the others due to the zigzag nature of LC/MS chromatographic peaks. Furthermore, using several peak quality metrics in combination is more efficient than individual metrics in peak quality evaluation. PMID:25350128

Impact of the Fukushima accident on tritium, radiocarbon and radiocesium levels in seawater of the western North Pacific Ocean: A comparison with pre-Fukushima situation.

PubMed

Povinec, P P; Liong Wee Kwong, L; Kaizer, J; Molnár, M; Nies, H; Palcsu, L; Papp, L; Pham, M K; Jean-Baptiste, P

2017-01-01

Tritium, radiocarbon and radiocesium concentrations in water column samples in coastal waters offshore Fukushima and in the western North Pacific Ocean collected in 2011-2012 during the Ka'imikai-o-Kanaloa (KoK) cruise are compared with other published results. The highest levels in surface seawater were observed for 134 Cs and 137 Cs in seawater samples collected offshore Fukushima (up to 1.1 Bq L -1 ), which represent an increase by about three orders of magnitude when compared with the pre-Fukushima concentration. Tritium levels were much lower (up to 0.15 Bq L -1 ), representing an increase by about a factor of 6. The impact on the radiocarbon distribution was measurable, but the observed levels were only by about 9% above the global fallout background. The 137 Cs (and similarly 134 Cs) inventory in the water column of the investigated western North Pacific region was (2.7 ± 0.4) PBq, while for 3 H it was only (0.3 ± 0.2) PBq. Direct releases of highly contaminated water from the damaged Fukushima NPP, as well as dry and wet depositions of these radionuclides over the western North Pacific considerably changed their distribution patterns in seawater. Presently we can distinguish Fukushima labeled waters from global fallout background thanks to short-lived 134 Cs. However, in the long-term perspective when 134 Cs will decay, new distribution patterns of 3 H, 14 C and 137 Cs in the Pacific Ocean should be established for future oceanographic and climate change studies in the Pacific Ocean. Copyright © 2016 Elsevier Ltd. All rights reserved.

Global public health today: connecting the dots

PubMed Central

Lomazzi, Marta; Jenkins, Christopher; Borisch, Bettina

2016-01-01

Background Global public health today faces new challenges and is impacted by a range of actors from within and outside state boundaries. The diversity of the actors involved has created challenges and a complex environment that requires a new context-tailored global approach. The World Federation of Public Health Associations has embarked on a collaborative consultation with the World Health Organization to encourage a debate on how to adapt public health to its future role in global health. Design A qualitative study was undertaken. High-level stakeholders from leading universities, multilateral organizations, and other institutions worldwide participated in the study. Inductive content analyses were performed. Results Stakeholders underscored that global public health today should tackle the political, commercial, economic, social, and environmental determinants of health and social inequalities. A multisectoral and holistic approach should be guaranteed, engaging public health in broad dialogues and a concerted decision-making process. The connection between neoliberal ideology and public health reforms should be taken into account. The WHO must show leadership and play a supervising and technical role. More and better data are required across many programmatic areas of public health. Resources should be allocated in a sustainable and accountable way. Public health professionals need new skills that should be provided by a collaborative global education system. A common framework context-tailored to influence governments has been evaluated as useful. Conclusions The study highlighted some of the main public health challenges currently under debate in the global arena, providing interesting ideas. A more inclusive integrated vision of global health in its complexity, shared and advocated for by all stakeholders involved in decision-making processes, is crucial. This vision represents the first step in innovating public health at the global level and should lead to a serious rethinking of education curricula to allow the next generation to engage within political contexts for restructuring global public health. PMID:26899773

Canopy near-infrared reflectance and terrestrial photosynthesis.

PubMed

Badgley, Grayson; Field, Christopher B; Berry, Joseph A

2017-03-01

Global estimates of terrestrial gross primary production (GPP) remain highly uncertain, despite decades of satellite measurements and intensive in situ monitoring. We report a new approach for quantifying the near-infrared reflectance of terrestrial vegetation (NIR V ). NIR V provides a foundation for a new approach to estimate GPP that consistently untangles the confounding effects of background brightness, leaf area, and the distribution of photosynthetic capacity with depth in canopies using existing moderate spatial and spectral resolution satellite sensors. NIR V is strongly correlated with solar-induced chlorophyll fluorescence, a direct index of photons intercepted by chlorophyll, and with site-level and globally gridded estimates of GPP. NIR V makes it possible to use existing and future reflectance data as a starting point for accurately estimating GPP.

Canopy near-infrared reflectance and terrestrial photosynthesis

PubMed Central

Badgley, Grayson; Field, Christopher B.; Berry, Joseph A.

2017-01-01

Global estimates of terrestrial gross primary production (GPP) remain highly uncertain, despite decades of satellite measurements and intensive in situ monitoring. We report a new approach for quantifying the near-infrared reflectance of terrestrial vegetation (NIRV). NIRV provides a foundation for a new approach to estimate GPP that consistently untangles the confounding effects of background brightness, leaf area, and the distribution of photosynthetic capacity with depth in canopies using existing moderate spatial and spectral resolution satellite sensors. NIRV is strongly correlated with solar-induced chlorophyll fluorescence, a direct index of photons intercepted by chlorophyll, and with site-level and globally gridded estimates of GPP. NIRV makes it possible to use existing and future reflectance data as a starting point for accurately estimating GPP. PMID:28345046

The Clinical Nurse Leader--new nursing role with global implications.

PubMed

Baernholdt, M; Cottingham, S

2011-03-01

This paper describes the development of the Clinical Nurse Leader (CNL ©) role and education, the CNL's impact and potential to improve quality globally. The need for clinical nurse leadership to improve the quality of health care systems while controlling costs is recognized in reports internationally. In the USA, a new nursing role, the CNL, was developed in response to such reports. CNLs are master's level nurse graduates (although not necessarily recruited from a nursing background) with the skills and knowledge to create change within complex systems and improve outcomes while they remain direct care providers. This innovative role can be adapted worldwide to improve the quality of health care systems. © 2010 The Authors. International Nursing Review © 2010 International Council of Nurses.

Association of Global DNA Methylation and Global DNA Hydroxymethylation with Metals and Other Exposures in Human Blood DNA Samples

PubMed Central

Tang, Wan-yee; Shang, Yan; Umans, Jason G.; Francesconi, Kevin A.; Goessler, Walter; Ledesma, Marta; Leon, Montserrat; Laclaustra, Martin; Pollak, Jonathan; Guallar, Eliseo; Cole, Shelley A.; Fallin, M. Dani; Navas-Acien, Ana

2014-01-01

Background: The association between human blood DNA global methylation and global hydroxymethylation has not been evaluated in population-based studies. No studies have evaluated environmental determinants of global DNA hydroxymethylation, including exposure to metals. Objective: We evaluated the association between global DNA methylation and global DNA hydroxymethylation in 48 Strong Heart Study participants for which selected metals had been measured in urine at baseline and DNA was available from 1989–1991 (visit 1) and 1998–1999 (visit 3). Methods: We measured the percentage of 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in samples using capture and detection antibodies followed by colorimetric quantification. We explored the association of participant characteristics (i.e., age, adiposity, smoking, and metal exposure) with both global DNA methylation and global DNA hydroxymethylation. Results: The Spearman’s correlation coefficient for 5-mC and 5-hmC levels was 0.32 (p = 0.03) at visit 1 and 0.54 (p < 0.001) at visit 3. Trends for both epigenetic modifications were consistent across potential determinants. In cross-sectional analyses, the odds ratios of methylated and hydroxymethylated DNA were 1.56 (95% CI: 0.95, 2.57) and 1.76 (95% CI: 1.07, 2.88), respectively, for the comparison of participants above and below the median percentage of dimethylarsinate. The corresponding odds ratios were 1.64 (95% CI: 1.02, 2.65) and 1.16 (95% CI: 0.70, 1.94), respectively, for the comparison of participants above and below the median cadmium level. Arsenic exposure and metabolism were consistently associated with both epigenetic markers in cross-sectional and prospective analyses. The positive correlation of 5-mC and 5-hmC levels was confirmed in an independent study population. Conclusions: Our findings support that both epigenetic measures are related at the population level. The consistent trends in the associations between these two epigenetic modifications and the characteristics evaluated, especially arsenic exposure and metabolism, suggest the need for understanding which of the two measures is a better biomarker for environmental epigenetic effects in future large-scale epidemiologic studies. Citation: Tellez-Plaza M, Tang WY, Shang Y, Umans JG, Francesconi KA, Goessler W, Ledesma M, Leon M, Laclaustra M, Pollak J, Guallar E, Cole SA, Fallin MD, Navas-Acien A. 2014. Association of global DNA methylation and global DNA hydroxymethylation with metals and other exposures in human blood DNA samples. Environ Health Perspect 122:946–954; http://dx.doi.org/10.1289/ehp.1306674 PMID:24769358

Mercury concentrations in urine of amerindian populations near oil fields in the peruvian and ecuadorian amazon.

PubMed

Webb, Jena; Coomes, Oliver T; Ross, Nancy; Mergler, Donna

2016-11-01

Mercury is a global contaminant with toxic, persistent effects on human health. Petroleum extraction is an important source of elemental mercury; little is known about human exposure levels near oil fields in the Amazon basin. To characterize mercury levels in people living near oil production sites in the Peruvian and Ecuadorian Amazon, controlling for fish consumption, occupation, source of water and socio-demographic characteristics. Analyze mercury levels in urine samples using cold vapour atomic fluorescence spectrometry from 76 indigenous men and women in eight riverine communities situated near oil wells or pipelines. Subjects answered a questionnaire soliciting socio-demographic, occupational and dietary information. Data were analyzed using multiple linear regression modeling. The mean value of U-Hg was 2.61μg/g creatinine (95% CI: 2.14-3.08), with 7% of the sample recording values above the global background standard suggested by The World Health Organization (5μg/g creatinine). Women who used water from a surface source had two and a half times the amount of mercury in their urine (mean=3.70μg/g creatinine, 95% CI: 2.26-5.15) compared with women who used other water sources (mean =1.39μg/g creatinine, 95% CI: 0.51-2.25). Men who were involved in an oil clean-up operation had twice as much mercury in their urine (mean =3.07μg/g creatinine, 95% CI: 1.97-4.16) as did those who worked on other tasks (mean =1.56μg/g creatinine, 95% CI: 1.48-2.65). Mercury levels were not associated with the number of fish meals per week. Indigenous peoples of the Peruvian and Ecuadorian Amazon living near oil production sites generally had urine mercury levels within the global background standard suggested by the World Health Organization. Increased levels of mercury in urine were detected for men involved in oil spill remediation and for women who relied on surface water for household needs. These findings signal the need for strict safety measures to limit the amount of oil entering the waterways in Andean Amazonia so as to protect the health of indigenous people. Copyright © 2016 Elsevier Inc. All rights reserved.

No psychological effect of color context in a low level vision task

PubMed Central

Pedley, Adam; Wade, Alex R

2013-01-01

Background: A remarkable series of recent papers have shown that colour can influence performance in cognitive tasks. In particular, they suggest that viewing a participant number printed in red ink or other red ancillary stimulus elements improves performance in tasks requiring local processing and impedes performance in tasks requiring global processing whilst the reverse is true for the colour blue. The tasks in these experiments require high level cognitive processing such as analogy solving or remote association tests and the chromatic effect on local vs. global processing is presumed to involve widespread activation of the autonomic nervous system. If this is the case, we might expect to see similar effects on all local vs. global task comparisons. To test this hypothesis, we asked whether chromatic cues also influence performance in tasks involving low level visual feature integration. Methods: Subjects performed either local (contrast detection) or global (form detection) tasks on achromatic dynamic Glass pattern stimuli. Coloured instructions, target frames and fixation points were used to attempt to bias performance to different task types. Based on previous literature, we hypothesised that red cues would improve performance in the (local) contrast detection task but would impede performance in the (global) form detection task.  Results: A two-way, repeated measures, analysis of covariance (2×2 ANCOVA) with gender as a covariate, revealed no influence of colour on either task, F(1,29) = 0.289, p = 0.595, partial η 2 = 0.002. Additional analysis revealed no significant differences in only the first attempts of the tasks or in the improvement in performance between trials. Discussion: We conclude that motivational processes elicited by colour perception do not influence neuronal signal processing in the early visual system, in stark contrast to their putative effects on processing in higher areas. PMID:25075280

The global radioxenon background and its impact on the detection capability of underground nuclear explosions (Invited)

NASA Astrophysics Data System (ADS)

Ringbom, A.

2010-12-01

A detailed knowledge of both the spatial and isotopic distribution of anthropogenic radioxenon is essential in investigations of the performance of the radioxenon part of the IMS, as well as in the development of techniques to discriminate radioxenon signatures from a nuclear explosion from other sources. Further, the production processes in the facilities causing the radioxenon background has to be understood and be compatible with simulations. In this work, several aspects of the observed atmospheric radioxenon background are investigated, including the global distribution as well as the current understanding of the observed isotopic ratios. Analyzed radioxenon data from the IMS, as well as from other measurement stations, are used to create an up-to-date description of the global radioxenon background, including all four CTBT relevant xenon isotopes (133Xe, 131mXe, 133mXe, and 135Xe). In addition, measured isotopic ratios will be compared to simulations of neutron induced fission of 235U, and the uncertainties will be discussed. Finally, the impact of the radioxenon background on the detection capability of the IMS will be investigated. This work is a continuation of studies [1,2] that was presented at the International Scientific Studies conference held in Vienna in 2009. [1] A. Ringbom, et.al., “Characterization of the global distribution of atmospheric radioxenons”, International Scientific Studies Conference on CTBT Verification, 10-12 June 2009. [2] R. D'Amours and A. Ringbom, “A study on the global detection capability of IMS for all CTBT relevant xenon isotopes“, International Scientific Studies Conference on CTBT Verification, 10-12 June 2009.

Globalizing Globalization: The Neo-Institutional Concept of a World Culture

ERIC Educational Resources Information Center

Trohler, Daniel

2009-01-01

In this paper, the author focuses on how globalization and education are addressed in research. More precisely, he concentrates on only one dominant approach to analyzing globalization and its effects on education and also the educational role within globalization. His thesis is that, with the background of Max Weber's Protestant ethic thesis,…

mHealth and global mental health: still waiting for the mH2 wedding?

PubMed Central

2014-01-01

Background Two phenomena have become increasingly visible over the past decade: the significant global burden of disease arising from mental illness and the rapid acceleration of mobile phone usage in poorer countries. Mental ill-health accounts for a significant proportion of global disability-adjusted life years (DALYs) and years lived with disability (YLDs), especially in poorer countries where a number of factors combine to exacerbate issues of undertreatment. Yet poorer countries have also witnessed significant investments in, and dramatic expansions of, mobile coverage and usage over the past decade. Debate The conjunction of high levels of mental illness and high levels of mobile phone usage in poorer countries highlights the potential for “mH2” interventions – i.e. mHealth (mobile technology-based) mental health interventions - to tackle global mental health challenges. However, global mental health movements and initiatives have yet to engage fully with this potential, partly because of scepticism towards technological solutions in general and partly because existing mH2 projects in mental health have often taken place in a fragmented, narrowly-focused, and small-scale manner. We argue for a deeper and more sustained engagement with mobile phone technology in the global mental health context, and outline the possible shape of an integrated mH2 platform for the diagnosis, treatment, and monitoring of mental health. Summary Existing and developing mH2 technologies represent an underutilised resource in global mental health. If development, evaluation, and implementation challenges are overcome, an integrated mH2 platform would make significant contributions to mental healthcare in multiple settings and contexts. PMID:24670011

Climate Change of 4°C GlobalWarming above Pre-industrial Levels

NASA Astrophysics Data System (ADS)

Wang, Xiaoxin; Jiang, Dabang; Lang, Xianmei

2018-07-01

Using a set of numerical experiments from 39 CMIP5 climate models, we project the emergence time for 4°C global warming with respect to pre-industrial levels and associated climate changes under the RCP8.5 greenhouse gas concentration scenario. Results show that, according to the 39 models, the median year in which 4°C global warming will occur is 2084. Based on the median results of models that project a 4°C global warming by 2100, land areas will generally exhibit stronger warming than the oceans annually and seasonally, and the strongest enhancement occurs in the Arctic, with the exception of the summer season. Change signals for temperature go outside its natural internal variabilities globally, and the signal-tonoise ratio averages 9.6 for the annual mean and ranges from 6.3 to 7.2 for the seasonal mean over the globe, with the greatest values appearing at low latitudes because of low noise. Decreased precipitation generally occurs in the subtropics, whilst increased precipitation mainly appears at high latitudes. The precipitation changes in most of the high latitudes are greater than the background variability, and the global mean signal-to-noise ratio is 0.5 and ranges from 0.2 to 0.4 for the annual and seasonal means, respectively. Attention should be paid to limiting global warming to 1.5°C, in which case temperature and precipitation will experience a far more moderate change than the natural internal variability. Large inter-model disagreement appears at high latitudes for temperature changes and at mid and low latitudes for precipitation changes. Overall, the intermodel consistency is better for temperature than for precipitation.

Influences on adolescent self-esteem in multicultural Canadian secondary schools.

PubMed

Khanlou, Nazilla

2004-01-01

Abstract This study examined the global and current self-esteem levels of adolescents in a community sample of 550 secondary school students in Canada. A cross-sectional design and the survey method were used. Respondents' individual (age and gender) and environmental (cultural background, acculturating group, family circumstances, and perception of support) attributes were considered. Influences that promoted or challenged their current self-esteem were examined. Eighteen percent of respondents and 43.4% of respondents' parents were immigrants. When the Rosenberg Self-Esteem scale was used, 27.6% of respondents had the highest global self-esteem level; when the Current Self-Esteem scale was used, 12.7% had the highest current self-esteem level. A significant gender difference was found, with male adolescents having higher self-esteem. The results indicate that, although self-esteem promotion can benefit from lifestyle-oriented activities, its growth takes place in the larger context of adolescents' relationships, school-related experiences, achievements, and attitudes toward themselves. The study findings can contribute to mental health promotion strategies in multicultural and immigrant-receiving community settings.

Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues

DTIC Science & Technology

2012-07-06

Missiles Congressional Research Service Forward-Based Global Strike ( FBGS ...Congressional Research Service 36 Forward-Based Global Strike ( FBGS ) Analysts have also explored the option of deploying long-range land-based

Developing a comprehensive conceptual arhictecture to support Earth sciences

NASA Astrophysics Data System (ADS)

Yang, C. P.; Xu, C.; Sun, M.; Li, Z.

2014-12-01

Global challenges require the comprehensive understanding of the earth system to make smarter descisions about scientific research, operational management, and educational activities. We conducted in the one and half year a comprehensive investigation about how to develop a comprehensive conceptual architecture for developing a cyberinfrastructure that can help address such global challenges. This includes three aspects of research and outreach: we first analyzed the conceptual architecture requirements from the earth science domains and the exisiting global and national systems from different agencies and organizations to consolidate a list of requirements from scientific, technological, and educational aspects. A conceptual design by considering these reqquirements and the latest development in enterprise arhictecture was conducted based on our past decade's investigation about cyberinfrastructure architecture for supporting different aspects. We also organized several levels of reviews by different levels of experts from different organizations and background to help us comment the completeness, reasonability, and practicality of the design. A comprehensive conceptual design will be released for public comments this spring to solicit the general comments for reaching a design as comprehensive as possible. The final design is scheduled to be published in 2015 to contribute to the general world wide scientists and CI builders in the geoscience domain and beyond.

Role of atmospheric heating over the South China Sea and western Pacific regions in modulating Asian summer climate under the global warming background

NASA Astrophysics Data System (ADS)

He, Bian; Yang, Song; Li, Zhenning

2016-05-01

The response of monsoon precipitation to global warming, which is one of the most significant climate change signals at the earth's surface, exhibits very distinct regional features, especially over the South China Sea (SCS) and adjacent regions in boreal summer. To understand the possible atmospheric dynamics in these specific regions under the global warming background, changes in atmospheric heating and their possible influences on Asian summer climate are investigated by both observational diagnosis and numerical simulations. Results indicate that heating in the middle troposphere has intensified in the SCS and western Pacific regions in boreal summer, accompanied by increased precipitation, cloud cover, and lower-tropospheric convergence and decreased sea level pressure. Sensitivity experiments show that middle and upper tropospheric heating causes an east-west feedback pattern between SCS and western Pacific and continental South Asia, which strengthens the South Asian High in the upper troposphere and moist convergence in the lower troposphere, consequently forcing a descending motion and adiabatic warming over continental South Asia. When air-sea interaction is considered, the simulation results are overall more similar to observations, and in particular the bias of precipitation over the Indian Ocean simulated by AGCMs has been reduced. The result highlights the important role of air-sea interaction in understanding the changes in Asian climate.

Effects of the Bering Strait closure on AMOC and global climate under different background climates

NASA Astrophysics Data System (ADS)

Hu, Aixue; Meehl, Gerald A.; Han, Weiqing; Otto-Bliestner, Bette; Abe-Ouchi, Ayako; Rosenbloom, Nan

2015-03-01

Previous studies have suggested that the status of the Bering Strait may have a significant influence on global climate variability on centennial, millennial, and even longer time scales. Here we use multiple versions of the National Center for Atmospheric Research (NCAR) Community Climate System Model (CCSM, versions 2 and 3) to investigate the influence of the Bering Strait closure/opening on the Atlantic Meridional Overturning Circulation (AMOC) and global mean climate under present-day, 15 thousand-year before present (kyr BP), and 112 kyr BP climate boundary conditions. Our results show that regardless of the version of the model used or the widely different background climates, the Bering Strait's closure produces a robust result of a strengthening of the AMOC, and an increase in the northward meridional heat transport in the Atlantic. As a consequence, the climate becomes warmer in the North Atlantic and the surrounding regions, but cooler in the North Pacific, leading to a seesaw-like climate change between these two basins. For the first time it is noted that the absence of the Bering Strait throughflow causes a slower motion of Arctic sea ice, a reduced upper ocean water exchange between the Arctic and North Atlantic, reduced sea ice export and less fresh water in the North Atlantic. These changes contribute positively to the increased upper ocean density there, thus strengthening the AMOC. Potentially these changes in the North Atlantic could have a significant effect on the ice sheets both upstream and downstream in ice age climate, and further influence global sea level changes.

Global Quality of Life Among WHI Women Aged 80 Years and Older

PubMed Central

Brunner, Robert L.; Hogan, Patricia E.; Danhauer, Suzanne C.; Brenes, Gretchen A.; Bowen, Deborah J.; Snively, Beverly M.; Goveas, Joseph S.; Saquib, Nazmus; Zaslavsky, Oleg; Shumaker, Sally A.

2016-01-01

Abstract Background. The number of older adults living to age 80 and older is increasing rapidly, particularly among women. Correlates of quality of life (QOL) in very advanced ages are not known. We examined the association of demographic, social-psychological, lifestyle, and physical health variables with global QOL in a Women’s Health Initiative (WHI) cohort of women aged 80 and older. Methods. 26,299 WHI participants, who had completed a recent psychosocial and medical update, were included in these analyses. Global QOL was assessed by a single item, asking the women to rate their overall QOL on a scale from 0 to 10. Characteristics of the women were examined by the level of their transformed global QOL scores (≤50, 50–70, ≥70), and multiple regression was used to examine which demographic, social-psychological, lifestyle and health variables were independently associated with higher global QOL. Results. Social-psychological and current health variables were more strongly associated with global QOL than a history of selected comorbid conditions. In particular, higher self-rated health and fewer depressive symptoms were the most strongly associated with better global QOL in WHI women ≥80 years. Conclusions. Interventions to reduce depressive symptoms and improve health may lead to better self-reported health and global QOL among older women. Physical and mental health screenings followed by evidence-based interventions are imperative in geriatric care. PMID:26858327

Estimating the Development Assistance for Health Provided to Faith-Based Organizations, 1990–2013

PubMed Central

Haakenstad, Annie; Johnson, Elizabeth; Graves, Casey; Olivier, Jill; Duff, Jean; Dieleman, Joseph L.

2015-01-01

Background Faith-based organizations (FBOs) have been active in the health sector for decades. Recently, the role of FBOs in global health has been of increased interest. However, little is known about the magnitude and trends in development assistance for health (DAH) channeled through these organizations. Material and Methods Data were collected from the 21 most recent editions of the Report of Voluntary Agencies. These reports provide information on the revenue and expenditure of organizations. Project-level data were also collected and reviewed from the Bill & Melinda Gates Foundation and the Global Fund to Fight AIDS, Tuberculosis and Malaria. More than 1,900 non-governmental organizations received funds from at least one of these three organizations. Background information on these organizations was examined by two independent reviewers to identify the amount of funding channeled through FBOs. Results In 2013, total spending by the FBOs identified in the VolAg amounted to US$1.53 billion. In 1990, FB0s spent 34.1% of total DAH provided by private voluntary organizations reported in the VolAg. In 2013, FBOs expended 31.0%. Funds provided by the Global Fund to FBOs have grown since 2002, amounting to $80.9 million in 2011, or 16.7% of the Global Fund’s contributions to NGOs. In 2011, the Gates Foundation’s contributions to FBOs amounted to $7.1 million, or 1.1% of the total provided to NGOs. Conclusion Development assistance partners exhibit a range of preferences with respect to the amount of funds provided to FBOs. Overall, estimates show that FBOS have maintained a substantial and consistent share over time, in line with overall spending in global health on NGOs. These estimates provide the foundation for further research on the spending trends and effectiveness of FBOs in global health. PMID:26042731

Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets

PubMed Central

2013-01-01

Background Consumption of high-fat diets has negative impacts on health and well-being, some of which may be epigenetically regulated. Selenium and folate are two compounds which influence epigenetic mechanisms. We investigated the hypothesis that post-weaning supplementation with adequate levels of selenium and folate in offspring of female mice fed a high-fat, low selenium and folate diet during gestation and lactation will lead to epigenetic changes of potential importance for long-term health. Methods Female offspring of mothers fed the experimental diet were either maintained on this diet (HF-low-low), or weaned onto a high-fat diet with sufficient levels of selenium and folate (HF-low-suf), for 8 weeks. Gene and protein expression, DNA methylation, and histone modifications were measured in colon and liver of female offspring. Results Adequate levels of selenium and folate post-weaning affected gene expression in colon and liver of offspring, including decreasing Slc2a4 gene expression. Protein expression was only altered in the liver. There was no effect of adequate levels of selenium and folate on global histone modifications in the liver. Global liver DNA methylation was decreased in mice switched to adequate levels of selenium and folate, but there was no effect on methylation of specific CpG sites within the Slc2a4 gene in liver. Conclusions Post-weaning supplementation with adequate levels of selenium and folate in female offspring of mice fed high-fat diets inadequate in selenium and folate during gestation and lactation can alter global DNA methylation in liver. This may be one factor through which the negative effects of a poor diet during early life can be ameliorated. Further research is required to establish what role epigenetic changes play in mediating observed changes in gene and protein expression, and the relevance of these changes to health. PMID:23497688

Pilot Institute on Global Change on Trace Gases and the Biosphere, 1988

NASA Technical Reports Server (NTRS)

Eddy, J. A.; Moore, B.

1998-01-01

Table of Contents: Summary; Background; General Framework for a Series of Institutes on Global Change; The 1988 Pilot Institute on Global Changes: Trace Gases and the Biosphere; Budget; List of Acronyms; and Attachments.

Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues

DTIC Science & Technology

2012-02-13

Ballistic Missiles Congressional Research Service Forward-Based Global Strike ( FBGS ...missiles in the CPGS program. Forward-Based Global Strike ( FBGS ) Analysts have also explored the option of deploying long-range land-based ballistic

Half-Truths and Consequences: The Legacy of Global 2000. Institution Analysis No. 34.

ERIC Educational Resources Information Center

Moore, Stephen

The 1980 "Global 2000 Report to the President" was based on a study which attempted to project international trends in population, pollution, and resource availability through the year 2000. This document discusses: (1) the background of Global 2000; (2) Global 2000 and the media; (3) Global 2000's impact on the environmental movement…

Relationship between urban eco-environment and competitiveness with the background of globalization: statistical explanation based on industry type newly classified with environment demand and environment pressure.

PubMed

Kang, Xiao-guang; Ma, Qing-Bin

2005-01-01

Within the global urban system, the statistical relationship between urban eco-environment (UE) and urban competitiveness (UC) (RUEC) is researched. Data showed that there is a statistically inverted-U relationship between UE and UC. Eco-environmental factor is put into the classification of industries, and gets six industrial types by two indexes viz. industries' eco-environmental demand and pressure. The statistical results showed that there is a strong relationship, for new industrial classification, between the changes of industrial structure and evolvement of UE. The drive mechanism of the evolvement of urban eco-environment, with human demand and global work division was analyzed. The conclusion is that the development stratege, industrial policies of cities, and environmental policies fo cities must be fit with their ranks among the global urban system. At the era of globalization, so far as the environmental policies, their rationality could not be assessed with the level of strictness, but it can enhance cities' competitiveness when they are fit with cities' capabilities to attract and control some sections of the industry's value-chain. None but these kinds of environmental policies can probably enhance the UC.

Global Patterns of Bacterial Beta-Diversity in Seafloor and Seawater Ecosystems

PubMed Central

Zinger, Lucie; Amaral-Zettler, Linda A.; Fuhrman, Jed A.; Horner-Devine, M. Claire; Huse, Susan M.; Welch, David B. Mark; Martiny, Jennifer B. H.; Sogin, Mitchell; Boetius, Antje; Ramette, Alban

2011-01-01

Background Marine microbial communities have been essential contributors to global biomass, nutrient cycling, and biodiversity since the early history of Earth, but so far their community distribution patterns remain unknown in most marine ecosystems. Methodology/Principal Findings The synthesis of 9.6 million bacterial V6-rRNA amplicons for 509 samples that span the global ocean's surface to the deep-sea floor shows that pelagic and benthic communities greatly differ, at all taxonomic levels, and share <10% bacterial types defined at 3% sequence similarity level. Surface and deep water, coastal and open ocean, and anoxic and oxic ecosystems host distinct communities that reflect productivity, land influences and other environmental constraints such as oxygen availability. The high variability of bacterial community composition specific to vent and coastal ecosystems reflects the heterogeneity and dynamic nature of these habitats. Both pelagic and benthic bacterial community distributions correlate with surface water productivity, reflecting the coupling between both realms by particle export. Also, differences in physical mixing may play a fundamental role in the distribution patterns of marine bacteria, as benthic communities showed a higher dissimilarity with increasing distance than pelagic communities. Conclusions/Significance This first synthesis of global bacterial distribution across different ecosystems of the World's oceans shows remarkable horizontal and vertical large-scale patterns in bacterial communities. This opens interesting perspectives for the definition of biogeographical biomes for bacteria of ocean waters and the seabed. PMID:21931760

Which factors are associated with global cognitive impairment in Wilson's disease?

PubMed Central

Frota, Norberto Anízio Ferreira; Barbosa, Egberto Reis; Porto, Claudia Sellitto; Lucato, Leandro Tavares; Ono, Carla Rachel; Buchpiguel, Carlos Alberto; Machado, Alexandre Aluizio Costa; Caramelli, Paulo

2016-01-01

Background Patients with Wilson's disease (WD) present cognitive impairment, especially in executive functions. Which other factors might be associated with global cognitive decline in these patients remains unclear. Objective To assess which factors are associated with worse performance on a global cognitive test in patients with WD. Methods Twenty patients with WD underwent cognitive assessment with the following tests: the Mini-Mental State Examination (MMSE), Dementia Rating Scale (DRS), verbal fluency test, brief cognitive battery, clock drawing test, Frontal Assessment Battery, Stroop test, Wisconsin card sorting test, Hopper test, cubes (WAIS) and the Pfeffer questionnaire. MRI changes were quantified. Patients with poor performance on the DRS were compared to patients with normal performance. Results Nine patients had a poor performance on the DRS. This group had lower educational level (9.11±3.58× 12.82±3.06) and a greater number of changes on MRI (9.44±2.74× 6.27±2.45). The presence of hyperintensity in the globus pallidus on MRI was more frequent in this group (66.6% vs 9.0%), with OR=5.38 (95% CI 0.85-33.86). Conclusion Global cognitive impairment was prevalent in this sample of patients with WD and was associated with low educational level, number of changes on MRI and MRI hyperintensity in the globus pallidus. PMID:29213476

Winter color polymorphisms identify global hot spots for evolutionary rescue from climate change.

PubMed

Mills, L Scott; Bragina, Eugenia V; Kumar, Alexander V; Zimova, Marketa; Lafferty, Diana J R; Feltner, Jennifer; Davis, Brandon M; Hackländer, Klaus; Alves, Paulo C; Good, Jeffrey M; Melo-Ferreira, José; Dietz, Andreas; Abramov, Alexei V; Lopatina, Natalia; Fay, Kairsten

2018-03-02

Maintenance of biodiversity in a rapidly changing climate will depend on the efficacy of evolutionary rescue, whereby population declines due to abrupt environmental change are reversed by shifts in genetically driven adaptive traits. However, a lack of traits known to be under direct selection by anthropogenic climate change has limited the incorporation of evolutionary processes into global conservation efforts. In 21 vertebrate species, some individuals undergo a seasonal color molt from summer brown to winter white as camouflage against snow, whereas other individuals remain brown. Seasonal snow duration is decreasing globally, and fitness is lower for winter white animals on snowless backgrounds. Based on 2713 georeferenced samples of known winter coat color-from eight species across trophic levels-we identify environmentally driven clinal gradients in winter coat color, including polymorphic zones where winter brown and white morphs co-occur. These polymorphic zones, underrepresented by existing global protected area networks, indicate hot spots for evolutionary rescue in a changing climate. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues

DTIC Science & Technology

2013-01-10

and Long-Range Ballistic Missiles Congressional Research Service Forward-Based Global Strike ( FBGS ...they may address the nuclear ambiguity issues raised by long-range ballistic missiles in the CPGS program. Forward-Based Global Strike ( FBGS

Observations of Europe wide Trends in background and peak O3, CO and NO2 levels

NASA Astrophysics Data System (ADS)

Fleming, Z. L.; Monks, P. S.; Brunsdon, C.; Henne, S.; Buchmann, B.; Konovalov, I.; Beekman, M.

2009-04-01

The GEOMON (Global Earth Observation and MONitoring) project has produced a harmonised data set of trace gases from various ground-based measurement stations. These stations belong to a variety of regional, national and European air quality networks (e.g. EMEP, GAW). Investigations into instrumental calibration and data quality have been carried out in order to make comparison between the sites as accurate as possible for a long time-scale trend analysis. Ozone seasonal cycles at the various sites have been compared, showing characteristic cycles according to latitude, elevation, vicinity to coastal areas and pollution sources and population nearby. A de-trending of this seasonal cycle revealed long-term variations in ozone and a considerable difference between background and peak ozone trends between sites. National, European and international legislation has aimed at reducing CO and NO2 and correspondingly, reduce O3 levels over the last 20 years but the trends are not as clear cut and reveal that there is not a homogeneous reduction in these species across Europe. Splitting the data into seasonal periods and also into lower and upper concentration percentiles shows us more clearly how the species vary across Europe. There is a tendency for peak ozone levels to decrease, whilst the background levels have mostly increased. Averages, lower and upper percentiles of these species at the GEOMON stations are shown on European maps and the distribution of annual ozone trends is evaluated. Comparisons with models that estimate the lower and upper percentiles of ozone during summer overestimate ozone levels but not uniformly across Europe.

Study on generation investment decision-making considering multi-agent benefit for global energy internet

NASA Astrophysics Data System (ADS)

Li, Pai; Huang, Yuehui; Jia, Yanbing; Liu, Jichun; Niu, Yi

2018-02-01

Abstract . This article has studies on the generation investment decision in the background of global energy interconnection. Generation investment decision model considering the multiagent benefit is proposed. Under the back-ground of global energy Interconnection, generation investors in different clean energy base not only compete with other investors, but also facing being chosen by the power of the central area, therefor, constructing generation investment decision model considering multiagent benefit can be close to meet the interests demands. Using game theory, the complete information game model is adopted to solve the strategies of different subjects in equilibrium state.

Global Learning for Global Colleges: Creating Opportunities for Greater Access to International Learning for 16-25 Year Olds

ERIC Educational Resources Information Center

Bentall, Clare; Bourn, Douglas; McGough, Hannah; Hodgson, Ann; Spours, Ken

2014-01-01

This article explores the extent to which it is possible to incorporate global learning within the further education (FE) curriculum, drawing on the findings from the "Global Learning for Global Colleges" (2009-2012) research and development project, funded by the Department for International Development (DfID). Against a background of…

Developments in Impact Assessment in North America

EPA Science Inventory

Beginning with a background of recent global developments in this area, this presentation will focus on how global research has impacted North America and how North America is providing additional developments to address the issues of the global economy. Recent developments inc...

Global Warming and Ozone Layer Depletion: STS Issues for Social Studies Classrooms.

ERIC Educational Resources Information Center

Rye, James A.; Strong, Donna D.; Rubba, Peter A.

2001-01-01

Explores the inclusion of science-technology-society (STS) education in social studies. Provides background information on global warming and the depletion of the ozone layer. Focuses on reasons for teaching global climate change in the social studies classroom and includes teaching suggestions. Offers a list of Web sites about global climate…

Exploring Global Competence with Managers in India, Japan, and the Netherlands: A Qualitative Study

ERIC Educational Resources Information Center

Ras, Gerard J. M.

2011-01-01

This qualitative study explores the meaning of global competence for global managers in three different countries. Thirty interviews were conducted with global managers in India, Japan and the Netherlands through Skype, an internet based software. Findings are reported by country in five major categories: country background, personal…

Indirect Effects of Global Change: From Physiological and Behavioral Mechanisms to Ecological Consequences.

PubMed

Gunderson, Alex R; Tsukimura, Brian; Stillman, Jonathon H

2017-07-01

A major focus of current ecological research is to understand how global change makes species vulnerable to extirpation. To date, mechanistic ecophysiological analyses of global change vulnerability have focused primarily on the direct effects of changing abiotic conditions on whole-organism physiological traits, such as metabolic rate, locomotor performance, cardiac function, and critical thermal limits. However, species do not live in isolation within their physical environments, and direct effects of climate change are likely to be compounded by indirect effects that result from altered interactions with other species, such as competitors and predators. The Society for Integrative and Comparative Biology 2017 Symposium "Indirect Effects of Global Change: From Physiological and Behavioral Mechanisms to Ecological Consequences" was designed to synthesize multiple approaches to investigating the indirect effects of global change by bringing together researchers that study the indirect effects of global change from multiple perspectives across habitat, type of anthropogenic change, and level of biological organization. Our goal in bringing together researchers from different backgrounds was to foster cross-disciplinary insights into the mechanistic bases and higher-order ecological consequences of indirect effects of global change, and to promote collaboration among fields. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Background Mole Fractions of Hydrocarbons in North America Determined from NOAA Global Reference Network Data

NASA Astrophysics Data System (ADS)

Mielke-Maday, I.

2015-12-01

The National Oceanic and Atmospheric Administration (NOAA) Global Monitoring Division (GMD) maintains a global reference network for over 50 trace gas species and analyzes discrete air samples collected by this network throughout the world at the Earth System Research Laboratory in Boulder, Colorado. In particular, flask samples are analyzed for a number of hydrocarbons with policy and health relevance such as ozone precursors, greenhouse gases, and hazardous air pollutants. Because this global network's sites are remote and therefore minimally influenced by local anthropogenic emissions, these data yield information about background ambient mole fractions and can provide a context for observations collected in intensive field campaigns, such as the Front Range Air Pollution and Photochemistry Experiment (FRAPPE), the Southeast Nexus (SENEX) study, and the DISCOVER-AQ deployments. Information about background mole fractions during field campaigns is critical for calculating hydrocarbon enhancements in the region of study and for assessing the extent to which a particular region's local emissions sources contribute to these enhancements. Understanding the geographic variability of the background and its contribution to regional ambient mole fractions is also crucial for the development of realistic regulations. We present background hydrocarbon mole fractions and their ratios in North America using data from air samples collected in the planetary boundary layer at tall towers and aboard aircraft from 2008 to 2014. We discuss the spatial and seasonal variability in these data. We present trends over the time period of measurements and propose possible explanations for these trends.

Impacts of Central American Fires on Ozone Air Quality in Texas

NASA Astrophysics Data System (ADS)

Wang, S. C.; Wang, Y.; Lei, R.; Talbot, R. W.

2016-12-01

Background ozone represents the portion of ozone level in one day that cannot be reduced by local emission controls. One of the important factors causing high background ozone events is wildfires. Satellite observations have documented frequent transport of wildfire smoke from Mexico and Central America to the southern US, particularly Texas, causing haze and exceedance of fine particle matters. However, the impact of those fires on background ozone in Texas is poorly understood. In this study, the effects of the Central America fire emissions in spring (Apr-May) from 2000 to 2013 on high background ozone events in Texas are investigated and quantified. We first examine through back trajectory analysis if any high background ozone days in cities of Texas such as Houston can be traced back to fire events in Central America. The GEOS-Chem global chemical transport model and its nested-grid version over North America are used to simulate the periods of the selected cases studies of Central American fires. Long-large transport of gaseous emissions (NOx, VOCs, and CO) from Central American fires are simulated and background ozone concentrations variations in Texas region due to those fire events are also quantified through the difference in model results with and without fire emissions in Central America. Finally, this study connects those fires and high background ozone events, and also quantifies the contribution of fire emissions from Central America on Texas ozone air quality.

Forecast and analysis of the ratio of electric energy to terminal energy consumption for global energy internet

NASA Astrophysics Data System (ADS)

Wang, Wei; Zhong, Ming; Cheng, Ling; Jin, Lu; Shen, Si

2018-02-01

In the background of building global energy internet, it has both theoretical and realistic significance for forecasting and analysing the ratio of electric energy to terminal energy consumption. This paper firstly analysed the influencing factors of the ratio of electric energy to terminal energy and then used combination method to forecast and analyse the global proportion of electric energy. And then, construct the cointegration model for the proportion of electric energy by using influence factor such as electricity price index, GDP, economic structure, energy use efficiency and total population level. At last, this paper got prediction map of the proportion of electric energy by using the combination-forecasting model based on multiple linear regression method, trend analysis method, and variance-covariance method. This map describes the development trend of the proportion of electric energy in 2017-2050 and the proportion of electric energy in 2050 was analysed in detail using scenario analysis.

Cosmological backreaction within the Szekeres model and emergence of spatial curvature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bolejko, Krzysztof, E-mail: krzysztof.bolejko@sydney.edu.au

This paper discusses the phenomenon of backreaction within the Szekeres model. Cosmological backreaction describes how the mean global evolution of the Universe deviates from the Friedmannian evolution. The analysis is based on models of a single cosmological environment and the global ensemble of the Szekeres models (of the Swiss-Cheese-type and Styrofoam-type). The obtained results show that non-linear growth of cosmic structures is associated with the growth of the spatial curvature Ω{sub R} (in the FLRW limit Ω{sub R} → Ω {sub k} ). If averaged over global scales the result depends on the assumed global model of the Universe. Withinmore » the Swiss-Cheese model, which does have a fixed background, the volume average follows the evolution of the background, and the global spatial curvature averages out to zero (the background model is the ΛCDM model, which is spatially flat). In the Styrofoam-type model, which does not have a fixed background, the mean evolution deviates from the spatially flat ΛCDM model, and the mean spatial curvature evolves from Ω{sub R} =0 at the CMB to Ω{sub R} ∼ 0.1 at 0 z =. If the Styrofoam-type model correctly captures evolutionary features of the real Universe then one should expect that in our Universe, the spatial curvature should build up (local growth of cosmic structures) and its mean global average should deviate from zero (backreaction). As a result, this paper predicts that the low-redshift Universe should not be spatially flat (i.e. Ω {sub k} ≠ 0, even if in the early Universe Ω {sub k} = 0) and therefore when analysing low- z cosmological data one should keep Ω {sub k} as a free parameter and independent from the CMB constraints.« less

Cosmological backreaction within the Szekeres model and emergence of spatial curvature

NASA Astrophysics Data System (ADS)

Bolejko, Krzysztof

2017-06-01

This paper discusses the phenomenon of backreaction within the Szekeres model. Cosmological backreaction describes how the mean global evolution of the Universe deviates from the Friedmannian evolution. The analysis is based on models of a single cosmological environment and the global ensemble of the Szekeres models (of the Swiss-Cheese-type and Styrofoam-type). The obtained results show that non-linear growth of cosmic structures is associated with the growth of the spatial curvature ΩScript R (in the FLRW limit ΩScript R → Ωk). If averaged over global scales the result depends on the assumed global model of the Universe. Within the Swiss-Cheese model, which does have a fixed background, the volume average follows the evolution of the background, and the global spatial curvature averages out to zero (the background model is the ΛCDM model, which is spatially flat). In the Styrofoam-type model, which does not have a fixed background, the mean evolution deviates from the spatially flat ΛCDM model, and the mean spatial curvature evolves from ΩScript R =0 at the CMB to ΩScript R ~ 0.1 at 0z =. If the Styrofoam-type model correctly captures evolutionary features of the real Universe then one should expect that in our Universe, the spatial curvature should build up (local growth of cosmic structures) and its mean global average should deviate from zero (backreaction). As a result, this paper predicts that the low-redshift Universe should not be spatially flat (i.e. Ωk ≠ 0, even if in the early Universe Ωk = 0) and therefore when analysing low-z cosmological data one should keep Ωk as a free parameter and independent from the CMB constraints.

Understanding how and why health is integrated into foreign policy - a case study of health is global, a UK Government Strategy 2008–2013

PubMed Central

2013-01-01

Background Over the past decade, global health issues have become more prominent in foreign policies at the national level. The process to develop state level global health strategies is arguably a form of global health diplomacy (GHD). Despite an increase in the volume of secondary research and analysis in this area, little primary research, particularly that which draws directly on the perspectives of those involved in these processes, has been conducted. This study seeks to fill this knowledge gap through an empirical case study of Health is Global: A UK Government Strategy 2008–2013. It aims to build understanding about how and why health is integrated into foreign policy and derive lessons of potential relevance to other nations interested in developing whole-of-government global health strategies. Methods The major element of the study consisted of an in-depth investigation and analysis of the UK global health strategy. Document analysis and twenty interviews were conducted. Data was organized and described using an adapted version of Walt and Gilson’s policy analysis triangle. A general inductive approach was used to identify themes in the data, which were then analysed and interpreted using Fidler’s health and foreign policy conceptualizations and Kingdon’s multiples streams model of the policymaking process. Results The primary reason that the UK decided to focus more on global health is self-interest - to protect national and international security and economic interests. Investing in global health was also seen as a way to enhance the UK’s international reputation. A focus on global health to primarily benefit other nations and improve global health per se was a prevalent through weaker theme. A well organized, credible policy community played a critical role in the process and a policy entrepreneur with expertise in both international relations and health helped catalyze attention and action on global health when the time was right. Support from the Prime Minister and from the Foreign and Commonwealth Office was essential. The process to arrive at a government-wide strategy was complex and time-consuming, but also broke down silos. Significant negotiation and compromise were required from actors with widely varying perspectives on global health and conflicting priorities. Conclusions As primarily an exploratory study, this research sheds significant light on the global health policymaking process at the level of the state. It provides a useful and important starting point for further hypothesis driven empirical research that focuses on the integration of health in foreign policy, how and why this happens and whether or not it makes an impact on improving global health. PMID:23742130

Impact of volcanic aerosols on stratospheric ozone recovery

NASA Astrophysics Data System (ADS)

Naik, Vaishali; Horowitz, Larry W.; Daniel Schwarzkopf, M.; Lin, Meiyun

2017-09-01

We use transient GFDL-CM3 chemistry-climate model simulations over the 2006-2100 period to show how the influence of volcanic aerosols on the extent and timing of ozone recovery varies with (a) future greenhouse gas scenarios (Representative Concentration Pathway (RCP)4.5 and RCP8.5) and (b) halogen loading. Current understanding is that elevated volcanic aerosols reduce ozone under high halogen loading but increase ozone under low halogen loading when the chemistry is more NOx dominated. With extremely low aerosol loadings (designated here as "background"), global stratospheric ozone burden is simulated to return to 1980 levels around 2050 in the RCP8.5 scenario but remains below 1980 levels throughout the 21st century in the RCP4.5 scenario. In contrast, with elevated volcanic aerosols, ozone column recovers more quickly to 1980 levels, with recovery dates ranging from the mid-2040s in RCP8.5 to the mid-2050s to early 2070s in RCP4.5. The ozone response in both future emission scenarios increases with enhanced volcanic aerosols. By 2100, the 1980 baseline-adjusted global stratospheric ozone column is projected to be 20-40% greater in RCP8.5 and 110-200% greater in RCP4.5 with elevated volcanic aerosols compared to simulations with the extremely low background aerosols. The weaker ozone enhancement at 2100 in RCP8.5 than in RCP4.5 in response to elevated volcanic aerosols is due to a factor of 2.5 greater methane in RCP8.5 compared with RCP4.5. Our results demonstrate the substantial uncertainties in stratospheric ozone projections and expected recovery dates induced by volcanic aerosol perturbations that need to be considered in future model ozone projections.

Biodiversity of the Great Barrier Reef—how adequately is it protected?

PubMed Central

2018-01-01

Background The Great Barrier Reef (GBR) is the world’s most iconic coral reef ecosystem, recognised internationally as a World Heritage Area of outstanding significance. Safeguarding the biodiversity of this universally important reef is a core legislative objective; however, ongoing cumulative impacts including widespread coral bleaching and other detrimental impacts have heightened conservation concerns for the future of the GBR. Methods Here we review the literature to report on processes threatening species on the GBR, the status of marine biodiversity, and evaluate the extent of species-level monitoring and reporting. We assess how many species are listed as threatened at a global scale and explore whether these same species are protected under national threatened species legislation. We conclude this review by providing future directions for protecting potentially endangered elements of biodiversity within the GBR. Results Most of the threats identified to be harming the diversity of marine life on the GBR over the last two–three decades remain to be effectively addressed and many are worsening. The inherent resilience of this globally significant coral reef ecosystem has been seriously compromised and various elements of the biological diversity for which it is renowned may be at risk of silent extinction. We show at least 136 of the 12,000+ animal species known to occur on the GBR (approximately 20% of the 700 species assessed by the IUCN) occur in elevated categories of threat (Critically Endangered, Endangered or Vulnerable) at a global scale. Despite the wider background level of threat for these 136 species, only 23 of them are listed as threatened under regional or national legislation. Discussion To adequately protect the biodiversity values of the GBR, it may be necessary to conduct further targeted species-level monitoring and reporting to complement ecosystem management approaches. Conducting a vigorous value of information analysis would provide the opportunity to evaluate what new and targeted information is necessary to support dynamic management and to safeguard both species and the ecosystem as a whole. Such an analysis would help decision-makers determine if further comprehensive biodiversity surveys are needed, especially for those species recognised to be facing elevated background levels of threat. If further monitoring is undertaken, it will be important to ensure it aligns with and informs the GBRMPA Outlook five-year reporting schedule. The potential also exists to incorporate new environmental DNA technologies into routine monitoring to deliver high-resolution species data and identify indicator species that are cursors of specific disturbances. Unless more targeted action is taken to safeguard biodiversity, we may fail to pass onto future generations many of the values that comprise what is universally regarded as the world’s most iconic coral reef ecosystem. PMID:29761059

A Flexible Cosmic Ultraviolet Background Model

NASA Astrophysics Data System (ADS)

McQuinn, Matthew

2016-10-01

HST studies of the IGM, of the CGM, and of reionization-era galaxies are all aided by ionizing background models, which are a critical input in modeling the ionization state of diffuse, 10^4 K gas. The ionization state in turn enables the determination of densities and sizes of absorbing clouds and, when applied to the Ly-a forest, the global ionizing emissivity of sources. Unfortunately, studies that use these background models have no way of gauging the amount of uncertainty in the adopted model other than to recompute their results using previous background models with outdated observational inputs. As of yet there has been no systematic study of uncertainties in the background model and there unfortunately is no publicly available ultraviolet background code. A public code would enable users to update the calculation with the latest observational constraints, and it would allow users to experiment with varying the background model's assumptions regarding emissions and absorptions. We propose to develop a publicly available ionizing background code and, as an initial application, quantify the level of uncertainty in the ionizing background spectrum across cosmic time. As the background model improves, so does our understanding of (1) the sources that dominate ionizing emissions across cosmic time and (2) the properties of diffuse gas in the circumgalactic medium, the WHIM, and the Ly-a forest. HST is the primary telescope for studying both the highest redshift galaxies and low-redshift diffuse gas. The proposed program would benefit HST studies of the Universe at z 0 all the way up to z = 10, including of high-z galaxies observed in the HST Frontier Fields.

Greenhouse Gas-ette Fall 1988, Spring, Fall 1989, Winter, Spring, Fall 1990.

ERIC Educational Resources Information Center

Greenhouse Gas-ette, 1990

1990-01-01

This newsletter is for educators interested in developing lessons related to global climate change. The newsletter contains sample lessons, news items involving global climate change on an international scale, and background information on issues related to global climate change. (CW)

Building Global Learning Communities

ERIC Educational Resources Information Center

Cochrane, Thomas; Buchem, Ilona; Camacho, Mar; Cronin, Catherine; Gordon, Averill; Keegan, Helen

2013-01-01

Within the background where education is increasingly driven by the economies of scale and research funding, we propose an alternative online open and connected framework (OOC) for building global learning communities using mobile social media. We critique a three year action research case study involving building collaborative global learning…

Effectiveness of carbon dioxide removal in lowering atmospheric CO2 and reversing global warming in the context of 1.5 degrees

NASA Astrophysics Data System (ADS)

Zickfeld, K.; Azevedo, D.

2017-12-01

The majority of emissions scenarios that limit warming to 2°C, and nearly all emission scenarios that do not exceed 1.5°C warming by the year 2100 require artificial removal of CO2 from the atmosphere. Carbon dioxide removal (CDR) technologies in these scenarios are required to offset emissions from sectors that are difficult or costly to decarbonize and to generate global `net negative' emissions, allowing to compensate for earlier emissions and to meet long-term climate stabilization targets after overshoot. Only a few studies have explored the Earth system response to CDR and large uncertainties exist regarding the effect of CDR on the carbon cycle and its effectiveness in reversing climate impacts after overshoot. Here we explore the effectiveness of CDR in lowering atmospheric CO2 ("carbon cycle effectiveness") and cool global climate ("cooling effectiveness"). We force the University of Victoria Earth System Climate Model, a model of intermediate complexity, with a set of negative CO2 emissions pulses of different magnitude and applied from different background atmospheric CO2 concentrations. We find the carbon cycle effectiveness of CDR - defined as the change in atmospheric CO2 per unit CO2 removed - decreases with the amount of CO2 removed from the atmosphere and increases at higher background CO2 concentrations from which CDR is applied due to nonlinear responses of carbon sinks to CO2 and climate. The cooling effectiveness - defined as the change in global mean surface air temperature per unit CO2 removed - on the other hand, is largely insensitive to the amount of CO2 removed, but decreases if CDR is applied at higher atmospheric CO2 concentrations, due to the logarithmic relationship between atmospheric CO2 and radiative forcing. Based on our results we conclude that CDR is more effective in restoring a lower atmospheric CO2 concentration and reversing impacts directly linked to CO2 at lower levels of overshoot. CDR's effectiveness in restoring a cooler climate, on the other hand, is largely insensitive to the level of overshoot.

Characteristics of Quasi-Biennial Oscillation simulation in the Meteorological Research Institute earth system model

NASA Astrophysics Data System (ADS)

Yoshida, K.; Naoe, H.

2016-12-01

Whether climate models drive Quasi-Biennial Oscillation (QBO) appropriately is important to assess QBO impact on climate change such as global warming and solar related variation. However, there were few models generating QBO in the Coupled Model Intercomparison Project Phase 5 (CMIP5). This study focuses on dynamical structure of the QBO and its sensitivity to background wind pattern and model configuration. We present preliminary results of experiments designed by "Towards Improving the QBO in Global Climate Models (QBOi)", which is derived from the Stratosphere-troposphere processes and their role in climate (SPARC), in the Meteorological Research Institute earth system model, MRI-ESM2. The simulations were performed in present-day climate condition, repeated annual cycle condition with various CO2 level and sea surface temperatures, and QBO hindcast. In the present climate simulation, zonal wind in the equatorial stratosphere generally exhibits realistic behavior of the QBO. Equatorial zonal wind variability associated with QBO is overestimated in upper stratosphere and underestimated in lower stratosphere. In the MRI-ESM2, the QBO behavior is mainly driven by gravity wave drag parametrization (GWDP) introduced in Hines (1997). Comparing to reanalyses, shortage of resolved wave forcing is found especially in equatorial lower stratosphere. These discrepancies can be attributed to difference in wave forcing, background wind pattern and model configuration. We intend to show results of additional sensitivity experiments to examine how model configuration and background wind pattern affect resolved wave source, wave propagation characteristics, and QBO behavior.

Global manipulation of digital images can lead to variation in cytological diagnosis

PubMed Central

Prasad, H; Wanjari, Sangeeta; Parwani, Rajkumar

2011-01-01

Background: With the adoption of a completely electronic workflow by several journals and the advent of telepathology, digital imaging has become an integral part of every scientific research. However, manipulating digital images is very easy, and it can lead to misinterpretations. Aim: To analyse the impact of manipulating digital images on their diagnosis. Design: Digital images were obtained from Papanicolaou-stained smears of dysplastic and normal oral epithelium. They were manipulated using GNU Image Manipulation Program (GIMP) to alter their brightness and contrast and color levels. A Power Point presentation composed of slides of these manipulated images along with the unaltered originals arranged randomly was created. The presentation was shown to five observers individually who rated the images as normal, mild, moderate or severe dysplasia. Weighted κ statistics was used to measure and assess the levels of agreement between observers. Results: Levels of agreement between manipulated images and original images varied greatly among observers. Variation in diagnosis was in the form of overdiagnosis or under-diagnosis, usually by one grade. Conclusion: Global manipulations of digital images of cytological slides can significantly affect their interpretation. Such manipulations should therefore be kept to a minimum, and avoided wherever possible. PMID:21572507

Microplastics in the Ocean.

PubMed

Shim, Won Joon; Thomposon, Richard C

2015-10-01

Since their ubiquity in the ocean and marine organisms was first revealed, global concern about microplastics has grown considerably. The North Pacific Ocean and the adjacent marginal seas have high levels of microplastic contamination compared with the global average. This special issue on microplastics was organized by the North Pacific Marine Science Organization to share information on microplastic pollution in the North Pacific region. The special issue highlights high levels of contamination in the North Pacific both on shorelines and at the sea surface. Particularly high levels of contamination were reported on the western and southern coasts of Korea. Sources, including sewage discharge, aquaculture, and shipyards, were implicated. With the direction and energy of surface winds and currents have an important influence on shoreline patterns of distribution. The special issue also demonstrates potential for ingestion of microplastic by small planktonic organisms at the base of the food chain. A wide range of chemicals are associated with plastic debris and concerns are expressed about the potential for these chemicals to transfer to biota upon ingestion. As an introduction to the topic, this paper provides a brief background on microplastic contamination, highlights some key research gaps, and summarizes findings from the articles published in this issue.

Recent changes in stratospheric aerosol budget from ground-based and satellite observations

NASA Astrophysics Data System (ADS)

Khaykin, Sergey; Godin-Beekmann, Sophie; Keckhut, Philippe; Hauchecorne, Alain; Portafaix, Thierry; Begue, Nelson; Vernier, Jean-Paul; DeLand, Matthew; Bhartia, Pawan K.; Leblanc, Thierry

2017-04-01

Stratospheric aerosol budget plays an important role in climate variability and ozone chemistry. Observations of stratospheric aerosol by ground-based lidars represent a particular value as they ensure the continuity and coherence of stratospheric aerosol record. Ground-based lidars remain indispensable for complementing and validating satellite instruments and for filling gaps between satellite missions. On the other hand, geophysical interpretation of local observations is complicated without the knowledge of global distribution of stratospheric aerosol, which calls for a combined analysis of ground-based and space-borne observations. The present study aims at characterizing global and regional variability of stratospheric aerosol over the last 5 years using various sets of observations. We use the data provided by three lidars operated within NDACC (Network for Detection of Atmospheric Composition Change) at Haute-Provence, (44° N), Mauna Loa (21° N) and Maido (21° S) sites together with quasi-global-coverage aerosol measurements by CALIOP and OMPS satellite instruments. The local and space-borne measurements are shown to be in good agreement allowing for their synergetic use. Since the late 2012 stratospheric aerosol remained at background levels throughout the globe. Eruptions of Kelud volcano at 4° S in February 2014 and Calbuco volcano at 41° S in April 2015 resulted in a remarkable enhancement of stratospheric AOD at a wide latitude range. We explore meridional dispersion and lifetime of volcanic plumes in consideration of global atmospheric circulation. A focus is made on the poleward transport of volcanic aerosol and its detection at the mid-latitude Haute-Provence observatory. We show that the moderate eruptions in the Southern hemisphere leave a measurable imprint on the Northern mid-latitude aerosol loading. Having identified the volcanically-perturbed periods from local and global observations we examine the evolution of non-volcanic (background) aerosol by comparing the recent observations with historical data available from 23-yr observations at Haute-Provence and Mauna-Loa.

Analyzing Personal Happiness from Global Survey and Weather Data: A Geospatial Approach.

PubMed

Peng, Yi-Fan; Tang, Jia-Hong; Fu, Yang-chih; Fan, I-chun; Hor, Maw-Kae; Chan, Ta-Chien

2016-01-01

Past studies have shown that personal subjective happiness is associated with various macro- and micro-level background factors, including environmental conditions, such as weather and the economic situation, and personal health behaviors, such as smoking and exercise. We contribute to this literature of happiness studies by using a geospatial approach to examine both macro and micro links to personal happiness. Our geospatial approach incorporates two major global datasets: representative national survey data from the International Social Survey Program (ISSP) and corresponding world weather data from the National Oceanic and Atmospheric Administration (NOAA). After processing and filtering 55,081 records of ISSP 2011 survey data from 32 countries, we extracted 5,420 records from China and 25,441 records from 28 other countries. Sensitivity analyses of different intervals for average weather variables showed that macro-level conditions, including temperature, wind speed, elevation, and GDP, are positively correlated with happiness. To distinguish the effects of weather conditions on happiness in different seasons, we also adopted climate zone and seasonal variables. The micro-level analysis indicated that better health status and eating more vegetables or fruits are highly associated with happiness. Never engaging in physical activity appears to make people less happy. The findings suggest that weather conditions, economic situations, and personal health behaviors are all correlated with levels of happiness.

Opportunities drive the global distribution of protected areas

PubMed Central

Texeira, Marcos; Martin, Osvaldo A.; Grau, H. Ricardo; Jobbágy, Esteban G.

2017-01-01

Background Protected areas, regarded today as a cornerstone of nature conservation, result from an array of multiple motivations and opportunities. We explored at global and regional levels the current distribution of protected areas along biophysical, human, and biological gradients, and assessed to what extent protection has pursued (i) a balanced representation of biophysical environments, (ii) a set of preferred conditions (biological, spiritual, economic, or geopolitical), or (iii) existing opportunities for conservation regardless of any representation or preference criteria. Methods We used histograms to describe the distribution of terrestrial protected areas along biophysical, human, and biological independent gradients and linear and non-linear regression and correlation analyses to describe the sign, shape, and strength of the relationships. We used a random forest analysis to rank the importance of different variables related to conservation preferences and opportunity drivers, and an evenness metric to quantify representativeness. Results We find that protection at a global level is primarily driven by the opportunities provided by isolation and a low population density (variable importance = 34.6 and 19.9, respectively). Preferences play a secondary role, with a bias towards tourism attractiveness and proximity to international borders (variable importance = 12.7 and 3.4, respectively). Opportunities shape protection strongly in “North America & Australia–NZ” and “Latin America & Caribbean,” while the importance of the representativeness of biophysical environments is higher in “Sub-Saharan Africa” (1.3 times the average of other regions). Discussion Environmental representativeness and biodiversity protection are top priorities in land conservation agendas. However, our results suggest that they have been minor players driving current protection at both global and regional levels. Attempts to increase their relevance will necessarily have to recognize the predominant opportunistic nature that the establishment of protected areas has had until present times. PMID:28229022

Reflections on the ethics of recruiting foreign-trained human resources for health

PubMed Central

2011-01-01

Background Developed countries' gains in health human resources (HHR) from developing countries with significantly lower ratios of health workers have raised questions about the ethics or fairness of recruitment from such countries. By attracting and/or facilitating migration for foreign-trained HHR, notably those from poorer, less well-resourced nations, recruitment practices and policies may be compromising the ability of developing countries to meet the health care needs of their own populations. Little is known, however, about actual recruitment practices. In this study we focus on Canada (a country with a long reliance on internationally trained HHR) and recruiters working for Canadian health authorities. Methods We conducted interviews with health human resources recruiters employed by Canadian health authorities to describe their recruitment practices and perspectives and to determine whether and how they reflect ethical considerations. Results and discussion We describe the methods that recruiters used to recruit foreign-trained health professionals and the systemic challenges and policies that form the working context for recruiters and recruits. HHR recruiters' reflections on the global flow of health workers from poorer to richer countries mirror much of the content of global-level discourse with regard to HHR recruitment. A predominant market discourse related to shortages of HHR outweighed discussions of human rights and ethical approaches to recruitment policy and action that consider global health impacts. Conclusions We suggest that the concept of corporate social responsibility may provide a useful approach at the local organizational level for developing policies on ethical recruitment. Such local policies and subsequent practices may inform public debate on the health equity implications of the HHR flows from poorer to richer countries inherent in the global health worker labour market, which in turn could influence political choices at all government and health system levels. PMID:21251293

Phobic Anxiety and Plasma Levels of Global Oxidative Stress in Women

PubMed Central

Hagan, Kaitlin A.; Wu, Tianying; Rimm, Eric B.; Eliassen, A. Heather; Okereke, Olivia I.

2015-01-01

Background and Objectives Psychological distress has been hypothesized to be associated with adverse biologic states such as higher oxidative stress and inflammation. Yet, little is known about associations between a common form of distress – phobic anxiety – and global oxidative stress. Thus, we related phobic anxiety to plasma fluorescent oxidation products (FlOPs), a global oxidative stress marker. Methods We conducted a cross-sectional analysis among 1,325 women (aged 43-70 years) from the Nurses’ Health Study. Phobic anxiety was measured using the Crown-Crisp Index (CCI). Adjusted least-squares mean log-transformed FlOPs were calculated across phobic categories. Logistic regression models were used to calculate odds ratios (OR) comparing the highest CCI category (≥6 points) vs. lower scores, across FlOPs quartiles. Results No association was found between phobic anxiety categories and mean FlOP levels in multivariable adjusted linear models. Similarly, in multivariable logistic regression models there were no associations between FlOPs quartiles and likelihood of being in the highest phobic category. Comparing women in the highest vs. lowest FlOPs quartiles: FlOP_360: OR=0.68 (95% CI: 0.40-1.15); FlOP_320: OR=0.99 (95% CI: 0.61-1.61); FlOP_400: OR=0.92 (95% CI: 0.52, 1.63). Conclusions No cross-sectional association was found between phobic anxiety and a plasma measure of global oxidative stress in this sample of middle-aged and older women. PMID:26635425

Origin of malaria cases: a 7-year audit of global trends in indigenous and imported cases in relation to malaria elimination

PubMed Central

Velarde-Rodríguez, Mar; Van den Bergh, Rafael; Fergus, Cristin; Casellas, Aina; Sanz, Sergi; Cibulskis, Richard; Ramsay, Andrew R.; Bissell, Karen; Zachariah, Rony

2015-01-01

Background Countries in the different stages of pre-elimination, elimination, and prevention of reintroduction are required to report the number of indigenous and imported malaria cases to the World Health Organization (WHO). However, these data have not been systematically analysed at the global level. Objective For the period 2007 to 2013, we aimed to report on 1) the proportion of countries providing data on the origin of malaria cases and 2) the origin of malaria cases in countries classified as being in the stages of pre-elimination, elimination and prevention of reintroduction. Design An observational study using annual data reported through routine health information systems to the WHO Global Malaria Programme between 2007 and 2013. Results For all countries classified as being in pre-elimination, elimination, and prevention of reintroduction in the year 2013, there has been a substantial decrease in the total number of indigenous malaria cases, from more than 15,000 cases reported in 2007 to less than 4,000 cases reported in 2013. However, the total number of imported malaria cases has increased over that time period, from 5,600 imported cases in 2007 to approximately 6,800 in 2013. Conclusions Vigilant monitoring of the numbers of imported and indigenous malaria cases at national and global levels as well as appropriate strategies to target these cases will be critical to achieve malaria eradication. PMID:26449205

Periodicity in marine extinction events

NASA Technical Reports Server (NTRS)

Sepkoski, J. John, Jr.; Raup, David M.

1986-01-01

The periodicity of extinction events is examined in detail. In particular, the temporal distribution of specific, identifiable extinction events is analyzed. The nature and limitations of the data base on the global fossil record is discussed in order to establish limits of resolution in statistical analyses. Peaks in extinction intensity which appear to differ significantly from background levels are considered, and new analyses of the temporal distribution of these peaks are presented. Finally, some possible causes of periodicity and of interdependence among extinction events over the last quarter billion years of earth history are examined.

Ozone, Climate, and Global Atmospheric Change.

ERIC Educational Resources Information Center

Levine, Joel S.

1992-01-01

Presents an overview of global atmospheric problems relating to ozone depletion and global warming. Provides background information on the composition of the earth's atmosphere and origin of atmospheric ozone. Describes causes, effects, and evidence of ozone depletion and the greenhouse effect. A vignette provides a summary of a 1991 assessment of…

Developing Intercultural Competence through Global Link Experiences in Physical Education

ERIC Educational Resources Information Center

Ko, Bomna; Boswell, Boni; Yoon, Seok

2015-01-01

Background: Recognition of the importance of the development of intercultural competence (ICC) has placed intense pressure on teacher education programs to infuse a global perspective into their programs. Several studies have proposed integration of global elements into teacher education programs. Although the use of online tools for…

Aquarius Instrument Science Calibration During the Risk Reduction Phase

NASA Technical Reports Server (NTRS)

Ruf, Christopher S.

2004-01-01

This final report presents the results of work performed under NASA Grant NAG512726 during the period 15 January 2003 through 30 June 2004. An analysis was performed of a possible vicarious calibration method for use by Aquarius to monitor and stabilize the absolute and relative calibration of its microwave radiometer. Stationary statistical properties of the brightness temperature (T(sub B)) measured by a low Earth orbiting radiometer operating at 1.4135 GHz are considered as a means of validating its absolute calibration. The global minimum, maximum, and average T(sub B) are considered, together with a vicarious cold reference method that detects the presence of a sharp lower bound on naturally occurring values for T(sub B). Of particular interest is the reliability with which these statistics can be extracted from a realistic distribution of T(sub B) measurements that would be observed by a typical sensor. Simulations of measurements are performed that include the effects of instrument noise and variable environmental factors such as the global water vapor and ocean surface temperature, salinity and wind distributions. Global minima can vary widely due to instrument noise and are not a reliable calibration reference. Global maxima are strongly influenced by several environmental factors as well as instrument noise and are even less stationary. Global averages are largely insensitive to instrument noise and, in most cases, to environmental conditions as well. The global average T(sub B) varies at only the 0.1 K RMS level except in cases of anomalously high winds, when it can increase considerably more. The vicarious cold reference is similarly insensitive to instrument effects and most environmental factors. It is not significantly affected by high wind conditions. The stability of the vicarious reference is, however, found to be somewhat sensitive (at the several tenths of Kelvins level) to variations in the background cold space brightness, T(sub c). The global average is much less sensitive to this parameter and so using two approaches together can be mutually beneficial.

Assessment of natural background radiation in one of the highest regions of Ecuador

NASA Astrophysics Data System (ADS)

Pérez, Mario; Chávez, Estefanía; Echeverría, Magdy; Córdova, Rafael; Recalde, Celso

2018-05-01

Natural background radiation was measured in the province of Chimborazo (Ecuador) with the following reference coordinates 1°40'00''S 78°39'00''W, where the furthest point to the center of the planet is located. Natural background radiation measurements were performed at 130 randomly selected sites using a Geiger Müller GCA-07W portable detector; these measurements were run at 6 m away from buildings or walls and 1 m above the ground. The global average natural background radiation established by UNSCEAR is 2.4 mSv y-1. In the study area measurements ranged from 0.57 mSv y-1 to 3.09 mSv y-1 with a mean value of 1.57 mSv y-1, the maximum value was recorded in the north of the study area at 5073 metres above sea level (m.a.s.l.), and the minimum value was recorded in the southwestern area at 297 m.a.s.l. An isodose map was plotted to represent the equivalent dose rate due to natural background radiation. An analysis of variance (ANOVA) between the data of the high and low regions of the study area showed a significant difference (p < α), in addition a linear correlation coefficient of 0.92 was obtained, supporting the hypothesis that in high altitude zones extraterrestrial radiation contributes significantly to natural background radiation.

Analysis of European ozone trends in the period 1995-2014

NASA Astrophysics Data System (ADS)

Yan, Yingying; Pozzer, Andrea; Ojha, Narendra; Lin, Jintai; Lelieveld, Jos

2018-04-01

Surface-based measurements from the EMEP and Airbase networks are used to estimate the changes in surface ozone levels during the 1995-2014 period over Europe. We find significant ozone enhancements (0.20-0.59 µg m-3 yr-1 for the annual means; P-value < 0.01 according to an F-test) over the European suburban and urban stations during 1995-2012 based on the Airbase sites. For European background ozone observed at EMEP sites, it is shown that a significantly decreasing trend in the 95th percentile ozone concentrations has occurred, especially at noon (0.9 µg m-3 yr-1; P-value < 0.01), while the 5th percentile ozone concentrations continued to increase with a trend of 0.3 µg m-3 yr-1 (P-value < 0.01) during the study period. With the help of numerical simulations performed with the global chemistry-climate model EMAC, the importance of anthropogenic emissions changes in determining these changes over background sites are investigated. The EMAC model is found to successfully capture the observed temporal variability in mean ozone concentrations, as well as the contrast in the trends of 95th and 5th percentile ozone over Europe. Sensitivity simulations and statistical analysis show that a decrease in European anthropogenic emissions had contrasting effects on surface ozone trends between the 95th and 5th percentile levels and that background ozone levels have been influenced by hemispheric transport, while climate variability generally regulated the inter-annual variations of surface ozone in Europe.

Employment relations and global health: a typological study of world labor markets.

PubMed

Chung, Haejoo; Muntaner, Carles; Benach, Joan

2010-01-01

In this study, the authors investigate the global labor market and employment relations, which are central building blocks of the welfare state; the aim is to propose a global typology of labor markets to explain global inequalities in population health. Countries are categorized into core (21), semi-peripheral (42), and peripheral (71) countries, based on gross national product per capita (Atlas method). Labor market-related variables and factors are then used to generate clusters of countries with principal components and cluster analysis methods. The authors then examine the relationship between the resulting clusters and health outcomes. The clusters of countries are largely geographically defined, each cluster with similar historical background and developmental strategy. However, there are interesting exceptions, which warrant further elaboration. The relationship between health outcomes and clusters largely follows the authors' expectations (except for communicable diseases): more egalitarian labor institutions have better health outcomes. The world system, then, can be divided according to different types of labor markets that are predictive of population health outcomes at each level of economic development. As is the case for health and social policies, variability in labor market characteristics is likely to reflect, in part, the relative strength of a country's political actors.

Impact of Ocean Warming on Tropical Cyclone Size and Its Destructiveness.

PubMed

Sun, Yuan; Zhong, Zhong; Li, Tim; Yi, Lan; Hu, Yijia; Wan, Hongchao; Chen, Haishan; Liao, Qianfeng; Ma, Chen; Li, Qihua

2017-08-15

The response of tropical cyclone (TC) destructive potential to global warming is an open issue. A number of previous studies have ignored the effect of TC size change in the context of global warming, which resulted in a significant underestimation of the TC destructive potential. The lack of reliable and consistent historical data on TC size limits the confident estimation of the linkage between the observed trend in TC size and that in sea surface temperature (SST) under the background of global climate warming. A regional atmospheric model is used in the present study to investigate the response of TC size and TC destructive potential to increases in SST. The results show that a large-scale ocean warming can lead to not only TC intensification but also TC expansion. The TC size increase in response to the ocean warming is possibly attributed to the increase in atmospheric convective instability in the TC outer region below the middle troposphere, which facilitates the local development of grid-scale ascending motion, low-level convergence and the acceleration of tangential winds. The numerical results indicate that TCs will become stronger, larger, and unexpectedly more destructive under global warming.

Background concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in the global oceanic atmosphere.

PubMed

Morales, Laura; Dachs, Jordi; González-Gaya, Belén; Hernán, Gema; Abalos, Manuela; Abad, Esteban

2014-09-02

The remote oceans are among the most pristine environments in the world, away from sources of anthropogenic persistent organic pollutants (POP), but nevertheless recipients of atmospheric deposition of POPs that have undergone long-range atmospheric transport (LRAT). In this work, the background occurrence of gas and aerosol phase polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and dioxin like polychlorinated biphenyls (dl-PCB) is evaluated for the first time in the atmosphere of the tropical and subtropical Atlantic, Pacific, and Indian oceans. Thirty-nine air samples were collected during the eight-month Malaspina circumnavigation cruise onboard the R/V Hespérides. The background levels of dioxins and dl-PCBs remained very low and in many cases very close to or below the limit of detection. Expectedly, the levels of PCBs were higher than dioxins, PCB#118 being the most abundant compound. In the particular case of dioxins, octachlorodibenzo-p-dioxin (OCDD) was the most abundant PCDD/F congener. Distribution of dl-PCB is dominated by the gas phase, while for PCDD/F the aerosol phase concentrations were higher, particularly for the more hydrophobic congeners. The Atlantic Ocean presented on average the highest PCDD/F and dl-PCB concentrations, being lower in the southern hemisphere. The assessment of air mass back trajectories show a clear influence of continental source regions, and lower concentrations when the air mass has an oceanic origin. In addition, the samples affected by an oceanic air mass are characterized by a lower contribution of the less chlorinated dioxins in comparison with the furans, consistent with the reported higher reaction rate constants of dibenzo-p-dioxins with OH radicals than those of dibenzofurans. The total dry atmospheric deposition of aerosol-bound ∑PCDD/F and ∑dl-PCB to the global oceans was estimated to be 354 and 896 kg/year, respectively.

Background distraction during vertical solid and character line bisections.

PubMed

Rodriguez, Julio A; Lamb, Damon G; Salazar, Liliana; Correa, Lauren N; Mosquera, Diana M; Schwartz, Zared J; Cohen, Ronald A; Falchook, Adam D; Heilman, Kenneth M

2018-04-04

Background-objectives: When vertical lines are positioned above or below the center of the page, line bisection deviates toward the center of the page, suggesting that the edges of the page distract the allocation of attention to the line. A letter-character line (LCL) bisection requires both global and focal attention, to identify the target letter closest to the line's center. If more focal and less global attention is allocated to a LCL, more global attentional resources may be available and inadvertently allocated to the page. Alternatively, if the allocation of focal attention to a LCL inhibits global attentional processing, there may be less distraction by the page. Twenty-four healthy adults (12 older) bisected vertical solid and character lines centered, or positioned closer to the top or bottom of the page. There was no difference between bisection of solid and character lines centered on the page. Page-related deviations were greater with character lines than solid line bisections, and greater for lines positioned toward the top than the bottom of the page. With lines positioned toward the top, the older participants' attempted bisections were higher than those of the younger participants. These results suggest that the allocation of focal attention increases global attentional distractibility and that global-background attentional distraction is greater when the vertical lines are placed in the upper part of the page. Older participants appeared to be less distracted when lines were placed toward the top of the page, but the reason for this age difference requires further research.

State strategies of governance in biomedical innovation: aligning conceptual approaches for understanding 'Rising Powers' in the global context

PubMed Central

2011-01-01

Background 'Innovation' has become a policy focus in its own right in many states as they compete to position themselves in the emerging knowledge economies. Innovation in biomedicine is a global enterprise in which 'Rising Power' states figure prominently, and which undoubtedly will re-shape health systems and health economies globally. Scientific and technological innovation processes and policies raise difficult issues in the domains of science/technology, civil society, and the economic and healthcare marketplace. The production of knowledge in these fields is complex, uncertain, inter-disciplinary and inter-institutional, and subject to a continuing political struggle for advantage. As part of this struggle, a wide variety of issues - regulation, intellectual property, ethics, scientific boundaries, healthcare market formation - are raised and policy agendas negotiated. Methods A range of social science disciplines and approaches have conceptualised such innovation processes. Against a background of concepts such as the competition state and the developmental state, and national innovation systems, we give an overview of a range of approaches that have potential for advancing understanding of governance of global life science and biomedical innovation, with special reference to the 'Rising Powers', in order to examine convergences and divergences between them. Conceptual approaches that we focus on include those drawn from political science/political economy, sociology of technology; Innovation Studies and Science & Technology Studies. The paper is part of a project supported by the UK ESRC's Rising Powers programme. Results We show convergences and complementarities between the approaches discussed, and argue that the role of the national state itself has become relatively neglected in much of the relevant theorising. Conclusions We conclude that an approach is required that enables innovation and governance to be seen as 'co-producing' each other in a multi-level, global ecology of innovation, taking account of the particular, differing characteristics of different emerging scientific fields and technologies. We suggest key points to take account of in order in the future to move toward a satisfactory integrative conceptual framework, capable of better understanding the processes of the emergence, state steerage and transnational governance of innovative biomedical sectors in the Rising Powers and global context. PMID:21349182

Public Health Policy and Experience of the 2009 H1N1 Influenza Pandemic in Pune, India

PubMed Central

Purohit, Vidula; Kudale, Abhay; Sundaram, Neisha; Joseph, Saju; Schaetti, Christian; Weiss, Mitchell G.

2018-01-01

Background: Prior experience and the persisting threat of influenza pandemic indicate the need for global and local preparedness and public health response capacity. The pandemic of 2009 highlighted the importance of such planning and the value of prior efforts at all levels. Our review of the public health response to this pandemic in Pune, India, considers the challenges of integrating global and national strategies in local programmes and lessons learned for influenza pandemic preparedness. Methods: Global, national and local pandemic preparedness and response plans have been reviewed. In-depth interviews were undertaken with district health policy-makers and administrators who coordinated the pandemic response in Pune. Results: In the absence of a comprehensive district-level pandemic preparedness plan, the response had to be improvised. Media reporting of the influenza pandemic and inaccurate information that was reported at times contributed to anxiety in the general public and to widespread fear and panic. Additional challenges included inadequate public health services and reluctance of private healthcare providers to treat people with flu-like symptoms. Policy-makers developed a response strategy that they referred to as the Pune plan, which relied on powers sanctioned by the Epidemic Act of 1897 and resources made available by the union health ministry, state health department and a government diagnostic laboratory in Pune. Conclusion: The World Health Organization’s (WHO’s) global strategy for pandemic control focuses on national planning, but state-level and local experience in a large nation like India shows how national planning may be adapted and implemented. The priority of local experience and requirements does not negate the need for higher level planning. It does, however, indicate the importance of local adaptability as an essential feature of the planning process. Experience and the implicit Pune plan that emerged are relevant for pandemic preparedness and other public health emergencies. PMID:29524939

Global World: A Problem of Governance

ERIC Educational Resources Information Center

Chumakov, Alexander Nikolayevich

2014-01-01

Purpose: The purpose of this paper is to include the following items: to show the absolute necessity of managing the international community, to explore the fundamental possibility of managing the global world, to prove or disprove such a possibility, to determine the real background of global governance in modern conditions and to show the…

Globalization and Multileveled Citizenship Education: A Tale of Two Chinese Cities, Hong Kong and Shanghai

ERIC Educational Resources Information Center

Law, Wing-Wah; Ng, Ho Ming

2009-01-01

Background/Context: For centuries, the notions of citizenship and citizenship education have been associated with the nation-state and civic elements. However, since the late 20th century, these traditional notions have been challenged by globalization. In the discourse of globalization, citizenship, and citizenship education, some scholars…

Global Issues: Activities and Resources for the High School Teacher.

ERIC Educational Resources Information Center

Switzer, Kenneth A.; Mulloy, Paul T.

The book is an introduction to teaching about contemporary global concerns in the high school social studies classroom. It contains background and lesson plans for seven units in addition to 39 reproducible student handouts, annotated lists of other good classroom resources, and a guide to sources of teaching materials on global issues. Topics…

PM levels in the Basque Country (Northern Spain): analysis of a 5-year data record and interpretation of seasonal variations

NASA Astrophysics Data System (ADS)

Viana, M.; Querol, X.; Alastuey, A.; Gangoiti, G.; Menéndez, M.

Levels of PM observed at the air quality network from the Basque Country in 1996-2000 ranged from 16 μg PM 10/m 3 at regional background sites, to 35-40 μg TSP/m 3 (equivalent to 25-30 μg PM 10/m 3) at urban background sites, to 40-48 μg TSP/m 3 (30-40 μg PM 10/m 3) at roadside sites; to 50-64 μg TSP/m 3 (35-50 μg PM 10/m 3) at industrial and heavy traffic sites. The EU daily and annual PM 10 limit values for 2005 are not equivalent for the Basque Country, and consequently only the mean 1996-2000 PM levels from one station would exceed the 2005 annual limit value but most of them surpass n=35 exceedances of the daily limit value. The equivalent n to the 2005 annual limit value is around 80. Four major processes exert an influence on PM levels throughout the Basque territory: local and regional anthropogenic contributions, precipitation, African dust and European transport. PM at Llodio (an urban background site under industrial influence and mean PM 10, PM 2.5 and PM 1 levels for 2001 of 34, 25 and 21 μg/m 3) is mainly distributed in the fine mode: 74% of PM 10 is constituted by PM 2.5, and 64% of PM 2.5 presents a diameter <1 μm. The particle size distribution of PM varies seasonally with the fine fractions prevailing in summer (PM 2.5/PM 10=80-90%) and the coarser increasing in winter (PM 2.5/PM 10=60-70%). Meso- and synoptic scale processes affecting global PM levels in the Basque Country have been identified (mainly pollution episodes, African, Atlantic and EU transport). The results obtained allowed us to evaluate the impact of the different types of PM episodes on ambient PM levels and particle size fractions.

Biogeochemical provinces in the global ocean based on phytoplankton growth limitation

NASA Astrophysics Data System (ADS)

Hashioka, T.; Hirata, T.; Aita, M. N.; Chiba, S.

2016-02-01

The biogeochemical province is one of the useful concepts for the comprehensive understanding of regional differences of the marine ecosystem. Various biogeochemical provinces for lower-trophic level ecosystem have been proposed using a similarity-based classification of seasonal variations of chl-a concentration typified by Longhurst 1995 and 2006. Such categorizations well capture the regional differences of seasonality as "total phytoplankton". However, background biogeochemical mechanism to characterize the province boundary is not clear. Namely, the dominant phytoplankton group is different among regions and seasons, and their physiological characteristics are significantly different among groups. Recently some pieces of new biogeochemical information are available. One is an estimation of phytoplankton community structure from satellite observation, and it makes clear the key phytoplankton type in each region. Another is an estimation of limitation factors for phytoplankton growth (e.g., nutrients, temperature, light) in each region from modeling studies. In this study, we propose new biogeochemical provinces as a combination between the dominance of phytoplankton (i.e., diatoms, nano-, pico-phytoplankton or coexistence of two/three types) and their growth limitation factors (particularly we focused on nutrient limitation; N, P, Si or Fe). In this combination, we classified the global ocean into 23 biogeochemical provinces. The result suggests that even if the same type of phytoplankton dominates, the background mechanism could be different among regions. On the contrary, even if the regions geographically separate, the background mechanism could be similar among regions. This is important to understand that region/boundary does respond to environmental change. This biogeochemical province is useful for identification of key areas for future observation.

Estimates of N2O, NO and NH3 Emissions From Croplands in East, Southeast and South Asia

NASA Astrophysics Data System (ADS)

Yan, X.; Ohara, T.; Akimoto, H.

2002-12-01

Agricultural activities have greatly altered the global nitrogen cycle and produced nitrogenous gases of environmentally significance. More than half of the global chemical nitrogen fertilizer is used for crop production in East, Southeast and South Asia where rice the center of nutrition. Emissions of nitrous oxide (N2O), nitric oxide (NO) and ammonia (NH3) from croplands in this region were estimated by considering both background emission and emissions resulted from nitrogen added to croplands, including chemical nitrogen, animal manure used as fertilizer, biological fixed nitrogen and nitrogen in crop residue returned to field. Background emission fluxes of N2O and NO from croplands were estimated at 1.16 and 0.52 kg N ha-1yr-1, respectively. A fertilizer-induced N2O emission factor of 1.25% for upland was adopted from IPCC guidelines, and a factor of 0.25% was derived for paddy field from measurements. Total N2O emission from croplands in the region was estimated at 1.16 Tg N yr-1, with 41% contributed by background emission which was not considered in previous global estimates. However, the average fertilizer-induced N2O emission is only 0.93%, lower than the default IPCC value of 1.25% due to the low emission factor from paddy field. A fertilizer-induced NO emission factor of 0.66% for upland was derived from field measurements, and a factor of 0.13% was assumed for paddy field. Total NO emission was 572 Gg N yr-1 in the region, with 38% due to background emission. Average fertilizer-induce NO emission factor was 0.48%. Extrapolating this estimate to global scale will result in a global NO emission from cropland of 1.6 Tg N yr-1, smaller than other global estimates. Total NH3 emission was estimated at 11.8 Tg N yr-1. The use of urea and ammonium bicarbonate and the cultivation of rice lead to a high average NH3 loss rate of chemical fertilizer in the region. Emissions were distributed at 0.5° grid by using a global landuse database.

Laterality across languages: Results from a global dichotic listening study using a smartphone application

PubMed Central

Bless, Josef J.; Westerhausen, René; Torkildsen, Janne von Koss; Gudmundsen, Magne; Kompus, Kristiina; Hugdahl, Kenneth

2015-01-01

Left-hemispheric language dominance has been suggested by observations in patients with brain damages as early as the 19th century, and has since been confirmed by modern behavioural and brain imaging techniques. Nevertheless, most of these studies have been conducted in small samples with predominantly Anglo-American background, thus limiting generalization and possible differences between cultural and linguistic backgrounds may be obscured. To overcome this limitation, we conducted a global dichotic listening experiment using a smartphone application for remote data collection. The results from over 4,000 participants with more than 60 different language backgrounds showed that left-hemispheric language dominance is indeed a general phenomenon. However, the degree of lateralization appears to be modulated by linguistic background. These results suggest that more emphasis should be placed on cultural/linguistic specificities of psychological phenomena and on the need to collect more diverse samples. PMID:25588000

Laterality across languages: Results from a global dichotic listening study using a smartphone application.

PubMed

Bless, Josef J; Westerhausen, René; von Koss Torkildsen, Janne; Gudmundsen, Magne; Kompus, Kristiina; Hugdahl, Kenneth

2015-01-01

Left-hemispheric language dominance has been suggested by observations in patients with brain damages as early as the 19th century, and has since been confirmed by modern behavioural and brain imaging techniques. Nevertheless, most of these studies have been conducted in small samples with predominantly Anglo-American background, thus limiting generalization and possible differences between cultural and linguistic backgrounds may be obscured. To overcome this limitation, we conducted a global dichotic listening experiment using a smartphone application for remote data collection. The results from over 4,000 participants with more than 60 different language backgrounds showed that left-hemispheric language dominance is indeed a general phenomenon. However, the degree of lateralization appears to be modulated by linguistic background. These results suggest that more emphasis should be placed on cultural/linguistic specificities of psychological phenomena and on the need to collect more diverse samples.

Helium escape from the Earth's atmosphere - The charge exchange mechanism revisited

NASA Technical Reports Server (NTRS)

Lie-Svendsen, O.; Rees, M. H.; Stamnes, K.

1992-01-01

We have studied the escape of neutral helium from the terrestrial atmosphere through exothermic charge exchange reactions between He(+) ions and the major atmospheric constituents N2, O2 and O. Elastic collisions with the neutral background particles were treated quantitatively using a recently developed kinetic theory approach. An interhemispheric plasma transport model was employed to provide a global distribution of He(+) ions as a function of altitude, latitude and local solar time and for different levels of solar ionization. Combining these ion densities with neutral densities from an MSIS model and best estimates for the reaction rate coefficients of the charge exchange reactions, we computed the global distribution of the neutral He escape flux. The escape rates show large diurnal and latitudinal variations, while the global average does not vary by more than a factor of three over a solar cycle. We find that this escape mechanism is potentially important for the overall balance of helium in the Earth's atmosphere. However, more accurate values for the reaction rate coefficients of the charge exchange reactions are required to make a definitive assessment of its importance.

Effects of Global Cerebral Ischemia in the Pregnant Rat

PubMed Central

Spencer, Sarah J.; Galic, Michael A.; Tsutsui, Mio; Pittman, Quentin J.; Mouihate, Abdeslam

2012-01-01

Background and Purpose Stroke during pregnancy is an emerging concern. Although females undergo many physiological, endocrine, and neurological alterations during pregnancy, the consequences of such changes on outcome after stroke are unclear. It is predicted that increases in steroid hormones observed during pregnancy may confer protective effects against the neurological and pathological sequelae of stroke. Methods We therefore investigated behavioral and histological consequences of a global cerebral ischemia (2-vessel occlusion; 2VO), and how these outcomes correlated with pregnancy-related changes in hormones in Sprague-Dawley rats. Results After the 2VO, pregnant rats exhibited poorer memory in a contextual fear conditioning test of learning and memory than sham-treated controls, whereas nonpregnant rats did not. They also showed enhanced CA1 hippocampal neuronal injury. This susceptibility to damage is despite significant pregnancy-associated hypothermia and is probably not associated with alterations in 17β-estradiol or corticosterone levels. Conclusion These findings are the first to show enhanced neuronal damage in pregnant animals after global cerebral ischemia. They also suggest that the mechanism may be independent of changes in estrogen, corticosterone, and body temperature. PMID:18239170

Nonlinear climate sensitivity and its implications for future greenhouse warming.

PubMed

Friedrich, Tobias; Timmermann, Axel; Tigchelaar, Michelle; Elison Timm, Oliver; Ganopolski, Andrey

2016-11-01

Global mean surface temperatures are rising in response to anthropogenic greenhouse gas emissions. The magnitude of this warming at equilibrium for a given radiative forcing-referred to as specific equilibrium climate sensitivity ( S )-is still subject to uncertainties. We estimate global mean temperature variations and S using a 784,000-year-long field reconstruction of sea surface temperatures and a transient paleoclimate model simulation. Our results reveal that S is strongly dependent on the climate background state, with significantly larger values attained during warm phases. Using the Representative Concentration Pathway 8.5 for future greenhouse radiative forcing, we find that the range of paleo-based estimates of Earth's future warming by 2100 CE overlaps with the upper range of climate simulations conducted as part of the Coupled Model Intercomparison Project Phase 5 (CMIP5). Furthermore, we find that within the 21st century, global mean temperatures will very likely exceed maximum levels reconstructed for the last 784,000 years. On the basis of temperature data from eight glacial cycles, our results provide an independent validation of the magnitude of current CMIP5 warming projections.

Nonlinear climate sensitivity and its implications for future greenhouse warming

PubMed Central

Friedrich, Tobias; Timmermann, Axel; Tigchelaar, Michelle; Elison Timm, Oliver; Ganopolski, Andrey

2016-01-01

Global mean surface temperatures are rising in response to anthropogenic greenhouse gas emissions. The magnitude of this warming at equilibrium for a given radiative forcing—referred to as specific equilibrium climate sensitivity (S)—is still subject to uncertainties. We estimate global mean temperature variations and S using a 784,000-year-long field reconstruction of sea surface temperatures and a transient paleoclimate model simulation. Our results reveal that S is strongly dependent on the climate background state, with significantly larger values attained during warm phases. Using the Representative Concentration Pathway 8.5 for future greenhouse radiative forcing, we find that the range of paleo-based estimates of Earth’s future warming by 2100 CE overlaps with the upper range of climate simulations conducted as part of the Coupled Model Intercomparison Project Phase 5 (CMIP5). Furthermore, we find that within the 21st century, global mean temperatures will very likely exceed maximum levels reconstructed for the last 784,000 years. On the basis of temperature data from eight glacial cycles, our results provide an independent validation of the magnitude of current CMIP5 warming projections. PMID:28861462

Gender Differences in Stressors Related to Migration and Acculturation in Patients with Psychiatric Disorders and Turkish Migration Background.

PubMed

Müller, Matthias Johannes; Koch, Eckhardt

2017-06-01

Migration, acculturation, and psychiatric disorders may cause stress and adaptation processes differently in men and women, but empirical research is scarce. In a retrospective study n = 62 Turkish migrants and n = 62 native German inpatients with depressive or anxiety disorders, matched for age, gender, and diagnoses, were compared using a 10-item instrument for the assessment of migration- and acculturation related stressors (MIGSTR10). Gender differences in the prevalence of stressors and in the total sum of stressors were calculated and compared between migrants and indigenous patients. Results showed a higher global stress level in migrants and in women than in men with migration background. Regarding single stressors, the perceived loss of status was significantly more prevalent and more pronounced in men than in women (P < 0.05) whereas guilt feelings were more severe in women with Turkish migration background compared to men (P < 0.05). Gender differences of perceived stress should be taken into account in migration and acculturation research.

Background ozone in North China: trends, photochemical and transport impacts

NASA Astrophysics Data System (ADS)

Xu, X.; Lin, W.; Ge, B.

2011-12-01

Tropospheric ozone is one of the key greenhouse gases and plays an important role in atmospheric chemistry. Being a strong oxidant, ozone in the surface layer has significant impacts on human and vegetation health. Long-term measurements of surface ozone are highly needed for climate change assessment and environmental policy-making. Such measurements are scarce, particularly from the background regions. Since 2004, surface ozone and some related reactive gases have been observed at Shangdianzi (SDZ), a Global Atmosphere Watch (GAW) station in North China. Located at the north edge of the Northern China Plain (NCP), the SDZ station is an ideal site for capturing polluted air masses from the NCP sector (southwest) and clean air masses from the background sector (northeast). This facilitates the investigation of impacts of regional transport on surface ozone. In this study, we present long-term measurements of surface ozone made at SDZ, discuss the trends of surface ozone levels in different seasons. Results about the observation-based ozone production efficiency (OPE) for the site will be presented, along with impacts from horizontal and vertical air transport.

Background ozone in North China: trends, photochemical and transport impacts

NASA Astrophysics Data System (ADS)

Xu, X.; Lin, W.; Ge, B.

2012-04-01

Tropospheric ozone is one of the key greenhouse gases and plays an important role in atmospheric chemistry. Being a strong oxidant, ozone in the surface layer has significant impacts on human and vegetation health. Long-term measurements of surface ozone are highly needed for climate change assessment and environmental policy-making. Such measurements are scarce, particularly from the background regions. Since 2004, surface ozone and some related reactive gases have been observed at Shangdianzi (SDZ), a Global Atmosphere Watch (GAW) station in North China. Located at the north edge of the Northern China Plain (NCP), the SDZ station is an ideal site for capturing polluted air masses from the NCP sector (southwest) and clean air masses from the background sector (northeast). This facilitates the investigation of impacts of regional transport on surface ozone. In this study, we present long-term measurements of surface ozone made at SDZ, discuss the trends of surface ozone levels in different seasons. Results about the observation-based ozone production efficiency (OPE) for the site will be presented, along with impacts from horizontal and vertical air transport.

Some Major Issues of the International Future.

ERIC Educational Resources Information Center

Hopkins, Frank Snowden

Mankind's problems, which tend to be global in nature and extent, need global solutions. This paper lists and elaborates on a number of these global problems. No solutions are given. The first part of the paper presents background information on the following issues with which the world's governments will be dealing in the next quarter century:…

The Impact of Background Music on Adult Listeners: A Meta-Analysis

ERIC Educational Resources Information Center

Kampfe, Juliane; Sedlmeier, Peter; Renkewitz, Frank

2011-01-01

Background music has been found to have beneficial, detrimental, or no effect on a variety of behavioral and psychological outcome measures. This article reports a meta-analysis that attempts to summarize the impact of background music. A global analysis shows a null effect, but a detailed examination of the studies that allow the calculation of…

Dispersion of Fukushima radionuclides in the global atmosphere and the ocean.

PubMed

Povinec, P P; Gera, M; Holý, K; Hirose, K; Lujaniené, G; Nakano, M; Plastino, W; Sýkora, I; Bartok, J; Gažák, M

2013-11-01

Large quantities of radionuclides were released in March-April 2011 during the accident of the Fukushima Dai-ichi Nuclear Power Plant to the atmosphere and the ocean. Atmospheric and marine modeling has been carried out to predict the dispersion of radionuclides worldwide, to compare the predicted and measured radionuclide concentrations, and to assess the impact of the accident on the environment. Atmospheric Lagrangian dispersion modeling was used to simulate the dispersion of (137)Cs over America and Europe. Global ocean circulation model was applied to predict the dispersion of (137)Cs in the Pacific Ocean. The measured and simulated (137)Cs concentrations in atmospheric aerosols and in seawater are compared with global fallout and the Chernobyl accident, which represent the main sources of the pre-Fukushima radionuclide background in the environment. The radionuclide concentrations in the atmosphere have been negligible when compared with the Chernobyl levels. The maximum (137)Cs concentration in surface waters of the open Pacific Ocean will be around 20 Bq/m(3). The plume will reach the US coast 4-5 y after the accident, however, the levels will be below 3 Bq/m(3). All the North Pacific Ocean will be labeled with Fukushima (137)Cs 10 y after the accident with concentration bellow 1 Bq/m(3). Copyright © 2013 Elsevier Ltd. All rights reserved.

Prioritisation of food-borne parasites in Europe, 2016

PubMed Central

Bouwknegt, Martijn; Devleesschauwer, Brecht; Graham, Heather; Robertson, Lucy J; van der Giessen, Joke WB

2018-01-01

Background and aims Priority setting is a challenging task for public health professionals. To support health professionals with this and in following a recommendation from the Food and Agriculture Organization of the United Nations (FAO) and World Health Organization (WHO), 35 European parasitologists attended a workshop from 8–12 February 2016 to rank food-borne parasites (FBP) in terms of their importance for Europe and regions within Europe. Methods: Countries were divided into European regions according to those used by the European Society of Clinical Microbiology and Infectious Diseases. We used the same multicriteria decision analysis approach as the FAO/WHO, for comparison of results, and a modified version, for better regional representation. Twenty-five FBP were scored in subgroups, using predefined decision rules. Results: At the European level, Echinococcus multilocularis ranked first, followed by Toxoplasma gondii and Trichinella spiralis. At the regional level, E. multilocularis ranked highest in Northern and Eastern Europe, E. granulosus in South-Western and South-Eastern Europe, and T. gondii in Western Europe. Anisakidae, ranking 17th globally, appeared in each European region’s top 10. In contrast, Taenia solium, ranked highest globally but 10th for Europe. Conclusions: FBP of importance in Europe differ from those of importance globally, requiring targeted surveillance systems, intervention measures, and preparedness planning that differ across the world and across Europe. PMID:29510783

Genome-Wide Transcriptome Analyses of Silicon Metabolism in Phaeodactylum tricornutum Reveal the Multilevel Regulation of Silicic Acid Transporters

PubMed Central

Sapriel, Guillaume; Quinet, Michelle; Heijde, Marc; Jourdren, Laurent; Tanty, Véronique; Luo, Guangzuo; Le Crom, Stéphane; Lopez, Pascal Jean

2009-01-01

Background Diatoms are largely responsible for production of biogenic silica in the global ocean. However, in surface seawater, Si(OH)4 can be a major limiting factor for diatom productivity. Analyzing at the global scale the genes networks involved in Si transport and metabolism is critical in order to elucidate Si biomineralization, and to understand diatoms contribution to biogeochemical cycles. Methodology/Principal Findings Using whole genome expression analyses we evaluated the transcriptional response to Si availability for the model species Phaeodactylum tricornutum. Among the differentially regulated genes we found genes involved in glutamine-nitrogen pathways, encoding putative extracellular matrix components, or involved in iron regulation. Some of these compounds may be good candidates for intracellular intermediates involved in silicic acid storage and/or intracellular transport, which are very important processes that remain mysterious in diatoms. Expression analyses and localization studies gave the first picture of the spatial distribution of a silicic acid transporter in a diatom model species, and support the existence of transcriptional and post-transcriptional regulations. Conclusions/Significance Our global analyses revealed that about one fourth of the differentially expressed genes are organized in clusters, underlying a possible evolution of P. tricornutum genome, and perhaps other pennate diatoms, toward a better optimization of its response to variable environmental stimuli. High fitness and adaptation of diatoms to various Si levels in marine environments might arise in part by global regulations from gene (expression level) to genomic (organization in clusters, dosage compensation by gene duplication), and by post-transcriptional regulation and spatial distribution of SIT proteins. PMID:19829693

Computer-aided global breast MR image feature analysis for prediction of tumor response to chemotherapy: performance assessment

NASA Astrophysics Data System (ADS)

Aghaei, Faranak; Tan, Maxine; Hollingsworth, Alan B.; Zheng, Bin; Cheng, Samuel

2016-03-01

Dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI) has been used increasingly in breast cancer diagnosis and assessment of cancer treatment efficacy. In this study, we applied a computer-aided detection (CAD) scheme to automatically segment breast regions depicting on MR images and used the kinetic image features computed from the global breast MR images acquired before neoadjuvant chemotherapy to build a new quantitative model to predict response of the breast cancer patients to the chemotherapy. To assess performance and robustness of this new prediction model, an image dataset involving breast MR images acquired from 151 cancer patients before undergoing neoadjuvant chemotherapy was retrospectively assembled and used. Among them, 63 patients had "complete response" (CR) to chemotherapy in which the enhanced contrast levels inside the tumor volume (pre-treatment) was reduced to the level as the normal enhanced background parenchymal tissues (post-treatment), while 88 patients had "partially response" (PR) in which the high contrast enhancement remain in the tumor regions after treatment. We performed the studies to analyze the correlation among the 22 global kinetic image features and then select a set of 4 optimal features. Applying an artificial neural network trained with the fusion of these 4 kinetic image features, the prediction model yielded an area under ROC curve (AUC) of 0.83+/-0.04. This study demonstrated that by avoiding tumor segmentation, which is often difficult and unreliable, fusion of kinetic image features computed from global breast MR images without tumor segmentation can also generate a useful clinical marker in predicting efficacy of chemotherapy.

Exploring the MIS M2 glaciation occurring during a warm and high atmospheric CO2 Pliocene background climate

NASA Astrophysics Data System (ADS)

Tan, Ning; Ramstein, Gilles; Dumas, Christophe; Contoux, Camille; Ladant, Jean-Baptiste; Sepulchre, Pierre; Zhang, Zhongshi; De Schepper, Stijn

2017-08-01

Prior to the Northern Hemisphere glaciation around ∼2.7 Ma, a large global glaciation corresponding to a 20 to 60 m sea-level drop occurred during Marine Isotope Stage (MIS) M2 (3.312-3.264 Ma), interrupted the period of global warmth and high CO2 concentration (350-450 ppmv) of the mid Piacenzian. Unlike the late Quaternary glaciations, the M2 glaciation only lasted 50 kyrs and occurred under uncertain CO2 concentration (220-390 ppmv). The mechanisms causing the onset and termination of the M2 glaciation remain enigmatic, but a recent geological hypothesis suggests that the re-opening and closing of the shallow Central American Seaway (CAS) might have played a key role. In this article, thanks to a series of climate simulations carried out using a fully coupled Atmosphere Ocean General Circulation Model (GCM) and a dynamic ice sheet model, we show that re-opening of the shallow CAS helps precondition the low-latitude oceanic circulation and affects the related northward energy transport, but cannot alone explain the onset of the M2 glaciation. The presence of a shallow open CAS, together with favourable orbital parameters, 220 ppmv of CO2 concentration, and the related vegetation and ice sheet feedback, led to a global ice sheet build-up producing a global sea-level drop in the lowest range of proxy-derived estimates. More importantly, our results show that the simulated closure of the CAS has a negligible impact on the NH ice sheet melt and cannot explain the MIS M2 termination.

Seasonality of cholera from 1974 to 2005: a review of global patterns

PubMed Central

Emch, Michael; Feldacker, Caryl; Islam, M Sirajul; Ali, Mohammad

2008-01-01

Background The seasonality of cholera is described in various study areas throughout the world. However, no study examines how temporal cycles of the disease vary around the world or reviews its hypothesized causes. This paper reviews the literature on the seasonality of cholera and describes its temporal cycles by compiling and analyzing 32 years of global cholera data. This paper also provides a detailed literature review on regional patterns and environmental and climatic drivers of cholera patterns. Data, Methods, and Results Cholera data are compiled from 1974 to 2005 from the World Health Organization Weekly Epidemiological Reports, a database that includes all reported cholera cases in 140 countries. The data are analyzed to measure whether season, latitude, and their interaction are significantly associated with the country-level number of outbreaks in each of the 12 preceding months using separate negative binomial regression models for northern, southern, and combined hemispheres. Likelihood ratios tests are used to determine the model of best fit. The results suggest that cholera outbreaks demonstrate seasonal patterns in higher absolute latitudes, but closer to the equator, cholera outbreaks do not follow a clear seasonal pattern. Conclusion The findings suggest that environmental and climatic factors partially control the temporal variability of cholera. These results also indirectly contribute to the growing debate about the effects of climate change and global warming. As climate change threatens to increase global temperature, resulting rises in sea levels and temperatures may influence the temporal fluctuations of cholera, potentially increasing the frequency and duration of cholera outbreaks. PMID:18570659

Regional Air Pollutions in Three Different Regions of Asia From a Transcontinental Transport Perspective

NASA Astrophysics Data System (ADS)

Pochanart, P.; Kanaya, Y.; Komazaki, Y.; Liu, Y.; Akimoto, H.

2007-12-01

Asia is known as one of the regions with the fastest rate of growing in industrialization and urbanization. As a result, the rapid increases of large-scale air pollution in Asia emerge as a serious concern at both domestic and international levels. Apart from the problems of air quality degradation, emission control, environmental risk, and health effect in a domestic level, evidences from scientific studies indicate that by the long-range transport, Asian air pollution is becoming a global problem. Observations and model studies confirm that air pollution from Asia could be transported to North America or farther. In this work, we investigate the Asian air pollutions, in particular ozone and some other atmospheric components such as carbon monoxide and black carbon, from the ground- based observations in the three different regions, namely 1) background region of Siberia and central Asia, 2) highly anthropogenic region in eastern China, and 3) the rim region of the Asia-Pacific. In a transcontinental transport perspective, these regions are regarded as the inflow region, source region, and outflow region of Asia, respectively. From the results, it is found that the influences from large-scale emission in East Asia are observed clearly in the source region, and to the significant extent in the outflow region. For the inflow region of Asia, our data in Siberia and Kyrgyzstan indicate that air masses in this region are mostly intact from large-scale anthropogenic emission, and remain much of the global background atmospheric pollution characteristic. When the air masses are transported to source region, the air pollutants level increased sharply and frequent episodes of extremely high pollutions have been observed. Our results show good correlation between the residence time of air masses over the source region in eastern China and the observed levels of air pollutants verifying the strong enhancements by anthropogenic emissions from industrialization and urbanization. In the outflow region, air pollutants characteristics depend largely on the air mass climatology. In most cases, increases of air pollutants level are observed with the transport events directly from the source region.

WorldWideScience.org: the global science gateway.

PubMed

Fitzpatrick, Roberta Bronson

2009-10-01

WorldWideScience.org is a Web-based global gateway connecting users to both national and international scientific databases and portals. This column will provide background information on the resource as well as introduce basic searching practices for users.

Analyzing Personal Happiness from Global Survey and Weather Data: A Geospatial Approach

PubMed Central

Peng, Yi-Fan; Tang, Jia-Hong; Fu, Yang-chih; Fan, I-chun; Hor, Maw-Kae; Chan, Ta-Chien

2016-01-01

Past studies have shown that personal subjective happiness is associated with various macro- and micro-level background factors, including environmental conditions, such as weather and the economic situation, and personal health behaviors, such as smoking and exercise. We contribute to this literature of happiness studies by using a geospatial approach to examine both macro and micro links to personal happiness. Our geospatial approach incorporates two major global datasets: representative national survey data from the International Social Survey Program (ISSP) and corresponding world weather data from the National Oceanic and Atmospheric Administration (NOAA). After processing and filtering 55,081 records of ISSP 2011 survey data from 32 countries, we extracted 5,420 records from China and 25,441 records from 28 other countries. Sensitivity analyses of different intervals for average weather variables showed that macro-level conditions, including temperature, wind speed, elevation, and GDP, are positively correlated with happiness. To distinguish the effects of weather conditions on happiness in different seasons, we also adopted climate zone and seasonal variables. The micro-level analysis indicated that better health status and eating more vegetables or fruits are highly associated with happiness. Never engaging in physical activity appears to make people less happy. The findings suggest that weather conditions, economic situations, and personal health behaviors are all correlated with levels of happiness. PMID:27078263

Possible impact of global warming and ocean acidification on underwater sound in northern oceans: another perfect storm

NASA Astrophysics Data System (ADS)

Browning, David

2011-04-01

The greatest ocean pH change, which will result in lower low frequency sound attenuation, is predicted for higher latitudes. Here shallow sound channel axies exist, allowing the impact on sound to be seen sooner and also more extensively since the principal propagation paths will be near the surface. However, at the same time, higher wind speeds and greater ice breakup,as well as increased ship traffic, could result in higher noise levels. Marine mammals in this environment may have, on one hand, improving communication conditions but also the possibility of increased background noise.

Aberrant Global and Regional Topological Organization of the Fractional Anisotropy-weighted Brain Structural Networks in Major Depressive Disorder

PubMed Central

Chen, Jian-Huai; Yao, Zhi-Jian; Qin, Jiao-Long; Yan, Rui; Hua, Ling-Ling; Lu, Qing

2016-01-01

Background: Most previous neuroimaging studies have focused on the structural and functional abnormalities of local brain regions in major depressive disorder (MDD). Moreover, the exactly topological organization of networks underlying MDD remains unclear. This study examined the aberrant global and regional topological patterns of the brain white matter networks in MDD patients. Methods: The diffusion tensor imaging data were obtained from 27 patients with MDD and 40 healthy controls. The brain fractional anisotropy-weighted structural networks were constructed, and the global network and regional nodal metrics of the networks were explored by the complex network theory. Results: Compared with the healthy controls, the brain structural network of MDD patients showed an intact small-world topology, but significantly abnormal global network topological organization and regional nodal characteristic of the network in MDD were found. Our findings also indicated that the brain structural networks in MDD patients become a less strongly integrated network with a reduced central role of some key brain regions. Conclusions: All these resulted in a less optimal topological organization of networks underlying MDD patients, including an impaired capability of local information processing, reduced centrality of some brain regions and limited capacity to integrate information across different regions. Thus, these global network and regional node-level aberrations might contribute to understanding the pathogenesis of MDD from the view of the brain network. PMID:26960371

Explaining ecological clusters of maternal depression in South Western Sydney

PubMed Central

2014-01-01

Background The aim of the qualitative study reported here was to: 1) explain the observed clustering of postnatal depressive symptoms in South Western Sydney; and 2) identify group-level mechanisms that would add to our understanding of the social determinants of maternal depression. Methods Critical realism provided the methodological underpinning for the study. The setting was four local government areas in South Western Sydney, Australia. Child and Family practitioners and mothers in naturally occurring mothers groups were interviewed. Results Using an open coding approach to maximise emergence of patterns and relationships we have identified seven theoretical concepts that might explain the observed spatial clustering of maternal depression. The theoretical concepts identified were: Community-level social networks; Social Capital and Social Cohesion; "Depressed community"; Access to services at the group level; Ethnic segregation and diversity; Supportive social policy; and Big business. Conclusions We postulate that these regional structural, economic, social and cultural mechanisms partially explain the pattern of maternal depression observed in families and communities within South Western Sydney. We further observe that powerful global economic and political forces are having an impact on the local situation. The challenge for policy and practice is to support mothers and their families within this adverse regional and global-economic context. PMID:24460690

Tentative reference values for environmental pollutants in blood or urine from the children of Kinshasa.

PubMed

Tuakuila, J; Kabamba, M; Mata, H; Mbuyi, F

2015-11-01

The DRC, as most of African nations, does not have a national biomonitoring programme and there is a lack of information on background levels of environmental pollutants in the general DRC population, particularly in children. The focus of the data presented in this report aims to establish the background levels of a range of environmental pollutants in urine or blood from the children population of Kinshasa. Based on the representative data collection of the Kinshasa population, the survey selected 125 children aged 1-14years and living in Kinshasa (6years on average, 56% of girls, 100% of non-smokers, without amalgam fillings and consumers of fish 3 times per week). Biomarkers of a range of metals (As, Cd, Hg and Pb), pyrene (PAH) and benzene were analyzed in the blood or urine samples. Globally, the results indicate that the exposure levels of children living in Kinshasa are 10 times higher than those published by the American, Canadian and German children surveys. This study provides the first Reference Values of environmental pollutants [As, Cd, Hg, Pb, pyrene (PAH) and benzene] in the Kinshasa children population and reveals elevated levels of all biomarkers studied. The data set of this study may allow environmental and health authorities of DRC to undertake a national biomonitoring programme, especially with four insights for the protection of human heath. Copyright © 2015 Elsevier Ltd. All rights reserved.

A case study of global health at the university: implications for research and action

PubMed Central

Pinto, Andrew D.; Cole, Donald C.; ter Kuile, Aleida; Forman, Lisa; Rouleau, Katherine; Philpott, Jane; Pakes, Barry; Jackson, Suzanne; Muntaner, Carles

2014-01-01

Background Global health is increasingly a major focus of institutions in high-income countries. However, little work has been done to date to study the inner workings of global health at the university level. Academics may have competing objectives, with few mechanisms to coordinate efforts and pool resources. Objective To conduct a case study of global health at Canada's largest health sciences university and to examine how its internal organization influences research and action. Design We drew on existing inventories, annual reports, and websites to create an institutional map, identifying centers and departments using the terms ‘global health’ or ‘international health’ to describe their activities. We compiled a list of academics who self-identified as working in global or international health. We purposively sampled persons in leadership positions as key informants. One investigator carried out confidential, semi-structured interviews with 20 key informants. Interview notes were returned to participants for verification and then analyzed thematically by pairs of coders. Synthesis was conducted jointly. Results More than 100 academics were identified as working in global health, situated in numerous institutions, centers, and departments. Global health academics interviewed shared a common sense of what global health means and the values that underpin such work. Most academics interviewed expressed frustration at the existing fragmentation and the lack of strategic direction, financial support, and recognition from the university. This hampered collaborative work and projects to tackle global health problems. Conclusions The University of Toronto is not exceptional in facing such challenges, and our findings align with existing literature that describes factors that inhibit collaboration in global health work at universities. Global health academics based at universities may work in institutional siloes and this limits both internal and external collaboration. A number of solutions to address these challenges are proposed. PMID:25172428

Impacts of the large increase in international ship traffic 2000-2007 on tropospheric ozone and methane.

PubMed

Dalsøren, Stig B; Eide, Magnus S; Myhre, Gunnar; Endresen, Oyvind; Isaksen, Ivar S A; Fuglestvedt, Jan S

2010-04-01

The increase in civil world fleet ship emissions during the period 2000-2007 and the effects on key tropospheric oxidants are quantified using a global Chemical Transport Model (CTM). We estimate a substantial increase of 33% in global ship emissions over this period. The impact of ship emissions on tropospheric oxidants is mainly caused by the relatively large fraction of NOx in ship exhaust. Typical increases in yearly average surface ozone concentrations in the most impacted areas are 0.5-2.5 ppbv. The global annual mean radiative forcing due to ozone increases in the troposphere is 10 mWm(-2) over the period 2000-2007. We find global average tropospheric OH increase of 1.03% over the same period. As a result of this the global average tropospheric methane concentration is reduced by approximately 2.2% over a period corresponding to the turnover time. The resulting methane radiative forcing is -14 mWm(-2) with an additional contribution of -6 mWm(-2) from methane induced reduction in ozone. The net forcing of the ozone and methane changes due to ship emissions changes between 2000 and 2007 is -10 mWm(-2). This is significant compared to the net forcing of these components in 2000. Our findings support earlier observational studies indicating that ship traffic may be a major contributor to recent enhancement of background ozone at some coastal stations. Furthermore, by reducing global mean tropospheric methane by 40 ppbv over its turnover time it is likely to contribute to the recent observed leveling off in global mean methane concentration.

Contextual cueing by global features

PubMed Central

Kunar, Melina A.; Flusberg, Stephen J.; Wolfe, Jeremy M.

2008-01-01

In visual search tasks, attention can be guided to a target item, appearing amidst distractors, on the basis of simple features (e.g. find the red letter among green). Chun and Jiang’s (1998) “contextual cueing” effect shows that RTs are also speeded if the spatial configuration of items in a scene is repeated over time. In these studies we ask if global properties of the scene can speed search (e.g. if the display is mostly red, then the target is at location X). In Experiment 1a, the overall background color of the display predicted the target location. Here the predictive color could appear 0, 400 or 800 msec in advance of the search array. Mean RTs are faster in predictive than in non-predictive conditions. However, there is little improvement in search slopes. The global color cue did not improve search efficiency. Experiments 1b-1f replicate this effect using different predictive properties (e.g. background orientation/texture, stimuli color etc.). The results show a strong RT effect of predictive background but (at best) only a weak improvement in search efficiency. A strong improvement in efficiency was found, however, when the informative background was presented 1500 msec prior to the onset of the search stimuli and when observers were given explicit instructions to use the cue (Experiment 2). PMID:17355043

Image segregation in strabismic amblyopia.

PubMed

Levi, Dennis M

2007-06-01

Humans with naturally occurring amblyopia show deficits thought to involve mechanisms downstream of V1. These include excessive crowding, abnormal global image processing, spatial sampling and symmetry detection and undercounting. Several recent studies suggest that humans with naturally occurring amblyopia show deficits in global image segregation. The current experiments were designed to study figure-ground segregation in amblyopic observers with documented deficits in crowding, symmetry detection, spatial sampling and counting, using similar stimuli. Observers had to discriminate the orientation of a figure (an "E"-like pattern made up of 17 horizontal Gabor patches), embedded in a 7x7 array of Gabor patches. When the 32 "background" patches are vertical, the "E" pops-out, due to segregation by orientation and performance is perfect; however, if the background patches are all, or mostly horizontal, the "E" is camouflaged, and performance is random. Using a method of constant stimuli, we varied the number of "background" patches that were vertical and measured the probability of correct discrimination of the global orientation of the E (up/down/left/right). Surprisingly, amblyopes who showed strong crowding and deficits in symmetry detection and counting, perform normally or very nearly so in this segregation task. I therefore conclude that these deficits are not a consequence of abnormal segregation of figure from background.

Forest, Trees, Dynamics: Results from a Novel Wisconsin Card Sorting Test Variant Protocol for Studying Global-Local Attention and Complex Cognitive Processes

PubMed Central

Cowley, Benjamin; Lukander, Kristian

2016-01-01

Background: Recognition of objects and their context relies heavily on the integrated functioning of global and local visual processing. In a realistic setting such as work, this processing becomes a sustained activity, implying a consequent interaction with executive functions. Motivation: There have been many studies of either global-local attention or executive functions; however it is relatively novel to combine these processes to study a more ecological form of attention. We aim to explore the phenomenon of global-local processing during a task requiring sustained attention and working memory. Methods: We develop and test a novel protocol for global-local dissociation, with task structure including phases of divided (“rule search”) and selective (“rule found”) attention, based on the Wisconsin Card Sorting Task (WCST). We test it in a laboratory study with 25 participants, and report on behavior measures (physiological data was also gathered, but not reported here). We develop novel stimuli with more naturalistic levels of information and noise, based primarily on face photographs, with consequently more ecological validity. Results: We report behavioral results indicating that sustained difficulty when participants test their hypotheses impacts matching-task performance, and diminishes the global precedence effect. Results also show a dissociation between subjectively experienced difficulty and objective dimension of performance, and establish the internal validity of the protocol. Contribution: We contribute an advance in the state of the art for testing global-local attention processes in concert with complex cognition. With three results we establish a connection between global-local dissociation and aspects of complex cognition. Our protocol also improves ecological validity and opens options for testing additional interactions in future work. PMID:26941689

Research Investments in Global Health: A Systematic Analysis of UK Infectious Disease Research Funding and Global Health Metrics, 1997–2013

PubMed Central

Head, Michael G.; Fitchett, Joseph R.; Nageshwaran, Vaitehi; Kumari, Nina; Hayward, Andrew; Atun, Rifat

2015-01-01

Background Infectious diseases account for a significant global burden of disease and substantial investment in research and development. This paper presents a systematic assessment of research investments awarded to UK institutions and global health metrics assessing disease burden. Methods We systematically sourced research funding data awarded from public and philanthropic organisations between 1997 and 2013. We screened awards for relevance to infection and categorised data by type of science, disease area and specific pathogen. Investments were compared with mortality, disability-adjusted life years (DALYs) and years lived with disability (YLD) across three time points. Findings Between 1997–2013, there were 7398 awards with a total investment of £3.7 billion. An increase in research funding across 2011–2013 was observed for most disease areas, with notable exceptions being sexually transmitted infections and sepsis research where funding decreased. Most funding remains for pre-clinical research (£2.2 billion, 59.4%). Relative to global mortality, DALYs and YLDs, acute hepatitis C, leishmaniasis and African trypanosomiasis received comparatively high levels of funding. Pneumonia, shigellosis, pertussis, cholera and syphilis were poorly funded across all health metrics. Tuberculosis (TB) consistently attracts relatively less funding than HIV and malaria. Interpretation Most infections have received increases in research investment, alongside decreases in global burden of disease in 2013. The UK demonstrates research strengths in some neglected tropical diseases such as African trypanosomiasis and leishmaniasis, but syphilis, cholera, shigellosis and pneumonia remain poorly funded relative to their global burden. Acute hepatitis C appears well funded but the figures do not adequately take into account projected future chronic burdens for this condition. These findings can help to inform global policymakers on resource allocation for research investment. PMID:26870829

Land Boundary Conditions for the Goddard Earth Observing System Model Version 5 (GEOS-5) Climate Modeling System: Recent Updates and Data File Descriptions

NASA Technical Reports Server (NTRS)

Mahanama, Sarith P.; Koster, Randal D.; Walker, Gregory K.; Takacs, Lawrence L.; Reichle, Rolf H.; De Lannoy, Gabrielle; Liu, Qing; Zhao, Bin; Suarez, Max J.

2015-01-01

The Earths land surface boundary conditions in the Goddard Earth Observing System version 5 (GEOS-5) modeling system were updated using recent high spatial and temporal resolution global data products. The updates include: (i) construction of a global 10-arcsec land-ocean lakes-ice mask; (ii) incorporation of a 10-arcsec Globcover 2009 land cover dataset; (iii) implementation of Level 12 Pfafstetter hydrologic catchments; (iv) use of hybridized SRTM global topography data; (v) construction of the HWSDv1.21-STATSGO2 merged global 30 arc second soil mineral and carbon data in conjunction with a highly-refined soil classification system; (vi) production of diffuse visible and near-infrared 8-day MODIS albedo climatologies at 30-arcsec from the period 2001-2011; and (vii) production of the GEOLAND2 and MODIS merged 8-day LAI climatology at 30-arcsec for GEOS-5. The global data sets were preprocessed and used to construct global raster data files for the software (mkCatchParam) that computes parameters on catchment-tiles for various atmospheric grids. The updates also include a few bug fixes in mkCatchParam, as well as changes (improvements in algorithms, etc.) to mkCatchParam that allow it to produce tile-space parameters efficiently for high resolution AGCM grids. The update process also includes the construction of data files describing the vegetation type fractions, soil background albedo, nitrogen deposition and mean annual 2m air temperature to be used with the future Catchment CN model and the global stream channel network to be used with the future global runoff routing model. This report provides detailed descriptions of the data production process and data file format of each updated data set.

Are national policies on global health in fact national policies on global health governance? A comparison of policy designs from Norway and Switzerland

PubMed Central

Clavier, Carole; Potvin, Louise

2017-01-01

Background Since the signing of the Oslo Ministerial Declaration in 2007, the idea that foreign policy formulation should include health considerations has gained traction on the United Nations agenda as evidenced by annual General Assembly resolutions on global health and foreign policy. The adoption of national policies on global health (NPGH) is one way that some member states integrate health and foreign policymaking. This paper explores what these policies intend to do and how countries plan to do it. Methods Using a most similar systems design, we carried out a comparative study of two policy documents formally adopted in 2012. We conducted a directed qualitative content analysis of the Norwegian White Paper on Global health in foreign and development policy and the Swiss Health Foreign Policy using Schneider and Ingram's policy design framework. After replicating analysis methods for each document, we analysed them side by side to explore the commonalities and differences across elements of NPGH design. Results Analyses indicate that NPGH expect to influence change outside their borders. Targeting the international level, they aim to affect policy venues, multilateral partnerships and international institutions. Instruments for supporting desired changes are primarily those of health diplomacy, proposed as a tool for negotiating interests and objectives for global health between multiple sectors, used internally in Switzerland and externally in Norway. Conclusion Findings suggest that NPGH designs contribute to constructing the global health governance system by identifying it as a policy target, and policy instruments may elude the health sector actors unless implementation rules explicitly include them. Research should explore how future NPGH designs may construct different kinds of targets as politicised groups of actors on which national governments seek to exercise influence for global health decision-making. PMID:28589007

The impact of different background errors in the assimilation of satellite radiances and in-situ observational data using WRFDA for three rainfall events over Iran

NASA Astrophysics Data System (ADS)

Zakeri, Zeinab; Azadi, Majid; Ghader, Sarmad

2018-01-01

Satellite radiances and in-situ observations are assimilated through Weather Research and Forecasting Data Assimilation (WRFDA) system into Advanced Research WRF (ARW) model over Iran and its neighboring area. Domain specific background error based on x and y components of wind speed (UV) control variables is calculated for WRFDA system and some sensitivity experiments are carried out to compare the impact of global background error and the domain specific background errors, both on the precipitation and 2-m temperature forecasts over Iran. Three precipitation events that occurred over the country during January, September and October 2014 are simulated in three different experiments and the results for precipitation and 2-m temperature are verified against the verifying surface observations. Results show that using domain specific background error improves 2-m temperature and 24-h accumulated precipitation forecasts consistently, while global background error may even degrade the forecasts compared to the experiments without data assimilation. The improvement in 2-m temperature is more evident during the first forecast hours and decreases significantly as the forecast length increases.

Limitations to Thermoregulation and Acclimatization Challenge Human Adaptation to Global Warming.

PubMed

Hanna, Elizabeth G; Tait, Peter W

2015-07-15

Human thermoregulation and acclimatization are core components of the human coping mechanism for withstanding variations in environmental heat exposure. Amidst growing recognition that curtailing global warming to less than two degrees is becoming increasing improbable, human survival will require increasing reliance on these mechanisms. The projected several fold increase in extreme heat events suggests we need to recalibrate health protection policies and ratchet up adaptation efforts. Climate researchers, epidemiologists, and policy makers engaged in climate change adaptation and health protection are not commonly drawn from heat physiology backgrounds. Injecting a scholarly consideration of physiological limitations to human heat tolerance into the adaptation and policy literature allows for a broader understanding of heat health risks to support effective human adaptation and adaptation planning. This paper details the physiological and external environmental factors that determine human thermoregulation and acclimatization. We present a model to illustrate the interrelationship between elements that modulate the physiological process of thermoregulation. Limitations inherent in these processes, and the constraints imposed by differing exposure levels, and thermal comfort seeking on achieving acclimatization, are then described. Combined, these limitations will restrict the likely contribution that acclimatization can play in future human adaptation to global warming. We postulate that behavioral and technological adaptations will need to become the dominant means for human individual and societal adaptations as global warming progresses.

Reefs happen

USGS Publications Warehouse

Kinzie, R. A.; Buddemeier, R.W.

1996-01-01

Corals and coral reefs confront us with a variety of paradoxes in terms of their responses to global change. The species appear evolutionarily long-lived and stable, and combinations of organisms recur and persist at levels ranging from endosymbiosis to palaeocommunity structure. The fact that these organisms and communities occupy a seemingly precarious environment near the common interface of land, sea, and air suggests that they possess powerful adaptive and acclimative mechanisms, and the special characteristics associated with their range of reproductive options, their modular (colonial) form, and their symbiotic associations provide multiple pathways for adaptation. At the same time, they are widely considered to be vulnerable to anthropogenic stresses, and to show signs of deterioration on a global scale. Interest in corals is further enhanced by their unique position with regard to the carbon cycle, with inorganic and organic carbon metabolisms that are of comparable magnitudes. The durable limestone structures they create modify the shallow-water environment, and their mineral skeletons preserve in their isotopic, chemical, and structural characteristics records of past environmental conditions. Whether as survivors, recorders, or victims, their relationship to global change is fascinating and instructive. This paper provides a general background and context for the specific papers that make up this topical issue of Global Change Biology. ?? 1996 Blackwell Science Ltd.

VNIR hyperspectral background characterization methods in adverse weather conditions

NASA Astrophysics Data System (ADS)

Romano, João M.; Rosario, Dalton; Roth, Luz

2009-05-01

Hyperspectral technology is currently being used by the military to detect regions of interest where potential targets may be located. Weather variability, however, may affect the ability for an algorithm to discriminate possible targets from background clutter. Nonetheless, different background characterization approaches may facilitate the ability for an algorithm to discriminate potential targets over a variety of weather conditions. In a previous paper, we introduced a new autonomous target size invariant background characterization process, the Autonomous Background Characterization (ABC) or also known as the Parallel Random Sampling (PRS) method, features a random sampling stage, a parallel process to mitigate the inclusion by chance of target samples into clutter background classes during random sampling; and a fusion of results at the end. In this paper, we will demonstrate how different background characterization approaches are able to improve performance of algorithms over a variety of challenging weather conditions. By using the Mahalanobis distance as the standard algorithm for this study, we compare the performance of different characterization methods such as: the global information, 2 stage global information, and our proposed method, ABC, using data that was collected under a variety of adverse weather conditions. For this study, we used ARDEC's Hyperspectral VNIR Adverse Weather data collection comprised of heavy, light, and transitional fog, light and heavy rain, and low light conditions.

A study on the birth and globalization of sports originated from each continent.

PubMed

Lee, Byung Jin; Kim, Tae Young

2016-02-01

The purpose of this research is to see how continent specific sports rose to its modern-day status through globalization. This research focuses on the historical background of how England's football, America's national pastime, baseball, Japan's Judo, and Korea's Taekwondo developed into sports in addition to the reasoning behind its globalization. Promoted by England and the rest of the European continent, Soccer is considered to be one of the world's most popular sports and has served its function as a form of cultural imperialism. It has also advanced alongside commerce, missionary work and other types of cultural clashes. In America, baseball was used to integrate its multicultural society and developed so that the team captain leads the rest of his team. The sports of Oriental countries were reborn through modernization that was influenced by the modern rationality, education etc. of its Western counterparts. Judo and Taekwondo were introduced globally through the Olympic Games. As mentioned above the birth of sporting events has a close connection to a nation's cultural background and globalization has taken different forms depending on which continent it originated from.

Examining the Role of Structural Diversity in Intercultural Competence

ERIC Educational Resources Information Center

Peifer, Janelle S.; Chambers, Karen L.; Lee, Elaine Meyer

2017-01-01

Higher Education Institutions (HEIs) across the United States have identified intercultural competence as a priority for students in the modern, globalized economy. Increasingly, institutions utilize an intersectional approach to understand how individuals from different backgrounds engage with global learning and international educational…

What Can Teacher Education Do?

ERIC Educational Resources Information Center

Sleeter, Christine

2008-01-01

Teachers bring to their work assumptions that shape how they think about globalization. To prepare children to analyze globalization perceptively, teachers must stretch their assumptions and knowledge; teacher education can help. First, if teacher candidates have not already had substantive interaction with people whose backgrounds and…

Association between background parenchymal enhancement of breast MRI and BIRADS rating change in the subsequent screening

NASA Astrophysics Data System (ADS)

Aghaei, Faranak; Mirniaharikandehei, Seyedehnafiseh; Hollingsworth, Alan B.; Stoug, Rebecca G.; Pearce, Melanie; Liu, Hong; Zheng, Bin

2018-03-01

Although breast magnetic resonance imaging (MRI) has been used as a breast cancer screening modality for high-risk women, its cancer detection yield remains low (i.e., <= 3%). Thus, increasing breast MRI screening efficacy and cancer detection yield is an important clinical issue in breast cancer screening. In this study, we investigated association between the background parenchymal enhancement (BPE) of breast MRI and the change of diagnostic (BIRADS) status in the next subsequent breast MRI screening. A dataset with 65 breast MRI screening cases was retrospectively assembled. All cases were rated BIRADS-2 (benign findings). In the subsequent screening, 4 cases were malignant (BIRADS-6), 48 remained BIRADS-2 and 13 were downgraded to negative (BIRADS-1). A computer-aided detection scheme was applied to process images of the first set of breast MRI screening. Total of 33 features were computed including texture feature and global BPE features. Texture features were computed from either a gray-level co-occurrence matrix or a gray level run length matrix. Ten global BPE features were also initially computed from two breast regions and bilateral difference between the left and right breasts. Box-plot based analysis shows positive association between texture features and BIRADS rating levels in the second screening. Furthermore, a logistic regression model was built using optimal features selected by a CFS based feature selection method. Using a leave-one-case-out based cross-validation method, classification yielded an overall 75% accuracy in predicting the improvement (or downgrade) of diagnostic status (to BIRAD-1) in the subsequent breast MRI screening. This study demonstrated potential of developing a new quantitative imaging marker to predict diagnostic status change in the short-term, which may help eliminate a high fraction of unnecessary repeated breast MRI screenings and increase the cancer detection yield.

Quality evaluation of extracted ion chromatograms and chromatographic peaks in liquid chromatography/mass spectrometry-based metabolomics data.

PubMed

Zhang, Wenchao; Zhao, Patrick X

2014-01-01

Extracted ion chromatogram (EIC) extraction and chromatographic peak detection are two important processing procedures in liquid chromatography/mass spectrometry (LC/MS)-based metabolomics data analysis. Most commonly, the LC/MS technique employs electrospray ionization as the ionization method. The EICs from LC/MS data are often noisy and contain high background signals. Furthermore, the chromatographic peak quality varies with respect to its location in the chromatogram and most peaks have zigzag shapes. Therefore, there is a critical need to develop effective metrics for quality evaluation of EICs and chromatographic peaks in LC/MS based metabolomics data analysis. We investigated a comprehensive set of potential quality evaluation metrics for extracted EICs and detected chromatographic peaks. Specifically, for EIC quality evaluation, we analyzed the mass chromatographic quality index (MCQ index) and propose a novel quality evaluation metric, the EIC-related global zigzag index, which is based on an EIC's first order derivatives. For chromatographic peak quality evaluation, we analyzed and compared six metrics: sharpness, Gaussian similarity, signal-to-noise ratio, peak significance level, triangle peak area similarity ratio and the local peak-related local zigzag index. Although the MCQ index is suited for selecting and aligning analyte components, it cannot fairly evaluate EICs with high background signals or those containing only a single peak. Our proposed EIC related global zigzag index is robust enough to evaluate EIC qualities in both scenarios. Of the six peak quality evaluation metrics, the sharpness, peak significance level, and zigzag index outperform the others due to the zigzag nature of LC/MS chromatographic peaks. Furthermore, using several peak quality metrics in combination is more efficient than individual metrics in peak quality evaluation.

The global limits and population at risk of soil-transmitted helminth infections in 2010

PubMed Central

2012-01-01

Background Understanding the global limits of transmission of soil-transmitted helminth (STH) species is essential for quantifying the population at-risk and the burden of disease. This paper aims to define these limits on the basis of environmental and socioeconomic factors, and additionally seeks to investigate the effects of urbanisation and economic development on STH transmission, and estimate numbers at-risk of infection with Ascaris lumbricoides, Trichuris trichiura and hookworm in 2010. Methods A total of 4,840 geo-referenced estimates of infection prevalence were abstracted from the Global Atlas of Helminth Infection and related to a range of environmental factors to delineate the biological limits of transmission. The relationship between STH transmission and urbanisation and economic development was investigated using high resolution population surfaces and country-level socioeconomic indicators, respectively. Based on the identified limits, the global population at risk of STH transmission in 2010 was estimated. Results High and low land surface temperature and extremely arid environments were found to limit STH transmission, with differential limits identified for each species. There was evidence that the prevalence of A. lumbricoides and of T. trichiura infection was statistically greater in peri-urban areas compared to urban and rural areas, whilst the prevalence of hookworm was highest in rural areas. At national levels, no clear socioeconomic correlates of transmission were identified, with the exception that little or no infection was observed for countries with a per capita gross domestic product greater than US$ 20,000. Globally in 2010, an estimated 5.3 billion people, including 1.0 billion school-aged children, lived in areas stable for transmission of at least one STH species, with 69% of these individuals living in Asia. A further 143 million (31.1 million school-aged children) lived in areas of unstable transmission for at least one STH species. Conclusions These limits provide the most contemporary, plausible representation of the extent of STH risk globally, and provide an essential basis for estimating the global disease burden due to STH infection. PMID:22537799

Global Assessment of Extinction Risk to Populations of Sockeye Salmon Oncorhynchus nerka

PubMed Central

Rand, Peter S.; Goslin, Matthew; Gross, Mart R.; Irvine, James R.; Augerot, Xanthippe; McHugh, Peter A.; Bugaev, Victor F.

2012-01-01

Background Concern about the decline of wild salmon has attracted the attention of the International Union for the Conservation of Nature (IUCN). The IUCN applies quantitative criteria to assess risk of extinction and publishes its results on the Red List of Threatened Species. However, the focus is on the species level and thus may fail to show the risk to populations. The IUCN has adapted their criteria to apply to populations but there exist few examples of this type of assessment. We assessed the status of sockeye salmon Oncorhynchus nerka as a model for application of the IUCN population-level assessments and to provide the first global assessment of the status of an anadromous Pacific salmon. Methods/Principal Findings We found from demographic data that the sockeye salmon species is not presently at risk of extinction. We identified 98 independent populations with varying levels of risk within the species' range. Of these, 5 (5%) are already extinct. We analyzed the risk for 62 out of 93 extant populations (67%) and found that 17 of these (27%) are at risk of extinction. The greatest number and concentration of extinct and threatened populations is in the southern part of the North American range, primarily due to overfishing, freshwater habitat loss, dams, hatcheries, and changing ocean conditions. Conclusions/Significance Although sockeye salmon are not at risk at the species-level, about one-third of the populations that we analyzed are at risk or already extinct. Without an understanding of risk to biodiversity at the level of populations, the biodiversity loss in salmon would be greatly underrepresented on the Red List. We urge government, conservation organizations, scientists and the public to recognize this limitation of the Red List. We also urge recognition that about one-third of sockeye salmon global population diversity is at risk of extinction or already extinct. PMID:22511930

Developing global health technology standards: what can other industries teach us?

PubMed Central

2013-01-01

Background There is a lack of effective and affordable technologies to address health needs in the developing world. One way to address problems of innovation and affordability is to design global health technologies to follow agreed-upon standards. This Debate article argues that we can better develop standards for global health technologies if we learn lessons from other industries. Discussion The article’s Background section begins by explaining why standards are needed in global health. For example, if global health technologies can be modularized into independent interfacing parts, these parts can then interact via well-defined standards in a “plug and play” fashion. This can avoid development of mutually incompatible solutions by different organizations, speed the pace of innovation, unlock health systems from single providers and approaches, and lower barriers to entry. The Background then gives a brief primer on standards and discusses incentives for health standards. The article’s Discussion section begins with brief relevant cases of standards development from other industries, including electricity, container shipping, CD standards, Universal Serial Bus (USB), and the Internet. It then explores lessons from these and other industries that suggest how to develop standards for global health technologies. The remainder of the Discussion considers intellectual property and regulatory issues and standards-based global health business models, and ends with a checklist of considerations for health standards development leaders. (The associated Additional file discusses observations from standards development for cell phones and semiconductors, as well as challenges in the standards development process itself.) Throughout the article, point-of-care diagnostics are used as an illustrative example. An initiative is already underway to explore standardized diagnostics platforms. Summary This Debate article aims to convince the reader that standards can benefit global health technologies if we learn lessons from other industries. The article draws from historical examples and the authors’ experiences to suggest principles, challenges, and opportunities in developing these standards. If implemented well, standardized platforms can lower barriers to entry, improve affordability, and create a vibrant ecosystem of innovative new global health technologies. PMID:24134866

Seasonal dynamics of bacterial meningitis: a time-series analysis

PubMed Central

Paireau, Juliette; Chen, Angelica; Broutin, Helene; Grenfell, Bryan; Basta, Nicole E

2017-01-01

Summary Background Bacterial meningitis, which is caused mainly by Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae, inflicts a substantial burden of disease worldwide. Yet, the temporal dynamics of this disease are poorly characterised and many questions remain about the ecology of the disease. We aimed to comprehensively assess seasonal trends in bacterial meningitis on a global scale. Methods We developed the first bacterial meningitis global database by compiling monthly incidence data as reported by country-level surveillance systems. Using country-level wavelet analysis, we identified whether a 12 month periodic component (annual seasonality) was detected in time-series that had at least 5 years of data with at least 40 cases reported per year. We estimated the mean timing of disease activity by computing the centre of gravity of the distribution of cases and investigated whether synchrony exists between the three pathogens responsible for most cases of bacterial meningitis. Findings We used country-level data from 66 countries, including from 47 countries outside the meningitis belt in sub-Saharan Africa. A persistent seasonality was detected in 49 (96%) of the 51 time-series from 38 countries eligible for inclusion in the wavelet analyses. The mean timing of disease activity had a latitudinal trend, with bacterial meningitis seasons peaking during the winter months in countries in both the northern and southern hemispheres. The three pathogens shared similar seasonality, but time-shifts differed slightly by country. Interpretation Our findings provide key insight into the seasonal dynamics of bacterial meningitis and add to knowledge about the global epidemiology of meningitis and the host, environment, and pathogen characteristics driving these patterns. Comprehensive understanding of global seasonal trends in meningitis could be used to design more effective prevention and control strategies. Funding Princeton University Health Grand Challenge, US National Institutes of Health (NIH), NIH Fogarty International Center Research and Policy for Infectious Disease Dynamics programme (RAPIDD), Bill & Melinda Gates Foundation. PMID:27198841

A comparative study of interprofessional education in global health care

PubMed Central

Herath, Chulani; Zhou, Yangfeng; Gan, Yong; Nakandawire, Naomie; Gong, Yanghong; Lu, Zuxun

2017-01-01

Abstract Background: The World Health Organization (WHO) and its partners identify interprofessional (IP) collaboration in education and practice as an innovative strategy that plays an important role in mitigating the global health workforce crisis. Evidence on the practice of global health level in interprofessional education (IPE) is scarce and hampered due to the absence of aggregate information. Therefore, this systematic review was conducted to examine the incidences of IPE and summarize the main features about the IPE programs in undergraduate and postgraduate education in developed and developing countries. Methods: The PubMed, Embase, Web of Science, and Google Scholar were searched from their inception to January 31, 2016 for relevant studies regarding the development of IPE worldwide, IPE undergraduate and postgraduate programs, IP interaction in health education, IPE content, clinical placements, and teaching methods. Countries in which a study was conducted were classified as developed and developing countries according to the definition by the United Nations (UN) in 2014. Results: A total of 65 studies from 41 countries met our inclusion criteria, including 45 studies from 25 developed countries and 20 studies from 16 developing countries. Compared with developing countries, developed countries had more IPE initiatives. IPE programs were mostly at the undergraduate level. Overall, the university was the most common academic institution that provided IPE programs. The contents of the curricula were mainly designed to provide IP knowledge, skills, and values that aimed at developing IP competencies. IPE clinical placements were typically based in hospitals, community settings, or both. The didactic and interactive teaching methods varied significantly within and across universities where they conducted IPE programs. Among all health care disciplines, nursing was the discipline that conducted most of the IPE programs. Conclusion: This systematic review illustrated that the IPE programs vary substantially across countries. Many countries, especially the academic institutions are benefiting from the implementation of IPE programs. There is a need to strengthen health education policies at global level aiming at initiating IPE programs in relevant institutions. PMID:28930816

Global universe anisotropy probed by the alignment of structures in the cosmic microwave background.

PubMed

Wiaux, Y; Vielva, P; Martínez-González, E; Vandergheynst, P

2006-04-21

We question the global universe isotropy by probing the alignment of local structures in the cosmic microwave background (CMB) radiation. The original method proposed relies on a steerable wavelet decomposition of the CMB signal on the sphere. The analysis of the first-year Wilkinson Microwave Anisotropy Probe data identifies a mean preferred plane with a normal direction close to the CMB dipole axis, and a mean preferred direction in this plane, very close to the ecliptic poles axis. Previous statistical anisotropy results are thereby synthesized, but further analyses are still required to establish their origin.

Global Justice Protest Events and the Production of Knowledge about Differences

ERIC Educational Resources Information Center

Daro, Vinci E. F.

2009-01-01

Recent social movement activities--in particular, transnationally-coordinated global justice mobilizations--require participants to work across substantial differences in languages, cultural backgrounds, political visions, and organizing traditions. Negotiating such differences is an active, adaptive, and learning-intensive process. In contrast to…

Local properties and global structure of McVittie spacetimes with non-flat Friedmann-Lemaître-Robertson-Walker backgrounds

NASA Astrophysics Data System (ADS)

Nolan, Brien C.

2017-11-01

McVittie spacetimes embed the vacuum Schwarzschild(-(anti) de Sitter) spacetime in an isotropic, Friedmann-Lemaître-Robertson-Walker (FLRW) background universe. The global structure of such spacetimes is well understood when the FLRW background is spatially flat. In this paper, we study the global structure of McVittie spacetimes with spatially non-flat FLRW backgrounds. We derive some basic results on the metric, curvature and matter content of these spacetimes and provide a representation of the metric that makes the study of their global properties possible. In the closed case, we find that at each instant of time, the spacetime is confined to a region bounded by a (positive) minimum and a maximum area radius, and is bounded either to the future or to the past by a scalar curvature singularity. This allowed region only exists when the background scale factor is above a certain minimum, and so is bounded away from the Big Bang singularity, as in the flat case. In the open case, the situation is different, and we focus mainly on this case. In K<0 McVittie spacetimes, radial null geodesics originate in finite affine time in the past at a boundary formed by the union of the Big Bang singularity of the FLRW background and a hypersurface (of varying causal character) which is non-singular in the sense of scalar curvature. Furthermore, in the case of eternally expanding open universes with Λ≥slant0 , we prove that black holes are ubiquitous: ingoing radial null geodesics extend in finite affine time to a hypersurface that forms the boundary of the region from which photons can escape to future null infinity. We determine the structure of the conformal diagrams that can arise in the open case. Finally, we revisit the black hole interpretation of McVittie spacetimes in the spatially flat case, and show that this interpretation holds also in the case of a vanishing cosmological constant, contrary to a previous claim of ours.

A Novel Strategy for Very-Large-Scale Cash-Crop Mapping in the Context of Weather-Related Risk Assessment, Combining Global Satellite Multispectral Datasets, Environmental Constraints, and In Situ Acquisition of Geospatial Data

PubMed Central

Iannelli, Gianni Cristian; Torres, Marco A.

2018-01-01

Cash crops are agricultural crops intended to be sold for profit as opposed to subsistence crops, meant to support the producer, or to support livestock. Since cash crops are intended for future sale, they translate into large financial value when considered on a wide geographical scale, so their production directly involves financial risk. At a national level, extreme weather events including destructive rain or hail, as well as drought, can have a significant impact on the overall economic balance. It is thus important to map such crops in order to set up insurance and mitigation strategies. Using locally generated data—such as municipality-level records of crop seeding—for mapping purposes implies facing a series of issues like data availability, quality, homogeneity, etc. We thus opted for a different approach relying on global datasets. Global datasets ensure homogeneity and availability of data, although sometimes at the expense of precision and accuracy. A typical global approach makes use of spaceborne remote sensing, for which different land cover classification strategies are available in literature at different levels of cost and accuracy. We selected the optimal strategy in the perspective of a global processing chain. Thanks to a specifically developed strategy for fusing unsupervised classification results with environmental constraints and other geospatial inputs including ground-based data, we managed to obtain good classification results despite the constraints placed. The overall production process was composed using “good-enough" algorithms at each step, ensuring that the precision, accuracy, and data-hunger of each algorithm was commensurate to the precision, accuracy, and amount of data available. This paper describes the tailored strategy developed on the occasion as a cooperation among different groups with diverse backgrounds, a strategy which is believed to be profitably reusable in other, similar contexts. The paper presents the problem, the constraints and the adopted solutions; it then summarizes the main findings including that efforts and costs can be saved on the side of Earth Observation data processing when additional ground-based data are available to support the mapping task. PMID:29443919

A Novel Strategy for Very-Large-Scale Cash-Crop Mapping in the Context of Weather-Related Risk Assessment, Combining Global Satellite Multispectral Datasets, Environmental Constraints, and In Situ Acquisition of Geospatial Data.

PubMed

Dell'Acqua, Fabio; Iannelli, Gianni Cristian; Torres, Marco A; Martina, Mario L V

2018-02-14

Cash crops are agricultural crops intended to be sold for profit as opposed to subsistence crops, meant to support the producer, or to support livestock. Since cash crops are intended for future sale, they translate into large financial value when considered on a wide geographical scale, so their production directly involves financial risk. At a national level, extreme weather events including destructive rain or hail, as well as drought, can have a significant impact on the overall economic balance. It is thus important to map such crops in order to set up insurance and mitigation strategies. Using locally generated data-such as municipality-level records of crop seeding-for mapping purposes implies facing a series of issues like data availability, quality, homogeneity, etc. We thus opted for a different approach relying on global datasets. Global datasets ensure homogeneity and availability of data, although sometimes at the expense of precision and accuracy. A typical global approach makes use of spaceborne remote sensing, for which different land cover classification strategies are available in literature at different levels of cost and accuracy. We selected the optimal strategy in the perspective of a global processing chain. Thanks to a specifically developed strategy for fusing unsupervised classification results with environmental constraints and other geospatial inputs including ground-based data, we managed to obtain good classification results despite the constraints placed. The overall production process was composed using "good-enough" algorithms at each step, ensuring that the precision, accuracy, and data-hunger of each algorithm was commensurate to the precision, accuracy, and amount of data available. This paper describes the tailored strategy developed on the occasion as a cooperation among different groups with diverse backgrounds, a strategy which is believed to be profitably reusable in other, similar contexts. The paper presents the problem, the constraints and the adopted solutions; it then summarizes the main findings including that efforts and costs can be saved on the side of Earth Observation data processing when additional ground-based data are available to support the mapping task.

Ethnomedicine and dominant medicine in multicultural Australia: a critical realist reflection on the case of Korean-Australian immigrants in Sydney

PubMed Central

Han, Gil-Soo; Ballis, Harry

2007-01-01

Background Viewed through the micro focus of an interpretive lens, medical anthropology remains mystified because interpretivist explanations seriously downplay the given context in which individual health seeking-behaviours occur. This paper draws upon both the interpretivist and political economy perspectives to reflect on the ethno medical practices within the Korean-Australian community in Sydney. Methods We draw on research data collected between 1995 and 1997 for an earlier study of the use of biomedical and traditional medicine by Korean-Australians in Sydney. A total of 120 interviews were conducted with a range of participants, including biomedical doctors, traditional health professionals, Korean community leaders and Korean migrants representing a range of socio-economic backgrounds and migration patterns. Results and Discussion First, the paper highlights the extent to which the social location of migrants in a host society alters or restructures their initial cultural practices they bring with them. Second, taking hanbang medicine in the Korean-Australian community as an illustrative case, the paper explores the transformation of the dominant biomedicine in Australia as a result of the influx of ethnomedicine in the era of global capitalism and global movement. Conclusion In seeking to explain the popularity and supply of alternative health care, it is important to go beyond the culture of each kind of health care itself and to take into consideration the changes occurring at societal, national and global levels as well as consequential individual response to the changes. New social conditions influence the choice of health care methods, including herbal/alternative medicine, health foods and what are often called New Age therapies. PMID:17201916

Hybrid active contour model for inhomogeneous image segmentation with background estimation

NASA Astrophysics Data System (ADS)

Sun, Kaiqiong; Li, Yaqin; Zeng, Shan; Wang, Jun

2018-03-01

This paper proposes a hybrid active contour model for inhomogeneous image segmentation. The data term of the energy function in the active contour consists of a global region fitting term in a difference image and a local region fitting term in the original image. The difference image is obtained by subtracting the background from the original image. The background image is dynamically estimated from a linear filtered result of the original image on the basis of the varying curve locations during the active contour evolution process. As in existing local models, fitting the image to local region information makes the proposed model robust against an inhomogeneous background and maintains the accuracy of the segmentation result. Furthermore, fitting the difference image to the global region information makes the proposed model robust against the initial contour location, unlike existing local models. Experimental results show that the proposed model can obtain improved segmentation results compared with related methods in terms of both segmentation accuracy and initial contour sensitivity.

Background radioactivity in sediments near Los Alamos, New Mexico.

PubMed

McLin, Stephen G

2004-07-26

River and reservoir sediments have been collected annually by Los Alamos National Laboratory since 1974 and 1979, respectively. These background samples are collected from five river stations and four reservoirs located throughout northern New Mexico and southern Colorado. Analyses include 3H, 90Sr, 137Cs, total U, 238Pu, 239,240Pu, 241Am, gross alpha, gross beta, and gross gamma radioactivity. Surprisingly, there are no federal or state regulatory standards in the USA that specify how to compute background radioactivity values on sediments. Hence, the sample median (or 0.50 quantile) is proposed for this background because it reflects central data tendency and is distribution-free. Estimates for the upper limit of background radioactivity on river and reservoir sediments are made for sampled analytes using the 0.95 quantile (two-tail). These analyses also show that seven of ten analytes from reservoir sediments are normally distributed, or are normally distributed after a logarithmic or square root transformation. However, only three of ten analytes from river sediments are similarly distributed. In addition, isotope ratios for 137Cs/238Pu, 137Cs/239,240Pu, and 239,240Pu/238Pu from reservoir sediments are independent of clay content, total organic carbon/specific surface area (TOC/SSA) and cation exchange capacity/specific surface area (CEC/SSA) ratios. These TOC/SSA and CEC/SSA ratios reflect sediment organic carbon and surface charge densities that are associated with radionuclide absorption, adsorption, and ion exchange reactions on clay mineral structures. These latter ratio values greatly exceed the availability of background radionuclides in the environment, and insure that measured background levels are a maximum. Since finer-grained reservoir sediments contain larger clay-sized fractions compared to coarser river sediments, they show higher background levels for most analytes. Furthermore, radioactivity values on reservoir sediments have remained relatively constant since the early 1980s. These results suggest that clay contents in terrestrial sediments are often more important at concentrating background radionuclides than many other environmental factors, including geology, climate and vegetation. Hence, reservoirs and floodplains represent ideal radionuclide sampling locations because fine-grained materials are more easily trapped here. Ultimately, most of these differences still reflect spatial and temporal variability originating from global atmospheric nuclear weapons testing and disintegration of nuclear-powered satellites upon atmospheric reentry. Copyright 2004 Elsevier B.V.

Atmospheric pCO2 reconstructed across five early Eocene global warming events

NASA Astrophysics Data System (ADS)

Cui, Ying; Schubert, Brian A.

2017-11-01

Multiple short-lived global warming events, known as hyperthermals, occurred during the early Eocene (56-52 Ma). Five of these events - the Paleocene-Eocene Thermal Maximum (PETM or ETM1), H1 (or ETM2), H2, I1, and I2 - are marked by a carbon isotope excursion (CIE) within both marine and terrestrial sediments. The magnitude of CIE, which is a function of the amount and isotopic composition of carbon added to the ocean-atmosphere system, varies significantly between marine versus terrestrial substrates. Here we use the increase in carbon isotope fractionation by C3 land plants in response to increased pCO2 to reconcile this difference and reconstruct a range of background pCO2 and peak pCO2 for each CIE, provided two potential carbon sources: methane hydrate destabilization and permafrost-thawing/organic matter oxidation. Although the uncertainty on each pCO2 estimate using this approach is low (e.g., median uncertainty = + 23% / - 18%), this work highlights the potential for significant systematic bias in the pCO2 estimate resulting from sampling resolution, substrate type, diagenesis, and environmental change. Careful consideration of each of these factors is required especially when applying this approach to a single marine-terrestrial CIE pair. Given these limitations, we provide an upper estimate for background early Eocene pCO2 of 463 +248/-131 ppmv (methane hydrate scenario) to 806 +127/-104 ppmv (permafrost-thawing/organic matter oxidation scenario). These results, which represent the first pCO2 proxy estimates directly tied to the Eocene hyperthermals, demonstrate that early Eocene warmth was supported by background pCO2 less than ∼3.5× preindustrial levels and that pCO2 > 1000 ppmv may have occurred only briefly, during hyperthermal events.

Impact of scatterometer wind (ASCAT-A/B) data assimilation on semi real-time forecast system at KIAPS

NASA Astrophysics Data System (ADS)

Han, H. J.; Kang, J. H.

2016-12-01

Since Jul. 2015, KIAPS (Korea Institute of Atmospheric Prediction Systems) has been performing the semi real-time forecast system to assess the performance of their forecast system as a NWP model. KPOP (KIAPS Protocol for Observation Processing) is a part of KIAPS data assimilation system and has been performing well in KIAPS semi real-time forecast system. In this study, due to the fact that KPOP would be able to treat the scatterometer wind data, we analyze the effect of scatterometer wind (ASCAT-A/B) on KIAPS semi real-time forecast system. O-B global distribution and statistics of scatterometer wind give use two information which are the difference between background field and observation is not too large and KPOP processed the scatterometer wind data well. The changes of analysis increment because of O-B global distribution appear remarkably at the bottom of atmospheric field. It also shows that scatterometer wind data cover wide ocean where data would be able to short. Performance of scatterometer wind data can be checked through the vertical error reduction against IFS between background and analysis field and vertical statistics of O-A. By these analysis result, we can notice that scatterometer wind data will influence the positive effect on lower level performance of semi real-time forecast system at KIAPS. After, long-term result based on effect of scatterometer wind data will be analyzed.

Allocating Scarce Resources Strategically - An Evaluation and Discussion of the Global Fund's Pattern of Disbursements

PubMed Central

McCoy, David; Kinyua, Kelvin

2012-01-01

Background The Global Fund is under pressure to improve its rationing of financial support. This study describes the GF's pattern of disbursements in relation to total health expenditure (THE), government health expenditure (GHE), income status and the burden of HIV/AIDS, TB and malaria. It also examines the potential for recipient countries to increase domestic public financing for health. Methods This is a cross-sectional study of 104 countries that received Global Fund disbursements in 2009. It analyses data on Global Fund disbursements; health financing indicators; government revenue and expenditure; and burden of disease. Findings Global Fund disbursements made up 0.37% of THE across all 104 countries; but with considerable country variation ranging from 0.002% to 53.4%. Global Fund disbursements to government amounted to 0.47% of GHE across the 104 countries, but again with considerable variation (in three countries more than half of GHE was based on Global Fund support). Although the Global Fund provides progressively more funding for lower income countries on average, there is much variation at the country such that here was no correlation between per capita GF disbursements and per capita THE, nor between per capita GF disbursement to government and per capita GHE. There was only a slight positive correlation between per capita GF disbursement and burden of disease. Several countries with a high degree of 'financial dependency' upon the Fund have the potential to increase levels of domestic financing for health. Discussion The Global Fund can improve its targeting of resources so that it better matches the pattern of global need. To do this it needs to: a) reduce the extent to which funds are allocated on a demand-driven basis; and b) align its funding model to broader health systems financing and patterns of health expenditure beyond the three diseases. PMID:22590496

Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects

PubMed Central

Wiegers, Maike; Walter, Martin; Abler, Birgit; Graf, Heiko

2016-01-01

Background: Various psychiatric populations are currently investigated with resting state fMRI, with the aim of individualizing diagnostics and treatment options and improving treatment outcomes. Many of these studies are conducted in large naturalistic samples, providing rich insights regarding disease-related neural alterations, but with the common psychopharmacological medication limiting interpretations of the results. We therefore investigated the effects of common noradrenergic and anti-dopaminergic medications on local and global resting state activity (rs-activity) in healthy volunteers to further the understanding of the respective effects independent from disease-related alterations. Methods: Within a randomized, double-blind, placebo-controlled crossover design, we investigated 19 healthy male subjects by resting state fMRI after the intake of reboxetine (4mg/d), amisulpride (200mg/d), and placebo for 7 days each. Treatment-related differences in local and global rs-activity were measured by the fractional amplitude of low frequency fluctuations (fALFF) and resting state functional connectivity (rs-FC). Results: fALFF revealed alterations of local rs-activity within regions of the core noradrenergic pathway, including the locus coeruleus under reboxetine, correlated with its plasma levels. Moreover, reboxetine led to increased rs-FC between regions within this pathway, i.e. the locus coeruleus, tectum, thalamus, and amygdala. Amisulpride modulated local rs-activity of regions within the dopaminergic pathway, with the altered signal in the putamen correlating with amisulpride plasma levels. Correspondingly, amisulpride increased rs-FC between regions of the dopaminergic pathway comprising the substantia nigra and putamen. Conclusion: Our data provide evidence of how psychopharmacological agents alter local and global rs-activity within the respective neuroanatomical pathways in healthy subjects, which may help with interpreting data in psychiatric populations. PMID:26209860

3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models

PubMed Central

2013-01-01

Background The spatial organization of the genome is being evaluated as a novel indicator of toxicity in conjunction with drug-induced global DNA hypomethylation and concurrent chromatin reorganization. 3D quantitative DNA methylation imaging (3D-qDMI) was applied as a cell-by-cell high-throughput approach to investigate this matter by assessing genome topology through represented immunofluorescent nuclear distribution patterns of 5-methylcytosine (MeC) and global DNA (4,6-diamidino-2-phenylindole = DAPI) in labeled nuclei. Methods Differential progression of global DNA hypomethylation was studied by comparatively dosing zebularine (ZEB) and 5-azacytidine (AZA). Treated and untreated (control) human prostate and liver cancer cells were subjected to confocal scanning microscopy and dedicated 3D image analysis for the following features: differential nuclear MeC/DAPI load and codistribution patterns, cell similarity based on these patterns, and corresponding differences in the topology of low-intensity MeC (LIM) and low in intensity DAPI (LID) sites. Results Both agents generated a high fraction of similar MeC phenotypes across applied concentrations. ZEB exerted similar effects at 10–100-fold higher drug concentrations than its AZA analogue: concentration-dependent progression of global cytosine demethylation, validated by measuring differential MeC levels in repeat sequences using MethyLight, and the concurrent increase in nuclear LIM densities correlated with cellular growth reduction and cytotoxicity. Conclusions 3D-qDMI demonstrated the capability of quantitating dose-dependent drug-induced spatial progression of DNA demethylation in cell nuclei, independent from interphase cell-cycle stages and in conjunction with cytotoxicity. The results support the notion of DNA methylation topology being considered as a potential indicator of causal impacts on chromatin distribution with a conceivable application in epigenetic drug toxicology. PMID:23394161

Funding for malaria control 2006–2010: A comprehensive global assessment

PubMed Central

2012-01-01

Background The last decade has seen a dramatic increase in international and domestic funding for malaria control, coupled with important declines in malaria incidence and mortality in some regions of the world. As the ongoing climate of financial uncertainty places strains on investment in global health, there is an increasing need to audit the origin, recipients and geographical distribution of funding for malaria control relative to populations at risk of the disease. Methods A comprehensive review of malaria control funding from international donors, bilateral sources and national governments was undertaken to reconstruct total funding by country for each year 2006 to 2010. Regions at risk from Plasmodium falciparum and/or Plasmodium vivax transmission were identified using global risk maps for 2010 and funding was assessed relative to populations at risk. Those nations with unequal funding relative to a regional average were identified and potential explanations highlighted, such as differences in national policies, government inaction or donor neglect. Results US$8.9 billion was disbursed for malaria control and elimination programmes over the study period. Africa had the largest levels of funding per capita-at-risk, with most nations supported primarily by international aid. Countries of the Americas, in contrast, were supported typically through national government funding. Disbursements and government funding in Asia were far lower with a large variation in funding patterns. Nations with relatively high and low levels of funding are discussed. Conclusions Global funding for malaria control is substantially less than required. Inequity in funding is pronounced in some regions particularly when considering the distinct goals of malaria control and malaria elimination. Efforts to sustain and increase international investment in malaria control should be informed by evidence-based assessment of funding equity. PMID:22839432

The Global Energy Budget.

ERIC Educational Resources Information Center

Jax, Daniel W.

1992-01-01

Presents a lesson plan about greenhouse effect and global warming. Includes diagrams and graphs from which students are asked to make inferences. Provides background information about how energy enters and leaves the earth system, the energy budget, consequences of obstructing the energy balance, and the greenhouse effect. (three references) (MCO)

Preparing Students for the Global Workplace: The Impact of a Semester Abroad

ERIC Educational Resources Information Center

Jackson, Jane

2015-01-01

As the world becomes increasingly interconnected, employers are seeking "global-ready graduates," that is, individuals with an intercultural mindset, who can interact effectively and appropriately with people from diverse linguistic and cultural backgrounds. In response, tertiary institutions are creating more opportunities for…

Neoliberalism and the Future for a Socio-Educative Physical Education

ERIC Educational Resources Information Center

Evans, John

2014-01-01

Background: This paper represents the Discussant's response to the variety of papers presented to the "AIESEP-ICSEMIS" symposium entitled: "School Physical Education Curricula for Future Generations: Global Patterns? Global Lessons? Glasgow, Glasgow 19-24 July 2012." Purpose: With reference to the symposium papers, this paper…

Global plagues and the Global Fund: Challenges in the fight against HIV, TB and malaria

PubMed Central

Tan, Darrell HS; Upshur, Ross EG; Ford, Nathan

2003-01-01

Background Although a grossly disproportionate burden of disease from HIV/AIDS, TB and malaria remains in the Global South, these infectious diseases have finally risen to the top of the international agenda in recent years. Ideal strategies for combating these diseases must balance the advantages and disadvantages of 'vertical' disease control programs and 'horizontal' capacity-building approaches. Discussion The Global Fund to Fight AIDS, Tuberculosis and Malaria (GFATM) represents an important step forward in the struggle against these pathogens. While its goals are laudable, significant barriers persist. Most significant is the pitiful lack of funds committed by world governments, particularly those of the very G8 countries whose discussions gave rise to the Fund. A drastic scaling up of resources is the first clear requirement for the GFATM to live up to the international community's lofty intentions. A directly related issue is that of maintaining a strong commitment to the treatment of the three diseases along with traditional prevention approaches, with the ensuing debates over providing affordable access to medications in the face of the pharmaceutical industry's vigorous protection of patent rights. Summary At this early point in the Fund's history, it remains to be seen how these issues will be resolved at the programming level. Nevertheless, it is clear that significant structural changes are required in such domains as global spending priorities, debt relief, trade policy, and corporate responsibility. HIV/AIDS, tuberculosis and malaria are global problems borne of gross socioeconomic inequality, and their solutions require correspondingly geopolitical solutions. PMID:12667262

Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

NASA Astrophysics Data System (ADS)

Kwon, H.; Kang, J.-S.; Jo, Y.; Kang, J. H.

2014-11-01

The Korea Institute of Atmospheric Prediction Systems (KIAPS) has been developing a new global numerical weather prediction model and an advanced data assimilation system. As part of the KIAPS Package for Observation Processing (KPOP) system for data assimilation, preprocessing and quality control modules for bending angle measurements of global positioning system radio occultation (GPS-RO) data have been implemented and examined. GPS-RO data processing system is composed of several steps for checking observation locations, missing values, physical values for Earth radius of curvature, and geoid undulation. An observation-minus-background check is implemented by use of a one-dimensional observational bending angle operator and tangent point drift is also considered in the quality control process. We have tested GPS-RO observations utilized by the Korean Meteorological Administration (KMA) within KPOP, based on both the KMA global model and the National Center for Atmospheric Research (NCAR) Community Atmosphere Model-Spectral Element (CAM-SE) as a model background. Background fields from the CAM-SE model are incorporated for the preparation of assimilation experiments with the KIAPS-LETKF data assimilation system, which has been successfully implemented to a cubed-sphere model with fully unstructured quadrilateral meshes. As a result of data processing, the bending angle departure statistics between observation and background shows significant improvement. Also, the first experiment in assimilating GPS-RO bending angle resulting from KPOP within KIAPS-LETKF shows encouraging results.

Globalization of diabetes: the role of diet, lifestyle, and genes.

PubMed

Hu, Frank B

2011-06-01

Type 2 diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. Fueled by rapid urbanization, nutrition transition, and increasingly sedentary lifestyles, the epidemic has grown in parallel with the worldwide rise in obesity. Asia's large population and rapid economic development have made it an epicenter of the epidemic. Asian populations tend to develop diabetes at younger ages and lower BMI levels than Caucasians. Several factors contribute to accelerated diabetes epidemic in Asians, including the "normal-weight metabolically obese" phenotype; high prevalence of smoking and heavy alcohol use; high intake of refined carbohydrates (e.g., white rice); and dramatically decreased physical activity levels. Poor nutrition in utero and in early life combined with overnutrition in later life may also play a role in Asia's diabetes epidemic. Recent advances in genome-wide association studies have contributed substantially to our understanding of diabetes pathophysiology, but currently identified genetic loci are insufficient to explain ethnic differences in diabetes risk. Nonetheless, interactions between Westernized diet and lifestyle and genetic background may accelerate the growth of diabetes in the context of rapid nutrition transition. Epidemiologic studies and randomized clinical trials show that type 2 diabetes is largely preventable through diet and lifestyle modifications. Translating these findings into practice, however, requires fundamental changes in public policies, the food and built environments, and health systems. To curb the escalating diabetes epidemic, primary prevention through promotion of a healthy diet and lifestyle should be a global public policy priority.

Globalization of Diabetes

PubMed Central

2011-01-01

Type 2 diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. Fueled by rapid urbanization, nutrition transition, and increasingly sedentary lifestyles, the epidemic has grown in parallel with the worldwide rise in obesity. Asia's large population and rapid economic development have made it an epicenter of the epidemic. Asian populations tend to develop diabetes at younger ages and lower BMI levels than Caucasians. Several factors contribute to accelerated diabetes epidemic in Asians, including the “normal-weight metabolically obese” phenotype; high prevalence of smoking and heavy alcohol use; high intake of refined carbohydrates (e.g., white rice); and dramatically decreased physical activity levels. Poor nutrition in utero and in early life combined with overnutrition in later life may also play a role in Asia's diabetes epidemic. Recent advances in genome-wide association studies have contributed substantially to our understanding of diabetes pathophysiology, but currently identified genetic loci are insufficient to explain ethnic differences in diabetes risk. Nonetheless, interactions between Westernized diet and lifestyle and genetic background may accelerate the growth of diabetes in the context of rapid nutrition transition. Epidemiologic studies and randomized clinical trials show that type 2 diabetes is largely preventable through diet and lifestyle modifications. Translating these findings into practice, however, requires fundamental changes in public policies, the food and built environments, and health systems. To curb the escalating diabetes epidemic, primary prevention through promotion of a healthy diet and lifestyle should be a global public policy priority. PMID:21617109

Children inhibit global information when the forest is dense and local information when the forest is sparse.

PubMed

Krakowski, Claire-Sara; Borst, Grégoire; Vidal, Julie; Houdé, Olivier; Poirel, Nicolas

2018-09-01

Visual environments are composed of global shapes and local details that compete for attentional resources. In adults, the global level is processed more rapidly than the local level, and global information must be inhibited in order to process local information when the local information and global information are in conflict. Compared with adults, children present less of a bias toward global visual information and appear to be more sensitive to the density of local elements that constitute the global level. The current study aimed, for the first time, to investigate the key role of inhibition during global/local processing in children. By including two different conditions of global saliency during a negative priming procedure, the results showed that when the global level was salient (dense hierarchical figures), 7-year-old children and adults needed to inhibit the global level to process the local information. However, when the global level was less salient (sparse hierarchical figures), only children needed to inhibit the local level to process the global information. These results confirm a weaker global bias and the greater impact of saliency in children than in adults. Moreover, the results indicate that, regardless of age, inhibition of the most salient hierarchical level is systematically required to select the less salient but more relevant level. These findings have important implications for future research in this area. Copyright © 2018 Elsevier Inc. All rights reserved.

Morphology of Dwarf Galaxies in Isolated Satellite Systems

NASA Astrophysics Data System (ADS)

Ann, Hong Bae

2017-08-01

The environmental dependence of the morphology of dwarf galaxies in isolated satellite systems is analyzed to understand the origin of the dwarf galaxy morphology using the visually classified morphological types of 5836 local galaxies with z ≲ 0.01. We consider six sub-types of dwarf galaxies, dS0, dE, dE_{bc}, dSph, dE_{blue}, and dI, of which the first four sub-types are considered as early-type and the last two as late-type. The environmental parameters we consider are the projected distance from the host galaxy (r_{p}), local and global background densities, and the host morphology. The spatial distributions of dwarf satellites of early-type galaxies are much different from those of dwarf satellites of late-type galaxies, suggesting the host morphology combined with r_{p} plays a decisive role on the morphology of the dwarf satellite galaxies. The local and global background densities play no significant role on the morphology of dwarfs in the satellite systems hosted by early-type galaxies. However, in the satellite system hosted by late-type galaxies, the global background densities of dE and dSph satellites are significantly different from those of dE_{bc}, dE_{blue}, and dI satellites. The blue-cored dwarf satellites (dE_{bc}) of early-type galaxies are likely to be located at r_{p} > 0.3 Mpc to keep their cold gas from the ram pressure stripping by the hot corona of early-type galaxies. The spatial distribution of dE_{bc} satellites of early-type galaxies and their global background densities suggest that their cold gas is intergalactic material accreted before they fall into the satellite systems.

Overseas Contingency Operations Funding: Background and Status

DTIC Science & Technology

2017-02-07

emergency” or “Overseas Contingency Operation/ Global War on Terror” (OCO/GWOT) requirement in annual agency budget requests—or both. Funds designated as...to be excluded from budget control limits. The BCA added the designation “Overseas Contingency Operation/ Global War on Terror” to the BBEDCA...been largely provided through supplemental appropriation acts or has been designated as an “emergency” or “overseas contingency operation/ global war on

Force Projection, Strategic Agility and the Big Meltdown

DTIC Science & Technology

2001-05-18

UNLIMITED Number of Pages 29 ii Abstract of FORCE PROJECTION, STRATEGIC AGILITY AND THE BIG MELTDOWN Due to global warming , the polar icepack which...INTRODUCTION The polar icecap which covers the Arctic Ocean is melting. It is a well-known, scientific fact. Global warming is the generally...operational factors and functions, as applicable. 3 CHAPTER II BACKGROUND Global Warming and the Arctic During this and the last century, researchers have

A reduction in the asymmetry of ENSO amplitude due to global warming: The role of atmospheric feedback

NASA Astrophysics Data System (ADS)

Ham, Yoo-Geun

2017-08-01

This study analyzes a reduction in the asymmetry of El Niño Southern-Oscillation (ENSO) amplitude due to global warming in Coupled Model Intercomparison Project Phase 5 models. The multimodel-averaged Niño3 skewness during December-February season decreased approximately 40% in the RCP4.5 scenario compared to that in the historical simulation. The change in the nonlinear relationship between sea surface temperature (SST) and precipitation is a key factor for understanding the reduction in ENSO asymmetry due to global warming. In the historical simulations, the background SST leading to the greatest precipitation sensitivity (SST for Maximum Precipitation Sensitivity, SST_MPS) occurs when the positive SST anomaly is located over the equatorial central Pacific. Therefore, an increase in climatological SST due to global warming weakens the atmospheric response during El Niño over the central Pacific. However, the climatological SST over this region in the historical simulation is still lower than the SST_MPS for the negative SST anomaly; therefore, a background SST increase due to global warming can further increase precipitation sensitivity. The atmospheric feedbacks during La Niña are enhanced and increase the La Niña amplitude due to global warming.

From satellite altimetry to operational oceanography and Argo: three revolutions in oceanography (Fridtjof Nansen Medal Lecture)

NASA Astrophysics Data System (ADS)

Le Traon, P. Y.

2012-04-01

The launch of the US/French mission Topex/Poseidon (T/P) (CNES/NASA) in August 1992 was the start of a revolution in oceanography. For the first time, a very precise altimeter system optimized for large scale sea level and ocean circulation observations was flying. Topex/Poseidon revolutionized our vision and understanding of the ocean. It provided new views of the large scale seasonal and interannual sea level and ocean circulation variations. T/P alone could not observe the mesoscale circulation. In the 1990s, the ESA satellites ERS-1/2 were flying simultaneously with T/P. The ERS-1/2 orbit was well adapted for mesoscale circulation sampling but the orbit determination and altimeter performance were much less precise than for T/P. We demonstrated that we could use T/P as a reference mission for ERS-1/2 and bring the ERS-1/2 data to an accuracy level comparable to T/P. This was an essential first step for the merging of T/P and ERS-1/2. The second step required the development of a global optimal interpolation method. Near real time high resolution global sea level anomaly maps were then derived. These maps have been operationally produced as part of the SSALTO/DUACS system for the last 15 years. They are now widely used by the oceanographic community and have contributed to a much better understanding and recognition of the role and importance of mesoscale dynamics. The unique capability of satellite altimetry to observe the global ocean in near real time at high resolution was essential to the development of global ocean forecasting, a second revolution in oceanography. The Global Ocean Data Assimilation Experiment (GODAE) (1998-2008) was phased with the T/P and ERS-1/2 successors (Jason-1 and ENVISAT) and was instrumental in the development of global operational oceanography capabilities. Europe played a leading role in GODAE. In 1998, the global in-situ observing system was inadequate for the global scope of GODAE. This led to the development of Argo, an initial joint venture between CLIVAR and GODAE. Argo has been an outstanding success. The 3000 Argo profiling floats now provide the most important global in-situ observations to monitor and understand the role of the ocean on the earth climate. This is a third revolution in oceanography. I was lucky enough to be involved with many colleagues and friends in these three revolutions or breakthroughs in oceanography. The presentation will provide some historical background on the development of the SSALTO/DUACS merged altimeter products and an overview of their utility and use for ocean research and operational oceanography. I will thengo throughthe development of operational oceanography and Argo over the past 15 years focussing on European contributions, in particular, in the framework of the GMES Marine Service, EuroGOOSand the Euro-Argo research infrastructure. Perspectives and new challenges for the integrated global ocean observing system will be finally discussed.

SERE: Single-parameter quality control and sample comparison for RNA-Seq

PubMed Central

2012-01-01

Background Assessing the reliability of experimental replicates (or global alterations corresponding to different experimental conditions) is a critical step in analyzing RNA-Seq data. Pearson’s correlation coefficient r has been widely used in the RNA-Seq field even though its statistical characteristics may be poorly suited to the task. Results Here we present a single-parameter test procedure for count data, the Simple Error Ratio Estimate (SERE), that can determine whether two RNA-Seq libraries are faithful replicates or globally different. Benchmarking shows that the interpretation of SERE is unambiguous regardless of the total read count or the range of expression differences among bins (exons or genes), a score of 1 indicating faithful replication (i.e., samples are affected only by Poisson variation of individual counts), a score of 0 indicating data duplication, and scores >1 corresponding to true global differences between RNA-Seq libraries. On the contrary the interpretation of Pearson’s r is generally ambiguous and highly dependent on sequencing depth and the range of expression levels inherent to the sample (difference between lowest and highest bin count). Cohen’s simple Kappa results are also ambiguous and are highly dependent on the choice of bins. For quantifying global sample differences SERE performs similarly to a measure based on the negative binomial distribution yet is simpler to compute. Conclusions SERE can therefore serve as a straightforward and reliable statistical procedure for the global assessment of pairs or large groups of RNA-Seq datasets by a single statistical parameter. PMID:23033915

The African Diaspora: History, Adaptation and Health

PubMed Central

Rotimi, Charles N.; Tekola-Ayele, Fasil; Baker, Jennifer L.; Shriner, Daniel

2017-01-01

The trans-Atlantic slave trade brought millions of Africans to the New World. Advances in genomics are providing novel insights into the history and health of Africans and the diasporan populations. Recent examples reviewed here include the unraveling of substantial hunter-gatherer and “Eurasian” admixtures across sub-Saharan Africa, expanding our understanding of ancestral African genetics; the global ubiquity of mixed ancestry; the revealing of African ancestry in Latin Americans that likely derived from the slave trade; and understanding of the ancestral backgrounds of APOL1 and LPL found to influence kidney disease and lipid levels, respectively, providing specific insights into disease etiology and health disparities. PMID:27644073

Social exclusion in academia through biases in methodological quality evaluation: On the situation of women in science and philosophy.

PubMed

Leuschner, Anna

2015-12-01

Empirical studies show that academia is socially exclusive. I argue that this social exclusion works, at least partly, through the systematic methodological disqualification of contributions from members of underrepresented social groups. As methodological quality criteria are underdetermined their interpretation and weighting can be biased with relation to gender, race, social background, etc. Such biased quality evaluation can take place on a local or global level. The current situation of women in academic philosophy illuminates this. I conclude that only mechanical solutions can effectively change the situation. Copyright © 2015 Elsevier Ltd. All rights reserved.

Measurement of high altitude air quality using aircraft

NASA Technical Reports Server (NTRS)

Rudey, R. A.; Perkins, P. J.

1973-01-01

The minor atmospheric constituents associated with and affected by aircraft exhaust emissions at altitudes from 6 to 20 km will be monitored in flight programs presently being implemented. Preliminary in situ data are available from flight tests of dedicated instruments to be used in these programs. A Global Atmospheric Sampling Program using Boeing 747 airliners was determined to be feasible in studies conducted by airlines and airframe companies. Worldwide monitoring in the troposphere and the lower stratosphere is planned. Stratospheric air sampling on a more local basis will be done with a U2 aircraft. Measuring system evaluations and improvements have been required to detect the low background levels.

Power System Analysis

NASA Astrophysics Data System (ADS)

Taniguchi, Haruhito

Electric power generation that relies on various sources as the primary sources of energy is expected to bring down CO2 emissions levels to support the overall strategy to curb global warming. Accordingly, utilities are moving towards integrating more renewable sources for generation, mostly dispersed, and adopting Smart Grid Technologies for system control. In order to construct, operate, and maintain power systems stably and economically in such background, thorough understanding about the characteristics of power systems and their components is essential. This paper presents modeling and simulation techniques available for the analysis of critical aspects such as thermal capacity, stability, voltage stability, and frequency dynamics, vital for the stable operation of power systems.

Measurement of high-altitude air quality using aircraft.

NASA Technical Reports Server (NTRS)

Rudey, R. A.; Perkins, P. J.

1973-01-01

The minor atmospheric constituents associated with and affected by aircraft exhaust emissions at altitudes from 6 to 20 km will be monitored in flight programs presently being implemented. Preliminary in situ data are available from flight tests of dedicated instruments to be used in these programs. A Global Atmospheric Sampling Program using Boeing 747 airliners was determined to be feasible in studies conducted by airlines and airframe companies. Worldwide monitoring in the troposphere and the lower stratosphere is planned. Stratospheric air sampling on a more local basis will be done with a U2 aircraft. Measuring system evaluations and improvements have been required to detect the low background levels.

Burnout among general hospital mental health professionals and the salutogenic approach.

PubMed

Rabin, Stanley; Shorer, Yuval; Nadav, Meir; Guez, Jonathan; Hertzanu, Mali; Shiber, Asher

2011-01-01

Professionals working in mental health often exhibit high levels of strain leading to poor psychological wellbeing, emotional exhaustion and depletion of personal resources. Even under tight global economic conditions preventing burnout should be given high priority among mental health providers. This paper looks at the wide spectrum of stressors found in specialists working in the mental health area and examines, with the salutogenic approach in the background, ways to relieve professional burnout among general hospital mental health providers. Guidelines for managers and staff to alleviate their professional strain are suggested so as to improve the quality of life in the workplace.

The African diaspora: history, adaptation and health.

PubMed

Rotimi, Charles N; Tekola-Ayele, Fasil; Baker, Jennifer L; Shriner, Daniel

2016-12-01

The trans-Atlantic slave trade brought millions of Africans to the New World. Advances in genomics are providing novel insights into the history and health of Africans and the diasporan populations. Recent examples reviewed here include the unraveling of substantial hunter-gatherer and 'Eurasian' admixtures across sub-Saharan Africa, expanding our understanding of ancestral African genetics; the global ubiquity of mixed ancestry; the revealing of African ancestry in Latin Americans that likely derived from the slave trade; and understanding of the ancestral backgrounds of APOL1 and LPL found to influence kidney disease and lipid levels, respectively, providing specific insights into disease etiology and health disparities. Published by Elsevier Ltd.

Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk

PubMed Central

Tang, W. H. Wilson; Wang, Zeneng; Cho, Leslie; Brennan, Danielle M.; Hazen, Stanley L.

2009-01-01

Objective We hypothesized that an integrated assessment of arginine with its catabolic products may better predict cardiovascular risks than arginine levels alone. Background Arginine is the sole nitrogen source for nitric oxide (NO) synthesis. The major catabolic products of arginine are ornithine and citrulline. Methods Plasma levels of free arginine, ornithine, citrulline and the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) were measured using LC/MS/MS. We examined the relationship of global arginine bioavailability ratio (GABR, defined as arginine/[ornithine+citrulline]) vs. arginine and its catabolic metabolites to prevalence of coronary artery disease (CAD) and incidence of major adverse cardiovascular events (MACE = death, myocardial infarction, stroke) over a 3-year follow-up in 1,010 subjects undergoing elective cardiac catheterization. Results Patients with CAD had significantly lower GABR [median(IQR); 1.06(0.75, 1.31) versus 1.27(0.96, 1.73), p<0.001] and arginine levels [mean: 68 ±20 μM versus 74 ±24 μM, p<0.001) than those without CAD. After adjusting for Framingham risk score, C-reactive protein, and renal function, lower GABR (but not arginine levels) and higher citrulline levels remained significantly associated with both prevalence of CAD [adjusted odds-ratio (OR) 3.93, p<0.001 and 5.98, p<0.001, respectively] and 3-year risk for incidence of MACE [adjusted Hazard ratio (HR) 1.98, p=0.025 and 2.40, p=0.01, respectively], and remained significant after adjusting for ADMA. Conclusions GABR may serve as a more comprehensive concept of reduced NO synthetic capacity compared to systemic arginine levels. Diminished GABR and high citrulline levels are associated with both development of atherosclerotic CAD and heightened long-term risk for major adverse cardiac events. PMID:19477356

Late Life Leisure Activities and Risk of Cognitive Decline

PubMed Central

2013-01-01

Background. Studies concerning the effect of different types of leisure activities on various cognitive domains are limited. This study tests the hypothesis that mental, physical, and social activities have a domain-specific protection against cognitive decline. Methods. A cohort of a geographically defined population in China was examined in 2003–2005 and followed for an average of 2.4 years. Leisure activities were assessed in 1,463 adults aged 65 years and older without cognitive or physical impairment at baseline, and their cognitive performances were tested at baseline and follow-up examinations. Results. High level of mental activity was related to less decline in global cognition (β = −.23, p < .01), language (β = −.11, p < .05), and executive function (β = −.13, p < .05) in ANCOVA models adjusting for age, gender, education, history of stroke, body mass index, Apolipoprotein E genotype, and baseline cognition. High level of physical activity was related to less decline in episodic memory (β = −.08, p < .05) and language (β = −.15, p < .01). High level of social activity was associated with less decline in global cognition (β = −.11, p < .05). Further, a dose-response pattern was observed: although participants who did not engage in any of the three activities experienced a significant global cognitive decline, those who engaged in any one of the activities maintained their cognition, and those who engaged in two or three activities improved their cognition. The same pattern was observed in men and in women. Conclusions. Leisure activities in old age may protect against cognitive decline for both women and men, and different types of activities seem to benefit different cognitive domains. PMID:22879456

Thoron (220Rn) in the indoor environment and work places

NASA Astrophysics Data System (ADS)

Ramachandran, T. V.; Sahoo, B. K.

2009-08-01

Ever since studies on uranium miners established the presence of a positive risk coefficient for the occurrence of lung cancer in miners exposed to elevated levels of 222Rn and its progeny, there was a great upsurge of interest in the measurement of 222Rn in the environment. Subsequently, considerable data is being generated on the levels of 222Rn in the environment across the worlds and is being periodically reported by UNSCEAR reports. In contrast to this, data pertaining to 220Rn in indoors and workplace environment is scaree due to the genral perception that its levels are negligible due to its shorter half life, and subsequently its contribution to the total inhalation dose is ignored, in the presence of other significant sources of natural radiation. This may not be true. Globally many locations have higher levels of natural background radiation due to elevated levels of primordial radio nuclides in the soil and their decay products like radon (222Rn), and thoron (220Rn) in the environment. Of late, technologically enhanced naturally occurring radioactive material has also contributed to the burden of background radiation. It is estimated that inhalation of 222Rn, 220Rn and their short lived progenies contribute more than 54% of the total natural background radiation dose received by the general population. 220Rn problem exists in industries which use thorium nitrate. Including India, lamps using thoriated gas mantles are still being used for indoor and outdoor lighting and by hawkers in rural as well as urban areas. Considering the fact that large amount of thorium nitrate is being handled by these industries, contribution to the inhalation dose of workers from 220Rn gas emanated and build up of the progeny in ambient air may also be quite significant. In this paper current status of 220Rn levels in the indoor environment and workplaces as well as in other industries where large amount of 232Th is being handled is being summarized. Methods of measurement and reported levels are also summarized.

Measuring the degree of integration for an integrated service network

PubMed Central

Ye, Chenglin; Browne, Gina; Grdisa, Valerie S; Beyene, Joseph; Thabane, Lehana

2012-01-01

Background Integration involves the coordination of services provided by autonomous agencies and improves the organization and delivery of multiple services for target patients. Current measures generally do not distinguish between agencies’ perception and expectation. We propose a method for quantifying the agencies’ service integration. Using the data from the Children’s Treatment Network (CTN), we aimed to measure the degree of integration for the CTN agencies in York and Simcoe. Theory and methods We quantified the integration by the agreement between perceived and expected levels of involvement and calculated four scores from different perspectives for each agency. We used the average score to measure the global network integration and examined the sensitivity of the global score. Results Most agencies’ integration scores were <65%. As measured by the agreement between every other agency’s perception and expectation, the overall integration of CTN in Simcoe and York was 44% (95% CI: 39%–49%) and 52% (95% CI: 48%–56%), respectively. The sensitivity analysis showed that the global scores were robust. Conclusion Our method extends existing measures of integration and possesses a good extent of validity. We can also apply the method in monitoring improvement and linking integration with other outcomes. PMID:23593050

Wheat production in Bangladesh: its future in the light of global warming

PubMed Central

Hossain, Akbar; Teixeira da Silva, Jaime A.

2012-01-01

Background and aims The most fundamental activity of the people of Bangladesh is agriculture. Modelling projections for Bangladesh indicate that warmer temperatures linked to climate change will severely reduce the growth of various winter crops (wheat, boro rice, potato and winter vegetables) in the north and central parts. In summer, crops in south-eastern parts of the country are at risk from increased flooding as sea levels increase. Key facts Wheat is one of the most important winter crops and is temperature sensitive and the second most important grain crop after rice. In this review, we provide an up-to-date and detailed account of wheat research of Bangladesh and the impact that global warming may have on agriculture, especially wheat production. Although flooding is not of major importance or consequence to the wheat crop at present, some perspectives are provided on this stress since wheat is flood sensitive and the incidence of flooding is likely to increase. Projections This information and projections will allow wheat breeders to devise new breeding programmes to attempt to mitigate future global warming. We discuss what this implies for food security in the broader context of South Asia. PMID:23304431

The global distribution of Crimean-Congo hemorrhagic fever

PubMed Central

Messina, Jane P.; Pigott, David M.; Golding, Nick; Duda, Kirsten A.; Brownstein, John S.; Weiss, Daniel J.; Gibson, Harry; Robinson, Timothy P.; Gilbert, Marius; William Wint, G. R.; Nuttall, Patricia A.; Gething, Peter W.; Myers, Monica F.; George, Dylan B.; Hay, Simon I.

2015-01-01

Background Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne infection caused by a virus (CCHFV) from the Bunyaviridae family. Domestic and wild vertebrates are asymptomatic reservoirs for the virus, putting animal handlers, slaughter-house workers and agricultural labourers at highest risk in endemic areas, with secondary transmission possible through contact with infected blood and other bodily fluids. Human infection is characterized by severe symptoms that often result in death. While it is known that CCHFV transmission is limited to Africa, Asia and Europe, definitive global extents and risk patterns within these limits have not been well described. Methods We used an exhaustive database of human CCHF occurrence records and a niche modeling framework to map the global distribution of risk for human CCHF occurrence. Results A greater proportion of shrub or grass land cover was the most important contributor to our model, which predicts highest levels of risk around the Black Sea, Turkey, and some parts of central Asia. Sub-Saharan Africa shows more focalized areas of risk throughout the Sahel and the Cape region. Conclusions These new risk maps provide a valuable starting point for understanding the zoonotic niche of CCHF, its extent and the risk it poses to humans. PMID:26142451

Patient socioeconomic determinants of the choice of generic versus brand name drugs in the context of a reference price system: evidence from Belgian prescription data.

PubMed

Farfan-Portet, Maria-Isabel; Van de Voorde, Carine; Vrijens, France; Vander Stichele, Robert

2012-06-01

The generic reference price system (RPS) can impose a financial penalty for patients using a brand name drug instead of its generic alternative. Previous studies on the impact of the RPS have not considered the potentially differential effect of using generic alternatives for individuals with a different socioeconomic background. However, patients' characteristics might determine their overall knowledge of the existence of the system and thus of the financial burden to which they may be confronted. The association between patients' characteristics and the use of generic drugs versus brand name drugs was analyzed for ten highly prescribed pharmaceutical molecules included in the Belgian generic reference price system. Prescriptions were obtained from a 10% sample of all general practitioners in 2008 (corresponding to 120,670 adult patients and 368,101 prescriptions). For each pharmaceutical molecule, logistic regression models were performed, with independent variables for patient socioeconomic background at the individual level (work status, having a guaranteed income and being entitled to increased reimbursement of co-payments) and at the level of the neighborhood (education). The percentage of generic prescriptions ranged from 24.7 to 76.4%, and the mean reference supplement in 2008 ranged from €4.3 to €37.8. For seven molecules, higher use of a generic alternative was associated with either having a guaranteed income, with receiving increased reimbursement of co-payments or with living in areas with the lowest levels of education. Globally, results provided evidence that the generic RPS in Belgium does not lead to a higher financial burden on individuals from a low socioeconomic background.

Sources of interference in item and associative recognition memory.

PubMed

Osth, Adam F; Dennis, Simon

2015-04-01

A powerful theoretical framework for exploring recognition memory is the global matching framework, in which a cue's memory strength reflects the similarity of the retrieval cues being matched against the contents of memory simultaneously. Contributions at retrieval can be categorized as matches and mismatches to the item and context cues, including the self match (match on item and context), item noise (match on context, mismatch on item), context noise (match on item, mismatch on context), and background noise (mismatch on item and context). We present a model that directly parameterizes the matches and mismatches to the item and context cues, which enables estimation of the magnitude of each interference contribution (item noise, context noise, and background noise). The model was fit within a hierarchical Bayesian framework to 10 recognition memory datasets that use manipulations of strength, list length, list strength, word frequency, study-test delay, and stimulus class in item and associative recognition. Estimates of the model parameters revealed at most a small contribution of item noise that varies by stimulus class, with virtually no item noise for single words and scenes. Despite the unpopularity of background noise in recognition memory models, background noise estimates dominated at retrieval across nearly all stimulus classes with the exception of high frequency words, which exhibited equivalent levels of context noise and background noise. These parameter estimates suggest that the majority of interference in recognition memory stems from experiences acquired before the learning episode. (c) 2015 APA, all rights reserved).

Global Interoperability of Broadband Networks (GIBN): Project Overview

NASA Technical Reports Server (NTRS)

DePaula, Ramon P.

1998-01-01

Various issues associated with the Global Interoperability of Broadband Networks (GIBN) are presented in viewgraph form. Specific topics include GIBN principles, objectives and goals, and background. GIBN/NASA status, the Transpacific High Definition Video experiment, GIBN experiment selection criteria, satellite industry involvement, and current experiments associated with GIBN are also discussed.

Globalization, Social Movements, and Education

ERIC Educational Resources Information Center

Cortina, Regina

2011-01-01

Background/Context: This essay is a part of a special issue that emerges from a year-long faculty seminar at Teachers College, Columbia University. The seminar's purpose has been to examine in fresh terms the nexus of globalization, education, and citizenship. Participants come from diverse fields of research and practice, among them art…

Marine and Coastal Resources. Global Issues Education Packet.

ERIC Educational Resources Information Center

Holm, Amy E.

At least 70% of the Earth is covered with water. This packet provides background information on eight areas of concern regarding marine and coastal resources. Considered are: (1) "Coastal Resources"; (2) "Mangroves"; (3) "Coral Reefs"; (4) "Ocean Resources"; (5) "Aquaculture"; (6) "Pollution"; (7) "Marine Debris"; and (8) "The Global Commons."…

Global climate anomalies and potential infectious disease risks: 2014-2015

USDA-ARS?s Scientific Manuscript database

Background: The El Niño/Southern Oscillation (ENSO) is a global climate phenomenon that impacts human infectious disease risk worldwide through droughts, floods, and other climate extremes. Throughout summer and fall 2014, El Niño Watch, issued by the US National Oceanic and Atmospheric Administrat...

Managing Global Problems.

ERIC Educational Resources Information Center

Stanley, C. Maxwell

The book examines the historical background of and accomplishments in seven global problem areas. It is hypothesized that effective management within today's framework is the only way to progress toward the political and economic order that is necessary to assure peace and security, justice, and human rights, and to improve the quality of life. It…

Mini Schools: The New "Global City Communities" of Vancouver

ERIC Educational Resources Information Center

Yoon, Ee-Seul

2011-01-01

In recent decades, under the mutually constitutive processes of neoliberal urbanization and globalization, Vancouver has radically transformed and become a serious contender for the title of "world-class city". Against the background of this socio-spatial force reconfiguring the city, I explore how the city's unique development of…

Dreaming of Holistic Adult Education in 2020

ERIC Educational Resources Information Center

Giraldo, Monica Arboleda

2007-01-01

Would projections about adult education look different if they were made by people from multiple countries, backgrounds, and perspectives? The author believes that no matter how much global knowledge one has, interpretations and projections would be different and would be influenced by those aspects already mentioned. Trying to think globally as…

Higher levels of depression are associated with reduced global bias in visual processing.

PubMed

de Fockert, Jan W; Cooper, Andrew

2014-04-01

Negative moods have been associated with a tendency to prioritise local details in visual processing. The current study investigated the relation between depression and visual processing using the Navon task, a standard task of local and global processing. In the Navon task, global stimuli are presented that are made up of many local parts, and the participants are instructed to report the identity of either a global or a local target shape. Participants with a low self-reported level of depression showed evidence of the expected global processing bias, and were significantly faster at responding to the global, compared with the local level. By contrast, no such difference was observed in participants with high levels of depression. The reduction of the global bias associated with high levels of depression was only observed in the overall speed of responses to global (versus local) targets, and not in the level of interference produced by the global (versus local) distractors. These results are in line with recent findings of a dissociation between local/global processing bias and interference from local/global distractors, and support the claim that depression is associated with a reduction in the tendency to prioritise global-level processing.

The German Excellence Initiative: Update. Go8 Backgrounder 24a

ERIC Educational Resources Information Center

Frohlich, Ellen

2012-01-01

As described in "Go8 Backgrounder 24: Answering the Global Challenge--Experiences from European Excellence Initiatives," Germany began a debate about how to strengthen its position as an excellent location for science and research in 2004. This debate focussed in particular on the competitiveness of the country's universities and…

The Influence of Low-carbon Economy on Global Trade Pattern

NASA Astrophysics Data System (ADS)

Xiao-jing, Guo

Since global warming has seriously endangered the living environment of human being and their health and safety, the development of low-carbon economy has become an irreversible global trend. Under the background of economic globalization, low-carbon economy will surely exert a significant impact on global trade pattern. Countries are paying more and more attention to the green trade. The emission permits trade of carbon between the developed countries and the developing countries has become more mature than ever. The carbon tariff caused by the distribution of the "big cake" will make the low-cost advantage in developing countries cease to exist, which will, in turn, affect the foreign trade, economic development, employment and people's living in developing countries. Therefore, under the background of this trend, we should perfect the relevant laws and regulations on trade and environment as soon as possible, optimize trade structure, promote greatly the development of service trade, transform thoroughly the mode of development in foreign trade, take advantage of the international carbon trading market by increasing the added value of export products resulted from technological innovation to achieve mutual benefit and win-win results and promote common development.

A study on the birth and globalization of sports originated from each continent

PubMed Central

Lee, Byung Jin; Kim, Tae Young

2016-01-01

The purpose of this research is to see how continent specific sports rose to its modern-day status through globalization. This research focuses on the historical background of how England’s football, America’s national pastime, baseball, Japan’s Judo, and Korea’s Taekwondo developed into sports in addition to the reasoning behind its globalization. Promoted by England and the rest of the European continent, Soccer is considered to be one of the world’s most popular sports and has served its function as a form of cultural imperialism. It has also advanced alongside commerce, missionary work and other types of cultural clashes. In America, baseball was used to integrate its multicultural society and developed so that the team captain leads the rest of his team. The sports of Oriental countries were reborn through modernization that was influenced by the modern rationality, education etc. of its Western counterparts. Judo and Taekwondo were introduced globally through the Olympic Games. As mentioned above the birth of sporting events has a close connection to a nation’s cultural background and globalization has taken different forms depending on which continent it originated from. PMID:26933653

Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010

PubMed Central

Blencowe, Hannah; Lawn, Joy E.; Vazquez, Thomas; Fielder, Alistair; Gilbert, Clare

2013-01-01

Background: Retinopathy of prematurity (ROP) is a leading cause of potentially avoidable childhood blindness worldwide. We estimated ROP burden at the global and regional levels to inform screening and treatment programs, research, and data priorities. Methods: Systematic reviews and meta-analyses were undertaken to estimate the risk of ROP and subsequent visual impairment for surviving preterm babies by level of neonatal care, access to ROP screening, and treatment. A compartmental model was used to estimate ROP cases and numbers of visually impaired survivors. Results: In 2010, an estimated 184,700 (uncertainty range: 169,600–214,500) preterm babies developed any stage of ROP, 20,000 (15,500–27,200) of whom became blind or severely visually impaired from ROP, and a further 12,300 (8,300–18,400) developed mild/moderate visual impairment. Sixty-five percent of those visually impaired from ROP were born in middle-income regions; 6.2% (4.3–8.9%) of all ROP visually impaired infants were born at >32-wk gestation. Visual impairment from other conditions associated with preterm birth will affect larger numbers of survivors. Conclusion: Improved care, including oxygen delivery and monitoring, for preterm babies in all facility settings would reduce the number of babies affected with ROP. Improved data tracking and coverage of locally adapted screening/treatment programs are urgently required. PMID:24366462

Spatial frequency characteristics at image decision-point locations for observers with different radiological backgrounds in lung nodule detection

NASA Astrophysics Data System (ADS)

Pietrzyk, Mariusz W.; Manning, David J.; Dix, Alan; Donovan, Tim

2009-02-01

Aim: The goal of the study is to determine the spatial frequency characteristics at locations in the image of overt and covert observers' decisions and find out if there are any similarities in different observers' groups: the same radiological experience group or the same accuracy scored level. Background: The radiological task is described as a visual searching decision making procedure involving visual perception and cognitive processing. Humans perceive the world through a number of spatial frequency channels, each sensitive to visual information carried by different spatial frequency ranges and orientations. Recent studies have shown that particular physical properties of local and global image-based elements are correlated with the performance and the level of experience of human observers in breast cancer and lung nodule detections. Neurological findings in visual perception were an inspiration for wavelet applications in vision research because the methodology tries to mimic the brain processing algorithms. Methods: The wavelet approach to the set of postero-anterior chest radiographs analysis has been used to characterize perceptual preferences observers with different levels of experience in the radiological task. Psychophysical methodology has been applied to track eye movements over the image, where particular ROIs related to the observers' fixation clusters has been analysed in the spaces frame by Daubechies functions. Results: Significance differences have been found between the spatial frequency characteristics at the location of different decisions.

Impact of local and non-local sources of pollution on background US Ozone: synergy of a low-earth orbiting and geostationary sounder constellation

NASA Astrophysics Data System (ADS)

Bowman, K. W.; Lee, M.

2015-12-01

Dramatic changes in the global distribution of emissions over the last decade have fundamentally altered source-receptor pollution impacts. A new generation of low-earth orbiting (LEO) sounders complimented by geostationary sounders over North America, Europe, and Asia providing a unique opportunity to quantify the current and future trajectory of emissions and their impact on global pollution. We examine the potential of this constellation of air quality sounders to quantify the role of local and non-local sources of pollution on background ozone in the US. Based upon an adjoint sensitivity method, we quantify the role synoptic scale transport of non-US pollution on US background ozone over months representative of different source-receptor relationships. This analysis allows us distinguish emission trajectories from megacities, e.g. Beijing, or regions, e.g., western China, from natural trends on downwind ozone. We subsequently explore how a combination of LEO and GEO observations could help quantify the balance of local emissions against changes in distant sources . These results show how this unprecedented new international ozone observing system can monitor the changing structure of emissions and their impact on global pollution.

A Model for Teaching a Climate Change Elective Science Course at the Community College Level

NASA Astrophysics Data System (ADS)

Mandia, S. A.

2012-12-01

The impact of global climate change is far-reaching, both for humanity and for the environment. It is essential that our students be provided a strong scientific background for the role of natural and human caused climate change so that they are better prepared to become involved in the discussion. Here the author reveals a successful model designed for use with a diverse student body at the community college level. Teaching strategies beyond the traditional lecture and exam style include: web-based resources such as static websites along with dynamic blogging tools, post-lecture cooperative learning review sessions, weekly current event research projects, use of rubrics to assist students in their own project evaluation before submission, and a research paper utilizing the Skeptical Science website to examine the validity of the most common climate change myths.

Decoding DNA, RNA and peptides with quantum tunnelling

NASA Astrophysics Data System (ADS)

di Ventra, Massimiliano; Taniguchi, Masateru

2016-02-01

Drugs and treatments could be precisely tailored to an individual patient by extracting their cellular- and molecular-level information. For this approach to be feasible on a global scale, however, information on complete genomes (DNA), transcriptomes (RNA) and proteomes (all proteins) needs to be obtained quickly and at low cost. Quantum mechanical phenomena could potentially be of value here, because the biological information needs to be decoded at an atomic level and quantum tunnelling has recently been shown to be able to differentiate single nucleobases and amino acids in short sequences. Here, we review the different approaches to using quantum tunnelling for sequencing, highlighting the theoretical background to the method and the experimental capabilities demonstrated to date. We also explore the potential advantages of the approach and the technical challenges that must be addressed to deliver practical quantum sequencing devices.

Design of a portable dose rate detector based on a double Geiger-Mueller counter

NASA Astrophysics Data System (ADS)

Wang, Peng; Tang, Xiao-Bin; Gong, Pin; Huang, Xi; Wen, Liang-Sheng; Han, Zhen-Yang; He, Jian-Ping

2018-01-01

A portable dose rate detector was designed to monitor radioactive pollution and radioactive environments. The portable dose detector can measure background radiation levels (0.1 μSv/h) to nuclear accident radiation levels (>10 Sv/h). Both automatic switch technology of a double Geiger-Mueller counter and time-to-count technology were adopted to broaden the measurement range of the instrument. Global positioning systems and the 3G telecommunication protocol were installed to prevent radiation damage to the human body. In addition, the Monte Carlo N-Particle code was used to design the thin layer of metal for energy compensation, which was used to flatten energy response The portable dose rate detector has been calibrated by the standard radiation field method, and it can be used alone or in combination with additional radiation detectors.

Spacecraft applications of advanced global positioning system technology

NASA Technical Reports Server (NTRS)

1988-01-01

This is the final report on the Texas Instruments Incorporated (TI) simulations study of Spacecraft Application of Advanced Global Positioning System (GPS) Technology. This work was conducted for the NASA Johnson Space Center (JSC) under contract NAS9-17781. GPS, in addition to its baselined capability as a highly accurate spacecraft navigation system, can provide traffic control, attitude control, structural control, and uniform time base. In Phase 1 of this program, another contractor investigated the potential of GPS in these four areas and compared GPS to other techniques. This contract was for the Phase 2 effort, to study the performance of GPS for these spacecraft applications through computer simulations. TI had previously developed simulation programs for GPS differential navigation and attitude measurement. These programs were adapted for these specific spacecraft applications. In addition, TI has extensive expertise in the design and production of advanced GPS receivers, including space-qualified GPS receivers. We have drawn on this background to augment the simulation results in the system level overview, which is Section 2 of this report.

PFC Emissions from Detected Versus Nondetected Anode Effects in the Aluminum Industry

NASA Astrophysics Data System (ADS)

Wong, David S.; Fraser, Paul; Lavoie, Pascal; Kim, Jooil

2015-02-01

Perfluorinated carbon compounds (PFCs) CF4 and C2F6 are potent greenhouse gases that are generated in aluminum reduction cells during events known as anode effects (AEs). Since the 1990s, the aluminum industry has made considerable progress in reducing PFCs from conventionally defined and detected AEs. However in recent years, the industry has noted the presence of unaccounted PFCs that are generated outside the conventional AE definition. Two additional AE categories have been proposed, namely low-voltage, propagating AEs (LVP-AEs) and nonpropagating AEs (NP-AEs) that relate to continuous, background levels of PFC emissions. These unaccounted PFC phenomena may help explain the recent discrepancy between industry accounting and atmospheric measurements of global PFC emissions. Estimates from AGAGE, a global network of atmospheric observatories, suggest as much as 50% underaccounting of PFCs by the aluminum industry in the 2006-2010 period. The following work reviews this discrepancy and the potential role played by LVP-AEs and NP-AEs.

Looking into the Earth

NASA Astrophysics Data System (ADS)

Mussett, Alan E.; Aftab Khan, M.; Button, Illustrated By Sue

2000-12-01

Looking Into the Earth comprehensively describes the principles and applications of both `global' and `exploration' geophysics on all scales. It forms an introduction to geophysics suitable for those who do not necessarily intend to become professional geophysicists, including geologists, civil engineers, environmental scientists, and field archaeologists. The book is organised into two parts: Part 1 describes the geophysical methods, while Part 2 illustrates their use in a number of extended case histories. Mathematical and physical principles are introduced at an elementary level, and then developed as necessary. Student questions and exercises are included at the end of each chapter. The book is aimed primarily at introductory and intermediate university students taking courses in geology, earth science, environmental science, and engineering. It will also form an excellent introductory textbook in geophysics departments, and will help practising geologists, archaeologists and engineers understand what geophysics can offer their work. Accessible to students with little background in maths and physics Covers both global and applied geophysics Well illustrated and contains many student exercises and case studies Written by experienced teachers of geophysics

Locations of Joint Physical Activity in Parent-Child Pairs Based on Accelerometer and GPS Monitoring

PubMed Central

Dunton, Genevieve Fridlund; Liao, Yue; Almanza, Estela; Jerrett, Micheal; Spruijt-Metz, Donna; Pentz, Mary Ann

2012-01-01

Background Parental factors may play an important role in influencing children’s physical activity levels. Purpose This cross-sectional study sought to describe the locations of joint physical activity among parents and children. Methods Parent-child pairs (N = 291) wore an Actigraph GT2M accelerometer and GlobalSat BT-335 Global Positioning Systems (GPS) device over the same 7-day period. Children were ages 8–14 years. Joint behavior was defined by a linear separation distance of less than 50m between parent and child. Land use classifications were assigned to GPS data points. Results Joint physical activity was spread across residential locations (35%), and commercial venues (24%), and open spaces/parks (20%). Obese children and parents performed less joint physical activity in open spaces/parks than under/normal weight children and parents (p’s < .01). Conclusions Understanding where joint parent-child physical activity naturally occurs may inform location-based interventions to promote these behaviors. PMID:23011914

CTBT infrasound network performance to detect the 2013 Russian fireball event

DOE PAGES

Pilger, Christoph; Ceranna, Lars; Ross, J. Ole; ...

2015-03-18

The explosive fragmentation of the 2013 Chelyabinsk meteorite generated a large airburst with an equivalent yield of 500 kT TNT. It is the most energetic event recorded by the infrasound component of the Comprehensive Nuclear-Test-Ban Treaty-International Monitoring System (CTBT-IMS), globally detected by 20 out of 42 operational stations. This study performs a station-by-station estimation of the IMS detection capability to explain infrasound detections and nondetections from short to long distances, using the Chelyabinsk meteorite as global reference event. Investigated parameters influencing the detection capability are the directivity of the line source signal, the ducting of acoustic energy, and the individualmore » noise conditions at each station. Findings include a clear detection preference for stations perpendicular to the meteorite trajectory, even over large distances. Only a weak influence of stratospheric ducting is observed for this low-frequency case. As a result, a strong dependence on the diurnal variability of background noise levels at each station is observed, favoring nocturnal detections.« less

Space-based observations of megacity carbon dioxide

NASA Astrophysics Data System (ADS)

Kort, Eric A.; Frankenberg, Christian; Miller, Charles E.; Oda, Tom

2012-09-01

Urban areas now house more than half the world's population, and are estimated to contribute over 70% of global energy-related CO2 emissions. Many cities have emission reduction policies in place, but lack objective, observation-based methods for verifying their outcomes. Here we demonstrate the potential of satellite-borne instruments to provide accurate global monitoring of megacity CO2 emissions using GOSAT observations of column averaged CO2 dry air mole fraction (XCO2) collected over Los Angeles and Mumbai. By differencing observations over the megacity with those in nearby background, we observe robust, statistically significant XCO2 enhancements of 3.2 ± 1.5 ppm for Los Angeles and 2.4 ± 1.2 ppm for Mumbai, and find these enhancements can be exploited to track anthropogenic emission trends over time. We estimate that XCO2 changes as small as 0.7 ppm in Los Angeles, corresponding to a 22% change in emissions, could be detected with GOSAT at the 95% confidence level.

Interannual Variability and Trends of CH4, CO and OH Using the Computationally-Efficient CH4-CO-OH (ECCOH) Module

NASA Technical Reports Server (NTRS)

Elshorbany, Yasin F.; Duncan, Bryan N.; Strode, Sarah A.; Wang, James S.; Kouatchou, Jules

2015-01-01

Methane (CH4) is the second most important anthropogenic greenhouse gas (GHG). Its 100-year global warming potential (GWP) is 34 times larger than that for carbon dioxide. The 100-year integrated GWPof CH4 is sensitive to changes in hydroxyl radical (OH) levels.Oxidation of CH4 and carbon monoxide (CO) by OH is the main loss process, thus affecting the oxidizing capacity of the atmosphere and contributing to the global ozone background. Limitations of using archived, monthly OH fields for studies of methane's and COs evolution are that feedbacks of the CH4-CO-OH system on methane, CO and OH are not captured. In this study, we employ the computationally Efficient CH4-CO-OH (ECCOH) module (Elshorbany et al., 2015) to investigate the nonlinear feedbacks of the CH4-CO-OH system on the interannual variability and trends of the CH4, CO, OH system.

Limitations to Thermoregulation and Acclimatization Challenge Human Adaptation to Global Warming

PubMed Central

Hanna, Elizabeth G.; Tait, Peter W.

2015-01-01

Human thermoregulation and acclimatization are core components of the human coping mechanism for withstanding variations in environmental heat exposure. Amidst growing recognition that curtailing global warming to less than two degrees is becoming increasing improbable, human survival will require increasing reliance on these mechanisms. The projected several fold increase in extreme heat events suggests we need to recalibrate health protection policies and ratchet up adaptation efforts. Climate researchers, epidemiologists, and policy makers engaged in climate change adaptation and health protection are not commonly drawn from heat physiology backgrounds. Injecting a scholarly consideration of physiological limitations to human heat tolerance into the adaptation and policy literature allows for a broader understanding of heat health risks to support effective human adaptation and adaptation planning. This paper details the physiological and external environmental factors that determine human thermoregulation and acclimatization. We present a model to illustrate the interrelationship between elements that modulate the physiological process of thermoregulation. Limitations inherent in these processes, and the constraints imposed by differing exposure levels, and thermal comfort seeking on achieving acclimatization, are then described. Combined, these limitations will restrict the likely contribution that acclimatization can play in future human adaptation to global warming. We postulate that behavioral and technological adaptations will need to become the dominant means for human individual and societal adaptations as global warming progresses. PMID:26184272

Methodological Framework for World Health Organization Estimates of the Global Burden of Foodborne Disease

PubMed Central

Devleesschauwer, Brecht; Haagsma, Juanita A.; Angulo, Frederick J.; Bellinger, David C.; Cole, Dana; Döpfer, Dörte; Fazil, Aamir; Fèvre, Eric M.; Gibb, Herman J.; Hald, Tine; Kirk, Martyn D.; Lake, Robin J.; Maertens de Noordhout, Charline; Mathers, Colin D.; McDonald, Scott A.; Pires, Sara M.; Speybroeck, Niko; Thomas, M. Kate; Torgerson, Paul R.; Wu, Felicia; Havelaar, Arie H.; Praet, Nicolas

2015-01-01

Background The Foodborne Disease Burden Epidemiology Reference Group (FERG) was established in 2007 by the World Health Organization to estimate the global burden of foodborne diseases (FBDs). This paper describes the methodological framework developed by FERG's Computational Task Force to transform epidemiological information into FBD burden estimates. Methods and Findings The global and regional burden of 31 FBDs was quantified, along with limited estimates for 5 other FBDs, using Disability-Adjusted Life Years in a hazard- and incidence-based approach. To accomplish this task, the following workflow was defined: outline of disease models and collection of epidemiological data; design and completion of a database template; development of an imputation model; identification of disability weights; probabilistic burden assessment; and estimating the proportion of the disease burden by each hazard that is attributable to exposure by food (i.e., source attribution). All computations were performed in R and the different functions were compiled in the R package 'FERG'. Traceability and transparency were ensured by sharing results and methods in an interactive way with all FERG members throughout the process. Conclusions We developed a comprehensive framework for estimating the global burden of FBDs, in which methodological simplicity and transparency were key elements. All the tools developed have been made available and can be translated into a user-friendly national toolkit for studying and monitoring food safety at the local level. PMID:26633883

Measurement and subtraction of Schumann resonances at gravitational-wave interferometers

NASA Astrophysics Data System (ADS)

Coughlin, Michael W.; Cirone, Alessio; Meyers, Patrick; Atsuta, Sho; Boschi, Valerio; Chincarini, Andrea; Christensen, Nelson L.; De Rosa, Rosario; Effler, Anamaria; Fiori, Irene; Gołkowski, Mark; Guidry, Melissa; Harms, Jan; Hayama, Kazuhiro; Kataoka, Yuu; Kubisz, Jerzy; Kulak, Andrzej; Laxen, Michael; Matas, Andrew; Mlynarczyk, Janusz; Ogawa, Tsutomu; Paoletti, Federico; Salvador, Jacobo; Schofield, Robert; Somiya, Kentaro; Thrane, Eric

2018-05-01

Correlated magnetic noise from Schumann resonances threatens to contaminate the observation of a stochastic gravitational-wave background in interferometric detectors. In previous work, we reported on the first effort to eliminate global correlated noise from the Schumann resonances using Wiener filtering, demonstrating as much as a factor of two reduction in the coherence between magnetometers on different continents. In this work, we present results from dedicated magnetometer measurements at the Virgo and KAGRA sites, which are the first results for subtraction using data from gravitational-wave detector sites. We compare these measurements to a growing network of permanent magnetometer stations, including at the LIGO sites. We show the effect of mutual magnetometer attraction, arguing that magnetometers should be placed at least one meter from one another. In addition, for the first time, we show how dedicated measurements by magnetometers near to the interferometers can reduce coherence to a level consistent with uncorrelated noise, making a potential detection of a stochastic gravitational-wave background possible.

The Weakly Nonlinear Magnetorotational Instability in a Global, Cylindrical Taylor–Couette Flow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, S. E.; Oishi, Jeffrey S., E-mail: seclark@astro.columbia.edu

We conduct a global, weakly nonlinear analysis of the magnetorotational instability (MRI) in a Taylor–Couette flow. This is a multiscale, perturbative treatment of the nonideal, axisymmetric MRI near threshold, subject to realistic radial boundary conditions and cylindrical geometry. We analyze both the standard MRI, initialized by a constant vertical background magnetic field, and the helical MRI, with an azimuthal background field component. This is the first weakly nonlinear analysis of the MRI in a global Taylor–Couette geometry, as well as the first weakly nonlinear analysis of the helical MRI. We find that the evolution of the amplitude of the standardmore » MRI is described by a real Ginzburg–Landau equation (GLE), whereas the amplitude of the helical MRI takes the form of a complex GLE. This suggests that the saturated state of the helical MRI may itself be unstable on long spatial and temporal scales.« less

Observation-Corrected Precipitation Estimates in GEOS-5

NASA Technical Reports Server (NTRS)

Reichle, Rolf H.; Liu, Qing

2014-01-01

Several GEOS-5 applications, including the GEOS-5 seasonal forecasting system and the MERRA-Land data product, rely on global precipitation data that have been corrected with satellite and or gauge-based precipitation observations. This document describes the methodology used to generate the corrected precipitation estimates and their use in GEOS-5 applications. The corrected precipitation estimates are derived by disaggregating publicly available, observationally based, global precipitation products from daily or pentad totals to hourly accumulations using background precipitation estimates from the GEOS-5 atmospheric data assimilation system. Depending on the specific combination of the observational precipitation product and the GEOS-5 background estimates, the observational product may also be downscaled in space. The resulting corrected precipitation data product is at the finer temporal and spatial resolution of the GEOS-5 background and matches the observed precipitation at the coarser scale of the observational product, separately for each day (or pentad) and each grid cell.

Probabilistic assessment of sea level during the last interglacial stage.

PubMed

Kopp, Robert E; Simons, Frederik J; Mitrovica, Jerry X; Maloof, Adam C; Oppenheimer, Michael

2009-12-17

With polar temperatures approximately 3-5 degrees C warmer than today, the last interglacial stage (approximately 125 kyr ago) serves as a partial analogue for 1-2 degrees C global warming scenarios. Geological records from several sites indicate that local sea levels during the last interglacial were higher than today, but because local sea levels differ from global sea level, accurately reconstructing past global sea level requires an integrated analysis of globally distributed data sets. Here we present an extensive compilation of local sea level indicators and a statistical approach for estimating global sea level, local sea levels, ice sheet volumes and their associated uncertainties. We find a 95% probability that global sea level peaked at least 6.6 m higher than today during the last interglacial; it is likely (67% probability) to have exceeded 8.0 m but is unlikely (33% probability) to have exceeded 9.4 m. When global sea level was close to its current level (>or=-10 m), the millennial average rate of global sea level rise is very likely to have exceeded 5.6 m kyr(-1) but is unlikely to have exceeded 9.2 m kyr(-1). Our analysis extends previous last interglacial sea level studies by integrating literature observations within a probabilistic framework that accounts for the physics of sea level change. The results highlight the long-term vulnerability of ice sheets to even relatively low levels of sustained global warming.

Effect of Diabetes Mellitus Type 2 on Salivary Glucose – A Systematic Review and Meta-Analysis of Observational Studies

PubMed Central

Mascarenhas, Paulo; Fatela, Bruno; Barahona, Isabel

2014-01-01

Background Early screening of type 2 diabetes mellitus (DM) is essential for improved prognosis and effective delay of clinical complications. However, testing for high glycemia often requires invasive and painful blood testing, limiting its large-scale applicability. We have combined new, unpublished data with published data comparing salivary glucose levels in type 2 DM patients and controls and/or looked at the correlation between salivary glucose and glycemia/HbA1c to systematically review the effectiveness of salivary glucose to estimate glycemia and HbA1c. We further discuss salivary glucose as a biomarker for large-scale screening of diabetes or developing type 2 DM. Methods and Findings We conducted a meta-analysis of peer-reviewed published articles that reported data regarding mean salivary glucose levels and/or correlation between salivary glucose levels and glycemia or HbA1c for type 2 DM and non-diabetic individuals and combined them with our own unpublished results. Our global meta-analysis of standardized mean differences on salivary glucose levels shows an overall large positive effect of type 2 DM over salivary glucose (Hedge's g = 1.37). The global correlation coefficient (r) between salivary glucose and glycemia was large (r = 0.49), with subgroups ranging from medium (r = 0.30 in non-diabetics) to very large (r = 0.67 in diabetics). Meta-analysis of the global correlation between salivary glucose and HbA1c showed an overall association of medium strength (r = 0.37). Conclusions Our systematic review reports an overall meaningful salivary glucose concentration increase in type 2 DM and a significant overall relationship between salivary glucose concentration and associated glycemia/HbA1c values, with the strength of the correlation increasing for higher glycemia/HbA1c values. These results support the potential of salivary glucose levels as a biomarker for type 2 DM, providing a less painful/invasive method for screening type 2 DM, as well as for monitoring blood glucose levels in large cohorts of DM patients. PMID:25025218

Serum Metabolomic Profiling in Acute Alcoholic Hepatitis Identifies Multiple Dysregulated Pathways

PubMed Central

Rachakonda, Vikrant; Gabbert, Charles; Raina, Amit; Bell, Lauren N.; Cooper, Sara; Malik, Shahid; Behari, Jaideep

2014-01-01

Background and Objectives While animal studies have implicated derangements of global energy homeostasis in the pathogenesis of acute alcoholic hepatitis (AAH), the relevance of these findings to the development of human AAH remains unclear. Using global, unbiased serum metabolomics analysis, we sought to characterize alterations in metabolic pathways associated with severe AAH and identify potential biomarkers for disease prognosis. Methods This prospective, case-control study design included 25 patients with severe AAH and 25 ambulatory patients with alcoholic cirrhosis. Serum samples were collected within 24 hours of the index clinical encounter. Global, unbiased metabolomics profiling was performed. Patients were followed for 180 days after enrollment to determine survival. Results Levels of 234 biochemicals were altered in subjects with severe AAH. Random-forest analysis, principal component analysis, and integrated hierarchical clustering methods demonstrated that metabolomics profiles separated the two cohorts with 100% accuracy. Severe AAH was associated with enhanced triglyceride lipolysis, impaired mitochondrial fatty acid beta oxidation, and upregulated omega oxidation. Low levels of multiple lysolipids and related metabolites suggested decreased plasma membrane remodeling in severe AAH. While most measured bile acids were increased in severe AAH, low deoxycholate and glycodeoxycholate levels indicated intestinal dysbiosis. Several changes in substrate utilization for energy homeostasis were identified in severe AAH, including increased glucose consumption by the pentose phosphate pathway, altered tricarboxylic acid (TCA) cycle activity, and enhanced peptide catabolism. Finally, altered levels of small molecules related to glutathione metabolism and antioxidant vitamin depletion were observed in patients with severe AAH. Univariable logistic regression revealed 15 metabolites associated with 180-day survival in severe AAH. Conclusion Severe AAH is characterized by a distinct metabolic phenotype spanning multiple pathways. Metabolomics profiling revealed a panel of biomarkers for disease prognosis, and future studies are planned to validate these findings in larger cohorts of patients with severe AAH. PMID:25461442

Policy Planning for Early Childhood Care and Education: 2000-2014

ERIC Educational Resources Information Center

Vargas-Barón, Emily

2016-01-01

This article is based on a background paper commissioned for the EFA Global Monitoring Report 2015, "Education for All 2000-2015: Achievements and Challenges." It presents an analysis of the global evolution of policy planning for early childhood care and education (ECCE) from before 2000 to 2014, data regarding the national and regional…

The Effects of Intercultural Learning on English Learning Motivation among Students Studying Abroad

ERIC Educational Resources Information Center

Tsai, Yau

2012-01-01

Background: While English is becoming as a tool of communication and interaction with people from different countries in the global society of the twenty-first century due to the trend toward globalization and internationalization, those who study abroad and immerse themselves in the host culture may experience intercultural learning naturally…

Perception of Shapes Targeting Local and Global Processes in Autism Spectrum Disorders

ERIC Educational Resources Information Center

Grinter, Emma J.; Maybery, Murray T.; Pellicano, Elizabeth; Badcock, Johanna C.; Badcock, David R.

2010-01-01

Background: Several researchers have found evidence for impaired global processing in the dorsal visual stream in individuals with autism spectrum disorders (ASDs). However, support for a similar pattern of visual processing in the ventral visual stream is less consistent. Critical to resolving the inconsistency is the assessment of local and…

Global Isomorphism and Governance Reform in Chinese Higher Education

ERIC Educational Resources Information Center

Cai, Yuzhuo

2010-01-01

In the past three decades, higher education reforms have taken place almost everywhere in the world, and governance or the way that higher education is or should be coordinated has become a global topic. The governance reform in Chinese higher education emerged against such a background. The current studies on Chinese higher education reforms…

Translation on Its Own Terms? Toward Education for Global Culture

ERIC Educational Resources Information Center

Saito, Naoko

2017-01-01

Roger Ames' keynote provides a powerful orientation for thinking about translation. Against the background of his outstanding research career as a mediator between East and West, he offers a clear vision of global cultivation through what he calls "cultural translation." Encouraging and insightful as Ames' account of translation is, and…

Moving the Borders: Multiculturalism and Global Citizenship in the German Social Studies Classroom

ERIC Educational Resources Information Center

Ortloff, Debora Hinderliter

2011-01-01

Background: In many countries, working towards a truly inclusive national citizenship means deconstructing hegemonic structures that are deeply entrenched. Moving outside of the borders toward a global citizenship hints at giving up on what has been a long road toward multicultural citizenship. A balance between including and empowering diverse…

The Global Classroom: An Annotated Bibliography for Elementary and Secondary Teachers.

ERIC Educational Resources Information Center

Minnesota Univ., Minneapolis. Coll. of Education.

This bibliography identifies over 150 resources that help students understand the interdependent nature of the world. It is designed to be an overview rather than a comprehensive bibliography. Section I reviews books and articles that provide a basis for understanding the development of global education, its background, and basic definitions in…

Global Spent Fuel Logistics Systems Study (GSFLS). Volume 2A. GSFLS visit findings (appendix). Interim report

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1978-01-31

This appendix is a part of the interim report documentation for the Global Spent Fuel Logistics System (GSFLS) study. This appendix provides the legal/regulatory reference material, supportive of Volume 2 - GSFLS Visit Finding and Evaluations; and certain background material on British Nuclear Fuel Limited (BNFL).

Projected loss of a salamander diversity hotspot as a consequence of projected global climate change

Treesearch

Joseph R. Milanovich; William E. Peterman; Nathan P. Nibbelink; John C. Maerz

2010-01-01

Background: Significant shifts in climate are considered a threat to plants and animals with significant physiological limitations and limited dispersal abilities. The southern Appalachian Mountains are a global hotspot for plethodontid salamander diversity. Plethodontids are lungless ectotherms, so their ecology is strongly governed by temperature and precipitation....

Estimating North American background ozone in U.S. surface air with two independent global models: Variability, uncertainties, and recommendations

EPA Science Inventory

Accurate estimates for North American background (NAB) ozone (O3) in surface air over the United States are needed for setting and implementing an attainable national O3 standard. These estimates rely on simulations with atmospheric chemistry-transport models that set North Amer...

Environmental background values of trace elements in sediments from the Jiaozhou Bay catchment, Qingdao, China.

PubMed

Xu, Fangjian; Liu, Zhaoqing; Yuan, Shengqiang; Zhang, Xilin; Sun, Zhilei; Xu, Feng; Jiang, Zuzhou; Li, Anchun; Yin, Xuebo

2017-08-15

Selected trace elements (As, Cr, Zn, Cu, Cd, Co, Pb and Ni) in 76 surface sediment samples collected from the rivers and the intertidal zone of Jiaozhou Bay (JZB) were evaluated to assess their environmental background values in the JZB catchment. Overall, the sediment quality in the area meets the China Marine Sediment Quality criteria. The background values (ranges) of the elements As, Cr, Zn, Cu, Cd, Co, Pb and Ni were, respectively, 8.28 (4.10-12.46), 67.96 (38.40-97.52), 56.80 (16.42-196.51), 19.13 (5.71-64.06), 0.10 (0.02-0.42), 6.51 (2.08-20.40), 17.97 (12.26-55.84) and 20.69 (10.43-30.95)mg/kg. The background values of most of the trace elements were lower than those in Chinese soil, the upper continental crust, global shales and global preindustrial sediments. The results may assist in defining future coastal and river management measures specifically targeted at monitoring trace element contamination in the JZB catchment. Copyright © 2017 Elsevier Ltd. All rights reserved.

Instability in strongly magnetized accretion discs: a global perspective

NASA Astrophysics Data System (ADS)

Das, Upasana; Begelman, Mitchell C.; Lesur, Geoffroy

2018-01-01

We examine the properties of strongly magnetized accretion discs in a global framework, with particular focus on the evolution of magnetohydrodynamic instabilities such as the magnetorotational instability (MRI). Work by Pessah & Psaltis showed that MRI is stabilized beyond a critical toroidal field in compressible, differentially rotating flows and, also, reported the appearance of two new instabilities beyond this field. Their results stemmed from considering geometric curvature effects due to the suprathermal background toroidal field, which had been previously ignored in weak-field studies. However, their calculations were performed under the local approximation, which poses the danger of introducing spurious behaviour due to the introduction of global geometric terms in an otherwise local framework. In order to avoid this, we perform a global eigenvalue analysis of the linearized MHD equations in cylindrical geometry. We confirm that MRI indeed tends to be highly suppressed when the background toroidal field attains the Pessah-Psaltis limit. We also observe the appearance of two new instabilities that emerge in the presence of highly suprathermal toroidal fields. These results were additionally verified using numerical simulations in PLUTO. There are, however, certain differences between the the local and global results, especially in the vertical wavenumber occupancies of the various instabilities, which we discuss in detail. We also study the global eigenfunctions of the most unstable modes in the suprathermal regime, which are inaccessible in the local analysis. Overall, our findings emphasize the necessity of a global treatment for accurately modelling strongly magnetized accretion discs.

Reduced modeling of the magnetorotational instability

NASA Astrophysics Data System (ADS)

Jamroz, Ben F.

2009-06-01

Accretion describes the process by which matter in an astrophysical disk falls onto a central massive object. Accretion disks are present in many astrophysical situations including binary star systems, young stellar objects, and near black holes at the center of galaxies. Measurements from observations of these disks have shown that viscous processes are unable to transport the necessary levels of angular momentum needed for accretion. Therefore, accretion requires an efficient mechanism of angular momentum transport. Mixing by turbulent processes greatly enhances the level of angular momentum transport in a turbulent fluid. Thus, the generation of turbulence in these disks may provide the mechanism needed for accretion. A classical result of hydrodynamic theory is that typical accretion disks are hydrodynamically stable to shear instabilities, since the specific angular momentum increases outwards. Other processes of generating hydrodynamic turbulence (barotropic instability, baroclinic instability, sound wave, shock waves, finite amplitude instabilities) may be present in these disks, however, none of these mechanisms has been shown to produce the level of angular momentum transport needed for accretion. Hydrodynamical turbulence does not produce enough angular momentum transport to produce the level of accretion observed in astrophysical accretion disks. The leading candidate for the source of turbulence leading to the transport of angular momentum is the magnetorotational instability, a linear axisymmetric instability of electrically conducting fluid in the presence of an imposed magnetic field and shear (or differential rotation). This instability is an efficient mechanism of angular momentum transport generating the level of transport needed for accretion. The level of effective angular momentum transport is determined by the saturated state of sustained turbulence generated by the instability. The mechanism of nonlinear saturation of this instability is not well understood. Many recent numerical investigations of this problem are performed in a local domain, where the global cylindrical background state is projected onto a local Cartesian domain. The resulting system is then numerically modeled within a "shearing box" framework to obtain estimates of angular momentum transport and therefore accretion. However, the simplified geometry of the local domain, and the projection of global quantities leads to a model where the instability is able to grow unboundedly. Utilizing disparate characteristic scales, this thesis presents a reduced asymptotic model for the magnetorotational instability that allows a large scale feedback of local stresses (Reynolds, Maxwell and mixed) onto the projected background state. This system is investigated numerically to determine the impact of allowing this feedback on the saturated level of angular momentum transport.

Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

NASA Astrophysics Data System (ADS)

Kwon, H.; Kang, J.-S.; Jo, Y.; Kang, J. H.

2015-03-01

The Korea Institute of Atmospheric Prediction Systems (KIAPS) has been developing a new global numerical weather prediction model and an advanced data assimilation system. As part of the KIAPS package for observation processing (KPOP) system for data assimilation, preprocessing, and quality control modules for bending-angle measurements of global positioning system radio occultation (GPS-RO) data have been implemented and examined. The GPS-RO data processing system is composed of several steps for checking observation locations, missing values, physical values for Earth radius of curvature, and geoid undulation. An observation-minus-background check is implemented by use of a one-dimensional observational bending-angle operator, and tangent point drift is also considered in the quality control process. We have tested GPS-RO observations utilized by the Korean Meteorological Administration (KMA) within KPOP, based on both the KMA global model and the National Center for Atmospheric Research Community Atmosphere Model with Spectral Element dynamical core (CAM-SE) as a model background. Background fields from the CAM-SE model are incorporated for the preparation of assimilation experiments with the KIAPS local ensemble transform Kalman filter (LETKF) data assimilation system, which has been successfully implemented to a cubed-sphere model with unstructured quadrilateral meshes. As a result of data processing, the bending-angle departure statistics between observation and background show significant improvement. Also, the first experiment in assimilating GPS-RO bending angle from KPOP within KIAPS-LETKF shows encouraging results.

Radiological assessment for bauxite mining and alumina refining.

PubMed

O'Connor, Brian H; Donoghue, A Michael; Manning, Timothy J H; Chesson, Barry J

2013-01-01

Two international benchmarks assess whether the mining and processing of ores containing Naturally Occurring Radioactive Material (NORM) require management under radiological regulations set by local jurisdictions. First, the 1 Bq/g benchmark for radionuclide head of chain activity concentration determines whether materials may be excluded from radiological regulation. Second, processes may be exempted from radiological regulation where occupational above-background exposures for members of the workforce do not exceed 1 mSv/year. This is also the upper-limit of exposure prescribed for members of the public. Alcoa of Australia Limited (Alcoa) has undertaken radiological evaluations of the mining and processing of bauxite from the Darling Range of Western Australia since the 1980s. Short-term monitoring projects have demonstrated that above-background exposures for workers do not exceed 1 mSv/year. A whole-of-year evaluation of above-background, occupational radiological doses for bauxite mining, alumina refining and residue operations was conducted during 2008/2009 as part of the Alcoa NORM Quality Assurance System (NQAS). The NQAS has been guided by publications from the International Commission on Radiological Protection (ICRP), the International Atomic Energy Agency (IAEA) and the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA). The NQAS has been developed specifically in response to implementation of the Australian National Directory on Radiation Protection (NDRP). Positional monitoring was undertaken to increase the accuracy of natural background levels required for correction of occupational exposures. This is important in view of the small increments in exposure that occur in bauxite mining, alumina refining and residue operations relative to natural background. Positional monitoring was also undertaken to assess the potential for exposure in operating locations. Personal monitoring was undertaken to characterise exposures in Similar Exposure Groups (SEGs). The monitoring was undertaken over 12 months, to provide annual average assessments of above-background doses, thereby reducing temporal variations, especially for radon exposures. The monitoring program concentrated on gamma and radon exposures, rather than gross alpha exposures, as past studies have shown that gross alpha exposures from inhalable dust for most of the workforce are small in comparison to combined gamma and radon exposures. The natural background determinations were consistent with data in the literature for localities near Alcoa's mining, refining and residue operations in Western Australia, and also with UNSCEAR global data. Within the mining operations, there was further consistency between the above-background dose estimates and the local geochemistry, with slight elevation of dose levels in mining pits. Conservative estimates of above-background levels for the workforce have been made using an assumption of 100% occupancy (1920 hours per year) for the SEGs considered. Total incremental composite doses for individuals were clearly less than 1.0 mSv/year when gamma, radon progeny and gross alpha exposures were considered. This is despite the activity concentration of some materials being slightly higher than the benchmark of 1 Bq/g. The results are consistent with previous monitoring and demonstrate compliance with the 1 mSv/year exemption level within mining, refining and residue operations. These results will be of value to bauxite mines and alumina refineries elsewhere in the world.

Understanding the rapid growth of background concentrations of methane in 2007

NASA Astrophysics Data System (ADS)

Witham, C. S.; Manning, A. J.; O'Doherty, S.; Simmonds, P. G.

2009-04-01

The growth of background levels of atmospheric methane showed a marked increase in both hemispheres in 2007. This paper looks at the data from a range of observation stations that monitor methane at high frequency, including Barrow (Alaska), Ragged Point (Barbados), Trinidad Head (California), Cape Grim (Australia), Cape Matatula (Samoa), Gosan (South Korea) and Mace Head (Ireland), to try to understand the likely causes for this sudden rise. At each station the recent history of the air arriving at each station is considered using the NAME model. NAME (Numerical Atmospheric-dispersion Modelling Environment) is a Lagrangian atmospheric dispersion model that uses 3D meteorology from the UK Met Office numerical weather prediction model. High temporal resolution and high precision measurements of a wide range of trace gases in ambient air are available from the instrumentation at the AGAGE (Advanced Global Atmospheric Gases Experiment), NOAA and Korean measurement stations. The locations of these stations span both hemispheres and therefore allow global changes to be monitored. In this work, we are primarily interested in the measurements of methane and carbon monoxide. Baseline concentrations of methane and carbon monoxide have been determined for both the Northern and Southern Hemispheres using NAME and statistical post-processing of the observations at each measurement station. For this application, NAME is run backwards in time for ten days for each 3-hour interval for the years of specific interest 2006-2008 inclusive, releasing thousands of model particles at each observing site. A map is then produced estimating all of the surface (0-100m) contributions within ten days of travel arriving at each site during each interval. The resulting matrix describes the dilution in concentration that occurs from a unit release from each grid as it travels to the measurement site. By identifying regions where air is expected to be unpolluted, baseline periods can be determined. Statistical filtering of the remaining data allows a daily baseline concentration to be estimated for each station. These baselines are used to generate a time series of "polluted" (above baseline) observations at each station. Analysis of these baseline and polluted levels over time allows identification of changes in growth rates and seasonal cycles for each species, site and hemisphere. In 2007, the growth rate of background levels of methane was significantly elevated at all AGAGE stations (Rigby et al., 2008). The increase in growth rate appears to have occurred nearly simultaneously in both hemispheres. This raises the possibility of a common global cause for the change and a previously postulated explanation is that it could be due to a change in the global OH sink. However, OH is the main atmospheric sink for carbon monoxide and we see no coincident change in the growth rate of this species. In fact, there has been negligible growth in carbon monoxide at Mace Head since the end of 2005. The magnitude of the observed change also varied with location and was highest in the high Arctic. Another postulated theory was enhanced emissions in the high Arctic, but in isolation this would fail to explain a change that was seen so rapidly across the globe, particularly in the Southern Hemisphere. We present detailed analyses of the origin of the air reaching each site during the start of the period of growth. For each point identified as baseline, we consider the recent history of the air to determine whether there was a significant change in the source area of measured methane during this period and discern the geographical area responsible for the rise in background levels. The results provide useful insight to the key questions as to whether all sites were affected simultaneously (or whether there was a gradual change between different sites over a few months) and why the magnitude of the change may have been different at different latitudes. Reference: Rigby, M., et al. (2008), Renewed growth of atmospheric methane, Geophys. Res. Lett., 35, L22805, doi:10.1029/2008GL036037.

Estimating the development assistance for health provided to faith-based organizations, 1990-2013.

PubMed

Haakenstad, Annie; Johnson, Elizabeth; Graves, Casey; Olivier, Jill; Duff, Jean; Dieleman, Joseph L

2015-01-01

Faith-based organizations (FBOs) have been active in the health sector for decades. Recently, the role of FBOs in global health has been of increased interest. However, little is known about the magnitude and trends in development assistance for health (DAH) channeled through these organizations. Data were collected from the 21 most recent editions of the Report of Voluntary Agencies. These reports provide information on the revenue and expenditure of organizations. Project-level data were also collected and reviewed from the Bill & Melinda Gates Foundation and the Global Fund to Fight AIDS, Tuberculosis and Malaria. More than 1,900 non-governmental organizations received funds from at least one of these three organizations. Background information on these organizations was examined by two independent reviewers to identify the amount of funding channeled through FBOs. In 2013, total spending by the FBOs identified in the VolAg amounted to US$1.53 billion. In 1990, FB0s spent 34.1% of total DAH provided by private voluntary organizations reported in the VolAg. In 2013, FBOs expended 31.0%. Funds provided by the Global Fund to FBOs have grown since 2002, amounting to $80.9 million in 2011, or 16.7% of the Global Fund's contributions to NGOs. In 2011, the Gates Foundation's contributions to FBOs amounted to $7.1 million, or 1.1% of the total provided to NGOs. Development assistance partners exhibit a range of preferences with respect to the amount of funds provided to FBOs. Overall, estimates show that FBOS have maintained a substantial and consistent share over time, in line with overall spending in global health on NGOs. These estimates provide the foundation for further research on the spending trends and effectiveness of FBOs in global health.

Low Diversity Cryptococcus neoformans Variety grubii Multilocus Sequence Types from Thailand Are Consistent with an Ancestral African Origin

PubMed Central

Simwami, Sitali P.; Khayhan, Kantarawee; Henk, Daniel A.; Aanensen, David M.; Boekhout, Teun; Hagen, Ferry; Brouwer, Annemarie E.; Harrison, Thomas S.; Donnelly, Christl A.; Fisher, Matthew C.

2011-01-01

The global burden of HIV-associated cryptococcal meningitis is estimated at nearly one million cases per year, causing up to a third of all AIDS-related deaths. Molecular epidemiology constitutes the main methodology for understanding the factors underpinning the emergence of this understudied, yet increasingly important, group of pathogenic fungi. Cryptococcus species are notable in the degree that virulence differs amongst lineages, and highly-virulent emerging lineages are changing patterns of human disease both temporally and spatially. Cryptococcus neoformans variety grubii (Cng, serotype A) constitutes the most ubiquitous cause of cryptococcal meningitis worldwide, however patterns of molecular diversity are understudied across some regions experiencing significant burdens of disease. We compared 183 clinical and environmental isolates of Cng from one such region, Thailand, Southeast Asia, against a global MLST database of 77 Cng isolates. Population genetic analyses showed that Thailand isolates from 11 provinces were highly homogenous, consisting of the same genetic background (globally known as VNI) and exhibiting only ten nearly identical sequence types (STs), with three (STs 44, 45 and 46) dominating our sample. This population contains significantly less diversity when compared against the global population of Cng, specifically Africa. Genetic diversity in Cng was significantly subdivided at the continental level with nearly half (47%) of the global STs unique to a genetically diverse and recombining population in Botswana. These patterns of diversity, when combined with evidence from haplotypic networks and coalescent analyses of global populations, are highly suggestive of an expansion of the Cng VNI clade out of Africa, leading to a limited number of genotypes founding the Asian populations. Divergence time testing estimates the time to the most common ancestor between the African and Asian populations to be 6,920 years ago (95% HPD 122.96 - 27,177.76). Further high-density sampling of global Cng STs is now necessary to resolve the temporal sequence underlying the global emergence of this human pathogen. PMID:21573144

Poverty-related and neglected diseases – an economic and epidemiological analysis of poverty relatedness and neglect in research and development

PubMed Central

von Philipsborn, Peter; Steinbeis, Fridolin; Bender, Max E.; Regmi, Sadie; Tinnemann, Peter

2015-01-01

Background Economic growth in low- and middle-income countries (LMIC) has raised interest in how disease burden patterns are related to economic development. Meanwhile, poverty-related diseases are considered to be neglected in terms of research and development (R&D). Objectives Developing intuitive and meaningful metrics to measure how different diseases are related to poverty and neglected in the current R&D system. Design We measured how diseases are related to economic development with the income relation factor (IRF), defined by the ratio of disability-adjusted life-years (DALYs) per 100,000 inhabitants in LMIC versus that in high-income countries. We calculated the IRF for 291 diseases and injuries and 67 risk factors included in the Global Burden of Disease Study 2010. We measured neglect in R&D with the neglect factor (NF), defined by the ratio of disease burden in DALYs (as percentage of the total global disease burden) and R&D expenditure (as percentage of total global health-related R&D expenditure) for 26 diseases. Results The disease burden varies considerably with the level of economic development, shown by the IRF (median: 1.38; interquartile range (IQR): 0.79–6.3). Comparison of IRFs from 1990 to 2010 highlights general patterns of the global epidemiological transition. The 26 poverty-related diseases included in our analysis of neglect in R&D are responsible for 13.8% of the global disease burden, but receive only 1.34% of global health-related R&D expenditure. Within this group, the NF varies considerably (median: 19; IQR: 6–52). Conclusions The IRF is an intuitive and meaningful metric to highlight shifts in global disease burden patterns. A large shortfall exists in global R&D spending for poverty-related and neglected diseases, with strong variations between diseases. PMID:25623607

Low diversity Cryptococcus neoformans variety grubii multilocus sequence types from Thailand are consistent with an ancestral African origin.

PubMed

Simwami, Sitali P; Khayhan, Kantarawee; Henk, Daniel A; Aanensen, David M; Boekhout, Teun; Hagen, Ferry; Brouwer, Annemarie E; Harrison, Thomas S; Donnelly, Christl A; Fisher, Matthew C

2011-04-01

The global burden of HIV-associated cryptococcal meningitis is estimated at nearly one million cases per year, causing up to a third of all AIDS-related deaths. Molecular epidemiology constitutes the main methodology for understanding the factors underpinning the emergence of this understudied, yet increasingly important, group of pathogenic fungi. Cryptococcus species are notable in the degree that virulence differs amongst lineages, and highly-virulent emerging lineages are changing patterns of human disease both temporally and spatially. Cryptococcus neoformans variety grubii (Cng, serotype A) constitutes the most ubiquitous cause of cryptococcal meningitis worldwide, however patterns of molecular diversity are understudied across some regions experiencing significant burdens of disease. We compared 183 clinical and environmental isolates of Cng from one such region, Thailand, Southeast Asia, against a global MLST database of 77 Cng isolates. Population genetic analyses showed that Thailand isolates from 11 provinces were highly homogenous, consisting of the same genetic background (globally known as VNI) and exhibiting only ten nearly identical sequence types (STs), with three (STs 44, 45 and 46) dominating our sample. This population contains significantly less diversity when compared against the global population of Cng, specifically Africa. Genetic diversity in Cng was significantly subdivided at the continental level with nearly half (47%) of the global STs unique to a genetically diverse and recombining population in Botswana. These patterns of diversity, when combined with evidence from haplotypic networks and coalescent analyses of global populations, are highly suggestive of an expansion of the Cng VNI clade out of Africa, leading to a limited number of genotypes founding the Asian populations. Divergence time testing estimates the time to the most common ancestor between the African and Asian populations to be 6,920 years ago (95% HPD 122.96 - 27,177.76). Further high-density sampling of global Cng STs is now necessary to resolve the temporal sequence underlying the global emergence of this human pathogen.

Global Estimates of Ambient Fine Particulate Matter Concentrations from Satellite-Based Aerosol Optical Depth: Development and Application

PubMed Central

van Donkelaar, Aaron; Martin, Randall V.; Brauer, Michael; Kahn, Ralph; Levy, Robert; Verduzco, Carolyn; Villeneuve, Paul J.

2010-01-01

Background Epidemiologic and health impact studies of fine particulate matter with diameter < 2.5 μm (PM2.5) are limited by the lack of monitoring data, especially in developing countries. Satellite observations offer valuable global information about PM2.5 concentrations. Objective In this study, we developed a technique for estimating surface PM2.5 concentrations from satellite observations. Methods We mapped global ground-level PM2.5 concentrations using total column aerosol optical depth (AOD) from the MODIS (Moderate Resolution Imaging Spectroradiometer) and MISR (Multiangle Imaging Spectroradiometer) satellite instruments and coincident aerosol vertical profiles from the GEOS-Chem global chemical transport model. Results We determined that global estimates of long-term average (1 January 2001 to 31 December 2006) PM2.5 concentrations at approximately 10 km × 10 km resolution indicate a global population-weighted geometric mean PM2.5 concentration of 20 μg/m3. The World Health Organization Air Quality PM2.5 Interim Target-1 (35 μg/m3 annual average) is exceeded over central and eastern Asia for 38% and for 50% of the population, respectively. Annual mean PM2.5 concentrations exceed 80 μg/m3 over eastern China. Our evaluation of the satellite-derived estimate with ground-based in situ measurements indicates significant spatial agreement with North American measurements (r = 0.77; slope = 1.07; n = 1057) and with noncoincident measurements elsewhere (r = 0.83; slope = 0.86; n = 244). The 1 SD of uncertainty in the satellite-derived PM2.5 is 25%, which is inferred from the AOD retrieval and from aerosol vertical profile errors and sampling. The global population-weighted mean uncertainty is 6.7 μg/m3. Conclusions Satellite-derived total-column AOD, when combined with a chemical transport model, provides estimates of global long-term average PM2.5 concentrations. PMID:20519161

Targeting factors for change: contraceptive counselling and care of female adolescents.

PubMed

Bitzer, Johannes; Abalos, Virginia; Apter, Dan; Martin, Ricardo; Black, Amanda

2016-12-01

Sexual and reproductive health care should empower and enable all individuals to have a sex life that is as safe and pleasurable as possible. Achievement of this goal for adolescents is often impeded by regional and sociocultural barriers. To review global barriers to provision of effective counselling and care of adolescents seeking advice on contraception and sexual and reproductive health and identify elements of best practice that can be adapted to meet their needs at regional level. Experts with clinical experience and a scholarly background in the provision of contraceptive services to adolescents participated in a stepwise process of literature review and discussion according to the agreed objectives. The Global CARE (Contraception: Access, Resources, Education) group identified barriers to the access, availability and acceptance of contraception by adolescents, not only at the political and sociocultural level but also within health care practice. The group collected and summarized successful local strategies and tools suitable for adaptation in other regions. Elements of best practice for providing contraception regardless of setting or regional constraints, including required skills, knowledge, and attitudes, were also proposed. Sharing of evidence-based best practice in delivering contraceptive services, improvements in health care provider education, and sharing of experience between countries will hopefully help to overcome the barriers to appropriate and effective counselling and care of adolescents.

Background noise spectra of global seismic stations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wada, M.M.; Claassen, J.P.

1996-08-01

Over an extended period of time station noise spectra were collected from various sources for use in estimating the detection and location performance of global networks of seismic stations. As the database of noise spectra enlarged and duplicate entries became available, an effort was mounted to more carefully select station noise spectra while discarding others. This report discusses the methodology and criteria by which the noise spectra were selected. It also identifies and illustrates the station noise spectra which survived the selection process and which currently contribute to the modeling efforts. The resulting catalog of noise statistics not only benefitsmore » those who model network performance but also those who wish to select stations on the basis of their noise level as may occur in designing networks or in selecting seismological data for analysis on the basis of station noise level. In view of the various ways by which station noise were estimated by the different contributors, it is advisable that future efforts which predict network performance have available station noise data and spectral estimation methods which are compatible with the statistics underlying seismic noise. This appropriately requires (1) averaging noise over seasonal and/or diurnal cycles, (2) averaging noise over time intervals comparable to those employed by actual detectors, and (3) using logarithmic measures of the noise.« less

Living Liquid: Design and Evaluation of an Exploratory Visualization Tool for Museum Visitors.

PubMed

Ma, J; Liao, I; Ma, Kwan-Liu; Frazier, J

2012-12-01

Interactive visualizations can allow science museum visitors to explore new worlds by seeing and interacting with scientific data. However, designing interactive visualizations for informal learning environments, such as museums, presents several challenges. First, visualizations must engage visitors on a personal level. Second, visitors often lack the background to interpret visualizations of scientific data. Third, visitors have very limited time at individual exhibits in museums. This paper examines these design considerations through the iterative development and evaluation of an interactive exhibit as a visualization tool that gives museumgoers access to scientific data generated and used by researchers. The exhibit prototype, Living Liquid, encourages visitors to ask and answer their own questions while exploring the time-varying global distribution of simulated marine microbes using a touchscreen interface. Iterative development proceeded through three rounds of formative evaluations using think-aloud protocols and interviews, each round informing a key visualization design decision: (1) what to visualize to initiate inquiry, (2) how to link data at the microscopic scale to global patterns, and (3) how to include additional data that allows visitors to pursue their own questions. Data from visitor evaluations suggests that, when designing visualizations for public audiences, one should (1) avoid distracting visitors from data that they should explore, (2) incorporate background information into the visualization, (3) favor understandability over scientific accuracy, and (4) layer data accessibility to structure inquiry. Lessons learned from this case study add to our growing understanding of how to use visualizations to actively engage learners with scientific data.

MISR L3 Global Products

Atmospheric Science Data Center

2016-10-31

Global Products The MISR Level 3 Products are global or regional maps of select parameters from the Level 2 products and ... from multiple orbits are combined to make complete Level 3 global maps at daily (D), monthly (M), quarterly (Q), and yearly (Y) time ...

INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR INHIBITOR, AMG-479, IN CETUXIMAB-REFRACTORY HEAD AND NECK SQUAMOUS CELL CARCINOMA

PubMed Central

Pohlmann, Paula R.; Rothenberg, Mace L.; Burkey, Brian B.; Parker, Joel; Palka, Kevin; Aulino, Joseph; Puzanov, Igor; Murphy, Barbara

2011-01-01

Background Recurrent head and neck squamous cell carcinoma (HNSCC) remains a difficult cancer to treat. Here, we describe a patient with HNSCC who had complete response to methotrexate (MTX) after progressing on multiple cytotoxic agents, cetuximab, and AMG-479 (monoclonal antibody against insulin-like growth factor-1 receptor [IGF-1R]). Methods The clinical information was collected by a retrospective medical record review under an Institutional Review Board–approved protocol. From 4 tumors and 2 normal mucosal epithelia, global gene expression, and IGF-1R and dihydrofolate reductase (DHFR) protein levels were determined. Results Effective target inhibition in the tumor was confirmed by the decreased protein levels of total and phospho-IGF-1R after treatment with AMG-479. Decreased level of DHFR and conversion of a gene expression profile associated with cetuximab-resistance to cetuximab-sensitivity were also observed. Conclusion This suggests that the combination of AMG- 479 and MTX or cetuximab may be a promising therapeutic approach in refractory HNSCC. PMID:20652976

Identifying and prioritizing industry-level competitiveness factors: evidence from pharmaceutical market

PubMed Central

2014-01-01

Background Pharmaceutical industry is knowledge-intensive and highly globalized, in both developed and developing countries. On the other hand, if companies want to survive, they should be able to compete well in both domestic and international markets. The main purpose of this paper is therefore to develop and prioritize key factors affecting companies’ competitiveness in pharmaceutical industry. Based on an extensive literature review, a valid and reliable questionnaire was designed, which was later filled up by participants from the industry. To prioritize the key factors, we used the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). Results The results revealed that human capital and macro-level policies were two key factors placed at the highest rank in respect of their effects on the competitiveness considering the industry-level in pharmaceutical area. Conclusion This study provides fundamental evidence for policymakers and managers in pharma context to enable them formulating better polices to be proactively competitive and responsive to the markets’ needs. PMID:24708770

Global sea level linked to global temperature

PubMed Central

Vermeer, Martin; Rahmstorf, Stefan

2009-01-01

We propose a simple relationship linking global sea-level variations on time scales of decades to centuries to global mean temperature. This relationship is tested on synthetic data from a global climate model for the past millennium and the next century. When applied to observed data of sea level and temperature for 1880–2000, and taking into account known anthropogenic hydrologic contributions to sea level, the correlation is >0.99, explaining 98% of the variance. For future global temperature scenarios of the Intergovernmental Panel on Climate Change's Fourth Assessment Report, the relationship projects a sea-level rise ranging from 75 to 190 cm for the period 1990–2100. PMID:19995972

Radiation Safety Issues in High Altitude Commercial Aircraft

NASA Technical Reports Server (NTRS)

Wilson, John W.; Cucinotta, Francis A.; Shinn, Judy L.

1995-01-01

The development of a global economy makes the outlook for high speed commercial intercontinental flight feasible, and the development of various configurations operating from 20 to 30 km have been proposed. In addition to the still unresolved issues relating to current commercial operations (12-16 km), the higher dose rates associated with the higher operating altitudes makes il imperative that the uncertainties in the atmospheric radiation environment and the associated health risks be re-examined. Atmospheric radiation associated with the galactic cosmic rays forms a background level which may, under some circumstances, exceed newly recommended allowable exposure limits proposed on the basis of recent evaluations of the A -bomb survivor data (due to increased risk coefficients). These larger risk coefficients, within the context of the methodology for estimating exposure limits, are resulting in exceedingly low estimated allowable exposure limits which may impact even present day flight operations and was the reason for the CEC workshop in Luxembourg (1990). At higher operating altitudes, solar particles events can produce exposures many orders of magnitude above background levels and pose significant health risks to the most sensitive individuals (such as during pregnancy). In this case the appropriate quality factors are undefined, and some evidence exists which indicates that the quality factor for stochastic effects is a substantial underestimate.

Extent of Integration of Priority Interventions into General Health Systems: A Case Study of Neglected Tropical Diseases Programme in the Western Region of Ghana

PubMed Central

Mensah, Ernest O.; Aikins, Moses K.; Gyapong, Margaret; Anto, Francis; Bockarie, Moses J.; Gyapong, John O.

2016-01-01

Background The global health system has a large arsenal of interventions, medical products and technologies to address current global health challenges. However, identifying the most effective and efficient strategies to deliver these resources to where they are most needed has been a challenge. Targeted and integrated interventions have been the main delivery strategies. However, the health system discourse increasingly favours integrated strategies in the context of functionally merging targeted interventions with multifunctional health care delivery systems with a focus on strengthening country health systems to deliver needed interventions. Neglected Tropical Diseases (NTD) have been identified to promote and perpetuate poverty hence there has been global effort to combat these diseases. The Neglected Tropical Diseases Programme (NTDP) in Ghana has a national programme team and office, however, it depends on the multifunctional health delivery system at the regional and district level to implement interventions. The NTDP seeks further health system integration to accelerate achievement of coverage targets. The study estimated the extent of integration of the NTDP at the national, regional and district levels to provide evidence to guide further integration. Methodology/Principal Findings The research design was a descriptive case study that interviewed key persons involved in the programme at the three levels of the health system as well as extensive document review. Integration was assessed on two planes—across health system functions–stewardship and governance, financing, planning, service delivery, monitoring and evaluation and demand generation; and across three administrative levels of the health system–national, regional and district. A composite measure of integration designated Cumulative Integration Index (CII) with a range of 0.00–1.00 was used to estimate extent of integration at the three levels of the health system. Service delivery was most integrated while financing and planning were least integrated. Extent of integration was partial at all levels of the health system with a CII of 0.48–0.68; however it was higher at the district compared to the national and regional levels. Conclusions/Significance To ensure further integration of the NTDP, planning and finance management activities must be decentralized to involve regional and district levels of the health system. The study provides an empirical measure of extent of integration and indicators to guide further integration. PMID:27203854

Overview of Global, Regional, and National Routine Vaccination Coverage Trends and Growth Patterns From 1980 to 2009: Implications for Vaccine-Preventable Disease Eradication and Elimination Initiatives

PubMed Central

Wallace, Aaron S.; Ryman, Tove K.; Dietz, Vance

2015-01-01

Background Review of the historical growth in annual vaccination coverage across countries and regions can better inform decision makers’ development of future goals and strategies to improve routine vaccination services. Methods Using the World Health Organization (WHO) and the United Nations Children's Fund estimates of annual national third dose of diphtheria-tetanus-pertussis–containing vaccine (DTP3) and third dose of polio vaccine (POL3) coverage for 1980–2009, we calculated the mean absolute annual rate of change in national DTP3 coverage among all countries (globally) and among countries within each WHO region, as well as the number of years taken by each region to reach specific regional coverage levels. Last, we assessed differences in mean absolute annual rate of change in DTP3 coverage, stratified by baseline level of DTP3 coverage. Results During the 1980s, global DTP3 coverage increased a mean of 5.3 percentage points/year. Annual rate of change decreased to 0.5 percentage points/year in the 1990s and then increased to 0.9 percentage points/year during the 2000s. Mean annual rate of change in coverage across all countries was highest (9.2 percentage points) when national coverage levels were 26%–30% and lowest (−0.9 percentage points) when national coverage levels were 96%–100%. Regional differences existed as both WHO South-East Asia Region and WHO African Region countries experienced mean negative DTP3 coverage growth at lower coverage levels (81%–85%) than other regions. The regions that have achieved 95% DTP3 coverage (Americas, Western Pacific, and European) took 25–29 years to reach that level from a level of 50% DTP3 coverage. POL3 coverage change trends were similar to described DTP3 coverage change trends. Conclusions Mean national coverage growth patterns across all regions are nonlinear as coverage levels increase. Saturation points of mean 0 percentage-point growth in annual coverage varies by region and require further investigation. The achievement of >90% routine coverage is observed to take decades, which has implications for disease eradication and elimination initiatives. PMID:25316875

Conceptual framework to ensure water security in Ukraine

NASA Astrophysics Data System (ADS)

Gadzalo, Yaroslav; Romashchenko, Mykhailo; Yatsiuk, Mykhailo

2018-02-01

As a result of global climate change against the background of natural water supply deterioration and river water content reductions, nowadays Ukraine is facing the problem of environmental degradation of river basins. In light of this, we suggest that achieving an acceptable level of water security in Ukraine should be defined as the strategic objective of national water policy. The state of national water security should be evaluated by its progress in certain sectors. The basic principles of the new water policy of Ukraine are supposed to be represented in Water Strategy of Ukraine. Integrated water management by the basin principle should serve as the main tool for achieving the objectives of water security.

Calculating background levels for ecological risk parameters in toxic harbor sediment

USGS Publications Warehouse

Leadon, C.J.; McDonnell, T.R.; Lear, J.; Barclift, D.

2007-01-01

Establishing background levels for biological parameters is necessary in assessing the ecological risks from harbor sediment contaminated with toxic chemicals. For chemicals in sediment, the term contaminated is defined as having concentrations above background and significant human health or ecological risk levels. For biological parameters, a site could be considered contaminated if levels of the parameter are either more or less than the background level, depending on the specific parameter. Biological parameters can include tissue chemical concentrations in ecological receptors, bioassay responses, bioaccumulation levels, and benthic community metrics. Chemical parameters can include sediment concentrations of a variety of potentially toxic chemicals. Indirectly, contaminated harbor sediment can impact shellfish, fish, birds, and marine mammals, and human populations. This paper summarizes the methods used to define background levels for chemical and biological parameters from a survey of ecological risk investigations of marine harbor sediment at California Navy bases. Background levels for regional biological indices used to quantify ecological risks for benthic communities are also described. Generally, background stations are positioned in relatively clean areas exhibiting the same physical and general chemical characteristics as nearby areas with contaminated harbor sediment. The number of background stations and the number of sample replicates per background station depend on the statistical design of the sediment ecological risk investigation, developed through the data quality objective (DQO) process. Biological data from the background stations can be compared to data from a contaminated site by using minimum or maximum background levels or comparative statistics. In Navy ecological risk assessments (ERA's), calculated background levels and appropriate ecological risk screening criteria are used to identify sampling stations and sites with contaminated sediments.

The Global Cardiovascular Risk Transition: Associations of Four Metabolic Risk Factors with Macroeconomic Variables in 1980 and 2008

PubMed Central

Danaei, Goodarz; Singh, Gitanjali M; Paciorek, Christopher J; Lin, John K; Cowan, Melanie J; Finucane, Mariel M; Farzadfar, Farshad; Stevens, Gretchen A; Riley, Leanne M; Lu, Yuan; Rao, Mayuree; Ezzati, Majid

2014-01-01

Background It is commonly assumed that globally CVD risk factors are associated with affluence and Westernization. We investigated the associations of body mass index (BMI), fasting plasma glucose (FPG), systolic blood pressure (SBP), and serum total cholesterol (TC) with national income, Western diet, and (for BMI) urbanization in 1980 and 2008. Methods and Results Country-level risk factor estimates for 199 countries between 1980 and 2008 were from a previous systematic analysis of population-based data. We analyzed the associations between risk factors and natural logarithm of per-capita GDP [Ln(GDP)], a measure of Western diet, and (for BMI) percent population living in urban areas. In 1980, there was a positive association between national income and population mean BMI, SBP, and TC. By 2008, the slope of the association between Ln(GDP) and SBP became negative for women and zero for men. TC was associated with national income and Western diet throughout the period. In 1980, BMI rose with per-capita GDP and then flattened at about Int$7000; by 2008, the relationship resembled an inverted-U for women, peaking at middle income levels. BMI had a positive relationship with percent urban population in both 1980 and 2008. FPG had weaker associations with these country macro characteristics, but was positively associated with BMI. Conclusions The changing associations of metabolic risk factors with macroeconomic variables indicate that there will be a global pandemic of hyperglycemia and diabetes, together with high blood pressure in low income countries, unless effective lifestyle, and pharmacological interventions are implemented. PMID:23481623

Air Contamination by Mercury, Emissions and Transformations-a Review.

PubMed

Gworek, Barbara; Dmuchowski, Wojciech; Baczewska, Aneta H; Brągoszewska, Paulina; Bemowska-Kałabun, Olga; Wrzosek-Jakubowska, Justyna

2017-01-01

The present and future air contamination by mercury is and will continue to be a serious risk for human health. This publication presents a review of the literature dealing with the issues related to air contamination by mercury and its transformations as well as its natural and anthropogenic emissions. The assessment of mercury emissions into the air poses serious methodological problems. It is particularly difficult to distinguish between natural and anthropogenic emissions and re-emissions from lands and oceans, including past emissions. At present, the largest emission sources include fuel combustion, mainly that of coal, and "artisanal and small-scale gold mining" (ASGM). The distinctly highest emissions can be found in South and South-East Asia, accounting for 45% of the global emissions. The emissions of natural origin and re-emissions are estimated at 45-66% of the global emissions, with the largest part of emissions originating in the oceans. Forecasts on the future emission levels are not unambiguous; however, most forecasts do not provide for reductions in emissions. Ninety-five percent of mercury occurring in the air is Hg 0 -GEM, and its residence time in the air is estimated at 6 to 18 months. The residence times of its Hg II -GOM and that in Hg p -TPM are estimated at hours and days. The highest mercury concentrations in the air can be found in the areas of mercury mines and those of ASGM. Since 1980 when it reached its maximum, the global background mercury concentration in the air has remained at a relatively constant level.

Infant and Young Child Feeding Behaviors among Working Mothers in India: Implications for Global Health Policy and Practice

PubMed Central

Kumar, Vinay; Arora, Gunjan; Midha, Ish Kumar; Gupta, Yogender Pal

2015-01-01

Background: The National Guidelines on Infant and Young Child Feeding introduced in 2006 recommended the initiation of breastfeeding immediately after birth, preferably within one hour; exclusive breastfeeding for the first six months; appropriate and adequate complementary feeding from six months of age while continuing breastfeeding; and continued breastfeeding up to the age of two years or beyond. Working women in India constitute a dominant and expanding pool of mothers. There is paucity of research focused on feeding behavior within this group. Method: One hundred and fifty working women answered a structured questionnaire about their demographics, birth history, levels of awareness and practice of feeding guidelines, and perceptions about breastfeeding and counseling. Data analysis was carried out using Microsoft Excel and the Statistical Package for the Social Sciences. Results: Majority of participants belonged to 21-39 years age group, had nuclear families, received college education, and delivered in institutional setups. Gaps were observed between the mother’s levels of awareness and practice for different tenets of national guidelines. Higher education, longer maternity leave, higher income, and utilization of counseling services facilitated adoption of optimal feeding behavior. Most women perceived breast milk to be superior to any alternative and favored provision of counseling during last trimester. Conclusions and Global Health Implications: Counseling women on optimal feeding behavior is a potential intervention to convert its awareness into actual practice. The lessons learned from this study can help refine both national and global Mother and Child Health policies and programs. PMID:27621981

Alternative Approaches for Educating Future Global Marketing Professionals: A Comparison of Foreign Study and Research-Intensive Marketing Programs

ERIC Educational Resources Information Center

Kaufman, Peter A.; Melton, Horace L.; Varner, Iris I.; Hoelscher, Mark; Schmidt, Klaus; Spaulding, Aslihan D.

2011-01-01

Using an experiential learning model as a conceptual background, this article discusses characteristics and learning objectives for well-known foreign study programs such as study tours, study abroad, and internships and compares them with a less common overseas program called the "Global Marketing Program" (GMP). GMP involves…

The OECD as Pivot of the Emerging Global Educational Accountability Regime: How Accountable Are the Accountants?

ERIC Educational Resources Information Center

Meyer, Heinz-Dieter

2014-01-01

Background/Context: PISA has catapulted the OECD- an organization whose mission is the global growth of market economies-to a central role in international education policy making, rivaling and sometimes outdoing the various national governments in influence. While claiming scientific evidence as the basis for the accountability regime it…

Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues

DTIC Science & Technology

2014-08-26

13 The FALCON Study...that would mate a rocket booster with a hypersonic glide vehicle. Congress has generally supported the rationale for the PGS mission, but it has...General: Precise Long-Range Missiles may Enable Big Nuclear Cuts,” Inside the Pentagon, April 28, 2005. Conventional Prompt Global Strike and Long-Range

Conventional Prompt Global Strike and Long-Range Ballistic Missiles: Background and Issues

DTIC Science & Technology

2015-02-06

Air Force Programs ................................................................................................................. 13 The FALCON ...glide technologies that would mate a rocket booster with a hypersonic glide vehicle. Congress has generally supported the rationale for the PGS mission...M., “U.S. General: Precise Long-Range Missiles may Enable Big Nuclear Cuts,” Inside the Pentagon, April 28, 2005. Conventional Prompt Global Strike

Teacher Education, the Global Financial Crisis, Frogs and Bicycles

ERIC Educational Resources Information Center

Ling, Lorraine

2012-01-01

Background: The extent to which the global financial crisis (GFC) has impacted upon teacher education in universities in Australia is potentially, like most other aspects of teacher education, a contested area. Purpose, aims/questions: The aim of this article is to examine the impact the GFC along with other funding constraints, has had on teacher…

From Rhetoric to Reality: Planning and Conducting Collaborations for International Research in the Global South

ERIC Educational Resources Information Center

Lombe, Margaret; Newransky, Chrisann; Crea, Tom; Stout, Anna

2013-01-01

International collaboration in social work research, particularly research in the global south, presents unique opportunities for the personal and professional development of researchers and students alike. Yet data to help direct the process are limited. Using a research project recently carried out in Ghana as background, the authors present…

The Global Youth Media Council: Young People Speaking and Learning about Media Reform

ERIC Educational Resources Information Center

Dezuanni, Michael Luigi; Miles, Prue

2011-01-01

The 5th World Summit on Media for Children and Youth held in Karlstad, Sweden in June 2010 provided a unique media literacy experience for approximately thirty young people from diverse backgrounds through participation in the Global Youth Media Council. This article focuses on the Summit's aim to give young people a "voice" through…

"What Price Respect"--Exploring the Notion of Respect in a 21st Century Global Learning Environment

ERIC Educational Resources Information Center

Wilson, Doirean

2010-01-01

This paper evaluates the meaning of respect in a 21st century global learning environment, with a view to exploring the implications for promoting harmonious working relationships among students of culturally diverse ethnic backgrounds in the classroom. Research conducted since 2005 that investigates the understanding, meaning and experience of…

Math and Science Gateways to California's Fastest Growing Careers

ERIC Educational Resources Information Center

EdSource, 2008

2008-01-01

Some students--and parents--think math and science are not too important for their future. As everyday life becomes more dependent on technology, most people will need a better background in math and science to succeed in today's global economy. To get high-paying jobs in some of California's fastest-growing occupations, a strong background in…

Exploring the Cross-Cultural Experiences of College Students with Diverse Backgrounds Performing International Service-Learning in Myanmar

ERIC Educational Resources Information Center

Liu, Ruo-lan; Lee, Hsin-hua

2011-01-01

Background: In view of the growing globalization, volunteer service organizations, local universities, colleges, and student groups have begun extending their service programs from Taiwan to other countries. This study employs a self-organized, self-funded group of university students participating in international service-learning as its subject,…

Electronic Warfare

DTIC Science & Technology

2012-02-08

EMOE is the background electromagnetic environment and the friendly, neutral, and adversarial electronic order of battle within the...X-RayELF VLF MF VHF SHFLF HF Radio Spectrum Visible Spectrum UHF EHF Gamma Ray Cosmic Ray The top bar shows how the electromagnetic spectrum is...effects of sunspots, lightning, and precipitation static. Essentially, the EME is the global EM background . Figure I-2. Electromagnetic Environment

Status of the implementation of the World Health Organization multimodal hand hygiene strategy in United States of America health care facilities

PubMed Central

Allegranzi, Benedetta; Conway, Laurie; Larson, Elaine; Pittet, Didier

2014-01-01

Background The World Health Organization (WHO) launched a multimodal strategy and campaign in 2009 to improve hand hygiene practices worldwide. Our objective was to evaluate the implementation of the strategy in United States health care facilities. Methods From July through December 2011, US facilities participating in the WHO global campaign were invited to complete the Hand Hygiene Self-Assessment Framework online, a validated tool based on the WHO multimodal strategy. Results Of 2,238 invited facilities, 168 participated in the survey (7.5%). A detailed analysis of 129, mainly nonteaching public facilities (80.6%), showed that most had an advanced or intermediate level of hand hygiene implementation progress (48.9% and 45.0%, respectively). The total Hand Hygiene Self-Assessment Framework score was 36 points higher for facilities with staffing levels of infection preventionists > 0.75/100 beds than for those with lower ratios (P = .01) and 41 points higher for facilities participating in hand hygiene campaigns (P = .002). Conclusion Despite the low response rate, the survey results are unique and allow interesting reflections. Whereas the level of progress of most participating facilities was encouraging, this may reflect reporting bias, ie, better hospitals more likely to report. However, even in respondents, further improvement can be achieved, in particular by embedding hand hygiene in a stronger institutional safety climate and optimizing staffing levels dedicated to infection prevention. These results should encourage the launch of a coordinated national campaign and higher participation in the WHO global campaign. PMID:24581011

Pushing boundaries-culture-sensitive care in oncology and palliative care: a qualitative study.

PubMed

Schrank, Beate; Rumpold, Tamara; Amering, Michaela; Masel, Eva Katharina; Watzke, Herbert; Schur, Sophie

2017-06-01

In increasingly globalized societies, patient-centered cancer care requires culture-sensitive approaches in order to ensure patients well-being. While migrant patients' needs are frequently reported in the literature, staff members' perception of work with migrant patients, associated challenges, or individual work approaches are largely unknown. This study addresses this research gap through qualitative exploration of experiences of multicultural health care professionals in supportive oncology and palliative care, working with patients from different cultural backgrounds. This study aims to understand staff experience of the impact of culture on cancer care. This study was conducted at the Medical University of Vienna, including staff from different settings of oncology and palliative care, in different professional positions, and with a range of individual migration backgrounds. Semistructured interviews were conducted with 21 staff members working with patients from different cultural backgrounds. Interviews explored views on the impact of culture on care were audio-taped, transcribed, and analyzed using a rigorous method of thematic analysis, enhanced with grounded theory techniques. Interviews revealed 4 key topics: culture-specific differences, assumed reasons for differences, consequences of multicultural care, and tools for culture-sensitive care. Strategies to better deal with migrant patients and their families were suggested to improve work satisfaction amongst staff. This study identifies relevant staff challenges in work with migrant patients. Concrete suggestions for improvement include measures on an organizational level, team level, and personal tools. The suggested measures are applicable to improve work satisfaction and culture-sensitive care not only in cancer care but also in other areas of medicine. Copyright © 2016 John Wiley & Sons, Ltd.

A variant of special relativity and long-distance astronomy.

PubMed

Segal, I E

1974-03-01

THE REDSHIFT, MICROWAVE BACKGROUND, AND OTHER OBSERVABLE ASTRONOMICAL FEATURES ARE DEDUCED FROM TWO THEORETICAL ASSUMPTIONS: (1) global space-time is a certain variant of Minkowski space, locally indistinguishable in causality and covariance features but globally admitting the full conformal group as symmetries although having a spherical space component; (2) the true energy operator corresponds to a certain generator of this group which is not globally scale-covariant, whereas laboratory frequency measurements are inevitably such and correspond to the conventional energy operator [unk]/i[unk]/[unk]t.

Towards resolving the complete fern tree of life.

PubMed

Lehtonen, Samuli

2011-01-01

In the past two decades, molecular systematic studies have revolutionized our understanding of the evolutionary history of ferns. The availability of large molecular data sets together with efficient computer algorithms, now enables us to reconstruct evolutionary histories with previously unseen completeness. Here, the most comprehensive fern phylogeny to date, representing over one-fifth of the extant global fern diversity, is inferred based on four plastid genes. Parsimony and maximum-likelihood analyses provided a mostly congruent results and in general supported the prevailing view on the higher-level fern systematics. At a deep phylogenetic level, the position of horsetails depended on the optimality criteria chosen, with horsetails positioned as the sister group either of Marattiopsida-Polypodiopsida clade or of the Polypodiopsida. The analyses demonstrate the power of using a 'supermatrix' approach to resolve large-scale phylogenies and reveal questionable taxonomies. These results provide a valuable background for future research on fern systematics, ecology, biogeography and other evolutionary studies.

Global Binary Continuity for Color Face Detection With Complex Background

NASA Astrophysics Data System (ADS)

Belavadi, Bhaskar; Mahendra Prashanth, K. V.; Joshi, Sujay S.; Suprathik, N.

2017-08-01

In this paper, we propose a method to detect human faces in color images, with complex background. The proposed algorithm makes use of basically two color space models, specifically HSV and YCgCr. The color segmented image is filled uniformly with a single color (binary) and then all unwanted discontinuous lines are removed to get the final image. Experimental results on Caltech database manifests that the purported model is able to accomplish far better segmentation for faces of varying orientations, skin color and background environment.

Global Energetics of Thirty-Eight Large Solar Eruptive Events

DTIC Science & Technology

2012-10-17

is the energy radiated in the narrow GOES band from 1 to 8 Å, obtained directly from background -subtracted data (Section 2.1). The second is the energy... background -subtracted fluxes over the duration of the flare, from the GOES start time (given by NOAA and listed in Table 1) to the time when the flux...had decreased to 10% of the peak value. The background that was subtracted was taken as the lowest flux in the hour or so before and/or after the flare

Segmental and global lordosis changes with two-level axial lumbar interbody fusion and posterior instrumentation

PubMed Central

Melgar, Miguel A; Tobler, William D; Ernst, Robert J; Raley, Thomas J; Anand, Neel; Miller, Larry E; Nasca, Richard J

2014-01-01

Background Loss of lumbar lordosis has been reported after lumbar interbody fusion surgery and may portend poor clinical and radiographic outcome. The objective of this research was to measure changes in segmental and global lumbar lordosis in patients treated with presacral axial L4-S1 interbody fusion and posterior instrumentation and to determine if these changes influenced patient outcomes. Methods We performed a retrospective, multi-center review of prospectively collected data in 58 consecutive patients with disabling lumbar pain and radiculopathy unresponsive to nonsurgical treatment who underwent L4-S1 interbody fusion with the AxiaLIF two-level system (Baxano Surgical, Raleigh NC). Main outcomes included back pain severity, Oswestry Disability Index (ODI), Odom's outcome criteria, and fusion status using flexion and extension radiographs and computed tomography scans. Segmental (L4-S1) and global (L1-S1) lumbar lordosis measurements were made using standing lateral radiographs. All patients were followed for at least 24 months (mean: 29 months, range 24-56 months). Results There was no bowel injury, vascular injury, deep infection, neurologic complication or implant failure. Mean back pain severity improved from 7.8±1.7 at baseline to 3.3±2.6 at 2 years (p < 0.001). Mean ODI scores improved from 60±15% at baseline to 34±27% at 2 years (p < 0.001). At final follow-up, 83% of patients were rated as good or excellent using Odom's criteria. Interbody fusion was observed in 111 (96%) of 116 treated interspaces. Maintenance of lordosis, defined as a change in Cobb angle ≤ 5°, was identified in 84% of patients at L4-S1 and 81% of patients at L1-S1. Patients with loss or gain in segmental or global lordosis experienced similar 2-year outcomes versus those with less than a 5° change. Conclusions/Clinical Relevance Two-level axial interbody fusion supplemented with posterior fixation does not alter segmental or global lordosis in most patients. Patients with postoperative change in lordosis greater than 5° have similarly favorable long-term clinical outcomes and fusion rates compared to patients with less than 5° lordosis change. PMID:25694920

Design of a perfluorocarbon tracer based monitoring network to support monitoring verification and accounting of sequestered CO2

NASA Astrophysics Data System (ADS)

Watson, T.; Sullivan, T.

2013-05-01

The levels of CO2 in the atmosphere have been growing since the beginning of the industrial revolution. The current level is 391 ppm. If there are no efforts to mitigate CO2 emissions, the levels will rise to 750 ppm by 2100. Geologic carbon sequestration is one strategy that may be used to begin to reduce emissions. Sequestration will not be effective unless reservoir leak rates are significantly less than 1%. There must be rigorous monitoring protocols in place to ensure sequestration projects meet regulatory and environmental goals. Monitoring for CO2 leakage directly is difficult because of the large background levels and variability of CO2 in the atmosphere. Using tracers to tag the sequestered CO2 can mitigate some of the difficulties of direct measurement but a tracer monitoring network and the levels of tagging need to be carefully designed. Simple diffusion and dispersion models are used to predict the surface and atmospheric concentrations that would be seen by a network monitoring a sequestration site. Levels of tracer necessary to detect leaks from 0.01 to 1% are presented and suggestions for effective monitoring and protection of global tracer utility are presented.

Regional Densification of a Global VTEC Model Based on B-Spline Representations

NASA Astrophysics Data System (ADS)

Erdogan, Eren; Schmidt, Michael; Dettmering, Denise; Goss, Andreas; Seitz, Florian; Börger, Klaus; Brandert, Sylvia; Görres, Barbara; Kersten, Wilhelm F.; Bothmer, Volker; Hinrichs, Johannes; Mrotzek, Niclas

2017-04-01

The project OPTIMAP is a joint initiative of the Bundeswehr GeoInformation Centre (BGIC), the German Space Situational Awareness Centre (GSSAC), the German Geodetic Research Institute of the Technical University Munich (DGFI-TUM) and the Institute for Astrophysics at the University of Göttingen (IAG). The main goal of the project is the development of an operational tool for ionospheric mapping and prediction (OPTIMAP). Two key features of the project are the combination of different satellite observation techniques (GNSS, satellite altimetry, radio occultations and DORIS) and the regional densification as a remedy against problems encountered with the inhomogeneous data distribution. Since the data from space-geoscientific mission which can be used for modeling ionospheric parameters, such as the Vertical Total Electron Content (VTEC) or the electron density, are distributed rather unevenly over the globe at different altitudes, appropriate modeling approaches have to be developed to handle this inhomogeneity. Our approach is based on a two-level strategy. To be more specific, in the first level we compute a global VTEC model with a moderate regional and spectral resolution which will be complemented in the second level by a regional model in a densification area. The latter is a region characterized by a dense data distribution to obtain a high spatial and spectral resolution VTEC product. Additionally, the global representation means a background model for the regional one to avoid edge effects at the boundaries of the densification area. The presented approach based on a global and a regional model part, i.e. the consideration of a regional densification is called the Two-Level VTEC Model (TLVM). The global VTEC model part is based on a series expansion in terms of polynomial B-Splines in latitude direction and trigonometric B-Splines in longitude direction. The additional regional model part is set up by a series expansion in terms of polynomial B-splines for both directions. The spectral resolution of both model parts is defined by the number of B-spline basis functions introduced for longitude and latitude directions related to appropriate coordinate systems. Furthermore, the TLVM has to be developed under the postulation that the global model part will be computed continuously in near real-time (NRT) and routinely predicted into the future by an algorithm based on deterministic and statistical forecast models. Thus, the additional regional densification model part, which will be computed also in NRT, but possibly only for a specified time duration, must be estimated independently from the global one. For that purpose a data separation procedure has to be developed in order to estimate the unknown series coefficients of both model parts independently. This procedure must also consider additional technique-dependent unknowns such as the Differential Code Biases (DCBs) within GNSS and intersystem biases. In this contribution we will present the concept to set up the TLVM including the data combination and the Kalman filtering procedure; first numerical results will be presented.

Nicorandil improves myocardial function by regulating plasma nitric oxide and endothelin-1 in coronary slow flow

PubMed Central

Chen, Xiuhua; Li, Shan; Huo, Xuezhen; Fu, Xiuxiu; Dong, Xiaonan

2015-01-01

Background Coronary slow flow (CSF) is a special coronary microvascular disorder. The pathogenesis and effective therapeutics of CSF remain unclear. This study aimed to evaluate the global and regional functions of the left ventricle (LV) and investigate the efficacy of nicorandil in patients with CSF. Patients and methods Thirty-six patients with CSF in the left anterior descending (LAD) branch and 20 patients with normal coronary arteries were included. Global and regional functions of the LV supplied by LAD were measured using conventional Doppler echocardiography and two-dimensional speckle tracking echocardiography, respectively, within 24 h after coronary angiography. Concentrations of plasma nitric oxide (NO) and endothelin-1 (ET-1) were detected using colorimetry and radioimmunoassay, respectively. The function of the LV and the levels of NO and ET-1 were also investigated before and 90 days after treatment with 15 mg/day of nicorandil. Results Compared with the control group, the early diastolic peak velocity (E), E/A ratio, and plasma NO levels were lower, whereas the late diastolic peak flow velocity (A) and plasma ET-1 levels were significantly higher in the CSF group (P<0.05). The longitudinal strain rate peak of the LV was reduced significantly in CSF patients (P<0.001). After treatment, 75% (27/36) of CSF patients were free of chest pain. The values of E peak, E/A ratio, longitudinal strain rate peak, and plasma NO level were increased (P<0.001), whereas the ET-1 level was decreased in CSF patients (P<0.001). Conclusion Nicorandil may improve chest pain symptoms and the impaired function of the LV, possibly by increasing plasma NO and reducing ET-1 in CSF. PMID:25325437

Real-time Assimilation of Altimeter Derived Synthetic Profiles Into a Global version of the Naval Research Laboratory's Coastal Ocean Model (NCOM)

NASA Astrophysics Data System (ADS)

Rhodes, R. C.; Barron, C. N.; Fox, D. N.; Smedstad, L. F.

2001-12-01

A global implementation of the Navy Coastal Ocean Model (NCOM), developed by the Naval Research Laboratory (NRL) at Stennis Space Center is currently running in real-time and is planned for transition to the Naval Oceanographic Office (NAVOCEANO) in 2002. The model encompasses the open ocean to 5 m depth on a curvilinear global model grid with 1/8 degree grid spacing at 45N, extending from 80 S to a complete arctic cap with grid singularities mapped into Canada and Russia. Vertically, the model employs 41 sigma-z levels with sigma in the upper-ocean and coastal regions and z in the deeper ocean. The Navy Operational Global Atmospheric Prediction System (NOGAPS) provides 6-hourly wind stresses and heat fluxes for forcing, while the operational Modular Ocean Data Assimilation System (MODAS) provides the background climatology and tools for data pre-processing. Operationally available sea surface temperature (SST) and altimetry (SSH) data are assimilated into the NAVOCEANO global 1/8 degree MODAS 2-D analysis and the 1/16 degree Navy Layered Ocean Model (NLOM) to provide analyses and forecasts of SSH and SST. The 2-D SSH and SST nowcast fields are used as input to the MODAS synthetic climatology database to yield three-dimensional fields of synthetic temperature and salinity for assimilation into global NCOM. The synthetic profiles are weighted higher at depth in the assimilation process to allow the numerical model to properly develop the mixed-layer structure driven by the real-time atmospheric forcing. Global NCOM nowcasts and forecasts provide a valuable resource for rapid response to the varied and often unpredictable operational requests for 3-dimensional fields of ocean temperature, salinity, and currents. In some cases, the resolution of the global product is sufficient for guidance. In cases requiring higher resolution, the global product offers a quick overview of local circulation and provides initial and boundary conditions for higher resolution coastal models that may be more specialized for a particular task or domain. Nowcast and forecast results are presented globally and in selected areas of interest and model results are compared with historical and concurrent observations and analyses.

Spatial Analysis of China Province-level Perinatal Mortality

PubMed Central

XIANG, Kun; SONG, Deyong

2016-01-01

Background: Using spatial analysis tools to determine the spatial patterns of China province-level perinatal mortality and using spatial econometric model to examine the impacts of health care resources and different socio-economic factors on perinatal mortality. Methods: The Global Moran’s I index is used to examine whether the spatial autocorrelation exists in selected regions and Moran’s I scatter plot to examine the spatial clustering among regions. Spatial econometric models are used to investigate the spatial relationships between perinatal mortality and contributing factors. Results: The overall Moran’s I index indicates that perinatal mortality displays positive spatial autocorrelation. Moran’s I scatter plot analysis implies that there is a significant clustering of mortality in both high-rate regions and low-rate regions. The spatial econometric models analyses confirm the existence of a direct link between perinatal mortality and health care resources, socio-economic factors. Conclusions: Since a positive spatial autocorrelation has been detected in China province-level perinatal mortality, the upgrading of regional economic development and medical service level will affect the mortality not only in region itself but also its adjacent regions. PMID:27398334

An Updated Global Picture of Cigarette Smoking Persistence among Adults

PubMed Central

Troost, Jonathan P.; Barondess, David A.; Storr, Carla L.; Wells, J. Elisabeth; Al-Hamzawi, Ali Obaid; Andrade, Laura Helena; Bromet, Evelyn; Bruffaerts, Ronny; Florescu, Silvia; de Girolamo, Giovanni; de Graaf, Ron; Gureje, Oye; Haro, Josep Maria; Hu, Chiyi; Huang, Yueqin; Karam, Aimee N.; Kessler, Ronald C.; Lepine, Jean-Pierre; Matschinger, Herbert; Medina-Mora, Maria Elena; O'Neill, Siobhan; Posada-Villa, Jose; Sagar, Rajesh; Takeshima, Tadashi; Tomov, Toma; Williams, David R.; Anthony, James C.

2012-01-01

Background Cross-national variance in smoking prevalence is relatively well documented. The aim of this study is to estimate levels of smoking persistence across 21 countries with a hypothesized inverse relationship between country income level and smoking persistence. Methods Data from the World Health Organization World Mental Health Survey Initiative were used to estimate cross-national differences in smoking persistence–the proportion of adults who started to smoke and persisted in smoking by the date of the survey. Result There is large variation in smoking persistence from 25% (Nigeria) to 85% (China), with a random-effects meta-analytic summary estimate of 55% with considerable cross-national variation. (Cochran's heterogeneity Q statistic=6,845; p<0.001). Meta-regressions indicated observed differences are not attributable to differences in country income level, age distribution of smokers, or how recent the onset of smoking began within each country. Conclusion While smoking should remain an important public health issue in any country where smokers are present, this report identifies several countries with higher levels of smoking persistence (namely, China and India). PMID:23626929

Widespread exposure to lead affects the body condition of free-living whooper swans Cygnus cygnus wintering in Britain.

PubMed

Newth, J L; Rees, E C; Cromie, R L; McDonald, R A; Bearhop, S; Pain, D J; Norton, G J; Deacon, C; Hilton, G M

2016-02-01

Lead poisoning, through the ingestion of spent lead gunshot, is an established cause of morbidity and mortality in waterbirds globally, but the thresholds at which blood levels begin to affect the physiology of birds in the wild are less well known. Here we determine the prevalence of lead exposure in whooper swans and, for the first time, identify the level of blood lead associated with initial reductions in body condition. Blood lead elevated above background levels (i.e. >20 μg dL(-1)) was found in 41.7% (125/300) of swans tested. Blood lead was significantly negatively associated with winter body condition when levels were ≥44 μg dL(-1) (27/260 = 10%). Our findings indicating that sub-lethal impacts of lead on body condition occur at the lower end of previously established clinical thresholds and that a relatively high proportion of individuals in this population may be affected, reaffirm the importance of reducing contamination of the environment with lead shot. Copyright © 2015 Elsevier Ltd. All rights reserved.

Genetic variants associated with fetal hemoglobin levels show the diverse ethnic origin in Colombian patients with sickle cell anemia.

PubMed

Fong, Cristian; Menzel, Stephan; Lizarralde, María Alejandra; Barreto, Guillermo

2015-01-01

Fetal hemoglobin is an important factor in modulating the severity of sickle cell anemia. Its level in peripheral blood underlies strong genetic determination. Associated loci with increased levels of fetal hemoglobin display population-specific allele frequencies. We investigated the presence and effect of known common genetic variants promoting fetal hemoglobin persistence (rs11886868, rs9399137, rs4895441, and rs7482144) in 60 Colombian patients with sickle cell anemia. Four single nucleotide polymorphisms (SNP) were genotyped by restriction fragment length polymorphisms (RFLP) and the use of the TaqMan procedure. Fetal hemoglobin (HbF) from these patients was quantified using the oxyhemoglobin alkaline denaturation technique. Genotype frequencies were compared with frequencies reported in global reference populations. We detected genetic variants in the four SNPs, reported to be associated with higher HbF levels for all four SNPs in the Colombian patients. Genetic association between SNPs and HbF levels did not reach statistical significance. The frequency of these variants reflected the specific ethnic make-up of our patient population: A high prevalence of rs7482144-'A' reflects the West-African origin of the sickle cell mutation, while high frequencies of rs4895441-'G' and rs11886868-'C' point to a significant influence of an Amerindian ethnic background in the Colombian sickle cell disease population. These results showed that in the sickle cell disease population in Colombia there is not a unique genetic background, but two (African and Amerindian). This unique genetic situation will provide opportunities for a further study of these loci, such as fine-mapping and molecular-biological investigation. Colombian patients are expected to yield a distinctive insight into the effect of modifier loci in sickle cell disease.

Penetration of Large Scale Electric Field to Inner Magnetosphere

NASA Astrophysics Data System (ADS)

Chen, S. H.; Fok, M. C. H.; Sibeck, D. G.; Wygant, J. R.; Spence, H. E.; Larsen, B.; Reeves, G. D.; Funsten, H. O.

2015-12-01

The direct penetration of large scale global electric field to the inner magnetosphere is a critical element in controlling how the background thermal plasma populates within the radiation belts. These plasma populations provide the source of particles and free energy needed for the generation and growth of various plasma waves that, at critical points of resonances in time and phase space, can scatter or energize radiation belt particles to regulate the flux level of the relativistic electrons in the system. At high geomagnetic activity levels, the distribution of large scale electric fields serves as an important indicator of how prevalence of strong wave-particle interactions extend over local times and radial distances. To understand the complex relationship between the global electric fields and thermal plasmas, particularly due to the ionospheric dynamo and the magnetospheric convection effects, and their relations to the geomagnetic activities, we analyze the electric field and cold plasma measurements from Van Allen Probes over more than two years period and simulate a geomagnetic storm event using Coupled Inner Magnetosphere-Ionosphere Model (CIMI). Our statistical analysis of the measurements from Van Allan Probes and CIMI simulations of the March 17, 2013 storm event indicate that: (1) Global dawn-dusk electric field can penetrate the inner magnetosphere inside the inner belt below L~2. (2) Stronger convections occurred in the dusk and midnight sectors than those in the noon and dawn sectors. (3) Strong convections at multiple locations exist at all activity levels but more complex at higher activity levels. (4) At the high activity levels, strongest convections occur in the midnight sectors at larger distances from the Earth and in the dusk sector at closer distances. (5) Two plasma populations of distinct ion temperature isotropies divided at L-Shell ~2, indicating distinct heating mechanisms between inner and outer radiation belts. (6) CIMI simulations reveal alternating penetration and shielding electric fields during the main phase of the geomagnetic storm, indicating an impulsive nature of the large scale penetrating electric field in regulating the gain and loss of radiation belt particles. We will present the statistical analysis and simulations results.

Gravitational and magnetic field variations synergize to cause subtle variations in the global transcriptional state of Arabidopsis in vitro callus cultures

PubMed Central

2012-01-01

Background Biological systems respond to changes in both the Earth's magnetic and gravitational fields, but as experiments in space are expensive and infrequent, Earth-based simulation techniques are required. A high gradient magnetic field can be used to levitate biological material, thereby simulating microgravity and can also create environments with a reduced or an enhanced level of gravity (g), although special attention should be paid to the possible effects of the magnetic field (B) itself. Results Using diamagnetic levitation, we exposed Arabidopsis thaliana in vitro callus cultures to five environments with different levels of effective gravity and magnetic field strengths. The environments included levitation, i.e. simulated μg* (close to 0 g* at B = 10.1 T), intermediate g* (0.1 g* at B = 14.7 T) and enhanced gravity levels (1.9 g* at B = 14.7 T and 2 g* at B = 10.1 T) plus an internal 1 g* control (B = 16.5 T). The asterisk denotes the presence of the background magnetic field, as opposed to the effective gravity environments in the absence of an applied magnetic field, created using a Random Position Machine (simulated μg) and a Large Diameter Centrifuge (2 g). Microarray analysis indicates that changes in the overall gene expression of cultured cells exposed to these unusual environments barely reach significance using an FDR algorithm. However, it was found that gravitational and magnetic fields produce synergistic variations in the steady state of the transcriptional profile of plants. Transcriptomic results confirm that high gradient magnetic fields (i.e. to create μg* and 2 g* conditions) have a significant effect, mainly on structural, abiotic stress genes and secondary metabolism genes, but these subtle gravitational effects are only observable using clustering methodologies. Conclusions A detailed microarray dataset analysis, based on clustering of similarly expressed genes (GEDI software), can detect underlying global-scale responses, which cannot be detected by means of individual gene expression techniques using raw or corrected p values (FDR). A subtle, but consistent, genome-scale response to hypogravity environments was found, which was opposite to the response in a hypergravity environment. PMID:22435851

Toxicodynamic modeling of 137Cs to estimate white-tailed deer background levels for the Department of Energy's Savannah River Site.

PubMed

Gaines, Karen F; Novak, James M; Bobryk, Christopher W; Blas, Susan A

2014-04-01

The U.S. Department of Energy's (USDOE) Savannah River Site (SRS) is a former nuclear weapon material production and current research facility adjacent to the Savannah River in South Carolina, USA. The purpose of this study was to determine the background radiocesium ((137)Cs) body burden (e.g., from global fallout) for white-tailed deer (Odocoileus virginianus) inhabiting the SRS. To differentiate what the background burden is for the SRS versus (137)Cs obtained from SRS nuclear activities, data were analyzed spatially, temporally and compared to other off-site hunting areas near the SRS. The specific objectives of this study were: to compare SRS and offsite deer herds based on time and space; to interpret comparisons based on how data were collected as well as the effect of environmental and anthropogenic influences; to determine what the ecological half-life/decay rate is for (137)Cs in the SRS deer herd; and to give a recommendation to what should be considered the background (137)Cs level in the SRS deer herd. Based on the available information and analyses, it is recommended that the determination of what is considered background for the SRS deer herd be derived from data collected from the SRS deer herd itself and not offsite collections for a variety of reasons. Offsite data show extreme variability most likely due to environmental factors such as soil type and land-use patterns (e.g., forest, agriculture, residential activities). This can be seen from results where samples from offsite military bases (Fort Jackson and Fort Stewart) without anthropogenic (137)Cs sources were much higher than both the SRS and a nearby (Sandhills) study site. Moreover, deer from private hunting grounds have the potential to be baited with corn, thus artificially lowering their (137)Cs body burdens compared to other free-ranging deer. Additionally, sample size for offsite collections were not robust enough to calculate a temporal decay curve with an upper confidence level to determine if the herds are following predicted radioactive decay rates like the SRS or if the variability is due to those points described above. Using mean yearly values, the ecological half-life for (137)Cs body burdens for SRS white-tailed deer was determined to be 28.79 years--very close to the 30.2 years physical half-life.

Designing Global Climate Change

NASA Astrophysics Data System (ADS)

Griffith, P. C.; ORyan, C.

2012-12-01

In a time when sensationalism rules the online world, it is best to keep things short. The people of the online world are not passing back and forth lengthy articles, but rather brief glimpses of complex information. This is the target audience we attempt to educate. Our challenge is then to attack not only ignorance, but also apathy toward global climate change, while conforming to popular modes of learning. When communicating our scientific material, it was difficult to determine what level of information was appropriate for our audience, especially with complex subject matter. Our unconventional approach for communicating the carbon crisis as it applies to global climate change caters to these 'recreational learners'. Using story-telling devices acquired from Carolyne's biomedical art background coupled with Peter's extensive knowledge of carbon cycle and ecosystems science, we developed a dynamic series of illustrations that capture the attention of a callous audience. Adapting complex carbon cycle and climate science into comic-book-style animations creates a channel between artist, scientist, and the general public. Brief scenes of information accompanied by text provide a perfect platform for visual learners, as well as fresh portrayals of stale material for the jaded. In this way art transcends the barriers of the cerebral and the abstract, paving the road to understanding.;

Fostering Reciprocity in Global Health Partnerships Through a Structured, Hands-On Experience for Visiting Postgraduate Medical Trainees

PubMed Central

Umoren, Rachel A.; Einterz, Robert M.; Litzelman, Debra K.; Pettigrew, Ronald K.; Ayaya, Samuel O.; Liechty, Edward A.

2014-01-01

Background Global health programs that allow international experiences for US learners should also enable reciprocal learning experiences for international learners, particularly if that is a need identified by the partner institution. Methods A partnership between Indiana University and Moi University, Kenya, has successfully hosted 41 visiting Kenyan internal medicine and pediatrics registrars at Indiana University since 2006. The program's logistics, curriculum, and evaluation are described. Results The registrars rotated through nephrology, cardiology, hematology and oncology, infectious diseases, and intensive care, as well as related ambulatory experiences, functioning on a level comparable to fourth-year medical students. They showed significant improvement in pretest and posttest scores on a standardized National Board of Medical Examiners examination (P  =  .048). International learners experienced culture shock, yet they felt the Indiana University elective was helpful and would recommend it to future participants. Conclusions Global health programs can reciprocate the benefits derived for US students and residents by offering learning experiences to international learners if that is an expressed need from the international partner. Barriers to those experiences can be overcome, and the hands-on, elective experience has the potential to positively affect the knowledge and attitudes of participants as well as the home nation. PMID:24949140

An emigration versus a globalization perspective of the Lebanese physician workforce: a qualitative study

PubMed Central

2012-01-01

Background Lebanon is witnessing an increased emigration of physicians. The objective of this study was to understand the perceptions of Lebanese policymakers of this emigration, and elicit their proposals for future policies and strategies to deal with this emigration. Methods We conducted semi-structured individual interviews with the deans of Lebanon’s seven medical schools, the presidents of the two physicians professional associations, and governmental officials. We analyzed the results qualitatively. Results Participants differed in the assessment of the extent and gravity of emigration. Lebanon has a surplus of physicians, driven largely by the over-production of graduates by a growing number of medical schools. Participants cited advantages and disadvantages of the emigration on the personal, financial, medical education system, healthcare system, and national levels. Proposed strategies included limiting the number of students entering medical schools, creating job opportunities for graduating students, and implementing quality standards. Most participants acknowledged the globalization of the Lebanese physician workforce, including exchanges with the Gulf region, exchanges with developed countries, and the involvement of North American medical education institutions in the region. Conclusion Many Lebanese policy makers, particularly deans of medical schools, perceive the emigration of the physician workforce as an opportunity in the context of the globalization of the profession. PMID:22646478

Socioeconomic Impact on the Prevalence of Cardiovascular Risk Factors in Wallonia, Belgium: A Population-Based Study.

PubMed

Streel, Sylvie; Donneau, Anne-Françoise; Hoge, Axelle; Majerus, Sven; Kolh, Philippe; Chapelle, Jean-Paul; Albert, Adelin; Guillaume, Michèle

2015-01-01

Background. Monitoring the epidemiology of cardiovascular risk factors (CRFs) and their determinants is important to develop appropriate recommendations to prevent cardiovascular diseases in specific risk groups. The NESCaV study was designed to collect standardized data to estimate the prevalence of CRFs in relation to socioeconomic parameters among the general adult population in the province of Liège, Wallonia, Belgium. Methods. A representative stratified random sample of 1017 subjects, aged 20-69 years, participated in the NESCaV study (2010-2012). A self-administered questionnaire, a clinical examination, and laboratory tests were performed on participants. CRFs included hypertension, dyslipidemia, global obesity, abdominal obesity, diabetes, current smoking, and physical inactivity. Covariates were education and subjective and objective socioeconomic levels. Data were analyzed by weighted logistic regression. Results. The prevalence of hypertension, abdominal obesity, global obesity, current smoking, and physical inactivity was higher in subjects with low education and who considered themselves "financially in need." Living below poverty threshold also increased the risk of global and abdominal obesity, current smoking, and physical inactivity. Conclusion. The study shows that socioeconomic factors impact the prevalence of CRFs in the adult population of Wallonia. Current public health policies should be adjusted to reduce health inequalities in specific risk groups.

PRECISE MEASUREMENT OF THE REIONIZATION OPTICAL DEPTH FROM THE GLOBAL 21 cm SIGNAL ACCOUNTING FOR COSMIC HEATING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fialkov, Anastasia; Loeb, Abraham, E-mail: anastasia.fialkov@cfa.harvard.edu, E-mail: aloeb@cfa.harvard.edu

2016-04-10

As a result of our limited data on reionization, the total optical depth for electron scattering, τ, limits precision measurements of cosmological parameters from the Cosmic Microwave Background (CMB). It was recently shown that the predicted 21 cm signal of neutral hydrogen contains enough information to reconstruct τ with sub-percent accuracy, assuming that the neutral gas was much hotter than the CMB throughout the entire epoch of reionization (EoR). Here we relax this assumption and use the global 21 cm signal alone to extract τ for realistic X-ray heating scenarios. We test our model-independent approach using mock data for amore » wide range of ionization and heating histories and show that an accurate measurement of the reionization optical depth at a sub-percent level is possible in most of the considered scenarios even when heating is not saturated during the EoR, assuming that the foregrounds are mitigated. However, we find that in cases where heating sources had hard X-ray spectra and their luminosity was close to or lower than what is predicted based on low-redshift observations, the global 21 cm signal alone is not a good tracer of the reionization history.« less

Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance

PubMed Central

Jeyapalan, J N; Noor, D A Mohamed; Lee, S-H; Tan, C L; Appleby, V A; Kilday, J P; Palmer, R D; Schwalbe, E C; Clifford, S C; Walker, D A; Murray, M J; Coleman, N; Nicholson, J C; Scotting, P J

2011-01-01

Background: Yolk sac tumours (YSTs) and germinomas are the two major pure histological subtypes of germ cell tumours. To date, the role of DNA methylation in the aetiology of this class of tumour has only been analysed in adult testicular forms and with respect to only a few genes. Methods: A bank of paediatric tumours was analysed for global methylation of LINE-1 repeat elements and global methylation of regulatory elements using GoldenGate methylation arrays. Results: Both germinomas and YSTs exhibited significant global hypomethylation of LINE-1 elements. However, in germinomas, methylation of gene regulatory regions differed little from control samples, whereas YSTs exhibited increased methylation at a large proportion of the loci tested, showing a ‘methylator' phenotype, including silencing of genes associated with Caspase-8-dependent apoptosis. Furthermore, we found that the methylator phenotype of YSTs was coincident with higher levels of expression of the DNA methyltransferase, DNA (cytosine-5)-methyltransferase 3B, suggesting a mechanism underlying the phenotype. Conclusion: Epigenetic silencing of a large number of potential tumour suppressor genes in YSTs might explain why they exhibit a more aggressive natural history than germinomas and silencing of genes associated with Caspase-8-dependent cell death might explain the relative resistance of YSTs to conventional therapy. PMID:21712824

A spatial approach for the epidemiology of antibiotic use and resistance in community-based studies: the emergence of urban clusters of Escherichia coli quinolone resistance in Sao Paulo, Brasil

PubMed Central

2011-01-01

Background Population antimicrobial use may influence resistance emergence. Resistance is an ecological phenomenon due to potential transmissibility. We investigated spatial and temporal patterns of ciprofloxacin (CIP) population consumption related to E. coli resistance emergence and dissemination in a major Brazilian city. A total of 4,372 urinary tract infection E. coli cases, with 723 CIP resistant, were identified in 2002 from two outpatient centres. Cases were address geocoded in a digital map. Raw CIP consumption data was transformed into usage density in DDDs by CIP selling points influence zones determination. A stochastic model coupled with a Geographical Information System was applied for relating resistance and usage density and for detecting city areas of high/low resistance risk. Results E. coli CIP resistant cluster emergence was detected and significantly related to usage density at a level of 5 to 9 CIP DDDs. There were clustered hot-spots and a significant global spatial variation in the residual resistance risk after allowing for usage density. Conclusions There were clustered hot-spots and a significant global spatial variation in the residual resistance risk after allowing for usage density. The usage density of 5-9 CIP DDDs per 1,000 inhabitants within the same influence zone was the resistance triggering level. This level led to E. coli resistance clustering, proving that individual resistance emergence and dissemination was affected by antimicrobial population consumption. PMID:21356088

Networks as systems.

PubMed

Best, Allan; Berland, Alex; Greenhalgh, Trisha; Bourgeault, Ivy L; Saul, Jessie E; Barker, Brittany

2018-03-19

Purpose The purpose of this paper is to present a case study of the World Health Organization's Global Healthcare Workforce Alliance (GHWA). Based on a commissioned evaluation of GHWA, it applies network theory and key concepts from systems thinking to explore network emergence, effectiveness, and evolution to over a ten-year period. The research was designed to provide high-level strategic guidance for further evolution of global governance in human resources for health (HRH). Design/methodology/approach Methods included a review of published literature on HRH governance and current practice in the field and an in-depth case study whose main data sources were relevant GHWA background documents and key informant interviews with GHWA leaders, staff, and stakeholders. Sampling was purposive and at a senior level, focusing on board members, executive directors, funders, and academics. Data were analyzed thematically with reference to systems theory and Shiffman's theory of network development. Findings Five key lessons emerged: effective management and leadership are critical; networks need to balance "tight" and "loose" approaches to their structure and processes; an active communication strategy is key to create and maintain support; the goals, priorities, and membership must be carefully focused; and the network needs to support shared measurement of progress on agreed-upon goals. Shiffman's middle-range network theory is a useful tool when guided by the principles of complex systems that illuminate dynamic situations and shifting interests as global alliances evolve. Research limitations/implications This study was implemented at the end of the ten-year funding cycle. A more continuous evaluation throughout the term would have provided richer understanding of issues. Experience and perspectives at the country level were not assessed. Practical implications Design and management of large, complex networks requires ongoing attention to key issues like leadership, and flexible structures and processes to accommodate the dynamic reality of these networks. Originality/value This case study builds on growing interest in the role of networks to foster large-scale change. The particular value rests on the longitudinal perspective on the evolution of a large, complex global network, and the use of theory to guide understanding.

Global baseline data on phosphorus pollution of large lakes

NASA Astrophysics Data System (ADS)

Fink, Gabriel; Flörke, Martina; Alcamo, Joseph

2016-04-01

Lakes are exposed to harmful eutrophication which is the most concerning water quality issue on global scale. Eutrophication is caused by phosphorous pollution in most lakes. Hence, global consistent base line data on phosphorus loadings are needed to assess future sustainable development. We used the modeling framework WaterGAP3 to calculate present total phosphorus loadings to the world's largest lakes. Estimates of modeled total phosphorus (TP) loadings as well as the contributions of different sectors were successfully validated against measured data. Based on these findings, annual total phosphorus loadings to lakes were calculated for diffuse and point sources according to the different sectors domestic, manufacturing, urban surface runoff, agriculture and background for the time period 1990 to 2010. Our results show high phosphorus loadings into lakes in southern latitudes. On global average, industrial fertilizer is the main anthropogenic source while background loadings are low in comparison. Nevertheless, both features indicate a high potential to reduce the exposure to eutrophication in lakes which are faced with high phosphor inputs. The global average of TP loadings was 7% higher in the time period 2005-2010 than in the period 1990-1995. The global average in 2005-2010 results from an increase in TP loadings of 79% in South America, which was dampened by a decrease in Europe, North America, and Asia. Chinese lakes were exposed to massive increasing phosphorus loadings, too. Both increasing and decreasing trends are caused primarily by changing industrial fertilizer application rates. In conclusion, this study provides a consistent and model based synopsis of global trends and sources of phosphorus loadings to large lakes. The estimates of phosphorus pollution of lakes present a basis for assessing and managing the global eutrophication problem.

A Study of Global Health Elective Outcomes

PubMed Central

Russ, Christiana M.; Tran, Tony; Silverman, Melanie; Palfrey, Judith

2017-01-01

Background and Objectives: To identify the effects of global health electives over a decade in a pediatric residency program. Methods: This was an anonymous email survey of the Boston Combined Residency alumni funded for global health electives from 2002 to 2011. A test for trend in binomial proportions and logistic regression were used to document associations between elective and participant characteristics and the effects of the electives. Qualitative data were also analyzed. Results: Of the 104 alumni with available email addresses, 69 (66%) responded, describing 94 electives. Elective products included 27 curricula developed, 11 conference presentations, and 7 academic publications. Thirty-two (46%) alumni continued global health work. Previous experience, previous travel to the site, number of global electives, and cumulative global elective time were associated with postresidency work in global health or with the underserved. Conclusions: Resident global electives resulted in significant scholarship and teaching and contributed to long-term career trajectories. PMID:28229096

The impact of half-a-degree Celsius upon the spatial pattern of future sea-level change.

NASA Astrophysics Data System (ADS)

Jackson, Luke

2017-04-01

It has been shown that the global thermal expansion of sea level and ocean dynamics are linearly related to global temperature change. On this basis one can estimate the difference in local sea-level change between a 1.5°C and 2.0°C world. The mitigation scenario RCP 2.6 shows an end-of-century global temperature range of 0.9 to 2.3°C (median 1.6°C). Additional sea-level components, such as mass changes in ice sheets, glaciers and land-water storage have unique spatial patterns that contribute to sea-level change and will be indirectly affected by global temperature change. We project local sea-level change for RCP 2.6 using sub-sets of models in the CMIP5 archive that follow different global temperature pathways. The method used to calculate local sea-level change is probabilistic and combines the normalised spatial patterns of sea-level components with global average projections of individual sea-level components.

Global multi-dimensional modeling of ionospheric electron density using GNSS measurements and IRI model

NASA Astrophysics Data System (ADS)

Alizadeh, M.; Schuh, H.; Schmidt, M. G.

2012-12-01

In the last decades Global Navigation Satellite System (GNSS) has turned into a promising tool for probing the ionosphere. The classical input data for developing Global Ionosphere Maps (GIM) is obtained from the dual-frequency GNSS observations. Simultaneous observations of GNSS code or carrier phase at each frequency is used to form a geometric-free linear combination which contains only the ionospheric refraction term and the differential inter-frequency hardware delays. To relate the ionospheric observable to the electron density, a model is used that represents an altitude-dependent distribution of the electron density. This study aims at developing a global multi-dimensional model of the electron density using simulated GNSS observations from about 150 International GNSS Service (IGS) ground stations. Due to the fact that IGS stations are in-homogenously distributed around the world and the accuracy and reliability of the developed models are considerably lower in the area not well covered with IGS ground stations, the International Reference Ionosphere (IRI) model has been used as a background model. The correction term is estimated by applying spherical harmonics expansion to the GNSS ionospheric observable. Within this study this observable is related to the electron density using different functions for the bottom-side and top-side ionosphere. The bottom-side ionosphere is represented by an alpha-Chapman function and the top-side ionosphere is represented using the newly proposed Vary-Chap function.aximum electron density, IRI background model (elec/m3), day 202 - 2010, 0 UT eight of maximum electron density, IRI background model (km), day 202 - 2010, 0 UT

Understanding students visions about environmental global problems. Experience and lessons learned of teaching in Lithuania.

NASA Astrophysics Data System (ADS)

Pereira, Paulo; Siarova, Hanna; Misiūnė, Ieva; Cerda, Artemi; Úbeda, Xavier

2015-04-01

Nowadays, environment is accepted to be an important element of our welfare. Our activities and societal status are strongly related with the quality of the environment where we live. On the other hand historical and cultural backgrounds shape importantly our views about the environment and how we act towards it in our daily life. In a context of globalization and increase of competition at international level, knowledge appears to be one of the key components for the advance of the word. Most of the knowledge produced comes from high level education institutions and research centres, which have responsibility to create and encourage critical thinking. Individuals aware of the problems can be more active and can push things forward. We think that environmental knowledge and awareness are fundamental for the future of the society. In order to develop better methodologies are developed if we have a better perception of students understanding of environmental problems. The objective of this work is to study the Lithuanian university level student's perception about some environmental challenges of our society. We selected several questions for the students rate according the relevance of the question, as "Air Pollution", "Waste Management", "Resources overexplotation", "Biodiversity reduction", "Human Overpopulation" "Poverty", "Global Warming/Climate change", Natural disasters", "Terrorism", "Economical crisis", "War and armed conflicts" and the "Spread of infectious diseases". We ask to the respondents to rate the importance using a likert scale (1=Not Important, 2= not so important, 3=important, 4=very important, 5=the most important). Among all the questions, the most rated where the Water pollution, the Spread of infectious diseases and Air Pollution and the less important where Biodiversity Reduction, Human overpopulation and climate change. These results helped us to identify where some efforts should be taken to raise student's awareness about global environmental problems. The awareness is different according to the gender. Normally females are more concerned than males about environmental questions. Students between the age of 18-24 are more concerned problems related to the Spread of infectious diseases and war and armed conflicts, while the respondents between the age of 25-39, rated higher Air pollution, Water pollution and Poverty. These preliminary results allowed us to identify potential topics that could be more explored at university level and increase the environmental awareness.

Promoting medical students’ reflection on competencies to advance a global health equities curriculum

PubMed Central

2014-01-01

Background The move to frame medical education in terms of competencies – the extent to which trainees “can do” a professional responsibility - is congruent with calls for accountability in medical education. However, the focus on competencies might be a poor fit with curricula intended to prepare students for responsibilities not emphasized in traditional medical education. This study examines an innovative approach to the use of potential competency expectations related to advancing global health equity to promote students’ reflections and to inform curriculum development. Methods In 2012, 32 medical students were admitted into a newly developed Global Health and Disparities (GHD) Path of Excellence. The GHD program takes the form of mentored co-curricular activities built around defined competencies related to professional development and leadership skills intended to ameliorate health disparities in medically underserved settings, both domestically and globally. Students reviewed the GHD competencies from two perspectives: a) their ability to perform the identified competencies that they perceived themselves as holding as they began the GHD program and b) the extent to which they perceived that their future career would require these responsibilities. For both sets of assessments the response scale ranged from “Strongly Disagree” to “Strongly Agree.” Wilcoxon’s paired T-tests compared individual students’ ordinal rating of their current level of ability to their perceived need for competence that they anticipated their careers would require. Statistical significance was set at p < .01. Results Students’ ratings ranged from “strongly disagree” to “strongly agree” that they could perform the defined GHD-related competencies. However, on most competencies, at least 50 % of students indicated that the stated competencies were beyond their present ability level. For each competency, the results of Wilcoxon paired T-tests indicate – at statistically significant levels - that students perceive more need in their careers for GHD-program defined competencies than they currently possess. Conclusion This study suggests congruence between student and program perceptions of the scope of practice required for GHD. Students report the need for enhanced skill levels in the careers they anticipate. This approach to formulating and reflecting on competencies will guide the program’s design of learning experiences aligned with students’ career goals. PMID:24886229

Prevalence and correlates of depersonalization in students aged 12-18 years in Germany.

PubMed

Michal, Matthias; Duven, Eva; Giralt, Sebastian; Dreier, Michael; Müller, Kai W; Adler, Julia; Beutel, Manfred E; Wölfling, Klaus

2015-06-01

Depersonalization (DP) involves unpleasant experiences of detachment from one's sense of self or unreality in the environment. DP may occur in a broad range of conditions, among healthy persons due to sleep loss, drug induced, secondary to anxiety disorders or primary in depersonalization disorder. Although DP has an early age of onset, little is known about the prevalence and correlates of DP among adolescents. Between January and June 2011, we conducted a questionnaire-based representative survey of pupils aged 12-18 years in the federal state Rhineland-Palatinate of Germany. The final sample comprised 3,809 pupils. We analyzed the prevalence of depersonalization and its correlates regarding sociodemographic characteristics, substance abuse, global mental distress and resilience factors. One-third of the sample showed severe global mental distress, and 11.9 % were in the range of clinically significant depersonalization. Depersonalized students were less often living with both parents (67.3 vs. 75.7 %), came more often from an disadvantaged socioeconomic background, had a very severe level of global mental distress (comparable to psychiatric inpatients), were more often smoking and abusing cannabis and they suffered from specific impairments regarding social insecurity, global self-efficacy and active coping abilities. Experiences of depersonalization were very common among adolescents and may indicate an increased risk for poor academic achievement and mental health in the long term. Prospective studies are needed to investigate the course and clinical relevance of depersonalization for the development of the adolescents.

Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression

PubMed Central

Richter, Karin; Wirta, Valtteri; Dahl, Lina; Bruce, Sara; Lundeberg, Joakim; Carlsson, Leif; Williams, Cecilia

2006-01-01

Background Expression of the LIM-homeobox gene Lhx2 in murine hematopoietic cells allows for the generation of hematopoietic stem cell (HSC)-like cell lines. To address the molecular basis of Lhx2 function, we generated HSC-like cell lines where Lhx2 expression is regulated by a tet-on system and hence dependent on the presence of doxycyclin (dox). These cell lines efficiently down-regulate Lhx2 expression upon dox withdrawal leading to a rapid differentiation into various myeloid cell types. Results Global gene expression of these cell lines cultured in dox was compared to different time points after dox withdrawal using microarray technology. We identified 267 differentially expressed genes. The majority of the genes overlapping with HSC-specific databases were those down-regulated after turning off Lhx2 expression and a majority of the genes overlapping with those defined as late progenitor-specific genes were the up-regulated genes, suggesting that these cell lines represent a relevant model system for normal HSCs also at the level of global gene expression. Moreover, in situ hybridisations of several genes down-regulated after dox withdrawal showed overlapping expression patterns with Lhx2 in various tissues during embryonic development. Conclusion Global gene expression analysis of HSC-like cell lines with inducible Lhx2 expression has identified genes putatively linked to self-renewal / differentiation of HSCs, and function of Lhx2 in organ development and stem / progenitor cells of non-hematopoietic origin. PMID:16600034

Urbanization and the global malaria recession

PubMed Central

2013-01-01

Background The past century has seen a significant contraction in the global extent of malaria transmission, resulting in over 50 countries being declared malaria free, and many regions of currently endemic countries eliminating the disease. Moreover, substantial reductions in transmission have been seen since 1900 in those areas that remain endemic today. Recent work showed that this malaria recession was unlikely to have been driven by climatic factors, and that control measures likely played a significant role. It has long been considered, however, that economic development, and particularly urbanization, has also been a causal factor. The urbanization process results in profound socio-economic and landscape changes that reduce malaria transmission, but the magnitude and extent of these effects on global endemicity reductions are poorly understood. Methods Global data at subnational spatial resolution on changes in malaria transmission intensity and urbanization trends over the past century were combined to examine the relationships seen over a range of spatial and temporal scales. Results/Conclusions A consistent pattern of increased urbanization coincident with decreasing malaria transmission and elimination over the past century was found. Whilst it remains challenging to untangle whether this increased urbanization resulted in decreased transmission, or that malaria reductions promoted development, the results point to a close relationship between the two, irrespective of national wealth. The continuing rapid urbanization in malaria-endemic regions suggests that such malaria declines are likely to continue, particularly catalyzed by increasing levels of direct malaria control. PMID:23594701

Mapping cortical hubs in tinnitus

PubMed Central

2009-01-01

Background Subjective tinnitus is the perception of a sound in the absence of any physical source. It has been shown that tinnitus is associated with hyperactivity of the auditory cortices. Accompanying this hyperactivity, changes in non-auditory brain structures have also been reported. However, there have been no studies on the long-range information flow between these regions. Results Using Magnetoencephalography, we investigated the long-range cortical networks of chronic tinnitus sufferers (n = 23) and healthy controls (n = 24) in the resting state. A beamforming technique was applied to reconstruct the brain activity at source level and the directed functional coupling between all voxels was analyzed by means of Partial Directed Coherence. Within a cortical network, hubs are brain structures that either influence a great number of other brain regions or that are influenced by a great number of other brain regions. By mapping the cortical hubs in tinnitus and controls we report fundamental group differences in the global networks, mainly in the gamma frequency range. The prefrontal cortex, the orbitofrontal cortex and the parieto-occipital region were core structures in this network. The information flow from the global network to the temporal cortex correlated positively with the strength of tinnitus distress. Conclusion With the present study we suggest that the hyperactivity of the temporal cortices in tinnitus is integrated in a global network of long-range cortical connectivity. Top-down influence from the global network on the temporal areas relates to the subjective strength of the tinnitus distress. PMID:19930625

Childhood socioeconomic status and risk in early family environments: predictors of global sleep quality in college students.

PubMed

Counts, Cory J; Grubin, Fiona C; John-Henderson, Neha A

2018-06-01

Low socioeconomic status (SES) in childhood associates with poor sleep quality in adulthood. Separately, childhood family environments shape health into adulthood. Here, we investigated whether these early life factors independently or interactively inform global sleep quality in college students. Cross-sectional. College students at a state university (N = 391). As a measure of childhood SES, we asked participants to consider their families' socioeconomic standing relative to the rest of the society during their childhood. We used the Risky Family questionnaire to measure adversity and the presence of warmth and affection in the family environment during childhood, and the Pittsburgh Sleep Quality Index as a measure of current global sleep quality. We used linear regressions adjusting for age and sex to examine relationships between childhood SES, risk in childhood family environments, and global sleep quality. Lower childhood SES and greater risk in childhood family environments independently predicted poor sleep quality. Importantly, in low-risk family environments, there was no significant difference in sleep quality as a function of childhood SES. However, students who were from low childhood SES backgrounds who also reported high levels of risk in their early family environments had the worst sleep quality. Findings highlight the importance of considering socioeconomic and family environments in childhood as informants of sleep quality across the lifespan. Compromised sleep quality in college students could affect academic performance and health over time. Copyright © 2018 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.

What do we mean by sensitivity analysis? The need for comprehensive characterization of "global" sensitivity in Earth and Environmental systems models

NASA Astrophysics Data System (ADS)

Razavi, Saman; Gupta, Hoshin V.

2015-05-01

Sensitivity analysis is an essential paradigm in Earth and Environmental Systems modeling. However, the term "sensitivity" has a clear definition, based in partial derivatives, only when specified locally around a particular point (e.g., optimal solution) in the problem space. Accordingly, no unique definition exists for "global sensitivity" across the problem space, when considering one or more model responses to different factors such as model parameters or forcings. A variety of approaches have been proposed for global sensitivity analysis, based on different philosophies and theories, and each of these formally characterizes a different "intuitive" understanding of sensitivity. These approaches focus on different properties of the model response at a fundamental level and may therefore lead to different (even conflicting) conclusions about the underlying sensitivities. Here we revisit the theoretical basis for sensitivity analysis, summarize and critically evaluate existing approaches in the literature, and demonstrate their flaws and shortcomings through conceptual examples. We also demonstrate the difficulty involved in interpreting "global" interaction effects, which may undermine the value of existing interpretive approaches. With this background, we identify several important properties of response surfaces that are associated with the understanding and interpretation of sensitivities in the context of Earth and Environmental System models. Finally, we highlight the need for a new, comprehensive framework for sensitivity analysis that effectively characterizes all of the important sensitivity-related properties of model response surfaces.

Atmospheric mercury deposition during the last 270 years--A glacial ice core record of natural and anthropogenic sources

USGS Publications Warehouse

Schuster, Paul F.; Krabbenhoft, David P.; Naftz, David L.; Cecil, L. DeWayne; Olson, Mark L.; DeWild, John F.; Susong, David D.; Green, Jaromy R.; Abbott, Michael L.

2002-01-01

Mercury (Hg) contamination of aquatic ecosystems and subsequent methylmercury bioaccumulation are significant environmental problems of global extent. At regional to global scales, the primary mechanism of Hg contamination is atmospheric Hg transport. Thus, a better understanding of the long-term history of atmospheric Hg cycling and quantification of the sources is critical for assessing the regional and global impact of anthropogenic Hg emissions. Ice cores collected from the Upper Fremont Glacier (UFG), Wyoming, contain a high-resolution record of total atmospheric Hg deposition (ca. 1720−1993). Total Hg in 97 ice-core samples was determined with trace-metal clean handling methods and low-level analytical procedures to reconstruct the first and most comprehensive atmospheric Hg deposition record of its kind yet available from North America. The record indicates major atmospheric releases of both natural and anthropogenic Hg from regional and global sources. Integrated over the past 270-year ice-core history, anthropogenic inputs contributed 52%, volcanic events 6%, and background sources 42%. More significantly, during the last 100 years, anthropogenic sources contributed 70% of the total Hg input. Unlike the 2−7-fold increase observed from preindustrial times (before 1840) to the mid-1980s in sediment-core records, the UFG record indicates a 20-fold increase for the same period. The sediment-core records, however, are in agreement with the last 10 years of this ice-core record, indicating declines in atmospheric Hg deposition.

Judgments of aircraft noise in a traffic noise background

NASA Technical Reports Server (NTRS)

Powell, C. A.; Rice, C. G.

1975-01-01

An investigation was conducted to determine subjective response to aircraft noise in different road traffic backgrounds. In addition, two laboratory techniques for presenting the aircraft noise with the background noise were evaluated. For one technique, the background noise was continuous over an entire test session; for the other, the background noise level was changed with each aircraft noise during a session. Subjective response to aircraft noise was found to decrease with increasing background noise level, for a range of typical indoor noise levels. Subjective response was found to be highly correlated with the Noise Pollution Level (NPL) measurement scale.

How Pedagogical Blogging Helps Prepare Students for Intercultural Communication in the Global Workplace

ERIC Educational Resources Information Center

Jaidev, Radhika

2014-01-01

Employees in the global workplace must be able to communicate effectively with interlocutors from different cultural backgrounds. To do this, they must be aware of the similarities and differences between their own and other cultures and of cultural biases that they and other people may have. This paper reports on the use of pedagogical blogging…

Interactive Videodisc Technology: Applications to the Air Command and Staff College Curriculum.

DTIC Science & Technology

1988-04-01

objectives )r Executive and NSC system Congress Military Intelligence community Media National environment Transcultural communications Global challenges...Cuban missile crisis REGIONAL STUDIES: USSR AND EUROPE Superpower global objectives The Soviet Union: background The Soviet political-economic system...summary National security affairs review The crisis game WARFARE STUDIES MILITARY HISTORY AND THEORY * - Overview to thinking about war Sun Tzu Great

Education under the Regime of PISA & Co.: Global Standards and Local Traditions in Conflict--The Case of Germany

ERIC Educational Resources Information Center

Münch, Richard

2014-01-01

Background: The PISA study (assessing the competences of 15-year-old students in their mother tongue, in mathematics and in natural sciences) deals with the benchmarking of the OECD member states when it comes to meeting globally defined educational standards. Transnational educational experts now form the most powerful group within the…

Equipping K-4 Children to Speak Any Foreign Language with an Authentic Accent

ERIC Educational Resources Information Center

Zuckermann, Ghil'ad; Benmark, Gadi

2010-01-01

In today's rapidly changing globalizing world, it is hard to predict which of many languages a child can learn today will be most useful to them twenty and thirty years from now, when they enter a global work place, interact socially with people from diverse cultural backgrounds, and may face relocation opportunities to foreign countries. Some…

Invisible Higher Education: Higher Education Institutions from Central and Eastern Europe in Global Rankings

ERIC Educational Resources Information Center

Boyadjieva, Pepka

2017-01-01

The starting point of this study is the argument that not only rankings of higher education institutions (HEIs) are inescapable, but so is the constant criticism to which they are subjected. Against this background, the paper discusses how HEIs from Central and Eastern Europe countries (CEECs) are (non)represented in the main global university…

When Will the Internet Be Connected? Digital Worlds and Belonging in the Lives of Globally Mobile Children

ERIC Educational Resources Information Center

Hannaford, Jeanette; Beavis, Catherine

2018-01-01

Increasing numbers of children are caught up in global flows of moving peoples. This movement may be voluntary or forced and is experienced within a range of settings. Coming from diverse linguistic and cultural backgrounds, and moving around the world due to their parents' employment, the children found in traditional International Schools are a…

Results of Global Youth Tobacco Surveys in Public Schools in Bogota, Colombia

ERIC Educational Resources Information Center

Pardo, Constanza; Pineros, Marion; Jones, Nathan R.; Warren, Charles W.

2010-01-01

Background: The purpose of this paper is to use data from the Global Youth Tobacco Survey (GYTS) conducted in Bogota, Colombia, in 2001 and 2007 to examine changes in tobacco use among youth 13-15 years of age. The current tobacco control effort in Bogota will be accessed relative to Colombia ratifying the World Health Organization Framework…

Journal Publication in Chile, Colombia, and Venezuela: University Responses to Global, Regional, and National Pressures and Trends

ERIC Educational Resources Information Center

Delgado, Jorge Enrique

2011-01-01

Background. This project was motivated by the impressive growth that scholarly/scientific journals in Latin America have shown in recent decades. That advance is attributed to global, regional, and national pressures and trends, as well as a response to obstacles that scholars/researchers from the region face to be published in prestigious…

Global earthquake fatalities and population

USGS Publications Warehouse

Holzer, Thomas L.; Savage, James C.

2013-01-01

Modern global earthquake fatalities can be separated into two components: (1) fatalities from an approximately constant annual background rate that is independent of world population growth and (2) fatalities caused by earthquakes with large human death tolls, the frequency of which is dependent on world population. Earthquakes with death tolls greater than 100,000 (and 50,000) have increased with world population and obey a nonstationary Poisson distribution with rate proportional to population. We predict that the number of earthquakes with death tolls greater than 100,000 (50,000) will increase in the 21st century to 8.7±3.3 (20.5±4.3) from 4 (7) observed in the 20th century if world population reaches 10.1 billion in 2100. Combining fatalities caused by the background rate with fatalities caused by catastrophic earthquakes (>100,000 fatalities) indicates global fatalities in the 21st century will be 2.57±0.64 million if the average post-1900 death toll for catastrophic earthquakes (193,000) is assumed.

Ionospheric reaction on sudden stratospheric warming events in Russiás Asia region

NASA Astrophysics Data System (ADS)

Polyakova, Anna; Perevalova, Natalya; Chernigovskaya, Marina

2015-12-01

The response of the ionosphere to sudden stratospheric warmings (SSWs) in the Asian region of Russia is studied. Two SSW events observed in 2008-2009 and 2012-2013 winter periods of extreme solar minimum and moderate solar maximum are considered. To detect the ionospheric effects caused by SSWs, we carried out a joint analysis of global ionospheric maps (GIM) of the total electron content (TEC), MLS (Microwave Limb Sounder, EOS Aura) measurements of temperature vertical profiles, as well as NCEP/NCAR and UKMO Reanalysis data. For the first time, it was found that during strong SSWs, in the mid-latitude ionosphere the amplitude of diurnal TEC variation decreases nearly half compared to quiet days. At the same time, the intensity of TEC deviations from the background level increases. It was also found that at SSW peak the midday TEC maximum decreases, and night/morning TEC values increase compared to quiet days. It was shown that during SSWs, TEC dynamics was identical for different geophysical conditions.The response of the ionosphere to sudden stratospheric warmings (SSWs) in the Asian region of Russia is studied. Two SSW events observed in 2008-2009 and 2012-2013 winter periods of extreme solar minimum and moderate solar maximum are considered. To detect the ionospheric effects caused by SSWs, we carried out a joint analysis of global ionospheric maps (GIM) of the total electron content (TEC), MLS (Microwave Limb Sounder, EOS Aura) measurements of temperature vertical profiles, as well as NCEP/NCAR and UKMO Reanalysis data. For the first time, it was found that during strong SSWs, in the mid-latitude ionosphere the amplitude of diurnal TEC variation decreases nearly half compared to quiet days. At the same time, the intensity of TEC deviations from the background level increases. It was also found that at SSW peak the midday TEC maximum decreases, and night/morning TEC values increase compared to quiet days. It was shown that during SSWs, TEC dynamics was identical for different geophysical conditions.

Kid Categories: A Comparison of the Category Productions of LSES and MSES Elementary School Children

ERIC Educational Resources Information Center

Williams, Rihana S.; Terry, Nicole Patton; Metzger, Isha

2013-01-01

The current study compares the productivity (number of responses) and the typical responses to taxonomic and slot-filler prompts in 39 African American children from low-income backgrounds and a diverse group of 21 children from middle-income backgrounds. The authors tested the hypothesis that socioeconomic status would exert a global influence on…

Three-dimensional ionospheric tomography reconstruction using the model function approach in Tikhonov regularization

NASA Astrophysics Data System (ADS)

Wang, Sicheng; Huang, Sixun; Xiang, Jie; Fang, Hanxian; Feng, Jian; Wang, Yu

2016-12-01

Ionospheric tomography is based on the observed slant total electron content (sTEC) along different satellite-receiver rays to reconstruct the three-dimensional electron density distributions. Due to incomplete measurements provided by the satellite-receiver geometry, it is a typical ill-posed problem, and how to overcome the ill-posedness is still a crucial content of research. In this paper, Tikhonov regularization method is used and the model function approach is applied to determine the optimal regularization parameter. This algorithm not only balances the weights between sTEC observations and background electron density field but also converges globally and rapidly. The background error covariance is given by multiplying background model variance and location-dependent spatial correlation, and the correlation model is developed by using sample statistics from an ensemble of the International Reference Ionosphere 2012 (IRI2012) model outputs. The Global Navigation Satellite System (GNSS) observations in China are used to present the reconstruction results, and measurements from two ionosondes are used to make independent validations. Both the test cases using artificial sTEC observations and actual GNSS sTEC measurements show that the regularization method can effectively improve the background model outputs.

What types of Level 3 products are available?

Atmospheric Science Data Center

2016-02-19

The Level 3 Component Global Georectified Radiation Product (CGGRP), Component Global Land Surface Product (CGLS), Component Global Aerosol Product (CGAS), and Component Global Albedo Product (CGAL) are generated for daily, monthly, quarterly,...

Developing a Scorecard to Assess Global Progress in Scaling Up Diarrhea Control Tools: A Qualitative Study of Academic Leaders and Implementers

PubMed Central

Rosinski, Alexander Anthony; Narine, Steven; Yamey, Gavin

2013-01-01

Background In 2010, diarrhea caused 0.75 million child deaths, accounting for nearly 12% of all under-five mortality worldwide. Many evidence-based interventions can reduce diarrhea mortality, including oral rehydration solution (ORS), zinc, and improved sanitation. Yet global coverage levels of such interventions remain low. A new scorecard of diarrhea control, showing how different countries are performing in their control efforts, could draw greater attention to the low coverage levels of proven interventions. Methods We conducted in-depth qualitative interviews with 21 experts, purposively sampled for their relevant academic or implementation expertise, to explore their views on (a) the value of a scorecard of global diarrhea control and (b) which indicators should be included in such a scorecard. We then conducted a ranking exercise in which we compiled a list of all 49 indicators suggested by the experts, sent the list to the 21 experts, and asked them to choose 10 indicators that they would include and 10 that they would exclude from such a scorecard. Finally, we created a “prototype” scorecard based on the 9 highest-ranked indicators. Results Key themes that emerged from coding the interview transcripts were: a scorecard could facilitate country comparisons; it could help to identify best practices, set priorities, and spur donor action; and it could help with goal-setting and accountability in diarrhea control. The nine highest ranking indicators, in descending order, were ORS coverage, rotavirus vaccine coverage, zinc coverage, diarrhea-specific mortality rate, diarrhea prevalence, proportion of population with access to improved sanitation, proportion with access to improved drinking water, exclusive breastfeeding coverage, and measles vaccine coverage. Conclusion A new scorecard of global diarrhea control could help track progress, focus prevention and treatment efforts on the most effective interventions, establish transparency and accountability, and alert donors and ministries of health to inadequacies in diarrhea control efforts. PMID:23874412

How students perceive medical competences: a cross-cultural study between the Medical Course in Portugal and African Portuguese Speaking Countries

PubMed Central

2011-01-01

Background A global effort has been made in the last years to establish a set of core competences that define the essential professional competence of a physician. Regardless of the environment, culture or medical education conditions, a set of core competences is required for medical practice worldwide. Evaluation of educational program is always needed to assure the best training for medical students and ultimately best care for patients. The aim of this study was to determine in what extent medical students in Portugal and Portuguese speaking African countries, felt they have acquired the core competences to start their clinical practice. For this reason, it was created a measurement tool to evaluate self-perceived competences, in different domains, across Portuguese and Portuguese-speaking African medical schools. Methods The information was collected through a questionnaire that defines the knowledge, attitudes and skills that future doctors should acquire. The Cronbach's Alpha and Principal Components Analysis (PCA) were used to evaluate the reliability of the questionnaire. In order to remove possible confounding effect, individual scores were standardized by country. Results The order of the domain's scores was similar between countries. After standardization, Personal Attitudes and Professional Behavior showed median scores above the country global median and Knowledge alone showed median score below the country global median. In Portugal, Clinical Skills showed score below the global median. In Angola, Clinical Skills and General Skills showed a similar result. There were only significant differences between countries in Personal Attitudes (p < 0.001) and Professional Behavior (p = 0.043). Conclusions The reliability of the instrument in Portuguese and Portuguese-speaking African medical schools was confirmed. Students have perceived their level of competence in personal attitudes in a high level and in opposite, knowledge and clinical skills with some weaknesses. PMID:21612609

Global health impacts of policies: lessons from the UK

PubMed Central

2014-01-01

Background The UK government committed to undertaking impact assessments of its policies on the health of populations in low and middle-income countries in its cross-government strategy “Health is Global”. To facilitate this process, the Department of Health, in collaboration with the National Heart Forum, initiated a project to pilot the use of a global health impact assessment guidance framework and toolkit for policy-makers. This paper aims to stimulate debate about the desirability and feasibility of global health impact assessments by describing and drawing lessons from the first stage of the project. Discussion Despite the attraction of being able to assess and address potential global health impacts of policies, there is a dearth of existing information and experience. A literature review was followed by discussions with policy-makers and an online survey about potential barriers, preferred support mechanisms and potential policies on which to pilot the toolkit. Although policy-makers were willing to engage in hypothetical discussions about the methodology, difficulties in identifying potential pilots suggest a wider problem in encouraging take up without legislative imperatives. This is reinforced by the findings of the survey that barriers to uptake included lack of time, resources and expertise. We identified three lessons for future efforts to mainstream global health impact assessments: 1) Identify a lead government department and champion – to some extent, this role was fulfilled by the Department of Health, however, it lacked a high-level cross-government mechanism to support implementation. 2) Ensure adequate resources and consider embedding the goals and principles of global health impact assessments into existing processes to maximise those resources. 3) Develop an effective delivery mechanism involving both state actors, and non-state actors who can ensure a “voice” for constituencies who are affected by government policies and also provide the “demand” for the assessments. Summary This paper uses the initial stages of a study on global health impact assessments to pose the wider question of incentives for policy-makers to improve global health. It highlights three lessons for successful development and implementation of global health impact assessments in relation to stewardship, resources, and delivery mechanisms. PMID:24612523

Antimony in recent, ombrotrophic peat from Switzerland and Scotland: Comparison with natural background values (5,320 to 8,020 14C yr BP) and implications for the global atmospheric Sb cycle

NASA Astrophysics Data System (ADS)

Shotyk, William; Krachler, Michael; Chen, Bin

2004-03-01

The lowest concentrations, atmospheric fluxes, and enrichments of Sb in a Swiss bog were found in peat samples dating from 8,020 to 5,320 14C yr BP when Sb inputs were proportional to those of Sc and effectively controlled by deposition of soil dust. For comparison with these ancient samples, modern peat samples from five rural areas of Switzerland and two remote areas of Scotland and Shetland are highly contaminated with Sb, with enrichments of the order of 30 to 80 times. "Lithogenic" Sb concentrations calculated using the Sc concentrations and background Sb/Sc ratio are dwarfed at all sites by "anthropogenic" Sb. The chronology and intensity of the Sb enrichments are in many ways similar to those of Pb which indicates that (1) Sb, like Pb, is well preserved in ombrotrophic peat and (2) the extent of human impacts on the geochemical cycle of Sb is comparable to that of Pb. The similar distribution of Sb and Pb can be explained in terms of their chemical and mineralogical associations, with most lead minerals being rich in Sb. Assuming that the "background" Sb flux (0.35 μg/m2/yr) from the Swiss bog is representative of preanthropogenic deposition rates worldwide, the global flux of natural Sb is estimated at 154 T/a. Using the natural Pb flux published by [1987] of 2600 T/a and the "background" Pb/Sb ratio (29) of the preanthropogenic peat samples, the global flux of natural Sb is estimated at 90 T/a. Either way, these values (90 to 154 T/a) are considerably lower than the current estimate of natural Sb to the global atmosphere (2400 T/a) published by [2001]. Assuming that the current estimate of anthropogenic Sb to the global atmosphere (1600 T/a) is correct [, 2001], the ratio of anthropogenic to natural Sb emissions is on the order of 10 to 18. Taken together, the data from modern and ancient peat samples suggests that the impact of human activities on the global geochemical cycle of Sb may have been underestimated by an order of magnitude. Like Pb, Sb has no known biological function, has a similar toxicity, and is a cumulative poison. The environmental geochemistry of Sb therefore may have a relevance to human and environmental health comparable to that of Pb.

Visual and Experiential Learning Opportunities through Geospatial Data

NASA Astrophysics Data System (ADS)

Gardiner, N.; Bulletins, S.

2007-12-01

Global observation data from satellites are essential for both research and education about Earth's climate because they help convey the temporal and spatial scales inherent to the subject, which are beyond most people's experience. Experts in the development of visualizations using spatial data distinguish the process of learning through data exploration from the process of learning by absorbing a story told from beginning to end. The former requires the viewer to absorb complex spatial and temporal dynamics inherent to visualized data and therefore is a process best undertaken by those familiar with the data and processes represented. The latter requires that the viewer understand the intended presentation of concepts, so story telling can be employed to educate viewers with varying backgrounds and familiarity with a given subject. Three examples of climate science education, drawn from the current science program Science Bulletins (American Museum of Natural History, New York, USA), demonstrate the power of visualized global earth observations for climate science education. The first example seeks to explain the potential for sea level rise on a global basis. A short feature film includes the visualized, projected effects of sea level rise at local to global scales; this visualization complements laboratory and field observations of glacier retreat and paleoclimatic reconstructions based on fossilized coral reef analysis, each of which is also depicted in the film. The narrative structure keeps learners focused on discrete scientific concepts. The second example utilizes half-hourly cloud observations to demonstrate weather and climate patterns to audiences on a global basis. Here, the scientific messages are qualitatively simpler, but the viewer must deduce his own complex visual understanding of the visualized data. Finally, we present plans for distributing climate science education products via mediated public events whereby participants learn from climate and geovisualization experts working collaboratively. This last example provides an opportunity for deep exploration of patterns and processes in a live setting and makes full use of complementary talents, including computer science, internet-enabled data sharing, remote sensing image processing, and meteorology. These innovative examples from informal educators serve as powerful pedagogical models to consider for the classroom of the future.

The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background

PubMed Central

Pound, Lynley D.; Sarkar, Suparna A.; Ustione, Alessandro; Dadi, Prasanna K.; Shadoan, Melanie K.; Lee, Catherine E.; Walters, Jay A.; Shiota, Masakazu; McGuinness, Owen P.; Jacobson, David A.; Piston, David W.; Hutton, John C.; Powell, David R.; O’Brien, Richard M.

2012-01-01

Objective The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes. Several groups have examined the effect of global Slc30a8 gene deletion but the results have been highly variable, perhaps due to the mixed 129SvEv/C57BL/6J genetic background of the mice studied. We therefore sought to remove the conflicting effect of 129SvEv-specific modifier genes. Methods The impact of Slc30a8 deletion was examined in the context of the pure C57BL/6J genetic background. Results Male C57BL/6J Slc30a8 knockout (KO) mice had normal fasting insulin levels and no change in glucose-stimulated insulin secretion (GSIS) from isolated islets in marked contrast to the ∼50% and ∼35% decrease, respectively, in both parameters observed in male mixed genetic background Slc30a8 KO mice. This observation suggests that 129SvEv-specific modifier genes modulate the impact of Slc30a8 deletion. In contrast, female C57BL/6J Slc30a8 KO mice had reduced (∼20%) fasting insulin levels, though this was not associated with a change in fasting blood glucose (FBG), or GSIS from isolated islets. This observation indicates that gender also modulates the impact of Slc30a8 deletion, though the physiological explanation as to why impaired insulin secretion is not accompanied by elevated FBG is unclear. Neither male nor female C57BL/6J Slc30a8 KO mice showed impaired glucose tolerance. Conclusions Our data suggest that, despite a marked reduction in islet zinc content, the absence of ZnT-8 does not have a substantial impact on mouse physiology. PMID:22829903

Long-term chloride concentrations in North American and European freshwater lakes

PubMed Central

Dugan, Hilary A.; Summers, Jamie C.; Skaff, Nicholas K.; Krivak-Tetley, Flora E.; Doubek, Jonathan P.; Burke, Samantha M.; Bartlett, Sarah L.; Arvola, Lauri; Jarjanazi, Hamdi; Korponai, János; Kleeberg, Andreas; Monet, Ghislaine; Monteith, Don; Moore, Karen; Rogora, Michela; Hanson, Paul C.; Weathers, Kathleen C.

2017-01-01

Anthropogenic sources of chloride in a lake catchment, including road salt, fertilizer, and wastewater, can elevate the chloride concentration in freshwater lakes above background levels. Rising chloride concentrations can impact lake ecology and ecosystem services such as fisheries and the use of lakes as drinking water sources. To analyze the spatial extent and magnitude of increasing chloride concentrations in freshwater lakes, we amassed a database of 529 lakes in Europe and North America that had greater than or equal to ten years of chloride data. For each lake, we calculated climate statistics of mean annual total precipitation and mean monthly air temperatures from gridded global datasets. We also quantified land cover metrics, including road density and impervious surface, in buffer zones of 100 to 1,500 m surrounding the perimeter of each lake. This database represents the largest global collection of lake chloride data. We hope that long-term water quality measurements in areas outside Europe and North America can be added to the database as they become available in the future. PMID:28786983

Long-term chloride concentrations in North American and European freshwater lakes.

PubMed

Dugan, Hilary A; Summers, Jamie C; Skaff, Nicholas K; Krivak-Tetley, Flora E; Doubek, Jonathan P; Burke, Samantha M; Bartlett, Sarah L; Arvola, Lauri; Jarjanazi, Hamdi; Korponai, János; Kleeberg, Andreas; Monet, Ghislaine; Monteith, Don; Moore, Karen; Rogora, Michela; Hanson, Paul C; Weathers, Kathleen C

2017-08-08

Anthropogenic sources of chloride in a lake catchment, including road salt, fertilizer, and wastewater, can elevate the chloride concentration in freshwater lakes above background levels. Rising chloride concentrations can impact lake ecology and ecosystem services such as fisheries and the use of lakes as drinking water sources. To analyze the spatial extent and magnitude of increasing chloride concentrations in freshwater lakes, we amassed a database of 529 lakes in Europe and North America that had greater than or equal to ten years of chloride data. For each lake, we calculated climate statistics of mean annual total precipitation and mean monthly air temperatures from gridded global datasets. We also quantified land cover metrics, including road density and impervious surface, in buffer zones of 100 to 1,500 m surrounding the perimeter of each lake. This database represents the largest global collection of lake chloride data. We hope that long-term water quality measurements in areas outside Europe and North America can be added to the database as they become available in the future.

Environmental health implications of global climate change.

PubMed

Watson, Robert T; Patz, Jonathan; Gubler, Duane J; Parson, Edward A; Vincent, James H

2005-09-01

This paper reviews the background that has led to the now almost-universally held opinion in the scientific community that global climate change is occurring and is inescapably linked with anthropogenic activity. The potential implications to human health are considerable and very diverse. These include, for example, the increased direct impacts of heat and of rises in sea level, exacerbated air and water-borne harmful agents, and--associated with all the preceding--the emergence of environmental refugees. Vector-borne diseases, in particular those associated with blood-sucking arthropods such as mosquitoes, may be significantly impacted, including redistribution of some of those diseases to areas not previously affected. Responses to possible impending environmental and public health crises must involve political and socio-economic considerations, adding even greater complexity to what is already a difficult challenge. In some areas, adjustments to national and international public health practices and policies may be effective, at least in the short and medium terms. But in others, more drastic measures will be required. Environmental monitoring, in its widest sense, will play a significant role in the future management of the problem.

Uneven futures of human lifespans: reckonings from Gompertz mortality rates, climate change, and air pollution.

PubMed

Finch, Caleb E; Beltrán-Sánchez, Hiram; Crimmins, Eileen M

2014-01-01

The past 200 years have enabled remarkable increases in human lifespans through improvements in the living environment that have nearly eliminated infections as a cause of death through improved hygiene, public health, medicine, and nutrition. We argue that the limit to lifespan may be approaching. Since 1997, no one has exceeded Jeanne Calment's record of 122.5 years, despite an exponential increase of centenarians. Moreover, the background mortality may be approaching a lower limit. We calculate from Gompertz coefficients that further increases in longevity to approach a life expectancy of 100 years in 21st century cohorts would require 50% slower mortality rate accelerations, which would be a fundamental change in the rate of human aging. Looking into the 21st century, we see further challenges to health and longevity from the continued burning of fossil fuels that contribute to air pollution as well as global warming. Besides increased heat waves to which elderly are vulnerable, global warming is anticipated to increase ozone levels and facilitate the spread of pathogens. We anticipate continuing socioeconomic disparities in life expectancy.

Conscious Vision Proceeds from Global to Local Content in Goal-Directed Tasks and Spontaneous Vision.

PubMed

Campana, Florence; Rebollo, Ignacio; Urai, Anne; Wyart, Valentin; Tallon-Baudry, Catherine

2016-05-11

The reverse hierarchy theory (Hochstein and Ahissar, 2002) makes strong, but so far untested, predictions on conscious vision. In this theory, local details encoded in lower-order visual areas are unconsciously processed before being automatically and rapidly combined into global information in higher-order visual areas, where conscious percepts emerge. Contingent on current goals, local details can afterward be consciously retrieved. This model therefore predicts that (1) global information is perceived faster than local details, (2) global information is computed regardless of task demands during early visual processing, and (3) spontaneous vision is dominated by global percepts. We designed novel textured stimuli that are, as opposed to the classic Navon's letters, truly hierarchical (i.e., where global information is solely defined by local information but where local and global orientations can still be manipulated separately). In line with the predictions, observers were systematically faster reporting global than local properties of those stimuli. Second, global information could be decoded from magneto-encephalographic data during early visual processing regardless of task demands. Last, spontaneous subjective reports were dominated by global information and the frequency and speed of spontaneous global perception correlated with the accuracy and speed in the global task. No such correlation was observed for local information. We therefore show that information at different levels of the visual hierarchy is not equally likely to become conscious; rather, conscious percepts emerge preferentially at a global level. We further show that spontaneous reports can be reliable and are tightly linked to objective performance at the global level. Is information encoded at different levels of the visual system (local details in low-level areas vs global shapes in high-level areas) equally likely to become conscious? We designed new hierarchical stimuli and provide the first empirical evidence based on behavioral and MEG data that global information encoded at high levels of the visual hierarchy dominates perception. This result held both in the presence and in the absence of task demands. The preferential emergence of percepts at high levels can account for two properties of conscious vision, namely, the dominance of global percepts and the feeling of visual richness reported independently of the perception of local details. Copyright © 2016 the authors 0270-6474/16/365200-14$15.00/0.

The New Global Health

PubMed Central

Simone, Patricia M.; Davison, Veronica; Slutsker, Laurence

2013-01-01

Global health reflects the realities of globalization, including worldwide dissemination of infectious and noninfectious public health risks. Global health architecture is complex and better coordination is needed between multiple organizations. Three overlapping themes determine global health action and prioritization: development, security, and public health. These themes play out against a background of demographic change, socioeconomic development, and urbanization. Infectious diseases remain critical factors, but are no longer the major cause of global illness and death. Traditional indicators of public health, such as maternal and infant mortality rates no longer describe the health status of whole societies; this change highlights the need for investment in vital registration and disease-specific reporting. Noncommunicable diseases, injuries, and mental health will require greater attention from the world in the future. The new global health requires broader engagement by health organizations and all countries for the objectives of health equity, access, and coverage as priorities beyond the Millennium Development Goals are set. PMID:23876365

An Unsupervised Deep Hyperspectral Anomaly Detector

PubMed Central

Ma, Ning; Peng, Yu; Wang, Shaojun

2018-01-01

Hyperspectral image (HSI) based detection has attracted considerable attention recently in agriculture, environmental protection and military applications as different wavelengths of light can be advantageously used to discriminate different types of objects. Unfortunately, estimating the background distribution and the detection of interesting local objects is not straightforward, and anomaly detectors may give false alarms. In this paper, a Deep Belief Network (DBN) based anomaly detector is proposed. The high-level features and reconstruction errors are learned through the network in a manner which is not affected by previous background distribution assumption. To reduce contamination by local anomalies, adaptive weights are constructed from reconstruction errors and statistical information. By using the code image which is generated during the inference of DBN and modified by adaptively updated weights, a local Euclidean distance between under test pixels and their neighboring pixels is used to determine the anomaly targets. Experimental results on synthetic and recorded HSI datasets show the performance of proposed method outperforms the classic global Reed-Xiaoli detector (RXD), local RX detector (LRXD) and the-state-of-the-art Collaborative Representation detector (CRD). PMID:29495410

Non-Contrast-Enhanced Renal Angiography Using Multiple Inversion Recovery and Alternating TR Balanced Steady State Free Precession

PubMed Central

Dong, Hattie Z.; Worters, Pauline W.; Wu, Holden H.; Ingle, R. Reeve; Vasanawala, Shreyas S.; Nishimura, Dwight G.

2014-01-01

Non-contrast enhanced renal angiography techniques based on balanced steady state free precession (SSFP) avoid external contrast agents, take advantage of high inherent blood signal from the T2/T1 contrast mechanism, and have short SSFP acquisition times. However, background suppression is limited; inflow times are inflexible; labeling region is difficult to define when tagging arterial flow; and scan times are long. To overcome these limitations, we propose the use of multiple inversion recovery (MIR) preparatory pulses combined with alternating TR balanced SSFP (ATR-SSFP) to produce renal angiograms. MIR uses selective spatial saturation followed by four global inversion recovery pulses to concurrently null a wide range of background T1 species while allowing for adjustable inflow times; ATR-SSFP maintains vessel contrast and provides added fat suppression. The high level of suppression enables imaging in 3D as well as projective 2D formats, the latter of which has a scan time down to one heartbeat. In vivo studies at 1.5 T demonstrate the superior vessel contrast of this technique. PMID:23172805

Endometriosis Is Characterized by a Distinct Pattern of Histone 3 and Histone 4 Lysine Modifications

PubMed Central

Monteiro, Janice B.; Colón-Díaz, Maricarmen; García, Miosotis; Gutierrez, Sylvia; Colón, Mariano; Seto, Edward; Laboy, Joaquín

2014-01-01

Background: The histone modification patterns in endometriosis have not been fully characterized. This gap in knowledge results in a poor understanding of the epigenetic mechanisms (and potential therapeutic targets) at play. We aimed to (1) assess global acetylation status of histone 3 (H3) and histone 4 (H4), (2) measure levels of H3 and H4 lysine (K) acetylation and methylation, and (3) to identify histone acetylation patterns in promoter regions of candidate genes in tissues from patients and controls. Methods: Global and K-specific acetylation/methylation levels of histones were measured in 24 lesions, 15 endometrium from patients, and 26 endometrium from controls. Chromatin immunoprecipitation (ChIP)–polymerase chain reaction was used to determine the histone acetylation status of the promoter regions of candidate genes in tissues. Results: The lesions were globally hypoacetylated at H3 (but not H4) compared to eutopic endometrium from controls. Lesions had significantly lower levels of H3K9ac and H4K16ac compared to eutopic endometrium from patients and controls. Tissues from patients were hypermethylated at H3K4, H3K9, and H3K27 compared to endometrium from controls. The ChIP analysis showed hypoacetylation of H3/H4 within promoter regions of candidate genes known to be downregulated in endometriosis (e.g., HOXA10, ESR1, CDH1, and p21WAF1/Cip1) in lesions versus control endometrium. The stereoidogenic factor 1 (SF1) promoter region was enriched for acetylated H3 and H4 in lesions versus control tissues, correlating with its reported high expression in lesions. Conclusions: This study describes the histone code of lesions and endometrium from patients with endometriosis and provides support for a possible role of histone modification in modulation of gene expression in endometriosis. PMID:23899551

Risk analysis reveals global hotspots for marine debris ingestion by sea turtles.

PubMed

Schuyler, Qamar A; Wilcox, Chris; Townsend, Kathy A; Wedemeyer-Strombel, Kathryn R; Balazs, George; van Sebille, Erik; Hardesty, Britta Denise

2016-02-01

Plastic marine debris pollution is rapidly becoming one of the critical environmental concerns facing wildlife in the 21st century. Here we present a risk analysis for plastic ingestion by sea turtles on a global scale. We combined global marine plastic distributions based on ocean drifter data with sea turtle habitat maps to predict exposure levels to plastic pollution. Empirical data from necropsies of deceased animals were then utilised to assess the consequence of exposure to plastics. We modelled the risk (probability of debris ingestion) by incorporating exposure to debris and consequence of exposure, and included life history stage, species of sea turtle and date of stranding observation as possible additional explanatory factors. Life history stage is the best predictor of debris ingestion, but the best-fit model also incorporates encounter rates within a limited distance from stranding location, marine debris predictions specific to the date of the stranding study and turtle species. There is no difference in ingestion rates between stranded turtles vs. those caught as bycatch from fishing activity, suggesting that stranded animals are not a biased representation of debris ingestion rates in the background population. Oceanic life-stage sea turtles are at the highest risk of debris ingestion, and olive ridley turtles are the most at-risk species. The regions of highest risk to global sea turtle populations are off of the east coasts of the USA, Australia and South Africa; the east Indian Ocean, and Southeast Asia. Model results can be used to predict the number of sea turtles globally at risk of debris ingestion. Based on currently available data, initial calculations indicate that up to 52% of sea turtles may have ingested debris. © 2015 John Wiley & Sons Ltd.

Corruption Kills: Estimating the Global Impact of Corruption on Children Deaths

PubMed Central

Hanf, Matthieu; Van-Melle, Astrid; Fraisse, Florence; Roger, Amaury; Carme, Bernard; Nacher, Mathieu

2011-01-01

Background Information on the global risk factors of children mortality is crucial to guide global efforts to improve survival. Corruption has been previously shown to significantly impact on child mortality. However no recent quantification of its current impact is available. Methods The impact of corruption was assessed through crude Pearson's correlation, univariate and multivariate linear models coupling national under-five mortality rates in 2008 to the national “perceived level of corruption” (CPI) and a large set of adjustment variables measured during the same period. Findings The final multivariable model (adjusted R2 = 0.89) included the following significant variables: percentage of people with improved sanitation (p.value<0.001), logarithm of total health expenditure (p.value = 0.006), Corruption Perception Index (p.value<0.001), presence of an arid climate on the national territory (p = 0.006), and the dependency ratio (p.value<0.001). A decrease in CPI of one point (i.e. a more important perceived corruption) was associated with an increase in the log of national under-five mortality rate of 0.0644. According to this result, it could be roughly hypothesized that more than 140000 annual children deaths could be indirectly attributed to corruption. Interpretations Global response to children mortality must involve a necessary increase in funds available to develop water and sanitation access and purchase new methods for prevention, management, and treatment of major diseases drawing the global pattern of children deaths. However without paying regard to the anti-corruption mechanisms needed to ensure their proper use, it will also provide further opportunity for corruption. Policies and interventions supported by governments and donors must integrate initiatives that recognise how they are inter-related. PMID:22073233

Risk Analysis Reveals Global Hotspots for Marine Debris Ingestion by Sea Turtles

NASA Astrophysics Data System (ADS)

Schuyler, Q. A.; Wilcox, C.; Townsend, K.; Wedemeyer-Strombel, K.; Balazs, G.; van Sebille, E.; Hardesty, B. D.

2016-02-01

Plastic marine debris pollution is rapidly becoming one of the critical environmental concerns facing wildlife in the 21st century. Here we present a risk analysis for plastic ingestion by sea turtles on a global scale. We combined global marine plastic distributions based on ocean drifter data with sea turtle habitat maps to predict exposure levels to plastic pollution. Empirical data from necropsies of deceased animals were then utilised to assess the consequence of exposure to plastics. We modelled the risk (probability of debris ingestion) by incorporating exposure to debris and consequence of exposure, and included life history stage, species of sea turtle, and date of stranding observation as possible additional explanatory factors. Life history stage is the best predictor of debris ingestion, but the best-fit model also incorporates encounter rates within a limited distance from stranding location, marine debris predictions specific to the date of the stranding study, and turtle species. There was no difference in ingestion rates between stranded turtles vs. those caught as bycatch from fishing activity, suggesting that stranded animals are not a biased representation of debris ingestion rates in the background population. Oceanic life-stage sea turtles are at the highest risk of debris ingestion, and olive ridley turtles are the most at-risk species. The regions of highest risk to global sea turtle populations are off of the east coasts of the USA, Australia, and South Africa; the east Indian Ocean, and Southeast Asia. Model results can be used to predict the number of sea turtles globally at risk of debris ingestion. Based on currently available data, initial calculations indicate that up to 52% of sea turtles may have ingested debris.

On Natality in Our Roots, Routes, and Relations: Reconceiving the "3 R's" at the Rendezvous of Education, Citizenship, and Globalization

ERIC Educational Resources Information Center

Quinn, Molly

2011-01-01

Background/Context: This essay is a part of a special issue that emerges from a year-long faculty seminar at Teachers College, Columbia University. The seminar's purpose has been to examine in fresh terms the nexus of globalization, education, and citizenship. Participants come from diverse fields of research and practice, among them art…

Globally Convergent Numerical Methods for Coefficient Inverse Problems

DTIC Science & Technology

2008-09-23

backgrounds. Probing radiations are usually thought as electric and acoustic waves for the first two applications and light originated by lasers in...fundamental laws of physics. Electric , acoustic or light scattering properties of both unknown targets and the backgrounds are described by coefficients of...with the back-reflected data here, Army applications are quite feasible. The 2-D inverse problem of the determination of the unknown electric

Global meaning in people with spinal cord injury: Content and changes

PubMed Central

Littooij, Elsbeth; Widdershoven, Guy A.M.; Stolwijk-Swüste, Janneke M.; Doodeman, Suzan; Leget, Carlo J.W.; Dekker, Joost

2016-01-01

Background After spinal cord injury (SCI), people are confronted with abrupt discontinuity in almost all areas of life, leading to questions on how to live a meaningful life again. Global meaning refers to basic ideas and goals that guide people in giving meaning to their lives, in specific situations. Little is known about global meaning relating to SCI and whether global meaning changes after SCI. Purpose The purpose of this study was twofold: (i) to explore the content of global meaning of people with SCI, and (ii) to explore whether or not global meaning changes after SCI. Methods In-depth semi-structured interviews were conducted with 16 people with SCI. Interviews were analyzed according to the method of grounded theory. Results (i) Five aspects of global meaning were found: core values, relationships, worldview, identity and inner posture. (ii) Overall, little change in the content of global meaning was found after SCI; specific aspects of global meaning were foregrounded after SCI. Conclusion Five aspects of global meaning were found in people with SCI. Global meaning seems hardly subject to change. PMID:25615571

Global constraints on vector-like WIMP effective interactions

DOE PAGES

Blennow, Mattias; Coloma, Pilar; Fernandez-Martinez, Enrique; ...

2016-04-07

In this work we combine information from relic abundance, direct detection, cosmic microwave background, positron fraction, gamma rays, and colliders to explore the existing constraints on couplings between Dark Matter and Standard Model constituents when no underlying model or correlation is assumed. For definiteness, we include independent vector-like effective interactions for each Standard Model fermion. Our results show that low Dark Matter masses below 20 GeV are disfavoured at the 3 σ  level with respect to higher masses, due to the tension between the relic abundance requirement and upper constraints on the Dark Matter couplings. Lastly, large couplings are typically onlymore » allowed in combinations which avoid effective couplings to the nuclei used in direct detection experiments.« less

Residues of organochlorine pesticides in soils from the southern Sonora, Mexico.

PubMed

Cantu-Soto, E U; Meza-Montenegro, Maria Mercedes; Valenzuela-Quintanar, A I; Félix-Fuentes, A; Grajeda-Cota, P; Balderas-Cortes, J J; Osorio-Rosas, C L; Acuña-García, G; Aguilar-Apodaca, M G

2011-11-01

Although, the Yaqui and Mayo valleys are the most important agricultural areas in Sonora, there is only limited data of the pesticides residue in soils in these valleys. This study measured the organochlorine pesticides (OCPs) in 234 soil samples (residential and agricultural) from 24 communities. The global results (mean, range) indicated that benzene hexachloride (19.2, ND-938.5 μg g(-1)), endrin (6.6, ND-377.3 μg g(-1)) and DDTs (36.45, ND-679.7 μg g(-1)) were the dominant contaminants. Soil is one of the most important routes of exposure to OCPs in the population of southern Sonora and this study can be used to establish background levels of OCPs.

Guatemala's ministry of health rapid response team manuals.

PubMed

Hernandez, Luis; Hanson, Kimberly M; Martel, Lise D

2014-01-01

The function of public health rapid response teams (RRTs) is to quickly identify, investigate, and control an outbreak before it can spread. The Central America Regional Office in Guatemala provided assistance to the Guatemalan Ministry of Health and Social Assistance (MSPAS) to develop RRT manuals at the district and regional levels. The manuals are divided into 4 sections: background, activity lists, standard operating procedures, and annexes. The manuals outline Guatemala's RRT members' responsibilities and will be tested in the near future through tabletop exercises. The development of the manuals is a concrete and significant step toward the attainment of Guatemala's IHR goals and should be integrated into a larger emergency management system to promote "a world safe and secure from global health threats posed by infectious diseases."

Diurnal variations of ELF transients and background noise in the Schumann resonance band

NASA Astrophysics Data System (ADS)

Greenberg, Eran; Price, Colin

2007-02-01

Schumann resonances (SR) are resonant electromagnetic waves in the Earth-ionosphere cavity, induced primarily by lightning discharges, with a fundamental frequency of about 8 Hz and higher-order modes separated by approximately 6 Hz. The SR are made up of the background signal resulting from global lightning activity and extremely low frequency (ELF) transients resulting from particularly intense lightning discharges somewhere on the planet. Since transients within the Earth-ionosphere cavity due to lightning propagate globally in the ELF range, we can monitor and study global ELF transients from a single station. Data from our Negev Desert (Israel) ELF site are collected using two horizontal magnetic induction coils and a vertical electric field ball antenna, monitored in the 5-40 Hz range with a sampling frequency of 250 Hz. In this paper we present statistics related to the probability distribution of ELF transients and background noise in the time domain and its temporal variations during the day. Our results show that the ELF signal in the time domain follows the normal distribution very well. The σ parameter exhibits three peaks at 0800, 1400, and 2000 UT, which are related to the three main global lightning activity centers in Asia, Africa, and America, respectively. Furthermore, the occurrence of intense ELF events obeys the Poisson distribution, with such intense events occurring every ~10 s, depending on the time of the day. We found that the diurnal changes of the σ parameter are several percent of the mean, while for the number of intense events per minute, the diurnal changes are tens of percent about the mean. We also present the diurnal changes of the SR intensities in the frequency domain as observed at our station. To better understand the diurnal variability of the observations, we simulated the measured ELF background noise using space observations as input, as detected by the Optical Transient Detector (OTD). The most active center which is reflected from both ELF measurements and OTD observations is in Africa. However, the second most active center on the basis of ELF measurements appears to be Asia, while OTD observations show that the American center is more active than the Asian center. These differences are discussed. This paper contributes to our understanding of the origin of the SR by comparing different lightning data sets: background electromagnetic radiation and optical emission observed from space.

A Teleconnection between the West Siberian Plain and the ENSO Region

NASA Astrophysics Data System (ADS)

Liess, S.; Agrawal, S.; Chatterjee, S.; Kumar, V.

2017-12-01

This study presents a mechanism that links the El Niño/Southern Oscillation (ENSO) to extratropical waves that are deflected from the Northern Hemisphere polar regions and travel southeastward over Central Asia toward the west Pacific warm pool during northern winter. The initial wave pattern resembles the well-known East Atlantic-West Russia pattern. Here we show its influence on the ENSO region. We identify a tripole pattern between the West Siberian Plain and the two centers of action of ENSO with a graph-based approach. It indicates that the background state of ENSO with respect to global sea level pressure (SLP) has a significant negative correlation to the West Siberian Plain. The correlation with the background state, which is defined by the sum of the two centers of action of ENSO, is higher than each of the pairwise correlations with either of the ENSO centers alone. We define the centers with a clustering algorithm that detects regions with similar characteristics. The normalized monthly SLP time series for the two centers of ENSO (around Darwin, Australia and Tahiti) are area-averaged and the sum of both regions is considered as the background state of ENSO. This wave train can be detected throughout the troposphere and the lower stratosphere. Its origins can be traced back to atmospheric wave activity triggered by convection over the subtropical North Atlantic that emanates wave activity toward the West Siberian Plain. The same wave train also propagates to the central Pacific Ocean around Tahiti and can be used to predict the background state over the ENSO region. This background state also modifies the subtropical bridge between the tropical east Pacific and the subtropical North Atlantic, thus leading to a circumglobal wave train.

Mercury pollution by gold mining in a global biodiversity hotspot, the Choco biogeographic region, Colombia.

PubMed

Palacios-Torres, Yuber; Caballero-Gallardo, Karina; Olivero-Verbel, Jesus

2018-02-01

Mercury (Hg) is a harmful pollutant released into the environment from gold mining activities, representing a risk to human health and the ecosystems. The aim of this study was to assess the levels of total Hg (T-Hg) in human hair, fish, sediments and air; and to determine fish consumption-based risks for T-Hg ingestion in the Choco biogeographic region, a global biodiversity hotspot located at the Colombian Pacific. Mercury concentrations in hair were measured in two locations, Quibdo, the state capital, and Paimado, a riverine community. The median T-Hg value in human hair in Quibdo was 1.26 μg/g (range: 0.02-116.40 μg/g), whereas in Paimado it was 0.67 μg/g (range: 0.07-6.47 μg/g). Mercury levels in examined locations were weakly associated with height (ρ = 0.145, P = 0.024). Air T-Hg levels in Quibdo were high inside gold shops being up to 200.9-fold greater than the background. Mercury concentrations in fish from Atrato River were above WHO limit (0.5 μg/g), with highest levels in Pseudopimelodus schultzi, Ageneiosus pardalis, Sternopygus aequilabiatus, Rhamdia quelen and Hoplias malabaricus, whereas the lowest appeared in Cyphocharax magdalenae and Hemiancistrus wilsoni. Based on fish consumption, these last two species offer low risk to human health. Sediment samples from fifty different sites of Atrato River showed low T-Hg concentrations, with little variability between stations. However, contamination factors revealed a moderate pollution in 44% of sampling sites along the river. In conclusion, Hg pollution is widespread in the Biogeographic Choco and governmental actions must be taken to protect the population and preserve its biodiversity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Emotions and emotion regulation in survivors of childhood sexual abuse: the importance of “disgust” in traumatic stress and psychopathology

PubMed Central

Coyle, Eimear; Karatzias, Thanos; Summers, Andy; Power, Mick

2014-01-01

Background Childhood sexual abuse (CSA) has the potential to compromise socio-emotional development of the survivor resulting in increased vulnerability to difficulties regulating emotions. In turn, emotion regulation is thought to play a key part in a number of psychological disorders which CSA survivors are at increased risk of developing. A better understanding of the basic emotions experienced in this population and emotion regulation strategies will inform current treatment. Objective This paper examines the relationships between type of emotions experienced, emotion regulation strategies, and psychological trauma symptoms in a sample of survivors of CSA. Method A consecutive case series of CSA survivors (n=109) completed the Basic Emotions Scale (BES)—Weekly, General, and Coping versions; the Regulation of Emotions Questionnaire; the Post-traumatic Stress Checklist—Civilian Version (PCL-C); and the Clinical Outcomes in Routine Evaluation Outcome Measure. Results Significantly higher levels of disgust than other levels of emotions were reported on the weekly version of the BES. In addition, significantly higher levels of disgust and lower levels of happiness were reported on the BES—General subscale. Regression analyses revealed that sadness, fear, disgust, and external dysfunctional coping strategies predicted global post-traumatic stress disorder and re-experiencing symptomatology measured by the PCL-C. Global distress, as measured by CORE, was predicted by the emotions of sadness, disgust, and low happiness, as well as dysfunctional regulatory strategies. In addition, preliminary exploratory factor analyses supported the structure of all three versions of the BES, with disgust explaining the largest percentage of variance, followed by happiness. Conclusions The findings highlight the utility of profiling basic emotions in understanding the strong associations between emotional phenomena, particularly the emotion of disgust and psychopathology in CSA survivors. PMID:24936284

Exploring the relationships between patient characteristics and their dialysis care experience.

PubMed

van der Veer, Sabine N; Arah, Onyebuchi A; Visserman, Ella; Bart, Hans A J; de Keizer, Nicolette F; Abu-Hanna, Ameen; Heuveling, Lara M; Stronks, Karien; Jager, Kitty J

2012-11-01

Previous studies have shown that it is possible for patient experience to be influenced by factors that are not attributable to health-care. Therefore, if patient experience is to be used as an accurate indicator of clinical performance, then it is important to understand its determinants. We used data from 840 dialysis patients who completed a validated patient experience survey. We created a potential theoretical framework based on available clinical knowledge to hypothesize the relationships between 13 demographic, socio-economic and health status factors and three outcome measures: global rating of the dialysis centre and the patient experience with the nephrologist's and nurses' care. The theoretical framework guided the selection of confounding variables for each determinant, which were then entered as terms in multivariable linear regression models. Patients who were of older age, of non-European decent, and who had a lower educational level, lower albumin level, with better self-rated health and who were without co-morbidities reported higher global ratings with the dialysis centre than their counterparts. Past myocardial infarction and better self-rated health were found to be determinants of a more positive experience while in the nephrologist's care. A more positive experience with nurses' care was associated with factors including older age, Dutch origin background, lower educational level, lower albumin levels and better self-rated health. Several characteristics of dialysis patients influence the way they rate and experience their care. When using the patient experience and ratings as indicators of clinical performance, they should be adjusted for such factors as identified in our study. This will facilitate a meaningful comparison of dialysis centres, and enable informed decision making by patients, insurers and policy makers.

Cosmic microwave background constraints for global strings and global monopoles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lopez-Eiguren, Asier; Lizarraga, Joanes; Urrestilla, Jon

We present the first cosmic microwave background (CMB) power spectra from numerical simulations of the global O( N ) linear σ-model, with N =2,3, which have global strings and monopoles as topological defects. In order to compute the CMB power spectra we compute the unequal time correlators (UETCs) of the energy-momentum tensor, showing that they fall off at high wave number faster than naive estimates based on the geometry of the defects, indicating non-trivial (anti-)correlations between the defects and the surrounding Goldstone boson field. We obtain source functions for Einstein-Boltzmann solvers from the UETCs, using a recently developed method thatmore » improves the modelling at the radiation-matter transition. We show that the interpolation function that mimics the transition is similar to other defect models, but not identical, confirming the non-universality of the interpolation function. The CMB power spectra for global strings and global monopoles have the same overall shape as those obtained using the non-linear σ-model approximation, which is well captured by a large- N calculation. However, the amplitudes are larger than the large- N calculation would naively predict, and in the case of global strings much larger: a factor of 20 at the peak. Finally we compare the CMB power spectra with the latest CMB data in other to put limits on the allowed contribution to the temperature power spectrum at multipole l = 10 of 1.7% for global strings and 2.4% for global monopoles. These limits correspond to symmetry-breaking scales of 2.9× 10{sup 15} GeV (6.3× 10{sup 14} GeV with the expected logarithmic scaling of the effective string tension between the simulation time and decoupling) and 6.4× 10{sup 15} GeV respectively. The bound on global strings is a significant one for the ultra-light axion scenario with axion masses m {sub a} ∼< 10{sup −28} eV . These upper limits indicate that gravitational waves from global topological defects will not be observable at the gravitational wave observatory LISA.« less

Regional and global contributions of anthropogenic iodine-129 in monthly deposition samples collected in North East Japan between 2006 and 2015.

PubMed

Hasegawa, Hidenao; Kakiuchi, Hideki; Akata, Naofumi; Ohtsuka, Yoshihito; Hisamatsu, Shun'ichi

2017-05-01

We measured the monthly atmospheric deposition flux of 129 I at Rokkasho, Aomori, Japan-the location of a commercial spent nuclear fuel reprocessing plant-from 2006 to 2015 to assess the impact of the plant on environmental 129 I levels. The plant is now under final safety assessment by a national authority after test operation using actual spent nuclear fuel. During cutting and chemical processing in test operations from April 2006 to October 2008, 129 I was discharged to the atmosphere and detected in our deposition samples. 129 I deposition fluxes largely followed the discharge pattern of 129 I from the plant to the atmosphere, and most of the deposited 129 I originated from the plant. In and after 2009, 129 I deposition fluxes decreased dramatically to reach the background level; the 129 I deposition fluxes at Rokkasho were almost the same as those at Hirosaki, where an additional sampling point was set up as a background site 85 km from the plant in 2011. The background 129 I deposition fluxes showed seasonal variation-high in winter and low in the other seasons-at both Rokkasho and Hirosaki. The results of a backward trajectory analysis of the air mass at Rokkasho suggested that reprocessing plants in Europe were the origins of the high 129 I flux in winter. The contribution of 129 I released from the Fukushima Dai-ichi Nuclear Power Plant accident to the 129 I deposition flux at Rokkasho in 2011 was small on the basis of the 129 I/ 131 I activity ratio. Copyright © 2017 Elsevier Ltd. All rights reserved.

Searching for stochastic gravitational waves using data from the two colocated LIGO Hanford detectors

NASA Astrophysics Data System (ADS)

Aasi, J.; Abadie, J.; Abbott, B. P.; Abbott, R.; Abbott, T.; Abernathy, M. R.; Accadia, T.; Acernese, F.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Affeldt, C.; Agathos, M.; Aggarwal, N.; Aguiar, O. D.; Ajith, P.; Allen, B.; Allocca, A.; Amador Ceron, E.; Amariutei, D.; Anderson, R. A.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Araya, M. C.; Arceneaux, C.; Areeda, J.; Ast, S.; Aston, S. M.; Astone, P.; Aufmuth, P.; Aulbert, C.; Austin, L.; Aylott, B. E.; Babak, S.; Baker, P. T.; Ballardin, G.; Ballmer, S. W.; Barayoga, J. C.; Barker, D.; Barnum, S. H.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barton, M. A.; Bartos, I.; Bassiri, R.; Basti, A.; Batch, J.; Bauchrowitz, J.; Bauer, Th. S.; Bebronne, M.; Behnke, B.; Bejger, M.; Beker, M. G.; Bell, A. S.; Bell, C.; Belopolski, I.; Bergmann, G.; Berliner, J. M.; Bersanetti, D.; Bertolini, A.; Bessis, D.; Betzwieser, J.; Beyersdorf, P. T.; Bhadbhade, T.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Biscans, S.; Bitossi, M.; Bizouard, M. A.; Black, E.; Blackburn, J. K.; Blackburn, L.; Blair, D.; Blom, M.; Bock, O.; Bodiya, T. P.; Boer, M.; Bogan, C.; Bond, C.; Bondu, F.; Bonelli, L.; Bonnand, R.; Bork, R.; Born, M.; Boschi, V.; Bose, S.; Bosi, L.; Bowers, J.; Bradaschia, C.; Brady, P. R.; Braginsky, V. B.; Branchesi, M.; Brannen, C. A.; Brau, J. E.; Breyer, J.; Briant, T.; Bridges, D. O.; Brillet, A.; Brinkmann, M.; Brisson, V.; Britzger, M.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brückner, F.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Buskulic, D.; Buy, C.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Calderón Bustillo, J.; Calloni, E.; Camp, J. B.; Campsie, P.; Cannon, K. C.; Canuel, B.; Cao, J.; Capano, C. D.; Carbognani, F.; Carbone, L.; Caride, S.; Castiglia, A.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C.; Cesarini, E.; Chakraborty, R.; Chalermsongsak, T.; Chao, S.; Charlton, P.; Chassande-Mottin, E.; Chen, X.; Chen, Y.; Chincarini, A.; Chiummo, A.; Cho, H. S.; Chow, J.; Christensen, N.; Chu, Q.; Chua, S. S. Y.; Chung, S.; Ciani, G.; Clara, F.; Clark, D. E.; Clark, J. A.; Cleva, F.; Coccia, E.; Cohadon, P.-F.; Colla, A.; Colombini, M.; Constancio, M.; Conte, A.; Cook, D.; Corbitt, T. R.; Cordier, M.; Cornish, N.; Corsi, A.; Costa, C. A.; Coughlin, M. W.; Coulon, J.-P.; Countryman, S.; Couvares, P.; Coward, D. M.; Cowart, M.; Coyne, D. C.; Craig, K.; Creighton, J. D. E.; Creighton, T. D.; Crowder, S. G.; Cumming, A.; Cunningham, L.; Cuoco, E.; Dahl, K.; Dal Canton, T.; Damjanic, M.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dattilo, V.; Daudert, B.; Daveloza, H.; Davier, M.; Davies, G. S.; Daw, E. J.; Day, R.; Dayanga, T.; Debreczeni, G.; Degallaix, J.; Deleeuw, E.; Deléglise, S.; Del Pozzo, W.; Denker, T.; Dent, T.; Dereli, H.; Dergachev, V.; DeRosa, R. T.; De Rosa, R.; DeSalvo, R.; Dhurandhar, S.; Díaz, M.; Dietz, A.; Di Fiore, L.; Di Lieto, A.; Di Palma, I.; Di Virgilio, A.; Dmitry, K.; Donovan, F.; Dooley, K. L.; Doravari, S.; Drago, M.; Drever, R. W. P.; Driggers, J. C.; Du, Z.; Dumas, J.-C.; Dwyer, S.; Eberle, T.; Edwards, M.; Effler, A.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Endrőczi, G.; Essick, R.; Etzel, T.; Evans, K.; Evans, M.; Evans, T.; Factourovich, M.; Fafone, V.; Fairhurst, S.; Fang, Q.; Farr, B.; Farr, W.; Favata, M.; Fazi, D.; Fehrmann, H.; Feldbaum, D.; Ferrante, I.; Ferrini, F.; Fidecaro, F.; Finn, L. S.; Fiori, I.; Fisher, R.; Flaminio, R.; Foley, E.; Foley, S.; Forsi, E.; Fotopoulos, N.; Fournier, J.-D.; Franco, S.; Frasca, S.; Frasconi, F.; Frede, M.; Frei, M.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T. T.; Fritschel, P.; Frolov, V. V.; Fujimoto, M.-K.; Fulda, P.; Fyffe, M.; Gair, J.; Gammaitoni, L.; Garcia, J.; Garufi, F.; Gehrels, N.; Gemme, G.; Genin, E.; Gennai, A.; Gergely, L.; Ghosh, S.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Giazotto, A.; Gil-Casanova, S.; Gill, C.; Gleason, J.; Goetz, E.; Goetz, R.; Gondan, L.; González, G.; Gordon, N.; Gorodetsky, M. L.; Gossan, S.; Goßler, S.; Gouaty, R.; Graef, C.; Graff, P. B.; Granata, M.; Grant, A.; Gras, S.; Gray, C.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Griffo, C.; Grote, H.; Grover, K.; Grunewald, S.; Guidi, G. M.; Guido, C.; Gushwa, K. E.; Gustafson, E. K.; Gustafson, R.; Hall, B.; Hall, E.; Hammer, D.; Hammond, G.; Hanke, M.; Hanks, J.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G. M.; Harry, I. W.; Harstad, E. D.; Hartman, M. T.; Haughian, K.; Hayama, K.; Heefner, J.; Heidmann, A.; Heintze, M.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M.; Heng, I. S.; Heptonstall, A. W.; Heurs, M.; Hild, S.; Hoak, D.; Hodge, K. A.; Holt, K.; Hong, T.; Hooper, S.; Horrom, T.; Hosken, D. J.; Hough, J.; Howell, E. J.; Hu, Y.; Hua, Z.; Huang, V.; Huerta, E. A.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh, M.; Huynh-Dinh, T.; Iafrate, J.; Ingram, D. R.; Inta, R.; Isogai, T.; Ivanov, A.; Iyer, B. R.; Izumi, K.; Jacobson, M.; James, E.; Jang, H.; Jang, Y. J.; Jaranowski, P.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, D.; Jones, R.; Jonker, R. J. G.; Ju, L.; Haris, K.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kasprzack, M.; Kasturi, R.; Katsavounidis, E.; Katzman, W.; Kaufer, H.; Kaufman, K.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kéfélian, F.; Keitel, D.; Kelley, D. B.; Kells, W.; Keppel, D. G.; Khalaidovski, A.; Khalili, F. Y.; Khazanov, E. A.; Kim, B. K.; Kim, C.; Kim, K.; Kim, N.; Kim, W.; Kim, Y.-M.; King, E.; King, P. J.; Kinzel, D. L.; Kissel, J. S.; Klimenko, S.; Kline, J.; Koehlenbeck, S.; Kokeyama, K.; Kondrashov, V.; Koranda, S.; Korth, W. Z.; Kowalska, I.; Kozak, D.; Kremin, A.; Kringel, V.; Krishnan, B.; Królak, A.; Kucharczyk, C.; Kudla, S.; Kuehn, G.; Kumar, A.; Kumar, D. Nanda; Kumar, P.; Kumar, R.; Kurdyumov, R.; Kwee, P.; Landry, M.; Lantz, B.; Larson, S.; Lasky, P. D.; Lawrie, C.; Lazzarini, A.; Leaci, P.; Lebigot, E. O.; Lee, C.-H.; Lee, H. K.; Lee, H. M.; Lee, J. J.; Lee, J.; Leonardi, M.; Leong, J. R.; Le Roux, A.; Leroy, N.; Letendre, N.; Levine, B.; Lewis, J. B.; Lhuillier, V.; Li, T. G. F.; Lin, A. C.; Littenberg, T. B.; Litvine, V.; Liu, F.; Liu, H.; Liu, Y.; Liu, Z.; Lloyd, D.; Lockerbie, N. A.; Lockett, V.; Lodhia, D.; Loew, K.; Logue, J.; Lombardi, A. L.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J.; Luan, J.; Lubinski, M. J.; Lück, H.; Lundgren, A. P.; Macarthur, J.; Macdonald, E.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magana-Sandoval, F.; Mageswaran, M.; Mailand, K.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Manca, G. M.; Mandel, I.; Mandic, V.; Mangano, V.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markosyan, A.; Maros, E.; Marque, J.; Martelli, F.; Martellini, L.; Martin, I. W.; Martin, R. M.; Martini, G.; Martynov, D.; Marx, J. N.; Mason, K.; Masserot, A.; Massinger, T. J.; Matichard, F.; Matone, L.; Matzner, R. A.; Mavalvala, N.; May, G.; Mazumder, N.; Mazzolo, G.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McIntyre, G.; McIver, J.; Meacher, D.; Meadors, G. D.; Mehmet, M.; Meidam, J.; Meier, T.; Melatos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyer, M. S.; Miao, H.; Michel, C.; Mikhailov, E.; Milano, L.; Miller, J.; Minenkov, Y.; Mingarelli, C. M. F.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moe, B.; Mohan, M.; Mohapatra, S. R. P.; Mokler, F.; Moraru, D.; Moreno, G.; Morgado, N.; Mori, T.; Morriss, S. R.; Mossavi, K.; Mours, B.; Mow-Lowry, C. M.; Mueller, C. L.; Mueller, G.; Mukherjee, S.; Mullavey, A.; Munch, J.; Murphy, D.; Murray, P. G.; Mytidis, A.; Nagy, M. F.; Nardecchia, I.; Nash, T.; Naticchioni, L.; Nayak, R.; Necula, V.; Neri, I.; Neri, M.; Newton, G.; Nguyen, T.; Nishida, E.; Nishizawa, A.; Nitz, A.; Nocera, F.; Nolting, D.; Normandin, M. E.; Nuttall, L. K.; Ochsner, E.; O'Dell, J.; Oelker, E.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Oppermann, P.; O'Reilly, B.; Ortega Larcher, W.; O'Shaughnessy, R.; Osthelder, C.; Ottaway, D. J.; Ottens, R. S.; Ou, J.; Overmier, H.; Owen, B. J.; Padilla, C.; Pai, A.; Palomba, C.; Pan, Y.; Pankow, C.; Paoletti, F.; Paoletti, R.; Paris, H.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Pedraza, M.; Peiris, P.; Penn, S.; Perreca, A.; Phelps, M.; Pichot, M.; Pickenpack, M.; Piergiovanni, F.; Pierro, V.; Pinard, L.; Pindor, B.; Pinto, I. M.; Pitkin, M.; Poeld, J.; Poggiani, R.; Poole, V.; Postiglione, F.; Poux, C.; Predoi, V.; Prestegard, T.; Price, L. R.; Prijatelj, M.; Privitera, S.; Prodi, G. A.; Prokhorov, L.; Puncken, O.; Punturo, M.; Puppo, P.; Quetschke, V.; Quintero, E.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Rácz, I.; Radkins, H.; Raffai, P.; Raja, S.; Rajalakshmi, G.; Rakhmanov, M.; Ramet, C.; Rapagnani, P.; Raymond, V.; Re, V.; Reed, C. M.; Reed, T.; Regimbau, T.; Reid, S.; Reitze, D. H.; Ricci, F.; Riesen, R.; Riles, K.; Robertson, N. A.; Robinet, F.; Rocchi, A.; Roddy, S.; Rodriguez, C.; Rodruck, M.; Roever, C.; Rolland, L.; Rollins, J. G.; Romano, J. D.; Romano, R.; Romanov, G.; Romie, J. H.; Rosińska, D.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Ryan, K.; Salemi, F.; Sammut, L.; Sandberg, V.; Sanders, J.; Sannibale, V.; Santiago-Prieto, I.; Saracco, E.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Savage, R.; Schilling, R.; Schnabel, R.; Schofield, R. M. S.; Schreiber, E.; Schuette, D.; Schulz, B.; Schutz, B. F.; Schwinberg, P.; Scott, J.; Scott, S. M.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Sentenac, D.; Sequino, V.; Sergeev, A.; Shaddock, D.; Shah, S.; Shahriar, M. S.; Shaltev, M.; Shapiro, B.; Shawhan, P.; Shoemaker, D. H.; Sidery, T. L.; Siellez, K.; Siemens, X.; Sigg, D.; Simakov, D.; Singer, A.; Singer, L.; Sintes, A. M.; Skelton, G. R.; Slagmolen, B. J. J.; Slutsky, J.; Smith, J. R.; Smith, M. R.; Smith, R. J. E.; Smith-Lefebvre, N. D.; Soden, K.; Son, E. J.; Sorazu, B.; Souradeep, T.; Sperandio, L.; Staley, A.; Steinert, E.; Steinlechner, J.; Steinlechner, S.; Steplewski, S.; Stevens, D.; Stochino, A.; Stone, R.; Strain, K. A.; Straniero, N.; Strigin, S.; Stroeer, A. S.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Susmithan, S.; Sutton, P. J.; Swinkels, B.; Szeifert, G.; Tacca, M.; Talukder, D.; Tang, L.; Tanner, D. B.; Tarabrin, S. P.; Taylor, R.; ter Braack, A. P. M.; Thirugnanasambandam, M. P.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Tiwari, V.; Tokmakov, K. V.; Tomlinson, C.; Toncelli, A.; Tonelli, M.; Torre, O.; Torres, C. V.; Torrie, C. I.; Travasso, F.; Traylor, G.; Tse, M.; Ugolini, D.; Unnikrishnan, C. S.; Vahlbruch, H.; Vajente, G.; Vallisneri, M.; van den Brand, J. F. J.; Van Den Broeck, C.; van der Putten, S.; van der Sluys, M. V.; van Heijningen, J.; van Veggel, A. A.; Vass, S.; Vasúth, M.; Vaulin, R.; Vecchio, A.; Vedovato, G.; Veitch, P. J.; Veitch, J.; Venkateswara, K.; Verkindt, D.; Verma, S.; Vetrano, F.; Viceré, A.; Vincent-Finley, R.; Vinet, J.-Y.; Vitale, S.; Vitale, S.; Vlcek, B.; Vo, T.; Vocca, H.; Vorvick, C.; Vousden, W. D.; Vrinceanu, D.; Vyachanin, S. P.; Wade, A.; Wade, L.; Wade, M.; Waldman, S. J.; Walker, M.; Wallace, L.; Wan, Y.; Wang, J.; Wang, M.; Wang, X.; Wanner, A.; Ward, R. L.; Was, M.; Weaver, B.; Wei, L.-W.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Welborn, T.; Wen, L.; Wessels, P.; West, M.; Westphal, T.; Wette, K.; Whelan, J. T.; White, D. J.; Whiting, B. F.; Wibowo, S.; Wiesner, K.; Wilkinson, C.; Williams, L.; Williams, R.; Williams, T.; Willis, J. L.; Willke, B.; Wimmer, M.; Winkelmann, L.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Worden, J.; Yablon, J.; Yakushin, I.; Yamamoto, H.; Yancey, C. C.; Yang, H.; Yeaton-Massey, D.; Yoshida, S.; Yum, H.; Yvert, M.; ZadroŻny, A.; Zanolin, M.; Zendri, J.-P.; Zhang, F.; Zhang, L.; Zhao, C.; Zhu, H.; Zhu, X. J.; Zotov, N.; Zucker, M. E.; Zweizig, J.; LIGO Scientific Collaboration; Virgo Collaboration

2015-01-01

Searches for a stochastic gravitational-wave background (SGWB) using terrestrial detectors typically involve cross-correlating data from pairs of detectors. The sensitivity of such cross-correlation analyses depends, among other things, on the separation between the two detectors: the smaller the separation, the better the sensitivity. Hence, a colocated detector pair is more sensitive to a gravitational-wave background than a noncolocated detector pair. However, colocated detectors are also expected to suffer from correlated noise from instrumental and environmental effects that could contaminate the measurement of the background. Hence, methods to identify and mitigate the effects of correlated noise are necessary to achieve the potential increase in sensitivity of colocated detectors. Here we report on the first SGWB analysis using the two LIGO Hanford detectors and address the complications arising from correlated environmental noise. We apply correlated noise identification and mitigation techniques to data taken by the two LIGO Hanford detectors, H1 and H2, during LIGO's fifth science run. At low frequencies, 40-460 Hz, we are unable to sufficiently mitigate the correlated noise to a level where we may confidently measure or bound the stochastic gravitational-wave signal. However, at high frequencies, 460-1000 Hz, these techniques are sufficient to set a 95% confidence level upper limit on the gravitational-wave energy density of Ω (f )<7.7 ×1 0-4(f /900 Hz )3 , which improves on the previous upper limit by a factor of ˜180 . In doing so, we demonstrate techniques that will be useful for future searches using advanced detectors, where correlated noise (e.g., from global magnetic fields) may affect even widely separated detectors.

Searching for Stochastic Gravitational Waves Using Data from the Two Co-Located LIGO Hanford Detectors

NASA Technical Reports Server (NTRS)

Aasi, J.; Abadie, J.; Abbott, B. P.; Abbott, R.; Abbott, T.; Abernathy, M. R.; Accadia, T.; Acernese, F.; Adams, C.; Adams, T.;

The effects of transboundary air pollution following major events in China on air quality in the U.S.: Evidence from Chinese New Year and sandstorms.

PubMed

Ngo, N S; Zhong, N; Bao, X

2018-04-15

Transboundary air pollution is a global environmental and public health problem including in the U.S., where pollution emissions from China, the largest emitter of anthropogenic air pollution in the world, can travel across the Pacific Ocean and reach places like California and Oregon. We examine the effects of transboundary air pollution following major events in China, specifically sandstorms, a natural-occurring source of air pollution, and Chinese New Year, a major 7-day holiday, on background air quality in the U.S. We focus on high elevation sites on the west coast between 2000 and 2013. We use regression analysis and a natural experiment to exploit the variation in the timing of these events in China, which are plausibly uncorrelated to other factors that affect air quality in China and the U.S. We find that sandstorms are associated with statistically significant increases in background coarse and fine particulate matter (PM) in the U.S., representing between 16 and 39% of average weekly PM levels. We also find Chinese New Year is associated with modest reductions in background air quality in the U.S., representing between 0.4 and 2.5% of PM levels. Findings are robust to different models and falsification tests. These results suggest that regression analysis could be a powerful tool to complement other, more widely used techniques in the environmental sciences that study this problem. This also has important implications for policymakers, who could track major sandstorms in China and prepare for possible increased foreign pollution emissions in the U.S. Copyright © 2018 Elsevier Ltd. All rights reserved.

Sea level change since 2005: importance of salinity

NASA Astrophysics Data System (ADS)

Llovel, W.; Purkey, S.; Meyssignac, B.; Kolodziejczyk, N.; Blazquez, A.; Bamber, J. L.

2017-12-01

Sea level rise is one of the most important consequences of the actual global warming. Global mean sea level has been rising at a faster rate since 1993 (over the satellite altimetry era) than previous decades. This rise is expected to accelerate over the coming decades and century. At global scale, sea level rise is caused by a combination of freshwater increase from land ice melting and land water changes (mass component) and ocean warming (thermal expansion). Estimating the causes is of great interest not only to understand the past sea level changes but also to validate projections based on climate models. In this study, we investigate the global mass contribution to recent sea level changes with an alternative approach by estimating the global ocean freshening. For that purpose, we consider the unprecedented amount of salinity measurements from Argo floats for the past decade (2005-2015). We compare our results to the ocean mass inferred by GRACE data and based on a sea level budget approach. Our results bring new constrains on the global water cycle (ocean freshening) and energy budget (ocean warming) as well as on the global ocean mass directly inferred from GRACE data.

Impact of iodine chemistry on coastal ozone levels at the Gulf of Mexico

NASA Astrophysics Data System (ADS)

Tuite, K.; Stutz, J.; Brockway, N.; Colosimo, S. F.; Tsai, J. Y.; Grossmann, K.; Alvarez, S. L.; Flynn, J. H., III; Erickson, M.; Caicedo, V.; Griffin, R. J.; Wallace, H. W., IV; Schulze, B.; Sheesley, R. J.; Usenko, S.; Yarwood, G.; Nopmongcol, U.

2016-12-01

Reactive iodine (Ix = I + IO) is known to destroy ozone through catalytic cycles in the marine boundary layer (MBL) and can thus have a significant impact on tropospheric ozone in coastal regions. As air quality standards for ozone become stricter, accurate background levels are increasingly important for the development of ozone reduction strategies. The Texas Gulf coast is an example for the significance of MBL background ozone, as onshore flows from the Gulf of Mexico contribute to the ozone levels in Houston and other coastal areas. The Gulf coast often experiences ozone mixing ratios below 20 ppb during summer onshore flow conditions, which are currently overestimated by regional and global air quality models. Modeling with the Comprehensive Air quality Model with extensions (CAMx) and GEOS-Chem including halogen chemistry identified iodine emissions from the Gulf of Mexico as a possible explanation. However, ambient measurements of Ix species for the Gulf of Mexico are needed to test this hypothesis and, if confirmed, refine models. We measured IO, O3, and other trace gases at the Gulf coast near Galveston, TX, using UCLA's long path DOAS instrument and a suite of in-situ instruments. During the study period from May 15 through July 12, 2016, several multi-day events with MBL ozone levels below 20 ppb were encountered. Here we present the observational data with a focus on time periods with onshore flow from the Gulf. A chemical steady state analysis will be used to assess whether the observed Ix mixing ratios can explain these low ozone mixing ratios. Our results will be compared to the CAMx and GEOS-Chem model simulations.

Short educational programs in optical design and engineering

NASA Astrophysics Data System (ADS)

Voznesenskaya, Anna; Romanova, Galina; Bakholdin, Alexey; Tolstoba, Nadezhda; Ezhova, Kseniia

2016-09-01

Globalization and diversification of education in optical engineering causes a number of new phenomena in students' learning paths. Many students have an interest to get some courses in other universities, to study in international environment, to broaden not only professional skills but social links and see the sights as well etc. Participation in short educational programs (e.g. summer / winter schools, camps etc.) allows students from different universities to learn specific issues in their or in some neighbor field and also earn some ECTS for the transcript of records. ITMO University provides a variety of short educational programs in optical design and engineering oriented for different background level, such are: Introduction into optical engineering, Introduction into applied and computer optics, Optical system design, Image modeling and processing, Design of optical devices and components. Depending on students' educational background these programs are revised and adopted each time. Usually the short educational programs last 4 weeks and provide 4 ECTS. The short programs utilize a set of out-of date educational technologies like problem-based learning, case-study and distance-learning and evaluation. Practically, these technologies provide flexibility of the educational process and intensive growth of the learning outcomes. Students are satisfied with these programs very much. In their feedbacks they point a high level of practical significance, experienced teaching staff, scholarship program, excellent educational environment, as well as interesting social program and organizational support.

Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome

PubMed Central

Xue, Peng; Hou, Yongyong; Chen, Yanyan; Yang, Bei; Fu, Jingqi; Zheng, Hongzhi; Yarborough, Kathy; Woods, Courtney G.; Liu, Dianxin; Yamamoto, Masayuki; Zhang, Qiang; Andersen, Melvin E.; Pi, Jingbo

2013-01-01

Nuclear factor E2–related factor 2 (Nrf2) is a transcription factor that functions as a master regulator of the cellular adaptive response to oxidative stress. Our previous studies showed that Nrf2 plays a critical role in adipogenesis by regulating expression of CCAAT/enhancer-binding protein β and peroxisome proliferator–activated receptor γ. To determine the role of Nrf2 in the development of obesity and associated metabolic disorders, the incidence of metabolic syndrome was assessed in whole-body or adipocyte-specific Nrf2-knockout mice on a leptin-deficient ob/ob background, a model with an extremely positive energy balance. On the ob/ob background, ablation of Nrf2, globally or specifically in adipocytes, led to reduced white adipose tissue (WAT) mass, but resulted in an even more severe metabolic syndrome with aggravated insulin resistance, hyperglycemia, and hypertriglyceridemia. Compared with wild-type mice, WAT of ob/ob mice expressed substantially higher levels of many genes related to antioxidant response, inflammation, adipogenesis, lipogenesis, glucose uptake, and lipid transport. Absence of Nrf2 in WAT resulted in reduced expression of most of these factors at mRNA or protein levels. Our findings support a novel role for Nrf2 in regulating adipose development and function, by which Nrf2 controls the capacity of WAT expansion and insulin sensitivity and maintains glucose and lipid homeostasis. PMID:23238296

Consensus–based approach to develop a measurement framework and identify a core set of indicators to track implementation and progress towards effective coverage of facility–based Kangaroo Mother Care

PubMed Central

Guenther, Tanya; Moxon, Sarah; Valsangkar, Bina; Wetzel, Greta; Ruiz, Juan; Kerber, Kate; Blencowe, Hannah; Dube, Queen; Vani, Shashi N; Vivio, Donna; Magge, Hema; De Leon–Mendoza, Socorro; Patterson, Janna; Mazia, Goldy

2017-01-01

Background As efforts to scale up the delivery of Kangaroo Mother Care (KMC) in facilities are increasing, a standardized approach to measure implementation and progress towards effective coverage is needed. Here, we describe a consensus–based approach to develop a measurement framework and identify a core set of indicators for monitoring facility–based KMC that would be feasible to measure within existing systems. Methods The KMC measurement framework and core list of indicators were developed through: 1) scoping exercise to identify potential indicators through literature review and requests from researchers and program implementers; and 2) face–to–face consultations with KMC and measurement experts working at country and global levels to review candidate indicators and finalize selection and definitions. Results The KMC measurement framework includes two main components: 1) service readiness, based on the WHO building blocks framework; and 2) service delivery action sequence covering identification, service initiation, continuation to discharge, and follow–up to graduation. Consensus was reached on 10 core indicators for KMC, which were organized according to the measurement framework. We identified 4 service readiness indicators, capturing national level policy for KMC, availability of KMC indicators in HMIS, costed operational plans for KMC and availability of KMC services at health facilities with inpatient maternity services. Six indicators were defined for service delivery, including weighing of babies at birth, identification of those ≤2000 g, initiation of facility–based KMC, monitoring the quality of KMC, status of babies at discharge from the facility and levels of follow–up (according to country–specific protocol). Conclusions These core KMC indicators, identified with input from a wide range of global and country–level KMC and measurement experts, can aid efforts to strengthen monitoring systems and facilitate global tracking of KMC implementation. As data collection systems advance, we encourage program managers and evaluators to document their experiences using this framework to measure progress and allow indicator refinement, with the overall aim of working towards sustainable, country–led data systems. PMID:29057074

How Are New Vaccines Prioritized in Low-Income Countries? A Case Study of Human Papilloma Virus Vaccine and Pneumococcal Conjugate Vaccine in Uganda

PubMed Central

Wallace, Lauren; Kapirir, Lydia

2017-01-01

Background: To date, research on priority-setting for new vaccines has not adequately explored the influence of the global, national and sub-national levels of decision-making or contextual issues such as political pressure and stakeholder influence and power. Using Kapiriri and Martin’s conceptual framework, this paper evaluates priority setting for new vaccines in Uganda at national and sub-national levels, and considers how global priorities can influence country priorities. This study focuses on 2 specific vaccines, the human papilloma virus (HPV) vaccine and the pneumococcal conjugate vaccine (PCV). Methods: This was a qualitative study that involved reviewing relevant Ugandan policy documents and media reports, as well as 54 key informant interviews at the global level and national and sub-national levels in Uganda. Kapiriri and Martin’s conceptual framework was used to evaluate the prioritization process. Results: Priority setting for PCV and HPV was conducted by the Ministry of Health (MoH), which is considered to be a legitimate institution. While respondents described the priority setting process for PCV process as transparent, participatory, and guided by explicit relevant criteria and evidence, the prioritization of HPV was thought to have been less transparent and less participatory. Respondents reported that neither process was based on an explicit priority setting framework nor did it involve adequate representation from the districts (program implementers) or publicity. The priority setting process for both PCV and HPV was negatively affected by the larger political and economic context, which contributed to weak institutional capacity as well as power imbalances between development assistance partners and the MoH. Conclusion: Priority setting in Uganda would be improved by strengthening institutional capacity and leadership and ensuring a transparent and participatory processes in which key stakeholders such as program implementers (the districts) and beneficiaries (the public) are involved. Kapiriri and Martin’s framework has the potential to guide priority setting evaluation efforts, however, evaluation should be built into the priority setting process a priori such that information on priority setting is gathered throughout the implementation cycle. PMID:29172378

Strategies for rapid global earthquake impact estimation: the Prompt Assessment of Global Earthquakes for Response (PAGER) system

USGS Publications Warehouse

Jaiswal, Kishor; Wald, D.J.

2013-01-01

This chapter summarizes the state-of-the-art for rapid earthquake impact estimation. It details the needs and challenges associated with quick estimation of earthquake losses following global earthquakes, and provides a brief literature review of various approaches that have been used in the past. With this background, the chapter introduces the operational earthquake loss estimation system developed by the U.S. Geological Survey (USGS) known as PAGER (for Prompt Assessment of Global Earthquakes for Response). It also details some of the ongoing developments of PAGER’s loss estimation models to better supplement the operational empirical models, and to produce value-added web content for a variety of PAGER users.

Globalization and human cooperation.

PubMed

Buchan, Nancy R; Grimalda, Gianluca; Wilson, Rick; Brewer, Marilynn; Fatas, Enrique; Foddy, Margaret

2009-03-17

Globalization magnifies the problems that affect all people and that require large-scale human cooperation, for example, the overharvesting of natural resources and human-induced global warming. However, what does globalization imply for the cooperation needed to address such global social dilemmas? Two competing hypotheses are offered. One hypothesis is that globalization prompts reactionary movements that reinforce parochial distinctions among people. Large-scale cooperation then focuses on favoring one's own ethnic, racial, or language group. The alternative hypothesis suggests that globalization strengthens cosmopolitan attitudes by weakening the relevance of ethnicity, locality, or nationhood as sources of identification. In essence, globalization, the increasing interconnectedness of people worldwide, broadens the group boundaries within which individuals perceive they belong. We test these hypotheses by measuring globalization at both the country and individual levels and analyzing the relationship between globalization and individual cooperation with distal others in multilevel sequential cooperation experiments in which players can contribute to individual, local, and/or global accounts. Our samples were drawn from the general populations of the United States, Italy, Russia, Argentina, South Africa, and Iran. We find that as country and individual levels of globalization increase, so too does individual cooperation at the global level vis-à-vis the local level. In essence, "globalized" individuals draw broader group boundaries than others, eschewing parochial motivations in favor of cosmopolitan ones. Globalization may thus be fundamental in shaping contemporary large-scale cooperation and may be a positive force toward the provision of global public goods.

Adaptation to Leftward-Shifting Prisms Reduces the Global Processing Bias of Healthy Individuals

ERIC Educational Resources Information Center

Bultitude, Janet H.; Woods, Jill M.

2010-01-01

When healthy individuals are presented with peripheral figures in which small letters are arranged to form a large letter, they are faster to identify the global- than the local-level information, and have difficulty ignoring global information when identifying the local level. The global reaction time (RT) advantage and global interference effect…

The politics of agenda setting at the global level: key informant interviews regarding the International Labour Organization Decent Work Agenda

PubMed Central

2014-01-01

Background Global labour markets continue to undergo significant transformations resulting from socio-political instability combined with rises in structural inequality, employment insecurity, and poor working conditions. Confronted by these challenges, global institutions are providing policy guidance to protect and promote the health and well-being of workers. This article provides an account of how the International Labour Organization’s Decent Work Agenda contributes to the work policy agendas of the World Health Organization and the World Bank. Methods This qualitative study involved semi-structured interviews with representatives from three global institutions – the International Labour Organization (ILO), the World Health Organization and the World Bank. Of the 25 key informants invited to participate, 16 took part in the study. Analysis for key themes was followed by interpretation using selected agenda setting theories. Results Interviews indicated that through the Decent Work Agenda, the International Labour Organization is shaping the global policy narrative about work among UN agencies, and that the pursuit of decent work and the Agenda were perceived as important goals with the potential to promote just policies. The Agenda was closely linked to the World Health Organization’s conception of health as a human right. However, decent work was consistently identified by World Bank informants as ILO terminology in contrast to terms such as job creation and job access. The limited evidence base and its conceptual nature were offered as partial explanations for why the Agenda has yet to fully influence other global institutions. Catalytic events such as the economic crisis were identified as creating the enabling conditions to influence global work policy agendas. Conclusions Our evidence aids our understanding of how an issue like decent work enters and stays on the policy agendas of global institutions, using the Decent Work Agenda as an illustrative example. Catalytic events and policy precedents were found to contribute positively to agenda setting. Questions remain, however, across key informants about the robustness of the underlying evidence base for this Agenda and what meaningful impacts have been realized on the ground as a result. PMID:24986161

Peritoneal Dialysate Glucose Load and Systemic Glucose Metabolism in Non-Diabetics: Results from the GLOBAL Fluid Cohort Study

PubMed Central

Chess, James; Do, Jun-Young; Noh, Hyunjin; Lee, Hi-Bahl; Kim, Yong-Lim; Summers, Angela; Williams, Paul Ford; Davison, Sara; Dorval, Marc

2016-01-01

Background and Objectives Glucose control is a significant predictor of mortality in diabetic peritoneal dialysis (PD) patients. During PD, the local toxic effects of intra-peritoneal glucose are well recognized, but despite large amounts of glucose being absorbed, the systemic effects of this in non-diabetic patients are not clear. We sought to clarify whether dialysate glucose has an effect upon systemic glucose metabolism. Methods and Materials We analysed the Global Fluid Study cohort, a prospective, observational cohort study initiated in 2002. A subset of 10 centres from 3 countries with high data quality were selected (368 incident and 272 prevalent non-diabetic patients), with multilevel, multivariable analysis of the reciprocal of random glucose levels, and a stratified-by-centre Cox survival analysis. Results The median follow up was 5.6 and 6.4 years respectively in incident and prevalent patients. On multivariate analysis, serum glucose increased with age (β = -0.007, 95%CI -0.010, -0.004) and decreased with higher serum sodium (β = 0.002, 95%CI 0.0005, 0.003) in incident patients and increased with dialysate glucose (β = -0.0002, 95%CI -0.0004, -0.00006) in prevalent patients. Levels suggested undiagnosed diabetes in 5.4% of prevalent patients. Glucose levels predicted death in unadjusted analyses of both incident and prevalent groups but in an adjusted survival analysis they did not (for random glucose 6–10 compared with <6, Incident group HR 0.92, 95%CI 0.58, 1.46, Prevalent group HR 1.42, 95%CI 0.86, 2.34). Conclusions In prevalent non-diabetic patients, random glucose levels at a diabetic level are under-recognised and increase with dialysate glucose load. Random glucose levels predict mortality in unadjusted analyses, but this association has not been proven in adjusted analyses. PMID:27249020

Open access tools for quality-assured and efficient data entry in a large, state-wide tobacco survey in India

PubMed Central

Shewade, Hemant Deepak; Vidhubala, E; Subramani, Divyaraj Prabhakar; Lal, Pranay; Bhatt, Neelam; Sundaramoorthi, C.; Singh, Rana J.; Kumar, Ajay M. V.

2017-01-01

ABSTRACT Background: A large state-wide tobacco survey was conducted using modified version of pretested, globally validated Global Adult Tobacco Survey (GATS) questionnaire in 2015–22016 in Tamil Nadu, India. Due to resource constrains, data collection was carrid out using paper-based questionnaires (unlike the GATS-India, 2009–2010, which used hand-held computer devices) while data entry was done using open access tools. The objective of this paper is to describe the process of data entry and assess its quality assurance and efficiency. Methods: In EpiData language, a variable is referred to as ‘field’ and a questionnaire (set of fields) as ‘record’. EpiData software was used for double data entry with adequate checks followed by validation. Teamviewer was used for remote training and trouble shooting. The EpiData databases (one each for each district and each zone in Chennai city) were housed in shared Dropbox folders, which enabled secure sharing of files and automatic back-up. Each database for a district/zone had separate file for data entry of household level and individual level questionnaire. Results: Of 32,945 households, there were 111,363 individuals aged ≥15 years. The average proportion of records with data entry errors for a district/zone in household level and individual level file was 4% and 24%, respectively. These are the errors that would have gone unnoticed if single entry was used. The median (inter-quartile range) time taken for double data entry for a single household level and individual level questionnaire was 30 (24, 40) s and 86 (64, 126) s, respectively. Conclusion: Efficient and quality-assured near-real-time data entry in a large sub-national tobacco survey was performed using innovative, resource-efficient use of open access tools. PMID:29092673

UPDATE ON THE GLOBAL BURDEN OF ISCHAEMIC AND HAEMORRHAGIC STROKE IN 1990–2013: THE GBD 2013 STUDY

PubMed Central

Feigin, Valery L.; Krishnamurthi, Rita; Parmar, Priya; Norrving, Bo; Mensah, George A.; Bennett, Derrick A.; Barker-Collo, Suzanne; Moran, Andrew; Sacco, Ralph L.; Truelsen, Thomas; Davis, Stephen; Pandian, Jeyaraj Durai; Naghavi, Mohsen; Forouzanfar, Mohammad H.; Nguyen, Grant; Johnson, Catherine O.; Vos, Theo; Meretoja, Atte; Murray, Christopher; Roth, Gregory A.; Thrift, Amanda; Banerjee, Amitava; Kengne, Andre Pascal; Misganaw, Awoke; Kissela, Brett M.; Wolfe, Charles; Yu, Chuanhua; Anderson, Craig; Kim, Daniel; Rojas-Rueda, David; Tanne, David; Tirschwell, David Lawrence; Nand, Devina; Kazi, Dhruv S.; Pourmalek, Farshad; Catalá-López, Ferrán; Abd-Allah, Foad; Gankpé, Fortuné; deVeber, Gabrielle; Donnan, Geoffrey; Hankey, Graeme J.; Christensen, Hanne K.; Campos-Nonato, Ismael; Shiue, Ivy; Fernandes, Jefferson G.; Jonas, Jost B.; Sheth, Kevin; Kim, Yunjin; Dokova, Klara; Stroumpoulis, Konstantinos; Sposato, Luciano A.; Bahit, Maria Cecilia; Geleijnse, Johanna M.; Mackay, Mark T.; Mehndiratta, Man Mohan; Endres, Matthias; Giroud, Maurice; Brainin, Michael; Kravchenko, Michael; Piradov, Michael; Soljak, Michael; Liu, Ming; Connor, Myles; Venketasubramanian, Narayanaswamy; Bornstein, Natan; Shamalov, Nikolay; Roy, Nobhojit; Cabral, Norberto; Beauchamp, Norman J.; Lavados, Pablo M.; Jeemon, Panniyammakal; Lotufo, Paulo A.; Chowdhury, Rajiv; Sahathevan, Ramesh; Hamadeh, Randah R.; Malekzadeh, Reza; Gillium, Richard; Westerman, Ronny; Akinyemi, Rufus Olusola; Salman, Rustam Al-Shahi; Dharmaratne, Samath D.; Basu, Sanjay; Abera, Semaw Ferede; Kosen, Soewarta; Sampson, Uchechukwu K. A.; Caso, Valeria; Vlassov, Vasiliy; Melaku, Yohannes Adama; Kokubo, Yoshiohiro; Shinohara, Yukito; Varakin, Yuri; Wang, Wenzhi

2015-01-01

Background Global stroke epidemiology is changing rapidly. Although age-standardised rates of stroke mortality have decreased worldwide in the past two decades, the absolute numbers of people who have a stroke every year, live with the consequences of stroke, and die from their stroke are increasing. Regular updates on the current level of stroke burden are important for advancing our knowledge on stroke epidemiology and facilitate organization and planning of evidence-based stroke care. Objectives To estimate incidence, prevalence, mortality, disability-adjusted life-years (DALYs) and years lived with disability (YLDs), and their trends for ischaemic stroke (IS) and haemorrhagic stroke (HS) for 188 countries from 1990–2013. Methodology Stroke incidence, prevalence, mortality, DALYs and YLDs were estimated using all available data on mortality and stroke incidence, prevalence and excess mortality. Statistical models and country-level covariate data were employed and all rates were age-standardised to a global population. All estimated were produced with 95% uncertainty intervals (UI). Results In 2013, there were globally almost 25.7 million stroke survivors (71% with IS), 6.5 million deaths from stroke (51% died from IS), 113 million DALYs due to stroke (58% due to IS), and 10.3 million new strokes (67% IS). Over the 1990–2013 period, there was a significant increase in the absolute number of DALYs due to IS, and of deaths from IS and HS, survivors and incident events for both IS and HS. The preponderance of the burden of stroke continued to reside in developing countries, comprising 75.2% of deaths from stroke and 81.0% of stroke-related DALYs. Globally, the proportional contribution of stroke-related DALYs and deaths due to stroke compared to all diseases increased from 1990 (3.54% [95% UI 3.11–4.00%] and 9.66% [95% UI 8.47–10.70%]) to 2013 (4.62% [95% UI 4.01–5.30%] and 11.75% [95% UI 10.45–13.31%], respectively), but there was a diverging trend in developed and developing countries with a significant increase in DALYs and deaths in developing countries, and no measurable change in the proportional contribution of DALYs and deaths from stroke in developed countries. Conclusion Global stroke burden continues to increase globally. More efficient stroke prevention and management strategies are urgently needed to halt and eventually reverse the stroke pandemic, while universal access to organized stroke services should be a priority. PMID:26505981

"We Know What to Say, We Know What to Write, but We Don't Know How": The Challenges of Becoming Academically Literate in a New Linguistic and Socio-Cultural Space

ERIC Educational Resources Information Center

Sibomana, Emmanuel

2016-01-01

Historically, some languages and discourses which were initially localised subsequently became regionally or even globally dominant. Currently, English is the dominant global language in all domains, including the academic. Thus academics and scholars from non-English backgrounds are at a disadvantage: they have to adhere to academic literacy…

Global Surveillance of Emerging Influenza Virus Genotypes by Mass Spectrometry

DTIC Science & Technology

2007-05-30

Intercontinental circulation of human influenza A( H1N2 ) reassortant viruses during the 2001–2002 influenza season. J Infect Dis 186: 1490–1493. 6. Taubenberger...Global Surveillance of Emerging Influenza Virus Genotypes by Mass Spectrometry Rangarajan Sampath1*, Kevin L. Russell2, Christian Massire1, Mark W...Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America Background. Effective influenza surveillance requires

Global atmospheric emissions and transport of polycyclic aromatic hydrocarbons: Evaluation of modeling and transboundary pollution

NASA Astrophysics Data System (ADS)

Shen, Huizhong; Tao, Shu

2014-05-01

Global atmospheric emissions of 16 polycyclic aromatic hydrocarbons (PAHs) from 69 major sources were estimated for a period from 1960 to 2030. Regression models and a technology split method were used to estimated country and time specific emission factors, resulting in a new estimate of PAH emission factor variation among different countries and over time. PAH emissions in 2007 were spatially resolved to 0.1° × 0.1° grids based on a newly developed global high-resolution fuel combustion inventory (PKU-FUEL-2007). MOZART-4 (The Model for Ozone and Related Chemical Tracers, version 4) was applied to simulate the global tropospheric transport of Benzo(a)pyrene, one of the high molecular weight carcinogenic PAHs, at a horizontal resolution of 1.875° (longitude) × 1.8947° (latitude). The reaction with OH radical, gas/particle partitioning, wet deposition, dry deposition, and dynamic soil/ocean-air exchange of PAHs were considered. The simulation was validated by observations at both background and non-background sites, including Alert site in Canadian High Arctic, EMEP sites in Europe, and other 254 urban/rural sites reported from literatures. Key factors effecting long-range transport of BaP were addressed, and transboundary pollution was discussed.

Impaired visual recognition of biological motion in schizophrenia.

PubMed

Kim, Jejoong; Doop, Mikisha L; Blake, Randolph; Park, Sohee

2005-09-15

Motion perception deficits have been suggested to be an important feature of schizophrenia but the behavioral consequences of such deficits are unknown. Biological motion refers to the movements generated by living beings. The human visual system rapidly and effortlessly detects and extracts socially relevant information from biological motion. A deficit in biological motion perception may have significant consequences for detecting and interpreting social information. Schizophrenia patients and matched healthy controls were tested on two visual tasks: recognition of human activity portrayed in point-light animations (biological motion task) and a perceptual control task involving detection of a grouped figure against the background noise (global-form task). Both tasks required detection of a global form against background noise but only the biological motion task required the extraction of motion-related information. Schizophrenia patients performed as well as the controls in the global-form task, but were significantly impaired on the biological motion task. In addition, deficits in biological motion perception correlated with impaired social functioning as measured by the Zigler social competence scale [Zigler, E., Levine, J. (1981). Premorbid competence in schizophrenia: what is being measured? Journal of Consulting and Clinical Psychology, 49, 96-105.]. The deficit in biological motion processing, which may be related to the previously documented deficit in global motion processing, could contribute to abnormal social functioning in schizophrenia.

The effects of Global Fund financing on health governance in Brazil.

PubMed

Gómez, Eduardo J; Atun, Rifat

2012-07-16

The impact of donors, such as national government (bi-lateral), private sector, and individual financial (philanthropic) contributions, on domestic health policies of developing nations has been the subject of scholarly discourse. Little is known, however, about the impact of global financial initiatives, such as the Global Fund to Fight AIDS, Tuberculosis, and Malaria, on policies and health governance of countries receiving funding from such initiatives. This study employs a qualitative methodological design based on a single case study: Brazil. Analysis at national, inter-governmental and community levels is based on in-depth interviews with the Global Fund and the Brazilian Ministry of Health and civil societal activists. Primary research is complemented with information from printed media, reports, journal articles, and books, which were used to deepen our analysis while providing supporting evidence. Our analysis suggests that in Brazil, Global Fund financing has helped to positively transform health governance at three tiers of analysis: the national-level, inter-governmental-level, and community-level. At the national-level, Global Fund financing has helped to increased political attention and commitment to relatively neglected diseases, such as tuberculosis, while harmonizing intra-bureaucratic relationships; at the inter-governmental-level, Global Fund financing has motivated the National Tuberculosis Programme to strengthen its ties with state and municipal health departments, and non-governmental organisations (NGOs); while at the community-level, the Global Fund's financing of civil societal institutions has encouraged the emergence of new civic movements, participation, and the creation of new municipal participatory institutions designed to monitor the disbursement of funds for Global Fund grants. Global Fund financing can help deepen health governance at multiple levels. Future work will need to explore how the financing of civil society by the Global Fund and other donors influence policy agenda-setting and institutional innovations for increased civic participation in health governance and accountability to citizens.

The effects of Global Fund financing on health governance in Brazil

PubMed Central

2012-01-01

Objectives The impact of donors, such as national government (bi-lateral), private sector, and individual financial (philanthropic) contributions, on domestic health policies of developing nations has been the subject of scholarly discourse. Little is known, however, about the impact of global financial initiatives, such as the Global Fund to Fight AIDS, Tuberculosis, and Malaria, on policies and health governance of countries receiving funding from such initiatives. Methods This study employs a qualitative methodological design based on a single case study: Brazil. Analysis at national, inter-governmental and community levels is based on in-depth interviews with the Global Fund and the Brazilian Ministry of Health and civil societal activists. Primary research is complemented with information from printed media, reports, journal articles, and books, which were used to deepen our analysis while providing supporting evidence. Results Our analysis suggests that in Brazil, Global Fund financing has helped to positively transform health governance at three tiers of analysis: the national-level, inter-governmental-level, and community-level. At the national-level, Global Fund financing has helped to increased political attention and commitment to relatively neglected diseases, such as tuberculosis, while harmonizing intra-bureaucratic relationships; at the inter-governmental-level, Global Fund financing has motivated the National Tuberculosis Programme to strengthen its ties with state and municipal health departments, and non-governmental organisations (NGOs); while at the community-level, the Global Fund’s financing of civil societal institutions has encouraged the emergence of new civic movements, participation, and the creation of new municipal participatory institutions designed to monitor the disbursement of funds for Global Fund grants. Conclusions Global Fund financing can help deepen health governance at multiple levels. Future work will need to explore how the financing of civil society by the Global Fund and other donors influence policy agenda-setting and institutional innovations for increased civic participation in health governance and accountability to citizens. PMID:22799635

Seamline Determination Based on PKGC Segmentation for Remote Sensing Image Mosaicking

PubMed Central

Dong, Qiang; Liu, Jinghong

2017-01-01

This paper presents a novel method of seamline determination for remote sensing image mosaicking. A two-level optimization strategy is applied to determine the seamline. Object-level optimization is executed firstly. Background regions (BRs) and obvious regions (ORs) are extracted based on the results of parametric kernel graph cuts (PKGC) segmentation. The global cost map which consists of color difference, a multi-scale morphological gradient (MSMG) constraint, and texture difference is weighted by BRs. Finally, the seamline is determined in the weighted cost from the start point to the end point. Dijkstra’s shortest path algorithm is adopted for pixel-level optimization to determine the positions of seamline. Meanwhile, a new seamline optimization strategy is proposed for image mosaicking with multi-image overlapping regions. The experimental results show the better performance than the conventional method based on mean-shift segmentation. Seamlines based on the proposed method bypass the obvious objects and take less time in execution. This new method is efficient and superior for seamline determination in remote sensing image mosaicking. PMID:28749446

Identification of sources of environmental lead in South Africa from surface soil geochemical maps.

PubMed

de Villiers, Stephanie; Thiart, Christien; Basson, Nicholas C

2010-10-01

The bioavailability of lead in soil is of considerable importance to human and animal health. Although selective extraction has been explored as a more appropriate technique than total heavy metal analysis in environmental pollution assessments, such studies remain scarce globally and are almost non-existent in developing countries. Results for a large-scale study of extractable lead levels in undisturbed soil samples in South Africa identify several geographic areas of concern. Lead levels are considerably elevated relative to background levels in the Johannesburg urban and industrial area. Areas of active lead mining also exhibit higher surface soil values. Interestingly, areas of active and intensive coal mining activity display relatively low soil Pb values, possibly attributable to the relatively low heavy metal content of South African coal. In all instances, distribution of cadmium, a carcinogenic element, correlates with that of lead. The results demonstrate the usefulness of the quick and easy Mehlich-3 single extractant technique, an established technique in micronutrient studies, to simultaneously provide valuable environmental data for toxic metals such as Pb and Cd.

Detection of (133)Xe from the Fukushima nuclear power plant in the upper troposphere above Germany.

PubMed

Simgen, Hardy; Arnold, Frank; Aufmhoff, Heinfried; Baumann, Robert; Kaether, Florian; Lindemann, Sebastian; Rauch, Ludwig; Schlager, Hans; Schlosser, Clemens; Schumann, Ulrich

2014-06-01

After the accident in the Japanese Fukushima Dai-ichi nuclear power plant in March 2011 large amounts of radioactivity were released and distributed in the atmosphere. Among them were also radioactive noble gas isotopes which can be used as tracers to test global atmospheric circulation models. This work presents unique measurements of the radionuclide (133)Xe from Fukushima in the upper troposphere above Germany. The measurements involve air sampling in a research jet aircraft followed by chromatographic xenon extraction and ultra-low background gas counting with miniaturized proportional counters. With this technique a detection limit of the order of 100 (133)Xe atoms in liter-scale air samples (corresponding to about 100 mBq/m(3)) is achievable. Our results provide proof that the (133)Xe-rich ground level air layer from Fukushima was lifted up to the tropopause and distributed hemispherically. Moreover, comparisons with ground level air measurements indicate that the arrival of the radioactive plume at high altitude over Germany occurred several days before the ground level plume. Copyright © 2014 Elsevier Ltd. All rights reserved.

Relationship Between Speech Intelligibility and Speech Comprehension in Babble Noise.

PubMed

Fontan, Lionel; Tardieu, Julien; Gaillard, Pascal; Woisard, Virginie; Ruiz, Robert

2015-06-01

The authors investigated the relationship between the intelligibility and comprehension of speech presented in babble noise. Forty participants listened to French imperative sentences (commands for moving objects) in a multitalker babble background for which intensity was experimentally controlled. Participants were instructed to transcribe what they heard and obey the commands in an interactive environment set up for this purpose. The former test provided intelligibility scores and the latter provided comprehension scores. Collected data revealed a globally weak correlation between intelligibility and comprehension scores (r = .35, p < .001). The discrepancy tended to grow as noise level increased. An analysis of standard deviations showed that variability in comprehension scores increased linearly with noise level, whereas higher variability in intelligibility scores was found for moderate noise level conditions. These results support the hypothesis that intelligibility scores are poor predictors of listeners' comprehension in real communication situations. Intelligibility and comprehension scores appear to provide different insights, the first measure being centered on speech signal transfer and the second on communicative performance. Both theoretical and practical implications for the use of speech intelligibility tests as indicators of speakers' performances are discussed.

The relationship between social support and self-reported health status in immigrants: an adjusted analysis in the Madrid Cross Sectional Study

PubMed Central

2011-01-01

Background Social support is an important factor in the adaptation process of immigrants, helping for their integration in a new environment. The lack of social support may influence on well-being and health status. The aim of this study is to describe the social support of immigrant and native population and study the possible association between immigration and lack social support after adjusting for sociodemographic factors, income, stress and self-reported health status. Methods Cross-sectional population based study of immigrants and national patients without mental disorders of 15 urban primary health centers in the north-eastern area of Madrid. Participants provided information on social support, stress level, perceived health status and socio-economic characteristics. Descriptive and multiple logistic regression were conducted. Results The proportion of the global perception of social support among immigrants and natives was 79.2% and 94.2%, respectively. The lack of global social support adjusted prevalence ratio (PR) of immigrant was 2.72 (95% Confidence Interval = 1.81-4.09), showing a significant association with being male (PR = 2.26), having monthly income below 500 euros (PR = 3.81) and suffering stress (PR = 1.94). For the dimensions of lack of social support the higher association was being an immigrant and suffering stress. Conclusions We conclude that with regardless of the level of monthly income, stress level, self-reported health status, and gender, immigrant status is directly associated with lack social support. The variable most strongly associated with lack social support has been monthly income below 500 euros. PMID:21651759

Cumulative exposure to lead and cognition in persons with Parkinson’s disease

PubMed Central

Weuve, Jennifer; Press, Daniel Z.; Grodstein, Francine; Wright, Robert O.; Hu, Howard; Weisskopf, Marc G.

2012-01-01

Background Dementia is an important consequence of Parkinson’s disease (PD), with few known modifiable risk factors. Cumulative exposure to lead, at levels experienced in the community, may exacerbate PD-related neural dysfunction, resulting in impaired cognition. Methods Among 101 persons with PD (“cases”) and, separately, 50 persons without PD (“controls”), we evaluated cumulative lead exposure, gauged via tibia and patella bone lead concentrations, in relation to cognitive function, assessed using a telephone battery developed and validated in a separate sample of PD patients. We also assessed the interaction between lead and case-control status. Results After multivariable adjustment, higher tibia bone lead concentration among PD cases was associated with worse performance on all of the individual telephone tests. In particular, tibia lead levels corresponded to significantly worse performance on a telephone analogue of the Mini-Mental State Examination and tests of working memory and attention. Moreover, higher tibia bone lead concentration was associated with significantly worse global composite score encompassing all the cognitive tests (P=0.04). The magnitude of association per standard deviation increment in tibia bone lead level was equivalent to the difference in global scores among controls in our study who were about seven years apart in age. The tibia lead-cognition association was notably stronger within cases than within controls (Pdifference=0.06). Patella bone lead concentration was not consistently associated with performance on the tests. Conclusions These data provide evidence suggesting that cumulative exposure to lead may result in worsened cognition among persons with PD. PMID:23143985

SDTCP: Towards Datacenter TCP Congestion Control with SDN for IoT Applications.

PubMed

Lu, Yifei; Ling, Zhen; Zhu, Shuhong; Tang, Ling

2017-01-08

The Internet of Things (IoT) has gained popularity in recent years. Today's IoT applications are now increasingly deployed in cloud platforms to perform Big Data analytics. In cloud data center networks (DCN), TCP incast usually happens when multiple senders simultaneously communicate with a single receiver. However, when TCP incast happens, DCN may suffer from both throughput collapse for TCP burst flows and temporary starvation for TCP background flows. In this paper, we propose a software defined network (SDN)-based TCP congestion control mechanism, referred to as SDTCP, to leverage the features, e.g., centralized control methods and the global view of the network, in order to solve the TCP incast problems. When we detect network congestion on an OpenFlow switch, our controller can select the background flows and reduce their bandwidth by adjusting the advertised window of TCP ACK packets of the corresponding background flows so as to reserve more bandwidth for burst flows. SDTCP is transparent to the end systems and can accurately decelerate the rate of background flows by leveraging the global view of the network gained via SDN. The experiments demonstrate that our SDTCP can provide high tolerance for burst flows and achieve better flow completion time for short flows. Therefore, SDTCP is an effective and scalable solution for the TCP incast problem.

Migration background is associated with caries in Viennese school children, even if parents have received a higher education

PubMed Central

2014-01-01

Background A low level of education and the migration background of parents are associated with the development of caries in children. The aim of this study was to evaluate whether a higher educational level of parents can overcome risks for the development of caries in immigrants in Vienna, Austria. Methods The educational level of the parents, the school type, and the caries status of 736 randomly selected twelve-year-old children with and without migration background was determined in this cross sectional study. In children attending school in Vienna the decayed, missing, and filled teeth (DMFT) index was determined. For statistical analysis, a mixed negative-binomial-model was used. Results The caries status of the children with migration background was significantly worse compared to that of the native Viennese population. A significant interaction was found between migration background and the educational level of the parents (p = 0.045). No interaction was found between the school type and either the migration background (p = 0.220) or the education level of the parents (p = 0.08). In parents with a higher scholarly education level, migration background (p < 0.01) and school type (p = 0.018) showed an association with DMFT values. In parents with a low education level, however, migration background and school type had no significant association with DMFT values. Conclusion These data indicate that children with a migration background are at higher risk to acquire caries than other Viennese children, even when the parents have received a higher education. PMID:24886105

(Biased) Grading of Students' Performance: Students' Names, Performance Level, and Implicit Attitudes.

PubMed

Bonefeld, Meike; Dickhäuser, Oliver

2018-01-01

Biases in pre-service teachers' evaluations of students' performance may arise due to stereotypes (e.g., the assumption that students with a migrant background have lower potential). This study examines the effects of a migrant background, performance level, and implicit attitudes toward individuals with a migrant background on performance assessment (assigned grades and number of errors counted in a dictation). Pre-service teachers ( N = 203) graded the performance of a student who appeared to have a migrant background statistically significantly worse than that of a student without a migrant background. The differences were more pronounced when the performance level was low and when the pre-service teachers held relatively positive implicit attitudes toward individuals with a migrant background. Interestingly, only performance level had an effect on the number of counted errors. Our results support the assumption that pre-service teachers exhibit bias when grading students with a migrant background in a third-grade level dictation assignment.

(Biased) Grading of Students’ Performance: Students’ Names, Performance Level, and Implicit Attitudes

PubMed Central

Bonefeld, Meike; Dickhäuser, Oliver

2018-01-01

Biases in pre-service teachers’ evaluations of students’ performance may arise due to stereotypes (e.g., the assumption that students with a migrant background have lower potential). This study examines the effects of a migrant background, performance level, and implicit attitudes toward individuals with a migrant background on performance assessment (assigned grades and number of errors counted in a dictation). Pre-service teachers (N = 203) graded the performance of a student who appeared to have a migrant background statistically significantly worse than that of a student without a migrant background. The differences were more pronounced when the performance level was low and when the pre-service teachers held relatively positive implicit attitudes toward individuals with a migrant background. Interestingly, only performance level had an effect on the number of counted errors. Our results support the assumption that pre-service teachers exhibit bias when grading students with a migrant background in a third-grade level dictation assignment. PMID:29867618

Evaluation of simulated corn yields and associated uncertainty in different climate zones of China using Daycent Model

NASA Astrophysics Data System (ADS)

Fu, A.; Xue, Y.

2017-12-01

Corn is one of most important agricultural production in China. Research on the simulation of corn yields and the impacts of climate change and agricultural management practices on corn yields is important in maintaining the stable corn production. After climatic data including daily temperature, precipitation, solar radiation, relative humidity, and wind speed from 1948 to 2010, soil properties, observed corn yields, and farmland management information were collected, corn yields grown in humidity and hot environment (Sichuang province) and cold and dry environment (Hebei province) in China in the past 63 years were simulated by Daycent, and the results was evaluated based on published yield record. The relationship between regional climate change, global warming and corn yield were analyzed, the uncertainties of simulation derived from agricultural management practices by changing fertilization levels, land fertilizer maintenance and tillage methods were reported. The results showed that: (1) Daycent model is capable to simulate corn yields under the different climatic background in China. (2) When studying the relationship between regional climate change and corn yields, it has been found that observed and simulated corn yields increased along with total regional climate change. (3) When studying the relationship between the global warming and corn yields, It was discovered that newly-simulated corn yields after removing the global warming trend of original temperature data were lower than before.

Globalization and human cooperation

PubMed Central

Buchan, Nancy R.; Grimalda, Gianluca; Wilson, Rick; Brewer, Marilynn; Fatas, Enrique; Foddy, Margaret

2009-01-01

Globalization magnifies the problems that affect all people and that require large-scale human cooperation, for example, the overharvesting of natural resources and human-induced global warming. However, what does globalization imply for the cooperation needed to address such global social dilemmas? Two competing hypotheses are offered. One hypothesis is that globalization prompts reactionary movements that reinforce parochial distinctions among people. Large-scale cooperation then focuses on favoring one's own ethnic, racial, or language group. The alternative hypothesis suggests that globalization strengthens cosmopolitan attitudes by weakening the relevance of ethnicity, locality, or nationhood as sources of identification. In essence, globalization, the increasing interconnectedness of people worldwide, broadens the group boundaries within which individuals perceive they belong. We test these hypotheses by measuring globalization at both the country and individual levels and analyzing the relationship between globalization and individual cooperation with distal others in multilevel sequential cooperation experiments in which players can contribute to individual, local, and/or global accounts. Our samples were drawn from the general populations of the United States, Italy, Russia, Argentina, South Africa, and Iran. We find that as country and individual levels of globalization increase, so too does individual cooperation at the global level vis-à-vis the local level. In essence, “globalized” individuals draw broader group boundaries than others, eschewing parochial motivations in favor of cosmopolitan ones. Globalization may thus be fundamental in shaping contemporary large-scale cooperation and may be a positive force toward the provision of global public goods. PMID:19255433

The Imperative of Public Health Education: A Global Perspective

PubMed Central

White, Franklin

2013-01-01

This review positions public health as an endeavour that requires a high order of professionalism in addressing the health of populations; this requires investment in an educational capacity that is designed to meet this need. In the global context, the field has evolved enormously over the past half century, supported by institutions such as the World Bank, the World Health Organization and the Institute of Medicine. Operational structures are formulated by strategic principles, with educational and career pathways guided by competency frameworks, all requiring modulation according to local, national and global realities. Talented and well-motivated individuals are attracted by its multidisciplinary and transdisciplinary environment, and the opportunity to achieve interventions that make real differences to people's lives. The field is globally competitive and open to many professional backgrounds based on merit. Its competencies correspond with assessments of population needs, and the ways in which strategies and services are formulated. Thus, its educational planning is needs-based and evidence-driven. This review explores four public health education levels: graduate, undergraduate, continuing professional education and promotion of health literacy for general populations. The emergence of accreditation schemes is examined, focusing on their relative merits and legitimate international variations. The role of relevant research policies is recognized, along with the need to foster professional and institutional networks in all regions of the world. It is critically important for the health of populations that nations assess their public health human resource needs and develop their ability to deliver this capacity, and not depend on other countries to supply it. PMID:23969636

The 3,000 rice genomes project

PubMed Central

2014-01-01

Background Rice, Oryza sativa L., is the staple food for half the world’s population. By 2030, the production of rice must increase by at least 25% in order to keep up with global population growth and demand. Accelerated genetic gains in rice improvement are needed to mitigate the effects of climate change and loss of arable land, as well as to ensure a stable global food supply. Findings We resequenced a core collection of 3,000 rice accessions from 89 countries. All 3,000 genomes had an average sequencing depth of 14×, with average genome coverages and mapping rates of 94.0% and 92.5%, respectively. From our sequencing efforts, approximately 18.9 million single nucleotide polymorphisms (SNPs) in rice were discovered when aligned to the reference genome of the temperate japonica variety, Nipponbare. Phylogenetic analyses based on SNP data confirmed differentiation of the O. sativa gene pool into 5 varietal groups – indica, aus/boro, basmati/sadri, tropical japonica and temperate japonica. Conclusions Here, we report an international resequencing effort of 3,000 rice genomes. This data serves as a foundation for large-scale discovery of novel alleles for important rice phenotypes using various bioinformatics and/or genetic approaches. It also serves to understand the genomic diversity within O. sativa at a higher level of detail. With the release of the sequencing data, the project calls for the global rice community to take advantage of this data as a foundation for establishing a global, public rice genetic/genomic database and information platform for advancing rice breeding technology for future rice improvement. PMID:24872877

The Imperative of Public Health Education: A Global Perspective.

PubMed

White, Franklin

2013-01-01

This review positions public health as an endeavour that requires a high order of professionalism in addressing the health of populations; this requires investment in an educational capacity that is designed to meet this need. In the global context, the field has evolved enormously over the past half century, supported by institutions such as the World Bank, the World Health Organization and the Institute of Medicine. Operational structures are formulated by strategic principles, with educational and career pathways guided by competency frameworks, all requiring modulation according to local, national and global realities. Talented and well-motivated individuals are attracted by its multidisciplinary and transdisciplinary environment, and the opportunity to achieve interventions that make real differences to people's lives. The field is globally competitive and open to many professional backgrounds based on merit. Its competencies correspond with assessments of population needs, and the ways in which strategies and services are formulated. Thus, its educational planning is needs-based and evidence-driven. This review explores four public health education levels: graduate, undergraduate, continuing professional education and promotion of health literacy for general populations. The emergence of accreditation schemes is examined, focusing on their relative merits and legitimate international variations. The role of relevant research policies is recognized, along with the need to foster professional and institutional networks in all regions of the world. It is critically important for the health of populations that nations assess their public health human resource needs and develop their ability to deliver this capacity, and not depend on other countries to supply it. © 2013 S. Karger AG, Basel.

Conceptual Research of Lunar-based Earth Observation for Polar Glacier Motion

NASA Astrophysics Data System (ADS)

Ruan, Zhixing; Liu, Guang; Ding, Yixing

2016-07-01

The ice flow velocity of glaciers is important for estimating the polar ice sheet mass balance, and it is of great significance for studies into rising sea level under the background of global warming. However so far the long-term and global measurements of these macro-scale motion processes of the polar glaciers have hardly been achieved by Earth Observation (EO) technique from the ground, aircraft or satellites in space. This paper, facing the demand for space technology for large-scale global environmental change observation,especially the changes of polar glaciers, and proposes a new concept involving setting up sensors on the lunar surface and using the Moon as a platform for Earth observation, transmitting the data back to Earth. Lunar-based Earth observation, which enables the Earth's large-scale, continuous, long-term dynamic motions to be measured, is expected to provide a new solution to the problems mentioned above. According to the pattern and characteristics of polar glaciers motion, we will propose a comprehensive investigation of Lunar-based Earth observation with synthetic aperture radar (SAR). Via theoretical modeling and experimental simulation inversion, intensive studies of Lunar-based Earth observation for the glacier motions in the polar regions will be implemented, including the InSAR basics theory, observation modes of InSAR and optimization methods of their key parameters. It will be of a great help to creatively expand the EO technique system from space. In addition, they will contribute to establishing the theoretical foundation for the realization of the global, long-term and continuous observation for the glacier motion phenomena in the Antarctic and the Arctic.

Assessing the global reach and value of a provider-facing healthcare app using large-scale analytics

PubMed Central

Easton, George; Gillespie, Scott

2017-01-01

Background The rapid global adoption of mobile health (mHealth) smartphone apps by healthcare providers presents challenges and opportunities in medicine. Challenges include ensuring the delivery of high-quality, up-to-date and optimised information. Opportunities include the ability to study global practice patterns, access to medical and surgical care and continuing medical education needs. Methods We studied users of a free anaesthesia calculator app used worldwide. We combined traditional app analytics with in-app surveys to collect user demographics and feedback. Results 31 173 subjects participated. Users were from 206 countries and represented a spectrum of healthcare provider roles. Low-income country users had greater rates of app use (p<0.001) and ascribed greater importance of the app to their practice (p<0.001). Physicians from low-income countries were more likely to adopt the app (p<0.001). The app was used primarily for paediatric patients. The app was used around the clock, peaking during times typical for first start cases. Conclusions This mHealth app is a valuable decision support tool for global healthcare providers, particularly those in more resource-limited settings and with less training. App adoption and use may provide a mechanism for measuring longitudinal changes in access to surgical care and engaging providers in resource-limited settings. In-app surveys and app analytics provide a window into healthcare provider behaviour at a breadth and level of detail previously impossible to achieve. Given the potentially immense value of crowdsourced information, healthcare providers should be encouraged to participate in these types of studies. PMID:29082007

The global burden of neonatal hypothermia: systematic review of a major challenge for newborn survival

PubMed Central

2013-01-01

Background To provide evidence on the global epidemiological situation of neonatal hypothermia and to provide recommendations for future policy and research directions. Methods Using PubMed as our principal electronic reference library, we searched studies for prevalence and risk factor data on neonatal hypothermia in resource-limited environments globally. Studies specifying study location, setting (hospital or community based), sample size, case definition of body temperature for hypothermia, temperature measurement method, and point estimates for hypothermia prevalence were eligible for inclusion. Results Hypothermia is common in infants born at hospitals (prevalence range, 32% to 85%) and homes (prevalence range, 11% to 92%), even in tropical environments. The lack of thermal protection is still an underappreciated major challenge for newborn survival in developing countries. Although hypothermia is rarely a direct cause of death, it contributes to a substantial proportion of neonatal mortality globally, mostly as a comorbidity of severe neonatal infections, preterm birth, and asphyxia. Thresholds for the definition of hypothermia vary, and data on its prevalence in neonates is scarce, particularly on a community level in Africa. Conclusions A standardized approach to the collection and analysis of hypothermia data in existing newborn programs and studies is needed to inform policy and program planners on optimal thermal protection interventions. Thermoprotective behavior changes such as skin-to-skin care or the use of appropriate devices have not yet been scaled up globally. The introduction of simple hypothermia prevention messages and interventions into evidence-based, cost-effective packages for maternal and newborn care has promising potential to decrease the heavy global burden of newborn deaths attributable to severe infections, prematurity, and asphyxia. Because preventing and treating newborn hypothermia in health institutions and communities is relatively easy, addressing this widespread challenge might play a substantial role in reaching Millennium Development Goal 4, a reduction of child mortality. PMID:23369256

Exploring late Miocene climate stability: constraining background variability using high-resolution benthic δ18O and δ13C records from Site U1338

NASA Astrophysics Data System (ADS)

Drury, A.; John, C. M.; Lee, G.; Shevenell, A.

2012-12-01

The late Miocene (11.61 - 5.33 Ma) was one of the more stable climatic periods of the Cenozoic. Superimposed on this stable background climate, a number of threshold events occurred, including the late Miocene Carbon Isotope Shift (CIS, 7.6-6.6 Ma) and the Messinian Salinity Crisis (MSC, 5.96-5.33 Ma). The goal of our study is to constrain the background climate cyclicity during the late Miocene. A better knowledge of the background cyclicity in the Earth's climate system is required to advance understanding of, and to successfully model, climate variability. Improving understanding of how changes in background climate variability affect important parameters and fluxes, such as ice volume and the carbon pump, is crucial for explaining the occurrence of threshold events such as the CIS and MSC during an otherwise climatically stable period. The study site is located in the Eastern Equatorial Pacific (IODP Site U1338, Expedition 321). U1338 was chosen, as the equatorial Pacific is an important component of the global climate system, representing half of the total tropical ocean and a quarter of the global ocean. We present δ18O and δ13C records from 3.5 to 8.5 Ma using the benthic foraminiferal species Cibicidoides mundulus, with a resolution of 3-4 kyr, which resolves all Milankovitch scale cycles. We present a revised shipboard age model, generated from new biostratigraphic age constraints based on planktic foraminiferal datums. Benthic δ18O records at IODP Site U1338 reflect the stable nature of the late Miocene climate accurately, with long-term trends showing low-amplitude (0.2‰) variations. Superimposed on this are higher-amplitude short-term fluctuations (0.3-0.4‰). Deep-sea benthic foraminferal δ18O records both temperature and the δ18O composition of global deep seawater (δ18Odsw). δ18Odsw largely reflects glacio-eustatic change. Our benthic δ18O implies that long-term trends in ice volume were minimal during the late Miocene. However, the short-term variations imply that some significant sea level fluctuations occurred. The benthic δ13C long-term trend varies by ~0.75‰. The late Miocene CIS is visible as a ~1.25‰ excursion. Short-term fluctuations in δ13C record are slightly lower amplitude (~0.50‰). Preliminary spectral analysis highlights the strength of the eccentricity forcing (400 and 100-kyr cycles) in both the δ18O and δ13C records. The 41-kyr obliquity cycles are also visible in the δ18O records. The benthic δ13C records are combined with preliminary low-resolution δ13C records measured on the planktic foraminiferal species Globigerinoides sacculifer from the same samples. Co-varying benthic-planktic δ13C is driven by changes in the ocean reservoir δ13C, whereas con/diverging benthic-planktic δ13C is related to changes in surface productivity. This initial comparison may shed some light on the forcing of the CIS, and the implications for late Miocene climate. Future work will combine benthic δ18O with independent temperature proxies, such as Mg/Ca and clumped isotopes, to isolate the δ18Odsw signal and make more robust inferences about the background cryosphere dynamics during this time. We will also increase the resolution of the planktic foraminiferal records to enable comparison of the dominant forcing in the benthic and planktic records.

Enrolled nurse to registered nurse: is there a link between initial educational preparation and course completion?

PubMed

Rapley, Pat; Davidson, Laura; Nathan, Pauline; Dhaliwal, Satvinder S

2008-01-01

There is a shortage of registered nurses (RN) globally and equally in rural areas of Australia. The sparsely populated areas of rural Australia prompted the development of an external-mode EN-to-RN pathway course for enrolled nurses (EN) who want to complete a nursing degree. However, the awarding of advanced standing for EN clinical experience, regardless of educational background, is a new initiative that needs to be evaluated. Hence, this paper reports on the link between initial EN educational preparation and its impact on course completion. This exploratory correlation study used existing course data from four cohorts between 2000 and 2003. The comparisons included educational background, years of experience, and location of the EN-to-RN students. Significant differences were not found between rural and metropolitan students who completed or who withdrew from the course. Logistic regression analysis indicated that ENs in this sample with a hospital-based certificate rather than a technical college qualification were more likely to complete the course: Location and years of experience as an EN did not contribute significantly to course completion. The findings provide support for the same recognition of prior learning, regardless of educational background, for ENs entering a bachelor level nursing degree. The findings have relevance for Australia and other countries with similar challenges for ENs who want to become RNs without relocating to a city.

The Global Environment

NASA Astrophysics Data System (ADS)

Moore, John W.

2003-10-01

What can we teachers do? For students we can provide a strong background in the process of science and in scientific ethics. We can encourage students to apply such knowledge wisely throughout their lives. For the public at large, we can speak out in favor of real science at every opportunity. It is possible that the current scientific consensus on global warming is based on incomplete evidence, but global warming ought not be dismissed as unscientific or a hoax, and scientists ought not allow that to happen. As we celebrate National Chemistry Week, we should resolve to support chemistry and science as strongly as we can.

Global and regional trends in particulate air pollution and attributable health burden over the past 50 years

NASA Astrophysics Data System (ADS)

Butt, E. W.; Turnock, S. T.; Rigby, R.; Reddington, C. L.; Yoshioka, M.; Johnson, J. S.; Regayre, L. A.; Pringle, K. J.; Mann, G. W.; Spracklen, D. V.

2017-10-01

Long-term exposure to ambient particulate matter (PM2.5, mass of particles with an aerodynamic dry diameter of < 2.5 μm) is a major risk factor to the global burden of disease. Previous studies have focussed on present day or future health burdens attributed to ambient PM2.5. Few studies have estimated changes in PM2.5 and attributable health burdens over the last few decades, a period where air quality has changed rapidly. Here we used the HadGEM3-UKCA coupled chemistry-climate model, integrated exposure-response relationships, demographic and background disease data to provide the first estimate of the changes in global and regional ambient PM2.5 concentrations and attributable health burdens over the period 1960 to 2009. Over this period, global mean population-weighted PM2.5 concentrations increased by 38%, dominated by increases in China and India. Global attributable deaths increased by 89% to 124% over the period 1960 to 2009, dominated by large increases in China and India. Population growth and ageing contributed mostly to the increases in attributable deaths in China and India, highlighting the importance of demographic trends. In contrast, decreasing PM2.5 concentrations and background disease dominated the reduction in attributable health burden in Europe and the United States. Our results shed light on how future projected trends in demographics and uncertainty in the exposure-response relationship may provide challenges for future air quality policy in Asia.

Collective stochastic coherence in recurrent neuronal networks

NASA Astrophysics Data System (ADS)

Sancristóbal, Belén; Rebollo, Beatriz; Boada, Pol; Sanchez-Vives, Maria V.; Garcia-Ojalvo, Jordi

2016-09-01

Recurrent networks of dynamic elements frequently exhibit emergent collective oscillations, which can show substantial regularity even when the individual elements are considerably noisy. How noise-induced dynamics at the local level coexists with regular oscillations at the global level is still unclear. Here we show that a combination of stochastic recurrence-based initiation with deterministic refractoriness in an excitable network can reconcile these two features, leading to maximum collective coherence for an intermediate noise level. We report this behaviour in the slow oscillation regime exhibited by a cerebral cortex network under dynamical conditions resembling slow-wave sleep and anaesthesia. Computational analysis of a biologically realistic network model reveals that an intermediate level of background noise leads to quasi-regular dynamics. We verify this prediction experimentally in cortical slices subject to varying amounts of extracellular potassium, which modulates neuronal excitability and thus synaptic noise. The model also predicts that this effectively regular state should exhibit noise-induced memory of the spatial propagation profile of the collective oscillations, which is also verified experimentally. Taken together, these results allow us to construe the high regularity observed experimentally in the brain as an instance of collective stochastic coherence.

An Effective Method for Modeling Two-dimensional Sky Background of LAMOST

NASA Astrophysics Data System (ADS)

Haerken, Hasitieer; Duan, Fuqing; Zhang, Jiannan; Guo, Ping

2017-06-01

Each CCD of LAMOST accommodates 250 spectra, while about 40 are used to observe sky background during real observations. How to estimate the unknown sky background information hidden in the observed 210 celestial spectra by using the known 40 sky spectra is the problem we solve. In order to model the sky background, usually a pre-observation is performed with all fibers observing sky background. We use the observed 250 skylight spectra as training data, where those observed by the 40 fibers are considered as a base vector set. The Locality-constrained Linear Coding (LLC) technique is utilized to represent the skylight spectra observed by the 210 fibers with the base vector set. We also segment each spectrum into small parts, and establish the local sky background model for each part. Experimental results validate the proposed method, and show the local model is better than the global model.

A simple modification to the luminometric methylation assay to control for the effects of DNA fragmentation.

PubMed

Duman, Elif Aysimi; Kriaucionis, Skirmantas; Dunn, John J; Hatchwell, Eli

2015-05-01

Variations in DNA methylation have been implicated in a number of disorders. Changes in global DNA methylation levels have long been associated with various types of cancer. One of the recently described methods for determining global DNA methylation levels is the LUminometric Methylation Assay (LUMA), which utilizes methylation sensitive and insensitive restriction endonucleases and pyrosequencing technology for quantification. Here we provide evidence suggesting that the global methylation level reported by LUMA is affected by the integrity of the DNA being analyzed. The less intact the DNA, the lower the global methylation levels reported by LUMA. In order to overcome this problem, we propose the use of undigested DNA alongside digested samples. Finally, we demonstrate that this results in a more accurate assessment of global DNA methylation levels.

Constraining coastal change: A morpho-sedimentological concept to infer sea-level oscillation

NASA Astrophysics Data System (ADS)

Mauz, Barbara; Shen, Zhixiong

2016-04-01

One of the responders to Milankovitch-scale climate changes is sea level which, in turn, is a driver of coastal change. In literature, the sedimentary sequences representing the coastal change are often linked to high sea-level stands, to intermediate sea-level positions or to regressive shorelines. We note apparent contradictions that indicate a lack of concept and inconsistent usage of sea level-related terms. To overcome this, we combine an integrated morpho-sedimentological concept for microtidal, mid-latitudinal coasts with chronologies based on Bayesian statistics. The concept regards the coastal sedimentary system as a depositional complex consisting of shallow-marine, aeolian and alluvial facies. These facies are in juxtaposition and respond simultaneously to external forcing. Bayesian statistics constrains the timing of the sequence based on optical or radiocarbon ages. Here, we present the site Hergla located on the North African coast of the central Mediterranean Sea as a case study to illustrate how the approach helps eliminating contradictions. The site has been cited frequently for confirming the hypothesis of a global two peak sea-level highstand during the last interglacial (MIS 5e). The ~2 km cliff exposure at Hergla was surveyed, mapped, logged and sampled for further describing the sediments and their depositional environment through thin section and Bayesian modelling of optical ages. Using our concept based on sequence stratigraphy tools, the section is interpreted as representing a coastal barrier with two bounding surfaces in the succession. Both surfaces mark the falling sea level of, first, MIS 5e and, second, MIS 5a and hence bound the falling stage system tract of a forced regression. Part of the deposits between the two surfaces are pulled up onto the shoulder of a small rising horst and the associated tectonic event coincided with the MIS 5a sea-level rise enhancing locally the accommodation space for a second foreshore environment. Our presentation will provide theoretical background of the concept and critically discuss the global dataset for last interglacial sea-level oscillations using both the stratigraphic record and age distributions.

GPS system simulation methodology

NASA Technical Reports Server (NTRS)

Ewing, Thomas F.

1993-01-01

The following topics are presented: background; Global Positioning System (GPS) methodology overview; the graphical user interface (GUI); current models; application to space nuclear power/propulsion; and interfacing requirements. The discussion is presented in vugraph form.

Identifying interprofessional global health competencies for 21st-century health professionals.

PubMed

Jogerst, Kristen; Callender, Brian; Adams, Virginia; Evert, Jessica; Fields, Elise; Hall, Thomas; Olsen, Jody; Rowthorn, Virginia; Rudy, Sharon; Shen, Jiabin; Simon, Lisa; Torres, Herica; Velji, Anvar; Wilson, Lynda L

2015-01-01

At the 2008 inaugural meeting of the Consortium of Universities for Global Health (CUGH), participants discussed the rapid expansion of global health programs and the lack of standardized competencies and curricula to guide these programs. In 2013, CUGH appointed a Global Health Competency Subcommittee and charged this subcommittee with identifying broad global health core competencies applicable across disciplines. The purpose of this paper is to describe the Subcommittee's work and proposed list of interprofessional global health competencies. After agreeing on a definition of global health to guide the Subcommittee's work, members conducted an extensive literature review to identify existing competencies in all fields relevant to global health. Subcommittee members initially identified 82 competencies in 12 separate domains, and proposed four different competency levels. The proposed competencies and domains were discussed during multiple conference calls, and subcommittee members voted to determine the final competencies to be included in two of the four proposed competency levels (global citizen and basic operational level - program oriented). The final proposed list included a total of 13 competencies across 8 domains for the Global Citizen Level and 39 competencies across 11 domains for the Basic Operational Program-Oriented Level. There is a need for continued debate and dialog to validate the proposed set of competencies, and a need for further research to identify best strategies for incorporating these competencies into global health educational programs. Future research should focus on implementation and evaluation of these competencies across a range of educational programs, and further delineating the competencies needed across all four proposed competency levels. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

CALIPSO Detection of an Asian Tropopause Aerosol Layer

NASA Technical Reports Server (NTRS)

Vemier, J.-P.; Thomason, L. W.; Kar, J.

2011-01-01

The first four years of the CALIPSO lidar measurements have revealed the existence of an aerosol layer at the tropopause level associated with the Asian monsoon season in June, July and August. This Asian Tropopause Aerosol Layer (ATAL) extends geographically from Eastern Mediterranean (down to North Africa) to Western China (down to Thailand), and vertically from 13 to 18 km. The Scattering Ratio inferred from CALIPSO shows values between 1.10. 1.15 on average with associated depolarization ratio of less than 5%. The Gaussian distribution of the points indicates that the mean value is statistically driven by an enhancement of the background aerosol level and not by episodic events such as a volcanic eruption or cloud contamination. Further satellite observations of aerosols and gases as well as field campaigns are urgently needed to characterize this layer, which is likely to be a significant source of non-volcanic aerosols for the global upper troposphere with a potential impact on its radiative and chemical balance

Body Esteem and Self–examination in British Men and Women

PubMed Central

Brewer, Gayle; Dewhurst, Anne M.

2013-01-01

Background: Breast and testicular cancers affect a substantial and increasing proportion of the global population. Self-examination encourages early detection and treatment of these cancers, which positively impacts on patient quality of life and survival. Methods: The present study investigated the role of body esteem in breast and testicular self-examination. Men (N = 60) and women (N = 90) recruited from a British University completed the body esteem scale and either the testicular self-examination or breast self-examination questionnaire. Results: Logistic regression models revealed that body esteem predicted women's intention to engage in breast self-examination. Women with higher levels of sexual attractiveness and those with lower levels of weight concern were more likely to report that they would regularly self-examine in the future. Body esteem did not however, distinguish between those women that did or did not currently self-examine or predict men's current or intended testicular self-examination. Conclusion: The findings have implications for the promotion of self-examination and highlight an emerging area of preventive health research. PMID:23930186

Representing and comparing protein structures as paths in three-dimensional space

PubMed Central

Zhi, Degui; Krishna, S Sri; Cao, Haibo; Pevzner, Pavel; Godzik, Adam

2006-01-01

Background Most existing formulations of protein structure comparison are based on detailed atomic level descriptions of protein structures and bypass potential insights that arise from a higher-level abstraction. Results We propose a structure comparison approach based on a simplified representation of proteins that describes its three-dimensional path by local curvature along the generalized backbone of the polypeptide. We have implemented a dynamic programming procedure that aligns curvatures of proteins by optimizing a defined sum turning angle deviation measure. Conclusion Although our procedure does not directly optimize global structural similarity as measured by RMSD, our benchmarking results indicate that it can surprisingly well recover the structural similarity defined by structure classification databases and traditional structure alignment programs. In addition, our program can recognize similarities between structures with extensive conformation changes that are beyond the ability of traditional structure alignment programs. We demonstrate the applications of procedure to several contexts of structure comparison. An implementation of our procedure, CURVE, is available as a public webserver. PMID:17052359

Investigations of the Climate System Response to Climate Engineering in a Hierarchy of Models

NASA Astrophysics Data System (ADS)

McCusker, Kelly E.

Global warming due to anthropogenic emissions of greenhouse gases is causing negative impacts on diverse ecological and human systems around the globe, and these impacts are projected to worsen as climate continues to warm. In the absence of meaningful greenhouse gas emissions reductions, new strategies have been proposed to engineer the climate, with the aim of preventing further warming and avoiding associated climate impacts. We investigate one such strategy here, falling under the umbrella of `solar radiation management', in which sulfate aerosols are injected into the stratosphere. We use a global climate model with a coupled mixed-layer depth ocean and with a fully-coupled ocean general circulation model to simulate the stabilization of climate by balancing increasing carbon dioxide with increasing stratospheric sulfate concentrations. We evaluate whether or not severe climate impacts, such as melting Arctic sea ice, tropical crop failure, or destabilization of the West Antarctic ice sheet, could be avoided. We find that while tropical climate emergencies might be avoided by use of stratospheric aerosol injections, avoiding polar emergencies cannot be guaranteed due to large residual climate changes in those regions, which are in part due to residual atmospheric circulation anomalies. We also find that the inclusion of a fully-coupled ocean is important for determining the regional climate response because of its dynamical feedbacks. The efficacy of stratospheric sulfate aerosol injections, and solar radiation management more generally, depends on its ability to be maintained indefinitely, without interruption from a variety of possible sources, such as technological failure, a breakdown in global cooperation, lack of funding, or negative unintended consequences. We next consider the scenario in which stratospheric sulfate injections are abruptly terminated after a multi- decadal period of implementation while greenhouse gas emissions have continued unabated. We show that upon cessation, an abrupt, spatially broad, and sustained warming over land occurs that is well outside the bounds of 20th century climate variability. We then use an upwelling-diffusion energy balance climate model to further show the sensitivity of these trends to background greenhouse gas emissions, termination year, and climate sensitivity. We find that the rate of warming from cessation of solar radiation management -- of critical importance for ecological and human systems -- is principally controlled by the background greenhouse gas concentrations. It follows that the only way to avoid the risk of an abrupt and dangerous warming that is inherent to the large-scale implementation of solar radiation management is to also strongly reduce greenhouse gas emissions. The climate system responds to radiative forcing on a diverse spectrum of timescales, which will affect what goals can be achieved for a given stratospheric aerosol implementation. We next investigate how different rates of stratospheric sulfate aerosol deployment affect what climate impacts can be avoided by simulating two rates of increasing stratospheric sulfate concentrations in a fully-coupled global climate model. We find that disparate goals are achieved for different rates of deployment; for a slow ramping of sulfate, land surface temperature trends remain small but sea levels continue to rise for decades, whereas a quick ramp-up of sulfate yields large land surface cooling trends and immediately reduces sea level. However, atmospheric circulation changes also act to create a large-scale subsurface ocean environment around Antarctica that is favorable for increased basal melting of ice sheet outlets, thereby leaving the potential open for increased sea level rise even in the absence of large atmospheric surface warming. We show that instead, when greenhouse gases are abruptly returned to preindustrial levels, circulation anomalies are reversed, and the subsurface ocean environment does not pose the same threat to Antarctic ice sheets. We conclude that again, reduction of greenhouse gases is the preferred strategy for avoiding climate impacts of global warming.

Changes in the Arctic: Background and Issues for Congress

DTIC Science & Technology

2012-02-27

that most of the global warming of the last three decades is very likely caused by human-related emissions of greenhouse gases (GHG, mostly carbon...such warming is projected by most models throughout the Arctic, some models project slight cooling localized in the North Atlantic Ocean just south of...found that period to be distinctly different from the recent multi-decadal warming , in part because the current warmth is global . Changes in the

8 CFR 235.12 - Global Entry program.

Code of Federal Regulations, 2013 CFR

2013-01-01

... from the applicant (e.g., a set of ten fingerprints and/or digital photograph) to conduct background... letter should address any facts or conduct listed in the notification from CBP as contributing to the...

8 CFR 235.12 - Global Entry program.

Code of Federal Regulations, 2014 CFR

2014-01-01

... from the applicant (e.g., a set of ten fingerprints and/or digital photograph) to conduct background... letter should address any facts or conduct listed in the notification from CBP as contributing to the...

Effects of interior aircraft noise on speech intelligibility and annoyance

NASA Technical Reports Server (NTRS)

Pearsons, K. S.; Bennett, R. L.

1977-01-01

Recordings of the aircraft ambiance from ten different types of aircraft were used in conjunction with four distinct speech interference tests as stimuli to determine the effects of interior aircraft background levels and speech intelligibility on perceived annoyance in 36 subjects. Both speech intelligibility and background level significantly affected judged annoyance. However, the interaction between the two variables showed that above an 85 db background level the speech intelligibility results had a minimal effect on annoyance ratings. Below this level, people rated the background as less annoying if there was adequate speech intelligibility.

Outdoor Air Pollution, Preterm Birth, and Low Birth Weight: Analysis of the World Health Organization Global Survey on Maternal and Perinatal Health

PubMed Central

Merialdi, Mario; van Donkelaar, Aaron; Vadillo-Ortega, Felipe; Martin, Randall V.; Betran, Ana Pilar; Souza, João Paulo

2014-01-01

Background: Inhaling fine particles (particulate matter with diameter ≤ 2.5 μm; PM2.5) can induce oxidative stress and inflammation, and may contribute to onset of preterm labor and other adverse perinatal outcomes. Objectives: We examined whether outdoor PM2.5 was associated with adverse birth outcomes among 22 countries in the World Health Organization Global Survey on Maternal and Perinatal Health from 2004 through 2008. Methods: Long-term average (2001–2006) estimates of outdoor PM2.5 were assigned to 50-km–radius circular buffers around each health clinic where births occurred. We used generalized estimating equations to determine associations between clinic-level PM2.5 levels and preterm birth and low birth weight at the individual level, adjusting for seasonality and potential confounders at individual, clinic, and country levels. Country-specific associations were also investigated. Results: Across all countries, adjusting for seasonality, PM2.5 was not associated with preterm birth, but was associated with low birth weight [odds ratio (OR) = 1.22; 95% CI: 1.07, 1.39 for fourth quartile of PM2.5 (> 20.2 μg/m3) compared with the first quartile (< 6.3 μg/m3)]. In China, the country with the largest PM2.5 range, preterm birth and low birth weight both were associated with the highest quartile of PM2.5 only, which suggests a possible threshold effect (OR = 2.54; CI: 1.42, 4.55 and OR = 1.99; CI: 1.06, 3.72 for preterm birth and low birth weight, respectively, for PM2.5 ≥ 36.5 μg/m3 compared with PM2.5 < 12.5 μg/m3). Conclusions: Outdoor PM2.5 concentrations were associated with low birth weight but not preterm birth. In rapidly developing countries, such as China, the highest levels of air pollution may be of concern for both outcomes. Citation: Fleischer NL, Merialdi M, van Donkelaar A, Vadillo-Ortega F, Martin RV, Betran AP, Souza JP, O´Neill MS. 2014. Outdoor air pollution, preterm birth, and low birth weight: analysis of the World Health Organization Global Survey on Maternal and Perinatal Health. Environ Health Perspect 122:425–430; http://dx.doi.org/10.1289/ehp.1306837 PMID:24508912

6d, Coulomb branch anomaly matching

NASA Astrophysics Data System (ADS)

Intriligator, Kenneth

2014-10-01

6d QFTs are constrained by the analog of 't Hooft anomaly matching: all anomalies for global symmetries and metric backgrounds are constants of RG flows, and for all vacua in moduli spaces. We discuss an anomaly matching mechanism for 6d theories on their Coulomb branch. It is a global symmetry analog of Green-Schwarz-West-Sagnotti anomaly cancellation, and requires the apparent anomaly mismatch to be a perfect square, . Then Δ I 8 is cancelled by making X 4 an electric/magnetic source for the tensor multiplet, so background gauge field instantons yield charged strings. This requires the coefficients in X 4 to be integrally quantized. We illustrate this for theories. We also consider the SCFTs from N small E8 instantons, verifying that the recent result for its anomaly polynomial fits with the anomaly matching mechanism.

Relative arrival-time upper-mantle tomography and the elusive background mean

NASA Astrophysics Data System (ADS)

Bastow, Ian D.

2012-08-01

The interpretation of seismic tomographic images of upper-mantle seismic wave speed structure is often a matter of considerable debate because the observations can usually be explained by a range of hypotheses, including variable temperature, composition, anisotropy, and the presence of partial melt. An additional problem, often overlooked in tomographic studies using relative as opposed to absolute arrival-times, is the issue of the resulting velocity model's zero mean. In shield areas, for example, relative arrival-time analysis strips off a background mean velocity structure that is markedly fast compared to the global average. Conversely, in active areas, the background mean is often markedly slow compared to the global average. Appreciation of this issue is vital when interpreting seismic tomographic images: 'high' and 'low' velocity anomalies should not necessarily be interpreted, respectively, as 'fast' and 'slow' compared to 'normal mantle'. This issue has been discussed in the seismological literature in detail over the years, yet subsequent tomography studies have still fallen into the trap of mis-interpreting their velocity models. I highlight here some recent examples of this and provide a simple strategy to address the problem using constraints from a recent global tomographic model, and insights from catalogues of absolute traveltime anomalies. Consultation of such absolute measures of seismic wave speed should be routine during regional tomographic studies, if only for the benefit of the broader Earth Science community, who readily follow the red = hot and slow, blue = cold and fast rule of thumb when interpreting the images for themselves.

Fast Scattering Code (FSC) User's Manual: Version 2

NASA Technical Reports Server (NTRS)

Tinetti, Ana F.; Dun, M. H.; Pope, D. Stuart

2006-01-01

The Fast Scattering Code (version 2.0) is a computer program for predicting the three-dimensional scattered acoustic field produced by the interaction of known, time-harmonic, incident sound with aerostructures in the presence of potential background flow. The FSC has been developed for use as an aeroacoustic analysis tool for assessing global effects on noise radiation and scattering caused by changes in configuration (geometry, component placement) and operating conditions (background flow, excitation frequency).

What are the implications of rapid global warming for landslide-triggered turbidity current activity?

NASA Astrophysics Data System (ADS)

Clare, Michael; Peter, Talling; James, Hunt

2014-05-01

A geologically short-lived (~170kyr) episode of global warming occurred at ~55Ma, termed the Initial Eocene Thermal Maximum (IETM). Global temperatures rose by up to 8oC over only ~10kyr and a massive perturbation of the global carbon cycle occurred; creating a negative carbon isotopic (~-4% δ13C) excursion in sedimentary records. This interval has relevance to study of future climate change and its influence on geohazards including submarine landslides and turbidity currents. We analyse the recurrence frequency of turbidity currents, potentially initiated from large-volume slope failures. The study focuses on two sedimentary intervals that straddle the IETM and we discuss implications for turbidity current triggering. We present the results of statistical analyses (regression, generalised linear model, and proportional hazards model) for extensive turbidite records from an outcrop at Zumaia in NE Spain (N=285; 54.0 to 56.5 Ma) and based on ODP site 1068 on the Iberian Margin (N=1571; 48.2 to 67.6 Ma). The sedimentary sequences provide clear differentiation between hemipelagic and turbiditic mud with only negligible evidence of erosion. We infer dates for turbidites by converting hemipelagic bed thicknesses to time using interval-averaged accumulation rates. Multi-proxy dating techniques provide good age constraint. The background trend for the Zumaia record shows a near-exponential distribution of turbidite recurrence intervals, while the Iberian Margin shows a log-normal response. This is interpreted to be related to regional time-independence (exponential) and the effects of additive processes (log-normal). We discuss how a log-normal response may actually be generated over geological timescales from multiple shorter periods of random turbidite recurrence. The IETM interval shows a dramatic departure from both these background trends, however. This is marked by prolonged hiatuses (0.1 and 0.6 Myr duration) in turbidity current activity in contrast to the arithmetic mean recurrence, λ, for the full records (λ=0.007 and 0.0125 Myr). This period of inactivity is coincident with a dramatic carbon isotopic excursion (i.e. warmest part of the IETM) and heavily skews statistical analyses for both records. Dramatic global warming appears to exert a strong control on inhibiting turbidity current activity; whereas the effects of sea level change are not shown to be statistically significant. Rapid global warming is often implicated as a potential landslide trigger, due to dissociation of gas hydrates in response to elevated ocean temperatures. Other studies have suggested that intense global warming may actually be attributed to the atmospheric release of gas hydrates following catastrophic failure of large parts of a continental slope. Either way, a greater intensity of landslide and resultant turbidity current activity would be expected during the IETM; however, our findings are to the contrary. We offer some explanations in relation to potential triggers. Our work suggests that previous rapid global warming at the IETM did not trigger more frequent turbidity currents. This has direct relevance to future assessments relating to landslide-triggered tsunami hazard, and breakage of subsea cables by turbidity currents.

KSC-06pd0211

NASA Image and Video Library

2006-02-07

KENNEDY SPACE CENTER, FLA. - During fueling of the Virgin Atlantic GlobalFlyer before dawn on NASA Kennedy Space Center’s Shuttle Landing Facility (SLF), Sir Richard Branson talks to the media. Branson is chairman and founder of Virgin Atlantic. The GlobalFlyer is in the background. Steve Fossett will pilot the GlobalFlyer on a record-breaking attempt by flying solo, non-stop without refueling, to surpass the current record for the longest flight of any aircraft. Fossett is expected to take off from the KSC SLF. Later, takeoff of the GlobalFlyer was postponed due to a fuel leak that appeared during the last moments of loading. The next planned takeoff attempt is 7 a.m. Feb. 8 from the SLF. Photo credit: NASA/Kim Shiflett

KSC-06pd0210

NASA Image and Video Library

2006-02-07

KENNEDY SPACE CENTER, FLA. - During fueling of the Virgin Atlantic GlobalFlyer before dawn on NASA Kennedy Space Center’s Shuttle Landing Facility (SLF), Sir Richard Branson talks to the media. Branson is chairman and founder of Virgin Atlantic. The GlobalFlyer is in the background. Steve Fossett will pilot the GlobalFlyer on a record-breaking attempt by flying solo, non-stop without refueling, to surpass the current record for the longest flight of any aircraft. Fossett is expected to take off from the KSC SLF. Later, takeoff of the GlobalFlyer was postponed due to a fuel leak that appeared during the last moments of loading. The next planned takeoff attempt is 7 a.m. Feb. 8 from the SLF. Photo credit: NASA/Kim Shiflett

Global Change Encyclopedia - A project for the international space year

NASA Technical Reports Server (NTRS)

Cihlar, J.; Simard, R.; Manore, M.; Baker, R.; Clark, D.; Kineman, J.; Allen, J.; Ruzek, M.

1991-01-01

'Global Change Encyclopedia' is a project for the International Space Year in 1992. The project will produce a comprehensive set of satellite and other global data with relevance to studies of global change and of the earth as a system. These data will be packaged on CD-ROMs, accompanied by appropriate software for access, display and manipulation. On behalf of the Canadian Space Agency, the project is being carried out by the Canada Centre for Remote Sensing, with the U.S. National Oceanic and Atmospheric Administration and the U.S. National Aeronautics and Space Administration as major contributors. This paper highlights the background leading to the project, the concept and principal characteristics of the Encyclopedia itself, and the current status and plans.

Migration background is associated with caries in Viennese school children, even if parents have received a higher education.

PubMed

Cvikl, Barbara; Haubenberger-Praml, Gertraud; Drabo, Petra; Hagmann, Michael; Gruber, Reinhard; Moritz, Andreas; Nell, Andrea

2014-05-09

A low level of education and the migration background of parents are associated with the development of caries in children. The aim of this study was to evaluate whether a higher educational level of parents can overcome risks for the development of caries in immigrants in Vienna, Austria. The educational level of the parents, the school type, and the caries status of 736 randomly selected twelve-year-old children with and without migration background was determined in this cross sectional study. In children attending school in Vienna the decayed, missing, and filled teeth (DMFT) index was determined. For statistical analysis, a mixed negative-binomial-model was used. The caries status of the children with migration background was significantly worse compared to that of the native Viennese population. A significant interaction was found between migration background and the educational level of the parents (p = 0.045). No interaction was found between the school type and either the migration background (p = 0.220) or the education level of the parents (p = 0.08). In parents with a higher scholarly education level, migration background (p < 0.01) and school type (p = 0.018) showed an association with DMFT values. In parents with a low education level, however, migration background and school type had no significant association with DMFT values. These data indicate that children with a migration background are at higher risk to acquire caries than other Viennese children, even when the parents have received a higher education.

Cross cultural differences in unconscious knowledge.

PubMed

Kiyokawa, Sachiko; Dienes, Zoltán; Tanaka, Daisuke; Yamada, Ayumi; Crowe, Louise

2012-07-01

Previous studies have indicated cross cultural differences in conscious processes, such that Asians have a global preference and Westerners a more analytical one. We investigated whether these biases also apply to unconscious knowledge. In Experiment 1, Japanese and UK participants memorized strings of large (global) letters made out of small (local) letters. The strings constituted one sequence of letters at a global level and a different sequence at a local level. Implicit learning occurred at the global and not the local level for the Japanese but equally at both levels for the English. In Experiment 2, the Japanese preference for global over local processing persisted even when structure existed only at the local but not global level. In Experiment 3, Japanese and UK participants were asked to attend to just one of the levels, global or local. Now the cultural groups performed similarly, indicating that the bias largely reflects preference rather than ability (although the data left room for residual ability differences). In Experiment 4, the greater global advantage of Japanese rather English was confirmed for strings made of Japanese kana rather than Roman letters. That is, the cultural difference is not due to familiarity of the sequence elements. In sum, we show for the first time that cultural biases strongly affect the type of unconscious knowledge people acquire. Copyright © 2012 Elsevier B.V. All rights reserved.

Regional Variation in the Prevalence of E. coli O157 in Cattle: A Meta-Analysis and Meta-Regression

PubMed Central

Islam, Md. Zohorul; Musekiwa, Alfred; Islam, Kamrul; Ahmed, Shahana; Chowdhury, Sharmin; Ahad, Abdul; Biswas, Paritosh Kumar

2014-01-01

Background Escherichia coli O157 (EcO157) infection has been recognized as an important global public health concern. But information on the prevalence of EcO157 in cattle at the global and at the wider geographical levels is limited, if not absent. This is the first meta-analysis to investigate the point prevalence of EcO157 in cattle at the global level and to explore the factors contributing to variation in prevalence estimates. Methods Seven electronic databases- CAB Abstracts, PubMed, Biosis Citation Index, Medline, Web of Knowledge, Scirus and Scopus were searched for relevant publications from 1980 to 2012. A random effect meta-analysis model was used to produce the pooled estimates. The potential sources of between study heterogeneity were identified using meta-regression. Principal findings A total of 140 studies consisting 220,427 cattle were included in the meta-analysis. The prevalence estimate of EcO157 in cattle at the global level was 5.68% (95% CI, 5.16–6.20). The random effects pooled prevalence estimates in Africa, Northern America, Oceania, Europe, Asia and Latin America-Caribbean were 31.20% (95% CI, 12.35–50.04), 7.35% (95% CI, 6.44–8.26), 6.85% (95% CI, 2.41–11.29), 5.15% (95% CI, 4.21–6.09), 4.69% (95% CI, 3.05–6.33) and 1.65% (95% CI, 0.77–2.53), respectively. Between studies heterogeneity was evidenced in most regions. World region (p<0.001), type of cattle (p<0.001) and to some extent, specimens (p = 0.074) as well as method of pre-enrichment (p = 0.110), were identified as factors for variation in the prevalence estimates of EcO157 in cattle. Conclusion The prevalence of the organism seems to be higher in the African and Northern American regions. The important factors that might have influence in the estimates of EcO157 are type of cattle and kind of screening specimen. Their roles need to be determined and they should be properly handled in any survey to estimate the true prevalence of EcO157. PMID:24691253

Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

PubMed Central

2012-01-01

Background Age-related macular degeneration (AMD) is a leading cause of blindness that affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural retina. Initially characterized by an accumulation of sub-RPE deposits, AMD leads to progressive retinal degeneration, and in advanced cases, irreversible vision loss. Although genetic analysis, animal models, and cell culture systems have yielded important insights into AMD, the molecular pathways underlying AMD's onset and progression remain poorly delineated. We sought to better understand the molecular underpinnings of this devastating disease by performing the first comparative transcriptome analysis of AMD and normal human donor eyes. Methods RPE-choroid and retina tissue samples were obtained from a common cohort of 31 normal, 26 AMD, and 11 potential pre-AMD human donor eyes. Transcriptome profiles were generated for macular and extramacular regions, and statistical and bioinformatic methods were employed to identify disease-associated gene signatures and functionally enriched protein association networks. Selected genes of high significance were validated using an independent donor cohort. Results We identified over 50 annotated genes enriched in cell-mediated immune responses that are globally over-expressed in RPE-choroid AMD phenotypes. Using a machine learning model and a second donor cohort, we show that the top 20 global genes are predictive of AMD clinical diagnosis. We also discovered functionally enriched gene sets in the RPE-choroid that delineate the advanced AMD phenotypes, neovascular AMD and geographic atrophy. Moreover, we identified a graded increase of transcript levels in the retina related to wound response, complement cascade, and neurogenesis that strongly correlates with decreased levels of phototransduction transcripts and increased AMD severity. Based on our findings, we assembled protein-protein interactomes that highlight functional networks likely to be involved in AMD pathogenesis. Conclusions We discovered new global biomarkers and gene expression signatures of AMD. These results are consistent with a model whereby cell-based inflammatory responses represent a central feature of AMD etiology, and depending on genetics, environment, or stochastic factors, may give rise to the advanced AMD phenotypes characterized by angiogenesis and/or cell death. Genes regulating these immunological activities, along with numerous other genes identified here, represent promising new targets for AMD-directed therapeutics and diagnostics. Please see related commentary: http://www.biomedcentral.com/1741-7015/10/21/abstract PMID:22364233

On the background independence of two-dimensional topological gravity

NASA Astrophysics Data System (ADS)

Imbimbo, Camillo

1995-04-01

We formulate two-dimensional topological gravity in a background covariant Lagrangian framework. We derive the Ward identities which characterize the dependence of physical correlators on the background world-sheet metric defining the gauge-slice. We point out the existence of an "anomaly" in Ward identitites involving correlators of observables with higher ghost number. This "anomaly" represents an obstruction for physical correlators to be globally defined forms on moduli space which could be integrated in a background independent way. Starting from the anomalous Ward identities, we derive "descent" equations whose solutions are cocycles of the Lie algebra of the diffeomorphism group with values in the space of local forms on the moduli space. We solve the descent equations and provide explicit formulas for the cocycles, which allow for the definition of background independent integrals of physical correlators on the moduli space.

Integration of Grid and Local Batch Resources at DESY

NASA Astrophysics Data System (ADS)

Beyer, Christoph; Finnern, Thomas; Gellrich, Andreas; Hartmann, Thomas; Kemp, Yves; Lewendel, Birgit

2017-10-01

As one of the largest resource centres DESY has to support differing work flows of users from various scientific backgrounds. Users can be for one HEP experiments in WLCG or Belle II as well as local HEP users but also physicists from other fields as photon science or accelerator development. By abandoning specific worker node setups in favour of generic flat nodes with middleware resources provided via CVMFS, we gain flexibility to subsume different use cases in a homogeneous environment. Grid jobs and the local batch system are managed in a HTCondor based setup, accepting pilot, user and containerized jobs. The unified setup allows dynamic re-assignment of resources between the different use cases. Monitoring is implemented on global batch system metrics as well as on a per job level utilizing corresponding cgroup information.

Guatemala’s Ministry of Health Rapid Response Team Manuals

PubMed Central

Hernandez, Luis; Hanson, Kimberly M.; Martel, Lise D.

2017-01-01

The function of public health rapid response teams (RRTs) is to quickly identify, investigate, and control an outbreak before it can spread. The Central America Regional Office in Guatemala provided assistance to the Guatemalan Ministry of Health and Social Assistance (MSPAS) to develop RRT manuals at the district and regional levels. The manuals are divided into 4 sections: background, activity lists, standard operating procedures, and annexes. The manuals outline Guatemala’s RRT members’ responsibilities and will be tested in the near future through tabletop exercises. The development of the manuals is a concrete and significant step toward the attainment of Guatemala’s IHR goals and should be integrated into a larger emergency management system to promote “a world safe and secure from global health threats posed by infectious diseases.” PMID:25254918

Holocene Faunal Trends in West Siberia and Their Causes

NASA Astrophysics Data System (ADS)

Gashev, S. N.; Aleshina, A. O.; Zuban, I. A.; Lupinos, M. Y.; Mardonova, L. B.; Mitropolskiy, M. G.; Selyukov, A. G.; Sorokina, N. V.; Stolbov, V. A.; Shapovalov, S. I.

2017-12-01

Based on an analysis of the transformation of vertebrate and invertebrate fauna of West Siberia in the Holocene, the classification and periodization of the main faunal trends are presented. Against the background of changing environmental conditions, the key regularities of the faunal dynamics, and the ways some species penetrate into the territory of the region and others disappear from the beginning of the Holocene to the present time have been indicated. Three global and four fluctuating trends are identified. The anthropogenic trend is ascertained separately. A conclusion is made about the prevailing causes of these changes, associated primarily with periodic climatic processes of different levels, determined by planetary geological and cosmic cycles. It is emphasized that, in the historical period, anthropogenic factors play a significant role in the regional faunal dynamics.

Effects of global and local contexts on chord processing: An ERP study.

PubMed

Zhang, Jingjing; Zhou, Xuefeng; Chang, Ruohan; Yang, Yufang

2018-01-31

In real life, the processing of an incoming event is continuously influenced by prior information at multiple timescales. The present study investigated how harmonic contexts at both local and global levels influence the processing of an incoming chord in an event-related potentials experiment. Chord sequences containing two phrases were presented to musically trained listeners, with the last critical chord either harmonically related or less related to its preceding context at local and/or global levels. ERPs data showed an ERAN-like effect for local context in early time window and a N5-like component for later interaction between the local context and global context. These results suggest that both the local and global contexts influence the processing of an incoming music event, and the local effect happens earlier than the global. Moreover, the interaction between the local context and global context in N5 may suggest that music syntactic integration at local level takes place prior to the integration at global level. Copyright © 2017 Elsevier Ltd. All rights reserved.

Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis.

PubMed

Woo, Hae Dong; Kim, Jeongseon

2012-01-01

Good biomarkers for early detection of cancer lead to better prognosis. However, harvesting tumor tissue is invasive and cannot be routinely performed. Global DNA methylation of peripheral blood leukocyte DNA was evaluated as a biomarker for cancer risk. We performed a meta-analysis to estimate overall cancer risk according to global DNA hypomethylation levels among studies with various cancer types and analytical methods used to measure DNA methylation. Studies were systemically searched via PubMed with no language limitation up to July 2011. Summary estimates were calculated using a fixed effects model. The subgroup analyses by experimental methods to determine DNA methylation level were performed due to heterogeneity within the selected studies (p<0.001, I(2): 80%). Heterogeneity was not found in the subgroup of %5-mC (p = 0.393, I(2): 0%) and LINE-1 used same target sequence (p = 0.097, I(2): 49%), whereas considerable variance remained in LINE-1 (p<0.001, I(2): 80%) and bladder cancer studies (p = 0.016, I(2): 76%). These results suggest that experimental methods used to quantify global DNA methylation levels are important factors in the association study between hypomethylation levels and cancer risk. Overall, cancer risks of the group with the lowest DNA methylation levels were significantly higher compared to the group with the highest methylation levels [OR (95% CI): 1.48 (1.28-1.70)]. Global DNA hypomethylation in peripheral blood leukocytes may be a suitable biomarker for cancer risk. However, the association between global DNA methylation and cancer risk may be different based on experimental methods, and region of DNA targeted for measuring global hypomethylation levels as well as the cancer type. Therefore, it is important to select a precise and accurate surrogate marker for global DNA methylation levels in the association studies between global DNA methylation levels in peripheral leukocyte and cancer risk.

Quasi two day wave-related variability in the background dynamics and composition of the mesosphere/thermosphere and the ionosphere

PubMed Central

Chang, Loren C; Yue, Jia; Wang, Wenbin; Wu, Qian; Meier, R R

2014-01-01

Dissipating planetary waves in the mesosphere/lower thermosphere (MLT) region may cause changes in the background dynamics of that region, subsequently driving variability throughout the broader thermosphere/ionosphere system via mixing due to the induced circulation changes. We report the results of case studies examining the possibility of such coupling during the northern winter in the context of the quasi two day wave (QTDW)—a planetary wave that recurrently grows to large amplitudes from the summer MLT during the postsolstice period. Six distinct QTDW events between 2003 and 2011 are identified in the MLT using Sounding of the Atmosphere using Broadband Emission Radiometry temperature observations. Concurrent changes to the background zonal winds, zonal mean column O/N2 density ratio, and ionospheric total electron content (TEC) are examined using data sets from Thermosphere Ionosphere Mesosphere Energetics and Dynamics Doppler Interferometer, Global Ultraviolet Imager, and Global Ionospheric Maps, respectively. We find that in the 5–10 days following a QTDW event, the background zonal winds in the MLT show patterns of eastward and westward anomalies in the low and middle latitudes consistent with past modeling studies on QTDW-induced mean wind forcing, both below and at turbopause altitudes. This is accompanied by potentially related decreases in zonal mean thermospheric column O/N2, as well as to low-latitude TECs. The recurrent nature of the above changes during the six QTDW events examined point to an avenue for vertical coupling via background dynamics and chemistry of the thermosphere/ionosphere not previously observed. Key Points Dissipating planetary waves (PWs) in the MLT can drive background wind changes Mixing from dissipating PWs drive thermosphere/ionosphere composition changes First observations of QTDW-driven variability from this mechanism PMID:26312201

Quasi two day wave-related variability in the background dynamics and composition of the mesosphere/thermosphere and the ionosphere.

PubMed

Chang, Loren C; Yue, Jia; Wang, Wenbin; Wu, Qian; Meier, R R

2014-06-01

Dissipating planetary waves in the mesosphere/lower thermosphere (MLT) region may cause changes in the background dynamics of that region, subsequently driving variability throughout the broader thermosphere/ionosphere system via mixing due to the induced circulation changes. We report the results of case studies examining the possibility of such coupling during the northern winter in the context of the quasi two day wave (QTDW)-a planetary wave that recurrently grows to large amplitudes from the summer MLT during the postsolstice period. Six distinct QTDW events between 2003 and 2011 are identified in the MLT using Sounding of the Atmosphere using Broadband Emission Radiometry temperature observations. Concurrent changes to the background zonal winds, zonal mean column O/N 2 density ratio, and ionospheric total electron content (TEC) are examined using data sets from Thermosphere Ionosphere Mesosphere Energetics and Dynamics Doppler Interferometer, Global Ultraviolet Imager, and Global Ionospheric Maps, respectively. We find that in the 5-10 days following a QTDW event, the background zonal winds in the MLT show patterns of eastward and westward anomalies in the low and middle latitudes consistent with past modeling studies on QTDW-induced mean wind forcing, both below and at turbopause altitudes. This is accompanied by potentially related decreases in zonal mean thermospheric column O/N 2 , as well as to low-latitude TECs. The recurrent nature of the above changes during the six QTDW events examined point to an avenue for vertical coupling via background dynamics and chemistry of the thermosphere/ionosphere not previously observed. Dissipating planetary waves (PWs) in the MLT can drive background wind changesMixing from dissipating PWs drive thermosphere/ionosphere composition changesFirst observations of QTDW-driven variability from this mechanism.

AO Distal Radius Fracture Classification: Global Perspective on Observer Agreement.

PubMed

Jayakumar, Prakash; Teunis, Teun; Giménez, Beatriz Bravo; Verstreken, Frederik; Di Mascio, Livio; Jupiter, Jesse B

2017-02-01

Background  The primary objective of this study was to test interobserver reliability when classifying fractures by consensus by AO types and groups among a large international group of surgeons. Secondarily, we assessed the difference in inter- and intraobserver agreement of the AO classification in relation to geographical location, level of training, and subspecialty. Methods  A randomized set of radiographic and computed tomographic images from a consecutive series of 96 distal radius fractures (DRFs), treated between October 2010 and April 2013, was classified using an electronic web-based portal by an invited group of participants on two occasions. Results  Interobserver reliability was substantial when classifying AO type A fractures but fair and moderate for type B and C fractures, respectively. No difference was observed by location, except for an apparent difference between participants from India and Australia classifying type B fractures. No statistically significant associations were observed comparing interobserver agreement by level of training and no differences were shown comparing subspecialties. Intra-rater reproducibility was "substantial" for fracture types and "fair" for fracture groups with no difference accounting for location, training level, or specialty. Conclusion  Improved definition of reliability and reproducibility of this classification may be achieved using large international groups of raters, empowering decision making on which system to utilize. Level of Evidence  Level III.

Modeling Speech Level as a Function of Background Noise Level and Talker-to-Listener Distance for Talkers Wearing Hearing Protection Devices

ERIC Educational Resources Information Center

Bouserhal, Rachel E.; Bockstael, Annelies; MacDonald, Ewen; Falk, Tiago H.; Voix, Jérémie

2017-01-01

Purpose: Studying the variations in speech levels with changing background noise level and talker-to-listener distance for talkers wearing hearing protection devices (HPDs) can aid in understanding communication in background noise. Method: Speech was recorded using an intra-aural HPD from 12 different talkers at 5 different distances in 3…

Water storage in marine sediment and implications for inferences of past global ice volume

NASA Astrophysics Data System (ADS)

Ferrier, K.; Li, Q.; Pico, T.; Austermann, J.

2017-12-01

Changes in past sea level are of wide interest because they provide information on the sensitivity of ice sheets to climate change, and thus inform predictions of future sea-level change. Sea level changes are influenced by many processes, including the storage of water in sedimentary pore space. Here we use a recent extension of gravitationally self-consistent sea-level models to explore the effects of marine sedimentary water storage on the global seawater balance and inferences of past global ice volume. Our analysis suggests that sedimentary water storage can be a significant component of the global seawater budget over the 105-year timescales associated with glacial-interglacial cycles, and an even larger component over longer timescales. Estimates of global sediment fluxes to the oceans suggest that neglecting marine sedimentary water storage may produce meter-scale errors in estimates of peak global mean sea level equivalent (GMSL) during the Last Interglacial (LIG). These calculations show that marine sedimentary water storage can be a significant contributor to the overall effects of sediment redistribution on sea-level change, and that neglecting sedimentary water storage can lead to substantial errors in inferences of global ice volume at past interglacials. This highlights the importance of accounting for the influences of sediment fluxes and sedimentary water storage on sea-level change over glacial-interglacial timescales.