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Sample records for gong xin shen

  1. Bu-Shen-Ning-Xin decoction suppresses osteoclastogenesis via increasing dehydroepiandrosterone to prevent postmenopausal osteoporosis.

    PubMed

    Gui, Yuyan; Qiu, Xuemin; Xu, Yingping; Li, Dajin; Wang, Ling

    2015-06-01

    Bu-Shen-Ning-Xin decoction (BSNXD), a traditional Chinese medicine, has been used to prevent and treat age-related diseases such as postmenopausal osteoporosis (PMO) for decades. This study sought to investigate the underlying mechanisms of BSNXD in terms of receptor activation of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis in vitro because of the critical roles of bone resorption in the development and progression of osteoporosis. In mice, serum levels of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and 17-β-estradiol (E2) were evaluated with an enzyme immunoassay kit after ovariectomy. Levels of DHEA and DHEAS increased significantly following administration of BSNXD while the level of E2 did not. In addition, tartrate-resistance acid phosphatase staining showed that DHEA profoundly inhibited RANKL-induced osteoclastogenesis in vitro in a dose-dependent manner via estrogen receptor α (ERα) but not via estrogen receptor β or androgen receptors. Cytotoxicity was not detected in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. These data suggest that BSNXD prevents PMO by increasing DHEA via the ERαpathway to suppress osteoclastogenesis.

  2. Effects of Bu-Shen-Ning-Xin Decoction on immune cells of the spleen and bone marrow in ovariectomized mice.

    PubMed

    Qiu, Xuemin; Gui, Yuyan; Zhang, Na; Xu, Yingping; Li, Dajin; Wang, Ling

    2016-11-15

    Osteoimmunology is a new discipline that focuses on the interaction between the bones and the immune system. Immune cells play an important role in bone metabolism. The aim of this study was to illustrate the effect of Bu-Shen-Ning-Xin Decoction (BSNXD) on lymphocytes in the spleen and bone marrow to explore the potential role on the bone. C57BL/6 mice were divided into four groups: sham, ovariectomized (OVX), OVX+BSNXD, and OVX+ estrogen. The sham and OVX groups were treated with saline, the OVX+BSNXD group was treated with BSNXD, and the OVX+ estrogen group was treated with estrogen. After mice were sacrificed, the spleens and bones were collected, and the lymphocytes in the spleen and bone marrow were analyzed. We found that BSNXD lessened the extent of the increase of CD4(+) and bone marrow. In contrast, these numbers were both increased in the OVX group. BSNXD had no influence on the percentage of γδ T cells. However, it increased the proportion of NK cells in the spleen and bone marrow. BSNXD lessened the extent of the increase of monocytes by ovariectomy. In vitro experiment, we found Tregs can decrease osteoclastogenesis when co-cultured with osteoclast precursor cells. This study suggests that BSNXD changes the immune environment and immune cells have a role in bone metabolism in OVX mice.

  3. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus

    PubMed Central

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Introduction Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported. Purpose We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX) mice to evaluate the efficacy and safety of this herbal formula. Materials and methods Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay. Results BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus. Conclusion These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice. PMID:26357466

  4. Bu-Shen-Ning-Xin Decoction ameliorated the osteoporotic phenotype of ovariectomized mice without affecting the serum estrogen concentration or uterus.

    PubMed

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Bu-Shen-Ning-Xin Decoction (BSNXD), a traditional Chinese medicinal composition, has been used as a remedy for postmenopausal osteoporosis, but its effects on bone metabolism and the uterus have not been reported. We aimed to determine the respective effects of BSNXD on the bones and the uterus of ovariectomized (OVX) mice to evaluate the efficacy and safety of this herbal formula. Postmenopausal osteoporosis animal models that were generated by ovariectomy were treated with BSNXD. Dual-energy X-ray absorptiometry was performed to analyze the bone mineral density, and histomorphometric analysis was performed to measure the parameters related to bone metabolism. Calcein labeling was performed to detect bone formation. The uteruses from the mice were weighed, and the histomorphometry was analyzed. Drug-derived serum was prepared to assess the 17-β-estradiol concentration via enzyme immunoassay. BSNXD administration ameliorated the osteoporotic phenotype of OVX mice, as evidenced by an increase in the bone mineral density and bone volume; these effects could not be abolished by the administration of the aromatase inhibitor letrozole. Moreover, BSNXD had no effect on the serum estrogen concentration or uterus. These results suggest that BSNXD has ameliorating effects on bone loss due to estrogen deprivation without affecting the peripheral blood estrogen concentration or the uterus in OVX mice.

  5. Identification of absorbed constituents and metabolites in rat plasma after oral administration of Shen-Song-Yang-Xin using ultra-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry.

    PubMed

    Shi, Tao; Yao, Zhihong; Qin, Zifei; Ding, Bo; Dai, Yi; Yao, Xinsheng

    2015-09-01

    In this study, a rapid and sensitive method by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, and Metabolynx(TM) software with mass defect filter technique was developed for screening and identification of the metabolites in rat plasma after oral administration of Shen-Song-Yang-Xin capsule (SSYX). A total of 92 SSYX-related xenobiotics were identified or characterized, including 45 prototypes and 47 metabolites. The results indicated that the absorbed constituents and metabolites mainly came from benzocyclooctadiene lignans, tanshinones, isoquinoline alkaloids and triterpenic acids, while phase I reactions (e.g. hydrogenation, hydroxylation, demethylation) and phase II reaction (glucuronidation) were the main metabolic pathways of these ingredients in SSYX. This is the first study on metabolic profiling of SSYX in rat plasma after oral administration. Furthermore, these findings provide useful information on the potential bioactive compounds, and enhance our understanding of the action mechanism of SSYX. Copyright © 2015 John Wiley & Sons, Ltd.

  6. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α

    PubMed Central

    Wang, Ling; Qiu, Xue-Min; Gui, Yu-Yan; Xu, Ying-Ping; Gober, Hans-Jürgen; Li, Da-Jin

    2015-01-01

    Introduction Bu-Shen-Ning-Xin decoction (BSNXD) is a traditional Chinese medicinal composition that has been used as a remedy for postmenopausal osteoporosis, but the mechanisms affecting bone metabolism are not fully understood. Purpose We investigated the molecular mechanism and signaling pathway underlying the effect of BSNXD on osteoclastogenesis. Materials and methods A postmenopausal osteoporosis animal model generated by ovariectomy was administered BSNXD and drug-derived serum was prepared. An enzyme immunoassay was conducted to measure the 17-β-estradiol (E2) concentration in the drug-derived serum. Bone marrow-derived monocyte/macrophage precursor cells were treated with drug-derived serum, and tartrate-resistance acid phosphatase staining was conducted to observe osteoclastogenesis. A bone resorption assay was performed to analyze the effect on osteoclastic resorptive function. Real-time PCR, flow cytometry, Western blotting, transfection, and luciferase assays were conducted to explore the related mechanism. Results E2 was not elevated in BSNXD-derived serum. BSNXD-derived serum suppressed receptor activation of nuclear factor κB ligand (RANKL)-activated osteoclastogenesis in a dose-dependent manner; this effect could be reversed by estrogen receptor α antagonist methyl-piperidino-pyrazole. The serum suppressed RANKL-induced NF-κB transcription and inhibited the accumulation of nuclear factor of activated T-cells, cytoplasmic 1 in osteoclast precursor cells; the inhibitory effect was abolished by methyl-piperidino-pyrazole but not the estrogen receptor β antagonist or androgen receptor antagonist. Conclusion These results collectively suggest that administration of BSNXD presents inhibitory effects on osteoclast differentiation by abrogating the RANKL-induced nuclear factor of activated T-cells, cytoplasmic 1 and NF-κB signaling pathways downstream of estrogen receptor α, thereby contributing to the inhibitory effect on bone resorption. PMID

  7. Automating GONG's Angle Determination Pipeline

    NASA Astrophysics Data System (ADS)

    Toner, C. G.

    2005-05-01

    Recently, GONG started recording regular noon drift-scans throughout the Network (3 per week). This is in an effort to prevent spurious "wobbling" of GONG's merged images by providing regular "reality checks" on the true orientation of the site images. Wobbling can be very detrimental to local helioseismology analyses (A.K.A. the "Washing Machine Effect") Here we describe recent steps to automate the processing of the drift-scans once they arrive in Tucson.

  8. Quake Detection Using MDI and GONG Data

    NASA Astrophysics Data System (ADS)

    Zharkov, S.; Zharkova, V. V.; Matthews, S. A.

    2010-12-01

    We compare the results of sunquake detection from high-cadence observations of dopplergrams and intensities obtianed by GONG and SOHO/MDI. The two methods: acoustic holography and time-distance diagrams, are used to investigate three well-known acoustically active flares: M-class September 9, 2001, and two X-class flares on October 28 and 29, 2003. We show that in spite of the GONG data being subject to atmospheric effects such as smearing, with the correction suggested in Lindsey Donea 2008 combined with the additional processing procedures, the GONG data can be used for a confident sunquake detection.

  9. The Global Oscillation Network Group (GONG) Project

    PubMed

    Harvey; Hill; Hubbard; Kennedy; Leibacher; Pintar; Gilman; Noyes; Title; Toomre; Ulrich; Bhatnagar; Kennewell; Marquette; Patron; Saa; Yasukawa

    1996-05-31

    Helioseismology requires nearly continuous observations of the oscillations of the solar surface for long periods of time in order to obtain precise measurements of the sun's normal modes of oscillation. The GONG project acquires velocity images from a network of six identical instruments distributed around the world. The GONG network began full operation in October 1995. It has achieved a duty cycle of 89 percent and reduced the magnitude of spectral artifacts by a factor of 280 in power, compared with single-site observations. The instrumental noise is less than the observed solar background.

  10. Resilience Linguistics, Orthography and the Gong

    ERIC Educational Resources Information Center

    Bradley, David

    2011-01-01

    The Gong are a minority group of western Thailand whose language has been in decline for over a century. In the 1920s, the first report of the language predicted its imminent demise. Since then, it has contacted to two villages outside its traditional territory. The language there is under threat, particularly since the 1970s with roads, schools,…

  11. Resilience Linguistics, Orthography and the Gong

    ERIC Educational Resources Information Center

    Bradley, David

    2011-01-01

    The Gong are a minority group of western Thailand whose language has been in decline for over a century. In the 1920s, the first report of the language predicted its imminent demise. Since then, it has contacted to two villages outside its traditional territory. The language there is under threat, particularly since the 1970s with roads, schools,…

  12. GONG Inter-site Hα Flare Comparison

    NASA Astrophysics Data System (ADS)

    Giersch, Owen

    2013-06-01

    A challenge of the past few decades for the Solar Observing Optical Network (SOON), operated by the United States Air Force Weather Agency (AFWA), has been to obtain consistent flare brightness reporting for the same flare from different sites. Flare area is usually considered to be a more reliable measure, but significant variation of values between sites still occurs. The Global Oscillation Network Group (GONG) deployed a Hα patrol system in 2010. This provides a modern system with near identical equipment to compare flares from six different sites. The classification of flares and techniques of flare measurement will be briefly discussed. The results presented here suggest that even though different GONG sites report different flare areas and brightnesses, for some sites they vary in a consistent way allowing correction factors to be applied.

  13. Unique changes found on the Qi Gong (Chi Gong) Master's and patient's body during Qi Gong treatment; their relationships to certain meridians & acupuncture points and the re-creation of therapeutic Qi Gong states by children & adults.

    PubMed

    Omura, Y; Lin, T L; Debreceni, L; Losco, B M; Freed, S; Muteki, T; Lin, C H

    1989-01-01

    Changes taking place in both Qi Gong Masters and their patients during Qi Gong treatment were evaluated using the Bi-Digital O-Ring Test. During the Qi Gong state, on the Qi-Gong Master's body, as well as the body of the patient being treated, acupuncture points CV5 (Shi Men) and CV6 (Qi Hai)-- located below the umbilicus-- show changes from +4 in the pre-Qi Gong state to between -3 and -4 during the Qi Gong state. Before and after the Qi Gong, there is a normal +4 response to the Bi-Digital O-Ring Test at these acupuncture points. Similar changes were also observed on acupuncture points CV17 (Shan Zhong), CV 22 (Tian Tu), Yin Tang (at an area just between the eyebrows: the pituitary gland representation area, colloquially known as the "third eye") and GV20(Bai Hui), the entire pericardium meridian & triple burner meridian, their acupuncture points, the adrenal glands, testes, ovaries and perineum, as well as along the entire spinal vertebrae, particularly on and above the 12th thoracic vertebra, medulla oblongata, pons, and the intestinal representation areas of the brain located just above and behind the upper ear. Using these findings as criteria for evaluating the effectiveness of reaching the Qi Gong state, we were able to reproduce during the experimental trials similar changes in ourselves and the patient being treated with therapeutic effects comparable to those of the Qi Gong Master. Beneficial effects of external Qi Gong treatment given by a Qi Gong practitioner 1 to 3 times for 10-20 seconds each (although most Qi Gong masters take 3-20 minutes per treatment) often resulted in improvement of circulation and lowering of high blood pressure, as well as relaxation of spastic muscles, relief of pain, and enhanced general well-being, all of which resemble acupuncture effects. In order to reproduce the same procedure with others, we selected 4 children ranging between 8 and 11 years of age who had no knowledge of Qi Gong or Oriental medicine. One of these four

  14. Thermography applied acupuncture and qi-gong

    NASA Astrophysics Data System (ADS)

    Qin, Yuwen; Ji, Hong-Wei; Chen, Jin-Long; Li, Hong-Qi

    1997-04-01

    Thermographic technique can be used to measure temperature distribution of body surface in real-time, non-contact and full-field, which has been successfully used in medical diagnosis, remote sensing, and NDT, etc. The authors have developed a thermographic experiment that can be applied to inspect the effect of action of acupuncture and qi-gong (a system of deep breathing exercises) by measuring the temperature of hand and arm. The observation is performed respectively by thermography for the dynamic changes of temperature of the arm and hand after acupuncture therapy and qi-gong therapy. Thermographic results show that the temperature on the collateral channels increases markedly. In the meantime, it can be seen that the above therapies of Chinese medicine can stimulate the channel collateral system. This also contributes a new basis to the effect of action of the therapies of Chinese medicine. The work shows that thermographic technique is a powerful tool for research in Chinese medicine. In this paper, some thermal images are obtained from the persons treated with acupuncture and qi- gong.

  15. The sociology of Qi Gong: a qualitative study.

    PubMed

    Posadzki, Paul

    2010-04-01

    This paper presents an in-depth, idiographic study of how individuals experience others during Qi Gong practice. Semi-structured interviews were conducted with three Qi Gong groups to collect research data. These data were transcribed verbatim and subjected to content and thematic analysis across and within groups. The analysis indicates extraordinary experiences of Qi Gong practitioners at various levels of their social functioning. Qi Gong influences their social health in complex and \\dimensional ways. The author compares and contrasts his results with those of recent research. Implications for practice are briefly outlined and possible strategies for future research are presented. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  16. Normal modes of a small gamelan gong.

    PubMed

    Perrin, Robert; Elford, Daniel P; Chalmers, Luke; Swallowe, Gerry M; Moore, Thomas R; Hamdan, Sinin; Halkon, Benjamin J

    2014-10-01

    Studies have been made of the normal modes of a 20.7 cm diameter steel gamelan gong. A finite-element model has been constructed and its predictions for normal modes compared with experimental results obtained using electronic speckle pattern interferometry. Agreement was reasonable in view of the lack of precision in the manufacture of the instrument. The results agree with expectations for an axially symmetric system subject to small symmetry breaking. The extent to which the results obey Chladni's law is discussed. Comparison with vibrational and acoustical spectra enabled the identification of the small number of modes responsible for the sound output when played normally. Evidence of non-linear behavior was found, mainly in the form of subharmonics of true modes. Experiments using scanning laser Doppler vibrometry gave satisfactory agreement with the other methods.

  17. GONG Observations of Solar Surface Flows

    PubMed

    Hathaway; Gilman; Harvey; Hill; Howard; Jones; Kasher; Leibacher; Pintar; Simon

    1996-05-31

    Doppler velocity observations obtained by the Global Oscillation Network Group (GONG) instruments directly measure the nearly steady flows in the solar photosphere. The sun's differential rotation is accurately determined from single observations. The rotation profile with respect to latitude agrees well with previous measures, but it also shows a slight north-south asymmetry. Rotation profiles averaged over 27-day rotations of the sun reveal the torsional oscillation signal-weak, jetlike features, with amplitudes of 5 meters per second, that are associated with the sunspot latitude activity belts. A meridional circulation with a poleward flow of about 20 meters per second is also evident. Several characteristics of the surface flows suggest the presence of large convection cells.

  18. Nearly steady flows in GONG prototype data

    NASA Technical Reports Server (NTRS)

    Hathaway, David H.

    1993-01-01

    Doppler velocity images obtained with the GONG prototype instrument were analyzed to measure the nearly steady photospheric flows. The data consists of 88 images each of velocity, intensity, and modulation obtained at 20:00 UT on 88 days from July 1992 to February 1994. Each velocity image was temporally filtered to remove the p-mode oscillations, masked to exclude active regions, and then analyzed using spherical harmonics and orthogonal functions as described by Hathaway (1992). The spectral coefficients show very consistent results for the entire time interval with some evidence of year-to-year variations. The rotation profile agrees well with previous results and exhibits a north-south asymmetry that reverses sign during the 20 month interval. The residual rotation velocities exhibit structures with amplitudes of approximately 5 m/s that may be related to torsional oscillations. The meridional circulation is directed from the equator toward the poles with a peak velocity in the photosphere of approximately 50 m/s. The higher order components are very weak but indicate a divergent flow from the mid-latitudes (opposite that found for the June 1989 data). The convective limb shift is well fit by a 3rd order polynomial. The convection spectrum has a prominent peak at spherical harmonic degrees of l approximately 150 with very little signal in the low degree modes. Analysis of this signal shows that there is no evidence for giant cell convection at the level of approximately 10 m/s for all modes up to l = 32.

  19. Emergence of Xin demarcates a key innovation in heart evolution.

    PubMed

    Grosskurth, Shaun E; Bhattacharya, Debashish; Wang, Qinchuan; Lin, Jim Jung-Ching

    2008-08-06

    The mouse Xin repeat-containing proteins (mXinalpha and mXinbeta) localize to the intercalated disc in the heart. mXinalpha is able to bundle actin filaments and to interact with beta-catenin, suggesting a role in linking the actin cytoskeleton to N-cadherin/beta-catenin adhesion. mXinalpha-null mouse hearts display progressively ultrastructural alterations at the intercalated discs, and develop cardiac hypertrophy and cardiomyopathy with conduction defects. The up-regulation of mXinbeta in mXinalpha-deficient mice suggests a partial compensation for the loss of mXinalpha. To elucidate the evolutionary relationship between these proteins and to identify the origin of Xin, a phylogenetic analysis was done with 40 vertebrate Xins. Our results show that the ancestral Xin originated prior to the emergence of lamprey and subsequently underwent gene duplication early in the vertebrate lineage. A subsequent teleost-specific genome duplication resulted in most teleosts encoding at least three genes. All Xins contain a highly conserved beta-catenin-binding domain within the Xin repeat region. Similar to mouse Xins, chicken, frog and zebrafish Xins also co-localized with beta-catenin to structures that appear to be the intercalated disc. A putative DNA-binding domain in the N-terminus of all Xins is strongly conserved, whereas the previously characterized Mena/VASP-binding domain is a derived trait found only in Xinalphas from placental mammals. In the C-terminus, Xinalphas and Xinbetas are more divergent relative to each other but each isoform from mammals shows a high degree of within-isoform sequence identity. This suggests different but conserved functions for mammalian Xinalpha and Xinbeta. Interestingly, the origin of Xin ca. 550 million years ago coincides with the genesis of heart chambers with complete endothelial and myocardial layers. We postulate that the emergence of the Xin paralogs and their functional differentiation may have played a key role in the

  20. Comparison of GONG and MDI solar p-mode background

    NASA Astrophysics Data System (ADS)

    Barban, C.; Hill, F.

    2004-04-01

    Using Severino's model, we estimate the amount of coherent correlated and uncorrelated background and incoherent noise components needed to reproduce the following four helioseismic spectra: V power, I power, V I phase difference and V I coherence, using GONG and MDI data. We confirm that a coherent correlated component of 10-15% of the total background and noise is needed in both V and I and that a larger amount of coherent uncorrelated background is needed for MDI data compared to GONG data to compensate for a smaller incoherent noise.

  1. [Traditional immunosuppression--Lei Gong Teng in modern medicine].

    PubMed

    Caspi, Opher; Polak, Arik

    2013-07-01

    Although the origin of many common modern medicines that are routinely being used nowadays in healthcare is in medicinal plants and fungi, herbal medicine as a standalone profession is no longer included in the curricula of most Western medical schools. The medicinal plant Lei Gong Teng [also known as Thunder God Vine, Tripterygium Wilfordii Hook f., that is core to traditional Chinese herbal medicine, was praised for its possible anti-inflammatory properties in ancient traditional scripts that date back thousands of years. Yet, modern interest in its proven immune-modulatory properties serves as a vivid example to the bridge that is being built, gradually but constantly, between the tradition of healing arts and the world of modern therapeutics. In this review we summarize the main findings from an increasing number of clinical and laboratory studies published in top peer-reviewed medical journals that verify the traditional indications for which Lei Gong Teng was used medicinally. Based on these findings, and the risk-benefit profile of the plant's debarked root, we conclude that Lei Gong Teng and its active metabolites should be included in the Israeli herbal pharmacopeia.

  2. Localization and function of Xinα in mouse skeletal muscle.

    PubMed

    Feng, Han-Zhong; Wang, Qinchuan; Reiter, Rebecca S; Lin, Jenny L-C; Lin, Jim J-C; Jin, J-P

    2013-05-15

    The Xin repeat-containing proteins were originally found in the intercalated discs of cardiac muscle with implicated roles in cardiac development and function. A pair of paralogous genes, Xinα (Xirp1) and Xinβ (Xirp2), is present in mammals. Ablation of the mouse Xinα (mXinα) did not affect heart development but caused late-onset adulthood cardiac hypertrophy and cardiomyopathy with conductive defects. Both mXinα and mXinβ are also found in the myotendinous junction (MTJ) of skeletal muscle. Here we investigated the structural and functional significance of mXinα in skeletal muscle. In addition to MTJ and the contact sites between muscle and perimysium, mXinα but not mXinβ was found in the blood vessel walls, whereas both proteins were absent in neuromuscular junctions and nerve fascicles. Coimmunoprecipitation suggested association of mXinα with talin, vinculin, and filamin, but not β-catenin, in adult skeletal muscle, consistent with our previous report of colocalization of mXinα with vinculin. Loss of mXinα in mXinα-null mice had subtle effects on the MTJ structure and the levels of several MTJ components. Diaphragm muscle of mXinα-null mice showed hypertrophy. Compared with wild-type controls, mouse extensor digitorum longus (EDL) muscle lacking mXinα exhibited no overt change in contractile and relaxation velocities or maximum force development but better tolerance to fatigue. Loaded fatigue contractions generated stretch injury in wild-type EDL muscle as indicated by a fragmentation of troponin T. This effect was blunted in mXinα-null EDL muscle. The results suggest that mXinα play a role in MTJ conductance of contractile and stretching forces.

  3. Localization and function of Xinα in mouse skeletal muscle

    PubMed Central

    Feng, Han-Zhong; Wang, Qinchuan; Reiter, Rebecca S.; Lin, Jenny L.-C.; Lin, Jim J.-C.

    2013-01-01

    The Xin repeat-containing proteins were originally found in the intercalated discs of cardiac muscle with implicated roles in cardiac development and function. A pair of paralogous genes, Xinα (Xirp1) and Xinβ (Xirp2), is present in mammals. Ablation of the mouse Xinα (mXinα) did not affect heart development but caused late-onset adulthood cardiac hypertrophy and cardiomyopathy with conductive defects. Both mXinα and mXinβ are also found in the myotendinous junction (MTJ) of skeletal muscle. Here we investigated the structural and functional significance of mXinα in skeletal muscle. In addition to MTJ and the contact sites between muscle and perimysium, mXinα but not mXinβ was found in the blood vessel walls, whereas both proteins were absent in neuromuscular junctions and nerve fascicles. Coimmunoprecipitation suggested association of mXinα with talin, vinculin, and filamin, but not β-catenin, in adult skeletal muscle, consistent with our previous report of colocalization of mXinα with vinculin. Loss of mXinα in mXinα-null mice had subtle effects on the MTJ structure and the levels of several MTJ components. Diaphragm muscle of mXinα-null mice showed hypertrophy. Compared with wild-type controls, mouse extensor digitorum longus (EDL) muscle lacking mXinα exhibited no overt change in contractile and relaxation velocities or maximum force development but better tolerance to fatigue. Loaded fatigue contractions generated stretch injury in wild-type EDL muscle as indicated by a fragmentation of troponin T. This effect was blunted in mXinα-null EDL muscle. The results suggest that mXinα play a role in MTJ conductance of contractile and stretching forces. PMID:23485711

  4. Transitioning GONG data processing to NOAA SWPC operations

    NASA Astrophysics Data System (ADS)

    Reinard, A.; Marble, A.; Hill, F.; Berger, T. E.

    2015-12-01

    The NOAA Space Weather Prediction Center (SWPC) is the nation's official source of space weather watches, warnings, and alerts, providing 24x7 forecasting and support to critical infrastructure operators around the world. Observations of the conditions on the Sun are crucial for determining when and if a warning is needed. The Global Oscillation Network Group (GONG) operated by the National Solar Observatory (NSO) consists of six ground stations, allowing continuous observations of the Sun. Of particular interest for space weather purposes are the H-alpha images and magnetograms. The H-alpha data are used to identify filaments and their eruptions, to assess active region evolution and plage extent, and to help localize flare locations. The magnetograms are used to identify neutral lines, to examine potential shearing areas and to characterize the magnetic structure of active regions. GONG magnetograms also provide the initial condition for models of solar wind expansion through the heliosphere such as the WSA-Enlil model. Although beyond the scope of current space weather applications, GONG helioseismology products can be used to assess active region emergence on the far side of the Sun and to indicate the flaring potential of a front-side active region. These products are being examined as future tools in flare prediction. NSO has operated GONG as a science facility since 1995 and has provided processed space weather data products to NOAA via public internet connections for the past several years. In 2014 the White House Office of Management and Budget (OMB) requested that NOAA transition the GONG network to an operational space weather asset in order to ensure the continued flow of critical magnetogram data for solar wind models. NSO will continue to operate and manage the instruments and sites, but the H-alpha images and 10 minute averaged magnetogram data will be sent directly to SWPC for processing and use in space weather modeling. SWPC will make these data

  5. Transitioning GONG data processing to NOAA SWPC operations

    NASA Astrophysics Data System (ADS)

    Reinard, Alysha; Marble, Andrew R.; Berger, Thomas

    2016-05-01

    The NOAA Space Weather Prediction Center (SWPC) is the nation's official source of space weather watches, warnings, and alerts, providing 24x7 forecasting and support to critical infrastructure operators around the world. Observations of the conditions on the Sun are crucial for determining when and if a warning is needed. The Global Oscillation Network Group (GONG) operated by the National Solar Observatory (NSO) consists of six ground stations, allowing continuous observations of the Sun. Of particular interest for space weather purposes are the H-alpha images and magnetograms. The H-alpha data are used to identify filaments and their eruptions, to assess active region evolution and plage extent, and to help localize flare locations. The magnetograms are used to identify neutral lines, to examine potential shearing areas and to characterize the magnetic structure of active regions. GONG magnetograms also provide the initial condition for models of solar wind expansion through the heliosphere such as the WSA-Enlil model. Although beyond the scope of current space weather applications, GONG helioseismology products can be used to assess active region emergence on the far side of the Sun and to indicate the flaring potential of a front-side active region. These products are being examined as future tools in flare prediction.NSO has operated GONG as a science facility since 1995 and has provided processed space weather data products to NOAA via for the past several years. In 2014 the White House Office of Management and Budget (OMB) requested that NOAA transition the GONG network to an operational space weather asset in order to ensure the continued flow of critical data for solar wind models. NSO will continue to operate and manage the instruments and sites, but the H-alpha images and 10 minute averaged magnetogram data will be sent directly to SWPC for processing and use in space weather modeling. SWPC will make these data available to NSO and the public via the

  6. Full-disk Solar H-alpha Images From GONG

    NASA Astrophysics Data System (ADS)

    Harvey, J. W.; Bolding, J.; Clark, R.; Hauth, D.; Hill, F.; Kroll, R.; Luis, G.; Mills, N.; Purdy, T.; Henney, C.; Holland, D.; Winter, J.

    2011-05-01

    Since mid-2010 the Global Oscillation Network Group (GONG) has collected H-alpha images at six sites around the world. These images provide a near real-time solar activity patrol for use in space weather applications and also an archive for research purposes. Images are collected once per minute, dark, smear, and flat corrected, compressed and then sent via the Internet to a 'cloud' server where reduction is completed. Various reduced images are usually available within a minute after exposure. The H-alpha system is an add-on to the normal GONG helioseismology instrument and does not interfere with regular observations. A polarizing beamsplitter sends otherwise unused 656 nm light through two lenses to a Daystar 0.04 nm mica etalon filter. The filter is matched to an image of the GONG light feed entrance pupil and sees an image of the Sun at infinity. Two lenses behind the filter form the solar image on a DVC-4000 2k x 2k interline transfer CCD camera. Exposure times are automatically adjusted to maintain the quiet disk center at 20% of full dynamic range to avoid saturation by bright flares. Image resolution is limited by diffraction, seeing and some high-order wavefront errors in the filters. A unique dual-heater system was developed by Daystar to homogenize the passband characteristics of the mica etalons. The data are in regular use for space weather forecasting by the U.S. Air Force Weather Agency, which funded construction and installation of the instruments. Operational and reduction improvements are underway and archived data are already being used for research projects. The Web site URL is http://halpha.nso.edu.

  7. Doing Ideology amid a Crisis: Collective Actions and Discourses of the Chinese Falun Gong Movement

    ERIC Educational Resources Information Center

    Chan, Cheris Shun-ching

    2013-01-01

    Based on an interactionist framework, this article examines how followers of a contemporary Chinese religious movement, Falun Gong, deal with a crisis situation and sustain their conviction in the absence of their charismatic leader. Data were collected during a yearlong ethnography of the Falun Gong in Chicago and Hong Kong. The findings reveal…

  8. Yu-Gong Yi Shan: Exploring Some Possibilities of Designing Tomorrow's Foreign Language Textbook.

    ERIC Educational Resources Information Center

    Chan, Chung; Liu, Li-chia

    1992-01-01

    An electronic version of Yu-gong Yi Shan, an ancient Chinese fable, is discussed as a prototype of the use of technology for Chinese teaching and learning. Yu-gong demonstrates how hypermedia can be designed to overcome the linear, static, and silent constraints of book technology. (four references) (Author/LB)

  9. Doing Ideology amid a Crisis: Collective Actions and Discourses of the Chinese Falun Gong Movement

    ERIC Educational Resources Information Center

    Chan, Cheris Shun-ching

    2013-01-01

    Based on an interactionist framework, this article examines how followers of a contemporary Chinese religious movement, Falun Gong, deal with a crisis situation and sustain their conviction in the absence of their charismatic leader. Data were collected during a yearlong ethnography of the Falun Gong in Chicago and Hong Kong. The findings reveal…

  10. Preliminary discussion on the origin of Lei-gong-mo (tektites)

    NASA Technical Reports Server (NTRS)

    Baoyin, Y.

    1983-01-01

    The specimens of lei-gong-mo (tektites) were collected from Hainan Island and Leizhow Peninsula during the period from 1963 to 1975. The distribution, forms, sculpture, abration surface (bald spot), internal structure and chemical composition of lei-gong-mo are discussed. Studies of these materials lead to the following conclusions: (1) the specimens of lei-gong-mo can be morphologically divided into eight types; (2) the sculptures on the surface of lei-gong-mo are probably due to the corrosion effect of volcanic gas, and the abration surface due to the aerodynamic corrosion; (3) the folded structures in the layered lei-gong-mo (Muong Nong-type tektite) seem hardly to be formed by an impact of meteorites, but they might be produced in the magma flow process when the lei-gong-mo was melting within the crater vent; and (4) the comparison of its chemical composition with that of basalt from Hainan Island does not show that lei-gong-mo came from the local volcano. The hypothesis of the lunar volcanic origin of tektites is examined.

  11. Skeletal muscle regeneration is delayed by reduction in Xin expression: consequence of impaired satellite cell activation?

    PubMed

    Nissar, Aliyah A; Zemanek, Bart; Labatia, Rita; Atkinson, Daniel J; van der Ven, Peter F M; Fürst, Dieter O; Hawke, Thomas J

    2012-01-01

    Xin is a striated muscle-specific actin-binding protein whose mRNA expression has been observed in damaged skeletal muscle. Here we demonstrate increased Xin protein expression early postinjury (≤ 12 h) and localization primarily to the periphery of damaged myofibers. At 1 day postinjury, Xin is colocalized with MyoD, confirming expression in activated satellite cells (SCs). By 5 days postinjury, Xin is evident in newly regenerated myofibers, with a return to preinjury levels by 14 days of regeneration. To determine whether the increased Xin expression is functionally relevant, tibialis anterior muscles of wild-type mice were infected with Xin-short hairpin RNA (shRNA) adenovirus, whereas the contralateral tibialis anterior received control adenovirus (Control). Four days postinfection, muscles were harvested or injured with cardiotoxin and collected at 3, 5, or 14 days thereafter. When compared with Control, Xin-shRNA infection attenuated muscle regeneration as demonstrated by Myh3 expression and fiber areas. Given the colocalization of Xin and MyoD, we isolated single myofibers from infected muscles to investigate the effect of silencing Xin on SC function. Relative to Control, SC activation, but not proliferation, was significantly impaired in Xin-shRNA-infected muscles. To determine whether Xin affects the G0-G1 transition, cell cycle reentry was assessed on infected C2C12 myoblasts using a methylcellulose assay. No difference in reentry was noted between groups, suggesting that Xin contributes to SC activation by means other than affecting G0-G1 transition. Together these data demonstrate a critical role for Xin in SC activation and reduction in Xin expression results in attenuated skeletal muscle repair.

  12. [Contraindications of spirit (shen) in acupuncture and moxibustion].

    PubMed

    Ji, Zheng-Han; Yan, Ji-Lan; Wang, Shu-Bin; Zu, Na

    2014-07-01

    ABSTRACT The taboos of man-spirit (RenShen) and bottom-spirit (KaoShen) are two kinds of time-related contraindications that are more commonly seen in the literature of acupuncture and moxibustion. The meaning of man-spirit is often extended to qi-blood or mind, or else directly equals to heaven-spirit (TianShen). It is highly possible that the bottom-spirit is subordinate to man-spirit, and both Taoist philosophy and the SanCai theory declare the importance of bottom in human body. The violation of contraindications could lead to diseases in the neighborhood where man-spirit travels. However, the results are generally recorded as ulcer, lingering disease and death in most medical texts. From Ming dynasty, more and more doctors have expressed disapproval of man-spirit and bottom-spirit.

  13. Jin–Xin relaxation solution to the spatially-varying Burgers equation in one dimension

    NASA Astrophysics Data System (ADS)

    Mungkasi, Sudi; Laras, Fioretta

    2017-01-01

    We consider the spatially-varying Burgers equation in one dimension. We take the Lax–Friedrichs finite volume method and Jin–Xin relaxation method in solving the equation. According to our research, the Jin–Xin relaxation method produces a more accurate solution, as they produce smaller error than the Lax–Friedrichs finite volume method. However, the Lax–Friedrichs finite volume method is faster in computation than the Jin–Xin method.

  14. [The cultural and medical significance of Xin an mingzuzhi(History of Famous Family in Xin'an)].

    PubMed

    Hu, A H; Wan, S M

    2016-01-28

    History of Famous Family in Xin'an includes abundant information and important value of the medical cultural history, including the medical family, medical ethics and the number of the famous doctors and its distribution, the medical books and its outline the medical ethics, the diseases. As for the 115 famous doctors recorded in this book, Shexian county owns the most while Jixi county owns the least, and of the average number of famous doctors among the 10, 000 local people, Yixian county owns the most while Xiuning county owns the least. History of Famous Family in Xin'an includes 26 medical books, ranging from medical literature study, gynecological treatment, external medical treatment, diagnosis and treatment of pediatric diseases, ancient medical case records, medical education, acu-moxibustion and summary of other medical experiences. The book also demonstrates the noble morality of doctors, development of doctor' family, and records of paralytic stroke, epistaxis, tuberculous consumptive diseases, furunculosis, dystocia and some infectious diseases.

  15. Qi Gong exercises and Feldenkrais method from the perspective of Gestalt concept and humanistic psychology.

    PubMed

    Posadzki, Paul; Stöckl, Andrea; Mucha, Dariusz

    2010-07-01

    This study describes two similar approaches to human movement: Qi Gong exercises and the Feldenkrais method. These systems are investigated in terms of Gestalt concepts and humanistic psychology. Moshe Feldenkrais created the concept known as Awareness Through Movement. This concept assumes that by becoming more aware of one's movements, one functions at a higher level. In similar ways to those using the Feldenkrais method, individuals may become more aware of their own movements by performing Qi Gong exercises: A therapeutic modality that facilitates mind-body integration. Qi Gong exercises commonly lead to increased personal awareness accompained by enhanced quality, fluency and smoothness of movement. These two methods of movement therapies are explored in terms of their relations with Gestalt concept and humanistic psychology.

  16. Chemical characterization of Magnolia biondii (Flos Magnoliae, Xin Yi).

    PubMed

    Schühly, Wolfgang; Skarbina, Jeannette; Kunert, Olaf; Nandi, Owi I; Bauer, Rudolf

    2009-02-01

    Samples of Magnolia biondii buds (Xin Yi, Flos Magnoliae) from different sources were subjected to phytochemical analysis and compared to samples of M. denudata and M. liliiflora. Among the compounds found in the flower buds of M. biondii were eight tetrahydrofurofuran lignans as well as the sesquiterpene lactone parthenolide and the sesquiterpene alcohol oplodiol. A rapid TLC-method for the identification of plant material from M. biondii and its distinction from M. liliiflora was developed. Structure elucidation was carried out by means of NMR (1- and 2-D) and LC-MS.

  17. Analyzing a Social Movement's Use of Internet: Resource Mobilization, New Social Movement Theories and the Case of Falun Gong

    ERIC Educational Resources Information Center

    Huang, Bi Yun

    2009-01-01

    Falun Gong emerged as spiritual social movement after being outlawed by the Chinese Communist Party authorities in 1999. Since then, Falun Gong practitioners have made heavy use of information and communication technologies, particularly the Internet, to further their movement's activities. This dissertation systematically examines the role of…

  18. Analyzing a Social Movement's Use of Internet: Resource Mobilization, New Social Movement Theories and the Case of Falun Gong

    ERIC Educational Resources Information Center

    Huang, Bi Yun

    2009-01-01

    Falun Gong emerged as spiritual social movement after being outlawed by the Chinese Communist Party authorities in 1999. Since then, Falun Gong practitioners have made heavy use of information and communication technologies, particularly the Internet, to further their movement's activities. This dissertation systematically examines the role of…

  19. Ultra Low-Frequency Oscillations of a Solar Filament Observed by the GONG Network

    NASA Astrophysics Data System (ADS)

    Efremov, V. I.; Parfinenko, L. D.; Solov'ev, A. A.

    2016-11-01

    The data of ground-based telescopes of the Global Oscillation Network Group (GONG) obtained in the Hα line provide an opportunity to study the long-period oscillations of chromospheric filaments (quiescent prominences). For the first time, on the basis of time series of 5 days duration that we combined from the observations of three observatories of the GONG network, a new ultra-low mode with a period of between 20 and 30 hours was reliably detected in oscillations of a long-lived dark filament on the solar disk.

  20. Comparison of Time-Distance Local Helioseismology on GONG and MDI Data Sets

    NASA Technical Reports Server (NTRS)

    Duvall, T. L., Jr.; Zhao, J.; Rajaguru, S. P.; Toner, C. G.; Kosovichev, A. G.; Thompson, M. J.; Hughes, S. J.

    2003-01-01

    We show first results derived from one rotation of GONG++ and MDI data analyzed independently by different groups with time-distance techniques. We focus on observations obtained during spring 2002 and especially on Carrington rotation 1988 (2002/3/30 - 2002/4/26) and measure flow components and wave speed inhomogeneities over a range of depths for different active regions.

  1. COMPARISON OF SEISMIC SIGNATURES OF FLARES OBTAINED BY SOHO/MICHELSON DOPPLER IMAGER AND GONG INSTRUMENTS

    SciTech Connect

    Zharkov, S.; Matthews, S. A.; Zharkova, V. V.

    2011-10-01

    The first observations of seismic responses to solar flares were carried out using time-distance (TD) and holography techniques applied to SOHO/Michelson Doppler Imager (MDI) Dopplergrams obtained from space and unaffected by terrestrial atmospheric disturbances. However, the ground-based network GONG is potentially a very valuable source of sunquake observations, especially in cases where space observations are unavailable. In this paper, we present an updated technique for pre-processing of GONG observations for the application of subjacent vantage holography. Using this method and TD diagrams, we investigate several sunquakes observed in association with M- and X-class solar flares and compare the outcomes with those reported earlier using MDI data. In both GONG and MDI data sets, for the first time, we also detect the TD ridge associated with the 2001 September 9 flare. Our results show reassuringly positive identification of sunquakes from GONG data that can provide further information about the physics of seismic processes associated with solar flares.

  2. Students Learn about Chinese Culture through the Folktale "Yeh-Shen": Emphasizing Figurative Language Interpretation

    ERIC Educational Resources Information Center

    Palmer, Barbara C.; Sun, Lingzhi; Leclere, Judith T.

    2012-01-01

    This article will analyze the figurative language that reflects Chinese traditional society and culture in "Yeh-Shen." The authors will consider both the figures of speech and the figures of thought (to include symbolism) that provide insight into an understanding of the Chinese culture through a reading of "Yeh-Shen." This analysis can be used by…

  3. Jin–Xin relaxation method for solving a traffic flow problem in one dimension

    NASA Astrophysics Data System (ADS)

    Ambar Sulistiyawati, Bernadetta; Mungkasi, Sudi

    2017-01-01

    We test the performance of the Jin–Xin relaxation and Lax–Friedrichs finite volume numerical methods in solving a traffic flow problem. In particular, we focus on traffic flow at a traffic light turning from red to green. Numerical solutions are compared with the analytical solution to the mathematical model. We find that the Jin–Xin relaxation solution is more accurate than the Lax–Friedrichs finite volume solution.

  4. [Contributions of medical practitioners of Xin'an area on acupuncture theory].

    PubMed

    Hu, Ling; Tang, Wei; Wu, Zi-Jian; Liu, Guang-Xia; Niu, Shu-Ping; Bai, Liang-Chuan; Chen, Wei-Hua; Xia, Xiao-Hong; Hu, Wu-Bin

    2012-08-01

    Contributions of Xin'an medical school and physicians to acupuncture theory were introduced in the article. Academic theories or characteristics of several physicians of Xin'an school such as YANG Xuan-cao, WU Kun, WANG Ji, WU Yi-ding, ZHENG Mei-jian and XU Chun-fu, et al were sorted out. Contributions of inheriting and illustrations on acupuncture theory were analyzed so as to expound its significance and value on modern acupucture clinic.

  5. [Research on Zhang's collated edition of Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica)].

    PubMed

    Cheng, Li

    2010-05-01

    Lei gong pao zhi lun (Master Lei's Discourse on Processing of Chinese Materia Medica) collated by Zhang Ji, and printed by Zhang's Yisheng Tang in Chengdu in 1932 was the first collated edition. Its original edition was not Jing shi zheng lei bei ji ben cao (Classified Materia Medica from Historical Classics for Emergency) of the Song Dynasty, but was Xiu shi zhi nan (Instruction for Drug Processing) and Lei gong pao zhi yao xing jie (Explanation on Master Lei's Properties of Drugs Processing) of the Qing Dynasty. The contents of this collated edition was far from Lei gong pao zhi lun with many mistakes, and was not the best edition to study Lei gong pao zhi lun.

  6. Subsurface Zonal and Meridional Flow Derived from GONG and SDO/HMI: A Comparison of Systematics

    NASA Astrophysics Data System (ADS)

    Komm, R.; González Hernández, I.; Howe, R.; Hill, F.

    2015-04-01

    We study the subsurface flows in the near-surface layers of the solar convection zone from the surface to a depth of 16 Mm derived from Global Oscillation Network Group (GONG) and Helioseismic and Magnetic Imager (HMI) Dopplergrams using a ring-diagram analysis. We characterize the systematic east-west and north-south variations present in the zonal and meridional flows and compare flows derived from GONG and HMI data before and after the correction. The average east-west variation with depth of one flow component resembles the average north-south variation with depth of the other component. The east-west variation of the zonal flow together with the north-south variation of the meridional flow can be modeled as a systematic radial velocity. This indicates a solar center-to-limb variation as the underlying cause. The north-south variation of the zonal flow and the east-west variation of the meridional flow require two separate functions. The east-west variation of the meridional flow consists mainly of an annual variation with the B 0 angle, while the north-south trend of the zonal flow consists of a constant non-zero component in addition to an annual variation. This indicates a geometric projection artifact. After compensating for these systematic effects, the meridional and zonal flows derived from HMI data agree well with those derived from GONG data. An offset remains between the zonal flow derived from GONG and HMI data. The equatorward meridional flows at high latitude that appear episodically depending on the B 0 angle are absent from the corrected flows.

  7. Solar Flare Detection With SWIFT and Real-time GONG H-alpha Images

    NASA Astrophysics Data System (ADS)

    Henney, Carl John; MacKenzie, D.; Hill, F.; Mills, B.; Pietrzak, J.

    2011-05-01

    The Air Force Weather Agency (AFWA) has begun the process of upgrading the Solar Observing Optical Network (SOON) with an Improved-SOON (ISOON). During the interim period, AFWA is supporting the addition and operation of a solar H-alpha (Hydrogen-alpha, 656.3 nm) full-disk image network utilizing the light feed from the National Solar Observatory's existing GONG (Global Oscillation Network Group) instruments. The H-alpha instruments at the GONG sites have been in operation collectively since the beginning of 2011, providing one to three H-alpha images per minute. Cross-site comparison and calibration of flare detection has begun using an image analysis tool called SWIFT (SWFL/ISOON Flare-cast Tool). SWIFT is a unique and versatile software package, designed originally for ISOON data, that has been attuned to ingest and display GONG H-alpha images in real-time. The SWIFT software allows a user to detect and analyze optical flares from solar active regions. The SWIFT software is in the process of being beta-tested at AFWA in collaboration with the Space Weather Center of Excellence's SWFL (Space Weather Forecasting Laboratory) to better forecast space weather events. Solar flares are of great interest to the Air Force Research Laboratory's Space Vehicles Directorate because they can trigger energetic particle events or coronal mass ejection events that impact the Earth's magnetosphere creating geomagnetic storms. Such events can result in satellite charging damage, increased satellite drag, power grid disruption, navigation system anomalies, and communication fadeouts. An overview of SWIFT, along with preliminary flare detection comparisons between GONG sites and the SOON flare reports, will be presented.

  8. Stimulation of the Po-shen and Shen-hun scalp-acupuncture bands modifies levels of inhibitory and excitatory amino acids in the immature rat brain.

    PubMed

    Franco-Santana, Lucia Estrella; Torres-Castillo, Sergio; González-Trujano, María Eva; González-Ramírez, Misael

    2013-10-01

    In the present study, the effect of stimulation of the Po-shen and Shen-hun scalp-acupuncture bands on tissue amino acid concentrations in several brain regions in awake and pentobarbital-sedated immature rats was evaluated. Sprague-Dawley rats (aged 15 days) were organized in four groups of at least eight animals: control groups received saline solution 0.9% or sodium pentobarbital at 30mg/kg dosage via intraperitoneal. Experimental groups received saline solution or sodium pentobarbital plus stimulation in Po-shen and Shen-hun scalp-acupuncture bands for one continuous hour during 10 sessions by using scalp-acupuncture. As compared to rats receiving saline solution, scalp-acupuncture produced significant changes in amino acid concentrations, depending on the analyzed region, as follows: in inhibitory amino acids, a GABA increase was observed in amygdala and hippocampus (491 and 184%, respectively), but a decrease in the substantia nigra (80%); glycine showed decrease in all the analyzed regions, except for an increase in brainstem(78%); glutamine presented an increase in hippocampus and cortex (42 and 149%, respectively). In the case of excitatory amino acids, glutamate decreased in all the analyzed regions; whereas aspartate decreased in substantia nigra and brainstem (77.08 and 35%, correspondingly) but increased in hippocampus and cortex (32 and 54%, respectively). The combined treatment of scalp-acupuncture and a GABAergic depressant drug like pentobarbital resulted in almost all changes induced in amino acids for scalp-acupuncture alone being significantly reverted. Stimulation of the Po-shen and Shen-hun scalp-acupuncture bands by using scalp-acupuncture alone might produce depressant activity by changes in amino acids, but the combination with a GABAergic tranquilizer like sodium pentobarbital can interfere with this response. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. [Diversity of endophytic fungi associated with Ferula sinkiangensis K. M. Shen].

    PubMed

    Sun, Li; Zhu, Jun; Li, Xiaojin; Shi, Shubing; Guo, Shunxing

    2014-08-04

    We studied the diversity of endophytic fungi associated with Ferula sinkiangensis K. M. Shen. Endophytic fungi from different years (1-2 years, 3-4 years and > 5 years) and different parts (root, stemand leaf) of Ferula sinkiangensis K. M. Shen were isolated by tissue expand method. Strains were classified by morphology and similarity of internal transcribed spacer (ITS) sequence by Clustal X method. Composition, diversity and preference of endophytic fungal community were analyzed by the isolation rate (IR), isolation frequency (IF), Shannon-Wiener biodiversity index (H'), Margalef Richness index (R). In total 140 endophytic fungi were isolated from F. sinkiangensis K. M. Shen and classified into 18 genera. Among the 140 isolates, Aureobasidium (25.7%), Alternaria (16.4%) and Phyllosticta (15.7%) were the dominant genera. The isolation results show that there were some notable differences between distribution and composition of the endophytic fungi isolated from different years and different parts of Ferula sinkiangensis K. M. Shen. Meanwhile, a certain degree of years and tissue preference were also obvious. The results obtained in this study will be helpful to exploit the endophytic fungal resources of Ferula sinkiangensis K. M. Shen, which can also provide a new way for the realization of the artificial breeding of Ferula sinkiangensis K. M. Shen.

  10. Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum.

    PubMed

    Cárdenas, Andrés; Restrepo, Juan Carlos; Sierra, Fernando; Correa, Gonzalo

    2006-08-01

    Shen-Min is a herbal product sold as a supplement for women to enhance hair growth. It is widely available across Asia, Europe, and the United States and sold without prescription as a hair nutritional supplement. We describe a case of acute liver injury in a 28-year-old white woman who developed symptomatic hepatitis 8 weeks after starting Shen-Min. All other potential causes of acute hepatitis including viral, hypoxic/ischemic, metabolic, and autoimmune etiologies were excluded. The liver injury slowly resolved over 3 weeks after discontinuing the herbal product. Although the mechanism of Shen-Min hepatotoxicity is unknown, we suspect an idiosyncratic reaction because the patient developed a fine maculopapular rash, mild eosinophilia, and did not overdose. Shen-Min is a Chinese herbal product with a mixture of several plants and vitamins including Polygonum multiflorum, a root that has been previously associated with hepatotoxicity. Nonetheless to our knowledge this is the first reported case of herbal-induced hepatotoxicity in a patient taking Shen-Min per se. Clinicians taking care of patients with acute hepatitis of unclear etiology should be aware that the consumption of Shen-Min, a hair supplement widely available in the United States and Western countries might cause acute hepatitis.

  11. LC-MS-Based Quality Assessment of a Traditional Chinese Medicine YANG XIN Formulation.

    PubMed

    Almalki, Ahmad J; Zaher, Ahmed; Simithy, Johayra; Keller, William J; Tripp, Matt; Calderón, Angela I

    2016-08-01

    YANG XIN is a traditional Chinese medicine formulation used for nervous fatigue and consists of a proprietary blend of concentrated extracts from 18 plant ingredients. The 18 constituent plant ingredients, YANG XIN capsules, and formulations 2014-005_1 A and 1B were extracted by consecutive 24-hour macerations with dichloromethane followed by methanol. Metabolite separation was carried out through LC-MS in 40 minutes. Data acquisitions for qualitative and quantitative analyses of the samples were collected under (±) ESI modes and (+) APCI mode using full spectrum scan analysis.A total of 18 analytical markers were identified by LC-MS for YANG XIN formulations based on accurate mass measurements, molecular formula, double bond equivalent, MFG score, and error (ppm) of the measurement. Aditionally, a comparison of the data with previously reported results for the compounds, followed by identity confirmation with standard compounds, was performed. Seventeen analytical markers representing 17 plant ingredients in the different YANG XIN formulations were quantified for the first time. The YANG XIN capsules and the 2014-005_1B formulation were similar to each other and different from the 2014-005_1 A formulation based on the fact that both YANG XIN capsules and the 2014-005_1B formulation contain the same analytical markers. This method provides good linearity (r(2) > 0.9945), intraday precision (R. S. D. < 3.9 %), interday precision (R. S. D. < 5.6 %), accuracy (99.2-101 %), recovery (145.7 %), limit of detection (0.0011-0.0732 µg/mL), and limit of quantitation (0.0038-0.2441 µg/mL).

  12. [Collation between Za Liao of Qian Jin Yi Fang and Xin Xiu Ben Cao].

    PubMed

    Liang, Fei; Jiang, Li-Sheng; Li, Jian; Zhang, Wei; Zhang, Rui-Xian

    2012-10-01

    To analyze specific content of Za Liao of Qian Jin Yi Fang, this essay compares its content with related content of Xin Xiu Ben Cao, finding that Za Liao of Qian Jin Yi Fang is derived from the part of Jin An of Xin Xiu Ben Cao, which complements with herbal chapters from volume II to IV of Qian Jin Yi Fang. The texts in Za Liao can verify and collate part of Jin An, and thereby showing important literature value and great help for further studies on traditional Chinese medicines of Tang dynasty.

  13. MERIDIONAL FLOW IN THE SOLAR CONVECTION ZONE. II. HELIOSEISMIC INVERSIONS OF GONG DATA

    SciTech Connect

    Jackiewicz, J.; Serebryanskiy, A.; Kholikov, S.

    2015-06-01

    Meridional flow is thought to play a very important role in the dynamics of the solar convection zone; however, because of its relatively small amplitude, precisely measuring it poses a significant challenge. Here we present a complete time–distance helioseismic analysis of about 2 years of ground-based Global Oscillation Network Group (GONG) Doppler data to retrieve the meridional circulation profile for modest latitudes in an attempt to corroborate results from other studies. We use an empirical correction to the travel times due to an unknown center-to-limb systematic effect. The helioseismic inversion procedure is first tested and reasonably validated on artificial data from a large-scale numerical simulation followed by a test to broadly recover the solar differential rotation found from global seismology. From GONG data, we measure poleward photospheric flows at all latitudes with properties that are comparable with earlier studies and a shallow equatorward flow about 65 Mm beneath the surface, in agreement with recent findings from Helioseismic and Magnetic Imager (HMI) data. No strong evidence of multiple circulation cells in depth or latitude is found, yet the whole phase space has not yet been explored. Tests of mass flux conservation are then carried out on the inferred GONG and HMI flows and compared to a fiducial numerical baseline from models, and we find that the continuity equation is poorly satisfied. While the two disparate data sets do give similar results for about the outer 15% of the interior radius, the total inverted circulation pattern appears to be unphysical in terms of mass conservation when interpreted over modest time scales. We can likely attribute this to both the influence of realization noise and subtle effects in the data and measurement procedure.

  14. Observing large-scale solar surface flows with GONG: Investigation of a key element in solar activity buildup

    NASA Technical Reports Server (NTRS)

    Beck, John G.; Simon, George W.; Hathaway, David H.

    1996-01-01

    The Global Oscillation Network Group (GONG) solar telescope network has begun regular operations, and will provide continuous Doppler images of large-scale nearly-steady motions at the solar surface, primarily those due to supergranulation. Not only the Sun's well-known magnetic network, but also flux diffusion, dispersal, and concentration at the surface appear to be controlled by supergranulation. Through such magnetoconvective interactions, magnetic stresses develop, leading to solar activity. We show a Doppler movie made from a 45.5 hr time series obtained 1995 May 9-10 using data from three of the six GONG sites (Learmonth, Tenerife, Tucson), to demonstrate the capability of this system.

  15. Sub-surface Meridional Flow Results from MWO, GONG, and MDI during Solar Cycle 23

    NASA Astrophysics Data System (ADS)

    Pinkerton, Stephen; Rhodes, Edward J.; Bogart, Richard S.

    2014-06-01

    Time series of full-disk Dopplergrams were acquired at the 60-Foot Solar tower of the Mount Wilson Observatory every year between 1987 and 2009. Analysis of this archive revealed that the focal plane of the Tower did experience a small amount of systematic rotation, which suggested that the alignment of the optics had changed slightly over the years since its construction in 1907. This has caused some of the initial daily flow maps to possess a so-called “washing machine” effect similar to the pattern that was seen in raw GONG flow maps. We have incorporated a systematic program of ring-diagram analysis in which we have tracked the raw solar images using five differing assumed instrumental rotation rates. We have then gone on to compute synoptic maps of the horizontal flow vectors at several different depths over much of Solar Cycle 23 in order to study how such an instrumental rotation might affect both the zonal and meridional flows as functions of latitude, depth, and time. We compare these results with GONG and MDI flow measurements to empirically determine the regime within which the MWO results are reliable and extend our analysis into Solar Cycle 22.

  16. Solar-Cycle Changes in GONG P-Mode Widths and Amplitudes 1995-1998

    NASA Technical Reports Server (NTRS)

    Komm R. W.; Howe, R.; Hill, F.

    1999-01-01

    We search for a solar cycle variation in mode widths and amplitudes derived from 3-month GONG time series. The variation of mode width and amplitude observed in GONG data are the combined effects of fill factor, temporal variation, and measurement uncertainties. The largest variation is caused by the fill factor resulting in modes with increased width and reduced amplitude when fill is lower. We assume that the solar cycle variation is the only other systematic variation beside the temporal window function effect. We correct all currently available data sets for the fill factor and simultaneously derive the solar cycle variation. We find an increase of about 3% on average in mode width from the previous minimum to Oct. 1998 and a decrease of about 7% and 6% in mode amplitude and mode area (width x amplitude). We find no l dependence of the solar-cycle changes. As a function of frequency, these changes show a maximum between 2.7 and 3.3 mHz with about 47% higher than average values for mode width and about 29% and 36% higher ones for mode amplitude and area. We estimate the significance of these rather small changes by a pre-whitening method and find that the results are significant at or above the 99.9% level with mode area showing the highest level of significance and mode width the lowest. The variation in background amplitude is most likely not significant and is consistent with a zero change.

  17. Effects of Shen'an granules on Wnt signaling pathway in mouse models of diabetic nephropathy.

    PubMed

    Zou, Xin-Rong; Wang, Xiao-Qin; Hu, Ying-Lin; Zhou, Hui-Lan

    2016-12-01

    The effect of Shen'an granules on the Wnt signaling pathway in renal tissues of mouse models of streptozotocin (STZ)-induced diabetic nephropathy was investigated in the present study. A total of 62 BALB/c mice were randomly divided into the normal control (A group), model (B group), losartan (C group), low-dose Shen'an granules (D group), and high-dose Shen'an granules (E group) groups. The mouse model of diabetic nephropathy was established by a single intraperitoneal injection of STZ (150 mg/kg). The animals were treated with drugs for 8 weeks, and blood creatinine, blood urea nitrogen, triglycerides (TG), and total cholesterol (CHOL) were measured prior to and after treatment. PAS staining was performed for observation of glomerular microstructure by light microscope, and western blot analysis was performed to detect Wnt1 protein and β-catenin protein. The results indicated that the quantification of 24-h microalbuminuria, and levels of blood creatinine, urea nitrogen, TG, and CHOL were significantly lower in the high- and low-dose Shen'an granules groups than those in the model group (p<0.05). The expression levels of Wnt1 protein and β-catenin protein in the high- and low-dose Shen'an granules groups were significantly lower than those in the model group (p<0.05). In conclusion, proteinuria, renal dysfunction, and dyslipidemias are closely associated with the abnormal activation of the Wnt signaling pathway in the mouse model of diabetic nephropathy. The mechanism by which Shen'an granules regulate proteinuria, renal function, and blood lipids may be associated with inhibition of the abnormally activated Wnt signaling pathway.

  18. Effects of Shen'an granules on Wnt signaling pathway in mouse models of diabetic nephropathy

    PubMed Central

    Zou, Xin-Rong; Wang, Xiao-Qin; Hu, Ying-Lin; Zhou, Hui-Lan

    2016-01-01

    The effect of Shen'an granules on the Wnt signaling pathway in renal tissues of mouse models of streptozotocin (STZ)-induced diabetic nephropathy was investigated in the present study. A total of 62 BALB/c mice were randomly divided into the normal control (A group), model (B group), losartan (C group), low-dose Shen'an granules (D group), and high-dose Shen'an granules (E group) groups. The mouse model of diabetic nephropathy was established by a single intraperitoneal injection of STZ (150 mg/kg). The animals were treated with drugs for 8 weeks, and blood creatinine, blood urea nitrogen, triglycerides (TG), and total cholesterol (CHOL) were measured prior to and after treatment. PAS staining was performed for observation of glomerular microstructure by light microscope, and western blot analysis was performed to detect Wnt1 protein and β-catenin protein. The results indicated that the quantification of 24-h microalbuminuria, and levels of blood creatinine, urea nitrogen, TG, and CHOL were significantly lower in the high- and low-dose Shen'an granules groups than those in the model group (p<0.05). The expression levels of Wnt1 protein and β-catenin protein in the high- and low-dose Shen'an granules groups were significantly lower than those in the model group (p<0.05). In conclusion, proteinuria, renal dysfunction, and dyslipidemias are closely associated with the abnormal activation of the Wnt signaling pathway in the mouse model of diabetic nephropathy. The mechanism by which Shen'an granules regulate proteinuria, renal function, and blood lipids may be associated with inhibition of the abnormally activated Wnt signaling pathway. PMID:28105085

  19. The Parameters and the Accuracy of Low Spherical Degree Modes from GONG Observations

    NASA Astrophysics Data System (ADS)

    Gavryuseva, E.; Gavryusev, V.

    We have used the longest possible sets of GONG data covering 830 days of almost continuous observations during the solar activity minima. It makes these data are unique and homogeneous, and the best for the search of limit characteristics of the shape of a single mode with any {n, ell, m}. The study of the accuracy of the parameters of the oscillations as a function of the length of the data set has been performed. The statistical determination of the frequency, line-width, amplitude and their error bars for n = 8-26, ell = 0, 1, 2, 3, 4 and m = 0,+/-1, ... ,+/-ell has been carried out, and compared with the results of other experiments.

  20. Detailed Image Comparison using MDI, HMI and GONG Co-Eval Observations

    NASA Astrophysics Data System (ADS)

    Korzennik, Sylvain G.

    2017-08-01

    I present preliminary results from detailed image comparison using MDI, HMI and GONG co-eval observations taken in 2014, when all three instruments were operational. This comparison allows me to estimate both the instrumental image distortion and the instrument PSF, with respect to HMI. Both intensity and velocity images are compared when available. The precise observing perspective of each instrument had to be accounted since it affects the projected image on the instrument detector at the required level of precision (i.e., a fraction of an HMI pixel). In the process, it was discovered that the meta data generated by the respective projects were not accurate enough. While the inclusion of the image distortion and the instrument PSF in the spatial decomposition will improve the determination of high degree modes, it may also benefit other local helioseismic analysis.

  1. [Diversity of ectomycorrhizal fungi associated with Picea asperata in Xin Jiashan Forest of Qinling Mountains].

    PubMed

    Geng, Rong; Geng, Zengchao; Huang, Jian; He, Wenxiang; Hou, Lin; She, Diao; Zhao, Jun; Shang, Jie

    2015-07-04

    To study the diversity of ectomycorrhizal fungi associated with Picea asperata in Xin Jiashan Forest of Qinling Mountains. This method combined the field investigation, morphological and molecular biology to identify ectomycorrhizal fungi. There were 37 different ectomycorrhizal fungi under 14 genera of 10 families on spruce in Xin Jiashan Forest of Qinling Mountains, 34 types belonged to Basidiomycetes, 1 to Ascomycete and 2 to unknown species. Among these identified ectomycorrhizal fungi types, Inocybe sp. was the dominant group; Russula nauseosa was the most dominant species; Hygrophorus sp., Tomentella coerulea, Inocybe sp. 1, Helotiaceae sp. and Lactarius deterrimus were common species; and the rest species were rare species. The large number but relatively rare species of dominant family and the small number but relatively more species of rare family survived in ectomycorrhizal fungal communities of Picea asperata. For the extreme degradation in arid area of western ecological system, identifing some rare family for further development and utilization had very important practical significance.

  2. Undersea safety mining of the large gold deposit in Xinli District of Sanshandao Gold Mine

    NASA Astrophysics Data System (ADS)

    Liu, Zhi-xiang; Dang, Wen-gang; He, Xian-qun

    2012-07-01

    The exploration of undersea resources becomes popular as land resources decrease. Researches were conducted with emphasis on the safety and efficiency of undersea mining of the large gold deposit in Xinli District of Sanshandao Gold Mine. A series of tests for the physical and mechanical characteristics of rock mass were carried out, and the three-dimensional geo-stress distribution was tested in the mining area. Further, a similar experimental simulation platform, which revealed the mechanism of water inrush and ascertained the reasonable thickness of the safety isolate layer, was established for the undersea mining. Meanwhile, the feasibility of cancelling the ore pillars and the safety conditions was checked by numerical simulation. The simulation results show that it is safe to exploit the ore body below the -85 m level (presently, the exploitation level is below -160 m in Xinli District), and the ore pillars can be cancelled below the -560 m level. Furthermore, a novel backfill method was designed to reduce the rock strata disturbance and settlement, and the settlement of roof strata was monitored during the mining process. Engineering practice shows that the settlement of roof strata was small and that no disaster happened. This indicates that the undersea safety mining technology of the large gold deposit is achieved in Xinli District.

  3. [Effects of land use structure on water quality in Xin'anjiang River].

    PubMed

    Cao, Fang-Fang; Li, Xue; Wang, Dong; Zhao, Yue; Wang, Yu-Qiu

    2013-07-01

    Take Xin'anjiang upstream watershed as a case study. Based on data of interpreting TM orthophoto images and water quality monitoring in May 2010, the land use map of Xin'anjiang River, which was categorized to cultivated land, forestland, grassland, water body, building site, was obtained. Using ArcGIS hydrological and spatial analysis function, Xin'anjiang River was divided into eight sub-watersheds, and its watershed land use structure was analyzed. The water quality parameters such as TN, TP, permanganate index, fecal coliform bacteria were monitored from Jan 2010 to Dec 2010. The relations between water quality and land use were analyzed. The results showed that TN and NH4(+) -N had a significant temporal variation: dry season > wet season > normal river flow period, but other parameters did not vary significantly. In the space, Yuliang and Pukou were the most serious pollution sites. Cultivated land, water body, building site had a positive impact on water quality parameters, while there were negative correlation between the forestland and grassland. Annually, cultivated land had the most significantly important effect on TN, NH4(+) -N and permanganate index, and grassland had the most significantly important effect on TP. Cultivated land had the most prominently important impact on water quality parameters in dry season and wet season. What's more, in the normal river flow, cultivated land, grassland and forestland had the most remarkably important influence on TN, TP and fecal coliform bacteria respectively.

  4. [Line scanning analysis of white porcelain from Gong Kiln in early Tang dynasty by energy disperse X-ray fluorescence].

    PubMed

    Ling, Xue; Mao, Zhen-wei; Feng, Min; Hu, Yao-wu; Wang, Chang-sui; Liu, Hong-miao

    2005-07-01

    Gong kiln, for its long porcelain-firing history, was one of three representative white porcelain kilns in northern China. In order to improve the quality and whiteness of white porcelain, a decorating layer or cosmetic earth was laid on the body surface in Gong kiln during early Tang dynasty, which was able to blot out rough surface and weaken the influence of fuscous body upon surface color. In this paper the main chemical composition of the white porcelain's profile was analyzed by using energy disperse X-Ray fluorescence. The result showed that different materials were used as cosmetic earth during early Tang dynasty, in accordance with the phenomenon under optical microscope. In addition, the glaze belongs to calcium glaze in which plant ash was added.

  5. ANATOMY OF A SOLAR FLARE: MEASUREMENTS OF THE 2006 DECEMBER 14 X-CLASS FLARE WITH GONG, HINODE, AND RHESSI

    SciTech Connect

    Matthews, S. A.; Zharkov, S.; Zharkova, V. V.

    2011-10-01

    Some of the most challenging observations to explain in the context of existing flare models are those related to the lower atmosphere and below the solar surface. Such observations, including changes in the photospheric magnetic field and seismic emission, indicate the poorly understood connections between energy release in the corona and its impact in the photosphere and the solar interior. Using data from Hinode, TRACE, RHESSI, and GONG we study the temporal and spatial evolution of the 2006 December 14 X-class flare in the chromosphere, photosphere, and the solar interior. We investigate the connections between the emission at various atmospheric depths, including acoustic signatures obtained by time-distance and holography methods from the GONG data. We report the horizontal displacements observed in the photosphere linked to the timing and locations of the acoustic signatures we believe to be associated with this flare, their vertical and horizontal displacement velocities, and their potential implications for current models of flare dynamics.

  6. Shen-Jing as a Chinese medicine concept might be a counterpart of stem cells in regenerative medicine.

    PubMed

    Ren, Yan-Bo; Huang, Jian-Hua; Cai, Wai-Jiao; Shen, Zi-Yin

    2015-07-04

    As the epitome of the modern regenerative medicine, stem cells were proposed in the basic sense no more than 200 years ago. However, the concept of "stem cells" existed long before the modern medical description. The hypothesis that all things, including our sentient body, were generated from a small origin was shared between Western and Chinese people. The ancient Chinese philosophers considered Jing (also known as essence) as the origin of life. In Chinese medicine (CM), Jing is mainly stored in Kidney (Shen) and the so-called Shen-Jing (Kidney essence). Here, we propose that Shen-Jing is the CM term used to express the meaning of "origin and regeneration". This theoretical discovery has at least two applications. First, the actions underlying causing Shen-Jing deficiency, such as excess sexual intercourse, chronic diseases, and aging, might damage the function of stem cells. Second, a large number of Chinese herbs with Shen-Jing-nourishing efficacy had been proven to affect stem cell proliferation and differentiation. Therefore, if Shen-Jing in CM is equivalent with stem cells in regenerative medicine, higher effective modulators for regulating stem-cell behaviors from Kidney-tonifying herbs would be expected.

  7. Using SDO and GONG as Calibration References for a New Telescope Pointing Algorithm

    NASA Astrophysics Data System (ADS)

    Staiger, J.

    2013-12-01

    Long duration observations are a basic requirement for most types of helioseismic measurements. Pointing stability and the quality of guiding is thus an important issue with respect to the spatio-temporal analysis of any velocity datasets. Existing pointing tools and correlation-tracking devices will help to remove most of the spatial deviations building up during an observation with time. Yet most ground- and space-based high-resolution solar telescopes may be subject to slow image-plane drift that cannot be compensated for by guiding and which may accumulate to displacements of 10″ or more during a 10-hour recording. We have developed a new pointing model for solar telescopes that may overcome these inherent guiding-limitations. We have tested the model at the Vacuum Tower Telescope (VTT), Tenerife. We are using SDO and GONG full-disk imaging as a calibration reference. We describe the algorithms developed and used during the tests. We present our first results. We describe possible future applications as to be implemented at the VTT. So far, improvements over classical limb-guider systems by a factor of 10 or more seem possible.

  8. Exploring a Conceptual Model-Based Approach to Teaching Situated Word Problems: A Rejoinder to Jitendra's Response to Yan Ping Xin and Dake Zhang

    ERIC Educational Resources Information Center

    Xin, Yan Ping; Zhang, Dake

    2011-01-01

    This article presents the authors' response to Asha K. Jitendra's Response to Xin and Zhang ("The Journal of Educational Research," 2009, Vol. 102, No. 6). The claim of "factual errors, including inappropriate quotes, misrepresentation of information, and inadequate scholarship in Xin and Zhang's text" are not justified. In this rejoinder, the…

  9. Exploring a Conceptual Model-Based Approach to Teaching Situated Word Problems: A Rejoinder to Jitendra's Response to Yan Ping Xin and Dake Zhang

    ERIC Educational Resources Information Center

    Xin, Yan Ping; Zhang, Dake

    2011-01-01

    This article presents the authors' response to Asha K. Jitendra's Response to Xin and Zhang ("The Journal of Educational Research," 2009, Vol. 102, No. 6). The claim of "factual errors, including inappropriate quotes, misrepresentation of information, and inadequate scholarship in Xin and Zhang's text" are not justified. In this rejoinder, the…

  10. Tong-xin-luo capsule for patients with coronary heart disease after percutaneous coronary intervention.

    PubMed

    Mao, Chen; Fu, Xiao-Hong; Yuan, Jin-Qiu; Yang, Zu-Yao; Chung, Vincent C H; Qin, Ying; Huang, Yafang; Tam, Wilson Wai San; Kwong, Joey S W; Xie, Wei; Tang, Jin-Ling

    2015-05-21

    Percutaneous coronary intervention (PCI) is a standard treatment for coronary heart disease (CHD). Restenosis, defined as a 50% reduction in luminal diameter at six months after PCI, indicates a need for revascularisation. Restenosis has proven to be a major drawback to PCI. Tong-xin-luo is one of the prophylactic strategies for cardiovascular events in patients after PCI that is widely used in China, but its efficacy and safety have not been systematically evaluated. To systematically assess the efficacy and safety of Tong-xin-luo capsules in preventing cardiovascular events after PCI in patients with CHD. We searched the Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE (OVID), EMBASE (OVID), WanFang, Chinese Biomedical Database, Chinese Medical Current Contents, and China National Knowledge Infrastructure from their inception to June 2014. We also searched other resources, including ongoing trials and research registries. We applied no language restrictions. Randomised controlled trials of participants with CHD after PCI were included. Participants in the intervention group received Tong-xin-luo capsules for at least three months. Two review authors independently extracted data and assessed the risk of bias. Any disagreements were resolved by discussion with a third review author. The primary outcomes included occurrence of angiographic restenosis and adverse events; the secondary outcomes included myocardial infarction, heart failure, angina, all cause mortality, mortality due to any cardiovascular event, use of revascularisation, patient acceptability, quality of life and cost-effectiveness. Dichotomous data were measured with risk ratios (RRs) with 95% confidence intervals (CIs). Sixteen studies involving 1063 participants were identified. The risk of bias for fifteen studies was high and along with imprecision and possible publication bias, this lowered our confidence in the results. There was low quality evidence that Tong

  11. [Experience of treatment and understanding of impediment disease in Shen nong ben cao jing (Shen-ntonz's Classic of Materia Medica)].

    PubMed

    Ding, Hongchang; Wang, Zhenrui

    2015-01-01

    As a book with significant historical materials for the research of impediment disease not to be ignored, Shen nong ben cao jing (Shennong's Classic of Materia Medica) contains, among its 365 kinds of materia medica, 75 kinds of medicines related to impediment disease. Among the latter ones, 51 are related to "damp impediment", "cold-damp impediment", "wind-cold-damp impediment", "wind impediment", "wind-damp impediment", and "cold impediment"; 16 are related to "laryngeal impediment", "general impediment", and "blood impediment"; 8 are related to "muscular impediment", "stomach impediment", "hernia-conglomeration impediment", "internal consumptive-thirst impediment", "wilting impediment", and "hemiplegic impediment". To systematically analyze the properties, tastes, and effects of these medicines and its related knowledge, and then further explore the overall recognition and their treating experience of the physicians at that period would not only enrich the historical research on impediment disease, but also offer much help and reference to the understanding and treatment of impediment for contemporary clinicians.

  12. [Study on processing adjuvant medicines in Lei Gong's treatise on preparation and broiling of materia medica (Leigong Paozhi Lun)].

    PubMed

    Zhang, Wei; Zhang, Ruixian

    2010-09-01

    There were 268 kinds of medicines recorded in the book of Lei Gong's Treatise on preparation and broiling of materia medica (Leigong Paozhi Lun). Among these medicines, 178 medicines were prepared with adjuvant medicines, including general and special compatible adjuvant medicines. These adjuvant medicines used in this book can be explained by the theory of "seven-relation compatibility". The author tried to explain the usage and their compatibility of these adjuvant medicines and put forward that attention should be paid to the changes in functions of medicines and the influences of society should be paid attention.

  13. [Investigation of JinKui ShenQi pills by ultraviolet spectra and tandem mass spectrometry].

    PubMed

    Li, Wen-lan; Sun, Zhi; Cheng, Bin; Ji, Yu-bin; Bai, Jing

    2008-08-01

    On the base of establishing the fingerprint of JinKui ShenQi pills, the ultraviolet spectra-mass spectrometry/mass spectrometry, method was used to identify the fingerprint. Seperation was performed on the Symmetry Shield RP18 (5 microm, 4. 6 mm X 15 mm) analytical column with mobile phase consisting of 1% acetic acid and acetonitrile with gradient elute at the flow rate of 1.0 mL x min(-1), and the ultraviolet detection wavelength was set at 248 nm. Using the above-mentioned chromatographic condition, the fingerprint of different samples was established and the same fingerprint was defined. The fingerprints of different samples were compared with similarity evaluation software published by Pharmacopeia committee codex (2004A). The mass spectrograph with API-ESI ionization source was used, setting the flow rate at 0.5 mL x min(-1) after splitting stream. The pressure of atomization room was 50 Psi, the flow rate of dry gas was 9.0 L x min(-1), the capillary voltage was 4 kV, and the transmission voltage was 70 V. The negative scanner mode was chosen, scan scope was 100-2000, using ion trap to analyze quasimolecular ion peak and the selected fragment ion, and TIC chromatography and second order mass chromatogram were recorded. The major constituents among in JinKui ShenQi pills from different origins were separated well by HPLC. Although there was difference among different origins, they showed nineteen identical characteristic absorption bands. Three fingerprints chemical compositions such as loganin, cinnamal and paeonol were identified based on the retention time and ultraviolet spectra of standard preparation. According to their ultraviolet spectra, molecular weight and fragmentation information, ten peaks in the fingerprint were identified by ultraviolet spectroscopy-mass, spectrometry/massg spectrometry. They are 1,2,3-tri-O-galloyl-glucose, loganin, paeoniflorin, 1,2,3,6-tetro-O-galloyl-glucose, soya-cerebroside, cornuside, and PGG, benzoyl

  14. Probing the solar cycle: a comparative and complementary analysis of GONG BiSON and VIRGO/LOI eigenfrequency shifts

    NASA Astrophysics Data System (ADS)

    Chaplin, W. J.; Elsworth, Y.; Isaak, G. R.; New, R.; Appourchaux, T.

    2001-01-01

    We use high-quality helioseismic data collected by GONG (over 4 <= l <= 140), BiSON (0 <= l <= 2) and VIRGO/LOI (0 <= l <= 8) to study the phenomenological nature of the cycle-induced (centroid) eigenfrequency variations. We have analyzed the frequency dependence of the shifts by fitting a power-law of the form δνnl ~ (νnl)α/Enl to the data (where the Enl are the mode inertias, and α is the power-law index to be extracted). Previous studies have suggested that a relation with α = 0 provides an adequate description of the shifts up to ν ≍ 3500 μHz. However, here we show that while nevertheless describing the shifts well up to ~2500 μHz, the linear scaling breaks down conspicuously at higher frequencies. Above this threshold, the shifts follow a power-law dependence with α ~ 2. We also ahow that GONG shifts, averaged over different ranges in l together with the BiSON and LOI data averaged over their full quoted ranges, all scale at fixed frequency with the normalized mode inertia ratio Qnl (Christensen-Dalsgaard & Berthomieu 1991). This is to be expected if the solar-cycle perturbation affecting the modes is confined in the surface layers; the excellent agreement also reflects favourably on the external consistency of the different observations.

  15. [Progress of studies on tumor stem cell and anti-cancer treatment by nourishing Shen essence and qi].

    PubMed

    Zheng, Zhan; Xu, Zhen-ye

    2007-01-01

    The tumor stem cells (TSC) existing in the tumor plays a crucial role in carcinogenesis though very few in number. It is a special kind of stem cells with highly proliferative and self-regenerative cap ability to maintain its number stable and generate tumor. Therefore, the radical treatment of tumor should focus on TSC. TSC are derived from adult stem cells. According to TCM theory, normal stem cells belong to the category of Shen essence and qi, and patients suffering from malignant tumor always manifest as the syndrome of essence and qi deficiency, so nourishing Shen essence and qi should be of great importance for treatment of tumor.

  16. [Textual research on personnels revising Xin xiu ben cao (newly Revised Herbology)].

    PubMed

    Wang, J; Zhang, R; Yin, H

    2000-10-01

    The problem is investigated by studying annals of Tang - Song period and relevant materials. It is claimed that at the time when Sujing's report was submitted in the second year of Xianqing reign, the officials surveilling and revising the text include in order: ZHANG SUN Wuji, LI Ji, YU Zhining etc, together with SU Jing, the total number being 23. Changes appeared in this number at the time when the work was finished in the fourth year of Xianqing reign. Though, by then, the number involved was still 23, yet the order of LI Ji and ZHANG SUN Wuji was reversed, and Xin Mao jiang took the place of YU Zhining. In addition, the birth time of SU Jing was investigated to be 595 - 600.

  17. [Professor Chen Quan-xin's experiences on treatment of facial paralysis].

    PubMed

    Wu, Hao

    2011-05-01

    The clinical experiences of Professor Chen Quan-xin on treatment of facial paralysis are introduced. Based on the theory of Chinese medicine and instructed by differentiation of syndromes, Professor Chen attached great importance on analysis of etiology and pathology in modern medicine, and emphasized on treatment of facial paralysis according to different classifications and stages in combination of differentiation of syndromes and differentiation of diseases. His selection of point is refined and accurate. Conduct of qi through needling manipulations and reinforcing and reducing methods in various degrees are promoted by him as well. And it is held that obvious enhancement of the therapeutic effect can be achieved since other treatments are combined according to different types and stages of the disease.

  18. A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the Xin repeats is required for maintenance of stereocilia morphology and hearing function.

    PubMed

    Francis, Shimon P; Krey, Jocelyn F; Krystofiak, Evan S; Cui, Runjia; Nanda, Sonali; Xu, Wenhao; Kachar, Bechara; Barr-Gillespie, Peter G; Shin, Jung-Bum

    2015-02-04

    Approximately one-third of known deafness genes encode proteins located in the hair bundle, the sensory hair cell's mechanoreceptive organelle. In previous studies, we used mass spectrometry to characterize the hair bundle's proteome, resulting in the discovery of novel bundle proteins. One such protein is Xin-actin binding repeat containing 2 (XIRP2), an actin-cross-linking protein previously reported to be specifically expressed in striated muscle. Because mutations in other actin-cross-linkers result in hearing loss, we investigated the role of XIRP2 in hearing function. In the inner ear, XIRP2 is specifically expressed in hair cells, colocalizing with actin-rich structures in bundles, the underlying cuticular plate, and the circumferential actin belt. Analysis using peptide mass spectrometry revealed that the bundle harbors a previously uncharacterized XIRP2 splice variant, suggesting XIRP2's role in the hair cell differs significantly from that reported in myocytes. To determine the role of XIRP2 in hearing, we applied clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-mediated genome-editing technology to induce targeted mutations into the mouse Xirp2 gene, resulting in the elimination of XIRP2 protein expression in the inner ear. Functional analysis of hearing in the resulting Xirp2-null mice revealed high-frequency hearing loss, and ultrastructural scanning electron microscopy analyses of hair cells demonstrated stereocilia degeneration in these mice. We thus conclude that XIRP2 is required for long-term maintenance of hair cell stereocilia, and that its dysfunction causes hearing loss in the mouse.

  19. A Short Splice Form of Xin-Actin Binding Repeat Containing 2 (XIRP2) Lacking the Xin Repeats Is Required for Maintenance of Stereocilia Morphology and Hearing Function

    PubMed Central

    Francis, Shimon P.; Krey, Jocelyn F.; Krystofiak, Evan S.; Cui, Runjia; Nanda, Sonali; Xu, Wenhao; Kachar, Bechara; Barr-Gillespie, Peter G.

    2015-01-01

    Approximately one-third of known deafness genes encode proteins located in the hair bundle, the sensory hair cell's mechanoreceptive organelle. In previous studies, we used mass spectrometry to characterize the hair bundle's proteome, resulting in the discovery of novel bundle proteins. One such protein is Xin-actin binding repeat containing 2 (XIRP2), an actin-cross-linking protein previously reported to be specifically expressed in striated muscle. Because mutations in other actin-cross-linkers result in hearing loss, we investigated the role of XIRP2 in hearing function. In the inner ear, XIRP2 is specifically expressed in hair cells, colocalizing with actin-rich structures in bundles, the underlying cuticular plate, and the circumferential actin belt. Analysis using peptide mass spectrometry revealed that the bundle harbors a previously uncharacterized XIRP2 splice variant, suggesting XIRP2's role in the hair cell differs significantly from that reported in myocytes. To determine the role of XIRP2 in hearing, we applied clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-mediated genome-editing technology to induce targeted mutations into the mouse Xirp2 gene, resulting in the elimination of XIRP2 protein expression in the inner ear. Functional analysis of hearing in the resulting Xirp2-null mice revealed high-frequency hearing loss, and ultrastructural scanning electron microscopy analyses of hair cells demonstrated stereocilia degeneration in these mice. We thus conclude that XIRP2 is required for long-term maintenance of hair cell stereocilia, and that its dysfunction causes hearing loss in the mouse. PMID:25653358

  20. The effects of dan-shen root on cardiomyogenic differentiation of human placenta-derived mesenchymal stem cells

    SciTech Connect

    Li, Kun; Li, Shi-zheng; Zhang, Yun-li; Wang, Xue-zhe

    2011-11-11

    Highlights: Black-Right-Pointing-Pointer Conditional medium and dan-shen root were used for cardiomyogenic differentiation. Black-Right-Pointing-Pointer They all could induce hPDMSCs to differentiate into cardiomyocytes. Black-Right-Pointing-Pointer The induction effect of the latter was slightly higher compared to that of the former. Black-Right-Pointing-Pointer Dan-shen root could be a good inducer for cardiomyogenic differentiation. -- Abstract: The aim of this study was to search for a good inducer agent using for cardiomyogenic differentiation of stem cells. Human placenta-derived mesenchymal stem cells (hPDMSCs) were isolated and incubated in enriched medium. Fourth passaged cells were treated with 10 mg/L dan-shen root for 20 days. Morphologic characteristics were analyzed by confocal and electron microscopy. Expression of {alpha}-sarcomeric actin was analyzed by immunohistochemistry. Expression of cardiac troponin-I (TnI) was analyzed by immunohistofluorescence. Atrial natriuretic factor (ANF) and beta-myocin heavy chain ({beta}-MHC) were detected by reverse transcriptase polymerase chain reaction (RT-PCR). hPDMSCs treated with dan-shen root gradually formed a stick-like morphology and connected with adjoining cells. On the 20th day, most of the induced cells stained positive with {alpha}-sarcomeric actin and TnI antibody. ANF and {beta}-MHC were also detected in the induced cells. Approximately 80% of the cells were successfully transdifferentiated into cardiomyocytes. In conclusion, dan-shen root is a good inducer agent used for cardiomyogenic differentiation of hPDMSCs.

  1. VizieR Online Data Catalog: SDSS-RM project: peak velocities of QSOs (Shen+, 2016)

    NASA Astrophysics Data System (ADS)

    Shen, Y.; Brandt, W. N.; Richards, G. T.; Denney, K. D.; Greene, J. E.; Grier, C. J.; Ho, L. C.; Peterson, B. M.; Petitjean, P.; Schneider, D. P.; Tao, C.; Trump, J. R.

    2017-01-01

    The SDSS-RM quasar sample includes 849 broad-line quasars at 0.1Shen+ 2016, in preparation). The spectroscopic data used in this work are from the 32 epochs taken in 2014 as part of the SDSS-RM project within the SDSS-III (Eisenstein+ 2011AJ....142...72E) Baryon Oscillation Spectroscopic Survey (BOSS, Dawson+ 2013AJ....145...10D), using the BOSS spectrograph on the 2.5m SDSS telescope. The wavelength coverage of BOSS spectroscopy is ~3650-10400Å, with a spectral resolution of R~2000. (1 data file).

  2. Seasonal-Spatial Distribution and Long-Term Variation of Transparency in Xin'anjiang Reservoir: Implications for Reservoir Management.

    PubMed

    Wu, Zhixu; Zhang, Yunlin; Zhou, Yongqiang; Liu, Mingliang; Shi, Kun; Yu, Zuoming

    2015-08-12

    Water transparency is a useful indicator of water quality or productivity and is widely used to detect long-term changes in the water quality and eutrophication of lake ecosystems. Based on short-term spatial observations in the spring, summer, and winter and on long-term site-specific observation from 1988 to 2013, the spatial, seasonal, long-term variations, and the factors affecting transparency are presented for Xin'anjiang Reservoir (China). Spatially, transparency was high in the open water but low in the bays and the inflowing river mouths, reflecting the effect of river runoff. The seasonal effects were distinct, with lower values in the summer than in the winter, most likely due to river runoff and phytoplankton biomass increases. The transparency decreased significantly with a linear slope of 0.079 m/year, indicating a 2.05 m decrease and a marked decrease in water quality. A marked increase occurred in chlorophyll a (Chla) concentration, and a significant correlation was found between the transparency and Chla concentration, indicating that phytoplankton biomass can partially explain the long-term trend of transparency in Xin'anjiang Reservoir. The river input and phytoplankton biomass increase were associated with soil erosion and nutrient loss in the catchment. Our study will support future management of water quality in Xin'anjiang Reservoir.

  3. [Essence of professor SHI Xin-de's experience in application of persicae ramulus-associated prescriptions].

    PubMed

    Du, Xin-Liang

    2014-07-01

    Persicae Ramulus decoction, as the first prescription in Treatise on febrile Diseases, has been recommended by physicians of successive generations. It is also the general prescription for harmonizing yingfen and weifen, yin and yang, qi and blood. Although it only consists of five herbal medicines, it has a wider range of application and more categorized formulas than other prescriptions. Though Persicae Ramulus decoction was originally formulated to treat taiyang apoplexy, it has functions beyond the treatment of exopathic diseases. This formula is also effective in treating internal diseases, surgical diseases, gynecologic diseases, paediatric diseases, etc. KE Yun-bo praised it as the No. 1 formula among ZHANG Zhong-jin's formulas as well as the general prescription for harmonizing Yin and Yang, yingfen and weifen, resolving fleshy exterior and inducing perspiration. Professor SHI Xin-de has been expert at treating intractable diseases by using Persicae Ramulus-associated prescriptions, such as Xiaojianzhong decoction and Baohe pill for children's chronic eczema, Persicae Ramulus and Puerariae Lobatae Radix decoction and Yupingfeng powder for chronic nephritis, and Persicae Ramulus and Longgu Muli decoction for insomnia. Instead of being restricted to Chinese or Western disease names, he prescribed appropriate formulas according to syndromes, thereby achieving a good efficacy.

  4. Manufacturing in the Eye of the Storm:Shen Hong and the Nine Great Installations Project During China's Cultural Revolution.

    PubMed

    Sun, Lie; Hu, Danian

    2017-09-01

    The construction of nine high-end technical installations (hereafter Project NGI, for Nine Great Installations or ) in the 1960s and 1970s was an indispensable part of the development of China's defense and heavy industries. The project put more than 1400 machines into operation or trial operation during the Culture Revolution (1966-1976), and they served essential technical functions in sectors such as aviation, aerospace, machinery, metallurgy, and electronics, and directly advancing the development of these fields. It took more than a decade for Project NGI to go from planning to completion-a surprisingly uninterrupted and steady development while China fell into unprecedented turmoil. One important reason for Project NGI's success was the vital leadership of Shen Hong (, 1906-1998), the technical director of the project and a high-ranking official. Supported by state leaders such as Zhou Enlai and Nie Rongzhen, Shen and his colleagues adopted a suitable roadmap for technological development, coordinated the best-performing manufacturing forces in the country, and successfully manufactured the NGI machines. Project NGI is significant for the history of Chinese science, technology, and medicine during the Cultural Revolution not because it was technologically original, but because it represents an extraordinary case, in which the project's technological development seemed to be largely exempted from the interference of the turbulent Cultural Revolution. The project's national defense orientation, its pragmatism, and the contemporary dogma of self-reliance (), in addition to Shen Hong's political maneuvering, all contributed to the creation of a relatively calm and favorable environment around Project NGI. Despite the widespread turmoil in the country, Shen managed to assemble a stable and continuously productive team, which executed experiments, absorbed previously introduced Soviet technologies, stayed informed about advanced European and American technologies

  5. [Learning and Memory Capacity and NMDA Receptor Expression in Shen Deficiency Constitution Rats].

    PubMed

    Sun, Yu-ru; Sun, Yao-guang; Zhang, Qi; Wang, Xiao-di; Wang, Xing; Sun, Li-jun

    2016-05-01

    To explore material bases and neurobiological mechanisms of "Shen storing will" by observing learning and memory capacities and N-methyl-D-aspartic acid (NMDA) receptor expressions in Shen deficiency constitution (SDC) rats. Totally 40 SD rats were randomly divided into the model group, the Zuogui Pill (ZP) group, the Yougui Pill (YP) group, the blank control group (consisting of normal pregnant rats), 10 in each group. SDC young rat model (inherent deficiency and postnatal malnutrition) was prepared by the classic way of "cat scaring rat". Medication started when they were scared by cat. Rats in the ZP group and the YP group were administered by gastrogavage with ZP suspension 0.1875 g/mL and YP suspension 0.0938 g/mL respectively. Equal volume of normal saline was administered to rats in the blank control group and the model group by gastrogavage. All medication was given once per day, 5 days in a week for 2 consecutive months. Learning and memory capacities were detected by Morris water maze test. Expressions of NMDA receptor subunits NR2A and NR2B in hippocamus were detected by immunohistochemical method. Compared with the blank control group, the latency period, total distance in Morris water maze test were longer in the model group (P < 0.05). All the aforesaid indices all decreased in the ZP group and the YP group, with statistical difference when compared with the model group (P < 0.05). The protein expressions of NR2A and NR2B in hippocamus were lower in the model group than in the blank control group (P < 0.05). But when compared with the model group, they were obviously higher in the ZP group and the YP group (P < 0.05). SDC rats had degenerated learning and memory capacities and lowered NMDA receptor expressions. ZP and YP could up-regulate learning and memory capacities and NMDA receptor expressions, thereby improving deterioration of brain functions in SDC rats.

  6. Protective Effect of Shen-Fu Injection on Neuronal Mitochondrial Function in a Porcine Model of Prolonged Cardiac Arrest

    PubMed Central

    Gu, Wei; Hou, XiaoMin; Zhou, Haijiang; Li, ChunSheng

    2014-01-01

    Background. Shen-Fu injection (SFI) following cardiac arrest exhibits neurological effects, but its effect on neurological dysfunction is unclear. This study sought to investigate the protective effect of SFI on nerve cells in a porcine model of cardiac arrest. Methods. After eight minutes of untreated ventricular fibrillation (VF) and 2 minutes of basic life support, 24 pigs were randomized and divided into three cardiopulmonary resuscitation groups, which received central venous injection of either Shen-Fu (SFI group; 1.0 ml/kg), epinephrine (EP group; 0.02 mg/kg), or saline (SA group). Surviving pigs were sacrificed at 24 h after ROSC and brains were removed for analysis for morphologic changes of mitochondria by electron microscopy, for mitochondrial transmembrane potential (MTP) by flow cytometry, and for opening of the mitochondrial permeability transition pore (MPTP) by mitochondrial light scattering. Results. Compared with the EP and SA groups, SFI treatment reduced opening of MPTP, showing higher MMP. In addition, animals treated with SFI showed slight cerebral ultrastructure damage under the electron microscopy. Conclusion. Shen-Fu injection alleviated brain injury, improved neurological ultrastructure, stabilized membrane potential, and inhibited opening of MPTP. Therefore, SFI could significantly attenuate postresuscitation cerebral ischemia and reperfusion injury by modulating mitochondrial dysfunction of nerve cells. PMID:25505924

  7. Improving the Xin'anjiang hydrological model based on mass-energy balance

    NASA Astrophysics Data System (ADS)

    Fang, Yuan-Hao; Zhang, Xingnan; Corbari, Chiara; Mancini, Marco; Niu, Guo-Yue; Zeng, Wenzhi

    2017-07-01

    Conceptual hydrological models are preferable for real-time flood forecasting, among which the Xin'anjiang (XAJ) model has been widely applied in humid and semi-humid regions of China. Although the relatively simple mass balance scheme ensures a good performance of runoff simulation during flood events, the model still has some defects. Previous studies have confirmed the importance of evapotranspiration (ET) and soil moisture content (SMC) in runoff simulation. In order to add more constraints to the original XAJ model, an energy balance scheme suitable for the XAJ model was developed and coupled with the original mass balance scheme of the XAJ model. The detailed parameterizations of the improved model, XAJ-EB, are presented in the first part of this paper. XAJ-EB employs various meteorological forcing and remote sensing data as input, simulating ET and runoff yield using a more physically based mass-energy balance scheme. In particular, the energy balance is solved by determining the representative equilibrium temperature (RET), which is comparable to land surface temperature (LST). The XAJ-EB was evaluated in the Lushui catchment situated in the middle reach of the Yangtze River basin for the period between 2004 and 2007. Validation using ground-measured runoff data proves that the XAJ-EB is capable of reproducing runoff comparable to the original XAJ model. Additionally, RET simulated by XAJ-EB agreed well with moderate resolution imaging spectroradiometer (MODIS)-retrieved LST, which further confirms that the model is able to simulate the mass-energy balance since LST reflects the interactions among various processes. The validation results prove that the XAJ-EB model has superior performance compared with the XAJ model and also extends its applicability.

  8. A Rutile Chevron Modulation in Delafossite-Like Ga3-xIn3TixO9+x/2.

    PubMed

    Rickert, Karl; Boullay, Philippe; Malo, Sylvie; Caignaert, Vincent; Poeppelmeier, Kenneth R

    2016-05-02

    The structure solution of the modulated, delafossite-related, orthorhombic Ga3-xIn3TixO9+x/2 for x = 1.5 is reported here in conjunction with a model describing the modulation as a function of x for the entire system. Previously reported structures in the related A3-xIn3TixO9+x/2 (A = Al, Cr, or Fe) systems use X-ray diffraction to determine that the anion lattice is the source of modulation. Neutron diffraction, with its enhanced sensitivity to light atoms, offers a route to solving the modulation and is used here, in combination with precession electron diffraction tomography (PEDT), to solve the structure of Ga1.5In3Ti1.5O9.75. We construct a model that describes the anion modulation through the formation of rutile chevrons as a function of x. This model accommodates the orthorhombic phase (1.5 ≤ x ≤ 2.1) in the Ga3-xIn3TixO9+x/2 system, which transitions to a biphasic mixture (2.2 ≤ x ≤ 2.3) with a monoclinic, delafossite-related phase (2.4 ≤ x ≤ 2.5). The optical band gaps of this system are determined, and are stable at ∼3.4 eV before a ∼0.4 eV decrease between x = 1.9 and 2.0. After this decrease, stability resumes at ∼3.0 eV. Resistance to oxidation and reduction is also presented.

  9. Modal approach for nonlinear vibrations of damped impacted plates: Application to sound synthesis of gongs and cymbals

    NASA Astrophysics Data System (ADS)

    Ducceschi, M.; Touzé, C.

    2015-05-01

    This paper presents a modal, time-domain scheme for the nonlinear vibrations of perfect and imperfect plates. The scheme can take into account a large number of degrees-of-freedom and is energy-conserving. The targeted application is the sound synthesis of cymbals and gong-like musical instruments, which are known for displaying a strongly nonlinear vibrating behaviour. This behaviour is typical of a wave turbulence regime, in which the wide-band spectrum of excited modes is observable in the form of an energy cascade. The modal method is selected for its versatility in handling complex damping laws that can be implemented easily by selecting appropriate damping values in each one of the modal equations. In the first part of the paper, the modal method is explained in its generality, and it will be seen that the method is valid for plates with arbitrary geometry and boundary conditions as long as the eigenmodes are known. Secondly, a time-integration, energy-conserving scheme for perfect and imperfect plates is presented, and implementation comments are given in order to treat efficiently the high-dimensionality of the resulting dynamical system. The scheme is run with appropriate parameters in order to produce sound samples. A simple impact law is considered for the excitation, whereas the flexibility of the method is highlighted by showing simulations for free-edge circular plates and simply-supported rectangular plates, together with various damping laws.

  10. Coaxial CVD diamond detector for neutron diagnostics at ShenGuang III laser facility

    NASA Astrophysics Data System (ADS)

    Yu, Bo; Liu, Shenye; Chen, Zhongjing; Huang, Tianxuan; Jiang, Wei; Chen, Bolun; Pu, Yudong; Yan, Ji; Zhang, Xing; Song, Zifeng; Tang, Qi; Hou, Lifei; Ding, Yongkun; Zheng, Jian

    2017-06-01

    A coaxial, high performance diamond detector has been developed for neutron diagnostics of inertial confinement fusion at ShenGuangIII laser facility. A Φ10 mm × 1 mm "optical grade" chemical-vapor deposition diamond wafer is assembled in coaxial-designing housing, and the signal is linked to a SubMiniature A connector by the cathode cone. The coaxial diamond detector performs excellently for neutron measurement with the full width at half maximum of response time to be 444 ps for a 50 Ω measurement system. The average sensitivity is 0.677 μV ns/n for 14 MeV (DT fusion) neutrons at an electric field of 1000 V/mm, and the linear dynamic range is beyond three orders of magnitude. The ion temperature results fluctuate widely from the neutron time-of-flight scintillator detector results because of the short flight length. These characteristics of small size, large linear dynamic range, and insensitive to x-ray make the diamond detector suitable to measure the neutron yield, ion temperature, and neutron emission time.

  11. Coaxial CVD diamond detector for neutron diagnostics at ShenGuang III laser facility.

    PubMed

    Yu, Bo; Liu, Shenye; Chen, Zhongjing; Huang, Tianxuan; Jiang, Wei; Chen, Bolun; Pu, Yudong; Yan, Ji; Zhang, Xing; Song, Zifeng; Tang, Qi; Hou, Lifei; Ding, Yongkun; Zheng, Jian

    2017-06-01

    A coaxial, high performance diamond detector has been developed for neutron diagnostics of inertial confinement fusion at ShenGuangIII laser facility. A Φ10 mm × 1 mm "optical grade" chemical-vapor deposition diamond wafer is assembled in coaxial-designing housing, and the signal is linked to a SubMiniature A connector by the cathode cone. The coaxial diamond detector performs excellently for neutron measurement with the full width at half maximum of response time to be 444 ps for a 50 Ω measurement system. The average sensitivity is 0.677 μV ns/n for 14 MeV (DT fusion) neutrons at an electric field of 1000 V/mm, and the linear dynamic range is beyond three orders of magnitude. The ion temperature results fluctuate widely from the neutron time-of-flight scintillator detector results because of the short flight length. These characteristics of small size, large linear dynamic range, and insensitive to x-ray make the diamond detector suitable to measure the neutron yield, ion temperature, and neutron emission time.

  12. Ramp-wave compression experiment with direct laser illumination on Shen Guang III prototype Laser facility

    NASA Astrophysics Data System (ADS)

    Wang, Feng; Xu, Tao; Optical Team Collaboration

    2016-10-01

    Ramp-wave compression (RWC) experiment to balance the high compression pressure generation in aluminum and x-ray blanking effect in transparent window was demonstrated on Shen Guang-III prototype laser facility. A new target concept was proposed to develop a laser-driven shocks-RWC technique for studying material behavior under dynamic, high pressure conditions. As the ``little shocks'' in our experiment cannot be avoided, the effort to diminish the shock under a special level has been demonstrated with Al/Au/Al/LiF target. The highest pressure is about 500GPa after using the multilayer target design Al/Au/Al/LiF and about 1013W/cm2 laser pulse incident on the planer Al target, instantaneously affecting ablation layer located 500 μm away. As the x-ray generated by Al layer had been prevented by the Au layer, the width abrupt onset of strong absorption of an optical probe beam (λ = 532 nm) in LiF window may be the limitation for this kind if RWC experiment during the experiment time scale for 30 μm thick step. With the design laser shape and target structure of Al/Au/Al/LiF, 500GPa may be the highest pressure after balance the preheat effect and ablation efficiency for laser direct-drive experiment.

  13. Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis

    PubMed Central

    Perera, Pathirage Kamal; Li, Yunman; Peng, Cheng; Fang, Weirong; Han, Caifeng

    2010-01-01

    Objective: To investigate the immunomodulating mechanisms of a Chinese herbal medicine Yi Shen Juan Bi (YJB) in treatment of adjuvant arthritis (AA) in rats. Materials and Methods: Levels of serum tumor necrosis factor alpha (TNF-α) and interleukin-1β (IL-1β) were measured by the Enzyme-Linked Immunosorbent Assay (ELISA). Expression of TNF-α mRNA and IL-1β mRNA in synovial cells was measured with the semi-quantitative technique of reverse transcription-polymerase chain reaction (RT-PCR), while caspase-3 was examined by western blot analysis. Results: The administration of YJB significantly decreased the production of serum TNF-α and IL-1β. It also decreased significantly the TNF-α mRNA, IL-1β mRNA, and caspase-3 expression in synoviocytes. Conclusions: YJB produces the immunomodulatory effects by downregulating the over-activated cytokines, while it activates caspase-3, which is the key executioner of apoptosis in the immune system. This may be the one of the underlying mechanisms that explains how YJB treats the rheumatoid arthritis. PMID:20711367

  14. Exploring a Conceptual Model-Based Approach to Teaching Situated Word Problems: A Response to Yan Ping Xin and Dake Zhang

    ERIC Educational Resources Information Center

    Jitendra, Asha K.

    2011-01-01

    This article presents the author's response to Yan Ping Xin and Dake Zhang's recent critical evaluation of her and colleagues' work in "Exploring a Conceptual Model-Based Approach to Teaching Situated Word Problems," published in "The Journal of Educational Research" in 2009 (Vol. 102, No. 6). Most critiques of prior research are written in a fair…

  15. Characterization of multiple constituents in Kai-Xin-San prescription and rat plasma after oral administration by liquid chromatography with quadrupole time-of-flight tandem mass spectrometry.

    PubMed

    Zhang, Xiaowen; Li, Qing; Lv, Chunxiao; Xu, Huarong; Liu, Xujia; Sui, Zhenyu; Bi, Kaishun

    2015-06-01

    A sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry method was established to separate and identify the chemical constituents of Kai-Xin-San prescription, a classic traditional Chinese medicine formula that plays an important role in the treatment of Alzheimer's disease. The detection was performed on an Agilent 6520 Accurate-Mass quadrupole time-of-flight mass spectrometer equipped with an electrospray ionization source in negative modes. With the optimized conditions, a total of 54 compounds were identified or tentatively characterized. Out of the 54 compounds, six compounds were identified by comparing the retention time and mass spectrometry data with reference standards, the rest were characterized by analyzing mass spectrometry data and retrieving the literature data. Results indicated ginsenosides, polygala saponins, terpenoids, and oligosaccharide esters were the major effective constituents in Kai-Xin-San prescription. There were 26 prototype ingredients that were assigned for identification in rat plasma. It is also concluded that the developed ultra high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry method with high sensitivity and resolution is suitable for identifying and characterizing the chemical constituents of Kai-Xin-San prescription, and the analysis provides a helpful chemical basis for further research on Kai-Xin-San prescription and the clinical diagnostics of Alzheimer's disease.

  16. Tectonic controls for transverse drainage and timing of the Xin-Ding paleolake breach in the upper reach of the Hutuo River, north China

    NASA Astrophysics Data System (ADS)

    Ren, Junjie; Zhang, Shimin; Meigs, Andrew J.; Yeats, Robert S.; Ding, Rui; Shen, Xiaoming

    2014-02-01

    The upper reach of the Hutuo River flows along the Xin-Ding basin and cuts a transverse drainage through the Xizhou Mountain and the Taihang Range into the North China Plain. Previous studies showed that the Xin-Ding basin was occupied by a lake during the early-middle Pleistocene. However, the timing of the paleolake breach and the mechanism for the creation of the transverse drainage are unknown. We constructed the fluvial terrace sequence in the upper reach of the Hutuo drainage combined with thermoluminescence (TL) and optically stimulated luminescence (OSL) dating, as well as the timescale of the overlying loess-paleosol sequence. Our results reveal that (1) five terraces (T5-T1) developed along the upper reach of the Hutuo River, amongst which terraces T4-T1 were formed synchronously at ~ 600, ~ 120-130, ~ 20-26 and ~ 6-7 ka, respectively; (2) the creation of the transverse drainage and breach of the Xin-Ding paleolake occurred between ~ 600 and ~ 130 ka; and (3) the mechanism for the creation of the transverse drainage is via river piracy of paleostreams on both sides of the drainage divide. Localized differential uplift and associated tilting of the Xizhou Mountain block during the middle Pleistocene result in the formation of the transverse drainage and breach of the Xin-Ding paleolake.

  17. Exploring a Conceptual Model-Based Approach to Teaching Situated Word Problems: A Response to Yan Ping Xin and Dake Zhang

    ERIC Educational Resources Information Center

    Jitendra, Asha K.

    2011-01-01

    This article presents the author's response to Yan Ping Xin and Dake Zhang's recent critical evaluation of her and colleagues' work in "Exploring a Conceptual Model-Based Approach to Teaching Situated Word Problems," published in "The Journal of Educational Research" in 2009 (Vol. 102, No. 6). Most critiques of prior research are written in a fair…

  18. Effect and mechanisms of Gong-tone music on the immunological function in rats with Liver (Gan)-qi depression and Spleen (Pi)-qi deficiency syndrome in rats.

    PubMed

    Zhang, Shu-Yu; Peng, Gui-Ying; Gu, Li-Gang; Li, Zi-Mu; Yin, Sheng-Jun

    2013-03-01

    To investigate the effects and mechanisms of Gong-tone music on the immunological function in rats with the Chinese medicine syndrome of Liver (Gan)-qi stagnation and Spleen (Pi)-qi deficiency (LSSD). Twenty five male Wistar rats of SPF grade were randomly divided into 5 groups: normal group, model group, Xiaoyao Powder () group, Gong-tone group and combined group (the combination of Gong-tone and Xiaoyao Powder), with 5 rats in each group. The rat model for the Chinese medicine syndrome of LSSD was induced by chronic bandage and irregular diet. The course of treatment was 21 days. After the treatment, the levels of serum gastrin and IgG were detected by enzyme-linked immunoabsorbent assay (ELISA). Phagocytosis of macrophages was detected by the neutral red uptake assay and T cell proliferation was investigated by 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay. The serum gastrin, macrophage phagocytosis, IgG level and proliferation ability of T cells in the model group were significantly decreased compared with those in the normal group (P <0.05). Compared with those in the model group, the serum levels of gastrin, macrophage phagocytosis, IgG level and proliferation ability of T cells in Gong-tone, Xiaoyao Powder, and combined groups were significantly increased (P <0.05). The combined group was superior to either Gong-tone group or Xiaoyao Powder group. Gong-tone music may upregulate the immunological function and play a role in adjuvant therapy in the Chinese syndrome of LSSD.

  19. CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS.

    PubMed

    Wang, Yang; Wang, Weihao; Peng, Weijun; Liu, Weiping; Cai, Weijun; Xia, Zian; Zhang, Honggeng; Xing, And Zhihua

    2017-01-01

    Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored. The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities. The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size. The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties.

  20. Two-photon absorption of Tl1-xIn1-xSnxSe2 nanocrystallites

    NASA Astrophysics Data System (ADS)

    Myronchuk, Galyna; Parasyuk, Oleg; Piskach, Ludmila; Alzayed, Nasser Saleh; Prokhorenko, Serhii; Piasecki, Michal; Kityk, Iwan

    2016-12-01

    Novel materials for the infrared two-photon absorption — Tl1-xIn1-xSnxSe2 single crystals (x = 0.1,0.2) were grown. Two-photon absorption (TPA) was studied at CO2 laser wave-length 9.4μm with pulse duration 1μs. The studies were performed at different temperatures and for the nanocrystallite sizes varying within the 7-200 nm. The studies have shown that the TPA may be enhanced during the decrease of the nanocrystallite sizes below 50-60 nm. There exists also some critical x value at which the TPA value begin substantially to increase. The studied nanocrystallites are relatively stable to the infrared laser treatment and are not hygroscopic which allow to use them in different IR optoelectronic devices.

  1. Structural and microstructural investigation of CdxZn1-xIn2S4 photocatalyst for solar hydrogen production

    NASA Astrophysics Data System (ADS)

    Indrea, E.; Silipaş, D. T.; Bǎnicǎ, R.; Nyari, Terezia; Suciu, Ramona-Crina

    2012-02-01

    A novel low temperature hydrothermal synthesis of II-III2-VI4 (II = Zn, Cd; III = In; VI = S) mixed ternary chalcogenide semiconductors as visible photocatalysts for solar hydrogen production was performed. In this work, an X-ray diffraction based structural and microstructural study of chalcogenide semiconductors type CdxZn1-xIn2S4 (0 ≤ x ≤ 1) is reported. The investigated powder samples were synthesized by a hydrothermal technique, using a Teflon lined closed autoclave with self-generated pressure, at 180°C for 20 hours. Rietveld method based on pseudo-Voigt profile fitting function was applied to perform a simultaneous refinement of X-ray diffraction patterns concerning both material structure and microstructure. The Rietveld refinement of the X-ray diffraction data has been done using the MATCH, MAUD and PowderCel softwares.

  2. Realgar, cinnabar and An-Gong-Niu-Huang Wan are much less chronically nephrotoxic than common arsenicals and mercurials.

    PubMed

    Lu, Yuan-Fu; Wu, Qin; Yan, Jun-Wen; Shi, Jing-Zhen; Liu, Jie; Shi, Jing-Shan

    2011-02-01

    Realgar (As(4)S(4)) and cinnabar (HgS) are frequently included in traditional Chinese medicines and Indian Ayurvedic medicines. Both As and Hg are well known for toxic effects, and their safety is of concern. The aim of this study was to compare chronic nephrotoxicity of An-Gong-Niu-Huang Wan (AGNH), realgar and cinnabar with common arsenicals and mercurials. Mice were orally administrated with AGNH (3 g/kg, 6-fold of clinical dose), cinnabar (0.3 g/kg, amount in AGNH) and realgar (0.3 g/kg, amount in AGNH), HgCl(2) (0.118 mmol/kg, 1/10 of cinnabar), MeHg (0.012 mmol/kg, 1/100 of cinnabar), NaAsO(2) (As(3+) 0.028 mmol/kg, 1/100 of realgar) or Na(2)HAsO(4) (As(5+) 0.056 mmol/kg, 1/50 of realgar), daily for six weeks, and nephrotoxicity was examined. Animal body weights were decreased by MeHg and HgCl(2). Blood urea nitrogen and creatinine levels were elevated by MeHg. Renal pathology was severe in the MeHg and HgCl(2) groups, moderate in the arsenite, arsenate and realgar groups and mild in the cinnabar and AGNH groups. Renal Hg accumulation in the MeHg and HgCl(2) groups was 50-200 folds higher than the cinnabar group. Expressions of metallothionein-1 and heme oxygenase-1, biomarkers for metal toxicity, were increased 2-5 folds by arsenite, arsenate, MeHg and HgCl(2), but not by realgar, cinnabar and AGNH. The chemokine and glutathione-S transferase-α4, markers for inflammation, were also increased by MeHg and HgCl(2). Expressions of cell adhesion gene S100a9 and E-cadherin were altered by HgCl(2), arsenite and realgar. Taken together, chemical forms of mercury and arsenic are major determinants in their disposition and toxicity.

  3. U-Pb geochronology, geochemistry, and H-O-S-Pb isotopic compositions of the Leqingla and Xin'gaguo skarn Pb-Zn polymetallic deposits, Tibet, China

    NASA Astrophysics Data System (ADS)

    Wang, Liqiang; Cheng, Wenbin; Tang, Juxing; Kang, Haoran; Zhang, Yan; Li, Zhuang

    2016-01-01

    The Leqingla and Xin'gaguo deposits are two representative skarn Pb-Zn polymetallic deposits of the Gangdese Pb-Zn polymetallic belt, Tibet, China. LA-ICP-MS zircon U-Pb dating of the mineralization-related biotite granites from both the Leqingla and Xin'gaguo deposits yielded weighted mean ages of 60.8 Ma and 56.5 Ma, respectively, which can be inferred as their mineralization ages. The Leqingla biotite granite is characterized by high Al2O3, total Fe, Na2O, and low K2O. In comparison, the Xin'gaguo biotite granite is characterized by relative higher K2O but lower Al2O3, total Fe, and Na2O. Geochemical and mineralogical characteristics indicate that the Leqingla and Xin'gaguo biotite granites are calc-alkaline I-type granite and High K calc-alkaline I-type granite, respectively. Both the Leqingla and Xin'gaguo biotite granites are enrichment in LREE and LILEs and depletion in HFSEs, and they were formed at the India-Asia collision stage. δ18O and δD values for the Leqingla and Xin'gaguo deposits are -8.8‰ to 5.3‰ and -140.4‰ to -90.1‰, -4.5‰ to 7.0‰ and -117.3‰ to -81.0‰, respectively, indicating magma fluids mixed with meteoric water in ore-forming fluids. δ34S values (-11.6‰ to -0.3‰) of ore sulfides from the Leqingla deposit show characteristics of biogenetic sulfur isotope compositions, suggesting sulfur for the Leqingla deposit were sourced from wall rocks of the Mengla and Luobadui Formation, which are rich in organic materials. δ34S values of ore sulfides from the Xin'gaguo deposits show bimodal distribution (-5.0‰ to -1.6‰ and 1.6-2.1‰), indicating sulfur in the Xin'gaguo deposit were derived from both wall rocks and magma. In the Leqingla deposit, most ore sulfides have the similar Pb isotopic compositions with that of the mineralization-related biotite granite, suggesting the biotite granite supplied most of the ore-forming metals. Pb isotopic compositions of ore sulfides and Hf isotopic compositions of biotite granite show

  4. Comment on the paper "Extensive theoretical studies of a new energetic material: tetrazino-tetrazine-tetraoxide (TTTO)" by Xinli Song, Jicun Li, Hua Hou, and Baoshan Wang.

    PubMed

    Jorgensen, Kameron R; Wilson, Angela K

    2012-09-15

    Discrepancies are noted in the implementation and presentation of the ccCA methodology in a previous publication, "Extensive Theoretical Studies of a New Energetic Material: Tetrazino-tetrazine-tetraoxide (TTTO)" by Xinli Song, Jicun Li, Hua Hou, and Baoshan Wang. The enthalpy of formation for TTTO has been re-evaluated using the correct implementation of the ccCA methodology, demonstrating the results to be comparable to those of other ab initio composite methods. Copyright © 2012 Wiley Periodicals, Inc.

  5. QiShenYiQi Attenuates Renal Interstitial Fibrosis by Blocking the Activation of β-Catenin

    PubMed Central

    Li, Mei; Zhu, Fengxin; Zhang, Hao; Nie, Jing

    2016-01-01

    Chronic kidney disease (CKD) is becoming a worldwide problem. However, current treatment options are limited. In the current study we showed that QiShenYiQi (QSYQ), a water-ethanol extract from several Chinese medicines, is a potent inhibitor of renal interstitial fibrosis. QSYQ inhibited transforming growth factor-β1 (TGF-β1)-responsive α-smooth muscle actin (α-SMA), collagen I, and fibronectin up-regulation in obstructive nephropathy and cultured cells. Administration of QSYQ also inhibited the established renal interstitial fibrosis in obstructive nephropathy. Interestingly, QSYQ selectively inhibited TGF-β1-induced β-catenin up-regulation and downstream gene transcription. Taken together, our study suggests that QSYQ selectively inhibits TGF-β1-induced β-catenin up-regulation and might have significant therapeutic potential for the treatment of renal fibrosis. PMID:27636716

  6. [Textual research on Guang dong xin yu (New Sayings of Guangdong) quoted in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica].

    PubMed

    Zhang, Ruixian; Zhang, Wei; Li, Jian; Liang, Fei

    2014-05-01

    Altogether 15 terms for Guang dong xin yu (New Sayings of Guangdong) were used in Ben cao gang mu shi yi (Supplements to Compendium of Materia Medica), including Yue yu (Cantonese sayings), Chong yu (Sayings from Insect Drug), Jie yu (Sayings from Crustacean Drug), Xin yu (New Sayings), Yue hai xiang yu (Fragrant Sayings from Cantonese Region), Yue zhi mu yu (Sayings from Plants in Cantonese Annals), Guang dong suo yu (Trivial Sayings from Guangdong), Yue shan lu (Records of Cantonese Mountains), Yue lu (Cantonese Records), Jiao guang lu (Joint Guangdong Records), Yue cao zhi (Records of Cantonese Grasses), Guang guo lu (Records of Guangdong Fruits), Nan yue suo ji (Trivial Records of Southern Canton), Guang zhi (Guangdong Records), Yue zhi (Cantonese Records) etc. dealing with 57 sorts of drugs (with individual overlapping ones), the author of Xin yu was Qu Dajun, a surviving fogy of the Ming Dynasty actively involved in the activities to restore the old dynasty and resist the Qing Dynasty, and was persecuted in the literary inquisition in which his works were burnt so that Zhao Xuemin, when quoting his texts, had to go in a roundabout way.

  7. The phenomenology of solar-cycle-induced acoustic eigenfrequency variations: a comparative and complementary analysis of GONG, BiSON and VIRGO/LOI data

    NASA Astrophysics Data System (ADS)

    Chaplin, W. J.; Appourchaux, T.; Elsworth, Y.; Isaak, G. R.; New, R.

    2001-07-01

    We use high-quality helioseismic data collected by three different observational programmes during the declining phase of activity cycle 22,Q7 and a substantial portion of the rising phase of the current cycle (23), to study the phenomenological nature of the cycle-induced (centroid) eigenfrequency variations. We have analysed the frequency dependence of the shifts by fitting a power law of the form δνnl~(νnl)α/Enl to the data (where the Enl are the mode inertias, and α is the power-law index to be extracted). Previous studies have suggested that a relation with α=0 provides an adequate description of the shifts up to ν~3500μHz. However, here we show that while nevertheless describing the shifts well up to ~2500μHz, the linear scaling breaks down conspicuously at higher frequencies. Above this threshold, the shifts follow a power-law dependence with α~2. Our analyses (for 1600<=ν<=4000μHz) make use of observations made by the ground-based GONG over the angular degree range 4<=l<=150 the ground-based BiSON over 0<=l<=2 and the VIRGO/LOI instrument on board the ESA/NASA SOHO satellite over 0<=l<=8. We show that GONG shifts averaged over different ranges in l, together with the BiSON and LOI data averaged over their full quoted ranges, all scale at fixed frequency with the normalized mode inertia ratio QnlQ1. This is to be expected if the solar-cycle perturbation affecting the modes is confined in the surface layers; the excellent agreement also reflects favourably on the external consistency of the different observations.

  8. Satellite-derived land use changes along the Xin'an River watershed for supporting water quality investigation for potential fishing grounds in Qiandao Lake, China

    NASA Astrophysics Data System (ADS)

    Agapiou, Athos; Alexakis, Dimitrios D.; Sarris, Apostolos; Themistocleous, Kyriacos; Papoutsa, Christiana; Hadjimitsis, Diofantos G.

    2014-08-01

    It is estimated that more than 20,000 natural lakes are found across China. Most of these lakes are undergoing eutrophication or other severe environmental nuisances owing to natural and/or anthropogenic processes. In order to prevent or to minimize such damaging impacts, and to ascertain a proper quality management of the lake water and the associated fish resources, it is required to have access to up-to-date, accurate, and relevant data and information on the aquatic ecosystem in a timely manner. The "Dragon 3" project, supported by the European Space Agency, is focusing on Xin'an river watershed and investigates the impact of water quality and land cover/use change on the spatio-temporal distribution of the fishing grounds in Qiandao Lake. In this paper, the land use changes derived from satellite images is presented. Initially, Landsat 5 TM and Landsat 8 LDCM have been analyzed for the last 20 years in the vicinity of the Xin'an river watershed. Following the radiometric calibration of the images, several pixel-base classification algorithms have been evaluated including Spectral Angle Mapper (SAM), Support Vector Machine (SVM) as well Neural Network (NN). As it was found using the multi-temporal satellite imagery, the SVM algorithm was able to give high kappa accuracy estimated at around 0.90. In addition EO-Hyperion images over the western part of the Xin'an River were evaluated using hyperspectral vegetation indices as well using linear spectral un-mixing techniques. In addition, ENVISAT radar images have been evaluated in terms of land use change. The final outcomes indicate a significant urban expansion in the surrounding area of the Xin'an River which impacts the water quality investigation. Finally, a Landsat image was processed in order to estimate the Trophic State Index (TSI) values over the water bodies and the highest values were observed over the Xin'an river watershed and more specifically for the urban sites.

  9. Effect of kai xin san on learning and memory in a rat model of paradoxical sleep deprivation.

    PubMed

    Hu, Yuan; Liu, Ming; Liu, Ping; Yan, Juan-Juan; Liu, Ming-Yue; Zhang, Gang-Qiang; Zhou, Xiao-Jiang; Yu, Bing-Ying

    2013-04-01

    The present study aimed to evaluate the effect of kai xin san (KXS, at doses of 500, 250, and 125 mg/kg body weight per day), a well-known traditional Chinese medicine, on learning and memory in paradoxical sleep deprivation (PSD)-induced cognition deficit rats. Two behavior tests (the Open Field test and the Morris water maze task) were used for testing the effects of KXS on a PSD-induced learning and memory deficit model. Furthermore, its effect on the glutamic acid (GLU) and γ-amino-butyric acid (GABA) levels in the brain tissue, brain-derived neurotrophic factor (BDNF), cyclic AMP response element binding protein (CREB), and phosphorylated-CREB (p-CREB) expression in the hippocampus was also tested. KXS exerted the greatest cognition against the 48 h PSD-induced cognitive deficit and these effects may be mediated by decreasing the GLU and GABA levels and increasing the levels of BDNF, CREB, and p-CREB. This study indicates that the effect of KXS on learning and memory in a rat model of PSD could be associated with the modulation of neurotransmitter levels and the expression of some genes in the brain that contribute to memory functions.

  10. CARDIOPROTECTIVE ROLES OF THE CHINESE MEDICINAL FORMULA BAO-XIN-TANG ON ACUTE MYOCARDIAL INFARCTION IN RATS

    PubMed Central

    Wang, Yang; Wang, Weihao; Peng, Weijun; Liu, Weiping; Cai, Weijun; Xia, Zian; Zhang, Honggeng; Xing, and Zhihua

    2017-01-01

    Background: Bao-Xin-Tang (BXT) is a traditional Chinese medicinal formula used for the treatment of coronary heart disease and known to have favorable therapeutic benefits. The current study was designed to determine whether BXT has a cardioprotective role for acute myocardial infarction. The underlying mechanisms were also explored. Materials and Methods: The Sprague-Dawley rat model of acute myocardial infarction was established by occluding the left anterior descending branch of the coronary artery. After a 3-h ischemic period, we determined the myocardial infarction size, inflammatory components, and antioxidant activities. Results: The data showed that BXT could reduce the infarction size and lower the levels of C-reactive protein, interleukin-6, and myeloperoxidase, and increase the activities of superoxide dismutase and the anti-inflammatory cytokine, interleukin-10. These results indicate that administration of BXT, following acute myocardial infarction, could reduce infarct size. Conclusion: The effects of BXT may be related to its anti-inflammatory and anti-oxidative properties. PMID:28573223

  11. Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo

    PubMed Central

    Yin, Ya-Ling; Zhu, Mo-Li; Wan, Jia; Zhang, Chong; Pan, Guo-Pin; Lu, Jun-Xiu; Ping, Song; Chen, Yuan; Zhao, Fan-Rong; Yu, Hai-Ya; Guo, Tao; Jian, Xu; Liu, Li-Ying; Zhang, Jia-Ning; Wan, Guang-Rui; Wang, Shuang-Xi; Li, Peng

    2017-01-01

    Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia (XMJ) recouples eNOS to exert anti-atherosclerotic effects. Pretreatment of XMJ (25, 50, 100 μg/ml) for 30 minutes concentration-dependently activated eNOS, improved cell viabilities, increased NO generations, and reduced ROS productions in human umbilical vein endothelial cells incubated with H2O2 for 2 hours, accompanied with restoration of BH4. Importantly, these protective effects produced by XMJ were abolished by eNOS inhibitor L-NAME or specific eNOS siRNA in H2O2-treated cells. In ex vivo experiments, exposure of isolated aortic rings from rats to H2O2 for 6 hours dramatically impaired acetylcholine-induced vasorelaxation, reduced NO levels and increased ROS productions, which were ablated by XMJ in concentration-dependent manner. In vivo analysis indicated that administration of XMJ (0.6, 2.0, 6.0 g/kg/d) for 12 weeks remarkably recoupled eNOS and reduced the size of carotid atherosclerotic plaque in rats feeding with high fat diet plus balloon injury. In conclusion, XMJ recouples eNOS to prevent the growth of atherosclerosis in rats. Clinically, XMJ is potentially considered as a medicine to treat patients with atherosclerosis. PMID:28252100

  12. Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo.

    PubMed

    Yin, Ya-Ling; Zhu, Mo-Li; Wan, Jia; Zhang, Chong; Pan, Guo-Pin; Lu, Jun-Xiu; Ping, Song; Chen, Yuan; Zhao, Fan-Rong; Yu, Hai-Ya; Guo, Tao; Jian, Xu; Liu, Li-Ying; Zhang, Jia-Ning; Wan, Guang-Rui; Wang, Shuang-Xi; Li, Peng

    2017-03-02

    Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia (XMJ) recouples eNOS to exert anti-atherosclerotic effects. Pretreatment of XMJ (25, 50, 100 μg/ml) for 30 minutes concentration-dependently activated eNOS, improved cell viabilities, increased NO generations, and reduced ROS productions in human umbilical vein endothelial cells incubated with H2O2 for 2 hours, accompanied with restoration of BH4. Importantly, these protective effects produced by XMJ were abolished by eNOS inhibitor L-NAME or specific eNOS siRNA in H2O2-treated cells. In ex vivo experiments, exposure of isolated aortic rings from rats to H2O2 for 6 hours dramatically impaired acetylcholine-induced vasorelaxation, reduced NO levels and increased ROS productions, which were ablated by XMJ in concentration-dependent manner. In vivo analysis indicated that administration of XMJ (0.6, 2.0, 6.0 g/kg/d) for 12 weeks remarkably recoupled eNOS and reduced the size of carotid atherosclerotic plaque in rats feeding with high fat diet plus balloon injury. In conclusion, XMJ recouples eNOS to prevent the growth of atherosclerosis in rats. Clinically, XMJ is potentially considered as a medicine to treat patients with atherosclerosis.

  13. Donor states in a semimagnetic Cd1 -xinMnxin Te /Cd1 -xoutMnxout Te Double Quantum Well

    NASA Astrophysics Data System (ADS)

    Kalpana, Panneer Selvam; Nithiananthi, Perumal; Jayakumar, Kalyanasundaram

    2017-02-01

    The theoretical investigation has been carried out on the binding energy of donor associated with the electrons confined in a Cd1 -xinMnxin Te /Cd1 -xoutMnxout Te Double Quantum Well (DQW) as a function of central barrier width for various well dimensions and impurity locations in the barrier and the well. The magnetic field can act as a tool to continuously change the interwell coupling inside this DQW systems and its effect on donor binding has also been studied. Moreover, the polaronic corrections, which is due to the strong exchange interaction between the magnetic moment of Mn2+ ion and the spin of the confined carrier, to the binding energy of the hydrogenic donor impurity has also been estimated with and without the application of magnetic field. The binding energy of the donor impurity is determined by solving the Schrodinger equation variationally in the effective mass approximation and the effect due to Bound Magnetic Polaron (BMP) is included using mean field theory with the modified Brillouin function. The results are reported and discussed.

  14. VizieR Online Data Catalog: NIR spectroscopy of 1.5Shen, 2016)

    NASA Astrophysics Data System (ADS)

    Shen, Y.

    2016-04-01

    Our sample of quasars with near-IR spectroscopy consists of the 60 quasars at z~1.5-2.2 from Shen & Liu (2012, J/ApJ/753/125), and 14 additional quasars at z~3.3 for which we have obtained near-IR spectroscopy with the Folded-port InfraRed Echellett (FIRE) on the 6.5m Magellan-Baade telescope during two runs in 2013 May and December. These quasars were selected from the SDSS DR7 (Abazajian et al. 2009, II/294) quasar catalog (Shen et al. 2011, J/ApJS/194/45) with good optical spectra covering the CIV line and in redshift windows of z~1.5,2.1,3.3 such that the Hβ-[OIII] region can be covered in the JHK bands in the near-IR. (2 data files).

  15. Dynamics of the Gong windstorm (Jan 2013) in the context of a 20-year high-resolution simulation of Iberian climate

    NASA Astrophysics Data System (ADS)

    Miranda, Pedro M. A.; João Chinita, Maria; Cardoso, Rita; Soares, Pedro; Viterbo, Pedro; Pinto, Paulo; Mendes, Manuel

    2014-05-01

    In the last decade, Portugal was affected by a number of windstorms associated with mid-latitude cyclones, some with significant impact on built infrastructures, namely on the electric grid. Two of those storms were particularly violent, the Oeste storm on the 23 December 2009, and the Gong storm on 19 January 2013. The Klaus storm, on the 23 January 2009, had some impact but only in the northern edge of Iberia, but the Xinthia storm, on the 27 February 2010, had extensive impact in the Portuguese territory. Considering impacts on the electric grid, these 4 storms are part of a set of about 10 storms per decade, although earlier storms didn't get a name. The relevance of these extreme events in recent climate motivated a case study analysis of the more relevant storms and its analysis in a continuous regional climate simulation of the Iberian climate. The RCM simulation used WRF at 9km resolution, with ERA-Interim boundary conditions initially for the period 1989-2008, here extended until 28 Feb 2013. The former simulations were extensively validated against Iberian gridded temperature and precipitation datasets (Soares et al 2012), and against Portuguese station data (Cardoso et al 2013). Results are here validated, in the extended 24 year period, also against standard 10-m wind observations. Case study analysis used the same boundary conditions and model (WRF), but at both 9 and 3 km horizontal resolutions, and also included sensitivity experiments to different parametrizations. While the WRF RCM simulation, forced by ERA-Interim, presents an overall excellent performance in the representation of both the mean climate (temperature, precipitation and wind), and also in the representation of high-rank precipitation quantiles, the two most extreme windstorm events are not well represented. However, the Gong storm is very well represented in the case study simulation, even at 9km resolution with exactly the same boundary conditions, but a somewhat different initial

  16. Rapid HPLC Quantification Approach for Detection of Active Constituents in Modern Combinatorial Formula, San-Huang-Xie-Xin-Tang (SHXXT)

    PubMed Central

    Wu, Tung-Ying; Chang, Fang-Rong; Liou, Jing-Ru; Lo, I-Wen; Chung, Tang-Chia; Lee, Li-Yao; Chi, Chun-Chen; Du, Ying-Chi; Wong, Man-Hon; Juo, Suh-Hang Hank; Lee, Chun-Chen; Wu, Yang-Chang

    2016-01-01

    San-Huang-Xie-Xin-Tang (SHXXT), one of the most important traditional Chinese medicinal formulas, is comprised by three herbal medicines, the rhizome of Rheum officinale [or Rheum tanguticum (Polygonaceae) (Dahuang in Chinese)], the root of Scutellaria baicalensis (Labiatae) (Huangqin in Chinese), and the rhizome of Coptis chinensis (Ranunculaceae) (Huanglian in Chinese) in the ratios of 2:1:1 or 1:1:1. This study is aimed to quantitate and qualify of SHXXT, by a rapid, convenient, and effective HPLC-PDA approach associated with LC-MS technique. Of which method, nine chosen major bioactive components in SHXXT, including aloe-emodin (Ale), baicalin (Ba), berberine (Be), coptisine (Co), palmatine (Pa), resveratroloside (Res), rhein (Rh), sennoside A (Se-A), and wogonin (Wo), were evaluated within 30 min. The nine chemical markers were monitored in a high sensitivity with a low detection limit of 0.01−0.55 μg/mL and the correlation coefficient of the regression curve revealed a good linearity with R2 > 0.99. Moreover, the extraction solution system and the HPLC elution conditions were also optimized in the present study. This present developed protocol was then successfully applied to quantify nine chemical markers of 10 SHXXT products from eight Taiwanese TCM pharmaceutical companies. In quantitative results, Res was found as the major compound in SHXXT-1~5 and 8 with significantly higher amounts than those in other products, indicating the products SHXXT-1~5 and 8 may use R. tanguticum as the raw material, which possessed a higher concentration of the bioactive composition Res, instead of R. officinale. Simultaneously, Ale, Rh, and Wo were < 2% in these 10 products. Different chemical profiles of commercial products indicated that, probably, each product with the same named formula might be regarded as a sole medicine and need to be investigated individually. Importantly, it is never too much to emphasize the importance of quality control in TCM development. PMID

  17. Impacts of climate change on streamflows under RCP scenarios: A case study in Xin River Basin, China

    NASA Astrophysics Data System (ADS)

    Zhang, Yuqing; You, Qinglong; Chen, Changchun; Ge, Jing

    2016-09-01

    Researchers often examine hydro-climatological processes via Global Circulation Model (GCM) and hydrological model, which have been shown to benefit water resources management and prediction, especially at the basin scale. In this study, the Soil and Water Assessment Tool (SWAT) and Statistical Downscaling Method (SDSM) were integrated and applied to estimate streamflows in the Xin River Basin, China, based on climate change scenarios downscaled from different GCMs (BCC-CSM1.1, CanESM2, and NorESM1-M) under three Representative Concentration Pathways (RCPs). Results confirmed that the calibrated SWAT model accurately depicts hydrological processes features at daily, monthly, and yearly scales. Three GCMs based on the calibrated SDSM showed that temperature is continually increasing in the region, however, future precipitation is highly complex and uncertain; there were significant differences among various GCM RCP scenarios. The average of the precipitation in three models showed slight and steady increase trends under RCP2.6 and RCP4.5, but a significant increase under the RCP8.5 scenario. The ensemble average of streamflow in GCMs demonstrated that many RCPs significantly decrease from May to June but increase from August to September relative to the baseline period. The ensemble mean of the multi-GCM indicated that future streamflows under RCP2.6 and RCP4.5 scenarios will be closer to the current streamflow volume. Many RCPs also revealed a significant increase in monthly streamflow dispersion coefficient in October, reflecting a tendency for drought and flood events in that month. The BCC-CSM1.1 and NorESM1-M models showed that streamflows are higher than the baseline with median probability in the future. The low monthly streamflow (10th percentile) processes for each GCM were altogether similar to the baseline, whereas the high monthly streamflows (90th percentile) showed various levels of disparity compared to the baseline.

  18. [Effects of DanShenGuBao on biomechanical properties and bone mineral density of femur induced by retinoic acid in rats].

    PubMed

    Xu, Bilian; Cui, Liao; Chen, Wenshuang; Wei, Tianyou; Wu, Tie

    2010-04-01

    This investigation was directed to the effects of DanShenGuBao on biomechanical properties and bone mineral density (BMD) of femur induced by retinoic acid (RA) in rats. Forty 4-month-old virgin female Sprague-Dawley rats were randomly divided into 5 groups(8 rats each) control group, RA group and different doses of DanShenGuBao groups. Rats in control group were given vehicle, rats in other four groups were given RA at 70 mg x kg(-1) x d(-1) in the morning and given different drugs in the afternoon at the same time. Rats in RA group were given vehicle, rats in other groups were given different doses of DanShenGuBao which contained 10 mg x kg(-1) x d(-1), 5 mg x kg(-1) x d(-1), 2.5 mg x kg(-1) x d(-1) tanshinol, respectively. All of rats were treated at 5 ml x kg(-1) by oral gavaged for 28 days. In preparation for the determination of dynamic changes in bone tissues, all rats were given subcutaneous injections of 30 mg x kg(-1) tetracycline on the 14th, 13th day and 5 mg x kg(-1) calcein on the 4th, 3rd day before death. At the experimental endpoint, the rats were sacrificed by cardiac puncture under sodium pentobarbital anesthesia. Physical parameters, BMD and biomechanical properties of femur were assessed. Compared with those in control group, the physical parameters (cross-sectional diameter, wet and dry weight), BMD and biomechanical properties (max-load, elasticity-load, break-strain, rigid coefficient and bending-energe) were significantly decreased in RA group. Compared with that in RA group, the BMD of femur was increased significantly in medium and high dose of DanShenGuBao group, but there was no significant change in physical parameters and biomechanical properties of femur. RA could decrease the physical parameters, BMD and biomechanical properties of femur. DanShenGuBao could increase BMD, but it was found with no obvious effect on physical parameters and biomechanical properties.

  19. Qi-Shen-Yi-Qi Dripping Pills for the Secondary Prevention of Myocardial Infarction: A Randomised Clinical Trial

    PubMed Central

    Shang, Hongcai; Zhang, Junhua; Yao, Chen; Liu, Baoyan; Gao, Xiumei; Ren, Ming; Cao, Hongbao; Dai, Guohua; Weng, Weiliang; Zhu, Sainan; Wang, Hui; Xu, Hongjuan; Zhang, Boli

    2013-01-01

    Background. Several types of drugs have been recommended for the secondary prevention of myocardial infarction (MI). However, these conventional strategies have several limitations, such as low adherence, high cost, and side effects during long time use. Novel approaches to this problem are still needed. This trial aimed to test the effectiveness and safety of Qi-Shen-Yi-Qi Dripping Pills (QSYQ), a multi-ingredient Chinese patent medicine, for the secondary prevention of MI. Methods and Findings. A total of 3505 eligible patients were randomly assigned to QSYQ group (1746 patients) or aspirin group (1759). Patients took their treatments for 12 months. The final follow-up visit took place 6 months after the end of the trial drugs. The 12-month and 18-month estimated incidences of the primary outcome were 2.98% and 3.67%, respectively, in the QSYQ group. The figures were 2.96% and 3.81% in the aspirin group. No significant difference was identified between the groups. Conclusions. This trial did not show significant difference of primary and secondary outcomes between aspirin and QSYQ in patients who have had an MI. Though inconclusive, the result suggests that QSYQ has similar effects to aspirin in the secondary prevention of MI. PMID:23935677

  20. The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency

    PubMed Central

    Zhao, Hongyan; Li, Jian; He, Xiaojuan; Lu, Cheng; Xiao, Cheng; Niu, Xuyan; Zhao, Ning; Ju, Dahong; Lu, Aiping

    2012-01-01

    Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis (RA). In traditional Chinese medicine (TCM), the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state. In this study, TCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan Bi Pill (YJB), was used to treat collagen induced arthritis (CIA) rats with castration. Metabolomic technique was used to evaluate the pharmacological mechanism in castrated CIA rats treated by YJB. The results showed that castration significantly increased the severity of the arthritis in rats but was ameliorated by YJB. Its pharmacological mechanism was partially associated with lipid metabolites involving free fatty acid (FFA) and lysophosphatidylcholine (LPC). In conclusion, the experimental results demonstrate the protective effect of YJB on the TCM kidney deficiency pattern induced by androgen deficiency in CIA rats and support that YJB should be used for the clinical treatment of RA with TCM kidney deficiency pattern. PMID:22550538

  1. Effects of ning shen ling granule and dehydroepiandrosterone on cognitive function in mice undergoing chronic mild stress.

    PubMed

    Zhang, Xiao; Dong, Yi-long; Yang, Nan; Liu, Yan-yong; Gao, Rui-feng; Zuo, Ping-ping

    2007-03-01

    To investigate the changes of spontaneous and cognitive behavior, and cholinergic M receptors in the brain of mice subjected to chronic mild stress (CMS), and to determine the effect of Ning Shen Ling Granule (NSL) and dehydroepiandrosterone (DHEA) on them. CMS model mice were established by applying stress every day for 3 consecutive weeks with 7 kinds of unforeseeable stress sources, and they were medicated for 1 week beginning at the 3rd week of modeling. The changes in behavior were determined by Morris Water Maze and spontaneous movement test, and M-receptor binding activity in cerebral cortex, hippocampus and hypothalamus were measured by radioactive ligand assay with 3H-QNB. (1) The spontaneous movement in CMS model mice was significantly reduced, with the latency for searching platform in Morris Water Maze obviously prolonged (P<0.01), and these abnormal changes in behavior were improved in those treated with NSL and DHEA. (2) The binding ability of M-receptor in cerebral cortex and hippocampus of CMS mice was significantly decreased as compared with those in the control group (P<0.05), but could be restored to the normal level after intervention with NSL or DHEA. The decline of spontaneous movement and spatial learning and memory ability could be induced in animals by chronic mild stress, and that may be related to the low activity of central cholinergic M-receptors. Both NSL and DHEA could effectively alleviate the above-mentioned changes.

  2. [Research on infrared radiation characteristics of skin covering two acupuncture points in the hand and forearm, NeiGuan and LaoGong points].

    PubMed

    Wang, Zhen; Yu, Wenlong; Cui, Han; Shi, Huafeng; Jin, Lei

    2013-06-01

    In order to research the infrared radiation characteristics of the skin covering Traditional Chinese acupuncture points, which are NeiGuan in the forearm and LaoGong in the center of the palm, we detected continuously the infrared radiation spectra of the human body surface by using Fourier Transform Infrared Spectroscopy. The experimental results showed that firstly, the differences of the infrared radiation spectra of the human body surface were obvious between individuals. Secondly, the infrared radiation intensity of the human body surface changed with time changing. The infrared radiation intensity in two special wavelength ranges (wavelengths from 6. 79 microm to 6. 85 microm and from 13. 6 microm to 14. 0 microm) changed much more than that in other ranges obviously. Thirdly, the proportions of the infrared radiation spectra changed, which were calculated from the spectra of two different aupuncture points, were same in these two special wavelength ranges, but their magnitude changes were different. These results suggested that the infrared radiation of acupuncture points have the same biological basis, and the mechanism of the infrared radiation in these two special wavelength ranges is different from other tissue heat radiation.

  3. Qualitative and quantitative determination of YiXinShu Tablet using ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry.

    PubMed

    Sun, Zhi; Li, Zhuolun; Zuo, Lihua; Wang, Zhenhui; Zhou, Lin; Shi, Yingying; Kang, Jian; Zhu, Zhenfeng; Zhang, Xiaojian

    2017-08-24

    To clarify and quantify the chemical profile of YiXinShu Tablet rapidly, a feasible and accurate strategy was developed by applying ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry. A total of 105 components were identified, including 25 phenanthraquinones, 11 lactones, 19 lignans, 24 acids and 26 other compounds. Among them, 26 major compounds were unambiguously detected by comparing with reference standards. And 19 of these compounds in three batches of YiXinShu Tablet were selected for quantitative determination. (Z)-Ligustilide, salvianic acid A, salvianolic acid A, salvianolic acid B and rosmarinic acid were abundant in these three batches with contents over 1.000 mg/g. The established analysis methods were examined to be accurate and feasible. The results show that the ultra high performance liquid chromatography with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry method has a powerful qualitative ability and promising quantitative application. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  4. [Ecosystem service and economic valuation in the upper reaches of Xin' an River, Anhui, China for mitigating phosphorus nonpoint source pollution].

    PubMed

    He, Fang; Wu, Nan; Fang, Xiang-long; Gao, Ji-xi; Zhou, Xiao-tie; Feng, Chao-yang

    2015-04-01

    A model of phosphorus purification in a watershed was established based on the export coefficient and purification index of phosphorus in different types of land cover. The model was employed to simulate the economic value of the ecosystem service with the expected water quality standard and marginal cost of pollutant purification of the upper reaches of Xin' an River of Anhui, China. The results revealed that from 2000 to 2010, some farmland outside the Tunxi, Jixi, Shexian, Yixian and Xiuning was converted to built-up land. The total amount of phosphorus exported to the upper Xin' an River decreased a little, and the main source of phosphorus pollution was farmland and built-up land. More than half of the exported phosphorus was efficiently purified by different types of land cover via flow accumulation. The pattern of purification and export of highly concentrated phosphorus showed the same trend which occurred in the northern part of the watershed including the Yangzhi River, Fengle River and Hengjiang River. Forestland and grassland did not efficiently purify phosphorus in the watershed owing to the irrational distribution of existing land cover. The total service value was 3.80 and 3.31 million Yuan in 2000 and 2010, respectively.

  5. Critical thickness of MBE-grown Ga 1-xIn xSb ( x<0.2) on GaSb

    NASA Astrophysics Data System (ADS)

    Nilsen, T. A.; Breivik, M.; Selvig, E.; Fimland, B. O.

    2009-03-01

    Several Ga 1-xIn xSb layers, capped with 1 μm of GaSb, were grown on GaSb(0 0 1) substrates by molecular beam epitaxy in a Varian Gen II Modular system using either the conventional sample growth position with substrate rotation, or a tilted sample position with no substrate rotation. The GaInSb layers were examined by X-ray diffraction (XRD) using both symmetrical and asymmetrical reflections. The "tilted sample method" gave a variation of ±25% in thickness of the Ga 1-xIn xSb layers, while the indium (In) content varied by ±10% around the nominal value. The disappearance of thickness fringes in 004 XRD scans was used to determine the onset of relaxation, as determining the in-plane lattice constant for tilted samples was found to be difficult. Determining residual strain in samples grown by the tilted method was likewise found to be very difficult. The critical thickness for several In mole fractions between 5% and 19% was determined and was found to be from 2.2 to 2.7 times higher than predicted by Matthews and Blakeslee (1974) [J. Crystal Growth 27 (1974) 118] but lower than that predicted by People and Bean (1985) [Appl. Phys. Lett. 47 (1985) 322].

  6. The crystal and electronic structures of the Li2-xAg1+xIn3 (x=0.05) indide

    NASA Astrophysics Data System (ADS)

    Chumak, Ihor; Pavlyuk, Volodymyr; Dmytriv, Grygoriy; Pauly, Hermann; Ehrenberg, Helmut

    2013-01-01

    The crystal structure of Li2-xAg1+xIn3 (x=0.05) has been determined on a single crystal synthesized from the elements in a tantalum crucible. The compound crystallizes in orthorhombic space group Pmma (a=9.325 (3) Å, b=3.198 (1) Å, c=8.043 (3) Å at 296 K) with 12 atoms per unit cell and represents a new structure type. The structure of Li2-xAg1+xIn3 is closely related to the LaCoAl4 structure and belongs to the structural family, the representative members of which may be derived from the hexagonal AlB2 structure type by a combination of internal deformation and substitution. The strong In-In interaction and close to zero electrons concentration around Li and Ag atoms, calculated by LTMO, allow to suggest high mobility of lithium atoms located within the channels formed by the strongly waved [-In-In-] polyanionic chains.

  7. Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running.

    PubMed

    Cao, Yin; Hu, Yuan; Liu, Ping; Zhao, Hai-Xia; Zhou, Xiao-Jiang; Wei, Ying-Mei

    2012-01-06

    In traditional medicine, Kai Xin San (KXS), composed of ginseng (Panax ginseng), hoelen (Wolfiporia cocos), polygala (Polygala tenuifolia) and Acorus gramineus, is famous for the treatment of emotion-thought disease, such as settling fright, quieting the spirit and nourishing the heart. The present study investigated the effect of KXS on chronic fatigue syndrome (CFS) mice induced by forced wheel running. Seventy two healthy adult male Kunming mice were randomly divided into six groups: home cage control group, CFS group, CFS group with Modafinil treatment at 13 mg/kg/d doge, KXS treatment at 175 mg/kg/d, 350 mg/kg/d and 700 mg/kg/d doge. CFS mice were induced by forced wheel running with higher speed for 4 weeks and then taken an exhausted exercise. The biochemical parameters including serum lactate dehydrogenase (LDH), serum urea nitrogen (SUN), serum testosterone (T), liver glycogen (LG), muscle glycogen (MG) and muscle lactic acid (MLA) were determined by using commercially available kits. The splenocytes proliferation from mice was examined by MTT method. The levels of interleukin-2 (IL-2) and interleukin-4 (IL-4) secreted by splenocytes were determined by ELISA. CFS mice with KXS administration exhibited less electric shock time when compared with CFS group without drug treatment. The effect of KXS has after demonstrated reduction in SUN, LDH and MLA levels and an increase in T, LG and MG levels. CFS mice with KXS could improve the proliferation of splenocytes compared with CFS group without drug treatment. The cultured splenocytes from CFS mice without KXS supplementation produced more interleukin-2 (IL-2) but less interleukin-4 (IL-4) when compared with home cage control mice. The cultured splenocytes of CFS mice with KXS supplementation produced more interleukin-2 (IL-2) but less interleukin-4 (IL-4) when compared with CFS group without drug treatment. The results of this preliminary study provide evidence that KXS could ameliorate CFS by affecting the

  8. Realgar and realgar-containing Liu-Shen-Wan are less acutely toxic than arsenite and arsenate.

    PubMed

    Liu, Jie; Liang, Shi-Xia; Lu, Yuan-Fu; Miao, Jia-Wei; Wu, Qin; Shi, Jing-Shan

    2011-03-08

    Liu-Shen-Wan (LSW) is a widely-used traditional Chinese medicine containing realgar (As(4)S(4)). Realgar has been included in many traditional medicines, and is often taken as arsenite for risk assessment in realgar-containing traditional remedies. Is realgar toxicologically similar to arsenite? Mice were orally given LSW (60 and 200mg/kg; 200mg LSW contains 27 mg realgar), realgar (30 mg/kg, equivalent to 21 mg As/kg), and the equivalent As dose as sodium arsenite (NaAsO(2)), or as arsenate (Na(2)HAsO(4)). Acute toxicity and tissue As accumulation were determined 8h later. Arsenite and arsenate increased serum alanine aminotransferase (ALT) levels, indicative of liver injury; blood urea nitrogen (BUN) was also increased by arsenite and arsenate, indicative of nephrotoxicity. No elevations of ALT and BUN were observed in LSW and realgar groups. Histopathology showed more damage in arsenite- and arsenate-treated liver and kidneys, while in realgar- and LSW- treated animals, only mild alterations were seen. Hepatic and renal As contents were dramatically increased to 6200 and 3350ng/g, respectively, after arsenite, but only increased to 260 and 180 ng/g after LSW. The expressions of arsenic-sensitive stress genes, namely metallothionein-1 and heme oxygenase-1, were increased after arsenite or arsenate by 3-10-folds, but were unaltered after LWS and realgar. Realgar and LSW are much less toxic than arsenite and arenate. The use of total As content to evaluate the safety of realgar-containing traditional medicines is not scientifically sound. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  9. Ren Shen Yangrong Tang for Fatigue in Cancer Survivors: A Phase I/II Open-Label Study

    PubMed Central

    Xu, Yichen; Chen, Yanzhi

    2015-01-01

    Abstract Objectives: This open-label, prospective, phase I/II trial was performed to establish the safety and efficacy of Traditional Chinese Medicine (TCM) herbal products for treating non–anemia-related fatigue in patients with cancer. Although this practice is widespread in China, it has not been confirmed in a prospective clinical study. Design: Thirty-three patients who had completed cancer treatment, had stable disease and no anemia, and reported moderate to severe fatigue (rated ≥4 on a 0–10 scale) were enrolled in a TCM outpatient clinic. Patients took Ren Shen Yangrong Tang (RSYRT) decoction, a soup containing 12 TCM herbs, twice a day for 6 weeks. RSYRT aims to correct qi deficiency. Fatigue was assessed before and after RSYRT therapy, which all patients completed. Results: No discomfort or toxicity was observed. Before the study, all patients had had fatigue for at least 4 months. Fatigue severity decreased significantly from before therapy to 6 weeks after therapy: from 7.06 to 3.30 on a 0–10 scale (p<0.001). Fatigue category (mild, moderate, severe) shifted significantly (p=0.024): Of 22 patients with severe fatigue (rated ≥7) before therapy, 11 had mild fatigue and 11 had moderate fatigue after TCM treatment. The time-to-fatigue-alleviation was 2–3 weeks. Conclusion: RSYRT therapy was safe and was associated with fatigue improvement in nonanemic cancer survivors, consistent with historical TCM clinical practice experience. Because of a possible placebo effect in this open-label study, decoction RSYRT warrants further study in randomized clinical trials to confirm its effectiveness for managing moderate to severe fatigue. PMID:25918996

  10. Changes in urinary Cu, Zn, and Se levels in cancer patients after treatment with Sha Shen Mai Men Dong Tang.

    PubMed

    Lai, Tung-Yuan; Kuo, Hsien-Wen

    2016-04-01

    Sha Shen Mai Men Dong Tang (SMD-2; shā shēn mài dōng tāng) is a Chinese medicinal herb (CMH; zhōng cǎo yào) used to treat symptoms associated with cancer therapy. The objective of this study was to assess the effect of SMD-2 on the levels of urinary copper (Cu), zinc (Zn), and selenium (Se) in lung cancer patients and head and neck cancer patients receiving chemoradiotherapy. Forty-two head and neck cancer patients and 10 lung cancer patients participated in our clinical trial. Each patient received chemoradiotherapy for 4 weeks. In addition, each patient was treated with SMD-2 for 8 weeks, including 2 weeks prior to and after the chemoradiotherapy treatment. Comparison of urinary Cu, Zn, and Se levels and the ratios of Zn to Cu and Se to Cu at three time points in the two types of cancer were assessed using the generalized estimating equations (GEEs). After the patients received chemoradiotherapy for 4 weeks, SMD-2 treatment was found to be associated with a significant decrease in urinary Cu levels, whereas urinary Zn and Se levels increased significantly. In addition, the ratios of Zn to Cu and Se to Cu in the urine samples of these patients also increased significantly. Both the urinary Zn levels and the ratio of Zn to Cu in head and neck cancer patients were significantly higher than in lung cancer patients. Urinary Zn and Se levels and the ratios of Zn to Cu and Se to Cu, but not urinary Cu levels, increased significantly during and after treatment when assessed using the GEE model. The SMD-2 treatments significantly increased Zn and Se levels in the urine of head and neck cancer patients. Increased Zn and Se levels in urine strengthened immune system.

  11. Changes in urinary Cu, Zn, and Se levels in cancer patients after treatment with Sha Shen Mai Men Dong Tang

    PubMed Central

    Lai, Tung-Yuan; Kuo, Hsien-Wen

    2015-01-01

    Sha Shen Mai Men Dong Tang (SMD-2; 沙參麥冬湯 shā shēn mài dōng tāng) is a Chinese medicinal herb (CMH; 中草藥 zhōng cǎo yào) used to treat symptoms associated with cancer therapy. The objective of this study was to assess the effect of SMD-2 on the levels of urinary copper (Cu), zinc (Zn), and selenium (Se) in lung cancer patients and head and neck cancer patients receiving chemoradiotherapy. Forty-two head and neck cancer patients and 10 lung cancer patients participated in our clinical trial. Each patient received chemoradiotherapy for 4 weeks. In addition, each patient was treated with SMD-2 for 8 weeks, including 2 weeks prior to and after the chemoradiotherapy treatment. Comparison of urinary Cu, Zn, and Se levels and the ratios of Zn to Cu and Se to Cu at three time points in the two types of cancer were assessed using the generalized estimating equations (GEEs). After the patients received chemoradiotherapy for 4 weeks, SMD-2 treatment was found to be associated with a significant decrease in urinary Cu levels, whereas urinary Zn and Se levels increased significantly. In addition, the ratios of Zn to Cu and Se to Cu in the urine samples of these patients also increased significantly. Both the urinary Zn levels and the ratio of Zn to Cu in head and neck cancer patients were significantly higher than in lung cancer patients. Urinary Zn and Se levels and the ratios of Zn to Cu and Se to Cu, but not urinary Cu levels, increased significantly during and after treatment when assessed using the GEE model. The SMD-2 treatments significantly increased Zn and Se levels in the urine of head and neck cancer patients. Increased Zn and Se levels in urine strengthened immune system. PMID:27114935

  12. [Shen cha zheng ji yan fang (Inspection of the Collection of TCM Proved Prescriptions) , the first official collection of proved prescriptions in Modern China].

    PubMed

    Liu, Y; Zhang, P F; Chen, X J

    2017-01-28

    Yan Xishan, the local ruler of Shanxi Province in modern period, claiming that the folk TCM prescriptions should be collected, inspected and maintained because of its definite effect. The government of Shanxi Province provided a lot of resources in collecting TCM proved prescriptions since 1929. The TCM Improving Society of Shanxi made more effort on the inspecting process, with a reasonable incentive system and standardized methods established. As a result, the Shen cha zheng ji yan fang (Inspection of the Collection of TCM Proved Prescriptions) was published, characterized by the principles of "cheap, convenient and effective" . It was the beginning of official collection and collation of TCM proved prescriptions in modern China.

  13. Realgar- and cinnabar-containing an-gong-niu-huang wan (AGNH) is much less acutely toxic than sodium arsenite and mercuric chloride.

    PubMed

    Lu, Yuan-Fu; Yan, Jun-Wen; Wu, Qin; Shi, Jing-Zhen; Liu, Jie; Shi, Jing-Shan

    2011-01-15

    An-gong-niu-huang wan (AGNH) is a famous traditional Chinese medicine used for brain trauma, hemorrhage, and coma. AGNH contains 10% realgar (As₄S₄) and 10% cinnabar (HgS). Both As and Hg are well-known for their toxic effects, and the safety of AGNH is of concern. To address this question, the acute toxicity of AGNH, realgar and cinnabar were compared to sodium arsenite (NaAsO₂) and mercuric chloride (HgCl₂). Mice were administrated orally AGNH at 1, 3 and 6g/kg. AGNH at 3g/kg contains 2.8mmol As/kg as realgar and 1.18mmol Hg/kg as cinnabar. Realgar, cinnabar, arsenite (0.28 mmol/kg, 10% of realgar) and HgCl₂ (0.256 mmol/kg, 20% of cinnabar) were orally given to mice for comparison. Blood and tissues were collected 8h later for toxicity evaluation. Serum alanine aminotransferase was increased by arsenite and blood urea nitrogen was increased by HgCl₂. Total As accumulation after arsenite in liver (100-fold) and kidney (13-fold) was much higher than that after realgar. The accumulation of Hg after HgCl₂ in liver was 400-fold higher and kidney 30-fold higher than after cinnabar. Histopathology showed moderate liver and kidney injuries after arsenite and HgCl₂, but injuries were mild or absent after AGNH, realgar, and cinnabar. The expression of metallothionein-1, a biomarker of metal exposure, was increased 4-10-fold by arsenite and HgCl₂, but was unchanged by AGNH, realgar and cinnabar. Thus, AGNH, realgar and cinnabar are much less toxic acutely than arsenite and HgCl₂. The chemical forms of As and Hg are extremely important factors in determining their disposition and toxicity. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  14. Spatial variations of community structures and methane cycling across a transect of Lei-Gong-Hou mud volcanoes in eastern Taiwan

    PubMed Central

    Wang, Pei-Ling; Chiu, Yi-Ping; Cheng, Ting-Wen; Chang, Yung-Hsin; Tu, Wei-Xain; Lin, Li-Hung

    2014-01-01

    This study analyzed cored sediments retrieved from sites distributed across a transect of the Lei-Gong-Hou mud volcanoes in eastern Taiwan to uncover the spatial distributions of biogeochemical processes and community assemblages involved in methane cycling. The profiles of methane concentration and carbon isotopic composition revealed various orders of the predominance of specific methane-related metabolisms along depth. At a site proximal to the bubbling pool, the methanogenic zone was sandwiched by the anaerobic methanotrophic zones. For two sites distributed toward the topographic depression, the methanogenic zone overlaid the anaerobic methanotrophic zone. The predominance of anaerobic methanotrophy at specific depth intervals is supported by the enhanced copy numbers of the ANME-2a 16S rRNA gene and coincides with high dissolved Fe/Mn concentrations and copy numbers of the Desulfuromonas/Pelobacter 16S rRNA gene. Assemblages of 16S rRNA and mcrA genes revealed that methanogenesis was mediated by Methanococcoides and Methanosarcina. pmoA genes and a few 16S rRNA genes related to aerobic methanotrophs were detected in limited numbers of subsurface samples. While dissolved Fe/Mn signifies the presence of anaerobic metabolisms near the surface, the correlations between geochemical characteristics and gene abundances, and the absence of aerobic methanotrophs in top sediments suggest that anaerobic methanotrophy is potentially dependent on iron/manganese reduction and dominates over aerobic methanotrophy for the removal of methane produced in situ or from a deep source. Near-surface methanogenesis contributes to the methane emissions from mud platform. The alternating arrangements of methanogenic and methanotrophic zones at different sites suggest that the interactions between mud deposition, evaporation, oxidation and fluid transport modulate the assemblages of microbial communities and methane cycling in different compartments of terrestrial mud volcanoes. PMID

  15. Spatial variations of community structures and methane cycling across a transect of Lei-Gong-Hou mud volcanoes in eastern Taiwan.

    PubMed

    Wang, Pei-Ling; Chiu, Yi-Ping; Cheng, Ting-Wen; Chang, Yung-Hsin; Tu, Wei-Xain; Lin, Li-Hung

    2014-01-01

    This study analyzed cored sediments retrieved from sites distributed across a transect of the Lei-Gong-Hou mud volcanoes in eastern Taiwan to uncover the spatial distributions of biogeochemical processes and community assemblages involved in methane cycling. The profiles of methane concentration and carbon isotopic composition revealed various orders of the predominance of specific methane-related metabolisms along depth. At a site proximal to the bubbling pool, the methanogenic zone was sandwiched by the anaerobic methanotrophic zones. For two sites distributed toward the topographic depression, the methanogenic zone overlaid the anaerobic methanotrophic zone. The predominance of anaerobic methanotrophy at specific depth intervals is supported by the enhanced copy numbers of the ANME-2a 16S rRNA gene and coincides with high dissolved Fe/Mn concentrations and copy numbers of the Desulfuromonas/Pelobacter 16S rRNA gene. Assemblages of 16S rRNA and mcrA genes revealed that methanogenesis was mediated by Methanococcoides and Methanosarcina. pmoA genes and a few 16S rRNA genes related to aerobic methanotrophs were detected in limited numbers of subsurface samples. While dissolved Fe/Mn signifies the presence of anaerobic metabolisms near the surface, the correlations between geochemical characteristics and gene abundances, and the absence of aerobic methanotrophs in top sediments suggest that anaerobic methanotrophy is potentially dependent on iron/manganese reduction and dominates over aerobic methanotrophy for the removal of methane produced in situ or from a deep source. Near-surface methanogenesis contributes to the methane emissions from mud platform. The alternating arrangements of methanogenic and methanotrophic zones at different sites suggest that the interactions between mud deposition, evaporation, oxidation and fluid transport modulate the assemblages of microbial communities and methane cycling in different compartments of terrestrial mud volcanoes.

  16. ShenQi FuZheng Injection combined with chemotherapy in the treatment of colorectal cancer: A meta-analysis.

    PubMed

    Xu, Rongzhong; Lin, Liubing; Li, Yong; Li, Yan

    2017-01-01

    This study aims to investigate cellular immunity and clinical efficacy of ShenQi FuZheng Injection (SFI) in the associated chemotherapy of colorectal cancer (CRC). PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Full-text Database (VIP), WanFang Database and Chinese Biomedical Literature Database (CBM) searches were undertaken to identify randomized controlled trials of SFI plus chemotherapy versus chemotherapy alone in CRC patients. The quality of each trial was assessed according to the Jadad's scale, and Review Manager 5 was used to statisitically analyze the outcomes. Eight studies involving 722 patients were included in this review. The meta-analyses suggested there was a significantly higher overall response rate (OR 1.89; CI: 1.10-3.24; p = 0.02), grades of KPS (OR 2.35; CI: 1.55-3.56; p<0.01), CD3+cells (MD 10.29; CI: 8.46-12.12; p<0.01), CD4+cells (MD 7.06; CI: 5.33-8.794; p<0.01), CD4/CD8+cells (MD 0.32; CI: 0.25-0.40; p<0.01), NK+ (MD 7.20; CI: 2.02-12.37, p = 0.006), WBC (MD 1.24; CI: 0.59-1.89; p<0.01), HB (MD 14.55; CI: 7.47-21.63; p<0.01), and PLT (MD 19.05; CI: 4.29-33.81; p = 0.01), but lower severe toxicity for leukocytopenia (OR 0.37; CI: 0.17-0.80; p = 0.01), thrombocytopenia (OR 0.32; CI: 0.14-0.74; p = 0.008), gastrointestinal toxicity (OR 0.48; CI: 0.24-0.96; p = 0.04), when chemotherapy combined with SFI was compared with chemotherapy alone. There were similarities between two groups in liver dysfunction (OR 0.44; CI: 0.18-1.08; p = 0.07) and CD8+ (MD 0.54; CI: -1.89-2.96; p = 0.66). Also, there was presence of heterogeneity in the CD8 results; after the sensitivity analysis, the result of CD8+ was reversed (MD 1.57; CI: 0.32-2.81; p = 0.01). There was no significant publication bias across studies according to the Egger's (P = 0.19) and Begg's test (P = 0.23). SFI enhances chemotherapy efficiency as they are combined and used in the treatment of colorectal cancer patients. At the

  17. [Isolation and characterization of petroleum catabolic broad-host-range plasmids from Shen-Fu wastewater irrigation zone].

    PubMed

    Wang, Ya-Fei; Wang, Ya-Fei; Li, Hui; Li, Xiao-Bin

    2013-11-01

    Based on triparental mating, we isolated a total of eight broad host range (BHR) petroleum hydrocarbon catabolic plasmids from the soils, sediments, and wastewater samples in the Shen-Fu irrigation zone. The antibiotic resistance of the plasmids was tested, and then, the plasmids were transferred to Escherichia coli EC100. The plasmids carrying no antibiotic resistance were tagged by miniTn5 transposon consisting of antibiotic resistant genes. The PCR-based incompatibility test revealed that the pS3-2C and pS4-6G belonged to Inc P group, the pS3-2G, pW22-3G, and pA15-7G belonged to Inc N group, the pS7-2G was identified as Inc W plasmid, and the pA23-1G and pA10-1C were placed into Inc Q group. By adopting the reported PCR amplification methods of petroleum hydrocarbon-degrading catabolic genes, the petroleum-degrading capability of these BHR plasmids were preliminarily analyzed. The plasmids pS3-2G, pS7-2G, pA23-1G, pW22-3G, and pA10-1C carried aromatic ring- hydroxylating dioxygenase gene phdA and toluene monooxygenase gene touA; the plasmid pA15-7G carried touA and toluene dioxygenase gene tod; the plasmid pS3-2C carried ben, phdA, and tod; whereas the pS4-6G only carried ben. The host range test showed that all the isolated plasmids except pS3-2C could be transferred and maintained stably in the representative strains Agrobacterium tumefaciens C58, Cupriavidus necator JMP228, and E. coli EC100 of the alpha-, beta-, and gamma-Proteobacteria, respectively.

  18. Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats.

    PubMed

    Lv, Shi-Chao; Wu, Meifang; Li, Meng; Wang, Qiang; Wang, Xiao-Jing; Zhang, Ao; Xu, Ling; Zhang, Jun-Ping

    2017-04-01

    To observe the effect of QiShenYiQi pill (QSYQ) on myocardial collagen metabolism in experimental autoimmune myocarditis rats, and to explore its mechanism of action. Lewis rats underwent the injection of myocardial myosin mixed with freund's complete adjuvant were randomized into three groups: model, valsartan and QSYQ groups. And we treated rats which were injected phosphate buffered saline (PBS) mixed with freund's complete adjuvant as control group. Rats were intervened and euthanized at 4 and 8 weeks. We use alkaline hydrolysis to detect the content of myocardial hydroxyproline (HYP), and ELISA to detect the level of serum procollagen type I carboxyterminal peptide (PICP), procollagen type III amino-terminal peptide (PIIINP), and collagen C telopeptide type I (CTX-I). Myocardial MMP-1 and TIMP-1 protein expression was detected by immunohistochemistry, and myocardial MMP-1 and TIMP-1 mRNA expression was detected by real-time qPCR. QSYQ reduced the content of myocardial HYP, and this reduction was greater over time. QSYQ also reduced the serum concentration of PICP, PIIINP, CTX-I and the PICP/PIIINP ratio, which further reduced over time, whereas its effect on lowering PICP was significantly greater than that of valsartan at 4 and 8 weeks, and lowering CTX-I was significantly greater than that of valsartan at 8 weeks. In addition, after 4 weeks, QSYQ enhanced the protein and mRNA expression of MMP-1 and TIMP-1, and its effect on highering TIMP-1 was significantly greater than that of valsartan, whereas there was no significant difference in the expression of myocardial MMP-1 or TIMP-1 at 8 weeks. QSYQ reduced the ratio of MMP-1/TIMP-1, which further reduced over time, and the effect of QYSQ was significantly greater than that of valsartan after 4 weeks. This study provides evidence that QSYQ can reduce the rate of myocardial collagen synthesis and degradation. It also effectively improved the degree of myocardial fibrosis in experimental autoimmune myocarditis

  19. The memory enhancement effect of Kai Xin San on cognitive deficit induced by simulated weightlessness in rats.

    PubMed

    Qiong, Wang; Yong-Liang, Zhang; Ying-Hui, Li; Shan-Guang, Chen; Jiang-Hui, Gao; Yi-Xi, Chen; Ning, Jiang; Xin-Min, Liu

    2016-07-01

    It is vital for astronauts to develop effective countermeasures to prevent their decline of cognitive performance in microgravity to make space-flight missions successful. The traditional Chinese herbal formula Kai Xin San (KXS) has been used to treat amnesia for thousands years. It is a traditional complex prescription comprising of ginseng (Panax ginseng C. A. Meyer), hoelen (Poria cocos (Schw.) Wolf), polygala (Polygala tenaifolia Willd), and acorus (Acorus tatarinowii Schott). Previous study showed KXS could improve CMS-induced memory impairment in rats. In this paper, a unique environmental factor-microgravity (weightlessness) was simulated as hindlimb suspension (HLS) by tail in rats for two weeks as the HLS animal model. The KXS at the doses of 0.3 or 0.6g/kg p.o. daily was administrated to HLS rats for two weeks at the same time of HLS, the memory behavior tests were investigated with Morris water maze (MWM) and Shuttle Box (SB) test. The levels of ROS, 8-OHdG and 3-nitrotyrosine (3-NT) in the serum, and AChE and ChAT activity in the brain of rats were determined by ELISA or biochemical analysis. After HLS for two weeks, the escape latency and the swimming distance were significantly increased in the MWM test in rats in the HLS group, compared with control group. The percent of swimming distance in target quadrant and the number of target crossing was significantly decreased in rats in the HLS group compared with the control group. Performance in the SB test showed, the numbers and the distance of active avoidance was decreased from day 4 to day 7, the time spent in electric area was increased in rats in the HLS group compared with the control group. Administration of KXS 0.3 or 0.6g/kg to the HLS rats for two weeks significantly reduced the escape latency and the swimming distance, increased the percentage of swimming distance in target quadrant and the number of target crossings (P<0.01, compared with the HLS group) in the MWM test. Similar treatment with

  20. A critical courier role of volatile oils from Dalbergia odorifera for cardiac protection in vivo by QiShenYiQi.

    PubMed

    Yu, Jiahui; Zhang, Wen; Zhang, Yiqian; Wang, Yadong; Zhang, Boli; Fan, Guanwei; Zhu, Yan

    2017-08-04

    Component-based Chinese medicine (CCM) is derived from traditional Chinese medicine but produced with modern pharmaceutical standard and clearer clinical indications. However, it still faces challenges of defining individual component contribution in the complex formula. Using QiShenYiQi (QSYQ) as a model CCM, we investigated the role of Dalbergia odorifera (DO), an herbal component, in preventing myocardial damage. We showed that in vitro, QSYQ exerted considerable protective activities on cardiomyocytes from H2O2-induced mitochondrial dysfunction with or without DO. However, in isolated rat hearts, myocardial protection by QSYQ was significantly weakened without DO. In everted gut sac model, DO significantly enhanced absorption of the major QSYQ ingredients in different regions of rat intestine. Finally, in in vivo mouse model of doxorubicin (DOX)-induced myocardial damage, only QSYQ, but not QiShenYiQi without DO (QSYQ-DO), exerted a full protection. Taken together, our results showed that instead of directly contributing to the myocardial protection, Dalbergia odorifera facilitates the major active ingredients absorption and increases their efficacy, eventually enhancing the in vivo potency of QSYQ. These findings may shed new lights on our understanding of the prescription compatibility theory, as well as the impacts of "courier herbs" in component-based Chinese medicine.

  1. [Ameliorating effects of dan-shen and its major ingredient calcium/magnesium lithospermate B on cognitive deficiencies in senescence-accelerated mouse].

    PubMed

    Nomura, Y; Arima, T; Namba, T; Hattori, M; Kadota, S

    1997-10-01

    Effect of the long-term treatment with a Dan-Shen (Salviae miltiorrhizae radix) methanol extract (DME) or its major ingredient lithospermate B (LSB) on memory and learning in scenescence-accelerated mouse (SAM) was investigated by means of Morris's water maze task. DME or LSB treatment significantly decreased the escape latency in the P8 strain of SAM (SAMP8), which strain spontaneously develops learning deficits. These results suggest that DME and LSB treatment improved spacial learning. Neurochemical investigations indicated that both drugs did not affect the cholinergic system, but enhanced functions of the glutamate-PKC system in hippocampus, since the increases in [3H]MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo[a,b]-cyclohepten-5,10-imine maleate) binding in cortex and [3H]PDBu (phorbol 12,13-dibutyrate) binding in hippocampus were observed in DME and LSB treatments. Our previous studies indicate the decrease in PDBu binding and NMDA receptor-mediated functions in SAMP8 brain. Thus, it is suggested that 1) Methanol extract of Dan-Shen is effective for prevention of spacial learning deficit caused with aging, 2) lithospermate B is one of the active ingredients, 3) SAMP8 is useful model animal to investigate drugs for anti-aging or anti-dementia.

  2. Synthesis and thermoelectric properties of oxygen deficient fluorite derivative Ga3-xIn5+xSn2O16

    NASA Astrophysics Data System (ADS)

    Bhame, S. D.; Zhou, T.; Guilmeau, E.; Kinemuchi, Y.; Delorme, F.; Raveau, B.

    2010-11-01

    Exploring the possibility to obtain n-type oxide thermoelectrics, the transparent conducting oxide Ga3-xIn5+xSn2O16 (0.3

  3. Electronic structure of NaxCu1-xIn5S8 compounds: X-ray photoemission spectroscopy study and band structure calculations

    NASA Astrophysics Data System (ADS)

    Guillot-Deudon, Catherine; Harel, Sylvie; Mokrani, Arezki; Lafond, Alain; Barreau, Nicolas; Fernandez, Vincent; Kessler, John

    2008-12-01

    The aim of the present work is to complete a preliminary study concerning the electronic band structure investigations of NaxCu1-xIn5S8 compounds with 0≤x≤1 , which are expected to be formed at the Cu(In,Ga)Se2/In2S3 interface. The band structure calculations demonstrate that for the compounds containing both Na and Cu, as the Cu content increases the band gap tends to decrease, and x-ray photoemission spectroscopy measurements show that this variation is mainly due to valence-band-maximum shift along the solid solution. The band gap strongly depends on the nature of the monovalent cation, and the band structure calculations demonstrate that the d electrons of copper are responsible for the shift of the valence band. In addition, it is worth noting that the Cu-containing compounds have indirect gaps.

  4. Valence band structure calculations of GaAs/Ga xIn 1-xP strained-layer quantum wells

    NASA Astrophysics Data System (ADS)

    Zitouni, K.; Rerbal, K.; Kadri, A.

    1993-04-01

    Valence band structure of GaAs/Ga xIn 1-xP strained-layer quantum wells are investigated within an envelope function formalism which takes into account the valence subbands mixing through the Luttinger-Kohn Hamiltonian and the strain effects due to the lattice-mismatch through the Pikus-Bir Hamiltonian. For a Ga mole fraction x greater than 0.516 (compression), the top valence band is heavy-hole-like. For x less than 0.516 (tension strain), the top valence subband can be either heavy-hole-like or light-hole-like, depending on the well width and on the shear deformation potential. Interesting features are also obtained for the effective masses of the valence subbands from ɛ( K→) energy dispersion calculations along the in-plane K→ direction.

  5. A method coupled with remote sensing data to evaluate non-point source pollution in the Xin'anjiang catchment of China.

    PubMed

    Wang, Xuelei; Wang, Qiao; Wu, Chuanqing; Liang, Tao; Zheng, Donghai; Wei, Xingfeng

    2012-07-15

    Non-point source (NPS) pollution has been recognized as the largest threat to water resources throughout the world, and the evaluation of NPS loads is a priority. In China, some models, such as SWAT (Soil and Water Assessment Tools) model, have been widely used at the watershed scale. However, variations in natural and social factors make it difficult to find a proper model to use on NPS pollution management in China. In this study, a "Dualistic Structure" model is coupled with remote sensing data to capture the spatial and temporal processes of NPS pollution. Land parameters were derived from HJ-1A and HJ-1B satellite data (resolution 30 m), which offered greatly enhanced spatial resolution. This approach offers the advantage of being a rapid estimation system with fairly precise knowledge of the distribution, sources and quantities of NPS pollutants, and it can be used at the country scale, including in areas with insufficient data. The method is used in the Xin'anjiang catchment, an important water source for Hangzhou city, China. The simulation in this study includes the spatial distribution of monthly total nitrogen (TN), total phosphorous (TP), ammonia nitrogen (NH(4)-N) and chemical oxygen demand (COD(cr)) loads and the total production of NPS pollutants. The simulations were compared to pollution census (PC) data in 2010 and the results of SWAT model, with an average R(2) larger than 0.7. Additionally, the impacts of soil erosion and human activities on NPS pollution were assessed, indicating that soil and water conservation is very significant factor in the Xin'anjiang catchment. Results indicate that by coupling remote sensing data and parameter retrieval techniques to "Dualistic Structure" models, estimations of NPS loads on the catchment scale can be improved by spatial pixel-based modeling. This rapid NPS estimation system will offer effective support to policy makers for environmental management in China.

  6. Reply to the comments by Willem J. Zaadnoordijk on "An analytical solution for predicting the transient seepage from a subsurface drainage system" by P. Xin, H.C. Dan, T. Zhou, C. Lu, J. Kong, L. Li [Adv. Water Resour. 91 (2016) 1-10

    NASA Astrophysics Data System (ADS)

    Xin, Pei; Dan, Han-Cheng; Zhou, Tingzhang; Lu, Chunhui; Kong, Jun; Li, Ling

    2016-10-01

    We appreciate Willem J. Zaadnoordijk's comments, which led us to revisit the results in Xin et al. (2016). Zaadnoordijk (2016) solved numerically the Boussinesq equation-based (BE) model, Eq. (6) in Xin et al. (2016), and found that (1) the transient groundwater tables predicted by the numerical BE model didn't match Fig. 5b in Xin et al. (2016) and (2) with an adjusted effective specific yield (discussed further below), the BE model predicted similar results to the analytical solution that accounts for the unsaturated zone effects. We address these two points in the following. (1) The results of Fig. 5b in Xin et al. (2016) were calculated from the analytical solution with the unsaturated zone neglected. Although the governing equation of the saturated-unsaturated mathematical model presented in Xin et al. (2016) can be reduced to the Boussinesq equation with the unsaturated zone neglected (i.e., α and β approaching infinity), the application of the approximate analytical solution directly to this limiting condition incurs large errors as contained in Fig. 5b of Xin et al. (2016). In this reply we derive a new analytical solution separately for the BE model (detailed derivation given in the appendix) with such errors removed.

  7. Tai Chi and Qi Gong

    MedlinePlus

    ... to draw firm conclusions about this. Falling and Balance Exercise programs, including tai chi, may reduce falling ... effective than other forms of exercise for improving balance and stability in people with Parkinson’s disease. A ...

  8. Identification of the chemical constituents of Chinese medicine Yi-Xin-Shu capsule by molecular feature orientated precursor ion selection and tandem mass spectrometry structure elucidation.

    PubMed

    Wang, Hong-ping; Chen, Chang; Liu, Yan; Yang, Hong-Jun; Wu, Hong-Wei; Xiao, Hong-Bin

    2015-11-01

    The incomplete identification of the chemical components of traditional Chinese medicinal formula has been one of the bottlenecks in the modernization of traditional Chinese medicine. Tandem mass spectrometry has been widely used for the identification of chemical substances. Current automatic tandem mass spectrometry acquisition, where precursor ions were selected according to their signal intensity, encounters a drawback in chemical substances identification when samples contain many overlapping signals. Compounds in minor or trace amounts could not be identified because most tandem mass spectrometry information was lost. Herein, a molecular feature orientated precursor ion selection and tandem mass spectrometry structure elucidation method for complex Chinese medicine chemical constituent analysis was developed. The precursor ions were selected according to their two-dimensional characteristics of retention times and mass-to-charge ratio ranges from herbal compounds, so that all precursor ions from herbal compounds were included and more minor chemical constituents in Chinese medicine were identified. Compared to the conventional automatic tandem mass spectrometry setups, the approach is novel and can overcome the drawback for chemical substances identification. As an example, 276 compounds from the Chinese Medicine of Yi-Xin-Shu capsule were identified. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Qualitative and quantitative characterization of chemical constituents in Xin-Ke-Shu preparations by liquid chromatography coupled with a LTQ Orbitrap mass spectrometer.

    PubMed

    Peng, Jing-Bo; Jia, Hong-Mei; Liu, Yue-Tao; Zhang, Hong-Wu; Dong, Shu; Zou, Zhong-Mei

    2011-07-15

    Xin-Ke-Shu (XKS), a traditional Chinese medicine (TCM) preparation containing five herbal medicines, has been commonly used for the treatment of coronary heart disease in China. However, the chemical constituents in XKS have not been clarified yet. In order to quickly define the chemical profiles and control the quality of XKS preparations, liquid chromatography coupled with electrospray ionization hybrid linear trap quadrupole orbitrap (LC-LTQ-Orbitrap) mass spectrometry was applied for simultaneous identification and quantification of multi-constituent. A total of 51 compounds, including phenolic acids, isoflavone-C-glycosides, isoflavone-O-glycosides, flavonoids, and triterpenoid saponins, were identified or tentatively deduced on the base of their retention behaviors, MS and MS(n) data, or by comparing with reference substances and literatures. In addition, an optimized LC-ESI-MS method was established for quantitative determination of 15 marker compounds in XKS preparations from 7 independent pharmaceutical companies. The validation of the method, including spike recoveries, linearity, sensitivity (LOD and LOQ), precision, and repeatability, was carried out and demonstrated to be satisfied the requirements of quantitative analysis. This is the first report on the comprehensive determination of chemical constituents in XKS preparations by LC-LTQ-Orbitrap mass spectrometry. The results suggested that the established methods would be a powerful and reliable analytical tool for the characterization of multi-constituent in complex chemical system and quality control of TCM preparations. Copyright © 2011 Elsevier B.V. All rights reserved.

  10. Reclassification of Serpens flexibilis Hespell 1977 as Pseudomonas flexibilis comb. nov., with Pseudomonas tuomuerensis Xin et al. 2009 as a later heterotypic synonym.

    PubMed

    Shin, Su-Kyoung; Hwang, Chung Yeon; Cho, Yong-Joon; Yi, Hana

    2015-12-01

    Serpens flexibilis was proposed in 1977 and approved in 1980 without the 16S rRNA gene sequence information. The sequence of S. flexibilis became available in 2010, after the publication of Pseudomonas tuomuerensis in 2009. Our preliminary phylogenetic analyses indicated that these two strains share high sequence similarity and therefore showed strong potential to be united into a single species. To clarify the taxonomic status of the two species, a polyphasic taxonomy study was conducted including whole genome sequencing. The value of average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) between the genome sequences of S. flexibilis ATCC 29606(T) and P. tuomuerensis JCM 14085(T) were 98.1% and 89.0%, respectively. The phenotypic and chemotaxonomic properties including enzymatic activities, substrate utilization profiles, and fatty acids, supported that the two taxa have no pronounced difference and should thus constitute a single species. Therefore, we propose to transfer Serpens flexibilis Hespell 1977 to the genus Pseudomonas as Pseudomonas flexibilis comb. nov. (type strain=ATCC 29606(T)), with Pseudomonas tuomuerensis Xin et al. 2009 as a later heterotypic synonym of Pseudomonas flexibilis.

  11. Protective effect of ultrafiltered XinMaiJia extract against H₂O₂-induced injury in human umbilical vein endothelial cells through NHE1 downregulation.

    PubMed

    Yin, Y L; Li, P; Yang, J; Liu, D W; Sun, R L; Pan, G P; Wan, G M; Wan, G R

    2014-10-20

    We examined the protective effects of ultrafiltered XinMaiJia (XMJ) extract in a hydrogen peroxide (H2O2)-induced injury model in human umbilical vein endothelial cells (HUVECs) and determined the corresponding changes in the Na(+)-H(+) exchanger (NHE1) protein content and NHE1 gene expression. H2O2-induced HUVECs were treated with different concentrations of XMJ extract and the corresponding changes in morphology, activity, membrane permeability, biochemical indicators, cytokine concentration, NHE1 protein content, and NHE1 gene expression were determined. H2O2 significantly promoted HUVEC injury, whereas ultrafiltered XMJ extract significantly improved the morphological changes in injured HUVECs, increased their activity, and decreased NHE1 gene and protein expression, as well as limited the decrease in membrane permeability and expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, interleukin (IL)-1, IL-6, and nuclear factor-kB. Ultrafiltered XMJ extract inhibited H2O2-induced HUVEC injury by inhibiting NHE1 activity.

  12. Electronic and optical properties of Ga3-xIn5+xSn2O16: An experimental and theoretical study

    NASA Astrophysics Data System (ADS)

    Dolgonos, Alex; Lam, Kanber; Poeppelmeier, Kenneth R.; Freeman, Arthur J.; Mason, Thomas O.

    2014-01-01

    Experimental measurements of optical and electronic properties and local-density approximation (LDA) calculations on polycrystalline Ga3-xIn5+xSn2O16—the so-called "T-phase" in the Ga2O3-In2O3-SnO2 ternary system—have revealed it to be a good candidate for n-type transparent conducting oxide applications, particularly in the replacement of tin-doped indium oxide as a transparent electrode in organic photovoltaics. Room temperature conductivity of over 1000 S cm-1 was measured in polycrystalline bulk samples. Band structure calculations reveal a highly dispersed conduction band, corresponding to an electron effective mass of about 0.2 me. Normalized carrier mobility and concentration trends indicate that conductivity changes in T-phase are attributable to changes in carrier concentration, with mobility remaining relatively constant through the range of processing conditions and sample composition. Screened exchange LDA calculations yield a fundamental band gap of about 2.60 eV. A relatively constant optical band gap in the range of 2.9-3.0 eV along the range of T-phase composition was measured by diffuse reflectance of bulk samples, whereas ab-initio simulations predict a decreasing fundamental band gap with increasing In-to-Ga ratio. This is attributed to an increasing Burstein-Moss shift—corresponding to increasing free electron concentration—with increasing In-to-Ga ratio.

  13. A standardized chinese herbal decoction, kai-xin-san, restores decreased levels of neurotransmitters and neurotrophic factors in the brain of chronic stress-induced depressive rats.

    PubMed

    Zhu, Kevin Yue; Mao, Qing-Qiu; Ip, Siu-Po; Choi, Roy Chi-Yan; Dong, Tina Ting-Xia; Lau, David Tai-Wai; Tsim, Karl Wah-Keung

    2012-01-01

    Kai-xin-san (KXS), a Chinese herbal decoction being prescribed by Sun Simiao in Beiji Qianjin Yaofang about 1400 years ago, contains Ginseng Radix et Rhizoma, Polygalae Radix, Acori tatarinowii Rhizoma, and Poria. KXS has been used to treat stress-related psychiatric disease with the symptoms of depression and forgetfulness in ancient China until today. However, the mechanism of its antidepression action is still unknown. Here, the chronic mild-stress-(CMS-) induced depressive rats were applied in exploring the action mechanisms of KXS treatment. Daily intragastric administration of KXS for four weeks significantly alleviated the CMS-induced depressive symptoms displayed by enhanced sucrose consumption. In addition, the expressions of those molecular bio-markers relating to depression in rat brains were altered by the treatment of KXS. These KXS-regulated brain biomarkers included: (i) the levels of dopamine, norepinephrine, and serotonin (ii) the transcript levels of proteins relating to neurotransmitter metabolism; (iii) the transcript levels of neurotrophic factors and their receptors. The results suggested that the anti-depressant-like action of KXS might be mediated by an increase of neurotransmitters and expression of neurotrophic factors and its corresponding receptors in the brain. Thus, KXS could serve as alternative medicine, or health food supplement, for patients suffering from depression.

  14. A Standardized Chinese Herbal Decoction, Kai-Xin-San, Restores Decreased Levels of Neurotransmitters and Neurotrophic Factors in the Brain of Chronic Stress-Induced Depressive Rats

    PubMed Central

    Zhu, Kevin Yue; Mao, Qing-Qiu; Ip, Siu-Po; Choi, Roy Chi-Yan; Dong, Tina Ting-Xia; Lau, David Tai-Wai; Tsim, Karl Wah-Keung

    2012-01-01

    Kai-xin-san (KXS), a Chinese herbal decoction being prescribed by Sun Simiao in Beiji Qianjin Yaofang about 1400 years ago, contains Ginseng Radix et Rhizoma, Polygalae Radix, Acori tatarinowii Rhizoma, and Poria. KXS has been used to treat stress-related psychiatric disease with the symptoms of depression and forgetfulness in ancient China until today. However, the mechanism of its antidepression action is still unknown. Here, the chronic mild-stress-(CMS-) induced depressive rats were applied in exploring the action mechanisms of KXS treatment. Daily intragastric administration of KXS for four weeks significantly alleviated the CMS-induced depressive symptoms displayed by enhanced sucrose consumption. In addition, the expressions of those molecular bio-markers relating to depression in rat brains were altered by the treatment of KXS. These KXS-regulated brain biomarkers included: (i) the levels of dopamine, norepinephrine, and serotonin (ii) the transcript levels of proteins relating to neurotransmitter metabolism; (iii) the transcript levels of neurotrophic factors and their receptors. The results suggested that the anti-depressant-like action of KXS might be mediated by an increase of neurotransmitters and expression of neurotrophic factors and its corresponding receptors in the brain. Thus, KXS could serve as alternative medicine, or health food supplement, for patients suffering from depression. PMID:22973399

  15. Metabolism and Pharmacokinetics of San-Huang-Xie-Xin-Tang, a Polyphenol-Rich Chinese Medicine Formula, in Rats and Ex-Vivo Antioxidant Activity

    PubMed Central

    Shia, Chi-Sheng; Hou, Yu-Chi; Juang, Shin-Hun; Tsai, Shang-Yuan; Hsieh, Pei-Hsun; Ho, Lu-Ching; Chao, Pei-Dawn Lee

    2011-01-01

    San-Huang-Xie-Xin-Tang (SHXXT), a widely used Chinese herbal formula, consists of rhizomes of Rheum officinale, roots of Scutellaria baicalensis and rhizomes of Coptis chinesis. This study investigated the metabolism and pharmacokinetics of polyphenols in SHXXT, including baicalin, baicalein, wogonin, emodin, aloe-emodin, rhein and chrysophanol. The quantitation methods of SHXXT decoction and rat serum using high performance liquid chromatography were developed and validated in this study. After oral administration of SHXXT decoction to rats, the parent forms of various constituents and their conjugated metabolites in serum were determined before and after hydrolysis with β-glucuronidase and sulfatase. The results showed that only free form of rhein can be quantitated, whereas the parent forms of coptisine, palmatine, berberine, baicalein, wogonin, emodin, aloe-emodin and chrysophanol were not detected in serum. The glucuronides of baicalein, wogonin, emodin, aloe-emodin, rhein and chrysophanol were the predominant forms in bloodstream. In order to evaluate the in vivo antioxidant activity of SHXXT, the serum metabolite of SHXXT was prepared, characterized and followed by evaluation of the effect on AAPH-induced hemolysis. The results indicated that metabolites of SHXXT exhibited significant free radical scavenging activity. We suggest that biologists redirect their focus to the bioactivity of the conjugated metabolites of these polyphenols. PMID:19737807

  16. A Chinese herbal decoction, reformulated from Kai-Xin-San, relieves the depression-like symptoms in stressed rats and induces neurogenesis in cultured neurons

    PubMed Central

    Yan, Lu; Hu, Qinghua; Mak, Marvin S. H.; Lou, Jianshu; Xu, Sherry L.; Bi, Cathy W. C.; Zhu, Yue; Wang, Huaiyou; Dong, Tina T. X.; Tsim, Karl W. K.

    2016-01-01

    Kai-Xin-San (KXS), a Chinese herbal decoction for anti-depression, is a combination of paired-herbs, i.e. Ginseng Radix et Rhizoma (GR)-Polygalae Radix (PR) and Acori Tatarinowii Rhizoma (ATR)-Poria (PO). The make-up of the paired-herbs has been commonly revised according to syndrome differentiation and treatment variation of individual. Currently, an optimized KXS (KXS2012) was prepared by functional screening different combination of GR-PR and ATR-PO. The aim of this study was to verify the effect and underlying mechanism of KXS2012 against depression in chronic mild stress (CMS)-induced depressive rats and in primary cultures of neurons and astrocytes. In rat model, the CMS-induced depressive symptoms were markedly alleviated by the treatment with KXS2012. The CMS-suppressed neurotransmitter amounts were restored in the presence of KXS2012. And the expressions of neurotropic factors and its corresponding receptors were increased under KXS2012 administration. In cultured neurons, application of KXS2012 could promote neurogenesis by inducing the expression of synaptotagmin and dendritic spine density. Moreover, application of KXS2012 in cultured astrocytes, or in H2O2-stressed astrocytes, induced the expressions of neurotrophic factors: the increase might be associated with the modification of Erk1/2 and CREB phosphorylation. Our current results fully support the therapeutic efficacy of KXS2012 against depression in cell and animal models. PMID:27444820

  17. Protective effect of the ultra-filtration extract from Xin Mai Jia on human aortic smooth muscle cell injury induced by hydrogen peroxide

    PubMed Central

    WAN, JIA; YIN, YALING; SUN, RUILI; PAN, GUOPIN; LI, PENG; JIA, YANLONG; WAN, GUANGRUI; LIU, ZHANG-SUO

    2014-01-01

    The aim of the present study was to explore whether an ultra-filtration extract from Xin Mai Jia (XMJ), a Chinese medicinal formulation, has a protective effect on human aortic smooth muscle cell (HASMC) injury models induced by hydrogen peroxide (H2O2), and to consider the mechanism and efficacy of the therapeutic action of XMJ on atherosclerosis. HASMCs were injured by H2O2 and then exposed to various concentrations of XMJ. The morphological changes, growth, proliferation, migration and cytokine release of HASMCs were detected using 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT), an enzyme-linked immunosorbent assay and a scratch adhesion test. H2O2 significantly promoted the proliferation of HASMCs. The ultra-filtration extract from XMJ was observed to significantly attenuate the morphological changes of injured HASMCs, reduce the expression levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), interleukin (IL)-1, IL-6 and nuclear factor (NF)-κB, and increase the expression levels of matrix metalloproteinase (MMP)-2 and tissue inhibitor of metalloproteinase (TIMP). XMJ has clear anti-inflammatory and antioxidant effects, and significantly inhibits the proliferation and migration of HASMCs. PMID:24348756

  18. Standardized Chinese Formula Xin-Ke-Shu inhibits the myocardium Ca2+ overloading and metabolic alternations in isoproterenol-induced myocardial infarction rats

    PubMed Central

    Liu, Yue-Tao; Zhou, Chao; Jia, Hong-Mei; Chang, Xing; Zou, Zhong-Mei

    2016-01-01

    Xin-Ke-Shu (XKS) is a traditional Chinese patent medicine used for treatment of coronary heart diseases in China. However, its mechanism of action is still unclear. In this paper, the mediation of XKS on the isoproterenol (ISO)-induced myocardial infarction (MI) rat were evaluated based on a tissue-targeted metabonomics in vitro/vivo. The result indicated that twelve metabolic pathways were involved in the therapeutic effect of XKS in vivo, where seven pathways were associated with the Ca2+ overloading mechanism. In agreement with regulation on metabolic variations, XKS markedly reversed the over-expressions of three involved proteins including phospholipase A2 IIA (PLA2 IIA), calcium/calmodulin-dependent protein kinase II (CaMK II) and Pro-Caspase-3. The metabolic regulations of XKS on H9c2 cell also partially confirmed its metabolic effect. These metabolic characteristics in vitro/vivo and western blotting analysis suggested that XKS protected from MI metabolic perturbation major via inhibition of Ca2+ overloading mechanism. Furthermore, 11 active ingredients of XKS exerted steady affinity with the three proteins through the molecular docking study. Our findings indicate that the metabonomics in vitro/vivo combined with western blotting analysis offers the opportunity to gain insight into the comprehensive efficacy of TCMs on the whole metabolic network. PMID:27457884

  19. 3D geomechanical modeling and numerical simulation of in-situ stress fields in shale reservoirs: A case study of the lower Cambrian Niutitang formation in the Cen'gong block, South China

    NASA Astrophysics Data System (ADS)

    Liu, Jingshou; Ding, Wenlong; Yang, Haimeng; Wang, Ruyue; Yin, Shuai; Li, Ang; Fu, Fuquan

    2017-08-01

    An analysis of the in-situ state of stress in a shale reservoir was performed based on comprehensive information about the subsurface properties from wellbores established during the development of an oil and gas field. Industrial-level shale gas production has occurred in the Niutitang formation of the lower Cambrian Cen'gong block, South China. In this study, data obtained from hydraulic fracturing, drilling-induced fractures, borehole breakout, global positioning system (GPS), and well deviation statistics have been used to determine the orientation of the maximum horizontal principal stress. Additionally, hydraulic fracturing and multi-pole array acoustic logging (XMAC) were used to determine the vertical variations in the in-situ stress magnitude. Based on logging interpretation and mechanical experiments, the spatial distributions of mechanical parameters were obtained by seismic inversion, and a 3D heterogeneous geomechanical model was established using a finite element stress analysis approach to simulate the in-situ stress fields. The effects of depth, faults, rock mechanics, and layer variations on the principal stresses, horizontal stress difference (Δσ), horizontal stress difference coefficient (Kh), and stress type coefficient (Sp) were determined. The results show that the direction of the maximum principal stress is ESE 120°. Additionally, the development zones of natural fractures appear to correlate with regions with high principal stress differences. At depths shallower than 375 m, the stress type is mainly a thrust faulting stress regime. At depths ranging from 375 to 950 m, the stress type is mainly a strike-slip faulting stress regime. When the depth is > 950 m, the stress type is mainly a normal faulting stress regime. Depth, fault orientation, and rock mechanics all affect the type of stress. The knowledge regarding the Cen'gong block is reliable and can improve borehole stability, casing set point determination, well deployment

  20. Kai-Xin-San, a traditional Chinese medicine formulation, exerts antidepressive and neuroprotective effects by promoting pCREB upstream pathways

    PubMed Central

    Dong, Xian-Zhe; Wang, Dong-Xiao; Yu, Bing-Ying; Liu, Ping; Hu, Yuan

    2016-01-01

    Kai-Xin-San (KXS) is a traditional Chinese medicine that has been widely used for the treatment of emotion-related disease. However, the underlying mechanism remains largely unknown. The present study aimed to examine whether phospho-cAMP response element-binding protein (pCREB) and upstream components, such as extracellular signal-regulated kinase (ERK), phospho-ERK (pERK), phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), glycogen synthase kinase 3β (GSK3β) and pGSK3β are associated with the antidepressive effect of KXS. In total, 24 male Wistar rats were randomly divided into three groups, including control (n=8, no treatment), induced with chronic unpredictable mild stress (CMS) (n=8), and CMS rats treated with KXS at dosage of 370 mg/kg/day orally. Primary hippocampal neuronal cultures were prepared from Wistar rats for cell survival and proliferation assays. In KXS rats, increased protein expression levels of pCREB, BDNF and tyrosine receptor kinase B (TrkB) were observed in the hippocampus and prefrontal cortex, compared with the CMS model group. Furthermore, increased expression levels of ERK, pERK, PI3K, Akt, and GSK3β were also detected in the hippocampus and prefrontal cortex of KXS-treated rats compared with CMS model rats and in primary hippocampal neuronal cells treated with KXS. These results suggest that pCREB and upstream components, including TrkB/ERK/CREB and TrkB/PI3 K/CREB, may contribute to the antidepressive effect induced by KXS. Further studies are required to confirm these findings. PMID:27882154

  1. San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review

    PubMed Central

    Wu, Jiasi; Hu, Yingfan; Xiang, Li; Li, Sheng; Yuan, Yi; Chen, Xiaomei; Zhang, Yan; Huang, Wenge; Meng, Xianli; Wang, Ping

    2016-01-01

    Inflammatory disorders underlie varieties of human diseases. San-Huang-Xie-xin-Tang (SHXXT), composed with Rhizoma Rhei (Rheum palmatum L.), Rhizoma Coptidis (Coptis chinensis Franch), and Radix Scutellaria (Scutellaria baicalensis Georgi), is a famous formula which has been widely used in the fight against inflammatory abnormalities. Mutual reinforcement is one of the basic theories of traditional Chinese medicine. Here this article reviewed and analyzed the recent research on (1) How the main constituents of SHXXT impact on inflammation-associated signaling pathway molecules. (2) The interaction between the main constituents and efflux pumps or intestinal transporters. The goal of this work was to, (1) Provide evidence to support the theory of mutual reinforcement. (2) Clarify the key targets of SHXXT and suggest which targets need further investigation. (3) Give advice for the clinical use of SHXXT to elevated the absorption of main constituents and eventually promote oral bioavailability. We search literatures in scientific databases with key words of “each main SHXXT constituent,” in combination with “each main inflammatory pathway target molecule” or each main intestinal transporter, respectively. We report the effect of five main constituents on target molecules which lies in three main inflammatory signaling pathways, we as well investigate the interaction between constituents and intestinal transporter. We conclude, (1) The synergistic effect of constituents at both levels confirm the mutual reinforcement theory of TCM as it is proven in this work. (2) The effect of main constituents on downstream targets in nuclear need more further investigation. (3) Drug elevating the absorption of rhein, berberine and baicalein can be employed to promote oral bioavailability of SHXXT. PMID:27965575

  2. San-Huang-Xie-Xin-Tang Constituents Exert Drug-Drug Interaction of Mutual Reinforcement at Both Pharmacodynamics and Pharmacokinetic Level: A Review.

    PubMed

    Wu, Jiasi; Hu, Yingfan; Xiang, Li; Li, Sheng; Yuan, Yi; Chen, Xiaomei; Zhang, Yan; Huang, Wenge; Meng, Xianli; Wang, Ping

    2016-01-01

    Inflammatory disorders underlie varieties of human diseases. San-Huang-Xie-xin-Tang (SHXXT), composed with Rhizoma Rhei (Rheum palmatum L.), Rhizoma Coptidis (Coptis chinensis Franch), and Radix Scutellaria (Scutellaria baicalensis Georgi), is a famous formula which has been widely used in the fight against inflammatory abnormalities. Mutual reinforcement is one of the basic theories of traditional Chinese medicine. Here this article reviewed and analyzed the recent research on (1) How the main constituents of SHXXT impact on inflammation-associated signaling pathway molecules. (2) The interaction between the main constituents and efflux pumps or intestinal transporters. The goal of this work was to, (1) Provide evidence to support the theory of mutual reinforcement. (2) Clarify the key targets of SHXXT and suggest which targets need further investigation. (3) Give advice for the clinical use of SHXXT to elevated the absorption of main constituents and eventually promote oral bioavailability. We search literatures in scientific databases with key words of "each main SHXXT constituent," in combination with "each main inflammatory pathway target molecule" or each main intestinal transporter, respectively. We report the effect of five main constituents on target molecules which lies in three main inflammatory signaling pathways, we as well investigate the interaction between constituents and intestinal transporter. We conclude, (1) The synergistic effect of constituents at both levels confirm the mutual reinforcement theory of TCM as it is proven in this work. (2) The effect of main constituents on downstream targets in nuclear need more further investigation. (3) Drug elevating the absorption of rhein, berberine and baicalein can be employed to promote oral bioavailability of SHXXT.

  3. Qing-Xin-Jie-Yu Granules in addition to conventional treatment for patients with stable coronary artery disease (QUEST Trial): study protocol for a randomized controlled trial.

    PubMed

    Li, Shengyao; Guo, Ming; Mao, Huimin; Gao, Zhuye; Xu, Hao; Shi, Dazhuo

    2016-09-15

    Recurrent cardiovascular event remains high in stable coronary artery disease (SCAD), especially in patients with multiple risk factors, despite a high rate of use conventional treatment. Traditional Chinese Medicine (TCM) is a promising complementary and alternative medicine for treating SCAD, while evidence for its effect on long-term survival is limited. This study was designed to test if Chinese herbal medicine in addition to conventional treatment is more effective than conventional treatment alone in reducing major adverse cardiac event (MACE) for SCAD patients with multiple risk factors during a 1-year follow-up. This is a multicenter, placebo-controlled, double-blinded, randomized controlled clinical trial. A total of 1500 patients are randomized in a 1:1 ratio to receive the Qing-Xin-Jie-Yu Granules (QXJYG) or the placebo granules, twice daily for 6 months. The primary outcome is the combined outcomes including cardiac death, nonfatal myocardial infarction and revascularization. The secondary outcome is the combined outcomes including all-cause mortality, re-admission for acute coronary syndrome (ACS), heart failure, malignant supraventricular and ventricular arrhythmia influencing hemodynamics, ischemic stroke, and other thromboembolic events during 1-year follow-up. The assessment is performed at baseline (before randomization), 1, 3, 6, 9, and 12 months after randomization. This is the first multicenter trial sponsored by the national funding of China to evaluate TCM in combination with conventional treatment on 1-year survival in high-risk SCAD patients. If successful, it will provide an evidence-based complementary therapeutic approach for reducing MACE from SCAD. The trial was registered in the Chinese Clinical Trial Registry on December 28, 2013. The registration number is ChiCTR-TRC-13004370 .

  4. Quality evaluation of Guan-Xin-Ning injection based on fingerprint analysis and simultaneous separation and determination of seven bioactive constituents by capillary electrophoresis.

    PubMed

    Xu, Liying; Chang, Ruimiao; Chen, Meng; Li, Lou; Huang, Yayun; Zhang, Hongfen; Chen, Anjia

    2017-09-07

    The purpose of this study was to develop a comprehensive, rapid and practical capillary electrophoresis (CE) method for quality control (QC) of Guan-Xin-Ning (GXN) injection based on fingerprint analysis and simultaneous separation and determination of seven constituents. In fingerprint analysis, a capillary zone electrophoresis (CZE) method with a running buffer of 30 mM borate solution (pH 9.3) was established. Meanwhile, 10 batches of samples were used to establish the fingerprint electropherogram and 34 common peaks were obtained within 20 min. The RSD of relative migration times (RMT) and relative peak areas (RPA) were less than 5%. In order to further evaluate the quality of GXN injection, a micellar electrokinetic chromatography (MEKC) method was developed for simultaneous separation and determination of bioactive constituents. Seven components reached baseline separation with a running buffer containing 35 mM SDS and 45 mM borate solution (pH 9.3). A good linearity was obtained with correlation coefficients from 0.9906 to 0.9997. The LOD and LOQ ranged from 0.12 to 1.50 μg/mL and from 0.40 to 4.90 μg/mL, respectively. The recoveries ranged between 99.0 and 104.4%. Therefore, it was concluded that the proposed method can be used for full-scale quality analysis of GXN injection. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  5. Up-Regulation of CYP2C19 Expression by BuChang NaoXinTong via PXR Activation in HepG2 Cells

    PubMed Central

    Wu, Xiao-Ying; Wang, Huan; Qu, Qiang; Tan, Shen-Lan; Ruan, Jun-Shan; Qu, Jian; Chen, Hui

    2016-01-01

    Background Cytochrome P450 2C19 (CYP2C19) is an important drug-metabolizing enzyme (DME), which is responsible for the biotransformation of several kinds of drugs such as proton pump inhibitors, platelet aggregation inhibitors and antidepressants. Previous studies showed that Buchang NaoXinTong capsules (NXT) increased the CYP2C19 metabolic activity in vitro and enhanced the antiplatelet effect of clopidogrel in vivo. However, the underlying molecular mechanism remained unclear. In the present study, we examined whether Pregnane X receptor (PXR) plays a role in NXT-mediated regulation of CYP2C19 expression. Methods We applied luciferase assays, real-time quantitative PCR (qPCR), Western blotting and cell-based analysis of metabolic activity experiments to investigate the NXT regulatory effects on the CYP2C19 promoter activity, the mRNA/ protein expression and the metabolic activity. Results Our results demonstrated that NXT significantly increased the CYP2C19 promoter activity when co-transfected with PXR in HepG2 cells. Mutations in PXR responsive element abolished the NXT inductive effects on the CYP2C19 promoter transcription. Additionally, NXT incubation (150 and 250μg/mL) also markedly up-regulated endogenous CYP2C19 mRNA and protein levels in PXR-transfected HepG2 cells. Correspondingly, NXT leaded to a significant enhancement of the CYP2C19 catalytic activity in PXR-transfected HepG2 cells. Conclusion In summary, this is the first study to suggest that NXT could induce CYP2C19 expression via PXR activation. PMID:27467078

  6. Kai-Xin-San, a traditional Chinese medicine formulation, exerts antidepressive and neuroprotective effects by promoting pCREB upstream pathways.

    PubMed

    Dong, Xian-Zhe; Wang, Dong-Xiao; Yu, Bing-Ying; Liu, Ping; Hu, Yuan

    2016-11-01

    Kai-Xin-San (KXS) is a traditional Chinese medicine that has been widely used for the treatment of emotion-related disease. However, the underlying mechanism remains largely unknown. The present study aimed to examine whether phospho-cAMP response element-binding protein (pCREB) and upstream components, such as extracellular signal-regulated kinase (ERK), phospho-ERK (pERK), phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt), glycogen synthase kinase 3β (GSK3β) and pGSK3β are associated with the antidepressive effect of KXS. In total, 24 male Wistar rats were randomly divided into three groups, including control (n=8, no treatment), induced with chronic unpredictable mild stress (CMS) (n=8), and CMS rats treated with KXS at dosage of 370 mg/kg/day orally. Primary hippocampal neuronal cultures were prepared from Wistar rats for cell survival and proliferation assays. In KXS rats, increased protein expression levels of pCREB, BDNF and tyrosine receptor kinase B (TrkB) were observed in the hippocampus and prefrontal cortex, compared with the CMS model group. Furthermore, increased expression levels of ERK, pERK, PI3K, Akt, and GSK3β were also detected in the hippocampus and prefrontal cortex of KXS-treated rats compared with CMS model rats and in primary hippocampal neuronal cells treated with KXS. These results suggest that pCREB and upstream components, including TrkB/ERK/CREB and TrkB/PI3 K/CREB, may contribute to the antidepressive effect induced by KXS. Further studies are required to confirm these findings.

  7. Determination of mangiferin, jateorrhizine, palmatine, berberine, cinnamic acid, and cinnamaldehyde in the traditional Chinese medicinal preparation Zi-Shen pill by high-performance liquid chromatography.

    PubMed

    Dai, Ronghua; Li, Kang; Li, Qing; Bi, Kaishun

    2004-04-01

    High-performance liquid chromatography is employed to determine the contents of six marker components such as mangiferin, jateorrhizine, palmatine, berberine, cinnamic acid, and cinnamaldehyde in the traditional Chinese medicinal preparation Zi-Shen pill. The separation is performed on a C(18) column by stepwise gradient elution with water (0.2%, v/v, triethylamine adjusted to pH 4 with phosphoric acid)-methanol-acetonitrile (0.01 min, 98:0:2; 20 min, 80:5:15; 30 min, 65:13:22; and 55 min, 65:13:22) as the mobile phase at a flow rate of 0.9 mL/min, with UV detection at 280 nm. Six regression equations show good linear relationships between the peak area of each marker and concentration. The recoveries of the markers listed are 95.5%, 98.3%, 96.8%, 99.5%, 101.7%, and 102.1%, respectively. The repeatability and reproducibility (relative standard deviation) of the method are less than 2.5% and 3.3%, respectively.

  8. [Comparative study on the regulatory effects on senescence related cell cycle gene expression by TCM principles of tonifying shen, invigorating pi benefiting qi, and activating blood circulation].

    PubMed

    Chen, Fang-min; Zhao, Wei-kang; Xu, Pin-chu

    2003-11-01

    To compare the effects of TCM therapeutic principles of tonifying Shen (TS), benefiting Qi (BQ), invigorating Pi (IP) and activating blood circulation (ABC) herbs in regulating the gene expression in senescence related cell cycle. Drug sera containing TCM herbs of the above-mentioned principles were used to treat the aged human diploid fibroblast cell line 2BS. The effect of TCM on the senescence related cell cycle and its related gene expression (P16INK4, Cyclin D1 and PCNA) were examined by means of cell proliferative doublings, flow cytometry, RT-PCR and Western blot analysis. TCM herbs of TS and BQ could improve the cell cycle, down-regulate the P16 and Cyclin D1 mRNA/protein expression, up-regulate PCNA mRNA/protein expression, while TCM herbs of IP and ABC showed insignificant effect on these indexes. TCM herbs of TS and BQ have effect in improving cell cycle, it may be achieved through promoting the P16 pathway of gene expression.

  9. Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: a study protocol for a multicenter, randomized, controlled clinical trial.

    PubMed

    Peng, Nan; Zhang, Yi; Ma, Cong; Yu, Ming-Wei; Yang, Guo-Wang; Fu, Qi; Xu, Wei-Ru; Wang, Xiao-Min

    2014-05-15

    Aromatase inhibitors (AIs) are widely used as an adjuvant endocrine treatment in postmenopausal women with early-stage breast cancer. One of the main adverse effects of AIs is musculoskeletal symptoms, which leads to a lower quality of life and poor adherence to AI treatment. To date, no effective management of aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) has been developed. To determine whether the traditional Chinese medicine Yi Shen Jian Gu granules could effectively manage AIMSS we will conduct a multicenter, randomized, double-blind, placebo-controlled clinical trial. Patients experiencing musculoskeletal symptoms after taking AIs will be enrolled and treated with traditional Chinese medicine or placebo for 12 weeks. The primary outcome measures include Brief Pain Inventory-Short Form, Western Ontario and McMaster Universities Osteoarthritis Index, and Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands, which will be obtained at baseline and at 4, 8, 12 and 24 weeks. The results of this study will provide a new strategy to help relieve AIMSS. ISRCTN06129599 (assigned 14 August 2013).

  10. [Clinical effects of shen-nourishing and menstruation-regulating method combined with triptorelin acetate injection on patient with luteinized unruptured follicle syndrome].

    PubMed

    Yan-hua, Chen; Fang, Lian; Shi, Na

    2011-12-01

    To study the clinical effects of Shen-nourishing and menstruation-regulating method (SNMRM) combined with Triptorelin Acetate Injection (TAI) on patients with luteinized unruptured follicle syndrome (LUFS). Sixty-two LUFS patients were randomly assigned to the treatment group and the control group. TAI was given to patients in the control group while SNMRM + TAI was given to those in the treatment group. The ovulation rate and the pregnancy rate were observed in the two groups. The ovulation rate in the treatment group was higher than that in the control group, but without significant difference (85.53% versus 79.07%, P > 0.05). The pregnancy rate was significantly higher in the treatment group than in the control group (56.25% vs 30.00%, P < 0.05). Treatment of LUFS by SNMRM + TAI could improve the ovulation rate and the pregnancy rate, indicating that LUFS patients' ovary functions could be improved by using different menstruation regulating methods during different follicular development phases.

  11. [Effects of Chinese herbal medicine for supplementing Shen and strengthening the bone on rat distal femur cancellous bone in simulated weightlessness: an observation with scanning electron microscope].

    PubMed

    Sun, Ping; Huang, Zhen; Cai, De-hong; He, Lei; Wu, Chang-xing

    2007-09-01

    To observe the effect of Chinese herbal medicine for supplementing Shen and strengthening the bone on distal femoral trabecular ultrastructure of male rats subjected to simulated weightlessness. Fifteen male SD rats were randomized equally into 3 groups, including a control group (group A, in which the rats were allowed free movement) and two simulated weightlessness (via tail suspension) groups (group B and C). The rats in group C were treated with the commercially available Chinese herbal preparation, and those in the other two groups received normal saline at the same dose, for a treatment course of 28 days. Observation of trabeculae was performed with scanning electron microscopy. In group B, the trabeculae of the femur became thinner, fragile, discontinuous with reduced quantity as compared with those in group A. The rats in group C had greater number of the trabeculae than those in group B. Resorption surface decreased and the collagenous fiber were much more regular in group B. The Chinese herbal medicine may produce beneficial effect on bone microstructure of rats subjected to simulated weightlessness.

  12. Chinese Herbal Medicine (Zi Shen Qing) for Mild-to-Moderate Systematic Lupus Erythematosus: A Pilot Prospective, Single-Blinded, Randomized Controlled Study

    PubMed Central

    Zhong, Linda L. D.; Bian, Zhao Xiang; Gu, Jun Hua; Zhou, Xin; Tian, Yu; Mao, Jian Chun; Chen, Xiang Jun

    2013-01-01

    Objective. The aim of this study is to investigate the effectiveness and safety of a Chinese herbal formula Zi Shen Qing (ZSQ) in the treatment of systematic lupus erythematosus (SLE) in Chinese patients. Methods. A randomized controlled trial was conducted over 12 weeks in 84 Chinese patients who reported total scores of SLE Disease Activity Index-2000 (SLEDAI-2000) was from 5 to 14. The primary outcome was the changes of the SLEDAI-2000. The secondary outcomes included score changes of Chinese Medicine Syndromes (CMS), the changes of steroid dosage, the incidence of disease flare-up and biologic markers. Results. ZSQ significantly reduced SLEDAI-2000, the total scores of CMS in the treatment group compared with the controlled group (P < 0.05). Superiority of ZSQ over controlled group was also observed with greater improvement in the withdrawal dosage of corticosteroids and the incidence of disease flare-up (P < 0.05). There were no serious adverse events, and safety indices of whole blood counts, renal and liver functions were normal, both before and after the treatment. Conclusion. ZSQ is safe and effective for decreasing SLE disease activity and withdrawal dosage of corticosteroids in the mild to moderate SLE patients with “Deficiency of Qi and Yin” Pattern. PMID:23737826

  13. Influence of TCM therapy for supplementing Pi and nourishing Shen on dendritic cell function in patients with chronic hepatitis B treated by lamivudine.

    PubMed

    Zhang, Yong-Hua; Liu, Yi-Hui

    2009-02-01

    To observe the influence of traditional Chinese medicine (TCM) therapy for supplementing Pi () and nourishing Shen (, SPNS) on dendritic cell function in patients with chronic hepatitis B (CHB) treated by lamivudine. Sixty CHB patients with positive HBeAg were equally randomized by digital table into two groups: the observation group and the control group. Patients in the control group were treated with lamivudine only, while patients in the observation group were treated with lamivudine combined with SPNS fomula, for 12 weeks. The phenotype and function of dendritic cell, as well as its secretion factor interleukin 12 (IL-12) in all patients were determined after termination of therapy and the impacts on alanine transaminase (ALT) and HBVDNA were observed. The phenotypes of dendritic cells such as CD1a, CD80, CD86, human leukocyte antigen (HLA-DR) and intercellular adhesion molecule-1, as well as the levels of stimulation index (SI) and IL-12 were higher in the observation group than those in the control group (P<0.05 or P<0.01). Meanwhile, signififi cant difference between the two groups was also shown in the normalizing rates of ALT and HBV-DNA (P<0.05). TCM therapy for SPNS can signifificantly improve the function of dendritic cells in patients with CHB treated by lamivudine and enhance the early stage response of patients to the treatment.

  14. Effects of the traditional Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: a study protocol for a multicenter, randomized, controlled clinical trial

    PubMed Central

    2014-01-01

    Background Aromatase inhibitors (AIs) are widely used as an adjuvant endocrine treatment in postmenopausal women with early-stage breast cancer. One of the main adverse effects of AIs is musculoskeletal symptoms, which leads to a lower quality of life and poor adherence to AI treatment. To date, no effective management of aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) has been developed. Methods/design To determine whether the traditional Chinese medicine Yi Shen Jian Gu granules could effectively manage AIMSS we will conduct a multicenter, randomized, double-blind, placebo-controlled clinical trial. Patients experiencing musculoskeletal symptoms after taking AIs will be enrolled and treated with traditional Chinese medicine or placebo for 12 weeks. The primary outcome measures include Brief Pain Inventory-Short Form, Western Ontario and McMaster Universities Osteoarthritis Index, and Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands, which will be obtained at baseline and at 4, 8, 12 and 24 weeks. Discussion The results of this study will provide a new strategy to help relieve AIMSS. Trial registration ISCTN: ISRCTN06129599 (assigned 14 August 2013). PMID:24885324

  15. Protective Effects of Shen-Yuan-Dan, a Traditional Chinese Medicine, against Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro

    PubMed Central

    Liu, Hongxu; Shang, Juju; Chu, Fuyong; Li, Aiyong; Wu, Bao; Xie, Xinran; Liu, Weihong; Yang, Hongzhi; Tong, Tong

    2013-01-01

    Objectives. The study was to investigate the effects and mechanisms of Shen-Yuan-Dan (SYD) pharmacological postconditioning on myocardial ischemia/reperfusion (I/R) injury. Methods. In the in vivo experiment, myocardial injury markers and histopathology staining were examined. In the in vitro experiment, cell viability and cell apoptosis were, respectively, detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and Hoechst 33342 fluorochrome staining. The protein expressions of Bcl-2 and Bax were determined by immunocytochemistry assay. Results. Both low and high doses of SYD protected myocardium against I/R injury in rat model by reducing lactic dehydrogenase (LDH) and creatine kinase-MB (CK-MB) activity and malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activity and attenuating histopathology injury. Meanwhile, in the in vitro experiment, SYD promoted cell viability and inhibited the cardiomyocyte apoptosis. The level of Bcl-2 protein was restored to the normal level by SYD pharmacological postconditioning. In contrast, the Bax protein level was markedly reduced by SYD pharmacological postconditioning. These effects of SYD were inhibited by LY294002. Conclusions. The results of this study suggested that SYD pharmacological postconditioning has protective effects against myocardial I/R injury in both in vivo and in vitro models, which are related to activating the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway. PMID:24454518

  16. Si Shen Wan Inhibits mRNA Expression of Apoptosis-Related Molecules in p38 MAPK Signal Pathway in Mice with Colitis

    PubMed Central

    Zhao, Hai-Mei; Huang, Xiao-Ying; Zhou, Feng; Tong, Wen-Ting; Wan, Pan-Ting; Huang, Min-Fang; Ye, Qing; Liu, Duan-Yong

    2013-01-01

    Si Shen Wan (SSW) is used to effectively treat ulcerative colitis (UC) as a formula of traditional Chinese medicine. To explore the mechanism of SSW-inhibited apoptosis of colonic epithelial cell, the study observed mRNA expression of apoptosis-related molecules in p38 MAPK signal pathway in colonic mucosa in colitis mice treated with SSW. Experimental colitis was induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice; meanwhile, the mice were administrated daily either SSW (5 g/kg) or p38 MAPK inhibitor (2 mg/kg) or vehicle (physiological saline) for 10 days. While microscopical evaluation was observed, apoptosis rate of colonic epithelial cell and mRNA expression of apoptosis-related molecules were tested. Compared with colitis mice without treatment, SSW alleviated colonic mucosal injuries and decreased apoptosis rate of colonic epithelial cell, while the mRNA expressions of p38 MAPK, p53, caspase-3, c-jun, c-fos, Bax, and TNF-α were decreased in the colonic mucosa in colitis mice treated with SSW, and Bcl-2 mRNA and the ratio of Bcl-2/Bax were increased. The present study demonstrated that SSW inhibited mRNA expression of apoptosis-related molecules in p38 MAPK signal pathway to downregulate colonic epithelial cells apoptosis in colonic mucosa in mice with colitis. PMID:24223057

  17. ShenKang injection suppresses kidney fibrosis and oxidative stress via transforming growth factor-β/Smad3 signalling pathway in vivo and in vitro.

    PubMed

    Wu, Xiaoxiao; Guan, Yue; Yan, Jiajia; Liu, Meiyou; Yin, Ying; Duan, Jialin; Wei, Guo; Hu, Tianxin; Weng, Yan; Xi, Miaomiao; Wen, Aidong

    2015-08-01

    The purpose of this study is to investigate the antifibrosis and antioxidation of ShenKang injection (SKI) in vivo and in vitro and to evaluate potential mechanisms involved in the treatment of chronic kidney disease (CKD). In experimental animal studies, CKD was established by 5/6 nephrectomy (5/6Nx). Serum creatinine (Scr) and blood urea nitrogen (BUN) were determined. Histopathological tests were performed by H&E and Masson trichrome stained. The protein expressions of fibronectin (FN), collagen Ι, α-smooth muscle actin (α-SMA) and transforming growth factor-β (TGF-β) and phosphorylation of Smad3 were measured in 5/6Nx rats. In Human kidney proximal tubular cell line (HK-2) cells, the effects of TGF-β/Smad3 signalling pathway on renal fibrosis and oxidative injury were examined. 5/6Nx induced severe renal damages. Treatment of rats with SKI markedly reduced levels of Scr and BUN, alleviated expression of fibrosis-associated signalling molecules and reduced expression of TGF-β and phosphorylated Smad3. Meanwhile, in HK-2 cells, after exposure to TGF-β and H2 O2 , the protein expression of renal fibrosis was significantly increased. The generation of oxidative stress was also elevated. The severity of fibrosis and oxidative damage appears to be reduced after treatment with SKI. SKI inhibits renal fibrosis and oxidative stress through downregulation of TGF-β/Smad3 signalling pathway. © 2015 Royal Pharmaceutical Society.

  18. Protective Effects of Bu-Shen-Huo-Xue Formula against 5/6 Nephrectomy-Induced Chronic Renal Failure in Rats

    PubMed Central

    Lu, Jian-Rao; Han, Hai-Yan; Chen, Jie; Xiong, Chong-Xiang; Wang, Xin-Hua; Hu, Jing; Chen, Xiu-Feng; Ma, Li

    2014-01-01

    Chronic renal failure (CRF) is a serious disease related to increasing incidence and prevalence as well as decline in quality of life. Bu-Shen-Huo-Xue formula (BSHX), one of traditional herbal formulations, has been clinically employed to treat CRF for decades, but the mechanisms involved have not been investigated. In the present study, we investigated the effects of BSHX on some closely related parameters in 5/6 nephrectomy CRF rats. Rats with CRF were divided into five groups, namely, one control group, one enalapril group, and three BSHX treatment groups (0.25, 0.5, and 1 g/kg·d). The rats subjected to sham operation were used as a normal control. After eight weeks of treatment, BSHX significantly decreased the levels of Scr and BUN, downregulated the mRNA expression levels of TGF-β1, CTGF, NF-κB, TNF-α, and OPN, upregulated the mRNA expression of PPARγ, and reduced in situ expression of fibronectin and laminins. Histological findings also showed significant amelioration of the damaged renal tissue. BSHX protects 5/6 nephrectomy rats against chronic renal failure probably via regulating the expression of TNF-α, NF-κB, TGF-β1, CTGF, PPARγ, OPN, fibronectin, and laminins and is useful for therapy of CRF. PMID:24864155

  19. Effects of Chinese medicine shen-fu injection on the expression of inflammatory cytokines and complements during post-resuscitation immune dysfunction in a porcine model.

    PubMed

    Zhang, Qian; Li, Chun-sheng; Wang, Shuo; Gu, Wei

    2016-02-01

    To investigate the action of Shen-Fu Injection (SFI) in regulating the expression of the serum complements and inflammatory cytokines synthesized and released in response to the stress of global ischemia accompanying cardiac arrest (CA) and resuscitation. Thirty pigs were randomly divided into the sham (n=6) and 3 returns of spontaneous circulation (ROSC) groups (n=24). After 8-min untreated ventricular fibrillation and 2-min basic life support, 24 pigs of the ROSC groups were randomized into three groups (n=8 per group), which received central venous injection of SFI (SFI group), epinephrine (EP group), or saline (SA group). Hemodynamic status and blood samples were obtained at 0, 0.5, 1, 2, 4, 6, 12, and 24 h after ROSC. Serum concentrations of specific activation markers of the complement system C3, C4 and C5b-9 were increased during cardiopulmonary resuscitation through 24 h after ROSC. There were intense changes of various pro-inflammatory cytokines and anti-inflammatory cytokines as early as 0.5 h after CA. Compared with the EP and SA groups, SFI treatment reduced the proinflammatory cytokines levels of interleukin (IL)-6, IL-8 and tumor necrosis factor α (TNF-α, P<0.05), and increased the anti-inflammatory cytokine levels of IL-4 and IL-10 (P<0.05). Further, SFI treatment decreased the values of C3, C4 and C5b-9 compared with the EP and SA groups. SFI, derived from the ancient Chinese medicine, has significant effects in attenuating post-resuscitation immune dysfunction by modulating the expression of complements and cytokines levels. The current study provided an experimental basis for the clinical application of a potential pharmacologic target for post resuscitation immune dysfunction.

  20. A Network Pharmacology Study of Chinese Medicine QiShenYiQi to Reveal Its Underlying Multi-Compound, Multi-Target, Multi-Pathway Mode of Action

    PubMed Central

    Li, Xiang; Wu, Leihong; Liu, Wei; Jin, Yecheng; Chen, Qian; Wang, Linli; Fan, Xiaohui; Li, Zheng; Cheng, Yiyu

    2014-01-01

    Chinese medicine is a complex system guided by traditional Chinese medicine (TCM) theories, which has proven to be especially effective in treating chronic and complex diseases. However, the underlying modes of action (MOA) are not always systematically investigated. Herein, a systematic study was designed to elucidate the multi-compound, multi-target and multi-pathway MOA of a Chinese medicine, QiShenYiQi (QSYQ), on myocardial infarction. QSYQ is composed of Astragalus membranaceus (Huangqi), Salvia miltiorrhiza (Danshen), Panax notoginseng (Sanqi), and Dalbergia odorifera (Jiangxiang). Male Sprague Dawley rat model of myocardial infarction were administered QSYQ intragastrically for 7 days while the control group was not treated. The differentially expressed genes (DEGs) were identified from myocardial infarction rat model treated with QSYQ, followed by constructing a cardiovascular disease (CVD)-related multilevel compound-target-pathway network connecting main compounds to those DEGs supported by literature evidences and the pathways that are functionally enriched in ArrayTrack. 55 potential targets of QSYQ were identified, of which 14 were confirmed in CVD-related literatures with experimental supporting evidences. Furthermore, three sesquiterpene components of QSYQ, Trans-nerolidol, (3S,6S,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol and (3S,6R,7R)-3,7,11-trimethyl-3,6-epoxy-1,10-dodecadien-7-ol from Dalbergia odorifera T. Chen, were validated experimentally in this study. Their anti-inflammatory effects and potential targets including extracellular signal-regulated kinase-1/2, peroxisome proliferator-activated receptor-gamma and heme oxygenase-1 were identified. Finally, through a three-level compound-target-pathway network with experimental analysis, our study depicts a complex MOA of QSYQ on myocardial infarction. PMID:24817581

  1. Qi-Shen-Yi-Qi Dripping Pills Promote Angiogenesis of Ischemic Cardiac Microvascular Endothelial Cells by Regulating MicroRNA-223-3p Expression

    PubMed Central

    Dai, Guo-Hua; Liu, Ning; Zhu, Jing-Wei; Yao, Jing; Yang, Chun; Ma, Pei-Ze; Song, Xian-Bo

    2016-01-01

    Traditional Chinese medicine (TCM) research shows that Qi-Shen-Yi-Qi Dripping Pills (QSYQ) can promote ischemic cardiac angiogenesis. Studies have shown that microRNAs (miRNAs) are the key component of gene regulation networks, which play a vital role in angiogenesis and cardiovascular disease. Mechanisms involving miRNA by which TCM promotes ischemic cardiac angiogenesis have not been reported. We found that microRNA-223-3p (mir-223-3p) was the core miRNA of angiogenesis of rats ischemic cardiac microvascular endothelial cells (CMECs) and inhibited angiogenesis by affecting RPS6KB1/HIF-1α signal pathway in previous study. Based on the results, we observed biological characteristics and optimal dosage for QSYQ intervening in rats ischemic CMECs angiogenesis and concluded that QSYQ low-dose group had the strongest ability to promote angiogenesis of ischemic myocardium. Using miRNA chip and real-time PCR techniques in this study, we identified mir-223-3p as the pivotal miRNA in QSYQ that regulated angiogenesis of ischemic CMECs. From real-time PCR and western blot analysis, research showed that gene and protein expression of factors located RPS6KB1/HIF-1α signaling pathway, including HIF-1α, VEGF, MAPK, PI3K, and AKT, were significantly upregulated by QSYQ to regulate angiogenesis of ischemic CMECs. This study showed that QSYQ promote ischemic cardiac angiogenesis by downregulating mir-223-3p expression in rats ischemic CMECs. PMID:27057198

  2. Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4+CD25+ regulatory T cells

    PubMed Central

    Li, Jingya; Zhao, Ruizhen; Li, Xiaoli; Sun, Wenjun; Qu, Miao; Tang, Qisheng; Yang, Xinke; Zhang, Shujing

    2016-01-01

    Background Shen-Qi-Jie-Yu-Fang (SJF) is composed of eight Chinese medicinal herbs. It is widely used in traditional Chinese medicine for treating postpartum depression (PPD). Previous studies have shown that SJF treats PPD through the neuroendocrine mechanism. Aim To further investigate the effect of SJF on the immune system, including the inflammatory response system and CD4+CD25+ regulatory T (Treg) cells. Materials and methods Sprague Dawley rats were used to create an animal model of PPD by inducing hormone-simulated pregnancy followed by hormone withdrawal. After hormone withdrawal, the PPD rats were treated with SJF or fluoxetine for 1, 2, and 4 weeks. Levels of Treg cells in peripheral blood were measured by flow cytometry analysis. Serum interleukin (IL)-1β and IL-6 were evaluated by enzyme-linked immunosorbent assay, and gene and protein expressions of IL-1RI, IL-6Rα, and gp130 in the hippocampus were observed by reverse-transcription polymerase chain reaction and Western blot. Results Serum IL-1β in PPD rats increased at 2 weeks and declined from then on, while serum IL-6 increased at 1, 2, and 4 weeks. Both IL-1β and IL-6 were downregulated by SJF and fluoxetine. Changes in gene and protein expressions of IL-1RI and gp130 in PPD rats were consistent with changes in serum IL-1β, and were able to be regulated by SJF and fluoxetine. The levels of Treg cells were negatively correlated with serum IL-1β and IL-6, and were decreased in PPD rats. The levels of Treg cells were increased by SJF and fluoxetine. Conclusion Dysfunction of proinflammatory cytokines and Tregs in different stages of PPD was attenuated by SJF and fluoxetine through the modulation of serum concentrations of IL-1β and IL-6, expressions of IL-1RI, and gp130 in the hippocampus, and CD4+CD25+ Treg cells in peripheral blood. PMID:27143890

  3. Shen-Qi-Jie-Yu-Fang has antidepressant effects in a rodent model of postpartum depression by regulating the immune organs and subsets of T lymphocytes

    PubMed Central

    Qu, Miao; Tang, Qisheng; Li, Xiaoli; Zhao, Ruizhen; Li, Jingya; Xu, Hong; Gao, Yushan; Mao, Yingqiu

    2015-01-01

    Background Shen-Qi-Jie-Yu-Fang (SJ Fang) is a herbal preparation used in traditional Chinese medicine, and is a potentially important new therapeutic agent in postpartum depression (PPD). Previously, we have elucidated the effects of SJ Fang on hormone receptors and monoamine neurotransmitters involved in the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes in PPD rats. However, the immune-modulating effects of SJ Fang in PPD are still unknown. In this study, we explored the effects of SJ Fang on the immune organs and subsets of T lymphocytes in PPD rats. Methods PPD was created in Sprague-Dawley rats by inducing hormone-simulated pregnancy followed by hormone withdrawal. After hormone withdrawal, the PPD rats were then treated with fluoxetine at 1, 2, and 4 weeks, and the SJ Fang rats were also treated at 1, 2, and 4 weeks. Depressive behavior in the rats was evaluated by the forced swim test, sucrose consumption test, and open field test. The thymus index and spleen index were calculated. Hematoxylin-eosin staining was used to identify pathological features in the thymus and spleen. CD3, CD4, and CD8 lymphocyte subsets were analyzed by flow cytometry. Results Both fluoxetine and SJ Fang decreased immobility time, increased sucrose consumption, an horizontal and vertical movement. After 4 weeks of treatment with fluoxetine or SJ Fang, the thymus index and spleen index were significantly higher than at baseline, and the morphology of the thymus and spleen were returning to normal. Two weeks after hormone withdrawal, subsets of T lymphocytes indicated a shift from immune activation to immune suppression, which was reversed by 4 weeks of treatment with fluoxetine or SJ Fang. Conclusion It is suggested that T-cell mediate immune responses which may play a role in the etiopathology of postpartum depression. SJ Fang had an antidepressant effect on the immune system in rats with PPD. PMID:26203247

  4. Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2.

    PubMed

    Tang, Wen-Zhao; Wang, Ying-Ai; Gao, Tian-Yang; Wang, Xiao-Jing; Zhao, Yun-Xue

    2017-05-01

    The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2Cl2 extract of P. catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H2O2. Phytochemical results indicated that P. catalpifolia was a natural resource of abundant C-geranylated flavonoids. Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H2O2 and the C-geranyl substituent may be an important factor because of its lipophilic character. Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  5. Shen-Kang protects 5/6 nephrectomized rats against renal injury by reducing oxidative stress through the MAPK signaling pathways

    PubMed Central

    LIU, MEIYOU; PARK, JISOO; WU, XIAOXIAO; LI, YUWEN; TRAN, QUANGDON; MUN, KISUN; LEE, YONGJIN; HUR, GANG MIN; WEN, AIDONG; PARK, JONGSUN

    2015-01-01

    Chronic kidney disease (CKD) is a worldwide public health concern with limited treatment options. The incidence of CDK is increasing and the disease is associated with a poor quality of life and a high financial cost of treatment. Shen-Kang (SK), a traditional Chinese herbal medicine, has been used clinically in the treatment of renal diseases for decades. This study was carried out to validate the therapeutic effects of SK on renal injury induced by 5/6 nephrectomy, as well as its effects on the apoptosis of proximal tubule epithelial cells (HK-2 cells), in an aim to elucidate its mechanisms of action. For this purpose, an animal model of renal injury was created by subjecting rats to a 5/6 nephrectomy. The rats in the sham-operated and model groups received distilled water, while the rats in the SK and enalapril (EN) groups were treated with SK or EN. The levels of blood urea nitrogen (BUN) and serum creatinine (SCr) were measured. Kidney tissues obtained from the rats were stained with hematoxylin and eosin. HK-2 cells were employed to investigate the effects of SK on the apoptosis of renal proximal tubule epithelial cells induced by treatment with hydrogen peroxide (H2O2). In addition, cell viability was measured by MTT assay. Apoptotic events were monitored by western blot analysis, flow cytometric analysis and nuclear morphological anlaysis. The levels of intracellular reactive oxygen species (ROS) were measured by flow cytometric analysis with dihydroethidium staining. The results revealed that the administration of SK to 5/6 nephrectomized rats for 1 week significantly decreased the levels of SCr and BUN. The morphological observations of the kidneys also indicated the amelioration of damage to renal tissue. Treatment of the HK-2 cells with SK significantly protected the cells from H2O2-induced apoptosis, as indicated by an increase in cell viability, the decrease in the cleavage of poly(ADP-ribose) polymerase (PARP) and fewer condensed nuclei. H2O2-induced

  6. The effect of the intense laser field on the intersubband transitions in Ga 1- xIn xN yAs 1- y/GaAs single quantum well

    NASA Astrophysics Data System (ADS)

    Ungan, F.; Kasapoglu, E.; Duque, C. A.; Sari, H.; Sokmen, I.

    2011-11-01

    The effect of the intense laser field on the intersubband optical absorption for (1-2) transition in a Ga 1- xIn xN yAs 1- y/GaAs single quantum well for different nitrogen and indium concentrations is investigated. The numerical calculations are performed in the effective-mass approximation. We have found that the increase of the nitrogen and indium concentrations with intense laser field leads to important effects on the optical properties of a quantum well. The obtained results show that the desired energy range corresponding to the subbands may be tuned by changing the laser intensity and the nitrogen and indium concentrations. This tunability gives a possibility for near-infrared electro-absorption modulators and quantum well infrared detectors.

  7. Optical spectroscopy reveals transition of CuInS2/ZnS to CuxZn1-xInS2/ZnS:Cu alloyed quantum dots with resultant double-defect luminescence

    NASA Astrophysics Data System (ADS)

    Yan, Ruolin; Zhang, Wenxia; Wu, Wenhui; Dong, Xingmin; Wang, Qiqi; Fan, Jiyang

    2016-12-01

    The structure and luminescence mechanisms of the CuInS2 quantum dots (QDs) after epitaxial growth of ZnS shell are in debate. The light absorption/emission spectroscopy reveals that after ZnS shell growth the cation diffusion at the CuInS2/ZnS interface results in formation of the alloyed CuxZn1- xInS2/ZnS:Cu QDs. These core/shell QDs exhibit dual-color photoluminescence with abnormal blue shift with decreasing excitation photon energy. The results show that the green and orange emissions originate separately from defects in the core and the shell. The absorption tail of the ZnS QDs turns from Urbach to Halperin-Lax type after Cu doping.

  8. [The influence of ZHU Gong's Huo ren shu (A Book for Savings Life)in the Southern Song Dynasty and its Influence on the discipline of Cold Pathogenic Disease].

    PubMed

    Lu, Ming-Xin

    2012-11-01

    ZHU Gong's Huo ren shu (A Book for Saving Life) is a famous work in the history of research on Treatise on Cold Damage Diseases. It has great influence on the study of cold pathogenic disease, especially that of the Song dynasty. Many authors reedited or annotated this book to inherit and developed the idea of the Huo ren shu. Thus, a lot of new books, including annotations, revisions, citations, or discussions, appeared. WANG Su's Zeng shi nan yang huo ren shu (Amplified Annotated Huorenshu), for example, is one of them. Those compiled as rhymes or knacks include XU Shu-wei's Shang han bai zheng ge (The Rhymes of Hundred Kinds of Cold Damage Disease), LI Zhi-xian's Huo ren shu kuo (Introduction to Huorenshu), QIAN Wen-li's Shang han bai wen ge (Hundred Questions on Cold Damage Disease), YANG Shi-ying's Shang han lei shu huo ren zong kuo (A General Introduction to Huorenshu, a Classified Book of Cold Damage Disease), and TANG Yin-cai's Shang han jie huo lun (Essay to Answering Suspicions on Cold Damage Disease). Those cited or inherited the book include LI Cheng's Shang han yao zhi (Gist of Cold Damage Disease), GUO Yong's Shang han bu wang lun (Supplements to Cold Damage Disease), SUN Zhi-ning's Shang han jian yao shi shuo (Ten Simple Discourses on Cold Damage Disease), and CHEN Zi-ming's Guan jian da quan liang fang (A Complete Effective Formulary with my Own Opinions). Those differentiating the essentials of the Huorenshu including CHENG Jiong's Huo ren shu bian (Differentiation for Huorenshu), and LU Zu-chang's Ni jin huo ren can tong yu yi (An Elaboration on Huorenshu to be Presented). All the above books indicate the impact of the Huorenshu, and show its influence on later ages as well.

  9. Shen-Kang protects 5/6 nephrectomized rats against renal injury by reducing oxidative stress through the MAPK signaling pathways.

    PubMed

    Liu, Meiyou; Park, Jisoo; Wu, Xiaoxiao; Li, Yuwen; Tran, Quangdon; Mun, Kisun; Lee, Yongjin; Hur, Gang Min; Wen, Aidong; Park, Jongsun

    2015-10-01

    Chronic kidney disease (CKD) is a worldwide public health concern with limited treatment options. The incidence of CDK is increasing and the disease is associated with a poor quality of life and a high financial cost of treatment. Shen-Kang (SK), a traditional Chinese herbal medicine, has been used clinically in the treatment of renal diseases for decades. This study was carried out to validate the therapeutic effects of SK on renal injury induced by 5/6 nephrectomy, as well as its effects on the apoptosis of proximal tubule epithelial cells (HK-2 cells), in an aim to elucidate its mechanisms of action. For this purpose, an animal model of renal injury was created by subjecting rats to a 5/6 nephrectomy. The rats in the sham-operated and model groups received distilled water, while the rats in the SK and enalapril (EN) groups were treated with SK or EN. The levels of blood urea nitrogen (BUN) and serum creatinine (SCr) were measured. Kidney tissues obtained from the rats were stained with hematoxylin and eosin. HK-2 cells were employed to investigate the effects of SK on the apoptosis of renal proximal tubule epithelial cells induced by treatment with hydrogen peroxide (H2O2). In addition, cell viability was measured by MTT assay. Apoptotic events were monitored by western blot analysis, flow cytometric analysis and nuclear morphological anlaysis. The levels of intracellular reactive oxygen species (ROS) were measured by flow cytometric analysis with dihydroethidium staining. The results revealed that the administration of SK to 5/6 nephrectomized rats for 1 week significantly decreased the levels of SCr and BUN. The morphological observations of the kidneys also indicated the amelioration of damage to renal tissue. Treatment of the HK-2 cells with SK significantly protected the cells from H2O2-induced apoptosis, as indicated by an increase in cell viability, the decrease in the cleavage of poly(ADP-ribose) polymerase (PARP) and fewer condensed nuclei. H2O

  10. [Effects of Bushen Wenyang Huayu Recipe on Expressions of HIF-1α, PHD2, and VHL in Endometriosis Rats with Shen Yang Deficiency Blood Stasis Syndrome].

    PubMed

    Jia, Yun-bo; Du, Hui-lan; Gao, Xing; Bian, Wen-hui; Lin, Xiao-hua; Ban, Guang-guo; Tian, Qian-hua

    2015-10-01

    To observe the effect of Bushen Wenyang Huayu Recipe (BWHR) on hypoxia inducible factor-1α (HIF-1α), proline hydroxylase2 (PHD2), von Hippel Lindau disease (VHL) suppressor gene expressions in endometriosis (EM) rats with Shen yang deficiency blood stasis syndrome (SYDBSS), and to explore the pathogenesis of EM and the mechanism of BWHR for treating EM. Totally 50 SD rats were randomly divided into five groups, i.e., the blank control group, the sham-operation group, the model group, the Chinese medicine (CM) group, and the Western medicine (WM) group, 10 in each group. Rats in the blank control group and the sham-operation group were fed routinely. Rats in the rest 3 groups received 30-day "extended refrigerator freezing and ice water immersion" and combined with " autotransplantation" to establish EM rat model with SYDBSS. One Milliliter BWHR at 3.33 g/mL was administered to rats in the CM group by gastrogavage. Gestrinone at the daily dose of 0. 5 mg/kg was administered to rats in the WM group by gastrogavage. Equal volume of normal saline was administered to rats in the model group, the blank control group, and the sham-operation group. The size and morphology of ectopic foci in rats were observed after 4 weeks of medication. Expressions of serum CA125, plasma cyclic adenosine monophosphate (cAMP), and plasma cyclic guanosine monophosphate (cGMP) were detected by radioimmunoassay. Morphological changes of eutopic endometrium and ectopic tissue were observed under the optical microscope by HE staining. Protein expressions and contents of HIF-lα, PHD2, and VHL were detected by immunohistochemical SABC method and Western blot. mRNA expressions of HIF-1α, PHD2, and VHL were detected by RT-PCR. The ectopic foci grew significantly in the model group. Their volumes were obviously contracted after treated by CM and WM. Compared with the blank control group and the sham-operation group, serum CA125 and plasma cGMP obviously increased, cAMP obviously decreased (P < 0

  11. [Effects of different Chinese medicine therapeutic methods on the ventricular remodeling and the heart function in chronic heart failure rats of Shen-yang deficiency syndrome].

    PubMed

    Wang, Jing; Wu, Shi-Da; Chen, Shou-Chun

    2012-09-01

    To observe the effects of warming yang method, nourishing yin method, activating blood method, and the combined treatment method on the ventricular remodeling (VR) and the heart function of heart failure (HF) rats of Shen-yang deficiency syndrome (SYDS). The Sprague-Dawley (SD) HF rat model of SYDS was established by continuously intravenous dripping adriamycin after economizing bilateral thyroid tissues. Rats were then randomly divided into the model group (administered with normal saline at the daily dose of 6 mL/kg by gastrogavage), the warming yang group (administered with Wenyang Jianxinling Extractum at the daily dose of 6 mL/kg by gastrogavage), the activating blood group (administered with Ligusticum Wallichii and Salvia Miltiorrhiza Extractum at the daily dose of 6 mL/kg by gastrogavage), the nourishing yin group (administered with Radix Ophiopogonis and Rhizoma Anemarrhenae Extractum at the daily dose of 6 mL/kg by gastrogavage), and the combined treatment group (administered with Yin-Yang Supplementing Extractum at the daily dose of 6 mL/kg by gastrogavage), 10 in each group. Another 10 SD rats were taken as the normal control group. They ate food and drank water freely. All rats were intervened for four successive weeks. The left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), maximal rate of left ventricular pressure of development ( +dp/dtmax), and maximal rate of left ventricular pressure of decline (-dp/dtmax) were observed. The systolic blood pressure (SBP) and the diastolic blood pressure (DBP) were determined. The mean arterial pressure (MAP) was calculated. The heart rate (HR) was recorded. Then all rats were killed and their hearts were taken out to weigh the heart mass (HM), the left ventricular mass (LVM), the right ventricular mass (RVM). The heart mass index (HMI) and the left ventricular mass index (LVMI) were calculated. The mRNA expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor

  12. [Effect of Shen-Mai injection and aminophylline on diaphragmatic muscle cell apoptosis and related gene expression in rats with chronic hypoxia].

    PubMed

    Zhao, Li-min; Xiong, Sheng-dao; Niu, Ru-ji; Xu, Yong-jian; Zhang, Zhen-xiang

    2003-10-01

    To investigate the effect of Shen-Mai injection (SMI) and aminophylline on diaphragmatic muscle cell apoptosis and the Fas/FasL expression in chronic hypoxic rats. Seventy-five male Wistar rats were randomly divided into three equal groups, control group (A group), SMI group (B group) and aminophylline group (C group). Then each group was further divided into five subgroups of pre-hypoxia, hypoxia 1 w, 2 w, 3 w and 4 w groups (5 rats each). The concentration of oxygen was (10 +/- 3)%, 7 d/w, 8 h/d for all groups, but only B group and C group received SMI (2 ml/d) and aminophylline (10 mg/kg) respectively. Apoptosis and Fas/FasL expression of diaphragmatic muscle cells were examined by the streptavidin biotin-peroxidase complex (SABC) immunohistochemistry techniques and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay, and Dunnett-t test was employed to compare the effects of SMI and aminophylline. (1) Fas, FasL expression in normal diaphragmatic muscle cells was very low with a positive rate of (2.77 +/- 0.45)% and (2.32 +/- 0.61)%. After hypoxia, the positive rates increased with the time of hypoxia time. SMI showed an inhibition on diaphragmatic muscle cell Fas and FasL expression;after hypoxia 1 w, 2 w, 3 w and 4 w, Fas expression [(6.36 +/- 4.17)%, (9.77 +/- 4.12)%, (18.02 +/- 6.91)% and (21.09 +/- 8.09)%] and FasL expression [(5.32 +/- 6.16)%, (9.58 +/- 3.79)%, (12.01 +/- 8.71)%, (19.43 +/- 10.31)%] in B group were different from those in A group respectively (all P < 0.05). But aminophylline did not show such an effect, the expression of Fas [(10.87 +/- 3.62)%, (24.13 +/- 3.79)%, (35.39 +/- 9.02)%, (39.56 +/- 10.12)%] and FasL [(9.37 +/- 4.07)%, (20.16 +/- 4.88)%, (31.81 +/- 7.07)%, (35.51 +/- 9.13)%] were not significantly different from those in A group respectively (all P > 0.05). (2) Diaphragmatic muscle cell apoptosis was very low in normal rats with a rate of (0.93 +/- 0.29)%, which also increased after hypoxia

  13. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α.

    PubMed

    Zhao, Yichao; Xu, Longwei; Qiao, Zhiqing; Gao, Lingchen; Ding, Song; Ying, Xiaoying; Su, Yuanyuan; Lin, Nan; He, Ben; Pu, Jun

    2016-03-11

    Positive evidence from clinical trials has fueled growing acceptance of traditional Chinese medicine (TCM) for the treatment of cardiac diseases; however, little is known about the underlying mechanisms. Here, we investigated the nature and underlying mechanisms of the effects of YiXin-Shu (YXS), an antioxidant-enriched TCM formula, on myocardial ischemia/reperfusion (MI/R) injury. YXS pretreatment significantly reduced infarct size and improved viable myocardium metabolism and cardiac function in hypercholesterolemic mice. Mechanistically, YXS attenuated myocardial apoptosis by inhibiting the mitochondrial mediated apoptosis pathway (as reflected by inhibition of mitochondrial swelling, cytochrome c release and caspase-9 activity, and normalization of Bcl-2 and Bax levels) without altering the death receptor and endoplasmic reticulum-stress death pathways. Moreover, YXS reduced oxidative/nitrative stress (as reflected by decreased superoxide and nitrotyrosine content and normalized pro- and anti-oxidant enzyme levels). Interestingly, YXS upregulated endogenous nuclear receptors including LXRα, PPARα, PPARβ and ERα, and in-vivo knockdown of cardiac-specific LXRα significantly blunted the cardio-protective effects of YXS. Collectively, these data show that YXS is effective in mitigating MI/R injury by suppressing mitochondrial mediated apoptosis and oxidative stress and by upregulating LXRα, thereby providing a rationale for future clinical trials and clinical applications.

  14. Ultra-fast liquid chromatography with tandem mass spectrometry determination of eight bioactive components of Kai-Xin-San in rat plasma and its application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats.

    PubMed

    Wang, Xiaotong; Zhang, Yue; Niu, Huibin; Geng, Yajing; Wang, Bing; Yang, Xiaomei; Yan, Pengyu; Li, Qing; Bi, Kaishun

    2017-05-01

    A method of ultra-fast liquid chromatography with tandem mass spectrometry was developed and validated for the simultaneous quantitation of eight bioactive components, including polygalaxanthone III, sibiricaxanthone B, tenuifolin, sibiricose A5, sibiricose A6, tenuifoliside A, ginsenoside Re and ginsenoside Rb1 in rat plasma after oral administration of Kai-Xin-San. The plasma samples were extracted by liquid-liquid extraction using digoxin as an internal standard. Chromatographic separation was performed on a Venusil MP C18 column (100 mm × 2.1 mm, 3 μm) with methanol and 0.05% acetic acid in water as mobile phase. The tandem mass spectrometric detection was performed in the multiple reaction monitoring with turbo ion spray source in the negative ionization. Validation parameters were within acceptable ranges. The established method has been successfully applied to compare the pharmacokinetic profiles of the analytes between normal and Alzheimer's disease rats. The results indicated that there were significant differences in pharmacokinetic parameters of some components between two groups, which may be due to the mechanisms of Alzheimer's disease and pharmacological effects of the analytes. The pharmacokinetic research in the pathological state might provide more useful information to guide the clinical usage of herbal medicine. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Kai-xin-san, a chinese herbal decoction containing ginseng radix et rhizoma, polygalae radix, acori tatarinowii rhizoma, and poria, stimulates the expression and secretion of neurotrophic factors in cultured astrocytes.

    PubMed

    Zhu, Kevin Yue; Xu, Sherry Li; Choi, Roy Chi-Yan; Yan, Artemis Lu; Dong, Tina Ting-Xia; Tsim, Karl Wah-Keung

    2013-01-01

    Kai-xin-san (KXS), a Chinese herbal decoction prescribed by Sun Simiao in Beiji Qianjin Yaofang about 1400 years ago, contains Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria. In China, KXS has been used to treat stress-related psychiatric diseases with the symptoms of depression and forgetfulness. Although animal study has supported the antidepression function of KXS, the mechanism in cellular level is still unknown. Here, a chemically standardized water extract of KXS was applied onto cultured astrocytes in exploring the action mechanisms of KXS treatment, which significantly stimulated the expression and secretion of neurotrophic factors, including NGF, BDNF, and GDNF, in a dose-dependent manner: the stimulation was both in mRNA and protein levels. In addition, the water extracts of four individual herbs did not significantly stimulate the expression of neurotrophic factors, which could explain the optimized effect of KXS in a herbal decoction. The KXS-induced expression of neurotrophic factors did not depend on signaling mediated by estrogen receptor or protein kinase. The results suggested that the antidepressant-like action of KXS might be mediated by an increase of expression of neurotrophic factors in astrocytes, which fully supported the clinical usage of this decoction.

  16. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor α

    PubMed Central

    Zhao, Yichao; Xu, Longwei; Qiao, Zhiqing; Gao, Lingchen; Ding, Song; Ying, Xiaoying; Su, Yuanyuan; Lin, Nan; He, Ben; Pu, Jun

    2016-01-01

    Positive evidence from clinical trials has fueled growing acceptance of traditional Chinese medicine (TCM) for the treatment of cardiac diseases; however, little is known about the underlying mechanisms. Here, we investigated the nature and underlying mechanisms of the effects of YiXin-Shu (YXS), an antioxidant-enriched TCM formula, on myocardial ischemia/reperfusion (MI/R) injury. YXS pretreatment significantly reduced infarct size and improved viable myocardium metabolism and cardiac function in hypercholesterolemic mice. Mechanistically, YXS attenuated myocardial apoptosis by inhibiting the mitochondrial mediated apoptosis pathway (as reflected by inhibition of mitochondrial swelling, cytochrome c release and caspase-9 activity, and normalization of Bcl-2 and Bax levels) without altering the death receptor and endoplasmic reticulum-stress death pathways. Moreover, YXS reduced oxidative/nitrative stress (as reflected by decreased superoxide and nitrotyrosine content and normalized pro- and anti-oxidant enzyme levels). Interestingly, YXS upregulated endogenous nuclear receptors including LXRα, PPARα, PPARβ and ERα, and in-vivo knockdown of cardiac-specific LXRα significantly blunted the cardio-protective effects of YXS. Collectively, these data show that YXS is effective in mitigating MI/R injury by suppressing mitochondrial mediated apoptosis and oxidative stress and by upregulating LXRα, thereby providing a rationale for future clinical trials and clinical applications. PMID:26964694

  17. Kai-Xin-San, a Chinese Herbal Decoction Containing Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria, Stimulates the Expression and Secretion of Neurotrophic Factors in Cultured Astrocytes

    PubMed Central

    Zhu, Kevin Yue; Xu, Sherry Li; Choi, Roy Chi-Yan; Yan, Artemis Lu; Dong, Tina Ting-Xia; Tsim, Karl Wah-Keung

    2013-01-01

    Kai-xin-san (KXS), a Chinese herbal decoction prescribed by Sun Simiao in Beiji Qianjin Yaofang about 1400 years ago, contains Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria. In China, KXS has been used to treat stress-related psychiatric diseases with the symptoms of depression and forgetfulness. Although animal study has supported the antidepression function of KXS, the mechanism in cellular level is still unknown. Here, a chemically standardized water extract of KXS was applied onto cultured astrocytes in exploring the action mechanisms of KXS treatment, which significantly stimulated the expression and secretion of neurotrophic factors, including NGF, BDNF, and GDNF, in a dose-dependent manner: the stimulation was both in mRNA and protein levels. In addition, the water extracts of four individual herbs did not significantly stimulate the expression of neurotrophic factors, which could explain the optimized effect of KXS in a herbal decoction. The KXS-induced expression of neurotrophic factors did not depend on signaling mediated by estrogen receptor or protein kinase. The results suggested that the antidepressant-like action of KXS might be mediated by an increase of expression of neurotrophic factors in astrocytes, which fully supported the clinical usage of this decoction. PMID:24222781

  18. [Exploring the Correlation between Pi and Shen from the Excretion of AA-I and Expressions of Or- ganic Anion Transporting Polypeptide 2al and 2 b1 in Pi Deficiency Model Rats].

    PubMed

    Xiang, Ting; Ren, Bin; Yang, Zhang-bin; Sun, Bao-guo; Chen, Ze-xiong; Chen, Yan; Zhang, Shi-jun

    2015-10-01

    To explore the correlation between Pi and Shen by observing the relationship between the metabolism of aristolochic acid (AA) and mRNA and protein expression levels of organic anion transporting polypeptide (oatp) superfamily member 2a1 and 2 b1 (oatp2al and oatp2bl) in renal, small intestinal, and large intestinal tissues of Pi deficiency syndrome (PDS) model rats. Totally 46 Sprague-Dawley (SD) rats were randomly divided into four groups, i.e., the blank group (n = 12), the PDS group (n = 22), the AA-I group (n = 6), and the PDS AA-I group (n = 6). PDS model was established by subcutaneously injecting Reserpine at the daily dose of 5 mg/kg for 16 successive days. Carotid intubation was performed in 6 rats selected from the blank group and the PDS group. Pharmacokinetics of AA-I were detected at 5, 15, 30, 45, and 60 min after gastrogavage of AA-I. AA-I concentrations in renal, small intestinal, and large intestinal tissues of 10 rats selected from the PDS group were determined. Normal saline was administered to 6 rats selected from the PDS group and the blank group by gastrogavage. Renal, small intestinal, and large intestinal tissues were collected in the AA-I group and the PDS AA-I group at 60 min after gastrogavage of AA-I. mRNA and protein expression levels of oatp2a1 and oatp2b1 in each tissue were detected using real-time polymerase chain reaction (RT- PCR) and Western blot. Compared with the blank group, plasma concentrations of in vivo AA-I were obviously higher in the PDS group at 15, 30, 45, and 60 min after gastrogavage of AA-I with statistical difference (P < 0.05). Plasma concentrations of AA-I were obviously decreased at 60 min after gastrogavage of AA-I; AA-I concentrations in renal and large intestinal tissues were elevated; AA-I concentrations in small intestinal tissues were obviously reduced in the PDS group. There was no statistical difference in mRNA expression levels of oatp2a1 and oatp2b1 in the aforesaid three tissues of rats between the

  19. ac susceptibility measurements on toroid shaped samples of CdCr2xIn2 - 2xS4 (0.85 < x < 1) spinel solid solutions (abstract)

    NASA Astrophysics Data System (ADS)

    Saifi, A.; Cagan, V.; Dormann, J. L.; Nogues, M.

    1985-04-01

    At low temperature CdCr2xIn2-2xS4 spinel solid solutions show a ferromagnetic-spin-glass transition. In the present work the ac susceptibility measurements (130 Hz<ν<100 kHz) have been carried out on toroid-shaped samples, which allows us to minimize the macroscopic demagnetizing fields, by using a technique based on a direct flux determination. Our results are compared with previous measurements, performed by using standard methods. The shape of the χ'(ν) curves is similar to that obtained from the standard methods: no maximum in the transition temperature region (4 K

  20. First description of the male of Draconarius jiangyongensis (Peng et al., 1996) (Araneae, Agelenidae)

    PubMed Central

    Chen, Zhuoer; Yin, Haiqiang; Xu, Xiang

    2016-01-01

    Abstract The male of Draconarius jiangyongensis (Peng, Gong & Kim, 1996) is described for the first time from Xinning County, Hunan Province, China. Morphological descriptions and illustrations of both sexes of this species are given in this study. The placement of this species in Draconarius is doubted. PMID:27551186

  1. The Effect of ShenQi FuZheng Injection in Combination with Chemotherapy versus Chemotherapy Alone on the Improvement of Efficacy and Immune Function in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

    PubMed Central

    dedong, Cao; huilin, Xu; Anbing, He; Ximing, Xu; wei, Ge

    2016-01-01

    Objective To evaluate the effect of ShenQi FuZheng Injection (SFI) on cellular immunity and clinical efficacy in patients with advanced non small cell lung cancer(NSCLC) when combined with chemotherapy. Methods Electronic databases including EMBASE, PUBMED, the conference proceedings of the American Society of Clinical Oncology (ASCO), Cochrane, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biological Medical disc(CBM) were searched, until July, 2015. The randomized controlled clinical studies reporting results of efficacy and immune function were collected according to the inclusion criteria. Cochrane handbook 5.1.0 was applied to assess the quality of included trials and Revman 5 software was used for data analysis. Results Fifteen studies including 1006 cases of advanced NSCLC were included based on the inclusion criteria. The results of meta-analysis showed that there were significant differences in percentages of CD3+ cells (SMD = 13.48; 95%CI: 8.11–18.85; p<0.01), CD4+ cells (SMD = 10.78; 95%CI, 6.38–15.18; p<0.01), NK [WMD = 8.59, 95% CI(3.97, 13.21), p = 0.003], and ratio of CD4+/ CD8+ (SMD = 0.32; 95%: 0.28–0.36; p<0.01) between SFI combination group and control group, whereas the difference was not significant in CD8+ (SMD = -1.44; 95%CI, -4.53–1.65; p = 0.36). Funnel plot, Begg's rank correlation test and Egger's linear regression analysis indicated that there was significant publication bias across studies. Conclusion SFI is effective to improve the efficacy of chemotherpay and function of cellular immunity in NSCLC patients, however, high quality RCTs are needed to further confirm the findings. PMID:27015629

  2. Pharmacological investigation of a HPLC/MS standardized three herbal extracts containing formulae (Bu-Shen-Yi-Qi-Tang) on airway inflammation and hypothalamic-pituitary-adrenal axis activity in asthmatic mice.

    PubMed

    Luo, Q L; Nurahmat, M; Li, M H; Sun, J; Chen, M X; Liu, F; Wei, Y; Dong, J C

    2014-09-25

    Bu-Shen-Yi-Qi-Tang (BSYQT) which is prescribed on the basis of clinical experience is commonly used in clinic of traditional Chinese medicine (TCM) for asthma treatment. The components of BSYQT include Radix Astragali (RA), Herba Epimedii (HE) and Radix Rehmanniae (RR). The aim of this study was to screen extracts of BSYQT with best anti-inflammatory activity in asthmatic mice, and separate and identify the chemical compounds in them. Our results suggested that 60% ethanol extract of herbs (H60) and granules (G60) of BSYQT were the two extracts with best anti-inflammatory activity and effects of H60 were a little better than that of G60. High-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF-MS/MS) analysis of the major chemical compounds of H60 and G60 revealed that 56 and 42 peaks were identified separately in H60 and G60. Further analysis revealed that 38 compounds were identified shared by H60 and G60, and 18 compounds were only in H60. There were 25 compounds in HE, 6 compounds in RR and 7 compounds in RA in the 38 compounds shared by G60 and H60. These 38 chemical components were tentatively considered the material basis of the anti-inflammatory activity of G60 and H60. The differences in the amount of the 38 chemical components as well as the 18 chemical components only in H60 were tentatively considered responsible for the activity differences between H60 and G60. In conclusion, these results suggested that extracts of BSYQT had inhibitory effects on airway inflammation in asthmatic mice, and H60 and G60 demonstrated the best anti-inflammatory activity. The 38 chemical compounds shared by H60 and G60 were responsible for their anti-inflammatory activity in asthmatic mice, and the differences in chemical compounds contents and amounts between H60 and G60 were responsible for this activity differences. This work would provide support for further pharmacodynamic material basis

  3. New Wave-Ice Interaction Physics in WAVEWATCH III

    DTIC Science & Technology

    2014-08-01

    number of collaborators and associates: Hayley Shen and Xin Zhao (Clarkson U.); Fabrice Ardhuin (Ifremer); Pam Posey, Michael Phelps , Richard Allard...covered with broken ice. Oceanol,, 47, 334–343. Posey, P. G., E. J. Metzger, A. J. Wallcraft, R. H. Preller, O. M. Smedstad, and M.W. Phelps , 2010

  4. Tongxinluo (Tong xin luo or Tong-xin-luo) capsule for unstable angina pectoris.

    PubMed

    Wu, Taixiang; Harrison, R A; Chen, Xiaoyan; Ni, Juan; Zhou, Likun; Qiao, Jieqi; Wang, Qin; Wei, Jiafu; Xin, Duan; Zheng, Jie

    2006-10-18

    Tongxinluo capsule is a medicine consisting of traditional Chinese herbs and insects used for cardiovascular diseases in China and some other Asian countries. To date the evidence of its effect has not previously been subject to systematic review, making it difficult to derive robust conclusions about its actual benefits, and indeed, possible harms. To assess systematically the effects of tongxinluo capsule in people with unstable angina pectoris. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) on The Cochrane Library, Issue 4 2004, MEDLINE, EMBASE, Chinese Biomedical Database, China National Knowledge Infrastructure, Japana Centra Revuo Medicina (all 1995 to 2005). We also handsearched the relevant Chinese journals, checked with manufacturers and registers of ongoing studies. Randomised trials comparing either tongxinluo capsule only or standard treatment plus tongxinluo capsule with standard treatment or other anti-angina pectoris drugs, placebo or no intervention. Two authors identified relevant studies for the review independently and went on to abstract data, and assess trial quality. Authors of included studies were contacted to obtain further information as required. 18 short term follow-up trials involving 1413 people were included. The studies did not provide strong support of a benefit of tongxinluo for reducing the combined outcome of acute myocardial infarction, angioplasty (PTCA) coronary artery bypass graft (CABG) and sudden death or all-cause mortality (RR 0.42, 95% CI 0.07 to 2.59, P=0.35; RR 0.33, 95% CI 0.01to 7.78, P=0.49, respectively). Tongxinluo reduced the frequency of acute angina attacks (WMD -1.20, 95%CI -1.38 to -1.02, P<0.00001 and RR -2.36, 95%CI -2.53 to -2.18, P<0.00001, respectively), improved ECG (RR 1.31, 95% CI 1.08 to 1.57, P=0.005) and angina symptoms (RR 1.21, 95% CI 1.06 to 1.40; P=0.007). Tongxinluo in combination with routine angina therapy appears to reduce the risk of subsequent AMI, PTCA or CABG, angina attacks and severity, as well as improving symptoms and ischaemic changes on the electrocardiogram (ECG). Due to the methodological limitations of the studies, the evidence is insufficient to make any conclusive recommendations about the use of this treatment for patients presenting with unstable angina. Large high quality randomised controlled trials are warranted.

  5. A New Approach to Construct Pathway Connected Networks and Its Application in Dose Responsive Gene Expression Profiles of Rat Liver Regulated by 2,4DNT

    DTIC Science & Technology

    2010-12-01

    discovery and transcriptomic responses in Daphnia magna exposed to munitions constituents. Environ Sci Technol 2009, 43:4188-4193. 6. Gong P, Guan X...from different sources, enhances the chance of exposing novel insights in the search for disease drug targets and biomarkers. Our results provide...Chen JY, Yan Z, Shen C, Fitzpatrick DP, Wang M: A systems biology approach to the study of cisplatin drug resistance in ovarian cancers. J Bioinform

  6. Investigation on Qiong yao shen shu (Qiongyao's Magical Book).

    PubMed

    Huang, L

    1999-01-01

    Written in about the period of late Yuan to early Ming dynasties, Qiongyao's Magical Book is attributed to a Taoist who was also conversant with acupunture art. By investigation, it is found that there are, at least, three books carrying the same title of Qiongyao's Magical Book, including a 3 volume Qiongyao's Magical Book now lost; a 3 - volume Qiongyao's Magical Book of Discovery (also called The Acupuncture Classic of Qiongyao the Immortal printed in the Ming dynasty, which is entirely different from the previous one and is an apocrypha; and a 4 - volume Qiongyao's Magical Book printed in the Qing dynasty also called Qiongyao's Great Collections of Magical Books wiich is a mixture of authentic and apocryphal texts in which 2 medical books irrelevant to the original are attached to the end of volume 3, with supplements by later writers intermingled in other volumes.

  7. [Discussion on Tang edition (TE) and notes of the Tang edition (NT) under the "ink cap" in Zheng lei ben cao (Classified materia medica)].

    PubMed

    Shang, Zhijun

    2002-04-01

    The TE and NT cited under ink cap in Zheng lei ben cao (Classified Materia Medica) cannot be found in the contents and fragmentary volumes of Xin xiu ben cao (Newly Revised Materia Medica), yet can be seen in the "annotations of Shu ben cao (Materia Medica of Sichuan)", cited by Zhang Yuxi. This showed that the TE and NT were, in fact, coming from Shu ben cao, whose old name was Chong guang ying gong ben cao (Augmented Yinggong's Materia Medica). The so - called Yinggong was Li Ji, who compiled Tang ben cao (Materia Medica of the Tang Dynasty) by the imperial order, and gained the title Master Yingguogong, hence the title. Chong guang ying gong ben cao was meant revised Tang ben cao. This was the reason why Tang Shenwei called Shu ben cao as Tang ben cao right away in his Zheng lei ben cao.

  8. VizieR Online Data Catalog: Molecular clouds and star formation (Gong+, 2016)

    NASA Astrophysics Data System (ADS)

    Gong, Y.; Mao, R. Q.; Fang, M.; Zhang, S. B.; Su, Y.; Yang, J.; Jiang, Z. B.; Xu, Y.; Wang, M.; Wang, Y.; Lu, D. R.; Sun, J. X.

    2016-02-01

    We include three FITS files containing the data-cubes (position-position-velocity) of 12CO, 13CO, and C18O emission lines. We used the Galactic coordinates for the spatial dimensions and V_lsr for the spectral dimension. The pixel size is 30" in spatial dimension and the channel width is about 0.17km/s. All the intensities have been converted to a scale of main beam temperatures in units of K. (3 data files).

  9. Magnetoseismology of Active Regions using Multi-wavelength Observations from GONG and SDO

    NASA Astrophysics Data System (ADS)

    Tripathy, Sushanta; Jain, Kiran; Kholikov, Shukur; Hill, Frank; Cally, Paul

    2016-05-01

    The structure and dynamics of active regions beneath the surface show significant uncertainties due to our limited understanding of the wave interaction with magnetic field. Recent numerical simulations further demonstrate that the atmosphere above the photospheric levels also modifies the seismic observables at the surface. Thus the key to improve helioseismic interpretation beneath the active regions requires a synergy between models and helioseismic inferences from observations. In this context, using data from Global Oscillation Network Group and from Helioseismic Magnetic Imager and Atmospheric Imaging Assembly onboard Solar Dynamics Observatory, we characterize the spatio-temporal power distribution in and around active regions. Specifically, we focus on the power enhancements seen around active regions as a function of wave frequencies, strength, inclination of magnetic field and observation height as well as the relative phases of the observables and their cross-coherence functions. It is expected that these effects will help us to comprehend the interaction of acoustic waves with magnetic field in the solar photosphere.

  10. Shao Nian Gong--A Children's Palace: Ideas for Teaching About China.

    ERIC Educational Resources Information Center

    Shoresman, Michele; Gumport, Roberta

    Children throughout the world enjoy similar activities. By experiencing the same games, foods, and activities that Chinese children enjoy, children in the United States can learn about Chinese culture. A variety of experiences are suggested to encourage active learning and involvement on the part of students with the aim of incorporating the study…

  11. Tai Chi and Qi Gong for Health and Well-Being

    MedlinePlus Videos and Cool Tools

    ... Online Continuing Education Series Distinguished Lecture Series Integrated Medicine Research Lecture Series All Training Information News & Events ... features tai chi A practice in traditional Chinese medicine that uses a series of slow, gentle movements ...

  12. Meridional flow in the solar convection zone. I. Measurements from gong data

    SciTech Connect

    Kholikov, S.; Serebryanskiy, A.; Jackiewicz, J.

    2014-04-01

    Large-scale plasma flows in the Sun's convection zone likely play a major role in solar dynamics on decadal timescales. In particular, quantifying meridional motions is a critical ingredient for understanding the solar cycle and the transport of magnetic flux. Because the signal of such features can be quite small in deep solar layers and be buried in systematics or noise, the true meridional velocity profile has remained elusive. We perform time-distance helioseismology measurements on several years worth of Global Oscillation Network Group Doppler data. A spherical harmonic decomposition technique is applied to a subset of acoustic modes to measure travel-time differences to try to obtain signatures of meridional flows throughout the solar convection zone. Center-to-limb systematics are taken into account in an intuitive yet ad hoc manner. Travel-time differences near the surface that are consistent with a poleward flow in each hemisphere and are similar to previous work are measured. Additionally, measurements in deep layers near the base of the convection zone suggest a possible equatorward flow, as well as partial evidence of a sign change in the travel-time differences at mid-convection zone depths. This analysis on an independent data set using different measurement techniques strengthens recent conclusions that the convection zone may have multiple 'cells' of meridional flow. The results may challenge the common understanding of one large conveyor belt operating in the solar convection zone. Further work with helioseismic inversions and a careful study of systematic effects are needed before firm conclusions of these large-scale flow structures can be made.

  13. Heterologous Expression of Aspergillus Niger --beta--D-Xylosidase (XInD): Characterization on Lignocellulosic Substrates

    SciTech Connect

    Selig, M. J.; Knoshaug, E. P.; Decker, S. R.; Baker, J. O.; Himmel, M. E.; Adney, W. S.

    2008-01-01

    The gene encoding a glycosyl hydrolase family 3 xylan 1,4-beta-xylosidase, xlnD, was successfully cloned from Aspergillus niger strain ATCC 10864. The recombinant product was expressed in Aspergillus awamori, purified by column chromatography, and verified by matrix-assisted laser desorption ionization, tandem time of flight (MALDI-TOF/TOF) mass spectroscopy of tryptic digests. The T{sub max} was determined using differential scanning microcalorimetry (DSC) to be 78.2 C; the K{sub m} and k{sub cat} were found to be 255 {micro}M and 13.7 s{sup -1}, respectively, using {rho}NP-{Beta}-d-xylopyranoside as substrate. End-product inhibition by d-xylose was also verified and shown to be competitive; the K{sub i} for this inhibition was estimated to be 3.3 mM. XlnD was shown to efficiently hydrolyze small xylo-oligomers to monomeric xylose, making it a critical hydrolytic activity in cases where xylose is to be recovered from biomass conversion processes. In addition, the presence of the XlnD was shown to synergistically enhance the ability of an endoxylanase, XynA from Thermomyces lanuginosus, to convert xylan present in selected pretreated lignocellulosic substrates. Furthermore, the addition of the XynA/XlnD complex was effective in enhancing the ability of a simplified cellulase complex to convert glucan present in the substrates.

  14. Shen 4-marker miRNA panel for lung cancer — EDRN Public Portal

    Cancer.gov

    We initially validated expressions of a set of miRNAs in paired lung tumor tissues and plasma specimens from 28 stage I NSCLC patients by real-time quantitative reverse transcription PCR, and then evaluated diagnostic value of the plasma miRNAs in a cohort of 58 NSCLC patients and 29 healthy individuals. The altered miRNA expressions were reproducibly confirmed in the tumor tissues. The miRNAs were stably present and reliably measurable in plasma. A logistic regression model with the best prediction was defined on the basis of the four genes (miRNA-21, -126, -210, and 486-5p), yielding 86.22% sensitivity and 96.55% specificity in distinguishing NSCLC patients from the healthy controls. (Lab Invest. 2011 Apr;91(4):579-87, PMID: 21116241)

  15. VizieR Online Data Catalog: Uranian satellites in 1995/97 (Shen+, 2002)

    NASA Astrophysics Data System (ADS)

    Shen, K. X.; Qiao, R. C.; Harper, D.; Hadjifotinou, K. G.; Liu, J. R.

    2002-06-01

    In this paper, we publish measurements of 864 positions of the major satellites of Uranus made in 1995-1997 using CCD (1024"*1024") detectors attached to the 1.56-metre Astrometric Telescope at the Sheshan station near Shanghai. Analysis of the data as inter-satellite positions shows that the observations of Ariel, Umbriel, Titania and Mirand relative to Oberon have root-mean-square residuals of 0.03"-0.05", except for the innermost and faintest satellite Miranda, whose residuals exceeded 0.08" due to the proximity of Uranus. (2 data files).

  16. VizieR Online Data Catalog: SDSS-RM project: technical overview (Shen+, 2015)

    NASA Astrophysics Data System (ADS)

    Shen, Y.; Brandt, W. N.; Dawson, K. S.; Hall, P. B.; McGreer, I. D.; Anderson, S. F.; Chen, Y.; Denney, K. D.; Eftekharzadeh, S.; Fan, X.; Gao, Y.; Green, P. J.; Greene, J. E.; Ho, L. C.; Horne, K.; Jiang, L.; Kelly, B. C.; Kinemuchi, K.; Kochanek, C. S.; Paris, I.; Peters, C. M.; Peterson, B. M.; Petitjean, P.; Ponder, K.; Richards, G. T.; Schneider, D. P.; Seth, A.; Smith, R. N.; Strauss, M. A.; Tao, C.; Trump, J. R.; Wood-Vasey, W. M.; Zu, Y.; Eisenstein, D. J.; Pan, K.; Bizyaev, D.; Malanushenko, V.; Malanushenko, E.; Oravetz, D.

    2015-02-01

    Our reverberation mapping (RM) field is the Pan-STARRS 1 (PS1) Medium Deep Field (MDF) MD07 (RAJ2000=213.704, DEJ2000=+53.083), which is a 7deg2 field within the CFHT-LS W3 field. This field is fully covered in the SDSS-I/II and SDSS-III BOSS footprints. The final RM sample contains 849 quasars, each of which was assigned a fiber on the RM plates. The remaining fibers were allocated to calibration sources, including 70 spectrophotometric standard stars, 80 sky fibers, and 1 LRG target (enforced by the BOSS tiling algorithm, but actually not tiled on any existing object in SDSS imaging). The BOSS spectroscopic observations were acquired during 7 dark/gray runs from 2014 January 1 to 2014 July 3. The separation between epochs in a given run is roughly 3-4 days, but varies from run to run under different weather conditions. Typically five epochs were taken for each run when weather permitted, totaling 32 epochs. The main portion of the RM imaging of our program is obtained with the CFHT/MegaCam and the Steward Observatory Bok 2.3m/90Prime. Given that our RM sample covers a wide redshift range, the photometric monitoring is performed in the SDSS g band and i band to sample the quasar continuum at low and high redshifts, respectively. We also had six nights of KPNO-4m (Mayall)/MOSAIC-1.1 observation to perform multi-band (Ugriz) imaging of the RM field. (4 data files).

  17. VizieR Online Data Catalog: SDSS-RM project: velocity dispersions of QSOs (Shen+, 2015)

    NASA Astrophysics Data System (ADS)

    Shen, Y.; Greene, J. E.; Ho, L. C.; Brandt, W. N.; Denney, K. D.; Horne, K.; Jiang, L.; Kochanek, C. S.; McGreer, I. D.; Merloni, A.; Peterson, B. M.; Petitjean, P.; Schneider, D. P.; Schulze, A.; Strauss, M. A.; Tao, C.; Trump, J. R.; Pan, K.; Bizyaev, D.

    2015-09-01

    The spectra were taken as part of the SDSS-III BOSS survey (Eisenstein et al. 2011AJ....142...72E; Dawson et al. 2013AJ....145...10D) from 2014 January to July. The wavelength coverage of BOSS spectroscopy is 3650-10400Å, with a spectral resolution of R~2000. (2 data files).

  18. Salvia miltiorrhiza (Dan Shen) Significantly Ameliorates Colon Inflammation in Dextran Sulfate Sodium Induced Colitis

    PubMed Central

    Wen, Xiao-Dong; Wang, Chong-Zhi; Yu, Chunhao; Zhang, Zhiyu; Calway, Tyler; Wang, Yunwei; Li, Ping; Yuan, Chun-Su

    2014-01-01

    Inflammatory bowel disease increases the risks of human colorectal cancer. In this study, the effects of Salvia miltiorrhiza extract (SME) on chemically-induced colitis in a mouse model were evaluated. Chemical composition of SME was determined by HPLC analysis. A/J mice received a single injection of AOM 7.5 mg/kg. After one week, these mice received 2.5% DSS for 8 days, or DSS plus SME (25 or 50 mg/kg). DSS-induced colitis was scored with the disease activity index (DAI). Body weight and colon length were also measured. The severity of inflammatory lesions was further evaluated by colon tissue histological assessment. HPLC assay showed that the major constituents in the tested SME were danshensu, protocatechuic aldehyde, salvianolic acid D and salvianolic acid B. In the model group, the DAI score reached its highest level on Day 8, while the SME group on both doses showed a significantly reduced DAI score (both P < 0.01). As an objective index of the severity of inflammation, colon length was reduced significantly from the vehicle group to model group. Treatment with 25 and 50 mg/kg of SME inhibited the reduction of colon in a dose-related manner (P < 0.05 and P < 0.01, respectively). SME groups also significantly reduced weight reduction (P < 0.05). Colitis histological data supported the pharmacological observations. Thus, Salvia miltiorrhiza could be a promising candidate in preventing and treating colitis and in reducing the risks of inflammation-associated colorectal cancer. PMID:24117071

  19. The Comparison Study of gas source between two hydrate expeditions in ShenHu area, SCS

    NASA Astrophysics Data System (ADS)

    Cong, X. R.

    2016-12-01

    Two gas hydrate expeditions (GMGS 01&03) were conducted in the Pearl River Mouth Basin, SCS, which were organized by Guangzhou Marine Geological Survey in 2007 and 2015, respectively. Compared with the drilling results of "mixed bio-thermogenic gas and generally dominated by biogenic gas" in 2007, hydrocarbon component measurements revealed a higher content of ethane and propane in 2015 drilling, providing direct evidence that deep thermogenic gas was the source for shallow hydrate formation. According to the geochemical analyses of the results obtained from the industrial boreholes in Baiyun sag, the deep hydrocarbon gas obviously leaked from the reservoir as escape caused by Dongsha movement in the late Miocene, as a result thermogenic gas from Wenchang, Enping and Zhuhai hydrocarbon source rocks migrated to late Miocene shallow strata through faults, diapirs and gas chimney vertically migration. In this paper we report the differences in fluid migration channel types and discuss their effect in fluid vertical migration efficiency in the two Shenhu hydrate drilling areas. For the drilling area in 2007,when the limited deep thermogenic gas experienced long distance migration process from bottom to up along inefficient energy channel, the gas composition might have changed and the carbon isotope fractionation might have happened, which were reflected in the results of higher C1/C2 ratios and lighter carbon isotope in gas hydrate bearing sediments. As a result the gas is with more "biogenic gas" features. It means thermogenic gases in the deep to contributed the formation of shallow gas hydrate indirectly in 2007 Shenhu drill area. On another hand, the gases were transported to the shallow sediment layers efficiently, where gas hydrate formed, through faults and fractures from deep hydrocarbon reservoirs, and as the result they experienced less changes in both components and isotopes in 2015 drilling site.

  20. Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis.

    PubMed

    Wen, Xiao-Dong; Wang, Chong-Zhi; Yu, Chunhao; Zhang, Zhiyu; Calway, Tyler; Wang, Yunwei; Li, Ping; Yuan, Chun-Su

    2013-01-01

    Inflammatory bowel disease increases the risks of human colorectal cancer. In this study, the effects of Salvia miltiorrhiza extract (SME) on chemically-induced colitis in a mouse model were evaluated. Chemical composition of SME was determined by HPLC analysis. A/J mice received a single injection of AOM 7.5 mg/kg. After one week, these mice received 2.5% DSS for eight days, or DSS plus SME (25 or 50 mg/kg). DSS-induced colitis was scored with the disease activity index (DAI). Body weight and colon length were also measured. The severity of inflammatory lesions was further evaluated by colon tissue histological assessment. HPLC assay showed that the major constituents in the tested SME were danshensu, protocatechuic aldehyde, salvianolic acid D, and salvianolic acid B. In the model group, the DAI score reached its highest level on Day 8, while the SME group on both doses showed a significantly reduced DAI score (both p < 0.01). As an objective index of the severity of inflammation, colon length was significantly shorter in the model group than the vehicle group. Treatment with 25 and 50 mg/kg of SME inhibited the shortening of colon in a dose-related manner (p < 0.05 and p < 0.01, respectively). SME groups also significantly reduced weight reduction (p < 0.05). Colitis histological data supported the pharmacological observations. Thus, Salvia miltiorrhiza could be a promising candidate in preventing and treating colitis and in reducing the risks of inflammation-associated colorectal cancer.

  1. [Exploration of Yu Shen-chu's achievements in pharmacology and his academic idea].

    PubMed

    Hua, Bi-Chun

    2003-01-01

    Prof. Yu not only explored the origin of Chinese materia medica and its development, but also emphasized the education and popularization of Chinese, materia medica. He was arduous in practicing, summarizing, and writing of Chinese material medica and devoted all his life to the development and ducation of TCM. He was conversant with both TCM and Chinese pharmacology.

  2. A Comparison of Solar p-Mode Parameters from MDI and Gong: Mode Frequencies and Structure Inversions

    NASA Technical Reports Server (NTRS)

    Basu, S.; Christensen-Dalsgaard, J.; Howe, R.; Schou, J.; Thompson, M. J.; Hill, F.; Komm, R.

    2003-01-01

    Helioseismic analysis of solar global oscillations allows investigation of the internal structure of the Sun. One important test of the reliability of the inferences from helioseismology is that the results from independent sets of contemporaneous data are consistent with one another. Here we compare mode frequencies from the Global Oscillation Network Group and Michelson Doppler Imager on board SOHO and resulting inversion results on the Sun's internal structure. The average relative differences between the data sets are typically less than 1 x 10(exp -5) substantially smaller than the formal errors in the differences; however, in some cases the frequency differences show a systematic behavior that might nonetheless influence the inversion results. We find that the differences in frequencies are not a result of instrumental effects but are almost entirely related to the data pipeline software. Inversion of the frequencies shows that their differences do not result in any significant effects on the resulting inferences on solar structure. We have also experimented with fitting asymmetric profiles to the oscillation power spectra and find that, compared with the symmetric fits, this causes no significant change in the inversion results.

  3. A Comparison of Solar p-Mode Parameters from MDI and Gong: Mode Frequencies and Structure Inversions

    NASA Technical Reports Server (NTRS)

    Basu, S.; Christensen-Dalsgaard, J.; Howe, R.; Schou, J.; Thompson, M. J.; Hill, F.; Komm, R.

    2003-01-01

    Helioseismic analysis of solar global oscillations allows investigation of the internal structure of the Sun. One important test of the reliability of the inferences from helioseismology is that the results from independent sets of contemporaneous data are consistent with one another. Here we compare mode frequencies from the Global Oscillation Network Group and Michelson Doppler Imager on board SOHO and resulting inversion results on the Sun's internal structure. The average relative differences between the data sets are typically less than 1 x 10(exp -5) substantially smaller than the formal errors in the differences; however, in some cases the frequency differences show a systematic behavior that might nonetheless influence the inversion results. We find that the differences in frequencies are not a result of instrumental effects but are almost entirely related to the data pipeline software. Inversion of the frequencies shows that their differences do not result in any significant effects on the resulting inferences on solar structure. We have also experimented with fitting asymmetric profiles to the oscillation power spectra and find that, compared with the symmetric fits, this causes no significant change in the inversion results.

  4. Ultrastructural observations on sporogenesis of Myxobolus Kwangsiensis Hsieh, Gong & Xiao from the kidney of dace Labeo rohita

    NASA Astrophysics Data System (ADS)

    Xiao, Wu-Han; Xie, Xing-Ren; Gong, Xiao-Ning

    1996-09-01

    The early stages and capsulogenetic stages of sporogenesis of Myxobolus kwangsiensis were studied in detail by electron microscopy. M. kwangsiensis is an intracellular myxosporean infecting the epithelial cells of kidney tubules of young dace Labeo rohita. The M. kwangsiensis sporogensis presents the typical features of myxosporea. The initial stages are multinucleate primary cells, with one primary cell typically enclosing one secondary cell. The secondary cells are formed directly by cytokinesis inside the primary cells. The primary cell participates in the formation of the secondary cell nucleus. The nuclear division of primary cell is asynchronous by amitosis. The parasitic organisms may degenerate inside the epithelial cells at any stage. The modes of sporoblast formation, the typical features of myxosporea and the cause of its degradation are discussed.

  5. A resolution recognizing the continued persecution of Falun Gong practitioners in China on the 12th anniversary of the campaign by the Chinese Communist Party to suppress the Falun Gong movement, recognizing the Tuidang movement whereby Chinese citizens renounce their ties to the Chinese Communist Party and its affiliates, and calling for an immediate end to the campaign to persecute Falun Gong practitioners.

    THOMAS, 112th Congress

    Sen. Menendez, Robert [D-NJ

    2011-07-13

    07/13/2011 Referred to the Committee on Foreign Relations. (text of measure as introduced: CR S4561) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Real time flood forecasting in the Nan Basin, Thailand, by using a distributed Xin'anjiang Model

    NASA Astrophysics Data System (ADS)

    Chen, Xiaohong; Qiu, Xiaobin

    2015-04-01

    Taking Nan basin in Thailand as a research case, on the basis of DEM, this paper extracts the digital information of Nan basin and divides it into ten sub-basins, considering the land usage and terrain distribution, to construct the distributed Xinanjiang model. Before the model simulation, various digital basin information is established involving elevation matrix, river net matrix, direction matrix and so on. The three-water-source Xinanjiang model is adopted in the grids to calculate the runoff yield under a specific precipitation in grids, and then all the water flows of the grids are convoluted to the sub-basin's outlet to synthesize the runoff process of a subbasin. Eventually the subbasin runoff is routed to the basin outlet to obtain runoff process of the whole basin with real-time correction. The model parameters are calibrated by using the trial and error method. The sensitivity and uncertainty of the parameters are analyzed. The main achievements of this paper are as follows. (1) The basin information is extracted and the digital NAN basin is constructed on the basis of DEM data. As a result, a series of basin information matrix and digital Nan basin are generated. (2) The constant flow in grids and isochrones concept are used to replace the unit hydrograph of sub-basins. The basin discharge process is obtained through calculating the grid runoff yield and subbasin runoff convolution and routing the subbasin runoffs to the basin outlet. (3) The model is calibrated on more than 50 historical flood processes. The sensitivity and uncertainty of model parameters are analyzed by the perturbation analysis method, showing that some parameters, including KC, KKG, KKSS, WUM, KG, WLM, KSS and WDM are more sensitive. At the same time, the model uncertainty is analyed by the GLUE method and the results illustrate that the simulation effect depends on the values of parameter group while the observed runoff is in the uncertainty range. (4) The calculated discharge process is adaptively corrected by Attenuation memory least squares method to obtain final forecasting flood process. Verifications of this real-time flood forecasting model show high precision and the model system has been practically used in Thailand.

  7. Nuclear Structure in China 2010

    NASA Astrophysics Data System (ADS)

    Bai, Hong-Bo; Meng, Jie; Zhao, En-Guang; Zhou, Shan-Gui

    2011-08-01

    Personal view on nuclear physics research / Jie Meng -- High-spin level structures in [symbol]Zr / X. P. Cao ... [et al.] -- Constraining the symmetry energy from the neutron skin thickness of tin isotopes / Lie-Wen Chen ... [et al.] -- Wobbling rotation in atomic nuclei / Y. S. Chen and Zao-Chun Gao -- The mixing of scalar mesons and the possible nonstrange dibaryons / L. R. Dai ... [et al.] -- Net baryon productions and gluon saturation in the SPS, RHIC and LHC energy regions / Sheng-Qin Feng -- Production of heavy isotopes with collisions between two actinide nuclides / Z. Q. Feng ... [et al.] -- The projected configuration interaction method / Zao-Chun Gao and Yong-Shou Chen -- Applications of Nilsson mean-field plus extended pairing model to rare-earth nuclei / Xin Guan ... [et al.] -- Complex scaling method and the resonant states / Jian-You Guo ... [et al.] -- Probing the equation of state by deep sub-barrier fusion reactions / Hong-Jun Hao and Jun-Long Tian -- Doublet structure study in A[symbol]105 mass region / C. Y. He ... [et al.] -- Rotational bands in transfermium nuclei / X. T. He -- Shape coexistence and shape evolution [symbol]Yb / H. Hua ... [et al.] -- Multistep shell model method in the complex energy plane / R. J. Liotta -- The evolution of protoneutron stars with kaon condensate / Ang Li -- High spin structures in the [symbol]Lu nucleus / Li Cong-Bo ... [et al.] -- Nuclear stopping and equation of state / QingFeng Li and Ying Yuan -- Covariant description of the low-lying states in neutron-deficient Kr isotopes / Z. X. Li ... [et al.] -- Isospin corrections for superallowed [symbol] transitions / HaoZhao Liang ... [et al.] -- The positive-parity band structures in [symbol]Ag / C. Liu ... [et al.] -- New band structures in odd-odd [symbol]I and [symbol]I / Liu GongYe ... [et al.] -- The sd-pair shell model and interacting boson model / Yan-An Luo ... [et al.] -- Cross-section distributions of fragments in the calcium isotopes projectile

  8. VizieR Online Data Catalog: Transition rates on 2s2p3 configurations in N+ (Shen+, 2016)

    NASA Astrophysics Data System (ADS)

    Shen, X.; Liu, J.; Zhou, F.

    2016-07-01

    Wavefunctions were determined using the Multi-Configuration Dirac-Hartree-Fock (MCDHF) method. The core-core, core-valence, valence correlation, Breit interaction and quantum electrodynamics (QED) effects, as well as some higher order correlation effects, were considered to obtain accurate wavelengths (lambda), oscillator strengths (gf) and transition rates (A) of 2s22p2-2s2p3, 2s2p3-2s22pnl (n>=3) and 2s2p3-2s2p23s E1 transitions. (2 data files).

  9. Stability of transition waves and positive entire solutions of Fisher-KPP equations with time and space dependence

    NASA Astrophysics Data System (ADS)

    Shen, Wenxian

    2017-09-01

    This paper is concerned with the stability of transition waves and strictly positive entire solutions of random and nonlocal dispersal evolution equations of Fisher-KPP type with general time and space dependence, including time and space periodic or almost periodic dependence as special cases. We first show the existence, uniqueness, and stability of strictly positive entire solutions of such equations. Next, we show the stability of uniformly continuous transition waves connecting the unique strictly positive entire solution and the trivial solution zero and satisfying certain decay property at the end close to the trivial solution zero (if it exists). The existence of transition waves has been studied in Liang and Zhao (2010 J. Funct. Anal. 259 857-903), Nadin (2009 J. Math. Pures Appl. 92 232-62), Nolen et al (2005 Dyn. PDE 2 1-24), Nolen and Xin (2005 Discrete Contin. Dyn. Syst. 13 1217-34) and Weinberger (2002 J. Math. Biol. 45 511-48) for random dispersal Fisher-KPP equations with time and space periodic dependence, in Nadin and Rossi (2012 J. Math. Pures Appl. 98 633-53), Nadin and Rossi (2015 Anal. PDE 8 1351-77), Nadin and Rossi (2017 Arch. Ration. Mech. Anal. 223 1239-67), Shen (2010 Trans. Am. Math. Soc. 362 5125-68), Shen (2011 J. Dynam. Differ. Equ. 23 1-44), Shen (2011 J. Appl. Anal. Comput. 1 69-93), Tao et al (2014 Nonlinearity 27 2409-16) and Zlatoš (2012 J. Math. Pures Appl. 98 89-102) for random dispersal Fisher-KPP equations with quite general time and/or space dependence, and in Coville et al (2013 Ann. Inst. Henri Poincare 30 179-223), Rawal et al (2015 Discrete Contin. Dyn. Syst. 35 1609-40) and Shen and Zhang (2012 Comm. Appl. Nonlinear Anal. 19 73-101) for nonlocal dispersal Fisher-KPP equations with time and/or space periodic dependence. The stability result established in this paper implies that the transition waves obtained in many of the above mentioned papers are asymptotically stable for well-fitted perturbation. Up to the author

  10. Even Buddhist Monks Use a Gong: A Mindfulness Skills Programme for Young People Delivered through the "Mindful Gnats" Computer Game and App

    ERIC Educational Resources Information Center

    O'Reilly, Gary; Coyle, David; Tunney, Conall

    2016-01-01

    Mindful Gnats is a computer game and App that introduces mindfulness and relaxation skills to young people aged nine years and older. In this paper the authors describe their model for using technology to support children with the development of psychological skills. This model combines a computer game to introduce and practice psychological…

  11. Even Buddhist Monks Use a Gong: A Mindfulness Skills Programme for Young People Delivered through the "Mindful Gnats" Computer Game and App

    ERIC Educational Resources Information Center

    O'Reilly, Gary; Coyle, David; Tunney, Conall

    2016-01-01

    Mindful Gnats is a computer game and App that introduces mindfulness and relaxation skills to young people aged nine years and older. In this paper the authors describe their model for using technology to support children with the development of psychological skills. This model combines a computer game to introduce and practice psychological…

  12. SmAPf phase, its properties and potential dye alignment (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Korblova, Eva D.; Rochelle, Timothy; Guzman, Edward; Shao, Renfan; Maclennan, Joseph E.; Glaser, Matthew A.; Clark, Noel; Walba, David

    2016-09-01

    The first reported SmAPF phase, formed from the bent core mesogen W586, exhibits interesting and useful electrooptics.(1) Specifically, in teflon-aligned cells, upon application of an electric field, modulation of the birefringence is observed without rotation of the apparent optic axis. In addition, optical latching is observed, providing the long sought but never before seen "infinitely multistable" ferroelectric LC electrooptic switch. Based upon careful measurements of the cell behavior, the polar order parameter at temperatures just above the transition to a lower-lying smectic phase is close to unity. This suggested potential application of the phase as a host for controlled polar alignment of guest molecules. One clear application of the system is for electronic electrooptic modulation of light at telecommunications wavelengths (Kerr effect), which can be obtained in materials with polar orientation of visible dyes. Background and results of recent experiments in the host-guest chemistry of the W586 SmAPF phase, showing good orientation of designed NLO dyes, will be presented. (1) a) Reddy, R. A.; Zhu, C.; Shao, R.; Korblova, E.; Gong, T.; Shen, Y.; Garcia, E.; Glaser, M. A.; Maclennan, J. E.; Walba, D. M.; Clark, N. A. "Spontaneous ferroelectric order in a bent-core smectic liquid crystal of fluid orthorhombic layers," Science 2011, 332, 72-77. b) Korblova, E.; Walba, D.; Gong, T.; Reddy, A.; Zhu, C.; Shao, R.; Maclennan, J.; Glaser, M.; Clark, N. "Design and synthesis of an achiral ferroelectric smectic liquid crystal," Proc. SPIE 2011, 8114, (1), 81140X-1 - 81140X-9. (2) United States Patent: Walba US 9,187,500 B2, Nov. 17, 2015

  13. "The Cow Loves To Learn": The Hao-Xue-Xin Learning Model as a Reflection of the Cultural Relevance of "Zhima Jie," China's "Sesame Street."

    ERIC Educational Resources Information Center

    Li, Jin; Li, Jimei

    2002-01-01

    Examined the cultural basis and relevance of "Zhima Jie," a Chinese adaptation of "Sesame Street." Found that most of 3- to 6-year-olds in the sample desired books and learning materials, with disadvantaged children more likely than more advantaged children to desire books and learning materials. Older children showed a greater…

  14. Effects of indium doping on properties of xIn-0.1%Gd-TiO2 photocatalyst synthesized by sol-gel method

    NASA Astrophysics Data System (ADS)

    Zhang, Wenjie; Liu, Yuxuan; Pei, Xiaobei; Chen, Xijuan

    2017-05-01

    A sol-gel method was used to prepare a novel In-Gd co-doped TiO2 photocatalyst. The materials were characterized by XRD, SEM, FT-IR/FIR, UV-Vis diffuse reflectance, XPS, and N2 adsorption-desorption analyses. The diffraction patterns of all the materials belong to anatase phase TiO2 in tetragonal system. The doping of 0.1% Gd in the TiO2 metrix leads to a sharp reducing crystallite size, while the crystallite size decreases very slightly after the subsequent doping of indium. In3+ and Gd3+ ions are incorporated into the crystal lattice of anatase TiO2 by substituting Ti4+ ions. The main Ti-O bond is maintained in the TiO2 matrix and is not noticeable influenced by the dopants. Band gaps of the materials slightly decrease after doping. When indium content is less than 3%, both surface area and pore volume increase with rising indium content. The largest BET surface area of 122.7 m2/g is obtained in the 3%In-0.1%Gd-TiO2. The binding energies of titanium and oxygen in 0.1%Gd-TiO2 are nearly unchanged after doping of indium. The maximum photocatalytic activity is found on 3%In-0.1%Gd-TiO2. After 45 min of irradiation, more than 90% of methyl orange molecules are removed from the solution by 3%In-0.1%Gd-TiO2, while the efficiency is only 40% on the undoped TiO2.

  15. The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes

    PubMed Central

    Cao, Guolei; Wang, Xiaoli

    2016-01-01

    Objective. We investigated the expression levels of both FOSL2 mRNA and protein as well as evaluating DNA methylation in the blood of type 2 diabetes mellitus (T2DM) Uyghur patients from Xinjiang. This study also evaluated whether FOSL2 gene expression had demonstrated any associations with clinical and biochemical indicators of T2DM. Methods. One hundred Uyghur subjects where divided into two groups, T2DM and nonimpaired glucose tolerance (NGT) groups. DNA methylation of FOSL2 was also analyzed by MassARRAY Spectrometry and methylation data of individual units were generated by the EpiTyper v1.0.5 software. The expression levels of FOS-like antigen 2 (FOSL2) and the protein expression levels were analyzed. Results. Significant differences were observed in mRNA and protein levels when compared with the NGT group, while methylation rates of eight CpG units within the FOSL2 gene were higher in the T2DM group. Methylation of CpG sites was found to inversely correlate with expression of other markers. Conclusions. Results show that a correlation between mRNA, protein, and DNA methylation of FOSL2 gene exists among T2DM patients from Uyghur. FOSL2 protein and mRNA were downregulated and the DNA became hypermethylated, all of which may be involved in T2DM pathogenesis in this population. PMID:28050569

  16. "The Cow Loves To Learn": The Hao-Xue-Xin Learning Model as a Reflection of the Cultural Relevance of "Zhima Jie," China's "Sesame Street."

    ERIC Educational Resources Information Center

    Li, Jin; Li, Jimei

    2002-01-01

    Examined the cultural basis and relevance of "Zhima Jie," a Chinese adaptation of "Sesame Street." Found that most of 3- to 6-year-olds in the sample desired books and learning materials, with disadvantaged children more likely than more advantaged children to desire books and learning materials. Older children showed a greater…

  17. VizieR Online Data Catalog: Lag measurements for 15 z<0.8 QSOs from the SDSS-RM (Shen+, 2016)

    NASA Astrophysics Data System (ADS)

    Shen, Y.; Horne, K.; Grier, C. J.; Peterson, B. M.; Denney, K. D.; Trump, J. R.; Sun, M.; Brandt, W. N.; Kochanek, C. S.; Dawson, K. S.; Green, P. J.; Greene, J. E.; Hall, P. B.; Ho, L. C.; Jiang, L.; Kinemuchi, K.; McGreer, I. D.; Petitjean, P.; Richards, G. T.; Schneider, D. P.; Strauss, M. A.; Tao, C.; Wood-Vasey, W. M.; Zu, Y.; Pan, K.; Bizyaev, D.; Ge, J.; Oravetz, D.; Simmons, A.

    2016-04-01

    The spectroscopic data were taken during seven dark/gray runs from 2014 January to July and consist of a total of 32 epochs with an average cadence of ~4 days; each epoch had a typical exposure time of 2hr. The spectroscopic data were pipeline-processed as part of the SDSS-III Data Release 12 (Alam et al. 2015ApJS..219...12A). The wavelength coverage of BOSS spectroscopy is ~3650-10400Å, with a spectral resolution of R~2000. (2 data files).

  18. Traditional Chinese Medicine Induced Liver Injury

    PubMed Central

    2014-01-01

    Traditional Chinese Medicine (TCM) is popular around the world and encompasses many different practices with particular emphasis on herbal TCM. Using the PubMed database, a literature search was undertaken to assess the extent herbal TCM products exert rare hepatotoxicity. Analysis of reported cases revealed numerous specified herbal TCM products with potential hepatotoxicity. Among these were An Shu Ling, Bai Fang, Bai Xian Pi, Ban Tu Wan, Bo He, Bo Ye Qing Niu Dan, Bofu Tsu Sho San, Boh Gol Zhee, Cang Er Zi, Chai Hu, Chaso, Chi R Yun, Chuan Lian Zi, Ci Wu Jia, Da Chai Hu Tang, Da Huang, Du Huo, Gan Cao, Ge Gen, Ho Shou Wu, Hu Bohe You, Hu Zhang, Huang Qin, Huang Yao Zi, Hwang Geun Cho, Ji Gu Cao, Ji Ji, Ji Xue Cao, Jiguja, Jin Bu Huan, Jue Ming Zi, Kamishoyosan, Kudzu, Lei Gong Teng, Long Dan Xie Gan Tang, Lu Cha, Ma Huang, Mao Guo Tian Jie Cai, Onshido, Polygonum multiflorum, Qian Li Guang, Ren Shen, Sairei To, Shan Chi, Shen Min, Shi Can, Shi Liu Pi, Shou Wu Pian, Tian Hua Fen, White flood, Wu Bei Zi, Xi Shu, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, Zhen Chu Cao, and various unclassified Chinese herbal mixtures. Causality was firmly established for a number of herbal TCM products by a positive reexposure test result, the liver specific scale of CIOMS (Council for International Organizations of Medical Sciences), or both. Otherwise, the quality of case data was mixed, especially regarding analysis of the herb ingredients because of adulteration with synthetic drugs, contamination with heavy metals, and misidentification. In addition, non-herbal TCM elements derived from Agaricus blazei, Agkistrodon, Antelope, Bombyx, Carp, Fish gallbladder, Phellinus, Scolopendra, Scorpio, and Zaocys are also known or potential hepatotoxins. For some patients, the clinical course was severe, with risks for acute liver failure, liver transplantation requirement, and lethality. In conclusion, the use of few herbal TCM products may rarely be associated with hepatotoxicity in some

  19. The Effect of the Khong Wong Yai Parameters on Sounds by FEM

    NASA Astrophysics Data System (ADS)

    Bamrungwong, Joompon; Woraratsoontorn, Pattaraweerin

    2017-07-01

    The Khong Wong Yai is called Gong in English but different in number to tune the sounds, beeswax with not exactly amount is pasted under the bossed. It is a Thai’s percussion instrument usually involves some kind of striking on nipple gong. It is composed of 16 units of Gong as a circle of a rattan frame. The bossed or nipple gong embossed in center of a gong generates one key sound. Player has to percuss the gongs to create the rhythm with two hard rubber mallets or soft padded mallets as beaters and sits in the middle of the circle. The sound of the gong usually involves vibration of its own structure. The aim of this analysis is to study the eigen modes and find out the important parameters to generate sound frequency which are excited on the bossed or nipple gong by finite element analysis. In this paper the inertia relief method is to study the sound frequency of the Gong. The results show that the diameter of the Gong, the thickness of flange and the thickness of cylinder formed the Gong are important parameters which can be optimized to obtain the correct sound key.

  20. Quark Matter 2006 Organising and International Advisory Committees Quark Matter 2006 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2006-12-01

    Organising Committee Xiang-Zhou Cai (SINAP) Xu Cai (CCNU), Co-chair Zhan-Jun He (SINAP) TD Lee (Columbia University, CCAST), Honorary chair Ya-Hong Li Zuo-Tang Liang (Shandong University) Feng Liu (CCNU) Bo-Qiang Ma (Beijing University) Yu-Gang Ma (SINAP), Scientific secretary Ru-Keng Su (Fudan University) En-Ke Wang (CCNU), Scientific secretary Fan Wang (Nanjing University) Xiao-Lian Wang (USTC) Hu-Shan Xu (IMP) Wei-Qin Zhao (CCAST) Dai-Cui Zhou (CCNU) Shu-Hua Zhou (CIAE) Wei Zhou (SINAP) Zhi-Yuan Zhu (SINAP, CAS), Co-chair Peng-Fei Zhuang (Tsinghua University) Bing-Song Zou (IHEP) International Advisory Committee Jean Paul Blaizot, France Peter Braun Münzinger, Germany Igor M Dremin, Russia Christian Fabjan, Switzerland Jens Jorgen Gaardhoje, Denmark Hans-Ake Gustaffson, Sweden Hans Gutbrod, Germany Miklos Gyulassy, USA Timothy Hallman, USA Hideki Hamagaki, Japan John W Harris, USA Tetsuo Hatsuda, Japan Huan-Zhong Huang, USA Barbara Jacak, USA Peter Kevi, Hungary Thomas W Ludlam, USA Luciano Maiani, Italy Larry McLerran, USA Berndt Müller, USA Lodovico Riccati, Italy Hans Georg Ritter, USA Vesa Ruuskanen, Finland Jurgen Schukraft, Switzerland Wen-Qing Shen, China Edward V Shuryak, USA Bikash Sinha, India Johanna Stachel, Germany Horst Stöcker, Germany Itzhak Tserruya, Israel Xin-Nian Wang, USA Bolek Wyslouch, USA Fu-Jia Yang, China Glenn R Young, USA William A Zajc, USA Wen-Long Zhan, China Zong-Ye Zhang, China

  1. Effects of acupuncture treatment on depression insomnia: a study protocol of a multicenter randomized controlled trial

    PubMed Central

    2013-01-01

    Background More than 70% of patients with depression who see their doctors experience insomnia. Insomnia treatment is a very important link for depression treatment. Furthermore, antidepression treatment is also important for depression insomnia. In acupuncture, LU-7 (Lie Que) and KID-6 (Zhao Hai), which are two of the eight confluence points in meridian theory, are used as main points. An embedded needle technique is used, alternately, at two groups of points to consolidate the treatment effect. These two groups of points are BL-15 (Xin Shu) with BL-23 (Shen Shu) and BL-19 (Dan Shu) with N-HN-54 (An Mian). The effectiveness of these optimized acupuncture formulas is well proven in the practice by our senior acupuncturists in Guangdong Provincial Hospital of TCM. This study has been designed to examine whether this set of optimized clinical formulas is able to increase the clinical efficacy of depression insomnia treatment. Methods/design In this randomized controlled multicenter trial, all the eligible participants are diagnosed with depression insomnia. All participants are randomly assigned to one of two groups in a ratio of 1:1 and receive either conventional acupuncture treatment or optimized acupuncture treatment. Patients are evaluated using the Pittsburgh Sleep Quality Index(PSQI)and the Hamilton rating scale(HAMD) for depression. The use of antidepression and hypnotics drugs is also considered. Results are obtained at the start of treatment, 1 and 2 months after treatment has begun, and at the end of treatment. The entire duration of the study will be approximately 36 months. Discussion A high quality of trial methodologies is utilized in the study, and the results may provide better evidence for the effectiveness of acupuncture as a treatment for depression insomnia. The optimized acupuncture formula has potential benefits in increasing the efficacy of treating depression insomnia. Trial registration The trial was registered in Chinese Clinical Trial

  2. Effects of acupuncture treatment on depression insomnia: a study protocol of a multicenter randomized controlled trial.

    PubMed

    Chen, Yuan-Fang; Liu, Jian-Hua; Xu, Neng-Gui; Liang, Zhao-Hui; Xu, Zhen-Hua; Xu, Shu-Jun; Fu, Wen-Bin

    2013-01-03

    More than 70% of patients with depression who see their doctors experience insomnia. Insomnia treatment is a very important link for depression treatment. Furthermore, antidepression treatment is also important for depression insomnia. In acupuncture, LU-7 (Lie Que) and KID-6 (Zhao Hai), which are two of the eight confluence points in meridian theory, are used as main points. An embedded needle technique is used, alternately, at two groups of points to consolidate the treatment effect. These two groups of points are BL-15 (Xin Shu) with BL-23 (Shen Shu) and BL-19 (Dan Shu) with N-HN-54 (An Mian). The effectiveness of these optimized acupuncture formulas is well proven in the practice by our senior acupuncturists in Guangdong Provincial Hospital of TCM. This study has been designed to examine whether this set of optimized clinical formulas is able to increase the clinical efficacy of depression insomnia treatment. In this randomized controlled multicenter trial, all the eligible participants are diagnosed with depression insomnia. All participants are randomly assigned to one of two groups in a ratio of 1:1 and receive either conventional acupuncture treatment or optimized acupuncture treatment. Patients are evaluated using the Pittsburgh Sleep Quality Index(PSQI)and the Hamilton rating scale(HAMD) for depression. The use of antidepression and hypnotics drugs is also considered. Results are obtained at the start of treatment, 1 and 2 months after treatment has begun, and at the end of treatment. The entire duration of the study will be approximately 36 months. A high quality of trial methodologies is utilized in the study, and the results may provide better evidence for the effectiveness of acupuncture as a treatment for depression insomnia. The optimized acupuncture formula has potential benefits in increasing the efficacy of treating depression insomnia. The trial was registered in Chinese Clinical Trial Register (ChiCR-TRC-00000481) on 12 August 2009.

  3. Genetics Home Reference: tetrahydrobiopterin deficiency

    MedlinePlus

    ... Epub 2007 Dec 3. Citation on PubMed Liu TT, Chiang SH, Wu SJ, Hsiao KJ. Tetrahydrobiopterin-deficient ... Shen M, Zhou Z, Zhang Z, Shen S, Liu TT, Hsiao KJ. Long-term outcome and neuroradiological findings ...

  4. Complementary, Alternative, or Integrative Health: What's In a Name?

    MedlinePlus

    ... 2002. Other mind and body practices include acupuncture , relaxation techniques (such as breathing exercises, guided imagery, and progressive muscle relaxation), tai chi , qi gong , healing touch , hypnotherapy , and ...

  5. 33 CFR 86.23 - Construction.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Construction. 86.23 Section 86.23 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INLAND NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.23 Construction. Bells and gongs...

  6. 33 CFR 86.23 - Construction.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Construction. 86.23 Section 86.23 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INLAND NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.23 Construction. Bells and gongs...

  7. 33 CFR 86.23 - Construction.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Construction. 86.23 Section 86.23 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INLAND NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.23 Construction. Bells and gongs...

  8. 33 CFR 86.23 - Construction.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Construction. 86.23 Section 86.23 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INLAND NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.23 Construction. Bells and gongs...

  9. 33 CFR 86.23 - Construction.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Construction. 86.23 Section 86.23 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INLAND NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.23 Construction. Bells and gongs...

  10. 33 CFR 86.21 - Intensity of signal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Intensity of signal. 86.21... NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.21 Intensity of signal. A bell or gong, or other device having similar sound characteristics shall produce a sound...

  11. 33 CFR 86.21 - Intensity of signal.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Intensity of signal. 86.21... NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.21 Intensity of signal. A bell or gong, or other device having similar sound characteristics shall produce a sound...

  12. 33 CFR 86.21 - Intensity of signal.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Intensity of signal. 86.21... NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.21 Intensity of signal. A bell or gong, or other device having similar sound characteristics shall produce a sound...

  13. 33 CFR 86.21 - Intensity of signal.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Intensity of signal. 86.21... NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.21 Intensity of signal. A bell or gong, or other device having similar sound characteristics shall produce a sound...

  14. 33 CFR 86.21 - Intensity of signal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Intensity of signal. 86.21... NAVIGATION RULES ANNEX III: TECHNICAL DETAILS OF SOUND SIGNAL APPLIANCES Bell or Gong § 86.21 Intensity of signal. A bell or gong, or other device having similar sound characteristics shall produce a sound...

  15. Robotics Research for Cybersecurity

    DTIC Science & Technology

    2012-01-24

    Wei-Min Shen 1/24/12 Page 1 of 3 Robotics Research for Cybersecurity Wei-Min Shen Polymorphic Robotics Laboratory USC/ISI, 4676 Admiralty Way...Marina del Rey, CA 90292 Phone: 310-448-8710, Fax: 310-822-0751 Email: shen@isi.edu, Web: http://www.isi.edu/ robots / Executive Summary This...project is to conduct a comprehensive study of robotics research in the context of cybersecurity. Specifically, 1) Create a realistic cybersecurity test

  16. Mechanics of Multifunctional Materials and Microsystems

    DTIC Science & Technology

    2013-03-07

    Hart (U Mich)^ Aaron Dollar (Yale U)^ Xin Zhang (Boston U) C. T. Sun (Purdue U) Olivier Mondain-Monval (CNRS) Thomas Siegmund (Purdue U) Anna...Xin Zhang (Boston U) C. T. Sun (Purdue U) Olivier Mondain-Monval (CNRS) Thomas Siegmund (Purdue U) Anna Balazs (U Pitt) Nicole Zacharia (Texas A&M

  17. News in Brief

    NASA Astrophysics Data System (ADS)

    2012-12-01

    Vice President Shen Wenqing Meets with Ecuadorian Guests For the First Time a Chinese Researcher Gives the Plenary Lecture at the International Symposium on Combustion Vice President Shen Wenqing Meets with NSERC Executive Vice-President Vice President Sun Jiaguang Meets with CONICYT President Ten-Year Anniversary Workshop of NSFC-IIASA Young Scientists Summer Program Held in Beijing Vice President Shen Wenqing Meets Guest from K.T. Li Foundation The 6th ASIAHORCs General Meeting in Beijing President Chen Yiyu Meets with DFG Delegation Vice President Shen Yan Visited International Organizations in Italy and France Vice President Wang Jie Meets with CEO of Academy of Malaysia

  18. Full-Wave Tomographic and Moment Tensor Inversion Based on 3D Multigrid Strain Green’s Tensor Databases

    DTIC Science & Technology

    2014-04-30

    105. Shen, Y., et al., 2013, Construction of a nested, global empirical Green’s tensor database, Seismological Society of America meeting, Salt...W. Zhang, 2010, Full-wave ambient noise tomography of the northern Cascadia, SSA meeting (abstract), Seismological Research Letters, 81, 300. Shen

  19. Comprehensive Reproductive System Care Program - Clinical Breast Care Project (CRSCP-CBCP)

    DTIC Science & Technology

    2008-10-01

    Publication date: July 2008) Hong-Wen Deng, Hui Shen, Yongjun Liu, and Hai Hu (Editors). Current Topics in Human Genetics: Studies of Complex Diseases...In: Hong-Wen Deng, Hui Shen, Yongjun Liu, and Hai Hu (Editors). Current Topics in Human Genetics: Studies of Complex Diseases. World Scientific

  20. [Discussion on thoughts and methods for treatment of diabetic nephropathy by TCM according to inflammatory pathogenesis].

    PubMed

    Piao, Chun-Li; Nan, Hong-Mei; Jiang, Zhe

    2005-04-01

    Aim of this article was to investigate relationship between inflammatory pathogenesis of diabetic nephropathy and the TCM pathogenetic theory of Shen-Collateral impaired by Toxin, and to illustrate the method for removing toxin, activating collateral and protecting Shen can be an effective treatment for inhibiting the inflammatory pathogenesis of diabetic nephropathy.

  1. The Effect of Radical-Based Grouping in Character Learning in Chinese as a Foreign Language

    ERIC Educational Resources Information Center

    Xu, Yi; Chang, Li-Yun; Perfetti, Charles A.

    2014-01-01

    The logographic nature of the Chinese writing system creates a huge hurdle for Chinese as a foreign language (CFL) learners. Existing literature (e.g., Shen, [Shen, H. H., 2010]; Taft & Chung, [Taft, M., 1999]) suggests that radical knowledge facilitates character learning. In this project, we selected 48 compound characters in eight radical…

  2. The Effect of Radical-Based Grouping in Character Learning in Chinese as a Foreign Language

    ERIC Educational Resources Information Center

    Xu, Yi; Chang, Li-Yun; Perfetti, Charles A.

    2014-01-01

    The logographic nature of the Chinese writing system creates a huge hurdle for Chinese as a foreign language (CFL) learners. Existing literature (e.g., Shen, [Shen, H. H., 2010]; Taft & Chung, [Taft, M., 1999]) suggests that radical knowledge facilitates character learning. In this project, we selected 48 compound characters in eight radical…

  3. Development of a Highly Efficient and Accurate Wind-Wave Simulation Framework for Operational Data Assimilation

    DTIC Science & Technology

    2011-09-30

    undulatory boundaries. Part I: Basic solver,” J. Comput. Phys. 230, 5488-5509. Yang, D. & Shen, L. 2011b “Simulation of viscous flows with... undulatory boundaries. Part II: Coupling with other solvers for two-fluid computations,” J. Comput. Phys. 230, 5510-5531. Yang, D., Meneveau, C. & Shen

  4. Development of a Highly Efficient and Accurate Wind-Wave Simulation Framework for Operational Data Assimilation

    DTIC Science & Technology

    2012-09-30

    Yang, D. & Shen, L. 2011a “Simulation of viscous flows with undulatory boundaries. Part I: Basic solver,” J. Comput. Phys. 230, 5488-5509. Yang, D...Shen, L. 2011b “Simulation of viscous flows with undulatory boundaries. Part II: Coupling with other solvers for two-fluid computations,” J

  5. Accuracy Sampling Design Bias on Coarse Spatial Resolution Land Cover Data in the Great Lakes Region (United States and Canada)

    EPA Science Inventory

    A number of articles have investigated the impact of sampling design on remotely sensed landcover accuracy estimates. Gong and Howarth (1990) found significant differences for Kappa accuracy values when comparing purepixel sampling, stratified random sampling, and stratified sys...

  6. Big Ben on a Shoestring.

    ERIC Educational Resources Information Center

    Kalotas, T. M.; Lee, A. R.

    1993-01-01

    This article describes a demonstration in which a straightened coathanger supported by threads and held near the ears resembles bells or gongs when struck. A mathematical explanation of the effect is provided. (MVL)

  7. Big Ben on a Shoestring.

    ERIC Educational Resources Information Center

    Kalotas, T. M.; Lee, A. R.

    1993-01-01

    This article describes a demonstration in which a straightened coathanger supported by threads and held near the ears resembles bells or gongs when struck. A mathematical explanation of the effect is provided. (MVL)

  8. Mind and Body Practices for Fibromyalgia: What the Science Says

    MedlinePlus

    ... gong, and yoga resulted in modest improvements in sleep disturbances, fatigue, depressed mood, and health-related quality of ... investigators also found evidence of continued improvement in sleep disturbances and health-related quality of life 3 to ...

  9. Time to Talk: 6 Things to Know about Mind and Body Practices for Fibromyalgia

    MedlinePlus

    ... training, cognitive behavioral therapy, movement/body awareness practices, massage, acupuncture, and balneotherapy (hydrotherapy). Here are 6 things ... practices such as tai chi, qi gong, yoga, massage therapy, acupuncture, and balneotherapy may help relieve some ...

  10. Accuracy Sampling Design Bias on Coarse Spatial Resolution Land Cover Data in the Great Lakes Region (United States and Canada)

    EPA Science Inventory

    A number of articles have investigated the impact of sampling design on remotely sensed landcover accuracy estimates. Gong and Howarth (1990) found significant differences for Kappa accuracy values when comparing purepixel sampling, stratified random sampling, and stratified sys...

  11. Feature Detection for Model Assessment in State Estimation

    DTIC Science & Technology

    1991-10-15

    Gong Combat Control Systems Department S. C. Nardone University of Massachusetts Dartmouth DTICS ELECTE JUL 141992 DlNA Naval Underwater Systems...Assessment in State Estimation .AUTHOR(S) D. J. Ferkinhoff S. C. Nardone * J. G. Baylog K. F. Gong 7. PERFORLMING ORGANIZATION NAME(S) AND ADORESS(ES...VA 22203 11. SUPPLEMENTARY NOTES *S. C. Nardone is affiliated with the University of Massachusetts Dartmouth, North Dartmouth, MA 02747. 12

  12. The Chance-Constrained Critical Path for a Large Class of Distributions

    DTIC Science & Technology

    1988-04-01

    Ln 0 CCS Research Report 591 CO THE CHANCE-CONSTRAINED CRITICAL PATH 0) FOR A LARGE CLASS OF DISTRIBUTIONS by A. Chames L. Gong $I CENTER FOR...THE CHANCE-CONSTRAINED CRITICAL PATH FOR A LARGE CLASS OF DISTRIBUTIONS by A. Chames L. Gong March, 1988 a) The research for this paper was partly...FOR CYBERNETIC STUDIES LT IC A. Chames , Director JL E 1988 College of Business Administration, 5.202 The University of Texas at Austin Austin, Texas

  13. Assessing China’s Hegemonic Ambitions

    DTIC Science & Technology

    2007-11-02

    the Huang Shi Gong San Lue, and the Tang Tai Zong Li Wen Gong Wen Dui, collectively dating from the fifth century B.C. to about the tenth century...the heartland was not fully established until after the migratory stages in the Tang , Song, and Ming Dynasties, where the remaining parts of...chu shi ji ren sheng zhe xue. San jun yue kan no. 163. Taipei. Brehms, Denise. 2001. Observers Debate China’s Economy: Market or Controlled? MIT

  14. Ancient Chinese Precedents in Chinas National Defense.

    DTIC Science & Technology

    2007-11-02

    period and eventually lead into the Tang Dynasty around 700 AD. ’Ralph D. Sawyer, trans. The Seven Military Classics of Ancient China (Boulder...between emperor Tang Tai Zong of the Tang Dynasty and his chief military advisor Li Wei Gong, but there is debate about the work’s authenticity. While... Tang Tai Zong and Li Wei Gong lived 95 during the early Tang Dynasty , some historians claim the work is a forgery that was constructed in the late

  15. A Numerical Scheme for Predicting Transient Shock, Boundary Layer, and Magnetohydrodynamic Phenomenia

    DTIC Science & Technology

    1978-12-01

    33-35) studied the interaction of a conducting, viscous fluid with an applied magnetic field. It was found that the drag, skin friction and heat...R4=15D Rl=(Xl-YHIN).R3/(YHAX-YHIN)+R4 I1=R1 50 RETURN END SUBROUTINE TRUN (XIN, YOUT ) C C C...77-1 05 YOUT =O. IF (XIN.EO.O.) RETURN J=l Y=RBS(XIN) IF (Y.GT.1.) J=-l 1=0 10 1=1+1 IF (I. GT. 50) RETURN JI=/ittJ Y1=YJJt10. JJtJJtJI IF (J.EO

  16. A Summary of Proceedings and Participant Recommendations from a National Workshop on Institutionalizing Progress in Agricultural Extension and Education in Taiwan (Taichung, Taiwan, April 22-24, 1991) = Cejin Wo Guo Nongye Tuiguang Jiaoyu Xin Tizhi Yantaohui Zhuanji. Zhonghua Minguao Bashi Nian Siyue 22 zhi 24.

    ERIC Educational Resources Information Center

    Ministry of Education, Taipei (Taiwan).

    These proceedings contain four presentations from a workshop at which leaders in agriculture and education contributed suggestions for developing policies and plans for the new Agricultural Extension Education Graduate Institute (AEEGI) in Taiwan. Introductory materials include a list of members of the planning committee, workshop rationale,…

  17. Commentary on: "An integrated metabolic atlas of clear cell renal cell carcinoma." Hakimi AA, Reznik E, Lee CH, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P, Chen YB, Tickoo SK, Reuter VE, Cheng EH, Sander C, Hsieh JJ.: Cancer Cell. 2016 Jan 11;29(1):104-16.

    PubMed

    Lee, Byron H

    2017-09-01

    Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism, and antioxidant response. Tumor progression and metastasis were associated with metabolite increases in glutathione and cysteine/methionine metabolism pathways. We develop an analytic pipeline and visualization tool (metabolograms) to bridge the gap between TCGA transcriptomic profiling and our metabolomic data, which enables us to assemble an integrated pathway-level metabolic atlas and to demonstrate discordance between transcriptome and metabolome. Lastly, expression profiling was performed on a high-glutathione cluster, which corresponds to a poor-survival subgroup in the ccRCC TCGA cohort. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. PREFACE: 12th International Symposium on Multiscale, Multifunctional and Functionally Graded Materials (FGM 2012)

    NASA Astrophysics Data System (ADS)

    Zhou, Zhangjian; Li, Jingfeng; Zhang, Lianmeng; Ge, Changchun

    2013-03-01

    Seiichi Uemura, Japan Local Organizing Committee Professor Changchun Ge (Chairman) Professor Xuanhui Qu Professor Jingfeng Li Professor Wei Pan Professor Lianmeng Zhang; Professor Qingjie Zhang Professor Qiang Shen Professor Jianghong Gong Dr Xianhui Li Dr Min Xia

  19. Flavobacterium suzhouense sp. nov., isolated from farmland river sludge.

    PubMed

    Zhang, Hao; Cheng, Ming-Gen; Sun, Bin; Guo, Su-Hui; Song, Man; Li, Qiang; Huang, Xing

    2015-02-01

    A Gram-stain-negative bacterium, designated XIN-1(T), was isolated from a farmland river sludge sample in Suzhou, China. Cells of strain XIN-1(T) were strictly aerobic, non-motile and rod-shaped. Strain XIN-1(T) grew optimally at pH 7.0 and 28 °C. Phylogenetic analysis of the 16S rRNA gene sequences showed that strain XIN-1(T) was most closely related to Flavobacterium hauense BX12(T) (98.2 % sequence similarity), followed by Flavobacterium beibuense F44-8(T) (96.3 %). The major respiratory quinone was menaquinone-6 and the major polar lipid was phosphatidylethanolamine. The major fatty acids (>5 %) were summed feature 3 (comprising C16 : 1ω7c and/or C16 : 1ω6c), summed feature 4 (comprising iso-C17 : 1 I and/or anteiso-C17 : 1 B), iso-C15 : 0, C16 : 0 and iso-C17 : 0 3-OH. The genomic DNA G+C content of strain XIN-1(T) was 39.8 mol%. Strain XIN-1(T) showed low DNA-DNA relatedness with F. hauense BX12(T) (38.7±0.5 %). On the basis of genotypic and phenotypic data, strain XIN-1(T) is considered to represent a novel species of the genus Flavobacterium, for which the name Flavobacterium suzhouense sp. nov. is proposed. The type strain is XIN-1(T) ( = CCTCC AB 2014200(T) = KCTC 42107(T)).

  20. Genomes to Life Project Quartely Report October 2004.

    SciTech Connect

    Heffelfinger, Grant S.; Martino, Anthony; Rintoul, Mark Daniel; Geist, Al; Gorin, Andrey; Xu, Ying; Palenik, Brian

    2005-02-01

    .genomes-to-life.org Acknowledgment We want to gratefully acknowledge the contributions of the GTL Project Team as follows: Grant S. Heffelfinger1*, Anthony Martino2, Andrey Gorin3, Ying Xu10,3, Mark D. Rintoul1, Al Geist3, Matthew Ennis1, Hashimi Al-Hashimi8, Nikita Arnold3, Andrei Borziak3, Bianca Brahamsha6, Andrea Belgrano12, Praveen Chandramohan3, Xin Chen9, Pan Chongle3, Paul Crozier1, PguongAn Dam10, George S. Davidson1, Robert Day3, Jean Loup Faulon2, Damian Gessler12, Arlene Gonzalez2, David Haaland1, William Hart1, Victor Havin3, Tao Jiang9, Howland Jones1, David Jung3, Ramya Krishnamurthy3, Yooli Light2, Shawn Martin1, Rajesh Munavalli3, Vijaya Natarajan3, Victor Olman10, Frank Olken4, Brian Palenik6, Byung Park3, Steven Plimpton1, Diana Roe2, Nagiza Samatova3, Arie Shoshani4, Michael Sinclair1, Alex Slepoy1, Shawn Stevens8, Chris Stork1, Charlie Strauss5, Zhengchang Su10, Edward Thomas1, Jerilyn A. Timlin1, Xiufeng Wan11, HongWei Wu10, Dong Xu11, Gong-Xin Yu3, Grover Yip8, Zhaoduo Zhang2, Erik Zuiderweg8 *Author to whom correspondence should be addressed (gsheffe%40sandia.gov) 1. Sandia National Laboratories, Albuquerque, NM 2. Sandia National Laboratories, Livermore, CA 3. Oak Ridge National Laboratory, Oak Ridge, TN 4. Lawrence Berkeley National Laboratory, Berkeley, CA 5. Los Alamos National Laboratory, Los Alamos, NM 6. University of California, San Diego 7. University of Illinois, Urbana/Champaign 8. University of Michigan, Ann Arbor 9. University of California, Riverside 10. University of Georgia, Athens 11. University of Missouri, Columbia 12. National Center for Genome Resources, Santa Fe, NM Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

  1. The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE).

    PubMed

    Nair, Rajesh; Sellaturay, Senthy; Sriprasad, Seshadri

    2012-01-01

    Emperor Shen-Nung was the second of China's mythical emperors (3500-2600 BCE). Widely considered the father of Chinese medicine, he catalogued over 365 species of medicinal plants which he personally tasted. Through his treatise 'Shen Nung Benchau Jing', we relive Emperor Shen-Nung's contribution to urology with reference to his management of erectile dysfunction. Time-related sources in medical and historical literature were reviewed, including the 'Shen Nung Benchau Jing' (The medicine book of Emperor Shen-Nung), archives and manuscripts at the Wellcome History of Medicine Collection, the Royal Society of Medicine, London, The Hong Kong Museum of Medical Sciences, and The Museum of Medical History, Shanghai, China. Chinese traditional herbal medicine began approximately 5000 years ago. Agricultural clan leader, Emperor Shen-Nung, was said to have a 'crystal-like belly' to watch the reactions in his own stomach of the herbs he collected. Ginseng was among of Shen Nung's contributions to herbal medicine. He experienced a warm and sexually pleasurable feeling after chewing the root. He advocated this as a treatment for erectile dysfunction and used it to stimulate sexual appetite. The reputation of ginseng as an aphrodisiac is based on the doctrine of signatures, since the adult root has a phallic shape. Shen-Nung believed that ginseng's resemblance to the human form is proof of its rejuvenative and aphrodisiac properties. It was believed that the closer the similarity to the human figure, the more potent the root. The use of ginseng for erectile dysfunction by Emperor Shen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on.

  2. [Investigation on supplements from Tang Edition (TE) cited in Jia You ben cao (Materia medica of Jia You reign)].

    PubMed

    Yu, Shun

    2004-01-01

    Xin xiu ben cao (Newly Revised Materia Medica), also called Tang ben cao (Materia Medica of the Tang Dynasty) is the first state pharmacopoeia in the world, the original edition of which was lost yet cited by various books. After analyzing the TE in Jia You ben cao (Materia Medica of Jia You Reign) supplemantarily cited by Zhang Yuxi in the Song Dynasty, the author holds that Zhang himself didn't witness Xin xiu ben cao (Newly Revised Materia Medica) and the so-called TE ought to be derived from Shu ben cao (Materia Medica of Sichuan) because both share the same features. Inference can also be drawn that Xin xiu ben cao (Newly Revised Materia Medica) might have been lost at the time when Jia You ben cao (Materia Medica of Jia You Reign) was compiled in the 2nd year of Jia You Reign (A.D.1057). As the TE was not directly extracted from Xin xiu ben cao (Newly Revised Materia Medica), the trustworthiness of the texts allegedly cited from Xin xiu ben cao should be evaluated in many ways and it should be dealt with prudently while recompiling Xin xiu ben cao (Newly Revised Materia Medica).

  3. No Chemisorption on Ni(111): Coverage Effects, Site Preferences and Adsorption Geometry.

    DTIC Science & Technology

    1985-09-03

    U 01TECHNICAL REPORT No. 14 In NO CHEMISORPTION ON Ni(111): COVERAGE EFFECTS, SITE PREFERENCES AND ADSORPTION GEOMETRY by Shen-Shu Sung, Roald ...Adsorption Geometry 6. pER Op ,,GoRG. R --OAT NUmSER 7. ;.-.; T) hOR ( 2) .\\B. CONTRACT OR GRANT N’,UMaEA.I) Shen-Shu Sung, Roald Hoffman and Patricia...PREFERENCES AND ADSORPTION GEOMETRY Shen-Shu Sung , Roald Hoffmann and Patricia A. ThielT t Departent of Chemistry, Cornell University, Ithaca, NY 14853

  4. Effect of H2O2 on fiber initiation using fiber retardation initiation mutants in cotton (Gossypium hirsutum).

    PubMed

    Zhang, Dayong; Zhang, Tianzhen; Guo, Wangzhen

    2010-03-15

    Single-celled fibers initiate at anthesis from cotton seed epidermal cells of normal developmental cotton cultivars; however, fiber initiation is retarded in some cotton fiber mutants. In this study, the relationship between genes associated with fiber initiation retardation and fiber initiation development was investigated using three cotton fiber developmental mutants: recessive naked seed n2; dominant naked seed N1; and Xinxiangxiaoji Linted-Fuzzless Mutant (XinFLM); with genetic standard line TM-1 (TM-1) as control. Retardation during fiber initiation development was observed in N1 and XinFLM by scanning electron microscope (SEM) analysis. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of genes related to the fiber initiation development showed that the expression of GhEXP1 and GhMYB25 was lower in N1 and XinFLM than in TM-1 and n2, however, the expression of GhTTG1 and GhTTG3 in XinFLM and n2 was higher than in TM-1 and N1. In vivo and in vitro treatments on ovules demonstrated that 30% hydrogen peroxide (H2O2) could prevent fiber initiation retardation in XinFLM, but no evident effect on N1. To further confirm the relationship between gene expression and the effects of H2O2 in XinFLM, qRT-PCR analysis of four differentially expressed genes was performed using -1d post-anthesis (DPA) ovules of XinFLM treated for 24 and 48h with 30% H2O2 and H2O, respectively, with 0 and 1 DPA untreated ovules from XinFLM and TM-1 as control. The results showed that the expression of GhMYB25 and GhEXP1 showed significant difference in XinFLM after -1 DPA ovule treated for 24h relative to the untreated or H2O-treated ovules, with the expression of GhMYB25 increased significantly and that of GhEXP1 decreased. This implied that H2O2 might be one of the upstream signal molecules affecting the expression of GhMYB25 and GhEXP1 genes. The fiber initiation retardation in XinFLM might be related to the production of reactive oxygen species (ROS).

  5. [Important action of improving adrenocortical function for certain diseases recovery].

    PubMed

    Shen, Zi-yin; Dong, Jing-cheng; Cai, Ding-fang

    2007-04-01

    It has been found that the hypofunction status of hypothalamus-pituitary-adrenal (HPA) axis exists in patients with Shen-yang deficiency syndrome of TCM, also presents in most asthma patients. Seasonal attack of asthma can be prevented with Shen-tonifying drugs by improving adrenocortical function. Since patients subject to long-term glucocorticoids display hypofunction condition of HPA axis, Shen-tonifying drugs should be helpful to gluocorticoid withdrawal for getting higher success rate. Basic researches also indicated that the activating of adrenocortical stem cells and promoting regeneration of adrenal cortex is one of the mechanisms underlying improvement of adrenocortical function. Series of research showed that hypofunction of adrenocortex is the general pathological change in some diseases, so, Shen-tonifying drugs act a part in unitarily modulating the adrenocortical function, to get the therapeutic effect of both regulating the whole and improving the local.

  6. Muscular Dystrophy

    MedlinePlus

    ... It Like for Teens With MD? en español Distrofia muscular Aside from seeing the telethon on Labor ... which weakens different muscle groups in various ways: Duchenne (pronounced: due-SHEN) muscular dystrophy (DMD) , the most ...

  7. Essential oil composition analysis of three cultivars seeds of Resina ferulae from Xinjiang, China.

    PubMed

    Li, Xiaojin; Wang, Yue'e; Zhu, Jun; Xiao, Qiong

    2011-04-01

    Three cultivars seeds of Resina ferulae were analyzed for essential oil composition, Ferula sinkiangensis K. M. Shen, Ferula fukangensis K. M. Shen, and Ferula ovina, investigated differences among different genera of medicinal R. ferulae. The essential oils were extracted by the method of hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS), using normalization method to calculate relative amount. Twenty-six compounds were identified in F. sinkiangensis K. M. Shen, comprised 99.001% of total essential oil; 21 compounds were identified in F. fukangensis K. M. Shen, comprised 100% of total essential oil; 25 compounds were identified in F. ovina, comprised 99.459% of total essential oil. n-Propyl sec-butyl disulfide is the main component in three cultivars seeds of R. ferulae, accounting for 55.875%, 49.797%, 53.781%, respectively. Little diversity among three cultivars seeds of R. ferulae from Xinjiang.

  8. Essential oil composition analysis of three cultivars seeds of Resina ferulae from Xinjiang, China

    PubMed Central

    Li, Xiaojin; Wang, Yue’e; Zhu, Jun; Xiao, Qiong

    2011-01-01

    Objective: Three cultivars seeds of Resina ferulae were analyzed for essential oil composition, Ferula sinkiangensis K. M. Shen, Ferula fukangensis K. M. Shen, and Ferula ovina, investigated differences among different genera of medicinal R. ferulae. Materials and Methods: The essential oils were extracted by the method of hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS), using normalization method to calculate relative amount. Results: Twenty-six compounds were identified in F. sinkiangensis K. M. Shen, comprised 99.001% of total essential oil; 21 compounds were identified in F. fukangensis K. M. Shen, comprised 100% of total essential oil; 25 compounds were identified in F. ovina, comprised 99.459% of total essential oil. n-Propyl sec-butyl disulfide is the main component in three cultivars seeds of R. ferulae, accounting for 55.875%, 49.797%, 53.781%, respectively. Conclusion: Little diversity among three cultivars seeds of R. ferulae from Xinjiang. PMID:21716620

  9. A new leafhopper genus Bhatiahamus (Hemiptera: Cicadellidae: Deltocephalinae) from China with description of a new species and a new combination.

    PubMed

    Lu, Lin; Zhang, Yalin

    2014-07-11

    A new leafhopper genus, Bhatiahamus gen. nov., is established for B. flabellatus (Shang & Shen) n. comb. (Bhatia) (type species) and B. sinuatus sp. nov., both from China. A key to distinguish the two species is provided. 

  10. Survivability in Layered Networks

    DTIC Science & Technology

    2011-02-01

    Karmi. Lightpath communications: a novel ap- proach to high bandwidth optical WANs . IEEE Transactions on Communica- tions, 40(7):1171-1182, 1992. [301...discovery of Shared Risk Link Groups. In Optical Fiber Communication Conference, March 2001. 11011 Arunabha Sen, Bin Hao, and Bao Hong Shen. Survivable...IEEE Computer Society. [102] Arunabha Sen, Bin Hao, and Bao Hong Shen. Minimum cost ring survivability in WDM networks. In Workshop on High Performance

  11. Lightweight Zerodur Mirror Technology Technical Report Analysis Condensation Evaluation (TRACE)

    DTIC Science & Technology

    2007-11-02

    Report No. 15514 LIGHTWEIGHT ZERODUR MIRROR TECHNOLOGY TECHNICAL REPORT ANALYSIS CONDENSATION EVALUATION (TRACE) George J. Gardopee Da-Wun Shen... Zerodur Mirror Technology: Technical Report Analysis Condensation Evaluation (TRACE) Personal Author: Gardopee, G.J.; Shen, D-W. Corporate Author Or... mirrors have shown that Zerodur Glass- Ceramic is an attractive alternative to ULE glass because of its low coefficient of thermal expansion (CTE

  12. Elucidation of the Molecular Mechanism Underlying Lymph Node Metastasis in Prostate Cancer

    DTIC Science & Technology

    2006-10-01

    1 -0901 TITLE: Elucidation of the Molecular Mechanism Underlying Lymph Node Metastasis in Prostate Cancer PRINCIPAL...Mechanism Underlying Lymph Node Metastasis in Prostate Cancer 5b. GRANT NUMBER W81XWH-04- 1 -0901 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...upregulate VEGF-C in prostate cancer . Reference: 1 . Abate-Shen C and Shen MM. Molecular genetics of prostate cancer . Genes Dev 14:

  13. Improved UV Nitride Light Emitting Diode With Engineered Spontaneous and Piezoelectric Charges

    DTIC Science & Technology

    2008-12-01

    Shen, Y. C., Chen, G., Watanabe, S., Goetz, W., and Krames, M. R., 2007, Blue- emitting InGaN –GaN double-heterostructure light- emitting diodes...IMPROVED UV NITRIDE LIGHT EMITTING DIODE WITH ENGINEERED SPONTANEOUS AND PIEZOELECTRIC CHARGES Paul Hongen Shen, Meredith L. Reed, Eric D...nitride light emitting diodes have an n-type down structure with Ga polarity. In such a device, the active layer is grown on top of the n-cladding

  14. The Chinese Diaspora: China’s Instrument of Power

    DTIC Science & Technology

    2010-06-01

    Bail and Wei Shen, ―Le retour des ‗cerveaux‘ en Chine: quel impact socio- politique?‖ Asie.Visions, no. 11, IFRI (November 2008), 30. 20 The...more than 2,000 Overseas Chinese students associations. According to scholars Hélène Le Bail and Wei Shen, many of these associations have ties to...responded by chartering aircraft and flying out 200 of its ethnic kin.8 5 San Diego Chinese Community

  15. A Mouse Model for Prostate Cancer

    DTIC Science & Technology

    2001-07-01

    were: monoclonal antibody against smooth muscle actin (Sigma); monoclonal antibody against cytokeratin 14 (Biogenex); monoclonal antibody against CD1O5...generally explain the tissue-specific phenotypes of cancers. 12 DOD Annual Report/DAMD17-00-1-0091 Cory Abate-Shen VI. References 1. Jacks, T., Tumor...Stein, S. Greenfield, N., Seidman, C.E., Seidman, J.G., and Abate-Shen, C. (1998). Haploinsufficiency of MSX1: A mechanism for selective tooth agenesis

  16. Surprise-Based Learning for Autonomous Systems

    DTIC Science & Technology

    2009-02-28

    based learning was first proposed by Shen and Simon in 1989 [I] and later formalized as Complementary Discrimination Learning [2-4]. This learning...paradigm stems from Piaget’s theory of Developmental Psychology [5], Herben Simon’s theory on dual-space search for knowledge and problem solving [6...25] [26] [27] [28] [29] Shen, W.-M., Simon H., "Rule creation and rule learning through environmental exploration", Eleventh Joint Conference

  17. Controlling Protein Conformation and Activities on Block-Copolymer Nanopatterns

    DTIC Science & Technology

    2013-10-24

    smll.201200673 09/11/2012 8.00 Lei Shen, Takuji Adachi, David Vanden Bout, X.-Y. Zhu. A Mobile Precursor Determines Amyloid-? Peptide Fibril Formation...journals: A mobile precursor determines amyloid-? peptide fibril formation at the liquid-solid interface, ACS National Meeting, September 2012. (c...3.00 Lei Shen, Takuji Adachi, David Vanden Bout, X.-Y. Zhu. A mobile precursor determines amyloid-? peptide fibril formation at the liquid-solid

  18. X indening oral liquid improves cardiac function of rats with chronic cardiac failure via TGF-ß1/Smad3 and p38 MAPK pathway.

    PubMed

    Wei, Yunliang; Guo, Changsheng; Zhao, Jingsheng; Yang, Jun; Yi, Weiguo; Liu, Hong; Lin, Xinwei; Zhang, Zhengchen

    2017-05-01

    Xindening oral liquid (Xin) is a widely used traditional Chinese medicine for the treatment of chronic heart failure (CHF). However, the exact mechanisms related to its therapeutic effects against CHF remain unclear. In the present study, we investigate the effects of Xin on cardiac function in CHF rats and the possible mechanisms involved. Transverse aortic constriction (TAC) was conducted to induce a CHF rat model in this study. Sixty male Wistar rats were randomly assigned to six groups 28 days after TAC: sham; CHF model; Xin at concentrations of 5 ml/kg, 10 mL/kg, and 20 mL/kg; and QiLi 0.6 g/kg. After four weeks, the rats were treated with Xin (5, 10, or 20 mL/kg/d) for six weeks consecutively. At the end of the study, the cardiac function, heart weight index (HWI) and left ventricular mass index (LVMI), serum level of LDH, B-type natriuretic peptide (BNP), cTnI and CK-MB, and collagen volume fraction were studied. The expression of transforming growth factor-ß1 (TGF-ß1), drosophila mothers against decapentaplegic protein 3 (Smad3), and p38 mitogen activated protein kinase (p38 MAPK) were detected. The results showed that Xin treatment significantly improved cardiac function but decreased the serum level of LDH, BNP, cTnI, and CKMB of CHF rats. In addition, it reduced the HWI, LVMI, and collagen volume fraction compared with the model group. Xin treatment significantly improved cardiac function and attenuated cardiac fibrosis by suppressing the p38 MAPK and TGF-ß1/Smad3 signaling pathway in CHF rats. These results suggested that Xin might be a promising complementary treatment for CHF. More detailed experimental studies will be carried out in our subsequent research.

  19. A secure key agreement protocol based on chaotic maps

    NASA Astrophysics Data System (ADS)

    Wang, Xing-Yuan; Luan, Da-Peng

    2013-11-01

    To guarantee the security of communication in the public channel, many key agreement protocols have been proposed. Recently, Gong et al. proposed a key agreement protocol based on chaotic maps with password sharing. In this paper, Gong et al.'s protocol is analyzed, and we find that this protocol exhibits key management issues and potential security problems. Furthermore, the paper presents a new key agreement protocol based on enhanced Chebyshev polynomials to overcome these problems. Through our analysis, our key agreement protocol not only provides mutual authentication and the ability to resist a variety of common attacks, but also solve the problems of key management and security issues existing in Gong et al.'s protocol.

  20. Long-period oscillations of sunspot magnetic fields by simultaneous observations of the Global Oscillation Network Group and Solar and Heliospheric Observatory/Michelson Doppler imager

    NASA Astrophysics Data System (ADS)

    Efremov, V. I.; Parfinenko, L. D.; Solov'ev, A. A.; Riehokainen, A.

    2016-12-01

    For the first time, the ultra-low oscillation mode of the sunspot magnetic field strength has been detected with a high degree of confidence by ground-based observations of sunspots with the Global Oscillation Network Group (GONG) network of telescopes. Synchronous series of magnetograms derived from the GONG and Solar and Heliospheric Observatory/Michelson Doppler Imager (SOHO/MDI) have been processed. They were obtained on September 27-30, 2010, for the active region NOAA 11109 with a total duration of 80 h. The periods of magnetic field oscillations found by space data coincide with the periods defined with GONG. This confirms the physical reality of the oscillatory process. The power spectrum contains harmonics with periods of 26 h, 8-10 h, and 3-4 h.

  1. Differential Rotation and Dynamics of the Solar Interior

    PubMed

    Thompson; Toomre; Anderson; Antia; Berthomieu; Burtonclay; Chitre; Christensen-Dalsgaard; Corbard; DeRosa; Genovese; Gough; Haber; Harvey; Hill; Howe; Korzennik; Kosovichev; Leibacher; Pijpers; Provost; Rhodes; Schou; Sekii; Stark; Wilson

    1996-05-31

    Splitting of the sun's global oscillation frequencies by large-scale flows can be used to investigate how rotation varies with radius and latitude within the solar interior. The nearly uninterrupted observations by the Global Oscillation Network Group (GONG) yield oscillation power spectra with high duty cycles and high signal-to-noise ratios. Frequency splittings derived from GONG observations confirm that the variation of rotation rate with latitude seen at the surface carries through much of the convection zone, at the base of which is an adjustment layer leading to latitudinally independent rotation at greater depths. A distinctive shear layer just below the surface is discernible at low to mid-latitudes.

  2. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Point Gong Buoy “1AHP” 42°42.0′ 70°37.5′ 12. Connecting reference point 42°40′ 70°30′ 13. Whistle Buoy...′ 71°32.1′ 34. Shinnecock Inlet Lighted Whistle Buoy “SH” 40°49.0′ 72°28.6′ 35. Scotland Horn Buoy “S”, off Sandy Hook (NJ) 40°26.5′ 73°55.0′ 36. Barnegat Lighted Gong Buoy “2” 39°45.5′ 73°59.5′ 37. A...

  3. Hardened Lava Meets Wind on Mars

    NASA Technical Reports Server (NTRS)

    2006-01-01

    NASA's Mars Exploration Rover Spirit used its microscopic imager to capture this spectacular, jagged mini-landscape on a rock called 'GongGong.' Measuring only 3 centimeters (1.2 inches) across, this surface records two of the most important and violent forces in the history of Mars -- volcanoes and wind.

    GongGong formed billions of years ago in a seething, stirring mass of molten rock. It captured bubbles of gases that were trapped at great depth but had separated from the main body of lava as it rose to the surface. Like taffy being stretched and tumbled, the molten rock was deformed as it moved across an ancient Martian landscape. The tiny bubbles of gas were deformed as well, becoming elongated. When the molten lava solidified, the rock looked like a frozen sponge.

    Far from finished with its life, the rock then withstood billions of years of pelting by small sand grains carried by Martian dust storms that sometimes blanketed the planet. The sand wore away the surface until, little by little, the delicate strands that enclosed the bubbles of gas were breached and the spiny texture we see today emerged.

    Even now, wind continues to deposit sand and dust in the holes and crevices of the rock.

    Similar rocks can be found on Earth where the same complex interplay of volcanoes and weathering occur, whether it be the pelting of rocks by sand grains in the Mojave desert or by ice crystals in the frigid Antarctic.

    GongGong is one of a group of rocks studied by Spirit and informally named by the Athena Science Team to honor the Chinese New Year (the Year of the Dog). In Chinese mythology, GongGong was the god-king of water in the North Land. When he sacrificed his life to knock down Mount BuZhou, he defeated the bad Emperor in Heaven, freed the sun, moon and stars to go from east to west, and caused all the rivers in China to flow from west to east.

    Spirit's microscopic imager took this image during on the rover's 736th day, or sol, of

  4. Hardened Lava Meets Wind on Mars

    NASA Technical Reports Server (NTRS)

    2006-01-01

    NASA's Mars Exploration Rover Spirit used its microscopic imager to capture this spectacular, jagged mini-landscape on a rock called 'GongGong.' Measuring only 3 centimeters (1.2 inches) across, this surface records two of the most important and violent forces in the history of Mars -- volcanoes and wind.

    GongGong formed billions of years ago in a seething, stirring mass of molten rock. It captured bubbles of gases that were trapped at great depth but had separated from the main body of lava as it rose to the surface. Like taffy being stretched and tumbled, the molten rock was deformed as it moved across an ancient Martian landscape. The tiny bubbles of gas were deformed as well, becoming elongated. When the molten lava solidified, the rock looked like a frozen sponge.

    Far from finished with its life, the rock then withstood billions of years of pelting by small sand grains carried by Martian dust storms that sometimes blanketed the planet. The sand wore away the surface until, little by little, the delicate strands that enclosed the bubbles of gas were breached and the spiny texture we see today emerged.

    Even now, wind continues to deposit sand and dust in the holes and crevices of the rock.

    Similar rocks can be found on Earth where the same complex interplay of volcanoes and weathering occur, whether it be the pelting of rocks by sand grains in the Mojave desert or by ice crystals in the frigid Antarctic.

    GongGong is one of a group of rocks studied by Spirit and informally named by the Athena Science Team to honor the Chinese New Year (the Year of the Dog). In Chinese mythology, GongGong was the god-king of water in the North Land. When he sacrificed his life to knock down Mount BuZhou, he defeated the bad Emperor in Heaven, freed the sun, moon and stars to go from east to west, and caused all the rivers in China to flow from west to east.

    Spirit's microscopic imager took this image during on the rover's 736th day, or sol, of

  5. Microwave, Semiconductor Research - Materials, Devices and Circuits.

    DTIC Science & Technology

    1984-03-01

    Appl. Phys., 53 (9) 6208-6213 (Sept. 1982). 1. 2. "Investigation of Capless Heat Treatment of MBE n-GaAs", S.H. Xin, W.J. Schaff, C.E.C. Wood and L.F...4 I 4. "Capped Versus Capless Heat Treatment of MBE n-GaAs", S.H. Xin, W.J. Schaff, C.E.C. Wood and L.F. Eastman, Appl. Phys. Lett., 41 (8) 742...Capless Heat Treatment of Molecular Beam Epitaxial GaAs", S.H. Xin, W.J. Schaff, C.E.C. Wood and L.F. Eastman, Appl. Phys. Lett., 41 (8) 742-744 (Oct

  6. Boundedness in a quasilinear chemotaxis-haptotaxis system with logistic source

    NASA Astrophysics Data System (ADS)

    Liu, Ji; Zheng, Jiashan; Wang, Yifu

    2016-04-01

    In this paper, we consider the quasilinear chemotaxis-haptotaxis system u_t=nabla\\cdot(D(u)nabla u)-nabla\\cdot(S_1(u)nabla v)-nabla\\cdot(S_2(u)nabla w)+uf(u,w),quad xinΩ, t > 0,v_t=Δ v-v+u,quad xinΩ, t > 0,w_t=-vw,quad xinΩ, t > 0 in a bounded smooth domain {Ωsubset R^n (n≥1)} under zero-flux boundary conditions, where the nonlinearities {D, S_1} and {S_2} are assumed to generalize the prototypes D(u)=CD(u+1)^{m-1}, S_1(u)=C_{S_1}u(u+1)^{q_1-1} quad {and} quad S_2(u)=C_{S_2}u(u+1)^{q_2-1} with {C_D,C_{S_1},C_{S_2} > 0, m,q_1,q_2in R} and {f(u,w)in C^1([0,+infty)×[0,+∞))} fulfills f(u,w)≤ r-buquad {for all} ~u≥ 0quad {and} quad w≥ 0, where {r > 0, b > 0.} Assuming nonnegative initial data {u_0(x)in W^{1,∞}(Ω),v_0(x)in W^{1,∞}(Ω)} and {w_0(x)in C^{2,α}(barΩ)} for some {αin(0,1),} we prove that (i) for {n≤2,} if q_1,q_2\\ < m+2/n-1,} then {(star)} has a unique nonnegative classical solution which is globally bounded, (ii) for {n > 2,} if {max{q_1,q_2} < m+2/n-1} and {m > 2-2/n} or {max{q_1,q_2} < m+2/n-1} and {m≤ 1,} then {(star)} has a unique nonnegative classical solution which is globally bounded.

  7. A Computer Program Package for Introductory One-Dimensional Digital Signal Processing Applications.

    DTIC Science & Technology

    1988-03-01

    DISCRETE FURIER TRANSFUR4 (DFT) C OF THE ARRAY, AND RMTRS THE RESULTING SEQENCE IN THE C COMPLEX ARRAY xouto. subroutine dft (N, xin, xout) complex xin(0...C DISCRETE FURIER TRANSFORM OF AN ARRAY. TIHE TW C sU XINE sampll AND savpl2 ALLOW HE USER TO C GEDERATE EITHER. OF THE INPUT ARRAYS BY WRITING THE C...TRANSFO1R4 C OF AN ARRA USING THE RADI FFT ALGORIII M E 1 C SUROTINE invfft COMPUTES THE INVERSE DISCRETE C FURIER TRANSFORM OF AN ARRAY USING THE

  8. Rate and Confinement Effects on Cracking and Failure in Uniaxial Compression of Concrete

    DTIC Science & Technology

    1992-11-10

    Gong, "Dynamic Compressive Strength of Cementitious Materials," Materials Research Society, Symposium Proceedings, Vol. 64, eds. S. Mindess and S. P...Proceedings, Vol. 64, eds. S. Mindess and S. P. Shah, Materials Research Society, Pittsburgh, PA, 1986, pp. 63-77. 27. E. P. Chen, "A Continuum Damage Model

  9. World Music Ensemble: Kulintang

    ERIC Educational Resources Information Center

    Beegle, Amy C.

    2012-01-01

    As instrumental world music ensembles such as steel pan, mariachi, gamelan and West African drums are becoming more the norm than the exception in North American school music programs, there are other world music ensembles just starting to gain popularity in particular parts of the United States. The kulintang ensemble, a drum and gong ensemble…

  10. Navigation Rules, International-Inland

    DTIC Science & Technology

    1977-05-01

    COAST 82.127 Crescent City Harbor. 82.5 All harbors on the coast of 82.129 Arcata-Humboldt Bay. Maine, New Hampshire, and 82.181 Bodega and Tomales Bays...thence to Bodega Harbor Approach Lighted Gong Buoy BA; thence to the southernmost extremity of Bodega Head. 1 82.133 San Francisco Harbor. A straight

  11. Potential for Occupational Exposure to Engineered Carbon-Based Nanomaterials in Environmental Laboratory Studies

    DTIC Science & Technology

    2009-09-01

    as asbestos. Environmental researchers are actively examining the fate and effects on CNMs in environmentally-relevant systems ( Asharani et al...carbon nanotubes. Topics Appl Phys 80:391- 425. Asharani PV, Serina NG, Nurmawati MH, Gong Z, Valiyaveettil S. 2008. Impact of multi- walled carbon

  12. The Processing and Mechanical Properties of High Temperature/High Performance Composites. Book 6, Section 4: Processing: Matrices and Composites. Part 2

    DTIC Science & Technology

    1989-10-15

    Processing C. McCullough J. Rosler C.G. Levi R. Mehrabian 66. Numerical Modelling of the Planar Flow Z. Gong Melt-Spinning Process, and Experimental P...89Ros] J. Rosler , T.C. Lu, and R. Mehrabian, University of California at Santa Barbara, unpublished research. [89VML] J.J. Valencia, C. McCullough

  13. Adaptive Channel Estimation for Multiple-Input Multiple-Output Frequency Domain Equalization

    DTIC Science & Technology

    2005-01-01

    FDE) in a single carrier (SC) multiple - input multiple - output ( MIMO ) system. Two types of channel estimation methods are proposed, assuming...Adaptive Channel Estimation for Multiple - Input Multiple - Output Frequency Domain Equalization Xu Zhu*, Fareq Malek*, Yi Gong+ and Yi Huang...perfect channel state information (CSI), and has a fast convergence speed and reasonably low complexity. Keywords- Multiple - Input Multiple - Output

  14. 33 CFR 83.33 - Equipment for sound signals (Rule 33).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Equipment for sound signals (Rule... INLAND NAVIGATION RULES RULES Sound and Light Signals § 83.33 Equipment for sound signals (Rule 33). (a... gong, the tone and sound of which cannot be confused with that of the bell. The whistle, bell and...

  15. 33 CFR 83.33 - Equipment for sound signals (Rule 33).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Equipment for sound signals (Rule... INLAND NAVIGATION RULES RULES Sound and Light Signals § 83.33 Equipment for sound signals (Rule 33). (a... gong, the tone and sound of which cannot be confused with that of the bell. The whistle, bell and...

  16. 33 CFR 83.33 - Equipment for sound signals (Rule 33).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Equipment for sound signals (Rule... INLAND NAVIGATION RULES RULES Sound and Light Signals § 83.33 Equipment for sound signals (Rule 33). (a... gong, the tone and sound of which cannot be confused with that of the bell. The whistle, bell and...

  17. 33 CFR 83.33 - Equipment for sound signals (Rule 33).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Equipment for sound signals (Rule... INLAND NAVIGATION RULES RULES Sound and Light Signals § 83.33 Equipment for sound signals (Rule 33). (a... gong, the tone and sound of which cannot be confused with that of the bell. The whistle, bell and...

  18. 33 CFR 83.33 - Equipment for sound signals (Rule 33).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Equipment for sound signals (Rule... INLAND NAVIGATION RULES RULES Sound and Light Signals § 83.33 Equipment for sound signals (Rule 33). (a... gong, the tone and sound of which cannot be confused with that of the bell. The whistle, bell and...

  19. Defining Traditional Forms of Communication in Nigerian Culture within the Context of Nonverbal Communication.

    ERIC Educational Resources Information Center

    Ogbondah, Chris; Siddens, Paul J., III

    Drum language, gong language, masquerades, and puppet theater, the traditional forms of communication found in Nigerian culture, reflect tensions that exist between oral and literate cultures. Drum language ranges from simple signals to elaborately coded messages and is learned through both formal and informal educational processes. Formal…

  20. Teaching Counselors Self-Care through Mindfulness Practices

    ERIC Educational Resources Information Center

    Newsome, Sandy; Christopher, John Chambers; Dahlen, Penny; Christopher, Suzanne

    2006-01-01

    Few counseling programs directly address the importance of self-care in reducing stress and burnout in their curricula. A course entitled Mind/Body Medicine and the Art of Self-Care was created to address personal and professional growth opportunities through self-care and mindfulness practices (meditation, yoga, gong, and conscious relaxation…

  1. Supercomputer Assembly and Annotation of Transcriptomes for Assessing Impacts of Army Stressors on Ecological Receptors

    DTIC Science & Technology

    2010-01-01

    sentinel species such as Northern Bobwhite (Colinus virginianus), Fathead Minnow (Pimephales promulus), Earthworm (Eisenia fetida), Western Fence...of RDX and TNT interactive sublethal effects in the earthworm Eisenia fetida. BMC Genomics. 9 (Suppl 1):S15. Gong, P., Guan, X., Inouye, LS

  2. Harbor in the Storm: Institutional Research in the Age of Accountability. NEAIR 36th Annual Conference Proceedings (Baltimore, Maryland, November 7-10, 2009)

    ERIC Educational Resources Information Center

    D'Alessandro, Michael, Ed.

    2009-01-01

    The NEAIR 2009 Conference Proceedings is a compilation of papers presented at the Baltimore, Maryland conference. Papers in this document include: (1) A Principle Components Analysis of The Determinants of Student Satisfaction at a Historically Black Institution (Tao Gong and Jacqueline V. Parham); (2) Assessing and Enhancing Graduates'…

  3. Mindfulness Group Work: Preventing Stress and Increasing Self-Compassion among Helping Professionals in Training

    ERIC Educational Resources Information Center

    Newsome, Sandy; Waldo, Michael; Gruszka, Clare

    2012-01-01

    This study examined the effects a 6-week mindfulness group had on 31 college students who were intending to enter helping professions (e.g., nursing, social work, counseling, psychology, and teaching). Group activities included meditation, yoga, a body scan exercise, and qi gong. The group members completed the Perceived Stress Scale, the…

  4. IQs Predict Differences in the Technological Development of Nations from 1000 BC through 2000 AD

    ERIC Educational Resources Information Center

    Lynn, Richard

    2012-01-01

    National IQs and measures of technological development given by Comin, Easterly and Gong (2010) are presented for 133 nations for the year 1000 BC, for 134 nations for 0 AD, for 120 nations for 1500 AD and for 133 nations for 2000 AD. It is shown that national IQs are significantly correlated with national differences in technological development…

  5. CNN Newsroom Classroom Guides, October 2000.

    ERIC Educational Resources Information Center

    Turner Educational Services, Inc., Newtown, PA.

    These classroom guides, designed to accompany the daily CNN (Cable News Network) Newsroom broadcasts for the month of October 2000, provide program rundowns, suggestions for class activities and discussion, student handouts, and a list of related news terms. Top stories include: Chinese authorities detain Falun Gong protesters on Tiananmen Square…

  6. UNUSUAL TRENDS IN SOLAR P-MODE FREQUENCIES DURING THE CURRENT EXTENDED MINIMUM

    SciTech Connect

    Tripathy, S. C.; Jain, K.; Hill, F.; Leibacher, J. W.

    2010-03-10

    We investigate the behavior of the intermediate-degree mode frequencies of the Sun during the current extended minimum phase to explore the time-varying conditions in the solar interior. Using contemporaneous helioseismic data from the Global Oscillation Network Group (GONG) and the Michelson Doppler Imager (MDI), we find that the changes in resonant mode frequencies during the activity minimum period are significantly greater than the changes in solar activity as measured by different proxies. We detect a seismic minimum in MDI p-mode frequency shifts during 2008 July-August but no such signature is seen in mean shifts computed from GONG frequencies. We also analyze the frequencies of individual oscillation modes from GONG data as a function of latitude and observe a signature of the onset of the solar cycle 24 in early 2009. Thus, the intermediate-degree modes do not confirm the onset of the cycle 24 during late 2007 as reported from the analysis of the low-degree Global Oscillations at Low Frequency frequencies. Further, both the GONG and MDI frequencies show a surprising anti-correlation between frequencies and activity proxies during the current minimum, in contrast to the behavior during the minimum between cycles 22 and 23.

  7. Wireless Network Security Using Randomness

    DTIC Science & Technology

    2012-06-19

    REPORT WIRELESS NETWORK SECURITY USING RANDOMNESS 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: The present invention provides systems and methods for... securing communications in a wireless network by utilizing the inherent randomness of propagation errors to enable legitimate users to dynamically...Box 12211 Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS Patent, security , wireless networks, randomness Sheng Xiao, Weibo Gong

  8. The hepatic Igf2/H19 locus is not altered in 1-day old pups born to obese-prone Sprague-Dawley rats fed a low protein diet containing adequate folic acid

    USDA-ARS?s Scientific Manuscript database

    Gong et al. (Epigenetics, 2010) found, using diets low in folic acid, that compared to an 18% protein diet a 9% protein diet fed to pregnant Sprague-Dawley rats resulted in increased Igf2 and H19 gene expression in the liver of day 0 male offspring. In addition DNA methylation in the Imprinting Cont...

  9. Acceptance test report, plutonium finishing plant life safety upgrade

    SciTech Connect

    Hodge, S.G.

    1994-12-02

    This acceptance Test Procedure (ATP) has been prepared to demonstrate that modifications to the Fir Protection systems function as required by project criteria. The ATP will test the Fire Alarm Control Panels, Flow Alarm Pressure Switch, Heat Detectors, Smoke Detectors, Flow Switches, Manual Pull Stations, and Gong/Door By Pass Switches.

  10. World Music Ensemble: Kulintang

    ERIC Educational Resources Information Center

    Beegle, Amy C.

    2012-01-01

    As instrumental world music ensembles such as steel pan, mariachi, gamelan and West African drums are becoming more the norm than the exception in North American school music programs, there are other world music ensembles just starting to gain popularity in particular parts of the United States. The kulintang ensemble, a drum and gong ensemble…

  11. The Solar Chimes: Searching for Oscillations inside the Sun.

    ERIC Educational Resources Information Center

    Wentzel, Donat G.

    1991-01-01

    The importance of investigating the sun's interior is discussed. One method for probing the interiors of some pulsating stars is described. The relationship between the sun's solar oscillation frequencies and the sun's solar cycles is discussed. A project to place six instruments around the world to observe the sun's oscillations (GONG) is…

  12. CNN Newsroom Classroom Guides, October 2000.

    ERIC Educational Resources Information Center

    Turner Educational Services, Inc., Newtown, PA.

    These classroom guides, designed to accompany the daily CNN (Cable News Network) Newsroom broadcasts for the month of October 2000, provide program rundowns, suggestions for class activities and discussion, student handouts, and a list of related news terms. Top stories include: Chinese authorities detain Falun Gong protesters on Tiananmen Square…

  13. Studying Words That Teach Culture.

    ERIC Educational Resources Information Center

    Myers, Dan

    1996-01-01

    Discusses how the different conceptions of a "private world" between native English speakers and native Chinese speakers can result in misunderstandings. The study examines the semantic structures of two Chinese categories, "si" (i.e., private, selfish, illegal) and "gong" (i.e., public, unselfish, official). Results…

  14. ATF4, A Novel Mediator of the Anabolic Actions of PTH on Bone

    DTIC Science & Technology

    2009-07-01

    permeabilization (MOMP) and can be either pro- apoptotic (Bax, BAD, Bak, and Bok ) or anti-apoptotic (including Bcl-2, Bcl-xL, and Bcl-w) [Adams, 2003]. Atf4...Sivaprasad U. 1999. ATF3 and stress responses. Gene Expr 7:321–335. He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, Alam J. 2001. Identification of

  15. Mindfulness Group Work: Preventing Stress and Increasing Self-Compassion among Helping Professionals in Training

    ERIC Educational Resources Information Center

    Newsome, Sandy; Waldo, Michael; Gruszka, Clare

    2012-01-01

    This study examined the effects a 6-week mindfulness group had on 31 college students who were intending to enter helping professions (e.g., nursing, social work, counseling, psychology, and teaching). Group activities included meditation, yoga, a body scan exercise, and qi gong. The group members completed the Perceived Stress Scale, the…

  16. Teaching Counselors Self-Care through Mindfulness Practices

    ERIC Educational Resources Information Center

    Newsome, Sandy; Christopher, John Chambers; Dahlen, Penny; Christopher, Suzanne

    2006-01-01

    Few counseling programs directly address the importance of self-care in reducing stress and burnout in their curricula. A course entitled Mind/Body Medicine and the Art of Self-Care was created to address personal and professional growth opportunities through self-care and mindfulness practices (meditation, yoga, gong, and conscious relaxation…

  17. International Conference on Numerical Grid Generation in Computational Fluid Dynamics

    DTIC Science & Technology

    1989-04-30

    Sao Vicente 225 Washington, D.C. 20059 22453 Rio de Janerlo-- RJ BRA A.S. Dvinsky Haiqing Gong Creare Inc. University of Delaware Etna Road P.O. Box...Fulselage- Mounted Nacelle 77S /Pylon Configuration N. D. Halsey Zonal Grid Generation for Fighter Aircraft 785 E. H. Atta Geometric Modelling of

  18. Large Scale Solar Velocities on Time Scales up to Thirty Days

    NASA Astrophysics Data System (ADS)

    Beck, John Gunther

    1997-08-01

    This work studied solar supergranulation and methods of improving solar oscillation measurements. The supergranulation size scale and lifetime were found to be independent of heliographic latitude. The observed supergranule size scales were 31.7 ± 1.6 Mm in the East-West direction and 32.0 ± 1.6 Mm in the North-South direction; the mean lifetime was 23.4 ± 1.1 hours. Persistent granules were observed with the sizes of ~60 Mm and lifetimes of up to 160 hours, these features were found to affect supergranule lifetime measurements. Improvements of solar oscillation measurements were sought through three means: active region noise modeling, simulation the GONG instrument, and merging GONG data with IRIS data. The active region noise model, MDV, was tested and found promising. A simulation revealed a transmission profile ripple in the GONG instrument which could explain the observed velocity errors. A technique for merging GONG and IRIS data was developed and tested with satisfactory results.

  19. IQs Predict Differences in the Technological Development of Nations from 1000 BC through 2000 AD

    ERIC Educational Resources Information Center

    Lynn, Richard

    2012-01-01

    National IQs and measures of technological development given by Comin, Easterly and Gong (2010) are presented for 133 nations for the year 1000 BC, for 134 nations for 0 AD, for 120 nations for 1500 AD and for 133 nations for 2000 AD. It is shown that national IQs are significantly correlated with national differences in technological development…

  20. 77 FR 44310 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-27

    .... ALZOUMAN SARAH S. ANDERSON ERIC MOLTZAU AU-YEUNG RORCE BALL ROBERT JAMES BARKAS DIANNE JANET BARKAS ROY... BENJAMIN GONG CHENGQIAN GRENIER MARTIN GUT PHILIP CHRISTOPHER HAERING MARKUS PETER HEARREAN ELDA MARGUERITE... MICHAEL PETER ROOS RACHEL NATALIA ROPER III FRANK A. RYU KWANGHYUN DANIEL RYU SEUNGWOON SADIQ...

  1. Nuclear equation of state for core-collapse supernova simulations with realistic nuclear forces

    NASA Astrophysics Data System (ADS)

    Togashi, H.; Nakazato, K.; Takehara, Y.; Yamamuro, S.; Suzuki, H.; Takano, M.

    2017-05-01

    A new table of the nuclear equation of state (EOS) based on realistic nuclear potentials is constructed for core-collapse supernova numerical simulations. Adopting the EOS of uniform nuclear matter constructed by two of the present authors with the cluster variational method starting from the Argonne v18 and Urbana IX nuclear potentials, the Thomas-Fermi calculation is performed to obtain the minimized free energy of a Wigner-Seitz cell in non-uniform nuclear matter. As a preparation for the Thomas-Fermi calculation, the EOS of uniform nuclear matter is modified so as to remove the effects of deuteron cluster formation in uniform matter at low densities. Mixing of alpha particles is also taken into account following the procedure used by Shen et al. (1998, 2011). The critical densities with respect to the phase transition from non-uniform to uniform phase with the present EOS are slightly higher than those with the Shen EOS at small proton fractions. The critical temperature with respect to the liquid-gas phase transition decreases with the proton fraction in a more gradual manner than in the Shen EOS. Furthermore, the mass and proton numbers of nuclides appearing in non-uniform nuclear matter with small proton fractions are larger than those of the Shen EOS. These results are consequences of the fact that the density derivative coefficient of the symmetry energy of our EOS is smaller than that of the Shen EOS.

  2. Obituary: Clifford G. Toner (1959-2009)

    NASA Astrophysics Data System (ADS)

    Hill, Frank

    2011-12-01

    Cliff Toner passed away unexpectedly at home in Tucson, Arizona on March 29, 2009. For most of his career, Cliff was involved with the Global Oscillation Network Group (GONG), a facility of the National Solar Observatory in Tucson, Arizona. GONG is a set of instruments around the world to observe the inside of the sun using the sound that is trapped below the solar surface. This science is called helioseismology. Cliff Toner was born on December 8, 1959 in New Westminster, British Columbia near the western coast of Canada. After receiving his B.Sc. in Physics & Astronomy at the University of British Columbia at Vancouver in 1981, he headed east to the University of Western Ontario in London. His graduate school period was spent in collaboration with David F. Gray, with whom he received both an M.Sc. in Astronomy in 1984, and a Ph.D. in Astronomy in 1988. Toner actually wrote two theses at UWO, one on "Line Asymmetries in F, G, and K Supergiants and Bright Giants" for his M.Sc., and the other on "The Time Variability of Spectral Line Asymmetries and Equivalent Widths for the G8 Dwarf ? Boo A: Evidence for a Starpatch" for his Ph.D. After graduate school, Cliff Toner left the cool climate of Canada in 1988 and accepted a postdoctoral position in the warmer temperatures of Hawai'i at the Institute for Astronomy located at the University of Hawai'i in Honolulu. There he worked primarily with Barry LaBonte. At first, he continued his work on ? Boo A, but he became interested in the sun and helioseismology. This led to the discovery of halos of enhanced high-frequency acoustic power surrounding solar active regions (Ap.J. 415, 847). At the end of his post-doc, Cliff Toner was hired by the GONG project as a Data Scientist in 1991. He quickly tackled the problem of merging the data from the six GONG sites, which was the major data reduction challenge facing GONG at the time. In parallel, he and Stuart Jefferies developed an algorithm to measure the radii of full-disk solar

  3. Progress of integrative Chinese and Western medicine in treating polycystic ovarian syndrome caused infertility.

    PubMed

    Song, Juan-juan; Yan, Miao-e; Wu, Xiao-ke; Hou, Li-hui

    2006-12-01

    Polycystic ovarian syndrome (PCOS) is one of the most popular diseases that cause menstrual dysfunction and infertility in women. The present paper is a brief retrospection on the progress in treatment of PCOS caused infertility with integrative Chinese and Western medicine (ICWM). It can be seen from these materials that using traditional Chinese medicine (TCM) recipes formulated by Shen-replenishing herbs or acupuncture to reinforce Gan-Shen, regulate Chong-Ren Channels in treating PCOS, stable clinical efficacy could be obtained, with less adverse reaction, though the effect initiated somewhat late. Whereas, when Shen-replenishing recipe and acupuncture are combined with hormone or ovulation promoting drugs of Western medicine, the above-mentioned shortcomings would be overcome. So, this combined therapy is frequently used in clinical practice.

  4. Single-Cell Sequencing of Human Pancreatic Islets-New Kids on the Block.

    PubMed

    Prasad, Rashmi B; Groop, Leif

    2016-10-11

    RNA sequencing of human pancreatic islets has provided important insights into the islet transcriptome but little information on the specific cells. In this issue, Segerstolpe et al. (2016) and Xin et al. (2016b) report on the transcriptome of single pancreatic cells from non-diabetic and type 2 diabetic donors. Copyright © 2016. Published by Elsevier Inc.

  5. 78 FR 70918 - Final Determination of Sales at Less Than Fair Value: Silica Bricks and Shapes From the People's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... Advanced Material Co., Ltd. (collectively, ``New Century Group'') \\3\\ and its unaffiliated producer.... Import & Export Trading Co., Ltd. Ltd.; and XinYi American Advanced Material Co., Ltd. PRC-wide Entity... Freight Distances from Suppliers to Factory Packing Material Consumption Entered Value Brokerage and...

  6. 15 CFR Supplement No. 7 to Part 748 - Authorization Validated End-User (VEU): List of Validated End-Users, Respective Items Eligible...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., Pudong Zhangjiang Hi-Tech Park, Shanghai, China 201203.Applied Materials China, Ltd.—Beijing Depot c/o.... Applied Materials (Xi'an Ltd.) No. 28 Xin Xi Ave., Xi'an High Tech Park Export Processing Zone, Xi'an... High Tech Park, Pu Dong, Shanghai, China 201203. India GE India AIFACS Bldg., 1 Rafi Marg, New...

  7. The Relationship of Goldberg's Big Five Personality Trait Measures of Mid-Level Leaders at Midwest State-Supported Colleges and Universities to the Cameron and Quinn Competing Values Model

    ERIC Educational Resources Information Center

    Kempke Eppler, Michelle R.

    2012-01-01

    This dissertation expands previous work of Giberson, Resick, Dickson, Mitchelson, Randall, and Clark (2009), Zhang, Tsui, Song, & Jia (2008), and Tsui, Zhang, Wang, Xin, and Wu (2006) by examining higher education organizational culture and leadership. There is a paucity of research in examining the relationships between university mid-level…

  8. Development of Hydrophobic Coatings for Water-Repellent Surfaces Using Hybrid Methodology

    DTIC Science & Technology

    2014-04-01

    water-repellent, and antimicrobial properties. Several approaches have been investigated for the development of hydrophobic and superhydrophobic ...Effect: Superhydrophobicity and Metastability. Langmuir 2004, 20, 3517–3519. 2Liu, Y.; Chen, X.; Xin, J. H. Super-Hydrophobic Surfaces From a Simple

  9. 78 FR 78956 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... License Reza Rostami dba Pan World Trans (NVO & OFF), 5406 Juniper Court, Colleyville, TX 76034, Officer... Management, Inc. dba Pan World Trans Savitransport Inc. (NVO), 148-08 Guy R. Brewer Blvd., Jamaica, NY 11434... I, Palo Alto, CA 94306, Officer: Xin You, President (QI), Application Type: New NVO License Top...

  10. Active Metamaterial Based Terahertz Polarimeter for Spectroscopic Detection of Chemical and Biological Hazards

    DTIC Science & Technology

    2014-04-01

    Active Metamaterial Based Terahertz Polarimeter for Spectroscopic Detection of Chemical and Biological Hazards by Grace D. Metcalfe ...for Spectroscopic Detection of Chemical and Biological Hazards Grace D. Metcalfe and Michael Wraback Sensors and Electron Devices Directorate, ARL...GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Grace D. Metcalfe , Michael Wraback, Richard D. Averitt, and Xin Zhang 5d. PROJECT NUMBER

  11. Practitioner-Initiated Workplace-Based Conjoint Collaboration within an Adult Education Institution toward Democratic Schooling: A Distributed Leadership Perspective

    ERIC Educational Resources Information Center

    Fang, Ya-Hui; Huang, Shen-Tzay

    2015-01-01

    This paper examines an account of a practitioner-initiated transformation of workplace-based social relationship within a grassroots adult education institution. This tripartite relationship among adult students, staff and teachers, abbreviated as AST, is a major driving force for activities and missionary functioning of the XinZhuang Community…

  12. Will strangeness win the prize?

    NASA Astrophysics Data System (ADS)

    Kapusta, Joseph I.

    2001-03-01

    Five groups have made predictions involving the production of strange hadrons and entered them in a competition set up by Barbara Jacak, Xin-Nian Wang and myself in the spring of 1998 for the purpose of comparing with first-year physics results from RHIC. These predictions are summarized and evaluated.

  13. A Follow-Up Meta-Analysis for Word-Problem-Solving Interventions for Students with Mathematics Difficulties

    ERIC Educational Resources Information Center

    Zhang, Dake; Xin, Yan Ping

    2012-01-01

    Following a meta-analysis study conducted by Y. P. Xin and A. Jitendra (1999), the authors carried out a follow-up meta-analysis of word problem-solving interventions published from 1996 to 2009 for students with learning problems in mathematics. The authors examined the influence of education reforms as moderator variables on intervention…

  14. China Report: Political, Sociological and Military Affairs.

    DTIC Science & Technology

    1983-03-18

    Xu Qin, Zhao Engyi, Xin Junjie, Zhao Zhijian , Wang Zhaorong, (Yu Xiance), (Bai Yongchun), and Hou Dean), of the provincial party committee; Liu...Station; and Zhao Zhijian , Wang Zhaorong, (Yu Xiance), (Pei Dean), Zhang Yuqing, Xie Xianghua, Zhang Guozhen, Zhen Xiaoxian, (Xu Daolin), Lai Shaoyao

  15. Effect of site occupancy disorder on martensitic properties of Mn2NiIn type alloys: X-ray absorption fine structure study

    NASA Astrophysics Data System (ADS)

    Lobo, D. N.; Priolkar, K. R.; Koide, A.; Emura, S.

    2017-02-01

    We have carried out ab-initio calculations of the local structure of Mn and Ni in the Mn2Ni1.5In0.5 alloy with different site occupancies in order to understand the similarities in martensitic and magnetic properties of Mn2Ni1+xIn1-x and Ni2Mn1+xIn1-x alloys. Our results show that in Mn2Ni1+xIn1-x alloys, there is a strong possibility of Mn atoms occupying all the three X, Y, and Z sites of the X2YZ Heusler structure, while Ni atoms preferentially occupy the X sites. Such a site occupancy disorder of Mn atoms is in addition to a local structural disorder due to size differences between Mn and In atoms, which is also present in Ni2Mn1+xIn1-x alloys. Further, a comparison of the calculations with experimental x-ray absorption fine structure at the Mn and Ni K edges in Mn2-yNi1.6+yIn0.4 (-0.08 ≤ y ≤ 0.08) indicates a strong connection between martensitic transformation and occupancy of Z sites by Mn atoms.

  16. Synergic Investigation Of The Self-Assembly Structure And Mechanism Of Retroviral Capsid Proteins By Solid State NMR, Transmission Electron Microscopy And Multiscale simulation

    DTIC Science & Technology

    2017-03-29

    Current Topics, ACS Biochemistry . 2. Jaekyun Jeon, Xin Qiao, Ivan Hung, Alok K. Mitra, Ambroise Desfosses, Daniel Huang, Peter L. Gor’kov, Rebecca...and won Travel Award. Dr. Chen was invited to be the biochemistry session chair for 2016 American Chemical Society Florida Section (May 5-7, 2016) and

  17. Pseudocapacitor with High Energy and Power Densities Based on Nickel Oxide Nanostructures

    DTIC Science & Technology

    2012-01-11

    Electrospinning and Thermal Treatment" The Journal of Physical Chemistry C. 115: 373-378 7. Qi Lu, Xin Fan, Zachary J.Mellinger, Yunpeng Chen, Jingguang G.Chen and...34Fabrication, Formation Mechanism and Magnetic Properties of Metal Oxide Nanotubes via Electrospinning and Thermal Treatment" MRS Fall Meeting, Boston

  18. NEW BEDFORD, ACUSHNET RIVER ESTUARY WETLANDS ...

    EPA Pesticide Factsheets

    2013-06-11

    ... v:"" :x j x'"",; 1! •'•• A A / i • > •. \\ il'H V /-, '' If V^ '\\ «. i I--) ... '&S> i:;::: LL. •,"\\1 V\\\\j ,^ ! i... O W \\ \\ 1 '.|'J\\ \\ ' ,! r • wVJ x\\V?X\\in: 1 1.1.1 ...

  19. Metonymic-Based Metaphor--A Case Study on the Cognitive Interpretation of "Heart" in English and Chinese

    ERIC Educational Resources Information Center

    Qian, Li

    2016-01-01

    English is particularly rich in both metonymic and metaphorical expressions making use of the concept "heart" to speak of emotional issues (Niemeier, 2000). It is not difficult to find a large number of Chinese linguistic expressions in terms of "[Chinese characters omitted]" ("xin") ("heart")" to refer…

  20. Local Properties of Index-Alpha Stable Fields.

    DTIC Science & Technology

    1986-12-01

    not exhaust that class, e.g. Cambanis and Soltani (1983). Sufficient conditions for (3.1) and (3.2) to hold are respectively (3.5) lim suP XIN+aP4...The Geometry of Random Fields, John Wiley and Sons, New York. 2. Cambanis, S. and Soltani , A.R. (1983) "Prediction of stable processes: spectral and

  1. The Relationship of Goldberg's Big Five Personality Trait Measures of Mid-Level Leaders at Midwest State-Supported Colleges and Universities to the Cameron and Quinn Competing Values Model

    ERIC Educational Resources Information Center

    Kempke Eppler, Michelle R.

    2012-01-01

    This dissertation expands previous work of Giberson, Resick, Dickson, Mitchelson, Randall, and Clark (2009), Zhang, Tsui, Song, & Jia (2008), and Tsui, Zhang, Wang, Xin, and Wu (2006) by examining higher education organizational culture and leadership. There is a paucity of research in examining the relationships between university mid-level…

  2. Investigating a Case of Hidden Misinterpretations of an Additive Word Problem: Structural Substitution

    ERIC Educational Resources Information Center

    Polotskaia, Elena; Savard, Annie; Freiman, Viktor

    2016-01-01

    According to numerous studies (Barrouillet & Camos 2002; Brousseau 1988; Chevallard 1988; Riley et al. 1984; Schubauer-Leoni & Ntamakiliro, "Revue Des Sciences de L'éducation," 20(1): 87-113, 1994; Vergnaud 1982; Xin, "The Journal of Educational Research," 100(6):347-360, 2007), a combination of many factors, including…

  3. Investigating a Case of Hidden Misinterpretations of an Additive Word Problem: Structural Substitution

    ERIC Educational Resources Information Center

    Polotskaia, Elena; Savard, Annie; Freiman, Viktor

    2016-01-01

    According to numerous studies (Barrouillet & Camos 2002; Brousseau 1988; Chevallard 1988; Riley et al. 1984; Schubauer-Leoni & Ntamakiliro, "Revue Des Sciences de L'éducation," 20(1): 87-113, 1994; Vergnaud 1982; Xin, "The Journal of Educational Research," 100(6):347-360, 2007), a combination of many factors, including…

  4. Herm Choppers, the Adonia, and Rhetorical Action in Ancient Greece.

    ERIC Educational Resources Information Center

    Fredal, James

    2002-01-01

    Presents a debate between traditionalist ideas from Xin Lin Gale and postmodern ideas from Cheryl Glenn and Susan Jarratt. Quotes Gale who says that you cannot have it both ways, foundational and antifoundational: using the historical evidence to champion Aspasia while at the same time "reclaiming" her from the biases of those very documents.…

  5. The Role of Trop2 Cleavage Products in Prostate Tumorigenesis

    DTIC Science & Technology

    2013-07-01

    Previous studies demonstrating that b-catenin promotes the expansion of prostate spheres (Lukacs et al. 2010; Shahi et al. 2011) led us to test the...ligand-induced proteolytic release of intracellular domain. Nature 393: 382–386. Shahi P, Seethammagari MR, Valdez JM, Xin L, Spencer DM. 2011. Wnt and

  6. Ultrafast Optics: Vector Cavity Laser - Physics and Technology

    DTIC Science & Technology

    2016-06-14

    4142 (1997). 11. D. Y. Tang, J. Guo, Y. F. Song , L. Li, L. M. Zhao, and D. Y. Shen, "GHz pulse train generation in fiber lasers by cavity induced...polarization coupling in a birefringent cavity fiber laser," Opt. Lett. 33, 2317-2319(2008). 21. D. Y. Tang, Y. F. Song , J. Guo, Y. J. Xiang, and D...1051-1053(2005). 28. D. Y. Tang, J. Guo, Y. F. Song , G. D. Shao, L. M. Zhao, and D. Y. Shen, "Temporal cavity soliton formation in an anomalous

  7. ARC-2012-ACD12-0020-002

    NASA Image and Video Library

    2012-02-02

    Shen_Nargis: Snapshot of a very large simulation showing the altitude and velocity of wind speeds within the 2008 Cyclone Nargis. Top wind speeds for the storm were measured at 135 mph. The lowest altitude winds are shown in blue, while the highest altitude winds are shown in pink. Wind speed is shown by color density: higher density denotes stronger winds, slightly transparent color indicates slower wind speeds. Credit: Bryan Green, NASA Ames Research Center; Bo-wen Shen, NASA Goddard Space Flight Center.

  8. EDITORIAL More than a wire More than a wire

    NASA Astrophysics Data System (ADS)

    Demming, Anna

    2010-10-01

    commercial stages, these one-dimensional structures have a number of advantages including the lower melting point of materials at the nanoscale and the potential for further reductions in size and programming current and power requirements. Investigations of one-dimensional structures have provided an enduring stimulant to both fundamental and applied research in nanoscale science and technology research. William Plomer once described creativity as 'the ability to connect the apparently unconnected'. It could perhaps be said that nanowires bring creativity to the ability to connect. References [1] Joachim C, Rousset B, Schonenberger C, Kerrien A, Druet E and Chevalier J 1991 Nanotechnology 2 96 [2] Brandbyge M, Schiotz J, Sorensen M R, Stpltze P, Jacobsen K W and Norskov J K 1995 Phys. Rev. B 52 8499-514 [3] Dai K and Haynie D T 2006 Nanotechnology 17 R14-R25 [4] Snider G S and Williams R S 2007 Nanotechnology 18 035204 [5] Li B, Luo Z, Shi L, Zhou J, Rabenberg L, Ho P S, Allen R A and Cresswell M W 2009 Nanotechnology 20 085304 [6] Liao L, Zhang Z, Yan B, Zheng Z, Bao Q L, Wu T, Li C M, Shen Z X, Zhang J X, Gong H, Li J C and Yu T 2009 Nanotechnology 20 085203 [7] Chung A, Deen J, Lee J-S and Meyyappan M 2010 Nanotechnology 21 412001

  9. Comparative Transcriptomics Reveals Jasmonic Acid-Associated Metabolism Related to Cotton Fiber Initiation

    PubMed Central

    Wang, Liman; Zhu, Youmin; Hu, Wenjing; Zhang, Xueying; Cai, Caiping; Guo, Wangzhen

    2015-01-01

    Analysis of mutants and gene expression patterns provides a powerful approach for investigating genes involved in key stages of plant fiber development. In this study, lintless-fuzzless XinWX and linted-fuzzless XinFLM with a single genetic locus difference for lint were used to identify differentially expressed genes. Scanning electron microscopy showed fiber initiation in XinFLM at 0 days post anthesis (DPA). Fiber transcriptional profiling of the lines at three initiation developmental stages (-1, 0, 1 DPA) was performed using an oligonucleotide microarray. Loop comparisons of the differentially expressed genes within and between the lines was carried out, and functional classification and enrichment analysis showed that gene expression patterns during fiber initiation were heavily associated with hormone metabolism, transcription factor regulation, lipid transport, and asparagine biosynthetic processes, as previously reported. Further, four members of the allene-oxide cyclase (AOC) family that function in jasmonate biosynthesis were parallel up-regulation in fiber initiation, especially at -1 DPA, compared to other tissues and organs in linted-fuzzed TM-1. Real time-quantitative PCR (RT-qPCR) analysis in different fiber mutant lines revealed that AOCs were up-regulated higher at -1 DPA in lintless-fuzzless than that in linted-fuzzless and linted-fuzzed materials, and transcription of the AOCs was increased under jasmonic acid (JA) treatment. Expression analysis of JA biosynthesis-associated genes between XinWX and XinFLM showed that they were up-regulated during fiber initiation in the fuzzless-lintless mutant. Taken together, jasmonic acid-associated metabolism was related to cotton fiber initiation. Parallel up-regulation of AOCs expression may be important for normal fiber initiation development, while overproduction of AOCs might disrupt normal fiber development. PMID:26079621

  10. Metasearch Accuracy for Letters and Symbols: Do Our Intuitions Match Empirical Reality?

    ERIC Educational Resources Information Center

    Green, Sean R.; Redford, Joshua

    2016-01-01

    The "familiarity effect" (Shen and Reingold, "Perception & Psychophysics" 63(3):464-475, 2001) is a phenomenon in which unfamiliar symbols perceptually "pop-out" when placed among familiar symbols (e.g., letters). In contrast, searching for familiar symbols among unfamiliar symbols is more challenging. Failure to…

  11. Molecular Level Understanding of Electrocatalysis in High pH Environment

    DTIC Science & Technology

    2015-07-08

    O2, and OH- radicals.[56-58] The vast majority of research in this domain has focused on the interaction of photons with semiconductor TiO2 largely...Shen! M,! Henderson! MA.! Identification! of! the! active! species! in! photochemical! hole! scavenging! reactions!of!methanol!on! TiO2 .!The!Journal!of

  12. SIMULATION OF OZONE EFFECTS ON EIGHT TREE SPECIES AT SHENANDOAH NATIONAL PARK

    EPA Science Inventory

    As part of an assessment of potential effects of air pollutants on the vegetation of Shenandoah National Park (SHEN), we simulated the growth of eight important tree species using TREGRO, a mechanistic model of individual tree growth. Published TREGRO parameters for black cherry...

  13. Fitting Multidimensional Amotivation into the Self-Determination Theory Nomological Network: Application in School Physical Education

    ERIC Educational Resources Information Center

    Vlachopoulos, Symeon P.; Katartzi, Ermioni S.; Kontou, Maria G.

    2013-01-01

    The present study investigated the nomological validity of the Amotivation Inventory-Physical Education (Shen, Wingert, Li, Sun, & Rukavina, 2010b) scores by examining the associations of ability, effort, value, and task characteristics amotivation beliefs with self-determination theory variables. Data were collected from 401 fifth- and…

  14. Taking Charge of Choice: How Charter School Policy Contexts Matter. Research Brief

    ERIC Educational Resources Information Center

    Smrekar, Claire

    2011-01-01

    Against the backdrop of urban school politics, in which mayors play increasingly powerful and pivotal roles, the current study examines the origins and implications of mayoral control of charter school authorization and accountability in Indianapolis (see Henig & Rich, 2004; Wong & Shen, 2007). In contrast to analyses of mayoral takeovers…

  15. Incremental Syntactic Language Models for Phrase-Based Translation

    DTIC Science & Technology

    2011-06-01

    Cocke and Jacob Schwartz. 1970. Program- ming languages and their compilers. Technical report, Courant Institute of Mathematical Sciences, New York...Federico, Nicola Bertoldi, Brooke Cowan, Wade Shen, Christine Moran, Richard Zens, Chris Dyer, Ondrej Bojar, Alexandra Con- stantin, and Evan Herbst. 2007

  16. Tips from the Classroom.

    ERIC Educational Resources Information Center

    TESOL Journal, 1993

    1993-01-01

    Four short articles are combined: "Adding Discourse-Level Practice to Sentence-Level Exercises" (Eric S. Nelson); "Presenting Picture Books in the ESL Classroom" (Lijun Shen); "Role Playing in a Large Class" (Ellen Rosen); and "Calvin and Hobbes and Other Icons of Americana" (Daniel J. Conrad). (Contains seven references.) (LB)

  17. Adaptive Control of Uncertain Hamiltonian Multi-Input Multi-Output Systems: With Application to Spacecraft Control

    DTIC Science & Technology

    2009-01-01

    Autom. Control, vol. 38, no. 4, pp. 671–672, Apr. 1993. [5] H. Yoon and P. Tsiotras, “Spacecraft adaptive attitude and power tracking with variable speed...Tsiotras, H. Shen, and C. Hall, “Satellite attitude control and power tracking with energy/momentum wheels,” J. Guid., Control, Dyn., vol. 24, no. 1, pp. 23

  18. Productive Figurative Communication: Conventional Metaphors Facilitate the Comprehension of Related Novel Metaphors

    ERIC Educational Resources Information Center

    Thibodeau, Paul; Durgin, Frank H.

    2008-01-01

    Three experiments explored whether conceptual mappings in conventional metaphors are productive, by testing whether the comprehension of novel metaphors was facilitated by first reading conceptually related conventional metaphors. The first experiment, a replication and extension of Keysar et al. [Keysar, B., Shen, Y., Glucksberg, S., Horton, W.…

  19. 76 FR 67764 - Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... COMMISSION Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft...-xxxx, Revision 0, ``Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and... at (301) 492-3446. FOR FURTHER INFORMATION CONTACT: Song-Hua Shen, Division of Risk Analysis,...

  20. SIMULATION OF OZONE EFFECTS ON EIGHT TREE SPECIES AT SHENANDOAH NATIONAL PARK

    EPA Science Inventory

    As part of an assessment of potential effects of air pollutants on the vegetation of Shenandoah National Park (SHEN), we simulated the growth of eight important tree species using TREGRO, a mechanistic model of individual tree growth. Published TREGRO parameters for black cherry...

  1. Writing Prozāk Diaries in Tehran: Generational Anomie and Psychiatric Subjectivities.

    PubMed

    Behrouzan, Orkideh

    2015-09-01

    I explore the historical and cultural shifts that underlie the normalization of the term dépréshen and the emergence of public psychiatric discourses in 1990s Iran. I do this by investigating the cultural sensibilities of a particular generation, the self-identified 1980s generation, and the ways they situate what is perceived as dépréshen in social anomie and the memories of the Iran-Iraq war. I argue that psychiatrization of psychological distress in Iran was not simply a de-politicizing hegemonic biomedical discourse, but that the contemporary Iranian discourses of psychological pathology and social loss evolved in public, hand-in-hand, through the medicalization of post-war loss. Psychiatric subjectivity describes conditions where individuals internalize psychiatry as a mode of thinking, and performatively articulate not only their desires, hopes, and anxieties, but also historical losses as embodied in individual and collective brains. I underscore my interlocutors' simultaneous historicization and medicalization of their dépréshen, arguing that psychiatrically medicalized individuals are performative actors in the discursive formation of both biomedical and social truth. Dépréshen, in the larger sense of the word, has become one way to navigate ruptured pasts, slippery presents, and uncertain futures.

  2. GHz-THz Electronics

    DTIC Science & Technology

    2013-03-07

    Schlom & Kyle Shen (Cornell) Tight coupling of molecular-beam epitaxy (MBE) and angle-resolved photoelectron spectroscopy (ARPES) reveals metal...electronics • Paul Maki – nitride electronics • Chagaan Baatar – 2D materials • Marc Ulrich – topological insulators • Pani Varanasi – 2D materials • Mike

  3. VizieR Online Data Catalog: Abundances of 47 Tuc turn-off stars (Dobrovolskas+, 2014)

    NASA Astrophysics Data System (ADS)

    Dobrovolskas, V.; Kucinskas, A.; Bonifacio, P.; Korotin, S. A.; Steffen, M.; Sbordone, L.; Caffau, E.; Ludwig, H.-G.; Royer, F.; Prakapavicius, D.

    2014-07-01

    Spectra of the TO stars in 47 Tuc investigated in this work were obtained with the GIRAFFE spectrograph in August-September, 2008, under the programme 081.D-0287(A) (PI: Shen). The same data set was independently analysed by D'Orazi et al. (2010ApJ...713L...1D, Cat. J/ApJ/713/L1). (1 data file).

  4. A Study of Effective Teachers' Knowledge and Use of Intersectional Data to Improve Student Academic Performance

    ERIC Educational Resources Information Center

    Williamson, Raychellet

    2012-01-01

    The discussion on how to improve students' academic performance has a long and rich history in the U.S. Although it has been a national priority, the debate has centered on the best method to accomplish this goal. Bernhardt (2003) and Shen and Cooley (2008) recognized the importance of teachers, principals, and data, deployed together, as critical…

  5. Impacts of Ocean Waves on the Atmospheric Surface Layer: Simulations and Observations

    DTIC Science & Technology

    2007-09-30

    Crawford, J. Crescenti, T. Farrar, J. French, N. Frew, G. Gerbi , C. Helmis, T. Hristov, D. Khelif, A. Jessup, H. Jonsson, M. Li, L. Mahrt, W. McGllis...Farrar, J. French, N. Frew, G. Gerbi , C. Helmis, T. Hristov, D. Khelif, A. Jessup, H. Jonsson, M. Li, L. Mahrt, W. McGllis, A. Plueddmann, L. Shen

  6. Lifelong Learning for Social Development: A Review of Global Perspectives. Papers Presented at the International Conference on Lifelong Learning for Social Development (Kerala, India, August 13-15, 2002).

    ERIC Educational Resources Information Center

    2002

    This document contains 67 papers from an international conference on lifelong learning for social development. The following papers are among those included: "Lifelong Learning for Social Development" (John Dewar Wilson); "Building Networks of Lifelong Learning for Social Development outside the Center" (Shen-Tzay Huang, Chi…

  7. Precision Control and Randomized Benchmarking of a 12-us Class Superconducting Qubit

    DTIC Science & Technology

    2013-03-28

    2012 2.00 David Cory, Jonas Bylander, Fei Yan, Simon Gustavsson, Fumiki Yoshihara, Khalil Harrabi, Terry Orlando, Yasunobu Nakamura, Jaw-Shen Tsai...spectroscopy through dynamical decoupling with a superconducting flux qubit” viii. Seminar: Chalmers University of Technology, Gothenburg, Sweden, September

  8. The Role of Vitamin D Stimulation of Mullerian Inhibiting Substance (MIS) in Prostate Cancer Therapy

    DTIC Science & Technology

    2007-12-01

    rickets type II with alopecia . Proc Natl Acad Sci U S A 94:9831-9835 3. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka...rickets without alopecia . Mol Endocrinol 16:2538-2546 40. Shen WH, Moore CC, Ikeda Y, Parker KL, Ingraham HA. 1994 Nuclear receptor steroidogenic

  9. Wave-Ice Interaction in the Marginal Ice Zone: Toward a Wave-Ocean-Ice Coupled Modeling System

    DTIC Science & Technology

    2014-09-30

    generated surface gravity waves (WAVEWATCH III®) such that it can accurately predict the attenuation and scattering of waves by interaction with ice in...generated ocean surface wave models at NCEP. Weather and Forecasting (NCEP Notes), 17, 311-333. Wang, R. and H. H. Shen, 2010: Gravity waves

  10. Roles of Breast Cancer Genes in DNA Homologous Recombination and Cellular Sensitivity to Radiation and Anticancer Drugs

    DTIC Science & Technology

    2000-09-01

    1.2, Juan Huan 2, Zhiyuan Shen 1,3 ’Dept. of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center; 915 Camino de Salud ...915 Camino de Salud , NE Albuquerque, NM 87131 Phone: 505-272-4291 FAX: 505-272-6029 Email zshen()salud.unntLedL. Key words: BRCA2, Calcium-binding

  11. Matter density versus distance for the neutrino beam from Fermilab to Lead, South Dakota, and comparison of oscillations with variable and constant density

    NASA Astrophysics Data System (ADS)

    Roe, Byron

    2017-06-01

    This paper is divided into two parts. In the first part, the material densities passed through for neutrinos going from FNAL to Sanford Laboratory are calculated using two recent density tables, Crustal [G. Laske, G. Masters, Z. Ma, and M. Pasyanos, Update on CRUST1.0—A 1-degree global model of Earth's crust, Geophys. Res. Abstracts 15, EGU2013-2658 (2013),; For the programs and tables, see the website: http://igppweb.ucsd.edu/ gabi/crust1.html.] and Shen-Ritzwoller [W. Shen and M. H. Ritzwoller, Crustal and uppermost mantle structure beneath the United States, J. Geophys. Res.: Solid Earth 121, 4306 (2016)], as well as the values from an older table PEMC [A. M. Dziewonski, A. L. Hales, and E. R. Lapwood, Parametrically simple earth models consistent with geophysical data, Phys. Earth Plan. Int. 10, 12 (1975); For further information see the website: http://ds.iris.edu/ds/products/emc-pem/.]. In the second part, neutrino oscillations at Sanford Laboratory are examined for the variable density table of Shen-Ritzwoller. These results are then compared with oscillation results using the mean density from the Shen-Ritzwoller tables and with one other fixed density. For the tests made here, the mean density results are quite similar to the results using the variable density vs distance.

  12. Provision of Auricular Acupuncture and Acupressure in a University Setting

    ERIC Educational Resources Information Center

    Oyola-Santiago, Tamara; Knopf, Rachel; Robin, Tracy; Harvey, Kristen

    2013-01-01

    Auricular acupuncture using the National Acupuncture Detoxification Association (NADA) protocol stimulates 5 points in each ear--the Shen Men, sympathetic nervous system, liver, kidney, and lung. This protocol is also known as Acu Detox, and has been used for recovery in community-based settings and drug use treatment programs. It has also been…

  13. Multi-Touch Interaction for Robot Command and Control

    DTIC Science & Technology

    2010-12-01

    granularity supported by the Sun JVM on Microsoft Windows XP (Green, 2008). Amplitudes were calculated using the Euclidean distance between the starting...TouchTable. “TouchTable.” Website, 2007. Available online at http://www. touchtable.com (accessed 6 December 2007). E. Tse, C. Shen, S. Greenberg , and

  14. Newspaper coverage of mental illness in Hong Kong between 2002 and 2012: impact of introduction of a new Chinese name of psychosis.

    PubMed

    Chan, Sherry K W; Ching, Elaine Y N; Lam, Kenneth S C; So, Hon-Cheong; Hui, Christy L M; Lee, Edwin H M; Chang, Wing C; Chen, Eric Y H

    2017-08-01

    In Hong Kong, 'si-jue-shi-tiao' () was officially adopted as the Chinese translation of psychosis in 2001. The new term covered a broader aspect of psychosis, compared with the original term, 'jing-shen-fen-lie' (), which gave a negative stereotype as a 'mental split-mind disorder'. The current study compared the usage of the two terms, and added evidence to the name changing as anti-stigma strategy. The usage and themes of the new Chinese name of psychosis 'si-jue-shi-tiao' was examined in 1217 local newspaper articles in comparison with the traditional Chinese name of schizophrenia 'jing-shen-fen-lie'. Results show that an increase use of 'si-jue-shi-tiao' was found equally across themes, whereas 'jing-shen-fen-lie' was decreasingly used in positive/neutral themes over time. The association of 'jing-shen-fen-lie' with dangerous wordings increased over time, but no change was found with the new name. Our finding adds to literature on effects of changing new name on public stigma. © 2015 Wiley Publishing Asia Pty Ltd.

  15. Examining Scientific and Technical Writing Strategies in the 11th Century Chinese Science Book "Brush Talks from Dream Brook"

    ERIC Educational Resources Information Center

    Zhang, Yuejiao

    2013-01-01

    This article examines the influential Chinese science book "Brush Talks from Dream Brook," written by Shen Kuo in the 11th century. I suggest that "Brush Talks" reveals a tension between institutionalized science and science in the public, and a gap between the making of scientific knowledge and the communication of such…

  16. Provision of Auricular Acupuncture and Acupressure in a University Setting

    ERIC Educational Resources Information Center

    Oyola-Santiago, Tamara; Knopf, Rachel; Robin, Tracy; Harvey, Kristen

    2013-01-01

    Auricular acupuncture using the National Acupuncture Detoxification Association (NADA) protocol stimulates 5 points in each ear--the Shen Men, sympathetic nervous system, liver, kidney, and lung. This protocol is also known as Acu Detox, and has been used for recovery in community-based settings and drug use treatment programs. It has also been…

  17. Examining Scientific and Technical Writing Strategies in the 11th Century Chinese Science Book "Brush Talks from Dream Brook"

    ERIC Educational Resources Information Center

    Zhang, Yuejiao

    2013-01-01

    This article examines the influential Chinese science book "Brush Talks from Dream Brook," written by Shen Kuo in the 11th century. I suggest that "Brush Talks" reveals a tension between institutionalized science and science in the public, and a gap between the making of scientific knowledge and the communication of such…

  18. An Integrated Model of Associative and Reinforcement Learning

    DTIC Science & Technology

    2012-08-01

    from robotics (Peters, Vijayakumar, & Schaal, 2003) and artificial intelli- gence (Russell & Norvig , 1995) to cognitive architectures (Fu & Anderson...Crofts. Russell, S. J., & Norvig , P. (1995). Artificial Intelligence: A Modern Approach. Prentice Hall. Shen, J., Reingold, E. M., & Pomplun, M. (2000

  19. Variations of Estuarine Turbid Plumes and Mudflats in Response to Human Activities and Climate Change

    NASA Astrophysics Data System (ADS)

    Doxaran, David; Salama, Suhyb; Yu, Xiaolong; Shen, Fang; Zhou, Yunxuan

    2014-11-01

    Estuarine and coastal waters are referred to as Case 2 waters and much more optically complex because the optical properties of chlorophyll-a (Chla), non-algae particles (NAP), and colored dissolved organic matter (CDOM) and their concentrations are subjected to potentially large and independent variations. As for the Yangtze estuarine and coastal water, its relatively higher concentration of Suspended Particulate Matter (SPM) among world's estuarine and coastal waters provides a reference test site for studying ocean colour algorithms and remote sensing applications in wide-range sediment concentration water and extremely turbid water. Regarding the Dragon 3 project, algorithms for atmosphere correction were improved (Salama and Shen, 2010; Shen and Verhoef, 2010); several novel models to retrieve bio-optical properties, such as concentrations of SPM, Chla and inherent optical properties(IOPs), were also developed for medium and extremely turbid waters, that is the SERT model (Shen et al., 2010), the SCI algorithm (Shen et al., 2010) and the 2SeaColor model (Salama and Verhoef, 2014). Data acquired from both in-situmeasurements and satellite were used for models development and improvement and the results are shown as follows. In general, four aspects of the work have been involved in by the Chinese and European partners by far.

  20. Determination of Transient Skin Temperature of Conical Bodies During Short-Time, High-Speed Flight

    DTIC Science & Technology

    1948-04-06

    technology . ATI documents that are partially legible have been included in the DTIC collection due to their historical value. If you are dissatisfied with...Atmoaphere — Tablea and Data. HACA Rep. Ho. 218, 1925. (Reprint 19*0.) 11. Talen , Haue-Shen: Superaarodynamloa, Mechanics of Rarefied Oases. Jour. Aero. Sei

  1. Metasearch Accuracy for Letters and Symbols: Do Our Intuitions Match Empirical Reality?

    ERIC Educational Resources Information Center

    Green, Sean R.; Redford, Joshua

    2016-01-01

    The "familiarity effect" (Shen and Reingold, "Perception & Psychophysics" 63(3):464-475, 2001) is a phenomenon in which unfamiliar symbols perceptually "pop-out" when placed among familiar symbols (e.g., letters). In contrast, searching for familiar symbols among unfamiliar symbols is more challenging. Failure to…

  2. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (84th, Washington, DC, August 5-8, 2001). Advertising Division.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The Advertising section of the proceedings contains the following 14 selected papers: "Preparing the Entry-level Advertising Portfolio: Pointing Creative Students in the Right Direction" (Sheri J. Broyles); "Effects of Issue Ads on Candidate Evaluation and Voting Preference: Does Sponsorship Matter?" (Fuyuan Shen and H. Denis…

  3. Strategies for Successful Group Work

    ERIC Educational Resources Information Center

    Nipp, Mary Beth; Palenque, Stephanie Maher

    The thought of group work, or CLC Groups often strikes fear and loathing in the hearts and minds of both students and instructors. According to Swan, Shen, and Hiltz (2006) collaborative work presents the possibilities of many difficulties including a largely unequal contribution of group participants, an inability of the students to manage the…

  4. Down-Regulation of Olfactory Receptors in Response to Traumatic Brain Injury Promotes Risk for Alzheimer’s Disease

    DTIC Science & Technology

    2013-10-01

    retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J Mol Biol 342:571-583. Shen MY, Sali A (2006...and the fluorescence intensities were determined using a GCS 3000 7G high-resolution con- focal laser scanner and AGCC software (Affymetrix). The

  5. Highly sensitive and selective determination of fluorine ion by graphene oxide/nanogold resonance Rayleigh scattering-energy transfer analytical platform.

    PubMed

    Liang, Aihui; Peng, Jing; Liu, Qingye; Wen, Guiqing; Lu, Zhujun; Jiang, Zhiliang

    2015-08-15

    In pH 4.0 acetate buffer solution, fluorine ions react with fluorine reagent (FR) and La(III) to generate blue ternary complex that exhibited strong absorption at about 370 nm. Upon addition of graphene oxide/nanogold (GO/NG) as resonance Rayleigh scattering (RRS) spectral probe with strong RRS peak at 370 nm, the color changed to gray, and the RRS intensity decreased with the increase of fluorine ion concentration due to the RRS energy transfer (RRSET) from GO/NG to the complex. Under the selected condition, the decreased RRS peak ΔI370 nm was linear to fluorine ion concentration in the range of 6.0 × 10(-8)-1.3 × 10(-5)mol/L, with a detection limit of 3.0 × 10(-8)mol/L F(-). This RRSET method was applied to the analysis of fluorine in toothpaste and water samples, with satisfactory results.

  6. Subsurface helicity of active regions 12192 and 10486

    NASA Astrophysics Data System (ADS)

    Komm, Rudolf; Tripathy, Sushant; Howe, Rachel; Hill, Frank

    2015-04-01

    The active region 10486 that produced the Halloween flares in 2003 initiated our interest in the kinetic helicity of subsurface flows associated with active regions. This lead to the realization that the helicity of subsurface flows is related to the flare activity of active regions. Eleven years later, a similarly enormous active region (12192) appeared on the solar surface. We plan to study the kinetic helicity of the subsurface flows associated with region 12192 and compare it to that of region 10486. For 10486, we have analyzed Dopplergrams obtained with the Michelson Doppler Imager (MDI) onboard the Solar and Heliospheric Observatory (SOHO) and the Global Oscillation Network Group (GONG) with a dense-pack ring-diagram analysis. For 12192, we have analyzed Dopplergrams from GONG and the Helioseismic and Magnetic Imager (HMI) onboard the Solar Dynamics Observatory (SDO). We will present the latest results.

  7. Measurements of Rotational Frequency Splitting of Low Angular Degree Modes

    NASA Astrophysics Data System (ADS)

    Toutain, Thierry

    2001-05-01

    The rotational splitting of low-degree p modes is still a controversial issue. There are small but nevertheless real discrepancies between the different measurements of splittings obtained with the existing helioseismology experiments from ground (BISON, IRIS, GONG, LOWL) or from space (VIRGO, GOLF, MDI). I review the current status of rotational splitting in the field of low-degree helioseismology and how we could explain the remaining discrepancies between the various sets of splittings.

  8. Study on Locally Confined Deposition of Si Nanocrystals in High-Aspect-Ratio Si Nano-Pillar Array for Nano-Electronic and Nano-Photonic Applications

    DTIC Science & Technology

    2010-02-23

    Final Report for AOARD Grant FA4869-08-1-4011 Title: Study on Locally Confined Deposition of Si Nanocrystals in High-Aspect-Ratio Si Nano ...Pillar Array for Nano -Electronic and Nano -Photonic Applications” Date: Feb. 23, 2010 Name of Principal Investigators: Gong-Ru Lin and Hao-Chung...efficiencies of Si MOSLEDs via the detuning the size and density of high-aspect-ration Si nano -rod and buried Si nanospheres. A rapid thermal annealing

  9. Quantum Entanglement in Optical Lattice Systems

    DTIC Science & Technology

    2015-02-18

    Hamner, Chunlei Qu, Yongping Zhang, JiaJia Chang, Ming Gong, Chuanwei Zhang, Peter Engels. Dicke -type phase transition in a spin-orbit-coupled Bose...coupled BECs, including studies of quench dynamics, Dicke -type physics, and spin-orbit coupled lattice systems. Our experiments were closely accompanied...published as a Rapid Communication in Physical Review A (PRA 88, 021604(R) (2013)). 2.) Dicke -type physics: Following our investigation of

  10. 46 CFR 7.45 - Cape Henlopen, DE to Cape Charles, VA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Inlet Lighted Gong Buoy “1”); thence to Indian River Inlet South Jetty Light. (b) A line drawn from Ocean City Inlet Light “6” to latitude 38°19.4′ N. longitude 75°05.0′ W. (Ocean City Inlet Entrance... Assateague Beach Tower Light to latitude 37°50.2′ N. longitude 75°24.9′ W. (Chincoteague Inlet Lighted...

  11. 46 CFR 7.45 - Cape Henlopen, DE to Cape Charles, VA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Inlet Lighted Gong Buoy “1”); thence to Indian River Inlet South Jetty Light. (b) A line drawn from Ocean City Inlet Light “6” to latitude 38°19.4′ N. longitude 75°05.0′ W. (Ocean City Inlet Entrance... Assateague Beach Tower Light to latitude 37°50.2′ N. longitude 75°24.9′ W. (Chincoteague Inlet Lighted...

  12. 46 CFR 7.45 - Cape Henlopen, DE to Cape Charles, VA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Inlet Lighted Gong Buoy “1”); thence to Indian River Inlet South Jetty Light. (b) A line drawn from Ocean City Inlet Light “6” to latitude 38°19.4′ N. longitude 75°05.0′ W. (Ocean City Inlet Entrance... Assateague Beach Tower Light to latitude 37°50.2′ N. longitude 75°24.9′ W. (Chincoteague Inlet Lighted...

  13. 46 CFR 7.45 - Cape Henlopen, DE to Cape Charles, VA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Inlet Lighted Gong Buoy “1”); thence to Indian River Inlet South Jetty Light. (b) A line drawn from Ocean City Inlet Light “6” to latitude 38°19.4′ N. longitude 75°05.0′ W. (Ocean City Inlet Entrance... Assateague Beach Tower Light to latitude 37°50.2′ N. longitude 75°24.9′ W. (Chincoteague Inlet Lighted...

  14. 46 CFR 7.45 - Cape Henlopen, DE to Cape Charles, VA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Inlet Lighted Gong Buoy “1”); thence to Indian River Inlet South Jetty Light. (b) A line drawn from Ocean City Inlet Light “6” to latitude 38°19.4′ N. longitude 75°05.0′ W. (Ocean City Inlet Entrance... Assateague Beach Tower Light to latitude 37°50.2′ N. longitude 75°24.9′ W. (Chincoteague Inlet Lighted...

  15. Chinese Movements and Social Controls

    DTIC Science & Technology

    2006-06-01

    from challenging the official creed of the state.79 Falun Gong was derived from the practices and beliefs of qigong . Qi describes vital energies...or life forces. Qigong is the set of movements designed to stimulate the flow of qi throughout the body.80 Qigong quickly regained popularity and...ensure compliance with the new policies.89 In December 1990, the celebrated qigong master Zhang Xiangyu was arrested and charged with crimes

  16. The Impact of Changes in State Identity on Alliance Cohesion in Northeast Asia

    DTIC Science & Technology

    2009-12-01

    School, Sun Zhe at Tsinghua University, and Zhan Debin at Fudan University, began to publicly express their new perceptions of the capabilities...Rin 4 al Hong Xuezhi 1 henyang MRC Wang Ke General Kim Hak Sam 994 DDM Kim Jong Kak COGS Choe Kwang General Oh Yong Bang 5 S 1995 MDN DFAB Sun...Qixiang AMS PC Zhang Gong Guangzhou MRPC Shi Yuxia DDM Kim Jong Kak 4 1996 ILD Deputy Director Dai Bingguo North Sea FC Wang Jiying

  17. Solar Origins of Space Weather: Confronting Models with Observations

    DTIC Science & Technology

    2002-09-30

    the Sun (SOLIS) suite of synoptic observing equipment. We are also developing methods to calibrate unique magnetic field data from the world-wide GONG...basis. This allows an Internet user to view the solar magnetic field from any vantage point around the sun and to zoom in on interesting regions using...cases. A major limitation to more extensive testing is uncertainty in linking a specific shock near Earth with a specific event at the sun . Difference

  18. Fire alarm system improvement

    SciTech Connect

    Hodge, S.G.

    1994-10-01

    This document contains the Fire Alarm System Test Procedure for Building 234-5Z, 200-West Area on the Hanford Reservation, Richland, Washington. This Acceptance Test Procedure (ATP) has been prepared to demonstrate that the modifications to the Fire Protection systems function as required by project criteria. The ATP will test the Fire Alarm Control Panels, Flow Alarm Pressure Switch, Heat Detectors, Smoke Detectors, Flow Switches, Manual Pull Stations, and Gong/Door by Pass Switches.

  19. Reducing Structural Weight and Increasing Protection in Simple Structures Subjected to Blast Loads

    DTIC Science & Technology

    2014-08-12

    not display a currently valid OMB control number. 1. REPORT DATE 12 AUG 2014 2. REPORT TYPE Journal Article 3. DATES COVERED 12-08-2014 to 12-08...Vehicle Occupants against Anti-Vehicular Landmine Effects, NATO RTO TECHNICAL REPORT TR-HFM-090, April 2007 2. XZ Zhang, WH Li, XL Gong. The rheology ...Mechanism of shear thickening investigated by a network model, Journal of Non-Newtonian Fluid Mechanics, 1995. 4. MS Hoo Fatt, H Surabhi. Blast

  20. Are Resonant Helioseimic Modes Excited by Solar Flares?

    NASA Astrophysics Data System (ADS)

    Leibacher, John W.; Baudin, Frédéric; Rabello Soares, Maria Cristina

    2016-05-01

    We critically examine reports that flares have been observed to excite resonant p-modes by:-looking in detail at the results of the ring-diagram analysis in terms of duty cycle and center-to-limb variation of ring-diagram power.-applying the same analysis to the Halloween flare using GONG and MDI data.-assessing the stability in terms of oscillation power of both instruments.

  1. The Role of Model Fidelity in Model Predictive Control Based Hazard Avoidance in Unmanned Ground Vehicles Using Lidar Sensors

    DTIC Science & Technology

    2013-03-08

    other factors that can change the maximum steering angle, for example, the slope of the terrain. However, in this study, the vehicle is assumed to move...34 VPH : A New Laser Radar Based Obstacle Avoidance Method for Intelligent Mobile Robots", Proceedings of World Congress on Intelligent Control and...Automation, Hangzhou, China, 5, pp. 4681- 4685. [9] Gong, J., Duan, Y., Man, Y., and Xiong, G., 2007, " VPH +: An Enhanced Vector Polar Histogram Method

  2. Challenges and Opportunities for Ground-based Helioseismic Observations

    NASA Astrophysics Data System (ADS)

    Chaplin, W. J.

    2013-12-01

    I summarize the current status of ground-based helioseismic observations, in particular the two operational networks GONG and BiSON. I then discuss requirements for continued and future ground-based observations based on key science drivers, finishing with a discussion of SPRING, a proposed future high-spatial-resolution network that would provide helioseismic data and a broad range of synoptic data products.

  3. Temporal and spatial analysis of vegetation coverage changes in Ordos area based on time series GIMMS-NDVI data

    NASA Astrophysics Data System (ADS)

    Han, Ruimei; Zou, Youfeng; Ma, Chao; Liu, Pei

    2014-11-01

    Ordos area is the desert-wind erosion desertification steppe transition zone and the complex ecological zone. As the research area, Ordos City has the similar natural geographic environment to ShenDong coalfield. To research its ecological patterns and natural evolution law, it has instructive to reveal temporal and spatial changes of ecological environment with artificial disturbance in western mining. In this paper, a time series of AVHRR-NDVI(Normalized Difference Vegetation Index) data was used to monitor the change of vegetation temporal and spatial dynamics from 1981 to 2006 in Ordos City and ShenDong coalfield, where were as the research area. The MVC (Maximum Value Composites) method, average operation, linear regression, and gradation for NDVI change trend were used to obtained some results, as follows: ¬vegetation coverage had obvious characteristics with periodic change in research area for 26 years, and vegetation growth peak appeared on August, while the lowest appeared on January. The extreme values in Ordos City were 0.2351 and 0.1176, while they were 0.2657 and 0.1272 in ShenDong coalfield. The NDVI value fluctuation was a modest rise trend overall in research area. The extreme values were 0.3071 and 0.1861 in Ordos City, while they were 0.3454 and 0.1904 in ShenDong coalfield. In spatial distribution, slight improvement area and slight degradation area were accounting for 42.49% and 8.37% in Ordos City, while slight improvement area moderate improvement area were accounting for 70.59% and 29.41% in ShenDong coalfield. Above of results indicated there was less vegetation coverage in research area, which reflected the characteristics of fragile natural geographical environment. In addition, vegetation coverage was with a modest rise on the whole, which reflected the natural environment change.

  4. A hydrophobic hole transporting system to improve moisture stability of perovskite solar cells (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Xiao, Lixin

    2016-09-01

    Non-ion additive hole-transporting material (HTM) of hydrophobic oligothiophene derivative named DR3TBDTT and triphenylamine derivative of N,N'-di(3-methylphenyl)-N,N-diphenyl-4,4-diaminobiphenyl (TPD) were used for the organic-inorganic hybrid perovskite solar cells. The power conversion efficiency (PCE) was comparable to the device using Li-TFSI doped spiro-MeOTAD. Moreover, the PCE decreases by only 10% after approximately 1000 h without encapsulation, which suggests an alternative method to improve the stability of perovskite solar cells[1-3 ]. Figure 1. Schematic illustration of the energy diagram of the device without lithium salts REFERENCES [1] Zheng, L.; Ma, Y.; Chu, S.; Wang, S.; Qu, B.; Xiao, L.; Chen, Z.;Gong, Q.; Wu, Z.; Hou, X. Nanoscale 6, 8171-8176 (2014). [2] Zheng Lingling, Chung Yao-Hsien, Ma Yingzhuang, Zhang Lipei, Xiao Lixin, Chen Zhijian, Wang Shufeng, Qu Bo and Gong Qihuang, Chem. Commun. 50, 11196-11199 (2014). [3] Ma Yingzhuang, Chung Yao-Hsien, Zheng Lingling, Zhang Danfei, Yu Xiao, Xiao Lixin, Chen Zhijian, Wang Shufeng, Qu Bo, Gong Qihuang, and Zou Dechun, ACS Appl. Mater. Interfaces 7 (12), 6406-6411 (2015)

  5. Data Assimilation Techniques used in the SOTERIA EC-FP7 Network

    NASA Astrophysics Data System (ADS)

    Lapenta, G.; Bettarini, L.; Skender, M.; Innocenti, M.; Crespon, F.; Skandrani, C.

    2009-12-01

    Currently the state of the art in the operational prediction of the background solar wind speed and the interplanetary magnetic field (IMF) polarity at earth via the so called WSA model (http://www.swpc.noaa.gov/ws/) is based on using an expertly and careful processing of the input data given by solar observations, e.g. the GONG magnetogram synoptic map gong.nso.edu/data/magmap/>s. We investigate here the use of statistical techniques for data assimilation currently widely in use in oceanographic and atmospheric modeling. We base our approach on previous work (Barrero Mendoza, Oscar , Data assimilation in magnetohydrodynamics systems using Kalman filtering , KU Leuven thesis, 2005; Rigler, E.; Arge, C.; Mayer, L., Optimizing Coronal and Solar Wind Model Inputs with Data Assimilation, AGU Fall Meeting 2008) that has already proven the capability. The approach uses multiple runs of the modeling approach on statistically guided modifications of the input (such as the GONG magnetograms). Past observed outputs (such as solar wind speed and IMF obtained from the ACE satellite) can be used to better predict future values. Different statistical approaches will be compared.

  6. Existence of multiple positive solutions for Schrödinger-Poisson systems with critical growth

    NASA Astrophysics Data System (ADS)

    Wang, Jun; Tian, Lixin; Xu, Junxiang; Zhang, Fubao

    2015-10-01

    In this paper, we are concerned with the existence, multiplicity and concentration of positive ground state solutions for the semilinear Schrödinger-Poisson system -\\varepsilon2 Δ u+a(x)u+λφ(x)u=b(x)f(u)+|u|4u,&xin{R}3, -\\varepsilon2 Δφ=u2, uin H1({R}3),&xin{R}3, where {\\varepsilon > 0} is a small parameter, f is a continuous, superlinear and subcritical nonlinearity, and {λ≠0} is a real parameter. Suppose that a( x) has at least one global minimum and b( x) has at least one global maximum. We prove that there are two families of positive solutions for sufficiently small {\\varepsilon > 0}, of which one is concentrating on the set of minimal points of a and the other on the sets of maximal points of b. Moreover, we obtain some sufficient conditions for the nonexistence of positive ground state solutions.

  7. Gullies in Liu Hsin Crater

    NASA Image and Video Library

    2015-01-22

    NASA Mars Reconnaissance Orbiter observes a group of small gullies along a rock layer on the south wall of Liu Hsin Crater. At the foot of the gullies fans of granular sediment have been deposited downhill from the gully formation. Nearby, there are much larger gullies. By comparing the gullies that are just 20 kilometers away, we may be able to determine the factors that affect their size. Liu Hsin (also spelled Xin) was a Chinese astronomer, historian, and editor during the Western Han Dynasty (206 BCE to 9 CE) and then the Xin Dynasty (9 to 23 CE). This caption is based in part on a public target suggestion from HiWish. (Note: the header image is non map-projected, so approximate north is down). http://photojournal.jpl.nasa.gov/catalog/PIA19175

  8. Global solutions to a chemotaxis model with consumption of chemoattractant

    NASA Astrophysics Data System (ADS)

    Wang, Liangchen; Mu, Chunlai; Hu, Xuegang

    2016-08-01

    This paper is devoted to the following chemotaxis system u_t=nabla\\cdot(D(u)nabla u)-nabla\\cdot(S(u)nabla v),quad &xin Ω,quad t>0, v_t=Δ v-uv,quad &xinΩ,quad t>0, under homogeneous Neumann boundary conditions in a smooth bounded domain {Ωsubset {R}^n} ({n≥2}), not necessarily being convex. There are some constants {c_D > 0}, {c_S > 0}, {min{R}} and {qin{R}} such that D(u) ≥ c_D(u+1)^{m-1} quad{and} quad S(u)≤ c_S(u+1)^{q-1}quad for all u≥0. If {q < m+n+2/2n}, it is shown that the model possesses a unique global classical solution which is uniformly bounded; if {q < m/2+n+2/2n}, the global existence of solution is established.

  9. EDITORIAL: Focus on Dilute Magnetic Semiconductors FOCUS ON DILUTE MAGNETIC SEMICONDUCTORS

    NASA Astrophysics Data System (ADS)

    Chambers, Scott A.; Gallagher, Bryan

    2008-05-01

    Chisholm, J D Budai and D P Norton Role of charge carriers for ferromagnetism in cobalt-doped rutile TiO2 T Fukumura, H Toyosaki, K Ueno, M Nakano and M Kawasaki Ab-initio study of exchange constants and electronic structure in diluted magnetic group-IV semiconductors Silvia Picozzi and Marjana Ležaić Phase coherent transport in (Ga,Mn)As D Neumaier, K Wagner, U Wurstbauer, M Reinwald, W Wegscheider and D Weiss Hydrogen interstitials-mediated ferromagnetism in MnxGe1-x magnetic semiconductors Xin-Xin Yao, Shi-Shen Yan, Shu-Jun Hu, Xue-Ling Lin, Chong Han, Yan-Xue Chen, Guo-Lei Liu and Liang-Mo Mei Electronic structures of magnetic semiconductors FeCr2Se4 and Fe0.5Cu0.5Cr2Se4 B I Min, Seung Su Baik, H C Choi, S K Kwon and J-S Kang Investigation of pure and Co2+-doped ZnO quantum dot electronic structures using the density functional theory: choosing the right functional Ekaterina Badaeva, Yong Feng, Daniel R Gamelin and Xiaosong Li Magnetic properties of sol-gel-derived doped ZnO as a potential ferromagnetic semiconductor: a synchrotron-based study N R S Farley, K W Edmonds, A A Freeman, G van der Laan, C R Staddon, D H Gregory and B L Gallagher Local electronic structure of Cr in the II-VI diluted ferromagnetic semiconductor Zn1-xCrxTe M Kobayashi, Y Ishida, J I Hwang, G S Song, A Fujimori, C S Yang, L Lee, H-J Lin, D J Huang, C T Chen, Y Takeda, K Terai, S-I Fujimori, T Okane, Y Saitoh, H Yamagami, K Kobayashi, A Tanaka, H Saito and K Ando Lack of ferromagnetism in n-type cobalt-doped ZnO epitaxial thin films T C Kaspar, T Droubay, S M Heald, P Nachimuthu, C M Wang, V Shutthanandan, C A Johnson, D R Gamelin and S A Chambers XMCD studies on Co and Li doped ZnO magnetic semiconductors Thomas Tietze, Milan Gacic, Gisela Schütz, Gerhard Jakob, Sebastian Brück and Eberhard Goering Ferromagnetic semiconductors and the role of disorder B W Wessels An extensive comparison of anisotropies in MBE grown (Ga,Mn)As material C Gould, S Mark, K Pappert, R G Dengel, J Wenisch, R P

  10. Toughening Mechanism of Double Network Hydrogels

    NASA Astrophysics Data System (ADS)

    Gong, Jian Ping

    2010-03-01

    The fundamental toughening mechanism of DN gels [1] is of great interest to researchers. Extensive experimental and theoretical studies have been performed to explain this mechanism [2-7]. Yielding and necking deformation [2] that was observed through tensile tests and rate-independent hysteresis [3] observed through cyclic loading tests have indicated that DN gels can accumulate internal damage before the suffering macroscopic fracture; after damage accumulation, the DN gels become much softer. We assume that on the microscopic level, yielding is caused by the partial breakage and fragmentation of the brittle first network and interconnection among the fragments by the polymer chains of second network [2]. Brown [4] and Tanaka [5] have proposed similar models that can qualitatively explain the anomalously high fracture energy, assuming that the DN gel is locally damaged (yielded) around the crack tip and that the energy dissipated for damage accumulation enhances the effective fracture energy. Using AFM measurements [6] and 3D color laser microscope[7], we successfully detected the existence of softened regions, of several hundreds μm in thickness, at the crack tip just below the fracture surfaces, which supports the assumption of localized damage accumulation. A linear relationship between the thickness of the softened yielding zone and the fracture energy of the gel was observed, which is in agreement with the local yielding zone explanation. [4pt] [1] Gong, J. P.; Katsuyama, Y.; Kurokawa, T.; Osada, Y. Adv. Mater. 2003, 15, 1155. [0pt] [2] Na Y.H., Tanaka Y., Kawauchi Y., Furukawa H., Sumiyoshi T., Gong J. P., Osada Y., Macromolecules 2006, 39(14), 4641. [0pt] [3] Webber, R. E.; Creton, C.; Brown, H. R.; Gong, J. P. Macromolecules 2007, 40, 2919. [0pt] [4] Brown, H. R. Macromolecules 2007, 40, 3815. [0pt] [5] Tanaka, Y. Euro Phys. Letter. 2007, 78, 56005. [0pt] [6] Tanaka Y.; Kawauchi Y.; Kurokawa T.; Furukawa H.; Okajima T.; Gong J. P. Macrom. Rapid Comm

  11. Rescuing High Avidity T Cells for Prostate Cancer Immunotherapy

    DTIC Science & Technology

    2006-04-01

    lymphoid organs. Eur. J. Immunol. 34:3126-34. (Appendix 1). 2. Xincheng Zheng, Jian-Xin Gao, Xing Chang, Yin Wang , Yan Liu, Jin Wen, Jian Jiang...P. Z., CA69091 and CA58033 to Y. L.), and by the Ohio State University Comprehensive Cancer Center. We thank Dr. Yongjun Liu for helpful discussion... Wang , C., Felio, K., Kantarjian, H. M., Champlin, R. E. and Davis, M. M., Evidence that specific T lymphocytes may participate in the elimination of

  12. Rescuing High Avidity T Cells for Prostate Cancer Immunotherapy

    DTIC Science & Technology

    2005-04-01

    Immunol. (Appendix 1). 2. Xincheng Zheng, Jian-Xin Gao, Xing Chang, Yin Wang , Yan Liu, Jin Wen, Jian Jiang, Yang Liu and Pan Zheng. 2004. B7-CD28...the Ohio State University repertoire of T cells specific for antigens overexpressed in solid Comprehensive Cancer Center. We thank Dr. Yongjun Liu for...tumors. J. Immunol. 2002. 169: 4761-4769. helpful discussion and Ms. Lynde Shaw for editorial 15 Molldrem, J. J., Lee, P. P., Wang , C., Felio, K

  13. A Weighted Difference of Anisotropic and Isotropic Total Variation for Relaxed Mumford-Shah Image Segmentation

    DTIC Science & Technology

    2016-05-01

    A WEIGHTED DIFFERENCE OF ANISOTROPIC AND ISOTROPIC TOTAL VARIATION FOR RELAXED MUMFORD-SHAH IMAGE SEGMENTATION Fredrick Park?† Yifei Lou? Jack Xin...University of California at Irvine, Mathematics Department, Irvine, CA 92697 ABSTRACT We propose to incorporate a weighted difference of anisotropic...Segmentation, Mumford- Shah Functional , Chan-Vese Model, Primal-Dual 1 Introduction The celebrated Mumford and Shah (MS) model [1] in 2-phase form known as the

  14. Temporal Distributional Limit Theorems for Dynamical Systems

    NASA Astrophysics Data System (ADS)

    Dolgopyat, Dmitry; Sarig, Omri

    2017-02-01

    Suppose {T^t} is a Borel flow on a complete separable metric space X, f:X→ R is Borel, and xin X. A temporal distributional limit theorem is a scaling limit for the distributions of the random variables X_T:=int _0^t f(T^s x)ds, where t is chosen randomly uniformly from [0, T], x is fixed, and T→ ∞. We discuss such laws for irrational rotations, Anosov flows, and horocycle flows.

  15. Multiple Instance Fuzzy Inference

    DTIC Science & Technology

    2015-12-02

    Zhang, Xin Chen, and Wei-Bang Chen, “An online multiple instance learn - ing system for semantic image retrieval,” in Multimedia Workshops, 2007. ISMW...INFERENCE A novel fuzzy learning framework that employs fuzzy inference to solve the problem of multiple instance learning (MIL) is presented. The...fuzzy learning framework that employs fuzzy inference to solve the problem of multiple instance learning (MIL) is presented. The framework introduces a

  16. How does the anthropogenic activity affect the spring discharge?

    NASA Astrophysics Data System (ADS)

    Hao, Yonghong; Zhang, Juan; Wang, Jiaojiao; Li, Ruifang; Hao, Pengmei; Zhan, Hongbin

    2016-09-01

    Karst hydrological process has largely been altered by climate change and human activity. In many places throughout the world, human activity (e.g. groundwater pumping and dewatering from mining) has intensified and surpassed climate change, where human activity becomes the primary factor that affects groundwater system. But it is still largely unclear how the human activity affects spring discharge in magnitude and periodicity. This study investigates the effects of anthropogenic activity on spring discharge, using the Xin'an Springs of China as an example. The Xin'an Spring discharge were divided into two time periods: the pre-development period from 1956 to 1971 and the post-development period from 1972 to 2013. We confirm the dividing time (i.e. 1971) of these two periods using the Wilcoxon rank-sum test. Then the wavelet transform and wavelet coherence were used to analyze the karst hydrological processes for the two periods respectively. We analyze the correlations of precipitation and the Xin'an spring discharge with the monsoons including the Indian Summer Monsoon (ISM) and the West North Pacific Monsoon (WNPM) and the climate teleconnections including El Niño Southern Oscillation (ENSO) and Pacific Decadal Oscillation (PDO), respectively. The results indicated that the spring discharge was attenuated about 19.63% under the influence of human activity in the Xin'an Springs basin. However, human activity did not alter the size of the resonance frequencies between the spring discharge and the monsoons. In contrast, it reinforced the periodicities of the monsoons-driven spring discharge. It suggested that human has adapted to the major climate periodicities, and human activity had the same rhyme with the primary climate periodicity. In return, human activity enhances the correlation between the monsoons and the spring discharge.

  17. Modeling Metabolism and Stage-Specific Growth of Plasmodium falciparum HB3 during the Intraerythrocytic Development Cycle

    DTIC Science & Technology

    2014-01-01

    Wallqvist The human malaria parasite Plasmodium falciparum goes through a complex life cycle, including a roughly 48-hour-long intraerythrocytic...disease warrant basic research into the different mechanisms used by Plasmodium falciparum , the most virulent causative agent of malaria , to survive and...metabolism and stage-specific growth of Plasmodium falciparum HB3 during the intraerythrocytic developmental cycle† Xin Fang, Jaques Reifman* and Anders

  18. Scalable Authorization in Role-Based Access Control Using Negative Permissions and Remote Authorization

    DTIC Science & Technology

    2003-01-01

    and Hongjie Xin for making this a rewarding team experience. Thanks to Mr. Michael Warres from Sun Microsystems for being prompt and meticulous in our...Windows NT), and security policies based on the Chinese wall model for separation of duties [8]. RBAC simplifies the administration of access...connection check is sort of a first wall of defense against illegitimate users, while the JavaSpace action is more specific to a particular object, known as

  19. Searching for Exotic Bulk and Interfacial Quantum Phenomena of Perovskite Ruthenates

    DTIC Science & Technology

    2010-03-01

    abstracts): Strong interplay between the lattice and spin degrees of freedom in (Sr1?xCax)3Ru2O7 Jin Peng, Zhe Qu,Bin Qian,David Fobes,Tijiang Liu...Xin, X. Wang , Z.X. Zhou, and J. P. Zheng, “Epitaxial Ca2RuO4+δ thin films grown on (001) LaAlO3 by pulsed laser deposition”, Thin solid Films 515

  20. The exact asymptotic behavior of boundary blow-up solutions to infinity Laplacian equations

    NASA Astrophysics Data System (ADS)

    Wan, Haitao

    2016-08-01

    In this paper, we study the asymptotic behavior of viscosity solutions to boundary blow-up elliptic problem {Δ_{∞}u=b(x)f(u), xinΩ, u|_{partialΩ}=+∞,} where {Ω} is a bounded domain with C 2-boundary in {{R}N}, {bin C(bar{Ω})} is positive in {Ω}, which may be vanishing on the boundary, {fin C1([0, ∞))} is regularly varying or is rapidly varying at infinity.

  1. Multimodal Sensor Fusion for Personnel Detection

    DTIC Science & Technology

    2011-07-01

    Multimodal Sensor Fusion for Personnel Detection Xin Jin Shalabh Gupta Asok Ray Department of Mechanical Engineering The Pennsylvania State...have con- sidered relations taken only two at a time, but we propose to explore relations between higher order cliques as future work. D. Feature...detection,” IEEE Transactions on Pattern Analysis and Machine Intelligence, vol. 23, no. 6, pp. 577–589, 2001. [11] A. Ray , “Symbolic dynamic analysis

  2. Isolation and Growth of Prostate Stem Cells and Establishing Cancer Cell Lines from Human Prostate Tumors

    DTIC Science & Technology

    2009-05-01

    RU, Cheng D, and Witte ON. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A 2006; 29. Cunha GR...Hopkins School of Medicine Flow Sorting Facility) for their expert assistance and Jessica Hicks and Yuko Konishi (Johns Hopkins Department of...P. Mouse urogenital development: a practical approach. Differentiation 2003;71:402–13. 29. Xin L, Ide H, Kim Y, Dubey P, Witte ON. In vivo

  3. Theoretical Studies of Nanoclusters (Briefing Charts)

    DTIC Science & Technology

    2015-07-23

    colloidal stability”, Phys. Chem. Chem. Phys., 14,13194- 13198 (2012). Robert J. Buszek, C. Michael Lindsay, and Jerry A. Boatz, “Tetrakis(nitratoxycarbon...and Potential for Improved Combustibility and Specific Impulse”, ACS Applied Materials and Interfaces, 6,8513-8525 (2014). Robert J. Buszek and Jerry...Emergy, Y. Xin, C. J. Ridge, R. J. Buszek, J. A. Boatz, J. M. Boyle , B. K. Little, and C. M. Lindsay, “Unusual behavior in magnesium- copper cluster

  4. Scalable Automated Model Search

    DTIC Science & Technology

    2014-05-20

    0.5ms. Over the course of hundreds of iterations for hundreds of models, the savings can be substantial. This possibly comes at the expense of...minimization. The computer journal, 7(4):308–313, 1965. [31] K. Ousterhout, A. Panda , J. Rosen, S. Venkataraman, R. Xin, S. Ratnasamy, S. Shenker...and I. Stoica. The case for tiny tasks in compute clusters. [32] B. Panda , J. S. Herbach, S. Basu, and R. J. Bayardo. Planet: massively parallel

  5. Boundedness for a 3D chemotaxis-Stokes system with porous medium diffusion and tensor-valued chemotactic sensitivity

    NASA Astrophysics Data System (ADS)

    Wang, Yilong; Li, Xie

    2017-04-01

    This paper deals with the following chemotaxis-Stokes system n_t+u\\cdot nabla n=Δ n^m-nabla \\cdot (nS(x,n,c)\\cdot nabla c), &{}quad xin Ω , t>0, c_t+u\\cdot nabla c=Δ c-nf(c),&{}quad xin Ω , t>0, u_t=Δ u+nabla P+nnabla φ ,&quad xin Ω , t>0,\\ nabla \\cdot u=0,&{}quad xin Ω , t>0. under no-flux boundary conditions in a bounded domain Ω subset R3 with smooth boundary, where m≥ 1, φ in W^{1,∞}(Ω ), f and S are given functions with values in [0, ∞) and R^{3× 3}, respectively. Here S satisfies |S(x,n,c)|7/6, which insures the global existence of bounded weak solution. Our result covers completely and improves the recent result by Wang and Cao (Discrete Contin Dyn Syst Ser B 20:3235-3254, 2015) which asserts, just in the case m=1, the global existence of solutions, but without boundedness, and that by Winkler (Calc Var Partial Differ Equ 54:3789-3828, 2015) which only involves the case of α =0 and requires the convexity of the domain.

  6. Autonomous Planetary Rover at Carnegie Mellon

    DTIC Science & Technology

    1991-08-01

    which facilitates a circulating gait [5]. David Manko completed * his PhD thesis entitled "A General Model of Legged Locomotion on Natural Terrain" [43...machine to level, and force redistribution of the loads on the feet. The research employed the dynamical models developed by David Manko and a leveling...Delingette, Fabrice Noreils, Bao Xin Wu. Graduate Students: John Bares, Lonnie Chrisman, Richard Goodwin, Goang Tay Hsu, In So Kweon, Long-Ji Lin, David

  7. Adaptive Computation and Modeling for Multiscale Analysis

    DTIC Science & Technology

    2007-11-02

    solution of degree p is the difference between orthogonal polynomials of degrees p and p + 1. In one dimension, the orthogonal polynomials are Radau ...muzzle blast - A validation case study", 41st AIAA Aerospace Sciences Meeting and Exhibit, Jan. 2003. [3] Chevaugeon, N., Hu, P ., Li, X., Xin, J., Cler, D... P ., Flaherty, J.E. and Shephard, M.S., "Solving Fluid/Rigid body Interaction Problem by a Discontinuous Galerkin Level Set Method", in preparation

  8. Development and Testing of Advanced EM Accelerator Bore Materials

    DTIC Science & Technology

    1992-02-01

    copper ( Glidcop Al -15) conductor rails when using the ceramic insulators, a phenoimen(n that they plan t•o iivestigate further. Sone of the I• Xin. (46...DESIGNS AND BORE ENVIRONMENTS .................... 25 4.0 ANALYTICAL MODELING TO DEFINE PROPERTY REQUIREMENTS...Advanced Ceramic Insulator AIN-0.4Y 20 3 - 25 v/o SiC ..’............................................ 65 5.7 Cutting Map for Ceramic Plates, Type 1

  9. Alluvial Fan, China

    NASA Image and Video Library

    2017-09-27

    Image taken 5/2/2002 by ASTER: A vast alluvial fan blossoms across the desolate landscape between the Kunlun and Altun mountain ranges that form the southern border of the Taklimakan Desert in China's XinJiang Province. This image can be found on ASTER Path 143 Row 34, center: 37.43 N, 84.30 E. To learn more about the Landsat satellite go to: landsat.gsfc.nasa.gov/

  10. [Textual research on herb youba].

    PubMed

    Xie, Z

    1998-02-01

    A textual research has been conducted to clarify the botanical origin of the herb Youba in ancient medicinal literatures. The name Youba in (Xin Xiu Ben Cao) published in the Tang dynasty and (Ben Cao Gang Mu) published in the Ming dynasty has been confirmed to be the immature tuber of Pinellia pedatisecta (without branches around the tuber), whereas the same name Youba in (Zhi Wu Ming Shi Tu Kao) published in the Qing dynasty refers to Arisaema yunnanense.

  11. The Mechanism of E2F/P130 Mediated Repression and Its Potential Tumor Suppressor Function in Breast Cancer

    DTIC Science & Technology

    2000-07-01

    of genes that are necessary for a cell cycle progression into S phase. During times of cellular quiescence when expression of S phase genes would be...CtBP corepressor" was presented at the Keystone Symposia, Cancer, Cell Cycle and Therapeutics in January of 2000. 9 Conclusions As described by the...retinoblastoma- binding protein. Genomics 51, 351-358 (1998). 7. Xin, Y., and Baer, R. Nuclear localization and cell cycle -specific expression of CtIP, a

  12. Existence of nontrivial solution for Schrödinger-Poisson systems with indefinite steep potential well

    NASA Astrophysics Data System (ADS)

    Sun, Juntao; Wu, Tsung-Fang; Wu, Yuanze

    2017-06-01

    In this paper, we study a class of nonlinear Schrödinger-Poisson systems with indefinite steep potential well: -Δ u+V_{λ }(x)u+K(x)φ u=|u|^{p-2}u in R3, -Δ φ =K( x) u2 in R3, where 30 and K(x)≥ 0 for all x\\in R3. We require that a\\in C( R3) is nonnegative and has a potential well Ω a, namely a(x)≡ 0 for x\\in Ω a and a(x)>0 for x\\in R3\\setminus \\overline{Ω a}. Unlike most other papers on this problem, we allow that b\\in C(R3) is unbounded below and sign-changing. By introducing some new hypotheses on the potentials and applying the method of penalized functions, we obtain the existence of nontrivial solutions for λ sufficiently large. Furthermore, the concentration behavior of the nontrivial solution is also described as λ → ∞.

  13. Scientific psychology within the Chinese language and cultural context.

    PubMed

    Shen, Heyong

    2006-01-01

    The Scientific Psychology that was founded by Wilhelm Wundt appeared in China in the late nineteenth century. The scholars translated the name of psychology into Chinese as Xin-Li-Xue, for which the meaning of the words looks like "heartology," i.e., "the study of the heart." In Chinese, the same core structure related to "heart" (Xin) is found in most of the terms of psychology, such as emotion, thinking, will, forgetting, and memory. By translating Xin as "heart" instead of "mind," we maintain an embodied approach to understanding the "principles of the heart." Through a historical approach to the influence of Western psychology, a cultural analysis of the meaning of the term psychology in Chinese, and a focus on the meeting of Eastern and Western psychology, we can witness the significance of psychology in the Chinese language and cultural context. I will use three parts to present psychology in the Chinese cultural context: the origins of Chinese psychology, from a historical approach; the meaning of "psychology" in Chinese, using a cultural analysis; and the meeting of Eastern and Western psychology, focusing on the development and future.

  14. Global existence and boundedness in a higher-dimensional quasilinear chemotaxis system

    NASA Astrophysics Data System (ADS)

    Wang, Yilong; Xiang, Zhaoyin

    2015-12-01

    This paper deals with the boundedness of global solutions to the quasilinear Keller-Segel system u_t=nabla\\cdotbig(D(u)nabla u-unabla vbig), &quad xinΩ, t>0, v_t=Δ v-uf(v),&quad xinΩ, t>0, nabla u\\cdot ν=0, nabla v\\cdotν=0,&quad xin partialΩ, t>0 in a bounded domain {Ωsubset Rn(n≥ 3)} with smooth boundary, where D( u) is supposed to satisfy D( u) ≥ D 0 u m-1 with some positive constant D 0. It is proved that when {m>2-n+2/2n}, the system possesses global bounded weak solutions for any sufficiently smooth nonnegative initial data. In particular, we improved the recent result by Wang et al. (Z Angew Math Phys, 2015. doi: 10.1007/s00033-014-0491-9 ) in the sense that we established the global boundedness of weak solutions. We also removed the convexity assumption on the domain used by Wang et al. (Z Angew Math Phys 65:1137-1152, 2014, 2015).

  15. Rectangular computed tomography using a stationary array of CNT emitters: initial experimental results

    NASA Astrophysics Data System (ADS)

    Gonzales, Brian; Spronk, Derrek; Cheng, Yuan; Zhang, Zheng; Pan, Xiaochuan; Beckmann, Moritz; Zhou, Otto; Lu, Jianping

    2013-03-01

    XinRay Systems Inc has a rectangular x-ray computed tomography (CT) imaging setup using multibeam x-ray tubes. These multibeam x-ray tubes are based on cold cathodes using carbon nanotube (CNT) field emitters. Due to their unique design, a CNT x-ray tube can contain a dense array of independently controlled electron emitters which generate a linear array of x-ray focal spots. XinRay uses a set of linear CNT x-ray tubes to design and construct a stationary CT setup which achieves sufficient CT coverage from a fixed set of views. The CT system has no moving gantry, enabling it to be enclosed in a compact rectangular tunnel. The fixed locations of the x-ray focal spots were optimized through simulations. The rectangular shape creates significant variation in path length from the focal spots to the detector for different x-ray views. The shape also results in unequal x-ray coverage in the imaged space. We discuss the impact of this variation on the reconstruction. XinRay uses an iterative reconstruction algorithm to account for this unique geometry, which is implemented on a graphics processing unit (GPU). The fixed focal spots prohibit the use of an antiscatter grid. Quantitative measure of the scatter and its impact on the reconstruction will be discussed. These results represent the first known implementation of a completely stationary CT setup using CNT x-ray emitter arrays.

  16. An oral versus intranasal prime/boost regimen using attenuated human rotavirus or VP2 and VP6 virus-like particles with immunostimulating complexes influences protection and antibody-secreting cell responses to rotavirus in a neonatal gnotobiotic pig model.

    PubMed

    Azevedo, Marli S P; Gonzalez, Ana Maria; Yuan, Lijuan; Jeong, Kwang-Il; Iosef, Cristiana; Van Nguyen, Trang; Lovgren-Bengtsson, Karin; Morein, Bror; Saif, Linda J

    2010-03-01

    We determined the impact of mucosal prime/boost regimens and vaccine type (attenuated Wa human rotavirus [AttHRV] or nonreplicating Wa 2/6 rotavirus-like particles [VLP]) on protection and antibody-secreting cell (ASC) responses to HRV in a neonatal gnotobiotic pig disease model. Comparisons of delivery routes for AttHRV and evaluation of nonreplicating VLP vaccines are important as alternative vaccine approaches to overcome risks associated with live oral vaccines. Groups of neonatal gnotobiotic pigs were vaccinated using combinations of oral (PO) and intranasal (IN) inoculation routes as follows: (i) 3 oral doses of AttHRV (AttHRV3xPO); (ii) AttHRV3xIN; (iii) AttHRVPO, then 2/6VLP2xIN; (iv) AttHRVIN, then 2/6VLP2xIN; and (v) mock-inoculated controls. Subsets of pigs from each group were challenged with virulent Wa HRV [P1A(8) G1] (4 weeks post-primary inoculation) to assess protection. The AttHRVPO+2/6VLP2xIN pigs had the highest protection rates against virus shedding and diarrhea (71% each); however, these rates did not differ statistically among the vaccine groups, except for the AttHRVIN+2/6VLPIN group, which had a significantly lower protection rate (17%) against diarrhea. The isotype, magnitude, and tissue distribution of ASCs were analyzed by enzyme-linked immunospot assay. The highest mean numbers of virus-specific IgG and IgA ASCs were observed pre- and postchallenge in both intestinal and systemic lymphoid tissues of the AttHRVPO+2/6VLPIN group. Thus, the AttHRVPO+2/6VLPIN vaccine regimen using immunostimulating complexes (ISCOM) and multiple mucosal inductive sites, followed by AttHRV3xPO or IN regimens, were the most effective vaccine regimens, suggesting that either AttHRVPO+2/6VLPIN or AttHRV3xIN may be an alternative approach to AttHRV3xPO for inducing protective immunity against rotavirus diarrhea.

  17. Predicting protein subcellular locations with feature selection and analysis.

    PubMed

    Cai, Yudong; He, Jianfeng; Li, Xinlei; Feng, Kaiyan; Lu, Lin; Feng, Kairui; Kong, Xiangyin; Lu, Wencong

    2010-04-01

    In this paper, we propose a strategy to predict the subcellular locations of proteins by combining various feature selection methods. Firstly, proteins are coded by amino-acid composition and physicochemical properties, then these features are arranged by Minimum Redundancy Maximum Relevance method and further filtered by feature selection procedure. Nearest Neighbor Algorithm is used as a prediction model to predict the protein subcellular locations, and gains a correct prediction rate of 70.63%, evaluated by Jackknife cross-validation. Results of feature selection also enable us to identify the most important protein properties. The prediction software is available for public access on the website http://chemdata.shu.edu.cn/sub22/, which may play a important complementary role to a series of web-server predictors summarized recently in a review by Chou and Shen (Chou, K.C., Shen, H.B. Natural Science, 2009, 2, 63-92, http://www.scirp.org/journal/NS/).

  18. [A discussion on influence of philosophical idea of Guan Zi on TCM].

    PubMed

    Bao, Xiao-Dong

    2004-04-01

    Guan Zi has substantial content and deep idea, being paid great attention among the various ancient schools of thought. After discussing the influence of its philosophical idea on TCM, it can be concluded that Guan Zi raised Yin Yan concept to a natural law earlier after Lao Zi first philosophized it. Meanwhile discussed the relationship between Yin and Yang systematically such as respecting Yang, Yang can control Yin, and relativity of Yin and Yang. It first setup Jing -Qi Theory, discussing materiality of the Nature and life from the sense of ontology. But it confused Jing Shen and Jing Qi, and could not weep the primitive color of Xing-Shen Monism. It emphasized on self-cultivation and embodied Xu (voidness), Yi (unity), Jing (tranquility) and Yin (cause) on preserving health.

  19. [Dialectic research on "shu pu" (referring a symptom) and "shu pu" (referring a place)].

    PubMed

    Wang, Z

    2001-01-01

    The name of "shu pu" come from Shen shi fang (Prescriptions of Master Shen), which was quoted by Wai tai mi yao (Medical Secrets of an Official), compiled by Wang Tao of the Tang dynasty. In the successive processes of Zheng lei ben cao (Classified Materia Medica) and Ben cao gang mu (Compendium of Materia Medica), it was mixed up with "shu pu", a symptom, in Su wen ci jin lun (On Banning of Acupuncture in Plain Questions), and "shu pu", a place, in Zhen jiu jia yi jing (A -- B Classin of Acupuncture and Moxibustion). In fact, "shu pu" was the meat of rats with no processing, which can be used externally or administered orally to treat injury due to metallic tools and abscess.

  20. Uniform regularity estimates in homogenization theory of elliptic systems with lower order terms on the Neumann boundary problem

    NASA Astrophysics Data System (ADS)

    Xu, Qiang

    2016-10-01

    In this paper, we mainly employed the idea of the previous paper [34] to study the sharp uniform W 1 , p estimates with 1 < p ≤ ∞ for more general elliptic systems with the Neumann boundary condition on a bounded C 1 , η domain, arising in homogenization theory. Based on the skills developed by Z. Shen in [27] and by T. Suslina in [31,32], we also established the L2 convergence rates on a bounded C 1 , 1 domain and a Lipschitz domain, respectively. Here we found a ;rough; version of the first order correctors (see (1.12)), which can unify the proof in [27] and [32]. It allows us to skip the corresponding convergence results on Rd that are the preconditions in [31,32]. Our results can be regarded as an extension of [23] developed by C. Kenig, F. Lin, Z. Shen, as well as of [32] investigated by T. Suslina.

  1. In Vivo Testing of Chemopreventive Agents Using the Dog Model of Spontaneous Prostate Carcinogenesis

    DTIC Science & Technology

    2001-03-01

    FUNDING NUMBERS In Vivo Testing of Chemopreventive Agents Using the Dog Model of Spontaneous DAMD1 7-98-1-8550 Prostate Carcinogenesis 6. AUTHOR( S ... castration (n= 9 dogs ). Interventions were well tolerated by all dogs . Although the final data analysis is not yet completed, our project has generated...Waters DJ, Shen S , Glickman LT. Life expectancy, antagonistic pleiotropy, and the testis of dogs and men. Prostate 2000;43:272-277. DNA damage-sparing

  2. Symposium on Nano- and Micro-Scale Mechanics of Engineering Materials

    DTIC Science & Technology

    2007-04-30

    04-30-2007 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Symposium on Nano - and Micro -scale Mechanics of Engineering N00014-06-1-0900 Materials 5b...mechanical characterization at the nano - and micro -scales. The basic venue of the symposium is on a mixture of keynote addresses and short lectures given by...Rev. 8/98) Final Report Symposium on Nano - and Micro -scale Mechanics of Engineering Materials Principal Investigator: Prof Yu-Lin Shen (Point of

  3. Diffraction Theory for Polygonal Apertures

    DTIC Science & Technology

    1988-07-01

    Institute of Optics, for providing a fertile environment for growth and learning. Thank you, Scott, Maddy, Rob, Keith, Paul, Tom, Shen-ge, Lyle, Dennis ...completeness. The Gabor 15 (1946) representation was introduced within the context of communication theory. After proving that a signal’s specificity...information), Gabor found a general family of signals that achieve the theoretical lower limit of joint uncertainty in time and frequency. These

  4. Towards SDS (Strategic Defense System) Testing and Evaluation: A collection of Relevant Topics

    DTIC Science & Technology

    1989-07-01

    103 Victor R. Basill SM ichael Evangelist...Computer Society Press. [Fran85 Frankl , P.G., S.N. Weiss, and E.J. Weyuker. 1985. "ASSET: A System To Select and Evalu- ate Tests." In Proceedings IEEE...Shen 99 SDIO Workshop Position Paper Victor R. Basili Department of Computer Science University of Maryland I. CriticalGaps A. Evaluation Technology

  5. Anisotropic x-ray anomalous diffraction and forbidden reflections

    SciTech Connect

    Carra, P.; Thole, B.T. )

    1994-10-01

    In this paper the authors present a general analysis of resonant elastic scattering of x rays. The approach exploits crystal symmetry, scattering geometry, and polarization. Extinction rules, their breaking, and the observation of forbidden reflections are discussed. As an application, a detailed description of the experiment performed by Finkelstein, Shen, and Shastri at the iron [ital K] edge in [alpha] Fe[sub 2]O[sub 3] (hematite) is reported.

  6. Temporal Evolution of Non-equilibrium Gamma’ Precipitates in a Rapidly Quenched Nickel Base Superalloy (Preprint)

    DTIC Science & Technology

    2014-04-01

    González-Carrasco, Phase separation in PM 2000™ Fe-base ODS alloy: Experimental study at the atomic level, Materials Science and Engineering: A. 490 (2008... Simmons , Y. Wang, M. Mills, Formation of multimodal size distributions of γ′ in a nickel-base superalloy during interrupted continuous cooling, Scr...diffraction method, Materials Science and Engineering: A. 528 (2010) 32-36. [28] Y. Wen, J. Simmons , C. Shen, C. Woodward, Y. Wang, Phase-field modeling of

  7. Role of the EGF-Related Growth Factor cripto in Murine Mammary Tumorigenesis

    DTIC Science & Technology

    2000-10-01

    activities of EGF-CFC proteins through analysis of knock-out mice for Cripto and Cryptic (reviewed in (Shen and Schier, 2000); see appendix). We have...Generation and analysis of Cripto transgenic mice Rationale: To investigate the effects of Cripto on mammary development and oncogenesis, we...phenotype at different stages of mammary development, thereby accomplishing tasks 1-5 of our Statement of Work. Analysis of whole-mounts of mammary fat pads

  8. Sea State and Boundary Layer Physics of the Emerging Arctic Ocean

    DTIC Science & Technology

    2013-09-01

    theory of wave attenuation/scattering in the sea ice cover • Apply wave–ice interactions directly in integrated arctic system models • Understand heat...2011a; Williams et al., 2013a,b) offers significant promise in this context. There are several different theories for wave–ice interactions. Rogers...et al. (2011) suggests four classes for such theories : viscous (e.g., Newyear and Martin, 1999); viscoelastic (e.g., Wang and Shen, 2010); turbulent

  9. USSS-MITLL 2010 Human Assisted Speaker Recognition

    DTIC Science & Technology

    2010-10-25

    lihl ~ liyl lehl-7lihl *O=s* -7 *O=sh* I # *0* t r (tier: reduct;,On) *O=ao* -7 *O=oh* *0=1* -7 *0=0* I [+ vowel ] *0* . .. (many more rules; trial...IlIlerspeech. Antwerp, 27 Aug 2007. [8] R. Schwartz. \\Y. Shen, J. Campbell , R. Granvill e. "Measuring Typicality of Speech Features in American English

  10. Boundary Korn Inequality and Neumann Problems in Homogenization of Systems of Elasticity

    NASA Astrophysics Data System (ADS)

    Geng, Jun; Shen, Zhongwei; Song, Liang

    2017-06-01

    This paper is concerned with a family of elliptic systems of linear elasticity with rapidly oscillating periodic coefficients, arising in the theory of homogenization. We establish uniform optimal regularity estimates for solutions of Neumann problems in a bounded Lipschitz domain with L 2 boundary data. The proof relies on a boundary Korn inequality for solutions of systems of linear elasticity and uses a large-scale Rellich estimate obtained in Shen (Anal PDE, arXiv:1505.00694v2).

  11. Channel Modelling and Performance of Non-Line-of-Sight Ultraviolet Scattering Communications

    DTIC Science & Technology

    2012-01-01

    Liu, H., Campbell, J.C.: ‘Ultraviolet single photon detection with Geiger - mode 4H-SiC avalanche photodiodes ’, IEEE Photonics Technol. Lett., 2007, 19... Avalanche photodiode (APD) detectors are also rapidly being developed [6, 7]. These device advances have inspired recent research in LED-based short...22), pp. 1822–1824 7 Shen, S.C., Zhang, Y., Yoo, D., et al.: ‘Performance of deep ultraviolet GaN avalanche photodiodes grown by MOCVD’, IEEE

  12. Purinergic Receptors in Quiescence and Localization of Leukemic Stem Cells

    DTIC Science & Technology

    2013-05-01

    Reportable Outcomes Cho JS, Shen H, Hui Y, Cheng T, Lee SB, Lee BC. 2011. Ewing’s Sarcoma Gene EWS regulates Hematopoietic Stem Cell Senescence...Distribution Unlimited The views, opinions and/or findings contained in this report are those of the author( s ...Leukemic Stem Cells 5b. GRANT NUMBER W81XWH-09-1-0364 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Byeong-Chel Lee Betty Diamond 5d. PROJECT

  13. A Language-Independent Approach to Automatic Text Difficulty Assessment for Second-Language Learners

    DTIC Science & Technology

    2013-08-01

    Learners Wade Shen1, Jennifer Williams1, Tamas Marius2, and Elizabeth Salesky †1 1MIT Lincoln Laboratory Human Language Technology Group, 244 Wood Street... English , and Pashto. We compare Support Vector Machines and the Margin-Infused Relaxed Algorithm measured by mean squared er- ror. We provide an analysis of...level is an obstacle for second-language learners and educators alike. With the growth of publicly available Internet and news sources, learners and

  14. State of the Art and Future Trends in the Development of Thermal Barrier Coating Systems

    DTIC Science & Technology

    2006-05-01

    structure is similar to the fluorite structure assumed by YSZ but with one missing oxygen atom, and a large number of displaced oxygen atoms. As such...the pyrochlore crystal can be considered as an ordered, highly defective fluorite solid solution with reduced symmetry and more complicated structure...with the fluorite and pyrochlore structure”, Solid State Ionics, 9-10, 1983, 913-20. [36] Mori, M., Abe, T., Itoh, H., Yamamoto, O., Shen, G. Q

  15. Robust Modeling of Complex Systems with Heavy Tails and Long Memory

    DTIC Science & Technology

    2014-07-16

    dimensional random walk in a random environment, Annals de L’Institut d’Henri Poincare (09 2011) Gennady Samorodnitsky, Tilo Nguyen. Tail Inference: where...2 PERCENT_SUPPORTEDNAME FTE Equivalent: Total Number: NAME Total Number: NAME Total Number: Tilo Nguyen Yi Shen Takashi Owada Luis Lopez-Oliveros...simultaneous asymptotic regimes coexist in one problem. In real data they must be diagnosed and used to advantage. 8. Tilo Nguyen studied the issue

  16. A New Computational Methodology for Structural Dynamics Problems

    DTIC Science & Technology

    2008-04-01

    of thermal loading and uniform pressure on the bending response of FGM plates; and Yang and Shen (2003a,b), who analyzed the nonlinear bending and...deflection bending and thermal postbuckling of FGM circular plates subjected to mechanical and thermal loading. Both articles are based on the classical...on the FSDT. Thermomechanical buckling, as well as bending and free vibration analysis, of FGM plates can be found in the articles by Reddy and

  17. Using the Homotopy Method to Find Periodic Solutions of Forced Nonlinear Differential Equations

    ERIC Educational Resources Information Center

    Fay, Temple H.; Lott, P. Aaron

    2002-01-01

    This paper discusses a result of Li and Shen which proves the existence of a unique periodic solution for the differential equation x[dots above] + kx[dot above] + g(x,t) = [epsilon](t) where k is a constant; g is continuous, continuously differentiable with respect to x , and is periodic of period P in the variable t; [epsilon](t) is continuous…

  18. A Comparison of the Theoretical Relationship between HDL Size and the Ratio of HDL Cholesterol to Apolipoprotein A-I with Experimental Results from the Women’s Health Study

    PubMed Central

    Mazer, Norman A.; Giulianini, Franco; Paynter, Nina P.; Jordan, Paul; Mora, Samia

    2013-01-01

    Background HDL size and composition vary among individuals and may be associated with cardiovascular disease and diabetes. We investigated the theoretical relationship between HDL size and composition using an updated version of the spherical model of lipoprotein structure proposed by Shen et al. and compared its predictions with experimental data from the Women’s Health Study (WHS). Methods The Shen model was updated to predict the relationship between HDL diameter and the ratio of HDL-cholesterol (HDL-C) to apolipoprotein A-I (ApoA-I) plasma concentrations, i.e., the HDL-C/ApoA-I ratio. In WHS (n=26,772), NMR spectroscopy was used to measure the average HDL diameter (davg,NMR) and particle concentration (HDL-P); HDL-C and ApoA-I (mg/dL) were measured by standardized assays. Results The updated Shen model predicts a quasi-linear increase of HDL diameter with the HDL-C/ApoA-I ratio, consistent with the measured davg,NMR values from WHS, which ranged between 8.0 and 10.8 nm and correlated positively with the HDL-C/ApoA-I ratio (r=0.608, p<2.2×10−16). The WHS data were further described by a linear regression equation: dWHS (nm) = 4.66 + 12.31 HDL-C/ApoA-I. The validity of this equation for estimating HDL size was assessed with data from CETP deficiency and pharmacologic inhibition. We also illustrate how HDL-P can be estimated from the HDL size and ApoA-I level. Conclusions This study provides a large-scale experimental examination of the updated Shen model, offers new insights into HDL structure, composition and remodeling, and suggests that the HDL-C/ApoA-I ratio could be a readily available biomarker for estimating HDL size and HDL-P. PMID:23426429

  19. Origin and Characteristics of High Shannon Entropy at the Pivot of Locally Stable Rotors: Insights from Computational Simulation

    PubMed Central

    Gharaviri, Ali; Brooks, Anthony; Chapman, Darius; Lau, Dennis H.; Roberts-Thomson, Kurt C.; Sanders, Prashanthan

    2014-01-01

    Background Rotors are postulated to maintain cardiac fibrillation. Despite the importance of bipolar electrograms in clinical electrophysiology, few data exist on the properties of bipolar electrograms at rotor sites. The pivot of a spiral wave is characterized by relative uncertainty of wavefront propagation direction compared to the periphery. The bipolar electrograms used in electrophysiology recording encode information on both direction and timing of approaching wavefronts. Objective To test the hypothesis that bipolar electrograms from the pivot of rotors have higher Shannon entropy (ShEn) than electrograms recorded at the periphery due to the spatial dynamics of spiral waves. Methods and Results We studied spiral wave propagation in 2-dimensional sheets constructed using a simple cell automaton (FitzHugh-Nagumo), atrial (Courtemanche-Ramirez-Nattel) and ventricular (Luo-Rudy) myocyte cell models and in a geometric model spiral wave. In each system, bipolar electrogram recordings were simulated, and Shannon entropy maps constructed as a measure of electrogram information content. ShEn was consistently highest in the pivoting region associated with the phase singularity of the spiral wave. This property was consistently preserved across; (i) variation of model system (ii) alterations in bipolar electrode spacing, (iii) alternative bipolar electrode orientation (iv) bipolar electrogram filtering and (v) in the presence of rotor meander. Directional activation plots demonstrated that the origin of high ShEn at the pivot was the directional diversity of wavefront propagation observed in this location. Conclusions The pivot of the rotor is consistently associated with high Shannon entropy of bipolar electrograms despite differences in action potential model, bipolar electrode spacing, signal filtering and rotor meander. Maximum ShEn is co-located with the pivot for rotors observed in the bipolar electrogram recording mode, and may be an intrinsic property of

  20. Molecular Genetic Study of Human Esophageal Carcinoma

    DTIC Science & Technology

    1991-07-16

    proliferation. Some DNA tumor virus have been shown to be the causative agent for human cancer, as human papilloma - virus (HPV) was associated with...genital tumors. Gene products, such as SV40 tumor antigen, Ela and Elb in adenovirus, E6 and E7 protein of human papilloma virus type 16 and type 18...F.J., Syrjanen, S., Shen, Q., J.I, H., & Kyrjanen, K. Human papilloma virus (HPV) DNA in esophageal precursor lesions and squamous cell carcinomas

  1. Temperature Dependent Spectral Response and Detectivity of GeSn Photoconductors on Silicon for Short Wave Infrared Detection

    DTIC Science & Technology

    2014-01-01

    the thickness is much smaller than the skin depth , , then Eq. (1) reduces to, (2) where C is a constant independent of...P. Guo, H. Hu, Z. Shen, G. Han, and Y.-C. Yeo, "Relaxed and Strained Patterned Germanium-Tin Structures: A Raman Scattering Study," ECS J. of Solid...then rinsed in DI water . Following this resist removal, the samples were loaded into a plasma enhanced chemical vapor deposition (PECVD) reactor

  2. Breast Tumor pH: Design, Evaluation, and Application of Novel Reporter Molecules

    DTIC Science & Technology

    2001-10-01

    additional NMR resonances, which we attribute to a second molecular conformation (eis vs . trans.). While this indicator may not be ideal, it could be...Secondary Hydroxyl Group in Monosaccharides and Synthesis of Some Branched Monosaccharides ". Undergraduate student in Department of Chemistry, Xinjiang...Dong, Meng-shen Cai, Syntheses of Disaccharides Corresponding to the Repeat Unit of the Polysaccharide with Antitumor Effects from

  3. Technology Base Seminar Wargame II (TBSWG II). Volume 3. TBSWG II process Description (Appendices F-I)

    DTIC Science & Technology

    1990-11-20

    Dennis R. Schmidt Bruce M. Fonoroff Edward Panuska Kleber S. Masterson, Jr. John R. Statz, Jr. Raymond A. Haeme Mark Herman Robert J. Ryer Booz *Allen...Dr. William McCorkle (MICOM) - TL Dr. Thomas Davidson (ARDEC) Dr. Edward Wright (MTL) Dr. Robert Lewis (NRDEC) Mr. John Cornette (ONR) Dr. Shen Shey... Dennis Saylor (CINCEUR) Space: Mr. Wends Tovar (ASI) Setting: Mr. Al Waldak (MPRI) Threat Systems- Mr. Stu Prather (FSTC) Facilitators: Mr. Mark Herman

  4. JPRS Report, Science & Technology. China: Stealth/Counter-Stealth Research.

    DTIC Science & Technology

    1992-11-19

    Frequency-Selective Surfaces 92FE0801F Beijing DIANZIXUEBAO [ACTA ELECTRONICA SINICA] in Chinese Vol 20 No 6, Jun 92 pp 85-88 [Article by Shen...microwave devices and electromag- netic scattering. Motion Compensation Method in ISAR Imaging 92FE0801A Beijing DIANZIXUEBAO [ACTA ELECTRONICA ...Chinese Society of Electronics and an editor of DIANZI XUEBAO [ACTA ELECTRONICA SINICA]. Deng Wenbiao Born in February 1961, he graduated from the

  5. China’s Energy Insecurity and the South China Sea Dispute

    DTIC Science & Technology

    2011-03-24

    the South China Sea dispute because of the potential influence of Chinese mercantilism on energy resource acquisition, the US, and its regional...that would afford non-member countries SPR protection in the event of an emergency. Such a move could also help discourage Chinese mercantilism by...33 Brzezinski and Mearsheimer, “Clash of the Titans,” 46-50. 34 Wu Lei and Shen Qinyu, “Will China Go to War Over Oil?,” Far Eastern Economic

  6. ILIR 󈧅: SSC San Diego In-House Laboratory Independent Research 2001 Annual Report

    DTIC Science & Technology

    2002-05-01

    Subpixel Analysis of Hyperspectral Imagery,” SPIE Proceedings: Imaging Spectrometry VII, (M. Descour & S . Shen eds.), vol. 4480. 67 Environmental...for Rational Mechanics & Analysis , (to appear). Sritharan, S . S . and J. L. Menaldi. 2002. “Stochastic 2-D Navier-Stokes Equation,” Applied... S . G. Beaven, L. E. Hoff, E. M. Winter, A. P. Schaum , A. D. Stocker. 2002. “Anomaly Detection from Hyperspectral Imagery,” IEEE Signal Processing

  7. Quantifying the Dynamic Ocean Surface Using Underwater Radiometric Measurement

    DTIC Science & Technology

    2013-09-30

    Radiometric Measurement Lian Shen Department of Mechanical Engineering & St. Anthony Falls Laboratory University of Minnesota Minneapolis, MN...information if it does not display a currently valid OMB control number. 1. REPORT DATE 30 SEP 2013 2. REPORT TYPE 3. DATES COVERED 00-00-2013 to 00-00...2013 4. TITLE AND SUBTITLE Quantifying the Dynamic Ocean Surface Using Underwater Radiometric Measurement 5a. CONTRACT NUMBER 5b. GRANT NUMBER

  8. Variational PDE Models in Image Processing

    DTIC Science & Technology

    2002-07-31

    locate the local or global minima by the gradient descent method. Some of the PDEs can be studied by the viscosity solution approach [24], while many...for smooth functions [31].) This elastica prior model was first studied for inpainting by Masnou and Morel [35], and Chan, Kang, and Shen [11], and...Mumford-Shah inpainting models can be studied in a fashion similar to the classi- cal restoration and segmentation problems. But theoretical study on the

  9. A Multiscale Nested Modeling Framework to Simulate the Interaction of Surface Gravity Waves with Nonlinear Internal Gravity Waves

    DTIC Science & Technology

    2015-09-30

    Interaction of Surface Gravity Waves with Nonlinear Internal Gravity Waves Lian Shen St. Anthony Falls Laboratory and Department of Mechanical...on studying surface gravity wave evolution and spectrum in the presence of surface currents caused by strongly nonlinear internal solitary waves...interaction of surface and internal gravity waves in the South China Sea. We will seek answers to the following questions: 1) How does the wind-wave

  10. Two new species of the leafhopper genus Anidiocerus (Hemiptera: Cicadellidae: Idiocerinae) from China.

    PubMed

    Xue, Qingquan; Webb, M D; Zhang, Yalin

    2013-12-12

    Two new species of Anidiocerus from China, A. brevispinus Xue & Zhang sp. nov. and A. longimus Xue & Zhang sp. nov. are described and illustrated, and A. variabilis Maldonado-Capriles, 1976 is placed as a senior synonym of A. flavidus Cai & Shen, 1998, syn. nov. A redescription of the genus is provided together with a checklist and key for the separation of males. 

  11. Review of the leafhopper genus Oniella Matsumura (Hemiptera: Cicadellidae), with description of a new species from China.

    PubMed

    Min, Gao; Zhang, Yalin

    2013-01-01

    The genus Oniella Matsumura 1912 is reviewed and seven species from China are recognized, including a new species, O. shaanxiana sp. nov., a new synonym, O. flavomarginata, syn. nov. and a new combination, O. albula (Cai & Shen, 1998) n. comb. transferred from Sophonia. O. excelsa (Melichar) is removed from this genus. The seven species are described and illustrated in detail, and a key to all species of the genus is provided.

  12. Computer Simulations of Canada’s RADARSAT2 GMTI

    DTIC Science & Technology

    2000-10-01

    UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP010837 TITLE: Computer Simulations of Canada’s RADARSAT2 GMTI...ADPO10842 UNCLASSIFIED 45-1 Computer Simulations of Canada’s RADARSAT2 GMTI Shen Chiu and Chuck Livingstone Space Systems and Technology Section, Defence...Associates Ltd. 13800 Commerce Parkway, Richmond, B.C., Canada V6V 2J3 Abstract The detection probability and the estimation accuracy Canada’s RADARSAT2

  13. Boundary Korn Inequality and Neumann Problems in Homogenization of Systems of Elasticity

    NASA Astrophysics Data System (ADS)

    Geng, Jun; Shen, Zhongwei; Song, Liang

    2017-02-01

    This paper is concerned with a family of elliptic systems of linear elasticity with rapidly oscillating periodic coefficients, arising in the theory of homogenization. We establish uniform optimal regularity estimates for solutions of Neumann problems in a bounded Lipschitz domain with L 2 boundary data. The proof relies on a boundary Korn inequality for solutions of systems of linear elasticity and uses a large-scale Rellich estimate obtained in Shen (Anal PDE, arXiv:1505.00694v2).

  14. High Resolution Infrared Spectroscopy of Pyrazine and Naphthalene in a Molecular Bean

    DTIC Science & Technology

    1993-10-26

    Infrared Spectroscopy of Pyrazine and Naphthalene in a Molecular Beamby Kevin B. Hewett, Meihua Shen, Christopher L. Brummel, and Laura A. Philips...public release and sale; its distribution is unlimited. 93-26699 HIGH RESOLUTION INFRARED SPECTROSCOPY OF PYRAZINE AND NAPHTHALENE IN A MOLECULAR BEAM...Abstract The high resolution infrared spectrum of pyrazine and naphthalene were measured in a molecular beam in the vicinity of the C-H stretching

  15. Voyaging Beyond the Pillars of Hercules: A Model for the Future Role of Human Spaceflight Exploration in U.S. Grand Strategy

    DTIC Science & Technology

    2013-06-01

    159 x Illustrations (Continued) Figures Page Figure 48: Tsien Hsue-shen, Father of the Chinese Space Program ... 161 Figure 49...193 Figure 56: Members of the Mojave Aerospace Ventures Team Celebrate after the Ansari X PRIZE Winning Flight...spaceplane to a research vehicle like its X -15 predecessor.181 McNamara capped this decision by mandating a name change from Dyna-Soar to X -20

  16. A Genome-Wide Knockout Screen to Identify Genes Involved in Acquired Carboplatin Resistance

    DTIC Science & Technology

    2016-07-01

    or set of genes that were consistently altered in all 6 pairs (14). Other expression profiling and systems biology approaches based on expression...Chemother Pharmacol 2006;58(3):384-95. 15. Chen JY, Yan Z, Shen C, Fitzpatrick DP, Wang M. A systems biology approach to the study of cisplatin drug...Integrative Gene Set Analysis: Application to Platinum Pharmacogenomics. Omics : a journal of integrative biology 2013. 17. Oliver TG, Mercer KL, Sayles LC

  17. Realignment criteria for recognizing multipartite entanglement of quantum states

    NASA Astrophysics Data System (ADS)

    Zhang, Yan-Hua; Lu, Yuan-Yuan; Wang, Guang-Bin; Shen, Shu-Qian

    2017-04-01

    By multiple realignments of density matrices, we present a new separability criterion for the multipartite quantum state, which includes the computable cross-norm or realignment criterion and the multipartite partial realignment criterion as special cases. An example is used to show that the new criterion can be more efficient than the corresponding multipartite realignment criteria given in Horodecki et al. (Open Syst Inf Dyn 13:103-111, 2006) and Shen et al. (Phys Rev A 92:042332, 2015).

  18. Design of Tunable, Thin, and Wide-band Microwave Absorbers

    DTIC Science & Technology

    2012-04-05

    switchable or tunable radar absorbers, which are very useful in electromagnetic compatibility test facilities, radar camouflage and deception roles, and...applications requires switchable or tunable radar absorbers, which are very useful in electromagnetic compatibility test facilities, radar camouflage ...2012. [2] Q. Zhang and Z. Shen, “A dual-polarized switchable microwave absorber,” IEEE AP- S International Symposium , Chicago, July 2012.

  19. China’s Manned Space Program: Sun Tzu or Apollo Redux

    DTIC Science & Technology

    2003-01-01

    space can be found in Daniel Gonzales, The Changing Role of the U.S. Military in Space, MR-85-AF (Santa Monica, Calif.: RAND, 1999); Roger Handberg, New...shuttle and other space programs as well. 13. Jean-Jacques Servan-Schreiber, The American Challenge (New York: Avon Books, 1967); Roger Williams...stop it, even putting armed guards at some facilities. 22. His name is sometimes spelled Chien Hsue- shen, or Tsien Hsueshen. 23. See the description in

  20. Scheduling and Topology Design in Networks with Directional Antennas

    DTIC Science & Technology

    2017-05-19

    2006. [2] A. Alexiou and M. Haardt, “Smart Antenna Technologies for Future Wire- less Systems: Trends and Challenges.” IEEE Communications Magazine...Shen, “Multibeam antenna-based topology control with directional power intensity for ad hoc networks, IEEE Trans. Mobile Computing, vol. 5, no. 5...5] V. Namboodiri, L. Gao, and R. Janaswamy, “Power Efficient Topology Control for Wireless Networks with Switched Beam Directional Anten- nas, IEEE