Science.gov

Sample records for government regulation

  1. Regulating the New Governance

    ERIC Educational Resources Information Center

    Cope, Stephen; Goodship, Jo; Holloway, David

    2003-01-01

    This article arises out of a research project that sought to assess the development of regulation within the public sector. It examines the forms and impact of the regulatory systems that now operate within the public sector focusing on the further education sector. The research project developed out of an awareness that the increase in various…

  2. 31 CFR 342.8 - Governing regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Governing regulations. Savings notes are subject to the regulations of the Department of the Treasury, now or hereafter prescribed, governing United States Savings Bonds, contained in 31 CFR part 315, also... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Governing regulations. 342.8...

  3. 31 CFR 342.8 - Governing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Governing regulations. Savings notes are subject to the regulations of the Department of the Treasury, now or hereafter prescribed, governing United States Savings Bonds, contained in 31 CFR part 315, also... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Governing regulations. 342.8...

  4. 31 CFR 342.8 - Governing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Governing regulations. Savings notes are subject to the regulations of the Department of the Treasury, now or hereafter prescribed, governing United States Savings Bonds, contained in 31 CFR part 315, also... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Governing regulations. 342.8...

  5. 31 CFR 342.8 - Governing regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Governing regulations. Savings notes are subject to the regulations of the Department of the Treasury, now or hereafter prescribed, governing United States Savings Bonds, contained in 31 CFR part 315, also... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Governing regulations. 342.8...

  6. 31 CFR 342.8 - Governing regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Governing regulations. Savings notes are subject to the regulations of the Department of the Treasury, now or hereafter prescribed, governing United States Savings Bonds, contained in 31 CFR part 315, also... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Governing regulations. 342.8...

  7. 31 CFR 316.3 - Governing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....3 Governing regulations. (a) The regulations in 31 CFR part 315 apply to definitive Series E bonds that have not been converted to book-entry bonds. (b) The regulations in 31 CFR part 363 apply to... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Governing regulations. 316.3...

  8. 31 CFR 316.3 - Governing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....3 Governing regulations. (a) The regulations in 31 CFR part 315 apply to definitive Series E bonds that have not been converted to book-entry bonds. (b) The regulations in 31 CFR part 363 apply to... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Governing regulations. 316.3...

  9. 31 CFR 316.3 - Governing regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....3 Governing regulations. (a) The regulations in 31 CFR part 315 apply to definitive Series E bonds that have not been converted to book-entry bonds. (b) The regulations in 31 CFR part 363 apply to... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Governing regulations. 316.3...

  10. 31 CFR 316.3 - Governing regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... § 316.3 Governing regulations. (a) The regulations in 31 CFR part 315 apply to definitive Series E bonds that have not been converted to book-entry bonds. (b) The regulations in 31 CFR part 363 apply to... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Governing regulations. 316.3...

  11. 31 CFR 316.3 - Governing regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....3 Governing regulations. (a) The regulations in 31 CFR part 315 apply to definitive Series E bonds that have not been converted to book-entry bonds. (b) The regulations in 31 CFR part 363 apply to... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Governing regulations. 316.3...

  12. 31 CFR 332.3 - Governing regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., H, J and K, contained in 31 CFR part 315, also published as Department of the Treasury Circular No... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Governing regulations. 332.3 Section....3 Governing regulations. Series H bonds are subject to the regulations of the Department of...

  13. 31 CFR 332.3 - Governing regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., H, J and K, contained in 31 CFR part 315, also published as Department of the Treasury Circular No... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Governing regulations. 332.3 Section... § 332.3 Governing regulations. Series H bonds are subject to the regulations of the Department of...

  14. 31 CFR 352.1 - Governing regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in Department of the Treasury Circular, Public Debt Series No. 3-80, as amended (31 CFR part 353... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Governing regulations. 352.1 Section....1 Governing regulations. Series HH bonds are subject to the regulations of the Department of...

  15. 31 CFR 352.1 - Governing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... in Department of the Treasury Circular, Public Debt Series No. 3-80, as amended (31 CFR part 353... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Governing regulations. 352.1 Section....1 Governing regulations. Series HH bonds are subject to the regulations of the Department of...

  16. 31 CFR 352.1 - Governing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... in Department of the Treasury Circular, Public Debt Series No. 3-80, as amended (31 CFR part 353... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Governing regulations. 352.1 Section....1 Governing regulations. Series HH bonds are subject to the regulations of the Department of...

  17. 31 CFR 339.5 - Governing regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Governing regulations. 339.5 Section 339.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... H § 339.5 Governing regulations. All Series H bonds issued under this circular are subject to...

  18. 31 CFR 339.5 - Governing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Governing regulations. 339.5 Section 339.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... H § 339.5 Governing regulations. All Series H bonds issued under this circular are subject to...

  19. 31 CFR 352.1 - Governing regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in Department of the Treasury Circular, Public Debt Series No. 3-80, as amended (31 CFR part 353... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Governing regulations. 352.1 Section....1 Governing regulations. Series HH bonds are subject to the regulations of the Department of...

  20. 31 CFR 332.3 - Governing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., H, J and K, contained in 31 CFR part 315, also published as Department of the Treasury Circular No... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Governing regulations. 332.3 Section....3 Governing regulations. Series H bonds are subject to the regulations of the Department of...

  1. 31 CFR 339.5 - Governing regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Governing regulations. 339.5 Section 339.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE..., SERIES H § 339.5 Governing regulations. All Series H bonds issued under this circular are subject to...

  2. 31 CFR 332.3 - Governing regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., H, J and K, contained in 31 CFR part 315, also published as Department of the Treasury Circular No... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Governing regulations. 332.3 Section....3 Governing regulations. Series H bonds are subject to the regulations of the Department of...

  3. 31 CFR 352.1 - Governing regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in Department of the Treasury Circular, Fiscal Service Series No. 3-80, as amended (31 CFR part 353... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Governing regulations. 352.1 Section... § 352.1 Governing regulations. Series HH bonds are subject to the regulations of the Department of...

  4. 31 CFR 339.5 - Governing regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Governing regulations. 339.5 Section 339.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... H § 339.5 Governing regulations. All Series H bonds issued under this circular are subject to...

  5. 31 CFR 339.5 - Governing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Governing regulations. 339.5 Section 339.5 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... H § 339.5 Governing regulations. All Series H bonds issued under this circular are subject to...

  6. 31 CFR 332.3 - Governing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., H, J and K, contained in 31 CFR part 315, also published as Department of the Treasury Circular No... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Governing regulations. 332.3 Section....3 Governing regulations. Series H bonds are subject to the regulations of the Department of...

  7. Effects of Government Regulations on Higher Education.

    ERIC Educational Resources Information Center

    Bernhard, John T.; Hannah, Robert W.

    Results of a self-study conducted by Western Michigan University on the effects of government regulations on higher education are presented. The self-study, conducted with the aid of questionnaires, followup visits, or telephone calls, addressed the following main concerns: (1) academic programs; (2) maintenance, buildings, physical plant, and…

  8. International Religion Indexes: Government Regulation, Government Favoritism, and Social Regulation of Religion*

    PubMed Central

    Grim, Brian J.; Finke, Roger

    2014-01-01

    The study of religion is severely handicapped by a lack of adequate cross-national data. Despite the prominence of religion in international events and recent theoretical models pointing to the consequences of regulating religion, cross-national research on religion has been lacking. We strive to fill this void by developing measurement models and indexes for government regulation, government favoritism, and social regulation of religion. The indexes rely on data from an extensive coding of the 2003 International Religious Freedom Report for 196 countries and territories. Using a series of tests to evaluate the new data and indexes, we find that the measures developed are highly reliable and valid. The three indexes will allow researchers and others to measure the government’s subsidy and regulation of religion as well as the restrictions placed on religion by social and cultural forces beyond the state. PMID:25484633

  9. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Regulations governing navigable... ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.200 Regulations governing navigable waters... of the Army to govern navigation and navigable waters, are contained in the Code of...

  10. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Regulations governing navigable... ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.200 Regulations governing navigable waters... of the Army to govern navigation and navigable waters, are contained in the Code of...

  11. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Regulations governing navigable... ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.200 Regulations governing navigable waters... of the Army to govern navigation and navigable waters, are contained in the Code of...

  12. 78 FR 26518 - Federal Acquisition Regulation; Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE... Acquisition Regulation; Government Property CFR Correction In Title 48 of the Code of Federal Regulations... Government (Fixed-Price). * * * * * (i) The cost principles and procedures of part 31 of the...

  13. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Regulation governing imports of walnuts. 999.100... SPECIALTY CROPS; IMPORT REGULATIONS § 999.100 Regulation governing imports of walnuts. (a) Definitions. (1) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2)...

  14. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Regulation governing imports of walnuts. 999.100... SPECIALTY CROPS; IMPORT REGULATIONS § 999.100 Regulation governing imports of walnuts. (a) Definitions. (1) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2)...

  15. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Regulation governing imports of walnuts. 999.100... SPECIALTY CROPS; IMPORT REGULATIONS § 999.100 Regulation governing imports of walnuts. (a) Definitions. (1) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2)...

  16. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Regulation governing imports of walnuts. 999.100... SPECIALTY CROPS; IMPORT REGULATIONS § 999.100 Regulation governing imports of walnuts. (a) Definitions. (1) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2)...

  17. 7 CFR 61.5 - Regulations to govern.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Regulations to govern. 61.5 Section 61.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... General § 61.5 Regulations to govern. The inspection, sampling, analyzing, and grading of cottonseed...

  18. 7 CFR 61.5 - Regulations to govern.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Regulations to govern. 61.5 Section 61.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... General § 61.5 Regulations to govern. The inspection, sampling, analyzing, and grading of cottonseed...

  19. 7 CFR 61.5 - Regulations to govern.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Regulations to govern. 61.5 Section 61.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... General § 61.5 Regulations to govern. The inspection, sampling, analyzing, and grading of cottonseed...

  20. 43 CFR 8341.1 - Regulations governing use.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Regulations governing use. 8341.1 Section 8341.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Regulations governing use. (a) The operation of off-road vehicles is permitted on those areas and...

  1. 7 CFR 61.5 - Regulations to govern.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Regulations to govern. 61.5 Section 61.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... General § 61.5 Regulations to govern. The inspection, sampling, analyzing, and grading of cottonseed...

  2. 43 CFR 8341.1 - Regulations governing use.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Regulations governing use. 8341.1 Section 8341.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Regulations governing use. (a) The operation of off-road vehicles is permitted on those areas and...

  3. 43 CFR 8341.1 - Regulations governing use.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Regulations governing use. 8341.1 Section 8341.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Regulations governing use. (a) The operation of off-road vehicles is permitted on those areas and...

  4. 7 CFR 61.5 - Regulations to govern.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Regulations to govern. 61.5 Section 61.5 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... General § 61.5 Regulations to govern. The inspection, sampling, analyzing, and grading of cottonseed...

  5. 43 CFR 8341.1 - Regulations governing use.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Regulations governing use. 8341.1 Section 8341.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... Regulations governing use. (a) The operation of off-road vehicles is permitted on those areas and...

  6. 76 FR 39788 - Regulations Governing Fees for Services

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services AGENCY: Surface Transportation Board. ACTION: Final rule. SUMMARY: The Board is amending the regulations governing user fees for services performed. The amendment sets the fee for certain formal complaints at $350. DATES: Effective...

  7. 76 FR 9527 - Regulations Governing Fees for Services

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services AGENCY: Surface... regulations governing user fees for ] services. The proposed amendment would set the fee for certain formal... fees in accordance with the Independent Offices Appropriation Act of 1952 (IOAA). The IOAA...

  8. 76 FR 18497 - Federal Acquisition Regulation; Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ..., 49, 52, and 53 RIN 9000-AL95 Federal Acquisition Regulation; Government Property AGENCIES: Department... Acquisition Regulation (FAR) to clarify reporting, reutilization, and disposal of Government property and the..., published in the Federal Register at 75 FR 38675 on July 2, 2010), that were deemed to be outside the...

  9. 77 FR 75362 - Government in the Sunshine Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1612 Government in the Sunshine Act Regulations CFR Correction 0 In Title 29 of the Code of Federal Regulations, Parts 900 to 1899, revised as of July 1, 2012, on page 266, in Sec....

  10. Bureaucrats and Brainpower: Government Regulation of Universities.

    ERIC Educational Resources Information Center

    Seabury, Paul, Ed.

    The exploration of the growth and cost benefit effectiveness of governmental regulation of higher education is examined in this book. An introductory article by Robert Hatfield examines university regulation from a businessman's perspective. Hatfield concludes that business and higher education must work together to curb the stream of regulation.…

  11. 76 FR 18072 - Federal Acquisition Regulation; Government Property Disposal; Forms

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 53 Federal Acquisition Regulation; Government Property Disposal; Forms CFR Correction In Title 48 of the Code of...

  12. 49 CFR 390.207 - Other governing regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... subject to the requirements of 49 CFR part 107, subpart F, 49 CFR part 172, subpart H, and 49 CFR part 180. ... 49 Transportation 5 2014-10-01 2014-10-01 false Other governing regulations. 390.207 Section 390... MOTOR CARRIER SAFETY REGULATIONS; GENERAL Unified Registration System § 390.207 Other...

  13. 49 CFR 390.207 - Other governing regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... subject to the requirements of 49 CFR part 107, subpart F, 49 CFR part 172, subpart H, and 49 CFR part 180. ... 49 Transportation 5 2013-10-01 2013-10-01 false Other governing regulations. 390.207 Section 390... MOTOR CARRIER SAFETY REGULATIONS; GENERAL Unified Registration System § 390.207 Other...

  14. 7 CFR 999.300 - Regulation governing importation of raisins.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Regulation governing importation of raisins. 999.300 Section 999.300 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF...

  15. SIGNALS AND REGULATORS THAT GOVERN STREPTOMYCES DEVELOPMENT

    PubMed Central

    McCormick, Joseph R.; Flärdh, Klas

    2012-01-01

    Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the Gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex, and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae, first to form specialized aerial hyphae, and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from “-omics” studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve. PMID:22092088

  16. 31 CFR 380.0 - What do these regulations govern?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... regulations at 31 CFR part 202 (Depositaries and Financial Agents of the Government), 31 CFR part 203 (Payment of Federal Taxes and the Treasury Tax and Loan Program), and 31 CFR part 225 (Acceptance of Bonds... to the acceptability and valuation of collateral that may be pledged under these programs. 31...

  17. 31 CFR 380.0 - What do these regulations govern?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... regulations at 31 CFR part 202 (Depositaries and Financial Agents of the Government), 31 CFR part 203 (Payment of Federal Taxes and the Treasury Tax and Loan Program), and 31 CFR part 225 (Acceptance of Bonds... to the acceptability and valuation of collateral that may be pledged under these programs. 31...

  18. 31 CFR 380.0 - What do these regulations govern?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... regulations at 31 CFR part 202 (Depositaries and Financial Agents of the Government), 31 CFR part 203 (Payment of Federal Taxes and the Treasury Tax and Loan Program), and 31 CFR part 225 (Acceptance of Bonds... to the acceptability and valuation of collateral that may be pledged under these programs. 31...

  19. 31 CFR 380.0 - What do these regulations govern?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations at 31 CFR part 202 (Depositaries and Financial Agents of the Government), 31 CFR part 203 (Payment of Federal Taxes and the Treasury Tax and Loan Program), and 31 CFR part 225 (Acceptance of Bonds... to the acceptability and valuation of collateral that may be pledged under these programs. 31...

  20. 31 CFR 380.0 - What do these regulations govern?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations at 31 CFR part 202 (Depositaries and Financial Agents of the Government), 31 CFR part 203 (Payment of Federal Taxes and the Treasury Tax and Loan Program), and 31 CFR part 225 (Acceptance of Bonds... to the acceptability and valuation of collateral that may be pledged under these programs. 31...

  1. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regulations governing exemptions. 230.161 Section 230.161 Commodity and Securities Exchanges SECURITIES AND... rules and regulations governing exemptions. The rules and regulations governing the exemption of... to the public in conformity therewith, shall continue to govern the exemption of such...

  2. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... regulations governing exemptions. 230.161 Section 230.161 Commodity and Securities Exchanges SECURITIES AND... rules and regulations governing exemptions. The rules and regulations governing the exemption of... to the public in conformity therewith, shall continue to govern the exemption of such...

  3. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... regulations governing exemptions. 230.161 Section 230.161 Commodity and Securities Exchanges SECURITIES AND... rules and regulations governing exemptions. The rules and regulations governing the exemption of... to the public in conformity therewith, shall continue to govern the exemption of such...

  4. 34 CFR 655.1 - Which programs do these regulations govern?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false Which programs do these regulations govern? 655.1 Section 655.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... § 655.1 Which programs do these regulations govern? The regulations in this part govern...

  5. 34 CFR 655.1 - Which programs do these regulations govern?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false Which programs do these regulations govern? 655.1 Section 655.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... § 655.1 Which programs do these regulations govern? The regulations in this part govern...

  6. 34 CFR 655.1 - Which programs do these regulations govern?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false Which programs do these regulations govern? 655.1 Section 655.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... § 655.1 Which programs do these regulations govern? The regulations in this part govern...

  7. 34 CFR 655.1 - Which programs do these regulations govern?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Which programs do these regulations govern? 655.1 Section 655.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF... § 655.1 Which programs do these regulations govern? The regulations in this part govern...

  8. Should states and local governments regulate dietary supplements?

    PubMed

    Starr, Ranjani

    2016-01-01

    Federal regulation of dietary supplements in the United States is governed by the Dietary Supplement Health and Education Act of 1994. The law has been criticized as weak and ineffective. Alarming research has emerged demonstrating that supplements may be mislabelled, contaminated, adulterated with dangerous or unknown compounds, or sold at toxic doses. As a result, the health community has raised concerns about the safety and quality of dietary supplements. Increased federal oversight is an important avenue for improving supplement safety; however, states and local governments may also pursue strategies to strengthen the overall regulatory control of dietary supplements. States and local governments have substantial experience in regulating other products that pose a risk to public health, such as tobacco. Additionally, much has been learned about the tactics the tobacco industry has employed to protect its interests. Lessons learned may be applied to new regulatory efforts aimed at improving the safety of dietary supplements at the state and local levels. Copyright © 2015 John Wiley & Sons, Ltd.

  9. Understanding Philip Morris's pursuit of US government regulation of tobacco

    PubMed Central

    McDaniel, P; Malone, R

    2005-01-01

    Objective: To investigate Philip Morris's support of US Food and Drug Administration (FDA) regulation of tobacco products and analyse its relationship to the company's image enhancement strategies. Data sources: Internal Philip Morris documents released as part of the Master Settlement Agreement. Methods: Searches of the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) beginning with such terms as "FDA" and "regulatory strategy" and expanding to include relevant new terms. Results: Philip Morris's support for government regulation of tobacco is part of a broader effort to address its negative public image, which has a damaging impact on the company's stock price, political influence, and employee morale. Through regulation, the company seeks to enhance its legitimacy, redefine itself as socially responsible, and alter the litigation environment. Whereas health advocates frame tobacco use as a public health policy issue, Philip Morris's regulatory efforts focus on framing tobacco use as an individual choice by informed adults to use a risky product. This framing allows Philip Morris to portray itself as a reasonable and responsible manufacturer and marketer of risky products. Conclusions: Philip Morris's ability to improve its image through support of FDA regulation may undermine tobacco control efforts aimed at delegitimising the tobacco industry. It may also create the impression that Philip Morris's products are being made safer and ultimately protect the company from litigation. While strong regulation of tobacco products and promotion remain critical public health goals, previous experiences with tobacco regulation show that caution may be warranted. PMID:15923470

  10. Government regulation to promote healthy food environments--a view from inside state governments.

    PubMed

    Shill, J; Mavoa, H; Allender, S; Lawrence, M; Sacks, G; Peeters, A; Crammond, B; Swinburn, B

    2012-02-01

    Food policy interventions are an important component of obesity-prevention strategies and can potentially drive positive changes in obesogenic environments. This study sought to identify regulatory interventions targeting the food environment, and barriers/facilitators to their implementation at the Australian state government level. In-depth interviews were conducted with senior representatives from state/territory governments, statutory authorities and non-government organizations (n =45) to examine participants' (i) suggestions for regulatory interventions for healthier food environments and (ii) support for pre-selected regulatory interventions derived from a literature review. Data were analysed using thematic and constant comparative analyses. Interventions commonly suggested by participants were regulating unhealthy food marketing; limiting the density of fast food outlets; pricing reforms to decrease fruit/vegetable prices and increase unhealthy food prices; and improved food labelling. The most commonly supported pre-selected interventions were related to food marketing and service. Primary production and retail sector interventions were least supported. The dominant themes were the need for whole-of-government and collaborative approaches; the influence of the food industry; conflicting policies/agenda; regulatory challenges; the need for evidence of effectiveness; and economic disincentives. While interventions such as public sector healthy food service policies were supported by participants, marketing restrictions and fiscal interventions face substantial barriers including a push for deregulation and private sector opposition.

  11. Government regulation to promote healthy food environments--a view from inside state governments.

    PubMed

    Shill, J; Mavoa, H; Allender, S; Lawrence, M; Sacks, G; Peeters, A; Crammond, B; Swinburn, B

    2012-02-01

    Food policy interventions are an important component of obesity-prevention strategies and can potentially drive positive changes in obesogenic environments. This study sought to identify regulatory interventions targeting the food environment, and barriers/facilitators to their implementation at the Australian state government level. In-depth interviews were conducted with senior representatives from state/territory governments, statutory authorities and non-government organizations (n =45) to examine participants' (i) suggestions for regulatory interventions for healthier food environments and (ii) support for pre-selected regulatory interventions derived from a literature review. Data were analysed using thematic and constant comparative analyses. Interventions commonly suggested by participants were regulating unhealthy food marketing; limiting the density of fast food outlets; pricing reforms to decrease fruit/vegetable prices and increase unhealthy food prices; and improved food labelling. The most commonly supported pre-selected interventions were related to food marketing and service. Primary production and retail sector interventions were least supported. The dominant themes were the need for whole-of-government and collaborative approaches; the influence of the food industry; conflicting policies/agenda; regulatory challenges; the need for evidence of effectiveness; and economic disincentives. While interventions such as public sector healthy food service policies were supported by participants, marketing restrictions and fiscal interventions face substantial barriers including a push for deregulation and private sector opposition. PMID:21955783

  12. Effect of Government Regulation on the Evolution of Sports Nutrition

    NASA Astrophysics Data System (ADS)

    Collins, Rick; Kalman, Douglas

    The sports nutrition segment of the dietary supplement industry enjoyed nearly a decade of unfettered growth under federal legislation passed in 1994. A series of breakthroughs in the dietary supplement field led to the development and marketing of innovative products designed to enhance performance, build muscle, or lose excess fat. As the popularity of these products soared and evolved into a multi-billion dollar industry, the sports nutrition supplement market drew the attention of federal and state regulatory bodies and sports antidoping authorities. Growing concerns over potential health risks and unfair athletic advantages have spurred government regulators and legislators to heighten the scrutiny of this market, leading to recent legislative amendments and increased government enforcement action.

  13. Impact of government regulation on health care technology

    NASA Astrophysics Data System (ADS)

    Berkowitz, Robert D.

    1994-12-01

    Increased government regulation of the medical device industry produces higher expenses, a longer time to return investment capital, and greater uncertainty. As a result there are fewer new ventures and reduced efforts to develop new technology in established companies. The current federal regulatory framework has shifted from monitoring the product to monitoring the process. The inability to reach perfect performance in such a regulated environment subject to continuous and fluid interpretation guarantees non-compliance and growing ethical tension. Without new medical technology, we may be unable to maintain quality medical coverage in the face of rising demand. The author proposes risk assessment to set regulatory priorities; the conversion of a national weapons lab to a national device testing lab; the establishment of device standards and the monitoring of in-use performance against these standards; and the education of patients and users as to the results of these examinations.

  14. Pharmaceuticals in Australia: developments in regulation and governance.

    PubMed

    Lofgren, Hans; Boer, Rebecca de

    2004-06-01

    The pharmaceutical domain represents a type of internationalised policy network theorised in recent writings on neo-liberalism, neo-corporatism and governance. This article presents an analysis of developments in prescription drug regulation in Australia. A relatively stable, state-managed pattern of interaction has been superseded by less closed exchange, and the government itself has fragmented into agencies pursuing different objectives. Developments in the three core regulatory areas are described: safety and efficacy controls, social policy (access and equity), and state support for industry (economic) development. Consensus-building occurs within the context of the National Medicines Policy. The pharmaceutical industry, represented by Medicines Australia, has a stake in all aspects of pharmaceutical policy and regulation, and draws upon unique resources (expertise and lobbying capacity). The context for the developments described is Australia's abandonment of a protectionist version of the Keynesian welfare national state in favour of the model of the competition state, which is oriented towards support for the growth of high technology industries such as pharmaceuticals, premised on partnerships with business. PMID:15081192

  15. Controversy over genetically modified organisms: the governing laws and regulations.

    PubMed

    Keatley, K L

    2000-01-01

    Genetically Modified Organisms (GMOs) are increasingly becoming a topic of controversy in the U.S. and abroad. The public is questioning their safety and wanting the products labeled as genetically modified. There are other concerns from some of the scientific world and some government officials and organizations such as the Food & Agricultural Organization (FAO) that question whether adequate research has been done to qualify GMOs as safe for long-term use. Of particular concern are the allergenic properties, a GMO may impart, possible transfer effects of antibiotic resistance (given that antibiotic resistant marker genes are used for many GMOs), the expression of previously unexpressed traits, and the drift of pollen from genetically modified crops. It has also been noted that the laws and regulations governing the biotechnology world are outdated, are not comprehensive, and span too many agencies. The primary agencies currently regulating biotechnology are the U.S. Department of Agriculture (USDA), the Food and Drug Administration (FDA), and the Environmental Protection Agency (EPA).

  16. Governing inside the organization: interpreting regulation and compliance.

    PubMed

    Gray, Garry C; Silbey, Susan S

    2014-07-01

    Looking inside organizations at the different positions, expertise, and autonomy of the actors, the authors use multisite ethnographic data on safety practices to develop a typology of how the regulator, as the focal actor in the regulatory process, is interpreted within organizations. The findings show that organizational actors express constructions of the regulator as an ally, threat, and obstacle that vary with organizational expertise, authority, and continuity of relationship between the organizational member and the regulator. The article makes three contributions to the current understandings of organizational governance and regulatory compliance, thereby extending both institutional and ecological accounts of organizations' behavior with respect to their environments. First, the authors document not only variation across organizations but variable compliance within an organization. Second, the variations described do not derive from alternative institutional logics, but from variations in positions, autonomy, and expertise within each organization. From their grounded theory, the authors hypothesize that these constructions carry differential normative interpretations of regulation and probabilities for compliance, and thus the third contribution, the typology, when correlated with organizational hierarchy provides the link between microlevel action and discourse and organizational performance. PMID:25705781

  17. 14 CFR 221.61 - Rules and regulations governing foreign air transportation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Rules and regulations governing foreign air... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.61 Rules and regulations governing foreign air transportation. Instead of being included in the fares tariffs, the rules...

  18. 14 CFR 221.61 - Rules and regulations governing foreign air transportation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Rules and regulations governing foreign air... (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.61 Rules and regulations governing foreign air transportation. Instead of being included in the fares tariffs, the rules...

  19. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees E Appendix E to Part 99 Transportation Office of the Secretary of Transportation EMPLOYEE RESPONSIBILITIES AND CONDUCT Pt. 99, App. E Appendix E...

  20. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees E Appendix E to Part 99 Transportation Office of the Secretary of Transportation EMPLOYEE RESPONSIBILITIES AND CONDUCT Pt. 99, App. E Appendix E...

  1. 75 FR 80426 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... Regulation Supplement; Reporting of Government-Furnished Property AGENCY: Defense Acquisition Regulations... reporting requirements for Government-furnished property to include items uniquely and non-uniquely... Government-furnished property (GFP) with existing unique item identification to the DoD IUID Registry;...

  2. 75 FR 927 - Migratory Bird Permits; Changes in the Regulations Governing Falconry

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-07

    ... Federal Register (73 FR 59448) to revise our regulations governing falconry in the United States. We... (75 FR 36158) to clarify or correct some provisions in the rule. Comments on the Proposed Rule We..., 1994, ``Government-to-Government Relations with Native American Tribal Governments'' (59 FR...

  3. 49 CFR 805.735-14 - Specific regulations for special Government employees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... regulations for special Government employees. (a) Use of Board affiliation. A special Government employee of... Government employee shall not use inside information obtained as a result of his employment by the Board for...) Receipt of gifts, entertainment, and favors. (1) A special Government employee, while employed by...

  4. 29 CFR 785.46 - Applicable regulations governing keeping of records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Applicable regulations governing keeping of records. 785.46 Section 785.46 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... Working Time § 785.46 Applicable regulations governing keeping of records. Section 11(c) of the...

  5. 43 CFR 1812.1-1 - Regulations governing practice before the Department.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Regulations governing practice before the Department. 1812.1-1 Section 1812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued... GUIDANCE Qualifications of Practitioners § 1812.1-1 Regulations governing practice before the...

  6. 29 CFR 785.46 - Applicable regulations governing keeping of records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Applicable regulations governing keeping of records. 785.46 Section 785.46 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... Working Time § 785.46 Applicable regulations governing keeping of records. Section 11(c) of the...

  7. 43 CFR 1812.1-1 - Regulations governing practice before the Department.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Regulations governing practice before the Department. 1812.1-1 Section 1812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued... GUIDANCE Qualifications of Practitioners § 1812.1-1 Regulations governing practice before the...

  8. 29 CFR 785.46 - Applicable regulations governing keeping of records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Applicable regulations governing keeping of records. 785.46 Section 785.46 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR... Working Time § 785.46 Applicable regulations governing keeping of records. Section 11(c) of the...

  9. Performance Government: Activating and Regulating the Self-Governing Capacities of Teachers and School Leaders

    ERIC Educational Resources Information Center

    O'Brien, Peter C.

    2015-01-01

    This article analyses "performance government" as an emergent form of rule in advanced liberal democracies. It discloses how teachers and school leaders in Australia are being governed by the practices of performance government which centre on the recently established Australian Institute for Teaching and School Leadership (AITSL) and…

  10. Analysis of combinatorial regulation: scaling of partnerships between regulators with the number of governed targets.

    PubMed

    Bhardwaj, Nitin; Carson, Matthew B; Abyzov, Alexej; Yan, Koon-Kiu; Lu, Hui; Gerstein, Mark B

    2010-05-01

    Through combinatorial regulation, regulators partner with each other to control common targets and this allows a small number of regulators to govern many targets. One interesting question is that given this combinatorial regulation, how does the number of regulators scale with the number of targets? Here, we address this question by building and analyzing co-regulation (co-transcription and co-phosphorylation) networks that describe partnerships between regulators controlling common genes. We carry out analyses across five diverse species: Escherichia coli to human. These reveal many properties of partnership networks, such as the absence of a classical power-law degree distribution despite the existence of nodes with many partners. We also find that the number of co-regulatory partnerships follows an exponential saturation curve in relation to the number of targets. (For E. coli and Bacillus subtilis, only the beginning linear part of this curve is evident due to arrangement of genes into operons.) To gain intuition into the saturation process, we relate the biological regulation to more commonplace social contexts where a small number of individuals can form an intricate web of connections on the internet. Indeed, we find that the size of partnership networks saturates even as the complexity of their output increases. We also present a variety of models to account for the saturation phenomenon. In particular, we develop a simple analytical model to show how new partnerships are acquired with an increasing number of target genes; with certain assumptions, it reproduces the observed saturation. Then, we build a more general simulation of network growth and find agreement with a wide range of real networks. Finally, we perform various down-sampling calculations on the observed data to illustrate the robustness of our conclusions. PMID:20523742

  11. 77 FR 24611 - Removal of Regulations Requiring 3% Withholding by Government Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... affects government entities that would have been required to withhold and report tax from payments to... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY... Government Entities AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Final regulations....

  12. 76 FR 11190 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property (DFARS Case 2009-D043) AGENCY... (DFARS) to revise and expand reporting requirements for Government-furnished property to include items... to the e-mail address identified at http://www.acq.osd.mil/dpap/dars/Government-furnished...

  13. 76 FR 12666 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property AGENCY: Defense Acquisition... and expand reporting requirements for Government-furnished property to include items uniquely and non..., go to-- http://www.acq.osd.mil/dpap/dars/government_furnished_property.html and submit the...

  14. 75 FR 35684 - Defense Federal Acquisition Regulation Supplement; Ownership or Control by a Foreign Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 209 and 252 Defense Federal Acquisition Regulation Supplement; Ownership or Control by a Foreign Government (DFARS Case 2010-D010) AGENCY: Defense...

  15. 46 CFR 30.01-10 - Application of regulations governing alterations or repairs-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Application of regulations governing alterations or repairs-TB/ALL. 30.01-10 Section 30.01-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Administration § 30.01-10 Application of regulations governing alterations...

  16. Government Legislation and Regulations in the United States

    EPA Science Inventory

    For centuries, customary or traditional laws have covered the use of biological resources throughout the world. As human population levels increase in all societies, voluntary actions governed by cultural practices are frequently insufficient to protect biodiversity, leading to...

  17. 75 FR 79455 - OPEN GOVERNMENT AND EVIDENCE-BASED REGULATION

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... `` nowledge is widely dispersed in society, and public officials benefit from having access to that dispersed...: Openness promotes not merely accountability, but also access to widely dispersed information. The central... private sphere. When it is working well, open government can ensure that rules are properly informed...

  18. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false What regulations govern Series...

  19. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What regulations govern Series...

  20. State Laws and Regulations Governing Teachers Certificates. Bulletin, 1921, No. 22

    ERIC Educational Resources Information Center

    Cook, Katherine M.

    1921-01-01

    This study is intended to present information as complete as possible concerning the laws and regulations which govern the issue of teachers' certificates in the United States in so far as they are regulated by State legislation or State administrative departments. Licenses to teach issued by city boards in accordance with regulations prescribed…

  1. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false What regulations govern Series...

  2. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false What regulations govern Series...

  3. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false What regulations govern Series...

  4. Government Regulation of the Pursuit of Knowledge: The Recombinant DNA Controversy.

    ERIC Educational Resources Information Center

    Berger, Richard G.

    1978-01-01

    Government regulation of recombinant DNA research is addressed. Issues discussed include the potential of such research; National Institutes of Health guidelines; federal, state, and local regulation; the controversy over self-regulation; first amendment protection for scientific research; and problems in drafting legislation. (JMD)

  5. The Federal 504 Handicapped Access Regulations: A Case Study in Government-Higher Education Relations.

    ERIC Educational Resources Information Center

    Bailey, Cornelia W.

    Development and implementation of the Federal 504 Handicapped Access Regulations of the Rehabilitation Act of 1973 and the relationship between the government and higher education institutions are considered. The legislative history and overview of the regulations, institutional responses to the regulations, problems experienced by institutions…

  6. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  7. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  8. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  9. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  10. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  11. 75 FR 38765 - Domestic Origin Verification System Questionnaire and Regulations Governing Inspection and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-06

    ... Inspection and Certification of Processed Fruits and Vegetables and Related Products AGENCY: Agricultural... to Chere L. Shorter, Processed Products Branch, Fruit and Vegetable Programs, Agricultural Marketing... System Questionnaire and Regulations Governing Inspection and Certification of Processed Fruits...

  12. 75 FR 40754 - Government in the Sunshine Act Regulations of the National Science Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION 45 CFR Part 614 RIN 3145-AA53 Government in the Sunshine Act Regulations of the National Science Board AGENCY: National Science Board (NSB), National Science Foundation (NSF). ACTION: Direct final...

  13. How State and Local Governments Regulate Economic Activities: A Consumer Briefing.

    ERIC Educational Resources Information Center

    Nelson, Helen E.

    This paper depicts some of the ways State and local governments define, regulate, and police the communities and markets where consumers convert their income into a way of life. Explained are how regulatory processes are developed in State and local government, what the underlying concepts are, and some of the access points for fruitful citizen…

  14. 76 FR 11985 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property AGENCY: Defense Acquisition... expand reporting requirements for Government-furnished property to include items uniquely and non....m. to 4 p.m. DST. DoD published a notice of the public meeting on March 1, 2011 (76 FR 11190)....

  15. 76 FR 9527 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Regulation Supplement; Reporting of Government-Furnished Property (DFARS Case 2009-D043) AGENCY: Defense...) to revise and expand reporting requirements for Government-furnished property to include items.... Background DoD published a proposed rule in the Federal Register on December 22, 2010 (75 FR 80426), with...

  16. 75 FR 3395 - Migratory Bird Permits; Changes in the Regulations Governing Falconry

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF THE INTERIOR Fish and Wildlife Service 50 CFR Parts 21 and 22 RIN 1018-AW44 Migratory Bird Permits; Changes in the Regulations Governing Falconry Correction In rule document 2010-12 beginning on page 927 in the issue...

  17. Cell fate regulation governed by a repurposed bacterial histidine kinase

    DOE PAGES

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interactionmore » between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.« less

  18. Cell fate regulation governed by a repurposed bacterial histidine kinase

    SciTech Connect

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.

  19. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2) Inshell... programs, and diversion to animal feed or oil manufacture, but such walnuts shall be subject to the... provisions of this regulation is subject to a forfeiture in the amount prescribed in section 608a(5) of...

  20. Governing childhood obesity: framing regulation of fast food advertising in the Australian print media.

    PubMed

    Henderson, Julie; Coveney, John; Ward, Paul; Taylor, Anne

    2009-11-01

    Childhood obesity is widely constructed as reaching epidemic proportions with consumption of fast food viewed as a contributing factor. This paper analyses media reporting of the regulation of fast food consumption to children. A media search of five Australian newspapers for the period January 2006 to June 2008 elicited 100 articles relating to the regulation of fast food advertising to children. Content and thematic analysis of the articles reveal conflicting perspectives on the role of the state; the level of accountability of the food and advertising industries; and responsibilities of parents for regulating fast food consumption in children. The Federal Government, food and advertising industries and free to air broadcasters favour industry self-regulation and personal responsibility for fast food consumption while the proponents of government regulation include consumer groups, state government health ministers, nutrition and public health academics and medical and health foundations. The regulation of fast food advertising to children is discussed in relation to ideas about governance and the public health strategies which follow from these ideas. The paper argues that all proposed solutions are indicative of a neoliberal approach to the governance of health insofar as the responsibility for regulation of food marketing is viewed as lying with industry and the regulation of lifestyle risk is viewed as an individual responsibility.

  1. Governing childhood obesity: framing regulation of fast food advertising in the Australian print media.

    PubMed

    Henderson, Julie; Coveney, John; Ward, Paul; Taylor, Anne

    2009-11-01

    Childhood obesity is widely constructed as reaching epidemic proportions with consumption of fast food viewed as a contributing factor. This paper analyses media reporting of the regulation of fast food consumption to children. A media search of five Australian newspapers for the period January 2006 to June 2008 elicited 100 articles relating to the regulation of fast food advertising to children. Content and thematic analysis of the articles reveal conflicting perspectives on the role of the state; the level of accountability of the food and advertising industries; and responsibilities of parents for regulating fast food consumption in children. The Federal Government, food and advertising industries and free to air broadcasters favour industry self-regulation and personal responsibility for fast food consumption while the proponents of government regulation include consumer groups, state government health ministers, nutrition and public health academics and medical and health foundations. The regulation of fast food advertising to children is discussed in relation to ideas about governance and the public health strategies which follow from these ideas. The paper argues that all proposed solutions are indicative of a neoliberal approach to the governance of health insofar as the responsibility for regulation of food marketing is viewed as lying with industry and the regulation of lifestyle risk is viewed as an individual responsibility. PMID:19758736

  2. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  3. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  4. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  5. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  6. 5 CFR 2421.3 - National consultation rights; consultation rights on Government-wide rules or regulations...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; consultation rights on Government-wide rules or regulations; exclusive recognition; unfair labor practices... SUBCHAPTER § 2421.3 National consultation rights; consultation rights on Government-wide rules or regulations... in 5 U.S.C. 7113; (b) Consultation rights on Government-wide rules or regulations has the meaning...

  7. 43 CFR 1812.1-1 - Regulations governing practice before the Department.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Department. 1812.1-1 Section 1812.1-1 Public Lands: Interior Regulations Relating to Public Lands (Continued... GUIDANCE Qualifications of Practitioners § 1812.1-1 Regulations governing practice before the Department..., must comply with the requirements of part 1 of this title....

  8. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What types of geothermal operations are... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.10 What types of geothermal operations are governed by these utilization regulations? (a) The regulations...

  9. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What types of geothermal operations are... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.10 What types of geothermal operations are governed by these utilization regulations? (a) The regulations...

  10. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What types of geothermal operations are... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.10 What types of geothermal operations are governed by these utilization regulations? (a) The regulations...

  11. Recent hospital charity care controversies highlight ambiguities and outdated features of government regulations.

    PubMed

    MacKelvie, Charles; Apolskis, Michael; Unland, James J

    2005-01-01

    For years the hospital industry has been embroiled in controversies involving pricing, charity care, and collection practices. Unfortunately, Medicare regulations and policies governing hospital charge-setting and collection practices have not helped bring much clarity to the situation, nor has related CMS and OIG guidance. Coordinated effort by hospitals and regulatory bodies can help clarify unclear government regulation of charity care, pricing, and collections and end potentially destructive controversies that sap valuable time, energy, and resources from efforts addressing much graver long-term threats to hospital viability.

  12. 75 FR 2126 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... Federal Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre... season for an Alaska Natural Gas Transportation Project. The Workshop is being hosted by the...

  13. 75 FR 6370 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre-Filing Workshop... hold a workshop on the procedures and process for holding and commenting on an open season for...

  14. 75 FR 22729 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Government property to the DCMA ``eTools'' application. ] DATES: Comments on the proposed rule should be... of the following methods: Federal eRulemaking Portal: http://www.regulations.gov . Follow the instructions for submitting comments. E-mail: dfars@osd.mil . Include DFARS Case 2008-D049 in the subject...

  15. 32 CFR 700.857 - Safe navigation and regulations governing operation of ships and aircraft.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of lights or other safeguards against collision. Except in time of actual armed conflict, such... matters shall be promulgated by the Chief of Naval Operations. (c) Professional standards and regulations governing the operation of naval aircraft and related matters shall be promulgated by the Chief of...

  16. 32 CFR 700.857 - Safe navigation and regulations governing operation of ships and aircraft.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of lights or other safeguards against collision. Except in time of actual armed conflict, such... matters shall be promulgated by the Chief of Naval Operations. (c) Professional standards and regulations governing the operation of naval aircraft and related matters shall be promulgated by the Chief of...

  17. 32 CFR 700.857 - Safe navigation and regulations governing operation of ships and aircraft.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of lights or other safeguards against collision. Except in time of actual armed conflict, such... matters shall be promulgated by the Chief of Naval Operations. (c) Professional standards and regulations governing the operation of naval aircraft and related matters shall be promulgated by the Chief of...

  18. 75 FR 8329 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... comments. Absent unusual circumstances, FERC will act on the open season plan within 60 days of its... Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Rescheduled Alaska Natural Gas Transportation Projects Open Season...

  19. 75 FR 29917 - Migratory Bird Permits; Changes in the Regulations Governing Migratory Bird Rehabilitation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... FR 61123) to establish regulations for the issuance of permits to rehabilitate migratory birds in the... Relations with Native American Tribal Governments'' (59 FR 22951), Executive Order 13175, and 512 DM 2, we... Fish and Wildlife Service 50 CFR Part 21 RIN 1018-AX09 Migratory Bird Permits; Changes in...

  20. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Responsibilities of Government and Special Government Employees E Appendix E to Part 99 Transportation Office of... Employees Note: This appendix applies only to employees who terminated government service before January 1... integrity of the services which the Government may expect from such officer or employee, or (2) if,...

  1. Options for state and local governments to regulate non-cigarette tobacco products.

    PubMed

    Freiberg, Michael

    2012-01-01

    Most tobacco control laws were written to address the scourge of smoking--particularly smoking cigarettes. As a result, these laws frequently exclude non-cigarette tobacco products, which are becoming more prevalent on the market. These regulatory gaps jeopardize public health by increasing the possibility that these products will be used--particularly by minors and young adults. This article examines gaps in regulation using five products as case studies: dissolvable tobacco products, electronic cigarettes, little cigars, snus, and water pipes. In addition, this article presents policy options that state and local governments can adopt to regulate these products more effectively, including regulations relating to price, flavors, youth access, use in public places, point-of-sale warnings, and marketing. Furthermore, this article contains extensive discussion of the recently adopted federal Family Smoking Prevention and Tobacco Control Act, which both limits and expands the power of state and local governments.

  2. Limiting the Influence of Pharmaceutical Industry Gifts on Physicians: Self-Regulation or Government Intervention?

    PubMed Central

    2009-01-01

    Concerns over the influence of pharmaceutical gifts on physicians have surged in recent years. This has prompted wide ranging legislative proposals in numerous states and in the federal government as well as stepped up efforts at self-regulation by the pharmaceutical industry and the medical profession. Policymakers face the decision of whether to defer to self-regulation or support government intervention. This commentary describes efforts at self-regulation by the pharmaceutical industry and the medical profession. The author examines and critiques the wide ranging legislative strategies pursued to limit the influence of pharmaceutical gifts on physicians and concludes with suggestions for policymakers and the profession to limit influence and preserve public trust. PMID:19756874

  3. Regulations governing the out-of-state practice of psychology: implications for forensic neuropsychologists.

    PubMed

    Yantz, Christine L; Bauer, Lyndsey; McCaffrey, Robert J

    2006-01-01

    Many states allow psychologists licensed in other jurisdictions to practice temporarily without obtaining a full license. However, both the restrictions of practice and the procedures required before practice is allowed vary extensively among states. This article examines the regulations of U.S. and Canadian territories governing temporary practice of nonresident psychologists. Current licensing laws were obtained from each state's respective psychological board or related Web sites from May to July 2004. Results highlighted vast regulatory and procedural differences for temporary practice among jurisdictions. Due to the degree of variability in each jurisdiction's regulations governing, caution must be taken so that psychologists comply with up-to-date guidelines before practicing outside of the regions in which they are licensed. The out-of-state psychologist must contact the appropriate state or provincial licensing board for guidelines and pertinent regulation.

  4. Government can regulate food advertising to children because cognitive research shows that it is inherently misleading.

    PubMed

    Graff, Samantha; Kunkel, Dale; Mermin, Seth E

    2012-02-01

    The childhood obesity crisis has prompted repeated calls for government action to curb the marketing of unhealthy food to children. Food and entertainment industry groups have asserted that the First Amendment prohibits such regulation. However, case law establishes that the First Amendment does not protect "inherently misleading" commercial speech. Cognitive research indicates that young children cannot effectively recognize the persuasive intent of advertising or apply the critical evaluation required to comprehend commercial messages. Given this combination--that government can prohibit "inherently misleading" advertising and that children cannot adequately understand commercial messages--advertising to children younger than age twelve should be considered beyond the scope of constitutional protection. PMID:22323170

  5. Participatory health impact assessment for the development of local government regulation on hazard control

    SciTech Connect

    Inmuong, Uraiwan; Rithmak, Panee; Srisookwatana, Soomol; Traithin, Nathathai; Maisuporn, Pornpun

    2011-07-15

    The Thai Public Health Act 1992 required the Thai local governments to issue respective regulations to take control of any possible health-hazard related activities, both from commercial and noncommercial sources. Since 1999, there has been centrally decentralized of power to a new form of local government establishment, namely Sub-district Administrative Organization (SAO). The SAO is asmall-scale local governing structure while its legitimate function is for community services, including control of health impact related activities. Most elected SAO administrators and officers are new and less experience with any of public health code of practice, particularly on health-hazard control. This action research attempted to introduce and apply a participatory health impact assessment (HIA) tool for the development of SAO health-hazard control regulation. The study sites were at Ban Meang and Kok See SAOs, Khon Kaen Province, Thailand, while all intervention activities conducted during May 2005-April 2006. A set of cooperative activities between researchers and community representatives were planned and organized by; surveying and identifying place and service base locally causing local environmental health problems, organizing community participatory workshops for drafting and proposing the health-hazard control regulation, and appropriate practices for health-hazard controlling measures. This action research eventually could successfully enable the SAO administrators and officers understanding of local environmental-related health problem, as well as development of imposed health-hazard control regulation for local community.

  6. United States Government Regulations and International Standards Related to Food Analysis

    NASA Astrophysics Data System (ADS)

    Nielsen, S. Suzanne

    Knowledge of government regulations relevant to the chemical analysis of foods is extremely important to persons working in the food industry. Federal laws and regulations reinforce the efforts of the food industry to provide wholesome foods, to inform consumers about the nutritional composition of foods, and to eliminate economic frauds. In some cases, they dictate what ingredients a food must contain, what must be tested, and the procedures used to analyze foods for safety factors and quality attributes. This chapter describes the US federal regulations related to the composition of foods. The reader is referred to references (1-4) for comprehensive coverage of US food laws and regulations. Many of the regulations referred to in this chapter are published in the various titles of the Code of Federal Regulations (CFR) (5). This chapter also includes information about food standards and safety practices established by international organizations. Internet addresses are given at the end of this chapter for many of the government agencies, organizations, and documents discussed.

  7. 76 FR 11985 - Acquisition Regulation: Department of Energy Acquisition Regulation, Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... Property. On May 15, 2007 (72 FR 27364), in the Federal Acquisition Circular (FAC) 2005-17, FAR Part 45 was... [65 FR 13735]. DOE has examined the proposed rule and has determined that it does not preempt State... Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use, [66 FR 28355, May...

  8. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Inclusion as a disabled child in the employee's annuity rate under the social security overall minimum. (2... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When...

  9. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulated articles from quarantined areas. 301.51-4 Section 301.51-4 Agriculture Regulations of the... DOMESTIC QUARANTINE NOTICES Asian Longhorned Beetle § 301.51-4 Conditions governing the interstate movement of regulated articles from quarantined areas. (a) Any regulated article may be moved interstate...

  10. Impact of government regulations on leadtimes of coal facilities. Final report

    SciTech Connect

    Singh, J.; Carboni, J.V.; Shah, D.V.; White, J.M. Jr.

    1980-08-01

    The ability of the US to increase coal use depends on the leadtimes required to bring from inception into operation: (1) new coal use facilities such as powerplants, industrial boilers, coke ovens, and coal-based synfuel plants; and (2) new coal facilities including surface mines, deep mines, coal preparation plants, and railroad lines. This study examines the effect of government regulations on the leadtimes for the following ten facilities: surface mines on federal land; surface mines - private surface/private coal; underground coal mines; coal preparation plants; railroad lines; coal-fired electric generating plants; coal-fired industrial facilities; coke plants; synthetic fuels; and transmission lines. Environmental activities consume a significant portion of critical path time for all facilities. The time spent for obtaining permits and licenses account for as much as 63% of total critical path time in the case of a new railroad line servicing a coal mine in the western US. For surface mines, permitting accounts for 33% of total project critical path; for underground mines, it is 43%. Permitting requires 26 and 42% of the critical paths for new industrial facilities and power plants, respectively. Long durations of critical environmental activities account for much of the uncertainty surrounding the approval of large coal projects. Government regulations have also affected the way companies conduct their business. Dealing with government regulations has become as important to the completion of new coal facilities as project financing, design, and construction.

  11. Government regulation of gambling advertising: Replacing vice prevention with consumer protection.

    PubMed

    Rothman, M; Robbins, H

    1991-12-01

    From 1895 to 1975, federal law forbade gambling advertising by use of the mail, interstate commerce, and the broadcast media. Congress exempted state lotteries in 1975 and charitable gambling (including casino games) in 1988. However, the Supreme Court requires a significant government interest, directly applied and narrowly tailored, in order to justify a commercial speech regulation. The exemptions for private charity casino games has arguably destroyed any constitutionally defensible government interest in restricting for-profit casinos. Casinos in new gambling jurisdictions (such as Iowa or Illinois) will probably push the hardest for an exemption for all legal gambling, as they have the most to gain from the freedom to advertise. Federal regulation of gambling advertising will fall to the Federal Trade Commission under prohibitions against "unfair or deceptive" trade practices. But as State regulations are not well developed even in states that permit casino gambling, there is a pressing need for new research to review state laws regulating gambling advertising and to propose a model statute. PMID:24243220

  12. 75 FR 54527 - Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... Defense Acquisition Regulations System 48 CFR Parts 227 and 252 RIN 0750-AG50 Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels (DFARS Case 2008-D039) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is adopting...

  13. [Changes in the regulation and government of the health system. SESPAS report 2014].

    PubMed

    Repullo, José R

    2014-06-01

    The economic and fiscal crisis of 2008 has erupted into the debate on the sustainability of health systems; some countries, such as Spain, have implemented strong policies of fiscal consolidation and austerity. The institutional framework and governance model of the national health system (NHS) after its devolution to regions in 2002 had significant weaknesses, which were not apparent in the rapid growth stage but which have been clearly visible since 2010. In this article, we describe the changes in government regulation from the national and NHS perspective: both general changes (clearly prompted by the economic authorities), and those more specifically addressed to healthcare. The Royal Decree-Law 16/2012 represents the centerpiece of austerity policies in healthcare but also implies a rupture with existing political consensus and a return to social security models. Our characterization of austerity in healthcare explores impacts on savings, services, and on the healthcare model itself, although the available information only allows some indications. The conclusions highlight the need to change the path of linear, rapid and radical budget cuts, providing a time-frame for implementing key reforms in terms of internal sustainability; to do so, it is appropriate to restore political and institutional consensus, to emphasize "clinical management" and divestment of inappropriate services (approach to the medical profession and its role as micro-manager), and to create frameworks of good governance and organizational innovations that support these structural reforms.

  14. [Changes in the regulation and government of the health system. SESPAS report 2014].

    PubMed

    Repullo, José R

    2014-06-01

    The economic and fiscal crisis of 2008 has erupted into the debate on the sustainability of health systems; some countries, such as Spain, have implemented strong policies of fiscal consolidation and austerity. The institutional framework and governance model of the national health system (NHS) after its devolution to regions in 2002 had significant weaknesses, which were not apparent in the rapid growth stage but which have been clearly visible since 2010. In this article, we describe the changes in government regulation from the national and NHS perspective: both general changes (clearly prompted by the economic authorities), and those more specifically addressed to healthcare. The Royal Decree-Law 16/2012 represents the centerpiece of austerity policies in healthcare but also implies a rupture with existing political consensus and a return to social security models. Our characterization of austerity in healthcare explores impacts on savings, services, and on the healthcare model itself, although the available information only allows some indications. The conclusions highlight the need to change the path of linear, rapid and radical budget cuts, providing a time-frame for implementing key reforms in terms of internal sustainability; to do so, it is appropriate to restore political and institutional consensus, to emphasize "clinical management" and divestment of inappropriate services (approach to the medical profession and its role as micro-manager), and to create frameworks of good governance and organizational innovations that support these structural reforms. PMID:24863996

  15. AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

    PubMed Central

    Young, Nathan P.; Kamireddy, Anwesh; Van Nostrand, Jeanine L.; Eichner, Lillian J.; Shokhirev, Maxim Nikolaievich; Dayn, Yelena; Shaw, Reuben J.

    2016-01-01

    Faithful execution of developmental programs relies on the acquisition of unique cell identities from pluripotent progenitors, a process governed by combinatorial inputs from numerous signaling cascades that ultimately dictate lineage-specific transcriptional outputs. Despite growing evidence that metabolism is integrated with many molecular networks, how pathways that control energy homeostasis may affect cell fate decisions is largely unknown. Here, we show that AMP-activated protein kinase (AMPK), a central metabolic regulator, plays critical roles in lineage specification. Although AMPK-deficient embryonic stem cells (ESCs) were normal in the pluripotent state, these cells displayed profound defects upon differentiation, failing to generate chimeric embryos and preferentially adopting an ectodermal fate at the expense of the endoderm during embryoid body (EB) formation. AMPK−/− EBs exhibited reduced levels of Tfeb, a master transcriptional regulator of lysosomes, leading to diminished endolysosomal function. Remarkably, genetic loss of Tfeb also yielded endodermal defects, while AMPK-null ESCs overexpressing this transcription factor normalized their differential potential, revealing an intimate connection between Tfeb/lysosomes and germ layer specification. The compromised endolysosomal system resulting from AMPK or Tfeb inactivation blunted Wnt signaling, while up-regulating this pathway restored expression of endodermal markers. Collectively, these results uncover the AMPK pathway as a novel regulator of cell fate determination during differentiation. PMID:26944679

  16. From Hippocrates to Commodities: three models of NHS governance: NHS governance, regulation, Mid Staffordshire inquiry, health care as a commodity.

    PubMed

    Newdick, Christopher

    2014-01-01

    A series of inquiries and reports suggest considerable failings in the care provided to some patients in the NHS. Although the Bristol Inquiry report of 2001 led to the creation of many new regulatory bodies to supervise the NHS, they have never enjoyed consistent support from government and the Mid Staffordshire Inquiry in 2013 suggests they made little difference. Why do some parts of the NHS disregard patients' interests and how we should we respond to the challenge? The following discusses the evolution of approaches to NHS governance through the Hippocratic, Managerial and Commercial models, and assesses their risks and benefits. Apart from the ethical imperative, the need for effective governance is driven both by the growth in information available to the public and the resources wasted by ineffective systems of care. Appropriate solutions depend on an understanding of the perverse incentives inherent in each model and the need for greater sensitivity to the voices of patients and the public. PMID:24841525

  17. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Golden Nematode Quarantine and Regulations § 301.85-3 Conditions governing the... of the golden nematode and the person in possession thereof has been so notified; or (v) Through or... golden nematode exists; or (v) Through or reshipped from any regulated area if the articles...

  18. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  19. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  20. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  1. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  2. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on...

  3. 76 FR 11363 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ...). In addition, these same requirements are also appropriate for adaptation to the corresponding DFARS... Government support contractor. This requires adaptation of the current DFARS coverage governing...

  4. 75 FR 52459 - Regulations Governing Agencies for Issue of United States Savings Bonds; Offering of United...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ..., Electronic funds transfers, Federal Reserve System, Government securities, Securities. 31 CFR Part 351 Bonds, Federal Reserve System, Government securities. 31 CFR Part 353 Banks and banking, Government securities, Federal Reserve system. 31 CFR Part 359 Bonds, Federal Reserve system, Government securities,...

  5. 76 FR 71823 - Defense Federal Acquisition Regulation Supplement: Responsibility and Liability for Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Government's general practice of self-insuring its risks of loss or damage to Government-furnished property... Government-furnished property on all firm-fixed-price contracts, which is outside the scope of this rule. The proposed rule did not address the provision of, or need for, Government-furnished property, but...

  6. 75 FR 25160 - Defense Federal Acquisition Regulation Supplement; Marking of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... Supplement; Marking of Government-Furnished Property (DFARS Case 2008-D050) AGENCY: Defense Acquisition...-furnished property identified in the contract when the Government-furnished material and Government.... The proposed clause requires contractors who are provided Government-furnished property to tag,...

  7. Private governance, public purpose? Assessing transparency and accountability in self-regulation of food advertising to children.

    PubMed

    Reeve, Belinda

    2013-06-01

    Reducing non-core food advertising to children is an important priority in strategies to address childhood obesity. Public health researchers argue for government intervention on the basis that food industry self-regulation is ineffective; however, the industry contends that the existing voluntary scheme adequately addresses community concerns. This paper examines the operation of two self-regulatory initiatives governing food advertising to children in Australia, in order to determine whether these regulatory processes foster transparent and accountable self-regulation. The paper concludes that while both codes appear to establish transparency and accountability mechanisms, they do not provide for meaningful stakeholder participation in the self-regulatory scheme. Accordingly, food industry self-regulation is unlikely to reflect public health concerns or to be perceived as a legitimate form of governance by external stakeholders. If industry regulation is to remain a feasible alternative to statutory regulation, there is a strong argument for strengthening government oversight and implementing a co-regulatory scheme.

  8. Private governance, public purpose? Assessing transparency and accountability in self-regulation of food advertising to children.

    PubMed

    Reeve, Belinda

    2013-06-01

    Reducing non-core food advertising to children is an important priority in strategies to address childhood obesity. Public health researchers argue for government intervention on the basis that food industry self-regulation is ineffective; however, the industry contends that the existing voluntary scheme adequately addresses community concerns. This paper examines the operation of two self-regulatory initiatives governing food advertising to children in Australia, in order to determine whether these regulatory processes foster transparent and accountable self-regulation. The paper concludes that while both codes appear to establish transparency and accountability mechanisms, they do not provide for meaningful stakeholder participation in the self-regulatory scheme. Accordingly, food industry self-regulation is unlikely to reflect public health concerns or to be perceived as a legitimate form of governance by external stakeholders. If industry regulation is to remain a feasible alternative to statutory regulation, there is a strong argument for strengthening government oversight and implementing a co-regulatory scheme. PMID:23585017

  9. 75 FR 33796 - Federal Acquisition Regulation; Submission for OMB Review; Government Property; OMB Control No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... Government- ] furnished property and contractor-acquired property. Contractors are required to establish and... Government Property. A notice was published in the Federal Register at 75 FR 17410, on April 6, 2010....

  10. 76 FR 59592 - Government Securities Act Regulations; Replacement of References to Credit Ratings and Technical...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... of ``credit risk haircuts'' and ``market risk haircuts'' calculated by each government securities... credit risk as reasonably determined by the government securities broker or dealer pursuant to written... making an assessment of credit and liquidity risk, the government securities broker or dealer...

  11. 75 FR 33734 - Regulations Affecting Publication of the United States Government Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... transferred to the Office of the Federal Register from the Office of Government Reports within the Bureau of... From the Federal Register Online via the Government Publishing Office #0; #0;Proposed Rules #0... the United States Government Manual AGENCY: Administrative Committee of the Federal Register....

  12. 75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... the contract). One respondent recommended revision of the definition of Government Furnished Property... include ``Government-furnished property also includes contractor-acquired property if the contractor... FAR 45.101 and 52.245-1 to clarify the definition of ``Government-furnished property.'' Revised FAR...

  13. 78 FR 1562 - Improving Government Regulations; Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... of Government-Furnished Property (DFARS Case 2012-D001) Legal Authority: 41 U.S.C. 1303 Abstract: DoD... requirements for Government-furnished property to include items uniquely and non- uniquely identified. The... of Government-Furnished Property,'' and is being revised to expand definitions, and provide...

  14. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and... Act of 1964 (42 U.S.C. 2000d, et seq.) as implemented by DOE regulations at 10 CFR part 1040. These... Discrimination Act of 1975 (42 U.S.C. 6101, et seq.) as implemented by DOE regulations at 10 CFR part 1040....

  15. Impact of government regulations on leadtimes of coal facilities. Final report

    SciTech Connect

    Not Available

    1980-08-01

    The ability of the US to increase coal use depends on the leadtimes required to bring from inception into operation: (1) new coal use facilities such as powerplants, industrial boilers, coke ovens, and coal-based synfuel plants; and (2) new coal facilities including surface mines, deep mines, coal preparation plants, and railroad lines. This study examines the effect of government regulations on the leadtimes for the following ten facilities: surface mines on federal land; surface mines - private surface/private coal; underground coal mines; coal preparation plants; railroad lines; coal-fired electric generating plants; coal-fired industrial facilities; coke plants; synthetic fuels; and transmission lines. These appendices contain summaries of legislation affecting the above coal facilities. Discussed are: the Clean Air Act; National Environmental Policy Act; Federal Coal Leasing Amendments Act; Surface Mining Control and Reclamation Act; Federal Land Policy and Management Act; River and Harbors Act; Federal Mine Health and Safety Amendments Act; Fish and Wildlife Coordination Act; National Historic Preservation Act; Endangered Species Act; the Clear Water Act; and the Resource Conservation and Recovery Act. (DMC)

  16. Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression

    PubMed Central

    Chen, Chider; Akiyama, Kentaro; Yamaza, Takayoshi; You, Yong-Ouk; Xu, Xingtian; Li, Bei; Zhao, Yimin; Shi, Songtao

    2014-01-01

    Bone marrow mesenchymal stem cells (BMMSCs) are capable of differentiating into multiple cell types and regulating immune cell response. However, the mechanisms that govern the immunomodulatory properties of BMMSCs are still not fully elucidated. Here we show that telomerase-deficient BMMSCs lose their capacity to inhibit T cells and ameliorate the disease phenotype in systemic sclerosis mice. Restoration of telomerase activity by telomerase reverse transcriptase (TERT) transfection in TERT−/− BMMSCs rescues their immunomodulatory functions. Mechanistically, we reveal that TERT, combined with β-catenin and BRG1, serves as a transcriptional complex, which binds the FAS ligand (FASL) promoter to upregulate FASL expression, leading to an elevated immunomodulatory function. To test the translational value of these findings in the context of potential clinical therapy, we used aspirin treatment to upregulate telomerase activity in BMMSCs, and found a significant improvement in the immunomodulatory capacity of BMMSCs. Taken together, these findings identify a previously unrecognized role of TERT in improving the immunomodulatory capacity of BMMSCs, suggesting that aspirin treatment is a practical approach to significantly reduce cell dosage in BMMSC-based immunotherapies. Subject Categories Stem Cells; Immunology PMID:24401839

  17. The Regulation of Peace River: a Large-scale Experiment on Fluvial Governing Conditions

    NASA Astrophysics Data System (ADS)

    Church, M.

    2004-12-01

    In 1967, British Columbia Hydro and Power Authority closed W.A.C.Bennett Dam, creating what was then the sixth largest hydropower project in the world. The dam is located in the Rocky Mountain front range so that, although it controls about half the runoff of the 293 000 sq.km basin, almost all of the sediment load originates downstream from the dam in the Alberta Plateau. Hence, the effects of these two principal governing conditions of fluvial systems can be separated. The 378 km immediately downstream to the Smoky River confluence are a wandering, cobble-gravel reach It has effectively ceased to be alluvial and the channel pattern has been simplified. Aggradation is occurring at major tributary junctions, whilst the tributaries themselves have degraded in their lowermost reaches. Smoky River, the principal tributary, delivers a large sand load. The 250 km reach to Carcajou is sandy gravel and the final 600 km to the Peace-Athabasca delta is sand-bed. Aggradation, with a change in fluvial style toward low-order braiding, appears to be underway in the proximal sand-bed reach. More generally, channel shrinkage in response to the regulated flow regime is controlled by the rate of progradation of riparian vegetation onto former bar surfaces In 1996, after 29 years of regulated flow, reservoir drawdown for dam repairs led to full spillway flows for 8 consecutive weeks, creating an effectively bankfull condition in the proximal post-regulation channel. Significant degradation was observed for the first time in many cross-sections but overall changes were surprisingly modest, reflecting the refractory bed and the degree to which riparian vegetation has become firmly established in former channel areas. Overall, sediment supply and flow competence are the principal controls of fluvial response in the system. The experimental aspect of this study of a large, northward flowing, boreal river can be controlled by before-after comparison. However, this strategy must take into

  18. Health and social care regulation in Wales: an integrated system of political, corporate and professional governance for improving public health.

    PubMed

    Jewell, Tony; Wilkinson, Jane

    2008-11-01

    Wales is developing a unique integrated system of governance to improve public health, which is diverging from some recent developments in the rest of the UK but shares many common features. There is a focus on strengthening collaborative working and co-ordination between bodies inspecting, regulating and auditing health and social care. Systems are being developed that are proportionate to the level of risk, eliminate unnecessary burdens of external review and support the improvement of services for patients, service users and carers. This is consistent with the Assembly Government's aim to improve the way that public services are delivered in Wales, including strengthening input from the public in the planning, delivery and reporting of regulation and inspection work. The test in the future will be how far we can demonstrate quantitatively and qualitatively the added value from our uniquely Welsh approach, built as it is on devolution and the aspirations for small-country governance. PMID:19058471

  19. Health and social care regulation in Wales: an integrated system of political, corporate and professional governance for improving public health.

    PubMed

    Jewell, Tony; Wilkinson, Jane

    2008-11-01

    Wales is developing a unique integrated system of governance to improve public health, which is diverging from some recent developments in the rest of the UK but shares many common features. There is a focus on strengthening collaborative working and co-ordination between bodies inspecting, regulating and auditing health and social care. Systems are being developed that are proportionate to the level of risk, eliminate unnecessary burdens of external review and support the improvement of services for patients, service users and carers. This is consistent with the Assembly Government's aim to improve the way that public services are delivered in Wales, including strengthening input from the public in the planning, delivery and reporting of regulation and inspection work. The test in the future will be how far we can demonstrate quantitatively and qualitatively the added value from our uniquely Welsh approach, built as it is on devolution and the aspirations for small-country governance.

  20. Fifty Educational Markets: A Playbook of State Laws and Regulations Governing Private Schools. School Choice Issues in Depth

    ERIC Educational Resources Information Center

    Hammons, Christopher

    2008-01-01

    There is a widespread misperception that private schools avoid government oversight or are "unregulated." In fact, private schools are subject to a wide variety of laws and regulations that run the gamut from reasonable rules to ensure health and safety to unreasonable rules that interfere with school curricula, preventing schools from pursuing…

  1. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts...

  2. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  3. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  4. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts A... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be...

  5. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to the United States. 251.14 Section 251.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND...

  6. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  7. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  8. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  9. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  10. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  11. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered compatible? States are not required to adopt 49 CFR parts 398 and 399, subparts...

  12. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 251.15 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... shall be cause for revocation of all rights to use, occupy, or disturb the surface of the lands...

  13. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 251.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.14 Conditions, rules and regulations to govern exercise... paragraphs (b) and (c) of this section, in conveyance of lands to the United States under authorized...

  14. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 251.15 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... permit shall be cause for termination of all rights to use, occupy, or disturb the surface of the...

  15. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 251.15 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... shall be cause for revocation of all rights to use, occupy, or disturb the surface of the lands...

  16. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 251.15 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... permit shall be cause for termination of all rights to use, occupy, or disturb the surface of the...

  17. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 251.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.14 Conditions, rules and regulations to govern exercise... paragraphs (b) and (c) of this section, in conveyance of lands to the United States under authorized...

  18. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 251.14 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.14 Conditions, rules and regulations to govern exercise... paragraphs (b) and (c) of this section, in conveyance of lands to the United States under authorized...

  19. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 251.15 Parks, Forests, and Public Property FOREST SERVICE, DEPARTMENT OF AGRICULTURE LAND USES Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... permit shall be cause for termination of all rights to use, occupy, or disturb the surface of the...

  20. 7 CFR 301.50-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Pine Shoot Beetle § 301.50-4 Conditions governing the interstate movement of... beetle; and (2) The point of origin of the regulated article is indicted on the waybill. (c) With a... permit, which the Administrator has found to be adequate to prevent the spread of the pine shoot...

  1. 7 CFR 301.50-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Pine Shoot Beetle § 301.50-4 Conditions governing the interstate movement of... beetle; and (2) The point of origin of the regulated article is indicted on the waybill. (c) With a... permit, which the Administrator has found to be adequate to prevent the spread of the pine shoot...

  2. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  3. 7 CFR 301.50-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Pine Shoot Beetle § 301.50-4 Conditions governing the interstate movement of... beetle; and (2) The point of origin of the regulated article is indicted on the waybill. (c) With a... permit, which the Administrator has found to be adequate to prevent the spread of the pine shoot...

  4. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  5. 7 CFR 301.50-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Pine Shoot Beetle § 301.50-4 Conditions governing the interstate movement of... beetle; and (2) The point of origin of the regulated article is indicted on the waybill. (c) With a... permit, which the Administrator has found to be adequate to prevent the spread of the pine shoot...

  6. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  7. 78 FR 67004 - Removal of References to Credit Ratings in Certain Regulations Governing the Federal Home Loan Banks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Certain Regulations Governing the Federal Home Loan Banks, 78 FR 30784, 30786-87 (May 23, 2013... Proposed Rule, 78 FR 30784 (proposing amendments to 12 CFR part 1267, part 1269, and part 1270). In... Corporation, and the Federal Home Loan Banks, 76 FR 5292 (Jan. 31, 2011). \\10\\ See Proposed Rule, Federal...

  8. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., Department of Agriculture rules and rules of the Department of Interior at 50 CFR parts 10 through 24 and... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and... Act of 1964 (42 U.S.C. 2000d, et seq.) as implemented by DOE regulations at 10 CFR part 1040....

  9. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  10. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  11. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  12. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  13. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  14. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element.

    PubMed

    Qian, Yi; Yin, Chunyang; Chen, Yue; Zhang, Shuping; Jiang, Li; Wang, Fudi; Zhao, Meirong; Liu, Sijin

    2015-05-01

    Ferroportin (FPN) is the only known iron exporter in mammalian cells, and is universally expressed in most types of cells. FPN signaling plays a crucial role in maintaining iron homeostasis through governing the level of intracellular iron. Serum iron storage is conversely related with the estrogen level in the female bodies, and women in post-menopause are possibly subjected to iron retention. However, the potential effects of estrogen on iron metabolism are not clearly understood. Here, FPN mRNA transcription in all selected estrogen receptor positive (ER+) cells was significantly reduced upon 17β-estradiol (E2) treatment; and this inhibitory effect could be attenuated by ER antagonist tamoxifen. Likewise, in murine bone marrow-derived macrophages (BMDMs), FPN reduction with elevated intracellular iron (reflected by increased ferritin) was observed in response to E2; however, ferritin level barely responded to E2 in FPN-null BMDMs. The observation of inhibition of FPN mRNA expression was not replicated in ER(-) cells upon E2. A functional estrogen response element (ERE) was identified within the promoter of FPN, and this ERE was responsible for the suppressive effect of E2 on FPN expression. Moreover, ovariectomized (OVX) and sham-operated (SHAM) mice were used to further confirm the in vitro finding. The expression of hepatic FPN was induced in OVX mice, compared to that in the SHAM mice. Taken together, our results demonstrated that estrogen is involved in regulating FPN expression through a functional ERE on its promoter, providing additional insights into a vital role of estrogen in iron metabolism.

  15. Government regulation and public opposition create high additional costs for field trials with GM crops in Switzerland.

    PubMed

    Bernauer, Thomas; Tribaldos, Theresa; Luginbühl, Carolin; Winzeler, Michael

    2011-12-01

    Field trials with GM crops are not only plant science experiments. They are also social experiments concerning the implications of government imposed regulatory constraints and public opposition for scientific activity. We assess these implications by estimating additional costs due to government regulation and public opposition in a recent set of field trials in Switzerland. We find that for every Euro spent on research, an additional 78 cents were spent on security, an additional 31 cents on biosafety, and an additional 17 cents on government regulatory supervision. Hence the total additional spending due to government regulation and public opposition was around 1.26 Euros for every Euro spent on the research per se. These estimates are conservative; they do not include additional costs that are hard to monetize (e.g. stakeholder information and dialogue activities, involvement of various government agencies). We conclude that further field experiments with GM crops in Switzerland are unlikely unless protected sites are set up to reduce these additional costs.

  16. 76 FR 21852 - Defense Federal Acquisition Regulation Supplement; Responsibility and Liability for Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ...; Responsibility and Liability for Government Property (DFARS Case 2010-D018) AGENCY: Defense Acquisition... other than submission of certified cost or pricing data. FAR 45.104, Responsibility and liability for... read as follows: 245.104 Responsibility and liability for Government property. (a) In addition to...

  17. 77 FR 51026 - Federal Acquisition Regulation; Submission for OMB Review; Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ..., special test equipment, and agency-peculiar property. Government property includes both Government-furnished property and contractor-acquired property. Contractors are required to establish and maintain a... FR 18497, on April 4, 2011. No comments were received. Public comments are particularly invited...

  18. A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility.

    PubMed

    Williamson, Andrew J K; Pierce, Andrew; Jaworska, Ewa; Zhou, Cong; Aspinall-O'Dea, Mark; Lancashire, Lee; Unwin, Richard D; Abraham, Sheela A; Walker, Michael J; Cadecco, Sara; Spooncer, Elaine; Holyoake, Tessa L; Whetton, Anthony D

    2013-11-01

    CXCL12 governs cellular motility, a process deregulated by hematopoietic stem cell oncogenes such as p210-BCR-ABL. A phosphoproteomics approach to the analysis of a hematopoietic progenitor cell line treated with CXCL12 and the Rac 1 and 2 inhibitor NSC23766 has been employed to objectively discover novel mechanisms for regulation of stem cells in normal and malignant hematopoiesis. The proteomic data sets identified new aspects of CXCL12-mediated signaling and novel features of stem cell regulation. We also identified a novel phosphorylation event in hematopoietic progenitor cells that correlated with motile response and governed by the chemotactic factor CXCL12. The novel phosphorylation site on PTPRC/CD45; a protein tyrosine phosphatase, was validated by raising an antibody to the site and also using a mass spectrometry absolute quantification strategy. Site directed mutagenesis and inhibitor studies demonstrated that this single phosphorylation site governs hematopoietic progenitor cell and lymphoid cell motility, lies downstream from Rac proteins and potentiates Src signaling. We have also demonstrated that PTPRC/CD45 is down-regulated in leukemogenic tyrosine kinase expressing cells. The use of discovery proteomics has enabled further understanding of the regulation of PTPRC/CD45 and its important role in cellular motility in progenitor cells.

  19. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false What other regulations govern...

  20. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false What other regulations govern...

  1. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false What other regulations govern...

  2. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false What other regulations govern...

  3. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., and bonds? (a) 31 CFR part 356 governs the sale and issue of marketable book-entry Treasury securities... commercial book-entry system. (b) 31 CFR part 357 governs holding marketable book-entry Treasury bills, notes... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What other regulations govern...

  4. Governing through Prevent? Regulation and Contested Practice in State–Muslim Engagement

    PubMed Central

    O’Toole, Therese; Meer, Nasar; DeHanas, Daniel Nilsson; Jones, Stephen H; Modood, Tariq

    2016-01-01

    In this article, we consider the implications of the ‘Prevent’ strand of the government’s counter-terrorism strategy for the UK state’s engagement with Muslims. We argue that the logics of Prevent have been highly problematic for state–Muslim engagement. Nevertheless, we suggest that the characterisation of state approaches to engaging Muslims as a form of discipline is incomplete without an analysis of: first, differences in practices, habits and perspectives across governance domains; second, variations in approach and implementation between levels of governance; and third, the agency of Muslims who engage with the state. Through this approach we show how attention to the situated practices of governance reveals the contested nature of governing through Prevent. PMID:26877558

  5. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  6. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  7. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  8. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  9. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have not been converted to book-entry bonds through New Treasury Direct. (b) The regulations in 31 CFR part 363... through New Treasury Direct. (c) The regulations in 31 CFR part 370 apply to transactions for the...

  10. 7 CFR 301.91-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... without stopping except under normal traffic conditions such as traffic lights or stop signs) any... of European larch canker; (ii) If the article originated outside of any regulated area; and (iii)...

  11. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  12. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  13. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  14. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  15. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  16. 26 CFR 1.892-3T - Income of foreign governments (temporary regulations).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... functional currency) or in precious metals when held by a foreign government or central bank of issue (as... when physically held by a central bank of issue. (5) Execution of financial or monetary policy—(i) Rule... ensure sufficient currency reserves, the monetary authority of foreign country FC issues...

  17. 26 CFR 1.892-3T - Income of foreign governments (temporary regulations).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... functional currency) or in precious metals when held by a foreign government or central bank of issue (as... when physically held by a central bank of issue. (5) Execution of financial or monetary policy—(i) Rule... ensure sufficient currency reserves, the monetary authority of foreign country FC issues...

  18. 7 CFR 999.1 - Regulation governing the importation of dates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... statement to that effect and the reasons therefor. governing imports of walnuts. (d)(1) Exemptions... not exceed 70 pounds and any dates that are so denatured as to render them unfit for human consumption... under the Plant Quarantine Act of 1912, the Federal Food, Drug, and Cosmetic Act, or any...

  19. TEQSA and Risk-Based Regulation: Considerations for University Governing Bodies

    ERIC Educational Resources Information Center

    Baird, Jeanette

    2013-01-01

    The advent of a new national regulatory and quality assurance regime in Australia, through the Tertiary Education Quality and Standards Agency (TEQSA), presents additional requirements to university governing bodies, for compliance with standards and for risk management. This paper discusses TEQSA's approach and potential vulnerabilities for…

  20. 78 FR 42921 - Amendments to Regulations Governing Ocean Transportation Intermediary Licensing and Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... Licensing and Financial Responsibility Requirements, and General Duties AGENCY: Federal Maritime Commission... Commission proposes to amend its rules governing the licensing, financial responsibility requirements and... Rulemaking, published on May 31, 2013 (78 FR 32946), are due on or before August 30, 2013. ADDRESSES:...

  1. 78 FR 32945 - Amendments to Regulations Governing Ocean Transportation Intermediary Licensing and Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 78 Friday, No. 105... establish a priority system to provide more protection for shippers. In order to provide better and more... 515.23(f) sets forth a mechanism for engaging the priority system established in sections...

  2. Roll-Out Neoliberalism and Hybrid Practices of Regulation in Australian Agri-Environmental Governance

    ERIC Educational Resources Information Center

    Lockie, Stewart; Higgins, Vaughan

    2007-01-01

    In the last 15 years, agri-environmental programmes in Australia have been underpinned by a neoliberal regime of governing which seeks to foster participation and "bottom-up" change at the regional level at the same time as encouraging farmers to become entrepreneurial and improve their productivity and environmental performance without government…

  3. An overview of federal laws and regulations governing ownership in and reimbursement for ambulatory surgical centers.

    PubMed

    Becker, Scott; Walsh, Amber McGraw

    2005-02-01

    This article has addressed certain of the key federal regulatory schemes governing ASCs with which owners and operators of ASCs should be familiar. In addition to the regulatory schemes addressed herein, we encourage owners and operators of ASCs to familiarize themselves with other critical requirements such as those relating to antitrust issues, taxation issues and state requirements regarding licensure, certification, ownership arrangements, and reimbursement.

  4. 77 FR 30998 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... work for foreign governments and international organizations. c. DFARS 245.604-3 concerns the sale of... officer to issue informal invitations for bid. Under paragraph (d), a contractor may be authorized by the... method, the contractor must submit to the plant clearance officer the informal bids received...

  5. 76 FR 6311 - Regulations Affecting Publication of the United States Government Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-04

    ... distributed to the general public and to officials of the Federal government in a print edition. 75 FR 33734... asked if any smart phone applications related to the Manual were under development and suggested that... Committee is not aware of any applications for smart phones currently under development. We hope that...

  6. Governing Education through Data in England: From Regulation to Self-Evaluation

    ERIC Educational Resources Information Center

    Ozga, Jenny

    2009-01-01

    This paper explores the relationship between changing forms of the governance of education and the growth and uses of data in the context of England--a context that can be described as the most "advanced" in Europe in terms of data production and use. The paper links the shifting relations between the central department of education (variously…

  7. 76 FR 21812 - Defense Federal Acquisition Regulation Supplement; Ownership or Control by a Foreign Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    .... SUPPLEMENTARY INFORMATION: I. Background DoD published an interim rule in the Federal Register at 75 FR 35684 on... or controlled by a foreign government. DoD published an interim rule in the Federal Register at 75 FR... 209 and 252 published at 75 FR 35684 on June 23, 2010, is adopted as final without change....

  8. 76 FR 72914 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Form 1637, Notice of Acceptance of Inventory Schedules; DD Form 1639, Scrap Warranty; DD Form 1640... following disposal determinations: (i) Downgrade useable property to scrap. (ii) Abandonment or destruction... schedules. (2) DD Form 1639, Scrap Warranty: When scrap is sold by the contractor, after Government...

  9. 78 FR 30233 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... Register at 76 FR 11363 on March 2, 2011, to implement section 821 of the National Defense Authorization... covered, including recognizing the inherent elements of a generic ``use'' that are expressly distinguished... information in the course of advising the Government on overall acquisition strategies. The...

  10. 76 FR 6006 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... comments on the proposed rule, which was published at 75 FR 22729 on April 30, 2010. Comments were due June... address the materiality of the loss and that without this information, decision makers may be misled and... reporting of the estimated harm or materiality of such losses to the Government. However, in order...

  11. 77 FR 22278 - Eagle Permits; Revisions to Regulations Governing Take Necessary To Protect Interests in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... eagles (74 FR 46836). Those regulations at 50 CFR 22.26 provide for permits to take bald eagles and... revisions to regulations under the Bald and Golden Eagle Protection Act for permits to take eagles where the...). Background The Bald and Golden Eagle Protection Act (16 U.S.C. 668-668d) (Eagle Act) prohibits take of......

  12. 76 FR 32285 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... periodically. The regulations were amended most recently on September 26, 2007 (TD 9359, 72 FR 54540), to...-138637-07) in the Federal Register (72 FR 54621) proposing to conform the professional standards under... Department published final regulations (TD 9436) in the Federal Register (73 FR 78430)...

  13. 78 FR 23194 - Federal Acquisition Regulation; Commercial and Government Entity Code

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... sponsored nation, from the NATO Maintenance and Supply Agency (NAMSA). The Federal procurement community... contractor personnel outside the United States; and Support supply chain traceability and integrity efforts...: Regulations.gov : http://www.regulations.gov . Submit comments via the Federal eRulemaking portal by...

  14. 78 FR 33994 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... Register on May 22, 2013, 78 FR 30233, regarding the Defense Federal Acquisition Regulation Supplement... May 22, 2013 (78 FR 30233) in the amendatory language, correct the following: 252.212-7001 0 1. On... Defense Acquisition Regulations System 48 CFR Part 252 RIN Number 0750-AG38 Defense Federal...

  15. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

    PubMed Central

    Laxmikanthan, Gurunathan; Xu, Chen; Brilot, Axel F; Warren, David; Steele, Lindsay; Seah, Nicole; Tong, Wenjun; Grigorieff, Nikolaus; Landy, Arthur; Van Duyne, Gregory D

    2016-01-01

    The molecular machinery responsible for DNA expression, recombination, and compaction has been difficult to visualize as functionally complete entities due to their combinatorial and structural complexity. We report here the structure of the intact functional assembly responsible for regulating and executing a site-specific DNA recombination reaction. The assembly is a 240-bp Holliday junction (HJ) bound specifically by 11 protein subunits. This higher-order complex is a key intermediate in the tightly regulated pathway for the excision of bacteriophage λ viral DNA out of the E. coli host chromosome, an extensively studied paradigmatic model system for the regulated rearrangement of DNA. Our results provide a structural basis for pre-existing data describing the excisive and integrative recombination pathways, and they help explain their regulation. DOI: http://dx.doi.org/10.7554/eLife.14313.001 PMID:27223329

  16. [Deceased organ donors, legal regulations governing diagnosis of brain death, overview of donors and liver transplants in the Czech Republic].

    PubMed

    Pokorná, E

    2013-08-01

    The key restriction of transplantation medicine globally, as well as in the Czech Republic, concerns the lack of organs. The number of deceased donors, and thus the availability of organ transplants, has been stagnating in our country. The paper describes current legal regulations governing the dia-gnosis of brain death and primary legal and medical criteria for the contraindication of the deceased for organ explantation, gives an overview of the number of liver transplants, age structure, and diagnosis resulting in brain death of the deceased liver donors in the Czech Republic.

  17. [Deceased organ donors, legal regulations governing diagnosis of brain death, overview of donors and liver transplants in the Czech Republic].

    PubMed

    Pokorná, E

    2013-08-01

    The key restriction of transplantation medicine globally, as well as in the Czech Republic, concerns the lack of organs. The number of deceased donors, and thus the availability of organ transplants, has been stagnating in our country. The paper describes current legal regulations governing the dia-gnosis of brain death and primary legal and medical criteria for the contraindication of the deceased for organ explantation, gives an overview of the number of liver transplants, age structure, and diagnosis resulting in brain death of the deceased liver donors in the Czech Republic. PMID:24007222

  18. Codes and regulations governing handling, storage, use and release of toxic gases

    NASA Astrophysics Data System (ADS)

    Bolmen, Richard A.

    1988-07-01

    To control the hazards associated with the handling, storage, use and release of toxic gases in the manufacturing process, a number of codes and regulations have been promulgated. At the forefront of these regulations are the Uniform Fire Code (UFC), Article 51, ``Semiconductor Fabrication Facilities Using Hazardous Production Materials,'' 1985 Edition; UFC Article 80, ``Hazardous Materials,'' 1987 Revision; and the Toxic Gas Model Ordinance, California Assembly Bill 1021. Article 51 of the UFC is specific for semiconductor wafer fabrication facilities and regulates the storage, handling and use of hazardous production materials. Article 80 of the UFC has a much broader scope and incorporates requirements for prevention, control and mitigation of dangerous conditions related to hazardous materials. As it applies to toxic gases, Article 80 incorporates Article 51 requirements and in addition requires treatment systems to reduce discharge concentrations and mitigate unauthorized releases of toxic gases. The Toxic Gas Model Ordinance is specific to toxic gases and regulates storage, handling and use of toxic gases at new and existing facilities incorporating monitoring and treatment systems should an unauthorized release occur. This paper will focus on these regulations as they apply to toxic gases used by the semiconductor and photovoltaics industries.

  19. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... or common law with the force and effect of law which enables the Tribe or Tribal organization to... 45 Public Welfare 2 2010-10-01 2010-10-01 false What governing Tribal law or regulations must a... ENFORCEMENT (IV-D) PROGRAM Tribal IV-D Plan Requirements § 309.90 What governing Tribal law or...

  20. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... or common law with the force and effect of law which enables the Tribe or Tribal organization to... 45 Public Welfare 2 2013-10-01 2012-10-01 true What governing Tribal law or regulations must a... ENFORCEMENT (IV-D) PROGRAM Tribal IV-D Plan Requirements § 309.90 What governing Tribal law or...

  1. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... or common law with the force and effect of law which enables the Tribe or Tribal organization to... 45 Public Welfare 2 2014-10-01 2012-10-01 true What governing Tribal law or regulations must a... ENFORCEMENT (IV-D) PROGRAM Tribal IV-D Plan Requirements § 309.90 What governing Tribal law or...

  2. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... or common law with the force and effect of law which enables the Tribe or Tribal organization to... 45 Public Welfare 2 2012-10-01 2012-10-01 false What governing Tribal law or regulations must a... ENFORCEMENT (IV-D) PROGRAM Tribal IV-D Plan Requirements § 309.90 What governing Tribal law or...

  3. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... or common law with the force and effect of law which enables the Tribe or Tribal organization to... 45 Public Welfare 2 2011-10-01 2011-10-01 false What governing Tribal law or regulations must a... ENFORCEMENT (IV-D) PROGRAM Tribal IV-D Plan Requirements § 309.90 What governing Tribal law or...

  4. 78 FR 44237 - Improving Government Regulations; Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... procurement-related, contact Mr. Manuel Quinones, telephone 571-372-6085 or write to Defense Acquisition Regulations Directorate, 4800 Mark Center Drive, Suite 15D07-2, Alexandria, VA 22350, or email: manuel.... Chip Smith, telephone 703-693-3644, or write to Office of the Deputy Assistant Secretary of the...

  5. 76 FR 64885 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... under DFARS Case 2009-D043 at 75 FR 80426 on December 22, 2010. The due date for public comments under DFARS Case 2009-D043 was extended from February 22, 2011, to April 8, 2011, by 76 FR 9527 on February 18... regulatory alternatives and, if regulation is necessary, to select regulatory approaches that maximize...

  6. 76 FR 17762 - Regulations Governing the Performance of Actuarial Services Under the Employee Retirement Income...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-31

    ... comprehensive amendments to the regulations regarding section 3042 in 1988 (53 FR 34484). In anticipation of... published in the Federal Register on June 30, 2004 (69 FR 39376). On December 21, 2007, the Joint Board... actuary in the Federal Register (72 FR 72606). On September 21, 2009, the Joint Board issued...

  7. 76 FR 61597 - Grants and Cooperative Agreements to State and Local Governments: DOT Amendments on Regulations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ... and Agreements With Institutions of Higher Education, Hospitals and Other Non-Profit Organizations..., Hospitals and Other Non-Profit Organizations. The rule amends Department of Transportation regulations on..., Hospitals and other Non-profit Organizations. Specifically, the DOT is making requirements for these...

  8. 75 FR 51713 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ..., 2007 (72 FR 54540), to modify various provisions relating to the general standards of practice. For... issued a notice of proposed rulemaking (REG-138637-07) in the Federal Register (72 FR 54621) proposing to... IRS and the Treasury Department published final regulations (TD 9436) in the Federal Register (73...

  9. TORC1 Signaling Is Governed by Two Negative Regulators in Fission Yeast

    PubMed Central

    Ma, Ning; Liu, Qingbin; Zhang, Lili; Henske, Elizabeth P.; Ma, Yan

    2013-01-01

    The target of rapamycin (TOR) is a highly conserved protein kinase that regulates cell growth and metabolism. Here we performed a genome-wide screen to identify negative regulators of TOR complex 1 (TORC1) in Schizosaccharomyces pombe by isolating mutants that phenocopy Δtsc2, in which TORC1 signaling is known to be up-regulated. We discovered that Δnpr2 displayed similar phenotypes to Δtsc2 in terms of amino acid uptake defects and mislocalization of the Cat1 permease. However, Δnpr2 and Δtsc2 clearly showed different phenotypes in terms of rapamycin supersensitivity and Isp5 transcription upon various treatments. Furthermore, we showed that Tor2 controls amino acid homeostasis at the transcriptional and post-transcriptional levels. Our data reveal that both Npr2 and Tsc2 negatively regulate TORC1 signaling, and Npr2, but not Tsc2, may be involved in the feedback loop of a nutrient-sensing pathway. PMID:23934889

  10. 77 FR 22267 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    .... SUMMARY: We propose to revise the regulations for permits for nonpurposeful take of golden eagles (Aquila chrysaetos) and bald eagles (Haliaeetus leucocephalus) where the take is associated with, but not the purpose... costs associated with working with the applicants to develop site plans and conservation measures,...

  11. 76 FR 5292 - Alternatives to Use of Credit Ratings in Regulations Governing the Federal National Mortgage...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... other purposes. 111-211......... To protect Indian arts and crafts through the improvement July 29, 2010... in 2008. 111-286......... The Physician Payment and Therapy Relief Act of 2010....... Nov. 30, 2010... references to credit ratings in their capital regulations and prudential standards. See 75 FR 49423 (Aug....

  12. 78 FR 52851 - Revisions to Procedural Regulations Governing Transportation by Intrastate Pipelines; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... was published in the Federal Register on Tuesday, July 30, ] 2013 (78 FR 45850). The regulations... ``total Annual Burden Hours'' column is changed from ``854'' to ``852''. Accordingly, in rule FR Doc. No. 2013-17822 published in the July 30, 2013 (78 FR 45850), on page 45861, in the table in paragraph...

  13. 75 FR 75444 - Defense Federal Acquisition Regulation Supplement; Government Property (DFARS Case 2009-D008)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-03

    ..., including any personal information provided. Please check http://www.regulations.gov approximately two to... submitted by mail. FOR FURTHER INFORMATION CONTACT: Ms. Mary Overstreet, 703-602-0311. SUPPLEMENTARY INFORMATION: I. Background This rule proposes to update and reorganize DFARS subparts 245.6 and 245.7...

  14. 77 FR 57055 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... tax shelter offerings in accordance with American Bar Association Formal Opinion 346 (49 FR 6719). The.... See 66 FR 3276. The 2001 notice of proposed rulemaking addressed both general matters pertaining to..., Treasury and the IRS published in the Federal Register (68 FR 75186) (the 2003 proposed regulations)...

  15. 76 FR 29665 - Migratory Bird Permits; Changes in the Regulations Governing Raptor Propagation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... propagation of raptors in the United States (70 FR 60052). We proposed to reorganize the current regulations... Propagation'' (71 FR 35599). We solicited comments on the draft environmental assessment until September 19... until November 21, 2006 (71 FR 54794). After consideration of all the comments received, we published...

  16. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... facilities; (3) Related utilization facility operations; (4) Actual and allocated well field production and injection; and (5) Related well field operations. (b) The utilization regulations in subparts 3270 through... wells intended for production or injection, which is covered in subpart 3260....

  17. Older smokers could be the strongest supporters for U.S. government regulation of tobacco: a focus group study

    PubMed Central

    2013-01-01

    Background Targeting of marginalized groups with aggressive tobacco marketing has been identified as exacerbating health disparities. However, interpretation of such targeting by groups varies, from surprise and outrage to regarding such marketing as evidence of social legitimacy. We sought to learn how an often-overlooked marginalized group, older adults, would respond to industry documents offering evidence of tobacco company target marketing. Methods We conducted 10 focus groups in California cities with older (≥50 years) smokers and former smokers. A set of previously-undisclosed tobacco industry documents related to target marketing was shown to the group in sequence. Audiotaped discussions were transcribed and data analyzed using qualitative approaches. Results Responses to evidence of tobacco industry targeting varied, with some regarding it as exploitive and others as normal business practice. However, in most groups, discussions turned to government’s failure to protect the public—even though government action /inaction was not prompted nor addressed in the discussion documents. Conclusion Given the Food and Drug Administration’s new authority to regulate tobacco products, these findings suggest that some of the tobacco industry’s “best customers” (older, established smokers and ex-smokers) may be strong supporters of government regulation of tobacco. PMID:23958397

  18. Decree No. 9 promulgating Regulations Governing Labor Protection for Women Staff Members and Workers, 21 July 1988.

    PubMed

    1988-01-01

    This document contains major provisions of a Chinese degree, issued July 21, 1988, which promulgates regulations governing the protection of all women staff members and workers in China. The regulations include a statement that the employment of women must be possible if the employer can be served by women. The employment status and wages of women are protected during pregnancy, delivery, and breast feeding. Women may not engage in underground mining or other designated labor intensive work. During menstruation and pregnancy, women must not perform tasks which are deemed to place their health at jeopardy. Maternity leave will extend for 90 days, with a possible addition in certain circumstances. Mothers at work will be allowed to breast feed infants less than a year old. The working hours of breast-feeding mothers shall not be extended, and they should not be assigned to night shifts. Employers with a large number of female employees are to take specified measures to meet their health and child care needs. Employed women with grievances can undergo an appeals process. People responsible for infringing the rights of women will be subject to administrative punishment. These regulations do not apply to individuals who violate state regulations on family planning.

  19. Off-licence prescribing and regulation in psychiatry: current challenges require a new model of governance

    PubMed Central

    Sugarman, Philip; Mitchell, Amy; Frogley, Catherine; Dickens, Geoffrey L

    2013-01-01

    The growing worldwide use of pharmaceuticals is managed in some countries by a regulatory system which sharply divides legal use into licensed and unlicensed categories. We examine how for the range of psychotropics this simultaneously restricts the possible benefits to patients, prescribers and producers in some domains, while failing to manage the risks in others. A more flexible system, which shares at an earlier stage experience and evidence on benefits and risks in patients, previously marginalized on the grounds of age, diagnosis or comorbidity, would aid the development of safer, more effective ‘real-world prescribing’. Practical recommendations are made for a new model of research and prescribing governance, to enable more effective repurposing of these treatments. PMID:24167695

  20. Complex feedback regulations govern the expression of miRNA396 and its GRF target genes.

    PubMed

    Hewezi, Tarek; Baum, Thomas J

    2012-07-01

    The beet cyst nematode, Heterodera schachtii, is a sedentary root parasite that induces the formation of a specialized root feeding structure, the syncytium. We previously have shown that coordinated regulation of miR396 and its target genes GRF1 and GRF3 in the syncytium is required for proper formation. To gain a better understanding of this coordinated regulation, we used quantitative real-time PCR to assess the abundance of primary (pri)-miRNA396a, pri-miRNA396b and mature miRNA396 in transgenic Arabidopsis plants overexpressing either wild-type variants of the GRF1 or GRF3 coding sequences or miR396-resistant variants. We also included a grf1/grf2/grf3 triple mutant in these analyses. We observed significant decreases in the abundance of pri-miRNA396a, pri-miRNA396b and mature miR396 in the transgenic plants overexpressing GRF1 or GRF3, particularly with the miRNA396-resistant variants. In contrast, the primary transcripts and mature miRNA396 abundance were significantly increased in the grf1/grf2/grf3 triple knockout mutant. These results demonstrate that homeostasis between miR396 and the target genes GRF1 and GRF3 is established through reciprocal feedback regulation, in which GRF1/GRF3 and miR396 negatively regulate each other's expression. In addition, we found that constitutive expression of GRF1 or GRF3 decreases the mRNA abundance of other GRFs, even those that are not targeted by miR396, as well as their own endogenous transcripts, which documents further regulatory facets of this equilibrium. PMID:22751317

  1. Epigenetic regulators governing cancer stem cells and epithelial-mesenchymal transition in oral squamous cell carcinoma.

    PubMed

    Patel, Shanaya; Shah, Kanisha; Mirza, Sheefa; Daga, Aditi; Rawal, Rakesh

    2015-01-01

    Oral squamous cell carcinoma (OSCC) is amongst the most prevalent form of cancer worldwide with its predominance in the Indian subcontinent due to its etiological behavioral pattern of tobacco consumption. Late diagnosis, low therapeutic response and aggressive metastasis are the foremost confounders accountable for the poor 5 year survival rate of OSCC. These failures are attributed to the existence of "Cancer Stem cell (CSC)" subpopulation within the tumour environment. Quiescence, apoptotic evasion, resistance to DNA damage, abnormal expression of drug transporter pumps and in vivo tumorigenesis are the defining hallmarks of CSC phenotype. These CSCs have been distinguished from the tumor mass by determining the expression patterns of cell surface proteins, specific stemness markers and quantifying the cellular activities such as drug efflux & aldehyde dehydrogenase activity. Hence, it is necessary to understand the underlying mechanisms that regulate the CSC features in tumor development, metastasis and response to chemotherapy. Increasing evidence suggests that majority of malignant cells eventually undergoing Epithelial-Mesenchymal transition (EMT) share many biological characteristics with CSCs. Thus, this review encompasses the functional relevance of CSC and EMT markers in OSCC population with a hope to elucidate the fundamental mechanisms underlying cancer progression and to highlight the most relevant epigenetic mechanisms that contribute to the regulation of CSC features. We further aimed to explore the causal effects of nicotine, a major tobacco carcinogen, on epigenetic mechanisms regulating the OSCC CSCs and EMT markers which unravels the undisputable contribution of tobacco in oral carcinogenesis. PMID:25330402

  2. Identification of Nuclear Protein Targets for Six Leukemogenic Tyrosine Kinases Governed by Post-Translational Regulation

    PubMed Central

    Pierce, Andrew; Williamson, Andrew; Jaworska, Ewa; Griffiths, John R.; Taylor, Sam; Walker, Michael; O’Dea, Mark Aspinall; Spooncer, Elaine; Unwin, Richard D.; Poolman, Toryn; Ray, David; Whetton, Anthony D.

    2012-01-01

    Mutated tyrosine kinases are associated with a number of different haematological malignancies including myeloproliferative disorders, lymphoma and acute myeloid leukaemia. The potential commonalities in the action of six of these leukemogenic proteins on nuclear proteins were investigated using systematic proteomic analysis. The effects on over 3600 nuclear proteins and 1500 phosphopeptide sites were relatively quantified in seven isogenic cell lines. The effects of the kinases were diverse although some commonalities were found. Comparison of the nuclear proteomic data with transcriptome data and cytoplasmic proteomic data indicated that the major changes are due to post-translational mechanisms rather than changes in mRNA or protein distribution. Analysis of the promoter regions of genes whose protein levels changed in response to the kinases showed the most common binding site found was that for NFκB whilst other sites such as those for the glucocorticoid receptor were also found. Glucocorticoid receptor levels and phosphorylation were decreased by all 6 PTKs. Whilst Glucocorticoid receptor action can potentiate NFκB action those proteins where genes have NFκB binding sites were in often regulated post-translationally. However all 6 PTKs showed evidence of NFkB pathway modulation via activation via altered IkB and NFKB levels. Validation of a common change was also undertaken with PMS2, a DNA mismatch repair protein. PMS2 nuclear levels were decreased in response to the expression of all 6 kinases, with no concomitant change in mRNA level or cytosolic protein level. Response to thioguanine, that requires the mismatch repair pathway, was modulated by all 6 oncogenic kinases. In summary common targets for 6 oncogenic PTKs have been found that are regulated by post-translational mechanisms. They represent potential new avenues for therapies but also demonstrate the post-translational regulation is a key target of leukaemogenic kinases. PMID:22745689

  3. Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications

    PubMed Central

    Ulrich-Lai, Yvonne M.; Ryan, Karen K.

    2014-01-01

    Significant co-morbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions between energy balance and brain stress integration. Largely overlapping neural circuits control these systems, and this anatomical arrangement optimizes opportunities for mutual influence. Here we first review the current literature identifying effects of metabolic neuroendocrine signals on stress regulation, and vice versa. Next, the contributions of reward driven food intake to these metabolic and stress interactions are discussed. Lastly, we consider the inter-relationships among metabolism, stress and reward in light of their important implications in the development of therapies for metabolism- or stress-related disease. PMID:24630812

  4. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.

    PubMed

    Berchowitz, Luke E; Kabachinski, Greg; Walker, Margaret R; Carlile, Thomas M; Gilbert, Wendy V; Schwartz, Thomas U; Amon, Angelika

    2015-10-01

    Message-specific translational control is required for gametogenesis. In yeast, the RNA-binding protein Rim4 mediates translational repression of numerous mRNAs, including the B-type cyclin CLB3, which is essential for establishing the meiotic chromosome segregation pattern. Here, we show that Rim4 forms amyloid-like aggregates and that it is the amyloid-like form of Rim4 that is the active, translationally repressive form of the protein. Our data further show that Rim4 aggregation is a developmentally regulated process. Starvation induces the conversion of monomeric Rim4 into amyloid-like aggregates, thereby activating the protein to bring about repression of translation. At the onset of meiosis II, Rim4 aggregates are abruptly degraded allowing translation to commence. Although amyloids are best known for their role in the etiology of diseases such as Alzheimer's, Parkinson's, and diabetes by forming toxic protein aggregates, our findings show that cells can utilize amyloid-like protein aggregates to function as central regulators of gametogenesis. PMID:26411291

  5. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

    PubMed Central

    Shimokawa, Noriaki; Haglund, Kaisa; Hölter, Sabine M; Grabbe, Caroline; Kirkin, Vladimir; Koibuchi, Noriyuki; Schultz, Christian; Rozman, Jan; Hoeller, Daniela; Qiu, Chun-Hong; Londoño, Marina B; Ikezawa, Jun; Jedlicka, Peter; Stein, Birgit; Schwarzacher, Stephan W; Wolfer, David P; Ehrhardt, Nicole; Heuchel, Rainer; Nezis, Ioannis; Brech, Andreas; Schmidt, Mirko H H; Fuchs, Helmut; Gailus-Durner, Valerie; Klingenspor, Martin; Bogler, Oliver; Wurst, Wolfgang; Deller, Thomas; de Angelis, Martin Hrabé; Dikic, Ivan

    2010-01-01

    Despite extensive investigations of Cbl-interacting protein of 85 kDa (CIN85) in receptor trafficking and cytoskeletal dynamics, little is known about its functions in vivo. Here, we report the study of a mouse deficient of the two CIN85 isoforms expressed in the central nervous system, exposing a function of CIN85 in dopamine receptor endocytosis. Mice lacking CIN85 exon 2 (CIN85Δex2) show hyperactivity phenotypes, characterized by increased physical activity and exploratory behaviour. Interestingly, CIN85Δex2 animals display abnormally high levels of dopamine and D2 dopamine receptors (D2DRs) in the striatum, an important centre for the coordination of animal behaviour. Importantly, CIN85 localizes to the post-synaptic compartment of striatal neurons in which it co-clusters with D2DRs. Moreover, it interacts with endocytic regulators such as dynamin and endophilins in the striatum. Absence of striatal CIN85 causes insufficient complex formation of endophilins with D2DRs in the striatum and ultimately decreased D2DR endocytosis in striatal neurons in response to dopamine stimulation. These findings indicate an important function of CIN85 in the regulation of dopamine receptor functions and provide a molecular explanation for the hyperactive behaviour of CIN85Δex2 mice. PMID:20551902

  6. Protein kinase G–regulated production of H2S governs oxygen sensing

    PubMed Central

    Yuan, Guoxiang; Vasavda, Chirag; Peng, Ying-Jie; Makarenko, Vladislav V.; Raghuraman, Gayatri; Nanduri, Jayasri; Gadalla, Moataz M.; Semenza, Gregg L.; Kumar, Ganesh K.; Snyder, Solomon H.; Prabhakar, Nanduri R.

    2015-01-01

    Reflexes initiated by the carotid body, the principal O2-sensing organ, are critical for maintaining cardio-respiratory homeostasis during hypoxia. O2 sensing by the carotid body requires carbon monoxide (CO) generation by heme oxygenase-2 (HO-2) and hydrogen sulfide (H2S) synthesis by cystathionine-γ-lyase (CSE). We report that O2 stimulated the generation of CO, but not that of H2S, and required two cysteine residues in the heme regulatory motif (Cys265 and Cys282) of HO-2. CO stimulated protein kinase G (PKG)–dependent phosphorylation of Ser377 of CSE, inhibiting the production of H2S. Hypoxia decreased the inhibition of CSE by reducing CO generation resulting in increased H2S, which stimulated carotid body neural activity. In carotid bodies from mice lacking HO-2, compensatory increased abundance of nNOS (neuronal nitric oxide synthase) mediated O2 sensing through PKG-dependent regulation of H2S by nitric oxide. These results provide a mechanism for how three gases work in concert in the carotid body to regulate breathing. PMID:25900831

  7. An analysis of potential barriers and enablers to regulating the television marketing of unhealthy foods to children at the state government level in Australia

    PubMed Central

    2012-01-01

    Background In Australia there have been many calls for government action to halt the effects of unhealthy food marketing on children's health, yet implementation has not occurred. The attitudes of those involved in the policy-making process towards regulatory intervention governing unhealthy food marketing are not well understood. The objective of this research was to understand the perceptions of senior representatives from Australian state and territory governments, statutory authorities and non-government organisations regarding the feasibility of state-level government regulation of television marketing of unhealthy food to children in Australia. Method Data from in-depth semi-structured interviews with senior representatives from state and territory government departments, statutory authorities and non-government organisations (n=22) were analysed to determine participants' views about regulation of television marketing of unhealthy food to children at the state government level. Data were analysed using content and thematic analyses. Results Regulation of television marketing of unhealthy food to children was supported as a strategy for obesity prevention. Barriers to implementing regulation at the state level were: the perception that regulation of television advertising is a Commonwealth, not state/territory, responsibility; the power of the food industry and; the need for clear evidence that demonstrates the effectiveness of regulation. Evidence of community support for regulation was also cited as an important factor in determining feasibility. Conclusions The regulation of unhealthy food marketing to children is perceived to be a feasible strategy for obesity prevention however barriers to implementation at the state level exist. Those involved in state-level policy making generally indicated a preference for Commonwealth-led regulation. This research suggests that implementation of regulation of the television marketing of unhealthy food to children

  8. Regulations governing veterinary medicinal products containing genetically modified organisms in the European community.

    PubMed

    Moulin, G

    2005-04-01

    This paper describes particular aspects of the marketing of veterinary medicinal products (VMPs) that contain or consist of genetically modified micro-organisms (GMMs) or genetically modified organisms (GMOs). The regulatory requirements and the procedures applied in the European Union for each phase (pre-marketing, authorisation process, and post-authorisation labelling and monitoring) are explained. In most cases VMPs are subject to both pharmaceutical and GMO regulations. In the early stages of the process, before applications for marketing authorisation are submitted, the assessment of clinical trials and experiments in contained areas is principally the responsibility of national authorities. However, the marketing of all VMPs containing or consisting of GMOs must be authorised at European level, although the national authorities are informed and involved in the assessment process.

  9. Quality, quantity and distribution of medical education and care: regulation by the private sector or mandate by government?

    PubMed

    Anlyan, W G

    1975-05-01

    The public, the federal government and most state governments have become increasingly concerned with the lack of access to primary care as well as the specialty and geographic maldistribution problems. Currently, there is a race in progress between the private sector and the federal government to devise solutions to these problems. In the federal sector, varying pieces of legislation are under active consideration to mandate the correction of specialty and geographic maldistribution; proposals include: 1) setting up federal machinery to regulate the numbers and types of residencies; 2) make obligatory the creation of Departments of Family Practice in each medical school; 3) withdraw current education support from medical schools causing tuition levels to increase substantially--federal student loans would then provide the necessary leverage to obligate the borrower to two years of service in an under-served area in exchange for loan forgiveness. In the private sector, for the first time in the history of the United States, the five major organizations involved in medical care have organized to form the Coordinating Council on Medical Education (CCME) and the Liaison Committee on Graduate Medical Education (LCGME). One of the initial major endeavors of the CCME has been to address itself to the problem of specialty maldistribution. The LCGME has been tooling up to become the accrediting group for residency training thus providing an overview of the quality and quantity of specialty training. It will be the intent of this presentation to bring the membership of the Southern Surgical Association an up-to-date report on these parallel efforts. The author's personal hope is that the private sector can move sufficiently rapidly to set up its own regulatory mechanisms and avert another federally controlled bureaucracy that will forever change the character of the medical profession in the United States.

  10. Incentives and regulations to reconcile conservation and development: thirty years of governance of the Sami pastoral ecosystem in Finnmark, Norway.

    PubMed

    Ulvevadet, Birgitte; Hausner, Vera H

    2011-10-01

    Incentive-based mechanisms are regarded as efficient instruments to reconcile conservation and development. This win-win objective has been difficult to accomplish; cross-compliance has, therefore, been suggested as a mechanism to ensure sustainability. Cross-compliance, which requires producers to conform to production regulations and environmental standards to qualify for direct payments, has been a popular instrument in the Common Agricultural Policy (CAP) reform. Since 1990, cross-compliance has been the main characteristic of policy design in Sami reindeer husbandry in Finnmark, Norway. All direct transfers to the Sami pastoralists have been connected to harvesting demands to decrease the number of reindeer and to conserve pastures. The content of these incentive-based mechanisms are decided through negotiated agreements with the Sami Reindeer Herders' Association of Norway (NRL), and the regulation of reindeer numbers and access to pastures are delegated to co-management boards. Despite the participation of the Sami pastoralists in shaping these policies, win-win objectives have not been achieved. Although the cross-compliance program could have been improved by payment for graded results, the lack of regulations by the administration or co-management boards is more likely to be the cause of failure to reach sustainability. Despite the long-term failures of the cross-compliance program, policies have been slow to change. We might attribute this delay to the NRL's strong position in the negotiated agreements. In general, we argue that the success of the cross-compliance program depends on a well-functioning governance system that can implement regulations and sanctions if incentives do not work as intended.

  11. Government Regulatory

    NASA Astrophysics Data System (ADS)

    Becker, Katie

    Government regulation of food products, food processing, and food preparation is imperative in bringing an unadulterated, nonmisleading, and safe food product to market and is relevant to all areas of food science, including engineering, processing, chemistry, and microbiology. The liability associated with providing consumers with an adulterated or substandard product cannot only tarnish a company's name and reputation, but also impose substantial financial repercussions on the company and those individuals who play an active role in the violation. In order for a company to fully comply with the relevant food laws (both federal and state), an intimate knowledge of food science is required. Individuals knowledgeable in food science play an integral role not only in implementing and counseling food companies/processors to ensure compliance with government regulations, but these individuals are also necessary to the state and federal governments that make and enforce the relevant laws and regulators.

  12. M.I.T. and the Federal Government. An Examination of the Effects of Government Regulation and Research Support on Selected Parts of M.I.T.

    ERIC Educational Resources Information Center

    Garvin, David

    A self-study was undertaken at the Massachusetts Institute of Technology (M.I.T.) to examine the impact of the federal government on it. M.I.T. is a large institution with an enrollment of 8,000, a faculty of 950, and a total teaching staff of 1,700. Of its operating expenses by far the largest source of funds in recent years has been sponsored…

  13. Government regulation of pricing and reimbursement of prescription medicines: results of a recent multi-country review.

    PubMed

    Kingham, Richard; Wheeler, Joanna

    2009-01-01

    Access to prescription medicines is an essential component of publicly funded or publicly assisted healthcare programs. Thus, important policy questions are presented when government agencies that administer those programs establish procedures for making decisions about the appropriate use of medicines, including determinations as to which medicines will be reimbursed, at what prices, and for which patients. The authors reviewed systems for making determinations on pricing and reimbursement of prescription medicines under public healthcare systems in 10 countries, including four member states of the European Union (EU) (France, Germany, Italy and the United Kingdom), plus Australia, Brazil, China, India, Japan and Korea. In addition to national regulatory requirements, the authors considered international agreements that may impose obligations with respect to procedures for pricing and reimbursement of prescription medicines, including the EU's Transparency Directive, agreements administered by the World Trade Organization (WTO), and bilateral free trade agreements negotiated by the United States in recent years. Drawing on this experience, the authors sought to identify common themes, pitfalls and best practices in national systems for regulating pricing and reimbursement of prescription medicines. The authors have focused primarily on procedures, rather than the underlying political assumptions or substantive economic objectives. They have assumed that all countries have--or should have--a common interest in assuring that decision-making procedures afford interested persons who have relevant information a meaningful opportunity to participate

  14. Foundations for the Future of Alberta's Metis Settlements. Report of the MacEwan Joint Metis-Government Committee to Review the Metis Betterment Act and Regulations.

    ERIC Educational Resources Information Center

    Alberta Ministry of Municipal Affairs, Edmonton.

    Prepared as a working document for officials of the Alberta (Canada) government, this report reviews the Metis Betterment Act and regulations made under the Act with one goal being to ensure that any proposals for a new Act would place the major responsibility for the political, social, economic, and cultural development of the settlements firmly…

  15. Renewing governance.

    PubMed

    Loos, Gregory P

    2003-01-01

    Globalization's profound influence on social and political institutions need not be negative. Critics of globalization have often referred to the "Impossible Trinity" because decision-making must 1. respect national sovereignty, 2. develop and implement firm regulation, and 3. allow capital markets to be as free as possible. To many, such goals are mutually exclusive because history conditions us to view policy-making and governance in traditional molds. Thus, transnational governance merely appears impossible because current forms of governance were not designed to provide it. The world needs new tools for governing, and its citizens must seize the opportunity to help develop them. The rise of a global society requires a greater level of generality and inclusion than is found in most policy bodies today. Politicians need to re-examine key assumptions about government. States must develop ways to discharge their regulatory responsibilities across borders and collaborate with neighboring jurisdictions, multilateral bodies, and business. Concepts such as multilateralism and tripartism show great promise. Governments must engage civil society in the spirit of shared responsibility and democratic decision-making. Such changes will result in a renewal of the state's purpose and better use of international resources and expertise in governance. PMID:17208717

  16. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Asian Longhorned Beetle § 301.51-4 Conditions governing the interstate movement... beetle; and (C) The article has not been combined or commingled with other articles so as to lose...

  17. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Asian Longhorned Beetle § 301.51-4 Conditions governing the interstate movement... beetle; and (C) The article has not been combined or commingled with other articles so as to lose...

  18. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Asian Longhorned Beetle § 301.51-4 Conditions governing the interstate movement... beetle; and (C) The article has not been combined or commingled with other articles so as to lose...

  19. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Asian Longhorned Beetle § 301.51-4 Conditions governing the interstate movement... beetle; and (C) The article has not been combined or commingled with other articles so as to lose...

  20. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  1. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  2. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  3. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other...

  4. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... experimental or scientific purposes; or (ii) The regulated article originates outside the quarantined area and... traffic conditions such as traffic lights and stop signs); and (C) The regulated article is not...

  5. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... regulated article is moved through the quarantined area without stopping (except for refueling and for traffic conditions such as traffic lights and stop signs); and (C) The regulated article is not unpacked... authorized to stop the person or means of conveyance to determine whether a regulated article is present...

  6. Self-Study Report by Roosevelt University on the Impact of Government Programs and the Cost of Compliance With Government Regulations for the Sloan Commission on Government and Higher Education.

    ERIC Educational Resources Information Center

    Perlman, Daniel H.

    A study was conducted to assess the impact of federal and state assistance, regulations, and requirements on Roosevelt University, Chicago. By means of a survey questionnaire and interviews, the University's vice presidents and other senior administrators were asked to estimate the amount of time and money spent by the school to comply with…

  7. United States Government Accountability Office report on nanotechnology: nanomaterials are widely used in commerce, but EPA faces challenges in regulating risk.

    PubMed

    2010-01-01

    Nanotechnology involves the ability to control matter at the scale of a nanometer--one billionth of a meter. The world market for products that contain nanomaterials is expected to reach $2.6 trillion by 2015. In this context, the United States Government Accountability Office (GAO): (1) identified examples of current and potential uses of nanomaterials, (2) determined what is known about the potential human health and environmental risks from nanomaterials, (3) assessed actions the Environmental Protection Agency (EPA) has taken to better understand and regulate the risks posed by nanomaterials as well as its authorities to do so, and (4) identified approaches that other selected national authorities and U.S. states have taken to address the potential risks associated with nanomaterials. The GAO analyzed selected laws and regulations, reviewed information on the EPA's Nanoscale Materials Stewardship Program, and consulted with EPA officials and legal experts to obtain their perspectives on the EPA's authorities to regulate nanomaterials.

  8. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Fruit Flies § 301.32-4 Conditions governing the interstate movement of... enclosed vehicle or is completely enclosed by a covering adequate to prevent access by fruit flies (such as... prevent the spread of fruit flies; and (4) With a tag or label bearing the number of the permit issued...

  9. 75 FR 78900 - Regulations Governing Book-Entry Treasury Bonds, Notes and Bills Held in Legacy Treasury Direct...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... States securities, which are contracts between Treasury and the owner of the security, this rule falls... linked accounts have had no holdings and no activity for a period of two years, we reserve the right to... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE...

  10. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  11. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  12. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  13. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  14. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  15. 49 CFR 350.341 - What specific variances from the FMCSRs are allowed for State laws and regulations governing...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... mileage radius exemption contained in 49 CFR 395.1(e) from 100 to 150 miles. (e) Hours of service—State... intrastate commerce and not subject to Federal jurisdiction? 350.341 Section 350.341 Transportation Other... governing motor carriers, CMV drivers, and CMVs engaged in intrastate commerce and not subject to...

  16. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Fruit Flies § 301.32-4 Conditions governing the interstate movement of... enclosed vehicle or is completely enclosed by a covering adequate to prevent access by fruit flies (such as... prevent the spread of fruit flies; and (4) With a tag or label bearing the number of the permit issued...

  17. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Fruit Flies § 301.32-4 Conditions governing the interstate movement of... enclosed vehicle or is completely enclosed by a covering adequate to prevent access by fruit flies (such as... prevent the spread of fruit flies; and (4) With a tag or label bearing the number of the permit issued...

  18. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Fruit Flies § 301.32-4 Conditions governing the interstate movement of... enclosed vehicle or is completely enclosed by a covering adequate to prevent access by fruit flies (such as... prevent the spread of fruit flies; and (4) With a tag or label bearing the number of the permit issued...

  19. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., Department of Agriculture rules and rules of the Department of Interior at 50 CFR parts 10 through 24 and... sources of drinking water. 4. If the project may impact a historic property, it is subject to the National... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications...

  20. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 745 and rules on animal acquisition, transport, care, handling and use in 9 CFR parts 1 through 4... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and.... Prohibitions on discrimination on the basis of race, color, or national origin in Title VI of the Civil...

  1. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 745 and rules on animal acquisition, transport, care, handling and use in 9 CFR parts 1 through 4... Government-wide common rule that the DOE has codified at 10 CFR part 601. The “List of Certifications and.... Prohibitions on discrimination on the basis of race, color, or national origin in Title VI of the Civil...

  2. Designing the Framework Conditions for Assuring Academic Standards: Lessons Learned about Professional, Market, and Government Regulation of Academic Quality

    ERIC Educational Resources Information Center

    Dill, David D.; Beerkens, Maarja

    2013-01-01

    The new demands of mass systems of higher education and the emerging environment of global academic competition are altering the traditional institutions for assuring academic standards in universities. As a consequence many nations are experimenting with new instruments for academic quality assurance. Contemporary government control of academic…

  3. Tough but True: School Board Neglect of Bus Safety Led to Government's Overblown, Under-Researched Regulations.

    ERIC Educational Resources Information Center

    American School Board Journal, 1978

    1978-01-01

    The apparent lack of concern school boards evidenced in the past over school bus safety has precipitated the National Highway Traffic Safety Administration regulations that have angered board members and bus manufacturers alike. It is argued that the new regulations are not based on research. (Author/IRT)

  4. 7 CFR 301.50-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... certificate or limited permit, if: (1)(i) The regulated article originates outside any quarantined area and is... conditions, such as traffic lights or stop signs) during October, November, or December, or when ambient air temperature is below 10 °C (50 °F); or (ii) The regulated article originates outside any quarantined area...

  5. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Regulation Section and Age Distinction CFDA Veterans' Benefits Adjudication (38 CFR part 3) Section 3.57... death. . . .” Survivors' and Dependents' Educational Assistance Adjudication (38 CFR part 3) Section...

  6. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Regulation Section and Age Distinction CFDA Veterans' Benefits Adjudication (38 CFR part 3) Section 3.57... death. . . .” Survivors' and Dependents' Educational Assistance Adjudication (38 CFR part 3) Section...

  7. Regulation to Create Environments Conducive to Physical Activity: Understanding the Barriers and Facilitators at the Australian State Government Level

    PubMed Central

    Shill, Jane; Mavoa, Helen; Crammond, Brad; Loff, Bebe; Peeters, Anna; Lawrence, Mark; Allender, Steven; Sacks, Gary; Swinburn, Boyd A.

    2012-01-01

    Introduction Policy and regulatory interventions aimed at creating environments more conducive to physical activity (PA) are an important component of strategies to improve population levels of PA. However, many potentially effective policies are not being broadly implemented. This study sought to identify potential policy/regulatory interventions targeting PA environments, and barriers/facilitators to their implementation at the Australian state/territory government level. Methods In-depth interviews were conducted with senior representatives from state/territory governments, statutory authorities and non-government organisations (n = 40) to examine participants': 1) suggestions for regulatory interventions to create environments more conducive to PA; 2) support for preselected regulatory interventions derived from a literature review. Thematic and constant comparative analyses were conducted. Results Policy interventions most commonly suggested by participants fell into two areas: 1) urban planning and provision of infrastructure to promote active travel; 2) discouraging the use of private motorised vehicles. Of the eleven preselected interventions presented to participants, interventions relating to walkability/cycling and PA facilities received greatest support. Interventions involving subsidisation (of public transport, PA-equipment) and the provision of more public transport infrastructure received least support. These were perceived as not economically viable or unlikely to increase PA levels. Dominant barriers were: the powerful ‘road lobby’, weaknesses in the planning system and the cost of potential interventions. Facilitators were: the provision of evidence, collaboration across sectors, and synergies with climate change/environment agendas. Conclusion This study points to how difficult it will be to achieve policy change when there is a powerful ‘road lobby’ and government investment prioritises road infrastructure over PA

  8. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... scientific purposes; or (2) The regulated article originates outside the quarantined area and is moved... stopping (except for refueling or for traffic conditions, such as traffic lights or stop signs), or...

  9. Have government regulations improved workplace safety? A test of the asynchronous regulatory effects in China's coal industry, 1995-2006

    SciTech Connect

    Shi, X.P.

    2009-07-01

    Empirical studies on the effectiveness of workplace safety regulations are inconclusive. This study hypothesizes that the asynchronous effects of safety regulations occur because regulations need time to become effective. Safety regulations will work initially by reducing the most serious accidents, and later by improving overall safety performance. The hypothesis is tested by studying a provincial level aggregate panel dataset for China's coal industry using two different models with different sets of dependent variables: a fixed-effects model on mortality rate, which is defined as fatalities per 1,000 employees; and a negative binominal model on the annual number (frequency) of disastrous accidents. Safety regulations can reduce the frequency of disastrous accidents, but have not reduced mortality rate, which represents overall safety performance. Policy recommendations are made, including shifting production from small to large mines through industrial consolidation, improving the safety performance of large mines, addressing consequences of decentralization, and facilitating the implementation of regulations through carrying on institutional actions and supporting legislation.

  10. Spatial Phosphoprotein Profiling Reveals a Compartmentalized Extracellular Signal-regulated Kinase Switch Governing Neurite Growth and Retraction

    SciTech Connect

    Wang, Yingchun; Yang, Feng; Fu, Yi; Huang, Xiahe; Wang, Wei; Jiang, Xining; Gritsenko, Marina A.; Zhao, Rui; Monroe, Matthew E.; Pertz, Olivier C.; Purvine, Samuel O.; Orton, Daniel J.; Jacobs, Jon M.; Camp, David G.; Smith, Richard D.; Klemke, Richard L.

    2011-05-20

    Abstract - Brain development and spinal cord regeneration require neurite sprouting and growth cone navigation in response to extension and collapsing factors present in the extracellular environment. These external guidance cues control neurite growth cone extension and retraction processes through intracellular protein phosphorylation of numerous cytoskeletal, adhesion, and polarity complex signaling proteins. However, the complex kinase/substrate signaling networks that mediate neuritogenesis have not been investigated. Here, we compare the neurite phosphoproteome under growth and retraction conditions using neurite purification methodology combined with mass spectrometry. More than 4000 non-redundant phosphorylation sites from 1883 proteins have been annotated and mapped to signaling pathways that control kinase/phosphatase networks, cytoskeleton remodeling, and axon/dendrite specification. Comprehensive informatics and functional studies revealed a compartmentalized ERK activation/deactivation cytoskeletal switch that governs neurite growth and retraction, respectively. Our findings provide the first system-wide analysis of the phosphoprotein signaling networks that enable neurite growth and retraction and reveal an important molecular switch that governs neuritogenesis.

  11. CpsR, a GntR family regulator, transcriptionally regulates capsular polysaccharide biosynthesis and governs bacterial virulence in Streptococcus pneumoniae

    PubMed Central

    Wu, Kaifeng; Xu, Hongmei; Zheng, Yuqiang; Wang, Libin; Zhang, Xuemei; Yin, Yibing

    2016-01-01

    Transcriptional regulation of capsule expression is critical for pneumococcal transition from carriage to infection, yet the underlying mechanism remains incompletely understood. Here, we describe the regulation of capsular polysaccharide, one of the most important pneumococcal virulence factor by a GntR family regulator, CpsR. Electrophoretic mobility-shift assays have shown the direct interaction between CpsR and the cps promoter (cpsp), and their interaction could be competitively interfered by glucose. DNase I footprinting assays localized the binding site to a region −146 to −114 base pairs relative to the transcriptional start site of the cps locus in S. pneumoniae D39. We found that CpsR negatively controlled the transcription of the cps locus and hence CPS production, which was confirmed by fine-tuning expression of CpsR in a ΔcpsR complemented strain. Increased expression of CpsR in complemented strain led to a decreased resistance to the whole-blood-mediated killing, suggesting a protective role for CpsR-cpsp interaction in the establishment of invasive infection. Finally, animal experiments showed that CpsR-cpsp interaction was necessary for both pneumococcal colonization and invasive infection. Taken together, our results provide a thorough insight into the regulation of capsule production mediated by CpsR and its important roles in pneumococcal pathogenesis. PMID:27386955

  12. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... samples for processing, testing, or analysis may be moved interstate from any quarantined State under the..., testing or analysis may be moved interstate from any regulated area only to laboratories approved 3 by...

  13. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES... all other applicable Federal domestic plant quarantines and regulations must also be met. (1) With a... for refueling, rest stops, emergency repairs, and for traffic conditions, such as traffic lights...

  14. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES... all other applicable Federal domestic plant quarantines and regulations must also be met. (1) With a... for refueling, rest stops, emergency repairs, and for traffic conditions, such as traffic lights...

  15. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES... all other applicable Federal domestic plant quarantines and regulations must also be met. (1) With a... for refueling, rest stops, emergency repairs, and for traffic conditions, such as traffic lights...

  16. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES... all other applicable Federal domestic plant quarantines and regulations must also be met. (1) With a... for refueling, rest stops, emergency repairs, and for traffic conditions, such as traffic lights...

  17. 7 CFR 301.92-4 - Conditions governing the interstate movement of regulated, restricted, and associated articles...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES... all other applicable Federal domestic plant quarantines and regulations must also be met. (1) With a... for refueling, rest stops, emergency repairs, and for traffic conditions, such as traffic lights...

  18. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Adjudication (38 CFR part 3) Section 3.57 defines the term “child” of a veteran as, “. . . an unmarried person... Adjudication (38 CFR part 3) Section 3.807(d) sets forth basic eligibility criteria for the program...

  19. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Adjudication (38 CFR part 3) Section 3.57 defines the term “child” of a veteran as, “. . . an unmarried person... Adjudication (38 CFR part 3) Section 3.807(d) sets forth basic eligibility criteria for the program...

  20. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Section 90.31(f) of the governmentwide regulations (45 CFR part 90) requires each Federal agency to... Adjudication (38 CFR part 3) Section 3.57 defines the term “child” of a veteran as, “. . . an unmarried person... Adjudication (38 CFR part 3) Section 3.807(d) sets forth basic eligibility criteria for the program...

  1. Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use.

    PubMed

    Centner, Terence J

    2016-09-01

    The development of bacteria resistant to antibiotics is viewed as a medical health threat. Because thousands of people die every year due to antibiotic-resistant bacteria, efforts are underway to reduce antibiotic usage which in turn will reduce the development of antibiotic-resistant bacteria. In the United States, the use of antibiotics in the production of food animals to enhance animal growth has been identified as contributing to resistance. In 2015, a veterinary feed directive was adopted by the U.S. federal government prohibiting nontherapeutic uses of antibiotics in food animals that should reduce usage. The continued usage of antibiotics by producers for preventing disease may mean the directive is insufficient to reduce nontherapeutic antibiotic administration. This may lead some consumers to seek meat products from animals raised without antibiotics. A governmentally-sponsored labeling program could encourage reduction in antibiotic usage. PMID:27182666

  2. Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use.

    PubMed

    Centner, Terence J

    2016-09-01

    The development of bacteria resistant to antibiotics is viewed as a medical health threat. Because thousands of people die every year due to antibiotic-resistant bacteria, efforts are underway to reduce antibiotic usage which in turn will reduce the development of antibiotic-resistant bacteria. In the United States, the use of antibiotics in the production of food animals to enhance animal growth has been identified as contributing to resistance. In 2015, a veterinary feed directive was adopted by the U.S. federal government prohibiting nontherapeutic uses of antibiotics in food animals that should reduce usage. The continued usage of antibiotics by producers for preventing disease may mean the directive is insufficient to reduce nontherapeutic antibiotic administration. This may lead some consumers to seek meat products from animals raised without antibiotics. A governmentally-sponsored labeling program could encourage reduction in antibiotic usage.

  3. "Governance" or "Governing"?

    ERIC Educational Resources Information Center

    Leslie, David

    This paper draws on four perspectives on power and its exercise in organizations to analyze the practice of governing colleges and universities. The exploration uses political theories (particularly those assessing the legitimacy and effectiveness of stable political entities), leadership studies, analyses of how formal and informal organizations…

  4. Regulation of T cell-dendritic cell interactions by IL-7 governs T-cell activation and homeostasis

    PubMed Central

    Saini, Manoj; Pearson, Claire

    2009-01-01

    Interleukin-7 (IL-7) plays a central role in the homeostasis of the T-cell compartment by regulating T-cell survival and proliferation. Whether IL-7 can influence T-cell receptor (TCR) signaling in T cells remains controversial. Here, using IL-7–deficient hosts and TCR-transgenic T cells that conditionally express IL-7R, we examined antigen-specific T-cell responses in vitro and in vivo to viral infection and lymphopenia to determine whether IL-7 signaling influences TCR-triggered cell division events. In vitro, we could find no evidence that IL-7 signaling could costimulate T-cell activation over a broad range of conditions, suggesting that IL-7 does not directly tune TCR signaling. In vivo, however, we found an acute requirement for IL-7 signaling for efficiently triggering T-cell responses to influenza A virus challenge. Furthermore, we found that IL-7 was required for the enhanced homeostatic TCR signaling that drives lymphopenia-induced proliferation by a mechanism involving efficient contacts of T cells with dendritic cells. Consistent with this, saturating antigen-presenting capacity in vivo overcame the triggering defect in response to cognate peptide. Thus, we demonstrate a novel role for IL-7 in regulating T cell–dendritic cell interactions that is essential for both T-cell homeostasis and activation in vivo. PMID:19357399

  5. REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation

    PubMed Central

    Garcia-Manteiga, Jose M.; Bonfiglio, Silvia; Folladori, Lucrezia; Malosio, Maria L.; Lazarevic, Dejan; Stupka, Elia; Cittaro, Davide; Meldolesi, Jacopo

    2015-01-01

    The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes, mostly based on indirect criteria, and demonstration of their operative dependence on the repressor have been established for only a relatively small fraction. In the present study, starting from our recently published work, we have expanded the identification of REST-dependent genes, investigated in two clones of the PC12 line, a recognized neuronal cell model, spontaneously expressing different levels of REST: very low as in neurons and much higher as in most non-neural cells. The molecular, structural and functional differences of the two PC12 clones were shown to depend largely on their different REST level and the ensuing variable expression of some dependent genes. Comprehensive RNA-Seq analyses of the 13,700 genes expressed, validated by parallel RT-PCR and western analyses of mRNAs and encoded proteins, identified in the high-REST clone two groups of almost 900 repressed and up-regulated genes. Repression is often due to direct binding of REST to target genes; up-regulation to indirect mechanism(s) mostly mediated by REST repression of repressive transcription factors. Most, but not all, genes governing neurosecretion, excitability, and receptor channel signaling were repressed in the high REST clone. The genes governing expression of non-channel receptors (G protein-coupled and others), although variably affected, were often up-regulated together with the genes of intracellular kinases, small G proteins, cytoskeleton, cell adhesion, and extracellular matrix proteins. Expression of REST-dependent genes governing functions other than those mentioned so far were also identified. The results obtained by the parallel investigation of the two PC12 clones revealed the complexity of the REST molecular and

  6. Adapting to extreme events related to natural variability and climate change: the imperative of coupling technology with strong regulation and governance.

    PubMed

    Kythreotis, A P; Mercer, T G; Frostick, L E

    2013-09-01

    In recent years there has been an increase in extreme events related to natural variability (such as earthquakes, tsunamis and hurricanes) and climate change (such as flooding and more extreme weather). Developing innovative technologies is crucial in making society more resilient to such events. However, little emphasis has been placed on the role of human decision-making in maximizing the positive impacts of technological developments. This is exacerbated by the lack of appropriate adaptation options and the privatization of existing infrastructure, which can leave people exposed to increasing risk. This work examines the need for more robust government regulation and legislation to complement developments and innovations in technology in order to protect communities against such extreme events.

  7. Adapting to extreme events related to natural variability and climate change: the imperative of coupling technology with strong regulation and governance.

    PubMed

    Kythreotis, A P; Mercer, T G; Frostick, L E

    2013-09-01

    In recent years there has been an increase in extreme events related to natural variability (such as earthquakes, tsunamis and hurricanes) and climate change (such as flooding and more extreme weather). Developing innovative technologies is crucial in making society more resilient to such events. However, little emphasis has been placed on the role of human decision-making in maximizing the positive impacts of technological developments. This is exacerbated by the lack of appropriate adaptation options and the privatization of existing infrastructure, which can leave people exposed to increasing risk. This work examines the need for more robust government regulation and legislation to complement developments and innovations in technology in order to protect communities against such extreme events. PMID:23889236

  8. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  9. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  10. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  11. An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

    PubMed Central

    Brundin, L; Sellgren, C M; Lim, C K; Grit, J; Pålsson, E; Landén, M; Samuelsson, M; Lundgren, K; Brundin, P; Fuchs, D; Postolache, T T; Traskman-Bendz, L; Guillemin, G J; Erhardt, S

    2016-01-01

    Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved in neuroinflammation and regulates glutamate neurotransmission. In the cerebrospinal fluid (CSF) of suicidal patients, levels of inflammatory cytokines and the kynurenine metabolite quinolinic acid (QUIN), an N-methyl-d-aspartate receptor agonist, are increased. The enzyme amino-β-carboxymuconate-semialdehyde-decarboxylase (ACMSD) limits QUIN formation by competitive production of the neuroprotective metabolite picolinic acid (PIC). Therefore, decreased ACMSD activity can lead to excess QUIN. We tested the hypothesis that deficient ACMSD activity underlies suicidal behavior. We measured PIC and QUIN in CSF and plasma samples from 137 patients exhibiting suicidal behavior and 71 healthy controls. We used DSM-IV and the Montgomery-Åsberg Depression Rating Scale and Suicide Assessment Scale to assess behavioral changes. Finally, we genotyped ACMSD tag single-nucleotide polymorphisms (SNPs) in 77 of the patients and 150 population-based controls. Suicide attempters had reduced PIC and a decreased PIC/QUIN ratio in both CSF (P<0.001) and blood (P=0.001 and P<0.01, respectively). The reductions of PIC in CSF were sustained over 2 years after the suicide attempt based on repeated measures. The minor C allele of the ACMSD SNP rs2121337 was more prevalent in suicide attempters and associated with increased CSF QUIN. Taken together, our data suggest that increased QUIN levels may result from reduced activity of ACMSD in suicidal subjects. We conclude that measures of kynurenine metabolites can be explored as biomarkers of suicide risk, and that ACMSD is a potential therapeutic target in suicidal behavior. PMID:27483383

  12. ESTABLISHING FINAL END STATE FOR A RETIRED NUCLEAR WEAPONS PRODUCTION REACTOR; COLLABORATION BETWEEN STAKEHOLDERS, REGULATORS, AND THE FEDERAL GOVERNMENT - 11052

    SciTech Connect

    Bergren, C.; Flora, M.; Belencan, H.

    2010-11-17

    The Savannah River Site (SRS) is a 310-square-mile United States Department of Energy nuclear facility located along the Savannah River (SRS) near Aiken, South Carolina. Nuclear weapons material production began in the early 1950s, utilizing five production reactors. In the early 1990s all SRS production reactor operations were terminated. The first reactor closure end state declaration was recently institutionalized in a Comprehensive Environmental Response and Compensation and Liability Act (CERCLA) Early Action Record of Decision. The decision for the final closure of the 318,000 square foot 105-P Reactor was determined to be in situ decommissioning (ISD). ISD is an acceptable and cost effective alternative to off-site disposal for the reactor building, which will allow for consolidation of remedial action wastes generated from other cleanup activities within the P Area. ISD is considered protective by the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), public and stakeholders as waste materials are stabilized/immobilized, and radioactivity is allowed to naturally decay, thus preventing future exposure to the environment. Stakeholder buy-in was critical in the upfront planning in order to achieve this monumental final decision. Numerous public meetings and workshops were held in two different states (covering a 200 mile radius) with stakeholder and SRS Citizens Advisory Board participation. These meetings were conducted over an eight month period as the end state decision making progressed. Information provided to the public evolved from workshop to workshop as data became available and public input from the public meetings were gathered. ISD is being considered for the balance of the four SRS reactors and other hardened facilities such as the chemical Separation Facilities (canyons).

  13. ESTABLISHING FINAL END STATE FOR A RETIRED NUCLEAR WEAPONS PRODUCTION REACTOR; COLLABORATION BETWEEN STAKEHOLDERS, REGULATORS AND THE FEDERAL GOVERNMENT

    SciTech Connect

    Bergren, C

    2009-01-16

    The Savannah River Site (SRS) is a 310-square-mile United States Department of Energy nuclear facility located along the Savannah River (SRS) near Aiken, South Carolina. Nuclear weapons material production began in the early 1950s, utilizing five production reactors. In the early 1990s all SRS production reactor operations were terminated. The first reactor closure end state declaration was recently institutionalized in a Comprehensive Environmental Response and Compensation and Liability Act (CERCLA) Early Action Record of Decision. The decision for the final closure of the 318,000 square foot 105-P Reactor was determined to be in situ decommissioning (ISD). ISD is an acceptable and cost effective alternative to off-site disposal for the reactor building, which will allow for consolidation of remedial action wastes generated from other cleanup activities within the P Area. ISD is considered protective by the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), public and stakeholders as waste materials are stabilized/immobilized, and radioactivity is allowed to naturally decay, thus preventing future exposure to the environment. Stakeholder buy-in was critical in the upfront planning in order to achieve this monumental final decision. Numerous public meetings and workshops were held in two different states (covering a 200 mile radius) with stakeholder and SRS Citizens Advisory Board participation. These meetings were conducted over an eight month period as the end state decision making progressed. Information provided to the public evolved from workshop to workshop as data became available and public input from the public meetings were gathered. ISD is being considered for the balance of the four SRS reactors and other hardened facilities such as the chemical processing canyons.

  14. The master regulator for biofilm formation in Bacillus subtilis governs the expression of an operon encoding secreted proteins required for the assembly of complex multicellular communities.

    SciTech Connect

    Branda, Steven S.; Losick, Richard; Kolter, Roberto; Kearns, Daniel B.; Chu, Frances

    2005-08-01

    Wild strains of Bacillus subtilis are capable of forming architecturally complex communities of cells known as biofilms. Critical to biofilm formation is the eps operon, which is believed to be responsible for the biosynthesis of an exopolysaccharide that binds chains of cells together in bundles. We report that transcription of eps is under the negative regulation of SinR, a repressor that was found to bind to multiple sites in the regulatory region of the operon. Mutations in sinR bypassed the requirement in biofilm formation of two genes of unknown function, ylbF and ymcA, and sinI, which is known to encode an antagonist of SinR. We propose that these genes are members of a pathway that is responsible for counteracting SinR-mediated repression. We further propose that SinR is a master regulator that governs the transition between a planktonic state in which the bacteria swim as single cells in liquid or swarm in small groups over surfaces, and a sessile state in which the bacteria adhere to each other to form bundled chains and assemble into multicellular communities.

  15. The case for OFSMOKE: how tobacco price regulation is needed to promote the health of markets, government revenue and the public

    PubMed Central

    Branston, J Robert; Sweanor, David

    2010-01-01

    Mainstream economic theory outlines four main causes of market failure and it is already well established that two of these (information failure and externalities) exist in a tobacco market. A third cause of market failure, market power, is also a serious problem in many tobacco markets. Market power—combined with unintended and often overlooked consequences of tobacco tax policies, notably that gradual increases in specific taxes may allow the industry to disguise significant price increases—has, at least in high income countries, given cigarette manufacturers considerable pricing power and profits. This paper examines ways this market failure could be addressed and proposes as a solution a system of price cap regulation wherein a cap is placed on the pre-tax cigarette manufacturers' price but not on the retail price that consumers face. Well established in the utilities industry, price cap regulation would set a maximum price that cigarette companies can charge for their product based on an assessment of the genuine costs each firm faces in its operations and an assumption about the efficiency savings it would be expected to make. Such a system would achieve three main benefits. First, it would address the problem of market failure and excess profits while simultaneously allowing current tobacco control policies, including tax and price increases, to expand—thus tax increases would remain a central tenet of tobacco control policies and retail prices could continue to increase. Second, it would increase government revenue by transferring the excess profits from the industry to the government purse. Third, it would bring numerous public health benefits. In addition to addressing market power, while simultaneously allowing tobacco control policies to expand, it could offer a means of preventing down-trading to cheaper products and controlling unwanted industry practices such as cigarette smuggling, price fixing and marketing to the young. The paper outlines in

  16. The case for OFSMOKE: how tobacco price regulation is needed to promote the health of markets, government revenue and the public.

    PubMed

    Gilmore, Anna B; Branston, J Robert; Sweanor, David

    2010-10-01

    Mainstream economic theory outlines four main causes of market failure and it is already well established that two of these (information failure and externalities) exist in a tobacco market. A third cause of market failure, market power, is also a serious problem in many tobacco markets. Market power--combined with unintended and often overlooked consequences of tobacco tax policies, notably that gradual increases in specific taxes may allow the industry to disguise significant price increases--has, at least in high income countries, given cigarette manufacturers considerable pricing power and profits. This paper examines ways this market failure could be addressed and proposes as a solution a system of price cap regulation wherein a cap is placed on the pre-tax cigarette manufacturers' price but not on the retail price that consumers face. Well established in the utilities industry, price cap regulation would set a maximum price that cigarette companies can charge for their product based on an assessment of the genuine costs each firm faces in its operations and an assumption about the efficiency savings it would be expected to make. Such a system would achieve three main benefits. First, it would address the problem of market failure and excess profits while simultaneously allowing current tobacco control policies, including tax and price increases, to expand--thus tax increases would remain a central tenet of tobacco control policies and retail prices could continue to increase. Second, it would increase government revenue by transferring the excess profits from the industry to the government purse. Third, it would bring numerous public health benefits. In addition to addressing market power, while simultaneously allowing tobacco control policies to expand, it could offer a means of preventing down-trading to cheaper products and controlling unwanted industry practices such as cigarette smuggling, price fixing and marketing to the young. The paper outlines in

  17. The case for OFSMOKE: how tobacco price regulation is needed to promote the health of markets, government revenue and the public.

    PubMed

    Gilmore, Anna B; Branston, J Robert; Sweanor, David

    2010-10-01

    Mainstream economic theory outlines four main causes of market failure and it is already well established that two of these (information failure and externalities) exist in a tobacco market. A third cause of market failure, market power, is also a serious problem in many tobacco markets. Market power--combined with unintended and often overlooked consequences of tobacco tax policies, notably that gradual increases in specific taxes may allow the industry to disguise significant price increases--has, at least in high income countries, given cigarette manufacturers considerable pricing power and profits. This paper examines ways this market failure could be addressed and proposes as a solution a system of price cap regulation wherein a cap is placed on the pre-tax cigarette manufacturers' price but not on the retail price that consumers face. Well established in the utilities industry, price cap regulation would set a maximum price that cigarette companies can charge for their product based on an assessment of the genuine costs each firm faces in its operations and an assumption about the efficiency savings it would be expected to make. Such a system would achieve three main benefits. First, it would address the problem of market failure and excess profits while simultaneously allowing current tobacco control policies, including tax and price increases, to expand--thus tax increases would remain a central tenet of tobacco control policies and retail prices could continue to increase. Second, it would increase government revenue by transferring the excess profits from the industry to the government purse. Third, it would bring numerous public health benefits. In addition to addressing market power, while simultaneously allowing tobacco control policies to expand, it could offer a means of preventing down-trading to cheaper products and controlling unwanted industry practices such as cigarette smuggling, price fixing and marketing to the young. The paper outlines in

  18. To Government Regulations Be True.

    ERIC Educational Resources Information Center

    Gardner, Carrie

    2002-01-01

    Describes school-district compliance requirements for two recently enacted federal laws designed to protect children from obscene, pornographic, or harmful materials available on the Internet: Children's Internet Protection Act and Neighborhood Children's Internet Protection Act. District eligibility for federal funds, including the E-rate…

  19. Student Government.

    ERIC Educational Resources Information Center

    Morrow, Joyce

    Materials for running a student government program at the junior high school level are provided in three general sections. Section 1 is a description of student government operations. Topics covered include student government responsibilities and activities, student council meeting procedures, parliamentary rules, responsibilities of the…

  20. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  1. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  2. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  3. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  4. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  5. Representation and Misrepresentation of Scientific Evidence in Contemporary Tobacco Regulation: A Review of Tobacco Industry Submissions to the UK Government Consultation on Standardised Packaging

    PubMed Central

    Ulucanlar, Selda; Fooks, Gary J.; Hatchard, Jenny L.; Gilmore, Anna B.

    2014-01-01

    Background Standardised packaging (SP) of tobacco products is an innovative tobacco control measure opposed by transnational tobacco companies (TTCs) whose responses to the UK government's public consultation on SP argued that evidence was inadequate to support implementing the measure. The government's initial decision, announced 11 months after the consultation closed, was to wait for ‘more evidence’, but four months later a second ‘independent review’ was launched. In view of the centrality of evidence to debates over SP and TTCs' history of denying harms and manufacturing uncertainty about scientific evidence, we analysed their submissions to examine how they used evidence to oppose SP. Methods and Findings We purposively selected and analysed two TTC submissions using a verification-oriented cross-documentary method to ascertain how published studies were used and interpretive analysis with a constructivist grounded theory approach to examine the conceptual significance of TTC critiques. The companies' overall argument was that the SP evidence base was seriously flawed and did not warrant the introduction of SP. However, this argument was underpinned by three complementary techniques that misrepresented the evidence base. First, published studies were repeatedly misquoted, distorting the main messages. Second, ‘mimicked scientific critique’ was used to undermine evidence; this form of critique insisted on methodological perfection, rejected methodological pluralism, adopted a litigation (not scientific) model, and was not rigorous. Third, TTCs engaged in ‘evidential landscaping’, promoting a parallel evidence base to deflect attention from SP and excluding company-held evidence relevant to SP. The study's sample was limited to sub-sections of two out of four submissions, but leaked industry documents suggest at least one other company used a similar approach. Conclusions The TTCs' claim that SP will not lead to public health benefits is largely

  6. Governance and Institutional Autonomy: Governing and Governance in Portuguese Higher Education

    ERIC Educational Resources Information Center

    Magalhaes, Antonio; Veiga, Amelia; Ribeiro, Filipa; Amaral, Alberto

    2013-01-01

    This paper aims at looking at governance instruments beyond managerial technicality. It intends to do so by analysing the impact of governance reforms on the universities autonomy assumed as a regulation instrument to politically steer systems and institutions. The regulation efforts undertaken at the European and national levels reflect a trend…

  7. 48 CFR 246.470 - Government contract quality assurance actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government contract... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.470 Government contract quality assurance actions....

  8. 48 CFR 246.470 - Government contract quality assurance actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government contract... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.470 Government contract quality assurance actions....

  9. 48 CFR 246.470 - Government contract quality assurance actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government contract... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.470 Government contract quality assurance actions....

  10. 48 CFR 246.470 - Government contract quality assurance actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government contract... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.470 Government contract quality assurance actions....

  11. 48 CFR 246.470 - Government contract quality assurance actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government contract... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.470 Government contract quality assurance actions....

  12. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  13. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  14. 48 CFR 45.602 - Reutilization of Government property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Government property. 45.602 Section 45.602 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 45.602 Reutilization of Government property. This section is applicable to the reutilization, including transfer...

  15. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  16. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  17. Reinventing Government.

    ERIC Educational Resources Information Center

    Osborne, David T.

    1993-01-01

    Throughout all levels of American government, a shift is taking place from the rigid, wasteful, centralized bureaucracies of the industrial era to the more flexible, entrepreneurial, decentralized government needed to succeed in today's world. This shift has been brought about by an unprecedented, ongoing fiscal crisis that has created a sudden…

  18. Remaking Governance.

    ERIC Educational Resources Information Center

    Carver, John

    2000-01-01

    The Policy Governance model's philosophical foundations lie in Rousseau's social contract, Greenleaf's servant-leadership, and modern management theory. Policy Governance stresses primacy of the owner-representative role; full-board authority; superintendents as chief executive officers; authoritative prescription of "ends," bounded freedom for…

  19. Policing Governance.

    ERIC Educational Resources Information Center

    Schuster, Jack H.

    1991-01-01

    The American Association of University Professors' (AAUP) new policy authorizing sanctions against colleges when investigation discloses serious departures from accepted governance norms is examined. Issues discussed include the existence and general relevance of governance norms, evidence of violation of those standards, and the AAUP's right to…

  20. 31 CFR 575.304 - Entity of the Government of Iraq; Iraqi Government entity.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Entity of the Government of Iraq... SANCTIONS REGULATIONS General Definitions § 575.304 Entity of the Government of Iraq; Iraqi Government entity. The term entity of the Government of Iraq or Iraqi Government entity includes: (a)...

  1. Biology and the Government

    ERIC Educational Resources Information Center

    Reid, Roger D.

    1969-01-01

    Emphasizes the social implications of biological knowledge and discusses two main government roles in biology: (1) a creative and supportive role, including support of education and research, (2) control, regulation and protection related to the applications of biological knowledge. Public control is considered necessary in areas such as food and…

  2. Globalization and emerging governance modalities.

    PubMed

    Neubauer, Deane Edward

    2005-09-01

    This paper explores the possibilities for global governance effectively dealing with the international transmission of disease. First, zoonotic regulation and control pose a special case for public health agencies, and this paper proposes a propositional model for an effective public health stance. Second, globalization dynamics are briefly reviewed in terms of an emerging consensus on the need for global governance in public health. Third, a brief examination of global governance modalities suggests that a strong global governance case has distinct limitations (despite its possible justification); an exploration of contemporary directions in global governance follows. Finally, the paper examines the phenomenon of contemporary zoonotic control within the conditions of an effective regulatory regime.

  3. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Government delay of work. 42.1304 Section 42.1304 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay...

  4. 48 CFR 1815.207-71 - Appointing non-Government evaluators as special Government employees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... evaluators as special Government employees. 1815.207-71 Section 1815.207-71 Federal Acquisition Regulations...-Government evaluators as special Government employees. (a) Except as provided in paragraph (c) of this section, non-Government evaluators, except employees of JPL, shall be appointed as special...

  5. 48 CFR 1815.207-71 - Appointing non-Government evaluators as special Government employees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... evaluators as special Government employees. 1815.207-71 Section 1815.207-71 Federal Acquisition Regulations...-Government evaluators as special Government employees. (a) Except as provided in paragraph (c) of this section, non-Government evaluators, except employees of JPL, shall be appointed as special...

  6. 48 CFR 945.602 - Reutilization of Government property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government property. 945.602 Section 945.602 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.602 Reutilization of Government property....

  7. 48 CFR 945.602 - Reutilization of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government property. 945.602 Section 945.602 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.602 Reutilization of Government property....

  8. The Aspergillus fumigatus StuA Protein Governs the Up-Regulation of a Discrete Transcriptional Program during the Acquisition of Developmental CompetenceD⃞

    PubMed Central

    Sheppard, Donald C.; Doedt, Thomas; Chiang, Lisa Y.; Kim, H. Stanley; Chen, Dan; Nierman, William C.; Filler, Scott G.

    2005-01-01

    Members of the Asm1p, Phd1p, Sok2p, Efg1p, and StuAp (APSES) family of fungal proteins regulate morphogenesis and virulence in ascomycetes. We cloned the Aspergillus fumigatus APSES gene encoding StuAp and demonstrated that stuA transcription is markedly up-regulated after the acquisition of developmental competence. A. fumigatus ΔstuA mutants were impaired in their ability to undergo asexual reproduction. Conidiophore morphology was markedly abnormal, and only small numbers of dysmorphic conidia were produced, which exhibited precocious germination. Whole genome transcriptional analysis during the onset of developmental competence was performed and identified a subset of developmentally regulated genes that were stuA dependent, including a cluster of putative secondary metabolite biosynthesis genes, genes encoding proteins implicated in the regulation of morphogenesis, and genes encoding allergens and other antigenic proteins. Additionally, hyphae of the ΔstuA mutant displayed reduced expression of the catalase gene CAT1 and were hypersusceptible to hydrogen peroxide. PMID:16207816

  9. 48 CFR 42.705-4 - State and local governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... governments. 42.705-4 Section 42.705-4 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... governments. OMB Circular No. A-87 concerning cost principles for state and local governments (see subpart 31... approving state and local government indirect costs associated with federally-funded programs and...

  10. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government-to-government agreements. 225.7303-3 Section 225.7303-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Acquisitions for...

  11. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government-to-government agreements. 225.7303-3 Section 225.7303-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Acquisitions for...

  12. Earthquake resistant construction of gas and liquid fuel pipeline systems serving, or regulated by, the Federal government. Earthquake hazard reduction series No. 67

    SciTech Connect

    Yokel, F.Y.; Mathey, R.G.

    1992-07-01

    The vulnerability of gas and liquid fuel pipeline systems to damage in past earthquakes, as well as available standards and technologies that can protect these facilities against earthquake damage are reviewed. An overview is presented of measures taken by various Federal Agencies to protect pipeline systems under their jurisdiction against earthquake hazards. It is concluded that the overall performance of pipeline systems in past earthquakes was relatively good, however, older pipelines and above-ground storage tanks were damaged in many earthquakes. Standards and regulations for liquid fuel pipelines contain only general references to seismic loads. Standards and regulations for above-ground fuel storage tanks and for liquefied natural gas facilities contain explicit seismic design provisions. It is recommended that a guideline for earthquake resistant design of gas and liquid fuel pipeline systems be prepared for Federal Agencies to ensure a uniform approach to the protection of these systems.

  13. Identification of a c-di-GMP-regulated polysaccharide locus governing stress resistance and biofilm and rugose colony formation in Vibrio vulnificus.

    PubMed

    Guo, Yunzhi; Rowe-Magnus, Dean A

    2010-03-01

    As an etiological agent of bacterial sepsis and wound infections, Vibrio vulnificus is unique among the Vibrionaceae. Its continued environmental persistence and transmission are bolstered by its ability to colonize shellfish, form biofilms on various marine biotic surfaces, and generate a morphologically and physiologically distinct rugose (R) variant that yields profuse biofilms. Here, we identify a c-di-GMP-regulated locus (brp, for biofilm and rugose polysaccharide) and two transcription factors (BrpR and BrpT) that regulate these physiological responses. Disruption of glycosyltransferases within the locus or either regulator abated the inducing effect of c-di-GMP on biofilm formation, rugosity, and stress resistance. The same lesions, or depletion of intracellular c-di-GMP levels, abrogated these phenotypes in the R variant. The parental and brp mutant strains formed only scant monolayers on glass surfaces and oyster shells, and although the R variant formed expansive biofilms, these were of limited depth. Dramatic vertical expansion of the biofilm structure was observed in the parental strain and R variant, but not the brp mutants, when intracellular c-di-GMP levels were elevated. Hence, the brp-encoded polysaccharide is important for surface colonization and stress resistance in V. vulnificus, and its expression may control how the bacteria switch from a planktonic lifestyle to colonizing shellfish to invading human tissue.

  14. 16 CFR 460.21 - Government claims.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Government claims. 460.21 Section 460.21 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF HOME INSULATION § 460.21 Government claims. Do not say or imply that a government agency uses,...

  15. 16 CFR 460.21 - Government claims.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Government claims. 460.21 Section 460.21 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF HOME INSULATION § 460.21 Government claims. Do not say or imply that a government agency uses,...

  16. 16 CFR 460.21 - Government claims.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Government claims. 460.21 Section 460.21 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF HOME INSULATION § 460.21 Government claims. Do not say or imply that a government agency uses,...

  17. 16 CFR 460.21 - Government claims.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Government claims. 460.21 Section 460.21 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF HOME INSULATION § 460.21 Government claims. Do not say or imply that a government agency uses,...

  18. 16 CFR 460.21 - Government claims.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Government claims. 460.21 Section 460.21 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF HOME INSULATION § 460.21 Government claims. Do not say or imply that a government agency uses,...

  19. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  20. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  1. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  2. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  3. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  4. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  5. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  6. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  7. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  8. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  9. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  10. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  11. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  12. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  13. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  14. 42 CFR 494.180 - Condition: Governance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... governing body, or designated person(s) with full legal authority and responsibility for the governance and operation of the facility. The governing body adopts and enforces rules and regulations relative to its...

  15. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government...

  16. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  17. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government...

  18. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government...

  19. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  20. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  1. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government...

  2. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  3. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property to... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government...

  4. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to the... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government...

  5. Government Action in Universities and Colleges.

    ERIC Educational Resources Information Center

    Loftus, Elizabeth F.

    The Federal Government seeks to achieve a multitude of objectives that concern the academic and scientific community. Setting aside the issue of whether the government should be regulating everything from birth control to rat control, and whether the regulations should be improved or clarified, a major question is: why piggyback the government…

  6. Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity

    PubMed Central

    Long, Mark D.; van den Berg, Patrick R.; Russell, James L.; Singh, Prashant K.; Battaglia, Sebastiano; Campbell, Moray J.

    2015-01-01

    To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinations (24/44) were associated with significantly elevated level expression of protein coding genes and only very few combinations related to gene repression. DAVID's biological process annotation revealed that elevated gene expression was uniquely associated with acetylation and ETS binding. A matrix of gene and drug interactions built on NCI-60 data identified that Imatinib significantly targeted the NCOR1 governed transcriptome. Stable knockdown of NCOR1 in K562 cells slowed growth and significantly repressed genes associated with NCOR1 cistrome, again, with the GO terms acetylation and ETS binding, and significantly dampened sensitivity to Imatinib-induced erythroid differentiation. Mining public microarray data revealed that NCOR1-targeted genes were significantly enriched in Imatinib response gene signatures in cell lines and chronic myelogenous leukemia (CML) patients. These approaches integrated cistrome, transcriptome and drug sensitivity relationships to reveal that NCOR1 function is surprisingly most associated with elevated gene expression, and that these targets, both in CML cell lines and patients, associate with sensitivity to Imatinib. PMID:26117541

  7. Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity.

    PubMed

    Long, Mark D; van den Berg, Patrick R; Russell, James L; Singh, Prashant K; Battaglia, Sebastiano; Campbell, Moray J

    2015-09-01

    To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinations (24/44) were associated with significantly elevated level expression of protein coding genes and only very few combinations related to gene repression. DAVID's biological process annotation revealed that elevated gene expression was uniquely associated with acetylation and ETS binding. A matrix of gene and drug interactions built on NCI-60 data identified that Imatinib significantly targeted the NCOR1 governed transcriptome. Stable knockdown of NCOR1 in K562 cells slowed growth and significantly repressed genes associated with NCOR1 cistrome, again, with the GO terms acetylation and ETS binding, and significantly dampened sensitivity to Imatinib-induced erythroid differentiation. Mining public microarray data revealed that NCOR1-targeted genes were significantly enriched in Imatinib response gene signatures in cell lines and chronic myelogenous leukemia (CML) patients. These approaches integrated cistrome, transcriptome and drug sensitivity relationships to reveal that NCOR1 function is surprisingly most associated with elevated gene expression, and that these targets, both in CML cell lines and patients, associate with sensitivity to Imatinib.

  8. Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8α⁺ semi-invariant T cells.

    PubMed

    Turtle, Cameron J; Delrow, Jeff; Joslyn, Rochelle C; Swanson, Hillary M; Basom, Ryan; Tabellini, Laura; Delaney, Colleen; Heimfeld, Shelly; Hansen, John A; Riddell, Stanley R

    2011-09-01

    Type 17 programmed CD161(hi)CD8α(+) T cells contribute to mucosal immunity to bacteria and yeast. In early life, microbial colonization induces proliferation of CD161(hi) cells that is dependent on their expression of a semi-invariant Vα7.2(+) TCR. Although prevalent in adults, CD161(hi)CD8α(+) cells exhibit weak proliferative and cytokine responses to TCR ligation. The mechanisms responsible for the dichotomous response of neonatal and adult CD161(hi) cells, and the signals that enable their effector function, have not been established. We describe acquired regulation of TCR signaling in adult memory CD161(hi)CD8α(+) T cells that is absent in cord CD161(hi) cells and adult CD161(lo) cells. Regulated TCR signaling in CD161(hi) cells was due to profound alterations in TCR signaling pathway gene expression and could be overcome by costimulation through CD28 or innate cytokine receptors, which dictated the fate of their progeny. Costimulation with IL-1β during TCR ligation markedly increased proinflammatory IL-17 production, while IL-12-induced Tc1-like function and restored the response to TCR ligation without costimulation. CD161(hi) cells from umbilical cord blood and granulocyte colony stimulating factor-mobilized leukaphereses differed in frequency and function, suggesting future evaluation of the contribution of CD161(hi) cells in hematopoietic stem cell grafts to transplant outcomes is warranted.

  9. A Nucleus-Encoded Chloroplast Protein Regulated by Iron Availability Governs Expression of the Photosystem I Subunit PsaA in Chlamydomonas reinhardtii1

    PubMed Central

    Lefebvre-Legendre, Linnka; Choquet, Yves; Kuras, Richard; Loubéry, Sylvain; Douchi, Damien; Goldschmidt-Clermont, Michel

    2015-01-01

    The biogenesis of the photosynthetic electron transfer chain in the thylakoid membranes requires the concerted expression of genes in the chloroplast and the nucleus. Chloroplast gene expression is subjected to anterograde control by a battery of nucleus-encoded proteins that are imported in the chloroplast, where they mostly intervene at posttranscriptional steps. Using a new genetic screen, we identify a nuclear mutant that is required for expression of the PsaA subunit of photosystem I (PSI) in the chloroplast of Chlamydomonas reinhardtii. This mutant is affected in the stability and translation of psaA messenger RNA. The corresponding gene, TRANSLATION OF psaA1 (TAA1), encodes a large protein with two domains that are thought to mediate RNA binding: an array of octatricopeptide repeats (OPR) and an RNA-binding domain abundant in apicomplexans (RAP) domain. We show that as expected for its function, TAA1 is localized in the chloroplast. It was previously shown that when mixotrophic cultures of C. reinhardtii (which use both photosynthesis and mitochondrial respiration for growth) are shifted to conditions of iron limitation, there is a strong decrease in the accumulation of PSI and that this is rapidly reversed when iron is resupplied. Under these conditions, TAA1 protein is also down-regulated through a posttranscriptional mechanism and rapidly reaccumulates when iron is restored. These observations reveal a concerted regulation of PSI and of TAA1 in response to iron availability. PMID:25673777

  10. 48 CFR 246.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of Government contract quality assurance. 246.408 Section 246.408 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.408 Single-agency assignments of Government...

  11. 48 CFR 46.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of Government contract quality assurance. 46.408 Section 46.408 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.408 Single-agency assignments of Government contract quality assurance. (a)...

  12. 48 CFR 46.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of Government contract quality assurance. 46.408 Section 46.408 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.408 Single-agency assignments of Government contract quality assurance. (a)...

  13. 48 CFR 246.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... of Government contract quality assurance. 246.408 Section 246.408 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.408 Single-agency assignments of Government...

  14. 48 CFR 246.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of Government contract quality assurance. 246.408 Section 246.408 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.408 Single-agency assignments of Government...

  15. 48 CFR 46.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of Government contract quality assurance. 46.408 Section 46.408 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.408 Single-agency assignments of Government contract quality assurance. (a)...

  16. 48 CFR 246.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... of Government contract quality assurance. 246.408 Section 246.408 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.408 Single-agency assignments of Government...

  17. 48 CFR 46.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of Government contract quality assurance. 46.408 Section 46.408 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.408 Single-agency assignments of Government contract quality assurance. (a)...

  18. 48 CFR 46.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... of Government contract quality assurance. 46.408 Section 46.408 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.408 Single-agency assignments of Government contract quality assurance. (a)...

  19. 48 CFR 246.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... of Government contract quality assurance. 246.408 Section 246.408 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.408 Single-agency assignments of Government...

  20. Characterization of the cis elements in the proximal promoter regions of the anthocyanin pathway genes reveals a common regulatory logic that governs pathway regulation

    PubMed Central

    Zhu, Zhixin; Wang, Hailong; Wang, Yiting; Guan, Shan; Wang, Fang; Tang, Jingyu; Zhang, Ruijuan; Xie, Lulu; Lu, Yingqing

    2015-01-01

    Cellular activities such as compound synthesis often require the transcriptional activation of an entire pathway; however, the molecular mechanisms underlying pathway activation have rarely been explained. Here, the cis regulatory architecture of the anthocyanin pathway genes targeted by the transcription factor (TF) complex including MYB, bHLH, and WDR was systematically analysed in one species and the findings extended to others. In Ipomoea purpurea, the IpMYB1-IpbHLH2-IpWDR1 (IpMBW) complex was found to be orthologous to the PAP1-GL3-TTG1 (AtPGT) complex of Arabidopsis thaliana, and interacted with a 7-bp MYB-recognizing element (MRE) and a 6-bp bHLH-recognizing element (BRE) at the proximal promoter region of the pathway genes. There was little transcription of the gene in the absence of the MRE or BRE. The cis elements identified experimentally converged on two syntaxes, ANCNNCC for MREs and CACN(A/C/T)(G/T) for BREs, and our bioinformatic analysis showed that these were present within anthocyanin gene promoters in at least 35 species, including both gymnosperms and angiosperms. For the anthocyanin pathway, IpMBW and AtPGT recognized the interspecific promoters of both early and later genes. In A. thaliana, the seed-specific TF complex (TT2, TT8, and TTG1) may regulate all the anthocyanin pathway genes, in addition to the proanthocyanidin-specific BAN. When multiple TF complexes in the anthocyanin pathway were compared, the cis architecture played a role larger than the TF complex in determining the variation in promoter activity. Collectively, a cis logic common to the pathway gene promoters was found, and this logic is essential for the trans factors to regulate the pathway. PMID:25911741

  1. Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.

    PubMed

    Kowalczyk, Katarzyna M; Petersen, Janni

    2016-05-01

    Target of Rapamycin (TOR) signalling allows eukaryotic cells to adjust cell growth in response to changes in their nutritional and environmental context. The two distinct TOR complexes (TORC1/2) localise to the cell's internal membrane compartments; the endoplasmic reticulum (ER), Golgi apparatus and lysosomes/vacuoles. Here, we show that Ppk32, a SCYL family pseudo-kinase, is a novel regulator of TOR signalling. The absence of ppk32 expression confers resistance to TOR inhibition. Ppk32 inhibition of TORC1 is critical for cell survival following Brefeldin A (BFA) induced stress. Treatment of wild type cells with either the TORC1 specific inhibitor rapamycin or the general TOR inhibitor Torin1 confirmed that a reduction in TORC1 activity promoted recovery from BFA induced stress. Phosphorylation of Ppk32 on two residues that are conserved within the SCYL pseudo-kinase family are required for this TOR inhibition. Phosphorylation on these sites controls Ppk32 protein levels and sensitivity to BFA. BFA induced ER stress does not account for the response to BFA that we report here, however BFA is also known to induce Golgi stress and impair traffic to lysosomes. In summary, Ppk32 reduce TOR signalling in response to BFA induced stress to support cell survival.

  2. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking.

    PubMed

    Mangasarian, A; Piguet, V; Wang, J K; Chen, Y L; Trono, D

    1999-03-01

    The Nef protein of primate lentiviruses triggers the accelerated endocytosis of CD4 and of class I major histocompatibility complex (MHC-I), thereby down-modulating the cell surface expression of these receptors. Nef acts as a connector between the CD4 cytoplasmic tail and intracellular sorting pathways both in the Golgi and at the plasma membrane, triggering the de novo formation of CD4-specific clathrin-coated pits (CCP). The downstream partners of Nef in this event are the adapter protein complex (AP) of CCP and possibly a subunit of the vacuolar ATPase. Whether Nef-induced MHC-I down-regulation stems from a similar mechanism is unknown. By comparing human immunodeficiency virus type 1 (HIV-1) Nef mutants for their ability to affect either CD4 or MHC-I expression, both in transient-transfection assays and in the context of HIV-1 infection, it was determined that Nef-induced CD4 and MHC-I down-regulation constitute genetically and functionally separate properties. Mutations affecting only CD4 regulation mapped to residues previously shown to mediate the binding of Nef to this receptor, such as W57 and L58, as well as to an AP-recruiting dileucine motif and to an acidic dipeptide in the C-terminal region of the protein. In contrast, mutation of residues in an alpha-helical region in the proximal portion of Nef and amino acid substitutions in a proline-based SH3 domain-binding motif selectively affected MHC-I down-modulation. Although both the N-terminal alpha-helix and the proline-rich region of Nef have been implicated in recruiting Src family protein kinases, the inhibitor herbimycin A did not block MHC-I down-regulation, suggesting that the latter process is not mediated through an activation of this family of tyrosine kinases. PMID:9971776

  3. Achieving Accelerated Cleanup of Cesium Contaminated Stream at the Savannah River Site; Collaboration between Stakeholders, Regulators, and the Federal Government - 13182

    SciTech Connect

    Bergren, Chris; Flora, Mary; Socha, Ron; Burch, Joseph; Freeman, Candice; Hennessey, Brian

    2013-07-01

    's stakeholders including the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), and the public including local property owners and the SRS Citizens Advisory Board. Stakeholder buy-in was critical in the up-front planning in order to achieve this challenging cleanup. (authors)

  4. Do Kids Need Government Censors?

    ERIC Educational Resources Information Center

    Rabkin, Rhoda

    2002-01-01

    Fashioning public policies restricting children's access to entertainment glamorizing violence, sex, drugs, and vulgarity is a complex task. The recently introduced Media Marketing Accountability Act would empower the federal government to regulate advertising of entertainment products to youth. Suggests that this power is undesirable compared to…

  5. Refocusing Government-Communications Policy.

    ERIC Educational Resources Information Center

    Pool, Ithiel de Sola; And Others

    In 1976, the Aspen Institute's Program on Communications and Society sponsored a series of Washington staff seminars on communications policy: "Policy Choices for the Information Age,""Government Telecommunications Research and Policy Development,""Problems of Regulating Specialized Telecommunications Common Carriers," and "Public Service Uses of…

  6. 48 CFR 951.103 - Ordering from Government supply sources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Ordering from Government supply sources. 951.103 Section 951.103 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Government Supply...

  7. 48 CFR 945.170 - Providing Government property to contractors.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Providing Government property to contractors. 945.170 Section 945.170 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 945.170 Providing Government property...

  8. 48 CFR 945.170 - Providing Government property to contractors.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Providing Government property to contractors. 945.170 Section 945.170 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 945.170 Providing Government property...

  9. 48 CFR 1845.502-1 - Receipts for Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Receipts for Government property. 1845.502-1 Section 1845.502-1 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in...

  10. 48 CFR 2845.105 - Records of Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Records of Government property. 2845.105 Section 2845.105 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Contract Management GOVERNMENT PROPERTY General 2845.105 Records of Government property. If departmental...

  11. 48 CFR 2045.370 - Providing Government property (in general).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Providing Government property (in general). 2045.370 Section 2045.370 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION CONTRACT MANAGEMENT GOVERNMENT PROPERTY Providing Government Property to Contractors...

  12. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Report of Government Property. 2845.505-14 Section 2845.505-14 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE Contract Management GOVERNMENT PROPERTY Management of Government Property in the Possession of...

  13. 48 CFR 951.103 - Ordering from Government supply sources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Ordering from Government supply sources. 951.103 Section 951.103 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT USE OF GOVERNMENT SOURCES BY CONTRACTORS Contractor Use of Government Supply...

  14. 48 CFR 32.503-14 - Protection of Government title.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... title. 32.503-14 Section 32.503-14 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... of Government title. (a) Since the Progress Payments clause gives the Government title to all of the... ensure that the Government title to these inventories is not compromised by other...

  15. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  16. 48 CFR 27.305-2 - Administration by the Government.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Government. 27.305-2 Section 27.305-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305-2 Administration by the Government. (a) Agencies should establish and maintain appropriate...

  17. 48 CFR 245.103-71 - Transferring Government property accountability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Transferring Government... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.103-71 Transferring Government property accountability. Follow the procedures at PGI 245.103-71...

  18. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  19. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  20. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  1. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  2. 5 CFR 2635.704 - Use of Government property.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... regulation. Example 1: Under regulations of the General Services Administration at 41 CFR 101-35.201, an... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Use of Government property. 2635.704 Section 2635.704 Administrative Personnel OFFICE OF GOVERNMENT ETHICS GOVERNMENT ETHICS STANDARDS...

  3. 48 CFR 245.103-71 - Transferring Government property accountability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Transferring Government... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.103-71 Transferring Government property accountability. Follow the procedures at PGI 245.103-71...

  4. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  5. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  6. 14 CFR 221.63 - Other types of governing tariffs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Other types of governing tariffs. 221.63... PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.63 Other types of governing tariffs. Subject to approval of the Department, carriers may publish other types of governing tariffs not specified...

  7. 14 CFR 221.63 - Other types of governing tariffs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Other types of governing tariffs. 221.63... PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.63 Other types of governing tariffs. Subject to approval of the Department, carriers may publish other types of governing tariffs not specified...

  8. 14 CFR 221.63 - Other types of governing tariffs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Other types of governing tariffs. 221.63... PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.63 Other types of governing tariffs. Subject to approval of the Department, carriers may publish other types of governing tariffs not specified...

  9. 14 CFR 221.63 - Other types of governing tariffs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Other types of governing tariffs. 221.63... PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.63 Other types of governing tariffs. Subject to approval of the Department, carriers may publish other types of governing tariffs not specified...

  10. 14 CFR 221.63 - Other types of governing tariffs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Other types of governing tariffs. 221.63... PROCEEDINGS) ECONOMIC REGULATIONS TARIFFS Governing Tariffs § 221.63 Other types of governing tariffs. Subject to approval of the Department, carriers may publish other types of governing tariffs not specified...

  11. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay...

  12. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay...

  13. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  14. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  15. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  16. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUNE 1, 2009) (a) Inspection by Government personnel. (1) Supplies to...

  17. 48 CFR 552.227-70 - Government Rights (Unlimited).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Government Rights....227-70 Government Rights (Unlimited). As prescribed in 527.409, insert the following clause: Government Rights (Unlimited) (MAY 1989) The Government shall have unlimited rights in all drawings,...

  18. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  19. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  20. 48 CFR 2945.105 - Records of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2945.105 Records of Government property. Contracting officers must maintain a file on any Government-furnished property (GFP) in the possession of contractors. As a...

  1. 48 CFR 1552.245-70 - Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government property. 1552... Government property. As prescribed in 1545.107(a), insert a clause substantially the same as follows: Government Property Government Property (a) The contractor shall not fabricate or acquire, on behalf of...

  2. 48 CFR 1952.227-76 - Government rights (unlimited).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government rights... 1952.227-76 Government rights (unlimited). As prescribed in 1927.405(g), insert the following clause: Government Rights (Unlimited) (FEB 1985) The Government shall have unlimited rights, in all drawings,...

  3. 48 CFR 1552.237-76 - Government-Contractor Relations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government-Contractor... 1552.237-76 Government-Contractor Relations. As prescribed in 1537.110(g), insert the following clause: Government-Contractor Relations (JUN 1999) (a) The Government and the Contractor understand and agree...

  4. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...

  5. 48 CFR 227.7103-5 - Government rights.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government rights. 227... 227.7103-5 Government rights. The standard license rights that a licensor grants to the Government are unlimited rights, government purpose rights, or limited rights. Those rights are defined in the clause...

  6. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  7. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  8. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  9. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  10. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  11. 48 CFR 2452.227-70 - Government information.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Government information... 2452.227-70 Government information. As prescribed in 2427.470, use the following clause: Government Information (DEC 2012) (a) Definitions. As used in this clause, “Government information” includes—...

  12. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  13. 48 CFR 227.7103-5 - Government rights.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government rights. 227... 227.7103-5 Government rights. The standard license rights that a licensor grants to the Government are unlimited rights, government purpose rights, or limited rights. Those rights are defined in the clause...

  14. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  15. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma (also known...

  16. 48 CFR 225.7402-3 - Government support.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government support. 225... States 225.7402-3 Government support. (a) Government support that may be authorized or required for... coordination with the combatant commander that— (1) Such Government support is available and is needed...

  17. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...

  18. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  19. 48 CFR 942.705-4 - State and local governments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... governments. 942.705-4 Section 942.705-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... governments. A list of cognizant agencies for State/local government organizations is periodically published... notified of such assignments. The current negotiated rates for State/local government activities...

  20. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...