Science.gov

Sample records for government regulation

  1. Regulating the New Governance

    ERIC Educational Resources Information Center

    Cope, Stephen; Goodship, Jo; Holloway, David

    2003-01-01

    This article arises out of a research project that sought to assess the development of regulation within the public sector. It examines the forms and impact of the regulatory systems that now operate within the public sector focusing on the further education sector. The research project developed out of an awareness that the increase in various…

  2. Regulating the New Governance

    ERIC Educational Resources Information Center

    Cope, Stephen; Goodship, Jo; Holloway, David

    2003-01-01

    This article arises out of a research project that sought to assess the development of regulation within the public sector. It examines the forms and impact of the regulatory systems that now operate within the public sector focusing on the further education sector. The research project developed out of an awareness that the increase in various…

  3. 31 CFR 352.1 - Governing regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES HH § 352.1 Governing regulations. Series HH bonds are subject to the regulations of the Department of the Treasury, now or hereafter prescribed, governing United States Savings Bonds of Series EE and HH...

  4. 31 CFR 316.3 - Governing regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... definitive Series E bonds that have been converted to book-entry bonds through New Treasury Direct. ..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT OFFERING OF UNITED STATES SAVINGS BONDS, SERIES E § 316.3 Governing regulations. (a) The regulations in 31 CFR part 315 apply to definitive Series E...

  5. Major Federal Regulations Governing Social Science Research.

    ERIC Educational Resources Information Center

    Gandara, Arturo

    This report provides administrators, project leaders, and researchers with information about major federal regulations governing research in the social sciences. The report is presented in five major chapters. Chapter I identifies the report's limitations. For example, it describes only statutory and regulatory provisions and covers only domestic…

  6. Major Federal Regulations Governing Social Science Research.

    ERIC Educational Resources Information Center

    Gandara, Arturo

    This report provides administrators, project leaders, and researchers with information about major federal regulations governing research in the social sciences. The report is presented in five major chapters. Chapter I identifies the report's limitations. For example, it describes only statutory and regulatory provisions and covers only domestic…

  7. 31 CFR 380.0 - What do these regulations govern?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What do these regulations govern? 380.0 Section 380.0 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued... VALUATION General Information § 380.0 What do these regulations govern? The regulations in this part govern...

  8. International Religion Indexes: Government Regulation, Government Favoritism, and Social Regulation of Religion*

    PubMed Central

    Grim, Brian J.; Finke, Roger

    2014-01-01

    The study of religion is severely handicapped by a lack of adequate cross-national data. Despite the prominence of religion in international events and recent theoretical models pointing to the consequences of regulating religion, cross-national research on religion has been lacking. We strive to fill this void by developing measurement models and indexes for government regulation, government favoritism, and social regulation of religion. The indexes rely on data from an extensive coding of the 2003 International Religious Freedom Report for 196 countries and territories. Using a series of tests to evaluate the new data and indexes, we find that the measures developed are highly reliable and valid. The three indexes will allow researchers and others to measure the government’s subsidy and regulation of religion as well as the restrictions placed on religion by social and cultural forces beyond the state. PMID:25484633

  9. 75 FR 79455 - OPEN GOVERNMENT AND EVIDENCE-BASED REGULATION

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... From the Federal Register Online via the Government Publishing Office ] OPEN GOVERNMENT AND EVIDENCE-BASED REGULATION There is a close connection, even an inextricable relationship, between open government and evidence- based regulation. If regulatory choices are based on careful analysis of the evidence, and if opportunities are provided for...

  10. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Regulation governing imports of walnuts. 999.100... SPECIALTY CROPS; IMPORT REGULATIONS § 999.100 Regulation governing imports of walnuts. (a) Definitions. (1) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2)...

  11. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Regulation governing imports of walnuts. 999.100... SPECIALTY CROPS; IMPORT REGULATIONS § 999.100 Regulation governing imports of walnuts. (a) Definitions. (1) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2)...

  12. 7 CFR 999.100 - Regulation governing imports of walnuts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Regulation governing imports of walnuts. 999.100... SPECIALTY CROPS; IMPORT REGULATIONS § 999.100 Regulation governing imports of walnuts. (a) Definitions. (1) Walnuts means all walnuts commonly known as English or Persian walnuts (Juglans regia). (2) Inshell...

  13. Government Regulations and the Use of Drugs

    PubMed Central

    Hafkenschiel, Joseph H.

    1967-01-01

    I have tried to trace the new drug development pattern from 1766, when Withering obtained his medical degree, to the present. The role of governmental authority as defined by the 1962 Kefauver-Harris amendments to the 1906 law and the subsequently issued regulations has been summarized. Four phases of testing in man have been detailed. Something of the scientific or research capability of the pharmaceutical industry has been presented. It is concluded that in the period of over two hundred years of medical education in the United States, the university hospital has become more and more the focus of medical research, teaching and practice in the community. The safety and effectiveness in the use of drugs in the future will depend upon the liaison and rapport of the industry physicians, government officials and the university hospital teacher-clinical investigators (phase 1 and 2) in designing the most critical studies of the safety and effectiveness of new drugs. Whether the medical profession as we know it will participate more in the future than has been possible since 1962 in mass clinical trial (phase 3) before new drug approval by governmental authority remains to be seen. The final approbation or disapproval of a drug after NDA approval (phase 4) will continue to be in the hands of the participating physician as long as he can establish scientifically that the drug is the best possible agent for him to use in healing the sick and comforting the dying. PMID:4862066

  14. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.200 Regulations governing navigable waters... of the Army to govern navigation and navigable waters, are contained in the Code of Federal... Army to prescribe such regulations for the use, administration, and navigation of the navigable waters...

  15. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.200 Regulations governing navigable waters... of the Army to govern navigation and navigable waters, are contained in the Code of Federal... Army to prescribe such regulations for the use, administration, and navigation of the navigable waters...

  16. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.200 Regulations governing navigable waters... of the Army to govern navigation and navigable waters, are contained in the Code of Federal... Army to prescribe such regulations for the use, administration, and navigation of the navigable waters...

  17. 78 FR 26518 - Federal Acquisition Regulation; Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 52 Federal Acquisition Regulation; Government Property CFR Correction In Title 48 of the Code of Federal Regulations...

  18. 76 FR 39788 - Regulations Governing Fees for Services

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... Surface Transportation Board 49 CFR Part 1002 Regulations Governing Fees for Services AGENCY: Surface Transportation Board. ACTION: Final rule. SUMMARY: The Board is amending the regulations governing user fees for services performed. The amendment sets the fee for certain formal complaints at $350. DATES: Effective...

  19. Church and Campus: Government Regulation of Religiously Affiliated Higher Education.

    ERIC Educational Resources Information Center

    Moots, Philip R.; Gaffney, Edward McGlynn, Jr.

    A study on government regulation of religiously affiliated higher education was conducted for the Sloan Commission on Government and Higher Education. The following two questions were addressed: What legal problems arising from governmental regulation have religiously affiliated colleges experienced at least partially because of their religious…

  20. 77 FR 75362 - Government in the Sunshine Act Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... From the Federal Register Online via the Government Publishing Office EQUAL EMPLOYMENT OPPORTUNITY COMMISSION 29 CFR Part 1612 Government in the Sunshine Act Regulations CFR Correction 0 In Title 29 of the Code of Federal Regulations, Parts 900 to 1899, revised as of July 1, 2012, on page 266, in Sec. 1612.6...

  1. Bureaucrats and Brainpower: Government Regulation of Universities.

    ERIC Educational Resources Information Center

    Seabury, Paul, Ed.

    The exploration of the growth and cost benefit effectiveness of governmental regulation of higher education is examined in this book. An introductory article by Robert Hatfield examines university regulation from a businessman's perspective. Hatfield concludes that business and higher education must work together to curb the stream of regulation.…

  2. Broadcasting and Government; Responsibilities and Regulations.

    ERIC Educational Resources Information Center

    Emery, Walter B.

    The role of governmental agencies in the control of wire and radio communication, especially broadcasting, is explained. A major portion of the book concerns the broadcast spectrum, its character and utility for communications, and the technical rules which govern the allocation of radio frequencies and their use by various classes of stations,…

  3. Broadcasting and Government; Responsibilities and Regulations.

    ERIC Educational Resources Information Center

    Emery, Walter B.

    The role of governmental agencies in the control of wire and radio communication, especially broadcasting, is explained. A major portion of the book concerns the broadcast spectrum, its character and utility for communications, and the technical rules which govern the allocation of radio frequencies and their use by various classes of stations,…

  4. TSCA Section 21 Petition to Promulgate Regulations Governing PVCs

    EPA Pesticide Factsheets

    This petition requests EPA to promulgate regulations governing the safe treatment, storage and disposal of polyvinyl chloride (PVC), vinyl chloride and associated dialkyl- and alkylarylesters of 1,2-benzenedicarboxylic acid.

  5. 76 FR 18072 - Federal Acquisition Regulation; Government Property Disposal; Forms

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE GENERAL SERVICES ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 48 CFR Part 53 Federal Acquisition Regulation; Government Property Disposal; Forms CFR Correction In Title 48 of the Code of Federal...

  6. Governing nanobiotechnology: lessons from agricultural biotechnology regulation

    NASA Astrophysics Data System (ADS)

    Johnson, Robbin S.

    2011-04-01

    This article uses lessons from biotechnology to help inform the design of oversight for nanobiotechnology. Those lessons suggest the following: first, oversight needs to be broadly defined, encompassing not just regulatory findings around safety and efficacy, but also public understanding and acceptance of the technology and its products. Second, the intensity of scrutiny and review should reflect not just risks but also perceptions of risk. Finally, a global marketplace argues for uniform standards or commercially practical solutions to differences in standards. One way of designing oversight to achieve these purposes is to think about it in three phases—precaution, prudence, and promotion. Precaution comes early in the technology or product's development and reflects real and perceived uncertainties. Prudence governs when risks and hazards have been identified, containment approaches established, and benefits broadly defined. Transparency and public participation rise to the fore. The promotional phase moves toward shaping public understanding and acceptance and involves marketing issues rather than safety ones. This flexible, three-phase approach to oversight would have avoided some of the early regulatory problems with agricultural biotechnology. It also would have led to a more risk-adjusted pathway to regulatory approval. Furthermore, it would avoid some of the arbitrary, disruptive marketing issues that have arisen.

  7. SIGNALS AND REGULATORS THAT GOVERN STREPTOMYCES DEVELOPMENT

    PubMed Central

    McCormick, Joseph R.; Flärdh, Klas

    2012-01-01

    Streptomyces coelicolor is the genetically best characterized species of a populous genus belonging to the Gram-positive Actinobacteria. Streptomycetes are filamentous soil organisms, well known for the production of a plethora of biologically active secondary metabolic compounds. The Streptomyces developmental life cycle is uniquely complex, and involves coordinated multicellular development with both physiological and morphological differentiation of several cell types, culminating in production of secondary metabolites and dispersal of mature spores. This review presents a current appreciation of the signaling mechanisms used to orchestrate the decision to undergo morphological differentiation, and the regulators and regulatory networks that direct the intriguing development of multigenomic hyphae, first to form specialized aerial hyphae, and then to convert them into chains of dormant spores. This current view of S. coelicolor development is destined for rapid evolution as data from “-omics” studies shed light on gene regulatory networks, new genetic screens identify hitherto unknown players, and the resolution of our insights into the underlying cell biological processes steadily improve. PMID:22092088

  8. 76 FR 6003 - Defense Federal Acquisition Regulation Supplement; Marking of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... 252 Defense Federal Acquisition Regulation Supplements; Marking of Government-Furnished Property... Regulation Supplement; Marking of Government-Furnished Property AGENCY: Defense Acquisition Regulations... the Defense Federal Acquisition Regulation Supplement (DFARS) to require contractors to tag, label, or...

  9. Government policy and fertility regulation: unintended consequences and perverse effects.

    PubMed

    Faria, V E

    1997-01-01

    Since some argue that the recent and marked fertility decline experienced in Brazil is related to institutional changes resulting from public policies promoted by the federal government since 1964, the author attempts to shed light upon the role played by such policies upon fertility regulation. Fertility in Brazil and the main explanatory theories are first discussed. The paper then considers the role played by the growth of the consumer society, social security coverage, mass media, and the medicalization of society upon changing patterns of fertility regulation in Brazil. The discussion of government policies and fertility regulation includes consideration of consumer credit policy, social security benefit policy, telecommunications policy, and health care policy. One salient conclusion of the analysis is that the lack of a policy to provide fertility regulation mechanisms other than through the marketplace hurts relatively poor populations.

  10. The role of government and regulation in cancer prevention.

    PubMed

    Brawley, Otis W

    2017-08-01

    The world population is ageing and increasing in size. As a result, the numbers of people diagnosed with and dying of cancer are increasing. Cancer is also a growing problem in developing countries. Government, be it local, state, provincial, national, or even a union of nations, has clear roles in the control of cancer. It is widely appreciated that much of the research that has defined the causes and treatment of cancer was, and is, government funded. Less appreciated, the body of work about how to control cancer shows the importance of an environment that encourages individuals to adopt healthy behaviours, and government has a vitally important role. Through regulation, education, and support programmes, governments can create an environment in which tobacco use is reduced and citizens maintain good levels of physical activity, healthy bodyweight, and good nutrition. Cancer prevention and the creation of a culture of health is an essential mission of government, beyond that of the traditional health-focused departments such as health ministries; it is in the domain of governmental agencies involved in environmental protection, occupational safety, and transportation. Cancer prevention and health promotion are also in the realm of the zoning board, the board of education, and the board of health. Copyright © 2017 Elsevier Ltd. All rights reserved.

  11. Government regulation of sex and sexuality: in their own words.

    PubMed

    Gruskin, Sofia; Ferguson, Laura

    2009-11-01

    Criminalisation is but one of the tools employed by governments to regulate sex and sexuality. Other types of regulation can equally have an impact on health and well-being and thus merit consideration. While restrictive laws related to sexuality are often driven by moral argumentation, public health evidence and human rights norms highlight the need for supportive legal and policy environments. International legal commitments can serve as a check against national laws and policies which do not conform to international consensus. Reporting mechanisms which draw attention to affected populations in the context of HIV have provided a lens through which governments can begin to see the harms to health and well-being caused by their own regulation of sexuality. A review of 2008 self-reported legal and policy data from the 133 countries reporting under the Declaration of Commitment on HIV/AIDS offers important insights. International and national legal and policy environments relating to sexuality are evolving. By identifying dissonance between international standards and national laws and policies, a refocusing of efforts is possible, aiding governments to meet their international obligations and ensuring an appropriate environment for the free and safe expression of sexuality.

  12. Government regulation to promote healthy food environments--a view from inside state governments.

    PubMed

    Shill, J; Mavoa, H; Allender, S; Lawrence, M; Sacks, G; Peeters, A; Crammond, B; Swinburn, B

    2012-02-01

    Food policy interventions are an important component of obesity-prevention strategies and can potentially drive positive changes in obesogenic environments. This study sought to identify regulatory interventions targeting the food environment, and barriers/facilitators to their implementation at the Australian state government level. In-depth interviews were conducted with senior representatives from state/territory governments, statutory authorities and non-government organizations (n =45) to examine participants' (i) suggestions for regulatory interventions for healthier food environments and (ii) support for pre-selected regulatory interventions derived from a literature review. Data were analysed using thematic and constant comparative analyses. Interventions commonly suggested by participants were regulating unhealthy food marketing; limiting the density of fast food outlets; pricing reforms to decrease fruit/vegetable prices and increase unhealthy food prices; and improved food labelling. The most commonly supported pre-selected interventions were related to food marketing and service. Primary production and retail sector interventions were least supported. The dominant themes were the need for whole-of-government and collaborative approaches; the influence of the food industry; conflicting policies/agenda; regulatory challenges; the need for evidence of effectiveness; and economic disincentives. While interventions such as public sector healthy food service policies were supported by participants, marketing restrictions and fiscal interventions face substantial barriers including a push for deregulation and private sector opposition. © 2011 The Authors. obesity reviews © 2011 International Association for the Study of Obesity.

  13. Should states and local governments regulate dietary supplements?

    PubMed

    Starr, Ranjani

    2016-01-01

    Federal regulation of dietary supplements in the United States is governed by the Dietary Supplement Health and Education Act of 1994. The law has been criticized as weak and ineffective. Alarming research has emerged demonstrating that supplements may be mislabelled, contaminated, adulterated with dangerous or unknown compounds, or sold at toxic doses. As a result, the health community has raised concerns about the safety and quality of dietary supplements. Increased federal oversight is an important avenue for improving supplement safety; however, states and local governments may also pursue strategies to strengthen the overall regulatory control of dietary supplements. States and local governments have substantial experience in regulating other products that pose a risk to public health, such as tobacco. Additionally, much has been learned about the tactics the tobacco industry has employed to protect its interests. Lessons learned may be applied to new regulatory efforts aimed at improving the safety of dietary supplements at the state and local levels. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  14. Understanding Philip Morris's pursuit of US government regulation of tobacco

    PubMed Central

    McDaniel, P; Malone, R

    2005-01-01

    Objective: To investigate Philip Morris's support of US Food and Drug Administration (FDA) regulation of tobacco products and analyse its relationship to the company's image enhancement strategies. Data sources: Internal Philip Morris documents released as part of the Master Settlement Agreement. Methods: Searches of the Legacy Tobacco Documents Library (http://legacy.library.ucsf.edu) beginning with such terms as "FDA" and "regulatory strategy" and expanding to include relevant new terms. Results: Philip Morris's support for government regulation of tobacco is part of a broader effort to address its negative public image, which has a damaging impact on the company's stock price, political influence, and employee morale. Through regulation, the company seeks to enhance its legitimacy, redefine itself as socially responsible, and alter the litigation environment. Whereas health advocates frame tobacco use as a public health policy issue, Philip Morris's regulatory efforts focus on framing tobacco use as an individual choice by informed adults to use a risky product. This framing allows Philip Morris to portray itself as a reasonable and responsible manufacturer and marketer of risky products. Conclusions: Philip Morris's ability to improve its image through support of FDA regulation may undermine tobacco control efforts aimed at delegitimising the tobacco industry. It may also create the impression that Philip Morris's products are being made safer and ultimately protect the company from litigation. While strong regulation of tobacco products and promotion remain critical public health goals, previous experiences with tobacco regulation show that caution may be warranted. PMID:15923470

  15. Effect of Government Regulation on the Evolution of Sports Nutrition

    NASA Astrophysics Data System (ADS)

    Collins, Rick; Kalman, Douglas

    The sports nutrition segment of the dietary supplement industry enjoyed nearly a decade of unfettered growth under federal legislation passed in 1994. A series of breakthroughs in the dietary supplement field led to the development and marketing of innovative products designed to enhance performance, build muscle, or lose excess fat. As the popularity of these products soared and evolved into a multi-billion dollar industry, the sports nutrition supplement market drew the attention of federal and state regulatory bodies and sports antidoping authorities. Growing concerns over potential health risks and unfair athletic advantages have spurred government regulators and legislators to heighten the scrutiny of this market, leading to recent legislative amendments and increased government enforcement action.

  16. Impact of government regulation on health care technology

    NASA Astrophysics Data System (ADS)

    Berkowitz, Robert D.

    1994-12-01

    Increased government regulation of the medical device industry produces higher expenses, a longer time to return investment capital, and greater uncertainty. As a result there are fewer new ventures and reduced efforts to develop new technology in established companies. The current federal regulatory framework has shifted from monitoring the product to monitoring the process. The inability to reach perfect performance in such a regulated environment subject to continuous and fluid interpretation guarantees non-compliance and growing ethical tension. Without new medical technology, we may be unable to maintain quality medical coverage in the face of rising demand. The author proposes risk assessment to set regulatory priorities; the conversion of a national weapons lab to a national device testing lab; the establishment of device standards and the monitoring of in-use performance against these standards; and the education of patients and users as to the results of these examinations.

  17. 34 CFR 655.1 - Which programs do these regulations govern?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Which programs do these regulations govern? 655.1... § 655.1 Which programs do these regulations govern? The regulations in this part govern the... International Research and Studies Program (section 605); and (e) The Business and International Education...

  18. Controversy over genetically modified organisms: the governing laws and regulations.

    PubMed

    Keatley, K L

    2000-01-01

    Genetically Modified Organisms (GMOs) are increasingly becoming a topic of controversy in the U.S. and abroad. The public is questioning their safety and wanting the products labeled as genetically modified. There are other concerns from some of the scientific world and some government officials and organizations such as the Food & Agricultural Organization (FAO) that question whether adequate research has been done to qualify GMOs as safe for long-term use. Of particular concern are the allergenic properties, a GMO may impart, possible transfer effects of antibiotic resistance (given that antibiotic resistant marker genes are used for many GMOs), the expression of previously unexpressed traits, and the drift of pollen from genetically modified crops. It has also been noted that the laws and regulations governing the biotechnology world are outdated, are not comprehensive, and span too many agencies. The primary agencies currently regulating biotechnology are the U.S. Department of Agriculture (USDA), the Food and Drug Administration (FDA), and the Environmental Protection Agency (EPA).

  19. Pharmaceuticals in Australia: developments in regulation and governance.

    PubMed

    Lofgren, Hans; Boer, Rebecca de

    2004-06-01

    The pharmaceutical domain represents a type of internationalised policy network theorised in recent writings on neo-liberalism, neo-corporatism and governance. This article presents an analysis of developments in prescription drug regulation in Australia. A relatively stable, state-managed pattern of interaction has been superseded by less closed exchange, and the government itself has fragmented into agencies pursuing different objectives. Developments in the three core regulatory areas are described: safety and efficacy controls, social policy (access and equity), and state support for industry (economic) development. Consensus-building occurs within the context of the National Medicines Policy. The pharmaceutical industry, represented by Medicines Australia, has a stake in all aspects of pharmaceutical policy and regulation, and draws upon unique resources (expertise and lobbying capacity). The context for the developments described is Australia's abandonment of a protectionist version of the Keynesian welfare national state in favour of the model of the competition state, which is oriented towards support for the growth of high technology industries such as pharmaceuticals, premised on partnerships with business.

  20. 49 CFR Appendix E to Part 99 - Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Statutes Regulating Post-Employment Responsibilities of Government and Special Government Employees E Appendix E to Part 99 Transportation Office of the Secretary of Transportation EMPLOYEE RESPONSIBILITIES AND CONDUCT Pt. 99, App. E Appendix E...

  1. Performance Government: Activating and Regulating the Self-Governing Capacities of Teachers and School Leaders

    ERIC Educational Resources Information Center

    O'Brien, Peter C.

    2015-01-01

    This article analyses "performance government" as an emergent form of rule in advanced liberal democracies. It discloses how teachers and school leaders in Australia are being governed by the practices of performance government which centre on the recently established Australian Institute for Teaching and School Leadership (AITSL) and…

  2. Performance Government: Activating and Regulating the Self-Governing Capacities of Teachers and School Leaders

    ERIC Educational Resources Information Center

    O'Brien, Peter C.

    2015-01-01

    This article analyses "performance government" as an emergent form of rule in advanced liberal democracies. It discloses how teachers and school leaders in Australia are being governed by the practices of performance government which centre on the recently established Australian Institute for Teaching and School Leadership (AITSL) and…

  3. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false What regulations govern Series EE... SAVINGS BONDS, SERIES EE General Information § 351.1 What regulations govern Series EE savings bonds? (a) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have...

  4. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false What regulations govern Series I... SAVINGS BONDS, SERIES I General Information § 359.1 What regulations govern Series I savings bonds? (a) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have...

  5. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false What regulations govern Series EE... SAVINGS BONDS, SERIES EE General Information § 351.1 What regulations govern Series EE savings bonds? (a) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have...

  6. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false What regulations govern Series I... SAVINGS BONDS, SERIES I General Information § 359.1 What regulations govern Series I savings bonds? (a) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have...

  7. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false What regulations govern Series I... SAVINGS BONDS, SERIES I General Information § 359.1 What regulations govern Series I savings bonds? (a) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have...

  8. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What regulations govern Series I... SAVINGS BONDS, SERIES I General Information § 359.1 What regulations govern Series I savings bonds? (a) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have...

  9. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false What regulations govern Series EE... SAVINGS BONDS, SERIES EE General Information § 351.1 What regulations govern Series EE savings bonds? (a) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have...

  10. 31 CFR 359.1 - What regulations govern Series I savings bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false What regulations govern Series I... SAVINGS BONDS, SERIES I General Information § 359.1 What regulations govern Series I savings bonds? (a) The regulations in 31 CFR part 360 apply to definitive (paper) Series I savings bonds that have...

  11. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What regulations govern Series EE... SAVINGS BONDS, SERIES EE General Information § 351.1 What regulations govern Series EE savings bonds? (a) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have...

  12. 31 CFR 351.1 - What regulations govern Series EE savings bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false What regulations govern Series EE... SAVINGS BONDS, SERIES EE General Information § 351.1 What regulations govern Series EE savings bonds? (a) The regulations in 31 CFR part 353 apply to definitive (paper) Series EE savings bonds that have...

  13. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false What regulations apply to self-governance Tribes? 1000... INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  14. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 2 2014-04-01 2014-04-01 false What regulations apply to self-governance Tribes? 1000... INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  15. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What regulations apply to self-governance Tribes? 1000... INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  16. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 2 2013-04-01 2013-04-01 false What regulations apply to self-governance Tribes? 1000... INTERIOR ANNUAL FUNDING AGREEMENTS UNDER THE TRIBAL SELF-GOVERNMENT ACT AMENDMENTS TO THE INDIAN SELF-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  17. Ethical regulation or regulating ethics? The need for both internal and external governance of human experimentation.

    PubMed

    Tomossy, George F

    2002-10-01

    Research regulation is a timely topic for discussions in bioethics and public health policy. This response to articles in the previous special issue of the Monash Bioethics Review emphasises the importance of having both internal and external controls on human experimentation. Unless both elements are incorporated into research ethics governance frameworks, they will ultimately fail to achieve what should be their primary goal: human subject protection.

  18. 75 FR 38675 - Federal Acquisition Regulation; FAR Case 2008-011, Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ...The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) have agreed on a final rule amending the Federal Acquisition Regulation (FAR) to revise FAR part 45, Government Property, and its associated...

  19. 76 FR 12666 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property AGENCY: Defense Acquisition.... SUMMARY: DoD is proposing to amend the Defense Federal Acquisition Regulation Supplement (DFARS) to revise...

  20. 76 FR 9527 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... Regulation Supplement; Reporting of Government-Furnished Property (DFARS Case 2009-D043) AGENCY: Defense... period. SUMMARY: DoD is proposing to amend the Defense Federal Acquisition Regulation Supplement (DFARS...

  1. 76 FR 11190 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property (DFARS Case 2009-D043) AGENCY... proposed rule. SUMMARY: DoD is proposing to amend the Defense Federal Acquisition Regulation Supplement...

  2. 76 FR 11985 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... Acquisition Regulation Supplement; Reporting of Government-Furnished Property AGENCY: Defense Acquisition...: DoD is proposing to amend the Defense Federal Acquisition Regulation Supplement (DFARS) to revise and...

  3. 76 FR 12315 - Committees on Collaborative Governance, Regulation, Rulemaking, Judicial Review, and Adjudication

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ...; ] ADMINISTRATIVE CONFERENCE OF THE UNITED STATES Committees on Collaborative Governance, Regulation, Rulemaking... 20036; Telephone 202-480-2080. SUPPLEMENTARY INFORMATION: Committee on Collaborative Governance The Committee on Collaborative Governance will meet to consider a report by Professor James T. O'Reilly of...

  4. Dimensions of Environmental Management: Legitimation of Government Regulation by Industrial Managers

    ERIC Educational Resources Information Center

    Rickson, Roy E.

    1977-01-01

    Examines the environmental management issue of government regulation of water use and waste processes. Discusses problems of establishing authority in the interorganizational network of industry-government relationships. Research data are presented from a three-year study of industry-government relationships and pollution abatement change by…

  5. 75 FR 33796 - Federal Acquisition Regulation; Submission for OMB Review; Government Property; OMB Control No...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE... Regulation; Submission for OMB Review; Government Property; OMB Control No. 9000-0075 AGENCIES: Department of... Government Property. A notice was published in the Federal Register at 75 FR 17410, on April 6, 2010. No...

  6. Dimensions of Environmental Management: Legitimation of Government Regulation by Industrial Managers

    ERIC Educational Resources Information Center

    Rickson, Roy E.

    1977-01-01

    Examines the environmental management issue of government regulation of water use and waste processes. Discusses problems of establishing authority in the interorganizational network of industry-government relationships. Research data are presented from a three-year study of industry-government relationships and pollution abatement change by…

  7. 77 FR 24611 - Removal of Regulations Requiring 3% Withholding by Government Entities

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... affects government entities that would have been required to withhold and report tax from payments to... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY... Government Entities AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Final regulations....

  8. 75 FR 29917 - Migratory Bird Permits; Changes in the Regulations Governing Migratory Bird Rehabilitation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... Fish and Wildlife Service 50 CFR Part 21 RIN 1018-AX09 Migratory Bird Permits; Changes in the Regulations Governing Migratory Bird Rehabilitation AGENCY: Fish and Wildlife Service, Interior. ACTION: Final... on October 27, 2003, to create regulations governing migratory bird rehabilitation in the United...

  9. Government Legislation and Regulations in the United States

    EPA Science Inventory

    For centuries, customary or traditional laws have covered the use of biological resources throughout the world. As human population levels increase in all societies, voluntary actions governed by cultural practices are frequently insufficient to protect biodiversity, leading to...

  10. Government Legislation and Regulations in the United States

    EPA Science Inventory

    For centuries, customary or traditional laws have covered the use of biological resources throughout the world. As human population levels increase in all societies, voluntary actions governed by cultural practices are frequently insufficient to protect biodiversity, leading to...

  11. 7 CFR 61.5 - Regulations to govern.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) COTTONSEED SOLD OR OFFERED...

  12. Laws and Regulations Governing Teacher Education and Certification.

    ERIC Educational Resources Information Center

    Hailey, Paul W.

    This document covers 1) sections of Ohio law governing teacher education and certification, types of certificates, standards for certification, and renewal and revocation of certificates; 2) definitions and general information; 3) administrative and supervisory certificates; 4) elementary and kindergarten-primary teaching certificates; 5) high…

  13. 77 FR 74382 - Acquisition Regulation: Department of Energy Acquisition Regulation, Government Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... supplemental to and explicitly reaffirms the principles, structures, and definitions governing regulatory... Government, and nuclear and special source materials, atomic weapons, and by-product materials. Sensitive...

  14. 25 CFR 1000.220 - What regulations apply to self-governance Tribes?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What regulations apply to self-governance Tribes? 1000.220 Section 1000.220 Indians OFFICE OF THE ASSISTANT SECRETARY, INDIAN AFFAIRS, DEPARTMENT OF THE...-DETERMINATION AND EDUCATION ACT Waiver of Regulations § 1000.220 What regulations apply to...

  15. State Laws and Regulations Governing Teachers Certificates. Bulletin, 1921, No. 22

    ERIC Educational Resources Information Center

    Cook, Katherine M.

    1921-01-01

    This study is intended to present information as complete as possible concerning the laws and regulations which govern the issue of teachers' certificates in the United States in so far as they are regulated by State legislation or State administrative departments. Licenses to teach issued by city boards in accordance with regulations prescribed…

  16. Government Regulation of the Pursuit of Knowledge: The Recombinant DNA Controversy.

    ERIC Educational Resources Information Center

    Berger, Richard G.

    1978-01-01

    Government regulation of recombinant DNA research is addressed. Issues discussed include the potential of such research; National Institutes of Health guidelines; federal, state, and local regulation; the controversy over self-regulation; first amendment protection for scientific research; and problems in drafting legislation. (JMD)

  17. Government Regulation of the Pursuit of Knowledge: The Recombinant DNA Controversy.

    ERIC Educational Resources Information Center

    Berger, Richard G.

    1978-01-01

    Government regulation of recombinant DNA research is addressed. Issues discussed include the potential of such research; National Institutes of Health guidelines; federal, state, and local regulation; the controversy over self-regulation; first amendment protection for scientific research; and problems in drafting legislation. (JMD)

  18. 75 FR 71397 - Regulations Establishing and Governing the Duties of Swap Dealers and Major Swap Participants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... From the Federal Register Online via the Government Publishing Office COMMODITY FUTURES TRADING... Major Swap Participants AGENCY: Commodity Futures Trading Commission. ACTION: Notice of proposed rulemaking. SUMMARY: The Commodity Futures Trading Commission is proposing regulations to implement...

  19. 76 FR 71823 - Defense Federal Acquisition Regulation Supplement: Responsibility and Liability for Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Regulation Supplement: Responsibility and Liability for Government Property (DFARS Case 2010-D018) AGENCY... responsibility for all costs and resulting profit and loss. The FAR already provides that contractors are not... Government property is not universal. There are many examples of contractors retaining responsibility...

  20. 75 FR 2126 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre-Filing Workshop January 5, 2010. On January 12,...

  1. 75 FR 3395 - Migratory Bird Permits; Changes in the Regulations Governing Falconry

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF THE INTERIOR Fish and Wildlife Service 50 CFR Parts 21 and 22 RIN 1018-AW44 Migratory Bird Permits; Changes in the Regulations Governing Falconry Correction In rule document 2010-12 beginning on page 927 in the issue of...

  2. How State and Local Governments Regulate Economic Activities: A Consumer Briefing.

    ERIC Educational Resources Information Center

    Nelson, Helen E.

    This paper depicts some of the ways State and local governments define, regulate, and police the communities and markets where consumers convert their income into a way of life. Explained are how regulatory processes are developed in State and local government, what the underlying concepts are, and some of the access points for fruitful citizen…

  3. 75 FR 40754 - Government in the Sunshine Act Regulations of the National Science Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-14

    ... From the Federal Register Online via the Government Publishing Office NATIONAL SCIENCE FOUNDATION 45 CFR Part 614 RIN 3145-AA53 Government in the Sunshine Act Regulations of the National Science Board AGENCY: National Science Board (NSB), National Science Foundation (NSF). ACTION: Direct final...

  4. Governing childhood obesity: framing regulation of fast food advertising in the Australian print media.

    PubMed

    Henderson, Julie; Coveney, John; Ward, Paul; Taylor, Anne

    2009-11-01

    Childhood obesity is widely constructed as reaching epidemic proportions with consumption of fast food viewed as a contributing factor. This paper analyses media reporting of the regulation of fast food consumption to children. A media search of five Australian newspapers for the period January 2006 to June 2008 elicited 100 articles relating to the regulation of fast food advertising to children. Content and thematic analysis of the articles reveal conflicting perspectives on the role of the state; the level of accountability of the food and advertising industries; and responsibilities of parents for regulating fast food consumption in children. The Federal Government, food and advertising industries and free to air broadcasters favour industry self-regulation and personal responsibility for fast food consumption while the proponents of government regulation include consumer groups, state government health ministers, nutrition and public health academics and medical and health foundations. The regulation of fast food advertising to children is discussed in relation to ideas about governance and the public health strategies which follow from these ideas. The paper argues that all proposed solutions are indicative of a neoliberal approach to the governance of health insofar as the responsibility for regulation of food marketing is viewed as lying with industry and the regulation of lifestyle risk is viewed as an individual responsibility.

  5. Cell fate regulation governed by a repurposed bacterial histidine kinase

    SciTech Connect

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; Mathews, Irimpan I.; Blair, Jimmy A.; Deacon, Ashley M.; Shapiro, Lucy; Stock, Ann M.

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.

  6. 7 CFR 999.300 - Regulation governing importation of raisins.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE... Fruit and Vegetable Division of the Agricultural Marketing Service, U.S. Department of Agriculture... with applicable food and sanitary regulations of city, county, State, or Federal agencies. (h...

  7. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... waters. 209.200 Section 209.200 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE... Regulations, title 33, Navigation and Navigable Waters, Chapter II. (2) District engineers (or division engineers if considered preferable by the latter to avoid duplication in cases where the...

  8. 33 CFR 209.200 - Regulations governing navigable waters.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waters. 209.200 Section 209.200 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE... Regulations, title 33, Navigation and Navigable Waters, Chapter II. (2) District engineers (or division engineers if considered preferable by the latter to avoid duplication in cases where the...

  9. Cell fate regulation governed by a repurposed bacterial histidine kinase

    DOE PAGES

    Childers, W. Seth; Xu, Qingping; Mann, Thomas H.; ...

    2014-10-28

    One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interactionmore » between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.« less

  10. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  11. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  12. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  13. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When a child's disability determination is governed by the regulations of the Social Security...

  14. Federal government regulation of occupational skin exposure in the USA.

    PubMed

    Boeniger, Mark F; Ahlers, Heinz W

    2003-06-01

    There are at least 14 federal regulations and three agencies that are involved in the regulation of occupational skin exposures in the USA. The Environmental Protection Agency (EPA) requires the reporting of health effects information on chemicals, and such information is used to assess the risks of human and environmental exposure. The health effects information and any resulting risk assessments are generally available to the public. A fair amount of this information relates to skin irritation, sensitization, and dermal absorption. The EPA can require the submission of new data necessary for it to carry out its risk assessments, and has the authority to ban hazardous chemicals for certain uses. The Food and Drug Administration (FDA) regulates the correct labeling of cosmetics and requires safety and efficacy data on new products that are claimed to have preventive or health benefits. Commercial distribution of topical skin-care and protection products, therefore, can be potentially scrutinized by the FDA, which can control the use of hazardous chemicals in such products. The Occupational Safety and Health Administration (OSHA) has the most direct contact with workplaces through its field inspection compliance activity, which is directed at the reduction of workplace injuries and illnesses. Our analysis suggests that although considerable amounts of health effects information is generated and available, such information may not always be adequately conveyed to the end users of chemical products. In addition, the most effective and practical means of preventing exposure is often not apparent or generally known. Current regulations may have created a reliance on use of chemical protective equipment that may not always be the best approach to protecting workers. Lack of performance criteria that are measurable has hampered industry from objectively assessing skin exposures. This lack of performance criteria or guidance has also hindered the implementation of

  15. Regulations and guidelines governing stem cell based products: Clinical considerations

    PubMed Central

    George, Bobby

    2011-01-01

    The use of stem cells as medicines is a promising and upcoming area of research as they may be able to help the body to regenerate damaged or lost tissue in a host of diseases like Parkinson′s, multiple sclerosis, heart disease, liver disease, spinal cord damage, cancer and many more. Translating basic stem cell research into routine therapies is a complex multi-step process which entails the challenge related to managing the expected therapeutic benefits with the potential risks while complying with the existing regulations and guidelines. While in the United States (US) and European Union (EU) regulations are in place, in India, we do not have a well-defined regulatory framework for “stem cell based products (SCBP)”. There are several areas that need to be addressed as it is quite different from that of pharmaceuticals. These range from establishing batch consistency, product stability to product safety and efficacy through pre-clinical, clinical studies and marketing authorization. This review summarizes the existing regulations/guidelines in US, EU, India, and the associated challenges in developing SCBP with emphasis on clinical aspects. PMID:21897884

  16. Improving government regulations: a guidebook for conservation and renewable energy

    SciTech Connect

    Neese, R. J.; Scheer, R. M.; Marasco, A. L.

    1981-04-01

    An integrated view of the Office of Conservation and Solar Energy (CS) policy making encompassing both administrative procedures and policy analysis is presented. Chapter One very briefly sketches each step in the development of a significant regulation, noting important requirements and participants. Chapter Two expands upon the Overview, providing the details of the process, the rationale and source of requirements, concurrence procedures, and advice on the timing and synchronization of steps. Chapter Three explains the types of analysis documents that may be required for a program. Regulatory Analyses, Environmental Impact Statements, Urban and Community Impact Analyses, and Regulatory Flexibility Analyses are all discussed. Specific information to be included in the documents and the circumstances under which the documents need to be prepared are explained. Chapter Four is a step-by-step discussion of how to do good analysis. Use of models and data bases is discussed. Policy objectives, alternatives, and decision making are explained. In Chapter five guidance is provided on identifying the public that would most likely be interested in the regulation, involving its constituents in a dialogue with CS, evaluating and handling comments, and engineering the final response. Chapter Six provides direction on planning the evaluation, monitoring the regulation's success once it has been promulgated, and allowing for constructive support or criticism from outside DOE. (MCW)

  17. [Regulating factors of intention and experience with co-production related to local government administration].

    PubMed

    Takahashi, Naoya

    2008-12-01

    This study examined the regulating factors of intention and experience with co-production related to local government administration. The result of a survey for 211 adults showed that their intention to participate in co-production was determined by "contact/information disclosure expectations" for local government employees, dissatisfaction with local government, communication with the neighborhood, and the number of organizational affiliations in the community. Of these factors, the number of organizational affiliations also determined experiences with co-production. Co-production was promoted by increased affiliative expectations for local government employees and ties in the community for action.

  18. Governance.

    ERIC Educational Resources Information Center

    Moran, K. D.

    The author notes that two trends appear to be developing in litigation over the governance of the public schools. One trend is increasing participation of organized groups in suits against the schools. The other is a greater volume of litigation dealing with open meeting laws and freedom of information acts. Reflecting the second trend, the…

  19. Governance.

    ERIC Educational Resources Information Center

    Moran, K. D.

    This chapter summarized and analyzes all state supreme court and federal court decisions as well as other significant court decisions affecting the realm of school governance. The cases discussed are generally limited to those decided during 1974 and reported in the General Digest on or before March 1, 1975. Because of its unusual significance,…

  20. Regulations Governing The Certification Of Educational Personnel. State of Vermont. Including Revisions, July 1979.

    ERIC Educational Resources Information Center

    Vermont State Dept. of Education, Montpelier.

    The revised (1979) regulations governing the certification of educational personnel in the state of Vermont are presented. Part I contains general information on statutory changes, April 1, 1971; transition from 1965 to 1979 regulations; and how to apply for a certificate. Included also is information on program approval for teacher education and…

  1. Rules and Regulations Governing Teacher Certification in the Wyoming Public Schools, l983.

    ERIC Educational Resources Information Center

    Wyoming State Dept. of Education, Cheyenne.

    Rules and regulations governing teacher certification in the Wyoming Public Schools are outlined. Information is given on: (1) definition of terms; (2) general certification regulations; (3) application requirements; (4) denial, suspension, or revocation; (5) types of certification and permits; (6) standard teaching certification in general and…

  2. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false What types of geothermal operations are... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.10 What types of geothermal operations are governed by these utilization regulations? (a) The regulations...

  3. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false What types of geothermal operations are... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.10 What types of geothermal operations are governed by these utilization regulations? (a) The regulations...

  4. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false What types of geothermal operations are... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.10 What types of geothermal operations are governed by these utilization regulations? (a) The regulations...

  5. 43 CFR 3270.10 - What types of geothermal operations are governed by these utilization regulations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false What types of geothermal operations are... MANAGEMENT (3000) GEOTHERMAL RESOURCE LEASING Utilization of Geothermal Resources-General § 3270.10 What types of geothermal operations are governed by these utilization regulations? (a) The regulations...

  6. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Contained in Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans... Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans Affairs... regulations affecting financial assistance administered by the agency. This appendix is VA's list of age...

  7. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Contained in Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans... Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans Affairs... regulations affecting financial assistance administered by the agency. This appendix is VA's list of age...

  8. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Contained in Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans... Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans Affairs... regulations affecting financial assistance administered by the agency. This appendix is VA's list of age...

  9. 38 CFR Appendix B to Subpart E of... - List of Age Distinctions Contained in Statutes and Regulations Governing Federal Financial...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Contained in Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans... Statutes and Regulations Governing Federal Financial Assistance of the Department of Veterans Affairs... regulations affecting financial assistance administered by the agency. This appendix is VA's list of age...

  10. Analyzing Government Regulation: A Resource Guide. Economics-Political Science Series.

    ERIC Educational Resources Information Center

    Bibby, John F.; And Others

    Part of a series which offers educational resources and teaching techniques related to major social issues to high school social studies classroom teachers, the guide focuses on government regulation. The document is presented in four major chapters. Chapter I explores how economic and political science frameworks can be used to analyze policy…

  11. 75 FR 8329 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Rescheduled Alaska Natural Gas Transportation Projects Open Season Pre-Filing... for an Alaska Natural Gas Transportation Project. The Workshop is being held at the Commission's...

  12. Analysis of environmental regulations governing the disposal of geothermal wastes in California

    SciTech Connect

    Royce, B.A.

    1985-09-01

    Federal and California regulations governing the disposal of sludges and liquid wastes associated with the production of electricity from geothermal resources were evaluated. Current disposal practices, near/far term disposal requirements, and the potential for alternate disposal methods or beneficial uses for these materials were determined. 36 refs., 3 figs., 15 tabs. (ACR)

  13. Competition and Control: The Impact of Government Regulation on Teaching and Learning in English Schools

    ERIC Educational Resources Information Center

    Elkins, Tom; Elliott, John

    2004-01-01

    This paper outlines the ways in which successive UK governments have regulated and controlled the teaching profession since the 1980s. Key initiatives relating to curriculum, school effectiveness and individual teacher performance are considered in some detail, because these issues have arguably had the greatest impact upon teaching and learning.…

  14. 75 FR 6370 - Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Energy Regulatory Commission Regulations Governing the Conduct of Open Seasons for Alaska Natural Gas Transportation Projects; Notice of Alaska Natural Gas Transportation Projects Open Season Pre-Filing Workshop... hold a workshop on the procedures and process for holding and commenting on an open season for...

  15. 78 FR 72878 - Revisions to Procedural Regulations Governing Filing, Indexing and Service by Oil Pipelines...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-04

    ... Energy Regulatory Commission Revisions to Procedural Regulations Governing Filing, Indexing and Service... the filing, indexing and service procedures used by oil pipelines.\\1\\ Take notice that, effective...: \\2\\ \\1\\ Filing, Indexing and Service Requirements for Oil Pipelines, 143 FERC ] 61,137 (2013) (Order...

  16. 34 CFR 400.2 - What programs are governed by these regulations?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Vocational Institutions Program (34 CFR part 410). (7) Vocational Education Research Program (34 CFR part 411... 412). (9) National Center or Centers for Research in Vocational Education (34 CFR part 413). (10... 34 Education 3 2011-07-01 2011-07-01 false What programs are governed by these regulations? 400.2...

  17. 50 CFR 18.27 - Regulations governing small takes of marine mammals incidental to specified activities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... marine mammals incidental to specified activities. 18.27 Section 18.27 Wildlife and Fisheries UNITED... MAMMALS General Exceptions § 18.27 Regulations governing small takes of marine mammals incidental to...) of the Marine Mammal Protection Act of 1972, as amended, 16 U.S.C. 1371(a)(5), which provides a...

  18. 50 CFR 18.27 - Regulations governing small takes of marine mammals incidental to specified activities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... marine mammals incidental to specified activities. 18.27 Section 18.27 Wildlife and Fisheries UNITED... MAMMALS General Exceptions § 18.27 Regulations governing small takes of marine mammals incidental to...) of the Marine Mammal Protection Act of 1972, as amended, 16 U.S.C. 1371(a)(5), which provides a...

  19. Options for state and local governments to regulate non-cigarette tobacco products.

    PubMed

    Freiberg, Michael

    2012-01-01

    Most tobacco control laws were written to address the scourge of smoking--particularly smoking cigarettes. As a result, these laws frequently exclude non-cigarette tobacco products, which are becoming more prevalent on the market. These regulatory gaps jeopardize public health by increasing the possibility that these products will be used--particularly by minors and young adults. This article examines gaps in regulation using five products as case studies: dissolvable tobacco products, electronic cigarettes, little cigars, snus, and water pipes. In addition, this article presents policy options that state and local governments can adopt to regulate these products more effectively, including regulations relating to price, flavors, youth access, use in public places, point-of-sale warnings, and marketing. Furthermore, this article contains extensive discussion of the recently adopted federal Family Smoking Prevention and Tobacco Control Act, which both limits and expands the power of state and local governments.

  20. Regulations governing the out-of-state practice of psychology: implications for forensic neuropsychologists.

    PubMed

    Yantz, Christine L; Bauer, Lyndsey; McCaffrey, Robert J

    2006-01-01

    Many states allow psychologists licensed in other jurisdictions to practice temporarily without obtaining a full license. However, both the restrictions of practice and the procedures required before practice is allowed vary extensively among states. This article examines the regulations of U.S. and Canadian territories governing temporary practice of nonresident psychologists. Current licensing laws were obtained from each state's respective psychological board or related Web sites from May to July 2004. Results highlighted vast regulatory and procedural differences for temporary practice among jurisdictions. Due to the degree of variability in each jurisdiction's regulations governing, caution must be taken so that psychologists comply with up-to-date guidelines before practicing outside of the regions in which they are licensed. The out-of-state psychologist must contact the appropriate state or provincial licensing board for guidelines and pertinent regulation.

  1. Limiting the Influence of Pharmaceutical Industry Gifts on Physicians: Self-Regulation or Government Intervention?

    PubMed Central

    2009-01-01

    Concerns over the influence of pharmaceutical gifts on physicians have surged in recent years. This has prompted wide ranging legislative proposals in numerous states and in the federal government as well as stepped up efforts at self-regulation by the pharmaceutical industry and the medical profession. Policymakers face the decision of whether to defer to self-regulation or support government intervention. This commentary describes efforts at self-regulation by the pharmaceutical industry and the medical profession. The author examines and critiques the wide ranging legislative strategies pursued to limit the influence of pharmaceutical gifts on physicians and concludes with suggestions for policymakers and the profession to limit influence and preserve public trust. PMID:19756874

  2. Regulation of above ground storage tank emissions (Rube Goldberg and the reinvention of government)

    SciTech Connect

    Ferry, R.L.

    1997-05-01

    Much fanfare has been made of the Clinton administration`s reinvention of government. In the environmental arena, this is expressed as a sensitivity to the overlapping and duplicate nature of EPA regulations and the associated burden to perform unnecessary monitoring, recordkeeping, and reporting. While EPA has put forth numerous initiatives bearing labels such as simplification, burden reduction, and common sense, this reinvention has taken on a form that only Rube Goldberg could love. The overall outcome seems to be that a byzantine system of overlapping regulations with an associated monumental paperwork burden is now being buried under a byzantine system of overlapping simplification initiatives which carry an additional reporting and recordkeeping burden. This paper will examine the impact of these EPA actions on the regulations governing emissions from aboveground storage tanks.

  3. Government can regulate food advertising to children because cognitive research shows that it is inherently misleading.

    PubMed

    Graff, Samantha; Kunkel, Dale; Mermin, Seth E

    2012-02-01

    The childhood obesity crisis has prompted repeated calls for government action to curb the marketing of unhealthy food to children. Food and entertainment industry groups have asserted that the First Amendment prohibits such regulation. However, case law establishes that the First Amendment does not protect "inherently misleading" commercial speech. Cognitive research indicates that young children cannot effectively recognize the persuasive intent of advertising or apply the critical evaluation required to comprehend commercial messages. Given this combination--that government can prohibit "inherently misleading" advertising and that children cannot adequately understand commercial messages--advertising to children younger than age twelve should be considered beyond the scope of constitutional protection.

  4. Participatory health impact assessment for the development of local government regulation on hazard control

    SciTech Connect

    Inmuong, Uraiwan; Rithmak, Panee; Srisookwatana, Soomol; Traithin, Nathathai; Maisuporn, Pornpun

    2011-07-15

    The Thai Public Health Act 1992 required the Thai local governments to issue respective regulations to take control of any possible health-hazard related activities, both from commercial and noncommercial sources. Since 1999, there has been centrally decentralized of power to a new form of local government establishment, namely Sub-district Administrative Organization (SAO). The SAO is asmall-scale local governing structure while its legitimate function is for community services, including control of health impact related activities. Most elected SAO administrators and officers are new and less experience with any of public health code of practice, particularly on health-hazard control. This action research attempted to introduce and apply a participatory health impact assessment (HIA) tool for the development of SAO health-hazard control regulation. The study sites were at Ban Meang and Kok See SAOs, Khon Kaen Province, Thailand, while all intervention activities conducted during May 2005-April 2006. A set of cooperative activities between researchers and community representatives were planned and organized by; surveying and identifying place and service base locally causing local environmental health problems, organizing community participatory workshops for drafting and proposing the health-hazard control regulation, and appropriate practices for health-hazard controlling measures. This action research eventually could successfully enable the SAO administrators and officers understanding of local environmental-related health problem, as well as development of imposed health-hazard control regulation for local community.

  5. United States Government Regulations and International Standards Related to Food Analysis

    NASA Astrophysics Data System (ADS)

    Nielsen, S. Suzanne

    Knowledge of government regulations relevant to the chemical analysis of foods is extremely important to persons working in the food industry. Federal laws and regulations reinforce the efforts of the food industry to provide wholesome foods, to inform consumers about the nutritional composition of foods, and to eliminate economic frauds. In some cases, they dictate what ingredients a food must contain, what must be tested, and the procedures used to analyze foods for safety factors and quality attributes. This chapter describes the US federal regulations related to the composition of foods. The reader is referred to references (1-4) for comprehensive coverage of US food laws and regulations. Many of the regulations referred to in this chapter are published in the various titles of the Code of Federal Regulations (CFR) (5). This chapter also includes information about food standards and safety practices established by international organizations. Internet addresses are given at the end of this chapter for many of the government agencies, organizations, and documents discussed.

  6. 20 CFR 220.37 - When a child's disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) Inclusion as a disabled child in the employee's annuity rate under the social security overall minimum. (2... governed by the regulations of the Social Security Administration. 220.37 Section 220.37 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.37 When...

  7. 49 CFR 350.341 - What specific variances from the FMCSRs are allowed for State laws and regulations governing...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... allowed for State laws and regulations governing motor carriers, CMV drivers, and CMVs engaged in... governing motor carriers, CMV drivers, and CMVs engaged in intrastate commerce and not subject to Federal..., including the driver. (b) State laws and regulations applicable to intrastate commerce may not...

  8. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs...

  9. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs...

  10. 49 CFR 350.341 - What specific variances from the FMCSRs are allowed for State laws and regulations governing...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... allowed for State laws and regulations governing motor carriers, CMV drivers, and CMVs engaged in... governing motor carriers, CMV drivers, and CMVs engaged in intrastate commerce and not subject to Federal..., including the driver. (b) State laws and regulations applicable to intrastate commerce may not...

  11. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... regulations to govern exercise of mineral rights reserved in conveyances to the United States. 251.15 Section... Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... obedience thereto: (1) Whoever undertakes to exercise the reserved rights shall give prior written notice...

  12. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... regulations to govern exercise of mineral rights reserved in conveyances to the United States. 251.15 Section... Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... obedience thereto: (1) Whoever undertakes to exercise the reserved rights shall give prior written notice...

  13. 36 CFR 251.14 - Conditions, rules and regulations to govern exercise of timber rights reserved in conveyance to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations to govern exercise of timber rights reserved in conveyance to the United States. 251.14 Section... Miscellaneous Land Uses Natural Resources Control § 251.14 Conditions, rules and regulations to govern exercise... undertakes to exercise the reserved rights, hereinafter called operator, shall give prior written notice...

  14. 36 CFR 251.15 - Conditions, rules and regulations to govern exercise of mineral rights reserved in conveyances to...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... regulations to govern exercise of mineral rights reserved in conveyances to the United States. 251.15 Section... Miscellaneous Land Uses Natural Resources Control § 251.15 Conditions, rules and regulations to govern exercise... obedience thereto: (1) Whoever undertakes to exercise the reserved rights shall give prior written notice...

  15. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulated articles from quarantined areas. 301.51-4 Section 301.51-4 Agriculture Regulations of the... DOMESTIC QUARANTINE NOTICES Asian Longhorned Beetle § 301.51-4 Conditions governing the interstate movement of regulated articles from quarantined areas. (a) Any regulated article may be moved interstate from...

  16. Privatized biomedical research, public fears, and the hazards of government regulation: lessons from stem cell research.

    PubMed

    Resnik, D B

    1999-01-01

    This paper discusses the hazards of regulating controversial biomedical research in light of the emergence of powerful, multi-national biotechnology corporations. Prohibitions on the use of government funds can simply force controversial research into the private sphere, and unilateral or multilateral research bans can simply encourage multi-national companies to conduct research in countries that lack restrictive laws. Thus, a net effect of government regulation is that research migrates from the public to the private sphere. Because private research receives less oversight and external scrutiny than public research, it can threaten the welfare and rights of human subjects, scientific progress and openness, and the quality of the approval process for new biomedical technologies. In order to avoid the harmful effects of government regulation of biotechnology, society should promote meaningful discussion and dialogue among scientists, industry leaders, and the public before resorting to regulatory solutions. Legislative or executive initiatives should be applied with great discretion and care, and should be crafted in such a way that they protect public health and safety, promote scientific progress, and avoid the hazards of privatized research and polarized debates.

  17. Impact of government regulations on leadtimes of coal facilities. Final report

    SciTech Connect

    Singh, J.; Carboni, J.V.; Shah, D.V.; White, J.M. Jr.

    1980-08-01

    The ability of the US to increase coal use depends on the leadtimes required to bring from inception into operation: (1) new coal use facilities such as powerplants, industrial boilers, coke ovens, and coal-based synfuel plants; and (2) new coal facilities including surface mines, deep mines, coal preparation plants, and railroad lines. This study examines the effect of government regulations on the leadtimes for the following ten facilities: surface mines on federal land; surface mines - private surface/private coal; underground coal mines; coal preparation plants; railroad lines; coal-fired electric generating plants; coal-fired industrial facilities; coke plants; synthetic fuels; and transmission lines. Environmental activities consume a significant portion of critical path time for all facilities. The time spent for obtaining permits and licenses account for as much as 63% of total critical path time in the case of a new railroad line servicing a coal mine in the western US. For surface mines, permitting accounts for 33% of total project critical path; for underground mines, it is 43%. Permitting requires 26 and 42% of the critical paths for new industrial facilities and power plants, respectively. Long durations of critical environmental activities account for much of the uncertainty surrounding the approval of large coal projects. Government regulations have also affected the way companies conduct their business. Dealing with government regulations has become as important to the completion of new coal facilities as project financing, design, and construction.

  18. Governance strategies for living technologies: bridging the gap between stimulating and regulating technoscience.

    PubMed

    van Est, Rinie; Stemerding, Dirk

    2013-01-01

    The life sciences present a politically and ethically sensitive area of technology development. NBIC convergence-the convergence of nanotechnology, biotechnology, and information and cognitive technology-presents an increased interaction between the biological and physical sciences. As a result the bio-debate is no longer dominated by biotechnology, but driven by NBIC convergence. NBIC convergence enables two bioengineering megatrends: "biology becoming technology" and "technology becoming biology." The notion of living technologies captures the latter megatrend. Accordingly, living technology presents a politically and ethically sensitive area. This implies that governments sooner or later are faced with the challenge of both promoting and regulating the development of living technology. This article describes four current political models to deal with innovation promotion and risk regulation. Based on two specific developments in the field of living technologies-(psycho)physiological computing and synthetic biology-we reflect on appropriate governance strategies for living technologies. We conclude that recent pleas for anticipatory and deliberative governance tend to neglect the need for anticipatory regulation as a key factor in guiding the development of the life sciences from a societal perspective. In particular, when it is expected that a certain living technology will radically challenge current regulatory systems, one should opt for just such a more active biopolitical approach.

  19. Government regulation of gambling advertising: Replacing vice prevention with consumer protection.

    PubMed

    Rothman, M; Robbins, H

    1991-12-01

    From 1895 to 1975, federal law forbade gambling advertising by use of the mail, interstate commerce, and the broadcast media. Congress exempted state lotteries in 1975 and charitable gambling (including casino games) in 1988. However, the Supreme Court requires a significant government interest, directly applied and narrowly tailored, in order to justify a commercial speech regulation. The exemptions for private charity casino games has arguably destroyed any constitutionally defensible government interest in restricting for-profit casinos. Casinos in new gambling jurisdictions (such as Iowa or Illinois) will probably push the hardest for an exemption for all legal gambling, as they have the most to gain from the freedom to advertise. Federal regulation of gambling advertising will fall to the Federal Trade Commission under prohibitions against "unfair or deceptive" trade practices. But as State regulations are not well developed even in states that permit casino gambling, there is a pressing need for new research to review state laws regulating gambling advertising and to propose a model statute.

  20. Governance of nanotechnology and nanomaterials: principles, regulation, and renegotiating the social contract.

    PubMed

    Kimbrell, George A

    2009-01-01

    Good governance for nanotechnology and nanomaterials is predicated on principles of general good governance. This paper discusses on what lessons we can learn from the oversight of past emerging technologies in formulating these principles. Nanotechnology provides us a valuable opportunity to apply these lessons and a duty to avoid repeating past mistakes. To do that will require mandatory regulation, grounded in precaution, that takes into account the uniqueness of nanomaterials. Moreover, this policy dialogue is not taking place in a vacuum. In applying the lessons of the past, nanotechnology provides a window to renegotiate our public's social contract on chemicals, health, the environment, and risks. Emerging technologies illuminate structural weaknesses, providing a crucial chance to ameliorate lingering regulatory inadequacies and provide much needed updates of existing laws.

  1. [Changes in the regulation and government of the health system. SESPAS report 2014].

    PubMed

    Repullo, José R

    2014-06-01

    The economic and fiscal crisis of 2008 has erupted into the debate on the sustainability of health systems; some countries, such as Spain, have implemented strong policies of fiscal consolidation and austerity. The institutional framework and governance model of the national health system (NHS) after its devolution to regions in 2002 had significant weaknesses, which were not apparent in the rapid growth stage but which have been clearly visible since 2010. In this article, we describe the changes in government regulation from the national and NHS perspective: both general changes (clearly prompted by the economic authorities), and those more specifically addressed to healthcare. The Royal Decree-Law 16/2012 represents the centerpiece of austerity policies in healthcare but also implies a rupture with existing political consensus and a return to social security models. Our characterization of austerity in healthcare explores impacts on savings, services, and on the healthcare model itself, although the available information only allows some indications. The conclusions highlight the need to change the path of linear, rapid and radical budget cuts, providing a time-frame for implementing key reforms in terms of internal sustainability; to do so, it is appropriate to restore political and institutional consensus, to emphasize "clinical management" and divestment of inappropriate services (approach to the medical profession and its role as micro-manager), and to create frameworks of good governance and organizational innovations that support these structural reforms.

  2. Governing peanuts: the regulation of the social bodies of children and the risks of food allergies.

    PubMed

    Rous, Trevor; Hunt, Alan

    2004-02-01

    This paper explores the way in which children with life-threatening food allergies, their parents and their public caregivers have increasingly been made subject to both projects of moral regulation and mechanism of governance aimed at the management of risk. We argue that new regulatory measures in Canada designed to significantly change the food consumption practices among children in elementary schools have three main consequences. First, they structure the relationship between ideologies of individualism and community so as to blur the distinction between the public and private dimensions of school life. Second, such efforts ensure that a discourse, formerly concerned with the problem of health promotion, has been supplanted by new sets of discourses styled by absent experts that focus on the management of risk. Third, such regulatory practices have a particular dual effect that is characteristic of liberal welfare governance. On the one hand, they encourage the individualized development of self-governing subjects, and on the other, they stimulate a heightened moral problematization of 'safe' eating habits within the environment of the elementary school.

  3. From Hippocrates to Commodities: three models of NHS governance: NHS governance, regulation, Mid Staffordshire inquiry, health care as a commodity.

    PubMed

    Newdick, Christopher

    2014-01-01

    A series of inquiries and reports suggest considerable failings in the care provided to some patients in the NHS. Although the Bristol Inquiry report of 2001 led to the creation of many new regulatory bodies to supervise the NHS, they have never enjoyed consistent support from government and the Mid Staffordshire Inquiry in 2013 suggests they made little difference. Why do some parts of the NHS disregard patients' interests and how we should we respond to the challenge? The following discusses the evolution of approaches to NHS governance through the Hippocratic, Managerial and Commercial models, and assesses their risks and benefits. Apart from the ethical imperative, the need for effective governance is driven both by the growth in information available to the public and the resources wasted by ineffective systems of care. Appropriate solutions depend on an understanding of the perverse incentives inherent in each model and the need for greater sensitivity to the voices of patients and the public.

  4. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  5. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... is governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  6. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  7. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... is governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  8. 20 CFR 220.38 - When a widow(er)'s disability determination is governed by the regulations of the Social Security...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... is governed by the regulations of the Social Security Administration. 220.38 Section 220.38 Employees... Disability Determinations Governed by the Regulations of the Social Security Administration § 220.38 When a widow(er)'s disability determination is governed by the regulations of the Social...

  9. Mornings with Art, lessons learned: feedback regulation, restriction threshold biology, and redundancy govern molecular stress responses.

    PubMed

    Bey, Erik A; Wuerzberger-Davis, Shelly M; Pink, John J; Yang, Chin-Rang; Araki, Shinako; Reinicke, Kathryn E; Bentle, Melissa S; Dong, Ying; Cataldo, Eva; Criswell, Tracy L; Wagner, Mark W; Li, Longshan; Gao, Jinming; Boothman, David A

    2006-12-01

    Work from the laboratory of Dr. Arthur B. Pardee has highlighted basic principles that govern cellular and molecular biological processes in living cells. Among the most important governing principles in cellular and molecular responses are: (i) threshold "restriction" responses, wherein a level of response is reached and a "point of no return" is achieved; (ii) feedback regulation; and (iii) redundancy. Lessons learned from the molecular biology of cellular stress responses in mammalian cancer versus normal cells after ionizing radiation (IR) or chemotherapeutic agent exposures reveal similar instances of these guiding principles in mammalian cells. Among these are the: (i) induction of cell death responses by beta-lapachone (beta-lap), a naphthoquinone anti-tumor agent that kills cancer cells via an NQO1 (i.e., X-ray-inducible protein-3, xip3)-dependent mechanism; (ii) induction of secretory clusterin (sCLU) in response to TGF-beta1 exposure, and the ability of induced sCLU protein to down-regulate TGF-beta1 signaling; and (iii) induction of DNA mismatch repair-dependent G(2) cell cycle checkpoint responses after exposure to alkylating agents. We have learned these lessons and now adopted strategies to exploit them for improved therapy. These examples will be discussed and compared to the pioneering findings of researchers in the Pardee laboratory over the years. (c) 2006 Wiley-Liss, Inc.

  10. 78 FR 30784 - Removal of References to Credit Ratings in Certain Regulations Governing the Federal Home Loan Banks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... Regulations Governing the Federal Home Loan Banks AGENCY: Federal Housing Finance Agency. ACTION: Notice of... requirements in certain safety and soundness regulations affecting the Federal Home Loan Banks (Banks) and to adopt new provisions that would require the Banks to apply internal analytic standards and criteria...

  11. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on the...

  12. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on the...

  13. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on the...

  14. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on the...

  15. 7 CFR 301.74-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Plum Pox § 301.74-4 Conditions governing the interstate movement of regulated... Departmental permit and found by the Administrator to be adequate to prevent the spread of plum pox; and (4... plum pox while in the quarantined area; (2) The regulated article's point of origin is indicated on the...

  16. 49 CFR 350.341 - What specific variances from the FMCSRs are allowed for State laws and regulations governing...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... based upon the distance a motor carrier or driver operates from the work reporting location. This... allowed for State laws and regulations governing motor carriers, CMV drivers, and CMVs engaged in... Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT...

  17. 49 CFR 350.341 - What specific variances from the FMCSRs are allowed for State laws and regulations governing...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... based upon the distance a motor carrier or driver operates from the work reporting location. This... allowed for State laws and regulations governing motor carriers, CMV drivers, and CMVs engaged in... Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT...

  18. Oil on the water: Government regulation of a carcinogen in the twentieth-century Lancashire cotton spinning industry.

    PubMed

    Higgins, David; Tweedale, Geoffrey

    2010-01-01

    In the Lancashire cotton textile industry, mule spinners were prone to a chronic and sometimes fatal skin cancer (often affecting the groin). The disease had reached epidemic proportions by the 1920s, which necessitated action by the government, employers, and trade unions. In contrast to previous accounts, this article focuses on the government's reaction to mule spinners' cancer. Using official records in the National Archives, the slow introduction of health and safety measures by the government is explored in detail. Although obstructionism by the employers played a key role, one of the reasons for government inaction was the ambiguity of scientific research on engineering oils. On the other hand, prolonged scientific research suited a government policy that was framed around self regulation - a policy that had proved largely ineffective by the 1950s.

  19. Private governance, public purpose? Assessing transparency and accountability in self-regulation of food advertising to children.

    PubMed

    Reeve, Belinda

    2013-06-01

    Reducing non-core food advertising to children is an important priority in strategies to address childhood obesity. Public health researchers argue for government intervention on the basis that food industry self-regulation is ineffective; however, the industry contends that the existing voluntary scheme adequately addresses community concerns. This paper examines the operation of two self-regulatory initiatives governing food advertising to children in Australia, in order to determine whether these regulatory processes foster transparent and accountable self-regulation. The paper concludes that while both codes appear to establish transparency and accountability mechanisms, they do not provide for meaningful stakeholder participation in the self-regulatory scheme. Accordingly, food industry self-regulation is unlikely to reflect public health concerns or to be perceived as a legitimate form of governance by external stakeholders. If industry regulation is to remain a feasible alternative to statutory regulation, there is a strong argument for strengthening government oversight and implementing a co-regulatory scheme.

  20. 78 FR 32945 - Amendments to Regulations Governing Ocean Transportation Intermediary Licensing and Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ... Ocean Transportation Intermediary Licensing and Financial Responsibility Requirements, and General... Governing Ocean Transportation Intermediary Licensing and Financial Responsibility Requirements, and General... Federal Maritime Commission proposes to amend its rules governing the licensing, financial...

  1. Reimbursement To Local Governments For Emergency Response To Hazardous Substance Releases Regulation Overview

    EPA Pesticide Factsheets

    The purpose of the Local Governments Reimbursement (LGR) program is to provide funds, in the form of reimbursements for expenses, to local, county, and tribal governments that respond to a hazardous substance release in their jurisdiction.

  2. 26 CFR 31.3402(t)-0 - Outline of the Government withholding regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... passthrough entity. (d) Payments to a passthrough entity. (e) Effective/applicability date. 31.3402(t....3402(t)-7. 31.3402(t)-1Withholding requirement on certain payments made by government entities. (a) In....3402(t)-2Government entities required to withhold under section 3402(t). (a) In general. (b) Government...

  3. 75 FR 25160 - Defense Federal Acquisition Regulation Supplement; Marking of Government-Furnished Property...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ...-furnished property identified in the contract when the Government-furnished material and Government- furnished property are subject to serialized item management. DATES: Comments on the proposed rule should be... Supplement; Marking of Government-Furnished Property (DFARS Case 2008-D050) AGENCY: Defense...

  4. 75 FR 33734 - Regulations Affecting Publication of the United States Government Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... transferred to the Office of the Federal Register from the Office of Government Reports within the Bureau of... From the Federal Register Online via the Government Publishing Office #0; #0;Proposed Rules #0... the United States Government Manual AGENCY: Administrative Committee of the Federal Register....

  5. Impact of government regulations on leadtimes of coal facilities. Final report

    SciTech Connect

    Not Available

    1980-08-01

    The ability of the US to increase coal use depends on the leadtimes required to bring from inception into operation: (1) new coal use facilities such as powerplants, industrial boilers, coke ovens, and coal-based synfuel plants; and (2) new coal facilities including surface mines, deep mines, coal preparation plants, and railroad lines. This study examines the effect of government regulations on the leadtimes for the following ten facilities: surface mines on federal land; surface mines - private surface/private coal; underground coal mines; coal preparation plants; railroad lines; coal-fired electric generating plants; coal-fired industrial facilities; coke plants; synthetic fuels; and transmission lines. These appendices contain summaries of legislation affecting the above coal facilities. Discussed are: the Clean Air Act; National Environmental Policy Act; Federal Coal Leasing Amendments Act; Surface Mining Control and Reclamation Act; Federal Land Policy and Management Act; River and Harbors Act; Federal Mine Health and Safety Amendments Act; Fish and Wildlife Coordination Act; National Historic Preservation Act; Endangered Species Act; the Clear Water Act; and the Resource Conservation and Recovery Act. (DMC)

  6. Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression

    PubMed Central

    Chen, Chider; Akiyama, Kentaro; Yamaza, Takayoshi; You, Yong-Ouk; Xu, Xingtian; Li, Bei; Zhao, Yimin; Shi, Songtao

    2014-01-01

    Bone marrow mesenchymal stem cells (BMMSCs) are capable of differentiating into multiple cell types and regulating immune cell response. However, the mechanisms that govern the immunomodulatory properties of BMMSCs are still not fully elucidated. Here we show that telomerase-deficient BMMSCs lose their capacity to inhibit T cells and ameliorate the disease phenotype in systemic sclerosis mice. Restoration of telomerase activity by telomerase reverse transcriptase (TERT) transfection in TERT−/− BMMSCs rescues their immunomodulatory functions. Mechanistically, we reveal that TERT, combined with β-catenin and BRG1, serves as a transcriptional complex, which binds the FAS ligand (FASL) promoter to upregulate FASL expression, leading to an elevated immunomodulatory function. To test the translational value of these findings in the context of potential clinical therapy, we used aspirin treatment to upregulate telomerase activity in BMMSCs, and found a significant improvement in the immunomodulatory capacity of BMMSCs. Taken together, these findings identify a previously unrecognized role of TERT in improving the immunomodulatory capacity of BMMSCs, suggesting that aspirin treatment is a practical approach to significantly reduce cell dosage in BMMSC-based immunotherapies. Subject Categories Stem Cells; Immunology PMID:24401839

  7. Health and social care regulation in Wales: an integrated system of political, corporate and professional governance for improving public health.

    PubMed

    Jewell, Tony; Wilkinson, Jane

    2008-11-01

    Wales is developing a unique integrated system of governance to improve public health, which is diverging from some recent developments in the rest of the UK but shares many common features. There is a focus on strengthening collaborative working and co-ordination between bodies inspecting, regulating and auditing health and social care. Systems are being developed that are proportionate to the level of risk, eliminate unnecessary burdens of external review and support the improvement of services for patients, service users and carers. This is consistent with the Assembly Government's aim to improve the way that public services are delivered in Wales, including strengthening input from the public in the planning, delivery and reporting of regulation and inspection work. The test in the future will be how far we can demonstrate quantitatively and qualitatively the added value from our uniquely Welsh approach, built as it is on devolution and the aspirations for small-country governance.

  8. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours...

  9. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and... through E and H of part 107, and §§ 171.15 and 171.16, as applicable to either interstate or...

  10. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours of...

  11. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours of...

  12. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours of...

  13. 7 CFR 301.48-4 - Conditions governing the interstate movement of regulated articles from quarantined States.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Japanese Beetle Quarantine and Regulations § 301.48-4 Conditions governing the... threat to spread the Japanese beetle because adult beetle populations are not present; or (b) The... be free of and safeguarded against Japanese beetle; or (c) The aircraft is loaded during the hours of...

  14. Fifty Educational Markets: A Playbook of State Laws and Regulations Governing Private Schools. School Choice Issues in Depth

    ERIC Educational Resources Information Center

    Hammons, Christopher

    2008-01-01

    There is a widespread misperception that private schools avoid government oversight or are "unregulated." In fact, private schools are subject to a wide variety of laws and regulations that run the gamut from reasonable rules to ensure health and safety to unreasonable rules that interfere with school curricula, preventing schools from pursuing…

  15. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and... through E and H of part 107, and §§ 171.15 and 171.16, as applicable to either interstate or...

  16. 49 CFR 350.337 - How may State laws and regulations governing motor carriers, CMV drivers, and CMVs in interstate...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and still be considered... regulations governing motor carriers, CMV drivers, and CMVs in interstate commerce differ from the FMCSRs and... through E and H of part 107, and §§ 171.15 and 171.16, as applicable to either interstate or intrastate...

  17. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Applicable Federal Statutes, Executive Orders, and Government-wide Regulations A Appendix A to Part 603 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE.... Prohibitions on discrimination on the basis of race, color, or national origin in Title VI of the Civil Rights...

  18. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Applicable Federal Statutes, Executive Orders, and Government-wide Regulations A Appendix A to Part 603 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE.... Prohibitions on discrimination on the basis of race, color, or national origin in Title VI of the Civil Rights...

  19. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  20. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  1. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  2. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  3. 7 CFR 301.52-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-3 Conditions governing the... present a hazard of the spread of the pink bollworm and the person in possession thereof has been so... articles has been notified by an inspector that a hazard of spread of the pink bollworm exists; or...

  4. 10 CFR Appendix A to Part 603 - Applicable Federal Statutes, Executive Orders, and Government-wide Regulations

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Applicable Federal Statutes, Executive Orders, and Government-wide Regulations A Appendix A to Part 603 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE... sources of drinking water. 4. If the project may impact a historic property, it is subject to the...

  5. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  6. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  7. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  8. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  9. 7 CFR 301.45-4 - Conditions governing the interstate movement of regulated articles and outdoor household articles...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Gypsy Moth § 301.45-4 Conditions governing... gypsy moth life stages. (c) A regulated article originating in a generally infested area may be moved... adequate to prevent the dissemination of the gypsy moth, i.e., conditions of treatment,...

  10. The Regulation of Peace River: a Large-scale Experiment on Fluvial Governing Conditions

    NASA Astrophysics Data System (ADS)

    Church, M.

    2004-12-01

    In 1967, British Columbia Hydro and Power Authority closed W.A.C.Bennett Dam, creating what was then the sixth largest hydropower project in the world. The dam is located in the Rocky Mountain front range so that, although it controls about half the runoff of the 293 000 sq.km basin, almost all of the sediment load originates downstream from the dam in the Alberta Plateau. Hence, the effects of these two principal governing conditions of fluvial systems can be separated. The 378 km immediately downstream to the Smoky River confluence are a wandering, cobble-gravel reach It has effectively ceased to be alluvial and the channel pattern has been simplified. Aggradation is occurring at major tributary junctions, whilst the tributaries themselves have degraded in their lowermost reaches. Smoky River, the principal tributary, delivers a large sand load. The 250 km reach to Carcajou is sandy gravel and the final 600 km to the Peace-Athabasca delta is sand-bed. Aggradation, with a change in fluvial style toward low-order braiding, appears to be underway in the proximal sand-bed reach. More generally, channel shrinkage in response to the regulated flow regime is controlled by the rate of progradation of riparian vegetation onto former bar surfaces In 1996, after 29 years of regulated flow, reservoir drawdown for dam repairs led to full spillway flows for 8 consecutive weeks, creating an effectively bankfull condition in the proximal post-regulation channel. Significant degradation was observed for the first time in many cross-sections but overall changes were surprisingly modest, reflecting the refractory bed and the degree to which riparian vegetation has become firmly established in former channel areas. Overall, sediment supply and flow competence are the principal controls of fluvial response in the system. The experimental aspect of this study of a large, northward flowing, boreal river can be controlled by before-after comparison. However, this strategy must take into

  11. Governance reform, external support, and environmental regulation enforcement in rural China: the case of Guangdong province.

    PubMed

    Tang, Shui-Yan; Lo, Carlos Wing-Hung; Fryxell, Gerald E

    2010-10-01

    This paper examines how configurations of external support factors have evolved alongside governance reform in recent years and how these evolving configurations have affected regulatory enforcement in four counties in Guangdong Province in China. Based on in-depth interviews with leading officials in the local environmental protection bureaus (EPBs), we show that there have been increases in government and societal support for local EPBs in their regulatory work, thanks partly to a number of recent governance reform efforts, but many problems have remained. Based on a questionnaire survey of enforcement officials, we examine how the perceptions of government and societal support are related to EPB officials' self-perception of effectiveness. It is found that both local government support and societal support have an influence on enforcement officials' self-assessment of effectiveness, but the relationships varied considerably depending on various dimensions of effectiveness and the patterns of interactions between government and societal support.

  12. 78 FR 42921 - Amendments to Regulations Governing Ocean Transportation Intermediary Licensing and Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... Licensing and Financial Responsibility Requirements, and General Duties AGENCY: Federal Maritime Commission... Commission proposes to amend its rules governing the licensing, financial responsibility requirements...

  13. Reflections on different governance styles in regulating science: a contribution to 'Responsible Research and Innovation'.

    PubMed

    Landeweerd, Laurens; Townend, David; Mesman, Jessica; Van Hoyweghen, Ine

    2015-01-01

    In European science and technology policy, various styles have been developed and institutionalised to govern the ethical challenges of science and technology innovations. In this paper, we give an account of the most dominant styles of the past 30 years, particularly in Europe, seeking to show their specific merits and problems. We focus on three styles of governance: a technocratic style, an applied ethics style, and a public participation style. We discuss their merits and deficits, and use this analysis to assess the potential of the recently established governance approach of 'Responsible Research and Innovation' (RRI). Based on this analysis, we reflect on the current shaping of RRI in terms of 'doing governance'.

  14. Government regulation and public opposition create high additional costs for field trials with GM crops in Switzerland.

    PubMed

    Bernauer, Thomas; Tribaldos, Theresa; Luginbühl, Carolin; Winzeler, Michael

    2011-12-01

    Field trials with GM crops are not only plant science experiments. They are also social experiments concerning the implications of government imposed regulatory constraints and public opposition for scientific activity. We assess these implications by estimating additional costs due to government regulation and public opposition in a recent set of field trials in Switzerland. We find that for every Euro spent on research, an additional 78 cents were spent on security, an additional 31 cents on biosafety, and an additional 17 cents on government regulatory supervision. Hence the total additional spending due to government regulation and public opposition was around 1.26 Euros for every Euro spent on the research per se. These estimates are conservative; they do not include additional costs that are hard to monetize (e.g. stakeholder information and dialogue activities, involvement of various government agencies). We conclude that further field experiments with GM crops in Switzerland are unlikely unless protected sites are set up to reduce these additional costs.

  15. Regulation of HSV glycoprotein induced cascade of events governing cell-cell fusion.

    PubMed

    Atanasiu, Doina; Saw, Wan Ting; Eisenberg, Roselyn J; Cohen, Gary H

    2016-09-14

    Receptor dependent HSV-induced fusion requires glycoproteins gD, gH/gL, and gB. Our current model posits that during fusion receptor-activated conformational changes in gD activate gH/gL, which subsequently triggers transformation of the pre-fusion form of gB into a fusogenic state. To examine the role of each glycoprotein in receptor dependent cell-cell fusion we took advantage of our discovery that fusion by wild type HSV-2 glycoproteins occurs twice as fast as that achieved by HSV-1 glycoproteins. By sequentially swapping each glycoprotein between the two serotypes, we established that fusion speed was governed by gH/gL, with gH being the main contributor. While the mutant forms of gB fuse at distinct rates that are dictated by their molecular structure, these restrictions can be overcome by gH2/gL2, thereby enhancing their activity. We also found that deregulated forms of gD1 and gH2/gL2 can alter the fusogenic potential of gB, promoting cell fusion in the absence of a cellular receptor and that deregulated forms of gB can drive the fusion machinery to even higher levels. Low pH enhanced fusion by affecting the structure of both gB and gH/gL mutants. Together, our data highlight the complexity of the fusion machinery, the impact of the activation state of each glycoprotein on the fusion process and the critical role of gH/gL in regulating HSV induced fusion.

  16. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element.

    PubMed

    Qian, Yi; Yin, Chunyang; Chen, Yue; Zhang, Shuping; Jiang, Li; Wang, Fudi; Zhao, Meirong; Liu, Sijin

    2015-05-01

    Ferroportin (FPN) is the only known iron exporter in mammalian cells, and is universally expressed in most types of cells. FPN signaling plays a crucial role in maintaining iron homeostasis through governing the level of intracellular iron. Serum iron storage is conversely related with the estrogen level in the female bodies, and women in post-menopause are possibly subjected to iron retention. However, the potential effects of estrogen on iron metabolism are not clearly understood. Here, FPN mRNA transcription in all selected estrogen receptor positive (ER+) cells was significantly reduced upon 17β-estradiol (E2) treatment; and this inhibitory effect could be attenuated by ER antagonist tamoxifen. Likewise, in murine bone marrow-derived macrophages (BMDMs), FPN reduction with elevated intracellular iron (reflected by increased ferritin) was observed in response to E2; however, ferritin level barely responded to E2 in FPN-null BMDMs. The observation of inhibition of FPN mRNA expression was not replicated in ER(-) cells upon E2. A functional estrogen response element (ERE) was identified within the promoter of FPN, and this ERE was responsible for the suppressive effect of E2 on FPN expression. Moreover, ovariectomized (OVX) and sham-operated (SHAM) mice were used to further confirm the in vitro finding. The expression of hepatic FPN was induced in OVX mice, compared to that in the SHAM mice. Taken together, our results demonstrated that estrogen is involved in regulating FPN expression through a functional ERE on its promoter, providing additional insights into a vital role of estrogen in iron metabolism.

  17. Ontario Education Governance 1995 to the Present: More Accountability, More Regulation, and More Centralization?

    ERIC Educational Resources Information Center

    Li, Xiaobin

    2015-01-01

    The purpose of this study was to examine the general trend of education governance in the Canadian province of Ontario since 1995 when the Progressive Conservatives led by Michael Harris formed a new majority government. The article is divided into three sections. The first section provides the context and a historical background of Ontario…

  18. 77 FR 22267 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ....gov/oca/12tables/html/por_h.asp ). \\2\\ 1.5 for employee benefits and other Government costs; 1.25 for... providing the service, resource, or good when the Government is acting in its capacity as sovereign.'' Thus... private entities to apply for programmatic long-term permits. ** Includes researching permit requirements...

  19. 76 FR 21852 - Defense Federal Acquisition Regulation Supplement; Responsibility and Liability for Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-19

    ...; Responsibility and Liability for Government Property (DFARS Case 2010-D018) AGENCY: Defense Acquisition... other than submission of certified cost or pricing data. FAR 45.104, Responsibility and liability for... read as follows: 245.104 Responsibility and liability for Government property. (a) In addition to...

  20. Governing through Prevent? Regulation and Contested Practice in State-Muslim Engagement.

    PubMed

    O'Toole, Therese; Meer, Nasar; DeHanas, Daniel Nilsson; Jones, Stephen H; Modood, Tariq

    2016-02-01

    In this article, we consider the implications of the 'Prevent' strand of the government's counter-terrorism strategy for the UK state's engagement with Muslims. We argue that the logics of Prevent have been highly problematic for state-Muslim engagement. Nevertheless, we suggest that the characterisation of state approaches to engaging Muslims as a form of discipline is incomplete without an analysis of: first, differences in practices, habits and perspectives across governance domains; second, variations in approach and implementation between levels of governance; and third, the agency of Muslims who engage with the state. Through this approach we show how attention to the situated practices of governance reveals the contested nature of governing through Prevent.

  1. Regulation of Herpes Simplex Virus Glycoprotein-Induced Cascade of Events Governing Cell-Cell Fusion

    PubMed Central

    Saw, Wan Ting; Eisenberg, Roselyn J.; Cohen, Gary H.

    2016-01-01

    ABSTRACT Receptor-dependent herpes simplex virus (HSV)-induced cell-cell fusion requires glycoproteins gD, gH/gL, and gB. Our current model posits that during fusion, receptor-activated conformational changes in gD activate gH/gL, which subsequently triggers the transformation of the prefusion form of gB into a fusogenic state. To examine the role of each glycoprotein in receptor-dependent cell-cell fusion, we took advantage of our discovery that fusion by wild-type herpes simplex virus 2 (HSV-2) glycoproteins occurs twice as fast as that achieved by HSV-1 glycoproteins. By sequentially swapping each glycoprotein between the two serotypes, we established that fusion speed was governed by gH/gL, with gH being the main contributor. While the mutant forms of gB fuse at distinct rates that are dictated by their molecular structure, these restrictions can be overcome by gH/gL of HSV-2 (gH2/gL2), thereby enhancing their activity. We also found that deregulated forms of gD of HSV-1 (gD1) and gH2/gL2 can alter the fusogenic potential of gB, promoting cell fusion in the absence of a cellular receptor, and that deregulated forms of gB can drive the fusion machinery to even higher levels. Low pH enhanced fusion by affecting the structure of both gB and gH/gL mutants. Together, our data highlight the complexity of the fusion machinery, the impact of the activation state of each glycoprotein on the fusion process, and the critical role of gH/gL in regulating HSV-induced fusion. IMPORTANCE Cell-cell fusion mediated by HSV glycoproteins requires gD, gH/gL, gB, and a gD receptor. Here, we show that fusion by wild-type HSV-2 glycoproteins occurs twice as fast as that achieved by HSV-1 glycoproteins. By sequentially swapping each glycoprotein between the two serotypes, we found that the fusion process was controlled by gH/gL. Restrictions imposed on the gB structure by mutations could be overcome by gH2/gL2, enhancing the activity of the mutants. Under low-pH conditions or when

  2. 75 FR 35684 - Defense Federal Acquisition Regulation Supplement; Ownership or Control by a Foreign Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-23

    ... Defense Acquisition Regulations System 48 CFR Parts 209 and 252 Defense Federal Acquisition Regulation... Regulations System, Department of Defense (DoD). ACTION: Interim rule with request for comments. SUMMARY: DoD... of the message. Fax: 703-602-0350. Mail: Defense Acquisition Regulations System, Attn: Mr. Julian...

  3. Trust in government and support for governmental regulation: the case of electronic health records.

    PubMed

    Herian, Mitchel N; Shank, Nancy C; Abdel-Monem, Tarik L

    2014-12-01

    This paper presents results from a public engagement effort in Nebraska, USA, which measured public opinions about governmental involvement in encouraging the use of electronic health records (EHRs). We examine the role of trust in government in contributing to public support for government involvement in the development of EHR technologies. We hypothesize that trust in government will lead to support for federal and state governmental encouragement of the use of EHRs among doctors and insurance companies. Further, because individual experiences with health-care professionals will reduce perceptions of risk, we expect that support for governmental involvement will be tempered by greater personal experience with the health-care industry. Examining a small survey of individuals on the issue, we find general support for both of our hypotheses. The findings suggest that trust in government does have a positive relationship with support for government involvement in the policy domain, but that the frequency of personal experiences with health-care providers reduces the extent to which the public supports governmental involvement in the development of EHR technology. This inquiry contributes to our understanding of public attitudes towards government involvement in EHRs in the United States specifically and contributes to social science examining links between trust in government and support for governmental activity in the emerging policy domain regarding electronic health records systems. © 2012 John Wiley & Sons Ltd.

  4. Synthetic biology regulation and governance: Lessons from TAPIC for the United States, European Union, and Singapore.

    PubMed

    Trump, Benjamin D

    2017-08-02

    Synthetic biology is an emerging technology with potential benefits to various fields, yet also contains potential risks to human and environmental health. The field remains in an emerging state with limited quantitative guidance and a small but growing population of international researchers that conduct work within this field. Given the uncertain nature of this technology, an adaptive and anticipatory governance framework may be necessary to balance the potential benefits that may accrue from the technology's continued research alongside a desire to reduce or eliminate potential risks that may arise. However, such developments must account for the unique political and institutional factors that form a government's risk culture - something that can facilitate or impede the development of adaptive synthetic biology governance moving forward. The TAPIC framework helps illustrate those factors that are essential to develop good governance for emerging technologies like synthetic biology. Specifically, an application of TAPIC to synthetic biology governance indicates that the factors of accountability, participation, and integrity must be bolstered to improve technology governance in governments like with the United States, European Union, and Singapore. Copyright © 2017. Published by Elsevier B.V.

  5. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds? 363.201 Section 363.201 Money and Finance... Securities § 363.201 What other regulations govern book-entry marketable book-entry Treasury bills,...

  6. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds? 363.201 Section 363.201 Money and Finance... Securities § 363.201 What other regulations govern book-entry marketable book-entry Treasury bills, notes...

  7. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds? 363.201 Section 363.201 Money and Finance... Securities § 363.201 What other regulations govern book-entry marketable book-entry Treasury bills, notes...

  8. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds? 363.201 Section 363.201 Money and Finance... Securities § 363.201 What other regulations govern book-entry marketable book-entry Treasury bills, notes...

  9. 31 CFR 363.201 - What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false What other regulations govern book-entry marketable book-entry Treasury bills, notes, and bonds? 363.201 Section 363.201 Money and Finance... Securities § 363.201 What other regulations govern book-entry marketable book-entry Treasury bills, notes...

  10. Encouraging Maternal Sacrifice: How Regulations Governing the Consumption of Pharmaceuticals During Pregnancy Prioritize Fetal Safety over Maternal Health and Autonomy.

    PubMed

    Donley, Greer

    Pregnant women are routinely faced with the stressful decision of whether to consume needed medications during their pregnancies. Because the risks associated with pharmaceutical drug consumption during pregnancy are largely unknown, pregnant women both inadvertently consume dangerous medications and avoid needed drugs. Both outcomes are harmful to pregnant women and their fetuses. This unparalleled lack of drug safety information is a result of ill-conceived, paternalistic regulations in two areas of the law: regulations governing ethical research in human subjects and regulations that dictate the required labels on drugs. The former categorizes pregnant women as "vulnerable" and thus precludes them from most medical research. The result is that ninety-one percent of drugs lack any reliable safety information for pregnant consumers. The latter currently requires all drug labels to encourage drug avoidance during pregnancy, despite ample evidence that avoiding needed medications can harm pregnant women. On June 30, 2015, new pregnancy labeling regulations took effect. Though these regulations make important improvements, they continue to treat pregnant women unlike any population, including other unique subpopulations, such as children. As a result, the new regulations do not fix the problem of over-warning pregnant women about the risks of drug consumption. This article questions the legitimacy of both regulations and suggests three reforms for how to improve access to vital safety information: (1) amend the regulations governing ethical research in human subjects to reclassify pregnant women as non-vulnerable adults; (2) create incentives to generate safety data in pregnant women by granting a period of market exclusivity for drug companies that invest in this research; and (3) make the FDA pregnancy labeling regulations consistent with the routine FDA practice of requiring the display of balanced, human data on risk.

  11. Governing through Prevent? Regulation and Contested Practice in State–Muslim Engagement

    PubMed Central

    O’Toole, Therese; Meer, Nasar; DeHanas, Daniel Nilsson; Jones, Stephen H; Modood, Tariq

    2016-01-01

    In this article, we consider the implications of the ‘Prevent’ strand of the government’s counter-terrorism strategy for the UK state’s engagement with Muslims. We argue that the logics of Prevent have been highly problematic for state–Muslim engagement. Nevertheless, we suggest that the characterisation of state approaches to engaging Muslims as a form of discipline is incomplete without an analysis of: first, differences in practices, habits and perspectives across governance domains; second, variations in approach and implementation between levels of governance; and third, the agency of Muslims who engage with the state. Through this approach we show how attention to the situated practices of governance reveals the contested nature of governing through Prevent. PMID:26877558

  12. 7 CFR 301.91-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE... without stopping except under normal traffic conditions such as traffic lights or stop signs) any...

  13. 7 CFR 301.91-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE... without stopping except under normal traffic conditions such as traffic lights or stop signs) any...

  14. 32 CFR 700.857 - Safe navigation and regulations governing operation of ships and aircraft.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND... Operations or the Commandant of the Marine Corps, as appropriate. (d) The Commanding Officer is responsible...

  15. 32 CFR 700.857 - Safe navigation and regulations governing operation of ships and aircraft.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND... Operations or the Commandant of the Marine Corps, as appropriate. (d) The Commanding Officer is responsible...

  16. 32 CFR 700.857 - Safe navigation and regulations governing operation of ships and aircraft.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) DEPARTMENT OF THE NAVY UNITED STATES NAVY REGULATIONS AND OFFICIAL RECORDS UNITED STATES NAVY REGULATIONS AND... Operations or the Commandant of the Marine Corps, as appropriate. (d) The Commanding Officer is responsible...

  17. [Governance and regulation in health: challenges for health management in Greater Metropolitan São Paulo, Brazil].

    PubMed

    Ibanhes, Lauro Cesar; Heimann, Luiza Sterman; Junqueira, Virginia; Boaretto, Roberta Cristina; Pessoto, Umberto Catarino; Cortizo, Carlos Tato; Castro, Iracema Ester do Nascimento; Rocha, Jucilene Leite da; Kayano, Jorge; Luiz, Olinda do Carmo; Barboza, Renato; Telesi, Emilio

    2007-03-01

    This paper discusses the relationship between the public and private sectors in the Unified National Health System (SUS), based on research whose objective was to identify governance strategies and mechanisms for public/private relations in the health sector, considering the search for equity in Greater Metropolitan Sao Paulo, Brazil. Governance was used as an analytical category, with health system regulation as the issue. Municipal and State health secretaries, members of health councils, and SUS staff were interviewed, and the empirical material was classified as: (a) regulatory mechanisms and instruments; (b) power loci; and (c) actors' positions concerning the SUS and its relationship to the private sector. Mechanisms and instruments have been created and used in the municipalities for regulation of their own services. Regulatory measures for the complementary and supplementary healthcare sector are practically nonexistent. There are numerous institutional power loci, seen more as places for submitting demands than as forums for negotiation. Despite some progress, governance appears to be more of a formal issue. Discussion is needed on the relationship between the public and private sectors and its regulation by municipalities in order to improve the health system.

  18. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in...

  19. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in the...

  20. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in the...

  1. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in the...

  2. 7 CFR 301.87-4 - Conditions governing the interstate movement of regulated articles from regulated areas in...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Sugarcane Diseases Quarantine and Regulations § 301.87... identity has been maintained, and it has not been used for the production of sugarcane while in the...

  3. Governing Education through Data in England: From Regulation to Self-Evaluation

    ERIC Educational Resources Information Center

    Ozga, Jenny

    2009-01-01

    This paper explores the relationship between changing forms of the governance of education and the growth and uses of data in the context of England--a context that can be described as the most "advanced" in Europe in terms of data production and use. The paper links the shifting relations between the central department of education…

  4. 76 FR 61597 - Grants and Cooperative Agreements to State and Local Governments: DOT Amendments on Regulations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-05

    ...-profit organization listed in 2 uniform cost accounting CFR part 230, Appendix C, as not standards that... organization or a Principles and Procedures, or non-profit organization listed in 2 uniform cost accounting CFR... agreements to State and Local governments. In addition, this rule updates references to applicable...

  5. 78 FR 30233 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ...)(C), and (vii)). 7. Covered Government Support Contractor Organizational Conflict of Interest Comment... regarding organizational conflicts of interest, observing that one part of a large defense contractor might...: Independently of this rule, the organizational conflict of interest rules restrict a support contractor...

  6. TEQSA and Risk-Based Regulation: Considerations for University Governing Bodies

    ERIC Educational Resources Information Center

    Baird, Jeanette

    2013-01-01

    The advent of a new national regulatory and quality assurance regime in Australia, through the Tertiary Education Quality and Standards Agency (TEQSA), presents additional requirements to university governing bodies, for compliance with standards and for risk management. This paper discusses TEQSA's approach and potential vulnerabilities for TEQSA…

  7. 76 FR 72914 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Government...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... Form 1637, Notice of Acceptance of Inventory Schedules; DD Form 1639, Scrap Warranty; DD Form 1640... following disposal determinations: (i) Downgrade useable property to scrap. (ii) Abandonment or destruction... schedules. (2) DD Form 1639, Scrap Warranty: When scrap is sold by the contractor, after Government approval...

  8. Governing Education through Data in England: From Regulation to Self-Evaluation

    ERIC Educational Resources Information Center

    Ozga, Jenny

    2009-01-01

    This paper explores the relationship between changing forms of the governance of education and the growth and uses of data in the context of England--a context that can be described as the most "advanced" in Europe in terms of data production and use. The paper links the shifting relations between the central department of education…

  9. Roll-Out Neoliberalism and Hybrid Practices of Regulation in Australian Agri-Environmental Governance

    ERIC Educational Resources Information Center

    Lockie, Stewart; Higgins, Vaughan

    2007-01-01

    In the last 15 years, agri-environmental programmes in Australia have been underpinned by a neoliberal regime of governing which seeks to foster participation and "bottom-up" change at the regional level at the same time as encouraging farmers to become entrepreneurial and improve their productivity and environmental performance without…

  10. 76 FR 11363 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-02

    ... prime contractors and other third parties, provided that the technical data owner may require the... Government support contractors to have access to proprietary technical data belonging to prime contractors...), provided that the contractor-- (1) Is not affiliated with the prime contractor or a first-tier...

  11. Degradation of sigma 32, the heat shock regulator in Escherichia coli, is governed by HflB.

    PubMed Central

    Herman, C; Thévenet, D; D'Ari, R; Bouloc, P

    1995-01-01

    The heat shock response in Escherichia coli is governed by the concentration of the highly unstable sigma factor sigma 32. The essential protein HflB (FtsH), known to control proteolysis of the phage lambda cII protein, also governs sigma 32 degradation: an HflB-depleted strain accumulated sigma 32 and induced the heat shock response, and the half-life of sigma 32 increased by a factor up to 12 in mutants with reduced HflB function and decreased by a factor of 1.8 in a strain overexpressing HflB. The hflB gene is in the ftsJ-hflB operon, one promoter of which is positively regulated by heat shock and sigma 32. The lambda cIII protein, which stabilizes sigma 32 and lambda cII, appears to inhibit the HflB-governed protease. The E. coli HflB protein controls the stability of two master regulators, lambda cII and sigma 32, responsible for the lysis-lysogeny decision of phage lambda and the heat shock response of the host. Images Fig. 2 Fig. 4 Fig. 5 PMID:7724592

  12. 77 FR 57055 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... as having a potential for tax avoidance or evasion (American Jobs Creation Act of 2004, Public Law... 230. These proposed regulations clarify that practitioners must exercise competence when engaged in... general competence standard is being proposed in new Sec. 10.35. The proposed regulations also clarify...

  13. 78 FR 33994 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-06

    ... Defense Acquisition Regulations System 48 CFR Part 252 RIN Number 0750-AG38 Defense Federal Acquisition... AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule; correction. SUMMARY: This document corrects the amendatory language to a final rule published in the Federal...

  14. State government regulation of forestry practices applied to nonfederal forests: extent and intensity of agency involvement

    Treesearch

    Paul V. Ellefson; Michael A. Kilgore; James E. Granskog

    2006-01-01

    In 2003, 276 state governmental agencies regulated forestry practices applied to nonfederal forests. Fifty-four percent of these agencies were moderately to extensively involved in such regulation, and 68% engaged in moderate to extensive regulatory coordination with a state's lead forestry agency. The agencies employed an estimates 1,047 full-time equivalents (...

  15. 75 FR 80426 - Defense Federal Acquisition Regulation Supplement; Reporting of Government-Furnished Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... Defense Acquisition Regulations System 48 CFR Parts 211, 212, and 252 Defense Federal Acquisition... System; Department of Defense (DoD). ] ACTION: Proposed rule with request for comments. SUMMARY: DoD...-602-0350. Mail: Defense Acquisition Regulations System, Attn: Ms. Mary Overstreet,...

  16. Regulations governing the issuance of certificates of airworthiness of aircraft in France

    NASA Technical Reports Server (NTRS)

    1923-01-01

    These regulations, approved by the Under Secretary of State for Aeronautics, in a ministerial decree 1124/2a, Feb. 19, 1923, cancels the regulations of Aug. 31, 1920, and supplements the decree of Aug. 14, 1920, fixing the conditions under which certificates of airworthiness may be issued,in conformity with Article 5 of said decree.

  17. Analysis of Provincial and Municipal Regulations Governing Crustacean Welfare in Italy.

    PubMed

    Liuzzo, Gaetano; Rossi, Roberto; Giacometti, Federica; Mescolini, Giulia; Piva, Silvia; Serraino, Andrea

    2017-01-24

    The trade in live crustaceans implies keeping these animals alive after capture and/or farming until purchase by the final consumer. Regarding animal welfare, the European Union includes cephalopods in Directive 2010/63/EU on the protection of animals used for scientific purposes, but there are no further regulations on crustaceans in EU legislation. The present study analysed the provisions of Italian municipal regulations on animal welfare applicable to crustaceans. Only 62 of the 110 municipal websites of the provincial capitals reported a regulation safeguarding animal welfare. These regulations contain different rules on: aquaria characteristics (size, volume and shape); management of aquaria; maintenance (preservation and exposure) of live aquatic species; slaughtering and/or suppression of aquatic species and crustaceans; tying of crustacean claws; and crustacean cooking. The analysis on Italian municipal regulations on crustaceans' animal welfare showed that the provisions are vague, lacking uniformity and scientific guidelines.

  18. Gene regulation is governed by a core network in hepatocellular carcinoma

    PubMed Central

    2012-01-01

    Background Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide, and the mechanisms that lead to the disease are still relatively unclear. However, with the development of high-throughput technologies it is possible to gain a systematic view of biological systems to enhance the understanding of the roles of genes associated with HCC. Thus, analysis of the mechanism of molecule interactions in the context of gene regulatory networks can reveal specific sub-networks that lead to the development of HCC. Results In this study, we aimed to identify the most important gene regulations that are dysfunctional in HCC generation. Our method for constructing gene regulatory network is based on predicted target interactions, experimentally-supported interactions, and co-expression model. Regulators in the network included both transcription factors and microRNAs to provide a complete view of gene regulation. Analysis of gene regulatory network revealed that gene regulation in HCC is highly modular, in which different sets of regulators take charge of specific biological processes. We found that microRNAs mainly control biological functions related to mitochondria and oxidative reduction, while transcription factors control immune responses, extracellular activity and the cell cycle. On the higher level of gene regulation, there exists a core network that organizes regulations between different modules and maintains the robustness of the whole network. There is direct experimental evidence for most of the regulators in the core gene regulatory network relating to HCC. We infer it is the central controller of gene regulation. Finally, we explored the influence of the core gene regulatory network on biological pathways. Conclusions Our analysis provides insights into the mechanism of transcriptional and post-transcriptional control in HCC. In particular, we highlight the importance of the core gene regulatory network; we propose that it is highly related to

  19. Federal Government's Proposed Expansion of Regulation of Biospecimen Research Should Be Reconsidered.

    PubMed

    Robertson, Christopher T; Loe, Jonathan D

    2016-10-01

    In September, the U.S. Department of Health and Human Services, together with other federal agencies, announced proposed changes to the rules governing human subjects research. This Commentary discusses how the proposals would affect research using biospecimens that is essential to the future success of precision medicine. We argue that the proposed changes unnecessarily burden such research, without meaningfully advancing the interests of donors. They should be revised before being finalized.

  20. 77 FR 7930 - Improving Government Regulations; Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... Regulatory Flexibility Analysis Required: Yes. Agency Contact: Ynette R. Shelkin, Editor, Defense Acquisition... Regulatory Flexibility Analysis Required: Yes. Agency Contact: Mary Overstreet, Department of Defense... Analysis Required: Yes. Agency Contact: Ynette R. Shelkin, Editor, Defense Acquisition Regulations System...

  1. 76 FR 81362 - Regulations Governing the Performance of Actuarial Services Under the Employee Retirement Income...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ... Enrollment of Actuaries. ACTION: Correction to final regulations. SUMMARY: This document contains corrections...) and (H),'' is corrected to read ``901.11(f)(2)(i)(D), 901.11(f)(2)(i)(G) and (H),''. Guy R. Traynor...

  2. 78 FR 73704 - Eagle Permits; Changes in the Regulations Governing Eagle Permitting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... review provision, we believe this final regulation strikes a good balance between providing that... programmatic permit would address. Response: An Avian Protection Plan (APP) is a voluntary good-faith effort to...

  3. Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction

    PubMed Central

    Laxmikanthan, Gurunathan; Xu, Chen; Brilot, Axel F; Warren, David; Steele, Lindsay; Seah, Nicole; Tong, Wenjun; Grigorieff, Nikolaus; Landy, Arthur; Van Duyne, Gregory D

    2016-01-01

    The molecular machinery responsible for DNA expression, recombination, and compaction has been difficult to visualize as functionally complete entities due to their combinatorial and structural complexity. We report here the structure of the intact functional assembly responsible for regulating and executing a site-specific DNA recombination reaction. The assembly is a 240-bp Holliday junction (HJ) bound specifically by 11 protein subunits. This higher-order complex is a key intermediate in the tightly regulated pathway for the excision of bacteriophage λ viral DNA out of the E. coli host chromosome, an extensively studied paradigmatic model system for the regulated rearrangement of DNA. Our results provide a structural basis for pre-existing data describing the excisive and integrative recombination pathways, and they help explain their regulation. DOI: http://dx.doi.org/10.7554/eLife.14313.001 PMID:27223329

  4. A Conserved Transcriptional Regulator Governs Fungal Morphology in Widely Diverged Species

    PubMed Central

    Cain, Christopher W.; Lohse, Matthew B.; Homann, Oliver R.; Sil, Anita; Johnson, Alexander D.

    2012-01-01

    Fungi exhibit a large variety of morphological forms. Here, we examine the functions of a deeply conserved regulator of morphology in three fungal species: Saccharomyces cerevisiae, Candida albicans, and Histoplasma capsulatum. We show that, despite an estimated 600 million years since those species diverged from a common ancestor, Wor1 in C. albicans, Ryp1 in H. capsulatum, and Mit1 in S. cerevisiae are transcriptional regulators that recognize the same DNA sequence. Previous work established that Wor1 regulates white–opaque switching in C. albicans and that its ortholog Ryp1 regulates the yeast to mycelial transition in H. capsulatum. Here we show that the ortholog Mit1 in S. cerevisiae is also a master regulator of a morphological transition, in this case pseudohyphal growth. Full-genome chromatin immunoprecipitation experiments show that Mit1 binds to the control regions of the previously known regulators of pseudohyphal growth as well as those of many additional genes. Through a comparison of binding sites for Mit1 in S. cerevisiae, Wor1 in C. albicans, and Wor1 ectopically expressed in S. cerevisiae, we conclude that the genes controlled by the orthologous regulators overlap only slightly between these two species despite the fact that the DNA binding specificity of the regulators has remained largely unchanged. We suggest that the ancestral Wor1/Mit1/Ryp1 protein controlled aspects of cell morphology and that movement of genes in and out of the Wor1/Mit1/Ryp1 regulon is responsible, in part, for the differences of morphological forms among these species. PMID:22095082

  5. [Deceased organ donors, legal regulations governing diagnosis of brain death, overview of donors and liver transplants in the Czech Republic].

    PubMed

    Pokorná, E

    2013-08-01

    The key restriction of transplantation medicine globally, as well as in the Czech Republic, concerns the lack of organs. The number of deceased donors, and thus the availability of organ transplants, has been stagnating in our country. The paper describes current legal regulations governing the dia-gnosis of brain death and primary legal and medical criteria for the contraindication of the deceased for organ explantation, gives an overview of the number of liver transplants, age structure, and diagnosis resulting in brain death of the deceased liver donors in the Czech Republic.

  6. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy

    PubMed Central

    Kim, Minah; Park, Hyeung Ju; Seol, Jae Won; Jang, Jeon Yeob; Cho, Young-Suk; Kim, Kyu Rae; Choi, Youngsok; Lydon, John P; DeMayo, Francesco J; Shibuya, Masabumi; Ferrara, Napoleone; Sung, Hoon-Ki; Nagy, Andras; Alitalo, Kari; Koh, Gou Young

    2013-01-01

    The features and regulation of uterine angiogenesis and vascular remodelling during pregnancy are poorly defined. Here we show that dynamic and variable decidual angiogenesis (sprouting, intussusception and networking), and active vigorous vascular remodelling such as enlargement and elongation of ‘vascular sinus folding’ (VSF) and mural cell drop-out occur distinctly in a spatiotemporal manner in the rapidly growing mouse uterus during early pregnancy — just after implantation but before placentation. Decidual angiogenesis is mainly regulated through VEGF-A secreted from the progesterone receptor (PR)-expressing decidual stromal cells which are largely distributed in the anti-mesometrial region (AMR). In comparison, P4-PR-regulated VEGF-A-VEGFR2 signalling, ligand-independent VEGFR3 signalling and uterine natural killer (uNK) cells positively and coordinately regulate enlargement and elongation of VSF. During the postpartum period, Tie2 signalling could be involved in vascular maturation at the endometrium in a ligand-independent manner, with marked reduction of VEGF-A, VEGFR2 and PR expressions. Overall, we show that two key vascular growth factor receptors — VEGFR2 and Tie2 — strikingly but differentially regulate decidual angiogenesis and vascular remodelling in rapidly growing and regressing uteri in an organotypic manner. PMID:23853117

  7. A Network of Local and Redundant Gene Regulation Governs Arabidopsis Seed Maturation

    PubMed Central

    To, Alexandra; Valon, Christiane; Savino, Gil; Guilleminot, Jocelyne; Devic, Martine; Giraudat, Jérôme; Parcy, François

    2006-01-01

    In Arabidopsis thaliana, four major regulators (ABSCISIC ACID INSENSITIVE3 [ABI3], FUSCA3 [FUS3], LEAFY COTYLEDON1 [LEC1], and LEC2) control most aspects of seed maturation, such as accumulation of storage compounds, cotyledon identity, acquisition of desiccation tolerance, and dormancy. The molecular basis for complex genetic interactions among these regulators is poorly understood. By analyzing ABI3 and FUS3 expression in various single, double, and triple maturation mutants, we have identified multiple regulatory links among all four genes. We found that one of the major roles of LEC2 was to upregulate FUS3 and ABI3. The lec2 mutation is responsible for a dramatic decrease in ABI3 and FUS3 expression, and most lec2 phenotypes can be rescued by ABI3 or FUS3 constitutive expression. In addition, ABI3 and FUS3 positively regulate themselves and each other, thereby forming feedback loops essential for their sustained and uniform expression in the embryo. Finally, LEC1 also positively regulates ABI3 and FUS3 in the cotyledons. Most of the genetic controls discovered were found to be local and redundant, explaining why they had previously been overlooked. This works establishes a genetic framework for seed maturation, organizing the key regulators of this process into a hierarchical network. In addition, it offers a molecular explanation for the puzzling variable features of lec2 mutant embryos. PMID:16731585

  8. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... or common law with the force and effect of law which enables the Tribe or Tribal organization to... 45 Public Welfare 2 2010-10-01 2010-10-01 false What governing Tribal law or regulations must a... ENFORCEMENT (IV-D) PROGRAM Tribal IV-D Plan Requirements § 309.90 What governing Tribal law or...

  9. Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.

    PubMed

    Teramoto, Takayuki; Lambie, Eric J; Iwasaki, Kouichi

    2005-05-01

    The transient receptor potential (TRP) channels are implicated in various cellular processes, including sensory signal transduction and electrolyte homeostasis. We show here that the GTL-1 and GON-2 TRPM channels regulate electrolyte homeostasis in the C. elegans intestine. GON-2 is responsible for a large outwardly rectifying current of intestinal cells, and its activity is tightly regulated by intracellular Mg(2+) levels, while GTL-1 mainly contributes to appropriate Mg(2+) responsiveness of the outwardly rectifying current. We also used nickel cytotoxicity to study the function of these channels. Both GON-2 and GTL-1 are necessary for intestinal uptake of nickel, but GTL-1 is continuously active while GON-2 is inactivated at higher Mg(2+) levels. This type of differential regulation of intestinal electrolyte absorption ensures a constant supply of electrolytes through GTL-1, while occasional bursts of GON-2 activity allow rapid return to normal electrolyte concentrations following physiological perturbations.

  10. 75 FR 51713 - Regulations Governing Practice Before the Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... comprehensive set of recommendations to ensure uniform and high ethical standards of conduct for all tax return... proposed regulations also do not alter or supplant ethical standards that might otherwise be applicable to..., two hours of tax- related ethics and 10 hours of Federal tax law topics. The registration year is...

  11. 76 FR 29665 - Migratory Bird Permits; Changes in the Regulations Governing Raptor Propagation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... reorganize the current regulations, and add or change some provisions therein. The changes make it easier to understand the requirements for raptor propagation, make it simpler to conduct raptor propagation, and... propagation of golden eagles, though we may consider allowing it in the future. DATES: This rule is effective...

  12. 7 CFR 999.400 - Regulation governing the importation of filberts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... sanitary regulations of city, county, State or Federal agencies. (g) Compliance. Any person who violates... clean; (2) Free from foreign material, mold, rancidity, decay or insect injury; and (3) Free from... firm and crisp, not containing more than 6 percent moisture. (2) Clean means practically free from...

  13. 7 CFR 999.400 - Regulation governing the importation of filberts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... sanitary regulations of city, county, State or Federal agencies. (g) Compliance. Any person who violates... clean; (2) Free from foreign material, mold, rancidity, decay or insect injury; and (3) Free from... firm and crisp, not containing more than 6 percent moisture. (2) Clean means practically free from...

  14. 7 CFR 999.400 - Regulation governing the importation of filberts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... sanitary regulations of city, county, State or Federal agencies. (g) Compliance. Any person who violates... clean; (2) Free from foreign material, mold, rancidity, decay or insect injury; and (3) Free from... firm and crisp, not containing more than 6 percent moisture. (2) Clean means practically free from...

  15. 7 CFR 999.400 - Regulation governing the importation of filberts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... sanitary regulations of city, county, State or Federal agencies. (g) Compliance. Any person who violates... clean; (2) Free from foreign material, mold, rancidity, decay or insect injury; and (3) Free from... firm and crisp, not containing more than 6 percent moisture. (2) Clean means practically free from...

  16. 7 CFR 999.400 - Regulation governing the importation of filberts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... other business unit. (5) USDA inspector means a Federal or Federal-State inspector, Food Safety and... section do not supersede the Federal Plant Quarantine Act of 1912, the Federal Food, Drug, and Cosmetic Act, or any other applicable laws or regulations or the need to comply with applicable food...

  17. 78 FR 44237 - Improving Government Regulations; Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... (DFARS Case 2011-D044). 120 Release of Fundamental 0750-AH92 Research Information (DFARS Case 2012-D054....quinones@osd.mi.l RIN: 0750-AH58 120. Release of Fundamental Research Information (DFARS Case 2012-D054... Acquisition Regulation Supplement (DFARS) to provide guidance relating to the release of fundamental...

  18. RULES AND REGULATIONS TO GOVERN THE ADMINISTRATION AND OPERATION OF SPECIAL EDUCATION.

    ERIC Educational Resources Information Center

    Illinois State Office of the Superintendent of Public Instruction, Springfield.

    RULES AND REGULATIONS FOR SPECIAL EDUCATION PROGRAMS IN ILLINOIS ARE REVIEWED. AREAS OF SPECIAL EDUCATION TREATED SEPARATELY INCLUDE PHYSICALLY HANDICAPPED CHILDREN IN SPECIAL CLASSROOMS, PHYSICALLY HANDICAPPED CHILDREN IN HOME AND HOSPITAL, DEAF AND HARD OF HEARING, BLIND, PARTIALLY SEEING, MALADJUSTED CHILDREN, EDUCABLE MENTALLY HANDICAPPED,…

  19. 17 CFR 230.161 - Amendments to rules and regulations governing exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Amendments to rules and... EXCHANGE COMMISSION GENERAL RULES AND REGULATIONS, SECURITIES ACT OF 1933 General § 230.161 Amendments to... securities under section 3(b) of the Act, as in effect at the time the securities are first bona fide...

  20. Regulations Governing Special Education Programs for Children with Disabilities in Virginia (Effective January 1994).

    ERIC Educational Resources Information Center

    Virginia State Dept. of Education, Richmond. Div. of Compliance Coordination.

    The Virginia regulations for special education have been designed to comply with the Individuals with Disabilities Education Act, Section 504 of the Rehabilitation Act of 1973, the Americans with Disabilities Act, and the Virginians with Disabilities Act. Part 1 presents definitions of 80 terms. Part 2 considers responsibilities and functions of…

  1. 75 FR 1525 - Walnuts Grown in California; Changes to Regulations Governing Voting Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... / Tuesday, January 12, 2010 / Rules and Regulations#0;#0; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing... ``Act.'' The Department of Agriculture (USDA) is issuing this rule in conformance with Executive Order... reserving meeting spaces, may also be reduced. This final rule expands the procedures currently prescribed...

  2. Older smokers could be the strongest supporters for U.S. government regulation of tobacco: a focus group study

    PubMed Central

    2013-01-01

    Background Targeting of marginalized groups with aggressive tobacco marketing has been identified as exacerbating health disparities. However, interpretation of such targeting by groups varies, from surprise and outrage to regarding such marketing as evidence of social legitimacy. We sought to learn how an often-overlooked marginalized group, older adults, would respond to industry documents offering evidence of tobacco company target marketing. Methods We conducted 10 focus groups in California cities with older (≥50 years) smokers and former smokers. A set of previously-undisclosed tobacco industry documents related to target marketing was shown to the group in sequence. Audiotaped discussions were transcribed and data analyzed using qualitative approaches. Results Responses to evidence of tobacco industry targeting varied, with some regarding it as exploitive and others as normal business practice. However, in most groups, discussions turned to government’s failure to protect the public—even though government action /inaction was not prompted nor addressed in the discussion documents. Conclusion Given the Food and Drug Administration’s new authority to regulate tobacco products, these findings suggest that some of the tobacco industry’s “best customers” (older, established smokers and ex-smokers) may be strong supporters of government regulation of tobacco. PMID:23958397

  3. Off-licence prescribing and regulation in psychiatry: current challenges require a new model of governance

    PubMed Central

    Sugarman, Philip; Mitchell, Amy; Frogley, Catherine; Dickens, Geoffrey L

    2013-01-01

    The growing worldwide use of pharmaceuticals is managed in some countries by a regulatory system which sharply divides legal use into licensed and unlicensed categories. We examine how for the range of psychotropics this simultaneously restricts the possible benefits to patients, prescribers and producers in some domains, while failing to manage the risks in others. A more flexible system, which shares at an earlier stage experience and evidence on benefits and risks in patients, previously marginalized on the grounds of age, diagnosis or comorbidity, would aid the development of safer, more effective ‘real-world prescribing’. Practical recommendations are made for a new model of research and prescribing governance, to enable more effective repurposing of these treatments. PMID:24167695

  4. 77 FR 66568 - Revisions to Procedural Regulations Governing Transportation by Intrastate Pipelines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... intrastate pipelines. \\1\\ 18 CFR 284.123. \\2\\ 15 U.S.C. 3372. \\3\\ Section 1(c) of the NGA exempts from the...-3432; 42 U.S.C. 7101-7352; 43 U.S.C. 1331-1356. 2. Section 284.123 is amended by adding paragraphs (g... operating conditions pursuant to Sec. 284.123 of the Commission's regulations.\\1\\ Section 284.123 applies...

  5. Signaling, transcriptional regulation, and asynchronous pattern formation governing plant xylem development

    PubMed Central

    FUKUDA, Hiroo

    2016-01-01

    In plants, vascular stem cells continue to give rise to all xylem and phloem cells, which constitute the plant vascular system. During plant vascular development, the peptide, tracheary element differentiation inhibitory factor (TDIF), regulates vascular stem cell fate in a non-cell-autonomous fashion. TDIF promotes vascular stem cell proliferation through up-regulating the transcription factor gene WUS-related HOMEOBOX4, and it suppresses xylem differentiation from vascular stem cells through the activation of Glycogen Synthase Kinase 3 proteins. VASCULAR-RELATED NAC-DOMAIN6 and 7 (VND6 and 7) are master transcription factors, and ectopic expression of VND6 and VND7 in various plants induces differentiation of different types of cells into metaxylem and protoxylem tracheary elements, respectively. These genes up-regulate genes involved in both patterned secondary cell wall formation and programmed cell death to form tracheary elements. Secondary wall patterns are formed by localized deposition of cellulose microfibrils, which is guided by cortical microtubules. Local activation of the small G-protein, Rho-type 11 determines distribution of cortical microtubules. PMID:26972600

  6. Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging

    PubMed Central

    de Lucia, Chiara; Murphy, Tytus; Thuret, Sandrine

    2017-01-01

    Aging alters cellular and molecular processes, including those of stem cells biology. In particular, changes in neural stem cells (NSCs) are linked to cognitive decline associated with aging. Recently, the systemic environment has been shown to alter both NSCs regulation and age-related cognitive decline. Interestingly, a well-documented and naturally occurring way of altering the composition of the systemic environment is through diet and nutrition. Furthermore, it is well established that the presence of specific nutrients as well as the overall increase or reduction of calorie intake can modulate conserved molecular pathways and respectively reduce or increase lifespan. In this review, we examine these pathways in relation to their function on NSCs and cognitive aging. We highlight the importance of the Sirtuin, mTOR and Insulin/Insulin like growth factor-1 pathways as well as the significant role played by epigenetics in the dietary regulation of NSCs and the need for further research to exploit nutrition as a mode of intervention to regulate NSCs aging. PMID:28194114

  7. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

    PubMed

    Arda, H Efsun; Li, Lingyu; Tsai, Jennifer; Torre, Eduardo A; Rosli, Yenny; Peiris, Heshan; Spitale, Robert C; Dai, Chunhua; Gu, Xueying; Qu, Kun; Wang, Pei; Wang, Jing; Grompe, Markus; Scharfmann, Raphael; Snyder, Michael S; Bottino, Rita; Powers, Alvin C; Chang, Howard Y; Kim, Seung K

    2016-05-10

    Intensive efforts are focused on identifying regulators of human pancreatic islet cell growth and maturation to accelerate development of therapies for diabetes. After birth, islet cell growth and function are dynamically regulated; however, establishing these age-dependent changes in humans has been challenging. Here, we describe a multimodal strategy for isolating pancreatic endocrine and exocrine cells from children and adults to identify age-dependent gene expression and chromatin changes on a genomic scale. These profiles revealed distinct proliferative and functional states of islet α cells or β cells and histone modifications underlying age-dependent gene expression changes. Expression of SIX2 and SIX3, transcription factors without prior known functions in the pancreas and linked to fasting hyperglycemia risk, increased with age specifically in human islet β cells. SIX2 and SIX3 were sufficient to enhance insulin content or secretion in immature β cells. Our work provides a unique resource to study human-specific regulators of islet cell maturation and function. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Does government regulation inhibit embryonic stem cell research and can it be effective?

    PubMed

    Winston, R M L

    2007-06-07

    The UK was one of the first countries to introduce legislation regulating embryo research, and the British Parliament has taken a liberal view of the field. However, even in the UK, regulation of human embryonic stem cell (ESC) research has had drawbacks, and the regulatory framework is somewhat inconsistent and imposes considerable bureaucracy. There are around 33 countries that have broadly liberal legislation; each has a different view of what is permissible. Only about eight of these countries have contributed significantly to published research in the field. Paradoxically, in spite of tight federal restrictions, the USA remains the most productive country in terms of the number and quality of peer review research publications. But even in our increasingly global society, complex regulation will become progressively irrelevant and impossible to impose effectively because attitudes will continue to vary widely in different countries and because of international travel and trade. Consequently, there is a universal need for scientists to demonstrate their recognition of the ethical and commercial conflicts that may arise in their research and engage in public debate and dialogue to ensure responsible activity that benefits their research and reflects the values of society.

  9. An analysis of potential barriers and enablers to regulating the television marketing of unhealthy foods to children at the state government level in Australia.

    PubMed

    Chung, Alexandra; Shill, Jane; Swinburn, Boyd; Mavoa, Helen; Lawrence, Mark; Loff, Bebe; Crammond, Bradley; Sacks, Gary; Allender, Steven; Peeters, Anna

    2012-12-28

    In Australia there have been many calls for government action to halt the effects of unhealthy food marketing on children's health, yet implementation has not occurred. The attitudes of those involved in the policy-making process towards regulatory intervention governing unhealthy food marketing are not well understood. The objective of this research was to understand the perceptions of senior representatives from Australian state and territory governments, statutory authorities and non-government organisations regarding the feasibility of state-level government regulation of television marketing of unhealthy food to children in Australia. Data from in-depth semi-structured interviews with senior representatives from state and territory government departments, statutory authorities and non-government organisations (n=22) were analysed to determine participants' views about regulation of television marketing of unhealthy food to children at the state government level. Data were analysed using content and thematic analyses. Regulation of television marketing of unhealthy food to children was supported as a strategy for obesity prevention. Barriers to implementing regulation at the state level were: the perception that regulation of television advertising is a Commonwealth, not state/territory, responsibility; the power of the food industry and; the need for clear evidence that demonstrates the effectiveness of regulation. Evidence of community support for regulation was also cited as an important factor in determining feasibility. The regulation of unhealthy food marketing to children is perceived to be a feasible strategy for obesity prevention however barriers to implementation at the state level exist. Those involved in state-level policy making generally indicated a preference for Commonwealth-led regulation. This research suggests that implementation of regulation of the television marketing of unhealthy food to children should ideally occur under the direction

  10. An analysis of potential barriers and enablers to regulating the television marketing of unhealthy foods to children at the state government level in Australia

    PubMed Central

    2012-01-01

    Background In Australia there have been many calls for government action to halt the effects of unhealthy food marketing on children's health, yet implementation has not occurred. The attitudes of those involved in the policy-making process towards regulatory intervention governing unhealthy food marketing are not well understood. The objective of this research was to understand the perceptions of senior representatives from Australian state and territory governments, statutory authorities and non-government organisations regarding the feasibility of state-level government regulation of television marketing of unhealthy food to children in Australia. Method Data from in-depth semi-structured interviews with senior representatives from state and territory government departments, statutory authorities and non-government organisations (n=22) were analysed to determine participants' views about regulation of television marketing of unhealthy food to children at the state government level. Data were analysed using content and thematic analyses. Results Regulation of television marketing of unhealthy food to children was supported as a strategy for obesity prevention. Barriers to implementing regulation at the state level were: the perception that regulation of television advertising is a Commonwealth, not state/territory, responsibility; the power of the food industry and; the need for clear evidence that demonstrates the effectiveness of regulation. Evidence of community support for regulation was also cited as an important factor in determining feasibility. Conclusions The regulation of unhealthy food marketing to children is perceived to be a feasible strategy for obesity prevention however barriers to implementation at the state level exist. Those involved in state-level policy making generally indicated a preference for Commonwealth-led regulation. This research suggests that implementation of regulation of the television marketing of unhealthy food to children

  11. Reliability of a rating procedure to monitor industry self-regulation codes governing alcohol advertising content.

    PubMed

    Babor, Thomas F; Xuan, Ziming; Proctor, Dwayne

    2008-03-01

    The purposes of this study were to develop reliable procedures to monitor the content of alcohol advertisements broadcast on television and in other media, and to detect violations of the content guidelines of the alcohol industry's self-regulation codes. A set of rating-scale items was developed to measure the content guidelines of the 1997 version of the U.S. Beer Institute Code. Six focus groups were conducted with 60 college students to evaluate the face validity of the items and the feasibility of the procedure. A test-retest reliability study was then conducted with 74 participants, who rated five alcohol advertisements on two occasions separated by 1 week. Average correlations across all advertisements using three reliability statistics (r, rho, and kappa) were almost all statistically significant and the kappas were good for most items, which indicated high test-retest agreement. We also found high interrater reliabilities (intraclass correlations) among raters for item-level and guideline-level violations, indicating that regardless of the specific item, raters were consistent in their general evaluations of the advertisements. Naïve (untrained) raters can provide consistent (reliable) ratings of the main content guidelines proposed in the U.S. Beer Institute Code. The rating procedure may have future applications for monitoring compliance with industry self-regulation codes and for conducting research on the ways in which alcohol advertisements are perceived by young adults and other vulnerable populations.

  12. CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice

    PubMed Central

    Shimokawa, Noriaki; Haglund, Kaisa; Hölter, Sabine M; Grabbe, Caroline; Kirkin, Vladimir; Koibuchi, Noriyuki; Schultz, Christian; Rozman, Jan; Hoeller, Daniela; Qiu, Chun-Hong; Londoño, Marina B; Ikezawa, Jun; Jedlicka, Peter; Stein, Birgit; Schwarzacher, Stephan W; Wolfer, David P; Ehrhardt, Nicole; Heuchel, Rainer; Nezis, Ioannis; Brech, Andreas; Schmidt, Mirko H H; Fuchs, Helmut; Gailus-Durner, Valerie; Klingenspor, Martin; Bogler, Oliver; Wurst, Wolfgang; Deller, Thomas; de Angelis, Martin Hrabé; Dikic, Ivan

    2010-01-01

    Despite extensive investigations of Cbl-interacting protein of 85 kDa (CIN85) in receptor trafficking and cytoskeletal dynamics, little is known about its functions in vivo. Here, we report the study of a mouse deficient of the two CIN85 isoforms expressed in the central nervous system, exposing a function of CIN85 in dopamine receptor endocytosis. Mice lacking CIN85 exon 2 (CIN85Δex2) show hyperactivity phenotypes, characterized by increased physical activity and exploratory behaviour. Interestingly, CIN85Δex2 animals display abnormally high levels of dopamine and D2 dopamine receptors (D2DRs) in the striatum, an important centre for the coordination of animal behaviour. Importantly, CIN85 localizes to the post-synaptic compartment of striatal neurons in which it co-clusters with D2DRs. Moreover, it interacts with endocytic regulators such as dynamin and endophilins in the striatum. Absence of striatal CIN85 causes insufficient complex formation of endophilins with D2DRs in the striatum and ultimately decreased D2DR endocytosis in striatal neurons in response to dopamine stimulation. These findings indicate an important function of CIN85 in the regulation of dopamine receptor functions and provide a molecular explanation for the hyperactive behaviour of CIN85Δex2 mice. PMID:20551902

  13. Risk for anxiety and implications for treatment: developmental, environmental, and genetic factors governing fear regulation

    PubMed Central

    Hartley, Catherine A.; Casey, BJ

    2013-01-01

    Anxiety disorders are the most common of the psychiatric disorders affecting as many as 10% of youth, with a peak during adolescence. A core component of these disorders is an unremitting fear in the absence of present threat. One of the most commonly used therapies to treat these disorders is exposure-based cognitive behavioral therapy that identifies the source of the fear and anxiety and then desensitizes the individual to it. This treatment builds on basic principles of fear extinction learning. A number of patients improve with this therapy, but 40–50% do not. This paper provides an overview of recent empirical studies employing both human imaging and cross-species behavioral genetics to examine how fear regulation varies across individuals and across development, especially during adolescence. These studies have important implications for understanding who may be at risk for anxiety disorders and for whom and when during development exposure-based therapies may be most effective. PMID:24147742

  14. TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment

    PubMed Central

    Li, Yun; Luikart, Bryan W.; Birnbaum, Shari; Chen, Jian; Kwon, Chang-Hyuk; Kernie, Steven G.; Bassel-Duby, Rhonda; Parada, Luis F.

    2008-01-01

    Summary Adult hippocampal neurogenesis is stimulated by chronic administration of antidepressants (ADs) and by voluntary exercise. Neural progenitor cells in the dentate gyrus (DG) that are capable of continuous proliferation and neuronal differentiation are the source of such structural plasticity. Here we report that mice lacking the receptor tyrosine kinase TrkB in hippocampal NPCs have impaired proliferation and neurogenesis. When exposed to chronic AD or wheel running, no increase in proliferation or neurogenesis is observed. Ablation of TrkB also renders these mice behaviorally insensitive to antidepressive treatment in depression and anxiety-like paradigms. In contrast, mice lacking TrkB only in differentiated DG neurons display typical neurogenesis and respond normally to chronic AD. Thus, our data establish an essential cell autonomous role for TrkB in regulating hippocampal neurogenesis, behavioral sensitivity to antidepressive treatments, and support the notion that impairment of the neurogenic niche is an etiological factor for refractory responses to antidepressive regimen. PMID:18701066

  15. Alternative Splicing Governs Cone Cyclic Nucleotide-gated (CNG) Channel Sensitivity to Regulation by Phosphoinositides*

    PubMed Central

    Dai, Gucan; Sherpa, Tshering; Varnum, Michael D.

    2014-01-01

    Precursor mRNA encoding CNGA3 subunits of cone photoreceptor cyclic nucleotide-gated (CNG) channels undergoes alternative splicing, generating isoforms differing in the N-terminal cytoplasmic region of the protein. In humans, four variants arise from alternative splicing, but the functional significance of these changes has been a persistent mystery. Heterologous expression of the four possible CNGA3 isoforms alone or with CNGB3 subunits did not reveal significant differences in basic channel properties. However, inclusion of optional exon 3, with or without optional exon 5, produced heteromeric CNGA3 + CNGB3 channels exhibiting an ∼2-fold greater shift in K1/2,cGMP after phosphatidylinositol 4,5-biphosphate or phosphatidylinositol 3,4,5-trisphosphate application compared with channels lacking the sequence encoded by exon 3. We have previously identified two structural features within CNGA3 that support phosphoinositides (PIPn) regulation of cone CNG channels: N- and C-terminal regulatory modules. Specific mutations within these regions eliminated PIPn sensitivity of CNGA3 + CNGB3 channels. The exon 3 variant enhanced the component of PIPn regulation that depends on the C-terminal region rather than the nearby N-terminal region, consistent with an allosteric effect on PIPn sensitivity because of altered N-C coupling. Alternative splicing of CNGA3 occurs in multiple species, although the exact variants are not conserved across CNGA3 orthologs. Optional exon 3 appears to be unique to humans, even compared with other primates. In parallel, we found that a specific splice variant of canine CNGA3 removes a region of the protein that is necessary for high sensitivity to PIPn. CNGA3 alternative splicing may have evolved, in part, to tune the interactions between cone CNG channels and membrane-bound phosphoinositides. PMID:24675082

  16. [Methodology of injury compensation and Government Regulation of injury compensation in reflection in the Constitutional Court decision].

    PubMed

    Žďárek, Roman

    2017-01-01

    After the new Civil Code had come into force, the Compensation Statute lost the efficiency. The injury compensation should not have been provided according medical report with respect to the Compensation Statute but according decency basis. So the Highest Court has accepted the Methodology of compensation. The article deals with the first reflection of the Methodology in the judicature of the Constitutional Court as well as the opinion of the Constitutional Court of the Government Statute which regulates the injury compensation in labour law. The Metodology of compensation is based on the ICF (International Classification of Functioning, Disability and Health), while the Compensation Statute was based on the etiology principe. ICF is a classification of health and health-related domains. As the functioning and disability of an individual occurs in a context, ICF also includes a list of environmental factors. ICF is the WHO framework for measuring health and disability at both individual and population levels.

  17. Government Regulatory

    NASA Astrophysics Data System (ADS)

    Becker, Katie

    Government regulation of food products, food processing, and food preparation is imperative in bringing an unadulterated, nonmisleading, and safe food product to market and is relevant to all areas of food science, including engineering, processing, chemistry, and microbiology. The liability associated with providing consumers with an adulterated or substandard product cannot only tarnish a company's name and reputation, but also impose substantial financial repercussions on the company and those individuals who play an active role in the violation. In order for a company to fully comply with the relevant food laws (both federal and state), an intimate knowledge of food science is required. Individuals knowledgeable in food science play an integral role not only in implementing and counseling food companies/processors to ensure compliance with government regulations, but these individuals are also necessary to the state and federal governments that make and enforce the relevant laws and regulators.

  18. Incentives and regulations to reconcile conservation and development: thirty years of governance of the Sami pastoral ecosystem in Finnmark, Norway.

    PubMed

    Ulvevadet, Birgitte; Hausner, Vera H

    2011-10-01

    Incentive-based mechanisms are regarded as efficient instruments to reconcile conservation and development. This win-win objective has been difficult to accomplish; cross-compliance has, therefore, been suggested as a mechanism to ensure sustainability. Cross-compliance, which requires producers to conform to production regulations and environmental standards to qualify for direct payments, has been a popular instrument in the Common Agricultural Policy (CAP) reform. Since 1990, cross-compliance has been the main characteristic of policy design in Sami reindeer husbandry in Finnmark, Norway. All direct transfers to the Sami pastoralists have been connected to harvesting demands to decrease the number of reindeer and to conserve pastures. The content of these incentive-based mechanisms are decided through negotiated agreements with the Sami Reindeer Herders' Association of Norway (NRL), and the regulation of reindeer numbers and access to pastures are delegated to co-management boards. Despite the participation of the Sami pastoralists in shaping these policies, win-win objectives have not been achieved. Although the cross-compliance program could have been improved by payment for graded results, the lack of regulations by the administration or co-management boards is more likely to be the cause of failure to reach sustainability. Despite the long-term failures of the cross-compliance program, policies have been slow to change. We might attribute this delay to the NRL's strong position in the negotiated agreements. In general, we argue that the success of the cross-compliance program depends on a well-functioning governance system that can implement regulations and sanctions if incentives do not work as intended.

  19. Glycolysis Is Governed by Growth Regime and Simple Enzyme Regulation in Adherent MDCK Cells

    PubMed Central

    Rehberg, Markus; Ritter, Joachim B.; Reichl, Udo

    2014-01-01

    Due to its vital importance in the supply of cellular pathways with energy and precursors, glycolysis has been studied for several decades regarding its capacity and regulation. For a systems-level understanding of the Madin-Darby canine kidney (MDCK) cell metabolism, we couple a segregated cell growth model published earlier with a structured model of glycolysis, which is based on relatively simple kinetics for enzymatic reactions of glycolysis, to explain the pathway dynamics under various cultivation conditions. The structured model takes into account in vitro enzyme activities, and links glycolysis with pentose phosphate pathway and glycogenesis. Using a single parameterization, metabolite pool dynamics during cell cultivation, glucose limitation and glucose pulse experiments can be consistently reproduced by considering the cultivation history of the cells. Growth phase-dependent glucose uptake together with cell-specific volume changes generate high intracellular metabolite pools and flux rates to satisfy the cellular demand during growth. Under glucose limitation, the coordinated control of glycolytic enzymes re-adjusts the glycolytic flux to prevent the depletion of glycolytic intermediates. Finally, the model's predictive power supports the design of more efficient bioprocesses. PMID:25329309

  20. Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme Activation*

    PubMed Central

    Batra, Jyotica; Szabó, András; Caulfield, Thomas R.; Soares, Alexei S.; Sahin-Tóth, Miklós; Radisky, Evette S.

    2013-01-01

    Human chymotrypsin C (CTRC) is a pancreatic serine protease that regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. In cleaving these regulatory sites, which are characterized by multiple flanking acidic residues, CTRC shows substrate specificity that is distinct from that of other isoforms of chymotrypsin and elastase. Here, we report the first crystal structure of active CTRC, determined at 1.9-Å resolution, revealing the structural basis for binding specificity. The structure shows human CTRC bound to the small protein protease inhibitor eglin c, which binds in a substrate-like manner filling the S6-S5′ subsites of the substrate binding cleft. Significant binding affinity derives from burial of preferred hydrophobic residues at the P1, P4, and P2′ positions of CTRC, although acidic P2′ residues can also be accommodated by formation of an interfacial salt bridge. Acidic residues may also be specifically accommodated in the P6 position. The most unique structural feature of CTRC is a ring of intense positive electrostatic surface potential surrounding the primarily hydrophobic substrate binding site. Our results indicate that long-range electrostatic attraction toward substrates of concentrated negative charge governs substrate discrimination, which explains CTRC selectivity in regulating active digestive enzyme levels. PMID:23430245

  1. Government regulation of forestry practices on private forest land in the United States: an assessment of state government responsibilities and program performance

    Treesearch

    Paul V. Ellefson; Michael A. Kilgore; James E. Granskog

    2006-01-01

    In 2003, a comprehensive assessment of state government, forest practice regulatory programs in the United States was undertaken. Involved was an extensive review of the literature and information gathering h m program administration in all 50 states. The assessment determined that regulatory programs focus on a wide range of forestry practices applied to private...

  2. SpoIIE governs the phosphorylation state of a protein regulating transcription factor sigma F during sporulation in Bacillus subtilis.

    PubMed Central

    Arigoni, F; Duncan, L; Alper, S; Losick, R; Stragier, P

    1996-01-01

    Cell-specific activation of the transcription factor sigma F during sporulation in Bacillus subtilis is controlled by a regulatory pathway involving the proteins SpoIIE, SpoIIAA, and SpoIIAB. SpoIIAB is an antagonist of sigma F, and SpoIIAA, which is capable of overcoming SpoIIAB-mediated inhibition of sigma F, is an antagonist of SpoIIAB. SpoIIAA is, in turn, negatively regulated by SpoIIAB, which phosphorylates SpoIIAA on serine 58. SpoIIAA is also positively regulated by SpoIIE, which dephosphorylates SpoIIAA-P, the phosphorylated form of SpoIIAA. Here, isoelectric focusing and Western blot analysis were used to examine the phosphorylation state of SpoIIAA in vivo. SpoIIAA was found to be largely in the phosphorylated state during sporulation in wild-type cells but a significant portion of the protein that was unphosphorylated could also be detected. Consistent with the idea that SpoIIE governs dephosphorylation of SpoIIAA-P, SpoIIAA was entirely in the phosphorylated state in spoIIE mutant cells. Conversely, overexpression of spoIIE led to an increase in the ratio of unphosphorylated SpoIIAA to SpoIIAA-P and caused inappropriate activation of sigma F in the predivisional sporangium. We also show that a mutant form of SpoIIAA (SpoIIAA-S58T) in which serine 58 was replaced with threonine was present exclusively as SpoIIAA-P, a finding that confirms previous biochemical evidence that the mutant protein is an effective substrate for the SpoIIAB kinase but that SpoIIAA-S58T-P cannot be dephosphorylated by SpoIIE. We conclude that SpoIIE plays a crucial role in controlling the phosphorylation state of SpoIIAA during sporulation and thus in governing the cell-specific activation of sigma F. Images Fig. 1 Fig. 2 Fig. 4 PMID:8622920

  3. M.I.T. and the Federal Government. An Examination of the Effects of Government Regulation and Research Support on Selected Parts of M.I.T.

    ERIC Educational Resources Information Center

    Garvin, David

    A self-study was undertaken at the Massachusetts Institute of Technology (M.I.T.) to examine the impact of the federal government on it. M.I.T. is a large institution with an enrollment of 8,000, a faculty of 950, and a total teaching staff of 1,700. Of its operating expenses by far the largest source of funds in recent years has been sponsored…

  4. Government regulation of pricing and reimbursement of prescription medicines: results of a recent multi-country review.

    PubMed

    Kingham, Richard; Wheeler, Joanna

    2009-01-01

    Access to prescription medicines is an essential component of publicly funded or publicly assisted healthcare programs. Thus, important policy questions are presented when government agencies that administer those programs establish procedures for making decisions about the appropriate use of medicines, including determinations as to which medicines will be reimbursed, at what prices, and for which patients. The authors reviewed systems for making determinations on pricing and reimbursement of prescription medicines under public healthcare systems in 10 countries, including four member states of the European Union (EU) (France, Germany, Italy and the United Kingdom), plus Australia, Brazil, China, India, Japan and Korea. In addition to national regulatory requirements, the authors considered international agreements that may impose obligations with respect to procedures for pricing and reimbursement of prescription medicines, including the EU's Transparency Directive, agreements administered by the World Trade Organization (WTO), and bilateral free trade agreements negotiated by the United States in recent years. Drawing on this experience, the authors sought to identify common themes, pitfalls and best practices in national systems for regulating pricing and reimbursement of prescription medicines. The authors have focused primarily on procedures, rather than the underlying political assumptions or substantive economic objectives. They have assumed that all countries have--or should have--a common interest in assuring that decision-making procedures afford interested persons who have relevant information a meaningful opportunity to participate

  5. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... experimental or scientific purposes; or (ii) The regulated article originates outside the quarantined area and... regulated articles from quarantined areas. 301.86-4 Section 301.86-4 Agriculture Regulations of the... regulated articles from quarantined areas. (a) Any regulated article may be moved interstate from...

  6. 7 CFR 301.51-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... experimental or scientific purposes; or (ii) The regulated article originates outside the quarantined area and... regulated articles from quarantined areas. 301.51-4 Section 301.51-4 Agriculture Regulations of the... of regulated articles from quarantined areas. (a) Any regulated article may be moved interstate...

  7. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other articles...

  8. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other articles...

  9. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other articles...

  10. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other articles...

  11. 7 CFR 301.53-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES Emerald Ash Borer § 301.53-4 Conditions governing the interstate movement of... infestation by emerald ash borer; and (iv) The article has not been combined or commingled with other articles...

  12. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pale Cyst Nematode § 301.86-4 Conditions governing the interstate movement of...

  13. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pale Cyst Nematode § 301.86-4 Conditions governing the interstate movement of...

  14. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pale Cyst Nematode § 301.86-4 Conditions governing the interstate movement of...

  15. 7 CFR 301.86-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pale Cyst Nematode § 301.86-4 Conditions governing the interstate movement of...

  16. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Hass avocado fruit that has fallen from the trees may not be included in field boxes of fruit to be... until moved. (iii) Hass avocados must be protected from fruit fly infestations during their movement... DOMESTIC QUARANTINE NOTICES Fruit Flies § 301.32-4 Conditions governing the interstate movement of...

  17. 75 FR 54527 - Defense Federal Acquisition Regulation Supplement; Government Rights in the Design of DoD Vessels...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... 2009 and the Vessel Hull Design Protection Amendments of 2008. Section 825 clarifies the Government's rights in technical data in the designs of a DoD vessel, boat, craft, or components thereof. DATES... Authorization Act for Fiscal Year 2009 (Pub. L. 110- 417) and the Vessel Hull Design Protection Amendments of...

  18. The Evolving Contingency Contracting Market: Private Sector Self regulation and United States Government Monitoring of Procurement of Stability Operations Services

    DTIC Science & Technology

    2016-01-01

    tingency environment ( declared and non- declared ), including military operations, stability operations, natural disasters, humanitarian, and other...well as how contracting firms may offer institutional memory and operational impartiality that might be difficult for government employees to offer...in a contingency environ- ment ( declared and non- declared ), including military operations, stability operations, natural disasters, humanitarian, and

  19. 49 CFR 350.341 - What specific variances from the FMCSRs are allowed for State laws and regulations governing...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... intrastate commerce and not subject to Federal jurisdiction? 350.341 Section 350.341 Transportation Other... governing motor carriers, CMV drivers, and CMVs engaged in intrastate commerce and not subject to Federal... commerce, provided that neither the GVW, GVWR, GCW, nor GCWR of the vehicle equals or exceeds 11,801 kg...

  20. Designing the Framework Conditions for Assuring Academic Standards: Lessons Learned about Professional, Market, and Government Regulation of Academic Quality

    ERIC Educational Resources Information Center

    Dill, David D.; Beerkens, Maarja

    2013-01-01

    The new demands of mass systems of higher education and the emerging environment of global academic competition are altering the traditional institutions for assuring academic standards in universities. As a consequence many nations are experimenting with new instruments for academic quality assurance. Contemporary government control of academic…

  1. Designing the Framework Conditions for Assuring Academic Standards: Lessons Learned about Professional, Market, and Government Regulation of Academic Quality

    ERIC Educational Resources Information Center

    Dill, David D.; Beerkens, Maarja

    2013-01-01

    The new demands of mass systems of higher education and the emerging environment of global academic competition are altering the traditional institutions for assuring academic standards in universities. As a consequence many nations are experimenting with new instruments for academic quality assurance. Contemporary government control of academic…

  2. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  3. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  4. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  5. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  6. 7 CFR 301.55-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DOMESTIC QUARANTINE NOTICES South American Cactus Moth § 301.55-4 Conditions governing the interstate... woven cloth) adequate to prevent access by South American cactus moths while moving through the... woven cloth) adequate to prevent access by South American cactus moths while within the quarantined...

  7. United States Government Accountability Office report on nanotechnology: nanomaterials are widely used in commerce, but EPA faces challenges in regulating risk.

    PubMed

    2010-01-01

    Nanotechnology involves the ability to control matter at the scale of a nanometer--one billionth of a meter. The world market for products that contain nanomaterials is expected to reach $2.6 trillion by 2015. In this context, the United States Government Accountability Office (GAO): (1) identified examples of current and potential uses of nanomaterials, (2) determined what is known about the potential human health and environmental risks from nanomaterials, (3) assessed actions the Environmental Protection Agency (EPA) has taken to better understand and regulate the risks posed by nanomaterials as well as its authorities to do so, and (4) identified approaches that other selected national authorities and U.S. states have taken to address the potential risks associated with nanomaterials. The GAO analyzed selected laws and regulations, reviewed information on the EPA's Nanoscale Materials Stewardship Program, and consulted with EPA officials and legal experts to obtain their perspectives on the EPA's authorities to regulate nanomaterials.

  8. Regulation to create environments conducive to physical activity: understanding the barriers and facilitators at the Australian state government level.

    PubMed

    Shill, Jane; Mavoa, Helen; Crammond, Brad; Loff, Bebe; Peeters, Anna; Lawrence, Mark; Allender, Steven; Sacks, Gary; Swinburn, Boyd A

    2012-01-01

    Policy and regulatory interventions aimed at creating environments more conducive to physical activity (PA) are an important component of strategies to improve population levels of PA. However, many potentially effective policies are not being broadly implemented. This study sought to identify potential policy/regulatory interventions targeting PA environments, and barriers/facilitators to their implementation at the Australian state/territory government level. In-depth interviews were conducted with senior representatives from state/territory governments, statutory authorities and non-government organisations (n = 40) to examine participants': 1) suggestions for regulatory interventions to create environments more conducive to PA; 2) support for preselected regulatory interventions derived from a literature review. Thematic and constant comparative analyses were conducted. POLICY INTERVENTIONS MOST COMMONLY SUGGESTED BY PARTICIPANTS FELL INTO TWO AREAS: 1) urban planning and provision of infrastructure to promote active travel; 2) discouraging the use of private motorised vehicles. Of the eleven preselected interventions presented to participants, interventions relating to walkability/cycling and PA facilities received greatest support. Interventions involving subsidisation (of public transport, PA-equipment) and the provision of more public transport infrastructure received least support. These were perceived as not economically viable or unlikely to increase PA levels. Dominant barriers were: the powerful 'road lobby', weaknesses in the planning system and the cost of potential interventions. Facilitators were: the provision of evidence, collaboration across sectors, and synergies with climate change/environment agendas. This study points to how difficult it will be to achieve policy change when there is a powerful 'road lobby' and government investment prioritises road infrastructure over PA-promoting infrastructure. It highlights the pivotal role of the

  9. Regulation to Create Environments Conducive to Physical Activity: Understanding the Barriers and Facilitators at the Australian State Government Level

    PubMed Central

    Shill, Jane; Mavoa, Helen; Crammond, Brad; Loff, Bebe; Peeters, Anna; Lawrence, Mark; Allender, Steven; Sacks, Gary; Swinburn, Boyd A.

    2012-01-01

    Introduction Policy and regulatory interventions aimed at creating environments more conducive to physical activity (PA) are an important component of strategies to improve population levels of PA. However, many potentially effective policies are not being broadly implemented. This study sought to identify potential policy/regulatory interventions targeting PA environments, and barriers/facilitators to their implementation at the Australian state/territory government level. Methods In-depth interviews were conducted with senior representatives from state/territory governments, statutory authorities and non-government organisations (n = 40) to examine participants': 1) suggestions for regulatory interventions to create environments more conducive to PA; 2) support for preselected regulatory interventions derived from a literature review. Thematic and constant comparative analyses were conducted. Results Policy interventions most commonly suggested by participants fell into two areas: 1) urban planning and provision of infrastructure to promote active travel; 2) discouraging the use of private motorised vehicles. Of the eleven preselected interventions presented to participants, interventions relating to walkability/cycling and PA facilities received greatest support. Interventions involving subsidisation (of public transport, PA-equipment) and the provision of more public transport infrastructure received least support. These were perceived as not economically viable or unlikely to increase PA levels. Dominant barriers were: the powerful ‘road lobby’, weaknesses in the planning system and the cost of potential interventions. Facilitators were: the provision of evidence, collaboration across sectors, and synergies with climate change/environment agendas. Conclusion This study points to how difficult it will be to achieve policy change when there is a powerful ‘road lobby’ and government investment prioritises road infrastructure over PA

  10. Tough but True: School Board Neglect of Bus Safety Led to Government's Overblown, Under-Researched Regulations.

    ERIC Educational Resources Information Center

    American School Board Journal, 1978

    1978-01-01

    The apparent lack of concern school boards evidenced in the past over school bus safety has precipitated the National Highway Traffic Safety Administration regulations that have angered board members and bus manufacturers alike. It is argued that the new regulations are not based on research. (Author/IRT)

  11. Arabidopsis VASCULAR-RELATED NAC-DOMAIN6 directly regulates the genes that govern programmed cell death and secondary wall formation during xylem differentiation.

    PubMed

    Ohashi-Ito, Kyoko; Oda, Yoshihisa; Fukuda, Hiroo

    2010-10-01

    Xylem consists of three types of cells: tracheary elements (TEs), parenchyma cells, and fiber cells. TE differentiation includes two essential processes, programmed cell death (PCD) and secondary cell wall formation. These two processes are tightly coupled. However, little is known about the molecular mechanisms underlying these processes. Here, we show that VASCULAR-RELATED NAC-DOMAIN6 (VND6), a master regulator of TEs, regulates some of the downstream genes involved in these processes in a coordinated manner. We first identified genes that are expressed downstream of VND6 but not downstream of SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN1 (SND1), a master regulator of xylem fiber cells, using transformed suspension culture cells in microarray experiments. We found that VND6 and SND1 governed distinct aspects of xylem formation, whereas they regulated a number of genes in common, specifically those related to secondary cell wall formation. Genes involved in TE-specific PCD were upregulated only by VND6. Moreover, we revealed that VND6 directly regulated genes that harbor a TE-specific cis-element, TERE, in their promoters. Thus, we found that VND6 is a direct regulator of genes related to PCD as well as to secondary wall formation.

  12. Have government regulations improved workplace safety? A test of the asynchronous regulatory effects in China's coal industry, 1995-2006

    SciTech Connect

    Shi, X.P.

    2009-07-01

    Empirical studies on the effectiveness of workplace safety regulations are inconclusive. This study hypothesizes that the asynchronous effects of safety regulations occur because regulations need time to become effective. Safety regulations will work initially by reducing the most serious accidents, and later by improving overall safety performance. The hypothesis is tested by studying a provincial level aggregate panel dataset for China's coal industry using two different models with different sets of dependent variables: a fixed-effects model on mortality rate, which is defined as fatalities per 1,000 employees; and a negative binominal model on the annual number (frequency) of disastrous accidents. Safety regulations can reduce the frequency of disastrous accidents, but have not reduced mortality rate, which represents overall safety performance. Policy recommendations are made, including shifting production from small to large mines through industrial consolidation, improving the safety performance of large mines, addressing consequences of decentralization, and facilitating the implementation of regulations through carrying on institutional actions and supporting legislation.

  13. Spatial Phosphoprotein Profiling Reveals a Compartmentalized Extracellular Signal-regulated Kinase Switch Governing Neurite Growth and Retraction

    SciTech Connect

    Wang, Yingchun; Yang, Feng; Fu, Yi; Huang, Xiahe; Wang, Wei; Jiang, Xining; Gritsenko, Marina A.; Zhao, Rui; Monroe, Matthew E.; Pertz, Olivier C.; Purvine, Samuel O.; Orton, Daniel J.; Jacobs, Jon M.; Camp, David G.; Smith, Richard D.; Klemke, Richard L.

    2011-05-20

    Abstract - Brain development and spinal cord regeneration require neurite sprouting and growth cone navigation in response to extension and collapsing factors present in the extracellular environment. These external guidance cues control neurite growth cone extension and retraction processes through intracellular protein phosphorylation of numerous cytoskeletal, adhesion, and polarity complex signaling proteins. However, the complex kinase/substrate signaling networks that mediate neuritogenesis have not been investigated. Here, we compare the neurite phosphoproteome under growth and retraction conditions using neurite purification methodology combined with mass spectrometry. More than 4000 non-redundant phosphorylation sites from 1883 proteins have been annotated and mapped to signaling pathways that control kinase/phosphatase networks, cytoskeleton remodeling, and axon/dendrite specification. Comprehensive informatics and functional studies revealed a compartmentalized ERK activation/deactivation cytoskeletal switch that governs neurite growth and retraction, respectively. Our findings provide the first system-wide analysis of the phosphoprotein signaling networks that enable neurite growth and retraction and reveal an important molecular switch that governs neuritogenesis.

  14. 7 CFR 301.85-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 2

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... samples for processing, testing, or analysis may be moved interstate from any quarantined State under the..., testing or analysis may be moved interstate from any regulated area only to laboratories approved 3 by the...

  15. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... samples for processing, testing, or analysis, may be moved interstate from any quarantined State under the... been maintained, and they have been safeguarded against infestation while in the regulated area in...

  16. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... samples for processing, testing, or analysis, may be moved interstate from any quarantined State under the... been maintained, and they have been safeguarded against infestation while in the regulated area in...

  17. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... samples for processing, testing, or analysis, may be moved interstate from any quarantined State under the... been maintained, and they have been safeguarded against infestation while in the regulated area in...

  18. 7 CFR 301.80-3 - Conditions governing the interstate movement of regulated articles from quarantined States. 3

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... samples for processing, testing, or analysis, may be moved interstate from any quarantined State under the... been maintained, and they have been safeguarded against infestation while in the regulated area in...

  19. 7 CFR 301.32-4 - Conditions governing the interstate movement of regulated articles from quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... domestic plant quarantines and regulations must also be met. (a) With a certificate or limited permit... area quarantined for Mexican or sapote fruit fly and that are moving interstate from such an area...

  20. Recent government regulations in the United States seek to ensure the effectiveness of antibiotics by limiting their agricultural use.

    PubMed

    Centner, Terence J

    2016-09-01

    The development of bacteria resistant to antibiotics is viewed as a medical health threat. Because thousands of people die every year due to antibiotic-resistant bacteria, efforts are underway to reduce antibiotic usage which in turn will reduce the development of antibiotic-resistant bacteria. In the United States, the use of antibiotics in the production of food animals to enhance animal growth has been identified as contributing to resistance. In 2015, a veterinary feed directive was adopted by the U.S. federal government prohibiting nontherapeutic uses of antibiotics in food animals that should reduce usage. The continued usage of antibiotics by producers for preventing disease may mean the directive is insufficient to reduce nontherapeutic antibiotic administration. This may lead some consumers to seek meat products from animals raised without antibiotics. A governmentally-sponsored labeling program could encourage reduction in antibiotic usage.

  1. The Government's role in regulating, coordinating, and standardizing the response to Alzheimer's disease: Anticipated international cooperation in the area of intractable and rare diseases.

    PubMed

    Tang, Qi; Song, Peipei; Xu, Lingzhong

    2016-11-01

    The World Health Organization (WHO) has emphasized that aging of the population is inextricably linked to many other global public health issues, such as universal health coverage, non-communicable diseases, and disability. However, Alzheimer's Disease International (ADI) estimates that 46.8 million elderly people worldwide were living with dementia in 2015. Alzheimer's disease (AD), the most common form of dementia, is one of the most common neurodegenerative diseases and is the main cause of cognitive impairment. AD will affect 5-7 out of every 100 older adults who are age 60 years or over. In response to the serious challenge posed by AD, governments are expected to play an important role in the prevention, diagnosis, and treatment of AD. As specific examples, i) the Japanese Government has instituted and supported regulations to encourage the development of AD drugs in order to accelerate research and development of innovative drugs; ii) the United States Government has cooperated with multiple partners such as non-governmental organizations in the response to AD; iii) Chinese governmental measures have standardized clinical diagnosis and treatment as part of the response to AD, including eligible patients, diagnostic criteria, therapeutic schedules, drug selection, and required inspections; iv) with political support from member governments, the European Union has issued guidelines and conducted clinical studies on medicines for the treatment of AD in order to ascertain the various stages of the disease and the relevance of biomarkers. AD is an intractable disease, so different countries need to share clinic trial information and cooperate in the conduct of those trials. International cooperation will play a key role in the response to other intractable and rare diseases.

  2. The Government's role in regulating, coordinating, and standardizing the response to Alzheimer's disease: Anticipated international cooperation in the area of intractable and rare diseases

    PubMed Central

    Tang, Qi; Song, Peipei; Xu, Lingzhong

    2016-01-01

    Summary The World Health Organization (WHO) has emphasized that aging of the population is inextricably linked to many other global public health issues, such as universal health coverage, non-communicable diseases, and disability. However, Alzheimer's Disease International (ADI) estimates that 46.8 million elderly people worldwide were living with dementia in 2015. Alzheimer's disease (AD), the most common form of dementia, is one of the most common neurodegenerative diseases and is the main cause of cognitive impairment. AD will affect 5–7 out of every 100 older adults who are age 60 years or over. In response to the serious challenge posed by AD, governments are expected to play an important role in the prevention, diagnosis, and treatment of AD. As specific examples, i) the Japanese Government has instituted and supported regulations to encourage the development of AD drugs in order to accelerate research and development of innovative drugs; ii) the United States Government has cooperated with multiple partners such as non-governmental organizations in the response to AD; iii) Chinese governmental measures have standardized clinical diagnosis and treatment as part of the response to AD, including eligible patients, diagnostic criteria, therapeutic schedules, drug selection, and required inspections; iv) with political support from member governments, the European Union has issued guidelines and conducted clinical studies on medicines for the treatment of AD in order to ascertain the various stages of the disease and the relevance of biomarkers. AD is an intractable disease, so different countries need to share clinic trial information and cooperate in the conduct of those trials. International cooperation will play a key role in the response to other intractable and rare diseases. PMID:27904818

  3. Quorum-sensing regulation governs bacterial adhesion, biofilm development, and host colonization in Pantoea stewartii subspecies stewartii

    PubMed Central

    Koutsoudis, Maria D.; Tsaltas, Dimitrios; Minogue, Timothy D.; von Bodman, Susanne B.

    2006-01-01

    The phytopathogenic bacterium Pantoea stewartii subsp. stewartii synthesizes stewartan exo/capsular polysaccharide (EPS) in a cell density-dependent manner governed by the EsaI/EsaR quorum-sensing (QS) system. This study analyzes biofilm development and host colonization of the WT and QS regulatory mutant strains of P. stewartii. First, we show that the cell density-dependent synthesis of stewartan EPS, governed by the EsaI/EsaR QS system, is required for proper bacterial adhesion and development of spatially defined, 3D biofilms. Second, a nonvirulent mutant lacking the esaI gene adheres strongly to surfaces and develops densely packed, less structurally defined biofilms in vitro. This strain appears to be arrested in a low cell density developmental mode. Exposure of this strain to exogenous N-acyl-homoserine lactone counteracts this adhesion phenotype. Third, QS mutants lacking the EsaR repressor attach poorly to surfaces and form amorphous biofilms heavily enmeshed in excess EPS. Fourth, the WT strain disseminates efficiently within the xylem, primarily in a basipetal direction. In contrast, the two QS mutant strains remain largely localized at the site of infection. Fifth, and most significantly, epifluorescence microscopic imaging of infected leaf tissue and excised xylem vessels reveals that the bacteria colonize the xylem with unexpected specificity, particularly toward the annular rings and spiral secondary wall thickenings of protoxylem, as opposed to indiscriminate growth to fill the xylem lumen. These observations are significant to bacterial plant pathogenesis in general and may reveal targets for disease control. PMID:16585516

  4. Government Publications.

    ERIC Educational Resources Information Center

    Whitlatch, Jo Bell

    1979-01-01

    Reviews recent federal publications on government information, particularly in the area of general informational services, public access to government information and privacy issues, coordination of government information systems, and congressional information needs. (Author)

  5. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  6. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  7. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  8. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government-to-government... Military Sales 225.7303-3 Government-to-government agreements. If a government-to-government agreement between the United States and a foreign government for the sale, coproduction, or cooperative...

  9. A dynamically changing intracellular water network serves as a universal regulator of the cell: the water-governed cycle.

    PubMed

    Szolnoki, Zoltán

    2007-06-01

    The functioning of enzymes and protein folding are well known to be assisted by the surrounding chaperoning water molecules, which are connected to the protein via non-covalent, dynamically changing chemical bonds. A molecular intracellular network of weak non-covalent connections may be presumed to exist in living cells. The roles of such non-covalent networks are examined in terms of a molecular model which postulates a universal enzyme and biochemical mechanism regulating the maintenance of chemical stability in living cells.

  10. A Kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene Cyp27b1 essential for vitamin D3 activation.

    PubMed

    Meyer, Mark B; Benkusky, Nancy A; Kaufmann, Martin; Lee, Seong Min; Onal, Melda; Jones, Glenville; Pike, J Wesley

    2017-08-14

    The vitamin D endocrine system regulates mineral homeostasis through its activities in the intestine, kidney, and bone. Terminal activation of vitamin D3 to its hormonal form, 1,25(OH)2D3, occurs in the kidney via the cytochrome P450 enzyme CYP27B1. Despite its importance in vitamin D metabolism, the molecular mechanisms underlying the regulation of the gene for this enzyme, Cyp27b1, are unknown. Here, we identified a kidney-specific control module governed by a renal cell-specific chromatin structure located distal to Cyp27b1 that mediates unique basal and parathyroid hormone (PTH)-, fibroblast growth factor 23 (FGF23)-, and 1,25(OH)2D3-mediated regulation of Cyp27b1 expression. Selective genomic deletion of key components within this module in mice resulted in loss of either PTH induction or FGF23 and 1,25(OH)2D3 suppression of Cyp27b1 gene expression; the former loss caused a debilitating skeletal phenotype, whereas the latter conferred a quasi-normal bone mineral phenotype through compensatory homeostatic mechanisms involving Cyp24a1 We found that Cyp27b1 is also expressed at low levels in non-renal cells, in which transcription was modulated exclusively by local factors via a process that was unaffected by deletion of the kidney-specific module. These results reveal that differential regulation of Cyp27b1 expression represents a mechanism whereby 1,25(OH)2D3 can fulfill separate functional roles: first in the kidney to control mineral homeostasis and second in extra-renal cells to regulate target genes linked to specific biological responses. Furthermore, we conclude that these mouse models open new avenues for the study of vitamin D metabolism and its involvement in therapeutic strategies for human health and disease. Copyright © 2017, The American Society for Biochemistry and Molecular Biology.

  11. REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation

    PubMed Central

    Garcia-Manteiga, Jose M.; Bonfiglio, Silvia; Folladori, Lucrezia; Malosio, Maria L.; Lazarevic, Dejan; Stupka, Elia; Cittaro, Davide; Meldolesi, Jacopo

    2015-01-01

    The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes, mostly based on indirect criteria, and demonstration of their operative dependence on the repressor have been established for only a relatively small fraction. In the present study, starting from our recently published work, we have expanded the identification of REST-dependent genes, investigated in two clones of the PC12 line, a recognized neuronal cell model, spontaneously expressing different levels of REST: very low as in neurons and much higher as in most non-neural cells. The molecular, structural and functional differences of the two PC12 clones were shown to depend largely on their different REST level and the ensuing variable expression of some dependent genes. Comprehensive RNA-Seq analyses of the 13,700 genes expressed, validated by parallel RT-PCR and western analyses of mRNAs and encoded proteins, identified in the high-REST clone two groups of almost 900 repressed and up-regulated genes. Repression is often due to direct binding of REST to target genes; up-regulation to indirect mechanism(s) mostly mediated by REST repression of repressive transcription factors. Most, but not all, genes governing neurosecretion, excitability, and receptor channel signaling were repressed in the high REST clone. The genes governing expression of non-channel receptors (G protein-coupled and others), although variably affected, were often up-regulated together with the genes of intracellular kinases, small G proteins, cytoskeleton, cell adhesion, and extracellular matrix proteins. Expression of REST-dependent genes governing functions other than those mentioned so far were also identified. The results obtained by the parallel investigation of the two PC12 clones revealed the complexity of the REST molecular and

  12. REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation.

    PubMed

    Garcia-Manteiga, Jose M; Bonfiglio, Silvia; Folladori, Lucrezia; Malosio, Maria L; Lazarevic, Dejan; Stupka, Elia; Cittaro, Davide; Meldolesi, Jacopo

    2015-01-01

    The role of REST changes in neurons, including the rapid decrease of its level during differentiation and its fluctuations during many mature functions and diseases, is well established. However, identification of many thousand possible REST-target genes, mostly based on indirect criteria, and demonstration of their operative dependence on the repressor have been established for only a relatively small fraction. In the present study, starting from our recently published work, we have expanded the identification of REST-dependent genes, investigated in two clones of the PC12 line, a recognized neuronal cell model, spontaneously expressing different levels of REST: very low as in neurons and much higher as in most non-neural cells. The molecular, structural and functional differences of the two PC12 clones were shown to depend largely on their different REST level and the ensuing variable expression of some dependent genes. Comprehensive RNA-Seq analyses of the 13,700 genes expressed, validated by parallel RT-PCR and western analyses of mRNAs and encoded proteins, identified in the high-REST clone two groups of almost 900 repressed and up-regulated genes. Repression is often due to direct binding of REST to target genes; up-regulation to indirect mechanism(s) mostly mediated by REST repression of repressive transcription factors. Most, but not all, genes governing neurosecretion, excitability, and receptor channel signaling were repressed in the high REST clone. The genes governing expression of non-channel receptors (G protein-coupled and others), although variably affected, were often up-regulated together with the genes of intracellular kinases, small G proteins, cytoskeleton, cell adhesion, and extracellular matrix proteins. Expression of REST-dependent genes governing functions other than those mentioned so far were also identified. The results obtained by the parallel investigation of the two PC12 clones revealed the complexity of the REST molecular and

  13. Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity

    PubMed Central

    Lambert, Nevin A.; Johnston, Christopher A.; Cappell, Steven D.; Kuravi, Sudhakiranmayi; Kimple, Adam J.; Willard, Francis S.; Siderovski, David P.

    2010-01-01

    G-protein heterotrimers, composed of a guanine nucleotide-binding Gα subunit and an obligate Gβγ dimer, regulate signal transduction pathways by cycling between GDP- and GTP-bound states. Signal deactivation is achieved by Gα-mediated GTP hydrolysis (GTPase activity) which is enhanced by the GTPase-accelerating protein (GAP) activity of “regulator of G-protein signaling” (RGS) proteins. In a cellular context, RGS proteins have also been shown to speed up the onset of signaling, and to accelerate deactivation without changing amplitude or sensitivity of the signal. This latter paradoxical activity has been variably attributed to GAP/enzymatic or non-GAP/scaffolding functions of these proteins. Here, we validated and exploited a Gα switch-region point mutation, known to engender increased GTPase activity, to mimic in cis the GAP function of RGS proteins. While the transition-state, GDP·AlF4 −-bound conformation of the G202A mutant was found to be nearly identical to wild-type, Gαi1(G202A)·GDP assumed a divergent conformation more closely resembling the GDP·AlF4 −-bound state. When placed within Saccharomyces cerevisiae Gα subunit Gpa1, the fast-hydrolysis mutation restored appropriate dose–response behaviors to pheromone signaling in the absence of RGS-mediated GAP activity. A bioluminescence resonance energy transfer (BRET) readout of heterotrimer activation with high temporal resolution revealed that fast intrinsic GTPase activity could recapitulate in cis the kinetic sharpening (increased onset and deactivation rates) and blunting of sensitivity also engendered by RGS protein action in trans. Thus Gα-directed GAP activity, the first biochemical function ascribed to RGS proteins, is sufficient to explain the activation kinetics and agonist sensitivity observed from G-protein–coupled receptor (GPCR) signaling in a cellular context. PMID:20351284

  14. Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration.

    PubMed

    Yi, Cong; Tong, Jingjing; Lu, Puzhong; Wang, Yizheng; Zhang, Jinxie; Sun, Chen; Yuan, Kangning; Xue, Renyu; Zou, Bing; Li, Nianzhong; Xiao, Shuhua; Dai, Chong; Huang, Yuwei; Xu, Liling; Li, Lin; Chen, She; Miao, Di; Deng, Haiteng; Li, Hongliang; Yu, Li

    2017-04-10

    Autophagy is essential for maintaining glucose homeostasis, but the mechanism by which energy deprivation activates autophagy is not fully understood. We show that Mec1/ATR, a member of the DNA damage response pathway, is essential for glucose starvation-induced autophagy. Mec1, Atg13, Atg1, and the energy-sensing kinase Snf1 are recruited to mitochondria shortly after glucose starvation. Mec1 is recruited through the adaptor protein Ggc1. Snf1 phosphorylates Mec1 on the mitochondrial surface, leading to recruitment of Atg1 to mitochondria. Furthermore, the Snf1-mediated Mec1 phosphorylation and mitochondrial recruitment of Atg1 are essential for maintaining mitochondrial respiration during glucose starvation, and active mitochondrial respiration is required for energy deprivation-activated autophagy. Thus, formation of a Snf1-Mec1-Atg1 module on mitochondria governs energy deprivation-induced autophagy by regulating mitochondrial respiration.

  15. Adapting to extreme events related to natural variability and climate change: the imperative of coupling technology with strong regulation and governance.

    PubMed

    Kythreotis, A P; Mercer, T G; Frostick, L E

    2013-09-03

    In recent years there has been an increase in extreme events related to natural variability (such as earthquakes, tsunamis and hurricanes) and climate change (such as flooding and more extreme weather). Developing innovative technologies is crucial in making society more resilient to such events. However, little emphasis has been placed on the role of human decision-making in maximizing the positive impacts of technological developments. This is exacerbated by the lack of appropriate adaptation options and the privatization of existing infrastructure, which can leave people exposed to increasing risk. This work examines the need for more robust government regulation and legislation to complement developments and innovations in technology in order to protect communities against such extreme events.

  16. What governs governance, and how does it evolve? The sociology of governance-in-action.

    PubMed

    Fox, Nick J; Ward, Katie J

    2008-09-01

    Governance addresses a wide range of issues including social, economic and political continuity, security and integrity, individual and collective safety and the liberty and rights to self-actualization of citizens. Questions to be answered include how governance can be achieved and sustained within a social context imbued with cultural values and in which power is distributed unevenly and dynamically, and how governance impacts on individuals and institutions. Drawing on Gramscian notions of hegemony and consent, and recent political science literatures on regulation and meta-regulation, this paper develops a sociological model of governance that emphasizes a dynamic and responsive governance in action. Empirical data from a study of pharmaceutical governance is used to show how multiple institutions and actors are involved in sustaining effective governance. The model addresses issues of how governance is sustained in the face of change, why governance of practices varies from setting to setting, and how governance is achieved without legislation.

  17. Regulation of Endothelial Glutathione by ICAM-1 governs VEGF-A mediated eNOS Activity and Angiogenesis

    PubMed Central

    Langston, Will; Chidlow, John H.; Booth, Blake A.; Barlow, Shayne C.; Lefer, David J.; Patel, Rakesh P.; Kevil, Christopher G.

    2007-01-01

    Previous studies suggest that inflammatory cell adhesion molecules may modulate endothelial cell migration and angiogenesis through unknown mechanisms. Using a combination of in vitro and in vivo approaches, herein we reveal a novel redox sensitive mechanism by which ICAM-1 modulates endothelial GSH that controls VEGF-A induced eNOS activity, endothelial chemotaxis, and angiogenesis. In vivo disk angiogenesis assays showed attenuated VEGF-A mediated angiogenesis in ICAM-1−/− mice. Moreover, VEGF-A dependent chemotaxis, eNOS phosphorylation, and nitric oxide (NO) production were impaired in ICAM-1−/− MAEC compared to WT MAEC. Decreasing intracellular GSH in ICAM-1−/− MAEC to levels observed in WT MAEC with 150 μM buthionine sulfoximine (BSO) restored VEGF-A responses. Conversely, GSH supplementation of WT MAEC with 5 mM glutathione ethyl ester (GEE) mimicked defects observed in ICAM-1−/− cells. Deficient angiogenic responses in ICAM-1−/− cells were associated with increased expression of the lipid phosphatase, PTEN, consistent with antagonism of signaling pathways leading to eNOS activation. PTEN expression was also sensitive to GSH status, decreasing or increasing in proportion to intracellular GSH concentrations. These data suggest a novel role for ICAM-1 in modulating VEGF-A induced angiogenesis and eNOS activity through regulation of PTEN expression via modulation of intracellular GSH status. PMID:17291995

  18. ESTABLISHING FINAL END STATE FOR A RETIRED NUCLEAR WEAPONS PRODUCTION REACTOR; COLLABORATION BETWEEN STAKEHOLDERS, REGULATORS AND THE FEDERAL GOVERNMENT

    SciTech Connect

    Bergren, C

    2009-01-16

    The Savannah River Site (SRS) is a 310-square-mile United States Department of Energy nuclear facility located along the Savannah River (SRS) near Aiken, South Carolina. Nuclear weapons material production began in the early 1950s, utilizing five production reactors. In the early 1990s all SRS production reactor operations were terminated. The first reactor closure end state declaration was recently institutionalized in a Comprehensive Environmental Response and Compensation and Liability Act (CERCLA) Early Action Record of Decision. The decision for the final closure of the 318,000 square foot 105-P Reactor was determined to be in situ decommissioning (ISD). ISD is an acceptable and cost effective alternative to off-site disposal for the reactor building, which will allow for consolidation of remedial action wastes generated from other cleanup activities within the P Area. ISD is considered protective by the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), public and stakeholders as waste materials are stabilized/immobilized, and radioactivity is allowed to naturally decay, thus preventing future exposure to the environment. Stakeholder buy-in was critical in the upfront planning in order to achieve this monumental final decision. Numerous public meetings and workshops were held in two different states (covering a 200 mile radius) with stakeholder and SRS Citizens Advisory Board participation. These meetings were conducted over an eight month period as the end state decision making progressed. Information provided to the public evolved from workshop to workshop as data became available and public input from the public meetings were gathered. ISD is being considered for the balance of the four SRS reactors and other hardened facilities such as the chemical processing canyons.

  19. An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation

    PubMed Central

    Brundin, L; Sellgren, C M; Lim, C K; Grit, J; Pålsson, E; Landén, M; Samuelsson, M; Lundgren, K; Brundin, P; Fuchs, D; Postolache, T T; Traskman-Bendz, L; Guillemin, G J; Erhardt, S

    2016-01-01

    Emerging evidence suggests that inflammation has a key role in depression and suicidal behavior. The kynurenine pathway is involved in neuroinflammation and regulates glutamate neurotransmission. In the cerebrospinal fluid (CSF) of suicidal patients, levels of inflammatory cytokines and the kynurenine metabolite quinolinic acid (QUIN), an N-methyl-d-aspartate receptor agonist, are increased. The enzyme amino-β-carboxymuconate-semialdehyde-decarboxylase (ACMSD) limits QUIN formation by competitive production of the neuroprotective metabolite picolinic acid (PIC). Therefore, decreased ACMSD activity can lead to excess QUIN. We tested the hypothesis that deficient ACMSD activity underlies suicidal behavior. We measured PIC and QUIN in CSF and plasma samples from 137 patients exhibiting suicidal behavior and 71 healthy controls. We used DSM-IV and the Montgomery-Åsberg Depression Rating Scale and Suicide Assessment Scale to assess behavioral changes. Finally, we genotyped ACMSD tag single-nucleotide polymorphisms (SNPs) in 77 of the patients and 150 population-based controls. Suicide attempters had reduced PIC and a decreased PIC/QUIN ratio in both CSF (P<0.001) and blood (P=0.001 and P<0.01, respectively). The reductions of PIC in CSF were sustained over 2 years after the suicide attempt based on repeated measures. The minor C allele of the ACMSD SNP rs2121337 was more prevalent in suicide attempters and associated with increased CSF QUIN. Taken together, our data suggest that increased QUIN levels may result from reduced activity of ACMSD in suicidal subjects. We conclude that measures of kynurenine metabolites can be explored as biomarkers of suicide risk, and that ACMSD is a potential therapeutic target in suicidal behavior. PMID:27483383

  20. Transcription of the mating-type-regulated lncRNA IRT1 is governed by TORC1 and PKA.

    PubMed

    Moretto, Fabien; van Werven, Folkert J

    2016-08-12

    Cell fate decisions are controlled by multiple cell-intrinsic and -extrinsic factors. In budding yeast, the decision to enter gametogenesis or sporulation is dictated by nutrient availability and mating type. Recently, we showed that in diploid cells harbouring opposite mating types (MATa and MATα), the protein kinase A (PKA) and target of rapamycin complex I (TORC1) signalling pathways integrate at the promoter of the master regulatory transcription factor IME1 to control sporulation via nutrient availability (Weidberg, et al. 2016). In cells with a single mating type (MATa or MATα), however, IME1 is repressed by transcription through the IME1 promoter of a long non-coding RNA called IRT1, which prevents this cell type from undergoing sporulation. Here, we investigated the role of nutrient signalling in mating-type control of IME1. We find that expression of IRT1, like IME1 itself, depends on nutrient availability and the activities of PKA and TORC1. IRT1 transcription is repressed when nutrients are ample and TORC1 and PKA are active. In contrast, inhibition of PKA and TORC1 is sufficient to recruit Rme1 to the IRT1 promoter and induce IRT1-mediated repression of IME1. Finally, we provide evidence that IRT1 and IME1 are co-repressed by the Tup1-Cyc8 complex when nutrients are ample. Thus, in cells with a single mating-type nutrient availability regulates mating-type repression of IME1 and sporulation. Our results indicate that there is a hierarchy between nutrient and mating-type signals in controlling the decision to enter sporulation.

  1. ESTABLISHING FINAL END STATE FOR A RETIRED NUCLEAR WEAPONS PRODUCTION REACTOR; COLLABORATION BETWEEN STAKEHOLDERS, REGULATORS, AND THE FEDERAL GOVERNMENT - 11052

    SciTech Connect

    Bergren, C.; Flora, M.; Belencan, H.

    2010-11-17

    The Savannah River Site (SRS) is a 310-square-mile United States Department of Energy nuclear facility located along the Savannah River (SRS) near Aiken, South Carolina. Nuclear weapons material production began in the early 1950s, utilizing five production reactors. In the early 1990s all SRS production reactor operations were terminated. The first reactor closure end state declaration was recently institutionalized in a Comprehensive Environmental Response and Compensation and Liability Act (CERCLA) Early Action Record of Decision. The decision for the final closure of the 318,000 square foot 105-P Reactor was determined to be in situ decommissioning (ISD). ISD is an acceptable and cost effective alternative to off-site disposal for the reactor building, which will allow for consolidation of remedial action wastes generated from other cleanup activities within the P Area. ISD is considered protective by the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), public and stakeholders as waste materials are stabilized/immobilized, and radioactivity is allowed to naturally decay, thus preventing future exposure to the environment. Stakeholder buy-in was critical in the upfront planning in order to achieve this monumental final decision. Numerous public meetings and workshops were held in two different states (covering a 200 mile radius) with stakeholder and SRS Citizens Advisory Board participation. These meetings were conducted over an eight month period as the end state decision making progressed. Information provided to the public evolved from workshop to workshop as data became available and public input from the public meetings were gathered. ISD is being considered for the balance of the four SRS reactors and other hardened facilities such as the chemical Separation Facilities (canyons).

  2. The master regulator for biofilm formation in Bacillus subtilis governs the expression of an operon encoding secreted proteins required for the assembly of complex multicellular communities.

    SciTech Connect

    Branda, Steven S.; Losick, Richard; Kolter, Roberto; Kearns, Daniel B.; Chu, Frances

    2005-08-01

    Wild strains of Bacillus subtilis are capable of forming architecturally complex communities of cells known as biofilms. Critical to biofilm formation is the eps operon, which is believed to be responsible for the biosynthesis of an exopolysaccharide that binds chains of cells together in bundles. We report that transcription of eps is under the negative regulation of SinR, a repressor that was found to bind to multiple sites in the regulatory region of the operon. Mutations in sinR bypassed the requirement in biofilm formation of two genes of unknown function, ylbF and ymcA, and sinI, which is known to encode an antagonist of SinR. We propose that these genes are members of a pathway that is responsible for counteracting SinR-mediated repression. We further propose that SinR is a master regulator that governs the transition between a planktonic state in which the bacteria swim as single cells in liquid or swarm in small groups over surfaces, and a sessile state in which the bacteria adhere to each other to form bundled chains and assemble into multicellular communities.

  3. Military Government

    DTIC Science & Technology

    1949-07-01

    CGSC MG MILITARY GOVERNMENT LIBHARY ARI\\’IY WAR COLLEGE CJ\\RLISLE BARRACKS, PAa This text is approved for resident and extension-course...and functions · of ’ military government . It conforms ·substantially to the subject matter , of Field Manual 27-5, Civil Affairs/ Military Government ...Teaching experience at the Command and General Staff College has ···--·demonstrated the need for a military government text which brings to- gether

  4. Representation and misrepresentation of scientific evidence in contemporary tobacco regulation: a review of tobacco industry submissions to the UK Government consultation on standardised packaging.

    PubMed

    Ulucanlar, Selda; Fooks, Gary J; Hatchard, Jenny L; Gilmore, Anna B

    2014-03-01

    Standardised packaging (SP) of tobacco products is an innovative tobacco control measure opposed by transnational tobacco companies (TTCs) whose responses to the UK government's public consultation on SP argued that evidence was inadequate to support implementing the measure. The government's initial decision, announced 11 months after the consultation closed, was to wait for 'more evidence', but four months later a second 'independent review' was launched. In view of the centrality of evidence to debates over SP and TTCs' history of denying harms and manufacturing uncertainty about scientific evidence, we analysed their submissions to examine how they used evidence to oppose SP. We purposively selected and analysed two TTC submissions using a verification-oriented cross-documentary method to ascertain how published studies were used and interpretive analysis with a constructivist grounded theory approach to examine the conceptual significance of TTC critiques. The companies' overall argument was that the SP evidence base was seriously flawed and did not warrant the introduction of SP. However, this argument was underpinned by three complementary techniques that misrepresented the evidence base. First, published studies were repeatedly misquoted, distorting the main messages. Second, 'mimicked scientific critique' was used to undermine evidence; this form of critique insisted on methodological perfection, rejected methodological pluralism, adopted a litigation (not scientific) model, and was not rigorous. Third, TTCs engaged in 'evidential landscaping', promoting a parallel evidence base to deflect attention from SP and excluding company-held evidence relevant to SP. The study's sample was limited to sub-sections of two out of four submissions, but leaked industry documents suggest at least one other company used a similar approach. The TTCs' claim that SP will not lead to public health benefits is largely without foundation. The tools of Better Regulation

  5. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  6. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  7. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  8. 48 CFR 46.406 - Foreign governments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Foreign governments. 46... MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.406 Foreign governments. Government contract quality assurance performed for foreign governments or international agencies shall...

  9. The case for OFSMOKE: how tobacco price regulation is needed to promote the health of markets, government revenue and the public

    PubMed Central

    Branston, J Robert; Sweanor, David

    2010-01-01

    Mainstream economic theory outlines four main causes of market failure and it is already well established that two of these (information failure and externalities) exist in a tobacco market. A third cause of market failure, market power, is also a serious problem in many tobacco markets. Market power—combined with unintended and often overlooked consequences of tobacco tax policies, notably that gradual increases in specific taxes may allow the industry to disguise significant price increases—has, at least in high income countries, given cigarette manufacturers considerable pricing power and profits. This paper examines ways this market failure could be addressed and proposes as a solution a system of price cap regulation wherein a cap is placed on the pre-tax cigarette manufacturers' price but not on the retail price that consumers face. Well established in the utilities industry, price cap regulation would set a maximum price that cigarette companies can charge for their product based on an assessment of the genuine costs each firm faces in its operations and an assumption about the efficiency savings it would be expected to make. Such a system would achieve three main benefits. First, it would address the problem of market failure and excess profits while simultaneously allowing current tobacco control policies, including tax and price increases, to expand—thus tax increases would remain a central tenet of tobacco control policies and retail prices could continue to increase. Second, it would increase government revenue by transferring the excess profits from the industry to the government purse. Third, it would bring numerous public health benefits. In addition to addressing market power, while simultaneously allowing tobacco control policies to expand, it could offer a means of preventing down-trading to cheaper products and controlling unwanted industry practices such as cigarette smuggling, price fixing and marketing to the young. The paper outlines in

  10. An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series.

    PubMed

    Brown, Amy Christine

    2017-09-01

    This is the first of five review articles investigating dietary supplements (DS; includes herbs) that now exceed over 50,000 in the Office of Dietary Supplement's "Dietary Supplement Label Database." Four review articles follow summarizing published medical case reports of DS related to liver toxicity, kidney toxicity, heart toxicity, and cancer. The most popular DS were vitamin or mineral supplements (43%) followed by specialty supplements (20%), botanicals (20%; herbs), and sports supplements (16%). The 2013 Annual Report of the American Association of Poison Control Centers revealed 1692 fatalities due to drugs, and zero deaths due to DS. Less than 1 percent of Americans experience adverse events related to DS, and the majority was classified as minor, with many of these related to caffeine, yohimbe, or other stimulant ingredients. The number one adulterant in DS is drugs, followed by New Dietary Ingredients (NDI) not submitted to the FDA - both are illegal and not DS, but rather "tainted products marketed as dietary supplements." The three main categories of DS prone to medical problems are those for sexual enhancement, weight loss, and sports performance/body building. DS are regulated in the U.S. by several federal agencies with overlapping jurisdiction - the Food and Drug Administration (FDA) and the Federal Trade Commission (FTC); enforced by the State Attorneys General Offices (AGO) and Department of Justice (DOJ); and monitored (not regulated) by the Centers for Disease Control and Prevention (CDC). The FDA can remove a DS from the market for phase IV post-marketing surveillance adverse event reports, adulteration (drugs, NDI, synthetic substances), contamination, misidentification, mislabeling or false claims, and not meeting good manufacturing practices (GMP). The FTC and state AGO can also enforce laws against deceptive marketing practices. Suggested improvements to current regulatory requirements are included along with online DS Toxic Tables in the

  11. The case for OFSMOKE: how tobacco price regulation is needed to promote the health of markets, government revenue and the public.

    PubMed

    Gilmore, Anna B; Branston, J Robert; Sweanor, David

    2010-10-01

    Mainstream economic theory outlines four main causes of market failure and it is already well established that two of these (information failure and externalities) exist in a tobacco market. A third cause of market failure, market power, is also a serious problem in many tobacco markets. Market power--combined with unintended and often overlooked consequences of tobacco tax policies, notably that gradual increases in specific taxes may allow the industry to disguise significant price increases--has, at least in high income countries, given cigarette manufacturers considerable pricing power and profits. This paper examines ways this market failure could be addressed and proposes as a solution a system of price cap regulation wherein a cap is placed on the pre-tax cigarette manufacturers' price but not on the retail price that consumers face. Well established in the utilities industry, price cap regulation would set a maximum price that cigarette companies can charge for their product based on an assessment of the genuine costs each firm faces in its operations and an assumption about the efficiency savings it would be expected to make. Such a system would achieve three main benefits. First, it would address the problem of market failure and excess profits while simultaneously allowing current tobacco control policies, including tax and price increases, to expand--thus tax increases would remain a central tenet of tobacco control policies and retail prices could continue to increase. Second, it would increase government revenue by transferring the excess profits from the industry to the government purse. Third, it would bring numerous public health benefits. In addition to addressing market power, while simultaneously allowing tobacco control policies to expand, it could offer a means of preventing down-trading to cheaper products and controlling unwanted industry practices such as cigarette smuggling, price fixing and marketing to the young. The paper outlines in

  12. To Government Regulations Be True.

    ERIC Educational Resources Information Center

    Gardner, Carrie

    2002-01-01

    Describes school-district compliance requirements for two recently enacted federal laws designed to protect children from obscene, pornographic, or harmful materials available on the Internet: Children's Internet Protection Act and Neighborhood Children's Internet Protection Act. District eligibility for federal funds, including the E-rate…

  13. Governance and Institutional Autonomy: Governing and Governance in Portuguese Higher Education

    ERIC Educational Resources Information Center

    Magalhaes, Antonio; Veiga, Amelia; Ribeiro, Filipa; Amaral, Alberto

    2013-01-01

    This paper aims at looking at governance instruments beyond managerial technicality. It intends to do so by analysing the impact of governance reforms on the universities autonomy assumed as a regulation instrument to politically steer systems and institutions. The regulation efforts undertaken at the European and national levels reflect a trend…

  14. Governance and Institutional Autonomy: Governing and Governance in Portuguese Higher Education

    ERIC Educational Resources Information Center

    Magalhaes, Antonio; Veiga, Amelia; Ribeiro, Filipa; Amaral, Alberto

    2013-01-01

    This paper aims at looking at governance instruments beyond managerial technicality. It intends to do so by analysing the impact of governance reforms on the universities autonomy assumed as a regulation instrument to politically steer systems and institutions. The regulation efforts undertaken at the European and national levels reflect a trend…

  15. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  16. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  17. 48 CFR 245.602 - Reutilization of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Government property. 245.602 Section 245.602 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 245.602 Reutilization of Government property....

  18. Reinventing Government.

    ERIC Educational Resources Information Center

    Osborne, David T.

    1993-01-01

    Throughout all levels of American government, a shift is taking place from the rigid, wasteful, centralized bureaucracies of the industrial era to the more flexible, entrepreneurial, decentralized government needed to succeed in today's world. This shift has been brought about by an unprecedented, ongoing fiscal crisis that has created a sudden…

  19. Remaking Governance.

    ERIC Educational Resources Information Center

    Carver, John

    2000-01-01

    The Policy Governance model's philosophical foundations lie in Rousseau's social contract, Greenleaf's servant-leadership, and modern management theory. Policy Governance stresses primacy of the owner-representative role; full-board authority; superintendents as chief executive officers; authoritative prescription of "ends," bounded…

  20. Representation and Misrepresentation of Scientific Evidence in Contemporary Tobacco Regulation: A Review of Tobacco Industry Submissions to the UK Government Consultation on Standardised Packaging

    PubMed Central

    Ulucanlar, Selda; Fooks, Gary J.; Hatchard, Jenny L.; Gilmore, Anna B.

    2014-01-01

    Background Standardised packaging (SP) of tobacco products is an innovative tobacco control measure opposed by transnational tobacco companies (TTCs) whose responses to the UK government's public consultation on SP argued that evidence was inadequate to support implementing the measure. The government's initial decision, announced 11 months after the consultation closed, was to wait for ‘more evidence’, but four months later a second ‘independent review’ was launched. In view of the centrality of evidence to debates over SP and TTCs' history of denying harms and manufacturing uncertainty about scientific evidence, we analysed their submissions to examine how they used evidence to oppose SP. Methods and Findings We purposively selected and analysed two TTC submissions using a verification-oriented cross-documentary method to ascertain how published studies were used and interpretive analysis with a constructivist grounded theory approach to examine the conceptual significance of TTC critiques. The companies' overall argument was that the SP evidence base was seriously flawed and did not warrant the introduction of SP. However, this argument was underpinned by three complementary techniques that misrepresented the evidence base. First, published studies were repeatedly misquoted, distorting the main messages. Second, ‘mimicked scientific critique’ was used to undermine evidence; this form of critique insisted on methodological perfection, rejected methodological pluralism, adopted a litigation (not scientific) model, and was not rigorous. Third, TTCs engaged in ‘evidential landscaping’, promoting a parallel evidence base to deflect attention from SP and excluding company-held evidence relevant to SP. The study's sample was limited to sub-sections of two out of four submissions, but leaked industry documents suggest at least one other company used a similar approach. Conclusions The TTCs' claim that SP will not lead to public health benefits is largely

  1. States turn up the heat. As self-regulation sputters, state legislatures are leading charge for more accountability in governance of not-for-profit hospitals.

    PubMed

    Mantone, Joseph

    2006-01-30

    Recent scandals have pushed some states to tackle transparency and governance issues at healthcare not-for-profits, which the federal government has been reluctant to touch. Rhode Island Lt. Gov. Charles Fogarty, left, supports a bill in his state that would establish a code of ethics for hospital boards. Fogarty sees leaders as getting too comfortable in their jobs and working without accountability.

  2. Biology and the Government

    ERIC Educational Resources Information Center

    Reid, Roger D.

    1969-01-01

    Emphasizes the social implications of biological knowledge and discusses two main government roles in biology: (1) a creative and supportive role, including support of education and research, (2) control, regulation and protection related to the applications of biological knowledge. Public control is considered necessary in areas such as food and…

  3. Biology and the Government

    ERIC Educational Resources Information Center

    Reid, Roger D.

    1969-01-01

    Emphasizes the social implications of biological knowledge and discusses two main government roles in biology: (1) a creative and supportive role, including support of education and research, (2) control, regulation and protection related to the applications of biological knowledge. Public control is considered necessary in areas such as food and…

  4. Government Agencies

    DTIC Science & Technology

    1988-05-01

    large, complex , and difficult to manage. U.S. Government procurement is the largest business enterprise in the world affecting the security...listed in this study.) With the single exception of rocket and spacecraft acquisitions, ship acquisitions are the highest cost and most complex ...acquisitions U.S. Government agencies undertake. Many factors influence the level of complexity for a given ship acquisition program. Between the Navy and

  5. Governing the Governance of Education: The State Strikes Back?

    ERIC Educational Resources Information Center

    Hudson, Christine

    2007-01-01

    In many countries, there have been changes in the way in which education is governed, with greater fragmentation of responsibility between the state, local government, schools, individuals and the market often accompanied by a move from detailed regulation to framework legislation. Previously, these developments have been seen as part of the move…

  6. 3 CFR - Managing Government Records

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... requirements in law, regulation, and this memorandum is a priority for senior agency management; (ii) ensure... (Archivist), a senior agency official to supervise the review required by subsection (b) of this section, in...) increasing open Government and appropriate public access to Government records; (v) supporting...

  7. Auditing Government Transportation Bills

    DTIC Science & Technology

    1988-12-01

    of the Comptroller of the United States, June 5, 1974, U.S. Government Printing Office, Washington, D.C. 1974. 13. Ballou , Ronald H., Business ...Transportation Policy I Office of the Assistant Secretary of Defense (Production and Logistics ) Washington, D.C. 20301-8000 8. Naval Supply Systems Command 1...of Federal Regulations CONUS Continential United States DLA Defense Logistics Agency DOD Department of Defense EDI Electronic Data Interchange EFT

  8. 48 CFR 945.602 - Reutilization of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government property. 945.602 Section 945.602 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY Reporting, Reutilization, and Disposal 945.602 Reutilization of Government property....

  9. 48 CFR 1845.7210 - Contractor utilization of Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contractor utilization of Government property. 1845.7210 Section 1845.7210 Federal Acquisition Regulations System NATIONAL AERONAUTICS....7210 Contractor utilization of Government property. ...

  10. 48 CFR 246.470 - Government contract quality assurance actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... quality assurance actions. 246.470 Section 246.470 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.470 Government contract quality assurance actions....

  11. Government Publications

    ERIC Educational Resources Information Center

    Whitlatch, Jo Bell

    1977-01-01

    This essay lists resources on drug information. Topics include classes of drugs, drugs which are abused, identification of drug abusers, drug education, national patterns of abuse and treatment, drug toxicity and poisoning, federal regulations, federal enforcement efforts and strategies, and the relationship of drugs and crime. (JAB)

  12. 16 CFR 460.21 - Government claims.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Government claims. 460.21 Section 460.21 Commercial Practices FEDERAL TRADE COMMISSION TRADE REGULATION RULES LABELING AND ADVERTISING OF HOME INSULATION § 460.21 Government claims. Do not say or imply that a government agency uses,...

  13. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  14. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  15. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  16. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  17. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  18. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  19. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  20. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  1. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  2. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  3. 7 CFR 3015.191 - Governments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Governments. 3015.191 Section 3015.191 Agriculture... AGRICULTURE UNIFORM FEDERAL ASSISTANCE REGULATIONS Cost Principles § 3015.191 Governments. (a) OMB Circular No... be used in determining the allowable costs of activities conducted by governments. (b)...

  4. 48 CFR 246.406 - Foreign governments.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Foreign governments. 246..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 246.406 Foreign governments. (1) Quality assurance among North Atlantic Treaty Organization (NATO) countries....

  5. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  6. 48 CFR 836.572 - Government supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government supervision... CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Contract Clauses 836.572 Government supervision. The contracting officer shall insert the clause at 852.236-78, Government supervision,...

  7. 42 CFR 494.180 - Condition: Governance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... governing body, or designated person(s) with full legal authority and responsibility for the governance and operation of the facility. The governing body adopts and enforces rules and regulations relative to its...

  8. 48 CFR 225.7303-3 - Government-to-government agreements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government-to-government agreements. 225.7303-3 Section 225.7303-3 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Acquisitions for Foreign...

  9. 48 CFR 227.674 - Supply contracts between the Government and a foreign government or concern.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Supply contracts between the Government and a foreign government or concern. 227.674 Section 227.674 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL...

  10. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government furnished... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert clause 1352.245-70, Government Furnished Property, when Government property is to be furnished to...

  11. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government furnished... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property...

  12. 48 CFR 1352.245-70 - Government furnished property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government furnished... Government furnished property. As prescribed in 48 CFR 1345.107-70, insert the following clause: Government Furnished Property (APR 2010) The Government will provide the following item(s) of Government property...

  13. Government Action in Universities and Colleges.

    ERIC Educational Resources Information Center

    Loftus, Elizabeth F.

    The Federal Government seeks to achieve a multitude of objectives that concern the academic and scientific community. Setting aside the issue of whether the government should be regulating everything from birth control to rat control, and whether the regulations should be improved or clarified, a major question is: why piggyback the government…

  14. Exploring the Context and Implementation of Public Health Regulations Governing Sex Work: A Qualitative Study with Migrant Sex Workers in Guatemala.

    PubMed

    Rocha-Jiménez, Teresita; Brouwer, Kimberly C; Silverman, Jay G; Morales-Miranda, Sonia; Goldenberg, Shira M

    2016-03-25

    Public health regulations practices surrounding sex work and their enforcement can have unintended consequences for HIV and sexually transmitted infection (STI) prevention and care among sex workers. This analysis was based on qualitative in-depth (n = 33) and focus groups interviews (n = 20) conducted with migrant female sex workers in Tecún Umán and Quetzaltenango, Guatemala, and explored the implementation of sex work regulations and related consequences for HIV prevention and care among migrant sex workers. Sex work regulations were found to have health-related benefits (e.g., access to HIV/STI testing) as well as negative impacts, such as abuse by police and harassment, detention/deportation of migrant sex workers. Whereas public health regulations may improve access to HIV/STI testing, their implementation may inadvertently jeopardize sex workers' health through unintended negative consequences. Non-coercive, evidence-based public health and sex work policies and programs are needed to expand access to HIV/STI prevention and care among migrant sex workers, while protecting their dignity and human rights.

  15. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Tribe or Tribal organization include in a Tribal IV-D plan? 309.90 Section 309.90 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL CHILD...

  16. 45 CFR 309.90 - What governing Tribal law or regulations must a Tribe or Tribal organization include in a Tribal...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Tribe or Tribal organization include in a Tribal IV-D plan? 309.90 Section 309.90 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT (CHILD SUPPORT ENFORCEMENT PROGRAM), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES TRIBAL CHILD...

  17. The Aspergillus fumigatus StuA Protein Governs the Up-Regulation of a Discrete Transcriptional Program during the Acquisition of Developmental CompetenceD⃞

    PubMed Central

    Sheppard, Donald C.; Doedt, Thomas; Chiang, Lisa Y.; Kim, H. Stanley; Chen, Dan; Nierman, William C.; Filler, Scott G.

    2005-01-01

    Members of the Asm1p, Phd1p, Sok2p, Efg1p, and StuAp (APSES) family of fungal proteins regulate morphogenesis and virulence in ascomycetes. We cloned the Aspergillus fumigatus APSES gene encoding StuAp and demonstrated that stuA transcription is markedly up-regulated after the acquisition of developmental competence. A. fumigatus ΔstuA mutants were impaired in their ability to undergo asexual reproduction. Conidiophore morphology was markedly abnormal, and only small numbers of dysmorphic conidia were produced, which exhibited precocious germination. Whole genome transcriptional analysis during the onset of developmental competence was performed and identified a subset of developmentally regulated genes that were stuA dependent, including a cluster of putative secondary metabolite biosynthesis genes, genes encoding proteins implicated in the regulation of morphogenesis, and genes encoding allergens and other antigenic proteins. Additionally, hyphae of the ΔstuA mutant displayed reduced expression of the catalase gene CAT1 and were hypersusceptible to hydrogen peroxide. PMID:16207816

  18. MicroRNA-302/367 Cluster Governs hESC Self-Renewal by Dually Regulating Cell Cycle and Apoptosis Pathways

    PubMed Central

    Zhang, Zhonghui; Hong, Yuanfan; Xiang, Di; Zhu, Pei; Wu, Elise; Li, Wen; Mosenson, Jeffrey; Wu, Wen-Shu

    2015-01-01

    Summary miR-302/367 is the most abundant miRNA cluster in human embryonic stem cells (hESCs) and can promote somatic cell reprogramming. However, its role in hESCs remains poorly understood. Here, we studied functional roles of the endogenous miR-302/367 cluster in hESCs by employing specific TALE-based transcriptional repressors. We revealed that miR-302/367 cluster dually regulates hESC cell cycle and apoptosis in dose-dependent manner. Gene profiling and functional studies identified key targets of the miR-302/367 cluster in regulating hESC self-renewal and apoptosis. We demonstrate that in addition to its role in cell cycle regulation, miR-302/367 cluster conquers apoptosis by downregulating BNIP3L/Nix (a BH3-only proapoptotic factor) and upregulating BCL-xL expression. Furthermore, we show that butyrate, a natural compound, upregulates miR-302/367 cluster expression and alleviates hESCs from apoptosis induced by knockdown of miR-302/367 cluster. In summary, our findings provide new insights in molecular mechanisms of how miR-302/367 cluster regulates hESCs. PMID:25801506

  19. MicroRNA-302/367 cluster governs hESC self-renewal by dually regulating cell cycle and apoptosis pathways.

    PubMed

    Zhang, Zhonghui; Hong, Yuanfan; Xiang, Di; Zhu, Pei; Wu, Elise; Li, Wen; Mosenson, Jeffrey; Wu, Wen-Shu

    2015-04-14

    miR-302/367 is the most abundant miRNA cluster in human embryonic stem cells (hESCs) and can promote somatic cell reprogramming. However, its role in hESCs remains poorly understood. Here, we studied functional roles of the endogenous miR-302/367 cluster in hESCs by employing specific TALE-based transcriptional repressors. We revealed that miR-302/367 cluster dually regulates hESC cell cycle and apoptosis in dose-dependent manner. Gene profiling and functional studies identified key targets of the miR-302/367 cluster in regulating hESC self-renewal and apoptosis. We demonstrate that in addition to its role in cell cycle regulation, miR-302/367 cluster conquers apoptosis by downregulating BNIP3L/Nix (a BH3-only proapoptotic factor) and upregulating BCL-xL expression. Furthermore, we show that butyrate, a natural compound, upregulates miR-302/367 cluster expression and alleviates hESCs from apoptosis induced by knockdown of miR-302/367 cluster. In summary, our findings provide new insights in molecular mechanisms of how miR-302/367 cluster regulates hESCs. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  20. An Exploratory Study of Professional Practices among School Psychologists in Response to the Revised Chapter 14 Regulations Governing Student Evaluation Timeframes

    ERIC Educational Resources Information Center

    Priel, David M.

    2009-01-01

    In an effort to align state special education law with federal legislation under the Individuals with Disabilities Education Act of 2004, Pennsylvania has adopted Chapter 14 special education regulations. Chapter 14 is designed to ensure that every student with a disability is afforded a free and appropriate public education designed to provide…

  1. Role of miRNA dynamics and cytokine profile in governing CD44v6/Nanog/PTEN axis in oral cancer: modulating the master regulators.

    PubMed

    Patel, Shanaya; Rawal, Rakesh

    2016-11-01

    Late diagnosis, low therapeutic response, and metastasis are accountable for poor 5-year survival rate of OSCC. These failures are attributed to the existence of "cancer stem cell (CSC)" subpopulation. Hence, it is necessary to identify and understand the mechanism of CSCs in tumor development, metastasis, and chemotherapeutic response. Propelling evidences suggest that microRNA (miRNA)-mediated regulation and cytokines of tumor microenvironment have the ability to modulate CSC signalling pathway; however, their exact mechanism needs to be elucidated. Thus, in this study, we characterized CSC markers and highlighted the miRNA dynamics and cytokine profile regulating these CSCs in a pathway-dependent manner. Our results demonstrated CD44+ subpopulation as tumor-initiating cells with self-renewal capability, tumorigenic growth potential and intrinsic chemoresistance. These tumors exhibited increased expression of CSC markers (CD44v3, CD44v6, Nanog, and Bmi1) and significantly reduced expression of PTEN and ATM in OSCC patients. Pathway analysis of these CSC markers demonstrated a prospective pathway regulated by miRNA and cytokine network. On analyzing these modulators, we observed decreased expression of miRNA542-3p, miRNA34a and miRNA9, and significant upregulation of miRNA21, thus forming an unexplored axis. Cytokine profiling revealed significantly increased levels of IL-6 and IL-8 compared to normals and demonstrated their strong association with CD44v6. Collectively, this study indicates that miR5423p and miR34a targets the CD44v6-Nanog-PTEN axis, thus playing a vital role in regulating the CSC properties. Furthermore, we speculate an impinging role of cytokines IL-6 and IL-8 in regulating this CSC-mediated pathway which can have prognostic and therapeutic implications.

  2. 48 CFR 46.408 - Single-agency assignments of Government contract quality assurance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of Government contract quality assurance. 46.408 Section 46.408 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 46.408 Single-agency assignments of Government contract quality assurance. (a)...

  3. Earthquake resistant construction of gas and liquid fuel pipeline systems serving, or regulated by, the Federal government. Earthquake hazard reduction series No. 67

    SciTech Connect

    Yokel, F.Y.; Mathey, R.G.

    1992-07-01

    The vulnerability of gas and liquid fuel pipeline systems to damage in past earthquakes, as well as available standards and technologies that can protect these facilities against earthquake damage are reviewed. An overview is presented of measures taken by various Federal Agencies to protect pipeline systems under their jurisdiction against earthquake hazards. It is concluded that the overall performance of pipeline systems in past earthquakes was relatively good, however, older pipelines and above-ground storage tanks were damaged in many earthquakes. Standards and regulations for liquid fuel pipelines contain only general references to seismic loads. Standards and regulations for above-ground fuel storage tanks and for liquefied natural gas facilities contain explicit seismic design provisions. It is recommended that a guideline for earthquake resistant design of gas and liquid fuel pipeline systems be prepared for Federal Agencies to ensure a uniform approach to the protection of these systems.

  4. Conjugal transfer of the Sinorhizobium meliloti 1021 symbiotic plasmid is governed through the concerted action of one- and two-component signal transduction regulators.

    PubMed

    Nogales, Joaquina; Blanca-Ordóñez, Helena; Olivares, José; Sanjuán, Juan

    2013-03-01

    Conjugal transfer of Sinorhizobium meliloti and Rhizobium etli symbiotic plasmids are repressed by the transcriptional regulator RctA. Here we report on new key players in the signal transduction cascade towards S. meliloti pSym conjugation. We have identified S. meliloti pSymA gene SMa0974 as an orthologue of the R. etli rctB gene which is required to antagonize repression by RctA. In S. meliloti two additional genes, rctR and rctC participate in control of rctB expression. rctR (SMa0955) encodes a protein of the GntR family of transcriptional regulators involved in repression of rctB. A rctR mutant promotes pSymA conjugal transfer and displays increased transcription of tra, virB and rctB genes even in presence of wild-type rctA gene. Among genes repressed by RctR, rctC (SMa0961) encodes a response regulator required to activate rctB transcription and therefore for derepression of plasmid conjugative functions. We conclude that in both R. etli and S. meliloti pSym conjugal transfer is derepressed via rctB, however the regulatory cascades to achieve activation of rctB are probably different. Upstream of rctB, the S. meliloti pSym conjugal transfer is regulated through the concerted action of genes representing one- (rctR) and two-component (rctC) signal transduction systems in response to yet unidentified signals. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  5. A Study of Approval Plans and the Government’s Ability to Contract for Them under the Federal Acquisition Regulation (FAR)

    DTIC Science & Technology

    1989-12-01

    along with procedural methods for implementing approval plans under current Department of Defense regulations. NTFIS GRASA DTIC TAB0 Just Ifced1 By...with loshiba MAP 1988 Corporation or Kongsberg Vapenfabrikk.- OfferorS Representation 52.225-17027 Restriction on Contracting with Toshiba MAR 1988... Corporation or Kongsberg Vapenfabrikk 52.227-7031( P Data Requirements APR 1912 52-232-7007( P Progress Payments - Alternate I OCT 1916 52.233-100( P

  6. Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways.

    PubMed

    Park, Junghyung; Min, Ju-Sik; Kim, Bokyung; Chae, Un-Bin; Yun, Jong Won; Choi, Myung-Sook; Kong, Il-Keun; Chang, Kyu-Tae; Lee, Dong-Seok

    2015-01-01

    Activation of microglia cells in the brain contributes to neurodegenerative processes promoted by many neurotoxic factors such as pro-inflammatory cytokines and nitric oxide (NO). Reactive oxygen species (ROS) actively affect microglia-associated neurodegenerative diseases through their role as pro-inflammatory molecules and modulators of pro-inflammatory processes. Although the ROS which involved in microglia activation are thought to be generated primarily by NADPH oxidase (NOX) and involved in the immune response, mitochondrial ROS have also been proposed as important regulators of the inflammatory response in the innate immune system. However, the role of mitochondrial ROS in microglial activation has yet to be fully elucidated. In this study, we demonstrate that inhibition of mitochondrial ROS by treatment with Mito-TEMPO effectively suppressed the level of mitochondrial and intracellular ROS. Mito-TEMPO treatment also significantly prevented LPS-induced increase in the TNF-α, IL-1β, IL-6, iNOS and Cox-2 in BV-2 and primary microglia cells. Furthermore, LPS-induced suppression of mitochondrial ROS generation not only affected LPS-stimulated activation of MAPKs, including ERK, JNK, and p38, but also regulated IκB activation and NF-κB nuclear localization. These results indicate that mitochondria constitute a major source of ROS generation in LPS-mediated activated microglia cells. Additionally, suppression of LPS-induced mitochondrial ROS plays a role in modulating the production of pro-inflammatory mediators by preventing MAPK and NF-κB activation in microglia cells. Our findings suggest that a potential strategy in the development of therapy for inflammation-associated degenerative neurological diseases involves targeting the regulation of mitochondrial ROS in microglial cells.

  7. Regulation of the dnaK operon of Streptomyces coelicolor A3(2) is governed by HspR, an autoregulatory repressor protein.

    PubMed Central

    Bucca, G; Hindle, Z; Smith, C P

    1997-01-01

    The dnaK operon of Streptomyces coelicolor contains four genes (5'-dnaK-grpE-dnaJ-hspR). The fourth gene encodes a novel heat shock protein, HspR, which appears so far to be unique to the high-G+C actinomycete group of bacteria. HspR binds with high specificity to three inverted repeat sequences in the promoter region of the S. coelicolor dnaK operon, strongly suggesting a direct role for HspR in heat shock gene regulation. Here we present genetic and biochemical evidence that HspR is the repressor of the dnaK operon. Disruption of hspR leads to high-level constitutive transcription of the dnaK operon. Parallel transcriptional analyses of groESL1 and groEL2 expression demonstrated that heat shock regulation of the groE genes was essentially unaffected in an hspR null mutant, although the basal (uninduced) level of groEL2 transcription was slightly elevated compared with the wild type. The results of HspR titration experiments, where the dnaK operon promoter region was cloned at ca. 50 copies per chromosome, were consistent with the prediction that HspR functions as a negative autoregulator. His-tagged HspR, overproduced and purified from Escherichia coli, was shown to repress transcription from the dnaK operon promoter in vitro, providing additional evidence for the proposal that HspR directly regulates transcription of the dnaK operon. These studies indicate that there are at least two transcriptional mechanisms for controlling heat shock genes in S. coelicolor--one controlling the dnaK operon and another controlling the groE genes. PMID:9324243

  8. Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity.

    PubMed

    Long, Mark D; van den Berg, Patrick R; Russell, James L; Singh, Prashant K; Battaglia, Sebastiano; Campbell, Moray J

    2015-09-03

    To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinations (24/44) were associated with significantly elevated level expression of protein coding genes and only very few combinations related to gene repression. DAVID's biological process annotation revealed that elevated gene expression was uniquely associated with acetylation and ETS binding. A matrix of gene and drug interactions built on NCI-60 data identified that Imatinib significantly targeted the NCOR1 governed transcriptome. Stable knockdown of NCOR1 in K562 cells slowed growth and significantly repressed genes associated with NCOR1 cistrome, again, with the GO terms acetylation and ETS binding, and significantly dampened sensitivity to Imatinib-induced erythroid differentiation. Mining public microarray data revealed that NCOR1-targeted genes were significantly enriched in Imatinib response gene signatures in cell lines and chronic myelogenous leukemia (CML) patients. These approaches integrated cistrome, transcriptome and drug sensitivity relationships to reveal that NCOR1 function is surprisingly most associated with elevated gene expression, and that these targets, both in CML cell lines and patients, associate with sensitivity to Imatinib.

  9. Integrative genomic analysis in K562 chronic myelogenous leukemia cells reveals that proximal NCOR1 binding positively regulates genes that govern erythroid differentiation and Imatinib sensitivity

    PubMed Central

    Long, Mark D.; van den Berg, Patrick R.; Russell, James L.; Singh, Prashant K.; Battaglia, Sebastiano; Campbell, Moray J.

    2015-01-01

    To define the functions of NCOR1 we developed an integrative analysis that combined ENCODE and NCI-60 data, followed by in vitro validation. NCOR1 and H3K9me3 ChIP-Seq, FAIRE-seq and DNA CpG methylation interactions were related to gene expression using bootstrapping approaches. Most NCOR1 combinations (24/44) were associated with significantly elevated level expression of protein coding genes and only very few combinations related to gene repression. DAVID's biological process annotation revealed that elevated gene expression was uniquely associated with acetylation and ETS binding. A matrix of gene and drug interactions built on NCI-60 data identified that Imatinib significantly targeted the NCOR1 governed transcriptome. Stable knockdown of NCOR1 in K562 cells slowed growth and significantly repressed genes associated with NCOR1 cistrome, again, with the GO terms acetylation and ETS binding, and significantly dampened sensitivity to Imatinib-induced erythroid differentiation. Mining public microarray data revealed that NCOR1-targeted genes were significantly enriched in Imatinib response gene signatures in cell lines and chronic myelogenous leukemia (CML) patients. These approaches integrated cistrome, transcriptome and drug sensitivity relationships to reveal that NCOR1 function is surprisingly most associated with elevated gene expression, and that these targets, both in CML cell lines and patients, associate with sensitivity to Imatinib. PMID:26117541

  10. Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A.

    PubMed

    Fujita, Masaya; Losick, Richard

    2005-09-15

    The transcription factor Spo0A is a master regulator for entry into sporulation in the bacterium Bacillus subtilis, but it has been uncertain whether activation of Spo0A is sufficient to trigger development. Spo0A, a member of the response regulator family of gene-control proteins, is activated by phosphorylation via a multicomponent phosphorelay in response to conditions of nutrient limitation. We now report that sporulation can be triggered with high efficiency in cells in the exponential phase of growth in rich medium by artificial induction of the synthesis of any one of three histidine kinases that feed phosphoryl groups into the relay. We further show that the levels of Spo0A protein and activity increase gradually over the first 2 h of sporulation both under conditions of nutrient limitation and in response to induction of kinase synthesis. Evidence indicates that this gradual increase in Spo0A protein and activity plays a critical role in triggering sporulation and requires the action of the phosphorelay.

  11. Innate signals overcome acquired TCR signaling pathway regulation and govern the fate of human CD161(hi) CD8α⁺ semi-invariant T cells.

    PubMed

    Turtle, Cameron J; Delrow, Jeff; Joslyn, Rochelle C; Swanson, Hillary M; Basom, Ryan; Tabellini, Laura; Delaney, Colleen; Heimfeld, Shelly; Hansen, John A; Riddell, Stanley R

    2011-09-08

    Type 17 programmed CD161(hi)CD8α(+) T cells contribute to mucosal immunity to bacteria and yeast. In early life, microbial colonization induces proliferation of CD161(hi) cells that is dependent on their expression of a semi-invariant Vα7.2(+) TCR. Although prevalent in adults, CD161(hi)CD8α(+) cells exhibit weak proliferative and cytokine responses to TCR ligation. The mechanisms responsible for the dichotomous response of neonatal and adult CD161(hi) cells, and the signals that enable their effector function, have not been established. We describe acquired regulation of TCR signaling in adult memory CD161(hi)CD8α(+) T cells that is absent in cord CD161(hi) cells and adult CD161(lo) cells. Regulated TCR signaling in CD161(hi) cells was due to profound alterations in TCR signaling pathway gene expression and could be overcome by costimulation through CD28 or innate cytokine receptors, which dictated the fate of their progeny. Costimulation with IL-1β during TCR ligation markedly increased proinflammatory IL-17 production, while IL-12-induced Tc1-like function and restored the response to TCR ligation without costimulation. CD161(hi) cells from umbilical cord blood and granulocyte colony stimulating factor-mobilized leukaphereses differed in frequency and function, suggesting future evaluation of the contribution of CD161(hi) cells in hematopoietic stem cell grafts to transplant outcomes is warranted.

  12. A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes

    PubMed Central

    Shah, Zahid H.; Ahmed, Shafiq U.; Ford, Jack R.; Allison, Simon J.; Knight, John R. P.

    2012-01-01

    SIRT1 is an NAD-dependent deacetylase and epigenetic regulator essential for normal mammalian development and homeostasis. Here we describe a human SIRT1 splice variant, designated SIRT1-Δ2/9, in which the deacetylase coding sequence is lost due to splicing between exons 2 and 9. This work aimed to determine if SIRT1-Δ2/9 is a novel functional product of the SIRT1 gene. Endogenous SIRT1-Δ2/9 protein was identified in human cell lysate by immunoblotting and splice variant-specific RNA interference (RNAi). SIRT1-Δ2/9 mRNA is bound by CUGBP2, which downregulates its translation. Using pulldown assays, we demonstrate that SIRT1-Δ2/9 binds p53 protein. SIRT1-Δ2/9 maintains basal p53 protein levels and supports p53 function in response to DNA damage, as evidenced by RNAi-mediated depletion of SIRT1-Δ2/9 prior to damage. In turn, basal p53 downregulates SIRT1-Δ2/9 RNA levels, while stress-activated p53 eliminates SIRT1-Δ2/9. Loss of wild-type (wt) p53 has been correlated with overexpression of SIRT1-Δ2/9 in a range of human cancers. Exogenous SIRT1-Δ2/9 protein associates with specific promoters in chromatin and can regulate cancer-related gene expression, as evidenced by chromatin immunoprecipitation analysis and RNAi/genomic array data. SIRT1 is of major therapeutic importance, and potential therapeutic drugs are screened against SIRT1 deacetylase activity. Our discovery of SIRT1-Δ2/9 identifies a new, deacetylase-independent therapeutic target for SIRT1-related diseases, including cancer. PMID:22124156

  13. Characterization of the cis elements in the proximal promoter regions of the anthocyanin pathway genes reveals a common regulatory logic that governs pathway regulation

    PubMed Central

    Zhu, Zhixin; Wang, Hailong; Wang, Yiting; Guan, Shan; Wang, Fang; Tang, Jingyu; Zhang, Ruijuan; Xie, Lulu; Lu, Yingqing

    2015-01-01

    Cellular activities such as compound synthesis often require the transcriptional activation of an entire pathway; however, the molecular mechanisms underlying pathway activation have rarely been explained. Here, the cis regulatory architecture of the anthocyanin pathway genes targeted by the transcription factor (TF) complex including MYB, bHLH, and WDR was systematically analysed in one species and the findings extended to others. In Ipomoea purpurea, the IpMYB1-IpbHLH2-IpWDR1 (IpMBW) complex was found to be orthologous to the PAP1-GL3-TTG1 (AtPGT) complex of Arabidopsis thaliana, and interacted with a 7-bp MYB-recognizing element (MRE) and a 6-bp bHLH-recognizing element (BRE) at the proximal promoter region of the pathway genes. There was little transcription of the gene in the absence of the MRE or BRE. The cis elements identified experimentally converged on two syntaxes, ANCNNCC for MREs and CACN(A/C/T)(G/T) for BREs, and our bioinformatic analysis showed that these were present within anthocyanin gene promoters in at least 35 species, including both gymnosperms and angiosperms. For the anthocyanin pathway, IpMBW and AtPGT recognized the interspecific promoters of both early and later genes. In A. thaliana, the seed-specific TF complex (TT2, TT8, and TTG1) may regulate all the anthocyanin pathway genes, in addition to the proanthocyanidin-specific BAN. When multiple TF complexes in the anthocyanin pathway were compared, the cis architecture played a role larger than the TF complex in determining the variation in promoter activity. Collectively, a cis logic common to the pathway gene promoters was found, and this logic is essential for the trans factors to regulate the pathway. PMID:25911741

  14. Do Kids Need Government Censors?

    ERIC Educational Resources Information Center

    Rabkin, Rhoda

    2002-01-01

    Fashioning public policies restricting children's access to entertainment glamorizing violence, sex, drugs, and vulgarity is a complex task. The recently introduced Media Marketing Accountability Act would empower the federal government to regulate advertising of entertainment products to youth. Suggests that this power is undesirable compared to…

  15. Do Kids Need Government Censors?

    ERIC Educational Resources Information Center

    Rabkin, Rhoda

    2002-01-01

    Fashioning public policies restricting children's access to entertainment glamorizing violence, sex, drugs, and vulgarity is a complex task. The recently introduced Media Marketing Accountability Act would empower the federal government to regulate advertising of entertainment products to youth. Suggests that this power is undesirable compared to…

  16. Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.

    PubMed

    Kowalczyk, Katarzyna M; Petersen, Janni

    2016-05-01

    Target of Rapamycin (TOR) signalling allows eukaryotic cells to adjust cell growth in response to changes in their nutritional and environmental context. The two distinct TOR complexes (TORC1/2) localise to the cell's internal membrane compartments; the endoplasmic reticulum (ER), Golgi apparatus and lysosomes/vacuoles. Here, we show that Ppk32, a SCYL family pseudo-kinase, is a novel regulator of TOR signalling. The absence of ppk32 expression confers resistance to TOR inhibition. Ppk32 inhibition of TORC1 is critical for cell survival following Brefeldin A (BFA) induced stress. Treatment of wild type cells with either the TORC1 specific inhibitor rapamycin or the general TOR inhibitor Torin1 confirmed that a reduction in TORC1 activity promoted recovery from BFA induced stress. Phosphorylation of Ppk32 on two residues that are conserved within the SCYL pseudo-kinase family are required for this TOR inhibition. Phosphorylation on these sites controls Ppk32 protein levels and sensitivity to BFA. BFA induced ER stress does not account for the response to BFA that we report here, however BFA is also known to induce Golgi stress and impair traffic to lysosomes. In summary, Ppk32 reduce TOR signalling in response to BFA induced stress to support cell survival.

  17. Genetic evidence that high noninduced maltase and maltose permease activities, governed by MALx3-encoded transcriptional regulators, determine efficiency of gas production by baker's yeast in unsugared dough.

    PubMed

    Higgins, V J; Braidwood, M; Bell, P; Bissinger, P; Dawes, I W; Attfield, P V

    1999-02-01

    Strain selection and improvement in the baker's yeast industry have aimed to increase the speed of maltose fermentation in order to increase the leavening activity of industrial baking yeast. We identified two groups of baker's strains of Saccharomyces cerevisiae that can be distinguished by the mode of regulation of maltose utilization. One group (nonlagging strains), characterized by rapid maltose fermentation, had at least 12-fold more maltase and 130-fold-higher maltose permease activities than maltose-lagging strains in the absence of inducing sugar (maltose) and repressing sugar (glucose). Increasing the noninduced maltase activity of a lagging strain 13-fold led to an increase in CO2 production in unsugared dough. This increase in CO2 production also was seen when the maltose permease activity was increased 55-fold. Only when maltase and maltose permease activities were increased in concert was CO2 production by a lagging strain similar to that of a nonlagging strain. The noninduced activities of maltase and maltose permease constitute the largest determinant of whether a strain displays a nonlagging or a lagging phenotype and are dependent upon the MALx3 allele. Previous strategies for strain improvement have targeted glucose derepression of maltase and maltose permease expression. Our results suggest that increasing noninduced maltase and maltose permease levels is an important target for improved maltose metabolism in unsugared dough.

  18. 48 CFR 53.245 - Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Government property. 53.245 Section 53.245 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED... property and in accounting for this property: (a) SF 120 (GSA), Report of Excess Personal Property, and...

  19. 48 CFR 1845.502-1 - Receipts for Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Receipts for Government property. 1845.502-1 Section 1845.502-1 Federal Acquisition Regulations System NATIONAL AERONAUTICS AND... Possession of Contractors 1845.502-1 Receipts for Government property. Receipts for Government property shall...

  20. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  1. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  2. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  3. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  4. 48 CFR 852.236-78 - Government supervision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Government supervision. 852.236-78 Section 852.236-78 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS... Government supervision. As prescribed in 836.572, insert the following clause: Government Supervision...

  5. 48 CFR 245.103-71 - Transferring Government property accountability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Transferring Government... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.103-71 Transferring Government property accountability. Follow the procedures at PGI 245.103-71...

  6. 48 CFR 245.103-71 - Transferring Government property accountability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Transferring Government... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 245.103-71 Transferring Government property accountability. Follow the procedures at PGI 245.103-71...

  7. 48 CFR 1345.107-70 - Government furnished property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Government furnished property. 1345.107-70 Section 1345.107-70 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1345.107-70 Government furnished property. Insert...

  8. 48 CFR 945.170 - Providing Government property to contractors.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Providing Government property to contractors. 945.170 Section 945.170 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 945.170 Providing Government property...

  9. 48 CFR 1545.107 - Government property clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Government property clauses. 1545.107 Section 1545.107 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1545.107 Government property clauses. (a) The...

  10. 48 CFR 2945.105 - Records of Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Records of Government property. 2945.105 Section 2945.105 Federal Acquisition Regulations System DEPARTMENT OF LABOR CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 2945.105 Records of Government property. Contracting officers must maintain a file on any...

  11. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay of...

  12. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay of...

  13. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  14. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  15. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  16. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  17. 31 CFR 540.304 - Government of the Russian Federation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Government of the Russian Federation...) AGREEMENT ASSETS CONTROL REGULATIONS General Definitions § 540.304 Government of the Russian Federation. (a) The term Government of the Russian Federation means the Government of the Russian Federation,...

  18. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  19. 48 CFR 52.251-1 - Government Supply Sources.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Government Supply Sources....251-1 Government Supply Sources. As prescribed in 51.107, insert the following clause: Government... Government supply sources in the performance of this contract. Title to all property acquired by...

  20. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  1. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  2. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  3. 48 CFR 252.227-7022 - Government rights (unlimited).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government rights... of Provisions And Clauses 252.227-7022 Government rights (unlimited). As prescribed at 227.7107-1(a), use the following clause: Government Rights (Unlimited) (MAR 1979) The Government shall have...

  4. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  5. 48 CFR 2945.105 - Records of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2945.105 Records of Government property. Contracting officers must maintain a file on any Government-furnished property (GFP) in the possession of contractors. As a...

  6. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  7. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUNE 1, 2009) (a) Inspection by Government personnel. (1) Supplies to...

  8. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  9. 48 CFR 2945.105 - Records of Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 7 2014-10-01 2014-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2945.105 Records of Government property. Contracting officers must maintain a file on any Government-furnished property (GFP) in the possession of contractors. As a...

  10. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUNE 1, 2009) (a) Inspection by Government personnel. (1) Supplies to...

  11. 48 CFR 2845.105 - Records of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Records of Government... MANAGEMENT GOVERNMENT PROPERTY General 2845.105 Records of Government property. If departmental elements maintain the Government's official property management records, the contract records may be kept as...

  12. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUN 2009) (a) Inspection by Government personnel. (1) Supplies to...

  13. 48 CFR 1552.237-76 - Government-Contractor Relations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government-Contractor... 1552.237-76 Government-Contractor Relations. As prescribed in 1537.110(g), insert the following clause: Government-Contractor Relations (JUN 1999) (a) The Government and the Contractor understand and agree...

  14. 48 CFR 908.7101-7 - Government license tags.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Government license tags... Government license tags. (a) Government license tags shall be procured and assignments recorded by DOE... the District of Columbia, official Government tags shall be obtained from the Department...

  15. 48 CFR 552.227-70 - Government Rights (Unlimited).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Government Rights....227-70 Government Rights (Unlimited). As prescribed in 527.409, insert the following clause: Government Rights (Unlimited) (MAY 1989) The Government shall have unlimited rights in all drawings,...

  16. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  17. 48 CFR 2452.227-70 - Government information.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Government information... 2452.227-70 Government information. As prescribed in 2427.470, use the following clause: Government Information (DEC 2012) (a) Definitions. As used in this clause, “Government information” includes—...

  18. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma (also known...

  19. 48 CFR 52.251-1 - Government Supply Sources.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Government Supply Sources....251-1 Government Supply Sources. As prescribed in 51.107, insert the following clause: Government... Government supply sources in the performance of this contract. Title to all property acquired by...

  20. 48 CFR 1552.245-70 - Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government property. 1552... Government property. As prescribed in 1545.107(a), insert a clause substantially the same as follows: Government Property Government Property (a) The contractor shall not fabricate or acquire, on behalf of...

  1. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  2. 48 CFR 47.207-8 - Government responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Government....207-8 Government responsibilities. (a) The contracting officer shall state clearly the Government's... Government's responsibility to notify the contractor in advance when hazardous materials are included in...

  3. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  4. 48 CFR 1952.227-76 - Government rights (unlimited).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government rights... 1952.227-76 Government rights (unlimited). As prescribed in 1927.405(g), insert the following clause: Government Rights (Unlimited) (FEB 1985) The Government shall have unlimited rights, in all drawings,...

  5. 48 CFR 552.246-71 - Source Inspection by Government.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Government. 552.246-71 Section 552.246-71 Federal Acquisition Regulations System GENERAL SERVICES....246-71 Source Inspection by Government. As prescribed in 546.302-71, insert the following clause: Source Inspection by Government (JUNE 1, 2009) (a) Inspection by Government personnel. (1) Supplies to...

  6. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  7. 48 CFR 1545.107 - Government property clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Government property... CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 1545.107 Government property clauses. (a) The Contracting... use Government-furnished or Contractor-acquired property in the cleanup of hazardous material...

  8. 48 CFR 942.705-4 - State and local governments.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... governments. 942.705-4 Section 942.705-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... governments. A list of cognizant agencies for State/local government organizations is periodically published... notified of such assignments. The current negotiated rates for State/local government activities...

  9. 48 CFR 942.705-4 - State and local governments.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... governments. 942.705-4 Section 942.705-4 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACT... governments. A list of cognizant agencies for State/local government organizations is periodically published... notified of such assignments. The current negotiated rates for State/local government activities...

  10. 48 CFR 252.241-7001 - Government access.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Government access. 252.241... Clauses 252.241-7001 Government access. As prescribed in 241.501-70(b), use the following clause: Government Access (DEC 1991) Authorized representatives of the Government may have access to the...

  11. 31 CFR 537.307 - Government of Burma.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Government of Burma. 537.307 Section 537.307 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF....307 Government of Burma. The term Government of Burma means the Government of Burma...

  12. 48 CFR 832.202-4 - Security for Government financing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Security for Government... for Government financing. An offeror's financial condition may be considered adequate security to protect the Government's interest when the Government provides contract financing. In assessing...

  13. 45 CFR 1607.4 - Functions of a governing body.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Functions of a governing body. 1607.4 Section 1607.4 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION GOVERNING BODIES § 1607.4 Functions of a governing body. (a) A governing body shall have at least four...

  14. 45 CFR 1607.4 - Functions of a governing body.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Functions of a governing body. 1607.4 Section 1607.4 Public Welfare Regulations Relating to Public Welfare (Continued) LEGAL SERVICES CORPORATION GOVERNING BODIES § 1607.4 Functions of a governing body. (a) A governing body shall have at least four...

  15. 48 CFR 52.251-1 - Government Supply Sources.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Government Supply Sources....251-1 Government Supply Sources. As prescribed in 51.107, insert the following clause in solicitations... services from a Government supply source: Government Supply Sources (AUG 2010) The Contracting Officer...

  16. 48 CFR 52.251-1 - Government Supply Sources.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Government Supply Sources....251-1 Government Supply Sources. As prescribed in 51.107, insert the following clause in solicitations... services from a Government supply source: Government Supply Sources (AUG 2010) The Contracting Officer...

  17. 48 CFR 42.1304 - Government delay of work.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Government delay of work... CONTRACT MANAGEMENT CONTRACT ADMINISTRATION AND AUDIT SERVICES Suspension of Work, Stop-Work Orders, and Government Delay of Work 42.1304 Government delay of work. (a) The clause at 52.242-17, Government Delay...

  18. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  19. 48 CFR 3045.505-14 - Reports of Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 7 2011-10-01 2011-10-01 false Reports of Government... Management of Government Property in the Possession of Contractors 3045.505-14 Reports of Government property... DHS Form 0700-05, Contractor Report of Government Property....

  20. 48 CFR 3045.505-14 - Reports of Government property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Reports of Government... Management of Government Property in the Possession of Contractors 3045.505-14 Reports of Government property... DHS Form 0700-05, Contractor Report of Government Property....

  1. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  2. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  3. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Report of Government... Contract Management GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  4. 48 CFR 2845.505-14 - Report of Government Property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Report of Government... CONTRACT MANAGEMENT GOVERNMENT PROPERTY Management of Government Property in the Possession of Contractors 2845.505-14 Report of Government Property. (a) In compliance with FAR 45.505-14, by January 31 of...

  5. Achieving Accelerated Cleanup of Cesium Contaminated Stream at the Savannah River Site; Collaboration between Stakeholders, Regulators, and the Federal Government - 13182

    SciTech Connect

    Bergren, Chris; Flora, Mary; Socha, Ron; Burch, Joseph; Freeman, Candice; Hennessey, Brian

    2013-07-01

    's stakeholders including the regulators, U. S. Environmental Protection Agency (US EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC), and the public including local property owners and the SRS Citizens Advisory Board. Stakeholder buy-in was critical in the up-front planning in order to achieve this challenging cleanup. (authors)

  6. New Shanghai laws to protect women, children. Shanghai regulations governing the protection of women and children [adopted by the Ninth Shanghai Municipal People's Congress Standing Committee, 15 February 1990].

    PubMed

    1990-02-28

    These regulations on the protection of women and children in Shanghai, China, do the following, among other things: 1) establish at all local government levels, including the neighborhood level, committees to protect women and children; 2) prohibit the abduction and trading of women, prostitution, patronage of prostitutes, pimping, and forcing women to engage in "obscene business;" 3) prohibit adultery and cohabitation; 4) provide that children should be the first to receive protection and be rescued on occasions when their lives are threatened; 5) prohibit the encroachment on or vandalization and destruction of children's recreational areas and child care facilities; and 6) prescribe reeducation, detention, and education through labor as penalties. The regulations also stipulate that women enjoy equal rights with men in education and work. When a unit recruits and hires workers, it may not reject women for jobs that they are capable of doing or create any conditions that discriminate against women. When a school enrolls students, it may not create any conditions that are prejudicial to female students.

  7. Local Governments (Executive Offices) Sector (NAICS 921110)

    EPA Pesticide Factsheets

    EPA regulatory information for government executive offices, including state implementation plans (SIPs), local emergency planning under EPCRA, drinking water treatment, water supply security, and compliance assistance for boiler & combustion regulations.

  8. 10 CFR 603.220 - Government participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Government participation. 603.220 Section 603.220 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of Technology Investment Agreements § 603.220 Government participation. A TIA is used to carry out...

  9. 10 CFR 603.220 - Government participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Government participation. 603.220 Section 603.220 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of Technology Investment Agreements § 603.220 Government participation. A TIA is used to carry out...

  10. 76 FR 75421 - Managing Government Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... requirements in law, regulation, and this memorandum is a priority for senior agency management; (ii) ensure... (Archivist), a senior agency official to supervise the review required by subsection (b) of this section, in...) increasing open Government and appropriate public access to Government records; (v) supporting...

  11. 78 FR 44459 - Tribal Self-Governance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service 42 CFR Part 137 Tribal Self-Governance CFR Correction In Title 42 of the Code of Federal Regulations, Parts 1 to 399, revised as of October 1, 2012, on page 932, in...

  12. 10 CFR 603.220 - Government participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Government participation. 603.220 Section 603.220 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of Technology Investment Agreements § 603.220 Government participation. A TIA is used to carry out...

  13. 10 CFR 603.220 - Government participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Government participation. 603.220 Section 603.220 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of Technology Investment Agreements § 603.220 Government participation. A TIA is used to carry out...

  14. 45 CFR 1304.50 - Program governance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... AGENCIES Program Design and Management § 1304.50 Program governance. (a) Policy Council, Policy Committee... regulations, the total size of their respective policy groups (based on the number of centers, classrooms or... in partnership with key management staff and the governing body to develop, review, and approve or...

  15. 45 CFR 1304.50 - Program governance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... AGENCIES Program Design and Management § 1304.50 Program governance. (a) Policy Council, Policy Committee... regulations, the total size of their respective policy groups (based on the number of centers, classrooms or... in partnership with key management staff and the governing body to develop, review, and approve or...

  16. 48 CFR 53.245 - Government property.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Government property. 53...) CLAUSES AND FORMS FORMS Prescription of Forms 53.245 Government property. The following forms are prescribed, as specified in this section, for use in reporting, reutilization, and disposal of...

  17. 48 CFR 53.245 - Government property.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Government property. 53...) CLAUSES AND FORMS FORMS Prescription of Forms 53.245 Government property. The following forms are prescribed, as specified in this section, for use in reporting, reutilization, and disposal of...

  18. 48 CFR 53.245 - Government property.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Government property. 53...) CLAUSES AND FORMS FORMS Prescription of Forms 53.245 Government property. The following forms are prescribed, as specified in this section, for use in reporting, reutilization, and disposal of...

  19. 48 CFR 53.245 - Government property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Government property. 53...) CLAUSES AND FORMS FORMS Prescription of Forms 53.245 Government property. The following forms are prescribed, as specified in this section, for use in reporting, reutilization, and disposal of...

  20. 10 CFR 603.220 - Government participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Government participation. 603.220 Section 603.220 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Appropriate Use of Technology Investment Agreements § 603.220 Government participation. A TIA is used to carry out...