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Sample records for grado nic ii-nic

  1. Ferrocenyl-phospho-nic acid.

    PubMed

    Yang, Bao-Zhang; Xu, Chao; Duan, Tai-Ke; Chen, Qun; Zhang, Qian-Feng

    2011-08-01

    In the title compound, [Fe(C(5)H(5))(C(5)H(6)O(3)P)], the phosphate group is bonded to the ferrocene unit with a P-C bond length of 1.749 (3) Å. In the crystal, six ferrocenyl-phospho-nic acid mol-ecules are connected by 12 strong inter-molecular O-H⋯O hydrogen bonds, leading to the formation of a highly distorted octa-hedral cage. The volume of the octa-hedral cage is about 270 Å(3).

  2. Microwave absorption properties of Ni/(C, silicides) nanocapsules

    PubMed Central

    2012-01-01

    The microwave absorption properties of Ni/(C, silicides) nanocapsules prepared by an arc discharge method have been studied. The composition and the microstructure of the Ni/(C, silicides) nanocapsules were determined by means of X-ray diffraction, X-ray photoelectric spectroscopy, and transmission electron microscope observations. Silicides, in the forms of SiOx and SiC, mainly exist in the shells of the nanocapsules and result in a large amount of defects at the ‘core/shell’ interfaces as well as in the shells. The complex permittivity and microwave absorption properties of the Ni/(C, silicides) nanocapsules are improved by the doped silicides. Compared with those of Ni/C nanocapsules, the positions of maximum absorption peaks of the Ni/(C, silicides) nanocapsules exhibit large red shifts. An electric dipole model is proposed to explain this red shift phenomenon. PMID:22548846

  3. Microwave absorption properties of Ni/(C, silicides) nanocapsules

    NASA Astrophysics Data System (ADS)

    Jiang, Jingjing; Wang, Han; Guo, Huaihong; Yang, Teng; Tang, Wen-Shu; Li, Da; Ma, Song; Geng, Dianyu; Liu, Wei; Zhang, Zhidong

    2012-05-01

    The microwave absorption properties of Ni/(C, silicides) nanocapsules prepared by an arc discharge method have been studied. The composition and the microstructure of the Ni/(C, silicides) nanocapsules were determined by means of X-ray diffraction, X-ray photoelectric spectroscopy, and transmission electron microscope observations. Silicides, in the forms of SiOx and SiC, mainly exist in the shells of the nanocapsules and result in a large amount of defects at the `core/shell' interfaces as well as in the shells. The complex permittivity and microwave absorption properties of the Ni/(C, silicides) nanocapsules are improved by the doped silicides. Compared with those of Ni/C nanocapsules, the positions of maximum absorption peaks of the Ni/(C, silicides) nanocapsules exhibit large red shifts. An electric dipole model is proposed to explain this red shift phenomenon.

  4. Microwave absorption properties of Ni/(C, silicides) nanocapsules.

    PubMed

    Jiang, Jingjing; Wang, Han; Guo, Huaihong; Yang, Teng; Tang, Wen-Shu; Li, Da; Ma, Song; Geng, Dianyu; Liu, Wei; Zhang, Zhidong

    2012-05-01

    The microwave absorption properties of Ni/(C, silicides) nanocapsules prepared by an arc discharge method have been studied. The composition and the microstructure of the Ni/(C, silicides) nanocapsules were determined by means of X-ray diffraction, X-ray photoelectric spectroscopy, and transmission electron microscope observations. Silicides, in the forms of SiOx and SiC, mainly exist in the shells of the nanocapsules and result in a large amount of defects at the 'core/shell' interfaces as well as in the shells. The complex permittivity and microwave absorption properties of the Ni/(C, silicides) nanocapsules are improved by the doped silicides. Compared with those of Ni/C nanocapsules, the positions of maximum absorption peaks of the Ni/(C, silicides) nanocapsules exhibit large red shifts. An electric dipole model is proposed to explain this red shift phenomenon.

  5. 75 FR 48365 - Solicitation for a Cooperative Agreement-NIC Cost Containment Online Resource Center Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... National Institute of Corrections Solicitation for a Cooperative Agreement--NIC Cost Containment Online...: Solicitation for cooperative agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting.... The NIC Cost Containment Online Resource Center (CCORC) will be housed on the NIC Web site and...

  6. Using NANDA, NIC, and NOC in an undergraduate nursing practicum.

    PubMed

    Smith, Kelly J; Craft-Rosenberg, Martha

    2010-01-01

    Although use of diagnoses originally developed by NANDA (now known as NANDA-I), NIC, and NOC in education and practice is increasing, many faculty members have not been educated in their use and may be reluctant to teach these languages. This article provides guidance on the use of NANDA-I, NIC, and NOC in clinical education. This guidance will facilitate both faculty and student learning.

  7. Stuttgart Interconnection Network Project from PIX to NICS

    NASA Technical Reports Server (NTRS)

    1984-01-01

    The PIX follow-up project NICS is described. The purpose of PIX was access to X.25, the DATEX-P network of the Federal German Post Office. The development and implementation of higher protocols for levels 4-7 in the ISOSINN was the actual problem here. Results of the PIX project are given. NICS (Stuttgart Interconnection Network Project) is presented. International Protocols are reviewed. PAD service is described, which allows terminal access to DATEX-P network of the Federal German Post Office.

  8. 40 CFR 63.1212 - What are the other requirements pertaining to the NIC?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... pertaining to the NIC? 63.1212 Section 63.1212 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 63.1212 What are the other requirements pertaining to the NIC? (a) Certification of intent to comply. The Notice of Intent to Comply (NIC) must contain the following certification signed and dated by...

  9. 77 FR 40911 - Solicitation for a Cooperative Agreement-Technical Assistance Site Management in NIC's Evidence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... Management in NIC's Evidence-Based Decision Making in Local Criminal Justice Systems Initiative AGENCY... Agreement. SUMMARY: The National Institute of Corrections (NIC) Community Services Division is soliciting proposals from organizations, groups, or individuals to enter into a cooperative agreement with NIC for...

  10. Competency profile for registered nurses: NIC in gerontological nursing.

    PubMed

    2009-01-01

    A number of RNs provide both direct care and leadership in geriatric-care facilities. In this specialized area of care, the contributions of the RN are not well recognized. In this issue, we focus on gerontological nursing and how NIC can be used to describe and communicate this highly specialized role.

  11. NIC-based Reduction Algorithms for Large-scale Clusters

    SciTech Connect

    Petrini, F; Moody, A T; Fernandez, J; Frachtenberg, E; Panda, D K

    2004-07-30

    Efficient algorithms for reduction operations across a group of processes are crucial for good performance in many large-scale, parallel scientific applications. While previous algorithms limit processing to the host CPU, we utilize the programmable processors and local memory available on modern cluster network interface cards (NICs) to explore a new dimension in the design of reduction algorithms. In this paper, we present the benefits and challenges, design issues and solutions, analytical models, and experimental evaluations of a family of NIC-based reduction algorithms. Performance and scalability evaluations were conducted on the ASCI Linux Cluster (ALC), a 960-node, 1920-processor machine at Lawrence Livermore National Laboratory, which uses the Quadrics QsNet interconnect. We find NIC-based reductions on modern interconnects to be more efficient than host-based implementations in both scalability and consistency. In particular, at large-scale--1812 processes--NIC-based reductions of small integer and floating-point arrays provided respective speedups of 121% and 39% over the host-based, production-level MPI implementation.

  12. Scalable NIC-based reduction on large-scale clusters

    SciTech Connect

    Moody, A.; Fernández, J. C.; Petrini, F.; Panda, Dhabaleswar K.

    2003-01-01

    Many parallel algorithms require effiaent support for reduction mllectives. Over the years, researchers have developed optimal reduction algonduns by taking inm account system size, dam size, and complexities of reduction operations. However, all of these algorithm have assumed the faa that the reduction precessing takes place on the host CPU. Modem Network Interface Cards (NICs) sport programmable processors with substantial memory and thus introduce a fresh variable into the equation This raises the following intersting challenge: Can we take advantage of modern NICs to implementJost redudion operations? In this paper, we take on this challenge in the context of large-scale clusters. Through experiments on the 960-node, 1920-processor or ASCI Linux Cluster (ALC) located at the Lawrence Livermore National Laboratory, we show that NIC-based reductions indeed perform with reduced latency and immed consistency over host-based aleorithms for the wmmon case and that these benefits scale as the system grows. In the largest configuration tested--1812 processors-- our NIC-based algorithm can sum a single element vector in 73 ps with 32-bi integers and in 118 with Mbit floating-point numnbers. These results represent an improvement, respeaively, of 121% and 39% with resvect w the {approx}roductionle vel MPI library

  13. Alfvénic tornadoes in a magnetized plasma

    NASA Astrophysics Data System (ADS)

    Shukla, P. K.

    2013-01-01

    It is shown that three-dimensional (3D) modified-kinetic Alfvén waves (m-KAWs) in a magnetized plasma can propagate in the form of Alfvénic tornadoes characterized by plasma density whirls or magnetic flux ropes carrying orbital angular momentum. By using the two-fluid model, together with Ampère's law, we derive the wave equation for 3D m-KAWs in a magnetoplasma with me/mi ≪ β ≪ 1, where me (mi) is the electron (ion) mass, β=4πn0kB (Te+Ti)/B02, n0 the unperturbed plasma number density, kB the Boltzmann constant, Te(Te) the electron (ion) temperature, and B0 the strength of the ambient magnetic field. The 3D m-KAW equation admits solutions in the form of a Laguerre-Gauss Alfvénic vortex beam or a twisted kinetic Alfvénic wave with plasma density whirls that support the dynamics of shear Alfvénic magnetic flux ropes in plasmas.

  14. Concerted action of NIC relaxase and auxiliary protein MobC in RA3 plasmid conjugation.

    PubMed

    Godziszewska, Jolanta; Moncalián, Gabriel; Cabezas, Matilde; Bartosik, Aneta A; de la Cruz, Fernando; Jagura-Burdzy, Grazyna

    2016-08-01

    Conjugative transfer of the broad-host-range RA3 plasmid, the archetype of the IncU group, relies on the relaxase NIC that belongs to the as yet uncharacterized MOBP4 subfamily. NIC contains the signature motifs of HUH relaxases involved in Tyr nucleophilic attack. However, it differs in the residue involved in His activation for cation coordination and was shown here to have altered divalent cation requirements. NIC is encoded in the mobC-nic operon preceded directly by oriT, where mobC encodes an auxiliary transfer protein with a dual function: autorepressor and stimulator of conjugative transfer. Here an interplay between MobC and NIC was demonstrated. MobC is required for efficient NIC cleavage of oriT in supercoiled DNA whereas NIC assists MobC in repression of the mobC-nic operon. A 7-bp arm of IR3 (IR3a) was identified as the binding site for NIC and the crucial nucleotides in IR3a for NIC recognition were defined. Fully active oriTRA3 was delineated to a 47-bp DNA segment encompassing a conserved cleavage site sequence, the NIC binding site IR3a and the MobC binding site OM . This highly efficient RA3 conjugative system with defined requirements for minimal oriT could find ample applications in biotechnology and computational biology where simple conjugative systems are needed.

  15. 77 FR 33000 - Solicitation for a Cooperative Agreement: Resources for NIC's Web Site on Data Collection and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-04

    ... National Institute of Corrections Solicitation for a Cooperative Agreement: Resources for NIC's Web Site on... Corrections (NIC) is seeking applications for the development of resources for NIC's Web site on data.... NIC currently has some content under development on its Web site at...

  16. Helping nurses use NANDA, NOC, and NIC: novice to expert.

    PubMed

    Lunney, Margaret

    2006-01-01

    The electronic health record (EHR) requires the use of standardized nursing languages such as NANDA, NOC, and NIC. Helping nurses use these languages for an EHR requires different educational strategies in 3 domains: intellectual, interpersonal, and technical. The author explains the rationale for changes in educational methods, expectations that educators and managers should set for students and nurses at various levels of expertise, and teaching strategies in each of the domains.

  17. Ag(nic)2 (nic = nicotinate): a spin-canted quasi-2D antiferromagnet composed of square-planar S = 1/2 Ag(II) ions.

    PubMed

    Manson, Jamie L; Woods, Toby J; Lapidus, Saul H; Stephens, Peter W; Southerland, Heather I; Zapf, Vivien S; Singleton, John; Goddard, Paul A; Lancaster, Tom; Steele, Andrew J; Blundell, Stephen J

    2012-02-20

    Square-planar S = 1/2 Ag(II) ions in polymeric Ag(nic)(2) are linked by bridging nic monoanions to yield 2D corrugated sheets. Long-range magnetic order occurs below T(N) = 11.8(2) K due to interlayer couplings that are estimated to be about 30 times weaker than the intralayer exchange interaction.

  18. Alfvénic fluctuations in ``newborn'' polar solar wind

    NASA Astrophysics Data System (ADS)

    Bavassano, B.; Pietropaolo, E.; Bruno, R.

    2005-06-01

    The 3-D structure of the solar wind is strongly dependent upon the Sun's activity cycle. At low solar activity a bimodal structure is dominant, with a fast and uniform flow at the high latitudes, and slow and variable flows at low latitudes. Around solar maximum, in sharp contrast, variable flows are observed at all latitudes. This last kind of pattern, however, is a relatively short-lived feature, and quite soon after solar maximum the polar wind tends to regain its role. The plasma parameter distributions for these newborn polar flows appear very similar to those typically observed in polar wind at low solar activity. The point addressed here is about polar wind fluctuations. As is well known, the low-solar-activity polar wind is characterized by a strong flow of Alfvénic fluctuations. Does this hold for the new polar flows too? An answer to this question is given here through a comparative statistical analysis on parameters such as total energy, cross helicity, and residual energy, that are of general use to describe the Alfvénic character of fluctuations. Our results indicate that the main features of the Alfvénic fluctuations observed in low-solar-activity polar wind have been quickly recovered in the new polar flows developed shortly after solar maximum. Keywords. Interplanetary physics (MHD waves and turbulence; Sources of the solar wind) Space plasma physics (Turbulence)

  19. The design and implementation of application level transparent firewall system based on NIC driver

    NASA Astrophysics Data System (ADS)

    Du, Xin; Xu, Yong

    2013-03-01

    On the analysis of the Intel 100 Mbps NIC driver, a scheme of implementing application level transparent firewall system using Intel 100 Mbps NIC driver was presented. Base on this scheme, the program can capture all network data packets through the NIC, analyze and process data according to the loaded rules and transmit packets. At the same time, this method can greatly improve the efficiency on depth analyzing network data in application-layer and rule matching.

  20. Quantitative determination of amorphous nicardipine hydrochloride in long acting formula (NIC-LA) using light anhydrous silicic acid.

    PubMed

    Kohinata, Takeru; Fujii, Mitsuo; Nakamura, Souichiro; Hamada, Noritaka; Yonemochi, Etsuo; Terada, Katsuhide

    2004-12-01

    We investigated a method to quantitatively determine amorphous nicardipine hydrochloride (NIC) in the NIC-long acting formula (LA) model formulas prepared using NIC, light anhydrous silicic acid (LASA) and carboxymethylethylcellulose (CMEC). Consequently, since the quantity of total NIC in the formula can be determined by means of HPLC and crystal NIC can be determined by the differential scanning calorimetry (DSC) method because the heat of fusion (85.08 J/g) of NIC is constant and unaffected by excipients, we developed the HPLC-DSC method by which the quantity of amorphous NIC is calculated as the difference between the quantity of total NIC determined by HPLC and the quantity of crystal NIC determined by DSC. This practical HPLC-DSC method was confirmed to have good accuracy and reproducibility.

  1. Complete Genome Sequence of Sphingomonas sp. Strain NIC1, an Efficient Nicotine-Degrading Bacterium

    PubMed Central

    Zhu, Xiongyu; Wang, Weiwei; Xu, Ping

    2016-01-01

    Sphingomonas sp. strain NIC1, an efficient nicotine-degrading bacterium, was isolated from tobacco leaves. Here, we present the complete genome sequence of strain NIC1, which contains one circular chromosome and two circular plasmids. The genomic information will provide insights into its molecular mechanism for nicotine degradation. PMID:27417841

  2. [Analysis of publications on Nursing Interventions Classification (NIC) from 1980 to 2004].

    PubMed

    Napoleão, Anamaria Alves; Chianca, Tânia Couto Machado; de Carvalho, Emília Campos; Dalri, Maria Célia Barcellos

    2006-01-01

    This study aimed at reviewing the knowledge produced about the Nursing Interventions Classification (NIC) available in the scientific literature from January 1980 to January 2004. NIC is a taxonomy with activities performed by nurses. Authors searched Lilacs and Medline databases, materials at the Center for Nursing Classification-University of Iowa College of Nursing and a doctoral dissertation obtained from a private library. The works found referred to the application of NIC to practice, the languages used in information systems, the use of NIC in these systems and the presentation, construction, development and validation of a taxonomy, among others. Authors concluded that there are several possibilities related to the production of knowledge on NIC in Brazil and that it is necessary to encourage studies on this taxonomy, raising questions and generating new knowledge to contribute to the improvement of Brazilian Nursing.

  3. Towards an integrated model of the NIC layered implosions

    NASA Astrophysics Data System (ADS)

    Jones, O.; Callahan, D.; Cerjan, C.; Clark, D.; Edwards, M. J.; Glenzer, S.; Marinak, M.; Meezan, N.; Milovich, J.; Olson, R.; Patel, M.; Robey, H.; Sepke, S.; Spears, B.; Springer, P.; Weber, S.; Wilson, D.

    2013-11-01

    A detailed simulation-based model of the June 2011 National Ignition Campaign (NIC) cryogenic DT experiments is presented. The model is based on integrated hohlraum-capsule simulations that utilize the best available models for the hohlraum wall, ablator, and DT equations of state and opacities. The calculated radiation drive was adjusted by changing the input laser power to match the experimentally measured shock speeds, shock merger times, peak implosion velocity, and bangtime. The crossbeam energy transfer model was tuned to match the measured time-dependent symmetry. Mid-mode mix was included by directly modeling the ablator and ice surface perturbations up to mode 60. Simulated experimental values were extracted from the simulation and compared against the experiment. The model adjustments brought much of the simulated data into closer agreement with the experiment, with the notable exception of the measured yields, which were 15-40% of the calculated yields.

  4. Towards an Integrated Model of the NIC Layered Implosions

    SciTech Connect

    Jones, O S; Callahan, D A; Cerjan, C J; Clark, D S; Edwards, M J; Glenzer, S H; Marinak, M M; Meezan, N B; Milovich, J L; Olson, R E; Patel, M V; Robey, H F; Sepke, S M; Spears, B K; Springer, P T; Weber, S V; Wilson, D C

    2011-10-31

    A detailed simulation-based model of the June 2011 National Ignition Campaign (NIC) cryogenic DT experiments is presented. The model is based on integrated hohlraum-capsule simulations that utilize the best available models for the hohlraum wall, ablator, and DT equations of state and opacities. The calculated radiation drive was adjusted by changing the input laser power to match the experimentally measured shock speeds, shock merger times, peak implosion velocity, and bangtime. The crossbeam energy transfer model was tuned to match the measured time-dependent symmetry. Mid-mode mix was included by directly modeling the ablator and ice surface perturbations up to mode 60. Simulated experimental values were extracted from the simulation and compared against the experiment. The model adjustments brought much of the simulated data into closer agreement with the experiment, with the notable exception of the measured yields, which were 15-45% of the calculated yields.

  5. How to catch a parasite: Parasite Niche Modeler (PaNic) meets Fishbase

    USGS Publications Warehouse

    Strona, Giovanni; Lafferty, Kevin D.

    2012-01-01

    Parasite Niche Modeler (PaNic) is a free online software tool that suggests potential hosts for fish parasites. For a particular parasite species from the major helminth groups (Acanthocephala, Cestoda, Monogenea, Nematoda, Trematoda), PaNic takes data from known hosts (maximum body length, growth rate, life span, age at first maturity, trophic level, phylogeny, and biogeography) and hypothesizes similar fish species that might serve as hosts to that parasite. Users can give varying weights to host attributes and create custom models. In addition to suggesting plausible hosts (with varying degrees of confidence), the models indicate known host species that appear to be outliers in comparison to other known hosts. These unique features make PaNic an innovative tool for addressing both theoretical and applied questions in fish parasitology. PaNic can be accessed at .

  6. Silicon-Class Ablators for NIC Ignition Capsules

    NASA Astrophysics Data System (ADS)

    Ho, Darwin; Salmonson, Jay; Haan, Steve

    2012-10-01

    We present design studies using silicon-class ablators (i.e., Si, SiC, SiB6, and SiB14) for NIC ignition capsules. These types of ablators have several advantages in that they: (a) require no internal dopant layers and are robust to M-band radiation; (b) have smooth outer surfaces; (c) have stable fuel-ablator interface; and (d) have good 1-D performance. The major disadvantage for some of the ablators in this class is the relatively smaller ablation stabilization. Consequently, the ablator is more susceptible to breakup caused by RT instabilities. However, smoother outer surfaces on this class of ablators can reduce the effect of RT instabilities. 2-D simulations of SiC ablators show ignition failure despite smooth surfaces and good 1-D performance. But SiB6 and SiB14 ablators exhibit promising behaviors. SiB6 (SiB14) ablators have high 1-D ignition margin and high peak core hydrodynamic pressure 880 (900) Gbar. The ablation scale length for SiB6 is longer than that for SiC and for SiB14 is comparable to that of plastic. Therefore, we expect acceptable performance for SiB6 and less RT growth for SiB14. 2-D simulations are now in progress.

  7. An Offload NIC for NASA, NLR, and Grid Computing

    NASA Technical Reports Server (NTRS)

    Awrach, James

    2013-01-01

    This work addresses distributed data management and access dynamically configurable high-speed access to data distributed and shared over wide-area high-speed network environments. An offload engine NIC (network interface card) is proposed that scales at nX10-Gbps increments through 100-Gbps full duplex. The Globus de facto standard was used in projects requiring secure, robust, high-speed bulk data transport. Novel extension mechanisms were derived that will combine these technologies for use by GridFTP, bandwidth management resources, and host CPU (central processing unit) acceleration. The result will be wire-rate encrypted Globus grid data transactions through offload for splintering, encryption, and compression. As the need for greater network bandwidth increases, there is an inherent need for faster CPUs. The best way to accelerate CPUs is through a network acceleration engine. Grid computing data transfers for the Globus tool set did not have wire-rate encryption or compression. Existing technology cannot keep pace with the greater bandwidths of backplane and network connections. Present offload engines with ports to Ethernet are 32 to 40 Gbps f-d at best. The best of ultra-high-speed offload engines use expensive ASICs (application specific integrated circuits) or NPUs (network processing units). The present state of the art also includes bonding and the use of multiple NICs that are also in the planning stages for future portability to ASICs and software to accommodate data rates at 100 Gbps. The remaining industry solutions are for carrier-grade equipment manufacturers, with costly line cards having multiples of 10-Gbps ports, or 100-Gbps ports such as CFP modules that interface to costly ASICs and related circuitry. All of the existing solutions vary in configuration based on requirements of the host, motherboard, or carriergrade equipment. The purpose of the innovation is to eliminate data bottlenecks within cluster, grid, and cloud computing systems

  8. Investigating Alfvénic wave propagation in coronal open-field regions.

    PubMed

    Morton, R J; Tomczyk, S; Pinto, R

    2015-01-01

    The physical mechanisms behind accelerating solar and stellar winds are a long-standing astrophysical mystery, although recent breakthroughs have come from models invoking the turbulent dissipation of Alfvén waves. The existence of Alfvén waves far from the Sun has been known since the 1970s, and recently the presence of ubiquitous Alfvénic waves throughout the solar atmosphere has been confirmed. However, the presence of atmospheric Alfvénic waves does not, alone, provide sufficient support for wave-based models; the existence of counter-propagating Alfvénic waves is crucial for the development of turbulence. Here, we demonstrate that counter-propagating Alfvénic waves exist in open coronal magnetic fields and reveal key observational insights into the details of their generation, reflection in the upper atmosphere and outward propagation into the solar wind. The results enhance our knowledge of Alfvénic wave propagation in the solar atmosphere, providing support and constraints for some of the recent Alfvén wave turbulence models. PMID:26213234

  9. Investigating Alfvénic wave propagation in coronal open-field regions

    PubMed Central

    Morton, R. J.; Tomczyk, S.; Pinto, R.

    2015-01-01

    The physical mechanisms behind accelerating solar and stellar winds are a long-standing astrophysical mystery, although recent breakthroughs have come from models invoking the turbulent dissipation of Alfvén waves. The existence of Alfvén waves far from the Sun has been known since the 1970s, and recently the presence of ubiquitous Alfvénic waves throughout the solar atmosphere has been confirmed. However, the presence of atmospheric Alfvénic waves does not, alone, provide sufficient support for wave-based models; the existence of counter-propagating Alfvénic waves is crucial for the development of turbulence. Here, we demonstrate that counter-propagating Alfvénic waves exist in open coronal magnetic fields and reveal key observational insights into the details of their generation, reflection in the upper atmosphere and outward propagation into the solar wind. The results enhance our knowledge of Alfvénic wave propagation in the solar atmosphere, providing support and constraints for some of the recent Alfvén wave turbulence models. PMID:26213234

  10. Alfvénic waves in polar spicules

    NASA Astrophysics Data System (ADS)

    Tavabi, E.; Koutchmy, S.; Ajabshirizadeh, A.; Ahangarzadeh Maralani, A. R.; Zeighami, S.

    2015-01-01

    Context. For investigating spicules from the photosphere to coronal heights, the new Hinode/SOT long series of high-resolution observations from space taken in CaII H line emission offers an improved way to look at their remarkable dynamical behavior using images free of seeing effects. They should be put in the context of the huge amount of already accumulated material from ground-based instruments, including high- resolution spectra of off-limb spicules. Aims: Both the origin of the phenomenon and the significance of dynamical spicules for the heating above the top of the photosphere and the fuelling of the chromospheric and the transition region need more investigation, including of the possible role of the associated magnetic waves for the corona higher up. Methods: We analyze in great detail the proper transverse motions of mature and tall polar region spicules for different heights, assuming that there might be Helical-Kink waves or Alfvénic waves propagating inside their multicomponent substructure, by interpreting the quasi-coherent behavior of all visible components presumably confined by a surrounding magnetic envelop. We concentrate the analysis on the taller CaII spicules more relevant for coronal heights and easier to measure. Two-dimensional velocity maps of proper motion were computed for the first time using a correlation tracking technique based on FFTs and cross-correlation function with a 2nd-order-accuracy Taylor expansion. Highly processed images with the popular mad-max algorithm were first prepared to perform this analysis. The locations of the peak of the cross-correlation function were obtained with subpixel accuracy. Results: The surge-like behavior of solar polar region spicules supports the untwisting multicomponent interpretation of spicules exhibiting helical dynamics. Several tall spicules are found with (i) upward and downward flows that are similar at lower and middle levels, the rate of upward motion being slightly higher at high

  11. Using NicAlert Strips to Validate Smoking Status Among Pregnant Cigarette Smokers

    PubMed Central

    Gaalema, Diann E.; Higgins, Stephen T.; Bradstreet, Matthew P.; Heil, Sarah H.; Bernstein, Ira M.

    2011-01-01

    Background Decreasing smoking during pregnancy is an important public health priority. An important step towards decreasing smoking during pregnancy is wider dissemination of evidence-based smoking cessation interventions. One such intervention is contingency management wherein mothers earn vouchers exchangeable for retail items contingent on biochemically-verified smoking abstinence. Wider dissemination may be possible by using smoking verification methods that require minimal training and equipment. One possibility is to use a cotinine-sensitive dipstick (NicAlert) rather than a bench-top cotinine analyzer, which is expensive and requires relatively extensive technician expertise, or breath carbon monoxide analysis, which is relatively nonspecific. The present study was conducted to begin examining the utility of cotinine-sensitive dipsticks for this purpose. Methods Fifty urine samples from pregnant women enrolled in a smoking cessation program were analyzed to compare three different methods for verifying smoking status: NicAlert strips, a bench-top enzyme multiplied immunoassay technique (EMIT) analyzer, and gas chromatography (GC), the current gold standard for determining cotinine levels in urine. Results Agreement between GC and NicAlert results were high (96%) and comparable to agreement between GC and EMIT results (94%). Semi-quantitative measurements using NicAlert were low with only 30% of samples in agreement between GC and specific ranges given on the strips. Conclusions NicAlert strips appear to be a valid measure of determining smoking status among pregnant smokers although not of absolute cotinine concentration. With minimal training and equipment required, NicAlert strips provide a potentially practical method for using urine cotinine to verify smoking status in community treatment settings. PMID:21652155

  12. Nursing documentation with NANDA and NIC in a comprehensive HIS/EPR system.

    PubMed

    Flø, Kåre

    2006-01-01

    DIPS nursing documentation system facilitates that nurses can write several types of notes into the EPR. Within these notes the nurses can register NANDA diagnoses and NIC interventions with nursing activities. To choose NANDA and NIC the nurse can use a search engine, or she can choose a relevant Care plan guideline and pick the suggested diagnoses and interventions from there. Diagnoses and interventions with nursing activities registered are presented in a Care plan. When a nurse writes a note for a patient she will always be presented the Care plan and she can easy evaluate and update the Care plan.

  13. Experimental study of collisionless super-Alfvénic interaction of interpenetrating plasma flows

    SciTech Connect

    Shaikhislamov, I. F. Zakharov, Yu. P.; Posukh, V. G.; Melekhov, A. V.; Boyarintsev, E. L.; Ponomarenko, A. G.; Terekhin, V. A.

    2015-05-15

    An experiment on the interaction between an expanding super-Alfvénic laser-produced plasma flow and a magnetized background plasma under conditions in which the ion gyroradius is comparable with the characteristic scale length of magnetic field displacement is described. The depletion of the background plasma in a substantial volume and the formation of a large-amplitude compression pulse propagating with a super-Alfvénic velocity are revealed. The efficiency of energy conversion into perturbations of the background plasma was found to be 25%. Combined data from magnetic, electric, and plasma measurements indicate that the interaction occurs via the magnetic laminar mechanism.

  14. Application of Nursing Interventions Classification (NIC) in a cardiovascular critical care unit.

    PubMed

    Robbins, B T

    1997-01-01

    The nursing profession is moving toward developing a standardized language. Benefits of such a language are outlined. Nursing Interventions Classification (NIC) (Iowa Intervention Project, 1992), a standardized language for nursing interventions, has been recently developed by the Iowa Intervention Project. This article describes how NIC was incorporated into a nursing care plan in a tertiary acute care facility. Teaching strategies, which include aspects of adult learning theory and motivational theory, are discussed. Utilization of creativity and variability in the planning and implementation of a unit based inservice program were the most beneficial strategies used.

  15. Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta.

    PubMed

    Nekhayeva, Ilona A; Nanovskaya, Tatiana N; Pentel, Paul R; Keyler, Dan E; Hankins, Gary D V; Ahmed, Mahmoud S

    2005-11-25

    The adverse effects of smoking during pregnancy on fetal development are, in part, due to nicotine. These effects may be due to the actions of nicotine in fetal circulation or on placental functions. In pregnant rats, vaccination with a nicotine immunogen reduces the transfer of nicotine from the maternal to fetal circulation. However, extrapolation of these results to pregnant women might not be valid due to the well-recognized differences between human and rat placentas. In the current investigation, the effects of nicotine-specific antibodies on the transfer of nicotine from the maternal to fetal circuit of the dually perfused human placental lobule were determined. Two types of nicotine-specific antibodies were investigated; nicotine-specific mouse monoclonal antibody (Nic311, K(d) for nicotine 60nM) and IgG from rabbits vaccinated with a nicotine immunogen (Nic-IgG, K(d) 1.6nM). Transfer of the antibodies from maternal to fetal circuits was negligible. Both rabbit Nic-IgG and, to a lesser extent, mouse monoclonal Nic311 significantly reduced nicotine transfer from the maternal to fetal circuit as well as the retention of the drug by placental tissue. These effects were mediated by a substantial increase in the protein binding of nicotine and a reduction in the unbound nicotine concentration. Therefore, the data cited in this report suggest that the use of nicotine-specific antibodies might reduce fetal exposure to the drug, and that antibody affinity for nicotine is a key determinant of the extent of nicotine transfer.

  16. Complexes trans-[RuCl(2)(nic)(4)] and trans-[RuCl(2)(i-nic)(4)] as free radical scavengers.

    PubMed

    Creczynski-Pasa, T B; Bonetti, V R; Beirith, A; Ckless, K; Konzen, M; Seifriz, I; Paula, M S; Franco, C V; Wilhelm Filho, D; Calixto, J B

    2001-09-01

    This study evaluates the action of the new ruthenium complexes trans-RuCl(2)(nic)(4)] (I) and trans-[RuCl(2)(i-nic)(4)] (II) as free radical scavengers. In our experiments, both compounds acted as scavengers of superoxide anion (O(2)*(-)), hydroxyl radicals (HO*) and nitrogen monoxide (formally known as 'nitric oxide'; NO*). In addition, complexes I and II potentiated the release of NO* from S-nitroso-N-acetyl-DL-penicilamine (SNAP), a NO* donor. Complex II, but not I, also decreased the nitrite levels in culture media of activated macrophages. A hypsochromic shift of lambda(max) and a significant change in half-wave potential (E(1/2)) was observed when NO* was added to the Complex II. Thiobarbituric reactive substance (TBARS) levels were significantly reduced in rats treated for 1 week with Complex II plus tert-butylhydroperoxide, when compared to rats treated only with tert-butylhydroperoxide. None of the complexes showed cytotoxicity. These findings support the suggestion that the new ruthenium complexes, especially trans-[RuCl(2)(i-nic)(4)] or its derivatives, might provide potential therapeutic benefits in disorders where reactive nitrogen (RNS) or oxygen (ROS) species are involved.

  17. Statistical evidence for the existence of Alfvénic turbulence in solar coronal loops

    SciTech Connect

    Liu, Jiajia; McIntosh, Scott W.; Bethge, Christian; De Moortel, Ineke; Threlfall, James

    2014-12-10

    Recent observations have demonstrated that waves capable of carrying large amounts of energy are ubiquitous throughout the solar corona. However, the question of how this wave energy is dissipated (on which timescales and length scales) and released into the plasma remains largely unanswered. Both analytic and numerical models have previously shown that Alfvénic turbulence may play a key role not only in the generation of the fast solar wind, but in the heating of coronal loops. In an effort to bridge the gap between theory and observations, we expand on a recent study by analyzing 37 clearly isolated coronal loops using data from the Coronal Multi-channel Polarimeter instrument. We observe Alfvénic perturbations with phase speeds which range from 250 to 750 km s{sup –1} and periods from 140 to 270 s for the chosen loops. While excesses of high-frequency wave power are observed near the apex of some loops (tentatively supporting the onset of Alfvénic turbulence), we show that this excess depends on loop length and the wavelength of the observed oscillations. In deriving a proportional relationship between the loop length/wavelength ratio and the enhanced wave power at the loop apex, and from the analysis of the line widths associated with these loops, our findings are supportive of the existence of Alfvénic turbulence in coronal loops.

  18. Case Study IV: Carnegie Foundation for the Advancement of Teaching's Networked Improvement Communities (NICs)

    ERIC Educational Resources Information Center

    Coburn, Cynthia E.; Penuel, William R.; Geil, Kimberly E.

    2015-01-01

    The Carnegie Foundation for the Advancement of Teaching is a nonprofit, operating foundation with a long tradition of developing and studying ways to improve teaching practice. For the past three years, the Carnegie Foundation has initiated three different Networked Improvement Communities (NICs). The first, Quantway, is addressing the high…

  19. Alfvénic instabilities driven by runaways in fusion plasmas

    SciTech Connect

    Fülöp, T.; Newton, S.

    2014-08-15

    Runaway particles can be produced in plasmas with large electric fields. Here, we address the possibility that such runaway ions and electrons excite Alfvénic instabilities. The magnetic perturbation induced by these modes can enhance the loss of runaways. This may have important implications for the runaway electron beam formation in tokamak disruptions.

  20. 27 CFR 478.131 - Firearms transactions not subject to a NICS check.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2014-04-01 2014-04-01 false Firearms transactions not subject to a NICS check. 478.131 Section 478.131 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE IN FIREARMS...

  1. 27 CFR 478.131 - Firearms transactions not subject to a NICS check.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2013-04-01 2013-04-01 false Firearms transactions not subject to a NICS check. 478.131 Section 478.131 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE IN FIREARMS...

  2. 27 CFR 478.131 - Firearms transactions not subject to a NICS check.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Firearms transactions not subject to a NICS check. 478.131 Section 478.131 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE IN FIREARMS...

  3. 27 CFR 478.131 - Firearms transactions not subject to a NICS check.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Firearms transactions not subject to a NICS check. 478.131 Section 478.131 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE IN FIREARMS...

  4. 27 CFR 478.131 - Firearms transactions not subject to a NICS check.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2012-04-01 2010-04-01 true Firearms transactions not subject to a NICS check. 478.131 Section 478.131 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES, DEPARTMENT OF JUSTICE FIREARMS AND AMMUNITION COMMERCE IN FIREARMS...

  5. 78 FR 23872 - HIPAA Privacy Rule and the National Instant Criminal Background Check System (NICS)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ... mental health prohibitor, demographic information such as dates of birth, and codes identifying the... or others or being incapable of managing their own affairs (referred to below as the ``mental health... individuals subject to the mental health prohibitor ] to the NICS. The Department of Health and Human...

  6. Theoretical calculation and experiment of microwave electromagnetic property of Ni(C) nanocapsules

    NASA Astrophysics Data System (ADS)

    Dan-Feng, Zhang; Zhi-Feng, Hao; Bi, Zeng; Yan-Nan, Qian; Ying-Xin, Huang; Zhen-Da, Yang

    2016-04-01

    With the combination of the dielectric loss of the carbon layer with the magnetic loss of the ferromagnetic metal core, carbon-coated nickel (Ni(C)) nanoparticles are expected to be the promising microwave absorbers. Microwave electromagnetic parameters and reflection loss in a frequency range of 2 GHz-18 GHz for paraffin-Ni(C) composites are investigated. The values of relative complex permittivity and permeability, the dielectric and magnetic loss tangent of paraffin-Ni(C) composites are measured, respectively, when the weight ratios of Ni(C) nanoparticles are equal to 10 wt%, 40 wt%, 50 wt%, 70 wt%, and 80 wt% in paraffin-Ni(C) composites. The results reveal that Ni(C) nanoparticles exhibit a peak of magnetic loss at about 13 GHz, suggesting that magnetic loss and a natural resonance could be found at that frequency. Based on the measured complex permittivity and permeability, the reflection losses of paraffin-Ni(C) composites with different weight ratios of Ni(C) nanoparticles and coating thickness values are simulated according to the transmission line theory. An excellent microwave absorption is obtained. To be proved by the experimental results, the reflection loss of composite with a coating thickness of 2 mm is measured by the Arch method. The results indicate that the maximum reflection loss reaches -26.73 dB at 12.7 GHz, and below -10 dB, the bandwidth is about 4 GHz. The fact that the measured absorption position is consistent with the calculated results suggests that a good electromagnetic match and a strong microwave absorption can be established in Ni(C) nanoparticles. The excellent Ni(C) microwave absorber is prepared by choosing an optimum layer number and the weight ratio of Ni(C) nanoparticles in paraffin-Ni(C) composites. Project supported by the Science and Technology Program of Guangdong Province, China (Grant Nos. 2014B010106005, 2013B051000077, and 2015A050502047) and the Science and Technology Program of Guangzhou City, China (Grant No

  7. Some aspects of using the Hyperchem software in study of Ni-C nanostructures

    NASA Astrophysics Data System (ADS)

    Belka, Radoslaw; Piwowarczyk, Karol

    2010-09-01

    Ni-C nanostructures are the interesting object of study due to their potential use in field-effect electron emitters. Investigations of the structures are typically carried out using experimental methods as molecular spectroscopy (FTIR and Raman). The aim of these investigations is study the influence of metal atoms on formation of carbon structure. These studies may be expanded through the using of quantum mechanics calculation software. Some aspects of using a Hyperchem software in study of Ni-C structures will be presented. The simulations were made for typical structures of carbon (C60 fulleren and graphene) surrounded by metal atoms. The usefulness of the software in the quantum-mechanics calculations is analysed.

  8. Stellar winds and planetary bodies simulations: Lunar type interaction in super-Alfvénic and sub-Alfvénic flows

    NASA Astrophysics Data System (ADS)

    Vernisse, Y.; Kriegel, H.; Wiehle, S.; Motschmann, U.; Glassmeier, K.-H.

    2013-08-01

    Exoplanets are a place of numerous new effects in plasma physics and raise interest in extra-solar physics. Mainly specific cases of plasma interaction between planets, moons and the solar wind have been studied up to now, using data from observations within our solar system. A systematic description of the plasma interactions with respect to the properties of the stellar wind has not been made yet. In order to begin a systematization of the interactions, we study the lunar type plasma interaction by means of the A.I.K.E.F. simulation code, based on the hybrid model. By numerical derivation of MHD wave mode propagation, we show that the lunar wake expansion is governed by the MHD modes. Furthermore, the wake structure can be described by analyzing the different types of currents flowing around the lunar wake and assigning each current to the modes triggered by the obstacle. We show that most of the currents present in the lunar type interaction are a diamagnetic or a polarization current. This method has been also applied for results concerning the evolution of the lunar plasma structure by modifying the upstream velocity, with a transition from a super-Alfénic velocity to a sub-Alfvénic regime. The stellar wind transition study shows that the current switches from a horizontal structure where the current is mostly concentrated in the equatorial plane to a vertical structure where the current is mostly distributed along the magnetic field lines.

  9. Forumclínic: the shaping of virtual communities to assist patients with chronic diseases.

    PubMed

    Grau, Immaculada; Grajales Iii, Francisco J; Gene-Badia, Joan; Siso, Antoni; de Semir, Marc

    2013-01-01

    Information and communication technologies (ICTs) provide new opportunities to complement traditional care while enhancing patient autonomy. With the objective to supplement patient care, a group of health professionals at the Hospital Clínic de Barcelona created Forumclínic, an online networking website in Spanish and Catalan. In 2008, seven web- and DVD-based chronic disease portals (Diabetes, Schizophrenia, Cardiac Ischemia, COPD, Depression, Breast Cancer and cardiovascular risk) were created with the following resources: multimedia patient education material; physician-specialist transcribed research (articles) news; an open question forum (for clinician-user and user-to-user interaction); and patient and specialist interview videos on the progress of disease, common diagnosis and treatment procedures; and information on the best or worst prognoses. Using data from Google Analytics, server logs were used to observe online behaviour patterns and user postings. This data combined with a mixed methods approach were used to evaluate the development of a virtual community (VC). A virtual community was developed when the number of forum visits was greater than those in the disease portal (definition). While nearly half of the visitors were from the Americas, the Schizophrenia, Breast Cancer, Depression and COPD forums met the criteria for and developed a virtual community. However, the Diabetes and Cardiac Ischemia forums did not reach VC status. It is also interesting to note that users in their late thirties and early forties were primarily women. The development of four virtual communities in Forumclínic seems to support the self-care needs of virtual patients. Users also reported appreciating the increased interaction with experts online and commonly collaborated with the forum moderator to guide and support other users with similar conditions in managing their health. Thence, we believe that Forumclínic is a good model to complement traditional patient care

  10. Forumclínic: the shaping of virtual communities to assist patients with chronic diseases.

    PubMed

    Grau, Immaculada; Grajales Iii, Francisco J; Gene-Badia, Joan; Siso, Antoni; de Semir, Marc

    2013-01-01

    Information and communication technologies (ICTs) provide new opportunities to complement traditional care while enhancing patient autonomy. With the objective to supplement patient care, a group of health professionals at the Hospital Clínic de Barcelona created Forumclínic, an online networking website in Spanish and Catalan. In 2008, seven web- and DVD-based chronic disease portals (Diabetes, Schizophrenia, Cardiac Ischemia, COPD, Depression, Breast Cancer and cardiovascular risk) were created with the following resources: multimedia patient education material; physician-specialist transcribed research (articles) news; an open question forum (for clinician-user and user-to-user interaction); and patient and specialist interview videos on the progress of disease, common diagnosis and treatment procedures; and information on the best or worst prognoses. Using data from Google Analytics, server logs were used to observe online behaviour patterns and user postings. This data combined with a mixed methods approach were used to evaluate the development of a virtual community (VC). A virtual community was developed when the number of forum visits was greater than those in the disease portal (definition). While nearly half of the visitors were from the Americas, the Schizophrenia, Breast Cancer, Depression and COPD forums met the criteria for and developed a virtual community. However, the Diabetes and Cardiac Ischemia forums did not reach VC status. It is also interesting to note that users in their late thirties and early forties were primarily women. The development of four virtual communities in Forumclínic seems to support the self-care needs of virtual patients. Users also reported appreciating the increased interaction with experts online and commonly collaborated with the forum moderator to guide and support other users with similar conditions in managing their health. Thence, we believe that Forumclínic is a good model to complement traditional patient care

  11. Theoretical study of the solvent effect on the aromaticity of benzene: a NICS analysis.

    PubMed

    Junqueira, Georgia M A; Dos Santos, Hélio F

    2014-03-01

    Nucleus-independent chemical shift (NICS) quantities for benzene-benzene and benzene-water species were obtained and are discussed in gas phase and in solution. Besides standard polarizable continuum model (PCM) calculations, sequential Monte Carlo/quantum mechanics (S-MC/QM) were also performed. Benzene was shown to be slightly more aromatic in condensate phase when we considered the average solvent configuration (ASEC) approach with explicit molecules.

  12. The range of Alfvénic turbulence scales in the topside auroral ionosphere

    NASA Astrophysics Data System (ADS)

    Golovchanskaya, I. V.; Kozelov, B. V.

    2016-01-01

    The minimal scale of the Alfvénic turbulence transverse to the external magnetic field in the topside auroral ionosphere is investigated using electric field observations of the FAST spacecraft (the resolution 512 s-1). The events in which the power law form of the electric fluctuation spectra with a 2.0-2.5 slope (typical of Alfvénic turbulence) remains unchanged down to acoustic gyroradius ρs or ion gyroradius ρi local values are illustrated for the first time. In this case, the character of spectrum variation does not change at the electron inertial length λe, which is much larger than ρs and ρi for FAST altitudes (apogee ~4000 km). We have tried to explain this experimental fact by consideration of the known scenarios of the appearance of a small transverse scale in an Alfvénic perturbation. It has been noted that the effects of front steepening in an inertial Alfvén wave with a finite amplitude, which propagates at an angle smaller than (me/mi)1/2 with respect to the transverse direction, can result in small transverse scales comparable with acoustic gyroradius appearing in a perturbation.

  13. Evaluation of the aromaticity of non-planar and bowl-shaped molecules by NICS criterion.

    PubMed

    Reisi-Vanani, Adel; Rezaei, Ali Asghar

    2015-09-01

    Nucleus independent chemical shift (NICS) criterion was used to gauge the amount of aromaticity in a lot of publications in two last decades. Non-planar molecules with many polygons in different sheets that make angle together have not been studied by this criterion. Perhaps, one ascribes this deficiency to NICS index, but we think it is concern to depauperation in evaluation methods. Therefore, in this work, we try to evaluate aromaticity of two fullerene substructures bowl-shaped molecules, namely corannulene and sumanene as typical non-planar molecules by using of the NICSzz-scan method. The gauge-independent atomic orbital (GIAO) NMR calculations were done at B3LYP/6-311+G(d) level of theory. Energetic criterion as another tool for evaluation of the aromaticity of compounds was used and discussed. Results shows that pentagon and hexagon rings in corannulene have antiaromatic and aromatic character, respectively and in sumanene, pentagon and outer hexagon rings have antiaromatic and aromatic character, respectively. However, the picture obtained based on the NICS computations did not provide any insight towards the real nature of current density in the corannulene and sumanene. PMID:26188797

  14. Operational Use of Near Real Time Remote sensing Data at the U.S. National Ice Center (NIC)

    NASA Astrophysics Data System (ADS)

    Clemente-Colon, P.

    2012-12-01

    The National Ice Center (NIC) is a U.S. Government agency that brings together the Department of Defense - Navy, Department of Commerce - National Oceanic and Atmospheric Administration (NOAA), and the Department of Homeland Security - U.S. Coast Guard (USCG) to support coastal and marine sea ice operations and research in the Polar Regions. The NIC provides specialized strategic and tactical ice analyses to meet the operational needs of the U.S. government and is the only operational ice service in the world that monitors sea ice in both the Arctic, Antarctic regions as well as in other ice infested waters. NIC utilizes multiple sources of near real time satellite and in-situ observations as well as NWP and ocean-sea ice model output to produce sea ice analyses. Key users of NIC products in the Arctic include the Navy submarine force, National Weather Service, USCG and Canadian Coast Guard icebreakers, Military Sealift Command on re-supply missions to Antarctica and Greenland, and NOAA research vessels operating near sea ice cover in both hemispheres as well. Time series of NIC weekly or bi-weekly ice analysis charts, daily marginal ice zone and ice edge routine products, as well as tactical support annotated imagery are generated by expert analysts with wide access to near real time satellite imagery from VIS/IR to passive and active microwave sensors. The status of these satellite data streams and the expected availability of new capabilities in the near future will be discussed.

  15. Detection of cyclin D1 mRNA by hybridization sensitive NIC-oligonucleotide probe.

    PubMed

    Kovaliov, Marina; Segal, Meirav; Kafri, Pinhas; Yavin, Eylon; Shav-Tal, Yaron; Fischer, Bilha

    2014-05-01

    A large group of fluorescent hybridization probes, includes intercalating dyes for example thiazole orange (TO). Usually TO is coupled to nucleic acids post-synthetically which severely limits its use. Here, we have developed a phosphoramidite monomer, 10, and prepared a 2'-OMe-RNA probe, labeled with 5-(trans-N-hexen-1-yl-)-TO-2'-deoxy-uridine nucleoside, dU(TO), (Nucleoside bearing an Inter-Calating moiety, NIC), for selective mRNA detection. We investigated a series of 15-mer 2'-OMe-RNA probes, targeting the cyclin D1 mRNA, containing one or several dU(TO) at various positions. dU(TO)-2'-OMe-RNA exhibited up to 7-fold enhancement of TO emission intensity upon hybridization with the complementary RNA versus that of the oligomer alone. This NIC-probe was applied for the specific detection of a very small amount of a breast cancer marker, cyclin D1 mRNA, in total RNA extract from cancerous cells (250 ng/μl). Furthermore, this NIC-probe was found to be superior to our related NIF (Nucleoside with Intrinsic Fluorescence)-probe which could detect cyclin D1 mRNA target only at high concentrations (1840 ng/μl). Additionally, dU(T) can be used as a monomer in solid-phase oligonucleotide synthesis, thus avoiding the need for post-synthetic modification of oligonucleotide probes. Hence, we propose dU(TO) oligonucleotides, as hybridization probes for the detection of specific RNA in homogeneous solutions and for the diagnosis of breast cancer.

  16. Generation of Alfvénic waves and turbulence in reconnection jets

    NASA Astrophysics Data System (ADS)

    Hoshino, Masahiro; Higashimori, Katsuaki

    2015-05-01

    The magnetohydrodynamic linear stability with the localized bulk flow oriented parallel to the neutral sheet is investigated, by including the Hall effect and the guide magnetic field. We observe three different unstable modes: a "streaming tearing" mode at a slow flow speed, a "streaming sausage" mode at a medium flow speed, and a "streaming kink" mode at a fast flow speed. The streaming tearing and sausage modes have a standard tearing mode-like structure with symmetric density fluctuations in the neutral sheet, while the kink mode has an asymmetric fluctuation. The growth rate of the streaming tearing mode decreases with increasing magnetic Reynolds number, while the growth rates of the sausage and kink modes do not depend strongly on the Reynolds number. The sausage and kink modes can be unstable for not only super-Alfvénic flow but also sub-Alfvénic flow when the lobe density is low. The wavelengths of these unstable modes are of the same order of magnitude as the thickness of the plasma sheet. Their maximum growth rates are higher than that of a standard tearing mode, and under a strong guide magnetic field, the growth rates of the sausage and kink modes are enhanced, while under a weak guide magnetic field, they are suppressed. For a thin plasma sheet with the Hall effect, the fluctuations of the streaming modes can exist over the plasma sheet. These unstable modes may be regarded as being one of the processes generating Alfvénic turbulence in the plasma sheet during magnetic reconnection.

  17. 1-Ammonio-1-phosphono-pentane-1-phospho-nic acid.

    PubMed

    Bon, V V; Dudko, A V; Kozachkova, A N; Pekhnyo, V I

    2008-11-26

    The title compound, C(5)H(15)NO(6)P(2), was obtained by the reaction of penta-nenitrile with PCl(3) followed by the dropwise addition of water. The asymmetric unit contains one mol-ecule, which exists as a zwitterion with a positive charge on the -NH(3) group and a negative charge on one of the phospho-nic O atoms. The crystal structure displays N-H⋯O and O-H⋯O hydrogen bonding, which creates a three-dimensional network.

  18. Cosmic ray propagation in sub-Alfvénic magnetohydrodynamic turbulence

    NASA Astrophysics Data System (ADS)

    Cohet, R.; Marcowith, A.

    2016-04-01

    Context. The propagation of cosmic rays or energetic charged particles in magnetized turbulence is a complex problem which involves non-linear wave-particle interactions and chaotic magnetic field lines transport. This problem has been addressed until recently using either analytical calculations or simulations using prescribed turbulence models. With the advent of super computers it is now possible to investigate energetic charged particle propagation using direct computation of electromagnetic fields. This is in particular the case for high-energy particles propagation in magnetohydrodynamic turbulence. Aims: This work has the main objective to provide a detailed investigation of cosmic ray propagation in magnetohydrodynamic turbulent fields generated by forcing the fluid velocity field at large scales. It provides a derivation of the particle mean free path dependences in terms of the turbulence level described by the Alfvénic Mach number and in terms of the particle rigidity. Methods: We use an upgrade version of the magnetohydrodynamic code RAMSES which includes a forcing module and a kinetic module and solve the Lorentz equation for each particle. The simulations are performed using a 3 dimension periodical box in the test-particle and magnetostatic limits. The forcing module is implemented using an Ornstein-Uhlenbeck process. An ensemble average over a large number of particle trajectories is applied to reconstruct the particle mean free paths. Results: We derive the cosmic ray mean free paths in terms of the Alfvénic Mach numbers and particle reduced rigidities in different turbulence forcing geometries. The reduced particle rigidity is ρ = rL/L where rL is the particle Larmor radius and L is the simulation box length related to the turbulence coherence or injection scale Linj by L ~ 5 Linj. We have investigated with a special attention compressible and solenoidal forcing geometries. Conclusions: We find that compressible forcing solutions are compatible

  19. Multiscale Nature of the Dissipation Range in Gyrokinetic Simulations of Alfvénic Turbulence.

    PubMed

    Told, D; Jenko, F; TenBarge, J M; Howes, G G; Hammett, G W

    2015-07-10

    Nonlinear energy transfer and dissipation in Alfvén wave turbulence are analyzed in the first gyrokinetic simulation spanning all scales from the tail of the MHD range to the electron gyroradius scale. For typical solar wind parameters at 1 AU, about 30% of the nonlinear energy transfer close to the electron gyroradius scale is mediated by modes in the tail of the MHD cascade. Collisional dissipation occurs across the entire kinetic range k(⊥)ρ(I)≳1. Both mechanisms thus act on multiple coupled scales, which have to be retained for a comprehensive picture of the dissipation range in Alfvénic turbulence. PMID:26207474

  20. Electronic transport properties of ultra-thin Ni and Ni-C nanowires.

    PubMed

    Zhang, Leining; Wu, Weikang; Zhou, Yi; Ren, Hongru; Dong, Jichen; Li, Hui

    2016-02-21

    The structures and electronic transport properties of ultra-thin Ni and Ni-C nanowires obtained from carbon nanotube (CNT) templates are theoretically investigated. C atoms tend to locate at the central positions of nanowires and are surrounded by Ni atoms. Spin polarization at the Fermi level is not responsible for the spin filtration of these nanowires. Increasing C concentration can improve the resistance of nanowires by abating the number of electronic transmission channels and the coupling of electron orbitals between Ni atoms. Moreover, with the increase of diameter, the conductance of these nanowires increases as well. This study is helpful for guiding the synthesis of nanowires with desired applications. PMID:26818090

  1. High-level ab initio predictions for the ionization energy, bond dissociation energies, and heats of formation of nickel carbide (NiC) and its cation (NiC+).

    PubMed

    Lau, Kai-Chung; Chang, Yih Chung; Shi, Xiaoyu; Ng, C Y

    2010-09-21

    The ionization energy (IE) of NiC and the 0 K bond dissociation energies (D(0)) and heats of formation at 0 K (ΔH(o)(f0)) and 298 K (ΔH(o)(f298)) for NiC and NiC(+) are predicted by the wavefunction based CCSDTQ(Full)/CBS approach and the multireference configuration interaction (MRCI) method with Davidson correction (MRCI+Q). The CCSDTQ(Full)/CBS calculations presented here involve the approximation to the complete basis set (CBS) limit at the coupled cluster level up to full quadruple excitations along with the zero-point vibrational energy (ZPVE), high-order correlation, core-valence electronic (CV), spin-orbit coupling (SO), and scalar relativistic effect (SR) corrections. The present calculations provide the correct symmetry predictions for the ground states of NiC and NiC(+) to be (1)∑(+) and (2)∑(+), respectively. The CCSDTQ(Full)/CBS IE(NiC)=8.356 eV is found to compare favorably with the experimental IE value of 8.372 05±0.000 06 eV. The predicted IE(NiC) value at the MRCI+Q/cc-pwCV5Z level, including the ZPVE, SO, and SR effects is 8.00 eV, which is 0.37 eV lower than the experimental value. This work together with the previous experimental and theoretical investigations supports the conclusion that the CCSDTQ(Full)/CBS method is capable of providing reliable IE predictions for 3d-transition metal carbides, such as FeC and NiC. Furthermore, the CCSDTQ(Full)/CBS calculations give the prediction of D(0)(Ni-C)-D(0)(Ni(+)-C)=0.688 eV, which is also consistent with the experimental determination of 0.732 21±0.000 06 eV, whereas the MRCI+Q calculations (with relativistic and CV effects) predict a significantly lower value of 0.39 eV for D(0)(Ni-C)-D(0)(Ni(+)-C). The analysis of the correction terms shows that the CV and valence-valence electronic correlations beyond CCSD(T) wavefunction and the relativistic effect make significant contributions to the calculated thermochemical properties of NiC/NiC(+). For the experimental D(0) and ΔH(o)(f0) values of

  2. Mapping of nursing records into the NIC and the ICNP in a Korean oriental-medicine hospital.

    PubMed

    Lee, Eunjoo; Lee, Mikyoung; Jung, Ok Bun

    2006-01-01

    This study uses mapping methodology to examine the applicability of the Nursing Interventions Classification and the International Classification of Nursing Practice to nursing practice in a Korean Oriental-medicine hospital. Data were collected from the nursing records of 56 stroke patients in one unit, and intervention statements were mapped into NIC and ICNP. Of 147 unique nursing intervention statements extracted, 136 (92.52%) could be mapped into NIC and 99 (67.35%) statements could be completely mapped into ICNP. Using mapping methodology, this study validates that both NIC and ICNP would be useful for documenting nursing care in a Korean hospital, but it also identifies additional concepts that need to be represented in both of these standardized nursing languages. It is recommended that nurses be more careful in documenting their interventions and also that SNLs be developed further to more completely represent nursing practice.

  3. Sunward-propagating Alfvénic Fluctuations Observed in the Heliosphere

    NASA Astrophysics Data System (ADS)

    Li, Hui; Wang, Chi; Belcher, John W.; He, Jiansen; Richardson, John D.

    2016-06-01

    The mixture/interaction of anti-sunward-propagating Alfvénic fluctuations (AFs) and sunward-propagating Alfvénic fluctuations (SAFs) is believed to result in the decrease of the Alfvénicity of solar wind fluctuations with increasing heliocentric distance. However, SAFs are rarely observed at 1 au and solar wind AFs are found to be generally outward. Using the measurements from Voyager 2 and Wind, we perform a statistical survey of SAFs in the heliosphere inside 6 au. We first report two SAF events observed by Voyager 2. One is in the anti-sunward magnetic sector with a strong positive correlation between the fluctuations of magnetic field and solar wind velocity. The other one is in the sunward magnetic sector with a strong negative magnetic field—velocity correlation. Statistically, the percentage of SAFs increases gradually with heliocentric distance, from about 2.7% at 1.0 au to about 8.7% at 5.5 au. These results provide new clues for understanding the generation mechanism of SAFs.

  4. The relaxase of the Rhizobium etli symbiotic plasmid shows nic site cis-acting preference.

    PubMed

    Pérez-Mendoza, Daniel; Lucas, María; Muñoz, Socorro; Herrera-Cervera, José A; Olivares, José; de la Cruz, Fernando; Sanjuán, Juan

    2006-11-01

    Genetic and biochemical characterization of TraA, the relaxase of symbiotic plasmid pRetCFN42d from Rhizobium etli, is described. After purifying the relaxase domain (N265TraA), we demonstrated nic binding and cleavage activity in vitro and thus characterized for the first time the nick site (nic) of a plasmid in the family Rhizobiaceae. We studied the range of N265TraA relaxase specificity in vitro by testing different oligonucleotides in binding and nicking assays. In addition, the ability of pRetCFN42d to mobilize different Rhizobiaceae plasmid origins of transfer (oriT) was examined. Data obtained with these approaches allowed us to establish functional and phylogenetic relationships between different plasmids of this family. Our results suggest novel characteristics of the R. etli pSym relaxase for previously described conjugative systems, with emphasis on the oriT cis-acting preference of this enzyme and its possible biological relevance.

  5. Electronic implementation of national nursing standards--NANDA, NOC and NIC as an effective teaching tool.

    PubMed

    Allred, Sharon K; Smith, Kevin F; Flowers, Laura

    2004-01-01

    With the increased interest in evidence-based medicine, Internet access and the growing emphasis on national standards, there is an increased challenge for teaching institutions and nursing services to teach and implement standards. At the same time, electronic clinical documentation tools have started to become a common format for recording nursing notes. The major aim of this paper is to ascertain and assess the availability of clinical nursing tools based on the NANDA, NOC and NIC standards. Faculty at 20 large nursing schools and directors of nursing at 20 hospitals were interviewed regarding the use of nursing standards in clinical documentation packages, not only for teaching purposes but also for use in hospital-based systems to ensure patient safety. A survey tool was utilized that covered questions regarding what nursing standards are being taught in the nursing schools, what standards are encouraged by the hospitals, and teaching initiatives that include clinical documentation tools. Information was collected on how utilizing these standards in a clinical or hospital setting can improve the overall quality of care. Analysis included univariate and bivariate analysis. The consensus between both groups was that the NANDA, NOC and NIC national standards are the most widely taught and utilized. In addition, a training initiative was identified within a large university where a clinical documentation system based on these standards was developed utilizing handheld devices.

  6. Ion beta dependence on the development of Alfvénic fluctuations in reconnection jets

    NASA Astrophysics Data System (ADS)

    Higashimori, Katsuaki; Hoshino, Masahiro

    2015-03-01

    The generation of magneto-hydro-dynamic (MHD) to ion-scale fluctuations in collisionless magnetic reconnection is discussed using a two-dimensional electromagnetic hybrid code. It is shown that reconnection jets become turbulent specifically in low beta conditions, βi0<0.1-0.2 (where βi0 is the ion plasma beta in initial inflow regions). The fluctuations observed in reconnection jets consist of outgoing Alfvénic fluctuations. As probable candidates for the origin of Alfvénic fluctuations, this study focused on the dynamics in the plasma sheet boundary layer (PSBL) and a current sheet. We suggest that PSBL ion dynamics play an important part in excitation and suppression of waves. PSBL beam ions drive Alfvén waves in MHD to ion scale, kλi<0.5 (λi is ion inertial length), independent of βi0. On the other hand, because the beam temperature is highly correlated with that of inflowing ions, the waves decay by cyclotron damping as the value of the inflow ion beta increases. Local linear analysis suggests that this damping signature changes in βi0˜0.1-0.2 and suppresses the wave activity of Alfvén modes in high beta reconnection jets.

  7. Compressional Alfvénic rogue and solitary waves in magnetohydrodynamic plasmas

    SciTech Connect

    Panwar, Anuraj; Rizvi, H.; Ryu, C. M.

    2013-08-15

    Generation of compressional Alfvénic rogue and solitary waves in magnetohydrodynamic plasmas is investigated. Dispersive effect caused by non-ideal electron inertia currents perpendicular to the ambient magnetic field can balance the nonlinear steepening of waves leading to the formation of a soliton. The reductive perturbation method is used to obtain a Korteweg–de Vries (KdV) equation describing the evolution of the solitary wave. The height of a soliton is proportional to the soliton speed “U” and inversely proportional to plasma “β” (ratio of plasma thermal pressure to pressure of the confining magnetic field) and the width of soliton is proportional to the electron inertial length. KdV equation is used to study the nonlinear evolution of modulationally unstable compressional Alfvénic wavepackets via the nonlinear Schrödinger equation. The characteristics of rogue wave influenced by plasma “β” and the electron inertial length are described.

  8. Reconstruction of a broadband spectrum of Alfvénic fluctuations

    SciTech Connect

    Viñas, Adolfo F; Moya, Pablo S.; Maneva, Yana G.; Araneda, Jaime A.

    2014-05-10

    Alfvénic fluctuations in the solar wind exhibit a high degree of velocities and magnetic field correlations consistent with Alfvén waves propagating away and toward the Sun. Two remarkable properties of these fluctuations are the tendencies to have either positive or negative magnetic helicity (–1 ≤ σ {sub m} ≤ +1) associated with either left- or right- topological handedness of the fluctuations and to have a constant magnetic field magnitude. This paper provides, for the first time, a theoretical framework for reconstructing both the magnetic and velocity field fluctuations with a divergence-free magnetic field, with any specified power spectral index and normalized magnetic- and cross-helicity spectrum field fluctuations for any plasma species. The spectrum is constructed in the Fourier domain by imposing two conditions—a divergence-free magnetic field and the preservation of the sense of magnetic helicity in both spaces—as well as using Parseval's theorem for the conservation of energy between configuration and Fourier spaces. Applications to the one-dimensional spatial Alfvénic propagation are presented. The theoretical construction is in agreement with typical time series and power spectra properties observed in the solar wind. The theoretical ideas presented in this spectral reconstruction provide a foundation for more realistic simulations of plasma waves, solar wind turbulence, and the propagation of energetic particles in such fluctuating fields.

  9. [Development and application of microbiology data monitoring system (Akita-ReNICS) for networking hospitals in Akita Prefecture].

    PubMed

    Takeda, Masahide; Ueki, Shigeharu; Takahashi, Tomoe; Tatsuko, Rumi; Kobayashi, Noriko; Shibata, Hiroyuki; Hirokawa, Makoto

    2013-12-01

    Networking among regional hospitals recently became required for infection control activities in Japan. In Akita prefecture, we developed a microbiology data warehouse for networking hospital laboratories in 2010. Designated users can easily obtain microbiology data and compare it with other participating hospitals using this system. For example, users are able to compare the MRSA/MSSA ratio in Staphylococcus aureus with other participating hospitals in Akita-ReNICS. The effectiveness and assignment of this system were shown by a questionnaire administrated in 2013. In this paper, we clarify the current state and assignment of Akita-ReNICS and consider its effective application for better infection control activities.

  10. Identification and Comparison of Interventions Performed by Korean School Nurses and U.S. School Nurses Using the Nursing Interventions Classification (NIC)

    ERIC Educational Resources Information Center

    Lee, Eunjoo; Park, Hyejin; Nam, Mihwa; Whyte, James

    2011-01-01

    The purpose of the study was to identify Nursing Interventions Classification (NIC) interventions performed by Korean school nurses. The Korean data were then compared to U.S. data from other studies in order to identify differences and similarities between Korean and U.S. school nurse practice. Of the 542 available NIC interventions, 180 were…

  11. Modeling magnetospheric response to synthetic Alfvénic fluctuations in the solar wind: ULF wave fields in the magnetosphere

    NASA Astrophysics Data System (ADS)

    McGregor, S. L.; Hudson, M. K.; Hughes, W. J.

    2014-11-01

    Several observational studies suggest that small fluctuations in the solar wind can drive magnetospheric dynamics, notably ultralow frequency (ULF) waves, especially during high-speed streams (HSS). ULF fluctuations are believed to be a mechanism for controlling and accelerating radiation belt electrons, and are an important aspect to HSS storms. Previous simulation studies have begun to investigate generation of magnetospheric ULF waves by varying upstream solar wind conditions, such as dynamic pressure or velocity shear. Alfvénic fluctuations, however, which are prevalent within the solar wind, have yet to be incorporated into global MHD simulations of the magnetosphere. To investigate the relationship between Alfvénic fluctuations in the solar wind and magnetospheric ULF waves, we present results from the Lyon-Fedder-Mobarry global, three-dimensional magnetohydrodynamic (MHD) code. These simulations are driven with simulated solar wind plasma parameters from the Wang-Sheeley-Arge-Enlil model with and without Alfvén-like fluctuations added. We show that solar wind Alfvénic fluctuations enhance Kelvin-Helmholtz waves along the flanks and drive ULF waves in the dayside magnetosphere. The dayside ULF waves are an enhancement of the compressional component in field-aligned coordinates, due to the varying x component of the velocity (and therefore dynamic pressure) from the Alfvénic fluctuations.

  12. ION KINETIC ENERGY CONSERVATION AND MAGNETIC FIELD STRENGTH CONSTANCY IN MULTI-FLUID SOLAR WIND ALFVÉNIC TURBULENCE

    SciTech Connect

    Matteini, L.; Horbury, T. S.; Schwartz, S. J.; Pantellini, F.; Velli, M.

    2015-03-20

    We investigate the properties of plasma fluid motion in the large-amplitude, low-frequency fluctuations of highly Alfvénic fast solar wind. We show that protons locally conserve total kinetic energy when observed from an effective frame of reference comoving with the fluctuations. For typical properties of the fast wind, this frame can be reasonably identified by alpha particles which, due to their drift with respect to protons at about the Alfvén speed along the magnetic field, do not partake in the fluid low-frequency fluctuations. Using their velocity to transform the proton velocity into the frame of Alfvénic turbulence, we demonstrate that the resulting plasma motion is characterized by a constant absolute value of the velocity, zero electric fields, and aligned velocity and magnetic field vectors as expected for unidirectional Alfvénic fluctuations in equilibrium. We propose that this constraint, via the correlation between velocity and magnetic field in Alfvénic turbulence, is the origin of the observed constancy of the magnetic field; while the constant velocity corresponding to constant energy can only be observed in the frame of the fluctuations, the corresponding constant total magnetic field, invariant for Galilean transformations, remains the observational signature in the spacecraft frame of the constant total energy in the Alfvén turbulence frame.

  13. Alfvénic field-aligned currents, ion upflow and electron precipitation during large geomagnetic storms

    NASA Astrophysics Data System (ADS)

    Hatch, Spencer; LaBelle, James; Chaston, Christopher

    2016-04-01

    We present four years of FAST observations of Alfvénic field-aligned currents (FACs) in the Northern Hemisphere coincident with 40 moderate (Dst < -50 nT) to very large geomagnetic storms. Superposed epoch analysis of Alfvénic activity of storm periods demonstrate a sharp increase in the probability of AlfvÉn wave occurrence just after storm commencement, and analysis based on storm phase shows that the probability of Alfvén wave occurrence increases by more than a factor of 5 on both dayside and nightside. Additionally, recently reported Van Allen Probes measurements in the magnetosphere imply a region (˜60-68 degrees invariant latitude) in the nightside ionosphere where Alfvén waves are statistically likely to be observed during storm main phase; we report statistical observations during main phase showing that this region instead corresponds to both intense electron precipitation (>10 mW m-2) and strong upflowing ion number flux (> 108 cm^{-2 s-1), while observed Alfvénic FAC occurrence rates are diminished relative to Van Allen Probes measurements. FAST observations also indicate that the most intense electron precipitation associated with Alfvénic FACs occurs pre-midnight during storm recovery phase.

  14. Prediction of Alfvénic turbulence near the magnetospheric sash

    NASA Astrophysics Data System (ADS)

    Erickson, G. M.; Siscoe, G. L.; Weimer, D. R.; Siebert, K. D.; Heinemann, M. A.; Sonnerup, B. U. Ö.; Maynard, N. C.; White, W. W.

    2002-04-01

    Results of global MHD simulations are used to examine the susceptibility of magnetosheath plasma to anisotropy-driven instabilities, specifically the mirror mode, electromagnetic ion cyclotron (EMIC), and firehose instabilities. Advection of magnetosheath plasma is followed along MHD-specified streamlines assuming double-adiabatic equations of state, while the anisotropic pressure is constrained by the instability threshold criteria and the condition that the trace of the gyrotropic pressure tensor be three times the MHD specification for the (isotropic) pressure. Following this procedure, mirror mode and EMIC turbulence is indicated in the dayside magnetosheath and in a layer adjacent to the dayside magnetopause, generally in accord with theoretical and observational expectations. The new result is the prediction of strong firehose or Alfvénic turbulence in the magnetosheath adjacent to the magnetospheric sash. Alfvén waves will propagate downwind from the sash. Also, as magnetic field strength increases downwind from the sash, mirror mode and EMIC waves are again indicated.

  15. [CARE NURSE AT REFRACTORY SPIRITUAL SUFFERING USING TAXONOMY NANDA-NOC-NIC].

    PubMed

    Morillo-martín, Mría Socorro; Galán González-Serna, José María; Romero-Serrano, Rocío; Arroyo-Rodríguez, Almudena; Medina, Eulalia Alburquerque

    2015-03-01

    This paper introduces the concept of refractory spiritual suffering in the terminal patient, the factors that influence it, the possibility of their assessment and care approach emphasizing the role of nurse care to despair for identification and relief through the use of taxonomy NANDA-NOC-NIC (NNN). We conclude that it is necessary to incorporate into the care routine screening of spiritual suffering, assessment, prevention and interdisciplinary care. When direct care nursing developed aimed at improving levels of hope that the patient achieves his spiritual suffering terminal decline. In refractory spiritual suffering is necessary to consider the option of palliative sedation in which nurses have a crucial role both in their valuation for the indication and in the administration and evaluation of its therapeutic effects. PMID:26521408

  16. [CARE NURSE AT REFRACTORY SPIRITUAL SUFFERING USING TAXONOMY NANDA-NOC-NIC].

    PubMed

    Morillo-martín, Mría Socorro; Galán González-Serna, José María; Romero-Serrano, Rocío; Arroyo-Rodríguez, Almudena; Medina, Eulalia Alburquerque

    2015-03-01

    This paper introduces the concept of refractory spiritual suffering in the terminal patient, the factors that influence it, the possibility of their assessment and care approach emphasizing the role of nurse care to despair for identification and relief through the use of taxonomy NANDA-NOC-NIC (NNN). We conclude that it is necessary to incorporate into the care routine screening of spiritual suffering, assessment, prevention and interdisciplinary care. When direct care nursing developed aimed at improving levels of hope that the patient achieves his spiritual suffering terminal decline. In refractory spiritual suffering is necessary to consider the option of palliative sedation in which nurses have a crucial role both in their valuation for the indication and in the administration and evaluation of its therapeutic effects.

  17. Super-Alfvénic propagation of substorm reconnection signatures and Poynting flux.

    PubMed

    Shay, M A; Drake, J F; Eastwood, J P; Phan, T D

    2011-08-01

    The propagation of reconnection signatures and their associated energy are examined using kinetic particle-in-cell simulations and Cluster satellite observations. It is found that the quadrupolar out-of-plane magnetic field near the separatrices is associated with a kinetic Alfvén wave. For magnetotail parameters, the parallel propagation of this wave is super-Alfvénic (V(∥) ∼ 1500-5500 km/s) and generates substantial Poynting flux (S ∼ 10(-5)-10(-4) W/m(2)) consistent with Cluster observations of magnetic reconnection. This Poynting flux substantially exceeds that due to frozen-in ion bulk outflows and is sufficient to generate white light aurora in Earth's ionosphere. PMID:21902330

  18. The National Ignition Facility (NIF) and the National Ignition Campaign (NIC)

    SciTech Connect

    Moses, E

    2009-09-17

    The National Ignition Facility (NIF), the world's largest and most powerful laser system for inertial confinement fusion (ICF) and experiments studying high-energy-density (HED) science, is now operational at Lawrence Livermore National Laboratory (LLNL). NIF construction was certified by the Department of Energy as complete on March 27, 2009. NIF, a 192-beam Nd:glass laser facility, will ultimately produce 1.8-MJ, 500-TW of 351-nm third-harmonic, ultraviolet light. On March 10, 2009, total 192-beam energy of 1.1 MJ was demonstrated; this is approximately 30 times more energy than ever produced in an ICF laser system. The principal goal of NIF is to achieve ignition of a deuterium-tritium (DT) fuel capsule and provide access to HED physics regimes needed for experiments related to national security, fusion energy and broader frontier scientific exploration. NIF experiments in support of indirect-drive ignition began in August 2009. These first experiments represent the next phase of the National Ignition Campaign (NIC). The NIC is a national effort to achieve fusion ignition and is coordinated through a detailed execution plan that includes the science, technology, and equipment. Equipment required for ignition experiments includes diagnostics, a cryogenic target manipulator, and user optics. Participants in this effort include LLNL, General Atomics (GA), Los Alamos National Laboratory (LANL), Sandia National Laboratory (SNL), and the University of Rochester Laboratory for Energetics (LLE). The primary goal for NIC is to have all of the equipment operational, integrated into the facility, and ready to begin a credible ignition campaign in 2010. With NIF now operational, the long-sought goal of achieving self-sustained nuclear fusion and energy gain in the laboratory is much closer to realization. Successful demonstration of ignition and net energy gain on NIF will be a major step towards demonstrating the feasibility of Inertial Fusion Energy (IFE) and will likely

  19. Structure function scaling in compressible super-Alfvénic MHD turbulence.

    PubMed

    Padoan, Paolo; Jimenez, Raul; Nordlund, Ake; Boldyrev, Stanislav

    2004-05-14

    Supersonic turbulent flows of magnetized gas are believed to play an important role in the dynamics of star-forming clouds in galaxies. Understanding statistical properties of such flows is crucial for developing a theory of star formation. In this Letter we propose a unified approach for obtaining the velocity scaling in compressible and super-Alfvénic turbulence, valid for the arbitrary sonic Mach number, M(S). We demonstrate with numerical simulations that the scaling can be described with the She-Lévêque formalism, where only one parameter, interpreted as the Hausdorff dimension of the most intense dissipative structures, needs to be varied as a function of M(S). Our results thus provide a method for obtaining the velocity scaling in interstellar clouds once their Mach numbers have been inferred from observations.

  20. POTENTIAL EVIDENCE FOR THE ONSET OF ALFVÉNIC TURBULENCE IN TRANS-EQUATORIAL CORONAL LOOPS

    SciTech Connect

    De Moortel, I.; Threlfall, J.; McIntosh, S. W.; Bethge, C.; Liu, J. E-mail: mscott@ucar.edu

    2014-02-20

    This study investigates Coronal Multi-channel Polarimeter Doppler-shift observations of a large, off-limb, trans-equatorial loop system observed on 2012 April 10-11. Doppler-shift oscillations with a broad range of frequencies are found to propagate along the loop with a speed of about 500 km s{sup –1}. The power spectrum of perturbations travelling up from both loop footpoints is remarkably symmetric, probably due to the almost perfect north-south alignment of the loop system. Compared to the power spectrum at the footpoints of the loop, the Fourier power at the apex appears to be higher in the high-frequency part of the spectrum than expected from theoretical models. We suggest this excess high-frequency power could be tentative evidence for the onset of a cascade of the low-to-mid frequency waves into (Alfvénic) turbulence.

  1. Susceptibility testing: accurate and reproducible minimum inhibitory concentration (MIC) and non-inhibitory concentration (NIC) values.

    PubMed

    Lambert, R J; Pearson, J

    2000-05-01

    Measuring the minimum inhibitory concentration (MIC) of a substance by current methods is straightforward, whereas obtaining useful comparative information from the tests can be more difficult. A simple technique and a method of data analysis are reported which give the experimentalist more useful information from susceptibility testing. This method makes use of a 100-well microtitre plate and the analysis uses all the growth information, obtained by turbidometry, from each and every well of the microtitre plate. A modified Gompertz function is used to fit the data, from which a more exact value can be obtained for the MIC. The technique also showed that at certain concentrations of inhibitor, there was no effect on growth relative to a control well (zero inhibitor). Above a threshold value, which has been termed the non-inhibitory concentration or NIC, growth becomes limiting until it reaches the MIC, where no growth relative to the control is observed.

  2. Measuring the Alfvénic nature of the interstellar medium: Velocity anisotropy revisited

    SciTech Connect

    Burkhart, Blakesley; Lazarian, A.; Leão, I. C.; De Medeiros, J. R.; Esquivel, A.

    2014-08-01

    The dynamics of the interstellar medium (ISM) are strongly affected by turbulence, which shows increased anisotropy in the presence of a magnetic field. We expand upon the Esquivel and Lazarian method to estimate the Alfvén Mach number using the structure function anisotropy in velocity centroid data from Position-Position-Velocity maps. We utilize three-dimensional magnetohydrodynamic simulations of fully developed turbulence, with a large range of sonic and Alfvénic Mach numbers, to produce synthetic observations of velocity centroids with observational characteristics such as thermal broadening, cloud boundaries, noise, and radiative transfer effects of carbon monoxide. In addition, we investigate how the resulting anisotropy-Alfvén Mach number dependency found in Esquivel and Lazarian might change when taking the second moment of the Position-Position-Velocity cube or when using different expressions to calculate the velocity centroids. We find that the degree of anisotropy is related primarily to the magnetic field strength (i.e., Alfvén Mach number) and the line-of-sight orientation, with a secondary effect on sonic Mach number. If the line of sight is parallel to up to ≈45 deg off of the mean field direction, the velocity centroid anisotropy is not prominent enough to distinguish different Alfvénic regimes. The observed anisotropy is not strongly affected by including radiative transfer, although future studies should include additional tests for opacity effects. These results open up the possibility of studying the magnetic nature of the ISM using statistical methods in addition to existing observational techniques.

  3. LLNL Contribution to LLE FY09 Annual Report: NIC and HED Results

    SciTech Connect

    Heeter, R F; Landen, O L; Hsing, W W; Fournier, K B

    2009-10-01

    In FY09, LLNL led 238 target shots on the OMEGA Laser System. Approximately half of these LLNL-led shots supported the National Ignition Campaign (NIC). The remainder was dedicated to experiments for the high-energy-density stewardship experiments (HEDSE). Objectives of the LLNL led NIC campaigns at OMEGA included: (1) Laser-plasma interaction studies in physical conditions relevant for the NIF ignition targets; (2) Demonstration of Tr = 100 eV foot symmetry tuning using a reemission sphere; (3) X-ray scattering in support of conductivity measurements of solid density Be plasmas; (4) Experiments to study the physical properties (thermal conductivity) of shocked fusion fuels; (5) High-resolution measurements of velocity nonuniformities created by microscopic perturbations in NIF ablator materials; (6) Development of a novel Compton Radiography diagnostic platform for ICF experiments; and (7) Precision validation of the equation of state for quartz. The LLNL HEDSE campaigns included the following experiments: (1) Quasi-isentropic (ICE) drive used to study material properties such as strength, equation of state, phase, and phase-transition kinetics under high pressure; (2) Development of a high-energy backlighter for radiography in support of material strength experiments using Omega EP and the joint OMEGA-OMEGA-EP configuration; (3) Debris characterization from long-duration, point-apertured, point-projection x-ray backlighters for NIF radiation transport experiments; (4) Demonstration of ultrafast temperature and density measurements with x-ray Thomson scattering from short-pulse laser-heated matter; (5) The development of an experimental platform to study nonlocal thermodynamic equilibrium (NLTE) physics using direct-drive implosions; (6) Opacity studies of high-temperature plasmas under LTE conditions; and (7) Characterization of copper (Cu) foams for HEDSE experiments.

  4. Two-dimensional hybrid simulations of Alfvénic fluctuations in the expanding solar wind

    NASA Astrophysics Data System (ADS)

    Landi, Simone; Matteini, Lorenzo; Hellinger, Petr; Verdini, Andrea; Travnicek, Pavel M.; Burgess, David

    2014-05-01

    The supersonic expansion of the solar wind and wave particle interactions which characterize the ion evolution are investigated using a hybrid expanding box model. We present 2D simulations of the interaction between Alfvénic like fluctuations using two different geometries: an in-plane mean magnetic field and an out-of-plane mean magnetic field. The initial conditions for the Alfvénic spectrum are a) a mixed parallel and oblique propagating modes (in-plane) and b) purely perpendicular wavevectors (out-of-plane). For both geometries we consider 2 kinds of initial conditions. 1) the imbalanced case with Alfvén waves propagating in one direction along the guide field, that is an initial condition with maximal correlation between u and b (maximal cross helicity and null residual energy) 2) the balanced case with counter-propagating Alfvén waves and with an initial magnetic energy dominating over kinetic energy (null cross helicity and maximal residual energy). Such characteristics are the most frequently observed in the solar wind. We investigate parallel and perpendicular proton heating properties of the turbulent spectra in the simulations and the influence of the expansion on the evolution of turbulence and its decay. As suggested by solar wind observations, the perpendicular heating and parallel cooling is not strong enough to overcome the expansion-driven anisotropic cooling. Once the expansion drives the system unstable with respect to the fire-hose instability driven by the proton temperature anisotropy, electromagnetic fluctuations are generated. These waves scatter protons and reduce their temperature anisotropy. Consequently, this mechanism constrains the temperature anisotropy and the system evolves along a marginal instability path.

  5. Developing a model for the mercury cycle in the Marano-Grado Lagoon (Italy)

    EPA Science Inventory

    The Marano-Grado Lagoon is a wetland system of about 160 km2 located in the Northern Adriatic Sea (Italy) between the Tagliamento and the Isonzo River mouths. The lagoon morphology and biogeochemistry are primarily controlled by the exchange with the Adriatic Sea and, to a lesser...

  6. Low-density anomalies and sub-Alfvénic solar wind

    NASA Astrophysics Data System (ADS)

    Usmanov, A. V.; Goldstein, M. L.; Ogilvie, K. W.; Farrell, W. M.; Lawrence, G. R.

    2005-01-01

    During 10-12 May 1999, the solar wind density dropped to an anomalously low value of ˜0.1 cm-3. The density depletion occurred in the midst of relatively slow wind flow, in between faster flows, and was apparently associated with neither a coronal mass ejection nor a fast corotating stream. While the magnetic field intensity did not show any notable variation across the density depletion, plasma analyzers on the ACE and Wind spacecraft revealed an abnormally strong nonradial flow component with an azimuthal speed that peaked at ˜100 km s-1. [2000b] suggested that the density anomaly was, in fact, a rarefaction at the trailing edge of relatively fast flow that formed as a result of suppression of coronal outflow from a region that earlier provided fast wind flow. The suppression in turn may have resulted from a rapid restructuring of solar magnetic fields during the polar field reversal. Here we show results from a two-dimensional time-dependent MHD simulation applied to the helioequatorial plane. The initially longitude-independent Parker solar wind and Archimedean spiral magnetic field are disturbed by a low-velocity/high-density jump on an inner computational boundary at 20 R⊙. We follow the development and propagation of the rarefaction to Earth orbit and compare pseudo-time series with near-Earth spacecraft measurements. We show that a strong rarefaction can develop behind the fast flow and that simulation results and spacecraft observations are generally in agreement. The simulated radial magnetic field shows a relatively small variation across the density anomaly compared with that of the density. The stream interaction generates strong azimuthal velocities in the slow flow region, as observed. The simulation shows a sub-Alfvénic flow region embedded within the low-density region that does not extend all the way back to the Sun but which has become disconnected as the depletion propagates to Earth orbit. We discuss also the correlation between low

  7. Alfvénic wave packets collision in a kinetic plasma

    NASA Astrophysics Data System (ADS)

    Pezzi, Oreste; Parashar, Tulasi N.; Servidio, Sergio; Valentini, Francesco; Malara, Francesco; Matthaeus, William H.; Veltri, Pierluigi

    2016-04-01

    The problem of two colliding and counter-propagating Alfvénic wave packets has been investigated in detail since the late Seventies. In particular Moffatt [1] and Parker [2] showed that, in the framework of the incompressible magnetohydrodynamics (MHD), nonlinear interactions can develop only during the overlapping of the two packets. Here we describe a similar problem in the framework of the kinetic physics. The collision of two quasi-Alfvénic packets has been analyzed by means of MHD, Hall-MHD and kinetic simulations performed with two different hybrid codes: a PIC code [3] and a Vlasov-Maxwell code [4]. Due to the huge computational cost, only a 2D-3V phase space is allowed (two dimensions in the physical space, three dimensions in the velocity space). Preliminary results suggest that, as well as in the MHD case, the most relevant nonlinear effects occur during the overlapping of the two packets. For both the PIC and Vlasov cases, strong temperature anisotropies are present during the evolution of the wave packets. Moreover, due to the absence of numerical noise, Vlasov simulations show that the collision of the counter-propagating solitary waves produces a significant beam in the velocity distribution functions [5], which, instead, cannot be appreciated in PIC simulations. We remark that, beyond the interest of studying a well-known MHD problem in the realm of the kinetic physics, our results allows also to compare different numerical codes. [1] H.K. Moffatt, Field generation in electrically conducting fluids (Cambridge University Press, 1978). [2] E.N. Parker, Cosmical magnetic fields: their origin and their activity (Oxford University Press, 1979). [3] T.N. Parashar, M.A. Shay, P.A. Cassak and W.H. Matthaeus, Physics of Plasmas 16, 032310 (2009). [4] F. Valentini, P. Trávníček, F. Califano, P. Hellinger & A. Mangeney, Journal of Computational Physics 225, 753-770 (2007). [5] J. He, C. Tu, E. Marsch, C.H. Chen, L. Wang, Z. Pei, L. Zhang, C.S. Salem and S

  8. Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.

    PubMed

    Jiménez, José I; Canales, Angeles; Jiménez-Barbero, Jesús; Ginalski, Krzysztof; Rychlewski, Leszek; García, José L; Díaz, Eduardo

    2008-08-12

    The aerobic catabolism of nicotinic acid (NA) is considered a model system for degradation of N-heterocyclic aromatic compounds, some of which are major environmental pollutants; however, the complete set of genes as well as the structural-functional relationships of most of the enzymes involved in this process are still unknown. We have characterized a gene cluster (nic genes) from Pseudomonas putida KT2440 responsible for the aerobic NA degradation in this bacterium and when expressed in heterologous hosts. The biochemistry of the NA degradation through the formation of 2,5-dihydroxypyridine and maleamic acid has been revisited, and some gene products become the prototype of new types of enzymes with unprecedented molecular architectures. Thus, the initial hydroxylation of NA is catalyzed by a two-component hydroxylase (NicAB) that constitutes the first member of the xanthine dehydrogenase family whose electron transport chain to molecular oxygen includes a cytochrome c domain. The Fe(2+)-dependent dioxygenase (NicX) converts 2,5-dihydroxypyridine into N-formylmaleamic acid, and it becomes the founding member of a new family of extradiol ring-cleavage dioxygenases. Further conversion of N-formylmaleamic acid to formic and maleamic acid is catalyzed by the NicD protein, the only deformylase described so far whose catalytic triad is similar to that of some members of the alpha/beta-hydrolase fold superfamily. This work allows exploration of the existence of orthologous gene clusters in saprophytic bacteria and some pathogens, where they might stimulate studies on their role in virulence, and it provides a framework to develop new biotechnological processes for detoxification/biotransformation of N-heterocyclic aromatic compounds.

  9. Alfvénic fluctuations in the solar wind and the orientation of the underlying heliospheric magnetic field

    NASA Astrophysics Data System (ADS)

    Gosling, J. T.; Teh, W.

    2009-12-01

    In their purest form, Alfvénic fluctuations in the solar wind are transverse fluctuations displaying coupled variations in velocity, V, and magnetic field, B, in which |B| remains nearly constant. Consequently, the fluctuations in the component of V and B corresponding to the direction of the underlying magnetic field vector, Bo, upon which the fluctuations are superimposed are always one-sided relative to base values rather than being equitably distributed about average values. Average values of the direction of B in the presence of large-amplitude Alfvénic fluctuations in the solar wind thus generally do not correspond to the direction of Bo, the quantity needed for comparisons with global models of the heliospheric magnetic field and for determining the parallel and perpendicular components of the fluctuation k-vectors. Here we illustrate the one-sided aspect of the fluctuations in Helios 1 data obtained at 0.36 AU at a time when Bo was directed nearly radially outward from the Sun. Using the Helios data and simulated data sets containing large amplitude Alfvénic fluctuations in which the direction of Bo is known precisely we demonstrate that the orientation of the average magnetic field vector, Bav, does not, in general, correspond to the direction of Bo. Minimum variance analysis of our simulated sets of Alfvénic fluctuations in the solar wind demonstrates that the minimum variance direction corresponds roughly to the direction of Bav, consistent with many previous observational studies, but does not correspond to the direction of propagation of the fluctuations, the group velocity of which is directed along Bo.

  10. Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule and the National Instant Criminal Background Check System (NICS). Final rule.

    PubMed

    2016-01-01

    The Department of Health and Human Services (HHS or "the Department'') is issuing this final rule to modify the Health Insurance Portability and Accountability Act of 1996 (HIPAA) Privacy Rule to expressly permit certain HIPAA covered entities to disclose to the National Instant Criminal Background Check System (NICS) the identities of individuals who are subject to a Federal "mental health prohibitor'' that disqualifies them from shipping, transporting, possessing, or receiving a firearm. The NICS is a national system maintained by the Federal Bureau of Investigation (FBI) to conduct background checks on persons who may be disqualified from receiving firearms based on Federally prohibited categories or State law. Among the persons subject to the Federal mental health prohibitor established under the Gun Control Act of 1968 and implementing regulations issued by the Department of Justice (DOJ) are individuals who have been involuntarily committed to a mental institution; found incompetent to stand trial or not guilty by reason of insanity; or otherwise have been determined by a court, board, commission, or other lawful authority to be a danger to themselves or others or to lack the mental capacity to contract or manage their own affairs, as a result of marked subnormal intelligence or mental illness, incompetency, condition, or disease. Under this final rule, only covered entities with lawful authority to make the adjudications or commitment decisions that make individuals subject to the Federal mental health prohibitor, or that serve as repositories of information for NICS reporting purposes, are permitted to disclose the information needed for these purposes. The disclosure is restricted to limited demographic and certain other information needed for NICS purposes. The rule specifically prohibits the disclosure of diagnostic or clinical information, from medical records or other sources, and any mental health information beyond the indication that the individual

  11. Health Insurance Portability and Accountability Act (HIPAA) Privacy Rule and the National Instant Criminal Background Check System (NICS). Final rule.

    PubMed

    2016-01-01

    The Department of Health and Human Services (HHS or "the Department'') is issuing this final rule to modify the Health Insurance Portability and Accountability Act of 1996 (HIPAA) Privacy Rule to expressly permit certain HIPAA covered entities to disclose to the National Instant Criminal Background Check System (NICS) the identities of individuals who are subject to a Federal "mental health prohibitor'' that disqualifies them from shipping, transporting, possessing, or receiving a firearm. The NICS is a national system maintained by the Federal Bureau of Investigation (FBI) to conduct background checks on persons who may be disqualified from receiving firearms based on Federally prohibited categories or State law. Among the persons subject to the Federal mental health prohibitor established under the Gun Control Act of 1968 and implementing regulations issued by the Department of Justice (DOJ) are individuals who have been involuntarily committed to a mental institution; found incompetent to stand trial or not guilty by reason of insanity; or otherwise have been determined by a court, board, commission, or other lawful authority to be a danger to themselves or others or to lack the mental capacity to contract or manage their own affairs, as a result of marked subnormal intelligence or mental illness, incompetency, condition, or disease. Under this final rule, only covered entities with lawful authority to make the adjudications or commitment decisions that make individuals subject to the Federal mental health prohibitor, or that serve as repositories of information for NICS reporting purposes, are permitted to disclose the information needed for these purposes. The disclosure is restricted to limited demographic and certain other information needed for NICS purposes. The rule specifically prohibits the disclosure of diagnostic or clinical information, from medical records or other sources, and any mental health information beyond the indication that the individual

  12. High-latitude magnetic reconnection in sub-Alfvénic flow: Interball tail observations on May 29, 1996

    NASA Astrophysics Data System (ADS)

    Avanov, L. A.; Fuselier, S. A.; Vaisberg, O. L.

    2001-12-01

    The Interball Tail spacecraft crossed the high-latitude magnetopause near the cusp region under northward interplanetary magnetic field (IMF) conditions on May 29, 1996, with magnetic local time and magnetic latitude of ~7.3 hours and ~65.4°, respectively. Under these IMF conditions the Interball Tail spacecraft observed quasi-steady reconnection in progress and evidence for a relatively stable reconnection site at high latitudes. Sunward plasma flow observed by Interball Tail and a determination of the tangential stress balance indicated that reconnection was occurring poleward of the Earth's magnetic cusp, above the space-craft's location. At these high latitudes the gasdynamic model of the solar wind/magnetosphere interaction indicates that the magnetosheath flow should be super-Alfvénic, and therefore that the reconnection site should have propagated tailward. However, the spacecraft observed sub-Alfvénic flow in the magnetosheath region adjacent to the magnetopause current layer near the reconnection site indicating that the reconnection site may have moved in the sunward direction. These observations suggest that the region of sub-Alfvénic flow and stable, quasi-steady reconnection extend to very high latitudes under northward IMF conditions. It is shown that the thickness of the magnetopause current layer for this event (estimated as ~1600 km) is consistent with that found for reconnection at the dayside magnetopause.

  13. Alfvénic waves with sufficient energy to power the quiet solar corona and fast solar wind.

    PubMed

    McIntosh, Scott W; De Pontieu, Bart; Carlsson, Mats; Hansteen, Viggo; Boerner, Paul; Goossens, Marcel

    2011-07-28

    Energy is required to heat the outer solar atmosphere to millions of degrees (refs 1, 2) and to accelerate the solar wind to hundreds of kilometres per second (refs 2-6). Alfvén waves (travelling oscillations of ions and magnetic field) have been invoked as a possible mechanism to transport magneto-convective energy upwards along the Sun's magnetic field lines into the corona. Previous observations of Alfvénic waves in the corona revealed amplitudes far too small (0.5 km s(-1)) to supply the energy flux (100-200 W m(-2)) required to drive the fast solar wind or balance the radiative losses of the quiet corona. Here we report observations of the transition region (between the chromosphere and the corona) and of the corona that reveal how Alfvénic motions permeate the dynamic and finely structured outer solar atmosphere. The ubiquitous outward-propagating Alfvénic motions observed have amplitudes of the order of 20 km s(-1) and periods of the order of 100-500 s throughout the quiescent atmosphere (compatible with recent investigations), and are energetic enough to accelerate the fast solar wind and heat the quiet corona. PMID:21796206

  14. Alfvénic waves with sufficient energy to power the quiet solar corona and fast solar wind.

    PubMed

    McIntosh, Scott W; De Pontieu, Bart; Carlsson, Mats; Hansteen, Viggo; Boerner, Paul; Goossens, Marcel

    2011-07-27

    Energy is required to heat the outer solar atmosphere to millions of degrees (refs 1, 2) and to accelerate the solar wind to hundreds of kilometres per second (refs 2-6). Alfvén waves (travelling oscillations of ions and magnetic field) have been invoked as a possible mechanism to transport magneto-convective energy upwards along the Sun's magnetic field lines into the corona. Previous observations of Alfvénic waves in the corona revealed amplitudes far too small (0.5 km s(-1)) to supply the energy flux (100-200 W m(-2)) required to drive the fast solar wind or balance the radiative losses of the quiet corona. Here we report observations of the transition region (between the chromosphere and the corona) and of the corona that reveal how Alfvénic motions permeate the dynamic and finely structured outer solar atmosphere. The ubiquitous outward-propagating Alfvénic motions observed have amplitudes of the order of 20 km s(-1) and periods of the order of 100-500 s throughout the quiescent atmosphere (compatible with recent investigations), and are energetic enough to accelerate the fast solar wind and heat the quiet corona.

  15. A threonine stabilizes the NiC and NiR catalytic intermediates of [NiFe]-hydrogenase.

    PubMed

    Abou-Hamdan, Abbas; Ceccaldi, Pierre; Lebrette, Hugo; Gutiérrez-Sanz, Oscar; Richaud, Pierre; Cournac, Laurent; Guigliarelli, Bruno; De Lacey, Antonio L; Léger, Christophe; Volbeda, Anne; Burlat, Bénédicte; Dementin, Sébastien

    2015-03-27

    The heterodimeric [NiFe] hydrogenase from Desulfovibrio fructosovorans catalyzes the reversible oxidation of H2 into protons and electrons. The catalytic intermediates have been attributed to forms of the active site (NiSI, NiR, and NiC) detected using spectroscopic methods under potentiometric but non-catalytic conditions. Here, we produced variants by replacing the conserved Thr-18 residue in the small subunit with Ser, Val, Gln, Gly, or Asp, and we analyzed the effects of these mutations on the kinetic (H2 oxidation, H2 production, and H/D exchange), spectroscopic (IR, EPR), and structural properties of the enzyme. The mutations disrupt the H-bond network in the crystals and have a strong effect on H2 oxidation and H2 production turnover rates. However, the absence of correlation between activity and rate of H/D exchange in the series of variants suggests that the alcoholic group of Thr-18 is not necessarily a proton relay. Instead, the correlation between H2 oxidation and production activity and the detection of the NiC species in reduced samples confirms that NiC is a catalytic intermediate and suggests that Thr-18 is important to stabilize the local protein structure of the active site ensuring fast NiSI-NiC-NiR interconversions during H2 oxidation/production.

  16. Characterization of the Alfvénic slow solar wind: from turbulent spectra to particle distribution functions

    NASA Astrophysics Data System (ADS)

    D'Amicis, Raffaella; Matteini, Lorenzo; Bruno, Roberto

    2016-04-01

    The solar wind is a turbulent medium in which the energy cascade process is widely considered to result from the nonlinear interaction between the inward and outward propagating Alfvén waves. Fast and slow wind show a different behavior supporting the idea of an older turbulence in the slow wind and an Alfvénic younger turbulence in the fast wind. However, our study suggests that even slow wind can be sometimes highly Alfvénic and this has implications on the spectral features as well. Two kinds of slow solar wind can then be distinguished, characterized by different large-scale properties but also by different micro-scale phenomena. These findings all support a different solar origin of these two kinds of slow wind, a topic long debated in the past years for the typical slow wind. It has been found that the Alfvénic slow wind does not originate from active regions or the cusp of the helmet streamers as the typical slow wind rather from the boundary between streamers and coronal holes. This would determine the similarities with the fast solar wind suggesting a major role played by the super-radial expansion responsible for the lower velocity. We also discuss relevant implications of these new findings for the upcoming Solar Orbiter and Solar Probe Plus missions, and for turbulence measurements close to the Sun.

  17. [Development of a microbiology data warehouse (Akita-ReNICS) for networking hospitals in a medical region].

    PubMed

    Ueki, Shigeharu; Kayaba, Hiroyuki; Tomita, Noriko; Kobayashi, Noriko; Takahashi, Tomoe; Obara, Toshikage; Takeda, Masahide; Moritoki, Yuki; Itoga, Masamichi; Ito, Wataru; Ohsaga, Atsushi; Kondoh, Katsuyuki; Chihara, Junichi

    2011-04-01

    The active involvement of hospital laboratory in surveillance is crucial to the success of nosocomial infection control. The recent dramatic increase of antimicrobial-resistant organisms and their spread into the community suggest that the infection control strategy of independent medical institutions is insufficient. To share the clinical data and surveillance in our local medical region, we developed a microbiology data warehouse for networking hospital laboratories in Akita prefecture. This system, named Akita-ReNICS, is an easy-to-use information management system designed to compare, track, and report the occurrence of antimicrobial-resistant organisms. Participating laboratories routinely transfer their coded and formatted microbiology data to ReNICS server located at Akita University Hospital from their health care system's clinical computer applications over the internet. We established the system to automate the statistical processes, so that the participants can access the server to monitor graphical data in the manner they prefer, using their own computer's browser. Furthermore, our system also provides the documents server, microbiology and antimicrobiotic database, and space for long-term storage of microbiological samples. Akita-ReNICS could be a next generation network for quality improvement of infection control.

  18. A Threonine Stabilizes the NiC and NiR Catalytic Intermediates of [NiFe]-hydrogenase*

    PubMed Central

    Abou-Hamdan, Abbas; Ceccaldi, Pierre; Lebrette, Hugo; Gutiérrez-Sanz, Oscar; Richaud, Pierre; Cournac, Laurent; Guigliarelli, Bruno; De Lacey, Antonio L.; Léger, Christophe; Volbeda, Anne; Burlat, Bénédicte; Dementin, Sébastien

    2015-01-01

    The heterodimeric [NiFe] hydrogenase from Desulfovibrio fructosovorans catalyzes the reversible oxidation of H2 into protons and electrons. The catalytic intermediates have been attributed to forms of the active site (NiSI, NiR, and NiC) detected using spectroscopic methods under potentiometric but non-catalytic conditions. Here, we produced variants by replacing the conserved Thr-18 residue in the small subunit with Ser, Val, Gln, Gly, or Asp, and we analyzed the effects of these mutations on the kinetic (H2 oxidation, H2 production, and H/D exchange), spectroscopic (IR, EPR), and structural properties of the enzyme. The mutations disrupt the H-bond network in the crystals and have a strong effect on H2 oxidation and H2 production turnover rates. However, the absence of correlation between activity and rate of H/D exchange in the series of variants suggests that the alcoholic group of Thr-18 is not necessarily a proton relay. Instead, the correlation between H2 oxidation and production activity and the detection of the NiC species in reduced samples confirms that NiC is a catalytic intermediate and suggests that Thr-18 is important to stabilize the local protein structure of the active site ensuring fast NiSI-NiC-NiR interconversions during H2 oxidation/production. PMID:25666617

  19. Relaxase DNA binding and cleavage are two distinguishable steps in conjugative DNA processing that involve different sequence elements of the nic site.

    PubMed

    Lucas, María; González-Pérez, Blanca; Cabezas, Matilde; Moncalian, Gabriel; Rivas, Germán; de la Cruz, Fernando

    2010-03-19

    TrwC, the relaxase of plasmid R388, catalyzes a series of concerted DNA cleavage and strand transfer reactions on a specific site (nic) of its origin of transfer (oriT). nic contains the cleavage site and an adjacent inverted repeat (IR(2)). Mutation analysis in the nic region indicated that recognition of the IR(2) proximal arm and the nucleotides located between IR(2) and the cleavage site were essential for supercoiled DNA processing, as judged either by in vitro nic cleavage or by mobilization of a plasmid containing oriT. Formation of the IR(2) cruciform and recognition of the distal IR(2) arm and loop were not necessary for these reactions to take place. On the other hand, IR(2) was not involved in TrwC single-stranded DNA processing in vitro. For single-stranded DNA nic cleavage, TrwC recognized a sequence embracing six nucleotides upstream of the cleavage site and two nucleotides downstream. This suggests that TrwC DNA binding and cleavage are two distinguishable steps in conjugative DNA processing and that different sequence elements are recognized by TrwC in each step. IR(2)-proximal arm recognition was crucial for the initial supercoiled DNA binding. Subsequent recognition of the adjacent single-stranded DNA binding site was required to position the cleavage site in the active center of the protein so that the nic cleavage reaction could take place.

  20. Electronic fine structure in the nickel carbide superconductor Th2NiC2

    NASA Astrophysics Data System (ADS)

    Quan, Y.; Pickett, W. E.

    2013-07-01

    The recently reported nickel carbide superconductor body centered tetragonal I4/mmm Th2NiC2 with Tc=8.5 K increasing to 11.2 K upon alloying Th with Sc is found to have very fine structure in its electronic spectrum, according to density functional based first-principles calculations. The filled Ni 3d band complex is hybridized with C 2p and Th character to and through the Fermi level (EF), and a sharply structured density of states arises only when spin-orbit coupling is included, which splits a zone-center degeneracy, leaving a very flat band edge lying at the Fermi level. The flat part of the band corresponds to an effective mass mz*→∞ with large and negative mx*=my*. Although the region over which the effective mass characterization applies is less than 1% of the zone volume, it supplies on the order of half the states at (or just above) the Fermi level. The observed increase of Tc by hole doping is accounted for if the reference as-synthesized sample is minutely hole doped, which decreases the Fermi level density of states and will provide some stabilization. In this scenario, electron doping will increase the Fermi level density of states and the superconducting critical temperature. Vibrational properties are presented, and enough coupling to the C-Ni-C stretch mode at 70 meV is obtained to imply that superconductivity is electron-phonon mediated.

  1. Upper-hybrid wave-driven Alfvénic turbulence in magnetized dusty plasmas.

    PubMed

    Misra, A P; Banerjee, S

    2011-03-01

    The nonlinear dynamics of coupled electrostatic upper-hybrid (UH) and Alfvén waves (AWs) is revisited in a magnetized electron-ion plasma with charged dust impurities. A pair of nonlinear equations that describe the interaction of UH wave envelopes (including the relativistic electron mass increase) and the density as well as the compressional magnetic field perturbations associated with the AWs are solved numerically to show that many coherent solitary patterns can be excited and saturated due to modulational instability of unstable UH waves. The evolution of these solitary patterns is also shown to appear in the states of spatiotemporal coherence, temporal as well as spatiotemporal chaos, due to collision and fusion among the patterns in stochastic motion. Furthermore, these spatiotemporal features are demonstrated by the analysis of wavelet power spectra. It is found that a redistribution of wave energy takes place to higher harmonic modes with small wavelengths, which, in turn, results in the onset of Alfvénic turbulence in dusty magnetoplasmas. Such a scenario can occur in the vicinity of Saturn's magnetosphere as many electrostatic solitary structures have been observed there by the Cassini spacecraft. PMID:21517632

  2. Plasma Heating Inside Interplanetary Coronal Mass Ejections by Alfvénic Fluctuations Dissipation

    NASA Astrophysics Data System (ADS)

    Li, Hui; Wang, Chi; He, Jiansen; Zhang, Lingqian; Richardson, John D.; Belcher, John W.; Tu, Cui

    2016-11-01

    Nonlinear cascade of low-frequency Alfvénic fluctuations (AFs) is regarded as one of the candidate energy sources that heat plasma during the non-adiabatic expansion of interplanetary coronal mass ejections (ICMEs). However, AFs inside ICMEs were seldom reported in the literature. In this study, we investigate AFs inside ICMEs using observations from Voyager 2 between 1 and 6 au. It has been found that AFs with a high degree of Alfvénicity frequently occurred inside ICMEs for almost all of the identified ICMEs (30 out of 33 ICMEs) and for 12.6% of the ICME time interval. As ICMEs expand and move outward, the percentage of AF duration decays linearly in general. The occurrence rate of AFs inside ICMEs is much less than that in ambient solar wind, especially within 4.75 au. AFs inside ICMEs are more frequently presented in the center and at the boundaries of ICMEs. In addition, the proton temperature inside ICME has a similar “W”-shaped distribution. These findings suggest significant contribution of AFs on local plasma heating inside ICMEs.

  3. Microstructure evolution with varied layer thickness in magnetron-sputtered Ni/C multilayer films

    PubMed Central

    Peng, Jichang; Li, Wenbin; Huang, Qiushi; Wang, Zhanshan

    2016-01-01

    The microstructure evolution of magnetron-sputtered Ni/C multilayers was investigated by varying the Ni and C layer thickness in the region of a few nanometers. For the samples having 2.6-nm-thick C layers, the interface width increases from 0.37 to 0.81 nm as the Ni layer thickness decreases from 4.3 to 1.3 nm. Especially for the samples with Ni layers less than 2.0 nm, the interface width changes significantly due to the discontinuously distributed Ni crystallites. For the samples having 2.8-nm-thick Ni layers, the interface width increases from 0.37 to 0.59 nm when the C layer thickness decreases from 4.3 to 0.7 nm. The evolution of interface microstructures with varied Ni and C layers is explained based on a proposed simple growth model of Ni and C layers. PMID:27515586

  4. Multiple charge density wave transitions in the antiferromagnets R NiC2 (R =Gd ,Tb)

    NASA Astrophysics Data System (ADS)

    Shimomura, S.; Hayashi, C.; Hanasaki, N.; Ohnuma, K.; Kobayashi, Y.; Nakao, H.; Mizumaki, M.; Onodera, H.

    2016-04-01

    X-ray scattering and electrical resistivity measurements were performed on GdNiC2 and TbNiC2. We found a set of satellite peaks characterized by q1=(0.5 ,η ,0 ) below T1, at which the resistivity shows a sharp inflection, suggesting the charge density wave (CDW) formation. The value of η decreases with decreasing temperature below T1, and then a transition to a commensurate phase with q1 C=(0.5 ,0.5 ,0 ) takes place. The diffuse scattering observed above T1 indicates the presence of soft phonon modes associated with CDW instabilities at q1 and q2=(0.5 ,0.5 ,0.5 ) . The long-range order given by q2 is developed in addition to that given by q1 C in TbNiC2, while the short-range correlation with q2 persists even at 6 K in GdNiC2. The amplitude of the q1 C lattice modulation is anomalously reduced below an antiferromagnetic transition temperature TN in GdNiC2. In contrast, the q2 order vanishes below TN in TbNiC2. We demonstrate that R NiC2 (R = rare earth) compounds exhibit similarities with respect to their CDW phenomena, and discuss the effects of magnetic transitions on CDWs. We offer a possible displacement pattern of the modulated structure characterized by q1 C and q2 in terms of frustration.

  5. Influence of number and depth of magnetic mirror on Alfvénic gap eigenmode

    NASA Astrophysics Data System (ADS)

    Chang, Lei; Hu, Ning; Yao, Jianyao

    2016-10-01

    Alfvénic gap eigenmode (AGE) can eject energetic particles from confinement and thereby threaten the success of magnetically controlled fusion. A low-temperature plasma cylinder is a promising candidate to study this eigenmode, due to easy diagnostic access and simple geometry, and the idea is to arrange a periodic array of magnetic mirrors along the plasma cylinder and introduce a local defect to break the field periodicity. The present work validates this idea by reproducing a clear AGE inside a spectral gap, and more importantly details the influence of the number and depth (or modulation factor) of magnetic mirror on the characteristics of AGE. Results show that AGE is suppressed by other modes inside the spectral gap when the number of magnetic mirrors is below a certain value, which leads to a weakened Bragg’s effect. The structure and frequency of AGE remain unchanged for a decreased number of magnetic mirrors, as long as this number is enough for the AGE formation. The width of spectral gap and decay constant (inverse of decay length) of AGE are linearly proportional to the depth of magnetic mirror, implying easier observation of AGE through a bigger mirror depth. The frequency of AGE shifts to a lower range with the depth increased, possibly due to the unfrozen plasma with field line and the invalidity of small-perturbation analysis. Nevertheless, it is exciting to find that the depth of field modulation can be increased to form AGE for a very limited number of magnetic mirrors. This is of particular interest for the experimental implementation of AGE on a low-temperature plasma cylinder with limited length. Project supported by the National Natural Science Foundation of China (Grant Nos. 11405271, 11372104, 75121543, 11332013, 11372363, and 11502037).

  6. In situ synthesized one-dimensional porous Ni@C nanorods as catalysts for hydrogen storage properties of MgH2.

    PubMed

    An, Cuihua; Liu, Guang; Li, Li; Wang, Ying; Chen, Chengcheng; Wang, Yijing; Jiao, Lifang; Yuan, Huatang

    2014-03-21

    We have demonstrated an extremely facile procedure for the preparation of 1D porous Ni@C nanostructures by pyrolysis of Ni-based coordination polymer nanorods. The highly aligned Ni-based polymer nanorods were prepared using nitrilotriacetic acid (NTA) as a chelating agent by a one-step solvothermal approach. The obtained precursors are demonstrated to have a well-designed 1D nanostructure and a 3D interconnected mesoporous texture. After thermal treatment, 1D porous Ni@C nanorods were obtained, which basically preserved the morphology of the precursors. In addition, the carbon in the porous Ni@C nanorods is in both crystalline and amorphous states. The as-prepared Ni@C sample displays nanorod-like morphology with about 3 μm length and about 200 nm diameter. With a large surface area of 161.4 m(2) g(-1), this novel material had a good catalytic effect on de/hydrogenation of MgH2. The desorption peak temperature of MgH2-5 wt% Ni@C composites can be lowered more than 57 °C than the pure as-milled MgH2. The MgH2-5 wt% Ni@C composite could desorb 6.4 wt% H2 within 10 min at 300 °C, in contrast, only 2.3 wt% H2 was desorbed even after 100 min for pure MgH2. In addition, an activation energy of 108 kJ mol(-1) for the as-milled MgH2-5 wt% Ni@C composites has been obtained, which exhibit an enhanced kinetics.

  7. A preliminary crystallographic study of recombinant NicX, an Fe2+-dependent 2,5-dihydroxypyridine dioxygenase from Pseudomonas putida KT2440

    PubMed Central

    Jiménez, José Ignacio; Acebrón, Iván; García, José Luis; Díaz, Eduardo; Mancheño, José Miguel

    2010-01-01

    NicX from Pseudomonas putida KT2440 is an Fe2+-dependent dioxygenase that is involved in the aerobic degradation of nicotinic acid. The enzyme converts 2,5-­dihydroxypyridine to N-formylmaleamic acid when overexpressed in Escherichia coli. Biophysical characterization of NicX by analytical gel-filtration chromatography revealed that it behaves as an oligomeric assembly in solution, with an apparent molecular weight that is consistent with a hexameric species. NicX was crystallized by the hanging-drop vapour-diffusion method at 291 K. Diffraction data were collected to a resolution of 2.0 Å at the ESRF. The crystals most probably belong to the orthorhombic space group C222 or C2221. The estimated Matthews coefficient was 2.4 Å3 Da−1, corresponding to 50% solvent content, which is consistent with the presence of three protein molecules in the asymmetric unit. Analysis of the crystal data together with chromatographic results supports NicX being a hexameric assembly composed of two cyclic trimers. Currently, crystallization of recombinant selenomethionine-containing NicX is in progress. PMID:20445257

  8. Bidirectional energy cascades and the origin of kinetic Alfvénic and whistler turbulence in the solar wind.

    PubMed

    Che, H; Goldstein, M L; Viñas, A F

    2014-02-14

    The observed steep kinetic scale turbulence spectrum in the solar wind raises the question of how that turbulence originates. Observations of keV energetic electrons during solar quiet time suggest them as a possible source of free energy to drive kinetic turbulence. Using particle-in-cell simulations, we explore how the free energy released by an electron two-stream instability drives Weibel-like electromagnetic waves that excite wave-wave interactions. Consequently, both kinetic Alfvénic and whistler turbulence are excited that evolve through inverse and forward magnetic energy cascades.

  9. Diagnostic and Therapeutic Approaches to Hepatocellular Carcinoma: Understanding the Barcelona Clínic Liver Cancer Protocol

    PubMed Central

    Soldera, Jonathan; Balbinot, Silvana Sartori; Balbinot, Raul Angelo; Cavalcanti, Andreza Gautério

    2016-01-01

    Each year, hepatocellular carcinoma is diagnosed in more than half a million people worldwide and it is the fifth most common cancer in men and the seventh most common cancer in women. This article reviews the Barcelona-Clínic Liver Cancer protocol for the diagnosis, staging, and treatment of this disease, and four cases are presented for the discussion of the therapeutic approach. Understanding the diagnostic and therapeutic approaches to this disease is essential, especially if we keep in mind the quintessential basics of prevention and early detection. PMID:27812296

  10. Venus' night side atmospheric dynamics using near infrared observations from VEx/VIRTIS and TNG/NICS

    NASA Astrophysics Data System (ADS)

    Mota Machado, Pedro; Peralta, Javier; Luz, David; Gonçalves, Ruben; Widemann, Thomas; Oliveira, Joana

    2016-10-01

    We present night side Venus' winds based on coordinated observations carried out with Venus Express' VIRTIS instrument and the Near Infrared Camera (NICS) of the Telescopio Nazionale Galileo (TNG). With NICS camera, we acquired images of the continuum K filter at 2.28 μm, which allows to monitor motions at the Venus' lower cloud level, close to 48 km altitude. We will present final results of cloud tracked winds from ground-based TNG observations and from coordinated space-based VEx/VIRTIS observations.The Venus' lower cloud deck is centred at 48 km of altitude, where fundamental dynamical exchanges that help maintain superrotation are thought to occur. The lower Venusian atmosphere is a strong source of thermal radiation, with the gaseous CO2 component allowing radiation to escape in windows at 1.74 and 2.28 μm. At these wavelengths radiation originates below 35 km and unit opacity is reached at the lower cloud level, close to 48 km. Therefore, it is possible to observe the horizontal cloud structure, with thicker clouds seen silhouetted against the bright thermal background from the low atmosphere. By continuous monitoring of the horizontal cloud structure at 2.28 μm (NICS Kcont filter), it is possible to determine wind fields using the technique of cloud tracking. We acquired a series of short exposures of the Venus disk. Cloud displacements in the night side of Venus were computed taking advantage of a phase correlation semi-automated technique. The Venus apparent diameter at observational dates was greater than 32" allowing a high spatial precision. The 0.13" pixel scale of the NICS narrow field camera allowed to resolve ~3-pixel displacements. The absolute spatial resolution on the disk was ~100 km/px at disk center, and the (0.8–1") seeing-limited resolution was ~400 km/px. By co-adding the best images and cross-correlating regions of clouds the effective resolution was significantly better than the seeing-limited resolution. In order to correct for

  11. Identification and comparison of interventions performed by Korean school nurses and U.S. school nurses using the Nursing Interventions Classification (NIC).

    PubMed

    Lee, Eunjoo; Park, Hyejin; Nam, Mihwa; Whyte, James

    2011-04-01

    The purpose of the study was to identify Nursing Interventions Classification (NIC) interventions performed by Korean school nurses. The Korean data were then compared to U.S. data from other studies in order to identify differences and similarities between Korean and U.S. school nurse practice. Of the 542 available NIC interventions, 180 were selected as the basis of a questionnaire designed to quantify key aspects of school nursing practice. The data were collected from 131 school nurses working in Korea. The results indicated that Korean school nurses focused on classifications from the Physiological Basic domain. Comparisons to previously reported U.S. data reflect that U.S. school nurses focus primarily on the Behavioral domain. The data reflect important differences between the practice characteristics of Korean and U.S. school nurses. Further, the data support the utility of NICs in quantifying the practice characteristics of school nurses in Korea.

  12. NaNet: a configurable NIC bridging the gap between HPC and real-time HEP GPU computing

    NASA Astrophysics Data System (ADS)

    Lonardo, A.; Ameli, F.; Ammendola, R.; Biagioni, A.; Cotta Ramusino, A.; Fiorini, M.; Frezza, O.; Lamanna, G.; Lo Cicero, F.; Martinelli, M.; Neri, I.; Paolucci, P. S.; Pastorelli, E.; Pontisso, L.; Rossetti, D.; Simeone, F.; Simula, F.; Sozzi, M.; Tosoratto, L.; Vicini, P.

    2015-04-01

    NaNet is a FPGA-based PCIe Network Interface Card (NIC) design with GPUDirect and Remote Direct Memory Access (RDMA) capabilities featuring a configurable and extensible set of network channels. The design currently supports both standard—Gbe (1000BASE-T) and 10GbE (10Base-R)—and custom—34 Gbps APElink and 2.5 Gbps deterministic latency KM3link—channels, but its modularity allows for straightforward inclusion of other link technologies. The GPUDirect feature combined with a transport layer offload module and a data stream processing stage makes NaNet a low-latency NIC suitable for real-time GPU processing. In this paper we describe the NaNet architecture and its performances, exhibiting two of its use cases: the GPU-based low-level trigger for the RICH detector in the NA62 experiment at CERN and the on-/off-shore data transport system for the KM3NeT-IT underwater neutrino telescope.

  13. Metal organic framework derived magnetically separable 3-dimensional hierarchical Ni@C nanocomposites: Synthesis and adsorption properties

    NASA Astrophysics Data System (ADS)

    Song, Yixuan; Qiang, Tingting; Ye, Ming; Ma, Qiuyang; Fang, Zhen

    2015-12-01

    Design an effective absorbent that has high surface area, and perfect recyclable is imperative for pollution elimination. Herein, we report a facile two-step strategy to fabricate magnetically separable 3-dimensional (3D) hierarchical carbon-coated nickel (Ni@C) nanocomposites by calcinating nickel based metal organic framework (Ni3(OH)2(C8H4O4)2(H2O)4). SEM and TEM images illuminate that the nanocomposites were constructed by 8 nm nickel nanoparticle encapsulated in 3D flake like carbon. The specific surface area of the obtained nanocomposites is up to 120.38 m2 g-1. Room temperature magnetic measurement indicates the nanocomposites show soft magnetism property, which endows the nanocomposites with an ideal fast magnetic separable property. The maximum adsorption capacity of the nanocomposites for rhodamine B is 84.5 mg g-1. Furthermore, the nanocomposites also exhibit a high adsorption capacity for heavy metal ions. The adsorbent can be very easily separated from the solution by using a common magnet without exterior energy. The as-prepared Ni@C nanocomposites can apply in waste water treatment on a large-scale as a new adsorbent with high efficiency and excellent recyclability.

  14. NaNet: a low-latency NIC enabling GPU-based, real-time low level trigger systems

    NASA Astrophysics Data System (ADS)

    Ammendola, Roberto; Biagioni, Andrea; Fantechi, Riccardo; Frezza, Ottorino; Lamanna, Gianluca; Lo Cicero, Francesca; Lonardo, Alessandro; Stanislao Paolucci, Pier; Pantaleo, Felice; Piandani, Roberto; Pontisso, Luca; Rossetti, Davide; Simula, Francesco; Sozzi, Marco; Tosoratto, Laura; Vicini, Piero

    2014-06-01

    We implemented the NaNet FPGA-based PCIe Gen2 GbE/APElink NIC, featuring GPUDirect RDMA capabilities and UDP protocol management offloading. NaNet is able to receive a UDP input data stream from its GbE interface and redirect it, without any intermediate buffering or CPU intervention, to the memory of a Fermi/Kepler GPU hosted on the same PCIe bus, provided that the two devices share the same upstream root complex. Synthetic benchmarks for latency and bandwidth are presented. We describe how NaNet can be employed in the prototype of the GPU-based RICH low-level trigger processor of the NA62 CERN experiment, to implement the data link between the TEL62 readout boards and the low level trigger processor. Results for the throughput and latency of the integrated system are presented and discussed.

  15. [Implementation of the nursing process in a patient with hepatic cirrhosis using the standardized terminologies NANDA, NIC and NOC].

    PubMed

    Vargas, Rosimeire da Silva; França, Fabiana Cláudia de Vasconcelos

    2007-01-01

    This case study aimed at describing the implementation the implementation of the Nursing Process to a patient with hepatic cirrhosis, and report the difficulties found on the implementation of the assistance. The conceptual model of Horfa was used, NANDA--Nursing Diagnosis, Nursing Interventions Classification (NIC) and Nursing Outcomes Classification (NOC) were also applied in care composition. The present study was developed in a public hospital of Distrito Federal, in September 2005, at the Emergency Unit. Among the identified nursing diagnosis was included: acute confusion, constipation and knowledge deficit. Among the pointed difficulties, it was detached: the disinterest of the nursing team and of the pacient, knowledge deficit and unpreparedness of the professionals, lack of human and material resources to deliver the care.

  16. NaNet: a flexible and configurable low-latency NIC for real-time trigger systems based on GPUs

    NASA Astrophysics Data System (ADS)

    Ammendola, R.; Biagioni, A.; Frezza, O.; Lamanna, G.; Lonardo, A.; Lo Cicero, F.; Paolucci, P. S.; Pantaleo, F.; Rossetti, D.; Simula, F.; Sozzi, M.; Tosoratto, L.; Vicini, P.

    2014-02-01

    NaNet is an FPGA-based PCIe X8 Gen2 NIC supporting 1/10 GbE links and the custom 34 Gbps APElink channel. The design has GPUDirect RDMA capabilities and features a network stack protocol offloading module, making it suitable for building low-latency, real-time GPU-based computing systems. We provide a detailed description of the NaNet hardware modular architecture. Benchmarks for latency and bandwidth for GbE and APElink channels are presented, followed by a performance analysis on the case study of the GPU-based low level trigger for the RICH detector in the NA62 CERN experiment, using either the NaNet GbE and APElink channels. Finally, we give an outline of project future activities.

  17. Theoretical investigation of the ground and low-lying excited states of nickel carbide, NiC.

    PubMed

    Tzeli, Demeter; Mavridis, Aristides

    2007-05-21

    The electronic structure and bonding of 19 states of the diatomic nickel carbide (NiC) has been studied by multireference methods. Potential energy curves have been constructed for all states, whereas for the three lowest states of symmetries X (1)Sigma(+), a (3)Pi, and A (1)Pi well separated from the rest of the states, special attention was paid through the use of very large basis sets and the calculation of core-valence correlation and scalar relativistic effects. The recommended binding energies for these states are 91, 67, and 54 kcal/mol with respect to the ground state atoms. Our results in general can be considered in fair agreement with the limited experimental findings.

  18. Understanding the NMR properties and conformational behavior of indole vs. azaindole group in protoberberines: NICS and NCS analysis

    NASA Astrophysics Data System (ADS)

    Kadam, Shivaji S.; Toušek, Jaromír; Maier, Lukáš; Pipíška, Matej; Sklenář, Vladimír; Marek, Radek

    2012-11-01

    We report here the preparation and the structural investigation into a series of 8-(indol-1-yl)-7,8-dihydroprotoberberine derivatives derived from berberine, palmatine, and coptisine. Structures of these new compounds were characterized mainly by 2D NMR spectroscopy and the conformational behavior was investigated by using methods of density-functional theory (DFT). PBE0/6-311+G** calculated NMR chemical shifts for selected derivatives correlate excellently with the experimental NMR data and support the structural conclusions drawn from the NMR experiments. An interesting role of the nitrogen atom in position N7' of the indole moiety in 8-(7-azaindol-1-yl)-7,8-dihydroprotoberberines as compared to other 8-indolyl derivatives is investigated in detail. The experimentally observed trends in NMR chemical shifts are rationalized by DFT calculations and analysis based on the nucleus-independent chemical shifts (NICS) and natural localized molecular orbitals (NLMOs).

  19. Localization of the nic site of IncN conjugative plasmid pCU1 through formation of a hybrid oriT.

    PubMed

    Paterson, E S; Iyer, V N

    1997-09-01

    The N-type oriT of plasmid pMUR274 was cloned on a 474-bp RsaI-SspI fragment, and the nucleotide sequence was determined. A comparison of the pMUR274 oriT sequence and the sequence of the oriTs of IncN plasmid pCU1 and IncW plasmid R388 demonstrated 57 and 28% identity, respectively. Intramolecular, site-specific recombination between the pCU1 oriT and the oriT of pMUR274 resulted in the formation of a hybrid oriT containing one half of each parental sequence. The junction point of the hybrid occurred within a 10-bp sequence, GCTATACACC, present in both parental sequences and represents the nic site of each oriT. Mutation of the first A or second T residue within the 10-bp junction sequence reduced transfer less than 20-fold, while mutation of either the second or third A residue reduced transfer over 1,000-fold. Site-specific recombination between a wild-type pCU1 oriT and these four mutant pCU1 oriTs demonstrated that nic lies between the second T and second A residues of the 10-bp junction sequence. Site-specific recombination between wild-type and mutant pCU1 oriTs also demonstrated that point mutations to the right of nic reduced both initiation and termination of transfer while point mutations to the left of nic reduced termination but had little or no effect on initiation. A 28-bp deletion within the AT-rich region 39 bases to the right of nic reduced both initiation and termination, while deletion of a 6-bp inverted repeat sequence at the right-most boundary of the minimal oriT region reduced initiation but not termination.

  20. Seasonal mercury transformation and surficial sediment detoxification by bacteria of Marano and Grado lagoons

    NASA Astrophysics Data System (ADS)

    Baldi, Franco; Gallo, Michele; Marchetto, Davide; Fani, Renato; Maida, Isabel; Horvat, Milena; Fajon, Vesna; Zizek, Suzana; Hines, Mark

    2012-11-01

    Marano and Grado lagoons are polluted by mercury from the Isonzo River and a chlor-alkali plant, yet despite this contamination, clam cultivation is one of the main activities in the region. Four stations (MA, MB, MC and GD) were chosen for clam seeding and surficial sediments were monitored in autumn, winter and summer to determine the Hg detoxifying role of bacteria. Biotransformation of Hg species in surficial sediments of Marano and Grado lagoons was investigated while taking into consideration the speciation of organic matter in the biochemical classes of PRT (proteins), CHO (carbohydrates) and LIP (lipids), water-washed cations and anions, bacterial biomass, Hg-resistant bacteria, some specific microbial activities such as sulfate reduction rates, Hg methylation rates, Hg-demethylation rates, and enzymatic ionic Hg reduction. MeHg in sediments was well correlated with PRT content, whereas total Hg in sediments correlated with numbers of Hg-resistant bacteria. Correlations of the latter with Hg-demethylation rates in autumn and winter suggested a direct role Hg-resistant bacteria in Hg detoxification by producing elemental Hg (Hg0) from ionic Hg and probably also from MeHg. MeHg-demethylation rates were ˜10 times higher than Hg methylation rates, were highest in summer and correlated with high sulfate reduction rates indicating that MeHg was probably degraded in summer by sulfate-reducing bacteria via an oxidative pathway. During the summer period, aerobic heterotrophic Hg-resistant bacteria decreased to <2% compared to 53% in winter. Four Hg-resistant bacterial strains were isolated, two Gram-positive (Staphylococcus and Bacillus) and two Gram-negative (Stenotrophomonas and Pseudomonas). Two were able to produce Hg0, but just one contained a merA gene; while other two strains did not produce Hg0 even though they were able to grow at 5 μg ml of HgCl2. Lagoon sediments support a strong sulfur cycle in summer that controls Hg methylation and demethylation

  1. Hydromorphic to subaqueous soils transitions in the central Grado lagoon (Northern Adriatic Sea, Italy)

    NASA Astrophysics Data System (ADS)

    Vittori Antisari, Livia; De Nobili, Maria; Ferronato, Chiara; Natale, Marco; Pellegrini, Elisa; Vianello, Gilmo

    2016-05-01

    The Grado lagoon is among the largest in the Mediterranean sea and is characterized by salt marshes, where tides influenced the development of a complex micromorphology coupled to a micromosaic of vegetation covers. This study represents the first contribution to the understanding of the main processes governing formation, development and spatial transitions between hydromorphic and subaqueous soils in an Adriatic lagoon ecosystem. Physicochemical characteristics and development of soils were investigated in three salt marshes differing for their proximity to the open sea, textural composition and age of formation. Soils of back barrier salt marshes had A/C profiles and were mostly characterized by a sandy coarse texture that allows rapid drainage and subsurface oxygen exchanges. Soil sequences from the inner salt marsh to its submerged border slope or to a brackish waterhole do not simply represent a hydrosequence, but also reflect erosion/sorting/accumulation processes. The soils in the central part of the lagoon have finer texture and in displayed transition or cambic horizons. Silty clay loam textures and low positions allowed the development of more severe anoxic conditions and accumulation of sulphides. The tide oscillation strongly contributed to formation of redoximorphic features, intensity of anaerobic conditions but also colonization by different plant communities. Discriminant analysis was performed to identify physicochemical properties which discriminate the different soils according to geo-morphological position and prevailing plants. It confirmed that differentiation of plant communities occurred according to distinct morphological and physicochemical soil properties, but also acted as a primary affecting factor of pedogenesis.

  2. VEx/VIRTIS and TNG/NICS cloud tracked winds at Venus' lower cloud level using nightside observations

    NASA Astrophysics Data System (ADS)

    Machado, Pedro; Peralta, Javier; Luz, David; Gonçalves, Rúben

    2016-04-01

    We present results based on observations carried out with the Near Infrared Camera and Spectrograph (NICS) of the Telescopio Nazionale Galileo (TNG), in La Palma, on July 2012. We observed for periods of 2.5 hours starting just before dawn, for three consecutive nights. We acquired a set of images of the night side of Venus with the continuum K filter at 2.28 microns, which allows to monitor motions at the lower cloud level of the atmosphere of Venus, close to 48 km altitude. Our objective has been to measure the horizontal wind field in order to characterize the latitudinal zonal wind profile, to study variability, to help constrain the effect of large scale planetary waves in the maintenance of superrotation, and to map the cloud distribution. We will present first results of cloud tracked winds from ground-based TNG observations and winds retrieved from coordinated space-based VEx/VIRTIS observations. The cloud deck extends in altitude from 45 to 70 km, and can be divided into three main regions, centered at 48, 54 and 60 km. The lowest of these is the lower cloud, where fundamental dynamical exchanges that help maintain superrotation are thought to occur. The lower venusian atmosphere is a strong source of thermal radiation, with the gaseaous CO2 component allowing radiation to escape in windows at 1.74 and 2.28 μm. At these wavelengths radiation originates below 35 km, and unit opacity is reached at the lower cloud level, close to 48 km. Therefore, in these windows it is possible to observe the horizontal cloud structure, with thicker clouds seen silhouetted against the bright thermal background from the low atmosphere. Our objective is to provide direct absolute wind measurements and a map of cloud distribution at the lower cloud level in the Venus troposphere, in order to complement Venus Express (VEX) and other ground-based observations of the cloud layer wind regime. By continuous monitoring of the horizontal cloud structure at 2.28 μm (NICS Kcont filter

  3. Near-infrared colors of asteroid 2012 DA14 at its closest approach to Earth: Observations with the Nishiharima Infrared Camera (NIC)

    NASA Astrophysics Data System (ADS)

    Takahashi, Jun; Urakawa, Seitaro; Terai, Tsuyoshi; Hanayama, Hidekazu; Arai, Akira; Honda, Satoshi; Takagi, Yuhei; Itoh, Yoichi; Zenno, Takahiro; Ishiguro, Masateru

    2014-06-01

    We present the results of our JHKs photometry of asteroid 2012 DA14 at its closest approach to Earth on 2013 February 15. Possible spectral changes associated with resurfacing by planetary encounters are of great interest. The Earth flyby of 2012 DA14 provided a rare opportunity to investigate this effect. Our observations were conducted using the Nishiharima Infrared Camera (NIC) attached to the 2.0 m Nayuta telescope at the Nishi-Harima Astronomical Observatory. Despite the extraordinarily fast sky motion of up to near 50″ s-1, the telescope successfully tracked the asteroid. The NIC achievement of three-band simultaneous observations allowed us to reliably deduce the colors of this fast-moving object. The derived near-infrared relative reflectances are flat, which is consistent with the classification of the asteroid as L-type. The J - H and H - Ks colors at 0.5-1 hr after the closest approach are compared with those observed by de León (2013, A&A, 555, L2) at ˜ 10 hr after the closest time. We did not detect color changes significantly exceeding the photometric errors, which are ˜ 0.1 mag. This project has demonstrated the potential of the NIC as a three-band simultaneous imager, especially for observations of rapidly time-variable phenomena.

  4. Western psychology and Muslim psychology in dialogue: comparisons between a Qura'nic theory of personality and Freud's and Jung's ideas.

    PubMed

    Abu-Raiya, Hisham

    2014-04-01

    In this paper, comparisons are made between a newly developed Qura'nic theory of personality and the Freudian and Jungian theories of the mind. Notable similarities were found between the Freudian id, ego, superego and neurosis and the Qura'nic nafs ammarah besoa' (evil-commanding psyche), a'ql (intellect), al-nafs al-lawammah (the reproachful psyche) and al-nafs al-marid'a (the sick psyche), respectively. Noteworthy resemblances were detected also between the Jungian concepts collective unconscious, archetypes, Self and individuation and the Qura'nic constructs roh (spirit), al-asmaa' (the names), qalb (heart), and al-nafs al-mutmainnah (the serene psyche), respectively. These parallels, as well as the departure points, between the models are thoroughly discussed and analyzed. The comparisons performed in this paper open new avenues for dialogue between western models of the psyche and their Muslim counterparts, a dialogue that can enrich both perspectives and advance the field of psychology. PMID:22739812

  5. Nic1 inactivation enables stable isotope labeling with 13C615N4-arginine in Schizosaccharomyces pombe.

    PubMed

    Carpy, Alejandro; Patel, Avinash; Tay, Ye Dee; Hagan, Iain M; Macek, Boris

    2015-01-01

    Stable Isotope Labeling by Amino Acids (SILAC) is a commonly used method in quantitative proteomics. Because of compatibility with trypsin digestion, arginine and lysine are the most widely used amino acids for SILAC labeling. We observed that Schizosaccharomyces pombe (fission yeast) cannot be labeled with a specific form of arginine, (13)C(6) (15)N(4)-arginine (Arg-10), which limits the exploitation of SILAC technology in this model organism. We hypothesized that in the fission yeast the guanidinium group of (13)C(6) (15)N(4)-arginine is catabolized by arginase and urease activity to (15)N1-labeled ammonia that is used as a precursor for general amino acid biosynthesis. We show that disruption of Ni(2+)-dependent urease activity, through deletion of the sole Ni(2+) transporter Nic1, blocks this recycling in ammonium-supplemented EMMG medium to enable (13)C(6) (15)N(4)-arginine labeling for SILAC strategies in S. pombe. Finally, we employed Arg-10 in a triple-SILAC experiment to perform quantitative comparison of G1 + S, M, and G2 cell cycle phases in S. pombe.

  6. THE NONLINEAR AND NONLOCAL LINK BETWEEN MACROSCOPIC ALFVÉNIC AND MICROSCOPIC ELECTROSTATIC SCALES IN THE SOLAR WIND

    SciTech Connect

    Valentini, F.; Vecchio, A.; Donato, S.; Carbone, V.; Veltri, P.; Briand, C.; Bougeret, J.

    2014-06-10

    The local heating of the solar-wind gas during its expansion represents one of the most intriguing problems in space plasma physics and is at present the subject of a relevant scientific effort. The possible mechanisms that could account for local heat production in the interplanetary medium are most likely related to the turbulent character of the solar-wind plasma. Nowadays, many observational and numerical analyses are devoted to the identification of fluctuation channels along which energy is carried from large to short wavelengths during the development of the turbulent cascade; these fluctuation channels establish the link between macroscopic and microscopic scales. In this Letter, by means of a quantitative comparison between in situ measurements in the solar wind from the STEREO spacecraft and numerical results from kinetic simulations, we identify an electrostatic channel of fluctuations that develops along the turbulent cascade in a direction parallel to the ambient magnetic field. This channel appears to be efficient in transferring the energy from large Alfvénic to short electrostatic acoustic-like scales up to a range of wavelengths where it can finally be turned into heat, even when the electron to proton temperature ratio is of the order of unity.

  7. Large amplitude inertial compressional Alfvénic shock and solitary waves, and acceleration of ions in magnetohydrodynamic plasmas

    SciTech Connect

    Panwar, Anuraj; Rizvi, H.; Ryu, C. M.

    2013-05-15

    Large amplitude inertial compressional Alfvénic shock and solitary waves in magnetohydrodynamic plasmas are investigated. Dispersive effect caused by non-ideal electron inertia currents perpendicular to the ambient magnetic field can balance the nonlinear steepening of waves leading to the formation of a soliton. A Sagdeev-potential formalism is employed to derive an energy-balance like equation. The range of allowed values of the soliton speed, M (Mach number), plasma β (ratio of the plasma thermal pressure to the pressure in the confining magnetic field), and electron inertia, wherein solitary waves may exist, are determined. Depth of the potential increases with increasing the Mach number and plasma β, however decreases with the increasing electron inertia. The height of soliton increases with increasing in Mach number and decreases with plasma β. And with increasing electron inertial length, the width of soliton increases. The electron-ion collisional dissipation results a dissipative inertial compressional Alfvén wave, which can produce a shock like structure and can efficiently accelerate ions to the order of the local Alfvén velocity. The shock height increases with the increasing collision frequency, but shock height decreases with increasing plasma β.

  8. The National Ignition Facility (NIF) Diagnostic Set at the Completion of the National Ignition Campaign (NIC) September 2013

    SciTech Connect

    Kilkenny, J.; Bell, P. E.; Bradley, D. K.; Bleuel, D. L.; Caggiano, J. A.; Dewald, E. L.; Hsing, W.; Kalantar, H.; Kauffman, R.; Moody, J. D.; Schneider, M. B.; Shaughnessy, D. A.; Shelton, R. T.; Yeamans, C. B.; Batha, S. H.; Grim, G. P.; Herrmann, H. W.; Merrill, F. E.; Leeper, R. J.; Sangster, T. C.; Edgell, D. H.; Glebov, V. Y.; Regan, S. P.; Frenje, J. A.; Gatu-Johnson, M.; Petrasso, R. D.; Rindernecht, H. G.; Zylstra, A. B.; Cooper, G. W.; Ruiz, C.

    2015-01-05

    At the completion of the National Ignition Campaign NIF had about 36 different types of diagnostics. These were based on several decades of development on Nova and OMEGA and involved the whole US ICF community. A plan for a limited of NIF Diagnostics was documented by the Joint Central Diagnostic Team in the NIF Conceptual Design Report in 1994. These diagnostics and many more were installed diagnostics by two decades later. We give a short description of each of the 36 different types of NIC diagnostics grouped by the function of the diagnostics, namely target drive, target response and target assembly, stagnation and burn. A comparison of NIF diagnostics with the Nova diagnostics shows that the NIF diagnostic capability is broadly equivalent to that of Nova’s in 1999. NIF diagnostics have a much greater degree of automation and rigor than Nova’s and the NIF diagnostic suite incorporates some scientific innovation compared to Nova and OMEGA namely one much higher speed x-ray imager. Directions for future NIF diagnostics are discussed.

  9. Mercury methylation and demethylation in Hg-contaminated lagoon sediments (Marano and Grado Lagoon, Italy)

    NASA Astrophysics Data System (ADS)

    Hines, Mark E.; Poitras, Erin N.; Covelli, Stefano; Faganeli, Jadran; Emili, Andrea; Žižek, Suzana; Horvat, Milena

    2012-11-01

    Mercury (Hg) transformation activities and sulfate (SO42-) reduction were studied in sediments of the Marano and Grado Lagoons in the Northern Adriatic Sea region as part of the "MIRACLE" project. The lagoons, which are sites of clam (Tapes philippinarum) farming, have been receiving excess Hg from the Isonzo River for centuries. Marano Lagoon is also contaminated from a chlor-alkali plant. Radiotracer methods were used to measure mercury methylation (230Hg, 197Hg), methylmercury (MeHg) demethylation (14C-MeHg) and SO42- reduction (35S) in sediment cores collected in autumn, winter and summer. Mercury methylation rate constants ranged from near zero to 0.054 day-1, generally decreased with depth, and were highest in summer. Demethylation rate constants were much higher than methylation reaching values of ˜0.6 day-1 in summer. Demethylation occurred via the oxidative pathway, except in winter when the reductive pathway increased in importance in surficial sediments. Sulfate reduction was also most active in summer (up to 1600 nmol mL-1 day-1) and depth profiles reflected seasonally changing redox conditions near the surface. Methylation and demethylation rate constants correlated positively with SO42- reduction and pore-water Hg concentrations, and inversely with Hg sediment-water partition coefficients indicating the importance of SO42- reduction and Hg dissolution on Hg cycling. Hg transformation rates were calculated using rate constants and concentrations of Hg species. In laboratory experiments, methylation was inhibited by amendments of the SO42--reduction inhibitor molybdate and by nitrate. Lagoon sediments displayed a dynamic seasonal cycle in which Hg dissolution in spring/summer stimulated Hg methylation, which was followed by a net loss of MeHg in autumn from demethylation. Sulfate-reducing bacteria (SRB) tended to be responsible for methylation of Hg and the oxidative demethylation of MeHg. However, during winter in surficial sediments, iron

  10. An analytical model of sub-Alfvénic moon-plasma interactions with application to the hemisphere coupling effect

    NASA Astrophysics Data System (ADS)

    Simon, Sven

    2015-09-01

    We develop a new analytical model of the Alfvén wing that is generated by the interaction between a planetary moon's ionosphere and its magnetospheric environment. While preceding analytical approaches assumed the obstacle's height-integrated ionospheric conductivities to be spatially constant, the model presented here can take into account a continuous conductance profile that follows a power law. The electric potential in the interaction region, determining the electromagnetic fields of the Alfvén wing, can then be calculated from an Euler-type differential equation. In this way, the model allows to include a realistic representation of the "suspension bridge"-like conductance profile expected for the moon's ionosphere. The major drawback of this approach is its restriction to interaction scenarios where the ionospheric Pedersen conductance is large compared to the Hall conductance, and thus, the Alfvénic perturbations are approximately symmetric between the planet-facing and the planet-averted hemispheres of the moon. The model is applied to the hemisphere coupling effect observed at Enceladus, i.e., to the surface currents and the associated magnetic discontinuities that arise from a north-south asymmetry of the obstacle to the plasma flow. We show that the occurrence of this effect is very robust against changes in the conductance profile of Enceladus' plume, and we derive upper limits for the strength of the magnetic field jumps generated by the hemisphere coupling effect. During all 11 reported detections of the hemisphere coupling currents at Enceladus, the observed magnetic field jumps were clearly weaker than the proposed limits. Our findings are also relevant for future in situ studies of putative plumes at the Jovian moon Europa.

  11. Linear benchmarks between the hybrid codes HYMAGYC and HMGC to study energetic particle driven Alfvénic modes

    NASA Astrophysics Data System (ADS)

    Fogaccia, G.; Vlad, G.; Briguglio, S.

    2016-11-01

    Resonant interaction between energetic particles (EPs), produced by fusion reactions and/or additional heating systems, and shear Alfvén modes can destabilize global Alfvénic modes enhancing the EP transport. In order to investigate the EP transport in present and next generation fusion devices, numerical simulations are recognized as a very important tool. Among the various numerical models, the hybrid MHD gyrokinetic one has shown to be a valid compromise between a sufficiently accurate wave-particle interaction description and affordable computational resource requirements. This paper presents a linear benchmark between the hybrid codes HYMAGYC and HMGC. The HYMAGYC code solves the full, linear MHD equations in general curvilinear geometry for the bulk plasma and describes the EP population by the nonlinear gyrokinetic Vlasov equation. On the other side, HMGC solves the nonlinear, reduced O≤ft(ε 03\\right) , pressureless MHD equations ({ε0} being the inverse aspect ratio) for the bulk plasma and the drift kinetic Vlasov equation for the EPs. The results of the HYMAGYC and HMGC codes have been compared both in the MHD limit and in a wide range of the EP parameter space for two test cases (one of which being the so-called TAE n  =  6 ITPA Energetic Particle Group test case), both characterized by {ε0}\\ll 1 . In the first test case (test case A), good qualitative agreement is found w.r.t. real frequencies, growth rates and spatial structures of the most unstable modes, with some quantitative differences for the growth rates. For the so-called ITPA test case (test case B), at the nominal energetic particle density value, the disagreement between the two codes is, on the contrary, also qualitative, as a different mode is found as the most unstable one.

  12. The "Alfvénic surge" at substorm onset/expansion and the formation of "Inverted Vs": Cluster and IMAGE observations

    NASA Astrophysics Data System (ADS)

    Hull, A. J.; Chaston, C. C.; Frey, H. U.; Fillingim, M. O.; Goldstein, M. L.; Bonnell, J. W.; Mozer, F. S.

    2016-05-01

    From multipoint, in situ observations and imaging, we reveal the injection-powered, Alfvénic nature of auroral acceleration during onset and expansion of a substorm. It is shown how Alfvénic variations over time dissipate to form large-scale, inverted-V structures characteristic of quasistatic aurora. This characterization is made possible through the fortuitous occurrence of a substorm onset and expansion phase on field lines traversed by Cluster in the high-altitude acceleration region. Substorm onset was preceded by the occurrence of multiple poleward boundary intensifications (PBIs) and subsequent development/progression of a streamer toward the growth phase arc indicating that this is of the PBI-/streamer-triggered class of substorms. Onset on Cluster is marked by the injection of hot, dense magnetospheric plasma in a region tied to one of the preexisting PBI current systems. This was accompanied by a surge of Alfvénic activity and enhanced inverted-V acceleration, as the PBI current system intensified and striated to dispersive scale Alfvén waves. The growth of Alfvén wave activity was significant (up to a factor of 300 increase in magnetic field power spectral density at frequencies 20 mHz ≲f≲ few hertz) and coincided with moderate growth (factor 3-5) in the background PBI current. This sequence is indicative of a cascade process whereby small-scale/dispersive Alfvén waves are generated from large-scale Alfvén waves or current destabilization. It also demonstrates that the initial PBIs and their subsequent evolution are an intrinsic part of the global auroral substorm response to injection and accompanying wave energy input from the magnetotail. Alfvénic activity persisted poleward of the PBI currents composing a broad Alfvén wave-dominated region extending to the polar cap edge. These waves have transverse scales ranging from a few tens of kilometers to below the ion gyroradius and are associated with large electric fields (up to 200 mV/m) and

  13. Change of Magnetic Field-gas Alignment at the Gravity-driven Alfvénic Transition in Molecular Clouds: Implications for Dust Polarization Observations

    NASA Astrophysics Data System (ADS)

    Chen, Che-Yu; King, Patrick K.; Li, Zhi-Yun

    2016-10-01

    Diffuse striations in molecular clouds are preferentially aligned with local magnetic fields, whereas dense filaments tend to be perpendicular to them. When and why this transition occurs remain uncertain. To explore the physics behind this transition, we compute the histogram of relative orientation (HRO) between the density gradient and the magnetic field in three-dimensional magnetohydrodynamic (MHD) simulations of prestellar core formation in shock-compressed regions within giant molecular clouds. We find that, in the magnetically dominated (sub-Alfvénic) post-shock region, the gas structure is preferentially aligned with the local magnetic field. For overdense sub-regions with super-Alfvénic gas, their elongation becomes preferentially perpendicular to the local magnetic field. The transition occurs when self-gravitating gas gains enough kinetic energy from the gravitational acceleration to overcome the magnetic support against the cross-field contraction, which results in a power-law increase of the field strength with density. Similar results can be drawn from HROs in projected two-dimensional maps with integrated column densities and synthetic polarized dust emission. We quantitatively analyze our simulated polarization properties, and interpret the reduced polarization fraction at high column densities as the result of increased distortion of magnetic field directions in trans- or super-Alfvénic gas. Furthermore, we introduce measures of the inclination and tangledness of the magnetic field along the line of sight as the controlling factors of the polarization fraction. Observations of the polarization fraction and angle dispersion can therefore be utilized in studying local magnetic field morphology in star-forming regions.

  14. Benthic flux measurements of Hg species in a northern Adriatic lagoon environment (Marano and Grado Lagoon, Italy)

    NASA Astrophysics Data System (ADS)

    Emili, Andrea; Acquavita, Alessandro; Koron, Neža; Covelli, Stefano; Faganeli, Jadran; Horvat, Milena; Žižek, Suzana; Fajon, Vesna

    2012-11-01

    As part of the "MIRACLE" project, the biogeochemical cycling of mercury (Hg) at the sediment-water interface was studied in the field in the Marano and Grado Lagoon (Northern Adriatic Sea). Seasonal investigations were conducted at selected experimental sites, where Manila Clams (Tapes philippinarum) were previously seeded. Measurements were performed seasonally during three campaigns, using two benthic chambers, one transparent and one dark, to evaluate the effect of light on Hg cycling. Total dissolved Hg (THg), methylmercury (MeHg), and dissolved gaseous Hg (DGM) species were considered. Diurnal benthic fluxes were found to significantly exceed the diffusive fluxes at all stations. The assessment of the annual recycling of Hg species from sediments to the water column showed that up to 99% of MeHg is recycled annually to the water column, while Hg recycling ranges from 30 to 60%. MeHg poses the higher risk for potential bioaccumulation in clams, but it is partially mitigated by Hg reduction, which seems to be an important process leading to evasion losses of Hg from these environments. Estimated benthic fluxes suggest that Hg recycling at the sediment-water interface is more active in the Grado sector. Hence, based on the estimated release of MeHg from sediments, it is suggested that the western sector seems to be more suitable for clam farming and the extension of rearing activities.

  15. Manila clams from Hg polluted sediments of Marano and Grado lagoons (Italy) harbor detoxifying Hg resistant bacteria in soft tissues.

    PubMed

    Baldi, Franco; Gallo, Michele; Marchetto, Davide; Faleri, Claudia; Maida, Isabel; Fani, Renato

    2013-08-01

    A mechanism of mercury detoxification has been suggested by a previous study on Hg bioaccumulation in Manila clams (Ruditapes philippinarum) in the polluted Marano and Grado lagoons and in this study we demonstrate that this event could be partly related to the detoxifying activities of Hg-resistant bacteria (MRB) harbored in clam soft tissues. Therefore, natural clams were collected in six stations during two different periods (winter and spring) from Marano and Grado Lagoons. Siphons, gills and hepatopancreas from acclimatized clams were sterile dissected to isolate MRB. These anatomical parts were glass homogenized or used for whole, and they were lying on a solid medium containing 5mgl(-1) HgCl2 and incubated at 30°C. A total of fourteen bacterial strains were isolated and were identified by 16S rDNA sequencing and analysis, revealing that strains were representative of eight bacterial genera, four of which were Gram-positive (Enterococcus, Bacillus, Jeotgalicoccus and Staphylococcus) and other four were Gram-negative (Stenotrophomonas, Vibrio, Raoultella and Enterobacter). Plasmids and merA genes were found and their sequences determined. Fluorescence in situ hybridization (FISH) technique shows the presence of Firmicutes, Actinobacteria and Gammaproteobacteria by using different molecular probes in siphon and gills. Bacterial clumps inside clam flesh were observed and even a Gram-negative endosymbiont was disclosed by transmission electronic microscope inside clam cells. Bacteria harbored in cavities of soft tissue have mercury detoxifying activity. This feature was confirmed by the determination of mercuric reductase in glass-homogenized siphons and gills.

  16. Core-localized Alfvénic modes driven by energetic ions in HL-2A NBI plasmas with weak magnetic shears

    NASA Astrophysics Data System (ADS)

    Chen, W.; Yu, L. M.; Ding, X. T.; Xie, H. S.; Shi, Z. B.; Ji, X. Q.; Yu, D. L.; Zhang, Y. P.; Shi, P. W.; Li, Y. G.; Feng, B. B.; Jiang, M.; Zhong, W. L.; Cao, J. Y.; Song, X. M.; Xu, M.; Xu, Y. H.; Yan, L. W.; Liu, Yi; Yang, Q. W.; Duan, X. R.; HL-2A Team

    2016-03-01

    Recent experimental results that are associated with the core-localized (i.e. normalized radius ρ =r/a<0.5 ) Alfvénic modes in HL-2A neutral beam injection (NBI) plasmas with weak magnetic shears are reported. In the different plasma parameter regions, the energetic ions produced by the NBI drive multiple Alfvénic instabilities, such as the toroidal Alfvén eigenmode (TAE), beta-induced Alfvén eigenmode, reversed shear Alfvén eigenmode (RSAE) and fishbone and energetic particle mode (EPM). Here, we focus on the high-frequency RSAE (HFRSAE) and resonant kinetic ballooning mode (rKBM). A group of downward-sweeping frequency coherent modes (HFRSAEs) with 100  <  f  <  500 kHz and n  =  3-7 are often observed with an increase in the edge safety factor, q a . Their measured frequency is more than that of the TAEs, and {{f}\\text{min}}˜ {{f}\\text{TAE}} . The analysis suggests that these modes localize inside the high-order Alfvén eigenmode (AE) gap of the Alfvénic continuum, and their eigenfrequency and eigenfunction depend on the {{q}\\text{min}} and q-profile. When the core plasma density is more than {{n}e0}>3.0× {{10}19} m-3 and the impurity or supersonic molecular beam enters the bulk plasma, the profiles of the plasma density/pressure peak, and the magnetic shear is weak or negative. In this case, a group of multi-harmonic coherent modes (rKBMs) with 30  <  f  <  150 kHz and n  =  2-9 are observed through multiple diagnostic techniques, and {{f}\\ast pi}/2<{{f}\\text{MHD}}={{f}\\text{lab}}-n{{f}vφ}<{{f}\\ast pi} , where {{f}\\ast pi}={ω\\ast pi}/2π is the diamagnetic drift frequency of the thermal ion. It is found that the HFRSAEs can transit into the rKBMs when the density profile suddenly peaks. Neutron monitoring outside the vacuum chamber demonstrates that the HFRSAE and rKBM both degrade the confinement of the energetic ions. The rKBM instabilities also affect the bulk plasma performance.

  17. A new room-temperature ultraviolet emission material: K2[Ni(C2O4)2(H2O)2]·4H2O

    NASA Astrophysics Data System (ADS)

    Narsimhulu, M.; Raju, B.; Saritha, A.; Narayana Rao, D.; Hussain, K. A.

    2015-09-01

    In this study, we investigated the crystal structure, ultraviolet (UV) luminescence, and magnetic properties of potassium bis oxalate nickel(II) tetrahydrate {K2[Ni(C2O4)2(H2O)2]·4H2O} crystals. This compound crystallizes in the monoclinic system with a P21/c space group and exhibits a one-dimensional (1D) chain structure. The Ni(II) metal center possesses an octahedral environment, with four oxygen atoms from two bidentate oxalate ligands and two oxygen atoms from water molecules. Infrared spectroscopy was used to study the vibrational modes of the compound. Interestingly, the complex exhibits intense UV emission at 364 nm when excited at 323 nm. Furthermore, the luminescence lifetime is approximately 50 μs. The magnetic susceptibility and field dependent magnetization measurements revealed a paramagnetic behavior above 20 K and antiferromagnetic ordering at low temperatures.

  18. Magnetic properties of Ni(C 5H 5N) 2Ni(CN) 4 - 2d S = 1 Heisenberg magnet with easy-axis anisotropy

    NASA Astrophysics Data System (ADS)

    Čižmár, E.; Kačmár, M.; Orendáč, M.; Orendáčová, A.; Černák, J.; Feher, A.

    1999-05-01

    Specific heat studies of structurally layered powdered Ni(C 5H 5N) 2Ni(CN) 4 have been carried out from 100 mK to 2.5 K in zero magnetic field. A λ-like anomaly with a strong rounding-off observed at 0.9 K might be ascribed to the phase transition into the magnetically ordered state. Consequently, easy-axis type of anisotropy introduced by C 5H 5N enabled analysing the system using a 2d S = {1}/{2} Ising model for the square lattice and a Schottky anomaly yielding D/ kB = - 1.9 K and | J/ kB| = 0.35 K.

  19. Manila clams from Hg polluted sediments of Marano and Grado lagoons (Italy) harbor detoxifying Hg resistant bacteria in soft tissues

    SciTech Connect

    Baldi, Franco; Gallo, Michele; Marchetto, Davide; Faleri, Claudia; Maida, Isabel; Fani, Renato

    2013-08-15

    A mechanism of mercury detoxification has been suggested by a previous study on Hg bioaccumulation in Manila clams (Ruditapes philippinarum) in the polluted Marano and Grado lagoons and in this study we demonstrate that this event could be partly related to the detoxifying activities of Hg-resistant bacteria (MRB) harbored in clam soft tissues. Therefore, natural clams were collected in six stations during two different periods (winter and spring) from Marano and Grado Lagoons. Siphons, gills and hepatopancreas from acclimatized clams were sterile dissected to isolate MRB. These anatomical parts were glass homogenized or used for whole, and they were lying on a solid medium containing 5 mg l{sup −1} HgCl{sub 2} and incubated at 30 °C. A total of fourteen bacterial strains were isolated and were identified by 16S rDNA sequencing and analysis, revealing that strains were representative of eight bacterial genera, four of which were Gram-positive (Enterococcus, Bacillus, Jeotgalicoccus and Staphylococcus) and other four were Gram-negative (Stenotrophomonas, Vibrio, Raoultella and Enterobacter). Plasmids and merA genes were found and their sequences determined. Fluorescence in situ hybridization (FISH) technique shows the presence of Firmicutes, Actinobacteria and Gammaproteobacteria by using different molecular probes in siphon and gills. Bacterial clumps inside clam flesh were observed and even a Gram-negative endosymbiont was disclosed by transmission electronic microscope inside clam cells. Bacteria harbored in cavities of soft tissue have mercury detoxifying activity. This feature was confirmed by the determination of mercuric reductase in glass-homogenized siphons and gills. -- Highlights: ► We isolated Gram-positive and Gram-negative Hg resistant strains from soft tissues of Ruditapes philippinarum. ► We identify 14 mercury resistant strains by 16S rRNA gene sequences. ► Bacteria in siphon and gill tissues of clams were observed by TEM and identified

  20. Discovery of Dark pH-Dependent H(+) Migration in a [NiFe]-Hydrogenase and Its Mechanistic Relevance: Mobilizing the Hydrido Ligand of the Ni-C Intermediate.

    PubMed

    Murphy, Bonnie J; Hidalgo, Ricardo; Roessler, Maxie M; Evans, Rhiannon M; Ash, Philip A; Myers, William K; Vincent, Kylie A; Armstrong, Fraser A

    2015-07-01

    Despite extensive studies on [NiFe]-hydrogenases, the mechanism by which these enzymes produce and activate H2 so efficiently remains unclear. A well-known EPR-active state produced under H2 and known as Ni-C is assigned as a Ni(III)-Fe(II) species with a hydrido ligand in the bridging position between the two metals. It has long been known that low-temperature photolysis of Ni-C yields distinctive EPR-active states, collectively termed Ni-L, that are attributed to migration of the bridging-H species as a proton; however, Ni-L has mainly been regarded as an artifact with no mechanistic relevance. It is now demonstrated, based on EPR and infrared spectroscopic studies, that the Ni-C to Ni-L interconversion in Hydrogenase-1 (Hyd-1) from Escherichia coli is a pH-dependent process that proceeds readily in the dark-proton migration from Ni-C being favored as the pH is increased. The persistence of Ni-L in Hyd-1 must relate to unassigned differences in proton affinities of metal and adjacent amino acid sites, although the unusually high reduction potentials of the adjacent Fe-S centers in this O2-tolerant hydrogenase might also be a contributory factor, impeding elementary electron transfer off the [NiFe] site after proton departure. The results provide compelling evidence that Ni-L is a true, albeit elusive, catalytic intermediate of [NiFe]-hydrogenases.

  1. Magnetospheric Multiscale Mission observations and non-force free modeling of a flux transfer event immersed in a super-Alfvénic flow

    NASA Astrophysics Data System (ADS)

    Farrugia, C. J.; Lavraud, B.; Torbert, R. B.; Argall, M.; Kacem, I.; Yu, W.; Alm, L.; Burch, J.; Russell, C. T.; Shuster, J.; Dorelli, J.; Eastwood, J. P.; Ergun, R. E.; Fuselier, S.; Gershman, D.; Giles, B. L.; Khotyaintsev, Y. V.; Lindqvist, P. A.; Matsui, H.; Marklund, G. T.; Phan, T. D.; Paulson, K.; Pollock, C.; Strangeway, R. J.

    2016-06-01

    We analyze plasma, magnetic field, and electric field data for a flux transfer event (FTE) to highlight improvements in our understanding of these transient reconnection signatures resulting from high-resolution data. The ˜20 s long, reverse FTE, which occurred south of the geomagnetic equator near dusk, was immersed in super-Alfvénic flow. The field line twist is illustrated by the behavior of flows parallel/perpendicular to the magnetic field. Four-spacecraft timing and energetic particle pitch angle anisotropies indicate a flux rope (FR) connected to the Northern Hemisphere and moving southeast. The flow forces evidently overcame the magnetic tension. The high-speed flows inside the FR were different from those outside. The external flows were perpendicular to the field as expected for draping of the external field around the FR. Modeling the FR analytically, we adopt a non-force free approach since the current perpendicular to the field is nonzero. It reproduces many features of the observations.

  2. Cloud tracked winds at the lower cloud level using Venus' night side observations at 2.28 μm with TNG/NICS

    NASA Astrophysics Data System (ADS)

    Machado, P.; Luz, D.; Oliveira, J.; Peralta, J.

    2015-10-01

    We present results based on observations carried out with the Near Infrared Camera and Spectrograph(NICS) of the Telescopio Nazionale Galileo (TNG), in La Palma, on July 2012. We observed for periods of 2.5 hours starting just before dawn, for three consecutive nights. We acquired a set of images of the night side of Venus with the continuum K filter at 2.28 microns, which allows to monitor motions at the lower cloud level of the atmosphere of Venus, close to 48 km altitude. Our objective has been to measure the horizontal wind field in order to characterize the latitudinal zonal wind profile, to study variability, to help constrain the effect of large scale planetary waves in the maintenance of superrotation, and to map the cloud distribution. These observations were part of the network of ground-based observations of Venus coordinated with ESA's Venus Express orbiter for the 2012 Venus transit campaign. Ground-based observa- tions are complementary to orbiter measurements, allowing simultaneous determination of the winds. We will present first results of cloud tracked winds from ground-based TNG observations and winds retrieved from coordinated space-based VEx/VIRTIS observations.

  3. Haldane-gap excitations in the low-Hc one-dimensional quantum antiferromagnet Ni(C5D14N2)2N3(PF6)

    NASA Astrophysics Data System (ADS)

    Zheludev, A.; Chen, Y.; Broholm, C. L.; Honda, Z.; Katsumata, K.

    2001-03-01

    Inelastic neutron scattering on deuterated single-crystal samples is used to study Haldane-gap excitations in the new S=1 one-dimensional quantum antiferromagnet Ni(C5D14N2)2N3(PF6), that was recently recognized as an ideal model system for high-field studies. The Haldane gap energies Δx=0.42(3) meV, Δy=0.52(6) meV, and Δz=1.9(1) meV, for excitations polarized along the a, b, and c crystallographic axes, respectively, are measured. The dispersion relation is studied for momentum transfers both along and perpendicular to the chains' direction. The in-chain exchange constant J=2.8 meV is found to be much larger than interchain coupling, Jy=1.8(4)×10-3 meV and Jx=4(3)×10-4 meV, along the b and a axes, respectively. The results are discussed in the context of future experiments in high magnetic fields.

  4. Statistical altitude distribution of Cluster auroral electric fields, indicating mainly quasi-static acceleration below 2.8 RE and Alfvénic above

    NASA Astrophysics Data System (ADS)

    Li, B.; Marklund, G.; Alm, L.; Karlsson, T.; Lindqvist, P.-A.; Masson, A.

    2014-11-01

    Results are presented from a statistical study of high-altitude electric fields and plasma densities using Cluster satellite data collected during 9.5 years between 2 and 4 RE. The average electric fields are most intense on the nightside and associated with an extensive plasma density cavity, with densities of 1 cm-3 or less. The intense electric fields are concentrated in two regions, separated by an altitude gap at about 2.8 RE. Below this, the average electric field magnitudes reach about 50 mV/m (mapped to the ionosphere) between 22 and 01 magnetic local time (MLT). Above 3 RE, the fields are about twice as high and spread over a broader MLT range. These fields occur in a region where the (ΔE/ΔB)/VA ratio is close to unity, which suggests an Alfvénic origin. The intense low-altitude electric fields are interpreted to be quasi-static, associated with the auroral acceleration region. This is supported by their location in MLT and altitude, and by a (ΔE/ΔB)/VA ratio much below unity. The local electric field minimum between the two regions indicates a partial closure of the electrostatic potentials in the lower region. These results show similarities with model results of reflected Alfvén waves by Lysak and Dum (1983), and with the O-shaped potential model, with associated wave-particle interaction at its top, proposed by Janhunen et al. (2000).

  5. Human impact and the historical transformation of saltmarshes in the Marano and Grado Lagoon, northern Adriatic Sea

    NASA Astrophysics Data System (ADS)

    Fontolan, Giorgio; Pillon, Simone; Bezzi, Annelore; Villalta, Renato; Lipizer, Marco; Triches, Antonella; D'Aietti, Alessandro

    2012-11-01

    Historical transformations of the saltmarshes in the six sub-basins of the Marano and Grado Lagoon were analyzed using aerial photographs (1954, 1990, 2006), and the support of historical maps and topographic surveys. Analysis of the 2006 set of aerial photographs enabled the definition of the present extent and distribution of the saltmarshes inside the lagoon (760 ha), with a total reduction in saltmarsh area of 16% (144 ha) compared to 1954. Direct human actions played a significant role in the budget, since total loss due to land reclamation and dredging during this period amounted to 126 ha. After excluding the total loss due to direct human interventions, different erosional and depositional marsh types were recognized and associated with different forcing factors, based on morphological and geographical evidence. Over the 52-year period marshes were lost due to: (a) drowning - the combined effects of eustatism, regional subsidence and autocompaction (102 ha); (b) edge-retreat by wind wave attack (34 ha); (c) erosion by vessel-generated waves (37 ha); and (d) coastal dynamics and inlet migration (5.7 ha). Conversely, marshes gained in area due to: (a) fluvial input (63 ha); (b) tidal input (27 ha); (c) paralagoonal deposition (45 ha); (d) the re-opening of abandoned fish farms (18 ha); and (e) the dumping of dredged material (8 ha). Our analysis demonstrates that local and short-term forcing factors can obliterate or compensate the long-term ones, especially the relative sea-level rise. A test of the integrated sediment budget carried out on one third of the total lagoon, through a bathymetric comparison between datasets from 1964 to 2009, pointed out that conservation or slight expansion of the marshes inside these basins were linked to an overall positive sediment budget of 61,000 m3/y. Nevertheless, significant morphological changes occurred in the submerged basin, which is affected by sustained deposition along the inner margins due to sediment supplies

  6. Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado.

    PubMed

    Williams, J E

    2001-12-01

    Viral diseases, including emerging and chronic viruses, are an increasing worldwide health concern. As a consequence, the discovery of new antiviral agents from plants has assumed more urgency than in the past. A number of native Amazonian medicines of plant origin are known to have antimicrobial and anti-inflammatory activity, although only a few have been studied for their antiviral properties and immunomodulating effects. Those most studied include: Sangre de Grado (drago) (Croton lechleri) in the Euphorbiaceae family and Una de Gato (Uncaria tomentosa) in the Rubiaceae family. This article reviews the chemical composition, pharmacological properties, state of current research, clinical use, and potential antiviral and immunomodulating activity of these and other plants from the Peruvian Amazon.

  7. The PAH level, distribution and composition in surface sediments from a Mediterranean lagoon: the Marano and Grado Lagoon (Northern Adriatic Sea, Italy).

    PubMed

    Acquavita, Alessandro; Falomo, Jari; Predonzani, Sergio; Tamberlich, Francesco; Bettoso, Nicola; Mattassi, Giorgio

    2014-04-15

    The Marano and Grado Lagoon is one of the best conserved transitional environment in the whole Mediterranean area. On the other hand, it suffers from industrial, agricultural and fisheries activities, which could have an important impact on its environmental quality. With the application of the WFD, the sediment chemical status was investigated. In this work, 16 polycyclic aromatic hydrocarbons included by the US EPA within the priority pollutants were considered. PAHs values ranged from non-detectable to 1056 ng g(-1) showing the highest contamination close to the Aussa-Corno River mouth, which received the industrial inputs. The contamination level was comparable to that observed in low contaminated sites of the Mediterranean region, and lower than the adjacent Gulf of Trieste. The ratios of selected PAHs congeners pointed out the prevalence of pyrolitic sources. Moreover, the application of the ERL/ERM displayed an environment, which should not have a potential biological impact.

  8. Modeling Study of the Marano and Grado Lagoon (Italy) to Support the Regional Water Protection Plan) TO SUPPORT THE REGIONAL WATER PROTECTION PLAN

    NASA Astrophysics Data System (ADS)

    Scroccaro, Isabella; Mattassi, Giorgio

    2014-05-01

    The Water Framework Directive 2000/60/EC (WFD) contemplates the classification of water bodies and establishes the quality objectives of water bodies to achieve a good status within 2015. Further, the Italian law which takes in the WFD with Decree n. 152/2006, allows to identify some water bodies as heavily modified (HMWB). The Regional Administration, involved in the setting up of the Water Protection Plan, according with the above mentioned decree and directive, has to establish specific programs to maintain or conform water quality to the requested quality objectives, also for heavily modified water bodies that have to reach the ecological potential. In the north-eastern part of Italy, in the Friuli Venezia Giulia Region, the Marano and Grado Lagoon is the most complex transitional ecosystem in which four water bodies have been temporarily classified as heavily modified. They are identified as FM1, FM2, FM3 and FM4. In particular, FM2 - "Paludo della Carogna" and FM3 - "Barbana" water bodies seem to be characterized by some confinement since they are delimited by a bridge, called "Ponte Belvedere". The preliminary evaluation of the quality status of FM2 and FM3 water bodies is conditioned by the value of one of the quality criteria: the macrophytes. In fact, macrophytes are represented by very few species in these two water bodies. In a preliminary way the overall judgement of FM2 and FM3 water bodies has been indicated by the experts as scarse. This means that a specific programme of measures has to be proposed to improve the quality status of these water bodies in order to reach the ecological potential. In this context modeling may be used as a scientific and technical tool to support the evaluation on FM2 and FM3 water bodies and the effectiveness of specific measures for the achievement of the quality objectives. Numerical simulations of the Marano and Grado lagoon were performed for hydrodynamic circulation, temperature and salinity behavior with the

  9. Nup93, a Vertebrate Homologue of Yeast Nic96p, Forms a Complex with a Novel 205-kDa Protein and Is Required for Correct Nuclear Pore Assembly

    PubMed Central

    Grandi, Paola; Dang, Tam; Pané, Nelly; Shevchenko, Andrej; Mann, Matthias; Forbes, Douglass; Hurt, Ed

    1997-01-01

    Yeast and vertebrate nuclear pores display significant morphological similarity by electron microscopy, but sequence similarity between the respective proteins has been more difficult to observe. Herein we have identified a vertebrate nucleoporin, Nup93, in both human and Xenopus that has proved to be an evolutionarily related homologue of the yeast nucleoporin Nic96p. Polyclonal antiserum to human Nup93 detects corresponding proteins in human, rat, and Xenopus cells. Immunofluorescence and immunoelectron microscopy localize vertebrate Nup93 at the nuclear basket and at or near the nuclear entry to the gated channel of the pore. Immunoprecipitation from both mammalian and Xenopus cell extracts indicates that a small fraction of Nup93 physically interacts with the nucleoporin p62, just as yeast Nic96p interacts with the yeast p62 homologue. However, a large fraction of vertebrate Nup93 is extracted from pores and is also present in Xenopus egg extracts in complex with a newly discovered 205-kDa protein. Mass spectrometric sequencing of the human 205-kDa protein reveals that this protein is encoded by an open reading frame, KIAAO225, present in the human database. The putative human nucleoporin of 205 kDa has related sequence homologues in Caenorhabditis elegans and Saccharomyces cerevisiae. To analyze the role of the Nup93 complex in the pore, nuclei were assembled that lack the Nup93 complex after immunodepletion of a Xenopus nuclear reconstitution extract. The Nup93-complex–depleted nuclei are clearly defective for correct nuclear pore assembly. From these experiments, we conclude that the vertebrate and yeast pore have significant homology in their functionally important cores and that, with the identification of Nup93 and the 205-kDa protein, we have extended the knowledge of the nearest-neighbor interactions of this core in both yeast and vertebrates. PMID:9348540

  10. Bis(phenyl-phospho-nic) anhydride.

    PubMed

    Li, Yang; Hua, Guoxiong; Slawin, Alexandra M Z; Woollins, J Derek

    2009-10-03

    The asymmetric unit of the title compound, C(12)H(12)O(5)P(2), contains four independent mol-ecules, generating two dimers via pairs of inter-molecular O-H⋯O hydrogen bonds, forming R(2) (2)(8) rings. The two aryl rings of each mol-ecule form dihedral angles of 108.6 (1), 103.2 (1), 12.5 (2) and 8.1 (2)° in the four mol-ecules.

  11. Characterization of nicergoline polymorphs crystallized in several organic solvents.

    PubMed

    Malaj, Ledjan; Censi, Roberta; Capsoni, Doretta; Pellegrino, Luca; Bini, Marcella; Ferrari, Stefania; Gobetto, Roberto; Massarotti, Vincenzo; Di Martino, Piera

    2011-07-01

    Nicergoline (NIC), a poorly water-soluble semisynthetic ergot derivative, was crystallized from several organic solvents, obtaining two different polymorphic forms, the triclinic form I and the orthorhombic form II. NIC samples were then characterized by several techniques such as (13)C cross-polarization magic angle spinning solid-state spectroscopy, room-temperature and high-temperature X-ray powder diffraction, differential scanning calorimetry, and by analysis of weight loss, solvent content, powder density, morphology, and particle size. Solubility and intrinsic dissolution rates determined for the two polymorphic forms in water and hydrochloride solutions (HCl 0.1 N) were always higher for form II than for form I, which is actually the form used for the industrial preparation of NIC medicinal products. Preformulation studies might encourage industry for the evaluation of polymorph II, as it is more suitable for pharmaceutical applications. Results in drug delivery, as well as those obtained by the above-mentioned techniques, and the application of Burger-Ramberger's rules make it possible to conclude that there is a thermodynamic relation of monotropy between the two polymorphs. This last assumption may help formulators in predicting the relative stability of the two forms. PMID:21254066

  12. Characterization of nicergoline polymorphs crystallized in several organic solvents.

    PubMed

    Malaj, Ledjan; Censi, Roberta; Capsoni, Doretta; Pellegrino, Luca; Bini, Marcella; Ferrari, Stefania; Gobetto, Roberto; Massarotti, Vincenzo; Di Martino, Piera

    2011-07-01

    Nicergoline (NIC), a poorly water-soluble semisynthetic ergot derivative, was crystallized from several organic solvents, obtaining two different polymorphic forms, the triclinic form I and the orthorhombic form II. NIC samples were then characterized by several techniques such as (13)C cross-polarization magic angle spinning solid-state spectroscopy, room-temperature and high-temperature X-ray powder diffraction, differential scanning calorimetry, and by analysis of weight loss, solvent content, powder density, morphology, and particle size. Solubility and intrinsic dissolution rates determined for the two polymorphic forms in water and hydrochloride solutions (HCl 0.1 N) were always higher for form II than for form I, which is actually the form used for the industrial preparation of NIC medicinal products. Preformulation studies might encourage industry for the evaluation of polymorph II, as it is more suitable for pharmaceutical applications. Results in drug delivery, as well as those obtained by the above-mentioned techniques, and the application of Burger-Ramberger's rules make it possible to conclude that there is a thermodynamic relation of monotropy between the two polymorphs. This last assumption may help formulators in predicting the relative stability of the two forms.

  13. El rol de Ia colaboracion y el Modelo de Aprendizaje Basado en Proyectos (ABPr) mediante el lente de la Teoria de Actividad (CHAT): un estudio de caso con estudiantes de 9no grado

    NASA Astrophysics Data System (ADS)

    Delgado, Isabel C.

    Los modelos de eensenanza y aprendizaje constructivistas conceptualizan el aprendizaje como un proceso activo. El modelo de Aprendizaje Basado en Proyectos (ABPr) se distingue por una serie de componentes, entre los cuales se destaca el aspecto colaborativo y cooperativo como un reto al momento de su implantacion. Son pocas las investigaciones que se concentran en este aspecto del modelo. En este estudio, se analizaron las diversas interacciones que surgen durante la implantacion de una unidad curricular sobre el tema de Geologia de Puerto Rico, la cual se diseno con el modelo ABPr cuyo enfoque es orientacion a proyectos. Particularmente, se examinaron las interacciones sociales que surgen entre los pares y entre pares y docente durante el proceso de planificacion y desarrollo de los productos finales, al igual que las interacciones entre los estudiantes y el material didactico en estas etapas del modelo. La investigacion es de tipo cualitativo e incorpora como diseno el estudio de caso. Las diversas interacciones constituyen la unidad de analisis. En el estudio participaron 19 estudiantes de 9no grado, a quienes se organizaron en 5 grupos colaborativos por temas de interes (Pangea, Placas tectonicas, Volcanes, Tsunamis y Terremotos). Las tecnicas que se utilizaron para recopilar los datos fueron: observaciones participativas, grupos focales y analisis de documentos (cuadernos reflexivos y respuestas de los estudiantes a la pregunta central del proyecto). Para el analisis de los datos se aplico la teoria de actividad (CHAT) que concentra la unidad de analisis en la actividad humana en un contexto particular. Los resultados del estudio senalan que las interacciones entre pares, entre pares y docente, asi como entre estudiantes y material didactico son fundamentales en el proceso de aprendizaje. Una mayor interaccion entre pares durante las etapas de planificar y desarrollar los productos finales de la unidad, promueve una mejor comprension de los conceptos de la

  14. High-Density Carbon (HDC) Ablator for NIC Ignition Capsules

    NASA Astrophysics Data System (ADS)

    Ho, D.; Haan, S.; Salmonson, J.; Milovich, J.; Callahan, D.

    2012-10-01

    HDC ablators show high performance based on simulations, despite the fact that the shorter pulses for HDC capsules result in higher M-band radiation compared to that for plastic capsules. HDC capsules have good 1-D performance because HDC has relatively high density (3.5 g/cc), which results in a thinner ablator that absorbs more radiation. HDC ablators have good 2-D performance because the ablator surface is more than an order-of-magnitude smoother than Be or plastic ablators. Refreeze of the ablator near the fuel region can be avoided by appropriate dopant placement. Here we present two HDC ignition designs doped with W and Si. For the design with maximum W concentration of 1.0 at% (and respectively with maximum Si concentration of 2.0 at%): peak velocity = 0.395 (0.397) mm/ns, mass weighted fuel entropy = 0.463 (0.469) kJ/mg/eV, peak core hydrodynamic stagnation pressure = 690 (780) Gbar, and yield = 17.3 (20.2) MJ. 2-D simulations show that yield is close to 80% YoC even with 2.5x of nominal surface roughness on all surfaces. The clean fuel fraction is about 75% at peak velocity. Doping HDC with the required concentration of W and Si is in progress. A first undoped HDC Symcap is scheduled to be fielded later this year.

  15. NIC atomic operation unit with caching and bandwidth mitigation

    DOEpatents

    Hemmert, Karl Scott; Underwood, Keith D.; Levenhagen, Michael J.

    2016-03-01

    A network interface controller atomic operation unit and a network interface control method comprising, in an atomic operation unit of a network interface controller, using a write-through cache and employing a rate-limiting functional unit.

  16. National Ignition Campaign (NIC) Precision Tuning Series Shock Timing Experiments

    SciTech Connect

    Robey, H F; Celliers, P M

    2011-07-19

    A series of precision shock timing experiments have been performed on NIF. These experiments continue to adjust the laser pulse shape and employ the adjusted cone fraction (CF) in the picket (1st 2 ns of the laser pulse) as determined from the re-emit experiment series. The NIF ignition laser pulse is precisely shaped and consists of a series of four impulses, which drive a corresponding series of shock waves of increasing strength to accelerate and compress the capsule ablator and fuel layer. To optimize the implosion, they tune not only the strength (or power) but also, to sub-nanosecond accuracy, the timing of the shock waves. In a well-tuned implosion, the shock waves work together to compress and heat the fuel. For the shock timing experiments, a re-entrant cone is inserted through both the hohlraum wall and the capsule ablator allowing a direct optical view of the propagating shocks in the capsule interior using the VISAR (Velocity Interferometer System for Any Reflector) diagnostic from outside the hohlraum. To emulate the DT ice of an ignition capsule, the inside of the cone and the capsule are filled with liquid deuterium.

  17. Post-Shot Simulations of NIC Experiments with Comparison to X-ray Measurements

    NASA Astrophysics Data System (ADS)

    Eder, David; Jones, Oggie; Suter, Larry; Moore, Alastair; Schneider, Marilyn

    2012-10-01

    National Ignition Campaign experiments at NIF are ongoing and post-shot simulations play an important role in understanding the physical processes occurring in the quest for demonstrating fusion burn. In particular, it is important to understand the x-ray environment inside the hohlraum targets, which is studied using various x-ray diagnostics. The Dante instrument measures the time dependent x-ray emission escaping out of the hohlraum laser entrance holes (LEHs) and the SXI instrument provides a time-integrated image of both soft and hard x-rays. We compare calculated total x-ray emission with Dante data as well as the relative high energy Mband emission that contributes to capsule preheat. We correct our calculated x-ray emission to account for differences between simulation and data on LEH closure using SXI data. We provide results for both ``standard candle'' simulation with no added multipliers and for simulations with time-dependent multipliers that are used to obtain agreement with shock timing and implosion velocity data. The physics justification for the use of multipliers is to account for potential missing energy or incorrect ablation modeling. The relative importance of these two effects can be studied through comparison of post-shot simulations with x-ray measurements.

  18. Alfvénic oscillations of the electron distribution function: Linear theory and experimental measurements

    NASA Astrophysics Data System (ADS)

    Schroeder, J. W. R.; Skiff, F.; Howes, G. G.; Kletzing, C. A.; Carter, T. A.; Dorfman, S.

    2015-12-01

    Wave propagation can be an accurate method for determining material properties. High frequency whistler mode waves (0.7 < ω/|Ωce| < 1) in an overdense plasma (ωpe > |Ωce|) are damped primarily by Doppler-shifted electron cyclotron resonance. A kinetic description of whistler mode propagation parallel to the background magnetic field shows that damping is proportional to the parallel electron distribution function. This property enables an experimental determination of the parallel electron distribution function using a measurement of whistler mode wave absorption. The whistler mode wave absorption diagnostic uses this technique on UCLA's Large Plasma Device (LaPD) to measure the distribution of high energy electrons (5 - 10vte) with 0.1% precision. The accuracy is limited by systematic effects that need to be considered carefully. Ongoing research uses this diagnostic to investigate the effect of inertial Alfvén waves on the electron distribution function. Results presented here verify experimentally the linear effects of inertial Alfvén waves on the reduced electron distribution function, a necessary step before nonlinear physics can be tested. Ongoing experiments with the whistler mode wave absorption diagnostic are making progress toward the first direct detection of electrons nonlinearly accelerated by inertial Alfvén waves, a process believed to play an important role in auroral generation.

  19. Remarks on the parallel propagation of small-amplitude dispersive Alfvénic waves

    NASA Astrophysics Data System (ADS)

    Champeaux, S.; Laveder, D.; Passot, T.; Sulem, P. L.

    The envelope formalism for the description of a small-amplitude parallel-propagating Alfvén wave train is tested against direct numerical simulations of the Hall-MHD equations in one space dimension where kinetic effects are neglected. It turns out that the magnetosonic-wave dynamics departs from the adiabatic approximation not only near the resonance between the speed of sound and the Alfvén wave group velocity, but also when the speed of sound lies between the group and phase velocities of the Alfvén wave. The modulational instability then does not anymore affect asymptotically large scales and strong nonlinear effects can develop even in the absence of the decay instability. When the Hall-MHD equations are considered in the long-wavelength limit, the weakly nonlinear dynamics is accurately reproduced by the derivative nonlinear Schrödinger equation on the expected time scale, provided no decay instabilities are present. The stronger nonlinear regime which develops at later time is captured by including the coupling to the nonlinear dynamics of the magnetosonic waves.

  20. Soft x-ray images of the Laser Entrance Hole of NIC Hohlraums (paper, HTPD2012)

    SciTech Connect

    Schneider, M B; Meezan, N B

    2012-04-30

    Hohlraums at the National Ignition Facility convert laser energy into a thermal x-radiation drive, which implodes the capsule, thus compressing the fuel. The x-radiation drive is measured with a low resolution, time-resolved x-ray spectrometer that views the hohlraum's laser entrance hole (LEH) at 37{sup o} to the hohlraum axis. This measurement has no spatial resolution. To convert this to the drive inside the hohlraum, the area and fraction of the measured x-radiation which comes from the region inside the hohlraum must be known. The size of the LEH is measured with the time integrated Static X-ray Imager (SXI) which view the LEH at 18{sup o} to the hohlraum axis. A soft x-ray image has been added to the SXI to measure the fraction of x-radiation inside the LEH's Clear Aperture in order to correct the measured radiation. A multilayer mirror plus filter selects an x-ray band centered at 870 eV, near the x-ray energy peak of a 300 eV blackbody. Results from this channel and corrections to the x-radiation drive are discussed.

  1. Methyl-phospho-nic acid, CH3PO(OH)2.

    PubMed

    Reuter, Hans; Reichelt, Martin

    2014-03-01

    The asymmetric unit of the title compound, CH5O3P, contains two independent mol-ecules with nearly identical bond lengths and angles. In the crystal, each of the mol-ecules acts as acceptor (P=O) and donor (P-OH) of four hydrogen bonds to three adjacent mol-ecules, resulting in the formation of two different bilayers (one for each mol-ecule) stacked perpendicular to the a axis in the crystal.

  2. A multi-port 10GbE PCIe NIC featuring UDP offload and GPUDirect capabilities.

    NASA Astrophysics Data System (ADS)

    Ammendola, Roberto; Biagioni, Andrea; Frezza, Ottorino; Lamanna, Gianluca; Lo Cicero, Francesca; Lonardo, Alessandro; Martinelli, Michele; Stanislao Paolucci, Pier; Pastorelli, Elena; Pontisso, Luca; Rossetti, Davide; Simula, Francesco; Sozzi, Marco; Tosoratto, Laura; Vicini, Piero

    2015-12-01

    NaNet-10 is a four-ports 10GbE PCIe Network Interface Card designed for low-latency real-time operations with GPU systems. To this purpose the design includes an UDP offload module, for fast and clock-cycle deterministic handling of the transport layer protocol, plus a GPUDirect P2P/RDMA engine for low-latency communication with NVIDIA Tesla GPU devices. A dedicated module (Multi-Stream) can optionally process input UDP streams before data is delivered through PCIe DMA to their destination devices, re-organizing data from different streams guaranteeing computational optimization. NaNet-10 is going to be integrated in the NA62 CERN experiment in order to assess the suitability of GPGPU systems as real-time triggers; results and lessons learned while performing this activity will be reported herein.

  3. [The electronic use of the NANDA-, NOC- and NIC- classifications and implications for nursing practice].

    PubMed

    Bernhart-Just, Alexandra; Hillewerth, Kathrin; Holzer-Pruss, Christina; Paprotny, Monika; Zimmermann Heinrich, Heidi

    2009-12-01

    The data model developed on behalf of the Nursing Service Commission of the Canton of Zurich (Pflegedienstkommission des Kantons Zürich) is based on the NANDA nursing diagnoses, the Nursing Outcome Classification, and the Nursing Intervention Classification (NNN Classifications). It also includes integrated functions for cost-centered accounting, service recording, and the Swiss Nursing Minimum Data Set. The data model uses the NNN classifications to map a possible form of the nursing process in the electronic patient health record, where the nurse can choose nursing diagnoses, outcomes, and interventions relevant to the patient situation. The nurses' choice is guided both by the different classifications and their linkages, and the use of specific text components pre-defined for each classification and accessible through the respective linkages. This article describes the developed data model and illustrates its clinical application in a specific patient's situation. Preparatory work required for the implementation of NNN classifications in practical nursing such as content filtering and the creation of linkages between the NNN classifications are described. Against the background of documentation of the nursing process based on the DAPEP(1) data model, possible changes and requirements are deduced. The article provides a contribution to the discussion of a change in documentation of the nursing process by implementing nursing classifications in electronic patient records.

  4. Nursing Clinical Documentation System Structured on NANDA-I, NOC, and NIC Classification Systems.

    PubMed

    Peres, Heloisa Helena C; de Almeida Lopes M da Cruz, Diná; Tellez, Michelle; de Cassia Gengo e Silva, Rita; dos S Diogo, Regina Celia; Ortiz, Diley Cardoso F; Ortiz, Dóris R

    2015-01-01

    Information is a key feature that health professionals need to exercise their profession with efficiency and quality. This study aims to present the experience of the usage of an electronic system for clinical documentation in nursing in a university hospital. It is a methodological research of technology production. The system was developed in four phases: Conception, Elaboration, Construction, and Transition, and was named Electronic Documentation System of the University of São Paulo Nursing Process (PROCEnf-USP™). The knowledge base of PROCEnf-USP™ was organized in hierarchy of domains and classes, according to NNN linkages.

  5. 10-100 Gbps Offload NIC for WAN, NLR, and Grid Computing

    NASA Technical Reports Server (NTRS)

    Awrach, James; Maccabe, Arthur

    2011-01-01

    An extremely fast offload engine system has been developed that operates at 60 Gigabits per second (Gbps), and has scalability to 100 Gbps full-duplex (f-d). This system is based on unique coding and architecture derived from splintered UDP (User Datagram Protocol) offload technology, resulting in unique FPGA (field programmable gate array) intellectual property core and firmware. This innovation improves the networking speed of supercomputer clusters by providing an ultra-fast network protocol processing offload from a CPU (central processing unit) by inserting an offload engine into a host backplane and network connections. This runs on protocol firmware.

  6. Earth's magnetosphere and outer radiation belt under sub-Alfvénic solar wind

    PubMed Central

    Lugaz, Noé; Farrugia, Charles J.; Huang, Chia-Lin; Winslow, Reka M.; Spence, Harlan E.; Schwadron, Nathan A.

    2016-01-01

    The interaction between Earth's magnetic field and the solar wind results in the formation of a collisionless bow shock 60,000–100,000 km upstream of our planet, as long as the solar wind fast magnetosonic Mach (hereafter Mach) number exceeds unity. Here, we present one of those extremely rare instances, when the solar wind Mach number reached steady values <1 for several hours on 17 January 2013. Simultaneous measurements by more than ten spacecraft in the near-Earth environment reveal the evanescence of the bow shock, the sunward motion of the magnetopause and the extremely rapid and intense loss of electrons in the outer radiation belt. This study allows us to directly observe the state of the inner magnetosphere, including the radiation belts during a type of solar wind-magnetosphere coupling which is unusual for planets in our solar system but may be common for close-in extrasolar planets. PMID:27694887

  7. Earth's magnetosphere and outer radiation belt under sub-Alfvénic solar wind

    NASA Astrophysics Data System (ADS)

    Lugaz, Noé; Farrugia, Charles J.; Huang, Chia-Lin; Winslow, Reka M.; Spence, Harlan E.; Schwadron, Nathan A.

    2016-10-01

    The interaction between Earth's magnetic field and the solar wind results in the formation of a collisionless bow shock 60,000-100,000 km upstream of our planet, as long as the solar wind fast magnetosonic Mach (hereafter Mach) number exceeds unity. Here, we present one of those extremely rare instances, when the solar wind Mach number reached steady values <1 for several hours on 17 January 2013. Simultaneous measurements by more than ten spacecraft in the near-Earth environment reveal the evanescence of the bow shock, the sunward motion of the magnetopause and the extremely rapid and intense loss of electrons in the outer radiation belt. This study allows us to directly observe the state of the inner magnetosphere, including the radiation belts during a type of solar wind-magnetosphere coupling which is unusual for planets in our solar system but may be common for close-in extrasolar planets.

  8. Anisotropy of imbalanced Alfvénic turbulence in fast solar wind.

    PubMed

    Wicks, R T; Horbury, T S; Chen, C H K; Schekochihin, A A

    2011-01-28

    We present the first measurement of the scale-dependent power anisotropy of Elsasser variables in imbalanced fast solar wind turbulence. The dominant Elsasser mode is isotropic at lower spacecraft frequencies but becomes increasingly anisotropic at higher frequencies. The subdominant mode is anisotropic throughout. There are two distinct subranges exhibiting different scalings within what is normally considered the inertial range. The low Alfvén ratio and the different scaling of the Elsasser modes suggests an interpretation of the observed discrepancy between the velocity and magnetic field scalings, the total energy is dominated by the latter. These results do not appear to be fully explained by any of the current theories of incompressible imbalanced MHD turbulence.

  9. Anisotropy of imbalanced Alfvénic turbulence in fast solar wind.

    PubMed

    Wicks, R T; Horbury, T S; Chen, C H K; Schekochihin, A A

    2011-01-28

    We present the first measurement of the scale-dependent power anisotropy of Elsasser variables in imbalanced fast solar wind turbulence. The dominant Elsasser mode is isotropic at lower spacecraft frequencies but becomes increasingly anisotropic at higher frequencies. The subdominant mode is anisotropic throughout. There are two distinct subranges exhibiting different scalings within what is normally considered the inertial range. The low Alfvén ratio and the different scaling of the Elsasser modes suggests an interpretation of the observed discrepancy between the velocity and magnetic field scalings, the total energy is dominated by the latter. These results do not appear to be fully explained by any of the current theories of incompressible imbalanced MHD turbulence. PMID:21405329

  10. 77 FR 39741 - Solicitation for a Cooperative Agreement-Curricula Review and Revision: NIC Trainer Development...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... in the following: Curriculum design and development; Adult learning theory; Current research in the... demonstrated knowledge of adult learning theory? Is there a demonstrated knowledge of the ITIP model of... train trainers in existing curricula. All curricula will follow the Instructional Theory into...

  11. Satellites Probing the Alfvénic Resonator Cavity Experiment : SPARC-E

    NASA Astrophysics Data System (ADS)

    Dearborn, M. E.; Balthazor, R. L.; McHarg, M. G.; Huffman, J. J.

    2009-12-01

    We discuss a space sensor network that has the objective of understanding and quantitatively understanding the role of low frequency plasma waves in driving ion outflow from the ionosphere to the magnetosphere in the coupled magnetosphere-ionosphere (MI) system. Recently, attention has fallen on the Ionospheric Alfvén Resonator (IAR). The IAR is a cavity-resonator with natural frequencies ~0.1 - 5 Hz in the upper atmosphere, formed with a lower boundary at the conducting E-region and an upper boundary at the Alfvén speed maxima at around 1 earth radius. This cavity resonator is believed to play an important part in the development of perpendicular density and field aligned current (FAC) scales, resonant coupling with electromagnetic ion cyclotron waves that provide loss mechanisms for energetic particles in the radiation belt, and ion and energy outflow feedback mechanisms into the ionosphere. However, the simultaneous multi-point in-situ observations inside the IAR cavity that are needed to categorize observationally how the waves and density structures evolve have never been made. Validation of IAR models at low altitude would benefit from satellite measurements in the topside ionosphere. At assumed F-region altitudes of 200-400 km, optimal data will be obtained if the (unambiguous) spatial and temporal resolution of measurements is better than the expected phenomenon scales; this would require simultaneous in-situ measurements separated by spatial scales from as small as 100 m up to on the order of a few km, at up to ~1 s cadence. Remote imaging techniques integrate over the ionosphere within volumes that have scale sizes of several tens of km, and are thus unsuitable for determining the smaller spatial scales that are proposed in this study. Sensors on a single satellite taking point measurements suffer from an inherent inability to distinguish spatial and temporal effects, which is a strong requirement for unambiguously studying waves. An absolute minimum of four satellites in an out-of-plane constellation is required to unambiguously resolve space and time effects in the ambient region. The proposed SPARC-E mission consists of plasma sensors measuring electron temperature and density placed on eight satellites in similar orbits between 300 and 800 km. Inter-satellite separations increase over the lifetime of the mission from a few cm to tens of km. The mission concept is to deploy ten wirelessly-linked, very small satellites to take distributed, in-situ measurements of ionospheric plasma density and temperature in the IAR cavity. A high-latitude circular orbit (>60 degree inclination, ~350-800 km altitude) allows sensor satellites to enter and exit the IAR cavity region of interest and thus acquire both baseline and disturbed measurements. The constellation will not be maintained, but rather be launched together and allowed to disperse naturally due to orbital perturbations. Orbit control is not required or desired, as the natural perturbations will serve to alter the separation and lower the altitude over time without adding the complexity and overhead of a propulsion subsystem. We will describe details of the overall mission concept to include the payload, spacecraft bus, and mission operations.

  12. Mitigation of Alfvénic activity by 3D magnetic perturbations on NSTX

    NASA Astrophysics Data System (ADS)

    Kramer, G. J.; Bortolon, A.; Ferraro, N. M.; Spong, D. A.; Crocker, N. A.; Darrow, D. S.; Fredrickson, E. D.; Kubota, S.; Park, J.-K.; Podestà, M.; Heidbrink, W. W.; the NSTX Team

    2016-08-01

    Observations on the National Spherical Torus Experiment (NSTX) indicate that externally applied non-axisymmetric magnetic perturbations (MP) can reduce the amplitude of toroidal Alfvén eigenmodes (TAE) and global Alfvén eigenmodes (GAE) in response to pulsed n  =  3 non-resonant fields. From full-orbit following Monte Carlo simulations with the one- and two-fluid resistive MHD plasma response to the magnetic perturbation included, it was found that in response to MP pulses the fast-ion losses increased and the fast-ion drive for the GAEs was reduced. The MP did not affect the fast-ion drive for the TAEs significantly but the Alfvén continuum at the plasma edge was found to be altered due to the toroidal symmetry breaking which leads to coupling of different toroidal harmonics. The TAE gap was reduced at the edge creating enhanced continuum damping of the global TAEs, which is consistent with the observations. The results suggest that optimized non-axisymmetric MP might be exploited to control and mitigate Alfvén instabilities by tailoring the fast-ion distribution function and/or continuum structure.

  13. Alfvénic oscillations of the electron distribution function: Linear theory and experimental measurements

    SciTech Connect

    Schroeder, J. W. R. Skiff, F.; Howes, G. G.; Kletzing, C. A.; Carter, T. A.; Dorfman, S.

    2015-12-10

    Wave propagation can be an accurate method for determining material properties. High frequency whistler mode waves (0.7 < ω/|Ω{sub ce}| < 1) in an overdense plasma (ω{sub pe} > |Ω{sub ce}|) are damped primarily by Doppler-shifted electron cyclotron resonance. A kinetic description of whistler mode propagation parallel to the background magnetic field shows that damping is proportional to the parallel electron distribution function. This property enables an experimental determination of the parallel electron distribution function using a measurement of whistler mode wave absorption. The whistler mode wave absorption diagnostic uses this technique on UCLA’s Large Plasma Device (LaPD) to measure the distribution of high energy electrons (5 − 10v{sub te}) with 0.1% precision. The accuracy is limited by systematic effects that need to be considered carefully. Ongoing research uses this diagnostic to investigate the effect of inertial Alfvén waves on the electron distribution function. Results presented here verify experimentally the linear effects of inertial Alfvén waves on the reduced electron distribution function, a necessary step before nonlinear physics can be tested. Ongoing experiments with the whistler mode wave absorption diagnostic are making progress toward the first direct detection of electrons nonlinearly accelerated by inertial Alfvén waves, a process believed to play an important role in auroral generation.

  14. An Anisotropic-Alfvénic-turbulence-based Solar Wind Model with Proton Temperature Anisotropy

    NASA Astrophysics Data System (ADS)

    Li, B.; Habbal, S. R.

    2013-04-01

    How the solar wind is accelerated to its supersonic speed is intimately related to how it is heated. Mechanisms based on ion-cyclotron resonance have been successful in explaining a large number of observations, those concerning the significant ion temperature anisotropy above coronal holes in particular. However, they suffer from the inconsistency with turbulence theory which says that the turbulent cascade in a low-beta medium like the solar corona should proceed in the perpendicular rather than the parallel direction, meaning that there is little energy in the ion gyro-frequency range for ions to absorb via ion-cyclotron resonance. Recently a mechanism based on the interaction between the solar wind particles and the anisotropic turbulence has been proposed, where the perpendicular proton energy addition is via the stochastic heating (Chandran et al. 2011). We extend this promising mechanism by properly accounting for the effect of proton temperature anisotropy on the propagation of Alfvén waves, for the radiative losses of electron energy, and for the field line curvature that naturally accompanies solar winds in the corona. While this mechanism was shown in previous studies to apply to the polar fast solar wind, we demonstrate here for the first time that it applies also to the slow wind flowing along field lines bordering streamer helmets.

  15. Distinguishing Between Quasi-static and Alfvénic Auroral Acceleration Processes

    NASA Astrophysics Data System (ADS)

    Lysak, R. L.; Song, Y.

    2013-12-01

    Models for the acceleration of auroral particles fall into two general classes. Quasi-static processes, such as double layers or magnetic mirror supported potential drops, produce a nearly monoenergetic beam of precipitating electrons and upward flowing ion beams. Time-dependent acceleration processes, often associated with kinetic Alfvén waves, can produce a broader range of energies and often have a strongly field-aligned pitch angle distribution. Both processes are associated with strong perpendicular electric fields as well as the parallel electric fields that are largely responsible for the particle acceleration. These electric fields and the related magnetic perturbations can be characterized by the ratio of the electric field to a perpendicular magnetic perturbation, which is related to the Pedersen conductivity in the static case and the Alfvén velocity in the time-dependent case. However, these considerations can be complicated by the interaction between upward and downward propagating waves. The relevant time and space scales of these processes will be assessed and the consequences for observation by orbiting spacecraft and ground-based instrumentation will be determined. These features will be illustrated by numerical simulations of the magnetosphere-ionosphere coupling with emphasis on what a virtual spacecraft passing through the simulation would be expected to observe.

  16. Materials Data on Ni(C2N3)2 (SG:58) by Materials Project

    DOE Data Explorer

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  17. Nonlinear energetic particle transport in the presence of multiple Alfvénic waves in ITER

    NASA Astrophysics Data System (ADS)

    Schneller, M.; Lauber, Ph; Briguglio, S.

    2016-01-01

    This work presents the results of a multi-mode iter study on toroidal Alfvén eigenmodes (TAEs), using the nonlinear hybrid Hagis-Ligka model. It is found that main conclusions from earlier studies of Asdex Upgrade discharges can be transferred to the iter scenario: global, nonlinear effects are crucial for the evolution of the multi-mode scenario. This work focuses on the iter 15 MA baseline scenario with a safety factor at the magnetic axis of q 0  =  0.986. The least damped eigenmodes of the system are identified with the gyrokinetic, non-perturbative Ligka solver, concerning the mode structure, frequency and damping. Taking into account all weakly damped modes that can be identified linearly, nonlinear simulations with Hagis reveal strong multi-mode behaviour: while in some parameter ranges, quasilinear estimates turn out to be reasonable approximations for the nonlinearly relaxed energetic particle (EP) profile, under certain conditions low-n TAE branches can be excited. As a consequence, not only grow amplitudes of all modes to (up to orders of magnitude) higher values compared to the single mode cases but also, strong redistribution is triggered in the outer radial area between \\sqrt{{{{\\hatρ}}\\text{pol}}}=0.6 and 0.85, far above quasilinear estimates.

  18. Alfv?nic Instabilities and Fast Ion Transport in the DIII-D Tokamak

    SciTech Connect

    Van Zeeland, M; Heidbrink, W; Nazikian, R; Austin, M; Berk, H; Gorelenkov, N; Holcomb, C; Kramer, G; Lohr, J; Luo, Y; Makowski, M; McKee, G; Petty, C; Prater, R; Solomon, W; White, R

    2008-10-14

    Neutral beam injection into reversed magnetic shear DIII-D plasmas produces a variety of Alfvenic activity including Toroidicity and Ellipticity induced Alfven Eigenmodes (TAE/EAE, respectively) and Reversed Shear Alfven Eigenmodes (RSAE) as well as their spatial coupling. These modes are typically studied during the discharge current ramp phase when incomplete current penetration results in a high central safety factor and strong drive due to multiple higher order resonances. During this same time period Fast-Ion D{sub {alpha}} (FIDA) spectroscopy shows that the central fast ion profile is flattened, the degree of which depends on the Alfven eigenmode amplitude. Interestingly, localized electron cyclotron heating (ECH) near the mode location stabilizes RSAE activity and results in significantly improved fast ion confinement relative to discharges with ECH deposition on axis. In these discharges, RSAE activity is suppressed when ECH is deposited near the radius of the shear reversal point and enhanced with deposition near the axis. To simulate the observed neutral beam ion redistribution, NOVA calculations of the 3D eigenmode structures are matched with experimental measurements and used in combination with the ORBIT guiding center following code. For fixed frequency eigenmodes, it is found that ORBIT calculations cannot explain the observed beam ion transport with experimentally measured mode amplitudes. Possible explanations are considered including recent simulation results incorporating eigenmodes with time dependent frequencies.

  19. Prueba de Ciencia Primer Grado (Science Test for the First Grade). [In Spanish

    ERIC Educational Resources Information Center

    Puerto Rico State Dept. of Education, Hato Rey.

    This document consists of three parts: (1) a manual for administering the science test to first graders (in Spanish), (2) a copy of the test itself (pictorial), and (3) a list of expected competencies in science for the first three grades (in English). The test consists of 25, four-choice items. For each item, the administrator reads a statement…

  20. Geografia de America Latina. Grados Seis-Diez (Geography of Latin America. Grades Six-Ten).

    ERIC Educational Resources Information Center

    Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

    This publication, intended for Spanish-speaking students in grades 6-10, has three main objectives. First, it serves as an introduction (or refresher) to basic geographic concepts. Second, it is an examination of the physical and political geography of Latin America. Third, it is designed to help students examine maps in a critical manner. The…

  1. Ninos del Arco Iris: Primar Grado = Children of the Rainbow: First Grade.

    ERIC Educational Resources Information Center

    New York City Board of Education, NY.

    This manual for first grade teachers provides suggestions and teaching materials that reflect the multicultural composition of New York City's (New York) public schools. It is organized into two sections: the first is in English, and the second is in Spanish. The English section contains the following six sections: (1) "Planning for the First…

  2. Implementation of Improvements in an Electronic Documentation Nursing Process System Structured on NANDA-I, NOC and NIC (NNN) Classification.

    PubMed

    Peres, Heloísa; Cruz, Diná; Tellez, Michelle; de Cássia Gengo E Silva, Rita; Ortiz, Diley; Diogo, Regina; Ortiz, Dóris R

    2016-01-01

    The aim of this study was to present the experience of a teaching hospital with the implementation of improvements to an electronic documentation system of the nursing process (PROCEnf-USP®). The improvements were based on functional performance and technical quality of the system. It was adopted Scrum method for version control PROCEnf-USP® by enabling agility, flexibility and possibility of integration between development and users. The PROCEnf-USP® has been used since 2009 and has professional and academic environments. The current version lets you generate reports and supports decisions about diagnoses, outcomes and interventions. It is provided the use of indicators to monitor results and registration at the point of care. The establishment of important.

  3. NANDA Diagnoses, NIC Interventions, and NOC Outcomes Used in an Electronic Health Record with Elementary School Children

    ERIC Educational Resources Information Center

    Lunney, Margaret

    2006-01-01

    This is a report of a secondary analysis of data from a published quasi-experimental feasibility study of the effects of implementing diagnoses from North American Nursing Diagnosis Association International, interventions from the Nursing Interventions Classification, and outcomes from the Nursing Outcomes Classification (referred to as NNN) on…

  4. MALDI-TOFMS analysis of coordination and organometallic complexes: a nic(h)e area to work in.

    PubMed

    Wyatt, Mark F

    2011-07-01

    A mini-review of the characterisation of metal-containing compounds by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOFMS) is presented. Organometallic and coordination compounds have many varied applications, most notably in industrial catalytic processes and also in the electronics and healthcare sectors. In general, the compounds discussed, be they small or large molecules, have a high percentage metal content, rather than simply containing 'a metal atom'. A brief history of the field is given, but the main scope over the last 5 years is covered in some detail. How MALDI-TOFMS compliments electrospray for metal-containing compounds is highlighted. Perspectives on recent advances, such as solvent-free and air/moisture-sensitive sample preparation, and potential future challenges and developments, such as nanomaterials and metallodrug/metallometabolite imaging, are given.

  5. Induced core formation time in subcritical magnetic clouds by large-scale trans-Alfvénic flows

    SciTech Connect

    Kudoh, Takahiro; Basu, Shantanu E-mail: basu@uwo.ca

    2014-10-20

    We clarify the mechanism of accelerated core formation by large-scale nonlinear flows in subcritical magnetic clouds by finding a semi-analytical formula for the core formation time and describing the physical processes that lead to them. Recent numerical simulations show that nonlinear flows induce rapid ambipolar diffusion that leads to localized supercritical regions that can collapse. Here, we employ non-ideal magnetohydrodynamic simulations including ambipolar diffusion for gravitationally stratified sheets threaded by vertical magnetic fields. One of the horizontal dimensions is eliminated, resulting in a simpler two-dimensional simulation that can clarify the basic process of accelerated core formation. A parameter study of simulations shows that the core formation time is inversely proportional to the square of the flow speed when the flow speed is greater than the Alfvén speed. We find a semi-analytical formula that explains this numerical result. The formula also predicts that the core formation time is about three times shorter than that with no turbulence, when the turbulent speed is comparable to the Alfvén speed.

  6. On properties of compressional Alfvén eigenmode instability driven by superAlfvénic ions

    NASA Astrophysics Data System (ADS)

    Gorelenkov, N. N.; Cheng, C. Z.

    2002-10-01

    Properties of the instability of compressional Alfvén eigenmodes (CAEs) in tokamak plasmas are studied in the cold plasma approximation with an emphasis on the instability driven by the energetic minority ion cyclotron resonance heating (ICRH) ions. The goal of the paper is to address a long standing problem of CAE half proton cyclotron harmonic excitation observed in pure deuterium plasma basing on new observations from Joint European Torus. As an example we apply earlier developed theory (Gorelenkov N.N. and Cheng C.Z. 1995 Nucl. Fusion 35 1743) to compare two cases: ion cyclotron emission (ICE) driven by charged fusion products and ICRH minority-driven ICE (MICE) (Cottrell G.A. 2000 Phys. Rev. Lett. 84 2397) recently observed on JET. Particularly in MICE spectrum, only instabilities with even harmonics of deuterium cyclotron frequency at the low-field-side plasma edge were reported. Odd deuterium-cyclotron frequency harmonics of ICE spectrum with frequencies between the integer cyclotron harmonics of protons can be driven only via the Doppler shifted cyclotron wave particle resonance of CAEs with fusion products, but are shown to be damped due to the electron Landau damping in experiments on MICE. Excitation of odd harmonics of MICE with high-field-side heating is predicted. Dependence of the MICE instability on the electron temperature is studied and is shown to be strong. Low electron β is required to excite odd harmonics of MICE.

  7. Implementation of Improvements in an Electronic Documentation Nursing Process System Structured on NANDA-I, NOC and NIC (NNN) Classification.

    PubMed

    Peres, Heloísa; Cruz, Diná; Tellez, Michelle; de Cássia Gengo E Silva, Rita; Ortiz, Diley; Diogo, Regina; Ortiz, Dóris R

    2016-01-01

    The aim of this study was to present the experience of a teaching hospital with the implementation of improvements to an electronic documentation system of the nursing process (PROCEnf-USP®). The improvements were based on functional performance and technical quality of the system. It was adopted Scrum method for version control PROCEnf-USP® by enabling agility, flexibility and possibility of integration between development and users. The PROCEnf-USP® has been used since 2009 and has professional and academic environments. The current version lets you generate reports and supports decisions about diagnoses, outcomes and interventions. It is provided the use of indicators to monitor results and registration at the point of care. The establishment of important. PMID:27332494

  8. Mitigation of Alfvénic MHD Activity in the NSTX Tokamak by Externally Applied Perturbation Fields

    NASA Astrophysics Data System (ADS)

    Bortolon, Alessandro; Heidbrink, William W.; Kramer, Gerrit J.; Park, Jong-Kyu; Fredrickson, Eric D.; Lore, Jeremy D.; Podesta, Mario

    2013-10-01

    Observations from NSTX experiments demonstrate that externally applied 3D magnetic fields can be used to alter the dynamic of bursting and chirping Alfvén modes, driven by energetic beam ions. Pulses of static n = 3 fields (δB/B ~ 0.01 at the plasma edge) were applied during plasma discharges with persistent Global Alfvén Eigenmode activity (n = 7-8, 400-700 kHz). In response to the perturbations, the mode amplitude, the bursting period and the frequency sweep were reduced by a factor of 2-3. For modes of weaker bursting character, the magnetic perturbation induced a temporary transition to a saturated continuous mode. The ~5% drops of neutron emission rate during the pulses suggest perturbation of the fast ion population. Calculations of the perturbed fast-ion distribution function, made with the SPIRAL code, indicate that the 3D perturbation affects the orbits of fast ions that resonate with the bursting modes. The results represent an early demonstration of the possibility of controlling fast-ion instabilities by ``phase-space engineering'' of the fast-ion distribution function. Supported by DOE contracts No. DE-FG02-06ER54867, DE-AC02-09CH11466.

  9. Alfvénic Turbulence and Kinetic Instabilities in the Expanding Solar Wind: Two-Dimensional Hybrid Simulations

    NASA Astrophysics Data System (ADS)

    Matteini, L.; Hellinger, P.; Landi, S.; Franci, L.; Verdini, A.; Travnicek, P. M.

    2014-12-01

    Couplings between large and small scales in solar wind turbulence are further complicated by the expansion, which acts at all scales and directly influences the particle thermodynamics. We present 2-D hybrid simulations of kinetic turbulence, including the effects of radial expansion by means of the hybrid expanding model (HEB). We investigate properties of the cascade first in standard hybrid simulations and then we analyze the effects of a slow expansion on the turbulent spectrum (spectral break, residual energy, cross-helicity). Incoherent spectra of balanced and inbalanced counter-propagating Alfvén waves are taken as initial conditions and the dependence on the plasma beta and the amplitude of fluctuations is investigated. We focus on the properties of the ion parallel and perpendicular heating driven by the turbulence, and on how this is modulated by the expansion. Turbulence shapes the properties of the plasma, generating local temperature anisotropy in the distribution functions, however the associated perpendicular heating and parallel cooling are not strong enough to counteract the expansion-driven anisotropic cooling. As a consequence, the plasma is driven towards the fire hose instability threshold with increasing heliocentric distance, in agreement with solar wind observations. Once the plasma enters into the fire hose unstable region, electromagnetic fluctuations driven by the ion temperature anisotropy are generated on top of the background turbulence. Despite the configuration of our simulations - out-of-plane mean magnetic field - which allows for the growth of only a subset of fire hose fluctuations, these waves are able to locally scatter the protons and partially reduce their unstable temperature anisotropy. Our findings show that kinetic instabilities driven by anisotropic distributions, like fire hose, can play a role also in turbulent and inhomogeneous plasmas, and suggest that these mechanisms are at work in the solar wind expansion.

  10. A Stringent Limit on the Amplitude of Alfvénic Perturbations in High-beta Low-collisionality Plasmas

    NASA Astrophysics Data System (ADS)

    Squire, J.; Quataert, E.; Schekochihin, A. A.

    2016-10-01

    It is shown that low-collisionality plasmas cannot support linearly polarized shear-Alfvén fluctuations above a critical amplitude δ {B}\\perp /{B}0∼ {β }-1/2, where β is the ratio of thermal to magnetic pressure. Above this cutoff, a developing fluctuation will generate a pressure anisotropy that is sufficient to destabilize itself through the parallel firehose instability. This causes the wave frequency to approach zero, interrupting the fluctuation before any oscillation. The magnetic field lines rapidly relax into a sequence of angular zig-zag structures. Such a restrictive bound on shear-Alfvén-wave amplitudes has far-reaching implications for the physics of magnetized turbulence in the high-β conditions prevalent in many astrophysical plasmas, as well as for the solar wind at ∼1 au where β ≳ 1.

  11. 78 FR 35316 - Solicitation for a Cooperative Agreement-Employment Retention Inventory Validation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... cooperative agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting proposals from.... This project will be a collaborative venture with the NIC Community Services Division. NIC Opportunity... cooperative agreement include (1) review of documents directly related to NIC's Employment...

  12. Apparent Motion of the Sun, Shadows of Objects and Measurement of Time in the View of Seventh Grade Students of Middle School. (Breton Title: Movimento Aparente do Sol, Sombras dos Objetos e Medição do Tempo na Visão de Alunos do Sétimo Ano do Ensino Fundamental.) Movimiento Aparente del Sol, Sombras de los Objetos y Medición del Tiempo en la Visión de Estudiantes del Séptimo Grado del Ciclo Pirmario

    NASA Astrophysics Data System (ADS)

    Iria Machado, Daniel

    2013-07-01

    analemático, conduzida por um monitor. Uma proporção significativa de estudantes desconhecia inicialmente a maioria dos fenômenos tratados. A intervenção realizada colaborou para uma parte dos alunos assimilar novos conceitos, propiciando o contato com novos fenômenos e, em menor grau, a elaboração de explicações a respeito destes, indicando um potencial educativo dessa ação. Porém, a contribuição para o entendimento de algumas das ideias exploradas foi pequena, apontando para a necessidade de se fazer observações, estudos e discussões complementares. El movimiento aparente del Sol en la esfera celeste y el comportamiento de las sombras de los objetos a lo largo del tiempo son fenómenos observables en la vida cotidiana. Sin embargo, los estudiantes a menudo no tienen una adecuada comprensión de dichos problemas, e incluso pueden mostrar conceptos erróneos acerca de ellos. Por lo tanto, se realizó una investigación a fin de conocer las nociones de los estudiantes acerca de estas cuestiones y evaluar la contribución a su comprensión proporcionada por una actividad realizada con un reloj de Sol interactivo, en un entorno informal de aprendizaje. Se investigaron las ideas de 43 estudiantes del séptimo grado del ciclo primario mediante la aplicación de un test con preguntas abiertas antes y después de una actividad con un reloj de Sol analemático, dirigida por un monitor. Una proporción significativa de los estudiantes inicialmente desconocía la mayoría de los fenómenos tratados. La intervención realizada contribuyó para que los estudiantes asimilasen nuevos conceptos, proporcionando el contacto con nuevos fenómenos y, en menor medida, desarrollasen explicaciones acerca de estos, lo que indica un potencial educativo de esta acción. Sin embargo, la contribución a la comprensión de algunas de las ideas exploradas fue pequeña, lo que apunta a la necesidad de hacer observaciones, estudios y debates adicionales.

  13. Prevenir y Combatir El Acoso en La Escuela: Guia de Recursoso para Educadores de los Grados "K" al Grado "12" (Preventing and Countering School-Based Harassment: A Resource Guide for K-12 Educators).

    ERIC Educational Resources Information Center

    Steineger, Melissa

    This guide focuses on the issue of school-based harassment. It is intended to help educators prevent or curtail all forms of harassment by highlighting school-based harassment issues, by describing remedies and prevention strategies, and by providing additional resources. It details some of the problems school-based harassment engenders, and it…

  14. Aprender haciendo; Manual del Maestro (1 and 6 Grados) (Learning as You Go Along: Teacher's Handbook) (First to Sixth Grades).

    ERIC Educational Resources Information Center

    Secretaria de Educacion Publica (Mexico).

    This document is an English-language abstract (approximately 1,500 words) of six teachers manuals from the first to the sixth grade as used in the Mexican school system. They include suggestions for exercises from folding, cutting out, pasting, coloring and similar operations designed for the first grade up to simple electrical and electronic…

  15. 78 FR 41088 - Solicitation for a Cooperative Agreement-Support Services for Community Services Division Networks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ...: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting... support services to NIC Community Services Division sponsored networks. The networks are designed for NIC... venture with the NIC Community Services Division. NIC Opportunity Number: 13CS19. This number...

  16. Hybrid simulation of shock formation for super-Alfvénic expansion of laser ablated debris through an ambient, magnetized plasma

    SciTech Connect

    Clark, S. E.; Schaeffer, D. B.; Everson, E. T.; Bondarenko, A. S.; Constantin, C. G.; Niemann, C.; Winske, D.

    2013-08-15

    Two-dimensional hybrid simulations of perpendicular collisionless shocks are modeled after potential laboratory conditions that are attainable in the LArge Plasma Device (LAPD) at the University of California, Los Angeles Basic Plasma Science Facility. The kJ class 1053 nm Nd:Glass Raptor laser will be used to ablate carbon targets in the LAPD with on-target energies of 100-500 J. The ablated debris ions will expand into ambient, partially ionized hydrogen or helium. A parameter study is performed via hybrid simulation to determine possible conditions that could lead to shock formation in future LAPD experiments. Simulation results are presented along with a comparison to an analytical coupling parameter.

  17. Jet-cooled laser-induced dispersed fluorescence spectroscopy of NiC: Observation of low-lying Ω = 0+ state

    NASA Astrophysics Data System (ADS)

    Mukund, Sheo; Yarlagadda, Suresh; Bhattacharyya, Soumen; Nakhate, S. G.

    2014-01-01

    Laser-induced dispersed fluorescence spectra of 58Ni12C molecules, produced in a free-jet apparatus, have been studied. A new low-lying Ω = 0+ state has been observed at Te = 5178 (6) cm-1. Based on previous ab initio calculations this state is plausibly assigned as 0+ spin-orbit component of the first excited Π state. The term energies of vibrational levels up to v = 10 for X1Σ+ ground and v = 3 for Ω = 0+ states have been determined. The harmonic and anharmonic wavenumbers respectively equal to 833 (4) and 6.7 (13) cm-1 for Ω = 0+ state have been measured.

  18. [THE EFFECTS OF CHRO- NIC ADMINISTRATION OF MODERATE DOSE OF PROINFLAMMATORY CYTOKINE INTERLEUKIN-1β ON RAT INVESTIGATIVE BEHAVIOR AND SPATIAL MEMORY].

    PubMed

    Kalemenev, S V; Sizov, V V; Ischenko, A M; Zubareva, O E

    2015-05-01

    The aim of this study was to discover the effects of chronic intraperitoneal administration of proinflammatory cytokine interleukin-1β (IL-1β) on rat investigative behavior and spatial memory. Rats were injected with a moderate pyrogenic dose of IL-1β (0.5 mkg/kg) daily during 14 days (7 days before tests and 7 testing days). The behavior was examined in 23.5 hours after the previous injection of cytokine. The test battery included: "The open field" (within 3 consecutive days), "The exploration of novel objects", and "The Morris water maze". The animals treated with IL-1β differed from the control animals in an essential decrease of locomotor activity, slight increase of anxiety and suppression of exploratory behavior. The impairment of spatial memory was not revealed.

  19. N,N',N'',N'''-Tetrakis(2-methylphenyl)-oxybis(phospho-nic diamide): a redetermination at 150 K with Mo Kα radiation.

    PubMed

    Pourayoubi, Mehrdad; Padělková, Zdeňka; Rostami Chaijan, Mahnaz; Růžička, Aleš

    2011-01-22

    The structure of the title compound, C(28)H(32)N(4)O(3)P(2), has been redetermined at 150 K, with much improved precision. The structure and mol-ecular packing of the title compound was previously determined using Cu Kα radiation, with an R value of 0.0933 [Cameron et al. (1978 ▶). Z. Naturforsch. Teil B, 33, 728-730]. The c-axis length in this structure [13.8401 (8) Å] is almost half that reported in the original study. In the title compound, two (C(6)H(4)(2-CH(3))NH)(2)P(O) units are bridged via an O atom [P-O-P = 133.31 (11)°]. The P atoms adopt a slightly distorted tetra-hedral coordination geometry. In the crystal, mol-ecules are linked via N-H⋯OP hydrogen bonds into extended chains parallel to the c axis. An intra-molecular N-H⋯O=P hydrogen bond is also found in the mol-ecule.

  20. Cyclo-hexyl-methyl-ammonium N,N'-dicyclo-hexyl-N,N'-dimethyl-N''-(2,2,2-trifluoro-acet-yl)phospho-nic triamide).

    PubMed

    Yazdanbakhsh, Mohammad; Eshtiagh-Hosseini, Hossein; Sabbaghi, Fahimeh

    2008-12-10

    In the salt, C(7)H(16)N(+)·C(16)H(28)F(3)N(3)O(2)P(-), the P atom shows tetra-hedral coordination. Two ion pairs are linked by N-H⋯O hydrogen bonds across a center of inversion. The phosphoryl and carbonyl groups are staggered [O-P-N-C = 64.8 (3)°].

  1. IAA-producing Penicillium sp. NICS01 triggers plant growth and suppresses Fusarium sp.-induced oxidative stress in sesame (Sesamum indicum L.).

    PubMed

    Radhakrishnan, Ramalingam; Shim, Kang-Bo; Lee, Byeong-Won; Hwang, Chung-Dong; Pae, Suk-Bok; Park, Chang-Hwan; Kim, Sung-Up; Lee, Choon-Ki; Baek, In-Youl

    2013-06-28

    Application of rhizospheric fungi is an effective and environmentally friendly method of improving plant growth and controlling many plant diseases. The current study was aimed to identify phytohormone-producing fungi from soil, to understand their roles in sesame plant growth, and to control Fusarium disease. Three predominant fungi (PNF1, PNF2, and PNF3) isolated from the rhizospheric soil of peanut plants were screened for their growth-promoting efficiency on sesame seedlings. Among these isolates, PNF2 significantly increased the shoot length and fresh weight of seedlings compared with controls. Analysis of the fungal culture filtrate showed a higher concentration of indole acetic acid in PNF2 than in the other isolates. PNF2 was identified as Penicillium sp. on the basis of phylogenetic analysis of ITS sequence similarity. The in vitro biocontrol activity of Penicillium sp. against Fusarium sp. was exhibited by a 49% inhibition of mycelial growth in a dual culture bioassay and by hyphal injuries as observed by scanning electron microscopy. In addition, greenhouse experiments revealed that Fusarium inhibited growth in sesame plants by damaging lipid membranes and reducing protein content. Co-cultivation with Penicillium sp. mitigated Fusarium-induced oxidative stress in sesame plants by limiting membrane lipid peroxidation, and by increasing the protein concentration, levels of antioxidants such as total polyphenols, and peroxidase and polyphenoloxidase activities. Thus, our findings suggest that Penicillium sp. is a potent plant growthpromoting fungus that has the ability to ameliorate damage caused by Fusarium infection in sesame cultivation.

  2. A high performance flexible all solid state supercapacitor based on the MnO2 sphere coated macro/mesoporous Ni/C electrode and ionic conducting electrolyte

    NASA Astrophysics Data System (ADS)

    Zhi, Jian; Reiser, Oliver; Wang, Youfu; Hu, Aiguo

    2016-06-01

    A high contact resistance between the active materials and the current collector, a low ionic conductivity of the gel electrolyte, and an impenetrable electrode structure are the three major barriers which greatly limit the capacitance of MnO2 in solid state supercapacitors. As a potential solution to these problems, in this work we report a novel electrode for solid state supercapacitors, based on a ternary system composed of hierarchical MnO2 spheres as the active material, macroporous Ni foam as gel penetrable skeletons and an ordered mesoporous carbon (OMC) membrane as the charge-transport accelerating layer. By employing butyl-3-methylimidazolium chloride (BMIMCl) modified gels as the ionic conducting electrolyte, the utilization efficiency of MnO2 on the specific capacitance was enhanced up to 88% of the theoretical value, delivering a volumetric capacitance of 81 F cm-3, which is the highest value among MnO2 based solid state supercapacitors. Moreover, such a flexible device exhibits exceptional volumetric energy and power density (6.6 Wh L-1 and 549 W L-1, based on the whole device volume) combined with a small capacity loss of 8.5% after 6000 cycles under twisting. These encouraging findings unambiguously overcome the energy bottleneck of MnO2 in solid state supercapacitors, and open up a new application of macro/mesoporous materials in flexible devices.A high contact resistance between the active materials and the current collector, a low ionic conductivity of the gel electrolyte, and an impenetrable electrode structure are the three major barriers which greatly limit the capacitance of MnO2 in solid state supercapacitors. As a potential solution to these problems, in this work we report a novel electrode for solid state supercapacitors, based on a ternary system composed of hierarchical MnO2 spheres as the active material, macroporous Ni foam as gel penetrable skeletons and an ordered mesoporous carbon (OMC) membrane as the charge-transport accelerating layer. By employing butyl-3-methylimidazolium chloride (BMIMCl) modified gels as the ionic conducting electrolyte, the utilization efficiency of MnO2 on the specific capacitance was enhanced up to 88% of the theoretical value, delivering a volumetric capacitance of 81 F cm-3, which is the highest value among MnO2 based solid state supercapacitors. Moreover, such a flexible device exhibits exceptional volumetric energy and power density (6.6 Wh L-1 and 549 W L-1, based on the whole device volume) combined with a small capacity loss of 8.5% after 6000 cycles under twisting. These encouraging findings unambiguously overcome the energy bottleneck of MnO2 in solid state supercapacitors, and open up a new application of macro/mesoporous materials in flexible devices. Electronic supplementary information (ESI) available. See DOI: 10.1039/c6nr02215d

  3. Ionospheric Production Variation in Super-Alfvénic Regime: From Lunar-type Sputtering to Titan-type Ionospheric Interaction.

    NASA Astrophysics Data System (ADS)

    Vernisse, Y.; Motschmann, U. M.; Glassmeier, K. H.

    2015-12-01

    Solar wind plasma interactions with planetary obstacles having fully developed ionospheres such as Titan, and weakly sputtered particles such as Earth's moon are topics of active research. We aim at extending our understanding of such types of interaction by looking at intermediate states between weakly sputtering planetary obstacle and ionosphere-rich obstacles. We present results from our hybrid model AIKEF of planetary obstacles, using a Chapman profile for the ionosphere, and characterize them using currents flowing around the interaction region. Among our results, we evaluate the ionospheric conductivity at each obstacle related to its ionospheric production, giving an estimation of the ion production that triggers a bow shock. We explore two cases of ionospheric species, hydrogen and oxygen, separately. Results show that an oxygen generated ionosphere requires less production to trigger a bow shock than a hydrogen-generated ionosphere, as well as differences in the pick-up process and the induced asymmetry of the interaction region. The final results are summarized into three-dimensional schematics representing qualitative changes when tweaking the production.

  4. Note on one-fluid modeling of low-frequency Alfvénic fluctuations in a solar wind plasma with multi-ion components

    SciTech Connect

    Nariyuki, Y.; Umeda, T.; Suzuki, T. K.; Hada, T.

    2015-12-15

    A simple point of view that non-zero Alfvén ratio (residual energy) appears as a consequence of one-fluid modeling of uni-directional Alfvén waves in a solar wind plasma is presented. Since relative speeds among ions are incorporated into the one-fluid model as a pressure anisotropy, the Alfvén ratio can be finite due to the decrease in the phase velocity. It is shown that a proton beam component typically found in the solar wind plasma can contribute to generating non-zero Alfvén ratio observed in the solar wind plasma. Local equilibrium velocity distribution functions of each ion component are also discussed by using maximum entropy principle.

  5. The role of Alfvénic turbulence in the acceleration of the fast solar wind: "linkage" science with Solar Orbiter

    NASA Astrophysics Data System (ADS)

    Dolla, Laurent; Rodriguez, Luciano; Zhukov, Andrei; Verdini, Andrea

    2016-07-01

    One of the key points of the Solar Orbiter mission will be the joint observations by remote sensing and in situ instruments: the remote sensing instruments will observe the sources of the solar wind that will later be measured in situ at the spacecraft (or at Solar Probe Plus). This is an opportunity to elucidate the role of MHD waves and turbulence in the acceleration of the fast solar wind. Using spectro-imagers (SPICE) or EUV imagers (EUI), various observables of the plasma can be measured remotely in coronal holes: electron temperature and density, element abundances, Doppler velocities and especially ion temperatures, non-thermal velocity and amplitude of MHD waves in solar features, the latter three being different manifestations of the MHD wave spectrum and its effects. We present some preliminary results on correlations of such remote sensing observables with in-situ measurement at 1 AU, as one may expect on the base of currently available observations (Hinode/EIS, SDO/AIA, and Wind).

  6. A high performance flexible all solid state supercapacitor based on the MnO2 sphere coated macro/mesoporous Ni/C electrode and ionic conducting electrolyte.

    PubMed

    Zhi, Jian; Reiser, Oliver; Wang, Youfu; Hu, Aiguo

    2016-06-01

    A high contact resistance between the active materials and the current collector, a low ionic conductivity of the gel electrolyte, and an impenetrable electrode structure are the three major barriers which greatly limit the capacitance of MnO2 in solid state supercapacitors. As a potential solution to these problems, in this work we report a novel electrode for solid state supercapacitors, based on a ternary system composed of hierarchical MnO2 spheres as the active material, macroporous Ni foam as gel penetrable skeletons and an ordered mesoporous carbon (OMC) membrane as the charge-transport accelerating layer. By employing butyl-3-methylimidazolium chloride (BMIMCl) modified gels as the ionic conducting electrolyte, the utilization efficiency of MnO2 on the specific capacitance was enhanced up to 88% of the theoretical value, delivering a volumetric capacitance of 81 F cm(-3), which is the highest value among MnO2 based solid state supercapacitors. Moreover, such a flexible device exhibits exceptional volumetric energy and power density (6.6 Wh L(-1) and 549 W L(-1), based on the whole device volume) combined with a small capacity loss of 8.5% after 6000 cycles under twisting. These encouraging findings unambiguously overcome the energy bottleneck of MnO2 in solid state supercapacitors, and open up a new application of macro/mesoporous materials in flexible devices. PMID:27241801

  7. 47 CFR 11.44 - EAS message priorities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Messages; second, State Messages; and third, National Information Center (NIC) Messages. (c) Key EAS... distribution of Presidential Messages. NIC messages received from national networks which are not broadcast...

  8. 75 FR 11561 - Solicitation for a Cooperative Agreement-Training for Executive Excellence: Leadership Style and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... Institute of Corrections' (NIC), Academy Division is seeking applications for the development of a...: Overview: NIC is looking to develop a curriculum, which follows NIC's Instructional Theory Into Practice... curriculum will be piloted, offered and changes made based upon NIC's evaluation protocol for the...

  9. 76 FR 1642 - Notice of Availability of Calendar Year 2011 Competitive Grant Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... (NIC; RFP Form- H) to participate in the competitive grants process. The deadline for filing the NIC is.... The dates shown in this notice for filing the NIC and the grant proposals supersede the dates in the... Applicants who may submit a NIC and a grant proposal to participate in the competitive grants process:...

  10. 76 FR 31363 - Solicitation for a Cooperative Agreement: Document-Tools in Assessing Inmates' Risks & Needs: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... Corrections (NIC) Jails Division is seeking applications for the development of a written guide on how to use... NIC Jails Division. The awardee will work closely with NIC staff on all aspects of the project. To be... management, as defined by NIC, and (4) ability to develop and write documents for publication....

  11. 78 FR 35319 - Solicitation for a Cooperative Agreement-Curriculum Development: Planning and Implementing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... National Institute of Corrections (NIC) is soliciting proposals from organizations, groups, or individuals... treatment. This project will be a collaborative venture with the NIC Jails Division. NIC Opportunity Number... in writing by NIC. Applications: All applicants must be submitted electronically via...

  12. 78 FR 40191 - Solicitation for a Cooperative Agreement-Development and Pilot Training of a Curriculum for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... Institute of Corrections (NIC) is soliciting proposals from organizations, groups, or individuals to enter... collaborative venture with the NIC Community Services Division. NIC Opportunity Number: 13CS04. This number... have a low probability of committing any criminal acts while in the community. NIC currently offers...

  13. 78 FR 35321 - Solicitation for a Cooperative Agreement-IBM Instructional Guide and Assessment Tool Development

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ...: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting... during their stay in jail. This project will be a collaborative venture with the NIC Jails Division. NIC... amended in writing by NIC. Applications: All applicants must be submitted electronically via...

  14. 75 FR 27581 - Solicitation for a Cooperative Agreement-Lesbian, Gay, Bisexual, Transgender, and Intersex...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... (NIC) is soliciting proposals from organizations, groups, or individuals to enter into a cooperative... CONTACT: A copy of this announcement can be downloaded from the NIC Web site at http://www.nicic.gov . All... description of NIC's role in the project, NIC review and approval points, and a project schedule. Note 1:...

  15. 76 FR 35013 - Notice of Inventory Completion; U.S. Department of the Interior, National Park Service, Fort...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... a Notice of Inventory Completion (NIC) previously published in the Federal Register (74 FR 24874... other site listed in the previous NIC. Therefore, the total number of individuals in the previous NIC will be changed from 11 to 16. Paragraph Number 4 in the NIC is Corrected by Substituting the...

  16. Las Matematicas: Lenguaje Universal. Grados Intermedios, Nivel 4a: Multiplicacion de Fracciones (Mathematics: A Universal Language. Intermediate Grades, Level 4a: Multiplication of Fractions).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in this booklet include equivalent fractions, mixed numbers, and multiplication of fractions and mixed numbers. (MK)

  17. Grados de comprobación de estudios de terapias integrales (PDQ®)—Versión para profesionales de salud

    Cancer.gov

    Información acerca de cómo sopesar la fuerza de los datos probatorios obtenidos de los estudios de investigación sobre terapias integrales, alternativas y complementarias en seres humanos con cáncer.

  18. Estudio muestra reducción de mortalidad en hombres con cáncer de próstata de grado intermedio

    Cancer.gov

    Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patroci

  19. Las Matematicas: Lenguaje Universal. Grados Intermedios, Niveles 4-6. Teacher's Guide II (Mathematics: A Universal Language. Intermediate Grades, Levels 4-6. Teacher's Guide II).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This guide covers the second part of a bilingual, sequential mathematics course. The course integrates culturally relevant situations and illustrations with mathematics to reinforce the student's self-concept and encourage cultural pride. This program may be used as a self-contained continuum, as a supplement to another course of study, for…

  20. Distribución espacial de órbitas con diferentes grados de caoticidad en modelos autoconsistentes de satélites galácticos

    NASA Astrophysics Data System (ADS)

    Muzzio, J. C.; Mosquera, M.

    En trabajos anteriores (Carpintero et al., Cel. Mech. Dynam. Astron. 85, 247, 2003), mostramos que las órbitas caóticas son muy importantes en los satélites galácticos. Sin embargo, los únicos modelos autoconsistentes de los que se disponía para ellos eran los de Heggie-Ramamani, cuya función de distribución depende sólo de la energía por lo que no mostraban diferencias entre las distribuciones de sus órbitas regulares y caóticas. Ahora, mediante una aproximación cuadrupolar, hemos logrado construir modelos autoconsistentes de satélites galácticos con distribuciones de velocidades anisotrópicas (lo que indica que sus funciones de distribución no dependen sólo de la energía) y hemos logrado revelar las diferencias entre las estructuras espaciales de las órbitas de distinta caoticidad.

  1. Las Matematicas: Lenguaje Universal. Grados Intermedios, Nivel 6b: Resta de Fracciones (Mathematics: A Universal Language. Intermediate Grades, Level 6b: Subtraction of Fractions).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in this booklet include subtraction of fractions and mixed numbers. (MK)

  2. Las Matematicas: Lenguaje Universal. Grados Intermedios, Nivel 5a: Geometria - Conjuntos de Puntos (Mathematics: A Universal Language. Intermediate Grades, Level 5a: Geometry - Sets of Points).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in the booklet include points, lines, planes, space, angles, and intersection and union of sets. (MK)

  3. Las Matematicas: Lenguaje Universal. Grados Intermedios, Nivel 5b: Medida Lineal, Perimetro y Area (Mathematics: A Universal Language. Intermediate Grades, Level 5b: Linear Measure, Perimeter and Area).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in this booklet include measurement, perimeter, and area. (MK)

  4. Las Matematicas: Lenguaje Universal. Grados Intermedios, Nivel 4b: Division de Fracciones (Mathematics: A Universal Language. Intermediate Grades, Level 4b: Division of Fractions).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in this booklet include reciprocals, complex fractions, and division of fractions. (MK)

  5. Las Matematicas: Lenguaje Universal. Grados Intermedios, Nivel 6a: Suma de Fracciones (Mathematics: A Universal Language. Intermediate Grades, Level 6a: Addition of Fractions).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This is one of a series of student booklets designed for use in a bilingual mathematics program in grades 6-8. The general format is to present each page in both Spanish and English. The mathematical topics in this booklet include addition of fractions and mixed numbers. (MK)

  6. Las Matematicas: Lenguaje Universal. Grados Intermedios, Niveles 1-3. Teacher's Guide I (Mathematics: A Universal Language. Intermediate Grades, Level 1-3. Teacher's Guide I).

    ERIC Educational Resources Information Center

    Dissemination and Assessment Center for Bilingual Education, Austin, TX.

    This guide covers the first part of a bilingual, sequential mathematics course. The course integrates culturally relevant situations and illustrations with mathematics to reinforce the student's self-concept and encourage cultural pride. This program may be used as a self-contained continuum, as a supplement to another course of study, for…

  7. Las normas de desempeno matematico desde el preescolar hasta el segundo grado (Mathematics Standards for Pre-Kindergarten through Grade 2). ERIC Digest.

    ERIC Educational Resources Information Center

    Richardson, Kathy

    The National Council of Teachers of Mathematics recently published "Principles and Standards for School Mathematics." For the first time, these new standards include pre-kindergarten standards, while outlining the mathematics that children should learn as they progress through school. The standards present a broad view of what mathematics is and…

  8. [Dietary supplements as a treatment for cervical cancer: a systematic review].

    PubMed

    Arellano Ortiz, Ana Lidia; Jiménez Vega, Florinda; Salcedo Vargas, Mauricio

    2013-11-01

    Introducción: En el cáncer cervicouterino (CaCu) y neoplasias intraepiteliales cervicales (NIC) se requiere de una cuidadosa selección de terapias convencionales y complementarias, la inclusión de suplementos dietéticos dentro de ellas marcaría la pauta dentro de los tratamientos. Sin embargo, no se tiene algún reporte de qué tipo de suplementos pudieran ser utilizados para brindar una mejor respuesta ante la enfermedad por estas pacientes. Objetivo: En la presente revisión se analizan los ensayos clínicos de los últimos 20 años que evaluaron suplementos dietéticos en esta población, con el objetivo de dar a conocer cuáles de ellos son viables para ser administrados. Metodología: Se realizó una búsqueda de ensayos clínicos que utilizaron algún suplemento dietario en mujeres con CaCu y algún grado de NIC analizando en ellos el modo de utilización del suplemento; el tratamiento convencional; si existe una deficiencia del nutriente ó compuesto a evaluar; las características de la población, del ensayo clínico y del suplemento; así como la dosis y los efectos esperados. Resultados: Veinte fueron en total el número de estudios analizados. Los artículos fueron clasificados según la naturaleza del suplemento: Retinoides, vitamina E, probióticos, indoles, multivitamínico, ácido fólico y selenio. Conclusión: Para el tratamiento de CaCu y NIC resultaron efectivos algunos de los suplementos encontrados en esta revisión, sin embargo su efecto dependerá de diferentes factores propios de la enfermedad. Debido a esto, es necesario el manejo correcto de los suplementos dietéticos para poder ser utilizados eficientemente como tratamiento complementario en esta población.

  9. Nicotine effects and the endogenous opioid system.

    PubMed

    Kishioka, Shiroh; Kiguchi, Norikazu; Kobayashi, Yuka; Saika, Fumihiro

    2014-01-01

    Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins, and dynorphins) in the supraspinal cord. Additionally, systemic NIC administration induces the release of methionine-enkephalin in the spinal dorsal horn. NIC has acute neurophysiological actions, including antinociceptive effects, and the ability to activate the hypothalamic-pituitary-adrenal (HPA) axis. The endogenous opioid system participates in NIC-induced antinociception, but not HPA axis activation. Moreover, NIC-induced antinociception is mediated by α4β2 and α7 nAChRs, while NIC-induced HPA axis activation is mediated by α4β2, not α7, suggesting that the effects of NIC on the endogenous opioid system are mediated by α7, not α4β2. NIC has substantial physical dependence liability. The opioid-receptor antagonist naloxone (NLX) elicits NIC withdrawal after repeated NIC administration, and NLX-induced NIC withdrawal is inhibited by concomitant administration of an opioid-receptor antagonist. NLX-induced NIC withdrawal is also inhibited by concomitant administration of an α7 antagonist, but not an α4β2 antagonist. Taken together, these findings suggest that NIC-induced antinociception and the development of physical dependence are mediated by the endogenous opioid system, via the α7 nAChR.

  10. Nicotine effects and the endogenous opioid system.

    PubMed

    Kishioka, Shiroh; Kiguchi, Norikazu; Kobayashi, Yuka; Saika, Fumihiro

    2014-01-01

    Nicotine (NIC) is an exogenous ligand of the nicotinic acetylcholine receptor (nAChR), and it influences various functions in the central nervous system. Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins, and dynorphins) in the supraspinal cord. Additionally, systemic NIC administration induces the release of methionine-enkephalin in the spinal dorsal horn. NIC has acute neurophysiological actions, including antinociceptive effects, and the ability to activate the hypothalamic-pituitary-adrenal (HPA) axis. The endogenous opioid system participates in NIC-induced antinociception, but not HPA axis activation. Moreover, NIC-induced antinociception is mediated by α4β2 and α7 nAChRs, while NIC-induced HPA axis activation is mediated by α4β2, not α7, suggesting that the effects of NIC on the endogenous opioid system are mediated by α7, not α4β2. NIC has substantial physical dependence liability. The opioid-receptor antagonist naloxone (NLX) elicits NIC withdrawal after repeated NIC administration, and NLX-induced NIC withdrawal is inhibited by concomitant administration of an opioid-receptor antagonist. NLX-induced NIC withdrawal is also inhibited by concomitant administration of an α7 antagonist, but not an α4β2 antagonist. Taken together, these findings suggest that NIC-induced antinociception and the development of physical dependence are mediated by the endogenous opioid system, via the α7 nAChR. PMID:24882143

  11. Co-Administration of Ethanol and Nicotine: The Enduring Alterations in the Rewarding Properties of Nicotine and Glutamate Activity within the Mesocorticolimbic System of Female Alcohol-Preferring (P) Rats

    PubMed Central

    Deehan, Gerald A.; Hauser, Sheketha R.; Waeiss, R. Aaron; Knight, Christopher P.; Toalston, Jamie E.; Truitt, William A.; McBride, William J.; Rodd, Zachary A.

    2016-01-01

    Rationale The co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that an individual will relapse to drug-use while attempting to maintain abstinence. There is limited research examining the consequences of long-term EtOH and NIC co-abuse. Objectives The current experiments determined the enduring effects of chronic EtOH, NIC, or EtOH + NIC intake on the reinforcing properties of NIC and glutamate (GLU) activity within the mesocorticolimbic (MCL) system. Methods Alcohol-preferring (P) rats self-administered EtOH, Sacc + NIC or EtOH + NIC combined for 10 weeks. The reinforcing properties of 0.1–3.0 uM NIC within the nucleus accumbens shell (AcbSh) were assessed following a 2–3 week drug-free period using intracranial self-administration (ICSA) procedures. The effects of EtOH, Sacc, Sacc + NIC or EtOH + NIC intake on extracellular levels and clearance of glutamate (GLU) in the medial prefrontal cortex (mPFC) were also determined. Results Binge intake of EtOH (96–100 mg%) and NIC (21–27 mg/ml) were attained. All groups of P rats self-infused 3.0 uM NIC directly into the AcbSh; whereas only animals in the EtOH + NIC co-abuse group self-infused the 0.3 and 1.0 uM NIC concentrations. Additionally, self-administration of EtOH + NIC, but not EtOH, Sacc or Sacc + NIC, resulted in enduring increases in basal extracellular GLU levels in the mPFC. Conclusions Overall, the co-abuse of EtOH + NIC produced enduring neuronal alterations within the MCL which enhanced the rewarding properties of NIC in the AcbSh and elevated extracellular GLU levels within the mPFC. PMID:26306917

  12. A randomised controlled trial to measure the effects and costs of a dental caries prevention regime for young children attending primary care dental services: the Northern Ireland Caries Prevention In Practice (NIC-PIP) trial.

    PubMed Central

    Tickle, Martin; O'Neill, Ciaran; Donaldson, Michael; Birch, Stephen; Noble, Solveig; Killough, Seamus; Murphy, Lynn; Greer, Margaret; Brodison, Julie; Verghis, Rejina; Worthington, Helen V

    2016-01-01

    BACKGROUND Dental caries is the most common disease of childhood. The NHS guidelines promote preventative care in dental practices, particularly for young children. However, the cost-effectiveness of this policy has not been established. OBJECTIVE To measure the effects and costs of a composite fluoride intervention designed to prevent caries in young children attending dental services. DESIGN The study was a two-arm, parallel-group, randomised controlled trial, with an allocation ratio of 1 : 1. Randomisation was by clinical trials unit, using randomised permuted blocks. Children/families were not blinded; however, outcome assessment was blinded to group assessment. SETTING The study took place in 22 NHS dental practices in Northern Ireland, UK. PARTICIPANTS The study participants were children aged 2-3 years, who were caries free at baseline. INTERVENTIONS The intervention was composite in nature, comprising a varnish containing 22,600 parts per million (p.p.m.) fluoride, a toothbrush and a 50-ml tube of toothpaste containing 1450 p.p.m. fluoride; plus standardised, evidence-based prevention advice provided at 6-monthly intervals over 3 years. The control group received the prevention advice alone. MAIN OUTCOME MEASURES The primary outcome measure was conversion from caries-free to caries-active states. Secondary outcome measures were the number of decayed, missing or filled tooth surfaces in primary dentition (dmfs) in caries-active children, the number of episodes of pain, the number of extracted teeth and the costs of care. Adverse reactions (ARs) were recorded. RESULTS A total of 1248 children (624 randomised to each group) were recruited and 1096 (549 in the intervention group and 547 in the control group) were included in the final analyses. A total of 87% of the intervention children and 85% of control children attended every 6-month visit (p = 0.77). In total, 187 (34%) children in the intervention group converted to caries active, compared with 213 (39%) in the control group [odds ratio (OR) 0.81, 95% confidence interval (CI) 0.64 to 1.04; p = 0.11]. The mean number of tooth surfaces affected by caries was 7.2 in the intervention group, compared with 9.6 in the control group (p = 0.007). There was no significant difference in the number of episodes of pain between groups (p = 0.81). However, 164 out of the total of 400 (41%) children who converted to caries active reported toothache, compared with 62 out of 696 (9%) caries-free children (OR 7.1 95% CI 5.1 to 9.9; p < 0.001). There was no statistically significant difference in the number of teeth extracted in caries-active children (p = 0.95). Ten children in the intervention group had ARs of a minor nature. The average direct dental care cost was £155.74 for the intervention group and £48.21 for the control group over 3 years (p < 0.05). The mean cost per carious surface avoided over the 3 years was estimated at £251.00. LIMITATIONS The usual limitations of a trial such as generalisability and understanding the underlying reasons for the outcomes apply. There is no mean willingness-to-pay threshold available to enable assessment of value for money. CONCLUSIONS A statistically significant effect could not be demonstrated for the primary outcome. Once caries develop, pain is likely. There was a statistically significant difference in dmfs in caries-active children in favour of the intervention. Although adequately powered, the effect size of the intervention was small and of questionable clinical and economic benefit. FUTURE WORK Future work should assess the caries prevention effects of interventions to reduce sugar consumption at the population and individual levels. Interventions designed to arrest the disease once it is established need to be developed and tested in practice. TRIAL REGISTRATION Current Controlled Trials ISRCTN36180119 and EudraCT 2009-010725-39. FUNDING This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 20, No. 71. See the NIHR Journals Library website for further project information. PMID:27685609

  13. Use of the semi-equilibrium dialysis method in studying the thermodynamics of solubilization of org nic compounds in surfactant micelles. system n-hexadecylpyridinium chloride-phenol-water

    SciTech Connect

    Smith, G,A.; Christian, S.D.; Scamehorn, J.F.; Tucker, E.E.

    1986-06-01

    The semi-equilibrium dialysis method has been used to infer solubilization equilibrium constants or, alternatively, activity coefficients of solutes solubilized into micelles of aqueous surfactant solutions. Methods are described for inferring the concentrationa of monomers of the organic solute and of the surfactant on both sides of the dialysis membrane, under conditions where the organic solute is in equilibrium with both the high-concentration (retentate) and low-concentration (permeate) solutions. By using a form of the Gibbs-Duhem equation, activity coefficients of both phenol (the solubilizate) and n-hexadecylpyridinium chloride (the surfactant) are obtained for aqueous solutions at 25 /sup 0/C throughout a wide range of relative compositions of surfactant and solubilizate within the micelle. The apparent solubilization constant, K = (solubilized phenol)/((monomeric phenol) (micellar surfactant)), is found to decrease significantly as the mole fraction of phenol in the micelle increases.

  14. The NSINIC on-line system

    NASA Technical Reports Server (NTRS)

    Lev, Brian

    1991-01-01

    The NSI NIC on-line system is described in the form of view graphs. The following subject areas are covered: NSI history; the ADFTO's other on-line services; the current system; and the next generation of NSI NIC.

  15. 77 FR 1512 - Solicitation for a Cooperative Agreement: Strategic Essentials for the Advancement of Women...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... Corrections (NIC) will be no later than July 1, 2012. The applicant will be expected to deliver the training between October, 2012 and June, 2013. The training program will be announced on NIC's Web site in...

  16. 76 FR 33366 - New Jail Planning Initiative; Review and Revision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... pages 29268-29271. ``Notice''--Two corrections have been made to this solicitation. First, NIC has..., NIC has deleted the following review criteria listed under Applicant Organization and Project...

  17. Alternative splicing of basic chitinase gene PR3b in the low-nicotine mutants of Nicotiana tabacum L. cv. Burley 21

    PubMed Central

    Ma, Haoran; Wang, Feng; Wang, Wenjing; Yin, Guoying; Zhang, Dingyu; Ding, Yongqiang; Timko, Michael P.; Zhang, Hongbo

    2016-01-01

    Two unlinked semi-dominant loci, A (NIC1) and B (NIC2), control nicotine and related alkaloid biosynthesis in Burley tobaccos. Mutations in either or both loci (nic1 and nic2) lead to low nicotine phenotypes with altered environmental stress responses. Here we show that the transcripts derived from the pathogenesis-related (PR) protein gene PR3b are alternatively spliced to a greater extent in the nic1 and nic2 mutants of Burley 21 tobacco and the nic1nic2 double mutant. The alternative splicing results in a deletion of 65 nucleotides and introduces a premature stop codon into the coding region of PR3b that leads to a significant reduction of PR3b specific chitinase activity. Assays of PR3b splicing in F2 individuals derived from crosses between nic1 and nic2 mutants and wild-type plants showed that the splicing phenotype is controlled by the NIC1 and NIC2 loci, even though NIC1 and NIC2 are unlinked loci. Moreover, the transcriptional analyses showed that the splicing patterns of PR3b in the low-nicotine mutants were differentially regulated by jasmonate (JA) and ethylene (ET). These data suggest that the NIC1 and NIC2 loci display differential roles in regulating the alternative splicing of PR3b in Burley 21. The findings in this study have provided valuable information for extending our understanding of the broader effects of the low-nicotine mutants of Burley 21 and the mechanism by which JA and ET signalling pathways post-transcriptionally regulate the activity of PR3b protein. PMID:27664270

  18. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all incoming and outgoing transactions that pass through the system. (1) Contents. The NICS Audit Log will... other identifying information about the prospective transferee and the NTN). (i) NICS Audit Log...

  19. 77 FR 39514 - Solicitation for a Cooperative Agreement: Women Offenders: Developing an Agencywide Approach

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is seeking.... This project will be completed in conjunction with the NIC Community Services Division and the awardee will work closely with NIC staff on all aspects of the project. To be considered, applicants...

  20. Reflective Learning in Practice.

    ERIC Educational Resources Information Center

    Brockbank, Anne, Ed.; McGill, Ian, Ed.; Beech, Nic, Ed.

    This book contains 22 papers on reflective learning in practice. The following papers are included: "Our Purpose" (Ann Brockbank, Ian McGill, Nic Beech); "The Nature and Context of Learning" (Ann Brockbank, Ian McGill, Nic Beech); "Reflective Learning and Organizations" (Ann Brockbank, Ian McGill, Nic Beech); "Reflective Learning in Practice" (Ann…

  1. Characterization of nicardipine hydrochloride-induced cell injury in human vascular endothelial cells.

    PubMed

    Ochi, Masanori; Kawai, Yoshiko; Tanaka, Yoshiyuki; Toyoda, Hiromu

    2015-02-01

    Nicardipine hydrochloride (NIC), a dihydropyridine calcium-channel blocking agent, has been widely used for the treatment of hypertension. Especially, nicardipine hydrochloride injection is used as first-line therapy for emergency treatment of abnormally high blood pressure. Although NIC has an attractive pharmacological profile, one of the dose-limiting factors of NIC is severe peripheral vascular injury after intravenous injection. The goal of this study was to better understand and thereby reduce NIC-mediated vascular injury. Here, we investigated the mechanism of NIC-induced vascular injury using human dermal microvascular endothelial cells (HMVECs). NIC decreased cell viability and increased percent of dead cells in a dose-dependent manner (10-30 μg/mL). Although cell membrane injury was not significant over 9 hr exposure, significant changes of cell morphology and increases in vacuoles in HMVECs were observed within 30 min of NIC exposure (30 μg/mL). Autophagosome labeling with monodansylcadaverine revealed increased autophagosomes in the NIC-treated cells, whereas caspase 3/7 activity was not increased in the NIC-treated cells (30 μg/mL). Additionally, NIC-induced reduction of cell viability was inhibited by 3-methyladenine, an inhibitor of autophagosome formation. These findings suggest that NIC causes severe peripheral venous irritation via induction of autophagic cell death and that inhibition of autophagy could contribute to the reduction of NIC-induced vascular injury.

  2. 77 FR 43864 - Solicitation for a Cooperative Agreement-Development of a 21st Century Corrections Learning...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... Corrections (NIC) is soliciting proposals from organizations, groups, or individuals to enter into a... the NIC Learning and Performance White Paper (to be completed October, 2012), and the knowledge... corrections learning work within the NIC Academy and the field of corrections. It will also provide a...

  3. 78 FR 41084 - Solicitation for a Cooperative Agreement-Video Production: Direct Supervision Jails

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... for a cooperative agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting..., graphics, and footage shot in jails. This project will be a collaborative venture with the NIC Jails Division. NIC Opportunity Number: 13JD05. This number should appear in the reference line in your...

  4. 78 FR 48721 - Advisory Board; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... meeting of the National Institute of Corrections (NIC) Advisory Board. At least one portion of the meeting will be closed to the public. Name of the Committee: NIC Advisory Board. General Function of the... development, and recommend guidance to assist NIC's efforts in the areas of training, technical...

  5. 76 FR 33365 - Solicitation for a Cooperative Agreement: Document-Tools for Implementing Inmate Behavior...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Institute of Corrections (NIC) Jails Division is seeking applications for the development of a written guide... management (IBM), as defined by NIC. This document will be written in the context of inmate behavior... period and will be carried out in conjunction with the NIC Jails Division. The awardee will work...

  6. 76 FR 45618 - Solicitation for a Cooperative Agreement-Two Hearings of the National Institute of Corrections...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... (NIC) is soliciting proposals from organizations, groups, or individuals to enter into a cooperative... agreement will involve organizing two hearings of ] the NIC Advisory Board. The hearings will assist the Board in providing directions to NIC and the corrections field on the subject of organizational...

  7. 77 FR 41804 - Solicitation for a Cooperative Agreement: Development of Materials Specific to Compassion Fatigue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ... National Institute of Corrections (NIC) is seeking applications from organizations, groups, or individuals to enter into a cooperative agreement with NIC for an 18-month period to develop a series of products... the required application forms can be downloaded from the NIC Web site at...

  8. 75 FR 41892 - Solicitation for a Cooperative Agreement: Guidebook for Building High Performance Correctional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    .... ACTION: Solicitation for Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is... eight-month period to begin in September 2010. Work under this agreement will continue NIC's High... High Performance Correctional Organizations (BHPCO) and other NIC projects. Intended outcome:...

  9. 78 FR 40190 - Solicitation for a Cooperative Agreement-Sexual Safety in Women's Institutions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting proposals from... collaborative venture with the NIC Community Services Division. NIC Opportunity Number: 13CS10. This number... directly related to the project as described herein unless otherwise amended in writing by...

  10. 40 CFR 63.1210 - What are the notification requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Notification of intent to comply (NIC). These procedures apply to sources that have not previously complied... complied with the NIC requirements of §§ 63.1210 and 63.1212(a), which were in effect prior to October 11... must include all of the following key activities and dates in your NIC: (A) The dates by which...

  11. 76 FR 44956 - Solicitation for a Cooperative Agreement; Correctional Health Care Executive Curriculum Development

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    .... ACTION: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC... Administrator and a Health Services Administrator. This project will be for an eighteen-month period. NIC... Express, UPS, or similar service to ensure delivery by the due date as mail at NIC is sometimes...

  12. 76 FR 44958 - Solicitation for a Cooperative Agreement-Quarterly Publication of a “Corrections Mental Health...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    .... ACTION: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is... copy of this announcement can be downloaded from the NIC web page at http://www.nicic.gov . All..., Corrections Health Manager, National Institute of Corrections (NIC) at Apollard@bop.gov ....

  13. 77 FR 39511 - Solicitation for a Cooperative Agreement: Development of a Guide for Correctional Agencies To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...: The National Institute of Corrections (NIC) is seeking applications from organizations, groups, or... the required application forms can be downloaded from the NIC Web site at http://www.nicic.gov...@bop.gov . In addition to the direct reply, all questions and responses will be posted on NIC's...

  14. 75 FR 21349 - Solicitation for a Cooperative Agreement-Evaluation of Technical Assistance for Evidence-Based...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... National Institute of Corrections (NIC) is soliciting proposals to enter into a cooperative agreement for a... to the required application forms can be downloaded from the NIC Web site at http://www.nicic.gov... document. ] Scope of Work: NIC will work with a technical assistance provider under Phase II of the...

  15. 75 FR 36695 - Solicitation for a Cooperative Agreement: Meetings of the Institutional Corrections Research...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-28

    .... SUMMARY: The National Institute of Corrections (NIC) is soliciting proposals from organizations, groups... corrections. NIC established ICRN in 2007 to promote the development of a stronger research infrastructure in... efforts sponsored by NIC that bring together corrections professionals from different sectors...

  16. 78 FR 41086 - Solicitation for a Cooperative Agreement-Children of Incarcerated Parents: Arrest Through Pre...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... (NIC) is soliciting proposals from organizations, groups, or individuals to enter into a cooperative... children of incarcerated parents. This project will be a collaborative venture with the NIC Community Services Division. NIC Opportunity Number: 13CS22. This number should appear in the reference line in...

  17. 75 FR 71148 - Solicitation for a Cooperative Agreement-Production of Seven Live Satellite/Internet Broadcasts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ...: Solicitation for a cooperative agreement. SUMMARY: The National Institute of Corrections (NIC) announces the... 5 minutes each) to support the content of the satellite/Internet broadcasts or to be used by NIC to... the NIC Web site at http://www.nicic.gov . All technical and/or programmatic questions concerning...

  18. 78 FR 35323 - Solicitation for a Cooperative Agreement-Gender-Informed Research (Women): Enhanced Approaches to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... (NIC) is seeking applications from organizations, groups, or individuals to enter into a cooperative agreement with NIC for an 18-month period to begin no later than September 15, 2013. Work under this... project that would further incorporate these keys areas into NIC initiatives and provide further...

  19. 77 FR 4363 - Solicitation for a Cooperative Agreement-Curriculum Development: Thinking for a Change 3.1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Corrections (NIC) Academy Division is seeking applications for the development of a competency-based, blended..., or by email at mguevara@bop.gov . SUPPLEMENTARY INFORMATION: Overview: NIC is looking to develop a blended curriculum that follows NIC's Instructional Theory into Practice (ITIP) model and is based on...

  20. 76 FR 68505 - Solicitation for a Cooperative Agreement-Production of Five Live Satellite/Internet Broadcasts

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ...: Solicitation for a cooperative agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting proposals from organizations, groups, or individuals to enter into a cooperative agreement with NIC for up... downloaded from the NIC Web site at http://www.nicic.gov . All technical and/or programmatic...

  1. 77 FR 40634 - Solicitation for a Cooperative Agreement: Pretrial Technical Assistance for Evidence-Based...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... National Institute of Corrections (NIC) Community Services Division is soliciting proposals from organizations, groups, or individuals to enter into a cooperative agreement with NIC for up to 12 months beginning in September 2012. Work under this cooperative agreement is part of a larger NIC...

  2. 76 FR 39438 - Solicitation for a Cooperative Agreement-Evaluating Early Access to Medicaid as a Reentry Strategy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    .... ACTION: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC... delivery by the due date as mail at NIC is sometimes delayed due to security screening. Hand-delivered... of this announcement and links to the required application forms can be downloaded from the NIC...

  3. 77 FR 43120 - Solicitation for a Cooperative Agreement-Dosage-Based Probation as an Effective Intervention

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ...: Solicitation for a Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) Community... cooperative agreement with NIC for up to 16 months beginning in October 2012. DATES: Application must be... announcement can be downloaded from the NIC Web site at www.nicic.gov/cooperativeagreements . All technical...

  4. 77 FR 44674 - Solicitation for a Cooperative Agreement-National Institute of Corrections Inaugural Virtual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... National Institute of Corrections (NIC) is soliciting proposals from organizations, companies, or agencies..., promotion, production, and delivery of an NIC Virtual Conference entitled ``Handcuff Key to Door Key: A... this announcement can be downloaded from the NIC Web site at www.nicic.gov . All technical...

  5. 75 FR 20863 - Solicitation for a Cooperative Agreement: Development of Two Documents-Inmate Behavior Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... announcement and links to the required application forms can be found on NIC's Web page at http://www.nicic.gov...: The National Institute of Corrections (NIC) has identified six key elements in the effective.... Purpose: The NIC Jails Division offers training and technical assistance on inmate behavior...

  6. 78 FR 43926 - Solicitation for a Cooperative Agreement-Evidence-Based Decision Making in State and Local...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ... Agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting proposals from organizations... August 15, 2013. Work under this cooperative agreement will be an extension of the NIC's Evidence-Based... planning for EBDM implementation. This project will be a collaborative venture with the NIC...

  7. 75 FR 39042 - Solicitation for a Cooperative Agreement: The Norval Morris Project Implementation Phase

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... for Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) is soliciting... period to begin in September 2010. Work under this agreement will continue NIC's Norval Morris Project by... extend the work of the Norval Morris Project and other NIC projects by assisting in the planning...

  8. 76 FR 50265 - Solicitation for a Cooperative Agreement-Management of Technical Assistance for Selected Sites in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... Assistance for Selected Sites in NIC's ``Evidence-Based Decision Making in Local Criminal Justice Systems... Cooperative Agreement. SUMMARY: The National Institute of Corrections (NIC) Community Services Division is... NIC for up to twelve months beginning in September 2011. Work under this cooperative agreement is...

  9. 75 FR 11562 - Solicitation for a Cooperative Agreement-Training for Executive Excellence: The Role of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... Corrections' (NIC), Academy Division is seeking applications for the development of a competency based... calling 303-365-4400, or by e-mail at rbrown@bop.gov . SUPPLEMENTARY INFORMATION: Overview: NIC is looking to develop a curriculum, which follows NIC's Instructional Theory Into Practice (ITIP) model....

  10. 75 FR 12802 - Notice of Availability of Calendar Year 2011 Competitive Grant Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ...) will be available April 8 2010. Applicants must file a Notice of Intent to Compete (NIC) to participate in the competitive grants process. Applicants must file the NIC by May 13 2010, 5 p.m. E.D.T. The due... governing boards are controlled by locally elected officials. The RFP, containing the NIC and...

  11. 77 FR 74876 - Agency Information Collection Activities; Existing Collection, Comments Requested; Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ...) Enrollment/National Instant Criminal Background Check System (NICS) E-Check Enrollment Form, Federal Firearms... Information Services (CJIS) Division's National Instant Criminal Background Check System (NICS) Section will... Acknowledgment of Responsibilities under the National Instant Criminal Background Check System (NICS) Form....

  12. Meal patterns in male rats during and after intermittent nicotine administration.

    PubMed

    Bellinger, Larry; Cepeda-Benito, Antonio; Wellman, Paul J

    2003-01-01

    Continuous administration of nicotine (NIC) reduces food intake (FI) and body weight (BW), whereas rebound eating and BW gain occur after NIC cessation. However, generalizations derived from prior studies on meal patterns in rats using continuous 24-h NIC administration are limited, because human smokers use NIC intermittently during their active period. In the present study, computerized meal pattern analyses (MPA) were conducted for adult male rats treated for 14 days with either saline or 2 or 4 mg/kg/day of NIC spread over five equal amounts during the dark phase. MPA analyses continued for 14 days after cessation of NIC. Only the 4 mg/kg/day NIC dose caused consistent changes in meal patterns and only that dose is reported herein. Dark period FI was reduced, whereas light period FI was unchanged in the NIC-treated group; thus, there was no rebound eating during the 12-h nontreatment phase. MPA analyses revealed the FI reduction on Day 1 of NIC administration was caused by a persistent decrease in dark phase meal size. On Day 5 of NIC, the rats compensated by significantly increasing the number of meals they took, which tended to normalize dark phase FI. Congruently, dark phase intermeal interval was decreased. Importantly, these changes in meal patterns persisted for 2 weeks after termination of NIC. Upon NIC cessation, the NIC group had a transient elevated FI. The NIC-treated group's BW was significantly suppressed by Day 6 of NIC and after stoppage these rats slowly, but incompletely, regained lost BW over the next 14 days. These results document that administration of NIC during the dark phase resulted in a reorganization of the microstructure of FI in male rats and that long-lasting alterations in the microstructure of FI (e.g., meal size and meal number) were noted for up to 2 weeks after cessation of NIC. These results differ from studies in which NIC was given continuously 24-h/day and indicate that dark phase NIC administration in rats may represent

  13. Mi Primer Libro de Maquinas Simples: Trabajo y Fuerza. Escuela Intermedia Grados 7, 8 y 9 (My First Book of Simple Machines: Work and Force. Intermediate School Grades 7, 8, and 9).

    ERIC Educational Resources Information Center

    Alvarado, Patricio R.; Montalvo, Luis

    This is the first book in a five-book physical science series on simple machines. The books are designed for Spanish-speaking junior high school students. This volume defines force and work by suggesting experiments and posing questions concerning drawings in the book which illustrate scientific principles. Answers to the questions are provided;…

  14. Matematicas Para La Escuela Primaria, Grado 4 (Parte 2), Comentario. Traduccion Preliminar de la Edicion en Ingles Revisada. (Mathematics for the Elementary School, Grade 4, Part 2, Teacher's Commentary. Preliminary Translation of the Revised English Edition).

    ERIC Educational Resources Information Center

    Beatty, Leslie; And Others

    This is Part 2 of the teacher's commentary for the grade 4 mathematics program. Part 2 includes the commentary for chapters 6 through 10. Topics covered include addition and subtraction, multiplication and division, geometrical figures, lines and lineal measurement, and fractions. (RH)

  15. Matematicas Para La Escuela Primaria, Grado 4 (Parte 1), Comentario. Traduccion Preliminar de la Edicion en Ingles Revisada. (Mathematics for the Elementary School, Grade 4, Part 1, Teacher's Commentary. Preliminary Translation of the Revised English Edition).

    ERIC Educational Resources Information Center

    Beatty, Leslie; And Others

    This is Part 1 of the teacher's commentary for the grade 4 mathematics program. Part 1 includes the commentary for chapters 1 through 5. Topics covered include congruence, numbers and number bases, subtraction of numbers, division of numbers, and elementary geometry. References to the student text are cited. (RH)

  16. The Role That Socioaffective Practices Play in Third Graders' Autonomous Learning (El papel de las prácticas socioafectivas en el aprendizaje autónomo de estudiantes de tercer grado)

    ERIC Educational Resources Information Center

    Perdomo Toro, Jhonatan; Rico González, Ángela Milena; Huepa Salcedo, Nury Catherine

    2011-01-01

    In this article we describe and analyze how autonomous learning emerges in third graders' socioaffective practices as reconstructed in written narratives. Results were obtained by analyzing and reflecting on classroom observation, interviews and written narratives done by the students which let us appreciate different behaviors and reactions…

  17. Supplement for Curriculum Guide for Mathematics: Spanish-Speaking Students, Grades 2-3 = Supplemento de la guia didactica de matematicas para los estudiantes de habla hispana, segundo y tercer grados. Field Test.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL.

    A contrastive analysis approach is used in this supplementary math curriculum guide for Spanish-speaking second and third grade students in Chicago public schools. Lessons are presented for those objectives for which the instructional strategies used in the United States differ from those used in Spanish-speaking countries. (Objectives for which…

  18. Supplement for Curriculum Guide for Mathematics: Spanish-Speaking Students, Grades 4-6 = Supplemento de la guia didactica de matematicas para los estudiantes de habla hispana, cuatro-sexto grados. Field Test.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL.

    This supplementary math curriculum guide for use with Spanish-speaking, fouth through sixth grade students in Chicago public schools employs a contrastive analysis approach. Lessons are presented for objectives for which the instructional strategies used in the United States differ from those used in Spanish-speaking countries. (Objectives for…

  19. Supplement for Curriculum Guide for Mathematics: Spanish-Speaking Students, Grades 7-8 = Supplemento de la guia didactica de matematicas para los estudiantes de habla hispana, septimo y octavo grados. Field Test.

    ERIC Educational Resources Information Center

    Chicago Board of Education, IL.

    This supplementary math curriculum guide for use with Spanish-speaking students in Chicago public schools' seventh and eighth grade classes employs a contrastive analysis approach. Lessons are presented for objectives for which the instructional strategies used in the United States differ from those in Spanish-speaking countries. (Objectives for…

  20. La Desercion Escolar en los Niveles de Sexto y Noveno Grado: Una Comparacion Entre Zonas Rurales y Urbanas. Boletin 219 (The Educational Desertion in the 6th and 9th Grades: A Comparison Between Rural and Urban Zones. Bulletin 219).

    ERIC Educational Resources Information Center

    Lopez, Maria I. Hernandez; And Others

    In 1962 and again in 1965, a group of sixth and ninth grade students in selected schools in four Puerto Rican communities were interviewed to investigate the factors influencing students' decision to withdraw from school before completing twelfth grade and to identify some characteristics of dropouts. Of 616 students interviewed in 1962, 20.9% of…

  1. Mi Quinto Libro de Maquinas Simples: El Plano Inclinado. Escuela Intermedia Grados 7, 8 y 9 (My Fifth Book of Simple Machines: The Inclined Plane. Intermediate School Grades 7, 8, and 9).

    ERIC Educational Resources Information Center

    Alvarado, Patricio R.; Montalvo, Luis

    This is the fifth book in a five-book physical science series on simple machines. The books are designed for Spanish-speaking junior high school students. This volume explains the principles and some of the uses of inclined planes, as they appear in simple machines, by suggesting experiments and posing questions concerning drawings in the book…

  2. Using Songs to Encourage Sixth Graders to Develop English Speaking Skills (Uso de canciones para motivar a los estudiantes de grado sexto a desarrollar habilidades orales en inglés)

    ERIC Educational Resources Information Center

    Duarte Romero, Mónica Duarte; Tinjacá Bernal, Luz Mery; Carrero Olivares, Marilú

    2012-01-01

    This article contains the procedures and findings of an investigation carried out by a team of teachers with the purpose of motivating students to speak English. We observed students' lack confidence to talk and that they had little motivation toward learning English. Thus, we used songs as a main resource in conjunction with different kind…

  3. Protective effect of N-acetylcysteine against nicardipine hydrochloride-induced autophagic cell death of human vascular endothelial cells.

    PubMed

    Ochi, Masanori; Tanaka, Yoshiyuki; Toyoda, Hiromu

    2015-01-01

    Nicardipine hydrochloride (NIC) injection has been widely used for emergency treatment of abnormally high blood pressure. However, NIC injection often causes severe peripheral vascular injury. The purpose of the present study was to reduce the NIC-induced cell injury in human vascular endothelial cells by use of clinical agents. The mechanism of NIC-induced cell injury was evaluated by time-lapse microscopic imaging, autophagosome staining with monodansylcadaverine, immunostaining of light chain 3 isoform B (LC-3B) and assessment of cell viability after exposure to NIC with or without an inhibitor of autophagosome formation (3-methyladenine, 3-MA). Results from autophagosome labeling and immunostaining of LC-3B revealed an increase of autophagosomes and LC-3B in NIC-treated cells. NIC-mediated reduction of cell viability was inhibited by 3-methyladenine. Moreover, we found that N-acetylcysteine (NAC) reduced NIC-induced cell injury in human vascular endothelial cells. These findings suggest that NIC causes severe peripheral venous irritation via induction of autophagic cell death and that inhibition of autophagy with NAC could contribute to the reduction of NIC-induced vascular injury.

  4. Nicorandil prevents sirolimus-induced production of reactive oxygen species, endothelial dysfunction, and thrombus formation.

    PubMed

    Aizawa, Ken; Takahari, Youko; Higashijima, Naoko; Serizawa, Kenichi; Yogo, Kenji; Ishizuka, Nobuhiko; Endo, Koichi; Fukuyama, Naoto; Hirano, Katsuya; Ishida, Hideyuki

    2015-03-01

    Sirolimus (SRL) is widely used to prevent restenosis after percutaneous coronary intervention. However, its beneficial effect is hampered by complications of thrombosis. Several studies imply that reactive oxygen species (ROS) play a critical role in endothelial dysfunction and thrombus formation. The present study investigated the protective effect of nicorandil (NIC), an anti-angina agent, on SRL-associated thrombosis. In human coronary artery endothelial cells (HCAECs), SRL stimulated ROS production, which was prevented by co-treatment with NIC. The preventive effect of NIC on ROS was abolished by 5-hydroxydecanoate but not by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. NIC also inhibited SRL-induced up-regulation of NADPH oxidase subunit p22(phox) mRNA. Co-treatment with NIC and SRL significantly up-regulated superoxide dismutase 2. NIC treatment significantly improved SRL-induced decrease in viability of HCAECs. The functional relevance of the preventive effects of NIC on SRL-induced ROS production and impairment of endothelial viability was investigated in a mouse model of thrombosis. Pretreatment with NIC inhibited the SRL-induced acceleration of FeCl3-initiated thrombus formation and ROS production in the testicular arteries of mice. In conclusion, NIC prevented SRL-induced thrombus formation, presumably due to the reduction of ROS and to endothelial protection. The therapeutic efficacy of NIC could represent an additional option in the prevention of SRL-related thrombosis.

  5. Co-crystallization with nicotinamide in two conformations lowers energy but expands volume.

    PubMed

    Zhang, Si-Wei; Kendrick, John; Leusen, Frank J J; Yu, Lian

    2014-09-01

    A dispersion-corrected density functional theory method has been used to study the formation energies and volumes of cocrystals. For four cocrystals of nicotinamide (NIC) and (R)-mandelic acid, a broad agreement is found between experimental and computed values. We report that cocrystals containing NIC are anomalous as their formation generally decreases energy but expands volume. In this respect, the formation of NIC cocrystals is in contrast to most physical processes, but similar to water freezing. As in the case of water freezing, the cocrystallization with NIC leads to stronger hydrogen bonds and looser molecular packing, a combination that is likely responsible for the anticorrelation between energy and volume. NIC has two conformers 4 kJ/mol apart in energy and both can form cocrystals, with the resulting structures having comparable formation energies and volumes. These results are relevant for understanding the nature of cocrystallization and why NIC is a prolific cocrystal former.

  6. The Sensory Impact of Nicotine on Noradrenergic and Dopaminergic Neurons of the Nicotine Reward - Addiction Neurocircuitry

    PubMed Central

    Rose, Jed E; Dehkordi, Ozra; Manaye, Kebreten F; Millis, Richard M; Cianaki, Salman Ameri; Jayam-Trouth, Annapurni

    2016-01-01

    The sensory experience of smoking is a key component of nicotine addiction known to result, in part, from stimulation of nicotinic acetylcholine receptors (nAChRs) at peripheral sensory nerve endings. Such stimulation of nAChRs is followed by activation of neurons at multiple sites in the mesocorticolimbic reward pathways. However, the neurochemical profiles of CNS cells that mediate the peripheral sensory impact of nicotine remain unknown. In the present study in mice, we first used c-Fos immunohistochemistry to identify CNS cells stimulated by nicotine (NIC, 40 μg/kg, IP) and by a peripherally-acting analog of nicotine, nicotine pyrrolidine methiodide (NIC-PM, 30 μg/kg, IP). Sequential double-labelling was then performed to determine whether noradrenergic and dopaminergic neurons of the nicotine reward-addiction circuitry were primary targets of NIC and NIC-PM. Double-labelling of NIC and/or NIC-PM activated c-Fos immunoreactive cells with tyrosine hydroxylase (TH) showed no apparent c-Fos expression by the dopaminergic cells of the ventral tegmental area (VTA). With the exception of sparse numbers of TH immunoreactive D11 cells, dopamine-containing neurons in other areas of the reward-addiction circuitry, namely periaqueductal gray, and dorsal raphe, were also devoid of c-Fos immunoreactivity. Noradrenergic neurons of locus coeruleus (LC), known to innervate VTA, were activated by both NIC and NIC-PM. These results demonstrate that noradrenergic neurons of LC are among the first structures that are stimulated by single acute IP injection of NIC and NIC-PM. Dopaminergic neurons of VTA and other CNS sites, did not respond to acute IP administration of NIC or NIC-PM by induction of c-Fos. PMID:27347434

  7. Ranolazine enhances nicardipine-induced relaxation of alpha1-adrenoceptor-mediated contraction on isolated rabbit aorta.

    PubMed

    Malavaki, Christina; Hatziefthimiou, Apostolia; Daskalopoulou, Stella S; Stefanidis, Ioannis; Karatzaferi, Christina; Aidonidis, Isaac

    2015-04-01

    Ranolazine (RAN) and nicardipine (NIC) have been studied for their vasorelaxing effects but the combination of these agents against adrenergic vasoconstriction has not been tested. The present study aimed at investigating the vasorelaxing effect by the combination of the two agents on alpha1-adrenoceptor-mediated contraction on isolated rabbit aorta. Aortic rings were mounted for isometric tension recording in organ baths containing Krebs-Henseleit solution. Concentration-response curves of RAN (10(-9) to 10(-4) M), NIC (10(-1) to 10(-5) M), and RAN + NIC (3 x 10(-6) M) were obtained in a cumulative manner using phenylephrine (PE, 2 x 10(-6) M) as constrictor agent. The effective concentration (EC)50 values for RAN and NIC were 6.5 x 10(-6) M and 1.4 x 10(-5) M, respectively. The treatment of PE-precontracted aortic rings with either RAN or NIC up to 65 min revealed that both agents displayed a biphasic pattern of initial rising and late sustained phases of relaxation. At 35 min of incubation, RAN and NIC induced relaxation by 23 +/- 3% and 14 +/- 4%, respectively (N = 7, P=NS, RAN vs. NIC); their combination resulted in a 34 +/- 4% relaxation (N=7; P < 0.01, RAN + NIC vs. NIC). At 65 min the effect of NIC prevailed and tended to be closer to the values of the combination treatment (P < 0.01, RAN + NIC vs. RAN). The results indicate that RAN at therapeutic concentrations exerts a significant additive vasorelaxing effect when combined with NIC in rabbit aorta.

  8. Baclofen prevented the changes in c-Fos and brain-derived neutrophic factor expressions during mecamylamine-precipitated nicotine withdrawal in mice.

    PubMed

    Varani, Andrés P; Moutinho Machado, Lirane; Balerio, Graciela N

    2014-11-01

    Previous studies from our laboratory showed that baclofen (BAC, GABAB receptor agonist) prevented the behavioral and neurochemical alterations of nicotine (NIC) withdrawal syndrome. To further investigate the mechanisms underlying these effects, we analyzed the c-Fos and brain-derived neutrophic factor (BDNF) expression during NIC withdrawal and its prevention with BAC. Swiss-Webster mice received NIC (2.5 mg/kg, sc) four times daily, for 7 days. On the 8th day, NIC-treated mice received the nicotinic antagonist mecamylamine (MEC; 2 mg/kg, i.p.) 1 h after the last dose of NIC. A second group of NIC-treated mice received BAC (2 mg/kg, i.p.) prior to MEC administration. Thirty minutes after MEC, mice were sacrificed and the immunohistochemistry assays (c-Fos and BDNF) were performed at different anatomical levels. c-Fos expression decreased in the dentate gyrus of the hippocampus (DG) and the bed nucleus of the stria terminalis (BST), and increased in the habenular (Hb), accumbens shell (AcbSh) nuclei during NIC withdrawal. BAC re-established the modified c-Fos expression only in the DG, BST and AcbSh during NIC withdrawal. Conversely, BDNF expression decreased in the CA1 and CA3 area of the hippocampus, the Hb, and caudate putamen (CPu) during NIC withdrawal. Finally, BAC restored the decreased BDNF expression during NIC withdrawal in the CA1, CA3, Hb, and CPu. The results suggest a relationship between BAC's preventive effect of the expression of NIC withdrawal signs, and its ability to restore the changes in c-Fos and BDNF expression, observed in specific brain areas of NIC-withdrawn mice.

  9. Ranolazine enhances nicardipine-induced relaxation of alpha1-adrenoceptor-mediated contraction on isolated rabbit aorta.

    PubMed

    Malavaki, Christina; Hatziefthimiou, Apostolia; Daskalopoulou, Stella S; Stefanidis, Ioannis; Karatzaferi, Christina; Aidonidis, Isaac

    2015-04-01

    Ranolazine (RAN) and nicardipine (NIC) have been studied for their vasorelaxing effects but the combination of these agents against adrenergic vasoconstriction has not been tested. The present study aimed at investigating the vasorelaxing effect by the combination of the two agents on alpha1-adrenoceptor-mediated contraction on isolated rabbit aorta. Aortic rings were mounted for isometric tension recording in organ baths containing Krebs-Henseleit solution. Concentration-response curves of RAN (10(-9) to 10(-4) M), NIC (10(-1) to 10(-5) M), and RAN + NIC (3 x 10(-6) M) were obtained in a cumulative manner using phenylephrine (PE, 2 x 10(-6) M) as constrictor agent. The effective concentration (EC)50 values for RAN and NIC were 6.5 x 10(-6) M and 1.4 x 10(-5) M, respectively. The treatment of PE-precontracted aortic rings with either RAN or NIC up to 65 min revealed that both agents displayed a biphasic pattern of initial rising and late sustained phases of relaxation. At 35 min of incubation, RAN and NIC induced relaxation by 23 +/- 3% and 14 +/- 4%, respectively (N = 7, P=NS, RAN vs. NIC); their combination resulted in a 34 +/- 4% relaxation (N=7; P < 0.01, RAN + NIC vs. NIC). At 65 min the effect of NIC prevailed and tended to be closer to the values of the combination treatment (P < 0.01, RAN + NIC vs. RAN). The results indicate that RAN at therapeutic concentrations exerts a significant additive vasorelaxing effect when combined with NIC in rabbit aorta. PMID:26148375

  10. Nursing to achieve organizational performance: Consider the role of nursing intellectual capital.

    PubMed

    Harris, Alexandra

    2016-05-01

    The success and performance of healthcare organizations relies on the strategic management of knowledge. Nursing Intellectual Capital (NIC) has emerged as a concept involving nursing knowledge resources that create value in healthcare organizations. This article aims to discuss the importance of considering knowledge resources in the context of healthcare performance, with specific reference to NIC. Reflections are then provided on how leaders can look to advance NIC for improved performance. PMID:27060807

  11. Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine.

    PubMed

    Ueno, Keiko; Kiguchi, Norikazu; Kobayashi, Yuka; Saika, Fumihiro; Wakida, Naoki; Yamamoto, Chizuko; Maeda, Takehiko; Ozaki, Masanobu; Kishioka, Shiroh

    2014-01-01

    We previously reported that nicotine (NIC)-induced analgesia was elicited in part by activation of the endogenous opioid system. Moreover, it is well known that NIC has physical-dependence liability, but its mechanism is unclear. Therefore, we examined whether physical dependence on NIC was mediated by activation of the endogenous opioid system in ICR mice. We evaluated increased serum corticosterone (SCS) as an indicator of NIC withdrawal, as it is a quantitative indicator of naloxone (opioid receptor antagonist, NLX)-precipitated morphine withdrawal in mice. In this study, NLX precipitated an SCS increase in mice receiving repeated NIC, by a dose-dependent mechanism, and correlated with the dose and number of days of repeated NIC administration. When an opioid receptor antagonist (naltrexone) was concomitantly administered with repeated NIC, the NLX-precipitated SCS increase was not elicited. Concomitant administration of the α7 nicotinic acetylcholine receptor (nAChR) antagonist (methyllycaconitine) with repeated NIC, but not the α4β2 nAChR antagonist (dihydro-β-erythroidine), did not elicit an SCS increase by NLX. Thus, a physical dependence on NIC was in part mediated by the activation of the endogenous opioid system, located downstream of α7 nAChR.

  12. An investigation of indomethacin-nicotinamide cocrystal formation induced by thermal stress in the solid or liquid state.

    PubMed

    Lin, Hong-Liang; Zhang, Gang-Chun; Huang, Yu-Ting; Lin, Shan-Yang

    2014-08-01

    The impact of thermal stress on indomethacin (IMC)-nicotinamide (NIC) cocrystal formation with or without neat cogrinding was investigated using differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) microspectroscopy, and simultaneous DSC-FTIR microspectroscopy in the solid or liquid state. Different evaporation methods for preparing IMC-NIC cocrystals were also compared. The results indicated that even after cogrinding for 40 min, the FTIR spectra for all IMC-NIC ground mixtures were superimposable on the FTIR spectra of IMC and NIC components, suggesting there was no cocrystal formation between IMC and NIC after cogrinding. However, these IMC-NIC ground mixtures appear to easily undergo cocrystal formation after the application of DSC determination. Under thermal stress induced by DSC, the amount of cocrystal formation increased with increasing cogrinding time. Moreover, simultaneous DSC-FTIR microspectroscopy was a useful one-step technique to induce and clarify the thermal-induced stepwise mechanism of IMC-NIC cocrystal formation from the ground mixture in real time. Different solvent evaporation rates induced by thermal stress significantly influenced IMC-NIC cocrystal formation in the liquid state. In particular, microwave heating may promote IMC-NIC cocrystal formation in a short time.

  13. Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression.

    PubMed

    Sari, Youssef; Toalston, Jamie E; Rao, P S S; Bell, Richard L

    2016-06-21

    Increased glutamatergic neurotransmission appears to mediate the reinforcing properties of drugs of abuse, including ethanol (EtOH). We have shown that administration of ceftriaxone (CEF), a β-lactam antibiotic, reduced EtOH intake and increased glutamate transporter 1 (GLT-1) expression in mesocorticolimbic regions of male and female alcohol-preferring (P) rats. In the present study, we tested whether CEF administration would reduce nicotine (NIC) and/or EtOH intake by adult female P rats. P rats were randomly assigned to 4 groups: (a) 5% sucrose (SUC) or 10% SUC [SUC], (b) 5% SUC+0.07mg/ml NIC and 10% SUC+0.14mg/ml NIC [NIC-SUC], 15% EtOH and 30% EtOH [EtOH] and (d) 15% EtOH+0.07mg/ml NIC and 30% EtOH+0.14mg/ml NIC [NIC-EtOH]. After achieving stable intakes (4weeks), the rats were administered 7 consecutive, daily i.p. injections of either saline or 200mg/kg CEF. The effects of CEF on intake were significant but differed across the reinforcers; such that ml/kg/day SUC was reduced by ∼30%, mg/kg/day NIC was reduced by ∼70% in the NIC-SUC group and ∼40% in the EtOH-NIC group, whereas g/kg/day EtOH was reduced by ∼40% in both the EtOH and EtOH-NIC group. The effects of CEF on GLT-1 expression were also studied. We found that CEF significantly increased GLT-1 expression in the prefrontal cortex and the nucleus accumbens of the NIC and NIC-EtOH rats as compared to NIC and NIC-EtOH saline-treated rats. These findings provide further support for GLT-1-associated mechanisms in EtOH and/or NIC abuse. The present results along with previous reports of CEF's efficacy in reducing cocaine self-administration in rats suggest that modulation of GLT-1 expression and/or activity is an important pharmacological target for treating polysubstance abuse and dependence.

  14. Characterization of active metamaterials based on negative impedance converters

    NASA Astrophysics Data System (ADS)

    Rajab, K. Z.; Fan, Y. F.; Hao, Y.

    2012-11-01

    Negative impedance converters (NICs) are used to create impedance loads that can effectively cancel the inductive properties of magnetic dipoles, resulting in active metamaterials with increased bandwidth and reduced loss for μ-near-zero (MNZ) and negative-Re(μ) (MNG) media. We demonstrate techniques for analyzing the stability and characterizing the magnetic properties of effective media loaded with NICs. Specifically, we apply the Nyquist criterion to validate the stability of sample active metamaterials. It is shown that the practical NIC-loaded metamaterial may maintain stability and reduce dispersion, albeit with reduced performance as compared to the ideal NIC load.

  15. National Ice Center Visiting Scientist Program

    NASA Technical Reports Server (NTRS)

    Austin, Meg

    2001-01-01

    The objectives of the work done by Dr. Kim Partington were to manage NASA's polar research program, including its strategic direction, research funding and interagency and international collaborations. The objectives of the UCAR Visiting Scientist Program at the National Ice Center (NIC) are to: (1) Manage a visiting scientist program for the NIC Science Center in support of the mission of the NIC; (2) Provide a pool of researchers who will share expertise with the NIC and the science community; (3) Facilitate communications between the research and operational communities for the purpose of identifying work ready for validation and transition to an operational environment; and (4) Act as a focus for interagency cooperation. The NIC mission is to provide worldwide operational sea ice analyses and forecasts for the armed forces of the US and allied nations, the Departments of Commerce and Transportation, and other US Government and international agencies, and the civil sector. The NIC produces these analyses and forecasts of Arctic, Antarctic, Great Lakes, and Chesapeake Bay ice conditions to support customers with global, regional, and tactical scale interests. The NIC regularly deploys Naval Ice Center NAVICECEN Ice Reconnaissance personnel to the Arctic and Antarctica in order to perform aerial ice observation and analysis in support of NIC customers. NIC ice data are a key part of the US contribution to international global climate and ocean observing systems.

  16. The benefits and drawbacks of nicotine exposure in the cortex and hippocampus of old rats.

    PubMed

    Barros, D M; Galhardi, F G; Ribas Ferreira, J L; Guterres, L B; Dickel, O; Geracitano, L A; Izquierdo, I; Monserrat, J M

    2007-05-01

    Nicotine is the main alkaloid of tobacco and possesses well-established stimulant effects. Previous reports show that nicotine at low doses improves memory functions, while high doses impair memory. This study aims to analyze the effects of nicotine (NIC) on inhibitory avoidance task and on DNA damage, reactive oxygen species (ROS) concentration, total antioxidant capacity, and lipid peroxidation in cortex and hippocampus of old rats. Male Wistar rats of 24-26 months old (620-700g) were exposed i.p. to two doses (0.3 and 1mg/kg) of NIC daily during 9 days. The treatment NIC 0.3 enhanced long-term memory (p<0.05), whereas NIC 1 improved both short and long-term memories (p<0.05). DNA damage was observed only in hippocampus (p<0.05) after NIC 1 exposure. A similar result was obtained for ROS: higher levels were detected at NIC 1 treatment in hippocampus (p<0.05). No alterations in the total antioxidant capacity were verified after NIC exposure (0.3 and 1mg/kg) in both tissues (p>0.05). Finally, evidence of oxidative damage was observed in terms of lipid peroxides levels, being higher at NIC 1 in hippocampus (p<0.05). Overall the results indicate that deleterious effects paralleled the improved short and long-term memories at the highest NIC dose, since augmented DNA damage, ROS concentration and lipid peroxides levels were registered. PMID:17350101

  17. The benefits and drawbacks of nicotine exposure in the cortex and hippocampus of old rats.

    PubMed

    Barros, D M; Galhardi, F G; Ribas Ferreira, J L; Guterres, L B; Dickel, O; Geracitano, L A; Izquierdo, I; Monserrat, J M

    2007-05-01

    Nicotine is the main alkaloid of tobacco and possesses well-established stimulant effects. Previous reports show that nicotine at low doses improves memory functions, while high doses impair memory. This study aims to analyze the effects of nicotine (NIC) on inhibitory avoidance task and on DNA damage, reactive oxygen species (ROS) concentration, total antioxidant capacity, and lipid peroxidation in cortex and hippocampus of old rats. Male Wistar rats of 24-26 months old (620-700g) were exposed i.p. to two doses (0.3 and 1mg/kg) of NIC daily during 9 days. The treatment NIC 0.3 enhanced long-term memory (p<0.05), whereas NIC 1 improved both short and long-term memories (p<0.05). DNA damage was observed only in hippocampus (p<0.05) after NIC 1 exposure. A similar result was obtained for ROS: higher levels were detected at NIC 1 treatment in hippocampus (p<0.05). No alterations in the total antioxidant capacity were verified after NIC exposure (0.3 and 1mg/kg) in both tissues (p>0.05). Finally, evidence of oxidative damage was observed in terms of lipid peroxides levels, being higher at NIC 1 in hippocampus (p<0.05). Overall the results indicate that deleterious effects paralleled the improved short and long-term memories at the highest NIC dose, since augmented DNA damage, ROS concentration and lipid peroxides levels were registered.

  18. A Calibration of NICMOS Camera 2 for Low Count Rates

    NASA Astrophysics Data System (ADS)

    Rubin, D.; Aldering, G.; Amanullah, R.; Barbary, K.; Dawson, K. S.; Deustua, S.; Faccioli, L.; Fadeyev, V.; Fakhouri, H. K.; Fruchter, A. S.; Gladders, M. D.; de Jong, R. S.; Koekemoer, A.; Krechmer, E.; Lidman, C.; Meyers, J.; Nordin, J.; Perlmutter, S.; Ripoche, P.; Schlegel, D. J.; Spadafora, A.; Suzuki, N.

    2015-05-01

    NICMOS 2 observations are crucial for constraining distances to most of the existing sample of z\\gt 1 SNe Ia. Unlike conventional calibration programs, these observations involve long exposure times and low count rates. Reciprocity failure is known to exist in HgCdTe devices and a correction for this effect has already been implemented for high and medium count rates. However, observations at faint count rates rely on extrapolations. Here instead, we provide a new zero-point calibration directly applicable to faint sources. This is obtained via inter-calibration of NIC2 F110W/F160W with the Wide Field Camera 3 (WFC3) in the low count-rate regime using z∼ 1 elliptical galaxies as tertiary calibrators. These objects have relatively simple near-IR spectral energy distributions, uniform colors, and their extended nature gives a superior signal-to-noise ratio at the same count rate than would stars. The use of extended objects also allows greater tolerances on point-spread function profiles. We find space telescope magnitude zero points (after the installation of the NICMOS cooling system, NCS) of 25.296\\+/- 0.022 for F110W and 25.803\\+/- 0.023 for F160W, both in agreement with the calibration extrapolated from count rates ≳1000 times larger (25.262 and 25.799). Before the installation of the NCS, we find 24.843\\+/- 0.025 for F110W and 25.498\\+/- 0.021 for F160W, also in agreement with the high-count-rate calibration (24.815 and 25.470). We also check the standard bandpasses of WFC3 and NICMOS 2 using a range of stars and galaxies at different colors and find mild tension for WFC3, limiting the accuracy of the zero points. To avoid human bias, our cross-calibration was “blinded” in that the fitted zero-point differences were hidden until the analysis was finalized. Based on observations with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by AURA, Inc., under NASA contract NAS 5-26555, under programs

  19. Toxicity of aerosols of nicotine and pyruvic acid (separate and combined) in Sprague-Dawley rats in a 28-day OECD 412 inhalation study and assessment of systems toxicology.

    PubMed

    Phillips, Blaine; Esposito, Marco; Verbeeck, Jan; Boué, Stéphanie; Iskandar, Anita; Vuillaume, Gregory; Leroy, Patrice; Krishnan, Subash; Kogel, Ulrike; Utan, Aneli; Schlage, Walter K; Bera, Monali; Veljkovic, Emilija; Hoeng, Julia; Peitsch, Manuel C; Vanscheeuwijck, Patrick

    2015-01-01

    Toxicity of nebulized nicotine (Nic) and nicotine/pyruvic acid mixtures (Nic/Pyr) was characterized in a 28-day Organization for Economic Co-operation and Development 412 inhalation study with additional transcriptomic and lipidomic analyses. Sprague-Dawley rats were nose-only exposed, 6 h/day, 5 days/week to filtered air, saline, nicotine (50 µg/l), sodium pyruvate (NaPyr, 33.9 µg/l) or equimolar Nic/Pyr mixtures (18, 25 and 50 µg nicotine/l). Saline and NaPyr caused no health effects, but rats exposed to nicotine-containing aerosols had decreased body weight gains and concentration-dependent increases in liver weight. Blood neutrophil counts were increased and lymphocyte counts decreased in rats exposed to nicotine; activities of alkaline phosphatase and alanine aminotransferase were increased, and levels of cholesterol and glucose decreased. The only histopathologic finding in non-respiratory tract organs was increased liver vacuolation and glycogen content. Respiratory tract findings upon nicotine exposure (but also some phosphate-buffered saline aerosol effects) were observed only in the larynx and were limited to adaptive changes. Gene expression changes in the lung and liver were very weak. Nic and Nic/Pyr caused few significant changes (including Cyp1a1 gene upregulation). Changes were predominantly related to energy metabolism and fatty acid metabolism but did not indicate an obvious toxicity-related response. Nicotine exposure lowered plasma lipids, including cholesteryl ester (CE) and free cholesterol and, in the liver, phospholipids and sphingolipids. Nic, NaPyr and Nic/Pyr decreased hepatic triacylglycerol and CE. In the lung, Nic and Nic/Pyr increased CE levels. These data suggest that only minor biologic effects related to inhalation of Nic or Nic/Pyr aerosols were observed in this 28-day study.

  20. Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice: A Comparison with Nicotinic Acid.

    PubMed

    Mateuszuk, Lukasz; Jasztal, Agnieszka; Maslak, Edyta; Gasior-Glogowska, Marlena; Baranska, Malgorzata; Sitek, Barbara; Kostogrys, Renata; Zakrzewska, Agnieszka; Kij, Agnieszka; Walczak, Maria; Chlopicki, Stefan

    2016-02-01

    1-Methylnicotinamide (MNA), the major endogenous metabolite of nicotinic acid (NicA), may partially contribute to the vasoprotective properties of NicA. Here we compared the antiatherosclerotic effects of MNA and NicA in apolipoprotein E (ApoE)/low-density lipoprotein receptor (LDLR)-deficient mice. ApoE/LDLR(-/-) mice were treated with MNA or NicA (100 mg/kg). Plaque size, macrophages, and cholesterol content in the brachiocephalic artery, endothelial function in the aorta, systemic inflammation, platelet activation, as well as the concentration of MNA and its metabolites in plasma and urine were measured. MNA and NicA reduced atherosclerotic plaque area, plaque inflammation, and cholesterol content in the brachiocephalic artery. The antiatherosclerotic actions of MNA and NicA were associated with improved endothelial function, as evidenced by a higher concentration of 6-keto-prostaglandin F1 α and nitrite/nitrate in the aortic ring effluent, inhibition of platelets (blunted thromboxane B2 generation), and inhibition of systemic inflammation (lower plasma concentration of serum amyloid P, haptoglobin). NicA treatment resulted in an approximately 2-fold higher concentration of MNA and its metabolites in urine and a 4-fold higher nicotinamide/MNA ratio in plasma, compared with MNA treatment. In summary; MNA displays pronounced antiatherosclerotic action in ApoE/LDLR(-/-) mice, an effect associated with an improvement in prostacyclin- and nitric oxide-dependent endothelial function, inhibition of platelet activation, inhibition of inflammatory burden in plaques, and diminished systemic inflammation. Despite substantially higher MNA availability after NicA treatment, compared with an equivalent dose of MNA, the antiatherosclerotic effect of NicA was not stronger. We suggest that detrimental effects of NicA or its metabolites other than MNA may limit beneficial effects of NicA-derived MNA.

  1. Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis.

    PubMed

    Brown, Dustin P; Rogers, Dennis T; Pomerleau, Francois; Siripurapu, Kirin B; Kulshrestha, Manish; Gerhardt, Greg A; Littleton, John M

    2016-06-01

    In screening a library of plant extracts from ~1000 species native to the Southeastern United States, Lobelia cardinalis was identified as containing nicotinic acetylcholine receptor (nicAchR) binding activity which was relatively non-selective for the α4β2- and α7-nicAchR subtypes. This nicAchR binding profile is atypical for plant-derived nicAchR ligands, the majority of which are highly selective for α4β2-nicAchRs. Its potential therapeutic relevance is noteworthy since agonism of α4β2- and α7-nicAchRs is associated with anti-inflammatory and neuroprotective properties. Bioassay-guided fractionation of L. cardinalis extracts led to the identification of lobinaline, a complex binitrogenous alkaloid, as the main source of the unique nicAchR binding profile. Purified lobinaline was a potent free radical scavenger, displayed similar binding affinity at α4β2- and α7-nicAchRs, exhibited agonist activity at nicAchRs in SH-SY5Y cells, and inhibited [(3)H]-dopamine (DA) uptake in rat striatal synaptosomes. Lobinaline significantly increased fractional [(3)H] release from superfused rat striatal slices preloaded with [(3)H]-DA, an effect that was inhibited by the non-selective nicAchR antagonist mecamylamine. In vivo electrochemical studies in urethane-anesthetized rats demonstrated that lobinaline locally applied in the striatum significantly prolonged clearance of exogenous DA by the dopamine transporter (DAT). In contrast, lobeline, the most thoroughly investigated Lobelia alkaloid, is an α4β2-nicAchR antagonist, a poor free radical scavenger, and is a less potent DAT inhibitor. These previously unreported multifunctional effects of lobinaline make it of interest as a lead to develop therapeutics for neuropathological disorders that involve free radical generation, cholinergic, and dopaminergic neurotransmission. These include neurodegenerative conditions, such as Parkinson's disease, and drug abuse. PMID:27105955

  2. Antiatherosclerotic Effects of 1-Methylnicotinamide in Apolipoprotein E/Low-Density Lipoprotein Receptor-Deficient Mice: A Comparison with Nicotinic Acid.

    PubMed

    Mateuszuk, Lukasz; Jasztal, Agnieszka; Maslak, Edyta; Gasior-Glogowska, Marlena; Baranska, Malgorzata; Sitek, Barbara; Kostogrys, Renata; Zakrzewska, Agnieszka; Kij, Agnieszka; Walczak, Maria; Chlopicki, Stefan

    2016-02-01

    1-Methylnicotinamide (MNA), the major endogenous metabolite of nicotinic acid (NicA), may partially contribute to the vasoprotective properties of NicA. Here we compared the antiatherosclerotic effects of MNA and NicA in apolipoprotein E (ApoE)/low-density lipoprotein receptor (LDLR)-deficient mice. ApoE/LDLR(-/-) mice were treated with MNA or NicA (100 mg/kg). Plaque size, macrophages, and cholesterol content in the brachiocephalic artery, endothelial function in the aorta, systemic inflammation, platelet activation, as well as the concentration of MNA and its metabolites in plasma and urine were measured. MNA and NicA reduced atherosclerotic plaque area, plaque inflammation, and cholesterol content in the brachiocephalic artery. The antiatherosclerotic actions of MNA and NicA were associated with improved endothelial function, as evidenced by a higher concentration of 6-keto-prostaglandin F1 α and nitrite/nitrate in the aortic ring effluent, inhibition of platelets (blunted thromboxane B2 generation), and inhibition of systemic inflammation (lower plasma concentration of serum amyloid P, haptoglobin). NicA treatment resulted in an approximately 2-fold higher concentration of MNA and its metabolites in urine and a 4-fold higher nicotinamide/MNA ratio in plasma, compared with MNA treatment. In summary; MNA displays pronounced antiatherosclerotic action in ApoE/LDLR(-/-) mice, an effect associated with an improvement in prostacyclin- and nitric oxide-dependent endothelial function, inhibition of platelet activation, inhibition of inflammatory burden in plaques, and diminished systemic inflammation. Despite substantially higher MNA availability after NicA treatment, compared with an equivalent dose of MNA, the antiatherosclerotic effect of NicA was not stronger. We suggest that detrimental effects of NicA or its metabolites other than MNA may limit beneficial effects of NicA-derived MNA. PMID:26631491

  3. Fluctuations in central and peripheral temperatures induced by intravenous nicotine: central and peripheral contributions.

    PubMed

    Tang, Jeremy S; Kiyatkin, Eugene A

    2011-04-01

    Nicotine (NIC) is a highly addictive substance that interacts with different subtypes of nicotinic acetylcholine receptors widely distributed in the central and peripheral nervous systems. While the direct action of NIC on central neurons appears to be essential for its reinforcing properties, the role of peripheral actions of this drug remains a matter of controversy. In this study, we examined changes in locomotor activity and temperature fluctuations in the brain (nucleus accumbens and ventral tegmental area), temporal muscle, and skin induced by intravenous (iv) NIC at low human-relevant doses (10 and 30μg/kg) in freely moving rats. These effects were compared to those induced by social interaction, an arousing procedure that induces behavioral activation and temperature responses via pure neural mechanisms, and iv injections of a peripherally acting NIC analog, NIC pyrrolidine methiodide (NIC-PM) used at equimolar doses. We found that NIC at 30μg/kg induces a modest locomotor activation, rapid and strong decrease in skin temperature, and weak increases in brain and muscle temperature. While these effects were qualitatively similar to those induced by social interaction, they were much weaker and showed a tendency to increase with repeated drug administrations. In contrast, NIC-PM did not affect locomotion and induced much weaker than NIC increases in brain and muscle temperatures and decreases in skin temperature; these effects showed a tendency to be weaker with repeated drug administrations. Our data indicate that NIC's actions in the brain are essential to induce locomotor activation and brain and body hyperthermic responses. However, rapid peripheral action of NIC on sensory afferents could be an important factor in triggering its central effects, contributing to neural and physiological activation following repeated drug use. PMID:21295014

  4. Mixtures of Complete and pif1- and pif2-Deficient Genotypes Are Required for Increased Potency of an Insect Nucleopolyhedrovirus▿

    PubMed Central

    Clavijo, Gabriel; Williams, Trevor; Simón, Oihane; Muñoz, Delia; Cerutti, Martine; López-Ferber, Miguel; Caballero, Primitivo

    2009-01-01

    The insecticidal potency of a nucleopolyhedrovirus population (SfNIC) that infects Spodoptera frugiperda (Lepidoptera) is greater than the potency of any of the component genotypes alone. Occlusion bodies (OBs) produced in mixed infections comprising the complete genotype and a deletion genotype are as pathogenic as the natural population of genotypes from the field. To test whether this increased potency was due to the deletion or to some other characteristic of the deletion variant genome, we used the SfNIC-B genome to construct a recombinant virus (SfNIC-BΔ16K) with the same 16.4-kb deletion as that observed in SfNIC-C and another recombinant (SfNIC-BΔpifs) with a deletion encompassing two adjacent genes (pif1 and pif2) that are essential for transmission per os. Mixtures comprising SfNIC-B and SfNIC-BΔ16K in OB ratios that varied between 10:90 and 90:10 were injected into insects, and the progeny OBs were fed to larvae in an insecticidal potency assay. A densitometric analysis of PCR products indicated that SfNIC-B was generally more abundant than expected in mixtures based on the proportions of OBs used to produce the inocula. Mixtures derived from OB ratios of 10, 25, or 50% of SfNIC-BΔ16K and the corresponding SfNIC-B proportions showed a significant increase in potency compared to SfNIC-B alone. The results of potency assays with mixtures comprising various proportions of SfNIC-B plus SfNIC-BΔpifs were almost identical to the results observed with SfNIC-BΔ16K, indicating that deletion of the pif gene region was responsible for the increased potency observed in mixtures of SfNIC-B and each deletion recombinant virus. Subsequently, mixtures produced from OB ratios involving 10 or 90% of SfNIC-BΔ16K with the corresponding proportions of SfNIC-B were subjected to four rounds of per os transmission in larvae. The composition of each experimental mixture rapidly converged to a common equilibrium with a genotypic composition of ∼85% SfNIC-B plus ∼15% SfNIC

  5. 78 FR 5757 - National Instant Criminal Background Check System

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-28

    ... Log records relating to denied transactions beyond 10 years, rather than transferring them to a... Records in the System (28 CFR 25.6(j)(3)) Proposal 3: Storage Location of NICS Audit Log records relating.... Proposal 3. Storage Location of NICS Audit Log Records Relating to Denied Transactions (28 CFR...

  6. 28 CFR 25.10 - Correction of erroneous system information.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal...

  7. 28 CFR 25.10 - Correction of erroneous system information.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal...

  8. 28 CFR 25.10 - Correction of erroneous system information.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal...

  9. 28 CFR 25.8 - System safeguards.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Index is stored electronically for use in an FBI computer environment. The NICS central computer will... proper use of dial-up circuits by FFLs will be included as part of the periodic audits by the FBI; and (3... number provided by the FBI; (2) FFLs will provide the NICS Representative with their FFL Number and...

  10. 28 CFR 25.10 - Correction of erroneous system information.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal...

  11. 28 CFR 25.10 - Correction of erroneous system information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... conducted the check of the NICS (the “denying agency,” which will be either the FBI or the state or local... application first to the denying agency, i.e., either the FBI or the POC. If the denying agency is unable to... challenge to the accuracy of the record, in writing, to the FBI, NICS Operations Center, Criminal...

  12. Report on Junior College Funding.

    ERIC Educational Resources Information Center

    Hay, Janet

    This report summarizes enrollment, costs, and funding information for North Idaho College (NIC) and the College of Southern Idaho (CSI) for 1972 and 1977, explores new options for the future, and presents academic and vocational division funding information and capital construction data. Academic student enrollment at NIC increased 35% between…

  13. Assessment of a Model for the Evaluation of Professional Non-Instruction Staff in Elementary Schools

    ERIC Educational Resources Information Center

    Hlavaty, Erica A.

    2013-01-01

    The purpose of this study was to help improve the evaluation system for school counselors and school psychologists, or non-instructional, certified staff (NICS). A mixed methodology approach was used to describe the existing evaluation system used to evaluate NICS; to develop a new system of evaluation based on recent research; and to determine…

  14. Planning Study for North Idaho College.

    ERIC Educational Resources Information Center

    Young, Raymond J.

    This three-part, long-range planning study was undertaken to assist North Idaho College (NIC) to more effectively meet the educational needs and interests of youth and adults residing in the five county Panhandle Area of Northern Idaho. Part I discusses NIC and its community; presents the results of a study of the educational plans and attitudes…

  15. Problematic Curriculum Development: Normative Inquiry in Curriculum.

    ERIC Educational Resources Information Center

    Berman, Louise M.

    1988-01-01

    Normative inquiry in curriculum (NIC) is concerned with a substantive, integrative approach to values so that the curriculum possesses integrity, consistency, and congruity. This article explores definitions and characteristics of NIC, analyzes the role of curricular influences and realities, provides suggestions for getting started, and answers…

  16. North Idaho College Long-Range Plan and Statement of Institutional Mission and Purpose.

    ERIC Educational Resources Information Center

    Cargol, Owen F.

    Based upon a planning project initiated at North Idaho College (NIC) in 1981 and approved by the Board of Trustees in 1982, this long-range plan states the mission of NIC and specifies goals and objectives to be attained in the next 3 years. First, introductory sections consider the qualities of a good long-range plan, address the responsibilities…

  17. 76 FR 58037 - Notice of Inventory Completion for Native American Human Remains and Associated Funerary Objects...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... described in another NIC published in the Federal Register (76 FR 35010-35012, June 15, 2011). The transfer... the cultural affiliation of two individuals described in a Notice of Inventory Completion (NIC) previously published in the Federal Register (34 FR 10906-10909, February 20, 2001). The Colorado...

  18. 75 FR 10554 - Privacy Act of 1974; System of Records Notice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... records, are published in the Federal Register at 65 FR 19476 (April 11, 2000), under ``Prefatory... Technologies, LLC (NIC). The PSP contractor will not be authorized to provide data to any persons other than... (PSP). Security Classification: Unclassified, Sensitive. System Location: NIC Primary Data Center...

  19. 77 FR 43118 - Solicitation for a Cooperative Agreement-Development of a Series of Publications for the Evidence...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Agreement. SUMMARY: The National Institute of Corrections (NIC) Community Services Division is soliciting proposals from organizations, groups, or individuals to enter into a cooperative agreement with NIC for up to 18 months beginning in October 2012. Work under this cooperative agreement is part of a larger...

  20. 28 CFR 25.8 - System safeguards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Index is stored electronically for use in an FBI computer environment. The NICS central computer will... data sources having access to the NICS. (c) State or local law enforcement agency computer centers... responsibilities of the Control Terminal Agencies and the computer centers include the following: (1) The...

  1. 76 FR 44369 - Solicitation for a Cooperative Agreement-Training and Related Assistance for Indian Country Jails

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... elements of jail administration, as taught in NIC's Jail Administration training program, (4) expertise and... availability to teach, along with their qualifications. NIC does not require that the same 3 trainers conduct... Assistance; a cover letter that identifies the audit agency responsible for the applicant's...

  2. 75 FR 1814 - Solicitation for a Cooperative Agreement-Curriculum Development: Training for Correctional...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... a curriculum, which follows NIC's Instructional Theory Into Practice (ITIP) model, to be written... curriculum will utilize blended learning formats to accommodate the possibility of distance learning. The... Agreement, a curriculum will have been developed using NIC's Instructional Theory Into Practice (ITIP)...

  3. 78 FR 19326 - Notice of Funding Availability for Calendar Year 2014 Competitive Grant Funds Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... applicants' Notice of Intent to Compete (NIC) on or before May 10, 2013, 5:00 p.m., E.T. Other key... and whose governing boards are controlled by locally elected officials. The RFP, containing the NIC...-1, CA-27, CA-28, NCA-1. Connecticut CT-1. Delaware MDE. District of Columbia DC-1. Illinois IL-3,...

  4. 78 FR 2438 - Agency Information Collection Activities; Existing Collection, Comments Requested: The National...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... Background Check System (NICS) Point-of-Contact (POC) State Final Determination Electronic Submission ACTION... National Instant Criminal Background Check System (NICS) Point-of-Contact (POC) State Final Determination... will be asked or required to respond, as well as a brief abstract: Primary: Full Point-of-Contact...

  5. 75 FR 61774 - Advisory Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE National Institute of Corrections Advisory Board Meeting Time and Date: 8 a.m. to 4:30 p.m. on Monday... Considered: Welcome New Advisory Board Members; NIC Orientation; Briefing on NIC Reports; Agency...

  6. 77 FR 62534 - Agency Information Collection Activities; Existing Collection, Comments Requested: Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... Requested: Federal Firearms Licensee (FFL) Enrollment/National Instant Criminal Background Check System... Background Check System (NICS) Section will be submitting the following information collection request to the... Acknowledgment of Responsibilities under the National Instant Criminal Background Check System (NICS) Form....

  7. 77 FR 63340 - Agency Information Collection Activities; Existing Collection, Comments Requested: Federal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Requested: Federal Firearms Licensee (FFL) Enrollment/National Instant Criminal Background Check System... Background Check System (NICS) Section will be submitting the following information collection request to the... Acknowledgment of Responsibilities under the National Instant Criminal Background Check System (NICS) Form...

  8. [Development of physical dependence on nicotine and endogenous opioid system--participation of α7 nicotinic acetylcholine receptor].

    PubMed

    Kishioka, Shiroh; Kiguchi, Norikazu; Kobayashi, Yuka; Saika, Fumihiro; Yamamoto, Chizuko

    2014-10-01

    Nicotine (NIC) regulates various cellular functions acting on the nicotinic acetylcholine receptor (nAChR). And nAChR consists of ligand-gated cation channels with pentameric structure and composed of α and β subunits. In the central nervous system, α 4 β 2 and α 7 nAChRs are the most abundantly expressed as nAChR subtypes. There are several lines of evidence indicating that systemic administration of NIC elicits the release of endogenous opioids, such as, endorphins, enkephalins and dynorphins, in the brain. NIC exerts numerous acute effects, for example, antinociceptive effects and the activating effects of the hypothalamic-pituitary-adrenal (HPA) axis. In these effects, NIC-induced antinociception, but not HPA axis activation, was inhibited by opioid receptor antagonist, naloxone (NLX), and was also suppressed in morphine tolerated mice, indicating the participation of the endogenous opioid system in NIC-induced antinociception, but not HPA axis activation. Moreover, NIC-induced antinociception was antagonized by both α 4 β 2 and α 7 nAChR antagonists, while NIC-induced HPA axis activation was antagonized by α 4 β 2 nAChR antagonist, but not by α 7 nAChR antagonist. These results suggest that the endogenous opioid system may not be located on the downstream of α 4 β 2 nAChR. On the other hand, NIC has substantial physical dependence liability. NLX elicits NIC withdrawal after repeated NIC administration evaluated by corticosterone increase as a withdrawal sign, and NLX-precipitated NIC withdrawal is inhibited by concomitant administration of other opioid receptor antagonist, naltrexone, indicating the participation of endogenous opioid system in the development of physical dependence on NIC. NLX-precipitated NIC withdrawal was also inhibited by concomitant administration of an α 7 nAChR antagonist, but not an α 4 β 2 nAChR antagonist. Taken together, these findings suggest that the endogenous opioid system may be located on the downstream of α 7

  9. [Development of physical dependence on nicotine and endogenous opioid system--participation of α7 nicotinic acetylcholine receptor].

    PubMed

    Kishioka, Shiroh; Kiguchi, Norikazu; Kobayashi, Yuka; Saika, Fumihiro; Yamamoto, Chizuko

    2014-10-01

    Nicotine (NIC) regulates various cellular functions acting on the nicotinic acetylcholine receptor (nAChR). And nAChR consists of ligand-gated cation channels with pentameric structure and composed of α and β subunits. In the central nervous system, α 4 β 2 and α 7 nAChRs are the most abundantly expressed as nAChR subtypes. There are several lines of evidence indicating that systemic administration of NIC elicits the release of endogenous opioids, such as, endorphins, enkephalins and dynorphins, in the brain. NIC exerts numerous acute effects, for example, antinociceptive effects and the activating effects of the hypothalamic-pituitary-adrenal (HPA) axis. In these effects, NIC-induced antinociception, but not HPA axis activation, was inhibited by opioid receptor antagonist, naloxone (NLX), and was also suppressed in morphine tolerated mice, indicating the participation of the endogenous opioid system in NIC-induced antinociception, but not HPA axis activation. Moreover, NIC-induced antinociception was antagonized by both α 4 β 2 and α 7 nAChR antagonists, while NIC-induced HPA axis activation was antagonized by α 4 β 2 nAChR antagonist, but not by α 7 nAChR antagonist. These results suggest that the endogenous opioid system may not be located on the downstream of α 4 β 2 nAChR. On the other hand, NIC has substantial physical dependence liability. NLX elicits NIC withdrawal after repeated NIC administration evaluated by corticosterone increase as a withdrawal sign, and NLX-precipitated NIC withdrawal is inhibited by concomitant administration of other opioid receptor antagonist, naltrexone, indicating the participation of endogenous opioid system in the development of physical dependence on NIC. NLX-precipitated NIC withdrawal was also inhibited by concomitant administration of an α 7 nAChR antagonist, but not an α 4 β 2 nAChR antagonist. Taken together, these findings suggest that the endogenous opioid system may be located on the downstream of α 7

  10. Development of an Oral Operant Nicotine/Ethanol Co-Use Model in Alcohol-Preferring (P) Rats

    PubMed Central

    Hauser, Sheketha R.; Katner, Simon N.; Deehan, Gerald A.; Ding, Zheng-Ming; Toalston, Jamie E.; Scott, Briana J.; Bell, Richard L.; McBride, William J.; Rodd, Zachary A.

    2012-01-01

    Background Alcohol abuse is frequently associated with nicotine use. The current experiments were conducted to establish an oral operant ethanol + nicotine (EtOH + Nic) co-use model, and to characterize some aspects of EtOH + Nic co-use. Methods: Rats were allowed to choose between EtOH alone or EtOH + Nic solutions. Additionally, P rats were allowed to concurrently self-administer 3 distinct EtOH solutions (10, 20, and 30%) with varying amounts of nicotine (0.07, 0.14, or 0.21 mg/ml) under operant conditions. P rats were also allowed to concurrently self-administer 2 distinct amounts of nicotine (0.07 and 0.14 mg/ml) added to saccharin (0.025%) solutions. Results During acquisition, P rats responded for the EtOH + Nic solutions at the same level as for EtOH alone, and responding for EtOH + Nic solutions was present throughout all drinking conditions. P rats also readily maintained stable self-administration behaviors for Nic + Sacc solutions. The results demonstrated that P rats readily acquired and maintained stable self-administration behaviors for EtOH + 0.07 and EtOH + 0.14 mg/ml Nic solutions. Self-administration of EtOH+ 0.21 mg/ml Nic was established in only 50% of the subjects. P rats readily expressed seeking behaviors for the EtOH + Nic solutions, and reacquired EtOH + Nic self-administration during relapse testing. In addition, tailblood samples indicated that EtOH + Nic co-use resulted in pharmacologically relevant levels of both EtOH and Nic in the blood. Discussion Overall, the results indicate that P rats readily consume EtOH + Nic solutions concurrently in the presence of EtOH alone, express drug-seeking behaviors, and will concurrently consume physiologically relevant levels of both drugs. These results support the idea that this oral operant EtOH + Nic co-use model would be suitable for studying the development of co-abuse and the consequences of long-term chronic co-abuse. PMID:22486609

  11. The investigation of the solvent effect on coordination of nicotinato ligand with cobalt(II) complex containing tris(2-benzimidazolylmethyl)amine: A computational study

    NASA Astrophysics Data System (ADS)

    Sayin, Koray; Karakaş, Duran

    2014-11-01

    The electronic structure of [Co(ntb)(nic)]+ complex ion are optimized by using density functional theory (DFT) method with mix basis set. Where (ntb) represents tris(2-benzimidazolylmethyl)amine ligand and (nic) is the anion of nicotinic acids. Six different fields, vacuum, chloroform, butanonitrile, methanol, water and formamide solvents are used in these calculations. The calculated structural parameters indicate that (nic) ligand coordinates to cobalt(II) containing (ntb) ligand with one oxygen atom in butanonitrile, methanol, water and formamide solvents but coordinates with two oxygen atoms in vacuum. These results are supported with IR, UV and 1H NMR spectra. According to the calculated results, the geometry of [Co(ntb)(nic)]+ complex ion is distorted octahedral in vacuum while the geometry is distorted square pyramidal in the all other solvents. Distorted octahedral [Co(ntb)(nic)]+ complex ion have not been synthesized as experimentally and it is predicted with computational chemistry methods.

  12. Full-gestational exposure to nicotine and ethanol augments nicotine self-administration by altering ventral tegmental dopaminergic function due to NMDA receptors in adolescent rats.

    PubMed

    Roguski, Emily E; Sharp, Burt M; Chen, Hao; Matta, Shannon G

    2014-03-01

    In adult rats, we have shown full-gestational exposure to nicotine and ethanol (Nic + EtOH) augmented nicotine self-administration (SA) (increased nicotine intake) compared to pair-fed (PF) offspring. Therefore, we hypothesized that full-gestational exposure to Nic + EtOH disrupts control of dopaminergic (DA) circuitry by ventral tegmental area (VTA) NMDA receptors, augmenting nicotine SA and DA release in nucleus accumbens (NAcc) of adolescents. Both NAcc DA and VTA glutamate release were hyper-responsive to intra-VTA NMDA in Nic + EtOH offspring versus PF (p = 0.03 and 0.02, respectively). Similarly, DA release was more responsive to i.v. nicotine in Nic + EtOH offspring (p = 0.02). Local DL-2-Amino-5-phosphonopentanoic acid sodium salt (AP5) (NMDA receptor antagonist) infusion into the VTA inhibited nicotine-stimulated DA release in Nic + EtOH and PF offspring. Nicotine SA was augmented in adolescent Nic + EtOH versus PF offspring (p = 0.000001). Daily VTA microinjections of AP5 reduced nicotine SA by Nic + EtOH offspring, without affecting PF (p = 0.000032). Indeed, nicotine SA in Nic + EtOH offspring receiving AP5 was not different from PF offspring. Both VTA mRNA transcripts and NMDA receptor subunit proteins were not altered in Nic + EtOH offspring. In summary, adolescent offspring exposed to gestational Nic + EtOH show markedly increased vulnerability to become dependent on nicotine. This reflects the enhanced function of a subpopulation of VTA NMDA receptors that confer greater nicotine-induced DA release in NAcc. We hypothesized that concurrent gestational exposure to nicotine and ethanol would disrupt the control of VTA dopaminergic circuitry by NMDA receptors. Resulting in the augmented nicotine self-administration (SA) in adolescent offspring.

  13. Determination of niclosamide residues in rainbow trout (Oncorhynchus mykiss) and channel catfish (Ictalurus punctatus) fillet tissue by high-performance liquid chromatography

    USGS Publications Warehouse

    Schreier, T.M.; Dawson, V.K.; Cho, Yirang; Spanjers, N.J.; Boogaard, M.A.

    2000-01-01

    Bayluscide [the ethanolamine salt of niclosamide (NIC)] is a registered piscicide used in combination with 3-(trifluoromethyl)-4-nitrophenol (TFM) to control sea lamprey populations in streams tributary to the Great Lakes. A high-performance liquid chromatography (HPLC) method was developed for the determination of NIC residues in muscle fillet tissues of fish exposed to NIC and TFM during sea lamprey control treatments. NIC was extracted from fortified channel catfish and rainbow trout fillet tissue with a series of acetone extractions and cleaned up on C-18 solid-phase extraction cartridges. NIC concentrations were determined by HPLC with detection at 360 and 335 nm for rainbow trout and catfish, respectively. Recovery of NIC from rainbow trout (n = 7) fortified at 0.04 mu g/g was 77 +/- 6.5% and from channel catfish (n = 7) fortified at 0.02 mu g/g was 113 +/- 11%. NIC detection limit was 0.0107 mu g/g for rainbow trout and 0.0063 mu g/g for catfish. Percent recovery of incurred radioactive residues by this method from catfish exposed to [C-14]NIC was 89.3 +/- 4.1%. Percent recoveries of NIC from fortified storage stability tissue samples for rainbow trout (n = 3) analyzed at 5 and 7.5 month periods were 78 +/- 5.1 and 68 +/- 2.4%, respectively. Percent recoveries of NIC from fortified storage stability tissue samples for channel catfish (n = 3) analyzed at 5 and 7.5 month periods were 88 +/- 13 and 76 +/- 21%, respectively.

  14. Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone.

    PubMed

    Hall, Brandon J; Cauley, Marty; Burke, Dennis A; Kiany, Abtin; Slotkin, Theodore A; Levin, Edward D

    2016-06-01

    Active maternal smoking has adverse effects on neurobehavioral development of the offspring, with nicotine (Nic) providing much of the underlying causative mechanism. To determine whether the lower exposures caused by second-hand smoke are deleterious, we administered tobacco smoke extract (TSE) to pregnant rats starting preconception and continued through the second postnatal week, corresponding to all 3 trimesters of fetal brain development. Dosing was adjusted to produce maternal plasma Nic concentrations encountered with second-hand smoke, an order of magnitude below those seen in active smokers. We then compared TSE effects to those of an equivalent dose of Nic alone, and to a 10-fold higher Nic dose. Gestational exposure to TSE and Nic significantly disrupted cognitive and behavioral function in behavioral tests given during adolescence and adulthood (postnatal weeks 4-40), producing hyperactivity, working memory deficits, and impairments in emotional processing, even at the low exposure levels corresponding to second-hand smoke. Although TSE effects were highly correlated with those of Nic, the effects of TSE were much larger than could be attributed to just the Nic in the mixture. Indeed, TSE effects more closely resembled those of the 10-fold higher Nic levels, but still exceeded their magnitude. In combination with our earlier findings, this study thus completes the chain of causation to prove that second-hand smoke exposure causes neurodevelopmental deficits, originating in disruption of neurodifferentiation, leading to miswiring of neuronal circuits, and as shown here, culminating in behavioral dysfunction. As low level exposure to Nic alone produced neurobehavioral teratology, 'harm reduction' Nic products do not abolish the potential for neurodevelopmental damage.

  15. Cognitive and Behavioral Impairments Evoked by Low-Level Exposure to Tobacco Smoke Components: Comparison with Nicotine Alone.

    PubMed

    Hall, Brandon J; Cauley, Marty; Burke, Dennis A; Kiany, Abtin; Slotkin, Theodore A; Levin, Edward D

    2016-06-01

    Active maternal smoking has adverse effects on neurobehavioral development of the offspring, with nicotine (Nic) providing much of the underlying causative mechanism. To determine whether the lower exposures caused by second-hand smoke are deleterious, we administered tobacco smoke extract (TSE) to pregnant rats starting preconception and continued through the second postnatal week, corresponding to all 3 trimesters of fetal brain development. Dosing was adjusted to produce maternal plasma Nic concentrations encountered with second-hand smoke, an order of magnitude below those seen in active smokers. We then compared TSE effects to those of an equivalent dose of Nic alone, and to a 10-fold higher Nic dose. Gestational exposure to TSE and Nic significantly disrupted cognitive and behavioral function in behavioral tests given during adolescence and adulthood (postnatal weeks 4-40), producing hyperactivity, working memory deficits, and impairments in emotional processing, even at the low exposure levels corresponding to second-hand smoke. Although TSE effects were highly correlated with those of Nic, the effects of TSE were much larger than could be attributed to just the Nic in the mixture. Indeed, TSE effects more closely resembled those of the 10-fold higher Nic levels, but still exceeded their magnitude. In combination with our earlier findings, this study thus completes the chain of causation to prove that second-hand smoke exposure causes neurodevelopmental deficits, originating in disruption of neurodifferentiation, leading to miswiring of neuronal circuits, and as shown here, culminating in behavioral dysfunction. As low level exposure to Nic alone produced neurobehavioral teratology, 'harm reduction' Nic products do not abolish the potential for neurodevelopmental damage. PMID:26919958

  16. Effect of pre- and postnatal nicotine exposure on vasopressinergic system in rats.

    PubMed

    Zbuzek, V K; Zbuzek, V

    1999-02-01

    Timed pregnant Sprague-Dawley rats were infused subcutaneously either with nicotine (NIC, 6 mg kg-1 day-1; n=17) or saline (control, n=15) on the 3rd day of gestation, via Alzet osmotic pumps, for 28 days. After the parturition, the pups of both, control and NIC infused dams, were each randomly divided into 2 groups and placed to be nursed as following: (1) control dams nursing pups born to control mother (control group); (2) control dams nursing pups born to NIC-infused mother (prenatal NIC group); (3) NIC-infused dams nursing pups born to control mother (postnatal NIC group); (4) NIC-infused dams nursing pups born to NIC-infused mother (pre- and postnatal NIC group). Vasopressin (VP) was measured by RIA in plasma, neurointermediate lobe (NIL) and hypothalamus (HT) in the pups of both sexes, at the following age: 0 (within 24 h after birth); 1, 2, 3, 4 and 6 weeks. At the age of 3, 4 and 6 weeks, the isolated NILs were individually superfused and VP was measured as a basal release and the response to a 10-min 56 mM potassium stimulation. A marked suppression in the activity of VP-ergic system was observed in both sexes of offspring exposed to NIC prenatally, being first detectable at the age of 3 weeks, when the HT-NIL system becomes fully developed. However, the significant changes were observed at the age of 6 weeks: decreased serum VP concentration, lower VP contents in the HT and NIL, and suppressed VP release, basal and stimulated, from the isolated NIL. Postnatal exposure to nicotine was ineffective.

  17. A Guide for Parents and Families about What Your 11th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Grado 11 Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  18. A Guide for Parents and Families about What Your 2nd Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 2do Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  19. A Guide for Parents and Families about What Your 1st Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 1er Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  20. A Guide for Parents and Families about What Your 6th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 6to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  1. A Guide for Parents and Families about What Your 7th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Septimo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  2. A Guide for Parents and Families about What Your 5th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 5to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  3. A Guide for Parents and Families about What Your 9th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Noveno Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  4. A Guide for Parents and Families about What Your 4th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 4to Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  5. A Guide for Parents and Families about What Your 3rd Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de 3er Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  6. A Guide for Parents and Families about What Your 8th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Octavo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Dept. of Education, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  7. A Guide for Parents and Families about What Your 12th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Grado 12 Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Education Oversight Committee, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  8. A Guide for Parents and Families about What Your 10th Grader Should Be Learning in School This Year. Don't Fail Your Children = Una Guia para los Padres y Familias Acerca de Lo Que Su Hijo de Decimo Grado Debe Aprender en la Escuela Este Ano. No Le Falle a Sus Hijos.

    ERIC Educational Resources Information Center

    South Carolina State Education Oversight Committee, Columbia.

    This guide, in English- and Spanish-language versions, shares with parents information about the South Carolina Curriculum Standards. The standards outline state requirements for children's learning and what students across the state should be able to do in certain subjects. The guide lists seven key reasons parents should be aware of the new…

  9. Viviremos! On the Road to Healthy Living: A Bilingual Curriculum on AIDS and HIV Prevention for Migrant Students (Grades 6-12) = El Camino Hacia la Salud: Un Programa de Estudio Bilingue sobre la Prevencion del SIDA y del VIH para Estudiantes Migrantes (Grados 6-12).

    ERIC Educational Resources Information Center

    VAMOS (Villarreal Analytical Management and Organizational Services), San Marcos, TX.

    This curriculum provides the basic information everyone needs to avoid HIV infection, but was specifically designed for Latino farmworker students in grades 6-7. The student materials are written in Spanish and English and may be used with older student or young adults, or in English-as-a-second-language courses. An introduction provides…

  10. Exploring Knowledge of English Speaking Strategies in 8th and 12th Graders (Exploración del conocimiento de las estrategias de expresión oral en inglés en estudiantes de los grados octavo y doceavo)

    ERIC Educational Resources Information Center

    Diaz Larenas, Claudio

    2011-01-01

    This article presents a research study that analyses eighth and twelfth graders' knowledge of speaking strategies to communicate in English. The Oral Communication Strategy Inventory, developed by Nakatani in 2006, was applied to 108 students belonging to the public, semi-public and private educational sectors in Chile. The findings show that…

  11. Una guia para los padres sobre lo mas importante: el logro academico plan de educacion de Maryland desde preescolar hasta el 12 grado, 2002-2003. (A Parent's Guide to Achievement Matters Most: Maryland's Plan for PreK-12 Education, 2002-2003).

    ERIC Educational Resources Information Center

    Maryland State Dept. of Education, Baltimore.

    To raise the achievement of every student in the state, Maryland implemented "Achievement Matters Most," a new plan for public elementary and secondary schools that sets goals in the areas of achievement, teaching, testing, safety, and family involvement in schools. This Spanish-language guide for parents outlines the goals and characteristics of…

  12. Promoting Tenth Graders' Reading Comprehension of Academic Texts in the English Class (Promoción de la comprensión de lectura de textos académicos de estudiantes de grado décimo en la clase de inglés)

    ERIC Educational Resources Information Center

    Quiroga Carrillo, Claudia

    2010-01-01

    This article reports on an action research project conducted in a public school in Bogotá, Colombia, with tenth grade students. We decided to develop it because of the students' needs as well as the em phasis of the PEI (Proyecto Educativo Institucional = School Institutional Project), which is based on the requisite of improving reading…

  13. Consejos para los Padres Sobre la Lectura: Informacion e Ideas para Ayudar a los Ninos Desde la Infancia Hasta Octavo Grado a Tener Exito en la Lectura (Tips for Parents about Reading: Information and Ideas for Helping Children through Grade Eight Succeed with Reading).

    ERIC Educational Resources Information Center

    Davis, Deborah; Lewis, Jan Patricia

    Noting that all parents want the best school experience for their children, this booklet, in Spanish, gives parents some ideas about what to expect at different ages and stages of reading development, suggestions for what parents can do at home, and a list of favorite books parents can find in most libraries for parents and children to read.…

  14. Improving Eleventh Graders' Reading Comprehension through Text Coding and Double Entry Organizer Reading Strategies (Mejoramiento de la comprensión lectora de estudiantes de grado once mediante las estrategias de lectura de codificación de texto y organizador de doble entrada)

    ERIC Educational Resources Information Center

    Mahecha, Rocío; Urrego, Stella; Lozano, Erika

    2011-01-01

    In this article we report on an innovation project developed with a group of eleventh graders at a public school in Bogotá. Its aim was to encourage students to improve reading comprehension of texts in English. It was conducted taking into account students' needs, interests and level of English. To do it, we implemented two reading…

  15. Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal.

    PubMed

    Varani, Andrés P; Pedrón, Valeria T; Machado, Lirane Moutinho; Antonelli, Marta C; Bettler, Bernhard; Balerio, Graciela N

    2015-03-01

    The nicotine (NIC) withdrawal syndrome is considered to be a major cause of the high relapse rate among individuals undergoing smoking cessation. The aim of the present study was to evaluate a possible role of GABAB receptors in NIC withdrawal, by comparing GABAB1 knockout mice and their wild-type littermates. We analysed the time course of the global withdrawal score, the anxiety-like effects, monoamine concentrations, the brain-derived neurotrophic factor (BDNF) expression, the corticosterone plasmatic levels and [(3)H]epibatidine binding sites during NIC withdrawal precipitated by mecamylamine, a nicotinic receptor antagonist (MEC). In NIC withdrawn wild-type mice, we observed a global withdrawal score, an anxiety-like effect in the elevated plus maze, a decrease of the striatal dopamine and 3,4-dihydroxyphenylacetic acid concentrations, an increase of corticosterone plasma levels, a reduction of BDNF expression in several brain areas and an increase of [(3)H]epibatidine binding sites in specific brain regions. Interestingly, the effects found in NIC withdrawn wild-type mice were absent in GABAB1 knockout mice, suggesting that GABAB1 subunit of the GABAB receptor is involved in the regulation of the behavioural and biochemical alterations induced by NIC withdrawal in mice. These results reveal an interaction between the GABAB receptors and the neurochemical systems through which NIC exerts its long-term effects.

  16. A high security double lock and key mechanism in HUH relaxases controls oriT-processing for plasmid conjugation

    PubMed Central

    Carballeira, José Daniel; González-Pérez, Blanca; Moncalián, Gabriel; de la Cruz, Fernando

    2014-01-01

    Relaxases act as DNA selection sieves in conjugative plasmid transfer. Most plasmid relaxases belong to the HUH endonuclease family. TrwC, the relaxase of plasmid R388, is the prototype of the HUH relaxase family, which also includes TraI of plasmid F. In this article we demonstrate that TrwC processes its target nic-site by means of a highly secure double lock and key mechanism. It is controlled both by TrwC–DNA intermolecular interactions and by intramolecular DNA interactions between several nic nucleotides. The sequence specificity map of the interaction between TrwC and DNA was determined by systematic mutagenesis using degenerate oligonucleotide libraries. The specificity map reveals the minimal nic sequence requirements for R388-based conjugation. Some nic-site sequence variants were still able to form the U-turn shape at the nic-site necessary for TrwC processing, as observed by X-ray crystallography. Moreover, purified TrwC relaxase effectively cleaved ssDNA as well as dsDNA substrates containing these mutant sequences. Since TrwC is able to catalyze DNA integration in a nic-site-containing DNA molecule, characterization of nic-site functionally active sequence variants should improve the search quality of potential target sequences for relaxase-mediated integration in any target genome. PMID:25123661

  17. Clustered Transcription Factor Genes Regulate Nicotine Biosynthesis in Tobacco[W][OA

    PubMed Central

    Shoji, Tsubasa; Kajikawa, Masataka; Hashimoto, Takashi

    2010-01-01

    Tobacco (Nicotiana tabacum) synthesizes nicotine and related pyridine alkaloids in the root, and their synthesis increases upon herbivory on the leaf via a jasmonate-mediated signaling cascade. Regulatory NIC loci that positively regulate nicotine biosynthesis have been genetically identified, and their mutant alleles have been used to breed low-nicotine tobacco varieties. Here, we report that the NIC2 locus, originally called locus B, comprises clustered transcription factor genes of an ethylene response factor (ERF) subfamily; in the nic2 mutant, at least seven ERF genes are deleted altogether. Overexpression, suppression, and dominant repression experiments using transgenic tobacco roots showed both functional redundancy and divergence among the NIC2-locus ERF genes. These transcription factors recognized a GCC-box element in the promoter of a nicotine pathway gene and specifically activated all known structural genes in the pathway. The NIC2-locus ERF genes are expressed in the root and upregulated by jasmonate with kinetics that are distinct among the members. Thus, gene duplication events generated a cluster of highly homologous transcription factor genes with transcriptional and functional diversity. The NIC2-locus ERFs are close homologs of ORCA3, a jasmonate-responsive transcriptional activator of indole alkaloid biosynthesis in Catharanthus roseus, indicating that the NIC2/ORCA3 ERF subfamily was recruited independently to regulate jasmonate-inducible secondary metabolism in distinct plant lineages. PMID:20959558

  18. Effects of Nicotine on Olfactogustatory Incentives: Preference, Palatability, and Operant Choice Tests

    PubMed Central

    2013-01-01

    Introduction: The use of additives in tobacco may capitalize on the incentive motivational properties of tastes and scents such as mint (menthol), vanilla, and strawberry. These incentives are intended to increase tobacco experimentation, but their salience may also be enhanced by the incentive amplifying effects of nicotine (NIC). The goal of the present studies was to investigate the potential interaction between the incentive amplifying effects of NIC and gustatory incentives. Methods: One of two discriminable tastes (grape or cherry Kool-Aid®; 0.05% wt/vol; unsweetened) was paired with sucrose (20% wt/vol; conditioned stimulus [CS+]) in deionized water, whereas the other taste (CS−) was presented in deionized water. Experiment 1 investigated the effects of NIC pretreatment on preference for the CS+ versus CS− in 2-bottle choice tests. Experiment 2 investigated the effects of NIC on palatability of the CS+ and CS− using orofacial taste reactions. Experiment 3 investigated the effects of NIC on reinforcement by the CS+ and CS− using a concurrent choice operant task. Results: NIC pretreatment robustly increased operant responding for the CS+ but did not alter responding for the CS− in the operant choice task (Experiment 3). However, NIC pretreatment did not alter intake or palatability of the CS+ or CS− (Experiments 1 and 2). Conclusions: NIC increases the reinforcing effects of gustatory incentive stimuli, even though these stimuli were not paired with NIC administration. The findings suggest that adding taste incentives to tobacco products may increase the attractiveness of these products to consumers and the probability of repeated use. PMID:23430737

  19. Mecamylamine-precipitated nicotine withdrawal syndrome and its prevention with baclofen: an autoradiographic study of α4β2 nicotinic acetylcholine receptors in mice.

    PubMed

    Varani, Andrés P; Antonelli, Marta C; Balerio, Graciela N

    2013-07-01

    A previous study from our laboratory showed that baclofen (BAC, GABAB receptor agonist) was able to prevent the behavioral expression of nicotine (NIC) withdrawal syndrome. To further investigate the mechanisms underlying this effect, we conducted this study, with the aims of analyzing α4β2 nicotinic receptor density during NIC withdrawal and, in case we found any changes, of determining whether they could be prevented by pretreatment with BAC. Swiss Webster albino mice received NIC (2.5 mg/kg, s.c.) 4 times daily, for 7 days. On the 8th day, NIC-treated mice received the nicotinic antagonist mecamylamine (MEC; 2 mg/kg, i.p.) 1 h after the last dose of NIC. A second group of NIC-treated mice received BAC (2 mg/kg, i.p.) prior to MEC administration. Thirty minutes after MEC, mice were sacrificed and brain autoradiography with [(3)H]epibatidine was carried out at five different anatomical levels. Autoradiographic mapping showed a significant increase of α4β2 nicotinic receptor labeling during NIC withdrawal in the nucleus accumbens shell (AcbSh), medial habenular nucleus (HbM), thalamic nuclei, dorsal lateral geniculate (DLG) nucleus, fasciculus retroflexus (fr), ventral tegmental area, interpeduncular nucleus and superior colliculus. BAC pretreatment prevented the increased α4β2 nicotinic receptor binding sites in the AcbSh, MHb, thalamic nuclei, DLG nucleus and fr. The present results suggest a relationship between BAC's preventive effect of the expression of NIC withdrawal signs, and its ability to restore the changes in α4β2 nicotinic receptor labeling, evidenced in specific brain areas in NIC withdrawn animals.

  20. Dimensionality of ICA in resting-state fMRI investigated by feature optimized classification of independent components with SVM.

    PubMed

    Wang, Yanlu; Li, Tie-Qiang

    2015-01-01

    Different machine learning algorithms have recently been used for assisting automated classification of independent component analysis (ICA) results from resting-state fMRI data. The success of this approach relies on identification of artifact components and meaningful functional networks. A limiting factor of ICA is the uncertainty of the number of independent components (NIC). We aim to develop a framework based on support vector machines (SVM) and optimized feature-selection for automated classification of independent components (ICs) and use the framework to investigate the effects of input NIC on the ICA results. Seven different resting-state fMRI datasets were studied. 18 features were devised by mimicking the empirical criteria for manual evaluation. The five most significant (p < 0.01) features were identified by general linear modeling and used to generate a classification model for the framework. This feature-optimized classification of ICs with SVM (FOCIS) framework was used to classify both group and single subject ICA results. The classification results obtained using FOCIS and previously published FSL-FIX were compared against manually evaluated results. On average the false negative rate in identifying artifact contaminated ICs for FOCIS and FSL-FIX were 98.27 and 92.34%, respectively. The number of artifact and functional network components increased almost linearly with the input NIC. Through tracking, we demonstrate that incrementing NIC affects most ICs when NIC < 33, whereas only a few limited ICs are affected by direct splitting when NIC is incremented beyond NIC > 40. For a given IC, its changes with increasing NIC are individually specific irrespective whether the component is a potential resting-state functional network or an artifact component. Using FOCIS, we investigated experimentally the ICA dimensionality of resting-state fMRI datasets and found that the input NIC can critically affect the ICA results of resting-state fMRI data.

  1. Impact of prenatal nicotine on the structure of midbrain dopamine regions in the rat.

    PubMed

    Omelchenko, Natalia; Roy, Priya; Balcita-Pedicino, Judith Joyce; Poloyac, Samuel; Sesack, Susan R

    2016-05-01

    In utero exposure of rats to nicotine (NIC) provides a useful animal model for studying the impact of smoking during pregnancy on human offspring. Certain sequelae of prenatal NIC exposure suggest an impact on the development of the midbrain dopamine (DA) system, which receives a robust cholinergic innervation from the mesopontine tegmentum. We therefore investigated whether prenatal NIC induced structural changes in cells and synapses within the midbrain that persisted into adulthood. Osmotic minipumps delivering either sodium bitartrate (vehicle; VEH) or NIC bitartrate at 2 mg/kg/day were implanted into nine timed-pregnant dams at E4. At birth, rat pups were culled to litters of six males each, and the litters were cross-fostered. Plasma levels of NIC and cotinine from killed pups provided evidence of NIC exposure in utero. Pups separated from dams at weaning showed a trend toward reduced locomotor activity at this time point but not when tested again in adulthood. Adult rats were killed for anatomical studies. Estimates of brain size and volume did not vary with NIC treatment. Midbrain sections stained for Nissl or by immunoperoxidase for tyrosine hydroxylase and analyzed using unbiased stereology revealed no changes in volume or cell number in the substantia nigra compacta or ventral tegmental area as a result of NIC exposure. Within the ventral tegmental area, electron microscopic physical disector analysis showed no significant differences in the number of axon terminals or the number of asymmetric (putative excitatory) or symmetric (putative inhibitory) synapses. Although too infrequent to estimate by unbiased stereology, no obvious difference in the proportion of cholinergic axons was noted in NIC- versus VEH-treated animals. These data suggest that activation of nicotinic receptors during prenatal development induces no significant modifications in the structure of cells in the ventral midbrain when assessed in adulthood.

  2. Prenatal nicotine and maternal deprivation stress de-regulate the development of CA1, CA3, and dentate gyrus neurons in hippocampus of infant rats.

    PubMed

    Wang, Hong; Gondré-Lewis, Marjorie C

    2013-01-01

    Adverse experiences by the developing fetus and in early childhood are associated with profound effects on learning, emotional behavior, and cognition as a whole. In this study we investigated the effects of prenatal nicotine exposure (NIC), postnatal maternal deprivation (MD) or the combination of the two (NIC+MD) to determine if hippocampal neuron development is modulated by exposure to drugs of abuse and/or stress. Growth of rat offspring exposed to MD alone or NIC+MD was repressed until after weaning. In CA1 but not CA3 of postnatal day 14 (P14) pups, MD increased pyramidal neurons, however, in dentate gyrus (DG), decreased granule neurons. NIC had no effect on neuron number in CA1, CA3 or DG. Unexpectedly, NIC plus MD combined caused a synergistic increase in the number of CA1 or CA3 neurons. Neuron density in CA regions was unaffected by treatment, but in the DG, granule neurons had a looser packing density after NIC, MD or NIC+MD exposure. When septotemporal axes were analyzed, the synergism of stress and drug exposure in CA1 and CA3 was associated with rostral, whereas MD effects were predominantly associated with caudal neurons. TUNEL labeling suggests no active apoptosis at P14, and doublecortin positive neurons and mossy fibers were diminished in NIC+MD relative to controls. The laterality of the effect of nicotine and/or maternal deprivation in right versus left hippocampus was also analyzed and found to be insiginificant. We report for the first time that early life stressors such as postnatal MD and prenatal NIC exposure, when combined, may exhibit synergistic consequences for CA1 and CA3 pyramidal neuron development, and a potential antagonistic influence on developing DG neurons. These results suggest that early stressors may modulate neurogenesis, apoptosis, or maturation of glutamatergic neurons in the hippocampus in a region-specific manner during critical periods of neurodevelopment.

  3. Fast and delayed locomotor response to acute high-dose nicotine administration in adult male rats.

    PubMed

    Jandová, K; Marešová, D; Pokorný, J

    2013-01-01

    The aim of the present study was to compare the immediate and delayed locomotor response to high-dose nicotine (NIC) administration in rats. The vertical and horizontal activity of behavior in adult male rats exposed to 1 mg/kg NIC or saline (SAL) were tested in a Laboras apparatus for one hour after drug application. Animals were then returned to their cages and housed for another seven days. After this period all animals were placed in Laboras again and their behavioral pattern was retested for another period of one hour (delayed response). Horizontal activity: immediately after nicotine administration animal were less mobile (first 2-minutes interval), when compared with controls. The immobilization effect of nicotine disappeared within 4 minutes and during whole first 10-minutes interval time spent by locomotion did not differ from controls. Locomotion activity of animals treated with nicotine increased robustly in following 10 minutes and remained significantly higher in 2nd, 3rd and 5th 10-minutes interval. Vertical activity: Rearing frequency was significantly lowered by NIC administration in first two minutes of the experiment and the same was found when the duration of rearing was analyzed. Lower rearing intensity of NIC treated animals disappeared in 4 minutes and was finally higher during whole test session as compared with controls. When duration of rearing was analyzed it was significantly longer in NIC treated animals. In majority of observed behavioral aspects there were no differences between NIC treated rats and controls seven days after NIC or SAL treatment. Our results reflect effect of NIC and we conclude that NIC significantly influences behavior of experimental animals.

  4. Independent, rapid and targeted loss of highly repetitive DNA in natural and synthetic allopolyploids of Nicotiana tabacum.

    PubMed

    Renny-Byfield, Simon; Kovařík, Ales; Chester, Michael; Nichols, Richard A; Macas, Jiri; Novák, Petr; Leitch, Andrew R

    2012-01-01

    Allopolyploidy (interspecific hybridisation and polyploidy) has played a significant role in the evolutionary history of angiosperms and can result in genomic, epigenetic and transcriptomic perturbations. We examine the immediate effects of allopolyploidy on repetitive DNA by comparing the genomes of synthetic and natural Nicotiana tabacum with diploid progenitors N. tomentosiformis (paternal progenitor) and N. sylvestris (maternal progenitor). Using next generation sequencing, a recently developed graph-based repeat identification pipeline, Southern blot and fluorescence in situ hybridisation (FISH) we characterise two highly repetitive DNA sequences (NicCL3 and NicCL7/30). Analysis of two independent high-throughput DNA sequencing datasets indicates NicCL3 forms 1.6-1.9% of the genome in N. tomentosiformis, sequences that occur in multiple, discontinuous tandem arrays scattered over several chromosomes. Abundance estimates, based on sequencing depth, indicate NicCL3 is almost absent in N. sylvestris and has been dramatically reduced in copy number in the allopolyploid N. tabacum. Surprisingly elimination of NicCL3 is repeated in some synthetic lines of N. tabacum in their forth generation. The retroelement NicCL7/30, which occurs interspersed with NicCL3, is also under-represented but to a much lesser degree, revealing targeted elimination of the latter. Analysis of paired-end sequencing data indicates the tandem component of NicCL3 has been preferentially removed in natural N. tabacum, increasing the proportion of the dispersed component. This occurs across multiple blocks of discontinuous repeats and based on the distribution of nucleotide similarity among NicCL3 units, was concurrent with rounds of sequence homogenisation. PMID:22606317

  5. Dimensionality of ICA in resting-state fMRI investigated by feature optimized classification of independent components with SVM

    PubMed Central

    Wang, Yanlu; Li, Tie-Qiang

    2015-01-01

    Different machine learning algorithms have recently been used for assisting automated classification of independent component analysis (ICA) results from resting-state fMRI data. The success of this approach relies on identification of artifact components and meaningful functional networks. A limiting factor of ICA is the uncertainty of the number of independent components (NIC). We aim to develop a framework based on support vector machines (SVM) and optimized feature-selection for automated classification of independent components (ICs) and use the framework to investigate the effects of input NIC on the ICA results. Seven different resting-state fMRI datasets were studied. 18 features were devised by mimicking the empirical criteria for manual evaluation. The five most significant (p < 0.01) features were identified by general linear modeling and used to generate a classification model for the framework. This feature-optimized classification of ICs with SVM (FOCIS) framework was used to classify both group and single subject ICA results. The classification results obtained using FOCIS and previously published FSL-FIX were compared against manually evaluated results. On average the false negative rate in identifying artifact contaminated ICs for FOCIS and FSL-FIX were 98.27 and 92.34%, respectively. The number of artifact and functional network components increased almost linearly with the input NIC. Through tracking, we demonstrate that incrementing NIC affects most ICs when NIC < 33, whereas only a few limited ICs are affected by direct splitting when NIC is incremented beyond NIC > 40. For a given IC, its changes with increasing NIC are individually specific irrespective whether the component is a potential resting-state functional network or an artifact component. Using FOCIS, we investigated experimentally the ICA dimensionality of resting-state fMRI datasets and found that the input NIC can critically affect the ICA results of resting-state fMRI data. PMID

  6. Anti-nicotine vaccines: Comparison of adjuvanted CRM197 and Qb-VLP conjugate formulations for immunogenicity and function in non-human primates.

    PubMed

    McCluskie, Michael J; Thorn, Jennifer; Gervais, David P; Stead, David R; Zhang, Ningli; Benoit, Michelle; Cartier, Janna; Kim, In-Jeong; Bhattacharya, Keshab; Finneman, Jari I; Merson, James R; Davis, Heather L

    2015-12-01

    Anti-nicotine vaccines comprise nicotine-like haptens conjugated to a carrier protein plus adjuvant(s). Unfortunately, those tested clinically have failed to improve overall long term quit rates. We had shown in mice that carrier, hapten, linker, hapten load (number of haptens per carrier molecule), aggregation and adducts, as well as adjuvants influence the function of antibodies (Ab) induced. Herein, we tested an optimized antigen, NIC7-CRM, comprised of 5-aminoethoxy-nicotine (NIC7) conjugated to genetically detoxified diphtheria toxin (CRM197), with hapten load of ~16, no aggregation (~100% monomer) and minimal adducts. NIC7-CRM was tested in non-human primates (NHP) and compared to NIC-VLP, which has the same hapten and carrier as the clinical-stage CYT002-NicQb but a slightly different linker and lower hapten load. With alum as sole adjuvant, NIC7-CRM was superior to NIC-VLP for Ab titer, avidity and ex vivo function (83% and 27% nicotine binding at 40ng/mL respectively), but equivalent for in vivo function after intravenous [IV] nicotine challenge (brain levels reduced ~10%). CpG adjuvant added to NIC7-CRM/alum further enhanced the Ab responses and both ex vivo function (100% bound) and in vivo function (~80% reduction in brain). Thus, both optimal antigen design and CpG adjuvant were required to achieve a highly functional vaccine. The compelling NHP data with NIC7-CRM with alum/CpG supported human testing, currently underway.

  7. Orchiectomy modifies the antidepressant-like response of nicotine in the forced swimming test.

    PubMed

    Bonilla-Jaime, H; Limón-Morales, O; Arteaga-Silva, M; Hernández-González, M; Guadarrama-Cruz, G; Alarcón-Aguilar, F; Vázquez-Palacios, G

    2010-11-01

    Several studies have demonstrated that nicotine (NIC) exhibits antidepressant-like effects. In addition, it has been suggested that sexual hormones participate in the antidepressant actions of antidepressives. The present study was designed to analyze the effect of orchiectomy and the supplementation of testosterone propionate (TP) or 17β-estradiol (E(2)) on the antidepressant properties of NIC using the forced swimming test (FST), as well as to determine possible changes in the FST during different time periods after orchiectomy. In order to evaluate the influences of orchiectomy on the effects of NIC, the study first evaluated the effects of different time periods on orchiectomized rats (15, 21, 30, 45 and 60 days) that were subjected to the FST. Then, different doses of NIC (0.2, 0.4, 0.8, 1.6 mg/kg, sc) were administered for 14 days to both intact and orchiectomized rats (after 21 day) which were then also subjected to the FST. Finally, the influence of the TP or E(2) supplementation on the antidepressant-like effect of NIC on orchiectomized rats (after 21 days) was also analyzed. Results reveal that orchiectomy significantly increased immobility behavior and decreased swimming and climbing up to 60 days after castration. In contrast, NIC decreased immobility behavior and increased swimming in intact rats; whereas orchiectomy suppressed this antidepressant effect of NIC. Only with E(2) supplementation was it possible to restore the sensitivity of the castrated rats to NIC. These results suggest that E(2) was able to facilitate the antidepressant response of NIC in orchiectomized rats.

  8. Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery.

    PubMed

    Pan, Wenhui; Qin, Mengyao; Zhang, Guoguang; Long, Yueming; Ruan, Wenyi; Pan, Jingtong; Wu, Zushuai; Wan, Tao; Wu, Chuanbin; Xu, Yuehong

    2016-01-01

    Tacrolimus (FK506), an effective immunosuppressant for treating inflammatory skin diseases, hardly penetrates into and through the skin owing to its high hydrophobicity and molecular weight. The aim of this study was to develop a hybrid system based on nicotinamide (NIC) and nanoparticles (NPs) encapsulating FK506, such as FK506-NPs-NIC, for facilitating percutaneous delivery, which exploited virtues of both NIC and NPs to obtain the synergetic effect. Solubility and percutaneous permeation studies were carried out. The results showed that NIC could increase the solubility and permeability of FK506 and that 20% (w/v) NIC presented higher FK506 permeability and was thus chosen as the hydrotropic solution to solubilize FK506 and prepare FK506-NPs-NIC. Hyaluronic acid (HA) was chemically conjugated with cholesterol (Chol) to obtain amphiphilic conjugate of HA-Chol, which self-assembled NPs in 20% NIC solution containing FK506. The particle size, zeta potential, and morphology of NPs were characterized. The encapsulation efficiency and in vitro percutaneous permeation of NPs were evaluated in the presence and absence of NIC. The results demonstrated that hydrotropic solubilizing FK506 was readily encapsulated into NPs with a higher encapsulation efficiency of 79.2%±4.2%, and the combination of NPs with NIC exhibited a significantly synergistic effect on FK506 deposition within the skin (2.39±0.53 μg/cm(2)) and penetration through the skin (13.38±2.26 μg/cm(2)). The effect of the combination of NPs with NIC on drug permeation was further visualized by confocal laser scanning microscope through in vivo permeation studies, and the results confirmed that NPs-NIC synergistically enhanced the permeation of the drug into the skin. The cellular uptake performed in HaCaT cells presented a promoting effect of NPs on cellular uptake. These overall results demonstrated that HA-Chol-NPs-NIC can synergistically improve the percutaneous delivery of FK506, and it is a novel

  9. Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery

    PubMed Central

    Pan, Wenhui; Qin, Mengyao; Zhang, Guoguang; Long, Yueming; Ruan, Wenyi; Pan, Jingtong; Wu, Zushuai; Wan, Tao; Wu, Chuanbin; Xu, Yuehong

    2016-01-01

    Tacrolimus (FK506), an effective immunosuppressant for treating inflammatory skin diseases, hardly penetrates into and through the skin owing to its high hydrophobicity and molecular weight. The aim of this study was to develop a hybrid system based on nicotinamide (NIC) and nanoparticles (NPs) encapsulating FK506, such as FK506–NPs–NIC, for facilitating percutaneous delivery, which exploited virtues of both NIC and NPs to obtain the synergetic effect. Solubility and percutaneous permeation studies were carried out. The results showed that NIC could increase the solubility and permeability of FK506 and that 20% (w/v) NIC presented higher FK506 permeability and was thus chosen as the hydrotropic solution to solubilize FK506 and prepare FK506–NPs–NIC. Hyaluronic acid (HA) was chemically conjugated with cholesterol (Chol) to obtain amphiphilic conjugate of HA–Chol, which self-assembled NPs in 20% NIC solution containing FK506. The particle size, zeta potential, and morphology of NPs were characterized. The encapsulation efficiency and in vitro percutaneous permeation of NPs were evaluated in the presence and absence of NIC. The results demonstrated that hydrotropic solubilizing FK506 was readily encapsulated into NPs with a higher encapsulation efficiency of 79.2%±4.2%, and the combination of NPs with NIC exhibited a significantly synergistic effect on FK506 deposition within the skin (2.39±0.53 μg/cm2) and penetration through the skin (13.38±2.26 μg/cm2). The effect of the combination of NPs with NIC on drug permeation was further visualized by confocal laser scanning microscope through in vivo permeation studies, and the results confirmed that NPs–NIC synergistically enhanced the permeation of the drug into the skin. The cellular uptake performed in HaCaT cells presented a promoting effect of NPs on cellular uptake. These overall results demonstrated that HA–Chol–NPs–NIC can synergistically improve the percutaneous delivery of FK506, and it is

  10. Combination of hydrotropic nicotinamide with nanoparticles for enhancing tacrolimus percutaneous delivery.

    PubMed

    Pan, Wenhui; Qin, Mengyao; Zhang, Guoguang; Long, Yueming; Ruan, Wenyi; Pan, Jingtong; Wu, Zushuai; Wan, Tao; Wu, Chuanbin; Xu, Yuehong

    2016-01-01

    Tacrolimus (FK506), an effective immunosuppressant for treating inflammatory skin diseases, hardly penetrates into and through the skin owing to its high hydrophobicity and molecular weight. The aim of this study was to develop a hybrid system based on nicotinamide (NIC) and nanoparticles (NPs) encapsulating FK506, such as FK506-NPs-NIC, for facilitating percutaneous delivery, which exploited virtues of both NIC and NPs to obtain the synergetic effect. Solubility and percutaneous permeation studies were carried out. The results showed that NIC could increase the solubility and permeability of FK506 and that 20% (w/v) NIC presented higher FK506 permeability and was thus chosen as the hydrotropic solution to solubilize FK506 and prepare FK506-NPs-NIC. Hyaluronic acid (HA) was chemically conjugated with cholesterol (Chol) to obtain amphiphilic conjugate of HA-Chol, which self-assembled NPs in 20% NIC solution containing FK506. The particle size, zeta potential, and morphology of NPs were characterized. The encapsulation efficiency and in vitro percutaneous permeation of NPs were evaluated in the presence and absence of NIC. The results demonstrated that hydrotropic solubilizing FK506 was readily encapsulated into NPs with a higher encapsulation efficiency of 79.2%±4.2%, and the combination of NPs with NIC exhibited a significantly synergistic effect on FK506 deposition within the skin (2.39±0.53 μg/cm(2)) and penetration through the skin (13.38±2.26 μg/cm(2)). The effect of the combination of NPs with NIC on drug permeation was further visualized by confocal laser scanning microscope through in vivo permeation studies, and the results confirmed that NPs-NIC synergistically enhanced the permeation of the drug into the skin. The cellular uptake performed in HaCaT cells presented a promoting effect of NPs on cellular uptake. These overall results demonstrated that HA-Chol-NPs-NIC can synergistically improve the percutaneous delivery of FK506, and it is a novel

  11. The influence of tobacco smoke and nicotine on antidepressant and memory-improving effects of venlafaxine.

    PubMed

    Nowakowska, Elzbieta; Kus, Krzysztof; Florek, Ewa; Czubak, Anna; Jodynis-Liebert, Jadwiga

    2006-04-01

    In experimental and clinical studies, central nicotinic systems have been shown to play an important role in cognitive function. Nicotinic acetylcholine receptors also mediate the reinforcing properties of nicotine (NIC) in tobacco products. A variety of studies have shown that acute treatment with NIC or nicotinic agonists can improve working memory function. Moreover, it is known that the monoaminergic system plays an important role in memory function. And there is evidence suggesting that prolonged use of NIC may exert antidepressant action via nicotinic receptors. The purpose of this study was to investigate the interactions between a novel antidepressant, venlafaxine (VEN), a blocker of noradrenaline and 5-hydroxytryptamine reuptake sites, and pure NIC in the context of antidepressant and memory function in tobacco smoke exposed and nonexposed rats. The animals were subjected to Porsolt's test for testing antidepressant activity and their memory function (spatial memory) was evaluated in the Morris Water Maze Test. In tobacco smoke non-exposed and exposed rats both single and chronic administration of VEN (20 mg/kg po) shortened immobility time. NIC (0.2 mg/kg sc) significantly reduced immobility time on the 1st, 7th and 14th test days in both non-exposed and exposed rats. Combined VEN+NIC treatment in tobacco smoke non-exposed rats reduced immobility too. This effect of the combination of drugs was significantly stronger as compared to the effects obtained after individual administration of VEN or NIC. In the group exposed to tobacco smoke, joint administration of VEN+ NIC induced a significant reduction of immobility as compared to the control and NIC groups. In the Morris Water Maze Test single and chronic administration of VEN, lower values of escape latencies and lower numbers of crossed quadrants were noted in both exposed and non-exposed rats, which indicates improved performance. After administering NIC we could observe improvement of spatial memory in

  12. AIDS nursing care and standardized nursing language: an application of the nursing intervention classification.

    PubMed

    Davis, K A

    1995-01-01

    Standardized nursing language is recommended increasingly as a method to describe the work of nursing, adapt to computerized documentation, and establish a place for nursing in national data bases. Nursing diagnosis has become a standard label for assessment data. The Iowa Interventions Project Research Team proposes that Nursing Interventions Classification (NIC) be adopted to label nursing interventions. The author applies NIC to HIV/AIDS nursing care guidelines from the literature and concludes that NIC can be an important tool as HIV/AIDS nurses develop and describe their knowledge base.

  13. 78 FR 35318 - Solicitation for a Cooperative Agreement-Corrections-Specific Resources for Extended Stakeholder...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ..., audio podcasts, videos, and/or photography. This project will be a collaborative venture with the NIC..., audio podcasts, videos, mobile apps, interactive maps, and/or photography, etc. that can be used as...

  14. Network Basics.

    ERIC Educational Resources Information Center

    Tennant, Roy

    1992-01-01

    Explains how users can find and access information resources available on the Internet. Highlights include network information centers (NICs); lists, both formal and informal; computer networking protocols, including international standards; electronic mail; remote log-in; and file transfer. (LRW)

  15. 28 CFR 70.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the performance of work under a funding agreement (“subject inventions”), as defined in 37 CFR part... Service (USMS), National Institute of Corrections (NIC), Office of Special Counsel (OSC), and the...

  16. Overview of the NSI User Support Office (NSI USO)

    NASA Technical Reports Server (NTRS)

    Jackson, Lenore A.

    1991-01-01

    Overview of the NSI User Support Office is presented in the form of view graphs. The following subject areas are covered: hot line for user questions; NSI data base updates; on-line services via NSI NIC; and toolkit distribution.

  17. Graphene-based tunable non-foster circuit for VHF applications

    NASA Astrophysics Data System (ADS)

    Tian, Jing; Nagarkoti, Deepak Singh; Rajab, Khalid Z.; Hao, Yang

    2016-06-01

    This paper presents a negative impedance converter (NIC) based on graphene field effect transistors (GFETs) for VHF applications. The NIC is designed following Linvill's open circuit stable (OCS) topology. The DC modelling parameters of GFET are extracted from a device measured by Meric et al. [IEEE Electron Devices Meeting, 23.2.1 (2010)] Estimated parasitics are also taken into account. Simulation results from Keysight Advanced Design System (ADS) show good NIC performance up to 200 MHz and the value of negative capacitance is directly proportional to the capacitive load. In addition, it has been shown that by varying the supply voltage the value of negative capacitance can also be tuned. The NIC stability has been tested up to 2 GHz (10 times the maximum operation frequency) using Nyquist stability criterion to ensure there are no oscillation issues.

  18. Building a Reliable Onboard Network with Ethernet: A GSFC Prototype

    NASA Technical Reports Server (NTRS)

    Marquart, Jane

    2004-01-01

    This viewgraph presentation discusses the architecture of an Ethernet-based communication network for spacecraft. The presentation also contains information on data link reliability, PDU formats, and NIC/OS Measurements.

  19. 28 CFR 25.8 - System safeguards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... data sources having access to the NICS. (c) State or local law enforcement agency computer centers... proper use of dial-up circuits by FFLs will be included as part of the periodic audits by the FBI; and...

  20. Magnetic properties and aromaticity of o-, m-, and p-benzyne.

    PubMed

    De Proft, Frank; von Ragué Schleyer, Paul; van Lenthe, Joop H; Stahl, Frank; Geerlings, Paul

    2002-08-01

    The relative aromaticities of the three singlet benzyne isomers, 1,2-, 1,3-, and 1,4-didehydrobenzenes have been evaluated with a series of aromaticity indicators, including magnetic susceptibility anisotropies and exaltations, nucleus-independent chemical shifts (NICS), and aromatic stabilization energies (all evaluated at the DFT level), as well as valence-bond Pauling resonance energies. Most of the criteria point to the o-benzyneNICS calculations reveal an aromatic transition state with a larger total NICS but a smaller NICS(pi) component and thus lower aromaticity than benzene.

  1. 28 CFR 25.6 - Accessing records in the system.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... a civil or criminal law enforcement activity relating to the Gun Control Act (18 U.S.C. Chapter 44... purposes, under 27 CFR part 178 recordkeeping requirements. The FBI NICS Operations Center response...

  2. 28 CFR 25.6 - Accessing records in the system.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a civil or criminal law enforcement activity relating to the Gun Control Act (18 U.S.C. Chapter 44... purposes, under 27 CFR part 178 recordkeeping requirements. The FBI NICS Operations Center response...

  3. 28 CFR 25.6 - Accessing records in the system.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a civil or criminal law enforcement activity relating to the Gun Control Act (18 U.S.C. Chapter 44... purposes, under 27 CFR part 178 recordkeeping requirements. The FBI NICS Operations Center response...

  4. 28 CFR 25.6 - Accessing records in the system.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... a civil or criminal law enforcement activity relating to the Gun Control Act (18 U.S.C. Chapter 44... purposes, under 27 CFR part 178 recordkeeping requirements. The FBI NICS Operations Center response...

  5. 28 CFR 25.6 - Accessing records in the system.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a civil or criminal law enforcement activity relating to the Gun Control Act (18 U.S.C. Chapter 44... purposes, under 27 CFR part 178 recordkeeping requirements. The FBI NICS Operations Center response...

  6. 78 FR 43923 - Solicitation for a Cooperative Agreement-Executive Excellence a Training and Development Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-22

    ... Excellence curriculum should be developed using NIC's Instructional Theory Into Practice (ITIP) model. The... aids, handouts, exercises, etc.). The use of blended learning tools such as live web-based...

  7. 75 FR 43983 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... be obtained from the National Information Center website at www.ffiec.gov/nic/ . Unless otherwise... financial advisory activities, pursuant to section 225.28(b)(6)(i) of Regulation Y. Board of Governors...

  8. 75 FR 17142 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... be obtained from the National Information Center website at www.ffiec.gov/nic/ . Unless otherwise... the offices of the Board of Governors not later than April 28, 2010. A. Federal Reserve Bank of...

  9. 75 FR 58387 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... be obtained from the National Information Center website at www.ffiec.gov/nic/ . Unless otherwise... servicing loans, pursuant to section 225.28(b)(1) of Regulation Y. Board of Governors of the Federal...

  10. 76 FR 30742 - Advisory Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... 27, 2011; 8 a.m. to 4:30 p.m. on Tuesday, June 28, 2011. Place: National Corrections Academy, 11900...; Discussion on NIC Board Hearings; Federal Partners Reports; Presentations and Demonstration by Academy...

  11. 75 FR 10490 - Joint Meeting of the Arthritis Drugs Advisory Committee and the Drug Safety and Risk Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... discuss new drug application (NDA) 22-478, naproxcinod0 375 milligram capsule, sponsored by NicOx S.A., a... be made to the contact person on or before April 28, 2010. Oral presentations from the public will...

  12. 75 FR 20849 - Notice of Proposals to Engage in Permissible Nonbanking Activities or to Acquire Companies that...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... nonbanking activity that is listed in Sec. 225.28 of Regulation Y (12 CFR 225.28) or that the Board has....ffiec.gov/nic/ . Unless otherwise noted, comments regarding the applications must be received at...

  13. 75 FR 30831 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... be obtained from the National Information Center website at www.ffiec.gov/nic/ . Unless otherwise... American State Bank, Arp, Texas. Board of Governors of the Federal Reserve System, May 28, 2010. Robert...

  14. 78 FR 4297 - Improving Availability of Relevant Executive Branch Records to the National Instant Criminal...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    .... (Presidential Sig.) THE WHITE HOUSE, Washington, January 16, 2013 [FR Doc. 2013-01274 Filed 1-18-13; 8:45 am... accuracy and efficiency of the NICS, increasing public safety by keeping guns out of the hands of...

  15. ISS Update: Robonaut 2 Handshake and Operations

    NASA Video Gallery

    NASA Public Affairs Officer Josh Byerly interviews Nic Radford, Robonaut Deputy Project Manager, talks about Robonaut's first hand shake in space, as well as what the future hold for the robot aboa...

  16. Propagation of electro-kinetic waves in magnetized GaN semiconductor with nano-sized ion colloids

    SciTech Connect

    Saxena, Ajay; Sharma, Giriraj; Jat, K. L.; Rishi, M. P.

    2015-07-31

    Based on hydrodynamic model of multi-component plasma, an analytical study on propagation of longitudinal electro-kinetic (LEK) waves in wurtzite and zincblende structures of GaN is carried out. Nano-sized ion colloids (NICs) are embedded in the sample by the technique of ion-implantation. The implanted NICs are considered massive by an order as compared to the host lattice points and do not participate in Based LEK perturbations. Though, the NICs are continuously bombarded by the electrons as well as the holes yet, the former acquires a net negative charge owing to relatively higher mobility of electrons and consequently results into depletion of electron density in the medium. It i s found that the presence of charged NICs significantly modifies the dispersion and amplification characteristics of LEK waves in magnetized GaN semiconductor plasma and their role becomes increasingly effective as the fraction of charge on them increases.

  17. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells.

    PubMed

    Zia, S; Ndoye, A; Nguyen, V T; Grando, S A

    1997-09-01

    The purpose of this study was to investigate the possibility of direct toxic effects of nicotine (Nic) on human bronchial epithelial cells (BEC) suggested by our previous findings of functional nicotinic acetylcholine receptors (nAChRs) in the epithelial cells lining mucocutaneous membranes. We now demonstrate for the first time that human and murine BEC both in vivo and in vitro express functional nAChRs, and that classic alpha 3, alpha 4, alpha 5 and alpha 7 subunits can contribute to formation of these acetylcholine-gated ion channels. In human bronchial and mouse lung tissues, and in cultures of human BEC, the nAChRs were visualized by subunit-specific antibodies on the cell membranes, particularly at the sites of cell-to-cell contacts. The epithelial cells of submucosal glands abundantly expressed alpha 7 nAChRs. Smoking significantly (p < 0.05) increased the relative numbers of nAChRs, and this effects could be reproduced in cultures of BEC exposed to 10 microM Nic. At a higher dose, Nic decreased the relative numbers of alpha 5-containing nAChRs, suggesting a role for receptor desensitization. The function of the nAChR channels expressed by BEC was demonstrated by biphasic increase in the concentrations of intracellular calcium ([Ca++]i) in response to activation of the channel by Nic and fluctuations of [Ca++]i due to channel blockade by mecamylamine (Mec). Long-term exposure to milimolar concentrations of Nic resulted in a steady increase of [Ca++]i, which may lead to cell damage. The biological roles of epithelial nAChRs apparently involve regulation of cell-to-cell communications, adhesion and motility, because Mec caused rapid and profound changes in these cell functions which were reversible by Nic. An over exposure of BEC to Nic, however, produced an antagonist-like effect, suggesting that the pathobiological effects of Nic toxicity might result from both activation of nAChR channels and nAChR desensitization. We conclude that medical consequences of

  18. Method development and validation for the simultaneous determination of cinnarizine and co-formulated drugs in pharmaceutical preparations by capillary electrophoresis.

    PubMed

    Abdelal, A A; Kitagawa, S; Ohtani, H; El-Enany, N; Belal, F; Walash, M I

    2008-02-13

    Rapid and simple capillary electrophoresis (CE) methods were developed for the simultaneous determinations of cinnarizine and domperidone (CN/DOM) and cinnarizine and nicergoline (CN/NIC) in their co-formulated tablets. The optimized CE conditions were as follows: running buffer, methanol-acetate buffer (pH 3.0, 10 mM) (80:20 and 85:15 (v/v) for CN/DOM and CN/NIC, respectively); applied voltage, 20 kV; UV detection wavelengths, 215 and 227 nm for CN/DOM and CN/NIC, respectively; hydrodynamic injection was performed at a height of 25 mm for 30 s. Quinine hydrochloride and nicardipine hydrochloride were used as internal standards for the determination of CN/DOM and CN/NIC, respectively. Calibration curves were linear over the ranges 0.25-20/0.375-15 microg/ml (CN/DOM) and 0.25-25/0.4-10 microg/ml (CN/NIC) in each optimized condition. Detection limits were 0.074/0.119 microg/ml and 0.072/0.116 microg/ml for CN/DOM and CN/NIC, respectively. The proposed methods were successfully applied for the simultaneous determination of both CN/DOM and CN/NIC in their co-formulated tablets without interfering peaks due to the excipients present in the pharmaceutical tablets. The estimated amounts of CN/DOM and CN/NIC were almost identical with the certified values, and their percentage relative standard deviation values (%R.S.D.) were found to be < or =2.34% (n=3). PMID:18164891

  19. Proton Single Event Effects (SEE) Testing of the Myrinet Crossbar Switch and Network Interface Card

    NASA Technical Reports Server (NTRS)

    Howard, James W., Jr.; LaBel, Kenneth A.; Carts, Martin A.; Stattel, Ronald; Irwin, Timothy L.; Day, John H. (Technical Monitor)

    2002-01-01

    As part of the Remote Exploration and Experimentation Project (REE), work was performed to do a proton SEE (Single Event Effect) evaluation of the Myricom network protocol system (Myrinet). This testing included the evaluation of the Myrinet crossbar switch and the Network Interface Card (NIC). To this end, two crossbar switch devices and five components in the NIC were exposed to the proton beam at the University of California at Davis Crocker Nuclear Laboratory (CNL).

  20. N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats.

    PubMed

    Okamura, Adriana Mary Nunes Costa; Gomes, Patrícia Xavier L; de Oliveira, Gersilene V; de Araújo, Fernanda Yvelize R; Tomaz, Viviane S; Chaves Filho, Adriano José Maia; de Sousa, Francisca Cléa F; Vasconcelos, Silvânia Maria Mendes; de Lucena, David Freitas; Macêdo, Danielle

    2016-06-01

    Kindling is a form of behavioral sensitization that is related to the progression of several neuropsychiatric disorders such as bipolar disorder. We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To do this female Wistar rats at postnatal day 30 received repeated injections of NIC 2mg/kg, i.p. every weekday for up to 19 days. NAC90, 180 or 270 mg/kg, i.p. was administered 30 min before NIC. The levels of glutathione (GSH), superoxide dismutase (SOD) activity, lipid peroxidation (LP) and nitrite were determined in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). The development of kindling occurred at a median time of 16.5 days with 87.5% of NIC animals presenting stage 5 seizures in the last day of drug administration. NAC270 prevented the occurrence of kindling. NIC-kindled animals presented decreased levels of GSH and increased LP in the PFC, HC and ST, while SOD activity was decreased in the ST. NAC180 or 270 prevented the alterations in GSH induced by NIC, but only NAC270 prevented the alterations in LP. Nitrite levels increased in the ST of NAC270 pretreated NIC-kindled animals. Taken together we demonstrated that NAC presents anti-kindling effects in female animals partially through the restoration of oxidative alterations.

  1. Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy.

    PubMed

    Shah, Ravi V; Kato, Shingo; Roujol, Sebastien; Murthy, Venkatesh; Bellm, Steven; Kashem, Abyaad; Basha, Tamer; Jang, Jihye; Eisman, Aaron S; Manning, Warren J; Nezafat, Reza

    2016-01-15

    Diffuse myocardial fibrosis is involved in the pathology of nonischemic cardiomyopathy (NIC). Recently, the application of native (noncontrast) myocardial T1 measurement has been proposed as a method for characterizing diffuse interstitial fibrosis. To determine the association of native T1 with myocardial structure and function, we prospectively studied 39 patients with NIC (defined as left ventricular ejection fraction (LVEF) ≤ 50% without cardiac magnetic resonance (CMR) evidence of previous infarction) and 27 subjects with normal LVEF without known overt cardiovascular disease. T1, T2, and extracellular volume fraction (ECV) were determined over 16 segments across the base, mid, and apical left ventricular (LV). NIC participants (57 ± 15 years) were predominantly men (74%), with a mean LVEF 34 ± 10%. Subjects with NIC had a greater native T1 (1,131 ± 51 vs 1,069 ± 29 ms; p <0.0001), a greater ECV (0.28 ± 0.04 vs 0.25 ± 0.02, p = 0.002), and a longer myocardial T2 (52 ± 8 vs 47 ± 5 ms; p = 0.02). After multivariate adjustment, a lower global native T1 time in NIC was associated with a greater LVEF (β = -0.59, p = 0.0003), greater right ventricular ejection fraction (β = -0.47, p = 0.006), and smaller left atrial volume index (β = 0.51, p = 0.001). The regional distribution of native myocardial T1 was similar in patients with and without NIC. In NIC, native myocardial T1 is elevated in all myocardial segments, suggesting a global (not regional) abnormality of myocardial tissue composition. In conclusion, native T1 may represent a rapid, noncontrast alternative to ECV for delineating myocardial tissue remodeling in NIC.

  2. Nicotine molecularly imprinted polymer: synergy of coordination and hydrogen bonding.

    PubMed

    Huynh, Tan-Phat; B K C, Chandra; Sosnowska, Marta; Sobczak, Janusz W; Nesterov, Vladimir N; D'Souza, Francis; Kutner, Wlodzimierz

    2015-02-15

    Two new bis(2,2'-bithienyl)methane derivatives, one with the zinc phthalocyanine substituent (ZnPc-S16) and the other with the 2-hydroxyethyl substituent (EtOH-S4), were synthesized to serve as functional monomers for biomimetic recognition of nicotine (Nic) by molecular imprinting. Formation of a pre-polymerization complex of the Nic template with ZnPc-S16 and EtOH-S4 was confirmed by both the high negative Gibbs free energy gain, ΔG = -115.95 kJ/mol, calculated using the density functional theory at the B3LYP/3-21G* level, and the high stability constant, Ks = 4.67 × 10(5) M(-1), determined by UV-vis titration in chloroform. A solution of this complex was used to deposit a Nic-templated molecularly imprinted polymer (MIP-Nic) film on an Au electrode of a quartz crystal resonator of EQCM by potentiodynamic electropolymerization. The imprinting factor was as high as ~9.9. Complexation of the Nic molecules by the MIP cavities was monitored with X-ray photoelectron spectroscopy (XPS), as manifested by a negative shift of the binding energy of the Zn 2p3/2 electron of ZnPc-S16 after Nic templating. For sensing applications, simultaneous chronoamperometry (CA) and piezoelectric microgravimetry (PM) measurements were performed under flow-injection analysis conditions. The limit of detection of the CA and PM chemosensing was as low as 40 and 12 µM, respectively. Among them, the CA chemosensing was more selective to the cotinine and myosmine interferences due to the 1.10 V vs. Ag/AgCl discriminating potential of nicotine electro-oxidation applied. Differences in selectivity to the analyte and interferences were interpreted by modeling complexation of Nic and, separately, each of the interferences with a "frozen" MIP-Nic molecular cavity.

  3. Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine.

    PubMed

    Hosaka, Takuomi; Sekimoto, Masashi; Nemoto, Kiyomitsu; Degawa, Masakuni

    2010-03-01

    The abilities of the dihydropyridine calcium channel blocker nicardipine (Nic) to induce cytochrome P450 1 family enzymes (CYP1s) and to enhance the 3-methylcholanthrene (MC)-mediated induction of CYP1s and formation of MC-DNA adduct were examined in the human hepatoma cell line HepG2. The results from real time RT-PCR analysis demonstrated that Nic could induce CYP1 mRNAs and enhance the MC-mediated induction of the CYP1 mRNAs. The luciferase-reporter gene assay using the HepG2-A10 cell line, which has been previously established for the screening of aryl hydrocarbon receptor (AhR) activators, also indicated the augmentation of MC-mediated activation of AhR (induction of luciferase) by Nic, although Nic showed limited capacity for the activation of AhR. Furthermore, the results from the Western blot analysis of CYP1s, the enzyme activity assay, and the assay for MC-DNA adduct formation indicated that Nic could enhance the MC-mediated induction of CYP1s, especially CYP1A1. Furthermore, the intracellular accumulation level of [(3)H]MC after treatment of HepG2 cells with [(3)H]MC significantly increased in the presence of Nic. The present findings demonstrate that Nic can enhance the MC-mediated induction of CYP1s, especially CYP1A1, and the formation of MC-DNA adduct in HepG2 cells. Furthermore, the augmentation of the MC-mediated bioactivation by Nic is demonstrated to occur mainly through an increase in intracellular accumulation of MC. PMID:20067464

  4. Changes in Genetic and Environmental Influences on the Development of Nicotine Dependence and Major Depressive Disorder from Middle Adolescence to Early Adulthood

    PubMed Central

    Tully, Erin C.; Iacono, William G.; McGue, Matt

    2010-01-01

    This longitudinal study used a representative community sample of same-sex twins (485 MZ pairs, 271 DZ pairs) to study longitudinal changes in genetic and environmental influences on nicotine dependence (NicD) symptoms and major depressive disorder (MDD) symptoms and the longitudinal relationships between NicD and MDD symptoms at three relatively discrete ages spanning middle adolescence to early adulthood (ages 15, 18, and 21). Clinical interviews were used to assess NicD and MDD symptoms lifetime at age 15 and during the previous three years at the two subsequent assessments. Biometric models revealed similar patterns of findings for NicD and MDD. Heritability increased with age, particularly between ages 15 and 18. Shared environmental influences were small, and the proportion of variance attributed to shared environmental influences decreased with age. Nonshared environmental influences were moderate to large in magnitude and were entirely age-specific. Both NicD and MDD symptoms showed considerable stability from age 15 to 21, and at each age those with one disorder showed elevated rates of the other. However, a cross-lagged model revealed no longitudinal predictive relationships between MDD symptoms and NicD symptoms after accounting for stability of symptoms within disorders. In summary, the transition between middle and late adolescence is a critical period for developmental shifts in the magnitudes of genetic and environmental influences on both MDD and NicD symptoms. Despite similarities in the development of genetic and environmental influences for the two phenotypes, the association between NicD and MDD reflects concurrent covariation rather than one phenotype being an antecedent influence on the subsequent development of the other. PMID:20883585

  5. Native Myocardial T1 as a Biomarker of Cardiac Structure in Non-Ischemic Cardiomyopathy.

    PubMed

    Shah, Ravi V; Kato, Shingo; Roujol, Sebastien; Murthy, Venkatesh; Bellm, Steven; Kashem, Abyaad; Basha, Tamer; Jang, Jihye; Eisman, Aaron S; Manning, Warren J; Nezafat, Reza

    2016-01-15

    Diffuse myocardial fibrosis is involved in the pathology of nonischemic cardiomyopathy (NIC). Recently, the application of native (noncontrast) myocardial T1 measurement has been proposed as a method for characterizing diffuse interstitial fibrosis. To determine the association of native T1 with myocardial structure and function, we prospectively studied 39 patients with NIC (defined as left ventricular ejection fraction (LVEF) ≤ 50% without cardiac magnetic resonance (CMR) evidence of previous infarction) and 27 subjects with normal LVEF without known overt cardiovascular disease. T1, T2, and extracellular volume fraction (ECV) were determined over 16 segments across the base, mid, and apical left ventricular (LV). NIC participants (57 ± 15 years) were predominantly men (74%), with a mean LVEF 34 ± 10%. Subjects with NIC had a greater native T1 (1,131 ± 51 vs 1,069 ± 29 ms; p <0.0001), a greater ECV (0.28 ± 0.04 vs 0.25 ± 0.02, p = 0.002), and a longer myocardial T2 (52 ± 8 vs 47 ± 5 ms; p = 0.02). After multivariate adjustment, a lower global native T1 time in NIC was associated with a greater LVEF (β = -0.59, p = 0.0003), greater right ventricular ejection fraction (β = -0.47, p = 0.006), and smaller left atrial volume index (β = 0.51, p = 0.001). The regional distribution of native myocardial T1 was similar in patients with and without NIC. In NIC, native myocardial T1 is elevated in all myocardial segments, suggesting a global (not regional) abnormality of myocardial tissue composition. In conclusion, native T1 may represent a rapid, noncontrast alternative to ECV for delineating myocardial tissue remodeling in NIC. PMID:26684511

  6. Near infra red spectroscopy as a multivariate process analytical tool for predicting pharmaceutical co-crystal concentration.

    PubMed

    Wood, Clive; Alwati, Abdolati; Halsey, Sheelagh; Gough, Tim; Brown, Elaine; Kelly, Adrian; Paradkar, Anant

    2016-09-10

    The use of near infra red spectroscopy to predict the concentration of two pharmaceutical co-crystals; 1:1 ibuprofen-nicotinamide (IBU-NIC) and 1:1 carbamazepine-nicotinamide (CBZ-NIC) has been evaluated. A partial least squares (PLS) regression model was developed for both co-crystal pairs using sets of standard samples to create calibration and validation data sets with which to build and validate the models. Parameters such as the root mean square error of calibration (RMSEC), root mean square error of prediction (RMSEP) and correlation coefficient were used to assess the accuracy and linearity of the models. Accurate PLS regression models were created for both co-crystal pairs which can be used to predict the co-crystal concentration in a powder mixture of the co-crystal and the active pharmaceutical ingredient (API). The IBU-NIC model had smaller errors than the CBZ-NIC model, possibly due to the complex CBZ-NIC spectra which could reflect the different arrangement of hydrogen bonding associated with the co-crystal compared to the IBU-NIC co-crystal. These results suggest that NIR spectroscopy can be used as a PAT tool during a variety of pharmaceutical co-crystal manufacturing methods and the presented data will facilitate future offline and in-line NIR studies involving pharmaceutical co-crystals. PMID:27429366

  7. Bimetallic poly- and oligo-nuclear complexes based on a rhodium(III) metalloligand

    NASA Astrophysics Data System (ADS)

    Vasilchenko, Danila B.; Venediktov, Anatoliy B.; Korenev, Sergey V.; Filatov, Evgeniy Yu.; Baidina, Iraida A.; Nadolinnyi, Vladimir A.

    2012-10-01

    Interaction of trans-[Rh(i-Nic)4Cl2]3- anions (i-Nic- - isonicotinate anion) with Cuaq2+ and Coaq2+ cations in water has afforded complex salts Co3[Rh(i-Nic)4Cl2]2·17H2O (1) and Cu3[Rh(i-Nic)4Cl2]2·14H2O (2). Oligonuclear character of 1 and 2 has been established. A coordination polymer Cu5[Rh(i-Nic)4Cl2]2(i-Nic)2(OH)2·2H2O (3) has been crystallized by hydrothermal treatment of 2 at 160 °C, and its structure was determined by X-ray structural analysis. EPR data for the complexes has been collected and interpreted. Thermal decomposition of the salts was studied by c-DTA. Bimetallic alloys rhodium-copper and rhodium-cobalt have been obtained as final products of thermal decomposition.

  8. Near infra red spectroscopy as a multivariate process analytical tool for predicting pharmaceutical co-crystal concentration.

    PubMed

    Wood, Clive; Alwati, Abdolati; Halsey, Sheelagh; Gough, Tim; Brown, Elaine; Kelly, Adrian; Paradkar, Anant

    2016-09-10

    The use of near infra red spectroscopy to predict the concentration of two pharmaceutical co-crystals; 1:1 ibuprofen-nicotinamide (IBU-NIC) and 1:1 carbamazepine-nicotinamide (CBZ-NIC) has been evaluated. A partial least squares (PLS) regression model was developed for both co-crystal pairs using sets of standard samples to create calibration and validation data sets with which to build and validate the models. Parameters such as the root mean square error of calibration (RMSEC), root mean square error of prediction (RMSEP) and correlation coefficient were used to assess the accuracy and linearity of the models. Accurate PLS regression models were created for both co-crystal pairs which can be used to predict the co-crystal concentration in a powder mixture of the co-crystal and the active pharmaceutical ingredient (API). The IBU-NIC model had smaller errors than the CBZ-NIC model, possibly due to the complex CBZ-NIC spectra which could reflect the different arrangement of hydrogen bonding associated with the co-crystal compared to the IBU-NIC co-crystal. These results suggest that NIR spectroscopy can be used as a PAT tool during a variety of pharmaceutical co-crystal manufacturing methods and the presented data will facilitate future offline and in-line NIR studies involving pharmaceutical co-crystals.

  9. Human Neuroma-in-Continuity Contains Focal Deficits in Myelination.

    PubMed

    van Vliet, Arie C; Tannemaat, Martijn R; van Duinen, Sjoerd G; Verhaagen, Joost; Malessy, Martijn J A; De Winter, Fred

    2015-09-01

    Functional recovery does not occur in 10% of patients with neonatal brachial plexus palsy. In these patients, resection of a neuroma-in-continuity (NIC) and surgical nerve reconstruction are required. The formation of a NIC seems to prohibit functional recovery, but the underlying biologic mechanisms for this failure are poorly understood. We systematically analyzed a large series of NIC tissue samples from 17 neonatal and 3 adult patients using an array of immunohistochemical techniques. In a large proportion of patients (74%), the NIC contained multiple focal globular areas with markedly diminished myelination. These focal myelin deficits (FMDs) contain Schwann cells that enwrap axons in an apparently normal configuration but do not form myelin. Biomathematical analysis of a 2-cm neuroma predicted a higher-than-95% probability that an axon would encounter 10 FMDs. Axon segments in FMDs also had disturbed nodes of Ranvier (i.e., FMDs contained significantly fewer clustered Na(v)1.6 channels and decreased Caspr and ankyrin G). These observations indicate that axons in NIC course through multiple FMDs and that this may be the pathobiologic basis for conduction blocks in patients with neonatal brachial plexus palsy. These observations indicate the need for novel strategies to promote functional recovery after neonatal brachial plexus palsy by improving myelination in the NIC.

  10. Core/shell-structured nickel/nitrogen-doped onion-like carbon nanocapsules with improved electromagnetic wave absorption properties

    NASA Astrophysics Data System (ADS)

    Wu, Niandu; Liu, Xianguo; Or, Siu Wing

    2016-05-01

    Core/shell-structured nickel/nitrogen-doped onion-like carbon (Ni/(C, N)) nanocapsules are synthesized by a modified arc-discharge method using N2 gas as the source of N atoms. Core/shell-structured Ni/C nanocapsules are also prepared for comparison. The Ni/(C, N) nanocapsules with diameters of 10-80 nm exhibit a clear core/shell structure. The doping of N atoms introduces more lattice defects into the (C, N) shells and creates more disorderly C in the (C, N) shells. This leads to a slight shift in the dielectric resonance peak to the lower frequency side and an increase in the dielectric loss tangent for the Ni/(C, N) nanocapsules in comparison with the Ni/C nanocapsules. The magnetic permeability of both types of nanocapsules remains almost unaltered since the N atoms exist only in the (C, N) shells. The reflection loss (RL) of the Ni/(C, N) nanocapsules not only reaches a high value of -35 dB at 13.6 GHz, but also is generally improved in the low-frequency S and C microwave bands covering 2-8 GHz as a result of the N-doping-induced additional dipolar polarization and dielectric loss from the (C, N) shells.

  11. Ventilation-perfusion imaging in evaluating regional lung function in nonpenetrating injury to the chest.

    PubMed

    Van Eeden, S F; Klopper, J F; Alheit, B; Bardin, P G

    1989-03-01

    The extent of chest wall and lung injury after nonpenetrating injury to the chest (NIC) determine how aggressive and invasive management modalities should be. We investigated the value of ventilation (133Xe) and perfusion (99mTc) studies as indicators of extent of lung injury in 28 patients with moderate to severe unilateral NIC. The ventilation-perfusion (V/Q) abnormalities were compared with parameters conventionally used to evaluate NIC. All studies were carried out within 24 h of NIC and repeated 24 h later. Ventilation (p less than 0.001) and perfusion (p less than 0.01) abnormalities were more extensive soon after NIC than suggested by chest roentgenograms. Chest x-ray film changes lagged behind V/Q changes on admission and also after 24 h. The extent of ventilation, perfusion, and chest x-ray film abnormalities on admission were all predictors of increased morbidity. V/Q studies may be useful to define the extent as well as the changes in regional lung function following NIC.

  12. Hemodynamic, renal, and humoral effects of the calcium entry blocker nicardipine and converting enzyme inhibitor captopril in hypertensive type II diabetic patients with nephropathy.

    PubMed

    Stornello, M; Valvo, E V; Scapellato, L

    1989-12-01

    We compared the effect of nicardipine, a dihydropiridine derivative calcium entry blocker (CEB), with that of captopril (CAP), a converting-enzyme inhibitor (CEI), and that of the two drugs combined, on blood pressure (BP), heart rate (HR), and renal function in 12 hypertensive type II diabetic outpatients with nephropathy (persistent proteinuria greater than 500 mg/24 h) according to a 2 x 2 factorial design. For 4-week treatments, the patients received nicardipine (NIC) 20 mg t.i.d., CAP 50 mg b.i.d., NIC plus CAP, and matched placebo. Each active treatment significantly reduced BP, with an additive effect of NIC and CAP combined versus either drug alone. HR did not change. Effective renal plasma flow (RPF) and glomerular filtration rate (GRF) were unmodified, but renal vascular resistances (RVRs) were significantly reduced by the three active treatments. Filtration fraction (FF) did not change with NIC or with NIC plus CAP and was significantly reduced with CAP. Urinary albumin excretion (UAE) was significantly reduced by each active treatment to a similar extent. Plasma renin activity (PRA) increased significantly with NIC plus CAP only and did not change when the drugs were administered singly. Plasma aldosterone, glucose, potassium, fructosamine, and urinary sodium and volume did not change during the trial. We conclude that the two drugs singly and combined are useful for treatment of hypertensive non-insulin-dependent diabetes (NIDD) patients with persistent proteinuria.

  13. A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice.

    PubMed

    Abreu-Villaça, Yael; Correa-Santos, Monique; Dutra-Tavares, Ana C; Paes-Branco, Danielle; Nunes-Freitas, Andre; Manhães, Alex C; Filgueiras, Cláudio C; Ribeiro-Carvalho, Anderson

    2016-08-01

    The tobacco industry has gradually decreased nicotine content in cigarette smoke but the impact of this reduction on health is still controversial. Since the central cholinergic system is the primary site of action of nicotine, here, we investigated the effects of exposure of adolescent mice to tobacco smoke containing either high or low levels of nicotine on the central cholinergic system and the effects associated with cessation of exposure. From postnatal day (PN) 30 to 45, male and female Swiss mice were exposed to tobacco smoke (whole body exposure, 8h/day, 7 days/week) generated from 2R1F (HighNic group: 1.74mg nicotine/cigarette) or 4A1 (LowNic group: 0.14mg nicotine/cigarette) research cigarettes, whereas control mice were exposed to ambient air. Cholinergic biomarkers were assessed in the cerebral cortex and midbrain by the end of exposure (PN45), at short- (PN50) and long-term (PN75) deprivation. In the cortex, nicotinic cholinergic receptor upregulation was observed with either type of cigarette. In the midbrain, upregulation was detected only in HighNic mice and remained significant in females at short-term deprivation. The high-affinity choline transporter was reduced in the cortex: of HighNic mice by the end of exposure; of both HighNic and LowNic females at short-term deprivation; of LowNic mice at long-term deprivation. These decrements were separable from effects on choline acetyltransferase and acetylcholinesterase activities, suggesting cholinergic synaptic impairment. Here, we demonstrated central cholinergic alterations in an animal model of tobacco smoke exposure during adolescence. This system was sensitive even to tobacco smoke with very low nicotine content.

  14. NICOTINE METABOLISM IN PREGNANT AND NON-PREGNANT RABBITS

    PubMed Central

    Tutka, Piotr; Dempsey, Delia A.; Jacob, Peyton; Benowitz, Neal L.; Kroetz, Deanna L.

    2010-01-01

    Smoking remains a major public health concern during pregnancy and is associated with numerous adverse effects. Recently the clearance of nicotine (NIC) and cotinine (COT) was shown to be substantially increased in pregnant women compared to non-pregnant controls. The present study investigated the usefulness of the rabbit for studying the molecular basis for the observed changes in NIC and COT disposition during pregnancy. NIC was largely metabolized to COT in rabbit liver microsomes (approximately 50% of total metabolism) with significant amounts of nicotine-N’-oxide and nornicotine also being detected. The conversion of NIC to COT was also detected in rabbit placental and fetal liver microsomes albeit at only a fraction of the rate in adult rabbit liver microsomes. The major products of COT metabolism in rabbit liver microsomes were 5’-hydroxycotinine, cotinine-N’-oxide and norcotinine. Differences between human and rabbit liver were most apparent for COT, with the major human metabolite 3’-hydroxycotinine, being formed at only low levels in rabbit liver microsomes. Pregnancy had no effect on the metabolism of NIC or on the expression of CYP2A6 immunoreactive proteins in rabbit liver microsomes. These studies provide a complete quantitative assessment of NIC metabolism in rabbit liver microsomes and suggest that the rabbit may not be an appropriate animal model to study the effects of pregnancy on NIC and COT metabolism. However, a molecular understanding of these effects is essential for prediction of the pharmacological and toxicological consequences of smoking during pregnancy. PMID:18686186

  15. Wavelet analysis of near-inertial currents at the East Flower Garden Bank

    NASA Astrophysics Data System (ADS)

    Teague, W. J.; Wijesekera, H. W.; Jarosz, E.; Lugo-Fernández, A.; Hallock, Z. R.

    2014-10-01

    Near-inertial currents (NICs) often dominate the mean circulation at the East Flower Garden Bank (EFGB), part of the Flower Garden Banks National Marine Sanctuary. The EFGB, one of several submerged coral reefs, is located in the northwestern Gulf of Mexico, about 190 km southeast of Galveston, Texas. The bank is about 6 km wide in the east-west direction and rises to within about 20 m from the surface. NICs near the EFGB are described using current data from 5 acoustic Doppler current profilers that were moored at the edges of the bank and on top of the bank for about a year. A wavelet analysis was used in order to better describe the nonstationarity of the NICs. NICs were strongest during spring and summer due to their near resonant response with sea breeze and the shallowness of the mixed layer, and exhibited a first-baroclinic-mode vertical structure. NICS were generally larger near the surface and extended to the bottom on the west side of the EFGB but only to within about 20 m of the bottom on the eastern side of the bank. NIC ellipses were nearly circular and rotated clockwise above the top of the EFGB but became flatter and aligned with the bathymetry with increasing depth; occasionally, on the eastern side of the bank, the NIC vectors rotated counterclockwise due to probable effects of lee vortices arising from the mean flow interacting with the bank. Most energy input by the wind at the surface was likely transferred downward through divergence of the meridional flow against the coastal boundary. The inertial currents were at times more energetic than the mean flow, and often accounted for more than 50% of the total current energy.

  16. A ten fold reduction of nicotine yield in tobacco smoke does not spare the central cholinergic system in adolescent mice.

    PubMed

    Abreu-Villaça, Yael; Correa-Santos, Monique; Dutra-Tavares, Ana C; Paes-Branco, Danielle; Nunes-Freitas, Andre; Manhães, Alex C; Filgueiras, Cláudio C; Ribeiro-Carvalho, Anderson

    2016-08-01

    The tobacco industry has gradually decreased nicotine content in cigarette smoke but the impact of this reduction on health is still controversial. Since the central cholinergic system is the primary site of action of nicotine, here, we investigated the effects of exposure of adolescent mice to tobacco smoke containing either high or low levels of nicotine on the central cholinergic system and the effects associated with cessation of exposure. From postnatal day (PN) 30 to 45, male and female Swiss mice were exposed to tobacco smoke (whole body exposure, 8h/day, 7 days/week) generated from 2R1F (HighNic group: 1.74mg nicotine/cigarette) or 4A1 (LowNic group: 0.14mg nicotine/cigarette) research cigarettes, whereas control mice were exposed to ambient air. Cholinergic biomarkers were assessed in the cerebral cortex and midbrain by the end of exposure (PN45), at short- (PN50) and long-term (PN75) deprivation. In the cortex, nicotinic cholinergic receptor upregulation was observed with either type of cigarette. In the midbrain, upregulation was detected only in HighNic mice and remained significant in females at short-term deprivation. The high-affinity choline transporter was reduced in the cortex: of HighNic mice by the end of exposure; of both HighNic and LowNic females at short-term deprivation; of LowNic mice at long-term deprivation. These decrements were separable from effects on choline acetyltransferase and acetylcholinesterase activities, suggesting cholinergic synaptic impairment. Here, we demonstrated central cholinergic alterations in an animal model of tobacco smoke exposure during adolescence. This system was sensitive even to tobacco smoke with very low nicotine content. PMID:27287270

  17. pAO1 of Arthrobacter nicotinovorans and the spread of catabolic traits by horizontal gene transfer in gram-positive soil bacteria.

    PubMed

    Mihasan, Marius; Brandsch, Roderich

    2013-08-01

    The 165-kb megaplasmid pAO1 of Arthrobacter nicotinovorans carries two large gene clusters, one involved in nicotine catabolism (nic-gene cluster) and one in carbohydrate utilization (ch-gene cluster). Here, we propose that both gene clusters were acquired by A. nicotinovorans by horizontal gene transfer mediated by pAO1. Protein-protein blast search showed that none of the published Arthrobacter genomes contains nic-genes, but Rhodococcus opacus carries on its chromosome a nic-gene cluster highly similar to that of pAO1. Analysis of the nic-genes in the two species suggested a recombination event between their nic-gene clusters. Apparently, there was a gene exchange between pAO1, or a precursor plasmid, and a nic-gene cluster of an as yet unidentified Arthrobacter specie or other soil bacterium, possibly related to Rhodococcus, leading to the transfer by pAO1 of this catabolic trait to A. nicotinovorans. Analysis of the pAO1 ch-gene cluster revealed a virtually identical counterpart on the chromosome of Arthrobacter phenanthrenivorans. Moreover, the sequence analysis of the genes flanking the ch-gene cluster suggested that it was acquired by pAO1 by Xer-related site directed recombination and transferred via the plasmid to A. nicotinovorans. The G+C content, the level of sequence identity, gene co-linearity of nic- and ch-gene clusters as well as the signs of recombination events clearly supports the notion of pAO1 and its precursor plasmids as vehicles in HGT among Gram + soil bacteria.

  18. Mild Cognitive Impairment is Associated with Selected Functional Markers: Integrating Concurrent, Longitudinal, and Stability Effects

    PubMed Central

    Dolcos, Sanda; MacDonald, Stuart W.S.; Braslavsky, Anna; Camicioli, Richard; Dixon, Roger A.

    2013-01-01

    Objective We examined functional performance on multiple indicators for two cognitive status groups: (a) not impaired controls (NIC) and (b) mild cognitive impairment (MCI). We identified functional markers associated with differences, changes, and stability in cognitive status. Method In the Victoria Longitudinal Study (VLS) we examined cognitive status group effects in (a) cross-sectional functional performance, (b) longitudinal stability, (c) longitudinal functional performance change, and (d) functional marker prediction of later cognitive status. We assembled markers from five continuous clusters of MCI-related functional factors: biological vitality, activity lifestyle, psychosocial affect, subjective health, and global cognition. We used a cross-sectional sample and a two-wave longitudinal sample, stratified by age (mid-old, old-old) and cognitive status (MCI, NIC). Results First, cross-sectional results showed that eight markers differentiated MCI and NIC adults, with the latter performing uniformly better. The groups differed on diastolic blood pressure, body mass index, positive and negative affect, MMSE, and the lifestyle indicators of self-maintenance, travel, and novel cognitive activities. Second, Wave1 to Wave2 stabilities in cognitive status classification were high. Third, several markers differentiated the stable (NIC-to-NIC, MCI-to-MCI) from the unstable (NIC-to-MCI, MCI-to-NIC) cognitive status groups. Fourth, five relevant markers for identifying older adults at risk for cognitive status changes were: diastolic blood pressure, self-maintenance activities, novel cognitive activities, positive affect, and global cognitive status. Conclusion Selected risk and protective factors differentiate persons classified with MCI from those not currently cognitively impaired, both cross-sectionally and longitudinally. PMID:22251311

  19. [Atypical ganglioglioma with BRAF V600E mutation: a case report and review of the literature].

    PubMed

    Martinez-Ricarte, F; Martinez-Saez, E; Cicuendez, M; Cordero, E; Auger, C; Toledo, M; Radoi, A; Sahuquillo, J

    2016-05-16

    Introduccion. Los gangliogliomas son tumores raros que afectan a pacientes jovenes, aparecen predominantemente en el lobulo temporal y suelen comenzar con crisis epilepticas. Histologicamente corresponden a un grado I de malignidad, con una forma anaplasica catalogada como de grado III en la clasificacion de la Organizacion Mundial de la Salud (OMS) de 2007. Sin embargo, existen tumores que no cumplen criterios de uno u otro grado y que presentan claras diferencias pronosticas respecto a los de grado I. Estos tumores corresponderian a gangliogliomas atipicos (grado II), no contemplados en la citada clasificacion. Desde el punto de vista molecular, la alteracion mas conocida en los gangliogliomas es la mutacion de BRAF V600E, que confiere peor pronostico a la lesion. La posibilidad de utilizar tratamientos dirigidos a esta proteina mutada otorga una especial relevancia a esta alteracion. Caso clinico. Varon de 21 años, intervenido de un ganglioglioma en dos ocasiones, en el que el examen neuropatologico objetivo caracteristicas histologicas compatibles con un grado de malignidad intermedio (grado II) con mutacion positiva a BRAF. Conclusiones. El caso presentado, junto con los descritos previamente en la bibliografia, reabre las controversias sobre la definicion de los gangliogliomas en la clasificacion de la OMS de 2007, y apoya el hecho de que la proxima clasificacion de la OMS deberia volver a incluir los gangliogliomas atipicos (grado II) e integrar posibles mutaciones geneticas y alteraciones moleculares.

  20. Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.

    PubMed

    Varani, Andrés P; Pedrón, Valeria T; Bettler, Bernhard; Balerio, Graciela N

    2014-06-01

    Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC), measured by the elevated plus maze, were abolished by 2-OH-saclofen (GABAB receptor antagonist) (1 mg/kg; ip) or the lack of GABAB receptors (GABAB1 knockout mice). Based on these behavioral data, the aims of the present study were: 1) to evaluate the possible neurochemical changes (dopamine, DA, serotonin, 5-HT, 3,4-dihydroxyphenylacetic acid, DOPAC, 5-hydroxyindoleacetic acid, 5-HIAA and noradrenaline, NA) and the c-Fos expression induced by the anxiolytic (0.05 mg/kg) or anxiogenic (0.8 mg/kg) doses of NIC in the dorsal raphe (DRN) and lateral septal (LSN) nucleus; 2) to study the possible involvement of GABAB receptors on the neurochemical alterations and c-Fos expression induced by NIC (0.05 and 0.8 mg/kg), using both pharmacological (2-OH-saclofen) and genetic (mice GABAB1 knockout) approaches. The results revealed that in wild-type mice, NIC (0.05 mg/kg) increased the concentration of 5-HT and 5-HIAA (p < 0.05) in the DRN, and NIC (0.8 mg/kg) increased the levels of 5-HT (p < 0.01) and NA (p < 0.05) in the LSN. Additionally, 2-OH-saclofen pretreatment (1 mg/kg, ip) or the lack of GABAB receptors abolished these neurochemical changes induced by NIC (p < 0.01, p < 0.05, respectively). On the other hand, NIC 0.05 and 0.8 mg/kg increased (p < 0.01) the c-Fos expression in the DRN and LSN respectively, in wild-type mice. In addition, 2-OH-saclofen pretreatment (1 mg/kg, ip) or the lack of GABAB receptors prevented the c-Fos alterations induced by NIC (p < 0.01). In summary, both approaches show that GABAB receptors would participate in the modulation of anxiolytic- and anxiogenic-like responses induced by NIC, suggesting the potential therapeutic target of these receptors for the tobacco addiction treatment.

  1. Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: a double-blind, placebo-controlled, clinical and EEG/ERP mapping study.

    PubMed

    Saletu, B; Paulus, E; Linzmayer, L; Anderer, P; Semlitsch, H V; Grünberger, J; Wicke, L; Neuhold, A; Podreka, I

    1995-02-01

    In a double-blind, placebo-controlled study on the therapeutic efficacy and central effects of nicergoline, an ergot alkaloid with metabolic, antithrombotic and vasoactive action, 112 patients with mild to moderate dementia, diagnosed according to DSM III-R criteria (MMS 13-25), living in pensioners' homes, were included. Fifty-six were subdiagnosed as senile dementia of the Alzheimer type (SDAT), 56 as multiinfarct dementia (MID), based on computed tomography and Hachinski scores (< or = 49 SDAT, > or = 7 MID). They received, after 2 weeks' run-in period (placebo), randomized for 8 weeks either 2 x 30 mg nicergoline (NIC) or 2 x 1 placebo (PLAC) orally. The four subgroups (SDAT/NIC. SDAT/PLAC, MID/NIC, MID/PLAC; 4 x 28 patients) were comparable in regard to age and sex. Only four, four, four and two patients of the respective groups did not finish the study for minor reasons. Confirmatory statistical analysis demonstrated in the target variable-the Clinical Global Impression (CGI)-a significant superiority of Global Impression (CGI)-a significant superiority of NIC over PLAC in both the SDAT and MID groups. Global improvement (CGI item 2) was seen in both nicergoline subgroups (3 and 3), while no changes occurred under placebo (4 and 4, respectively). The responder versus non-responder ratio was in the SDAT/NIC group 16/8, versus 8/16 in the SDAT/PLAC group (chi 2 = 4.1, P = 0.04); in the MID/NIC group 17/7, versus 7/19 in the MID/PLAC group (chi 2 = 7.96, P < 0.005). Furthermore, there was a significant improvement of the Mini-Mental State and the SCAG score in both the MID and SDAT group after 8 weeks of nicergoline, which was significantly superior to the minimal improvement or no change in placebo-treated SDAT and MID patients. EEG mapping demonstrated in NIC-treated SDAT and MID patients a significant decrease in delta and theta, increase in alpha 2 and beta activity and an acceleration of the centroid of the total power spectrum as compared with pretreatment

  2. Combined effects of marijuana and nicotine on memory performance and hippocampal volume.

    PubMed

    Filbey, Francesca M; McQueeny, Tim; Kadamangudi, Shrinath; Bice, Collette; Ketcherside, Ariel

    2015-10-15

    Combined use of marijuana (MJ) and tobacco is highly prevalent in today's population. Individual use of either substance is linked to structural brain changes and altered cognitive function, especially with consistent reports of hippocampal volume deficits and poorer memory performance. However, the combined effects of MJ and tobacco on hippocampal structure and on learning and memory processes remain unknown. In this study, we examined both the individual and combined effects of MJ and tobacco on hippocampal volumes and memory performance in four groups of adults taken from two larger studies: MJ-only users (n=36), nicotine-only (Nic-only, n=19), combined marijuana and nicotine users (MJ+Nic, n=19) and non-using healthy controls (n=16). Total bilateral hippocampal volumes and memory performance (WMS-III logical memory) were compared across groups controlling for total brain size and recent alcohol use. Results found MJ and MJ+Nic groups had smaller total hippocampal volumes compared to Nic-only and controls. No significant difference between groups was found between immediate and delayed story recall. However, the controls showed a trend for larger hippocampal volumes being associated with better memory scores, while MJ+Nic users showed a unique inversion, whereby smaller hippocampal volume was associated with better memory. Overall, results suggest abnormalities in the brain-behavior relationships underlying memory processes with combined use of marijuana and nicotine use. Further research will need to address these complex interactions between MJ and nicotine. PMID:26187691

  3. THE LINE WIDTH DIFFERENCE OF NEUTRALS AND IONS INDUCED BY MHD TURBULENCE

    SciTech Connect

    Xu, Siyao; Lazarian, A.; Yan, Huirong

    2015-09-01

    We address the problem of the different line widths of coexistent neutrals and ions observed in molecular clouds and explore whether this difference can arise from the effects of magnetohydrodynamic (MHD) turbulence acting on partially ionized gas. Among the three fundamental modes of MHD turbulence, we find that fast and slow modes do not contribute to line width differences. We focus on the Alfvénic component, and consider the damping of Alfvén modes by taking into account both neutral-ion collisions and neutral viscosity. We confirm that the line width difference can be explained by the differential damping of the Alfvénic turbulence in ions and the hydrodynamic turbulence in neutrals, and find it strongly depends on the properties of MHD turbulence. We consider various regimes of turbulence corresponding to different media magnetizations and turbulent drivings. In the case of super-Alfvénic turbulence, when the damping scale of Alfvénic turbulence is below the Alfvénic scale l{sub A}, the line width difference does not depend on magnetic field strength. In other turbulence regimes, however, the dependence is present and evaluation of magnetic field from the observed line width difference is possible.

  4. Nursing interventions in pediatric care: a contribution to measuring workload.

    PubMed

    Assis, Melissa Nardini de; Andrade, Ana Caroline Ramirez de; Rogenski, Karin Emília; Castilho, Valéria; Fugulin, Fernanda Maria Togeiro

    2015-12-01

    Objective To identify and validate interventions/activities developed by a nursing team in a Brazilian pediatric unit. Method A descriptive, cross-sectional, and observational study was developed in the pediatric clinic of the university hospital of University of São Paulo, São Paulo, Brazil. It was organized in the following stages: identifying activities carried out by the team (from records in patient charts and from direct observation); mapping out and validating activities identified in interventions according to the Nursing Intervention Classification (NIC). Results The 275 identified activities were mapped out into 63 interventions, 22 NIC classes and 7 NIC domains, and 25 associated and 13 personal activities. After validation, the number of activities decreased to 244, corresponding to 53 interventions, 20 NIC classes and 6 NIC domains, and 30 associated activities and 9 personal activities. Conclusion Identifying the interventions/activities performed by the nursing team can help measure workload and is an important contribution to overcoming difficulties when it comes to operationalizing the process of sizing professional teams in the field of pediatrics. PMID:26959158

  5. Effects of EOS adiabat on hot spot dynamics

    NASA Astrophysics Data System (ADS)

    Cheng, Baolian; Kwan, Thomas; Wang, Yi-Ming; Batha, Steven

    2013-10-01

    Equation of state (EOS) and adiabat of the pusher play significant roles in the dynamics and formation of the hot spot of an ignition capsule. For given imploding energy, they uniquely determine the partition of internal energy, mass, and volume between the pusher and the hot spot. In this work, we apply the new scaling laws recently derived by Cheng et al. to the National Ignition Campaign (NIC) ignition capsules and study the impacts of EOS and adiabat of the pusher on the hot spot dynamics by using the EOS adiabat index as an adjustable model parameter. We compare our analysis with the NIC data, specifically, for shots N120321 and N120205, and with the numerical simulations of these shots. The predictions from our theoretical model are in good agreements with the NIC data when a hot adiabat was used for the pusher, and with code simulations when a cold adiabat was used for the pusher. Our analysis indicates that the actual adiabat of the pusher in NIC experiments may well be higher than the adiabat assumed in the simulations. This analysis provides a physical and systematic explanation to the ongoing disagreements between the NIC experimental results and the multi-dimensional numerical simulations. This work was performed under the auspices of the U.S. Department of Energy by the Los Alamos National Laboratory under contract number W-7405-ENG-36.

  6. Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization.

    PubMed

    Lee, Hyang-Ae; Hyun, Sung-Ae; Park, Sung-Gurl; Kim, Ki-Suk; Kim, Sung Joon

    2016-01-01

    Dihydropyridine (DHP) calcium channel blockers (CCBs) have been widely used to treat of several cardiovascular diseases. An excessive shortening of action potential duration (APD) due to the reduction of Ca(2+) channel current (I Ca) might increase the risk of arrhythmia. In this study we investigated the electrophysiological effects of nicardipine (NIC), isradipine (ISR), and amlodipine (AML) on the cardiac APD in rabbit Purkinje fibers, voltage-gated K(+) channel currents (I Kr, I Ks) and voltage-gated Na(+) channel current (I Na). The concentration-dependent inhibition of Ca(2+) channel currents (I Ca) was examined in rat cardiomyocytes; these CCBs have similar potency on I Ca channel blocking with IC50 (the half-maximum inhibiting concentration) values of 0.142, 0.229, and 0.227 nM on NIC, ISR, and AML, respectively. However, ISR shortened both APD50 and APD90 already at 1 µM whereas NIC and AML shortened APD50 but not APD90 up to 30 µM. According to ion channel studies, NIC and AML concentration-dependently inhibited I Kr and I Ks while ISR had only partial inhibitory effects (<50% at 30 µM). Inhibition of I Na was similarly observed in the three CCBs. Since the I Kr and I Ks mainly contribute to cardiac repolarization, their inhibition by NIC and AML could compensate for the AP shortening effects due to the block of I Ca.

  7. Simultaneous determination of nicotine, cotinine, and nicotine N-oxide in human plasma, semen, and sperm by LC-Orbitrap MS.

    PubMed

    Abu-Awwad, Ahmad; Arafat, Tawfiq; Schmitz, Oliver J

    2016-09-01

    Nicotine (Nic) distribution in human fluids and tissues has a deleterious effect on human health. In addition to its poisoning profile, Nic may contribute to the particular impact of smoking on human reproduction. Although present in seminal fluid, still nobody knows whether nicotine is available in sperm or not. Herein, we developed and validated a new bioanalytical method, for simultaneous determination of Nic, cotinine (Cot), and nicotine N'-oxide (Nox) in human plasma, semen, and sperm by LC-ESI-orbitrap-MS. Blood and semen samples were collected from 12 healthy smoking volunteers in this study. Sperm bodies were then separated quantitatively from 1 mL of semen samples by centrifugation. The developed method was fully validated for plasma following European and American guidelines for bioanalytical method validation, and partial validation was applied to semen analysis. Plasma, semen, and sperm samples were treated by trichloroacetic acid solution for protein direct precipitation in single extraction step. The established calibration range for Nic and Nox in plasma and semen was linear between 5 and 250 ng/mL, and for Cot between 10 and 500 ng/mL. Nic and Cot were detected in human sperm at concentrations as high as in plasma. In addition, Nox was present in semen and sperm but not in plasma. Graphical abstract Nicotine correlation between plasma and semen a; Nicotine correlation between semen and sperm c; Cotinine correlation between plasma and semen b; Cotinine correlation between semen and sperm d.

  8. Facile Synthesis of Porous Nickel/Carbon Composite Microspheres with Enhanced Electromagnetic Wave Absorption by Magnetic and Dielectric Losses.

    PubMed

    Qiu, Song; Lyu, Hailong; Liu, Jiurong; Liu, Yuzhen; Wu, Nannan; Liu, Wei

    2016-08-10

    Porous nickel/carbon (Ni/C) composite microspheres with diameters of ca. 1.2-1.5 μm were fabricated by a solvothermal method combined with carbon reduction. The pore size of the synthesized Ni/C composite microspheres ranged from several nanometers to 50 nm. The porous Ni/C composite microspheres exhibited a saturation magnetization (MS) of 53.5 emu g(-1) and a coercivity (HC) of 51.4 Oe. When tested as an electromagnetic (EM) wave absorption material, the epoxy resin composites containing 60% and 75% porous Ni/C microspheres provided high-performance EM wave absorption at thicknesses of 3.0-11.0 and 1.6-7.0 mm in the corresponding frequency ranges of 2.0-12 and 2.0-18 GHz, respectively. The superior EM wave absorption performances of porous Ni/C composite microspheres were derived from the synergy effects generated by the magnetic loss of nickel, the dielectric loss of carbon, and the porous structure. PMID:27441382

  9. Combined effects of marijuana and nicotine on memory performance and hippocampal volume.

    PubMed

    Filbey, Francesca M; McQueeny, Tim; Kadamangudi, Shrinath; Bice, Collette; Ketcherside, Ariel

    2015-10-15

    Combined use of marijuana (MJ) and tobacco is highly prevalent in today's population. Individual use of either substance is linked to structural brain changes and altered cognitive function, especially with consistent reports of hippocampal volume deficits and poorer memory performance. However, the combined effects of MJ and tobacco on hippocampal structure and on learning and memory processes remain unknown. In this study, we examined both the individual and combined effects of MJ and tobacco on hippocampal volumes and memory performance in four groups of adults taken from two larger studies: MJ-only users (n=36), nicotine-only (Nic-only, n=19), combined marijuana and nicotine users (MJ+Nic, n=19) and non-using healthy controls (n=16). Total bilateral hippocampal volumes and memory performance (WMS-III logical memory) were compared across groups controlling for total brain size and recent alcohol use. Results found MJ and MJ+Nic groups had smaller total hippocampal volumes compared to Nic-only and controls. No significant difference between groups was found between immediate and delayed story recall. However, the controls showed a trend for larger hippocampal volumes being associated with better memory scores, while MJ+Nic users showed a unique inversion, whereby smaller hippocampal volume was associated with better memory. Overall, results suggest abnormalities in the brain-behavior relationships underlying memory processes with combined use of marijuana and nicotine use. Further research will need to address these complex interactions between MJ and nicotine.

  10. Near-Infrared Camera Calibration for Optical Surgical Navigation.

    PubMed

    Cai, Ken; Yang, Rongqian; Lin, Qinyong; Liu, Sujuan; Chen, Huazhou; Ou, Shanxing; Huang, Wenhua; Zhou, Jing

    2016-03-01

    Near-infrared optical tracking devices, which are important components of surgical navigation systems, need to be calibrated for effective tracking. The calibration results has a direct influence on the tracking accuracy of an entire system. Therefore, the study of calibration techniques is of theoretical significance and practical value. In the present work, a systematic calibration method based on movable plates is established, which analyzes existing calibration theories and implements methods using calibration reference objects. First, the distortion model of near-infrared cameras (NICs) is analyzed in the implementation of this method. Second, the calibration images from different positions and orientations are used to establish the required linear equations. The initial values of the NIC parameters are calculated with the direct linear transformation method. Finally, the accurate internal and external parameters of the NICs are obtained by conducting nonlinear optimization. Analysis results show that the relative errors of the left and right NICs in the tracking system are 0.244 and 0.282 % for the focal lengths and 0.735 and 1.111 % for the principal points, respectively. The image residuals of the left and right image sets are both less than 0.01 pixel. The standard error of the calibration result is lower than 1, and the measurement error of the tracking system is less than 0.3 mm. The experimental data show that the proposed method of calibrating NICs is effective and can generate favorable calibration results. PMID:26728393

  11. Nicotine modulates gelatinase B (MMP-9) and epilysin (MMP-28) expression in reconstituted human oral epithelium.

    PubMed

    Renò, Filippo; Rocchetti, Vincenzo; Migliario, Mario; Cannas, Mario

    2011-01-01

    Oral epithelial keratinocytes express nicotinic cholinergic receptors which activation modulates keratinocytes differentiation and migration through different metabolic pathways. Matrix metalloproteinases (MMPs) are Zn-dependent enzyme involved in cell migration. Among them, gelatinase B (MMP-9) and epilysin (MMP-28) are two MMPs expressed by human keratinocytes during both wound healing and proliferation. Their expression has been investigated in a reconstituted human oral epithelium (HOE) exposed to nicotine (Nic, 1-50 μM) for 72 h both in the absence and presence of the nicotinic antagonist mecamylamine (Mec), H7, a PKC inhibitor and PD98059, a MAPK inhibitor (PD). At the end of treatment, MMP-28 expression has been analyzed in epithelium sections using an anti-MMP-28 antibody, whereas MMP-9 presence and activity has been measured in cell-conditioned medium analyzed by gelatine zymography. The expression of MMP-9 was reduced by Nic in a dose-dependent fashion and this effect was antagonized by Mec, H7 and PD. On the other hand, Nic increased the expression of MMP-28, and this effect was blocked both by H7 and PD, whereas Mec even enforced it. Nic effects on MMP-9 and MMP-28 expression by oral keratinocytes were not previously reported and these data suggest MMPs expression mediated by PKC and MAPK as a possible target for Nic toxicity in oral epithelium.

  12. Nicorandil improves ischemic changes in epicardial ECG during short-term coronary occlusion by opening ATP-sensitive potassium channels in pigs.

    PubMed

    Takaoka, A; Nakae, I; Liu, Q; Yamamoto, K; Ito, M; Kinoshita, M

    1997-12-01

    The aims of this study were to investigate whether nicorandil (NIC), an ATP-sensitive potassium channel (KATP) opener and nitrate, has antiischemic effects during transient ischemia in pigs, and to investigate whether its effects are due to its KATP-opening action or nitrate action. Myocardial ischemia was induced by ligating the proximal portion of the left anterior descending coronary artery for 1 minute in anesthetized open-chest pigs, and was measured as the magnitude of ST-segment elevation on epicardial electrocardiogram (ECG). Epicardial ST-segment elevation during coronary occlusion was significantly reduced by pretreatment with NIC (3 mg, intracoronary [i.c.]), but not by pretreatment with nitroglycerin (NTG, 0.2 mg, i.c.). Pretreatment with glibenclamide (GLB, a KATP blocker, 6 mg, i.c.) significantly augmented the ST-segment elevation during coronary occlusion. The augmentation of ST-segment elevation by GLB was significantly reduced by subsequent administration of NIC, but not by that of NTG (0.2 mg, i.c.). There were no significant differences between hemodynamic variables immediately before coronary occlusion with and without pretreatment. The intracoronary administration of NIC (3 mg) significantly shortened the endocardial monophasic action potential durations at 50% (MAPD50) and 90% repolarization (MAPD90) by 28.3 +/- 6.9% and 17.0 +/- 4.7%, respectively. These results suggest that the intracoronary administration of NIC has antiischemic effects during transient ischemia via KATP activation in myocardium.

  13. Nicotine and carbon monoxide: effects on the isolated rat heart.

    PubMed

    McGrath, J J

    1986-01-01

    We studied the combined effects of carbon monoxide (CO) and nicotine on the performance of the isolated rat heart. Hearts were removed from laboratory rats and perfused through the aorta with 95% O2-5% CO2 (oxygenated) Krebs-Henseleit solution (KHs). After 30 min, the perfusate was switched rapidly to one of three solutions: KHs containing 10% CO-85% O2-5% CO2 (CO), 10 micrograms/ml nicotine (Nic), or CO combined with nicotine (CO + Nic). KHs containing CO increased coronary flow by 41% without affecting heart rate or pulse pressure. Coronary flow returned to control values during recovery in oxygenated KHs. KHs containing Nic decreased heart rate by 20% and coronary flow by 28%. Pulse pressure was unaffected. Both heart rate and coronary flow returned towards control values during recovery in oxygenated KHs. KHs containing CO + Nic decreased heart rate 16% but stimulated coronary flow 13%. Heart rate returned towards control values during recovery; however, coronary flow, which declined to control values after 8 min, continued to decrease during recovery. These results indicate that the separate effects of CO and Nic on coronary flow in the isolated rat heart are opposing and reversible, but that the decrease they produce in combination is irreversible.

  14. PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis.

    PubMed

    Schade, Babette; Rao, Trisha; Dourdin, Nathalie; Lesurf, Robert; Hallett, Michael; Cardiff, Robert D; Muller, William J

    2009-07-10

    Overexpression and/or amplification of the ErbB-2 oncogene as well as inactivation of the PTEN tumor suppressor are two important genetic events in human breast carcinogenesis. To address the biological impact of conditional inactivation of PTEN on ErbB-2-induced mammary tumorigenesis, we generated a novel transgenic mouse model that utilizes the murine mammary tumor virus (MMTV) promoter to directly couple expression of activated ErbB-2 and Cre recombinase to the same mammary epithelial cell (MMTV-NIC). Disruption of PTEN in the mammary epithelium of the MMTV-NIC model system dramatically accelerated the formation of multifocal and highly metastatic mammary tumors, which exhibited homogenous pathology. PTEN-deficient/NIC-induced tumorigenesis was associated with an increase in angiogenesis. Moreover, inactivation of PTEN in the MMTV-NIC mouse model resulted in hyperactivation of the phosphatidylinositol 3'-kinase/Akt signaling pathway. However, like the parental strain, tumors obtained from PTEN-deficient/NIC mice displayed histopathological and molecular features of the luminal subtype of primary human breast cancer. Taken together, our findings provide important implications in understanding the molecular determinants of mammary tumorigenesis driven by PTEN deficiency and ErbB-2 activation and could provide a valuable tool for testing the efficacy of therapeutic strategies that target these critical signaling pathways.

  15. Phosphorus speciation in sequentially extracted agro-industrial by-products: evidence from X-ray absorption near edge structure spectroscopy.

    PubMed

    Kruse, Jens; Negassa, Wakene; Appathurai, Narayana; Zuin, Lucia; Leinweber, Peter

    2010-01-01

    The phosphorus (P) in agro-industrial by-products--a potential source of freshwater eutrophication but also a valuable fertilizer--needs to be speciated to evaluate its fate in the environment. We investigated to what extent X-ray absorption near edge structure (XANES) spectroscopy at the P K- and L2.3-edges reflected differences in sequentially extracted filter cakes from sugarcane (Saccharum officinarum L.) (FIC) and niger seed (Guizotia abyssinica Cass.; NIC) processing industry in Ethiopia. The P fractionation removed more labile (54%) and H2SO4-P (28%) from FIC than from NIC (18% labile, 12% H2SO4-P). For the FIC residues after each extraction step, linear combination (LC) fitting of P K-edge spectra provided evidence for the enrichment of Ca-P after the NaOH-extraction and its almost complete removal after the H2SO4-treatment. The LC-fitting was unsuccessful for the NIC samples, likely because of the predominance of organic P compounds. The different proportions of Ca-P compounds between FIC (large) and NIC (small) were more distinctive in L2-than in the K-edge XANES spectra. In conclusion, the added value of complementary P K- and L2.3-edge XANES was clearly demonstrated, and the P fractionation and speciation results together justify using FIC and NIC as soil amendments in the tropics.

  16. Comparison of electrophysiological effects of calcium channel blockers on cardiac repolarization

    PubMed Central

    Lee, Hyang-Ae; Hyun, Sung-Ae; Park, Sung-Gurl

    2016-01-01

    Dihydropyridine (DHP) calcium channel blockers (CCBs) have been widely used to treat of several cardiovascular diseases. An excessive shortening of action potential duration (APD) due to the reduction of Ca2+ channel current (ICa) might increase the risk of arrhythmia. In this study we investigated the electrophysiological effects of nicardipine (NIC), isradipine (ISR), and amlodipine (AML) on the cardiac APD in rabbit Purkinje fibers, voltage-gated K+ channel currents (IKr, IKs) and voltage-gated Na+ channel current (INa). The concentration-dependent inhibition of Ca2+ channel currents (ICa) was examined in rat cardiomyocytes; these CCBs have similar potency on ICa channel blocking with IC50 (the half-maximum inhibiting concentration) values of 0.142, 0.229, and 0.227 nM on NIC, ISR, and AML, respectively. However, ISR shortened both APD50 and APD90 already at 1 µM whereas NIC and AML shortened APD50 but not APD90 up to 30 µM. According to ion channel studies, NIC and AML concentration-dependently inhibited IKr and IKs while ISR had only partial inhibitory effects (<50% at 30 µM). Inhibition of INa was similarly observed in the three CCBs. Since the IKr and IKs mainly contribute to cardiac repolarization, their inhibition by NIC and AML could compensate for the AP shortening effects due to the block of ICa. PMID:26807031

  17. Zonation of the Newry Igneous Complex, Northern Ireland, based on geochemical and geophysical data

    NASA Astrophysics Data System (ADS)

    Anderson, P. E.; Cooper, M. R.; Stevenson, C. T.; Hastie, A. R.; Hoggett, M.; Inman, J.; Meighan, I. G.; Hurley, C.; Reavy, R. J.; Ellam, R. M.

    2016-09-01

    The Late Caledonian Newry Igneous Complex (NIC), Northern Ireland, comprises three largely granodioritic plutons, together with an intermediate-ultramafic body at its northeastern end. New whole-rock geochemical data, petrological classifications, and published data, including recent Tellus aeromagnetic and radiometric results, have been used to establish 15 distinct zones across the four bodies of the NIC. These become broadly younger to the southwest of the complex and toward the centres of individual plutons. In places, zones are defined by both current compositional data (geochemistry and petrology) and Tellus results. This is particularly clear at the eastern edge of the NIC, where a thorium-elevated airborne radiometric signature occurs alongside distinct concentrations of various elements from geochemistry. However, in the northeastern-most pluton of the NIC, a prominent ring-shaped aeromagnetic anomaly occurs independent of any observed surface compositional variation, and thus the zones in this area are defined by aeromagnetic data only. The origins of this and other aeromagnetic anomalies are as yet undetermined, although in places, these closely correspond to facies at the surface. The derived zonation for the NIC supports incremental emplacement of the complex as separate, distinct magma pulses. Each pulse is thought to have originated from the same fractionally crystallising source that periodically underwent mixing with more basic magma.

  18. Combined Effects of Marijuana and Nicotine on Memory Performance and Hippocampal Volume

    PubMed Central

    Filbey, Francesca M.; McQueeny, Tim; Kadamangudi, Shrinath; Bice, Collette; Ketcherside, Ariel

    2015-01-01

    Combined use of marijuana (MJ) and tobacco is highly prevalent in today's population. Individual use of either substance is linked to structural brain changes and altered cognitive function, especially with consistent reports of hippocampal volume deficits and poorer memory performance. However, the combined effects of MJ and tobacco on hippocampal structure and on learning and memory processes remain unknown. In this study, we examined both the individual and combined effects of MJ and tobacco on hippocampal volumes and memory performance in four groups of adults taken from two larger studies: MJ-only users (n=36), nicotine-only (Nic-only, n=19), combined marijuana and nicotine users (MJ+Nic, n=19) and non-using healthy controls (n=16). Total bilateral hippocampal volumes and memory performance (WMS-III logical memory) were compared across groups controlling for total brain size and recent alcohol use. Results found MJ and MJ+Nic groups had smaller total hippocampal volumes compared to Nic-only and controls. No significant difference between groups was found between immediate and delayed story recall. However, the controls showed a trend for larger hippocampal volumes being associated with better memory scores, while MJ+Nic users showed a unique inversion, whereby smaller hippocampal volume was associated with better memory. Overall, results suggest abnormalities in the brain-behavior relationships underlying memory processes with combined use of marijuana and nicotine use. Further research will need to address these complex interactions between MJ and nicotine. PMID:26187691

  19. Facile Synthesis of Porous Nickel/Carbon Composite Microspheres with Enhanced Electromagnetic Wave Absorption by Magnetic and Dielectric Losses.

    PubMed

    Qiu, Song; Lyu, Hailong; Liu, Jiurong; Liu, Yuzhen; Wu, Nannan; Liu, Wei

    2016-08-10

    Porous nickel/carbon (Ni/C) composite microspheres with diameters of ca. 1.2-1.5 μm were fabricated by a solvothermal method combined with carbon reduction. The pore size of the synthesized Ni/C composite microspheres ranged from several nanometers to 50 nm. The porous Ni/C composite microspheres exhibited a saturation magnetization (MS) of 53.5 emu g(-1) and a coercivity (HC) of 51.4 Oe. When tested as an electromagnetic (EM) wave absorption material, the epoxy resin composites containing 60% and 75% porous Ni/C microspheres provided high-performance EM wave absorption at thicknesses of 3.0-11.0 and 1.6-7.0 mm in the corresponding frequency ranges of 2.0-12 and 2.0-18 GHz, respectively. The superior EM wave absorption performances of porous Ni/C composite microspheres were derived from the synergy effects generated by the magnetic loss of nickel, the dielectric loss of carbon, and the porous structure.

  20. Simultaneous determination of nicotine, cotinine, and nicotine N-oxide in human plasma, semen, and sperm by LC-Orbitrap MS.

    PubMed

    Abu-Awwad, Ahmad; Arafat, Tawfiq; Schmitz, Oliver J

    2016-09-01

    Nicotine (Nic) distribution in human fluids and tissues has a deleterious effect on human health. In addition to its poisoning profile, Nic may contribute to the particular impact of smoking on human reproduction. Although present in seminal fluid, still nobody knows whether nicotine is available in sperm or not. Herein, we developed and validated a new bioanalytical method, for simultaneous determination of Nic, cotinine (Cot), and nicotine N'-oxide (Nox) in human plasma, semen, and sperm by LC-ESI-orbitrap-MS. Blood and semen samples were collected from 12 healthy smoking volunteers in this study. Sperm bodies were then separated quantitatively from 1 mL of semen samples by centrifugation. The developed method was fully validated for plasma following European and American guidelines for bioanalytical method validation, and partial validation was applied to semen analysis. Plasma, semen, and sperm samples were treated by trichloroacetic acid solution for protein direct precipitation in single extraction step. The established calibration range for Nic and Nox in plasma and semen was linear between 5 and 250 ng/mL, and for Cot between 10 and 500 ng/mL. Nic and Cot were detected in human sperm at concentrations as high as in plasma. In addition, Nox was present in semen and sperm but not in plasma. Graphical abstract Nicotine correlation between plasma and semen a; Nicotine correlation between semen and sperm c; Cotinine correlation between plasma and semen b; Cotinine correlation between semen and sperm d. PMID:27422648

  1. Celecoxib:Nicotinamide Dissociation: Using Excipients to Capture the Cocrystal's Potential

    SciTech Connect

    Remenar,J.; Peterson, M.; Stephens, P.; Zhang, Z.; Zimenkov, Y.; Hickey, M.

    2007-01-01

    The cocrystal of celecoxib and nicotinamide (Cel:Nic) was crystallized from chloroform in a 1:1 ratio, and the structure has been solved from powder X-ray diffraction data. The dissolution and solubility of Cel:Nic are medium dependent and can be attributed to differences in conversion of Cel:Nic to celecoxib polymorphs I and III (Cel-I and Cel-III). The presence of low concentrations of surfactants facilitates the rapid conversion of neat Cel:Nic to large aggregates of Cel-III that dissolve more slowly than commercial Cel-III into 1% SDS solution. In contrast, combinations of Cel:Nic with both 1-10% solid SDS and PVP wet rapidly and convert to a mixture of amorphous celecoxib and a micron-sized crystalline celecoxib form IV (Cel-IV), which has recently been shown to be up to 4-fold more bioavailable than marketed Cel-III. More than 90% of the suspended material dissolves within 2 min at 37 C when transferred to 1% SDS solution. This example highlights the importance of exploring the form conversion of cocrystals in aqueous media prior to pharmacokinetic studies, and illustrates the potential of simple formulations to overcome the limitations caused by rapid dissociation of cocrystals and recrystallization of poorly soluble forms in aqueous media.

  2. Celecoxib: Nicotinamide Dissociateion: Using Excipients to Capture the Cocrystal's Potential

    SciTech Connect

    Remenar,J.; Peterson, M.; Stephens, P.; Zhang, Z.; Zimenkov, Y.; Hickey, M.

    2007-01-01

    The cocrystal of celecoxib and nicotinamide (Cel:Nic) was crystallized from chloroform in a 1:1 ratio, and the structure has been solved from powder X-ray diffraction data. The dissolution and solubility of Cel:Nic are medium dependent and can be attributed to differences in conversion of Cel:Nic to celecoxib polymorphs I and III (Cel-I and Cel-III). The presence of low concentrations of surfactants facilitates the rapid conversion of neat Cel:Nic to large aggregates of Cel-III that dissolve more slowly than commercial Cel-III into 1% SDS solution. In contrast, combinations of Cel:Nic with both 1-10% solid SDS and PVP wet rapidly and convert to a mixture of amorphous celecoxib and a micron-sized crystalline celecoxib form IV (Cel-IV), which has recently been shown to be up to 4-fold more bioavailable than marketed Cel-III. More than 90% of the suspended material dissolves within 2 min at 37 C when transferred to 1% SDS solution. This example highlights the importance of exploring the form conversion of cocrystals in aqueous media prior to pharmacokinetic studies, and illustrates the potential of simple formulations to overcome the limitations caused by rapid dissociation of cocrystals and recrystallization of poorly soluble forms in aqueous media.

  3. LETTER TO THE EDITOR: Specific heat and linear birefringence behaviour of 4-aminopyridinium tetrachloroantimonate (III), [4-NH2C5H4NH][SbCl4

    NASA Astrophysics Data System (ADS)

    Przeslawski, J.; Kosturek, B.; Jakubas, R.

    2003-11-01

    Thermal (specific heat) and optical (linear birefringence) studies were performed for a new ferroelectric crystal [4-NH2C5H4NH][SbCl4]. Four phase transitions were confirmed and described. Thermal parameters (DgrH,DgrS) of the normal-incommensurate, N-IC, and incommensurate-ferroelectric commensurate, IC-F(C), phase transitions are given. The order-disorder mechanism of the N-IC phase transition is proved but the displacive one for the IC-F(C) transition can be proposed. The critical index value (2bgr = 0.68 ± 0.02) estimated from the linear birefringence measurements indicates that the N-IC phase transition can be described in terms of the 3d XY model.

  4. Modeling the Nearly Isotropic Comet Population in Anticipation of LSST Observations

    NASA Astrophysics Data System (ADS)

    Silsbee, Kedron; Tremaine, Scott

    2016-10-01

    We run simulations to determine the expected distribution of orbital elements of nearly isotropic comets (NICs) in the outer solar system, assuming that these comets originate in the Oort Cloud at thousands of au and are perturbed into the planetary region by the Galactic tide. We show that the Large Synoptic Survey Telescope should detect and characterize the orbits of hundreds to thousands of NICs with perihelion distance outside 5 au. Observing NICs in the outer solar system is our only way of directly detecting comets from the inner Oort Cloud, as these comets are dynamically excluded from the inner solar system by the giant planets. Thus, the distribution of orbital elements constrains the spatial distribution of comets in the Oort Cloud and the environment in which the solar system formed. Additionally, comet orbits can be characterized more precisely when they are seen far from the Sun as they have not been affected by nongravitational forces.

  5. NICMOS focus monitor

    NASA Astrophysics Data System (ADS)

    Schneider, Glenn

    1997-07-01

    This proposal is used to determine and monitor the optimal focus and tilt settings for all three NICMOS cameras. It is derived from SM2/NIC 7041, but is structurally quite a bit different. This proposal is built to run NIC1/2 focus sweeps on a weekly basis, and NIC3 focus sweeps twice a week during SMOV {following the "interim" runs of the 7150}. 7043 will run for as long as it is deemed necessary to keep track of the camera focii and to monitor the dewar anomaly. After the discussion on 20/3/96, this proposal is written to run 4 complete 1-week iterations starting 3 days after the last run of the 7150 {NICMOS COARSE OPTICAL ALIGNMENT, PART 2}.

  6. The generation of myricetin–nicotinamide nanococrystals by top down and bottom up technologies

    NASA Astrophysics Data System (ADS)

    Liu, Mingyu; Hong, Chao; Li, Guowen; Ma, Ping; Xie, Yan

    2016-09-01

    Myricetin–nicotinamide (MYR–NIC) nanococrystal preparation methods were developed and optimized using both top down and bottom up approaches. The grinding (top down) method successfully achieved nanococrystals, but there were some micrometer range particles and aggregation. The key consideration of the grinding technology was to control the milling time to determine a balance between the particle size and distribution. In contrast, a modified bottom up approach based on a solution method in conjunction with sonochemistry resulted in a uniform MYR–NIC nanococrystal that was confirmed by powder x-ray diffraction, scanning electron microscopy, dynamic light scattering, and differential scanning calorimeter, and the particle dissolution rate and amount were significantly greater than that of MYR–NIC cocrystal. Notably, this was a simple method without the addition of any non-solvent. We anticipate our findings will provide some guidance for future nanococrystal preparation as well as its application in both chemical and pharmaceutical area.

  7. Neutron Imaging Camera

    NASA Technical Reports Server (NTRS)

    Hunter, Stanley D.; DeNolfo, Georgia; Floyd, Sam; Krizmanic, John; Link, Jason; Son, Seunghee; Guardala, Noel; Skopec, Marlene; Stark, Robert

    2008-01-01

    We describe the Neutron Imaging Camera (NIC) being developed for DTRA applications by NASA/GSFC and NSWC/Carderock. The NIC is based on the Three-dimensional Track Imager (3-DTI) technology developed at GSFC for gamma-ray astrophysics applications. The 3-DTI, a large volume time-projection chamber, provides accurate, approximately 0.4 mm resolution. 3-D tracking of charged particles. The incident direction of fast neutrons, E(sub N) > 0.5 MeV. arc reconstructed from the momenta and energies of the proton and triton fragments resulting from 3He(n,p)3H interactions in the 3-DTI volume. We present angular and energy resolution performance of the NIC derived from accelerator tests.

  8. The generation of myricetin-nicotinamide nanococrystals by top down and bottom up technologies

    NASA Astrophysics Data System (ADS)

    Liu, Mingyu; Hong, Chao; Li, Guowen; Ma, Ping; Xie, Yan

    2016-09-01

    Myricetin-nicotinamide (MYR-NIC) nanococrystal preparation methods were developed and optimized using both top down and bottom up approaches. The grinding (top down) method successfully achieved nanococrystals, but there were some micrometer range particles and aggregation. The key consideration of the grinding technology was to control the milling time to determine a balance between the particle size and distribution. In contrast, a modified bottom up approach based on a solution method in conjunction with sonochemistry resulted in a uniform MYR-NIC nanococrystal that was confirmed by powder x-ray diffraction, scanning electron microscopy, dynamic light scattering, and differential scanning calorimeter, and the particle dissolution rate and amount were significantly greater than that of MYR-NIC cocrystal. Notably, this was a simple method without the addition of any non-solvent. We anticipate our findings will provide some guidance for future nanococrystal preparation as well as its application in both chemical and pharmaceutical area.

  9. Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast.

    PubMed

    Bozdag, Gonensin O; Kaya, Alaattin; Koc, Ahmet; Noll, Gundula A; Prüfer, Dirk; Karakaya, Hüseyin Caglar

    2014-04-01

    Nickel is an essential micronutrient due to its involvement in many enzymatic reactions as a cofactor. However, excess of this element is toxic to biological systems. Here, we constructed a cDNA library from Beta maritima and screened it in the yeast system to identify genes that confer resistance to toxic levels of nickel. A cDNA clone (NIC6), which encodes for a putative membrane protein with unknown function, was found to help yeast cells to tolerate toxic levels of nickel. A GFP fused form of Nic6 protein was localized to multivesicular structures in tobacco epidermal cells. Thus, our results suggest a possible role of Nic6 in nickel and intracellular ion homeostasis.

  10. Theoretical study of nascent solvation in Ni+ (benzene)m, m = 3 and 4, clusters.

    PubMed

    Castro, Miguel; Flores, Raul; Duncan, Michael A

    2013-11-27

    The ligand versus solvent behavior of Ni(+)(C6H6)3,4 complexes was studied using density functional theory all-electron calculations. Dispersion corrections were included with the BPW91-D2 method using the 6-311++G(2d,2p) basis set. The ground state (GS) for Ni(+)(C6H6)3 has three benzene rings 3d-π bonded to the metal. A two-layer isomer with two moieties coordinated η(3)-η(2) with Ni(+), and the other one adsorbed by van der Waals interactions to the Ni(+)(C6H6)2 subcluster, i.e., a 2 + 1 structure, is within about 8.4 kJ/mol of the GS. Structures with 3 + 1 and 2 + 2 ligand coordination were found for Ni(+)(C6H6)4. The binding energies (D0) of 28.9 and 26.0 kJ/mol for the external moieties of Ni(+)(C6H6)3,4 are much smaller than that for Ni(+)(C6H6)2, 193.0 kJ/mol, obtained also with BPW91-D2. This last D0 overestimates somehow the experimental value, of 146.7 ± 11.6 kJ/mol, for Ni(+)(C6H6)2. The abrupt fall for D0(Ni(+)(C6H6)3,4) shows that such molecules are bound externally as solvent species. These results agree with the D0(Ni(+)(C6H6)3) < 37.1 kJ/mol limit found experimentally for this kind of two-layer clusters. The ionization energies also decrease for m = 2, 3, and 4 (580.8, 573.1, and 558.6 kJ/mol). For Ni(+)(C6H6)3,4, each solvent moiety bridges the benzenes of Ni(+)(C6H6)2; their position and that of one internal ring mimics the tilted T-shape geometry of the benzene dimer (Bz2). The distances from the center of the external to the center of the internal rings for m = 3 (4.686 Å) and m = 4 (4.523 Å) are shorter than that for Bz2 (4.850 Å). This and charge transfer effects promote the (C(δ-)-H(δ+))(int) dipole-π(ext) interactions in Ni(+)(C6H6)3,4; π-π interactions also occur. The predicted IR spectra, having multiplet structure in the C-H region, provide insight into the experimental spectra of these ions. PMID:24218987

  11. Architecture of the fungal nuclear pore inner ring complex.

    PubMed

    Stuwe, Tobias; Bley, Christopher J; Thierbach, Karsten; Petrovic, Stefan; Schilbach, Sandra; Mayo, Daniel J; Perriches, Thibaud; Rundlet, Emily J; Jeon, Young E; Collins, Leslie N; Huber, Ferdinand M; Lin, Daniel H; Paduch, Marcin; Koide, Akiko; Lu, Vincent; Fischer, Jessica; Hurt, Ed; Koide, Shohei; Kossiakoff, Anthony A; Hoelz, André

    2015-10-01

    The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of the ~425-kilodalton inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1•Nup49•Nup57 channel nucleoporin heterotrimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT•Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three-dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. We propose that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation.

  12. The generation of myricetin-nicotinamide nanococrystals by top down and bottom up technologies.

    PubMed

    Liu, Mingyu; Hong, Chao; Li, Guowen; Ma, Ping; Xie, Yan

    2016-09-30

    Myricetin-nicotinamide (MYR-NIC) nanococrystal preparation methods were developed and optimized using both top down and bottom up approaches. The grinding (top down) method successfully achieved nanococrystals, but there were some micrometer range particles and aggregation. The key consideration of the grinding technology was to control the milling time to determine a balance between the particle size and distribution. In contrast, a modified bottom up approach based on a solution method in conjunction with sonochemistry resulted in a uniform MYR-NIC nanococrystal that was confirmed by powder x-ray diffraction, scanning electron microscopy, dynamic light scattering, and differential scanning calorimeter, and the particle dissolution rate and amount were significantly greater than that of MYR-NIC cocrystal. Notably, this was a simple method without the addition of any non-solvent. We anticipate our findings will provide some guidance for future nanococrystal preparation as well as its application in both chemical and pharmaceutical area. PMID:27535365

  13. First-principle study of structure and stability of nickel carbides.

    PubMed

    Gibson, Josh S; Uddin, Jamal; Cundari, Thomas R; Bodiford, Nelli K; Wilson, Angela K

    2010-11-10

    Computational studies of nickel carbides, particularly Ni(2)C, are scarce. A systematic density functional theory study is reported for Ni(2)C, along with NiC and Ni(3)C, to understand the stability and electronic structure of nickel carbides of varying stoichiometry. A comprehensive study was executed that involved 28 trial structures of varying space group symmetry for Ni(2)C. An analysis of the electronic structure, geometry and thermodynamics of Ni(2)C is performed, and compared with that for Ni(3)C and NiC as well as several defect structures of varying composition. It is found that the most stable ground state arrangement of Ni(2)C exists within a simple orthorhombic lattice and that it has metallic character. The calculated formation energies (kcal mol(-1)) of NiC, Ni(2)C, and Ni(3)C are 48.6, 7.9 and 6.4, respectively.

  14. [Correspondence among care prescriptions for patients with orthopedic problems and the Nursing Interventions Classification].

    PubMed

    Almeida, Miriam de Abreu; Longaray, Vanessa Kenne; De Cezaro, Paula; Barilli, Sofia Louise Santin

    2007-12-01

    The objective of this work was to compare the care prescribed by nurses for orthopedic surgery patients after surgery with the interventions and activities proposed by the Nursing Interventions Classification (NIC), in order to verify its agreement. The study was carried out at the Hospital de Clinicas de Porto Alegre (a University hospital in the south of Brazil), using the mapping technique. Data on the 170 studied patients were obtained by the Computerized Nursing Prescription System. The 52 care forms related to nursing diagnosis (ND) Self-Care Deficit--bath and/or hygiene, Impaired Physical Mobility and Risk of Infection--were mapped with 33 nursing interventions, contained in 14 classes and 4 Domains. The comparison between nursing prescriptions and the interventions proposed by the NIC for the 3 ND studied evidenced there is agreement among them. We considered that the NIC may become an important source of consultation to improve and to base nursing care.

  15. Pulsed Plasma Synthesis of Iron and Nickel Nanoparticles Coated by Carbon for Medical Applications

    NASA Astrophysics Data System (ADS)

    Abdullaeva, Zhypargul; Omurzak, Emil; Iwamoto, Chihiro; Ihara, Hirotaka; Subban Ganapathy, Hullathy; Sulaimankulova, Saadat; Koinuma, Michio; Mashimo, Tsutomu

    2013-01-01

    Fe and Ni magnetic nanoparticles coated by carbon were synthesized between the Fe-Fe and Ni-Ni metal electrodes, submerged in ethanol using pulsed plasma in a liquid method. Iron coated carbon (Fe@C) nanoparticles have an average size of 32 nm, and Ni@C nanoparticles are 40 nm. Obtained samples exhibit a well-defined crystalline structure of the inner Fe and Ni cores, encapsulated in the graphitic carbon coatings. Cytotoxicity studies performed on the MCF-7 (breast cancer) cell line showed small toxicity about 88-74% at 50 µg/mL of Fe@C and Ni@C nanoparticles, which can be significant criteria for use them in medical cancer treatment. In addition, appropriate sizes, good magnetic properties and well-organized graphitic carbon coatings are highlight merits of Fe@C and Ni@C nanoparticles synthesized by pulsed plasma.

  16. Creating and validating an instrument to identify the workload at an oncology and hematology outpatient service

    PubMed Central

    Martin, Lelia Gonçalves Rocha; Gaidzinski, Raquel Rapone

    2014-01-01

    Objective Construct and to validate an instrument for measuring the time spent by nursing staff in the interventions/activities in Outpatient Oncology and Hematology, interventions based on Nursing Interventions Classification (NIC), for key areas of Pediatric Oncology and Oncology Nursing. Methods Cross-sectional study divided into two steps: (1) construction of an instrument to measure the interventions/Nursing activities and (2) validation of this instrument. Results We selected 32 essential interventions from NIC for Pediatric Oncology and Oncology Nursing areas. The judges agreed with removing 13 and including 6 interventions in the instrument, beyond personal activity. Conclusion The choice of essential interventions from NIC is justified by the gain time on research. PMID:25295454

  17. Neonatal Nicotine Exposure Leads to Hypothalamic Gliosis in Adult Overweight Rats.

    PubMed

    Younes-Rapozo, V; Moura, E G; Manhães, A C; Pinheiro, C R; Carvalho, J C; Barradas, P C; de Oliveira, E; Lisboa, P C

    2015-12-01

    Astrocytes and microglia, the immune competent cells of central nercous system, can be activated in response to metabolic signals such as obesity and hyperleptinaemia. In rats, maternal exposure to nicotine during lactation leads to central obesity, hyperleptinaemia, leptin resistance and alterations in hypothalamic neuropeptides in the offspring during adulthood. In the present study, we studied the activation of astrocytes and microglia, as well as the pattern of inflammatory mediators, in adult offspring of this experimental model. On postnatal day 2 (P2), osmotic minipumps releasing nicotine (NIC) (-6 mg/kg/day) or saline for 14 days were s.c. implanted in dams. Male offspring were killed on P180 and hypothalamic immunohistochemistry, retroperitoneal white adipose tissue (WAT) polymerase chain reaction analysis and multiplex analysis for plasma inflammatory mediators were carried out. At P180, NIC astrocyte cell number was higher in the arcuate nucleus (ARC) (medial: +82%; lateral: +110%), in the paraventricular nucleus (PVN) (+144%) and in the lateral hypothalamus (+121%). NIC glial fibrillary acidic protein fibre density was higher in the lateral ARC (+178%) and in the PVN (+183%). Interleukin-6 was not affected in the hypothalamus. NIC monocyte chemotactic protein 1 was only higher in the periventricular nucleus (+287%). NIC microglia (iba-1-positive) cell number was higher (+68%) only in the PVN, as was the chemokine (C-X3-C motif) receptor 1 density (+93%). NIC interleukin-10 was lower in the WAT (-58%) and plasma (-50%). Thus, offspring of mothers exposed to nicotine during lactation present hypothalamic astrogliosis at adulthood and microgliosis in the PVN.

  18. Description of a new non-injectable connector to reduce the complications of arterial blood sampling.

    PubMed

    Mariyaselvam, M Z; Heij, R E; Laba, D; Richardson, J A; Hodges, E J; Maduakor, C A; Carter, J J; Young, P J

    2015-01-01

    Arterial cannulation is associated with complications including bacterial contamination, accidental intra-arterial injection and blood spillage. We performed a series of audits and experiments to gauge the potential for these, as well as assess the possible contribution of a new device, the Needle-Free Arterial Non-Injectable Connector (NIC), in reducing these risks. The NIC comprises a needle-free connector that prevents blood spillage and a one-way valve allowing aspiration only; once screwed onto the side port of a three-way tap, the device can only be removed with difficulty. We performed a clinical audit of arterial monitoring systems in our intensive care unit, which showed an incidence of bacterial colonisation of five in 86 (6%) three-way tap ports. We constructed a manikin simulation experiment of the management of acute bradycardia, in which trainee doctors were required to inject atropine intravenously. Ten of 15 (66%) doctors injected the drug into the three-way tap of the arterial monitoring system rather than into the intravenous cannula or the central venous catheter. In a laboratory study, we replicated the arterial blood sampling and flushing sequence from a three-way tap, with the syringes attached either directly to the three-way tap port or to a NIC attached to the port. The first (discard) syringe attached to the three-way tap was contaminated with bacteria. Bacterial growth was found in 17 of 20 (85%) downstream flushed samples (corresponding to the patient's circulation) when the three-way tap was accessed directly, compared to none of 20 accessed via the NIC (p < 0.0001). Growth was found on all of 20 (100%) ports accessed directly compared to none of 20 accessed via the NIC (p < 0.0001). The NIC effectively prevents bacteria from contaminating sampling lines. As its design also prevents accidental intra-arterial injection, we suggest that it can reduce complications of arterial monitoring.

  19. Neuroanatomical circuitry mediating the sensory impact of nicotine in the central nervous system.

    PubMed

    Dehkordi, Ozra; Rose, Jed E; Asadi, Sadegh; Manaye, Kebreten F; Millis, Richard M; Jayam-Trouth, Annapurni

    2015-02-01

    Direct actions of nicotine in the CNS appear to be essential for its reinforcing properties. However, activation of nicotinic acetylcholine receptors (nAChRs) on afferent sensory nerve fibers is an important component of addiction to, and withdrawal from, cigarette smoking. The aim of the present study was to identify the neuroanatomical substrates activated by the peripheral actions of nicotine and to determine whether these sites overlap brain structures stimulated by direct actions of nicotine. Mouse brains were examined by immunohistochemistry for c-Fos protein after intraperitoneal injection of either nicotine hydrogen tartrate salt (NIC; 30 and 40 μg/kg) or nicotine pyrrolidine methiodide (NIC-PM; 20 and 30 μg/kg). NIC-PM induced c-Fos immunoreactivity (IR) at multiple brain sites. In the brainstem, c-Fos IR was detected in the locus coeruleus, laterodorsal tegmental nucleus, and pedunculotegmental nucleus. In the midbrain, c-Fos IR was observed in areas overlapping the ventral tegmental area (VTA), which includes the paranigral nucleus, parainterfascicular nucleus, parabrachial pigmental area, and rostral VTA. Other structures of the nicotine brain-reward circuitry activated by NIC-PM included the hypothalamus, paraventricular thalamic nucleus, lateral habenular nucleus, hippocampus, amygdala, accumbens nucleus, piriform cortex, angular insular cortex, anterior olfactory nucleus, lateral septal nucleus, bed nucleus of stria terminalis, cingulate and medial prefrontal cortex, olfactory tubercle, and medial and lateral orbital cortex. NIC, acting through central and peripheral nAChRs, produced c-Fos IR in areas that overlapped NIC-PM-induced c-Fos-expressing sites. These neuroanatomical data are the first to demonstrate that the CNS structures that are the direct targets of nicotine are also anatomical substrates for the peripheral sensory impact of nicotine.

  20. The pro-oxidant gene p66shc increases nicotine exposure-induced lipotoxic oxidative stress in renal proximal tubule cells.

    PubMed

    Arany, Istvan; Hall, Samuel; Reed, Dustin K; Dixit, Mehul

    2016-09-01

    Nicotine (NIC) exposure augments free fatty acid (FFA) deposition and oxidative stress, with a concomitant increase in the expression of the pro-oxidant p66shc. In addition, a decrease in the antioxidant manganese superoxide dismutase (MnSOD) has been observed in the kidneys of mice fed a high‑fat diet. The present study aimed to determine whether the pro‑oxidant p66shc mediates NIC‑dependent increases in renal oxidative stress by augmenting the production of reactive oxygen species (ROS) and suppressing the FFA‑induced antioxidant response in cultured NRK52E renal proximal tubule cells. Briefly, NRK52E renal proximal tubule cells were treated with 200 µM NIC, 100 µM oleic acid (OA), or a combination of NIC and OA. The expression levels of p66shc and MnSOD were modulated according to genetic methods. ROS production and cell injury, in the form of lactate dehydrogenase release, were subsequently detected. Promoter activity of p66shc and MnSOD, as well as forkhead box (FOXO)‑dependent transcription, was investigated using reporter luciferase assays. The results demonstrated that NIC exacerbated OA‑mediated intracellular ROS production and cell injury through the transcriptional activation of p66shc. NIC also suppressed OA‑mediated induction of the antioxidant MnSOD promoter activity through p66shc‑dependent inactivation of FOXO activity. Overexpression of p66shc and knockdown of MnSOD had the same effect as treatment with NIC on OA‑mediated lipotoxicity. These data may be used to generate a therapeutic means to ameliorate renal lipotoxicity in obese smokers.

  1. Quantification of free-base and protonated nicotine in electronic cigarette liquids and aerosol emissions

    PubMed Central

    El-Hellani, Ahmad; El-Hage, Rachel; Baalbaki, Rima; Talih, Soha; Shihadeh, Alan; Saliba, Najat

    2016-01-01

    Introduction Reliable characterization of the nicotine content and emissions from electronic cigarettes (ECIGs) is crucial for product regulation. Understanding nicotine delivery, and therefore efficacy and abuse potential, from ECIG products requires quantifying the total nicotine contained or emitted, as well as the partitioning between its free-base and protonated forms. To date, studies reporting nicotine content and emissions of ECIGs have not addressed whether the reported values correspond to the total nicotine or only one of its forms, making the reported results difficult to compare across studies, or to correlate against blood exposure measurements. In this study we investigate whether nicotine in ECIGs is indeed present in more than one form, whether measurements are affected by sampling media, and report a validated method for determining total, free-base (Nic) and protonated nicotine (NicH+) in ECIG liquids and aerosol emissions. Methods We developed an analytical method based on liquid-liquid extraction coupled with GC analysis to assess the respective amounts of Nic and NicH+. The method was first verified on pH-controlled solutions (5 < pH < 10) and then was applied to several ECIG liquids and aerosols generated using a smoking machine. Results The method showed high repeatability and efficiency, and the results were in agreement with theoretical predictions based on measured pH of the standard nicotine solutions. ECIG liquids and aerosols contained both Nic and NicH+, and their relative proportions varied widely. Free-base nicotine was found to account for 18-95% of the total nicotine depending on the product in question. Conclusions The wide variation in nicotine partitioning across products suggests that studies of nicotine delivery from ECIGs should account for this factor. A convenient method for analyzing nicotine fractions in electronic cigarettes has been demonstrated. PMID:26158618

  2. Neutron imaging camera

    NASA Astrophysics Data System (ADS)

    Hunter, S. D.; de Nolfo, G. A.; Barbier, L. M.; Link, J. T.; Son, S.; Floyd, S. R.; Guardala, N.; Skopec, M.; Stark, B.

    2008-04-01

    The Neutron Imaging Camera (NIC) is based on the Three-dimensional Track Imager (3_DTI) technology developed at GSFC for gamma-ray astrophysics applications. The 3-DTI, a large volume time-projection chamber, provides accurate, ~0.4 mm resolution, 3-D tracking of charged particles. The incident direction of fast neutrons, En > 0.5 MeV, are reconstructed from the momenta and energies of the proton and triton fragments resulting from 3He(n,p)3H interactions in the 3-DTI volume. The performance of the NIC from laboratory is presented.

  3. Neutron Imaging Camera

    NASA Technical Reports Server (NTRS)

    Hunter, Stanley; deNolfo, G. A.; Barbier, L. M.; Link, J. T.; Son, S.; Floyd, S. R.; Guardala, N.; Skopec, M.; Stark, B.

    2008-01-01

    The Neutron Imaging Camera (NIC) is based on the Three-dimensional Track Imager (3DTI) technology developed at GSFC for gamma-ray astrophysics applications. The 3-DTI, a large volume time-projection chamber, provides accurate, approximately 0.4 mm resolution, 3-D tracking of charged particles. The incident direction of fast neutrons, En > 0.5 MeV, are reconstructed from the momenta and energies of the proton and triton fragments resulting from (sup 3)He(n,p) (sup 3)H interactions in the 3-DTI volume. The performance of the NIC from laboratory and accelerator tests is presented.

  4. Beach profile modification and sediment transport by ice: an overlooked process on Lake Michigan

    USGS Publications Warehouse

    Barnes, P.W.; Kempema, E.W.; Reimnitz, E.; McCormick, M.; Weber, W.S.; Hayden, E.C.

    1993-01-01

    Coastal lake ice includes a belt of mobile crash and slush ice and a stable nearshore-ice complex (NIC). Sediment concentrations indicate that the NIC and the belt of brash and slush contains 180 to 280 t (113 to 175m3) of sand per kilometer of coast. This static sediment load is roughly equivalent to the average amount of sand eroded from the bluffs and to the amount accumulating in the deep lake basin each year. Sediment is being rafted alongshore in the mobile brash and slush at rates of 10 to 30 cm/sec. -from Authors

  5. Magnetic criteria of aromaticity.

    PubMed

    Gershoni-Poranne, Renana; Stanger, Amnon

    2015-09-21

    This review describes the current state of magnetic criteria of aromaticity. The introduction contains the fundamentals of ring currents in aromatic and antiaromatic systems, followed by a brief description of experimental and computational tools: NMR, diamagnetic susceptibility exaltation, current density analyses (CDA) and nucleus independent chemical shifts (NICS). This is followed by more comprehensive chapters: NMR - focusing on the work of R. Mitchell - NICS and CDA - describing the progress and development of the methods to their current state and presenting some examples of representative work. PMID:26035305

  6. A theory of heating of quiet solar corona

    SciTech Connect

    Wu, C. S.; Yoon, P. H.; Wang, C. B.

    2015-03-15

    A theory is proposed to discuss the creation of hot solar corona. We pay special attention to the transition region and the low corona, and consider that the sun is quiet. The proposed scenario suggests that the protons are heated by intrinsic Alfvénic turbulence, while the ambient electrons are heated by the hot protons via collisions. The theory contains two prime components: the generation of the Alfvénic fluctuations by the heavy minor ions in the transition region and second, the explanation of the temperature profile in the low solar atmosphere. The proposed heating process operates continuously in time and globally in space.

  7. Lessons from Two Years of Building Fusion Ignition Targets with the Precision Robotic Assembly Machine

    SciTech Connect

    Montesanti, R C; Alger, E T; Atherton, L J; Bhandarkar, S D; Castro, C; Dzenitis, E G; Hamza, A V; Klingmann, J L; Nikroo, A; Parham, T G; Reynolds, J L; Seugling, R M; Swisher, M F; Taylor, J S; Witte, M C

    2010-02-19

    The Precision Robotic Assembly Machine was developed to manufacture the small and intricate laser-driven fusion ignition targets that are being used in the world's largest and most energetic laser, the National Ignition Facility (NIF). The National Ignition Campaign (NIC) goal of using the NIF to produce a self-sustaining nuclear fusion burn with energy gain - for the first time ever in a laboratory setting - requires targets that are demanding in materials fabrication, machining, and assembly. We provide an overview of the design and function of the machine, with emphasis on the aspects that revolutionized how NIC targets are manufactured.

  8. The application of low-bit-rate encoding techniques to digital satellite systems

    NASA Astrophysics Data System (ADS)

    Rowbotham, T. R.; Niwa, K.

    This paper describes the INTELSAT-funded development on low-bit-rate voice encoding techniques. Adaptive Differential Pulse Code Modulation (ADPCM), Nearly Instantaneous Companding (NIC) and Continuously Variable Slope Delta Modulation (CVSD). Subjective and objective evaluation results, with and without transmission errors are presented, primarily for 32 kbit/s per voice channel. A part of the paper is devoted to the interfacing of ADPCM, NIC and CVSD with terrestrial ISDM and satellite networks, the frame structure and how signalling can be accommodated, and the compatibility with other voice-associated digital processors such as DSI and Echo Cancellers.

  9. Central role of fibroblast alpha3 nicotinic acetylcholine receptor in mediating cutaneous effects of nicotine.

    PubMed

    Arredondo, Juan; Hall, Leon L; Ndoye, Assane; Nguyen, Vu Thuong; Chernyavsky, Alexander I; Bercovich, Dani; Orr-Urtreger, Avi; Beaudet, Arthur L; Grando, Sergei A

    2003-02-01

    Smoking is associated with aberrant cutaneous tissue remodeling, such as precocious skin aging and impaired wound healing. The mechanism is not fully understood. Dermal fibroblasts (DF) are the primary cellular component of the dermis and may provide a target for pathobiologic effects of tobacco products. The purpose of this study was to characterize a mechanism of nicotine (Nic) effects on the growth and tissue remodeling function of DF. We hypothesized that the effects of Nic on DF result from its binding to specific nicotinic acetylcholine receptors (nAChRs) expressed by these cells and that downstream signaling from the receptors alters normal cell functioning, leading to changes in skin homeostasis. Using RT-PCR and Western blotting, we found that a 24-hour exposure of human DF to 10 micro M Nic causes a 1.9- to 28-fold increase of the mRNA and protein levels of the cell cycle regulators p21, cyclin D1, Ki-67, and PCNA and a 1.7- to 2-fold increase of the apoptosis regulators Bcl-2 and caspase 3. Nic exposure also up-regulated expression of the dermal matrix proteins collagen type Ialpha1 and elastin as well as matrix metalloproteinase-1. Mecamylamine (Mec), the specific antagonist of nAChRs, abolished Nic-induced alterations, indicating that they resulted from a pharmacologic stimulation of nAChRs expressed by DF. To establish the relevance of these findings to a specific nicotinergic pathway, we studied human DF transfected with anti-alpha3 antisense oligonucleotides and murine DF from alpha3 nAChR knockout mice. In both cases, lack of alpha3 was associated with alterations in fibroblast growth and function that were opposite to those observed in DF treated with Nic, suggesting that the nicotinic effects on DF were mostly mediated by alpha3 nAChR. In addition to alpha3, the nAChR subunits detected in human DF were alpha5, alpha7, beta2, and beta4. The exposure of DF to Nic altered the relative amounts of each of these subunits, leading to reciprocal changes

  10. Magnetic criteria of aromaticity.

    PubMed

    Gershoni-Poranne, Renana; Stanger, Amnon

    2015-09-21

    This review describes the current state of magnetic criteria of aromaticity. The introduction contains the fundamentals of ring currents in aromatic and antiaromatic systems, followed by a brief description of experimental and computational tools: NMR, diamagnetic susceptibility exaltation, current density analyses (CDA) and nucleus independent chemical shifts (NICS). This is followed by more comprehensive chapters: NMR - focusing on the work of R. Mitchell - NICS and CDA - describing the progress and development of the methods to their current state and presenting some examples of representative work.

  11. The Linear Instability of Astrophysical Flames in Magnetic Fields

    NASA Astrophysics Data System (ADS)

    Dursi, L. J.

    2004-05-01

    Supernovae of Type Ia are used as standard candles for cosmological observations despite the as yet incomplete understanding of their explosion mechanism. In one model, these events are thought to result from subsonic burning in the core of an accreting carbon/oxygen white dwarf that is accelerated through flame wrinkling and flame instabilities. Many such white dwarfs have significant magnetic fields. Here we derive the linear effects of such magnetic fields on one flame instability, the well-known Landau-Darrieus instability. When the magnetic field is strong enough that the flame is everywhere sub-Alfvénic, the instability can be greatly suppressed. Super-Alfvénic flames are much less affected by the field, with flames propagating parallel to the field somewhat destabilized and flames propagating perpendicular to the field somewhat stabilized. Trans-Alfvénic parallel flames, however, like trans-Alfvénic parallel shocks, are seen to be nonevolutionary; understanding the behavior of these flames will require careful numerical simulation.

  12. 28 CFR 25.4 - Record source categories.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....4 Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.4 Record source categories. It is anticipated that... to the NICS Index. Information in the NCIC and III systems that will be searched during a...

  13. 28 CFR 25.1 - Purpose and authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE DEPARTMENT OF JUSTICE INFORMATION SYSTEMS The National Instant Criminal Background Check System § 25.1 Purpose and authority. The purpose of this subpart is to... Instant Criminal Background Check System (NICS) to be contacted by any licensed importer,...

  14. Three-dimensional nonlinear ideal MHD equilibria with field-aligned incompressible and compressible flows

    NASA Astrophysics Data System (ADS)

    Moawad, S. M.; Ibrahim, D. A.

    2016-08-01

    The equilibrium properties of three-dimensional ideal magnetohydrodynamics (MHD) are investigated. Incompressible and compressible flows are considered. The governing equations are taken in a steady state such that the magnetic field is parallel to the plasma flow. Equations of stationary equilibrium for both of incompressible and compressible MHD flows are derived and described in a mathematical mode. For incompressible MHD flows, Alfvénic and non-Alfvénic flows with constant and variable magnetofluid density are investigated. For Alfvénic incompressible flows, the general three-dimensional solutions are determined with the aid of two potential functions of the velocity field. For non-Alfvénic incompressible flows, the stationary equilibrium equations are reduced to two differential constraints on the potential functions, flow velocity, magnetofluid density, and the static pressure. Some examples which may be of some relevance to axisymmetric confinement systems are presented. For compressible MHD flows, equations of the stationary equilibrium are derived with the aid of a single potential function of the velocity field. The existence of three-dimensional solutions for these MHD flows is investigated. Several classes of three-dimensional exact solutions for several cases of nonlinear equilibrium equations are presented.

  15. 28 CFR 25.5 - Validation and data integrity of records in the system.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of records in the system. (a) The FBI will be responsible for maintaining data integrity during all NICS operations that are managed and carried out by the FBI. This responsibility includes: (1) Ensuring... of time; and (4) Quality control checks in the form of periodic internal audits by FBI personnel...

  16. 28 CFR 25.5 - Validation and data integrity of records in the system.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of records in the system. (a) The FBI will be responsible for maintaining data integrity during all NICS operations that are managed and carried out by the FBI. This responsibility includes: (1) Ensuring... of time; and (4) Quality control checks in the form of periodic internal audits by FBI personnel...

  17. 28 CFR 25.5 - Validation and data integrity of records in the system.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of records in the system. (a) The FBI will be responsible for maintaining data integrity during all NICS operations that are managed and carried out by the FBI. This responsibility includes: (1) Ensuring... of time; and (4) Quality control checks in the form of periodic internal audits by FBI personnel...

  18. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may...

  19. 28 CFR 25.5 - Validation and data integrity of records in the system.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of records in the system. (a) The FBI will be responsible for maintaining data integrity during all NICS operations that are managed and carried out by the FBI. This responsibility includes: (1) Ensuring... of time; and (4) Quality control checks in the form of periodic internal audits by FBI personnel...

  20. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may...

  1. 28 CFR 25.9 - Retention and destruction of records in the system.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... in accordance with established policy. (b) The FBI will maintain an automated NICS Audit Log of all... may be accessed directly only by the FBI and only for the purpose of conducting audits of the use and... license number of the FFL and the proposed date of inspection of the named FFL by ATF, the FBI may...

  2. 28 CFR 25.5 - Validation and data integrity of records in the system.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of records in the system. (a) The FBI will be responsible for maintaining data integrity during all NICS operations that are managed and carried out by the FBI. This responsibility includes: (1) Ensuring... of time; and (4) Quality control checks in the form of periodic internal audits by FBI personnel...

  3. The National In-Service Courses for Science Teachers and Their Effect on Educational Reform in Mexico

    ERIC Educational Resources Information Center

    Garcia, Alejandra; Flores, Fernando; Gallegos, Leticia

    2005-01-01

    The educational system in Mexico has undergone important changes in recent decades. One of the most important took place in 1993, when the compulsory character of secondary school (ages 12-15) was established. National In-service Courses (NICs) were established as a way to bring curricular changes proposed in the reform near to the teachers. The…

  4. The Amazing Internet Challenge: How Leading Projects Use Library Skills To Organize the Web.

    ERIC Educational Resources Information Center

    Wells, Amy Tracy; Calcari, Susan; Koplow, Travis

    This book describes how the following 12 virtual libraries use library skills to organize Internet resources: Agriculture Network Information Center (AgNIC); Argus Clearinghouse; Blue Web'n; BUBL Information Service; Edinburgh Engineering Virtual Library (EEVL); INFOMINE; Internet Public Library (IPL); Librarians' Index to the Internet (LII);…

  5. Evaluation of Education of Inner City Handicapped Children, Case Studies in Five Cities. Volume I, Final Report.

    ERIC Educational Resources Information Center

    Abram, Robert E.; And Others

    Reported was an evaluation of the education of inner city (IC) handicapped children in five cities. Focused on were an assessment of present education programs, a comparison of services provided IC children with services provided non-inner city (NIC) children, a determination of needs unique to handicapped children in inner city areas, formulation…

  6. Student Completion Rates during Three Different Pacing Conditions. REDEAL Research Report #12. Project REDEAL. Research and Evaluation of Distance Education for the Adult Learner.

    ERIC Educational Resources Information Center

    Crawford, Gail

    Three institutions effected agreements enabling students in all of the institutions to enroll in the same course, a six-credit introductory psychology course. The three institutions--Athabasca University (AU), The Open Learning Institute (OLI), and North Island College (NIC)--were distance education institutions with open admissions policies which…

  7. User Procedures Standardization for Network Access. NBS Technical Note 799.

    ERIC Educational Resources Information Center

    Neumann, A. J.

    User access procedures to information systems have become of crucial importance with the advent of computer networks, which have opened new types of resources to a broad spectrum of users. This report surveys user access protocols of six representative systems: BASIC, GE MK II, INFONET, MEDLINE, NIC/ARPANET and SPIRES. Functional access…

  8. The Story behind "Quest for the Tree Kangaroo"

    ERIC Educational Resources Information Center

    Young, Terrell A.; Ward, Barbara A.

    2007-01-01

    The National Council of Teachers of English awarded the coveted nonfiction prize to "Quest for the Tree Kangaroo: An Expedition to the Cloud Forest of New Guinea." Written by Sy Montgomery, with photographs by Nic Bishop, the book was further honored as a Robert F. Sibert Informational Book Medal Honor recipient by the Association for Library…

  9. Teaching with the Newspaper

    ERIC Educational Resources Information Center

    Street, Chris

    2002-01-01

    The newspaper is a source of up-to-date and compelling information that teachers can use to teach current events. In this article, the author discusses why it makes sense for social studies educators to use newspapers in their classrooms. He also presents information about the Newspaper in Education (NIC) program and explains how interested…

  10. Keeping an Uphill Edge: Managing Cleaning Behaviors at a Ski Shop

    ERIC Educational Resources Information Center

    Doll, Jessica; Livesey, Josh; McHaffie, Elizabeth; Ludwig, Timothy D.

    2007-01-01

    Several behaviors in a ski shop were identified as being deficient using Austin's Performance Diagnostic Checklist (2000) and Daniels and Daniels' PIC/NIC Analysis (2004). During a 4-week baseline, 7 cleaning behaviors were monitored and 5 were subsequently targeted in an intervention package using an ABC design. The intervention included: a task…

  11. Third Year Continuation of a Research and Design Criteria for the Implementation and Establishment of a Neighborhood Information Center in Five Public Libraries: Atlanta, Cleveland, Detroit, Houston, and Queens Borough. Final Summary Report.

    ERIC Educational Resources Information Center

    Childers, Thomas

    The 1972-1975 Neighborhood Information Center (NIC) Project was undertaken in Atlanta, Cleveland, Detroit, Houston, and Queens Borough to demonstrate the feasibility of using existing library branches as neighborhood information centers. This summary evaluation utilized data from site visits, interviews with staff and clients, a questionnaire…

  12. Evaluative Study of the Neighborhood Information Center Project.

    ERIC Educational Resources Information Center

    Franklin, Hardy R.; Summers, F. William

    The 1972-1974 Neighborhood Information Center (NIC) Project was undertaken in Atlanta, Cleveland, Detroit, Houston, and Queens Borough to demonstrate that urban public libraries could be a vital force in daily living by providing free information and referrals to low income communities, and by adapting in non-traditional ways to meet neighborhood…

  13. Annotated Bibliography on Offender Job Training and Placement. Second Edition.

    ERIC Educational Resources Information Center

    Clem, Constance, Ed.

    This second edition of an annotated bibliography on offender job training and placement lists nearly 400 items from the collection of the National Institute of Corrections (NIC) Information Center in Longmont, Colorado, including 85 items added since the first edition in 1997. Items new to this edition are marked with an asterisk. Citations have…

  14. The Efficacy of Learning Communities at Two Community Colleges.

    ERIC Educational Resources Information Center

    Minkler, James E.

    This study examined learning communities at two community colleges, North Idaho College (NIC) and Spokane Falls Community College (SFCC) (Washington). Recent emphasis on learning outcomes and transforming the curriculum to be more learning centered has often come into direct conflict with operating under tight budget constraints. Learning…

  15. A Needs Assessment of Aquaculture Extension Agents, Specialists, and Program Administrators in Extension Programming

    ERIC Educational Resources Information Center

    Schwarz, Michael H.; Gibson, Jerry

    2010-01-01

    The study reported here identified continuing education and training needs of aquaculture Extension agents, specialists, and program administrators in 10 competency areas relating to the need for continuing education or training. Fourteen resources on the AquaNIC Web site were also evaluated, as was the efficacy of the AQUA-EXT listserv. Data were…

  16. Higher Education and Development: The Experience of Four Newly Industrializing Countries in Asia.

    ERIC Educational Resources Information Center

    Singh, Jasbir Sarjit

    1991-01-01

    Reviews developments in higher education in four Newly Industrialized Countries (NICs) in east Asia. Contends that improvements have resulted from policies that strengthen and develop scientific and technological capacity. Stresses the link between effective higher education and economic well-being. (CFR)

  17. Theoretical characterisation of irreversible and reversible hydrogen storage reactions on Ni-doped C60 fullerene

    NASA Astrophysics Data System (ADS)

    Shalabi, A. S.; El Mahdy, A. M.; Soliman, K. A.; Taha, H. O.

    2014-12-01

    An attempt has been made to characterise the irreversible and reversible hydrogen storage reactions on Ni-doped C60 fullerene by using the state of the art density functional theory calculations. The single Ni atom prefers to bind at the bridge site between two hexagonal rings of C60 fullerene, and can bind up to four hydrogen molecules with average adsorption energies of -0.85, -0.83, -0.58, and -0.31 eV per hydrogen molecule. No evidence for metal clustering in the ideal circumstances and the hydrogen storage capacity is expected to be as large as 8.9 wt%. While the desorption activation barriers of the complexes nH2NiC60 (n = 1, 2) are outside the desirable energy window recommended by the department of energy for practical applications (-0.2 to -0.6 eV), the desorption activation barriers of the complexes nH2NiC60 (n = 3, 4) are inside this window. The irreversible 2H2 + NiC60 and reversible 3H2 + NiC60 interactions are characterised in terms of several theoretical parameters such as: (1) densities of states and projected densities of states, (2) pairwise and non-pairwise additivity, (3) infrared, Raman, and proton magnetic resonance spectra, (4) electrophilicity, and (5) statistical thermodynamic stability.

  18. An Experiment in Library Communications.

    ERIC Educational Resources Information Center

    Shirk, John C.

    The Carnegie Branch of the Houston Public Library (HPL) has attempted to establish credibility in a low income, Spanish speaking neighborhood by making the library visible to individuals on the street, contacting community leaders, and working with dropouts. The Branch, selected to implement a Neighborhood Information Center (NIC), established a…

  19. Magnetic fabrics and petrology of the Newry Igneous Complex, Northern Ireland reveals a new emplacement model

    NASA Astrophysics Data System (ADS)

    Anderson, Paul; Stevenson, Carl; Cooper, Mark; Ellam, Rob; Meighan, Ian; Hurley, Colm; Reavy, John; Inman, James; Condon, Dan; Crowley, Quentin

    2013-04-01

    The Newry Igneous Complex (NIC) is a largely granodioritic intrusion, comprising three plutons together with an intermediate-ultramafic body at its NE end. The recent Tellus survey of Northern Ireland has highlighted several geophysical anomalies within this area, including two previously unrecognised concentric aeromagnetic structures. U-Pb zircon ages and a geochemical study suggest that these features represent magmas intruded at different times, and that each pluton was emplaced through a series of inward-younging, concentric pulses. A combination of anisotropy of magnetic susceptibility (AMS) and field relations were used to investigate the emplacement of these pulses. AMS reveals strong, dominantly oblate, concentric fabrics. These suggest forceful emplacement. Field relationships indicate that the complex was intruded as steep, sheet-like pulses. Host rocks show deflection of fabrics around the NIC supporting the forceful emplacemnt model. However the amount of strain recorded in the host rocks does not fully explain the space required for intrusion. The presence of a deeply penetrating tectontic structure offers a way to transport magma and create space through a releasing bend. The releasing bend would have created some of the space for intrusion to take place initially and likely guided the ascent of magma. However, the strong fabrics present within the NIC suggest that most of the space for the intrusion was created in a forceful way. Therefore, the NIC was emplaced as a ballooning type pluton after ascent through a tectonically created conduit along a deeply penetrating fault.

  20. Automation and Networking of Public Libraries in India Using the E-Granthalaya Software from the National Informatics Centre

    ERIC Educational Resources Information Center

    Matoria, Ram Kumar; Upadhyay, P. K.; Moni, Madaswamy

    2007-01-01

    Purpose: To describe the development of the library management system, e-Granthalaya, for public libraries in India. This is an initiative of the Indian government's National Informatics Centre (NIC). The paper outlines the challenges and the potential of a full-scale deployment of this software at a national level. Design/methodology/approach:…