Analytical gradients for tensor hyper-contracted MP2 and SOS-MP2 on graphical processing units

DOE PAGES

Song, Chenchen; Martinez, Todd J.

2017-08-29

Analytic energy gradients for tensor hyper-contraction (THC) are derived and implemented for second-order Møller-Plesset perturbation theory (MP2), with and without the scaled-opposite-spin (SOS)-MP2 approximation. By exploiting the THC factorization, the formal scaling of MP2 and SOS-MP2 gradient calculations with respect to system size is reduced to quartic and cubic, respectively. An efficient implementation has been developed that utilizes both graphics processing units and sparse tensor techniques exploiting spatial sparsity of the atomic orbitals. THC-MP2 has been applied to both geometry optimization and ab initio molecular dynamics (AIMD) simulations. Furthermore, the resulting energy conservation in micro-canonical AIMD demonstrates that the implementationmore » provides accurate nuclear gradients with respect to the THC-MP2 potential energy surfaces.« less

Analytical gradients for tensor hyper-contracted MP2 and SOS-MP2 on graphical processing units

NASA Astrophysics Data System (ADS)

Song, Chenchen; Martínez, Todd J.

2017-10-01

Analytic energy gradients for tensor hyper-contraction (THC) are derived and implemented for second-order Møller-Plesset perturbation theory (MP2), with and without the scaled-opposite-spin (SOS)-MP2 approximation. By exploiting the THC factorization, the formal scaling of MP2 and SOS-MP2 gradient calculations with respect to system size is reduced to quartic and cubic, respectively. An efficient implementation has been developed that utilizes both graphics processing units and sparse tensor techniques exploiting spatial sparsity of the atomic orbitals. THC-MP2 has been applied to both geometry optimization and ab initio molecular dynamics (AIMD) simulations. The resulting energy conservation in micro-canonical AIMD demonstrates that the implementation provides accurate nuclear gradients with respect to the THC-MP2 potential energy surfaces.

Analytical gradients for tensor hyper-contracted MP2 and SOS-MP2 on graphical processing units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Song, Chenchen; Martinez, Todd J.

Analytic energy gradients for tensor hyper-contraction (THC) are derived and implemented for second-order Møller-Plesset perturbation theory (MP2), with and without the scaled-opposite-spin (SOS)-MP2 approximation. By exploiting the THC factorization, the formal scaling of MP2 and SOS-MP2 gradient calculations with respect to system size is reduced to quartic and cubic, respectively. An efficient implementation has been developed that utilizes both graphics processing units and sparse tensor techniques exploiting spatial sparsity of the atomic orbitals. THC-MP2 has been applied to both geometry optimization and ab initio molecular dynamics (AIMD) simulations. Furthermore, the resulting energy conservation in micro-canonical AIMD demonstrates that the implementationmore » provides accurate nuclear gradients with respect to the THC-MP2 potential energy surfaces.« less

Software to model AXAF image quality

NASA Technical Reports Server (NTRS)

Ahmad, Anees

1993-01-01

This draft final report describes the work performed under this delivery order from May 1992 through June 1993. The purpose of this contract was to enhance and develop an integrated optical performance modeling software for complex x-ray optical systems such as AXAF. The GRAZTRACE program developed by the MSFC Optical Systems Branch for modeling VETA-I was used as the starting baseline program. The original program was a large single file program and, therefore, could not be modified very efficiently. The original source code has been reorganized, and a 'Make Utility' has been written to update the original program. The new version of the source code consists of 36 small source files to make it easier for the code developer to manage and modify the program. A user library has also been built and a 'Makelib' utility has been furnished to update the library. With the user library, the users can easily access the GRAZTRACE source files and build a custom library. A user manual for the new version of GRAZTRACE has been compiled. The plotting capability for the 3-D point spread functions and contour plots has been provided in the GRAZTRACE using the graphics package DISPLAY. The Graphics emulator over the network has been set up for programming the graphics routine. The point spread function and the contour plot routines have also been modified to display the plot centroid, and to allow the user to specify the plot range, and the viewing angle options. A Command Mode version of GRAZTRACE has also been developed. More than 60 commands have been implemented in a Code-V like format. The functions covered in this version include data manipulation, performance evaluation, and inquiry and setting of internal parameters. The user manual for these commands has been formatted as in Code-V, showing the command syntax, synopsis, and options. An interactive on-line help system for the command mode has also been accomplished to allow the user to find valid commands, command syntax, and command function. A translation program has been written to convert FEA output from structural analysis to GRAZTRACE surface deformation file (.dfm file). The program can accept standard output files and list files from COSMOS/M and NASTRAN finite analysis programs. Some interactive options are also provided, such as Cartesian or cylindrical coordinate transformation, coordinate shift and scale, and axial length change. A computerized database for technical documents relating to the AXAF project has been established. Over 5000 technical documents have been entered into the master database. A user can now rapidly retrieve the desired documents relating to the AXAF project. The summary of the work performed under this contract is shown.

48 CFR 22.1003-5 - Some examples of contracts covered.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CFR 4.130 for additional examples): (a) Motor pool operation, parking, taxicab, and ambulance services...) Certain specialized services requiring specific skills, such as drafting, illustrating, graphic arts..., engines, electrical motors, vehicles, and electronic, office and related business and construction...

Graphical function mapping as a new way to explore cause-and-effect chains

USGS Publications Warehouse

Evans, Mary Anne

2016-01-01

Graphical function mapping provides a simple method for improving communication within interdisciplinary research teams and between scientists and nonscientists. This article introduces graphical function mapping using two examples and discusses its usefulness. Function mapping projects the outcome of one function into another to show the combined effect. Using this mathematical property in a simpler, even cartoon-like, graphical way allows the rapid combination of multiple information sources (models, empirical data, expert judgment, and guesses) in an intuitive visual to promote further discussion, scenario development, and clear communication.

New algorithm for tensor contractions on multi-core CPUs, GPUs, and accelerators enables CCSD and EOM-CCSD calculations with over 1000 basis functions on a single compute node.

PubMed

Kaliman, Ilya A; Krylov, Anna I

2017-04-30

A new hardware-agnostic contraction algorithm for tensors of arbitrary symmetry and sparsity is presented. The algorithm is implemented as a stand-alone open-source code libxm. This code is also integrated with general tensor library libtensor and with the Q-Chem quantum-chemistry package. An overview of the algorithm, its implementation, and benchmarks are presented. Similarly to other tensor software, the algorithm exploits efficient matrix multiplication libraries and assumes that tensors are stored in a block-tensor form. The distinguishing features of the algorithm are: (i) efficient repackaging of the individual blocks into large matrices and back, which affords efficient graphics processing unit (GPU)-enabled calculations without modifications of higher-level codes; (ii) fully asynchronous data transfer between disk storage and fast memory. The algorithm enables canonical all-electron coupled-cluster and equation-of-motion coupled-cluster calculations with single and double substitutions (CCSD and EOM-CCSD) with over 1000 basis functions on a single quad-GPU machine. We show that the algorithm exhibits predicted theoretical scaling for canonical CCSD calculations, O(N 6 ), irrespective of the data size on disk. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Big system: Interactive graphics for the engineer

NASA Technical Reports Server (NTRS)

Quenneville, C. E.

1975-01-01

The BCS Interactive Graphics System (BIG System) approach to graphics was presented, along with several significant engineering applications. The BIG System precompiler, the graphics support library, and the function requirements of graphics applications are discussed. It was concluded that graphics standardization and a device independent code can be developed to assure maximum graphic terminal transferability.

Political Corruption and the Media: The Tangentopoli Affair.

ERIC Educational Resources Information Center

Giglioli, Pier Paolo

1996-01-01

Examines the role of the media in the social construction of the Tangentopoli affair. Originally perceived as a minor scandal involving kickbacks on a cleaning contract, Tangentopoli became a rallying cry for reform, and seriously affected the 1994 Italian elections. Includes graphical analysis of media coverage. (MJP)

Dynamic Graphics in Excel for Teaching Statistics: Understanding the Probability Density Function

ERIC Educational Resources Information Center

Coll-Serrano, Vicente; Blasco-Blasco, Olga; Alvarez-Jareno, Jose A.

2011-01-01

In this article, we show a dynamic graphic in Excel that is used to introduce an important concept in our subject, Statistics I: the probability density function. This interactive graphic seeks to facilitate conceptual understanding of the main aspects analysed by the learners.

Tensor Algebra Library for NVidia Graphics Processing Units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liakh, Dmitry

This is a general purpose math library implementing basic tensor algebra operations on NVidia GPU accelerators. This software is a tensor algebra library that can perform basic tensor algebra operations, including tensor contractions, tensor products, tensor additions, etc., on NVidia GPU accelerators, asynchronously with respect to the CPU host. It supports a simultaneous use of multiple NVidia GPUs. Each asynchronous API function returns a handle which can later be used for querying the completion of the corresponding tensor algebra operation on a specific GPU. The tensors participating in a particular tensor operation are assumed to be stored in local RAMmore » of a node or GPU RAM. The main research area where this library can be utilized is the quantum many-body theory (e.g., in electronic structure theory).« less

Mass data graphics requirements for symbol generators: example 2D airport navagation and 3D terrain function

NASA Astrophysics Data System (ADS)

Schiefele, Jens; Bader, Joachim; Kastner, S.; Wiesemann, Thorsten; von Viebahn, Harro

2002-07-01

Next generation of cockpit display systems will display mass data. Mass data includes terrain, obstacle, and airport databases. Display formats will be two and eventually 3D. A prerequisite for the introduction of these new functions is the availability of certified graphics hardware. The paper describes functionality and required features of an aviation certified 2D/3D graphics board. This graphics board should be based on low-level and hi-level API calls. These graphic calls should be very similar to OpenGL. All software and the API must be aviation certified. As an example application, a 2D airport navigation function and a 3D terrain visualization is presented. The airport navigation format is based on highly precise airport database following EUROCAE ED-99/RTCA DO-272 specifications. Terrain resolution is based on EUROCAE ED-98/RTCA DO-276 requirements.

Graphic design of pinhole cameras

NASA Technical Reports Server (NTRS)

Edwards, H. B.; Chu, W. P.

1979-01-01

The paper describes a graphic technique for the analysis and optimization of pinhole size and focal length. The technique is based on the use of the transfer function of optical elements described by Scott (1959) to construct the transfer function of a circular pinhole camera. This transfer function is the response of a component or system to a pattern of lines having a sinusoidally varying radiance at varying spatial frequencies. Some specific examples of graphic design are presented.

Bibliography of In-House and Contract Reports. Supplement 9.

DTIC Science & Technology

1981-02-01

11;il CasCil roads andl ril roads would significantlN rcduLcc tlic ~anIual labor IMnOls d III V, i 1111111 d il.1 . graphic data bascs. ile effort...GUIDE FOR CLIMA TE (Rpt. No. 5 in the ETL Series on Guides for Army Terrain Analysts) September 1980 Keywords: Climatic Analysis, Factor Mapping

EMGD-FE: an open source graphical user interface for estimating isometric muscle forces in the lower limb using an EMG-driven model

PubMed Central

2014-01-01

Background This paper describes the “EMG Driven Force Estimator (EMGD-FE)”, a Matlab® graphical user interface (GUI) application that estimates skeletal muscle forces from electromyography (EMG) signals. Muscle forces are obtained by numerically integrating a system of ordinary differential equations (ODEs) that simulates Hill-type muscle dynamics and that utilises EMG signals as input. In the current version, the GUI can estimate the forces of lower limb muscles executing isometric contractions. Muscles from other parts of the body can be tested as well, although no default values for model parameters are provided. To achieve accurate evaluations, EMG collection is performed simultaneously with torque measurement from a dynamometer. The computer application guides the user, step-by-step, to pre-process the raw EMG signals, create inputs for the muscle model, numerically integrate the ODEs and analyse the results. Results An example of the application’s functions is presented using the quadriceps femoris muscle. Individual muscle force estimations for the four components as well the knee isometric torque are shown. Conclusions The proposed GUI can estimate individual muscle forces from EMG signals of skeletal muscles. The estimation accuracy depends on several factors, including signal collection and modelling hypothesis issues. PMID:24708668

EMGD-FE: an open source graphical user interface for estimating isometric muscle forces in the lower limb using an EMG-driven model.

PubMed

Menegaldo, Luciano Luporini; de Oliveira, Liliam Fernandes; Minato, Kin K

2014-04-04

This paper describes the "EMG Driven Force Estimator (EMGD-FE)", a Matlab® graphical user interface (GUI) application that estimates skeletal muscle forces from electromyography (EMG) signals. Muscle forces are obtained by numerically integrating a system of ordinary differential equations (ODEs) that simulates Hill-type muscle dynamics and that utilises EMG signals as input. In the current version, the GUI can estimate the forces of lower limb muscles executing isometric contractions. Muscles from other parts of the body can be tested as well, although no default values for model parameters are provided. To achieve accurate evaluations, EMG collection is performed simultaneously with torque measurement from a dynamometer. The computer application guides the user, step-by-step, to pre-process the raw EMG signals, create inputs for the muscle model, numerically integrate the ODEs and analyse the results. An example of the application's functions is presented using the quadriceps femoris muscle. Individual muscle force estimations for the four components as well the knee isometric torque are shown. The proposed GUI can estimate individual muscle forces from EMG signals of skeletal muscles. The estimation accuracy depends on several factors, including signal collection and modelling hypothesis issues.

fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages

PubMed Central

Hoffmann, Thomas J.; Laird, Nan M.

2009-01-01

The fgui R package is designed for developers of R packages, to help rapidly, and sometimes fully automatically, create a graphical user interface for a command line R package. The interface is built upon the Tcl/Tk graphical interface included in R. The package further facilitates the developer by loading in the help files from the command line functions to provide context sensitive help to the user with no additional effort from the developer. Passing a function as the argument to the routines in the fgui package creates a graphical interface for the function, and further options are available to tweak this interface for those who want more flexibility. PMID:21625291

Optimizing Tensor Contraction Expressions for Hybrid CPU-GPU Execution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Wenjing; Krishnamoorthy, Sriram; Villa, Oreste

2013-03-01

Tensor contractions are generalized multidimensional matrix multiplication operations that widely occur in quantum chemistry. Efficient execution of tensor contractions on Graphics Processing Units (GPUs) requires several challenges to be addressed, including index permutation and small dimension-sizes reducing thread block utilization. Moreover, to apply the same optimizations to various expressions, we need a code generation tool. In this paper, we present our approach to automatically generate CUDA code to execute tensor contractions on GPUs, including management of data movement between CPU and GPU. To evaluate our tool, GPU-enabled code is generated for the most expensive contractions in CCSD(T), a key coupledmore » cluster method, and incorporated into NWChem, a popular computational chemistry suite. For this method, we demonstrate speedup over a factor of 8.4 using one GPU (instead of one core per node) and over 2.6 when utilizing the entire system using hybrid CPU+GPU solution with 2 GPUs and 5 cores (instead of 7 cores per node). Finally, we analyze the implementation behavior on future GPU systems.« less

CHARGE Image Generator: Theory of Operation and Author Language Support. Technical Report 75-3.

ERIC Educational Resources Information Center

Gunwaldsen, Roger L.

The image generator function and author language software support for the CHARGE (Color Halftone Area Graphics Environment) Interactive Graphics System are described. Designed initially for use in computer-assisted instruction (CAI) systems, the CHARGE Interactive Graphics System can provide graphic displays for various applications including…

Calcium Channels, Rho-Kinase, Protein Kinase-C, and Phospholipase-C Pathways Mediate Mercury Chloride-Induced Myometrial Contractions in Rats.

PubMed

Koli, Swati; Prakash, Atul; Choudhury, Soumen; Mandil, Rajesh; Garg, Satish K

2018-05-21

Adverse effects of mercury on female reproduction are reported; however, its effect on myogenic activity of uterus and mechanism thereof is obscure. Present study was undertaken to unravel the mechanistic pathways of mercuric chloride (HgCl 2 )-induced myometrial contraction in rats. Isometric tension in myometrial strips of rats following in vitro exposure to HgCl 2 was recorded using data acquisition system-based physiograph. HgCl 2 produced concentration-dependent (10 nM-100 μM) uterotonic effect which was significantly (p < 0.05) reduced in Ca 2+ -free solution and inhibited in the presence of nifedipine (1 μM), a L-type Ca 2+ channel blocker, thus suggesting the importance of extracellular Ca 2+ and its entry through L-type calcium channels in HgCl 2 -induced myometrial contractions in rats. Cumulative concentration-response curve of HgCl 2 was significantly (p < 0.05) shifted towards right in the presence of Y-27632 (10 μM), a Rho-kinase inhibitor, suggesting the involvement of Ca 2+ -sensitization pathway in mediating HgCl 2 -induced myometrial contraction. HgCl 2 -induced myometrial contraction was also significantly (p < 0.05) inhibited in the presence of methoctramine or para-fluoro-hexahydro-siladifenidol, a selective M 2 and M 3 receptor antagonists, respectively, which evidently suggest that mercury also interacts with M 2 and M 3 muscarinic receptors to produce myometrial contractions. U-73122 and GF-109203X, the respective inhibitors of PLC and PKC-dependent pathways, downstream to the receptor activation, also significantly (p < 0.05) attenuated the uterotonic effect of HgCl 2 on rat uterus. Taken together, present study evidently reveals that HgCl 2 interacts with muscarinic receptors and activates calcium signaling cascades involving calcium channels, Rho-kinase, protein kinase-C, and phospholipase-C pathways to exert uterotonic effect in rats. Graphical Abstract Graphical abstract depicting the mechanism of mercury-induced myometrial contraction in rats. M receptor: Muscarinic receptor; PIP2: phospho-inositol bisphosphate; PLC: phospholipase-C; DAG: diacyl glycerol; IP3: inositol triphosphate; IP3R: inositol triphosphate receptor; PKC; protein kinase-C; MLCP: myosin light chain phosphatise; MYPT: myosin phosphatase; SR: sarco-endoplasmic reticulum.

The 1991 version of the plume impingement computer program. Volume 1: Description

NASA Technical Reports Server (NTRS)

Bender, Robert L.; Somers, Richard E.; Prendergast, Maurice J.; Clayton, Joseph P.; Smith, Sheldon D.

1991-01-01

The objective of this contract was to continue development of a vacuum plume impingement evaluator to provide an analyst with a capability for rapid assessment of thruster plume impingement scenarios. The research was divided into three areas: Plume Impingement Computer Program (PLIMP) modification/validation; graphics development; and documentation in the form of a Plume Handbook and PLIMP Input Guide.

Computer Recreations.

ERIC Educational Resources Information Center

Dewdney, A. K.

1989-01-01

Discussed are three examples of computer graphics including biomorphs, Truchet tilings, and fractal popcorn. The graphics are shown and the basic algorithm using multiple iteration of a particular function or mathematical operation is described. An illustration of a snail shell created by computer graphics is presented. (YP)

Evaluation of graphic cardiovascular display in a high-fidelity simulator.

PubMed

Agutter, James; Drews, Frank; Syroid, Noah; Westneskow, Dwayne; Albert, Rob; Strayer, David; Bermudez, Julio; Weinger, Matthew B

2003-11-01

"Human error" in anesthesia can be attributed to misleading information from patient monitors or to the physician's failure to recognize a pattern. A graphic representation of monitored data may provide better support for detection, diagnosis, and treatment. We designed a graphic display to show hemodynamic variables. Twenty anesthesiologists were asked to assume care of a simulated patient. Half the participants used the graphic cardiovascular display; the other half used a Datex As/3 monitor. One scenario was a total hip replacement with a transfusion reaction to mismatched blood. The second scenario was a radical prostatectomy with 1.5 L of blood loss and myocardial ischemia. Subjects who used the graphic display detected myocardial ischemia 2 min sooner than those who did not use the display. Treatment was initiated sooner (2.5 versus 4.9 min). There were no significant differences between groups in the hip replacement scenario. Systolic blood pressure deviated less from baseline, central venous pressure was closer to its baseline, and arterial oxygen saturation was higher at the end of the case when the graphic display was used. The study lends some support for the hypothesis that providing clinical information graphically in a display designed with emergent features and functional relationships can improve clinicians' ability to detect, diagnose, manage, and treat critical cardiovascular events in a simulated environment. A graphic representation of monitored data may provide better support for detection, diagnosis, and treatment. A user-centered design process led to a novel object-oriented graphic display of hemodynamic variables containing emergent features and functional relationships. In a simulated environment, this display appeared to support clinicians' ability to diagnose, manage, and treat a critical cardiovascular event in a simulated environment. We designed a graphic display to show hemodynamic variables. The study provides some support for the hypothesis that providing clinical information graphically in a display designed with emergent features and functional relationships can improve clinicians' ability to detect, diagnosis, mange, and treat critical cardiovascular events in a simulated environment.

The Design and Implementation of a Graphical VHDL (VHSIC Hardware Description Language) User Interface

DTIC Science & Technology

1988-12-01

VHSIC Program Office appropriately summarized the motivation behind VHDL as follows: Computer -aided engineering is a nightmare of incompatible formats and... Computer Science Branch. Interactive VHDL Workstation: Program Status Review Report, 8 October 1987. Air Force Contract F33615-85-C-1862. Information Systems...Typical Program Structure .................................. 14 3 Figure 4. GVUI Top-Level SADT Diagram ............................... .24 Figure 5

A user's guide for DTIZE an interactive digitizing and graphical editing computer program

NASA Technical Reports Server (NTRS)

Thomas, C. C.

1981-01-01

A guide for DTIZE, a two dimensional digitizing program with graphical editing capability, is presented. DTIZE provides the capability to simultaneously create and display a picture on the display screen. Data descriptions may be permanently saved in three different formats. DTIZE creates the picture graphics in the locator mode, thus inputting one coordinate each time the terminator button is pushed. Graphic input devices (GIN) are also used to select function command menu. These menu commands and the program's interactive prompting sequences provide a complete capability for creating, editing, and permanently recording a graphical picture file. DTIZE is written in FORTRAN IV language for the Tektronix 4081 graphic system utilizing the Plot 80 Distributed Graphics Library (DGL) subroutines. The Tektronix 4953/3954 Graphic Tablet with mouse, pen, or joystick are used as graphics input devices to create picture graphics.

48 CFR 342.302 - Contract administration functions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... functions. 342.302 Section 342.302 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Administration Office Functions 342.302 Contract administration... services), will take place on HHS-owned or controlled properties. The clause shall not be included if...

48 CFR 342.302 - Contract administration functions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... functions. 342.302 Section 342.302 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Administration Office Functions 342.302 Contract administration... services), will take place on HHS-owned or controlled properties. The clause shall not be included if...

48 CFR 342.302 - Contract administration functions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... functions. 342.302 Section 342.302 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Administration Office Functions 342.302 Contract administration... services), will take place on HHS-owned or controlled properties. The clause shall not be included if...

48 CFR 342.302 - Contract administration functions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... functions. 342.302 Section 342.302 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Contract Administration Office Functions 342.302 Contract administration... services), will take place on HHS-owned or controlled properties. The clause shall not be included if...

A fundamental model of quasi-static wheelchair biomechanics.

PubMed

Leary, M; Gruijters, J; Mazur, M; Subic, A; Burton, M; Fuss, F K

2012-11-01

The performance of a wheelchair system is a function of user anatomy, including arm segment lengths and muscle parameters, and wheelchair geometry, in particular, seat position relative to the wheel hub. To quantify performance, researchers have proposed a number of predictive models. In particular, the model proposed by Richter is extremely useful for providing initial analysis as it is simple to apply and provides insight into the peak and transient joint torques required to achieve a given angular velocity. The work presented in this paper identifies and corrects a critical error; specifically that the Richter model incorrectly predicts that shoulder torque is due to an anteflexing muscle moment. This identified error was confirmed analytically, graphically and numerically. The authors have developed a corrected, fundamental model which identifies that the shoulder anteflexes only in the first half of the push phase and retroflexes in the second half. The fundamental model has been extended by the authors to obtain novel data on joint and net power as a function of push progress. These outcomes indicate that shoulder power is positive in the first half of the push phase (concentrically contracting anteflexors) and negative in the second half (eccentrically contracting retroflexors). As the eccentric contraction introduces adverse negative power, these considerations are essential when optimising wheelchair design in terms of the user's musculoskeletal system. The proposed fundamental model was applied to assess the effect of vertical seat position on joint torques and power. Increasing the seat height increases the peak positive (concentric) shoulder and elbow torques while reducing the associated (eccentric) peak negative torque. Furthermore, the transition from positive to negative shoulder torque (as well as from positive to negative power) occurs later in the push phase with increasing seat height. These outcomes will aid in the optimisation of manual wheelchair propulsion biomechanics by minimising adverse negative muscle power, and allow joint torques to be manipulated as required to minimise injury or aid in rehabilitation. Copyright © 2012. Published by Elsevier Ltd.

REQUIREMENTS FOR GRAPHIC TEACHING MACHINES.

ERIC Educational Resources Information Center

HICKEY, ALBERT; AND OTHERS

AN EXPERIMENT WAS REPORTED WHICH DEMONSTRATES THAT GRAPHICS ARE MORE EFFECTIVE THAN SYMBOLS IN ACQUIRING ALGEBRA CONCEPTS. THE SECOND PHASE OF THE STUDY DEMONSTRATED THAT GRAPHICS IN HIGH SCHOOL TEXTBOOKS WERE RELIABLY CLASSIFIED IN A MATRIX OF 480 FUNCTIONAL STIMULUS-RESPONSE CATEGORIES. SUGGESTIONS WERE MADE FOR EXTENDING THE CLASSIFICATION…

48 CFR 342.302 - Contract administration functions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MANAGEMENT CONTRACT ADMINISTRATION Contract Administration Office Functions 342.302 Contract administration..., contractor employees are considered “visitors.” Further, for any proposed or existing construction contract...

Univariate Probability Distributions

ERIC Educational Resources Information Center

Leemis, Lawrence M.; Luckett, Daniel J.; Powell, Austin G.; Vermeer, Peter E.

2012-01-01

We describe a web-based interactive graphic that can be used as a resource in introductory classes in mathematical statistics. This interactive graphic presents 76 common univariate distributions and gives details on (a) various features of the distribution such as the functional form of the probability density function and cumulative distribution…

An Interactive Graphics Program for Assistance in Learning Convolution.

ERIC Educational Resources Information Center

Frederick, Dean K.; Waag, Gary L.

1980-01-01

A program has been written for the interactive computer graphics facility at Rensselaer Polytechnic Institute that is designed to assist the user in learning the mathematical technique of convolving two functions. Because convolution can be represented graphically by a sequence of steps involving folding, shifting, multiplying, and integration, it…

Teaching Real Business Cycles to Undergraduates

ERIC Educational Resources Information Center

Brevik, Frode; Gartner, Manfred

2007-01-01

The authors review the graphical approach to teaching the real business cycle model introduced in Barro. They then look at where this approach cuts corners and suggest refinements. Finally, they compare graphical and exact models by means of impulse-response functions. The graphical models yield reliable qualitative results. Sizable quantitative…

High Fidelity Images--How They Affect Learning.

ERIC Educational Resources Information Center

Kwinn, Ann

1997-01-01

Discusses the use of graphics in instruction and concludes that cosmetic and motivational graphics can be more realistic and detailed for affective goals, while schematic graphics may be best for the more cognitive functions of focusing attention and presenting actual content. Domains of learning, mental models, and visualization are examined.…

KMWin--a convenient tool for graphical presentation of results from Kaplan-Meier survival time analysis.

PubMed

Gross, Arnd; Ziepert, Marita; Scholz, Markus

2012-01-01

Analysis of clinical studies often necessitates multiple graphical representations of the results. Many professional software packages are available for this purpose. Most packages are either only commercially available or hard to use especially if one aims to generate or customize a huge number of similar graphical outputs. We developed a new, freely available software tool called KMWin (Kaplan-Meier for Windows) facilitating Kaplan-Meier survival time analysis. KMWin is based on the statistical software environment R and provides an easy to use graphical interface. Survival time data can be supplied as SPSS (sav), SAS export (xpt) or text file (dat), which is also a common export format of other applications such as Excel. Figures can directly be exported in any graphical file format supported by R. On the basis of a working example, we demonstrate how to use KMWin and present its main functions. We show how to control the interface, customize the graphical output, and analyse survival time data. A number of comparisons are performed between KMWin and SPSS regarding graphical output, statistical output, data management and development. Although the general functionality of SPSS is larger, KMWin comprises a number of features useful for survival time analysis in clinical trials and other applications. These are for example number of cases and number of cases under risk within the figure or provision of a queue system for repetitive analyses of updated data sets. Moreover, major adjustments of graphical settings can be performed easily on a single window. We conclude that our tool is well suited and convenient for repetitive analyses of survival time data. It can be used by non-statisticians and provides often used functions as well as functions which are not supplied by standard software packages. The software is routinely applied in several clinical study groups.

KMWin – A Convenient Tool for Graphical Presentation of Results from Kaplan-Meier Survival Time Analysis

PubMed Central

Gross, Arnd; Ziepert, Marita; Scholz, Markus

2012-01-01

Background Analysis of clinical studies often necessitates multiple graphical representations of the results. Many professional software packages are available for this purpose. Most packages are either only commercially available or hard to use especially if one aims to generate or customize a huge number of similar graphical outputs. We developed a new, freely available software tool called KMWin (Kaplan-Meier for Windows) facilitating Kaplan-Meier survival time analysis. KMWin is based on the statistical software environment R and provides an easy to use graphical interface. Survival time data can be supplied as SPSS (sav), SAS export (xpt) or text file (dat), which is also a common export format of other applications such as Excel. Figures can directly be exported in any graphical file format supported by R. Results On the basis of a working example, we demonstrate how to use KMWin and present its main functions. We show how to control the interface, customize the graphical output, and analyse survival time data. A number of comparisons are performed between KMWin and SPSS regarding graphical output, statistical output, data management and development. Although the general functionality of SPSS is larger, KMWin comprises a number of features useful for survival time analysis in clinical trials and other applications. These are for example number of cases and number of cases under risk within the figure or provision of a queue system for repetitive analyses of updated data sets. Moreover, major adjustments of graphical settings can be performed easily on a single window. Conclusions We conclude that our tool is well suited and convenient for repetitive analyses of survival time data. It can be used by non-statisticians and provides often used functions as well as functions which are not supplied by standard software packages. The software is routinely applied in several clinical study groups. PMID:22723912

A review of contemporary methods for the presentation of scientific uncertainty.

PubMed

Makinson, K A; Hamby, D M; Edwards, J A

2012-12-01

Graphic methods for displaying uncertainty are often the most concise and informative way to communicate abstract concepts. Presentation methods currently in use for the display and interpretation of scientific uncertainty are reviewed. Numerous subjective and objective uncertainty display methods are presented, including qualitative assessments, node and arrow diagrams, standard statistical methods, box-and-whisker plots,robustness and opportunity functions, contribution indexes, probability density functions, cumulative distribution functions, and graphical likelihood functions.

The graphics calculator in mathematics education: A critical review of recent research

NASA Astrophysics Data System (ADS)

Penglase, Marina; Arnold, Stephen

1996-04-01

The graphics calculator, sometimes referred to as the "super calculator," has sparked great interest among mathematics educators. Considered by many to be a tool which has the potential to revolutionise mathematics education, a significant amount of research has been conducted into its effectiveness as a tool for instruction and learning within precalculus and calculus courses, specifically in the study of functions, graphing and modelling. Some results suggest that these devices (a) can facilitate the learning of functions and graphing concepts and the development of spatial visualisation skills; (b) promote mathematical investigation and exploration; and (c) encourage a shift in emphasis from algebraic manipulation and proof to graphical investigation and examination of the relationship between graphical, algebraic and geometric representations. Other studies, however, indicate that there is still a need for manipulative techniques in the learning of function and graphing concepts, that the use of graphics calculators may not facilitate the learning of particular precalculus topics, and that some "de-skilling" may occur, especially among males. It is the contention of this paper, however, that much of the research in this new and important field fails to provide clear guidance or even to inform debate in adequate ways regarding the role of graphics calculators in mathematics teaching and learning. By failing to distinguish the role of the tool from that of the instructional process, many studies reviewed could be more appropriately classified as "program evaluations" rather than as research on the graphics calculator per se. Further, claims regarding the effectiveness of the graphics calculator as a tool for learning frequently fail to recognise that judgments of effectiveness result directly from existing assumptions regarding both assessment practice and student "achievement."

The application of interactive graphics to large time-dependent hydrodynamics problems

NASA Technical Reports Server (NTRS)

Gama-Lobo, F.; Maas, L. D.

1975-01-01

A written companion of a movie entitled "Interactive Graphics at Los Alamos Scientific Laboratory" was presented. While the movie presents the actual graphics terminal and the functions performed on it, the paper attempts to put in perspective the complexity of the application code and the complexity of the interaction that is possible.

The Effectiveness of Graphic Organizers to Support Executive Function for Ninth Grade Struggling Readers

ERIC Educational Resources Information Center

Barry, Elaine

2016-01-01

Struggling readers, or students who read below grade level but have strong phonological awareness, may benefit from using instructional tools like graphic organizers (GOs) while reading. The purpose of this study was to investigate the relationship between reading comprehension and teacher-generated graphic organizers (GOs) as they support…

77 FR 12888 - International Mail Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... instant contract is functionally equivalent to the IBRS 3 baseline contract originally filed in Docket Nos... product, also authorized functionally equivalent agreements to be included within the product, provided... Service Filing of a Functionally Equivalent International Business Reply Service Competitive Contract 3...

A Visualisation-Based Semiotic Analysis of Learners' Conceptual Understanding of Graphical Functional Relationships

ERIC Educational Resources Information Center

Mudaly, Vimolan

2014-01-01

Within the South African school curriculum, the section on graphical functional relationships consists of signs which include symbols, notation and imagery. In a previous article we explored the role visualisation played in the way learners understood mathematical concepts. That paper reported on the learners' fixation with the physical features…

A Prototype Lisp-Based Soft Real-Time Object-Oriented Graphical User Interface for Control System Development

NASA Technical Reports Server (NTRS)

Litt, Jonathan; Wong, Edmond; Simon, Donald L.

1994-01-01

A prototype Lisp-based soft real-time object-oriented Graphical User Interface for control system development is presented. The Graphical User Interface executes alongside a test system in laboratory conditions to permit observation of the closed loop operation through animation, graphics, and text. Since it must perform interactive graphics while updating the screen in real time, techniques are discussed which allow quick, efficient data processing and animation. Examples from an implementation are included to demonstrate some typical functionalities which allow the user to follow the control system's operation.

Development of the ultrastructure of sonic muscles: a kind of neoteny?

PubMed Central

2014-01-01

Background Drumming muscles of some sound-producing fish are ‘champions’ of contraction speed, their rate setting the fundamental frequency. In the piranha, contraction of these muscles at 150 Hz drives a sound at the same frequency. Drumming muscles of different not closely related species show evolutionary convergences. Interestingly, some characters of sonic muscles can also be found in the trunk muscles of newly hatched larvae that are able to maintain tail beat frequencies up to 100 Hz. The aim of this work was to study the development of sound production and sonic and epaxial muscles simultaneously in the red bellied piranhas (Pygocentrus nattereri) to seek for possible common characteristics. Results Call, pulse and period durations increased significantly with the fish size, but the call dominant frequencies decreased, and the number of pulses and the call amplitude formed a bell curve. In epaxial muscles, the fibre diameters of younger fish are first positioned in the graphical slope corresponding to sonic muscles, before diverging. The fibre diameter of older fish trunk muscles was bigger, and the area of the myofibrils was larger than in sonic muscles. Moreover, in two of the biggest fish, the sonic muscles were invaded by fat cells and the sonic muscle ultrastructure was similar to the epaxial one. These two fish were also unable to produce any sound, meaning they lost their ability to contract quickly. Conclusions The volume occupied by myofibrils determines the force of contraction, the volume of sarcoplasmic reticulum sets the contraction frequency, and the volume of mitochondria sets the level of sustained performance. The functional outcomes in muscles are all attributable to shifts in the proportions of those structures. A single delay in the development restricts the quantity of myofibrils, maintains a high proportion of space in the sarcoplasm and develops sarcoplasmic reticulum. High-speed sonic muscles could thus be skeletal muscles with delayed development. This hypothesis has the advantage that it could easily explain why high-speed sonic muscles have evolved so many times in different lineages. PMID:24507247

Structural and Functional Model of Organization of Geometric and Graphic Training of the Students

ERIC Educational Resources Information Center

Poluyanov, Valery B.; Pyankova, Zhanna A.; Chukalkina, Marina I.; Smolina, Ekaterina S.

2016-01-01

The topicality of the investigated problem is stipulated by the social need for training competitive engineers with a high level of graphical literacy; especially geometric and graphic training of students and its projected results in a competence-based approach; individual characteristics and interests of the students, as well as methodological…

Young Children and Turtle Graphics Programming: Generating and Debugging Simple Turtle Programs.

ERIC Educational Resources Information Center

Cuneo, Diane O.

Turtle graphics is a popular vehicle for introducing children to computer programming. Children combine simple graphic commands to get a display screen cursor (called a turtle) to draw designs on the screen. The purpose of this study was to examine young children's abilities to function in a simple computer programming environment. Four- and…

The Concurrent Engineering Design Paradigm Is Now Fully Functional for Graphics Education

ERIC Educational Resources Information Center

Krueger, Thomas J.; Barr, Ronald E.

2007-01-01

Engineering design graphics education has come a long way in the past two decades. The emergence of solid geometric modeling technology has become the focal point for the graphical development of engineering design ideas. The main attraction of this 3-D modeling approach is the downstream application of the data base to analysis and…

L3 Interactive Data Language

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hohn, Michael; Adams, Paul

2006-09-05

The L3 system is a computational steering environment for image processing and scientific computing. It consists of an interactive graphical language and interface. Its purpose is to help advanced users in controlling their computational software and assist in the management of data accumulated during numerical experiments. L3 provides a combination of features not found in other environments; these are: - textual and graphical construction of programs - persistence of programs and associated data - direct mapping between the scripts, the parameters, and the produced data - implicit hierarchial data organization - full programmability, including conditionals and functions - incremental executionmore » of programs The software includes the l3 language and the graphical environment. The language is a single-assignment functional language; the implementation consists of lexer, parser, interpreter, storage handler, and editing support, The graphical environment is an event-driven nested list viewer/editor providing graphical elements corresponding to the language. These elements are both the represenation of a users program and active interfaces to the values computed by that program.« less

The Capabilities of the Graphical Observation Scheduling System (GROSS) as Used by the Astro-2 Spacelab Mission

NASA Technical Reports Server (NTRS)

Phillips, Shaun

1996-01-01

The Graphical Observation Scheduling System (GROSS) and its functionality and editing capabilities are reported on. The GROSS system was developed as a replacement for a suite of existing programs and associated processes with the aim of: providing a software tool that combines the functionality of several of the existing programs, and provides a Graphical User Interface (GUI) that gives greater data visibility and editing capabilities. It is considered that the improved editing capability provided by this approach enhanced the efficiency of the second astronomical Spacelab mission's (ASTRO-2) mission planning.

Using Task Clarification, Graphic Feedback, and Verbal Feedback to Increase Closing-Task Completion in a Privately Owned Restaurant.

ERIC Educational Resources Information Center

Austin, John; Weatherly, Nic L.; Gravina, Nicole E.

2005-01-01

An informant functional assessment was used to evaluate closing-task completion by servers and dishwashers at a restaurant. Based on the functional assessment results, an intervention consisting of task clarification, posted graphic feedback, and verbal feedback was implemented and evaluated with a multiple baseline design across two groups of…

Mathematical Investigations Using Logo. Part Two.

ERIC Educational Resources Information Center

Brown, Ken

1986-01-01

Programs (using Logo) developed by children to produce multiples, the Fibonacci series, and square numbers are presented, with graphical representations of functions introduced. Another investigation involves drawing a circle using turtle graphics. (MNS)

An Argument for the Keyhole Template for Close Air Support on the Urban Battlefield

DTIC Science & Technology

2009-03-04

An Argument for the Keyhole Template for Close Air Support on the Urban Battlefield Captain BT Taggart Major RC... Keyhole Template for Close Air Support on the Urban Battlefield 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...graphic (GRG). Using the target building as the keyhole , or center of the engagement area, Lightning 62 requested a laser guided Maverick to destroy

A visual analysis of multi-attribute data using pixel matrix displays

NASA Astrophysics Data System (ADS)

Hao, Ming C.; Dayal, Umeshwar; Keim, Daniel; Schreck, Tobias

2007-01-01

Charts and tables are commonly used to visually analyze data. These graphics are simple and easy to understand, but charts show only highly aggregated data and present only a limited number of data values while tables often show too many data values. As a consequence, these graphics may either lose or obscure important information, so different techniques are required to monitor complex datasets. Users need more powerful visualization techniques to digest and compare detailed multi-attribute data to analyze the health of their business. This paper proposes an innovative solution based on the use of pixel-matrix displays to represent transaction-level information. With pixelmatrices, users can visualize areas of importance at a glance, a capability not provided by common charting techniques. We present our solutions to use colored pixel-matrices in (1) charts for visualizing data patterns and discovering exceptions, (2) tables for visualizing correlations and finding root-causes, and (3) time series for visualizing the evolution of long-running transactions. The solutions have been applied with success to product sales, Internet network performance analysis, and service contract applications demonstrating the benefits of our method over conventional graphics. The method is especially useful when detailed information is a key part of the analysis.

Brain Activity Associated with Translation between Graphical and Symbolic Representations of Functions in Generally Gifted and Excelling in Mathematics Adolescents

ERIC Educational Resources Information Center

Waisman, Ilana; Leikin, Mark; Shaul, Shelley; Leikin, Roza

2014-01-01

In this study, we examine the impact and the interplay of general giftedness (G) and excellence in mathematics (EM) on high school students' mathematical performance associated with translations from graphical to symbolic representations of functions, as reflected in cortical electrical activity (by means of ERP--event-related…

Agreement in functional assessment: graphic approaches to displaying respondent effects.

PubMed

Haley, Stephen M; Ni, Pengsheng; Coster, Wendy J; Black-Schaffer, Randie; Siebens, Hilary; Tao, Wei

2006-09-01

The objective of this study was to examine the agreement between respondents of summary scores from items representing three functional content areas (physical and mobility, personal care and instrumental, applied cognition) within the Activity Measure for Postacute Care (AM-PAC). We compare proxy vs. patient report in both hospital and community settings as represented by intraclass correlation coefficients and two graphic approaches. The authors conducted a prospective, cohort study of a convenience sample of adults (n = 47) receiving rehabilitation services either in hospital (n = 31) or community (n = 16) settings. In addition to using intraclass correlation coefficients (ICC) as indices of agreement, we applied two graphic approaches to serve as complements to help interpret the direction and magnitude of respondent disagreements. We created a "mountain plot" based on a cumulative distribution curve and a "survival-agreement plot" with step functions used in the analysis of survival data. ICCs on summary scores between patient and proxy report were physical and mobility ICC = 0.92, personal care and instrumental ICC = 0.93, and applied cognition ICC = 0.77. Although combined respondent agreement was acceptable, graphic approaches helped interpret differences in separate analyses of clinician and family agreement. Graphic analyses allow for a simple interpretation of agreement data and may be useful in determining the meaningfulness of the amount and direction of interrespondent variation.

Microcomputer spacecraft thermal analysis routines (MSTAR) Phase I: The user interface

DOE Office of Scientific and Technical Information (OSTI.GOV)

Teti, N.M.

1993-12-31

The Microcomputer Spacecraft Thermal Analysis Routines (MSTAR) software package is being developed for NASA/Goddard Space Flight Center by Swales and Associates, Inc. (S&AI). In December 1992, S&AI was awarded a phase I Small Business Inovative Research contract fronm NASA to develop a microcomputer based thermal analysis program to replace the current SSPTA and TRASYS programs. Phase I consists of a six month effort which will focus on developing geometric model generation and visualization capabilities using a graphical user interface (GUI). The information contained in this paper encompasses the work performed during the Phase I development cycle; with emphasis on themore » development of the graphical user interface (GUI). This includes both the theory behind and specific examples of how the MSTAR GUI was implemented. Furthermore, this report discusses new applications and enhancements which will improve the capabilities and commercialization of the MSTAR program.« less

Microcomputer spacecraft thermal analysis routines (MSTAR) Phase I: The user interface

NASA Technical Reports Server (NTRS)

Teti, Nicholas M.

1993-01-01

The Microcomputer Spacecraft Thermal Analysis Routines (MSTAR) software package is being developed for NASA/Goddard Space Flight Center by Swales and Associates, Inc. (S&AI). In December 1992, S&AI was awarded a phase I Small Business Inovative Research contract fronm NASA to develop a microcomputer based thermal analysis program to replace the current SSPTA and TRASYS programs. Phase I consists of a six month effort which will focus on developing geometric model generation and visualization capabilities using a graphical user interface (GUI). The information contained in this paper encompasses the work performed during the Phase I development cycle; with emphasis on the development of the graphical user interface (GUI). This includes both the theory behind and specific examples of how the MSTAR GUI was implemented. Furthermore, this report discusses new applications and enhancements which will improve the capabilities and commercialization of the MSTAR program.

Design and validation of an improved graphical user interface with the 'Tool ball'.

PubMed

Lee, Kuo-Wei; Lee, Ying-Chu

2012-01-01

The purpose of this research is introduce the design of an improved graphical user interface (GUI) and verifies the operational efficiency of the proposed interface. Until now, clicking the toolbar with the mouse is the usual way to operate software functions. In our research, we designed an improved graphical user interface - a tool ball that is operated by a mouse wheel to perform software functions. Several experiments are conducted to measure the time needed to operate certain software functions with the traditional combination of "mouse click + tool button" and the proposed integration of "mouse wheel + tool ball". The results indicate that the tool ball design can accelerate the speed of operating software functions, decrease the number of icons on the screen, and enlarge the applications of the mouse wheel. Copyright © 2011 Elsevier Ltd and The Ergonomics Society. All rights reserved.

INCA- INTERACTIVE CONTROLS ANALYSIS

NASA Technical Reports Server (NTRS)

Bauer, F. H.

1994-01-01

The Interactive Controls Analysis (INCA) program was developed to provide a user friendly environment for the design and analysis of linear control systems, primarily feedback control systems. INCA is designed for use with both small and large order systems. Using the interactive graphics capability, the INCA user can quickly plot a root locus, frequency response, or time response of either a continuous time system or a sampled data system. The system configuration and parameters can be easily changed, allowing the INCA user to design compensation networks and perform sensitivity analysis in a very convenient manner. A journal file capability is included. This stores an entire sequence of commands, generated during an INCA session into a file which can be accessed later. Also included in INCA are a context-sensitive help library, a screen editor, and plot windows. INCA is robust to VAX-specific overflow problems. The transfer function is the basic unit of INCA. Transfer functions are automatically saved and are available to the INCA user at any time. A powerful, user friendly transfer function manipulation and editing capability is built into the INCA program. The user can do all transfer function manipulations and plotting without leaving INCA, although provisions are made to input transfer functions from data files. By using a small set of commands, the user may compute and edit transfer functions, and then examine these functions by using the ROOT_LOCUS, FREQUENCY_RESPONSE, and TIME_RESPONSE capabilities. Basic input data, including gains, are handled as single-input single-output transfer functions. These functions can be developed using the function editor or by using FORTRAN- like arithmetic expressions. In addition to the arithmetic functions, special functions are available to 1) compute step, ramp, and sinusoid functions, 2) compute closed loop transfer functions, 3) convert from S plane to Z plane with optional advanced Z transform, and 4) convert from Z plane to W plane and back. These capabilities allow the INCA user to perform block diagram algebraic manipulations quickly for functions in the S, Z, and W domains. Additionally, a versatile digital control capability has been included in INCA. Special plane transformations allow the user to easily convert functions from one domain to another. Other digital control capabilities include: 1) totally independent open loop frequency response analyses on a continuous plant, discrete control system with a delay, 2) advanced Z-transform capability for systems with delays, and 3) multirate sampling analyses. The current version of INCA includes Dynamic Functions (which change when a parameter changes), standard filter generation, PD and PID controller generation, incorporation of the QZ-algorithm (function addition, inverse Laplace), and describing functions that allow the user to calculate the gain and phase characteristics of a nonlinear device. The INCA graphic modes provide the user with a convenient means to document and study frequency response, time response, and root locus analyses. General graphics features include: 1) zooming and dezooming, 2) plot documentation, 3) a table of analytic computation results, 4) multiple curves on the same plot, and 5) displaying frequency and gain information for a specific point on a curve. Additional capabilities in the frequency response mode include: 1) a full complement of graphical methods Bode magnitude, Bode phase, Bode combined magnitude and phase, Bode strip plots, root contour plots, Nyquist, Nichols, and Popov plots; 2) user selected plot scaling; and 3) gain and phase margin calculation and display. In the time response mode, additional capabilities include: 1) support for inverse Laplace and inverse Z transforms, 2) support for various input functions, 3) closed loop response evaluation, 4) loop gain sensitivity analyses, 5) intersample time response for discrete systems using the advanced Z transform, and 6) closed loop time response using mixed plane (S, Z, W) operations with delay. A Graphics mode command was added to the current version of INCA, version 3.13, to produce Metafiles (graphic files) of the currently displayed plot. The metafile can be displayed and edited using the QPLOT Graphics Editor and Replotter for Metafiles (GERM) program included with the INCA package. The INCA program is written in Pascal and FORTRAN for interactive or batch execution and has been implemented on a DEC VAX series computer under VMS. Both source code and executable code are supplied for INCA. Full INCA graphics capabilities are supported for various Tektronix 40xx and 41xx terminals; DEC VT graphics terminals; many PC and Macintosh terminal emulators; TEK014 hardcopy devices such as the LN03 Laserprinter; and bit map graphics external hardcopy devices. Also included for the TEK4510 rasterizer users are a multiple copy feature, a wide line feature, and additional graphics fonts. The INCA program was developed in 1985, Version 2.04 was released in 1986, Version 3.00 was released in 1988, and Version 3.13 was released in 1989. An INCA version 2.0X conversion program is included.

Internal wave energy flux from density perturbations in nonlinear stratifications

NASA Astrophysics Data System (ADS)

Lee, Frank M.; Allshouse, Michael R.; Swinney, Harry L.; Morrison, P. J.

2017-11-01

Tidal flow over the topography at the bottom of the ocean, whose density varies with depth, generates internal gravity waves that have a significant impact on the energy budget of the ocean. Thus, understanding the energy flux (J = p v) is important, but it is difficult to measure simultaneously the pressure and velocity perturbation fields, p and v . In a previous work, a Green's-function-based method was developed to calculate the instantaneous p, v , and thus J , given a density perturbation field for a constant buoyancy frequency N. Here we extend the previous analytic Green's function work to include nonuniform N profiles, namely the tanh-shaped and linear cases, because background density stratifications that occur in the ocean and some experiments are nonlinear. In addition, we present a finite-difference method for the general case where N has an arbitrary profile. Each method is validated against numerical simulations. The methods we present can be applied to measured density perturbation data by using our MATLAB graphical user interface EnergyFlux. PJM was supported by the U.S. Department of Energy Contract DE-FG05-80ET-53088. HLS and MRA were supported by ONR Grant No. N000141110701.

Network Control Center User Planning System (NCC UPS)

NASA Astrophysics Data System (ADS)

Dealy, Brian

1991-09-01

NCC UPS is presented in the form of the viewgraphs. The following subject areas are covered: UPS overview; NCC UPS role; major NCC UPS functional requirements; interactive user access levels; UPS interfaces; interactive user subsystem; interface navigation; scheduling screen hierarchy; interactive scheduling input panels; autogenerated schedule request panel; schedule data tabular display panel; schedule data graphic display panel; graphic scheduling aid design; and schedule data graphic display.

Network Control Center User Planning System (NCC UPS)

NASA Technical Reports Server (NTRS)

Dealy, Brian

1991-01-01

NCC UPS is presented in the form of the viewgraphs. The following subject areas are covered: UPS overview; NCC UPS role; major NCC UPS functional requirements; interactive user access levels; UPS interfaces; interactive user subsystem; interface navigation; scheduling screen hierarchy; interactive scheduling input panels; autogenerated schedule request panel; schedule data tabular display panel; schedule data graphic display panel; graphic scheduling aid design; and schedule data graphic display.

Network, system, and status software enhancements for the autonomously managed electrical power system breadboard. Volume 4: Graphical status display

NASA Technical Reports Server (NTRS)

Mckee, James W.

1990-01-01

This volume (4 of 4) contains the description, structured flow charts, prints of the graphical displays, and source code to generate the displays for the AMPS graphical status system. The function of these displays is to present to the manager of the AMPS system a graphical status display with the hot boxes that allow the manager to get more detailed status on selected portions of the AMPS system. The development of the graphical displays is divided into two processes; the creation of the screen images and storage of them in files on the computer, and the running of the status program which uses the screen images.

Effects of computer-based graphic organizers to solve one-step word problems for middle school students with mild intellectual disability: A preliminary study.

PubMed

Sheriff, Kelli A; Boon, Richard T

2014-08-01

The purpose of this study was to examine the effects of computer-based graphic organizers, using Kidspiration 3© software, to solve one-step word problems. Participants included three students with mild intellectual disability enrolled in a functional academic skills curriculum in a self-contained classroom. A multiple probe single-subject research design (Horner & Baer, 1978) was used to evaluate the effectiveness of computer-based graphic organizers to solving mathematical one-step word problems. During the baseline phase, the students completed a teacher-generated worksheet that consisted of nine functional word problems in a traditional format using a pencil, paper, and a calculator. In the intervention and maintenance phases, the students were instructed to complete the word problems using a computer-based graphic organizer. Results indicated that all three of the students improved in their ability to solve the one-step word problems using computer-based graphic organizers compared to traditional instructional practices. Limitations of the study and recommendations for future research directions are discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

Perceptions and Performance of King Saud University Students' about Concept and Finding Limit of Functions Graphical and Symbolic

ERIC Educational Resources Information Center

El-khateeb, Mahmoud M. A.

2015-01-01

The purpose of this study was to investigate the misperceptions and performance of king Saud University students' about concept and finding the limit of same partial functions given in the form of both graphical and symbolic. In the collection of the data, the researcher employed the open-ended question test consisted of four items. Firstly,…

The Effects of the Use of Microsoft Math Tool (Graphical Calculator) Instruction on Students' Performance in Linear Functions

ERIC Educational Resources Information Center

Kissi, Philip Siaw; Opoku, Gyabaah; Boateng, Sampson Kwadwo

2016-01-01

The aim of the study was to investigate the effect of Microsoft Math Tool (graphical calculator) on students' achievement in the linear function. The study employed Quasi-experimental research design (Pre-test Post-test two group designs). A total of ninety-eight (98) students were selected for the study from two different Senior High Schools…

High Speed Modulation, Beam Steering and Control of High Power Diode Lasers

DTIC Science & Technology

2000-03-03

designing the interactive simulator in such a way that the user will be able to probe the system and change parameters on the fly. Pull -down menus will...AR and HR coatings, beam splitters, external cavities, etc) can be built and accessed via pull -down menus within an optical systems graphical GUI...supported in part by the National Science Foundation’s GOALI program under grant number DM59811466 and AFOSR under contract number F49620-97-1-0002 and

42 CFR 421.200 - Carrier functions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 3 2010-10-01 2010-10-01 false Carrier functions. 421.200 Section 421.200 Public...) MEDICARE PROGRAM MEDICARE CONTRACTING Carriers § 421.200 Carrier functions. A contract between CMS and a carrier specifies the functions to be performed by the carrier. The contract may include any or all of the...

Computer graphics for quality control in the INAA of geological samples

USGS Publications Warehouse

Grossman, J.N.; Baedecker, P.A.

1987-01-01

A data reduction system for the routine instrumental activation analysis of samples is described, with particular emphasis on interactive graphics capabilities for evaluating analytical quality. Graphics procedures have been developed to interactively control the analysis of selected photopeaks during spectral analysis, and to evaluate detector performance during a given counting cycle. Graphics algorithms are also used to compare the data on reference samples with accepted values, to prepare quality control charts to evaluate long term precision and to search for systematic variations in data on reference samples as a function of time. ?? 1987 Akade??miai Kiado??.

Cognitive-graphic method for constructing of hierarchical forms of basic functions of biquadratic finite element

NASA Astrophysics Data System (ADS)

Astionenko, I. O.; Litvinenko, O. I.; Osipova, N. V.; Tuluchenko, G. Ya.; Khomchenko, A. N.

2016-10-01

Recently the interpolation bases of the hierarchical type have been used for the problem solving of the approximation of multiple arguments functions (such as in the finite-element method). In this work the cognitive graphical method of constructing of the hierarchical form bases on the serendipity finite elements is suggested, which allowed to get the alternative bases on a biquadratic finite element from the serendipity family without internal knots' inclusion. The cognitive-graphic method allowed to improve the known interpolation procedure of Taylor and to get the modified elements with irregular arrangement of knots. The proposed procedures are universal and are spread in the area of finite-elements.

Teaching Linear Functions in Context with Graphics Calculators: Students' Responses and the Impact of the Approach on Their Use of Algebraic Symbols

ERIC Educational Resources Information Center

Bardini, Caroline; Pierce, Robyn U.; Stacey, Kaye

2004-01-01

This study analyses some of the consequences of adopting a functional/modelling approach to the teaching of algebra. The teaching of one class of 17 students was observed over five weeks, with 15 students undertaking both pre- and post-tests and 6 students and the teacher being interviewed individually. Use of graphics calculators made the…

CASE/A - COMPUTER AIDED SYSTEM ENGINEERING AND ANALYSIS, ECLSS/ATCS SERIES

NASA Technical Reports Server (NTRS)

Bacskay, A.

1994-01-01

Design and analysis of Environmental Control and Life Support Systems (ECLSS) and Active Thermal Control Systems (ATCS) for spacecraft missions requires powerful software that is flexible and responsive to the demands of particular projects. CASE/A is an interactive trade study and analysis tool designed to increase productivity during all phases of systems engineering. The graphics-based command-driven package provides a user-friendly environment in which the engineer can analyze the performance and interface characteristics of an ECLS/ATC system. The package is useful during all phases of a spacecraft design program, from initial conceptual design trade studies to the actual flight, including pre-flight prediction and in-flight anomaly analysis. The CASE/A program consists of three fundamental parts: 1) the schematic management system, 2) the database management system, and 3) the simulation control and execution system. The schematic management system allows the user to graphically construct a system model by arranging icons representing system components and connecting the components with physical fluid streams. Version 4.1 contains 51 fully coded and documented default component routines. New components can be added by the user through the "blackbox" component option. The database management system supports the storage and manipulation of component data, output data, and solution control data through interactive edit screens. The simulation control and execution system initiates and controls the iterative solution process, displaying time status and any necessary diagnostic messages. In addition to these primary functions, the program provides three other important functional areas: 1) model output management, 2) system utility commands, and 3) user operations logic capacity. The model output management system provides tabular and graphical output capability. Complete fluid constituent mass fraction and properties data (mass flow, pressure, temperature, specific heat, density, and viscosity) is generated at user-selected output intervals and stored for reference. The Integrated Plot Utility (IPU) provides plotting capability for all data output. System utility commands are provided to enable the user to operate more efficiently in the CASE/A environment. The user is able to customize a simulation through optional operations FORTRAN logic. This user-developed code is compiled and linked with a CASE/A model and enables the user to control and timeline component operating parameters during various phases of the iterative solution process. CASE/A provides for transient tracking of the flow stream constituents and determination of their thermodynamic state throughout an ECLSS/ATCS simulation, performing heat transfer, chemical reaction, mass/energy balance, and system pressure drop analysis based on user-specified operating conditions. The program tracks each constituent through all combination and decomposition states while maintaining a mass and energy balance on the overall system. This allows rapid assessment of ECLSS designs, the impact of alternate technologies, and impacts due to changes in metabolic forcing functions, consumables usage, and system control considerations. CASE/A is written in FORTRAN 77 for the DEC VAX/VMS computer series, and requires 12Mb of disk storage and a minimum paging file quota of 20,000 pages. The program operates on the Tektronix 4014 graphics standard and VT100 text standard. The program requires a Tektronix 4014 or later graphics terminal, third party composite graphics/text terminal, or personal computer loaded with appropriate VT100/TEK 4014 emulator software. The use of composite terminals or personal computers with popular emulation software is recommended for enhanced CASE/A operations and general ease of use. The program is available on an unlabeled 9-track 6250 BPI DEC VAX BACKUP format magnetic tape. CASE/A development began in 1985 under contract to NASA/Marshall Space Flight Center. The latest version (4.1) was released in 1990. Tektronix and TEK 4014 are trademarks of Tektronix, Inc. VT100 is a trademark of Digital Equipment Corporation.

Geometric database maintenance using CCTV cameras and overlay graphics

NASA Astrophysics Data System (ADS)

Oxenberg, Sheldon C.; Landell, B. Patrick; Kan, Edwin

1988-01-01

An interactive graphics system using closed circuit television (CCTV) cameras for remote verification and maintenance of a geometric world model database has been demonstrated in GE's telerobotics testbed. The database provides geometric models and locations of objects viewed by CCTV cameras and manipulated by telerobots. To update the database, an operator uses the interactive graphics system to superimpose a wireframe line drawing of an object with known dimensions on a live video scene containing that object. The methodology used is multipoint positioning to easily superimpose a wireframe graphic on the CCTV image of an object in the work scene. An enhanced version of GE's interactive graphics system will provide the object designation function for the operator control station of the Jet Propulsion Laboratory's telerobot demonstration system.

76 FR 36583 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... Docket No. CP2010-36 serve as the baseline contract for future functional equivalence analyses of the... commitments, do not alter the contract's functional equivalency. Id. at 4. The Postal Service asserts that... offered or the fundamental structure of the contract. Therefore, it requests that the instant contract be...

75 FR 69715 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-15

... contract for future functional equivalence analyses of the GEPS 3 product. \\1\\ Notice of United States... GEPS contracts, a description of applicable GEPS contracts, formulas for prices, an analysis of the... information and volume commitments, do not alter the contracts' functional equivalency. Id. at 3-4. The Postal...

OpenSesame: an open-source, graphical experiment builder for the social sciences.

PubMed

Mathôt, Sebastiaan; Schreij, Daniel; Theeuwes, Jan

2012-06-01

In the present article, we introduce OpenSesame, a graphical experiment builder for the social sciences. OpenSesame is free, open-source, and cross-platform. It features a comprehensive and intuitive graphical user interface and supports Python scripting for complex tasks. Additional functionality, such as support for eyetrackers, input devices, and video playback, is available through plug-ins. OpenSesame can be used in combination with existing software for creating experiments.

78 FR 7821 - Public Availability of Railroad Retirement Board FY 2012 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

.../files/omb/procurement/memo/service-contract-inventory-guidance.pdf . The Railroad Retirement Board has... analysis of its selected special interest functions from the FY 2012 Service Contract inventory, and finally (4) the analysis report on its FY 2011 Service Contract Inventory special interest functions, on...

Graphical Environment Tools for Application to Gamma-Ray Energy Tracking Arrays

DOE Office of Scientific and Technical Information (OSTI.GOV)

Todd, Richard A.; Radford, David C.

2013-12-30

Highly segmented, position-sensitive germanium detector systems are being developed for nuclear physics research where traditional electronic signal processing with mixed analog and digital function blocks would be enormously complex and costly. Future systems will be constructed using pipelined processing of high-speed digitized signals as is done in the telecommunications industry. Techniques which provide rapid algorithm and system development for future systems are desirable. This project has used digital signal processing concepts and existing graphical system design tools to develop a set of re-usable modular functions and libraries targeted for the nuclear physics community. Researchers working with complex nuclear detector arraysmore » such as the Gamma-Ray Energy Tracking Array (GRETA) have been able to construct advanced data processing algorithms for implementation in field programmable gate arrays (FPGAs) through application of these library functions using intuitive graphical interfaces.« less

Effective correlator for RadioAstron project

NASA Astrophysics Data System (ADS)

Sergeev, Sergey

This paper presents the implementation of programme FX-correlator for Very Long Baseline Interferometry, adapted for the project "RadioAstron". Software correlator implemented for heterogeneous computing systems using graphics accelerators. It is shown that for the task interferometry implementation of the graphics hardware has a high efficiency. The host processor of heterogeneous computing system, performs the function of forming the data flow for graphics accelerators, the number of which corresponds to the number of frequency channels. So, for the Radioastron project, such channels is seven. Each accelerator is perform correlation matrix for all bases for a single frequency channel. Initial data is converted to the floating-point format, is correction for the corresponding delay function and computes the entire correlation matrix simultaneously. Calculation of the correlation matrix is performed using the sliding Fourier transform. Thus, thanks to the compliance of a solved problem for architecture graphics accelerators, managed to get a performance for one processor platform Kepler, which corresponds to the performance of this task, the computing cluster platforms Intel on four nodes. This task successfully scaled not only on a large number of graphics accelerators, but also on a large number of nodes with multiple accelerators.

Partitioning of Function in a Distributed Graphics System.

DTIC Science & Technology

1985-03-01

Interface specification ( VDI ) is yet another graphi:s standardization effort of ANSI committee X31133 [7]. As shown in figure 2-2, the Virtual Device... VDI specification could be realized in a real device, or at least a "black box" which the user treats as a hardware device. ’he device drivers would...be written by the manufacturer of the graphics device, instead of the author of the graphics system. Since the VDI specification is precisely defined

Squeezing and its graphical representations in the anharmonic oscillator model

NASA Astrophysics Data System (ADS)

Tanaś, R.; Miranowicz, A.; Kielich, S.

1991-04-01

The problem of squeezing and its graphical representations in the anharmonic oscillator model is considered. Explicit formulas for squeezing, principal squeezing, and the quasiprobability distribution (QPD) function are given and illustrated graphically. Approximate analytical formulas for the variances, extremal variances, and QPD are obtained for the case of small nonlinearities and large numbers of photons. The possibility of almost perfect squeezing in the model is demonstrated and its graphical representations in the form of variance lemniscates and QPD contours are plotted. For large numbers of photons the crescent shape of the QPD contours is hardly visible and quite regular ellipses are obtained.

48 CFR 1846.470 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACT MANAGEMENT QUALITY ASSURANCE Government Contract Quality Assurance 1846.470 Contract clause. The contracting officer may insert a clause substantially as stated at 1852.246-71, Government Contract Quality Assurance Functions, in solicitations and contracts to specify the location(s) of quality assurance...

Using Task Clarification, Graphic Feedback, And Verbal Feedback To Increase Closing-Task Completion In A Privately Owned Restaurant

PubMed Central

Weatherly, Nic L; Gravina, Nicole E

2005-01-01

An informant functional assessment was used to evaluate closing-task completion by servers and dishwashers at a restaurant. Based on the functional assessment results, an intervention consisting of task clarification, posted graphic feedback, and verbal feedback was implemented and evaluated with a multiple baseline design across two groups of employees. Results showed an increase of 15% and 38% in task completion for the two groups. PMID:15898481

Acquisition of graphic communication by a young girl without comprehension of spoken language.

PubMed

von Tetzchner, S; Øvreeide, K D; Jørgensen, K K; Ormhaug, B M; Oxholm, B; Warme, R

To describe a graphic-mode communication intervention involving a girl with intellectual impairment and autism who did not develop comprehension of spoken language. The aim was to teach graphic-mode vocabulary that reflected her interests, preferences, and the activities and routines of her daily life, by providing sufficient cues to the meanings of the graphic representations so that she would not need to comprehend spoken instructions. An individual case study design was selected, including the use of written records, participant observation, and registration of the girl's graphic vocabulary and use of graphic signs and other communicative expressions. While the girl's comprehension (and hence use) of spoken language remained lacking over a 3-year period, she acquired an active use of over 80 photographs and pictograms. The girl was able to cope better with the cognitive and attentional requirements of graphic communication than those of spoken language and manual signs, which had been focused in earlier interventions. Her achievements demonstrate that it is possible for communication-impaired children to learn to use an augmentative and alternative communication system without speech comprehension, provided the intervention utilizes functional strategies and non-language cues to the meaning of the graphic representations that are taught.

Assessment of a User Guide for One Semi-Automated Forces (OneSAF) Version 2.0

DTIC Science & Technology

2009-09-01

OneSAF uses a two-dimensional feature named a Plan View Display ( PVD ) as the primary graphical interface. The PVD replicates a map with a series...primary interface, the PVD is how the user watches the scenario unfold and requires the most interaction with the user. As seen in Table 3, all...participant indicated never using these seven map-related functions. Graphic control measures. Graphic control measures are applied to the PVD map to

Architectures for single-chip image computing

NASA Astrophysics Data System (ADS)

Gove, Robert J.

1992-04-01

This paper will focus on the architectures of VLSI programmable processing components for image computing applications. TI, the maker of industry-leading RISC, DSP, and graphics components, has developed an architecture for a new-generation of image processors capable of implementing a plurality of image, graphics, video, and audio computing functions. We will show that the use of a single-chip heterogeneous MIMD parallel architecture best suits this class of processors--those which will dominate the desktop multimedia, document imaging, computer graphics, and visualization systems of this decade.

Proceedings of the Conference on Behavior Representation in Modeling and Simulation (19th), held in Charleston, South Carolina, 21 - 24 March 2010

DTIC Science & Technology

2010-03-01

user performance .” “Wonderful. I can clearly see how, as a practitioner in industry , I can apply this to the numerous projects I work on.” Proceedings...CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ...effects on performance ), libraries of basic human operator procedures (how-to knowledge) and geometries for building scenarios graphically (that

Cumulative and Synergistic Effects of Physical, Biological, and Acoustic Signals on Marine Mammal Habitat Use Physical Oceanography Component: Soundscapes Under Sea Ice: Can We Listen for Open Water?

DTIC Science & Technology

2013-09-30

Physical, Biological, and Acoustic Signals on Marine Mammal Habitat Use Physical Oceanography Component: Soundscapes Under Sea Ice: Can we listen for... Soundscapes Under Sea Ice: Can we listen for open water? 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...the source. These different sounds can be described as “ soundscapes ”, and graphically represented by comparing two or more features of the sound

48 CFR 502.101 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Acquisition Service (FAS), a director of a Central Office or Regional office Division responsible for performing contracting or contract administration functions. (b) In FAS Central Office— (1) The Assistant... functions. (c) In FAS Regions, the Assistant Regional Commissioner or designee. Contracting officer's...

48 CFR 502.101 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Acquisition Service (FAS), a director of a Central Office or Regional office Division responsible for performing contracting or contract administration functions. (b) In FAS Central Office— (1) The Assistant... functions. (c) In FAS Regions, the Assistant Regional Commissioner or designee. Contracting officer's...

48 CFR 502.101 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Acquisition Service (FAS), a director of a Central Office or Regional office Division responsible for performing contracting or contract administration functions. (b) In FAS Central Office— (1) The Assistant... functions. (c) In FAS Regions, the Assistant Regional Commissioner or designee. Contracting officer's...

48 CFR 502.101 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Acquisition Service (FAS), a director of a Central Office or Regional office Division responsible for performing contracting or contract administration functions. (b) In FAS Central Office— (1) The Assistant... functions. (c) In FAS Regions, the Assistant Regional Commissioner or designee. Contracting officer's...

48 CFR 502.101 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Acquisition Service (FAS), a director of a Central Office or Regional office Division responsible for performing contracting or contract administration functions. (b) In FAS Central Office— (1) The Assistant... functions. (c) In FAS Regions, the Assistant Regional Commissioner or designee. Contracting officer's...

Communication: A reduced scaling J-engine based reformulation of SOS-MP2 using graphics processing units.

PubMed

Maurer, S A; Kussmann, J; Ochsenfeld, C

2014-08-07

We present a low-prefactor, cubically scaling scaled-opposite-spin second-order Møller-Plesset perturbation theory (SOS-MP2) method which is highly suitable for massively parallel architectures like graphics processing units (GPU). The scaling is reduced from O(N⁵) to O(N³) by a reformulation of the MP2-expression in the atomic orbital basis via Laplace transformation and the resolution-of-the-identity (RI) approximation of the integrals in combination with efficient sparse algebra for the 3-center integral transformation. In contrast to previous works that employ GPUs for post Hartree-Fock calculations, we do not simply employ GPU-based linear algebra libraries to accelerate the conventional algorithm. Instead, our reformulation allows to replace the rate-determining contraction step with a modified J-engine algorithm, that has been proven to be highly efficient on GPUs. Thus, our SOS-MP2 scheme enables us to treat large molecular systems in an accurate and efficient manner on a single GPU-server.

Derivative, maxima and minima in a graphical context

NASA Astrophysics Data System (ADS)

Rivera-Figueroa, Antonio; Ponce-Campuzano, Juan Carlos

2013-03-01

A deeper learning of the properties and applications of the derivative for the study of functions may be achieved when teachers present lessons within a highly graphic context, linking the geometric illustrations to formal proofs. Each concept is better understood and more easily retained when it is presented and explained visually using graphs. In this article, we explore the conditions of necessity or sufficiency of the criteria for determining the maxima and minima of a function. The implications for the teaching of derivatives and functions in undergraduate courses are discussed in light of our analysis of textbooks.

Arrows: A Special Case of Graphic Communication.

ERIC Educational Resources Information Center

Hardin, Pris

The purpose of this paper is to examine arrow design in relation to the type of pointing, connecting, or processing involved. Three possible approaches to the investigation of arrows as graphic communication include research: by arrow function, relating message structure to arrow design, and linking user expectations to arrow design. The following…

The Impact of Conflicting Goals on Mathematical Teaching Decisions

ERIC Educational Resources Information Center

Thomas, Mike; Yoon, Caroline

2014-01-01

This paper describes part of an international project considering graphical construction of antiderivative functions in the secondary mathematics classroom. We use Schoenfeld's resources, orientations, and goals (ROGs) framework to analyse the decisions made by a teacher, Adam, during a lesson on graphical antiderivatives. We present details…

48 CFR 207.503 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... are exempt from private sector performance, as addressed in DoD Instruction 1100.22. (S-70) Contracts... a contract for performance of the acquisition functions closely associated with inherently... functions; (B) Will oversee contractor performance of the contract; and (C) Will perform all inherently...

48 CFR 207.503 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... are exempt from private sector performance, as addressed in DoD Instruction 1100.22. (S-70) Contracts... a contract for performance of the acquisition functions closely associated with inherently... functions; (B) Will oversee contractor performance of the contract; and (C) Will perform all inherently...

Use of force feedback to enhance graphical user interfaces

NASA Astrophysics Data System (ADS)

Rosenberg, Louis B.; Brave, Scott

1996-04-01

This project focuses on the use of force feedback sensations to enhance user interaction with standard graphical user interface paradigms. While typical joystick and mouse devices are input-only, force feedback controllers allow physical sensations to be reflected to a user. Tasks that require users to position a cursor on a given target can be enhanced by applying physical forces to the user that aid in targeting. For example, an attractive force field implemented at the location of a graphical icon can greatly facilitate target acquisition and selection of the icon. It has been shown that force feedback can enhance a users ability to perform basic functions within graphical user interfaces.

Development of a graphical user interface for the global land information system (GLIS)

USGS Publications Warehouse

Alstad, Susan R.; Jackson, David A.

1993-01-01

The process of developing a Motif Graphical User Interface for the Global Land Information System (GLIS) involved incorporating user requirements, in-house visual and functional design requirements, and Open Software Foundation (OSF) Motif style guide standards. Motif user interface windows have been developed using the software to support Motif window functions war written using the C programming language. The GLIS architecture was modified to support multiple servers and remote handlers running the X Window System by forming a network of servers and handlers connected by TCP/IP communications. In April 1993, prior to release the GLIS graphical user interface and system architecture modifications were test by developers and users located at the EROS Data Center and 11 beta test sites across the country.

48 CFR 42.202 - Assignment of contract administration.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Assignment of contract administration. (a) Delegating functions. As provided in agency procedures... appropriate) of any functions withheld from or additional functions delegated to the CAO. (c) Delegating...

48 CFR 42.202 - Assignment of contract administration.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Assignment of contract administration. (a) Delegating functions. As provided in agency procedures... appropriate) of any functions withheld from or additional functions delegated to the CAO. (c) Delegating...

Development of Intelligent Suits for Disuse Atrophy of Musculoskeletal System Using Hybrid Exercise Method

NASA Astrophysics Data System (ADS)

Shiba, Naoto; Yoshimitsu, Kazuhiro; Matsugaki, Tohru; Narita, Arata; Maeda, Takashi; Inada, Tomohisa; Tagawa, Yoshihiko; Numada, Kiyoshi; Nishi, Tetsuya

We developed ‘Hybrid exercise’ method that was designed to maintain the musculoskeletal system by using electrically stimulated antagonist muscles to resist volitional contraction of agonist muscles. This approach also produces a minimum of inertial reaction forces and has the advantage that it may minimize the need for external stabilization that is currently necessary during exercise in a weightlessness environment. The purpose of this study was to develop the intelligent suits with virtual reality (VR) system that had function of preventing disuse atrophy of musculoskeletal system using hybrid exercise system. Installing of the hybrid exercise system to the subject became easy by the intelligent suits. VR system realized the sense of sight by computer graphics animation synchronized with subjects' motion, and sense of force induced by electrical stimulation. By using VR system, the management of the exercise accomplishment degree was enabled easily because the device could record the exercise history. Intelligent suits with VR hybrid exercise system might become one of the useful countermeasures for the disuse musculoskeletal system in the space.

The Graphical Representation of the Digital Astronaut Physiology Backbone

NASA Technical Reports Server (NTRS)

Briers, Demarcus

2010-01-01

This report summarizes my internship project with the NASA Digital Astronaut Project to analyze the Digital Astronaut (DA) physiology backbone model. The Digital Astronaut Project (DAP) applies integrated physiology models to support space biomedical operations, and to assist NASA researchers in closing knowledge gaps related to human physiologic responses to space flight. The DA physiology backbone is a set of integrated physiological equations and functions that model the interacting systems of the human body. The current release of the model is HumMod (Human Model) version 1.5 and was developed over forty years at the University of Mississippi Medical Center (UMMC). The physiology equations and functions are scripted in an XML schema specifically designed for physiology modeling by Dr. Thomas G. Coleman at UMMC. Currently it is difficult to examine the physiology backbone without being knowledgeable of the XML schema. While investigating and documenting the tags and algorithms used in the XML schema, I proposed a standard methodology for a graphical representation. This standard methodology may be used to transcribe graphical representations from the DA physiology backbone. In turn, the graphical representations can allow examination of the physiological functions and equations without the need to be familiar with the computer programming languages or markup languages used by DA modeling software.

Real-time colouring and filtering with graphics shaders

NASA Astrophysics Data System (ADS)

Vohl, D.; Fluke, C. J.; Barnes, D. G.; Hassan, A. H.

2017-11-01

Despite the popularity of the Graphics Processing Unit (GPU) for general purpose computing, one should not forget about the practicality of the GPU for fast scientific visualization. As astronomers have increasing access to three-dimensional (3D) data from instruments and facilities like integral field units and radio interferometers, visualization techniques such as volume rendering offer means to quickly explore spectral cubes as a whole. As most 3D visualization techniques have been developed in fields of research like medical imaging and fluid dynamics, many transfer functions are not optimal for astronomical data. We demonstrate how transfer functions and graphics shaders can be exploited to provide new astronomy-specific explorative colouring methods. We present 12 shaders, including four novel transfer functions specifically designed to produce intuitive and informative 3D visualizations of spectral cube data. We compare their utility to classic colour mapping. The remaining shaders highlight how common computation like filtering, smoothing and line ratio algorithms can be integrated as part of the graphics pipeline. We discuss how this can be achieved by utilizing the parallelism of modern GPUs along with a shading language, letting astronomers apply these new techniques at interactive frame rates. All shaders investigated in this work are included in the open source software shwirl (Vohl 2017).

Integration of Modelling and Graphics to Create an Infrared Signal Processing Test Bed

NASA Astrophysics Data System (ADS)

Sethi, H. R.; Ralph, John E.

1989-03-01

The work reported in this paper was carried out as part of a contract with MoD (PE) UK. It considers the problems associated with realistic modelling of a passive infrared system in an operational environment. Ideally all aspects of the system and environment should be integrated into a complete end-to-end simulation but in the past limited computing power has prevented this. Recent developments in workstation technology and the increasing availability of parallel processing techniques makes the end-to-end simulation possible. However the complexity and speed of such simulations means difficulties for the operator in controlling the software and understanding the results. These difficulties can be greatly reduced by providing an extremely user friendly interface and a very flexible, high power, high resolution colour graphics capability. Most system modelling is based on separate software simulation of the individual components of the system itself and its environment. These component models may have their own characteristic inbuilt assumptions and approximations, may be written in the language favoured by the originator and may have a wide variety of input and output conventions and requirements. The models and their limitations need to be matched to the range of conditions appropriate to the operational scenerio. A comprehensive set of data bases needs to be generated by the component models and these data bases must be made readily available to the investigator. Performance measures need to be defined and displayed in some convenient graphics form. Some options are presented for combining available hardware and software to create an environment within which the models can be integrated, and which provide the required man-machine interface, graphics and computing power. The impact of massively parallel processing and artificial intelligence will be discussed. Parallel processing will make real time end-to-end simulation possible and will greatly improve the graphical visualisation of the model output data. Artificial intelligence should help to enhance the man-machine interface.

Development of Xi'an-CI package – applying the hole–particle symmetry in multi-reference electronic correlation calculations

NASA Astrophysics Data System (ADS)

Suo, Bingbing; Lei, Yibo; Han, Huixian; Wang, Yubin

2018-04-01

This mini-review introduces our works on the Xi'an-CI (configuration interaction) package using graphical unitary group approach (GUGA). Taking advantage of the hole-particle symmetry in GUGA, the Galfand states used to span the CI space are classified into CI subspaces according to the number of holes and particles, and the coupling coefficients used to calculate Hamiltonian matrix elements could be factorised into the segment factors in the hole, active and external spaces. An efficient multi-reference CI with single and double excitations (MRCISD) algorithm is thus developed that reduces the storage requirement and increases the number of correlated electrons significantly. The hole-particle symmetry also gives rise to a doubly contracted MRCISD approach. Moreover, the internally contracted Gelfand states are defined within the CI subspace arising from the hole-particle symmetry, which makes the implementation of internally contracted MRCISD in the framework of GUGA possible. In addition to MRCISD, the development of multi-reference second-order perturbation theory (MRPT2) also benefits from the hole-particle symmetry. A configuration-based MRPT2 algorithm is proposed and extended to the multi-state n-electron valence-state second-order perturbation theory.

48 CFR 17.603 - Limitations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 17.603 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.603 Limitations. (a) Management and operating contracts shall not be authorized for— (1) Functions involving the...

48 CFR 17.603 - Limitations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 17.603 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.603 Limitations. (a) Management and operating contracts shall not be authorized for— (1) Functions involving the...

41 CFR 105-53.112 - General statement of functions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... contracting; real and personal property management; transportation, public transportation, public utilities... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General statement of functions. 105-53.112 Section 105-53.112 Public Contracts and Property Management Federal Property...

48 CFR 942.270-1 - Contracting Officer's Representatives.

Code of Federal Regulations, 2010 CFR

2010-10-01

... performing certain technical functions in administering a contract. These functions include, but are not limited to, technical monitoring, inspection, approval of shop drawings, testing, and approval of samples. The COR acts solely as a technical representative of the contracting officer and is not authorized to...

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security Procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

48 CFR 1352.237-72 - Security processing requirements-national security contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... National Security Contracts require contractor employees to gain access to national security information in.... (c) Security Procedures. Position sensitivity/risk assessments must be conducted on all functions... same manner as assessment of those functions performed by government employees. The Contracting Officer...

Automated path planning of the Payload Inspection and Processing System

NASA Technical Reports Server (NTRS)

Byers, Robert M.

1994-01-01

The Payload Changeout Room Inspection and Processing System (PIPS) is a highly redundant manipulator intended for performing tasks in the crowded and sensitive environment of the Space Shuttle Orbiter payload bay. Its dexterity will be exploited to maneuver the end effector in a workspace populated with obstacles. A method is described by which the end effector of a highly redundant manipulator is directed toward a target via a Lyapunov stability function. A cost function is constructed which represents the distance from the manipulator links to obstacles. Obstacles are avoided by causing the vector of joint parameters to move orthogonally to the gradient of the workspace cost function. A C language program implements the algorithm to generate a joint history. The resulting motion is graphically displayed using the Interactive Graphical Robot Instruction Program (IGRIP) produced by Deneb Robotics. The graphical simulation has the potential to be a useful tool in path planning for the PIPS in the Shuttle Payload Bay environment.

Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation.

PubMed

Oner, Taliha; Ozdemir, Rahmi; Doksöz, Onder; Genc, Dildar B; Guven, Baris; Demirpence, Savas; Yilmazer, Murat M; Yozgat, Yilmaz; Mese, Timur; Tavli, Vedide

2018-07-01

Premature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans.AimWe evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial. A total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study. All patients underwent electrocardiography, left ventricular M-mode echocardiography, and myocardial performance index testing. Patients with premature ventricular contraction were given omega-3 fatty acids at a dose of 1 g/day for 3 months, and control echocardiography and 24-hour Holter electrocardiography were performed. Neither placebo nor omega-3 fatty acids were given to the control group. Compared with the values of the control group, the patients with premature ventricular contraction had significantly lower fractional shortening. The myocardial performance index decreased markedly in the patient groups. The mean heart rate and mean premature ventricular contraction percentage of Group 2 significantly decreased in comparison with their baseline values after the omega-3 supplementation. In conclusion, premature ventricular contractions can lead to systolic cardiac dysfunction in children. Omega-3 supplementation may improve cardiac function in children with premature ventricular contractions. This is the first study conducted in children to investigate the possible role of omega-3 fatty acid supplementation on treatment of premature ventricular contractions.

Derivative, Maxima and Minima in a Graphical Context

ERIC Educational Resources Information Center

Rivera-Figueroa, Antonio; Ponce-Campuzano, Juan Carlos

2013-01-01

A deeper learning of the properties and applications of the derivative for the study of functions may be achieved when teachers present lessons within a highly graphic context, linking the geometric illustrations to formal proofs. Each concept is better understood and more easily retained when it is presented and explained visually using graphs.…

Computer Graphics in Research: Some State -of-the-Art Systems

ERIC Educational Resources Information Center

Reddy, R.; And Others

1975-01-01

A description is given of the structure and functional characteristics of three types of interactive computer graphic systems, developed by the Department of Computer Science at Carnegie-Mellon; a high-speed programmable display capable of displaying 50,000 short vectors, flicker free; a shaded-color video display for the display of gray-scale…

The Effects of Graphic Similarity on Japanese Recognition of Simplified Chinese Characters

ERIC Educational Resources Information Center

Teng, Xiaochun; Yamada, Jun

2017-01-01

The pedagogical and theoretical questions addressed in this study relate to the extent to which native Japanese readers with little or no knowledge of Chinese characters recognize Chinese characters that are viewed as abbreviations of the kanji they already know. Three graphic similarity functions (i.e., an orthographically acceptable similarity,…

Graphic Communications--Preparatory Area. Book I--Typography and Modern Typesetting. Teacher's Manual.

ERIC Educational Resources Information Center

Hertz, Andrew

Intended for use with a companion student manual, this teacher's guide lists procedures and teaching tips for each unit of a secondary or postsecondary course of study in typography and modern typesetting. Course objectives are listed for developing student skills in the following preparatory functions of the graphic communications industry: copy…

Training a Mentally Retarded Woman to Work Competitively: Effect of Graphic Feedback and a Changing Criterion Design.

ERIC Educational Resources Information Center

Davis, Paula; And Others

1983-01-01

An on-the-job coach provided graphic feedback on the food service performance of a moderately retarded young woman. Her performance improved to a production range acceptable for competive employment. Feedback from co-workers revealed, however, that she was still not functioning adequately. (CL)

Sibling Curves and Complex Roots 1: Looking Back

ERIC Educational Resources Information Center

Harding, Ansie; Engelbrecht, Johann

2007-01-01

This paper, the first of a two-part article, follows the trail in history of the development of a graphical representation of the complex roots of a function. Root calculation and root representation are traced through millennia, including the development of the notion of complex numbers and subsequent graphical representation thereof. The…

Graphic Communications--Preparatory Area. Book I--Typography and Modern Typesetting. Student Manual.

ERIC Educational Resources Information Center

Hertz, Andrew

Designed to develop in the student skills in all of the preparatory functions of the graphic communications industry, this student guide covers copy preparation, art preparation, typography, camera, stripping, production management, and forms design, preparation, and analysis. In addition to the skills areas, material is included on the history of…

Analog-to-digital clinical data collection on networked workstations with graphic user interface.

PubMed

Lunt, D

1991-02-01

An innovative respiratory examination system has been developed that combines physiological response measurement, real-time graphic displays, user-driven operating sequences, and networked file archiving and review into a scientific research and clinical diagnosis tool. This newly constructed computer network is being used to enhance the research center's ability to perform patient pulmonary function examinations. Respiratory data are simultaneously acquired and graphically presented during patient breathing maneuvers and rapidly transformed into graphic and numeric reports, suitable for statistical analysis or database access. The environment consists of the hardware (Macintosh computer, MacADIOS converters, analog amplifiers), the software (HyperCard v2.0, HyperTalk, XCMDs), and the network (AppleTalk, fileservers, printers) as building blocks for data acquisition, analysis, editing, and storage. System operation modules include: Calibration, Examination, Reports, On-line Help Library, Graphic/Data Editing, and Network Storage.

Data display and analysis with μView

NASA Astrophysics Data System (ADS)

Tucakov, Ivan; Cosman, Jacob; Brewer, Jess H.

2006-03-01

The μView utility is a new Java applet version of the old db program, extended to include direct access to MUD data files, from which it can construct a variety of spectrum types, including complex and RRF-transformed spectra. By using graphics features built into all modern Web browsers, it provides full graphical display capabilities consistently across all platforms. It has the full command-line functionality of db as well as a more intuitive graphical user interface and extensive documentation, and can read and write db, csv and XML format files.

Contracted or uncontracted polarization functions? Comment on Dunning's correlation-consistent basis sets

NASA Astrophysics Data System (ADS)

Hashimoto, Tomohiro; Hirao, Kimihiko; Tatewaki, Hiroshi

1997-07-01

For the sake of computational economy, the polarization functions given by Dunning are contracted by multiconfigurational SCF calculations for H, B, C, N, O, F and Ne atoms. For the first-row atoms, B through Ne, the generated contracted polarization functions are ( 2 d/1 d) and ( 3 d/2 d) and for H they are ( 2 p/1 p), ( 3 p/1 p), and ( 3 p/2 p) where the numbers before and after the slash are the numbers of uncontracted and contracted polarization functions. Numerical examples on some diatomic molecules and benzene illustrate a large improvement in going from ( 1 d/1 dto ( 2 d/1 d) for various molecular properties.

VQone MATLAB toolbox: A graphical experiment builder for image and video quality evaluations: VQone MATLAB toolbox.

PubMed

Nuutinen, Mikko; Virtanen, Toni; Rummukainen, Olli; Häkkinen, Jukka

2016-03-01

This article presents VQone, a graphical experiment builder, written as a MATLAB toolbox, developed for image and video quality ratings. VQone contains the main elements needed for the subjective image and video quality rating process. This includes building and conducting experiments and data analysis. All functions can be controlled through graphical user interfaces. The experiment builder includes many standardized image and video quality rating methods. Moreover, it enables the creation of new methods or modified versions from standard methods. VQone is distributed free of charge under the terms of the GNU general public license and allows code modifications to be made so that the program's functions can be adjusted according to a user's requirements. VQone is available for download from the project page (http://www.helsinki.fi/psychology/groups/visualcognition/).

Application of web-GIS approach for climate change study

NASA Astrophysics Data System (ADS)

Okladnikov, Igor; Gordov, Evgeny; Titov, Alexander; Bogomolov, Vasily; Martynova, Yuliya; Shulgina, Tamara

2013-04-01

Georeferenced datasets are currently actively used in numerous applications including modeling, interpretation and forecast of climatic and ecosystem changes for various spatial and temporal scales. Due to inherent heterogeneity of environmental datasets as well as their huge size which might constitute up to tens terabytes for a single dataset at present studies in the area of climate and environmental change require a special software support. A dedicated web-GIS information-computational system for analysis of georeferenced climatological and meteorological data has been created. It is based on OGC standards and involves many modern solutions such as object-oriented programming model, modular composition, and JavaScript libraries based on GeoExt library, ExtJS Framework and OpenLayers software. The main advantage of the system lies in a possibility to perform mathematical and statistical data analysis, graphical visualization of results with GIS-functionality, and to prepare binary output files with just only a modern graphical web-browser installed on a common desktop computer connected to Internet. Several geophysical datasets represented by two editions of NCEP/NCAR Reanalysis, JMA/CRIEPI JRA-25 Reanalysis, ECMWF ERA-40 Reanalysis, ECMWF ERA Interim Reanalysis, MRI/JMA APHRODITE's Water Resources Project Reanalysis, DWD Global Precipitation Climatology Centre's data, GMAO Modern Era-Retrospective analysis for Research and Applications, meteorological observational data for the territory of the former USSR for the 20th century, results of modeling by global and regional climatological models, and others are available for processing by the system. And this list is extending. Also a functionality to run WRF and "Planet simulator" models was implemented in the system. Due to many preset parameters and limited time and spatial ranges set in the system these models have low computational power requirements and could be used in educational workflow for better understanding of basic climatological and meteorological processes. The Web-GIS information-computational system for geophysical data analysis provides specialists involved into multidisciplinary research projects with reliable and practical instruments for complex analysis of climate and ecosystems changes on global and regional scales. Using it even unskilled user without specific knowledge can perform computational processing and visualization of large meteorological, climatological and satellite monitoring datasets through unified web-interface in a common graphical web-browser. This work is partially supported by the Ministry of education and science of the Russian Federation (contract #8345), SB RAS project VIII.80.2.1, RFBR grant #11-05-01190a, and integrated project SB RAS #131.

Uterine Contraction Modeling and Simulation

NASA Technical Reports Server (NTRS)

Liu, Miao; Belfore, Lee A.; Shen, Yuzhong; Scerbo, Mark W.

2010-01-01

Building a training system for medical personnel to properly interpret fetal heart rate tracing requires developing accurate models that can relate various signal patterns to certain pathologies. In addition to modeling the fetal heart rate signal itself, the change of uterine pressure that bears strong relation to fetal heart rate and provides indications of maternal and fetal status should also be considered. In this work, we have developed a group of parametric models to simulate uterine contractions during labor and delivery. Through analysis of real patient records, we propose to model uterine contraction signals by three major components: regular contractions, impulsive noise caused by fetal movements, and low amplitude noise invoked by maternal breathing and measuring apparatus. The regular contractions are modeled by an asymmetric generalized Gaussian function and least squares estimation is used to compute the parameter values of the asymmetric generalized Gaussian function based on uterine contractions of real patients. Regular contractions are detected based on thresholding and derivative analysis of uterine contractions. Impulsive noise caused by fetal movements and low amplitude noise by maternal breathing and measuring apparatus are modeled by rational polynomial functions and Perlin noise, respectively. Experiment results show the synthesized uterine contractions can mimic the real uterine contractions realistically, demonstrating the effectiveness of the proposed algorithm.

Analysis of graphic representation ability in oscillation phenomena

NASA Astrophysics Data System (ADS)

Dewi, A. R. C.; Putra, N. M. D.; Susilo

2018-03-01

This study aims to investigates how the ability of students to representation graphs of linear function and harmonic function in understanding of oscillation phenomena. Method of this research used mix methods with concurrent embedded design. The subjects were 35 students of class X MIA 3 SMA 1 Bae Kudus. Data collection through giving essays and interviews that lead to the ability to read and draw graphs in material of Hooke's law and oscillation characteristics. The results of study showed that most of the students had difficulty in drawing graph of linear function and harmonic function of deviation with time. Students’ difficulties in drawing the graph of linear function is the difficulty of analyzing the variable data needed in graph making, confusing the placement of variable data on the coordinate axis, the difficulty of determining the scale interval on each coordinate, and the variation of how to connect the dots forming the graph. Students’ difficulties in representing the graph of harmonic function is to determine the time interval of sine harmonic function, the difficulty to determine the initial deviation point of the drawing, the difficulty of finding the deviation equation of the case of oscillation characteristics and the confusion to different among the maximum deviation (amplitude) with the length of the spring caused the load.Complexity of the characteristic attributes of the oscillation phenomena graphs, students tend to show less well the ability of graphical representation of harmonic functions than the performance of the graphical representation of linear functions.

MioLab, a rat cardiac contractile force simulator: Applications to teaching cardiac cell physiology and biophysics.

PubMed

da Silva, Robson Rodrigues; Bissaco, Marcia Aparecida Silva; Goroso, Daniel Gustavo

2015-12-01

Understanding the basic concepts of physiology and biophysics of cardiac cells can be improved by virtual experiments that illustrate the complex excitation-contraction coupling process in cardiac cells. The aim of this study is to propose a rat cardiac myocyte simulator, with which calcium dynamics in excitation-contraction coupling of an isolated cell can be observed. This model has been used in the course "Mathematical Modeling and Simulation of Biological Systems". In this paper we present the didactic utility of the simulator MioLab(®). The simulator enables virtual experiments that can help studying inhibitors and activators in the sarcoplasmic reticulum sodium-calcium exchanger, thus corroborating a better understanding of the effects of medications, which are used to treat arrhythmias, on these compartments. The graphical interfaces were developed not only to facilitate the use of the simulator, but also to promote a constructive learning on the subject, since there are animations and videos for each stage of the simulation. The effectiveness of the simulator was tested by a group of graduate students. Some examples of simulations were presented in order to describe the overall structure of the simulator. Part of these virtual experiments became an activity for Biomedical Engineering graduate students, who evaluated the simulator based on its didactic quality. As a result, students answered a questionnaire on the usability and functionality of the simulator as a teaching tool. All students performed the proposed activities and classified the simulator as an optimal or good learning tool. In their written questions, students indicated as negative characteristics some problems with visualizing graphs; as positive characteristics, they indicated the simulator's didactic function, especially tutorials and videos on the topic of this study. The results show that the simulator complements the study of the physiology and biophysics of the cardiac cell. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The Effectiveness of Electronic Text and Pictorial Graphic Organizers to Improve Comprehension Related to Functional Skills

ERIC Educational Resources Information Center

Douglas, Karen H.; Ayres, Kevin M.; Langone, John; Bramlett, Virginia Bell

2011-01-01

This study evaluated the effects of a computer-based instructional program to assist three students with mild to moderate intellectual disabilities in using pictorial graphic organizers as aids for increasing comprehension of electronic text-based recipes. Student comprehension of recipes was measured by their ability to verbally retell recipe…

A Graphics System for Pole-Zero Map Analysis.

ERIC Educational Resources Information Center

Beyer, William Fred, III

Computer scientists have developed an interactive, graphical display system for pole-zero map analysis. They designed it for use as an educational tool in teaching introductory courses in automatic control systems. The facilities allow the user to specify a control system and an input function in the form of a pole-zero map and then examine the…

Stable stress‐drop measurements and their variability: Implications for ground‐motion prediction

USGS Publications Warehouse

Hanks, Thomas C.; Baltay, Annemarie S.; Beroza, Gregory C.

2013-01-01

We estimate the arms‐stress drop, Graphic, (Hanks, 1979) using acceleration time records of 59 earthquakes from two earthquake sequences in eastern Honshu, Japan. These acceleration‐based static stress drops compare well to stress drops calculated for the same events by Baltay et al. (2011) using an empirical Green’s function (eGf) approach. This agreement supports the assumption that earthquake acceleration time histories in the bandwidth between the corner frequency and a maximum observed frequency can be considered white, Gaussian, noise. Although the Graphic is computationally simpler than the eGf‐based Graphic‐stress drop, and is used as the “stress parameter” to describe the earthquake source in ground‐motion prediction equations, we find that it only compares well to the Graphic at source‐station distances of ∼20  km or less because there is no consideration of whole‐path anelastic attenuation or scattering. In these circumstances, the correlation between the Graphic and Graphic is strong. Events with high and low stress drops obtained through the eGf method have similarly high and low Graphic. We find that the inter‐event standard deviation of stress drop, for the population of earthquakes considered, is similar for both methods, 0.40 for the Graphic method and 0.42 for the Graphic, in log10 units, provided we apply the ∼20  km distance restriction to Graphic. This indicates that the observed variability is inherent to the source, rather than attributable to uncertainties in stress‐drop estimates

Advanced helmet vision system (AHVS) integrated night vision helmet mounted display (HMD)

NASA Astrophysics Data System (ADS)

Ashcraft, Todd W.; Atac, Robert

2012-06-01

Gentex Corporation, under contract to Naval Air Systems Command (AIR 4.0T), designed the Advanced Helmet Vision System to provide aircrew with 24-hour, visor-projected binocular night vision and HMD capability. AHVS integrates numerous key technologies, including high brightness Light Emitting Diode (LED)-based digital light engines, advanced lightweight optical materials and manufacturing processes, and innovations in graphics processing software. This paper reviews the current status of miniaturization and integration with the latest two-part Gentex modular helmet, highlights the lessons learned from previous AHVS phases, and discusses plans for qualification and flight testing.

Geologic map of the eastern part of the Challis National Forest and vicinity, Idaho

USGS Publications Warehouse

Wilson, A.B.; Skipp, B.A.

1994-01-01

The paper version of the Geologic Map of the eastern part of the Challis National Forest and vicinity, Idaho was compiled by Anna Wilson and Betty Skipp in 1994. The geology was compiled on a 1:250,000 scale topographic base map. TechniGraphic System, Inc. of Fort Collins Colorado digitized this map under contract for N.Shock. G.Green edited and prepared the digital version for publication as a GIS database. The digital geologic map database can be queried in many ways to produce a variety of geologic maps.

Comparative studies on troponin, a Ca²⁺-dependent regulator of muscle contraction, in striated and smooth muscles of protochordates.

PubMed

Obinata, Takashi; Sato, Naruki

2012-01-01

Troponin is well known as a Ca(2+)-dependent regulator of striated muscle contraction and it has been generally accepted that troponin functions as an inhibitor of muscle contraction or actin-myosin interaction at low Ca(2+) concentrations, and Ca(2+) at higher concentrations removes the inhibitory action of troponin. Recently, however, troponin became detectable in non-striated muscles of several invertebrates and in addition, unique troponin that functions as a Ca(2+)-dependent activator of muscle contraction has been detected in protochordate animals, although troponin in vertebrate striated muscle is known as an inhibitor of the contraction in the absence of a Ca(2+). Further studies on troponin in invertebrate muscle, especially in non-striated muscle, would provide new insight into the evolution of regulatory systems for muscle contraction and diverse function of troponin and related proteins. The methodology used for preparation and characterization of functional properties of protochordate striated and smooth muscles will be helpful for further studies of troponin in other invertebrate animals. Copyright © 2011. Published by Elsevier Inc.

Interfacing 1990 US Census TIGER map files with New S graphics software. [Topologically Integrated Geographic Encoding and Referencing (TIGER)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rizzardi, M.; Mohr, M.S.; Merrill, D.W.

1992-07-01

In 1990, the United States Bureau of the Census released detailed geographic base files known as TIGER/Line (Topologically Integrated Geographic Encoding and Referencing) which contain detail on the physical features and census tract boundaries of every county in the United States. The TIGER database is attractive for two reasons. First, it is publicly available through the Bureau of the Census on tape or cd-rom for a minimal fee. Second, it contains 24 billion characters of data which describe geographic features of interest to the Census Bureau such as coastlines, hydrography, transportation networks, political boundaries, etc. Unfortunately, the large TIGER databasemore » only provides raw alphanumeric data; no utility software, graphical or otherwise, is included. On the other hand New S, a popular statistical software package by AT T, has easily operated functions that permit advanced graphics in conjunction with data analysis. New S has the ability to plot contours, lines, segments, and points. However, of special interest is the New S function map and its options. Using the map function, which requires polygons as input, census tracts can be quickly selected, plotted, shaded, etc. New S graphics combined with the TIGER database has obvious potential. This paper reports on our efforts to use the TIGER map files with New S, especially to construct census tract maps of counties. While census tract boundaries are inherently polygonal, they are not organized as such in the TIGER database. This conversion of the TIGER line'' format into New S polygon/polyline'' format is one facet of the work reported here. Also we discuss the selection and extraction of auxiliary geographic information from TIGER files for graphical display using New S.« less

Interfacing 1990 US Census TIGER map files with New S graphics software

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rizzardi, M.; Mohr, M.S.; Merrill, D.W.

1992-07-01

In 1990, the United States Bureau of the Census released detailed geographic base files known as TIGER/Line (Topologically Integrated Geographic Encoding and Referencing) which contain detail on the physical features and census tract boundaries of every county in the United States. The TIGER database is attractive for two reasons. First, it is publicly available through the Bureau of the Census on tape or cd-rom for a minimal fee. Second, it contains 24 billion characters of data which describe geographic features of interest to the Census Bureau such as coastlines, hydrography, transportation networks, political boundaries, etc. Unfortunately, the large TIGER databasemore » only provides raw alphanumeric data; no utility software, graphical or otherwise, is included. On the other hand New S, a popular statistical software package by AT&T, has easily operated functions that permit advanced graphics in conjunction with data analysis. New S has the ability to plot contours, lines, segments, and points. However, of special interest is the New S function map and its options. Using the map function, which requires polygons as input, census tracts can be quickly selected, plotted, shaded, etc. New S graphics combined with the TIGER database has obvious potential. This paper reports on our efforts to use the TIGER map files with New S, especially to construct census tract maps of counties. While census tract boundaries are inherently polygonal, they are not organized as such in the TIGER database. This conversion of the TIGER ``line`` format into New S ``polygon/polyline`` format is one facet of the work reported here. Also we discuss the selection and extraction of auxiliary geographic information from TIGER files for graphical display using New S.« less

Functional Effects of Hyperthyroidism on Cardiac Papillary Muscle in Rats.

PubMed

Vieira, Fabricio Furtado; Olivoto, Robson Ruiz; Silva, Priscyla Oliveira da; Francisco, Julio Cesar; Fogaça, Rosalvo Tadeu Hochmuller

2016-12-01

Hyperthyroidism is currently recognized to affect the cardiovascular system, leading to a series of molecular and functional changes. However, little is known about the functional influence of hyperthyroidism in the regulation of cytoplasmic calcium and on the sodium/calcium exchanger (NCX) in the cardiac muscle. To evaluate the functional changes in papillary muscles isolated from animals with induced hyperthyroidism. We divided 36 Wistar rats into a group of controls and another of animals with hyperthyroidism induced by intraperitoneal T3 injection. We measured in the animals' papillary muscles the maximum contraction force, speed of contraction (+df/dt) and relaxation (-df/dt), contraction and relaxation time, contraction force at different concentrations of extracellular sodium, post-rest potentiation (PRP), and contraction force induced by caffeine. In hyperthyroid animals, we observed decreased PRP at all rest times (p < 0.05), increased +df/dt and -df/dt (p < 0.001), low positive inotropic response to decreased concentration of extracellular sodium (p < 0.001), reduction of the maximum force in caffeine-induced contraction (p < 0.003), and decreased total contraction time (p < 0.001). The maximal contraction force did not differ significantly between groups (p = 0.973). We hypothesize that the changes observed are likely due to a decrease in calcium content in the sarcoplasmic reticulum, caused by calcium leakage, decreased expression of NCX, and increased expression of a-MHC and SERCA2.

Robust Gaussian Graphical Modeling via l1 Penalization

PubMed Central

Sun, Hokeun; Li, Hongzhe

2012-01-01

Summary Gaussian graphical models have been widely used as an effective method for studying the conditional independency structure among genes and for constructing genetic networks. However, gene expression data typically have heavier tails or more outlying observations than the standard Gaussian distribution. Such outliers in gene expression data can lead to wrong inference on the dependency structure among the genes. We propose a l1 penalized estimation procedure for the sparse Gaussian graphical models that is robustified against possible outliers. The likelihood function is weighted according to how the observation is deviated, where the deviation of the observation is measured based on its own likelihood. An efficient computational algorithm based on the coordinate gradient descent method is developed to obtain the minimizer of the negative penalized robustified-likelihood, where nonzero elements of the concentration matrix represents the graphical links among the genes. After the graphical structure is obtained, we re-estimate the positive definite concentration matrix using an iterative proportional fitting algorithm. Through simulations, we demonstrate that the proposed robust method performs much better than the graphical Lasso for the Gaussian graphical models in terms of both graph structure selection and estimation when outliers are present. We apply the robust estimation procedure to an analysis of yeast gene expression data and show that the resulting graph has better biological interpretation than that obtained from the graphical Lasso. PMID:23020775

41 CFR 105-53.150 - Organization and functions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Organization and functions. 105-53.150 Section 105-53.150 Public Contracts and Property Management Federal Property... FUNCTIONS Regional Offices § 105-53.150 Organization and functions. Regional offices have been established...

InteGO2: A web tool for measuring and visualizing gene semantic similarities using Gene Ontology

DOE PAGES

Peng, Jiajie; Li, Hongxiang; Liu, Yongzhuang; ...

2016-08-31

Here, the Gene Ontology (GO) has been used in high-throughput omics research as a major bioinformatics resource. The hierarchical structure of GO provides users a convenient platform for biological information abstraction and hypothesis testing. Computational methods have been developed to identify functionally similar genes. However, none of the existing measurements take into account all the rich information in GO. Similarly, using these existing methods, web-based applications have been constructed to compute gene functional similarities, and to provide pure text-based outputs. Without a graphical visualization interface, it is difficult for result interpretation. As a result, we present InteGO2, a web toolmore » that allows researchers to calculate the GO-based gene semantic similarities using seven widely used GO-based similarity measurements. Also, we provide an integrative measurement that synergistically integrates all the individual measurements to improve the overall performance. Using HTML5 and cytoscape.js, we provide a graphical interface in InteGO2 to visualize the resulting gene functional association networks. In conclusion, InteGO2 is an easy-to-use HTML5 based web tool. With it, researchers can measure gene or gene product functional similarity conveniently, and visualize the network of functional interactions in a graphical interface.« less

InteGO2: a web tool for measuring and visualizing gene semantic similarities using Gene Ontology.

PubMed

Peng, Jiajie; Li, Hongxiang; Liu, Yongzhuang; Juan, Liran; Jiang, Qinghua; Wang, Yadong; Chen, Jin

2016-08-31

The Gene Ontology (GO) has been used in high-throughput omics research as a major bioinformatics resource. The hierarchical structure of GO provides users a convenient platform for biological information abstraction and hypothesis testing. Computational methods have been developed to identify functionally similar genes. However, none of the existing measurements take into account all the rich information in GO. Similarly, using these existing methods, web-based applications have been constructed to compute gene functional similarities, and to provide pure text-based outputs. Without a graphical visualization interface, it is difficult for result interpretation. We present InteGO2, a web tool that allows researchers to calculate the GO-based gene semantic similarities using seven widely used GO-based similarity measurements. Also, we provide an integrative measurement that synergistically integrates all the individual measurements to improve the overall performance. Using HTML5 and cytoscape.js, we provide a graphical interface in InteGO2 to visualize the resulting gene functional association networks. InteGO2 is an easy-to-use HTML5 based web tool. With it, researchers can measure gene or gene product functional similarity conveniently, and visualize the network of functional interactions in a graphical interface. InteGO2 can be accessed via http://mlg.hit.edu.cn:8089/ .

InteGO2: A web tool for measuring and visualizing gene semantic similarities using Gene Ontology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peng, Jiajie; Li, Hongxiang; Liu, Yongzhuang

Here, the Gene Ontology (GO) has been used in high-throughput omics research as a major bioinformatics resource. The hierarchical structure of GO provides users a convenient platform for biological information abstraction and hypothesis testing. Computational methods have been developed to identify functionally similar genes. However, none of the existing measurements take into account all the rich information in GO. Similarly, using these existing methods, web-based applications have been constructed to compute gene functional similarities, and to provide pure text-based outputs. Without a graphical visualization interface, it is difficult for result interpretation. As a result, we present InteGO2, a web toolmore » that allows researchers to calculate the GO-based gene semantic similarities using seven widely used GO-based similarity measurements. Also, we provide an integrative measurement that synergistically integrates all the individual measurements to improve the overall performance. Using HTML5 and cytoscape.js, we provide a graphical interface in InteGO2 to visualize the resulting gene functional association networks. In conclusion, InteGO2 is an easy-to-use HTML5 based web tool. With it, researchers can measure gene or gene product functional similarity conveniently, and visualize the network of functional interactions in a graphical interface.« less

Graphical programming interface: A development environment for MRI methods.

PubMed

Zwart, Nicholas R; Pipe, James G

2015-11-01

To introduce a multiplatform, Python language-based, development environment called graphical programming interface for prototyping MRI techniques. The interface allows developers to interact with their scientific algorithm prototypes visually in an event-driven environment making tasks such as parameterization, algorithm testing, data manipulation, and visualization an integrated part of the work-flow. Algorithm developers extend the built-in functionality through simple code interfaces designed to facilitate rapid implementation. This article shows several examples of algorithms developed in graphical programming interface including the non-Cartesian MR reconstruction algorithms for PROPELLER and spiral as well as spin simulation and trajectory visualization of a FLORET example. The graphical programming interface framework is shown to be a versatile prototyping environment for developing numeric algorithms used in the latest MR techniques. © 2014 Wiley Periodicals, Inc.

Packaging printed circuit boards: A production application of interactive graphics

NASA Technical Reports Server (NTRS)

Perrill, W. A.

1975-01-01

The structure and use of an Interactive Graphics Packaging Program (IGPP), conceived to apply computer graphics to the design of packaging electronic circuits onto printed circuit boards (PCB), were described. The intent was to combine the data storage and manipulative power of the computer with the imaginative, intuitive power of a human designer. The hardware includes a CDC 6400 computer and two CDC 777 terminals with CRT screens, light pens, and keyboards. The program is written in FORTRAN 4 extended with the exception of a few functions coded in COMPASS (assembly language). The IGPP performs four major functions for the designer: (1) data input and display, (2) component placement (automatic or manual), (3) conductor path routing (automatic or manual), and (4) data output. The most complex PCB packaged to date measured 16.5 cm by 19 cm and contained 380 components, two layers of ground planes and four layers of conductors mixed with ground planes.

75 FR 28076 - New Postal Products

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

...) contracts.\\1\\ The Postal Service believes the instant contracts are functionally equivalent to previously..., which established GEPS 1 as a product, also authorized functionally equivalent agreements to be included... of Four Functionally Equivalent Global Expedited Package Services 2 Negotiated Service Agreements and...

75 FR 22633 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

...) contracts.\\1\\ The Postal Service believes the instant contracts are functionally equivalent to previously..., which established GEPS 1 as a product, also authorized functionally equivalent agreements to be included... Filing of Two Functionally Equivalent Global Expedited Package Services 2 Negotiated Service Agreements...

75 FR 53002 - New Postal Products

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... contracts are functionally equivalent to previously submitted GEPS contracts, and are supported by Governors... authorized functionally equivalent agreements to be included within the product, provided that they meet the... Functionally Equivalent Global Expedited Package Services 3 Negotiated Service Agreements and Application for...

75 FR 25303 - New Postal Products

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-07

... believes the instant contracts are functionally equivalent to previously submitted GEPS 2 contracts, and... GEPS 1 as a product, also authorized functionally equivalent agreements to be included within the... Functionally Equivalent Global Expedited Package Services 2 Negotiated Service Agreements and Application for...

Improving the Comprehension of Students with Significant Developmental Disabilities: Systematic Instruction on the Steps for Completing and Using a Graphic Organizer

ERIC Educational Resources Information Center

Britt, Alexander P.

2015-01-01

A single-subject, multiple-baseline across participants design was used to examine the functional relation between systematic instruction and the ability to complete a graphic organizer and recall facts about informational texts by students with significant development disabilities. Four high school students enrolled in an adapted academic program…

Procurement specification color graphic camera system

NASA Technical Reports Server (NTRS)

Prow, G. E.

1980-01-01

The performance and design requirements for a Color Graphic Camera System are presented. The system is a functional part of the Earth Observation Department Laboratory System (EODLS) and will be interfaced with Image Analysis Stations. It will convert the output of a raster scan computer color terminal into permanent, high resolution photographic prints and transparencies. Images usually displayed will be remotely sensed LANDSAT imager scenes.

SAMO (Sistema de Apoyo Mechanizado a la Operacion): An operational aids computer system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stormer, T.D.; Laflor, E.V.

1989-01-01

SAMO (Sistema de Apoyo Mechanizado a la Operacion) is a sensor-driven, computer-based, graphic display system designed by Westinghouse to aid the A. N. Asco operations staff during all modes of plant operations, including emergencies. The SAMO system is being implemented in the A. N. Asco plant in two phases that coincide with consecutive refueling outages for each of two nuclear units at the Asco site. Phase 1 of the SAMO system implements the following functions: (1) emergency operational aids, (2) postaccident monitoring, (3) plant graphics display, (4) high-speed transient analysis recording, (5) historical data collection, storage, and retrieval, (6) sequencemore » of events, and (7) posttrip review. During phase 2 of the SAMO project, the current plant computer will be removed and the functions now performed by the plant computer will be performed by the SAMO system. In addition, the following functions will be implemented: (1) normal and simple transients operational aid, (2) plant information graphics; and (3) real-time radiological off-site dose calculation.« less

[Effects of Electric Stimulation and Biofeedback for Pelvic Floor Muscle Exercise in Women with Vaginal Rejuvenation Women].

PubMed

Lee, Jung Bok; Choi, So Young

2015-10-01

The purpose of this study was to investigate the effects of pelvic floor muscle exercise using electric stimulation and biofeedback on maximum pressure of vaginal contraction, vaginal contraction duration and sexual function in women who have had vaginal rejuvenation. The research design was a non-equivalent control group non-synchronized design study. Participants in this study were women who had vaginal rejuvenation at C obstetrics and gynecology hospital. The 15 participants in the experimental group were given pelvic floor muscle exercise using electric stimulation and biofeedback and the 15 participants in the control group received self pelvic floor muscle exercise. For maximum pressure of vaginal contraction, the experimental group showed a statistically significant increase compared to than the control group (t=5.96, p<.001). For vaginal contraction duration, the experimental group also showed a statistically significant increase compared to the control group (t=3.23, p=.003). For women's sexual function, the experimental group showed a significant increase when compared to the control group in total sexual function scores (t=3.41, p=.002). The results indicate that pelvic floor muscle exercise with electric stimulation and biofeedback after vaginal rejuvenation is effective in strengthening vaginal contraction pressure, vaginal contraction and that it also positively functions to increase women's sexual function.

77 FR 16568 - International Mail Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

...-filed Postal Service request to enter into an additional International Business Reply Service contract... additional International Business Reply Service (IBRS) contract.\\1\\ The Postal Service asserts that the... Service Filing of a Functionally Equivalent International Business Reply Service Competitive Contract 3...

Raster graphics display library

NASA Technical Reports Server (NTRS)

Grimsrud, Anders; Stephenson, Michael B.

1987-01-01

The Raster Graphics Display Library (RGDL) is a high level subroutine package that give the advanced raster graphics display capabilities needed. The RGDL uses FORTRAN source code routines to build subroutines modular enough to use as stand-alone routines in a black box type of environment. Six examples are presented which will teach the use of RGDL in the fastest, most complete way possible. Routines within the display library that are used to produce raster graphics are presented in alphabetical order, each on a separate page. Each user-callable routine is described by function and calling parameters. All common blocks that are used in the display library are listed and the use of each variable within each common block is discussed. A reference on the include files that are necessary to compile the display library is contained. Each include file and its purpose are listed. The link map for MOVIE.BYU version 6, a general purpose computer graphics display system that uses RGDL software, is also contained.

Communication: A reduced scaling J-engine based reformulation of SOS-MP2 using graphics processing units

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maurer, S. A.; Kussmann, J.; Ochsenfeld, C., E-mail: Christian.Ochsenfeld@cup.uni-muenchen.de

2014-08-07

We present a low-prefactor, cubically scaling scaled-opposite-spin second-order Møller-Plesset perturbation theory (SOS-MP2) method which is highly suitable for massively parallel architectures like graphics processing units (GPU). The scaling is reduced from O(N{sup 5}) to O(N{sup 3}) by a reformulation of the MP2-expression in the atomic orbital basis via Laplace transformation and the resolution-of-the-identity (RI) approximation of the integrals in combination with efficient sparse algebra for the 3-center integral transformation. In contrast to previous works that employ GPUs for post Hartree-Fock calculations, we do not simply employ GPU-based linear algebra libraries to accelerate the conventional algorithm. Instead, our reformulation allows tomore » replace the rate-determining contraction step with a modified J-engine algorithm, that has been proven to be highly efficient on GPUs. Thus, our SOS-MP2 scheme enables us to treat large molecular systems in an accurate and efficient manner on a single GPU-server.« less

Effect of Contract Compliance Rate to a Fourth-Generation Telehealth Program on the Risk of Hospitalization in Patients With Chronic Kidney Disease: Retrospective Cohort Study.

PubMed

Hung, Chi-Sheng; Lee, Jenkuang; Chen, Ying-Hsien; Huang, Ching-Chang; Wu, Vin-Cent; Wu, Hui-Wen; Chuang, Pao-Yu; Ho, Yi-Lwun

2018-01-24

Chronic kidney disease (CKD) is prevalent in Taiwan and it is associated with high all-cause mortality. We have shown in a previous paper that a fourth-generation telehealth program is associated with lower all-cause mortality compared to usual care with a hazard ratio of 0.866 (95% CI 0.837-0.896). This study aimed to evaluate the effect of renal function status on hospitalization among patients receiving this program and to evaluate the relationship between contract compliance rate to the program and risk of hospitalization in patients with CKD. We retrospectively analyzed 715 patients receiving the telehealth care program. Contract compliance rate was defined as the percentage of days covered by the telehealth service before hospitalization. Patients were stratified into three groups according to renal function status: (1) normal renal function, (2) CKD, or (3) end-stage renal disease (ESRD) and on maintenance dialysis. The outcome measurements were first cardiovascular and all-cause hospitalizations. The association between contract compliance rate, renal function status, and hospitalization risk was analyzed with a Cox proportional hazards model with time-dependent covariates. The median follow-up duration was 694 days (IQR 338-1163). Contract compliance rate had a triphasic relationship with cardiovascular and all-cause hospitalizations. Patients with low or very high contract compliance rates were associated with a higher risk of hospitalization. Patients with CKD or ESRD were also associated with a higher risk of hospitalization. Moreover, we observed a significant interaction between the effects of renal function status and contract compliance rate on the risk of hospitalization: patients with ESRD, who were on dialysis, had an increased risk of hospitalization at a lower contract compliance rate, compared with patients with normal renal function or CKD. Our study showed that there was a triphasic relationship between contract compliance rate to the telehealth program and risk of hospitalization. Renal function status was associated with risk of hospitalization among these patients, and there was a significant interaction with contract compliance rate. ©Chi-Sheng Hung, Jenkuang Lee, Ying-Hsien Chen, Ching-Chang Huang, Vin-Cent Wu, Hui-Wen Wu, Pao-Yu Chuang, Yi-Lwun Ho. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 24.01.2018.

TU-D-209-03: Alignment of the Patient Graphic Model Using Fluoroscopic Images for Skin Dose Mapping

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oines, A; Oines, A; Kilian-Meneghin, J

2016-06-15

Purpose: The Dose Tracking System (DTS) was developed to provide realtime feedback of skin dose and dose rate during interventional fluoroscopic procedures. A color map on a 3D graphic of the patient represents the cumulative dose distribution on the skin. Automated image correlation algorithms are described which use the fluoroscopic procedure images to align and scale the patient graphic for more accurate dose mapping. Methods: Currently, the DTS employs manual patient graphic selection and alignment. To improve the accuracy of dose mapping and automate the software, various methods are explored to extract information about the beam location and patient morphologymore » from the procedure images. To match patient anatomy with a reference projection image, preprocessing is first used, including edge enhancement, edge detection, and contour detection. Template matching algorithms from OpenCV are then employed to find the location of the beam. Once a match is found, the reference graphic is scaled and rotated to fit the patient, using image registration correlation functions in Matlab. The algorithm runs correlation functions for all points and maps all correlation confidences to a surface map. The highest point of correlation is used for alignment and scaling. The transformation data is saved for later model scaling. Results: Anatomic recognition is used to find matching features between model and image and image registration correlation provides for alignment and scaling at any rotation angle with less than onesecond runtime, and at noise levels in excess of 150% of those found in normal procedures. Conclusion: The algorithm provides the necessary scaling and alignment tools to improve the accuracy of dose distribution mapping on the patient graphic with the DTS. Partial support from NIH Grant R01-EB002873 and Toshiba Medical Systems Corp.« less

48 CFR 3.1103 - Procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Contractor Employees Performing Acquisition Functions 3.1103 Procedures. (a) By use of the contract clause at... employees perform acquisition functions closely associated with inherently Government functions to— (1) Have... information accessed through performance of a Government contract for personal gain; and (iii) Obtain a signed...

48 CFR 3.1103 - Procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Contractor Employees Performing Acquisition Functions 3.1103 Procedures. (a) By use of the contract clause at... employees perform acquisition functions closely associated with inherently Government functions to— (1) Have... information accessed through performance of a Government contract for personal gain; and (iii) Obtain a signed...

48 CFR 3.1103 - Procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Contractor Employees Performing Acquisition Functions 3.1103 Procedures. (a) By use of the contract clause at... employees perform acquisition functions closely associated with inherently Government functions to— (1) Have... information accessed through performance of a Government contract for personal gain; and (iii) Obtain a signed...

Atlas/Data Abstract for the United States and Selected Areas. Fiscal Year 1989

DTIC Science & Technology

1989-01-01

are generally reported at the i t where the work is performed. For example. if a con :ac or located in Nevada and wins a construction )ot! in Utah, tl...0 4l?~.5 1’".t� Service Contracts 24. j𔃾. . 1 , :of,;t) j , 467, 4X Construction Contrac.ts 3, f5’ Ś). 12,tf.;9" Z3),t); 6,:16 Civil Function...Contracts 237,277 58,434 22,106 148,375 8,362 Construction Contracts 162,202 113,971 48,231 0 0 Civil Function Contracts 17,458 17,458 0 0 0

Training-specific functional, neural, and hypertrophic adaptations to explosive- vs. sustained-contraction strength training.

PubMed

Balshaw, Thomas G; Massey, Garry J; Maden-Wilkinson, Thomas M; Tillin, Neale A; Folland, Jonathan P

2016-06-01

Training specificity is considered important for strength training, although the functional and underpinning physiological adaptations to different types of training, including brief explosive contractions, are poorly understood. This study compared the effects of 12 wk of explosive-contraction (ECT, n = 13) vs. sustained-contraction (SCT, n = 16) strength training vs. control (n = 14) on the functional, neural, hypertrophic, and intrinsic contractile characteristics of healthy young men. Training involved 40 isometric knee extension repetitions (3 times/wk): contracting as fast and hard as possible for ∼1 s (ECT) or gradually increasing to 75% of maximum voluntary torque (MVT) before holding for 3 s (SCT). Torque and electromyography during maximum and explosive contractions, torque during evoked octet contractions, and total quadriceps muscle volume (QUADSVOL) were quantified pre and post training. MVT increased more after SCT than ECT [23 vs. 17%; effect size (ES) = 0.69], with similar increases in neural drive, but greater QUADSVOL changes after SCT (8.1 vs. 2.6%; ES = 0.74). ECT improved explosive torque at all time points (17-34%; 0.54 ≤ ES ≤ 0.76) because of increased neural drive (17-28%), whereas only late-phase explosive torque (150 ms, 12%; ES = 1.48) and corresponding neural drive (18%) increased after SCT. Changes in evoked torque indicated slowing of the contractile properties of the muscle-tendon unit after both training interventions. These results showed training-specific functional changes that appeared to be due to distinct neural and hypertrophic adaptations. ECT produced a wider range of functional adaptations than SCT, and given the lesser demands of ECT, this type of training provides a highly efficient means of increasing function. Copyright © 2016 the American Physiological Society.

Model aerodynamic test results for two variable cycle engine coannular exhaust systems at simulated takeoff and cruise conditions. Comprehensive data report. Volume 3: Graphical data book 1

NASA Technical Reports Server (NTRS)

Nelson, D. P.

1981-01-01

A graphical presentation of the aerodynamic data acquired during coannular nozzle performance wind tunnel tests is given. The graphical data consist of plots of nozzle gross thrust coefficient, fan nozzle discharge coefficient, and primary nozzle discharge coefficient. Normalized model component static pressure distributions are presented as a function of primary total pressure, fan total pressure, and ambient static pressure for selected operating conditions. In addition, the supersonic cruise configuration data include plots of nozzle efficiency and secondary-to-fan total pressure pumping characteristics. Supersonic and subsonic cruise data are given.

Interactive computer programs for the graphic analysis of nucleotide sequence data.

PubMed Central

Luckow, V A; Littlewood, R K; Rownd, R H

1984-01-01

A group of interactive computer programs have been developed which aid in the collection and graphical analysis of nucleotide and protein sequence data. The programs perform the following basic functions: a) enter, edit, list, and rearrange sequence data; b) permit automatic entry of nucleotide sequence data directly from an autoradiograph into the computer; c) search for restriction sites or other specified patterns and plot a linear or circular restriction map, or print their locations; d) plot base composition; e) analyze homology between sequences by plotting a two-dimensional graphic matrix; and f) aid in plotting predicted secondary structures of RNA molecules. PMID:6546437

Fortran graphics routines for the Macintosh

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shore, B.W.

1992-06-01

The Language Systems MPW Fortran is a popular Fortran compiler for the Macintosh. Unfortunately, it does not have any built-in calls to graphics routines (such as are available with Graflib on the NLTSS), so there is no simple way to make x-y plots from calls within Fortran. Instead, a file of data must be created and a commercial plotting routine (such as IGOR or KALEIDAGRAPH) or a spreadsheet with graphics (such as WINGZ) must be applied to post-process the data. The Macintosh does have available many built-in calls (to the Macintosh Toolbox) that allow drawing shapes and lines with quickdraw,more » but these are not designed for plotting functions and are difficult to learn to use. This work outlines some Fortran routines that can be called from LS Fortran to make the necessary calls to the Macintosh toolbox to create simple two-dimensional plots or contour plots. The source code DEMOGRAF.F shows how these routines may be used. DEMOGRAF.F simply demonstrates some Fortran subroutines that can be called with language systems MPW Fortran on the Macintosh to plot arrays of numbers. The subroutines essentially mimic the functionality that has been available at LTSS and NLTSS and UNICOS at LLNL. The graphics primitives are kept in four separate files, each containing several subroutines. The subroutines are compiled and stored in a library file, LIBgraf.o. Makefile is used to link this library to the source code. A discussion is included on requirements for interactive plotting of functions.« less

Exploring Nonroutine Functions Algebraically and Graphically

ERIC Educational Resources Information Center

Trinter, Christine P.; Garofalo, Joe

2011-01-01

Nonroutine function tasks are more challenging than most typical high school mathematics tasks. Nonroutine tasks encourage students to expand their thinking about functions and their approaches to problem solving. As a result, they gain greater appreciation for the power of multiple representations and a richer understanding of functions. This…

The influence of the parents' educational level on the development of executive functions.

PubMed

Ardila, Alfredo; Rosselli, Monica; Matute, Esmeralda; Guajardo, Soledad

2005-01-01

Information about the influence of educational variables on the development of executive functions is limited. The aim of this study was to analyze the relation of the parents' educational level and the type of school the child attended (private or public school) to children's executive functioning test performance. Six hundred twenty-two participants, ages 5 to 14 years (276 boys, 346 girls) were selected from Colombia and Mexico and grouped according to three variables: age (5-6, 7-8, 9-10, 11-12, and 13-14 years), gender (boys and girls), and school type (private and public). Eight executive functioning tests taken from the Evaluacion Neuropsicologica Infantil; Matute, Rosselli, Ardila, & Ostrosky, (in press) were individually administered: Semantic Verbal Fluency, Phonemic Verbal Fluency, Semantic Graphic Fluency, Nonsemantic Graphic Fluency, Matrices, Similarities, Card Sorting, and the Mexican Pyramid. There was a significant effect of age on all the test scores and a significant effect of type of school attended on all but Semantic Verbal Fluency and Nonsemantic Graphic Fluency tests. Most children's test scores, particularly verbal test scores, significantly correlated with parents' educational level. Our results suggest that the differences in test scores between the public and private school children depended on some conditions existing outside the school, such as the parents' level of education. Implications of these findings for the understanding of the influence of environmental factors on the development of executive functions are presented.

PLOT3D/AMES, APOLLO UNIX VERSION USING GMR3D (WITHOUT TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The Apollo implementation of PLOT3D uses some of the capabilities of Apollo's 3-dimensional graphics hardware, but does not take advantage of the shading and hidden line/surface removal capabilities of the Apollo DN10000. Although this implementation does not offer a capability for putting text on plots, it does support the use of a mouse to translate, rotate, or zoom in on views. The version 3.6b+ Apollo implementations of PLOT3D (ARC-12789) and PLOT3D/TURB3D (ARC-12785) were developed for use on Apollo computers running UNIX System V with BSD 4.3 extensions and the graphics library GMR3D Version 2.0. The standard distribution media for each of these programs is a 9-track, 6250 bpi magnetic tape in TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: 1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); 2) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC-12777, ARC-12781); 3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstations (ARC-12783, ARC-12782). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

PLOT3D/AMES, SGI IRIS VERSION (WITHOUT TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. In each of these areas, the IRIS implementation of PLOT3D offers advanced features which aid visualization efforts. Shading and hidden line/surface removal can be used to enhance depth perception and other aspects of the graphical displays. A mouse can be used to translate, rotate, or zoom in on views. Files for several types of output can be produced. Two animation options are even offered: creation of simple animation sequences without the need for other software; and, creation of files for use in GAS (Graphics Animation System, ARC-12379), an IRIS program which offers more complex rendering and animation capabilities and can record images to digital disk, video tape, or 16-mm film. The version 3.6b+ SGI implementations of PLOT3D (ARC-12783) and PLOT3D/TURB3D (ARC-12782) were developed for use on Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstations. These programs are each distributed on one .25 inch magnetic tape cartridge in IRIS TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC-12777,ARC-12781); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

PLOT3D/AMES, APOLLO UNIX VERSION USING GMR3D (WITH TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The Apollo implementation of PLOT3D uses some of the capabilities of Apollo's 3-dimensional graphics hardware, but does not take advantage of the shading and hidden line/surface removal capabilities of the Apollo DN10000. Although this implementation does not offer a capability for putting text on plots, it does support the use of a mouse to translate, rotate, or zoom in on views. The version 3.6b+ Apollo implementations of PLOT3D (ARC-12789) and PLOT3D/TURB3D (ARC-12785) were developed for use on Apollo computers running UNIX System V with BSD 4.3 extensions and the graphics library GMR3D Version 2.0. The standard distribution media for each of these programs is a 9-track, 6250 bpi magnetic tape in TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: 1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); 2) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC-12777, ARC-12781); 3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstations (ARC-12783, ARC-12782). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

PLOT3D/AMES, SGI IRIS VERSION (WITH TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. In each of these areas, the IRIS implementation of PLOT3D offers advanced features which aid visualization efforts. Shading and hidden line/surface removal can be used to enhance depth perception and other aspects of the graphical displays. A mouse can be used to translate, rotate, or zoom in on views. Files for several types of output can be produced. Two animation options are even offered: creation of simple animation sequences without the need for other software; and, creation of files for use in GAS (Graphics Animation System, ARC-12379), an IRIS program which offers more complex rendering and animation capabilities and can record images to digital disk, video tape, or 16-mm film. The version 3.6b+ SGI implementations of PLOT3D (ARC-12783) and PLOT3D/TURB3D (ARC-12782) were developed for use on Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstations. These programs are each distributed on one .25 inch magnetic tape cartridge in IRIS TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC-12777,ARC-12781); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.

PubMed

Hwang, Hyundoo; Barnes, Dawn E; Matsunaga, Yohei; Benian, Guy M; Ono, Shoichiro; Lu, Hang

2016-01-29

The sarcomere, the fundamental unit of muscle contraction, is a highly-ordered complex of hundreds of proteins. Despite decades of genetics work, the functional relationships and the roles of those sarcomeric proteins in animal behaviors remain unclear. In this paper, we demonstrate that optogenetic activation of the motor neurons that induce muscle contraction can facilitate quantitative studies of muscle kinetics in C. elegans. To increase the throughput of the study, we trapped multiple worms in parallel in a microfluidic device and illuminated for photoactivation of channelrhodopsin-2 to induce contractions in body wall muscles. Using image processing, the change in body size was quantified over time. A total of five parameters including rate constants for contraction and relaxation were extracted from the optogenetic assay as descriptors of sarcomere functions. To potentially relate the genes encoding the sarcomeric proteins functionally, a hierarchical clustering analysis was conducted on the basis of those parameters. Because it assesses physiological output different from conventional assays, this method provides a complement to the phenotypic analysis of C. elegans muscle mutants currently performed in many labs; the clusters may provide new insights and drive new hypotheses for functional relationships among the many sarcomere components.

Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans

NASA Astrophysics Data System (ADS)

Hwang, Hyundoo; Barnes, Dawn E.; Matsunaga, Yohei; Benian, Guy M.; Ono, Shoichiro; Lu, Hang

2016-01-01

The sarcomere, the fundamental unit of muscle contraction, is a highly-ordered complex of hundreds of proteins. Despite decades of genetics work, the functional relationships and the roles of those sarcomeric proteins in animal behaviors remain unclear. In this paper, we demonstrate that optogenetic activation of the motor neurons that induce muscle contraction can facilitate quantitative studies of muscle kinetics in C. elegans. To increase the throughput of the study, we trapped multiple worms in parallel in a microfluidic device and illuminated for photoactivation of channelrhodopsin-2 to induce contractions in body wall muscles. Using image processing, the change in body size was quantified over time. A total of five parameters including rate constants for contraction and relaxation were extracted from the optogenetic assay as descriptors of sarcomere functions. To potentially relate the genes encoding the sarcomeric proteins functionally, a hierarchical clustering analysis was conducted on the basis of those parameters. Because it assesses physiological output different from conventional assays, this method provides a complement to the phenotypic analysis of C. elegans muscle mutants currently performed in many labs; the clusters may provide new insights and drive new hypotheses for functional relationships among the many sarcomere components.

40 CFR 35.938-5 - Negotiation of contract amendments (change orders).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Negotiation of contract amendments...-Clean Water Act § 35.938-5 Negotiation of contract amendments (change orders). (a) Grantee responsibility. Grantees are responsible for negotiation of construction contract change orders. This function...

40 CFR 35.938-5 - Negotiation of contract amendments (change orders).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Negotiation of contract amendments...-Clean Water Act § 35.938-5 Negotiation of contract amendments (change orders). (a) Grantee responsibility. Grantees are responsible for negotiation of construction contract change orders. This function...

40 CFR 35.938-5 - Negotiation of contract amendments (change orders).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Negotiation of contract amendments...-Clean Water Act § 35.938-5 Negotiation of contract amendments (change orders). (a) Grantee responsibility. Grantees are responsible for negotiation of construction contract change orders. This function...

40 CFR 35.938-5 - Negotiation of contract amendments (change orders).

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Negotiation of contract amendments...-Clean Water Act § 35.938-5 Negotiation of contract amendments (change orders). (a) Grantee responsibility. Grantees are responsible for negotiation of construction contract change orders. This function...

40 CFR 35.938-5 - Negotiation of contract amendments (change orders).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Negotiation of contract amendments...-Clean Water Act § 35.938-5 Negotiation of contract amendments (change orders). (a) Grantee responsibility. Grantees are responsible for negotiation of construction contract change orders. This function...

48 CFR 552.219-74 - Section 8(a) Direct Award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracting activity shall give advance notice to SBA before it issues a final notice terminating performance... prior to processing any advance payments or novation agreements. The contracting activity may assign contract administration functions to a contract administration office. (c) The Contractor agrees: (1) To...

48 CFR 3052.242-72 - Contracting officer's technical representative.

Code of Federal Regulations, 2010 CFR

2010-10-01

... functions of a technical nature. The Contracting Officer will provide a written notice of such designation... technical representative. 3052.242-72 Section 3052.242-72 Federal Acquisition Regulations System DEPARTMENT... PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 3052.242-72 Contracting officer's technical...

14 CFR 145.217 - Contract maintenance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Contract maintenance. 145.217 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.217 Contract maintenance. (a) A certificated repair station may contract a maintenance function pertaining to an article to an...

A Measurement of AFIT Contracting and Acquisition Management Program Usefulness as Perceived by Graduates and Their Supervisors.

DTIC Science & Technology

1982-09-01

21 functions. The legal category covers the business, commer- cial and contract law fields, including patents and royalties, technical data, claims...Course Rankings Question # Subject Area Median Rank 55,56,59 Contract Management Theory 7.0 1 53,54 Contract Law 6.5 2 So Contracting & Acquis. Mgt...respondents ranked Contract Management Theory as the most useful course among all courses in the AFIT CAM curriculum. Graduates ranked Contract Law as

Mass Spectrometry of Single GABAergic Somatic Motorneurons Identifies a Novel Inhibitory Peptide, As-NLP-22, in the Nematode Ascaris suum.

PubMed

Konop, Christopher J; Knickelbine, Jennifer J; Sygulla, Molly S; Wruck, Colin D; Vestling, Martha M; Stretton, Antony O W

2015-12-01

Neuromodulators have become an increasingly important component of functional circuits, dramatically changing the properties of both neurons and synapses to affect behavior. To explore the role of neuropeptides in Ascaris suum behavior, we devised an improved method for cleanly dissecting single motorneuronal cell bodies from the many other cell processes and hypodermal tissue in the ventral nerve cord. We determined their peptide content using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). The reduced complexity of the peptide mixture greatly aided the detection of peptides; peptide levels were sufficient to permit sequencing by tandem MS from single cells. Inhibitory motorneurons, known to be GABAergic, contain a novel neuropeptide, As-NLP-22 (SLASGRWGLRPamide). From this sequence and information from the A. suum expressed sequence tag (EST) database, we cloned the transcript (As-nlp-22) and synthesized a riboprobe for in situ hybridization, which labeled the inhibitory motorneurons; this validates the integrity of the dissection method, showing that the peptides detected originate from the cells themselves and not from adhering processes from other cells (e.g., synaptic terminals). Synthetic As-NLP-22 has potent inhibitory activity on acetylcholine-induced muscle contraction as well as on basal muscle tone. Both of these effects are dose-dependent: the inhibitory effect on ACh contraction has an IC50 of 8.3 × 10(-9) M. When injected into whole worms, As-NLP-22 produces a dose-dependent inhibition of locomotory movements and, at higher levels, complete paralysis. These experiments demonstrate the utility of MALDI TOF/TOF MS in identifying novel neuromodulators at the single-cell level. Graphical Abstract ᅟ.

48 CFR 52.223-13 - Acquisition of EPEAT®-Registered Imaging Equipment.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) Facsimile machine (fax machine)—A commercially available imaging product whose primary functions are... available imaging product with a sole function of the production of hard copy duplicates from graphic hard... functionally integrated components, that performs two or more of the core functions of copying, printing...

Sharing Teaching Ideas.

ERIC Educational Resources Information Center

Touval, Ayana

1992-01-01

Introduces the concept of maximum and minimum function values as turning points on the function's graphic representation and presents a method for finding these values without using calculus. The process of utilizing transformations to find the turning point of a quadratic function is extended to find the turning points of cubic functions. (MDH)

Graphics supercomputer for computational fluid dynamics research

NASA Astrophysics Data System (ADS)

Liaw, Goang S.

1994-11-01

The objective of this project is to purchase a state-of-the-art graphics supercomputer to improve the Computational Fluid Dynamics (CFD) research capability at Alabama A & M University (AAMU) and to support the Air Force research projects. A cutting-edge graphics supercomputer system, Onyx VTX, from Silicon Graphics Computer Systems (SGI), was purchased and installed. Other equipment including a desktop personal computer, PC-486 DX2 with a built-in 10-BaseT Ethernet card, a 10-BaseT hub, an Apple Laser Printer Select 360, and a notebook computer from Zenith were also purchased. A reading room has been converted to a research computer lab by adding some furniture and an air conditioning unit in order to provide an appropriate working environments for researchers and the purchase equipment. All the purchased equipment were successfully installed and are fully functional. Several research projects, including two existing Air Force projects, are being performed using these facilities.

TAIGA: Twente Advanced Interactive Graphic Authoring System. A New Concept in Computer Assisted Learning (CAL) and Educational Research. Doc 88-18.

ERIC Educational Resources Information Center

Pilot, A.

TAIGA (Twente Advanced Interactive Graphic Authoring system) is a system which can be used to develop instructional software. It is written in MS-PASCAL, and runs on computers that support MS-DOS. Designed to support the production of structured software, TAIGA has a hierarchical structure of three layers, each with a specific function, and each…

The Sigma Cognitive Architecture and System: Towards Functionally Elegant Grand Unification

NASA Astrophysics Data System (ADS)

Rosenbloom, Paul S.; Demski, Abram; Ustun, Volkan

2016-12-01

Sigma (Σ) is a cognitive architecture and system whose development is driven by a combination of four desiderata: grand unification, generic cognition, functional elegance, and sufficient efficiency. Work towards these desiderata is guided by the graphical architecture hypothesis, that key to progress on them is combining what has been learned from over three decades' worth of separate work on cognitive architectures and graphical models. In this article, these four desiderata are motivated and explained, and then combined with the graphical architecture hypothesis to yield a rationale for the development of Sigma. The current state of the cognitive architecture is then introduced in detail, along with the graphical architecture that sits below it and implements it. Progress in extending Sigma beyond these architectures and towards a full cognitive system is then detailed in terms of both a systematic set of higher level cognitive idioms that have been developed and several virtual humans that are built from combinations of these idioms. Sigma as a whole is then analyzed in terms of how well the progress to date satisfies the desiderata. This article thus provides the first full motivation, presentation and analysis of Sigma, along with a diversity of more specific results that have been generated during its development.

PLOT3D/AMES, UNIX SUPERCOMPUTER AND SGI IRIS VERSION (WITHOUT TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. In addition to providing the advantages of performing complex calculations on a supercomputer, the Supercomputer/IRIS implementation of PLOT3D offers advanced 3-D, view manipulation, and animation capabilities. Shading and hidden line/surface removal can be used to enhance depth perception and other aspects of the graphical displays. A mouse can be used to translate, rotate, or zoom in on views. Files for several types of output can be produced. Two animation options are available. Simple animation sequences can be created on the IRIS, or,if an appropriately modified version of ARCGRAPH (ARC-12350) is accesible on the supercomputer, files can be created for use in GAS (Graphics Animation System, ARC-12379), an IRIS program which offers more complex rendering and animation capabilities and options for recording images to digital disk, video tape, or 16-mm film. The version 3.6b+ Supercomputer/IRIS implementations of PLOT3D (ARC-12779) and PLOT3D/TURB3D (ARC-12784) are suitable for use on CRAY 2/UNICOS, CONVEX, and ALLIANT computers with a remote Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstation. These programs are distributed on .25 inch magnetic tape cartridges in IRIS TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstations (ARC-12783, ARC-12782); (2) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC12777, ARC-12781); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 - which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo, DN10000, and GMR3D are trademarks of Hewlett-Packard, Incorporated. System V is a trademark of Bell Labs, Incorporated. BSD4.3 is a trademark of the University of California at Berkeley. UNIX is a registered trademark of AT&T.

PLOT3D/AMES, UNIX SUPERCOMPUTER AND SGI IRIS VERSION (WITH TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. In addition to providing the advantages of performing complex calculations on a supercomputer, the Supercomputer/IRIS implementation of PLOT3D offers advanced 3-D, view manipulation, and animation capabilities. Shading and hidden line/surface removal can be used to enhance depth perception and other aspects of the graphical displays. A mouse can be used to translate, rotate, or zoom in on views. Files for several types of output can be produced. Two animation options are available. Simple animation sequences can be created on the IRIS, or,if an appropriately modified version of ARCGRAPH (ARC-12350) is accesible on the supercomputer, files can be created for use in GAS (Graphics Animation System, ARC-12379), an IRIS program which offers more complex rendering and animation capabilities and options for recording images to digital disk, video tape, or 16-mm film. The version 3.6b+ Supercomputer/IRIS implementations of PLOT3D (ARC-12779) and PLOT3D/TURB3D (ARC-12784) are suitable for use on CRAY 2/UNICOS, CONVEX, and ALLIANT computers with a remote Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstation. These programs are distributed on .25 inch magnetic tape cartridges in IRIS TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D workstations (ARC-12783, ARC-12782); (2) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC12777, ARC-12781); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 - which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo, DN10000, and GMR3D are trademarks of Hewlett-Packard, Incorporated. System V is a trademark of Bell Labs, Incorporated. BSD4.3 is a trademark of the University of California at Berkeley. UNIX is a registered trademark of AT&T.

An interactive graphics program for manipulation and display of panel method geometry

NASA Technical Reports Server (NTRS)

Hall, J. F.; Neuhart, D. H.; Walkley, K. B.

1983-01-01

Modern aerodynamic panel methods that handle large, complex geometries have made evident the need to interactively manipulate, modify, and view such configurations. With this purpose in mind, the GEOM program was developed. It is a menu driven, interactive program that uses the Tektronix PLOT 10 graphics software to display geometry configurations which are characterized by an abutting set of networks. These networks are composed of quadrilateral panels which are described by the coordinates of their corners. GEOM is divided into fourteen executive controlled functions. These functions are used to build configurations, scale and rotate networks, transpose networks defining M and N lines, graphically display selected networks, join and split networks, create wake networks, produce symmetric images of networks, repanel and rename networks, display configuration cross sections, and output network geometry in two formats. A data base management system is used to facilitate data transfers in this program. A sample session illustrating various capabilities of the code is included as a guide to program operation.

The Real Time Display Builder (RTDB)

NASA Technical Reports Server (NTRS)

Kindred, Erick D.; Bailey, Samuel A., Jr.

1989-01-01

The Real Time Display Builder (RTDB) is a prototype interactive graphics tool that builds logic-driven displays. These displays reflect current system status, implement fault detection algorithms in real time, and incorporate the operational knowledge of experienced flight controllers. RTDB utilizes an object-oriented approach that integrates the display symbols with the underlying operational logic. This approach allows the user to specify the screen layout and the driving logic as the display is being built. RTDB is being developed under UNIX in C utilizing the MASSCOMP graphics environment with appropriate functional separation to ease portability to other graphics environments. RTDB grew from the need to develop customized real-time data-driven Space Shuttle systems displays. One display, using initial functionality of the tool, was operational during the orbit phase of STS-26 Discovery. RTDB is being used to produce subsequent displays for the Real Time Data System project currently under development within the Mission Operations Directorate at NASA/JSC. The features of the tool, its current state of development, and its applications are discussed.

Concomitant use of the matrix strategy and the mand-model procedure in teaching graphic symbol combinations.

PubMed

Nigam, Ravi; Schlosser, Ralf W; Lloyd, Lyle L

2006-09-01

Matrix strategies employing parts of speech arranged in systematic language matrices and milieu language teaching strategies have been successfully used to teach word combining skills to children who have cognitive disabilities and some functional speech. The present study investigated the acquisition and generalized production of two-term semantic relationships in a new population using new types of symbols. Three children with cognitive disabilities and little or no functional speech were taught to combine graphic symbols. The matrix strategy and the mand-model procedure were used concomitantly as intervention procedures. A multiple probe design across sets of action-object combinations with generalization probes of untrained combinations was used to teach the production of graphic symbol combinations. Results indicated that two of the three children learned the early syntactic-semantic rule of combining action-object symbols and demonstrated generalization to untrained action-object combinations and generalization across trainers. The results and future directions for research are discussed.

Inquiry-Based Learning of Transcendental Functions in Calculus

ERIC Educational Resources Information Center

Ekici, Celil; Gard, Andrew

2017-01-01

In a series of group activities supplemented with independent explorations and assignments, calculus students investigate functions similar to their own derivatives. Graphical, numerical, and algebraic perspectives are suggested, leading students to develop deep intuition into elementary transcendental functions even as they lay the foundation for…

48 CFR 6.502 - Duties and responsibilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... of functions to be performed, performance required or essential physical characteristics, and... burdensome contract clauses. (b) Agency competition advocates shall— (1) Review the contracting operations of... functions to be performed, performance required or essential physical characteristics; (iv) Any condition or...

DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor.

PubMed

Vonderach, Matthias; Byrne, Dominic P; Barran, Perdita E; Eyers, Patrick A; Eyers, Claire E

2018-06-05

The NF-κB transcription factors are known to be extensively phosphorylated, with dynamic site-specific modification regulating their ability to dimerize and interact with DNA. p50, the proteolytic product of p105 (NF-κB1), forms homodimers that bind DNA but lack intrinsic transactivation function, functioning as repressors of transcription from κB promoters. Here, we examine the roles of specific phosphorylation events catalysed by either protein kinase A (PKA c ) or Chk1, in regulating the functions of p50 homodimers. LC-MS/MS analysis of proteolysed p50 following in vitro phosphorylation allows us to define Ser328 and Ser337 as PKA c - and Chk1-mediated modifications, and pinpoint an additional four Chk1 phosphosites: Ser65, Thr152, Ser242 and Ser248. Native mass spectrometry (MS) reveals Chk1- and PKA c -regulated disruption of p50 homodimer formation through Ser337. Additionally, we characterise the Chk1-mediated phosphosite, Ser242, as a regulator of DNA binding, with a S242D p50 phosphomimetic exhibiting a > 10-fold reduction in DNA binding affinity. Conformational dynamics of phosphomimetic p50 variants, including S242D, are further explored using ion-mobility MS (IM-MS). Finally, comparative theoretical modelling with experimentally observed p50 conformers, in the absence and presence of DNA, reveals that the p50 homodimer undergoes conformational contraction during electrospray ionisation that is stabilised by complex formation with κB DNA. Graphical Abstract ᅟ.

Effect of hypokinesia on contractile function of cardiac muscle

NASA Technical Reports Server (NTRS)

Meyerson, F. Z.; Kapelko, V. I.; Trikhpoyeva, A. M.; Gorina, M. S.

1980-01-01

Rats were subjected to hypokinesia for two months and the contractile function of isolated papillary muscle was studied. Hypokinesia reduced significantly the isotonic contraction rate which depended on the ATPase activity of the myofibrils; it also reduced the rate and index of relaxation which depended on the functional capacity of the Ca(++) pump of the sarcoplasmic reticulum. The maximum force of isometric contraction determined by the quantity of actomyosin bridges in the myofibrils did not change after hypokinesia. This complex of changes is contrary to that observed in adaptation to exercise when the rate of isotonic contraction and relaxation increases while the force of isometric contraction does not change. The possible mechanism of this stability of the contractile force during adaptation and readaptation of the heart is discussed.

Visualization of synchronization of the uterine contraction signals: running cross-correlation and wavelet running cross-correlation methods.

PubMed

Oczeretko, Edward; Swiatecka, Jolanta; Kitlas, Agnieszka; Laudanski, Tadeusz; Pierzynski, Piotr

2006-01-01

In physiological research, we often study multivariate data sets, containing two or more simultaneously recorded time series. The aim of this paper is to present the cross-correlation and the wavelet cross-correlation methods to assess synchronization between contractions in different topographic regions of the uterus. From a medical point of view, it is important to identify time delays between contractions, which may be of potential diagnostic significance in various pathologies. The cross-correlation was computed in a moving window with a width corresponding to approximately two or three contractions. As a result, the running cross-correlation function was obtained. The propagation% parameter assessed from this function allows quantitative description of synchronization in bivariate time series. In general, the uterine contraction signals are very complicated. Wavelet transforms provide insight into the structure of the time series at various frequencies (scales). To show the changes of the propagation% parameter along scales, a wavelet running cross-correlation was used. At first, the continuous wavelet transforms as the uterine contraction signals were received and afterwards, a running cross-correlation analysis was conducted for each pair of transformed time series. The findings show that running functions are very useful in the analysis of uterine contractions.

Eccentric Contraction-Induced Muscle Injury: Reproducible, Quantitative, Physiological Models to Impair Skeletal Muscle’s Capacity to Generate Force

PubMed Central

Call, Jarrod A.; Lowe, Dawn A.

2018-01-01

In order to investigate the molecular and cellular mechanisms of muscle regeneration an experimental injury model is required. Advantages of eccentric contraction-induced injury are that it is a controllable, reproducible, and physiologically relevant model to cause muscle injury, with injury being defined as a loss of force generating capacity. While eccentric contractions can be incorporated into conscious animal study designs such as downhill treadmill running, electrophysiological approaches to elicit eccentric contractions and examine muscle contractility, for example before and after the injurious eccentric contractions, allows researchers to circumvent common issues in determining muscle function in a conscious animal (e.g., unwillingness to participate). Herein, we describe in vitro and in vivo methods that are reliable, repeatable, and truly maximal because the muscle contractions are evoked in a controlled, quantifiable manner independent of subject motivation. Both methods can be used to initiate eccentric contraction-induced injury and are suitable for monitoring functional muscle regeneration hours to days to weeks post-injury. PMID:27492161

OAP- OFFICE AUTOMATION PILOT GRAPHICS DATABASE SYSTEM

NASA Technical Reports Server (NTRS)

Ackerson, T.

1994-01-01

The Office Automation Pilot (OAP) Graphics Database system offers the IBM PC user assistance in producing a wide variety of graphs and charts. OAP uses a convenient database system, called a chartbase, for creating and maintaining data associated with the charts, and twelve different graphics packages are available to the OAP user. Each of the graphics capabilities is accessed in a similar manner. The user chooses creation, revision, or chartbase/slide show maintenance options from an initial menu. The user may then enter or modify data displayed on a graphic chart. The cursor moves through the chart in a "circular" fashion to facilitate data entries and changes. Various "help" functions and on-screen instructions are available to aid the user. The user data is used to generate the graphics portion of the chart. Completed charts may be displayed in monotone or color, printed, plotted, or stored in the chartbase on the IBM PC. Once completed, the charts may be put in a vector format and plotted for color viewgraphs. The twelve graphics capabilities are divided into three groups: Forms, Structured Charts, and Block Diagrams. There are eight Forms available: 1) Bar/Line Charts, 2) Pie Charts, 3) Milestone Charts, 4) Resources Charts, 5) Earned Value Analysis Charts, 6) Progress/Effort Charts, 7) Travel/Training Charts, and 8) Trend Analysis Charts. There are three Structured Charts available: 1) Bullet Charts, 2) Organization Charts, and 3) Work Breakdown Structure (WBS) Charts. The Block Diagram available is an N x N Chart. Each graphics capability supports a chartbase. The OAP graphics database system provides the IBM PC user with an effective means of managing data which is best interpreted as a graphic display. The OAP graphics database system is written in IBM PASCAL 2.0 and assembler for interactive execution on an IBM PC or XT with at least 384K of memory, and a color graphics adapter and monitor. Printed charts require an Epson, IBM, OKIDATA, or HP Laser printer (or equivalent). Plots require the Tektronix 4662 Penplotter. Source code is supplied to the user for modification and customizing. Executables are also supplied for all twelve graphics capabilities. This system was developed in 1983, and Version 3.1 was released in 1986.

PLOT3D/AMES, GENERIC UNIX VERSION USING DISSPLA (WITH TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The UNIX/DISSPLA implementation of PLOT3D supports 2-D polygons as well as 2-D and 3-D lines, but does not support graphics features requiring 3-D polygons (shading and hidden line removal, for example). Views can be manipulated using keyboard commands. This version of PLOT3D is potentially able to produce files for a variety of output devices; however, site-specific capabilities will vary depending on the device drivers supplied with the user's DISSPLA library. The version 3.6b+ UNIX/DISSPLA implementations of PLOT3D (ARC-12788) and PLOT3D/TURB3D (ARC-12778) were developed for use on computers running UNIX SYSTEM 5 with BSD 4.3 extensions. The standard distribution media for each ofthese programs is a 9track, 6250 bpi magnetic tape in TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D (ARC-12783, ARC-12782); (3) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC-12777, ARC-12781); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. System 5 is a trademark of Bell Labs, Incorporated. BSD4.3 is a trademark of the University of California at Berkeley. UNIX is a registered trademark of AT&T.

PLOT3D/AMES, GENERIC UNIX VERSION USING DISSPLA (WITHOUT TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The UNIX/DISSPLA implementation of PLOT3D supports 2-D polygons as well as 2-D and 3-D lines, but does not support graphics features requiring 3-D polygons (shading and hidden line removal, for example). Views can be manipulated using keyboard commands. This version of PLOT3D is potentially able to produce files for a variety of output devices; however, site-specific capabilities will vary depending on the device drivers supplied with the user's DISSPLA library. The version 3.6b+ UNIX/DISSPLA implementations of PLOT3D (ARC-12788) and PLOT3D/TURB3D (ARC-12778) were developed for use on computers running UNIX SYSTEM 5 with BSD 4.3 extensions. The standard distribution media for each ofthese programs is a 9track, 6250 bpi magnetic tape in TAR format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D (ARC-12783, ARC-12782); (3) VAX computers running VMS Version 5.0 and DISSPLA Version 11.0 (ARC-12777, ARC-12781); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. System 5 is a trademark of Bell Labs, Incorporated. BSD4.3 is a trademark of the University of California at Berkeley. UNIX is a registered trademark of AT&T.

Esophageal motor function in Graves' disease.

PubMed

Meshkinpour, H; Afrasiabi, M A; Valenta, L J

1979-02-01

Esophageal motor function was studied in 10 patients with untreated Graves' disease and 15 healthy volunteers who served as controls. A noncompliant recording system with a triple-lumen assembly was used. Resting upper- and lower-esophageal-sphincter pressures, amplitude, duration, and velocity of peristaltic contractions in the body of the esophagus, and the number of repetitive and simultaneous contractions were measured. There was no significant difference in peristaltic amplitude and duration between the controls and the patients with Graves' disease. However, there was a significant increase in velocity of contractions in Graves' disease as compared with controls. On restudy of 5 patients who became euthyroid after treatment with 131I, all the measured parameters were unchanged except for velocity of the peristaltic contractions. The value for this measurement decreased essentially to the same as that found in the control subjects. It is concluded that: (1) thyrotoxicosis increases the propagation velocity of esophageal contraction, and (2) thyroid hormones may play a physiologic role in the control of esophageal motor function.

48 CFR 42.603 - Responsibilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Responsibilities. (a) The CACO shall perform, on a corporate-wide basis, the contract administration functions as designated by the responsible agency. Typical CACO functions include (1) the determination of final indirect cost rates for cost-reimbursement contracts, (2) establishment of advance agreements or recommendations...

48 CFR 742.1170-1 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 742.1170-1 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT CONTRACT ADMINISTRATION Production, Surveillance, and Reporting 742.1170-1 General. Performance monitoring is a function of contract administration used to determine contractor progress towards achieving...

48 CFR 42.601 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

....601 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT CONTRACT... more than one operational location (e.g., division, plant, or subsidiary) often have corporate-wide... officer (CACO) to deal with corporate management and to perform selected contract administration functions...

Decreased contraction induced by endothelium-derived contracting factor in prolonged treatment of rat renal artery with endoplasmic reticulum stress inducer.

PubMed

Ando, Makoto; Matsumoto, Takayuki; Taguchi, Kumiko; Kobayashi, Tsuneo

2018-05-04

Recent evidence suggests that endoplasmic reticulum (ER) stress is involved in the regulation of various physiological functions, including those of the vascular system. However, the relationship between ER stress and vascular function is poorly understood. The endothelial cells control the vascular tone by releasing endothelium-derived relaxing factors and contracting factors (EDCFs). We hypothesized that tunicamycin, an inducer of ER stress, modifies endothelium-dependent contraction and prostaglandins (PGs), a major class of EDCFs, induced contractions in the rat renal artery in rats. An organ-culture technique was used to purely investigate the effects of ER stress on the vascular tissue. We observed that tunicamycin treatment (20 μg/mL for 23 ± 1 h) did not affect acetylcholine (ACh)-induced relaxation and decreased EDCF-mediated contractions under nitric oxide synthase (NOS) inhibition induced by ACh, ATP, or A23187 (a calcium ionophore) in the renal arteries. Under NOS inhibition, U46619 (a thromboxane A 2 mimetic)- and beraprost (a prostacyclin analog)-induced contractions were also decreased in the renal arteries of the tunicamycin-treated group (vs. vehicle), while PGE 2 - and PGF 2α -induced contractions were similar between the groups. Tunicamycin treatment slightly enhanced the contractions induced by phenylephrine, an α 1 adrenoceptor ligand. Isotonic high-K + -induced contractions were similar between the vehicle- and tunicamycin-treated groups. Another ER stress inducer, thapsigargin (4 μmol/L for 23 ± 1 h), also caused substantial reduction of ACh-induced EDCF-mediated contraction (vs. vehicle-treated group). In the cultured renal arteries, tunicamycin and thapsigargin increased the expression of binding immunoglobulin protein (BiP), an ER stress marker. In conclusion, ER stress induction directly affects renal arterial function, especially in reducing EDCF-mediated contractions.

Graphical Representation and Origin of Piezoresistance Effect in Germanium

NASA Astrophysics Data System (ADS)

Matsuda, K.; Nagaoka, S.; Kanda, Y.

2017-06-01

The longitudinal and transverse piezoresistance coefficients of Ge at room temperature are represented graphically as a function of the crystal directions for orientation (001), (110) and (211) planes. Many valley model of conduction band and stress decoupling decoupling of the degenerate valence band into two bands of prolate and oblate ellipsoidal energy surface are shown to explain origin of the piezoresistance. One this basis, comparison between piezoresistance coefficient and theoretical model is discussed.

SutraPlot, a graphical post-processor for SUTRA, a model for ground-water flow with solute or energy transport

USGS Publications Warehouse

Souza, W.R.

1999-01-01

This report documents a graphical display post-processor (SutraPlot) for the U.S. Geological Survey Saturated-Unsaturated flow and solute or energy TRAnsport simulation model SUTRA, Version 2D3D.1. This version of SutraPlot is an upgrade to SutraPlot for the 2D-only SUTRA model (Souza, 1987). It has been modified to add 3D functionality, a graphical user interface (GUI), and enhanced graphic output options. Graphical options for 2D SUTRA (2-dimension) simulations include: drawing the 2D finite-element mesh, mesh boundary, and velocity vectors; plots of contours for pressure, saturation, concentration, and temperature within the model region; 2D finite-element based gridding and interpolation; and 2D gridded data export files. Graphical options for 3D SUTRA (3-dimension) simulations include: drawing the 3D finite-element mesh; plots of contours for pressure, saturation, concentration, and temperature in 2D sections of the 3D model region; 3D finite-element based gridding and interpolation; drawing selected regions of velocity vectors (projected on principal coordinate planes); and 3D gridded data export files. Installation instructions and a description of all graphic options are presented. A sample SUTRA problem is described and three step-by-step SutraPlot applications are provided. In addition, the methodology and numerical algorithms for the 2D and 3D finite-element based gridding and interpolation, developed for SutraPlot, are described. 1

Functional difference in short- and long-latency interhemispheric inhibitions from active to resting hemisphere during a unilateral muscle contraction.

PubMed

Uehara, Kazumasa; Morishita, Takuya; Kubota, Shinji; Hirano, Masato; Funase, Kozo

2014-01-01

The aim of the present study was to investigate whether there is a functional difference in short-latency (SIHI) and long-latency (LIHI) interhemispheric inhibition from the active to the resting primary motor cortex (M1) with paired-pulse transcranial magnetic stimulation during a unilateral muscle contraction. In nine healthy right-handed participants, IHI was tested from the dominant to the nondominant M1 and vice versa under resting conditions or during performance of a sustained unilateral muscle contraction with the right or left first dorsal interosseous muscle at 10% and 30% maximum voluntary contraction. To obtain measurements of SIHI and LIHI, a conditioning stimulus (CS) was applied over the M1 contralateral to the muscle contraction, followed by a test stimulus over the M1 ipsilateral to the muscle contraction at short (10 ms) and long (40 ms) interstimulus intervals. We used four CS intensities to investigate SIHI and LIHI from the active to the resting M1 systematically. The amount of IHI during the unilateral muscle contractions showed a significant difference between SIHI and LIHI, but the amount of IHI during the resting condition did not. In particular, SIHI during the muscle contractions, but not LIHI, significantly increased with increase in CS intensity compared with the resting condition. Laterality of IHI was not detected in any of the experimental conditions. The present study provides novel evidence that a functional difference between SIHI and LIHI from the active to the resting M1 exists during unilateral muscle contractions.

77 FR 10577 - International Mail Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-22

...-filed Postal Service request to enter into an additional International Business Reply Service contract... additional International Business Reply Service (IBRS) contract.\\1\\ The Postal Service asserts that the... United States Postal Service Filing of a Functionally Equivalent International Business Reply Service...

Government - contractor interaction

NASA Technical Reports Server (NTRS)

Thomas, D. M.

1983-01-01

The development of the Administrative Contracting Officer represents an advance in the Government system of contract management because it provides an individual with knowledge, time, and a specialized function to insure performance of Government contracts. However, the development has created a dichotomy between the award and the post-award function which increases the adversary relationship with Government contractors. This paper advocates that this adversary relationship can be decreased if PCOs and ACOs are provided with opportunities to serve in the assignments of the other.

PLOT3D/AMES, DEC VAX VMS VERSION USING DISSPLA (WITHOUT TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P. G.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The VAX/VMS/DISSPLA implementation of PLOT3D supports 2-D polygons as well as 2-D and 3-D lines, but does not support graphics features requiring 3-D polygons (shading and hidden line removal, for example). Views can be manipulated using keyboard commands. This version of PLOT3D is potentially able to produce files for a variety of output devices; however, site-specific capabilities will vary depending on the device drivers supplied with the user's DISSPLA library. If ARCGRAPH (ARC-12350) is installed on the user's VAX, the VMS/DISSPLA version of PLOT3D can also be used to create files for use in GAS (Graphics Animation System, ARC-12379), an IRIS program capable of animating and recording images on film. The version 3.6b+ VMS/DISSPLA implementations of PLOT3D (ARC-12777) and PLOT3D/TURB3D (ARC-12781) were developed for use on VAX computers running VMS Version 5.0 and DISSPLA Version 11.0. The standard distribution media for each of these programs is a 9-track, 6250 bpi magnetic tape in DEC VAX BACKUP format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D (ARC-12783, ARC12782); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

PLOT3D/AMES, DEC VAX VMS VERSION USING DISSPLA (WITH TURB3D)

NASA Technical Reports Server (NTRS)

Buning, P.

1994-01-01

PLOT3D is an interactive graphics program designed to help scientists visualize computational fluid dynamics (CFD) grids and solutions. Today, supercomputers and CFD algorithms can provide scientists with simulations of such highly complex phenomena that obtaining an understanding of the simulations has become a major problem. Tools which help the scientist visualize the simulations can be of tremendous aid. PLOT3D/AMES offers more functions and features, and has been adapted for more types of computers than any other CFD graphics program. Version 3.6b+ is supported for five computers and graphic libraries. Using PLOT3D, CFD physicists can view their computational models from any angle, observing the physics of problems and the quality of solutions. As an aid in designing aircraft, for example, PLOT3D's interactive computer graphics can show vortices, temperature, reverse flow, pressure, and dozens of other characteristics of air flow during flight. As critical areas become obvious, they can easily be studied more closely using a finer grid. PLOT3D is part of a computational fluid dynamics software cycle. First, a program such as 3DGRAPE (ARC-12620) helps the scientist generate computational grids to model an object and its surrounding space. Once the grids have been designed and parameters such as the angle of attack, Mach number, and Reynolds number have been specified, a "flow-solver" program such as INS3D (ARC-11794 or COS-10019) solves the system of equations governing fluid flow, usually on a supercomputer. Grids sometimes have as many as two million points, and the "flow-solver" produces a solution file which contains density, x- y- and z-momentum, and stagnation energy for each grid point. With such a solution file and a grid file containing up to 50 grids as input, PLOT3D can calculate and graphically display any one of 74 functions, including shock waves, surface pressure, velocity vectors, and particle traces. PLOT3D's 74 functions are organized into five groups: 1) Grid Functions for grids, grid-checking, etc.; 2) Scalar Functions for contour or carpet plots of density, pressure, temperature, Mach number, vorticity magnitude, helicity, etc.; 3) Vector Functions for vector plots of velocity, vorticity, momentum, and density gradient, etc.; 4) Particle Trace Functions for rake-like plots of particle flow or vortex lines; and 5) Shock locations based on pressure gradient. TURB3D is a modification of PLOT3D which is used for viewing CFD simulations of incompressible turbulent flow. Input flow data consists of pressure, velocity and vorticity. Typical quantities to plot include local fluctuations in flow quantities and turbulent production terms, plotted in physical or wall units. PLOT3D/TURB3D includes both TURB3D and PLOT3D because the operation of TURB3D is identical to PLOT3D, and there is no additional sample data or printed documentation for TURB3D. Graphical capabilities of PLOT3D version 3.6b+ vary among the implementations available through COSMIC. Customers are encouraged to purchase and carefully review the PLOT3D manual before ordering the program for a specific computer and graphics library. There is only one manual for use with all implementations of PLOT3D, and although this manual generally assumes that the Silicon Graphics Iris implementation is being used, informative comments concerning other implementations appear throughout the text. With all implementations, the visual representation of the object and flow field created by PLOT3D consists of points, lines, and polygons. Points can be represented with dots or symbols, color can be used to denote data values, and perspective is used to show depth. Differences among implementations impact the program's ability to use graphical features that are based on 3D polygons, the user's ability to manipulate the graphical displays, and the user's ability to obtain alternate forms of output. The VAX/VMS/DISSPLA implementation of PLOT3D supports 2-D polygons as well as 2-D and 3-D lines, but does not support graphics features requiring 3-D polygons (shading and hidden line removal, for example). Views can be manipulated using keyboard commands. This version of PLOT3D is potentially able to produce files for a variety of output devices; however, site-specific capabilities will vary depending on the device drivers supplied with the user's DISSPLA library. If ARCGRAPH (ARC-12350) is installed on the user's VAX, the VMS/DISSPLA version of PLOT3D can also be used to create files for use in GAS (Graphics Animation System, ARC-12379), an IRIS program capable of animating and recording images on film. The version 3.6b+ VMS/DISSPLA implementations of PLOT3D (ARC-12777) and PLOT3D/TURB3D (ARC-12781) were developed for use on VAX computers running VMS Version 5.0 and DISSPLA Version 11.0. The standard distribution media for each of these programs is a 9-track, 6250 bpi magnetic tape in DEC VAX BACKUP format. Customers purchasing one implementation version of PLOT3D or PLOT3D/TURB3D will be given a $200 discount on each additional implementation version ordered at the same time. Version 3.6b+ of PLOT3D and PLOT3D/TURB3D are also supported for the following computers and graphics libraries: (1) generic UNIX Supercomputer and IRIS, suitable for CRAY 2/UNICOS, CONVEX, and Alliant with remote IRIS 2xxx/3xxx or IRIS 4D (ARC-12779, ARC-12784); (2) Silicon Graphics IRIS 2xxx/3xxx or IRIS 4D (ARC-12783, ARC12782); (3) generic UNIX and DISSPLA Version 11.0 (ARC-12788, ARC-12778); and (4) Apollo computers running UNIX and GMR3D Version 2.0 (ARC-12789, ARC-12785 which have no capabilities to put text on plots). Silicon Graphics Iris, IRIS 4D, and IRIS 2xxx/3xxx are trademarks of Silicon Graphics Incorporated. VAX and VMS are trademarks of Digital Electronics Corporation. DISSPLA is a trademark of Computer Associates. CRAY 2 and UNICOS are trademarks of CRAY Research, Incorporated. CONVEX is a trademark of Convex Computer Corporation. Alliant is a trademark of Alliant. Apollo and GMR3D are trademarks of Hewlett-Packard, Incorporated. UNIX is a registered trademark of AT&T.

Impact of Business Cycles on US Suicide Rates, 1928–2007

PubMed Central

Florence, Curtis S.; Quispe-Agnoli, Myriam; Ouyang, Lijing; Crosby, Alexander E.

2011-01-01

Objectives. We examined the associations of overall and age-specific suicide rates with business cycles from 1928 to 2007 in the United States. Methods. We conducted a graphical analysis of changes in suicide rates during business cycles, used nonparametric analyses to test associations between business cycles and suicide rates, and calculated correlations between the national unemployment rate and suicide rates. Results. Graphical analyses showed that the overall suicide rate generally rose during recessions and fell during expansions. Age-specific suicide rates responded differently to recessions and expansions. Nonparametric tests indicated that the overall suicide rate and the suicide rates of the groups aged 25 to 34 years, 35 to 44 years, 45 to 54 years, and 55 to 64 years rose during contractions and fell during expansions. Suicide rates of the groups aged 15 to 24 years, 65 to 74 years, and 75 years and older did not exhibit this behavior. Correlation results were concordant with all nonparametric results except for the group aged 65 to 74 years. Conclusions. Business cycles may affect suicide rates, although different age groups responded differently. Our findings suggest that public health responses are a necessary component of suicide prevention during recessions. PMID:21493938

Hemodynamics of a functional centrifugal-flow total artificial heart with functional atrial contraction in goats.

PubMed

Shiga, Takuya; Shiraishi, Yasuyuki; Sano, Kyosuke; Taira, Yasunori; Tsuboko, Yusuke; Yamada, Akihiro; Miura, Hidekazu; Katahira, Shintaro; Akiyama, Masatoshi; Saiki, Yoshikatsu; Yambe, Tomoyuki

2016-03-01

Implantation of a total artificial heart (TAH) is one of the therapeutic options for the treatment of patients with end-stage biventricular heart failure. There is no report on the hemodynamics of the functional centrifugal-flow TAH with functional atrial contraction (fCFTAH). We evaluated the effects of pulsatile flow by atrial contraction in acute animal models. The goats received fCFTAH that we created from two centrifugal-flow ventricular assist devices. Some hemodynamic parameters maintained acceptable levels: heart rate 115.5 ± 26.3 bpm, aortic pressure 83.5 ± 10.1 mmHg, left atrial pressure 18.0 ± 5.9 mmHg, pulmonary pressure 28.5 ± 9.7 mmHg, right atrial pressure 13.6 ± 5.2 mmHg, pump flow 4.0 ± 1.1 L/min (left) 3.9 ± 1.1 L/min (right), and cardiac index 2.13 ± 0.14 L/min/m(2). fCFTAH with atrial contraction was able to maintain the TAH circulation by forming a pulsatile flow in acute animal experiments. Taking the left and right flow rate balance using the low internal pressure loss of the VAD pumps may be easier than by other pumps having considerable internal pressure loss. We showed that the remnant atrial contraction effected the flow rate change of the centrifugal pump, and the atrial contraction waves reflected the heart rate. These results indicate that remnant atria had the possibility to preserve autonomic function in fCFTAH. We may control fCFTAH by reflecting the autonomic function, which is estimated with the flow rate change of the centrifugal pump.

Effects of hypothyroidism on the skeletal muscle blood flow response to contractions.

PubMed

Bausch, L; McAllister, R M

2003-04-01

Hypothyroidism is associated with impaired blood flow to skeletal muscle under whole body exercise conditions. It is unclear whether poor cardiac and/or vascular function account for blunted muscle blood flow. Our experiment isolated a small group of hindlimb muscles and simulated exercise via tetanic contractions. We hypothesized that muscle blood flow would be attenuated in hypothyroid rats (HYPO) compared with euthyroid rats (EUT). Rats were made hypothyroid by mixing propylthiouracil in their drinking water (2.35 x 10-3 mol/l). Treatment efficacy was evidenced by lower serum T3 concentrations and resting heart rates in HYPO (both P<0.05). In the experimental preparation, isometric contractions of the lower right hindlimb muscles at a rate of 30 tetani/min were induced via sciatic nerve stimulation. Regional blood flows were determined by the radiolabelled microsphere method at three time points: rest, 2 min of contractions and 10 min of contractions. Muscle blood flow generally increased from rest ( approximately 5-10 ml/min per 100 g) through contractions for both groups. Further, blood flow during contractions did not differ between groups for any muscle (eg. red section of gastrocnemius muscle; EUT, 59.9 +/- 14.1; HYPO, 61.1 +/- 15.0; NS between groups). These findings indicate that hypothyroidism does not significantly impair skeletal muscle blood flow when only a small muscle mass is contracting. Our findings suggest that impaired blood flow under whole body exercise is accounted for by inadequate cardiac function rather than abnormal vascular function.

Inequalities, Signum Functions and Wrinkles in Wiggle Graphs.

ERIC Educational Resources Information Center

Priest, Dean B.; Wood, Dianne

Presented is a graphical approach to teaching higher degree, rational function, and absolute value inequalities that simplifies the solution of these inequalities and thereby reduces the amount of classroom time that has to be devoted to this topic. Applications are also given for signum functions, maximum-minimum, and points of inflection…

Helping Students-Connect Functions and Their Representations

ERIC Educational Resources Information Center

Moore-Russo, Deborah; Golzy, John B.

2005-01-01

The description about the changed instruction to encourage student exploration of the graphical and then the algebraic representations of functions is presented, which enables the students to understand how the graph, equation, and table of a function are related. The activity addresses both the Learning Principle and the Connection standard and…

A Qualitative Approach to Sketch the Graph of a Function.

ERIC Educational Resources Information Center

Alson, Pedro

1992-01-01

Presents a qualitative and global method of graphing functions that involves transformations of the graph of a known function in the cartesian coordinate system referred to as graphic operators. Explains how the method has been taught to students and some comments about the results obtained. (MDH)

What are the origins and relevance of spontaneous bladder contractions? ICI-RS 2017.

PubMed

Drake, Marcus J; Fry, Christopher H; Hashitani, Hikaru; Kirschner-Hermanns, Ruth; Rahnama'i, Mohammad S; Speich, John E; Tomoe, Hikaru; Kanai, Anthony J; McCloskey, Karen D

2018-01-23

Storage phase bladder activity is a counter-intuitive observation of spontaneous contractions. They are potentially an intrinsic feature of the smooth muscle, but interstitial cells in the mucosa and the detrusor itself, as well as other muscular elements in the mucosa may substantially influence them. They are identified in several models explaining lower urinary tract dysfunction. A consensus meeting at the International Consultation on Incontinence Research Society (ICI-RS) 2017 congress considered the origins and relevance of spontaneous bladder contractions by debating which cell type(s) modulate bladder spontaneous activity, whether the methodologies are sufficiently robust, and implications for healthy and abnormal lower urinary tract function. The identified research priorities reflect a wide range of unknown aspects. Cellular contributions to spontaneous contractions in detrusor smooth muscle are still uncertain. Accordingly, insight into the cellular physiology of the bladder wall, particularly smooth muscle cells, interstitial cells, and urothelium, remains important. Upstream influences, such as innervation, endocrine, and paracrine factors, are particularly important. The cellular interactions represent the key understanding to derive the integrative physiology of organ function, notably the nature of signalling between mucosa and detrusor layers. Indeed, it is still not clear to what extent spontaneous contractions generated in isolated preparations mirror their normal and pathological counterparts in the intact bladder. Improved models of how spontaneous contractions influence pressure generation and sensory nerve function are also needed. Deriving approaches to robust evaluation of spontaneous contractions and their influences for experimental and clinical use could yield considerable progress in functional urology. © 2018 Wiley Periodicals, Inc.

Use of a graphics processing unit (GPU) to facilitate real-time 3D graphic presentation of the patient skin-dose distribution during fluoroscopic interventional procedures

PubMed Central

Rana, Vijay; Rudin, Stephen; Bednarek, Daniel R.

2012-01-01

We have developed a dose-tracking system (DTS) that calculates the radiation dose to the patient’s skin in real-time by acquiring exposure parameters and imaging-system-geometry from the digital bus on a Toshiba Infinix C-arm unit. The cumulative dose values are then displayed as a color map on an OpenGL-based 3D graphic of the patient for immediate feedback to the interventionalist. Determination of those elements on the surface of the patient 3D-graphic that intersect the beam and calculation of the dose for these elements in real time demands fast computation. Reducing the size of the elements results in more computation load on the computer processor and therefore a tradeoff occurs between the resolution of the patient graphic and the real-time performance of the DTS. The speed of the DTS for calculating dose to the skin is limited by the central processing unit (CPU) and can be improved by using the parallel processing power of a graphics processing unit (GPU). Here, we compare the performance speed of GPU-based DTS software to that of the current CPU-based software as a function of the resolution of the patient graphics. Results show a tremendous improvement in speed using the GPU. While an increase in the spatial resolution of the patient graphics resulted in slowing down the computational speed of the DTS on the CPU, the speed of the GPU-based DTS was hardly affected. This GPU-based DTS can be a powerful tool for providing accurate, real-time feedback about patient skin-dose to physicians while performing interventional procedures. PMID:24027616

Use of a graphics processing unit (GPU) to facilitate real-time 3D graphic presentation of the patient skin-dose distribution during fluoroscopic interventional procedures.

PubMed

Rana, Vijay; Rudin, Stephen; Bednarek, Daniel R

2012-02-23

We have developed a dose-tracking system (DTS) that calculates the radiation dose to the patient's skin in real-time by acquiring exposure parameters and imaging-system-geometry from the digital bus on a Toshiba Infinix C-arm unit. The cumulative dose values are then displayed as a color map on an OpenGL-based 3D graphic of the patient for immediate feedback to the interventionalist. Determination of those elements on the surface of the patient 3D-graphic that intersect the beam and calculation of the dose for these elements in real time demands fast computation. Reducing the size of the elements results in more computation load on the computer processor and therefore a tradeoff occurs between the resolution of the patient graphic and the real-time performance of the DTS. The speed of the DTS for calculating dose to the skin is limited by the central processing unit (CPU) and can be improved by using the parallel processing power of a graphics processing unit (GPU). Here, we compare the performance speed of GPU-based DTS software to that of the current CPU-based software as a function of the resolution of the patient graphics. Results show a tremendous improvement in speed using the GPU. While an increase in the spatial resolution of the patient graphics resulted in slowing down the computational speed of the DTS on the CPU, the speed of the GPU-based DTS was hardly affected. This GPU-based DTS can be a powerful tool for providing accurate, real-time feedback about patient skin-dose to physicians while performing interventional procedures.

Organization and Functions: Field Operating Agencies of The Judge Advocate General

DTIC Science & Technology

1989-03-20

Criminal Investi- gation Command. (6) Army Military Command Contract Law Specialist Training Program, which trains officers in providing legal advice and...opera- tions in the functional areas of contract law . (7) Patents, Copyrights, and Trademarks Division, which— (a) Manages the administration, control

45 CFR 5b.2 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PRIVACY ACT REGULATIONS § 5b.2... Federal functions, such as intermediaries and carriers performing functions under contracts and agreements... year) or intermittent services have been procured by the Department by contract pursuant to 3109 of...

The development of a computer-assisted instruction system for clinical nursing skills with virtual instruments concepts: A case study for intra-aortic balloon pumping.

PubMed

Chang, Ching-I; Yan, Huey-Yeu; Sung, Wen-Hsu; Shen, Shu-Cheng; Chuang, Pao-Yu

2006-01-01

The purpose of this research was to develop a computer-aided instruction system for intra-aortic balloon pumping (IABP) skills in clinical nursing with virtual instrument (VI) concepts. Computer graphic technologies were incorporated to provide not only static clinical nursing education, but also the simulated function of operating an expensive medical instrument with VI techniques. The content of nursing knowledge was adapted from current well-accepted clinical training materials. The VI functions were developed using computer graphic technology with photos of real medical instruments taken by digital camera. We wish the system could provide beginners of nursing education important teaching assistance.

48 CFR 736.602-3 - Evaluation board functions.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... 736.602-3 Section 736.602-3 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer... of the contracting activity for his/her approval. This selection memorandum shall include the...

48 CFR 736.602-3 - Evaluation board functions.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... 736.602-3 Section 736.602-3 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer... of the contracting activity for his/her approval. This selection memorandum shall include the...

Atlas/Data Abstract for the United States and Selected Areas: Fiscal Year 1988

DTIC Science & Technology

1988-01-01

more than one plant, the contract has been attributed to the location where the largest dollar amount of work will be performed. Both construction and...67,322 170,367 44,068 123 Service Contracts 596,632 82,939 430,629 71,587 11,477 Construction Contracts 14,788 163 14,625 0 0 Civil Function Contracts...Contracts 151,308 16,972 7,680 5,040 121,616 R&D Contracts 15,559 8,513 2,997 4,049 0 Service Contracts 50,458 2,246 28,987 17,214 2,011 Construction

Wavelet Decomposition for Discrete Probability Maps

DTIC Science & Technology

2007-08-01

using other wavelet basis functions, such as those mentioned in Section 7 15 DSTO–TN–0760 References 1. P. M. Bentley and J . T . E. McDonnell. Wavelet...84, 1995. 0272-1716. 18. E. J . Stollnitz, T . D. DeRose, and D. H. Salesin. Wavelets for computer graphics: a primer. 2. Computer Graphics and...and Computer Modelling in 2006 from the University of South Australia, Mawson Lakes. Part of this de- gree was undertaken at the University of Twente

Software For Graphical Representation Of A Network

NASA Technical Reports Server (NTRS)

Mcallister, R. William; Mclellan, James P.

1993-01-01

System Visualization Tool (SVT) computer program developed to provide systems engineers with means of graphically representing networks. Generates diagrams illustrating structures and states of networks defined by users. Provides systems engineers powerful tool simplifing analysis of requirements and testing and maintenance of complex software-controlled systems. Employs visual models supporting analysis of chronological sequences of requirements, simulation data, and related software functions. Applied to pneumatic, hydraulic, and propellant-distribution networks. Used to define and view arbitrary configurations of such major hardware components of system as propellant tanks, valves, propellant lines, and engines. Also graphically displays status of each component. Advantage of SVT: utilizes visual cues to represent configuration of each component within network. Written in Turbo Pascal(R), version 5.0.

FDA cigarette warning labels lower craving and elicit frontoinsular activation in adolescent smokers

PubMed Central

Do, Kathy T.

2015-01-01

Cigarette smoking is an economically and epidemiologically expensive public health concern. Most adult smokers become addicted during adolescence, rendering it a crucial period for prevention and intervention. Although litigation claims have delayed implementation, graphic warning labels proposed by the U.S. Food and Drug Administration (FDA) may be a promising way to achieve this goal. We aimed to determine the efficacy of the labels in reducing in-scanner craving and to characterize the neurobiological responses in adolescent and adult smokers and non-smokers. While undergoing functional magnetic resonance imaging, thirty-nine 13- to 18-year-old adolescent and forty-one 25- to 30-year-old adult smokers and non-smokers rated their desire to smoke when presented with emotionally graphic warning labels and comparison non-graphic labels. Compared with adult smokers, adolescent smokers exhibited greater craving reduction in response to the warning labels. Although smokers evinced overall blunted recruitment of insula and dorsolateral prefrontal cortex (DLPFC) relative to non-smokers, an effect that was stronger in adolescent smokers, parametrically increasing activation of these regions was associated with greater craving reduction. Functional connectivity analyses suggest that greater DLPFC regulation of limbic regions predicted cigarette craving. These data underscore a prominent role of frontoinsular circuitry in predicting the efficacy of FDA graphic warning labels in craving reduction in adult and adolescent smokers. PMID:25887154

The Development of a Myoelectric Training Tool for Above-Elbow Amputees

PubMed Central

Dawson, Michael R; Fahimi, Farbod; Carey, Jason P

2012-01-01

The objective of above-elbow myoelectric prostheses is to reestablish the functionality of missing limbs and increase the quality of life of amputees. By using electromyography (EMG) electrodes attached to the surface of the skin, amputees are able to control motors in myoelectric prostheses by voluntarily contracting the muscles of their residual limb. This work describes the development of an inexpensive myoelectric training tool (MTT) designed to help upper limb amputees learn how to use myoelectric technology in advance of receiving their actual myoelectric prosthesis. The training tool consists of a physical and simulated robotic arm, signal acquisition hardware, controller software, and a graphical user interface. The MTT improves over earlier training systems by allowing a targeted muscle reinnervation (TMR) patient to control up to two degrees of freedom simultaneously. The training tool has also been designed to function as a research prototype for novel myoelectric controllers. A preliminary experiment was performed in order to evaluate the effectiveness of the MTT as a learning tool and to identify any issues with the system. Five able-bodied participants performed a motor-learning task using the EMG controlled robotic arm with the goal of moving five balls from one box to another as quickly as possible. The results indicate that the subjects improved their skill in myoelectric control over the course of the trials. A usability survey was administered to the subjects after their trials. Results from the survey showed that the shoulder degree of freedom was the most difficult to control. PMID:22383905

The development of a myoelectric training tool for above-elbow amputees.

PubMed

Dawson, Michael R; Fahimi, Farbod; Carey, Jason P

2012-01-01

The objective of above-elbow myoelectric prostheses is to reestablish the functionality of missing limbs and increase the quality of life of amputees. By using electromyography (EMG) electrodes attached to the surface of the skin, amputees are able to control motors in myoelectric prostheses by voluntarily contracting the muscles of their residual limb. This work describes the development of an inexpensive myoelectric training tool (MTT) designed to help upper limb amputees learn how to use myoelectric technology in advance of receiving their actual myoelectric prosthesis. The training tool consists of a physical and simulated robotic arm, signal acquisition hardware, controller software, and a graphical user interface. The MTT improves over earlier training systems by allowing a targeted muscle reinnervation (TMR) patient to control up to two degrees of freedom simultaneously. The training tool has also been designed to function as a research prototype for novel myoelectric controllers. A preliminary experiment was performed in order to evaluate the effectiveness of the MTT as a learning tool and to identify any issues with the system. Five able-bodied participants performed a motor-learning task using the EMG controlled robotic arm with the goal of moving five balls from one box to another as quickly as possible. The results indicate that the subjects improved their skill in myoelectric control over the course of the trials. A usability survey was administered to the subjects after their trials. Results from the survey showed that the shoulder degree of freedom was the most difficult to control.

PROGRAPH Diagrams--A New Old System for Teaching Functional Modelling

ERIC Educational Resources Information Center

Siller, Hans-Stefan

2009-01-01

This paper shows the basic concept of Functional Modelling in mathematics education which has become more and more important in recent years. Hence it is necessary to think about suitable graphical methods to explain the fundamental idea of a function and its influence on values and other functions. PROGRAPH diagrams are a potentially good way to…

Graphical representation of robot grasping quality measures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Varma, V.; Tasch, U.

1993-11-01

When an object is held by a multi-fingered hand, the values of the contact forces can be multivalued. An objective function, when used in conjunction with the frictional and geometric constraints of the grasp, can however, give a unique set of finger force values. The selection of the objective function in determining the finger forces is dependent on the type of grasp required, the material properties of the object, and the limitations of the robot fingers. In this paper several optimization functions are studied and their merits highlighted. A graphical representation of the finger force values and the objective functionmore » is introduced that enable one in selecting and comparing various grasping configurations. The impending motion of the object at different torque and finger force values are determined by observing the normalized coefficient of friction plots.« less

Multidimensional stochastic approximation using locally contractive functions

NASA Technical Reports Server (NTRS)

Lawton, W. M.

1975-01-01

A Robbins-Monro type multidimensional stochastic approximation algorithm which converges in mean square and with probability one to the fixed point of a locally contractive regression function is developed. The algorithm is applied to obtain maximum likelihood estimates of the parameters for a mixture of multivariate normal distributions.

75 FR 72845 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-26

... contract for future functional equivalence analyses of the GEPS 3 product. \\1\\ Notice of United States... analysis of the formulas, and certification of the Governors' vote; and Attachment 4--an application for... costing information and volume commitments, do not alter the contracts' functional equivalency. Id. at 3-4...

Examining Functions in Mathematics and Science Using Computer Interfacing.

ERIC Educational Resources Information Center

Walton, Karen Doyle

1988-01-01

Introduces microcomputer interfacing as a method for explaining and demonstrating various aspects of the concept of function. Provides three experiments with illustrations and typical computer graphic displays: pendulum motion, pendulum study using two pendulums, and heat absorption and radiation. (YP)

Application of the AMBUR R package for spatio-temporal analysis of shoreline change: Jekyll Island, Georgia, USA

NASA Astrophysics Data System (ADS)

Jackson, Chester W.; Alexander, Clark R.; Bush, David M.

2012-04-01

The AMBUR (Analyzing Moving Boundaries Using R) package for the R software environment provides a collection of functions for assisting with analyzing and visualizing historical shoreline change. The package allows import and export of geospatial data in ESRI shapefile format, which is compatible with most commercial and open-source GIS software. The "baseline and transect" method is the primary technique used to quantify distances and rates of shoreline movement, and to detect classification changes across time. Along with the traditional "perpendicular" transect method, two new transect methods, "near" and "filtered," assist with quantifying changes along curved shorelines that are problematic for perpendicular transect methods. Output from the analyses includes data tables, graphics, and geospatial data, which are useful in rapidly assessing trends and potential errors in the dataset. A forecasting function also allows the user to estimate the future location of the shoreline and store the results in a shapefile. Other utilities and tools provided in the package assist with preparing and manipulating geospatial data, error checking, and generating supporting graphics and shapefiles. The package can be customized to perform additional statistical, graphical, and geospatial functions, and, it is capable of analyzing the movement of any boundary (e.g., shorelines, glacier terminus, fire edge, and marine and terrestrial ecozones).

Graphical method for determining the coefficient of consolidation cv from a flow-pump permeability test

USGS Publications Warehouse

Morin, Roger H.; Olsen, Harold W.; Nelson, Karl R.; Gill, James D.

1989-01-01

A graphical method has been developed for determining the coefficient of consolidation from the transient phases of a flow-pump permeability test. The flow pump can be used to infuse fluid into or withdraw fluid from a laboratory sediment specimen at a constant volumetric rate in order to obtain data that can be used to calculate permeability using Darcy's law. Representative type-curve solutions to the associated forced-flow and pressure-decay models are derived. These curves provide the basis for graphically evaluating the permeability k, the coefficient of consolidation cv, and the coefficient of volume change mv. The curve-matching technique is easy and rapid. Values of k, cv and mv for a laterally confined kaolinite specimen were determined by this graphical method and appear to be in reasonably good agreement with numerically derived estimates (within 20%). Discrepancies between the two sets of results seem to be largely a function of data quality.

Trigeminal Proprioception Evoked by Strong Stretching of the Mechanoreceptors in Müller's Muscle Induces Reflex Contraction of the Orbital Orbicularis Oculi Slow-Twitch Muscle Fibers.

PubMed

Matsuo, Kiyoshi; Ban, Ryokuya; Ban, Midori; Yuzuriha, Shunsuke

2014-01-01

The mixed orbicularis oculi muscle lacks an intramuscular proprioceptive system such as muscle spindles, to induce reflex contraction of its slow-twitch fibers. We evaluated whether the mechanoreceptors in Müller's muscle function as extrinsic mechanoreceptors to induce reflex contraction of the slow-twitch fibers of the orbicularis oculi in addition to those of the levator and frontalis muscles. We evaluated in patients with aponeurosis-disinserted blepharoptosis whether strong stretching of the mechanoreceptors in Müller's muscle from upgaze with unilateral lid load induced reflex contraction of the orbicularis oculi slow-twitch fibers and whether anesthesia of Müller's muscle precluded the contraction. We compared the electromyographic responses of the bilateral orbicularis oculi muscles to unilateral intraoperative direct stimulation of the trigeminal proprioceptive nerve with those to unilateral transcutaneous electrical stimulation of the supraorbital nerve. Upgaze with a unilateral 3-g lid load induced reflex contraction of the bilateral orbicularis oculi muscles with ipsilateral dominance. Anesthesia of Müller's muscle precluded the reflex contraction. The orbicularis oculi reflex evoked by stimulation of the trigeminal proprioceptive nerve differed from that by electrical stimulation of the supraorbital nerve in terms of the intensity of current required to induce the reflex, the absence of R1, and duration. The mechanoreceptors in Müller's muscle functions as an extramuscular proprioceptive system to induce reflex contraction of the orbital orbicularis oculi slow-twitch fibers. Whereas reflex contraction of the pretarsal orbicularis fast-twitch fibers functions in spontaneous or reflex blinking, that of the orbital orbicularis oculi slow-twitch fibers may factor in grimacing and blepharospasm.

Trigeminal Proprioception Evoked by Strong Stretching of the Mechanoreceptors in Müller's Muscle Induces Reflex Contraction of the Orbital Orbicularis Oculi Slow-Twitch Muscle Fibers

PubMed Central

Ban, Ryokuya; Ban, Midori; Yuzuriha, Shunsuke

2014-01-01

Objective: The mixed orbicularis oculi muscle lacks an intramuscular proprioceptive system such as muscle spindles, to induce reflex contraction of its slow-twitch fibers. We evaluated whether the mechanoreceptors in Müller's muscle function as extrinsic mechanoreceptors to induce reflex contraction of the slow-twitch fibers of the orbicularis oculi in addition to those of the levator and frontalis muscles. Methods: We evaluated in patients with aponeurosis-disinserted blepharoptosis whether strong stretching of the mechanoreceptors in Müller's muscle from upgaze with unilateral lid load induced reflex contraction of the orbicularis oculi slow-twitch fibers and whether anesthesia of Müller's muscle precluded the contraction. We compared the electromyographic responses of the bilateral orbicularis oculi muscles to unilateral intraoperative direct stimulation of the trigeminal proprioceptive nerve with those to unilateral transcutaneous electrical stimulation of the supraorbital nerve. Results: Upgaze with a unilateral 3-g lid load induced reflex contraction of the bilateral orbicularis oculi muscles with ipsilateral dominance. Anesthesia of Müller's muscle precluded the reflex contraction. The orbicularis oculi reflex evoked by stimulation of the trigeminal proprioceptive nerve differed from that by electrical stimulation of the supraorbital nerve in terms of the intensity of current required to induce the reflex, the absence of R1, and duration. Conclusions: The mechanoreceptors in Müller's muscle functions as an extramuscular proprioceptive system to induce reflex contraction of the orbital orbicularis oculi slow-twitch fibers. Whereas reflex contraction of the pretarsal orbicularis fast-twitch fibers functions in spontaneous or reflex blinking, that of the orbital orbicularis oculi slow-twitch fibers may factor in grimacing and blepharospasm. PMID:25210572

Learning through hand- or typewriting influences visual recognition of new graphic shapes: behavioral and functional imaging evidence.

PubMed

Longcamp, Marieke; Boucard, Céline; Gilhodes, Jean-Claude; Anton, Jean-Luc; Roth, Muriel; Nazarian, Bruno; Velay, Jean-Luc

2008-05-01

Fast and accurate visual recognition of single characters is crucial for efficient reading. We explored the possible contribution of writing memory to character recognition processes. We evaluated the ability of adults to discriminate new characters from their mirror images after being taught how to produce the characters either by traditional pen-and-paper writing or with a computer keyboard. After training, we found stronger and longer lasting (several weeks) facilitation in recognizing the orientation of characters that had been written by hand compared to those typed. Functional magnetic resonance imaging recordings indicated that the response mode during learning is associated with distinct pathways during recognition of graphic shapes. Greater activity related to handwriting learning and normal letter identification was observed in several brain regions known to be involved in the execution, imagery, and observation of actions, in particular, the left Broca's area and bilateral inferior parietal lobules. Taken together, these results provide strong arguments in favor of the view that the specific movements memorized when learning how to write participate in the visual recognition of graphic shapes and letters.

The use of interactive computer vision and robot hand controllers for enhancing manufacturing safety

NASA Technical Reports Server (NTRS)

Marzwell, Neville I.; Jacobus, Charles J.; Peurach, Thomas M.; Mitchell, Brian T.

1994-01-01

Current available robotic systems provide limited support for CAD-based model-driven visualization, sensing algorithm development and integration, and automated graphical planning systems. This paper describes ongoing work which provides the functionality necessary to apply advanced robotics to automated manufacturing and assembly operations. An interface has been built which incorporates 6-DOF tactile manipulation, displays for three dimensional graphical models, and automated tracking functions which depend on automated machine vision. A set of tools for single and multiple focal plane sensor image processing and understanding has been demonstrated which utilizes object recognition models. The resulting tool will enable sensing and planning from computationally simple graphical objects. A synergistic interplay between human and operator vision is created from programmable feedback received from the controller. This approach can be used as the basis for implementing enhanced safety in automated robotics manufacturing, assembly, repair and inspection tasks in both ground and space applications. Thus, an interactive capability has been developed to match the modeled environment to the real task environment for safe and predictable task execution.

The use of interactive computer vision and robot hand controllers for enhancing manufacturing safety

NASA Astrophysics Data System (ADS)

Marzwell, Neville I.; Jacobus, Charles J.; Peurach, Thomas M.; Mitchell, Brian T.

1994-02-01

Current available robotic systems provide limited support for CAD-based model-driven visualization, sensing algorithm development and integration, and automated graphical planning systems. This paper describes ongoing work which provides the functionality necessary to apply advanced robotics to automated manufacturing and assembly operations. An interface has been built which incorporates 6-DOF tactile manipulation, displays for three dimensional graphical models, and automated tracking functions which depend on automated machine vision. A set of tools for single and multiple focal plane sensor image processing and understanding has been demonstrated which utilizes object recognition models. The resulting tool will enable sensing and planning from computationally simple graphical objects. A synergistic interplay between human and operator vision is created from programmable feedback received from the controller. This approach can be used as the basis for implementing enhanced safety in automated robotics manufacturing, assembly, repair and inspection tasks in both ground and space applications. Thus, an interactive capability has been developed to match the modeled environment to the real task environment for safe and predictable task execution.

Automated system function allocation and display format: Task information processing requirements

NASA Technical Reports Server (NTRS)

Czerwinski, Mary P.

1993-01-01

An important consideration when designing the interface to an intelligent system concerns function allocation between the system and the user. The display of information could be held constant, or 'fixed', leaving the user with the task of searching through all of the available information, integrating it, and classifying the data into a known system state. On the other hand, the system, based on its own intelligent diagnosis, could display only relevant information in order to reduce the user's search set. The user would still be left the task of perceiving and integrating the data and classifying it into the appropriate system state. Finally, the system could display the patterns of data. In this scenario, the task of integrating the data is carried out by the system, and the user's information processing load is reduced, leaving only the tasks of perception and classification of the patterns of data. Humans are especially adept at this form of display processing. Although others have examined the relative effectiveness of alphanumeric and graphical display formats, it is interesting to reexamine this issue together with the function allocation problem. Currently, Johnson Space Center is the test site for an intelligent Thermal Control System (TCS), TEXSYS, being tested for use with Space Station Freedom. Expert TCS engineers, as well as novices, were asked to classify several displays of TEXSYS data into various system states (including nominal and anomalous states). Three different display formats were used: fixed, subset, and graphical. The hypothesis tested was that the graphical displays would provide for fewer errors and faster classification times by both experts and novices, regardless of the kind of system state represented within the display. The subset displays were hypothesized to be the second most effective display format/function allocation condition, based on the fact that the search set is reduced in these displays. Both the subset and the graphic display conditions were hypothesized to be processed more efficiently than the fixed display conditions.

25 CFR Appendix A to Subpart E - IRR Program Functions That Are Not Otherwise Contractible

Code of Federal Regulations, 2011 CFR

2011-04-01

... functions listed in this appendix cannot be included in a self-determination contract or self-governance... Assistance Program, Recreational Travel and Tourism, Transit Program, ERFO Program, Presidential initiatives (Millennium Trails, Lewis & Clark, Western Tourism Policy Group); 15. Participating in and supporting tribal...

25 CFR Appendix A to Subpart E - IRR Program Functions That Are Not Otherwise Contractible

Code of Federal Regulations, 2014 CFR

2014-04-01

... functions listed in this appendix cannot be included in a self-determination contract or self-governance... transportation improvement programs developed by tribes or other contractors; 2. Reviewing IRR long-range.... Reviewing long-range transportation plans; 3. Reviewing and approving IRR transportation improvement...

25 CFR Appendix A to Subpart E - IRR Program Functions That Are Not Otherwise Contractible

Code of Federal Regulations, 2012 CFR

2012-04-01

... functions listed in this appendix cannot be included in a self-determination contract or self-governance... transportation improvement programs developed by tribes or other contractors; 2. Reviewing IRR long-range.... Reviewing long-range transportation plans; 3. Reviewing and approving IRR transportation improvement...

Structural Basis of Merlin Tumor Suppressor Functions in Neurofibromatosis-2

DTIC Science & Technology

2013-10-01

Neurofibromatosis -2 PRINCIPAL INVESTIGATOR: Tina Izard CONTRACTING ORGANIZATION: The Scripps Research Institute La Jolla, CA 92037-1000...30September2012-29September2013 4. TITLE AND SUBTITLE Structural Basis of Merlin Tumor Suppressor Functions in Neurofibromatosis -2 5a. CONTRACT...14. ABSTRACT Loss-of-function mutations in the neurofibromatosis -2 (NF2) gene lead to familial and sporadic neurological malignancies in man

Application of Contraction Mappings to the Control of Nonlinear Systems. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Killingsworth, W. R., Jr.

1972-01-01

The theoretical and applied aspects of successive approximation techniques are considered for the determination of controls for nonlinear dynamical systems. Particular emphasis is placed upon the methods of contraction mappings and modified contraction mappings. It is shown that application of the Pontryagin principle to the optimal nonlinear regulator problem results in necessary conditions for optimality in the form of a two point boundary value problem (TPBVP). The TPBVP is represented by an operator equation and functional analytic results on the iterative solution of operator equations are applied. The general convergence theorems are translated and applied to those operators arising from the optimal regulation of nonlinear systems. It is shown that simply structured matrices and similarity transformations may be used to facilitate the calculation of the matrix Green functions and the evaluation of the convergence criteria. A controllability theory based on the integral representation of TPBVP's, the implicit function theorem, and contraction mappings is developed for nonlinear dynamical systems. Contraction mappings are theoretically and practically applied to a nonlinear control problem with bounded input control and the Lipschitz norm is used to prove convergence for the nondifferentiable operator. A dynamic model representing community drug usage is developed and the contraction mappings method is used to study the optimal regulation of the nonlinear system.

Effects of multidimensional pelvic floor muscle training in healthy young women.

PubMed

Talasz, Helena; Kalchschmid, Elisabeth; Kofler, Markus; Lechleitner, Monika

2012-03-01

Cross-sectional and interventional study to assess pelvic floor muscle (PFM) function in healthy young nulliparous women and to determine the effects of a 3-month PFM training program with emphasis on co-contraction of PFM and anterolateral abdominal muscles and on correctly performed coughing patterns. PFM function was assessed by digital vaginal palpation in 40 volunteers and graded according to the 6-point Oxford grading scale. The PFM training program was comprised theoretical instruction, as well as verbal feedback during hands-on instruction and repeated training sessions focussing on strengthening PFM and anterolateral abdominal muscle co-contraction during forced expiration and coughing. At baseline, 30 women (75%) were able to perform normal PFM contractions at rest (Oxford scale score ≥ 3); only 4 of them (10%) presented additional involuntary PFM contractions before and during coughing. The remaining 10 women (25%) were unable to perform voluntary or involuntary PFM contractions. Mean Oxford scale score in the whole group was 3.3 ± 1.7. After completing the PFM training program, 29 women (72.5%) performed cough-related PFM contractions and group mean Oxford scale score increased significantly to 4.2 ± 1.0. The study shows that PFM dysfunction may be detected even in healthy young women. Multidimensional training, however, may significantly improve PFM function.

Assessment of Aberdeen Proving Ground - Army Contracting Command, Contract Management Processes

DTIC Science & Technology

2015-04-11

systems (2008). The Balance Scorecard approach is presented by Niven as “a carefully selected set of quantifiable measures derived from the ...areas of emphasis: the customer, internal processes, learning and growth and financial (Niven, 2003). Both public and private entities recognize the ...contract score card developed by Cullen looks further past the balance scorecard approach by assessing an organization’s contracted functions (2009

A Beginner’s Guide to METAPOST for Creating High-quality Graphics

DTIC Science & Technology

2016-03-31

West Point , NY 10996, USA troy (at) tlhiv dot org http://www.tlhiv.org Abstract Individuals that use TEX (or any of its derivatives) to typeset their...METAPOST. Since graphics drawn with META- POST are simply two dimensional pictures, it is clear that an ordered pair is needed to identify each point in...the picture. The pair data type provides this functionality. Each point in the plane consists of an x (i.e., abscissa) part and a y (i.e., ordinate

Creation of graphic database specifying android arm mechanism work envelope taking into account forbidden zones position

NASA Astrophysics Data System (ADS)

Pritykin, F. N.; Nebritov, V. I.

2017-06-01

The structure of graphic database specifying the shape and the work envelope projection position of an android arm mechanism with various positions of the known in advance forbidden zones is proposed. The technique of analytical assignment of the work envelope based on the methods of analytical geometry and theory of sets is represented. The conducted studies can be applied in creation of knowledge bases for intellectual systems of android control functioning independently in the sophisticated environment.

AiGERM: A logic programming front end for GERM

NASA Technical Reports Server (NTRS)

Hashim, Safaa H.

1990-01-01

AiGerm (Artificially Intelligent Graphical Entity Relation Modeler) is a relational data base query and programming language front end for MCC (Mission Control Center)/STP's (Space Test Program) Germ (Graphical Entity Relational Modeling) system. It is intended as an add-on component of the Germ system to be used for navigating very large networks of information. It can also function as an expert system shell for prototyping knowledge-based systems. AiGerm provides an interface between the programming language and Germ.

Phase Zero Operations for Contingency and Expeditionary Contracting-Keys to Fully Integrating Contracting into Operational Planning and Execution

DTIC Science & Technology

2010-08-02

Cost and Price Analysis & Negotiations (5-2)—DAU CON 217 & CON 218 Certified; MN3318 Contingency Contracting (3-0)—DAU CON 234 Certified; and...MN3315 Advanced Contract Management (4-0)—DAU CON 214 & CON 215 Certified. CDR (Ret) Yoder has recently been published or cited in the following works...certified as the primary guide for all DAU CON 234 course deliveries. Contracting Out Government Procurement Functions: An Analysis (NPS-CM-07-105), E

ChalkBoard: Mapping Functions to Polygons

NASA Astrophysics Data System (ADS)

Matlage, Kevin; Gill, Andy

ChalkBoard is a domain specific language for describing images. The ChalkBoard language is uncompromisingly functional and encourages the use of modern functional idioms. ChalkBoard uses off-the-shelf graphics cards to speed up rendering of functional descriptions. In this paper, we describe the design of the core ChalkBoard language, and the architecture of our static image generation accelerator.

An automated graphics tool for comparative genomics: the Coulson plot generator

PubMed Central

2013-01-01

Background Comparative analysis is an essential component to biology. When applied to genomics for example, analysis may require comparisons between the predicted presence and absence of genes in a group of genomes under consideration. Frequently, genes can be grouped into small categories based on functional criteria, for example membership of a multimeric complex, participation in a metabolic or signaling pathway or shared sequence features and/or paralogy. These patterns of retention and loss are highly informative for the prediction of function, and hence possible biological context, and can provide great insights into the evolutionary history of cellular functions. However, representation of such information in a standard spreadsheet is a poor visual means from which to extract patterns within a dataset. Results We devised the Coulson Plot, a new graphical representation that exploits a matrix of pie charts to display comparative genomics data. Each pie is used to describe a complex or process from a separate taxon, and is divided into sectors corresponding to the number of proteins (subunits) in a complex/process. The predicted presence or absence of proteins in each complex are delineated by occupancy of a given sector; this format is visually highly accessible and makes pattern recognition rapid and reliable. A key to the identity of each subunit, plus hierarchical naming of taxa and coloring are included. A java-based application, the Coulson plot generator (CPG) automates graphic production, with a tab or comma-delineated text file as input and generating an editable portable document format or svg file. Conclusions CPG software may be used to rapidly convert spreadsheet data to a graphical matrix pie chart format. The representation essentially retains all of the information from the spreadsheet but presents a graphically rich format making comparisons and identification of patterns significantly clearer. While the Coulson plot format is highly useful in comparative genomics, its original purpose, the software can be used to visualize any dataset where entity occupancy is compared between different classes. Availability CPG software is available at sourceforge http://sourceforge.net/projects/coulson and http://dl.dropbox.com/u/6701906/Web/Sites/Labsite/CPG.html PMID:23621955

TDIGG - TWO-DIMENSIONAL, INTERACTIVE GRID GENERATION CODE

NASA Technical Reports Server (NTRS)

Vu, B. T.

1994-01-01

TDIGG is a fast and versatile program for generating two-dimensional computational grids for use with finite-difference flow-solvers. Both algebraic and elliptic grid generation systems are included. The method for grid generation by algebraic transformation is based on an interpolation algorithm and the elliptic grid generation is established by solving the partial differential equation (PDE). Non-uniform grid distributions are carried out using a hyperbolic tangent stretching function. For algebraic grid systems, interpolations in one direction (univariate) and two directions (bivariate) are considered. These interpolations are associated with linear or cubic Lagrangian/Hermite/Bezier polynomial functions. The algebraic grids can subsequently be smoothed using an elliptic solver. For elliptic grid systems, the PDE can be in the form of Laplace (zero forcing function) or Poisson. The forcing functions in the Poisson equation come from the boundary or the entire domain of the initial algebraic grids. A graphics interface procedure using the Silicon Graphics (GL) Library is included to allow users to visualize the grid variations at each iteration. This will allow users to interactively modify the grid to match their applications. TDIGG is written in FORTRAN 77 for Silicon Graphics IRIS series computers running IRIX. This package requires either MIT's X Window System, Version 11 Revision 4 or SGI (Motif) Window System. A sample executable is provided on the distribution medium. It requires 148K of RAM for execution. The standard distribution medium is a .25 inch streaming magnetic IRIX tape cartridge in UNIX tar format. This program was developed in 1992.

Microarray Я US: a user-friendly graphical interface to Bioconductor tools that enables accurate microarray data analysis and expedites comprehensive functional analysis of microarray results.

PubMed

Dai, Yilin; Guo, Ling; Li, Meng; Chen, Yi-Bu

2012-06-08

Microarray data analysis presents a significant challenge to researchers who are unable to use the powerful Bioconductor and its numerous tools due to their lack of knowledge of R language. Among the few existing software programs that offer a graphic user interface to Bioconductor packages, none have implemented a comprehensive strategy to address the accuracy and reliability issue of microarray data analysis due to the well known probe design problems associated with many widely used microarray chips. There is also a lack of tools that would expedite the functional analysis of microarray results. We present Microarray Я US, an R-based graphical user interface that implements over a dozen popular Bioconductor packages to offer researchers a streamlined workflow for routine differential microarray expression data analysis without the need to learn R language. In order to enable a more accurate analysis and interpretation of microarray data, we incorporated the latest custom probe re-definition and re-annotation for Affymetrix and Illumina chips. A versatile microarray results output utility tool was also implemented for easy and fast generation of input files for over 20 of the most widely used functional analysis software programs. Coupled with a well-designed user interface, Microarray Я US leverages cutting edge Bioconductor packages for researchers with no knowledge in R language. It also enables a more reliable and accurate microarray data analysis and expedites downstream functional analysis of microarray results.

Muscle forces analysis in the shoulder mechanism during wheelchair propulsion.

PubMed

Lin, Hwai-Ting; Su, Fong-Chin; Wu, Hong-Wen; An, Kai-Nan

2004-01-01

This study combines an ergometric wheelchair, a six-camera video motion capture system and a prototype computer graphics based musculoskeletal model (CGMM) to predict shoulder joint loading, muscle contraction force per muscle and the sequence of muscular actions during wheelchair propulsion, and also to provide an animated computer graphics model of the relative interactions. Five healthy male subjects with no history of upper extremity injury participated. A conventional manual wheelchair was equipped with a six-component load cell to collect three-dimensional forces and moments experienced by the wheel, allowing real-time measurement of hand/rim force applied by subjects during normal wheelchair operation. An ExpertVision six-camera video motion capture system collected trajectory data of markers attached on anatomical positions. The CGMM was used to simulate and animate muscle action by using an optimization technique combining observed muscular motions with physiological constraints to estimate muscle contraction forces during wheelchair propulsion. The CGMM provides results that satisfactorily match the predictions of previous work, disregarding minor differences which presumably result from differing experimental conditions, measurement technologies and subjects. Specifically, the CGMM shows that the supraspinatus, infraspinatus, anterior deltoid, pectoralis major and biceps long head are the prime movers during the propulsion phase. The middle and posterior deltoid and supraspinatus muscles are responsible for arm return during the recovery phase. CGMM modelling shows that the rotator cuff and pectoralis major play an important role during wheelchair propulsion, confirming the known risk of injury for these muscles during wheelchair propulsion. The CGMM successfully transforms six-camera video motion capture data into a technically useful and visually interesting animated video model of the shoulder musculoskeletal system. The CGMM further yields accurate estimates of muscular forces during motion, indicating that this prototype modelling and analysis technique will aid in study, analysis and therapy of the mechanics and underlying pathomechanics involved in various musculoskeletal overuse syndromes.

The Use of Interactive Raster Graphics in the Display and Manipulation of Multidimensional Data

NASA Technical Reports Server (NTRS)

Anderson, D. C.

1981-01-01

Techniques for the review, display, and manipulation of multidimensional data are developed and described. Multidimensional data is meant in this context to describe scalar data associated with a three dimensional geometry or otherwise too complex to be well represented by traditional graphs. Raster graphics techniques are used to display a shaded image of a three dimensional geometry. The use of color to represent scalar data associated with the geometries in shaded images is explored. Distinct hues are associated with discrete data ranges, thus emulating the traditional representation of data with isarithms, or lines of constant numerical value. Data ranges are alternatively associated with a continuous spectrum of hues to show subtler data trends. The application of raster graphics techniques to the display of bivariate functions is explored.

XGI: a graphical interface for XQuery creation.

PubMed

Li, Xiang; Gennari, John H; Brinkley, James F

2007-10-11

XML has become the default standard for data exchange among heterogeneous data sources, and in January 2007 XQuery (XML Query language) was recommended by the World Wide Web Consortium as the query language for XML. However, XQuery is a complex language that is difficult for non-programmers to learn. We have therefore developed XGI (XQuery Graphical Interface), a visual interface for graphically generating XQuery. In this paper we demonstrate the functionality of XGI through its application to a biomedical XML dataset. We describe the system architecture and the features of XGI in relation to several existing querying systems, we demonstrate the system's usability through a sample query construction, and we discuss a preliminary evaluation of XGI. Finally, we describe some limitations of the system, and our plans for future improvements.

Motor cortical representation of the pelvic floor muscles.

PubMed

Schrum, A; Wolff, S; van der Horst, C; Kuhtz-Buschbeck, J P

2011-07-01

Pelvic floor muscle training involves rhythmical voluntary contractions of the external urethral sphincter and ancillary pelvic floor muscles. The representation of these muscles in the motor cortex has not been located precisely and unambiguously. We used functional magnetic resonance imaging to determine brain activity during slow and fast pelvic floor contractions. Cerebral responses were recorded in 17 healthy male volunteers, 21 to 47 years old, with normal bladder control. Functional magnetic resonance imaging was performed during metronome paced slow (0.25 Hertz) and fast (0.7 Hertz) contractions of the pelvic floor that mimicked the interruption of voiding. To study the somatotopy of the cortical representations, flexion-extension movements of the right toes were performed as a control task. Functional magnetic resonance imaging during pelvic floor contractions detected activity of the supplementary motor area in the medial wall and of the midcingulate cortex, insula, posterior parietal cortex, putamen, thalamus, cerebellar vermis and upper ventral pons. There were no significant differences in activation between slow and fast contractions. Toe movements involved significantly stronger activity of the paracentral lobule (ie the medial primary motor cortex) than did the pelvic floor contractions. Otherwise the areas active during pelvic floor and leg muscle contractions overlapped considerably. The motor cortical representation of pelvic floor muscles is located mostly in the supplementary motor area. It extends further ventrally and anteriorly than the representation of distal leg muscles. Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Near-infrared spectroscopy of the bladder: a new technique for studying lower urinary tract function in health and disease

NASA Astrophysics Data System (ADS)

Shadgan, Babak; Afshar, Kourosh; Stothers, Lynn; Macnab, Andrew

2010-02-01

Background: Continuous wave near-infrared spectroscopy (NIRS) can monitor chromophore change in the bladder detrusor muscle during voiding; oxygenation and hemodynamic data derived differ in health and disease. Application of wireless NIRS for evaluation of voiding dysfunction would benefit children. Methods: Subjects: 20 children (4-17 yrs) [5 normal, 15 with urinary tract pathology]. Instrumentation: self-contained device weight 84 gm; 3 paired light emitting diodes (760/850 nm) in a spatially resolved configuration; source-detector separation distances (30, 35 and 40 mm); silicon photodiode detector; and Bluetooth®. Procedure: Transcutaneous monitoring (midline abdominal skin 2 cm above pubis) during spontaneous voiding (bladder contraction) of oxygenated (O2Hb), deoxygenated (HHb) and total hemoglobin (tHb) and tissue oxygen saturation index (TSI %) at 10 Hz. Results: All 20 trials produced clear graphic data with no movement effect evident. Comparison of patterns of chromophore change between normal and symptomatic subjects revealed trend differences in O2Hb and tHb. (Normal positive; Symptomatic negative, and TSI% fell in symptomatic group). Conclusions: Wireless NIRS is technically feasible in ambulant children. Negative trends in chromophore concentration and falls in TSI% suggest a hemodynamic impairment may underlie some forms of voiding dysfunction, with abnormal physiology involving the microcirculation possibly resulting in muscle fatigue during voiding.

Maximising profits for an EPQ model with unreliable machine and rework of random defective items

NASA Astrophysics Data System (ADS)

Pal, Brojeswar; Sankar Sana, Shib; Chaudhuri, Kripasindhu

2013-03-01

This article deals with an economic production quantity (EPQ) model in an imperfect production system. The production system may undergo in 'out-of-control' state from 'in-control' state, after a certain time that follows a probability density function. The density function varies with reliability of the machinery system that may be controlled by new technologies, investing more costs. The defective items produced in 'out-of-control' state are reworked at a cost just after the regular production time. Occurrence of the 'out-of-control' state during or after regular production-run time is analysed and also graphically illustrated separately. Finally, an expected profit function regarding the inventory cost, unit production cost and selling price is maximised analytically. Sensitivity analysis of the model with respect to key parameters of the system is carried out. Two numerical examples are considered to test the model and one of them is illustrated graphically.

Outsourcing Instruction: Issues for Public Colleges and Universities. Policy Matters: A Higher Education Policy Brief

ERIC Educational Resources Information Center

Russell, Alene

2010-01-01

Outsourcing--defined as an "institution's decision to contract with an external organization to provide a traditional function or service" (IHEP, 2005)--is nothing new to higher education. For decades, institutions have been "contracting out" or "privatizing" a variety of operational functions, hoping to reduce costs,…

24 CFR 964.225 - Resident management requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... management functions for which the HA is responsible to HUD under the ACC and any other functions not inconsistent with the ACC and applicable state and local laws, regulations and licensing requirements. (e... HUD approval of contracts contained in the ACC do not apply to the decision of a HA to contract with a...

78 FR 13710 - Analysis of FY 2011 Service Contract Inventories

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... to administer the National Labor Relations Act, the primary law governing relations between and among... agencies are requested to conduct an analysis of special interest functions within the FY 2011 Service... functions by pulling information on all FY 2011 service contracts over $25,000 from FPDS-NG with the special...

Function algorithms for MPP scientific subroutines, volume 1

NASA Technical Reports Server (NTRS)

Gouch, J. G.

1984-01-01

Design documentation and user documentation for function algorithms for the Massively Parallel Processor (MPP) are presented. The contract specifies development of MPP assembler instructions to perform the following functions: natural logarithm; exponential (e to the x power); square root; sine; cosine; and arctangent. To fulfill the requirements of the contract, parallel array and solar implementations for these functions were developed on the PDP11/34 Program Development and Management Unit (PDMU) that is resident at the MPP testbed installation located at the NASA Goddard facility.

The explicit form of the rate function for semi-Markov processes and its contractions

NASA Astrophysics Data System (ADS)

Sughiyama, Yuki; Kobayashi, Testuya J.

2018-03-01

We derive the explicit form of the rate function for semi-Markov processes. Here, the ‘random time change trick’ plays an essential role. Also, by exploiting the contraction principle of large deviation theory to the explicit form, we show that the fluctuation theorem (Gallavotti-Cohen symmetry) holds for semi-Markov cases. Furthermore, we elucidate that our rate function is an extension of the level 2.5 rate function for Markov processes to semi-Markov cases.

Configurable software for satellite graphics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hartzman, P D

An important goal in interactive computer graphics is to provide users with both quick system responses for basic graphics functions and enough computing power for complex calculations. One solution is to have a distributed graphics system in which a minicomputer and a powerful large computer share the work. The most versatile type of distributed system is an intelligent satellite system in which the minicomputer is programmable by the application user and can do most of the work while the large remote machine is used for difficult computations. At New York University, the hardware was configured from available equipment. The levelmore » of system intelligence resulted almost completely from software development. Unlike previous work with intelligent satellites, the resulting system had system control centered in the satellite. It also had the ability to reconfigure software during realtime operation. The design of the system was done at a very high level using set theoretic language. The specification clearly illustrated processor boundaries and interfaces. The high-level specification also produced a compact, machine-independent virtual graphics data structure for picture representation. The software was written in a systems implementation language; thus, only one set of programs was needed for both machines. A user can program both machines in a single language. Tests of the system with an application program indicate that is has very high potential. A major result of this work is the demonstration that a gigantic investment in new hardware is not necessary for computing facilities interested in graphics.« less

A pilot study comparing mouse and mouse-emulating interface devices for graphic input.

PubMed

Kanny, E M; Anson, D K

1991-01-01

Adaptive interface devices make it possible for individuals with physical disabilities to use microcomputers and thus perform many tasks that they would otherwise be unable to accomplish. Special equipment is available that purports to allow functional access to the computer for users with disabilities. As technology moves from purely keyboard applications to include graphic input, it will be necessary for assistive interface devices to support graphics as well as text entry. Headpointing systems that emulate the mouse in combination with on-screen keyboards are of particular interest to persons with severe physical impairment such as high level quadriplegia. Two such systems currently on the market are the HeadMaster and the Free Wheel. The authors have conducted a pilot study comparing graphic input speed using the mouse and two headpointing interface systems on the Macintosh computer. The study used a single subject design with six able-bodied subjects, to establish a baseline for comparison with persons with severe disabilities. Results of these preliminary data indicated that the HeadMaster was nearly as effective as the mouse and that it was superior to the Free Wheel for graphics input. This pilot study, however, demonstrated several experimental design problems that need to be addressed to make the study more robust. It also demonstrated the need to include the evaluation of text input so that the effectiveness of the interface devices with text and graphic input could be compared.

Contraction of the Ventral Abdomen Potentiates Extracardiac Retrograde Hemolymph Propulsion in the Mosquito Hemocoel

PubMed Central

Andereck, Jonathan W.; King, Jonas G.; Hillyer, Julián F.

2010-01-01

Background Hemolymph circulation in mosquitoes is primarily controlled by the contractile action of a dorsal vessel that runs underneath the dorsal midline and is subdivided into a thoracic aorta and an abdominal heart. Wave-like peristaltic contractions of the heart alternate in propelling hemolymph in anterograde and retrograde directions, where it empties into the hemocoel at the terminal ends of the insect. During our analyses of hemolymph propulsion in Anopheles gambiae, we observed periodic ventral abdominal contractions and hypothesized that they promote extracardiac hemolymph circulation in the abdominal hemocoel. Methodology/Principal Findings We devised methods to simultaneously analyze both heart and abdominal contractions, as well as to measure hemolymph flow in the abdominal hemocoel. Qualitative and quantitative analyses revealed that ventral abdominal contractions occur as series of bursts that propagate in the retrograde direction. Periods of ventral abdominal contraction begin only during periods of anterograde heart contraction and end immediately following a heartbeat directional reversal, suggesting that ventral abdominal contractions function to propel extracardiac hemolymph in the retrograde direction. To test this functional role, fluorescent microspheres were intrathoracically injected and their trajectory tracked throughout the hemocoel. Quantitative measurements of microsphere movement in extracardiac regions of the abdominal cavity showed that during periods of abdominal contractions hemolymph flows in dorsal and retrograde directions at a higher velocity and with greater acceleration than during periods of abdominal rest. Histochemical staining of the abdominal musculature then revealed that ventral abdominal contractions result from the contraction of intrasegmental lateral muscle fibers, intersegmental ventral muscle bands, and the ventral transverse muscles that form the ventral diaphragm. Conclusions/Significance These data show that abdominal contractions potentiate extracardiac retrograde hemolymph propulsion in the abdominal hemocoel during periods of anterograde heart flow. PMID:20886066

GKS utilities for FORTRAN-77

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beach, R.C.

1992-01-01

This document describes a number of subroutines that can be useful in GKS graphic applications programmed in FORTRAN-77. The algorithms described here include subroutines to do the following: (1) Draw text characters in a more flexible manner than is possible with basic GKS. (2) Project two-dimensional and three-dimensional space onto two-dimensional space. (3) Draw smooth curves. (4) Draw two-dimensional projections of complex three-dimensional objects. FORTRAN-77 is described in American National Standard, Programming Language, FORTRAN. GKS is described in American National Standard for Information Systems: Computer Graphics -- Graphical Kernel System (GKS) Functional Description and the FORTRAN-77 interface is described inmore » American National Standard for Information Systems: Computer Graphics -- Graphical Kernel System (GKS) FORTRAN Binding. All of the subroutine names and additional enumeration types that will be described in this document begin with the letters ``GZ.`` Since GKS itself does not have any subroutine names or enumeration types that begin with these letters, no confusion between the usual GKS subroutines and the ones described here should occur. Many concepts will have to be defined in the following chapters. When a concept is first encountered, it will be given in italics. The information around the italicized word or phrase may be taken as its definition.« less

GKS utilities for FORTRAN-77

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beach, R.C.

1992-01-01

This document describes a number of subroutines that can be useful in GKS graphic applications programmed in FORTRAN-77. The algorithms described here include subroutines to do the following: (1) Draw text characters in a more flexible manner than is possible with basic GKS. (2) Project two-dimensional and three-dimensional space onto two-dimensional space. (3) Draw smooth curves. (4) Draw two-dimensional projections of complex three-dimensional objects. FORTRAN-77 is described in American National Standard, Programming Language, FORTRAN. GKS is described in American National Standard for Information Systems: Computer Graphics -- Graphical Kernel System (GKS) Functional Description and the FORTRAN-77 interface is described inmore » American National Standard for Information Systems: Computer Graphics -- Graphical Kernel System (GKS) FORTRAN Binding. All of the subroutine names and additional enumeration types that will be described in this document begin with the letters GZ.'' Since GKS itself does not have any subroutine names or enumeration types that begin with these letters, no confusion between the usual GKS subroutines and the ones described here should occur. Many concepts will have to be defined in the following chapters. When a concept is first encountered, it will be given in italics. The information around the italicized word or phrase may be taken as its definition.« less

Inhibition of xanthine oxidase reduces oxidative stress and improves skeletal muscle function in response to electrically stimulated isometric contractions in aged mice

PubMed Central

Ryan, Michael J.; Jackson, Janna R.; Hao, Yanlei; Leonard, Stephen S.; Alway, Stephen E.

2012-01-01

Oxidative stress is a putative factor responsible for reducing function and increasing apoptotic signaling in skeletal muscle with aging. This study examined the contribution and functional significance of the xanthine oxidase enzyme as a potential source of oxidant production in aged skeletal muscle during repetitive in situ electrically stimulated isometric contractions. Xanthine oxidase activity was inhibited in young adult and aged mice via a subcutaneously placed time release (2.5 mg/day) allopurinol pellet, 7 days prior to the start of in situ electrically stimulated isometric contractions. Gastrocnemius muscles were electrically activated with 20 maximal contractions for three consecutive days. Xanthine oxidase activity was 65% greater in the gastrocnemius muscle of aged mice compared to young mice. Xanthine oxidase activity also increased after in situ electrically stimulated isometric contractions in muscles from both young (33%) and aged (28%) mice, relative to contralateral non-contracted muscles. Allopurinol attenuated the exercise-induced increase in oxidative stress, but it did not affect the elevated basal levels of oxidative stress that was associated with aging. In addition, inhibition of xanthine oxidase activity decreased caspase 3 activity, but it had no effect on other markers of mitochondrial associated apoptosis. Our results show that compared to control conditions, suppression of xanthine oxidase activity by allopurinol reduced xanthine oxidase activity, H2O2 levels, lipid peroxidation and caspase-3 activity, prevented the in situ electrically stimulated isometric contraction-induced loss of glutathione, prevented the increase of catalase and copper-zinc superoxide dismutase activities, and increased maximal isometric force in the plantar flexor muscles of aged mice after repetitive electrically evoked contractions. PMID:21530649

Effects of hand configuration on muscle force coordination, co-contraction and concomitant intermuscular coupling during maximal isometric flexion of the fingers.

PubMed

Charissou, Camille; Amarantini, David; Baurès, Robin; Berton, Eric; Vigouroux, Laurent

2017-11-01

The mechanisms governing the control of musculoskeletal redundancy remain to be fully understood. The hand is highly redundant, and shows different functional role of extensors according to its configuration for a same functional task of finger flexion. Through intermuscular coherence analysis combined with hand musculoskeletal modelling during maximal isometric hand contractions, our aim was to better understand the neural mechanisms underlying the control of muscle force coordination and agonist-antagonist co-contraction. Thirteen participants performed maximal isometric flexions of the fingers in two configurations: power grip (Power) and finger-pressing on a surface (Press). Hand kinematics and force/moment measurements were used as inputs in a musculoskeletal model of the hand to determine muscular tensions and co-contraction. EMG-EMG coherence analysis was performed between wrist and finger flexors and extensor muscle pairs in alpha, beta and gamma frequency bands. Concomitantly with tailored muscle force coordination and increased co-contraction between Press and Power (mean difference: 48.08%; p < 0.05), our results showed muscle-pair-specific modulation of intermuscular coupling, characterized by pair-specific modulation of EMG-EMG coherence between Power and Press (p < 0.05), and a negative linear association between co-contraction and intermuscular coupling for the ECR/FCR agonist-antagonist muscle pair (r = - 0.65; p < 0.05). This study brings new evidence that pair-specific modulation of EMG-EMG coherence is related to modulation of muscle force coordination during hand contractions. Our results highlight the functional importance of intermuscular coupling as a mechanism contributing to the control of muscle force synergies and agonist-antagonist co-contraction.

Mechanical characteristics of distension-evoked peristaltic contractions in the esophagus of systemic sclerosis patients.

PubMed

Gregersen, Hans; Villadsen, Gerda E; Liao, Donghua

2011-12-01

Systemic sclerosis (SS) patients with severe esophageal affection have impaired peristalsis. However, motor function evaluated in vivo by manometry and fluoroscopy does not provide detailed information about the individual contraction cycles. To apply, for the first time in gastrointestinal (GI) patients, a method and principles modified from cardiac research to study esophageal muscle behavior in SS patients. Muscle contraction cycles were analyzed using pressure-cross-sectional area (P-CSA) loops during distension pressure up to 5 kPa. The probe with bag and electrodes for CSA measurements was positioned 7 and 15 cm above the lower esophageal sphincter (LES) in eleven healthy volunteers and eleven SS patients. The P-CSA, the wall tension, Δtension (afterload tension - preload tension), contraction velocity, work output (area of the tension-CSA loops), and power output (preload tension × CSA rate) were analyzed. The P-CSA loops consisted of phases with relaxation and contraction behavior. The tension-stretch ratio loops in patients were shifted to the left at both distension sites, indicative of a stiffer wall in patients. Lower contraction amplitudes and smaller P-CSA loops were observed for the SS patients. The work output, power output, Δtension, and contraction velocity were lower in patients (P < 0.001). Association was found between disease duration and the work output, Δtension, and velocity at pressure steps higher than 3 kPa (P < 0.05). Distension-evoked esophageal contraction can be studied in vivo and analyzed with advanced methods. Increased esophageal stiffness and impaired muscle function that depended on disease duration were observed for SS patients. The analysis may be useful for characterization of other diseases affecting GI function.

Numerical-graphical method for describing the creep of damaged highly filled polymer materials

NASA Astrophysics Data System (ADS)

Bykov, D. L.; Martynova, E. D.; Mel'nikov, V. P.

2015-09-01

A method for describing the creep behavior until fracture of a highly filled polymer material previously damaged in preliminary tests is proposed. The constitutive relations are the relations of nonlinear endochronic theory of aging viscoelastic materials (NETAVEM) [1]. The numerical-graphical method for identifying the functions occurring in NETAVEM, which was proposed in [2] for describing loading processes at a constant strain rate, is used here for the first time in creep theory. We use the results of experiments with undamaged and preliminary damaged specimens under the action of the same constant tensile loads. The creep kernel is determined in experiments with an undamaged specimen. The reduced time function contained in NETAVEM is determined from the position of points corresponding to the same values of strain on the creep curves of the damaged and undamaged specimens. An integral equation is solved to obtain the aging function, and then the viscosity function is determined. The knowledge of all functions contained in the constitutive relations permits solving the creep problem for products manufactured from a highly filled polymer material.

Blood pressure and mesenteric resistance arterial function after spaceflight

NASA Technical Reports Server (NTRS)

Hatton, Daniel C.; Yue, Qi; Chapman, Justin; Xue, Hong; Dierickx, Jacqueline; Roullet, Chantal; Coste, Sarah; Roullet, Jean Baptiste; McCarron, David A.

2002-01-01

Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.

New Actions Upon Old Objects: A New Ontological Perspective on Functions.

ERIC Educational Resources Information Center

Schwarz, Baruch; Dreyfus, Tommy

1995-01-01

A computer microworld called Triple Representation Model uses graphical, tabular, and algebraic representations to influence conceptions of function. A majority of students were able to cope with partial data, recognize invariants while coordinating actions among representations, and recognize invariants while creating and comparing different…

Characterization of solar cells for space applications. Volume 13: Electrical characteristics of Hughes LPE gallium arsenide solar cells as a function of intensity and temperature

NASA Technical Reports Server (NTRS)

Anspaugh, B. E.; Beckert, D. M.; Downing, R. G.; Miyahira, T. F.; Weiss, R. S.

1980-01-01

Electrical characteristics of Hughes Liquid phase epitaxy, P/N gallium aluminum arsenide solar cells are presented in graphical and tabular format as a function of solar illumination intensity and temperature.

Skeletal muscle contraction in protecting joints and bones by absorbing mechanical impacts

NASA Astrophysics Data System (ADS)

Rudenko, O. V.; Tsyuryupa, S.; Sarvazyan, A.

2016-09-01

We have previously hypothesized that the dissipation of mechanical energy of external impact is a fundamental function of skeletal muscle in addition to its primary function to convert chemical energy into mechanical energy. In this paper, a mathematical justification of this hypothesis is presented. First, a simple mechanical model, in which the muscle is considered as a simple Hookean spring, is considered. This analysis serves as an introduction to the consideration of a biomechanical model taking into account the molecular mechanism of muscle contraction, kinetics of myosin bridges, sarcomere dynamics, and tension of muscle fibers. It is shown that a muscle behaves like a nonlinear and adaptive spring tempering the force of impact and increasing the duration of the collision. The temporal profiles of muscle reaction to the impact as functions of the levels of muscle contraction, durations of the impact front, and the time constants of myosin bridges closing, are obtained. The absorption of mechanical shock energy is achieved due to the increased viscoelasticity of the contracting skeletal muscle. Controlling the contraction level allows for the optimization of the stiffness and viscosity of the muscle necessary for the protection of the joints and bones.

Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis.

PubMed

Ito, Hiroshi; Ikoma, Yoko; Seki, Chie; Kimura, Yasuyuki; Kawaguchi, Hiroshi; Takuwa, Hiroyuki; Ichise, Masanori; Suhara, Tetsuya; Kanno, Iwao

2017-05-01

Objectives In PET studies for neuroreceptors, tracer kinetics are described by the two-tissue compartment model (2-TCM), and binding parameters, including the total distribution volume (V T ), non-displaceable distribution volume (V ND ), and binding potential (BP ND ), can be determined from model parameters estimated by kinetic analysis. The stability of binding parameter estimates depends on the kinetic characteristics of radioligands. To describe these kinetic characteristics, we previously developed a two-phase graphic plot analysis in which V ND and V T can be estimated from the x-intercept of regression lines for early and delayed phases, respectively. In this study, we applied this graphic plot analysis to visual evaluation of the kinetic characteristics of radioligands for neuroreceptors, and investigated a relationship between the shape of these graphic plots and the stability of binding parameters estimated by the kinetic analysis with 2-TCM in simulated brain tissue time-activity curves (TACs) with various binding parameters. Methods 90-min TACs were generated with the arterial input function and assumed kinetic parameters according to 2-TCM. Graphic plot analysis was applied to these simulated TACs, and the curvature of the plot for each TAC was evaluated visually. TACs with several noise levels were also generated with various kinetic parameters, and the bias and variation of binding parameters estimated by kinetic analysis were calculated in each TAC. These bias and variation were compared with the shape of graphic plots. Results The graphic plots showed larger curvature for TACs with higher specific binding and slower dissociation of specific binding. The quartile deviations of V ND and BP ND determined by kinetic analysis were smaller for radioligands with slow dissociation. Conclusions The larger curvature of graphic plots for radioligands with slow dissociation might indicate a stable determination of V ND and BP ND by kinetic analysis. For investigation of the kinetics of radioligands, such kinetic characteristics should be considered.

A Feasibility Assessment of a Single Contracting Office for Common-User Transportation Services

DTIC Science & Technology

1990-09-01

feasibility of consolidating the contracting functions that purchase common-user transportation services and occurs within the headquarters of the three...responsible for and the dollars spent in the procurement of those services. A complete breakdown of the services purchased is in chapter three. The...34 while contracting is the process a’contracting officer completes to satisfy a funded purchase request generated in response to a identified

Designation of Contracting Officers Representatives and Oversight Framework Could Be Improved for Contracts in Afghanistan

DTIC Science & Technology

2016-08-30

certifying official in the certification of vouchers for payment. 21 U.S. Office of Government Ethics Form 450, “Confidential Financial Disclosure Report...contracting officer to perform specific technical or administrative functions for Government contracts. We performed this audit in response to a...February 2015 U.S. Forces−Afghanistan policy memorandum requesting the DoD Office of Inspector General to review COR performance in the Combined

25 CFR Appendix A to Subpart E - IRR Program Functions That Are Not Otherwise Contractible

Code of Federal Regulations, 2013 CFR

2013-04-01

... contract payments; 7. Approving contract modifications; 8. Processing claims and disputes with tribal... assure compliance with or exceeding Federal standards for IRR design and construction. G. Construction: 1... inspection and acceptance of project documents as-built drawings on behalf of BIA as facility owner; and 11...

Vardenafil inhibiting parasympathetic function of tracheal smooth muscle.

PubMed

Lee, Fei-Peng; Chao, Pin-Zhir; Wang, Hsing-Won

2018-07-01

Levitra, a phosphodiesterase-5 (PDE5) inhibitor, is the trade name of vardenafil. Nowadays, it is applied to treatment of erectile dysfunction. PDE5 inhibitors are employed to induce dilatation of the vascular smooth muscle. The effect of Levitra on impotency is well known; however, its effect on the tracheal smooth muscle has rarely been explored. When administered for sexual symptoms via oral intake or inhalation, Levitra might affect the trachea. This study assessed the effects of Levitra on isolated rat tracheal smooth muscle by examining its effect on resting tension of tracheal smooth muscle, contraction caused by 10 -6  M methacholine as a parasympathetic mimetic, and electrically induced tracheal smooth muscle contractions. The results showed that adding methacholine to the incubation medium caused the trachea to contract in a dose-dependent manner. Addition of Levitra at doses of 10 -5  M or above elicited a significant relaxation response to 10 -6  M methacholine-induced contraction. Levitra could inhibit electrical field stimulation-induced spike contraction. It alone had minimal effect on the basal tension of the trachea as the concentration increased. High concentrations of Levitra could inhibit parasympathetic function of the trachea. Levitra when administered via oral intake might reduce asthma attacks in impotent patients because it might inhibit parasympathetic function and reduce methacholine-induced contraction of the tracheal smooth muscle. Copyright © 2018. Published by Elsevier Taiwan LLC.

Systems Biology Graphical Notation: Activity Flow language Level 1 Version 1.2.

PubMed

Mi, Huaiyu; Schreiber, Falk; Moodie, Stuart; Czauderna, Tobias; Demir, Emek; Haw, Robin; Luna, Augustin; Le Novère, Nicolas; Sorokin, Anatoly; Villéger, Alice

2015-09-04

The Systems Biological Graphical Notation (SBGN) is an international community effort for standardized graphical representations of biological pathways and networks. The goal of SBGN is to provide unambiguous pathway and network maps for readers with different scientific backgrounds as well as to support efficient and accurate exchange of biological knowledge between different research communities, industry, and other players in systems biology. Three SBGN languages, Process Description (PD), Entity Relationship (ER) and Activity Flow (AF), allow for the representation of different aspects of biological and biochemical systems at different levels of detail. The SBGN Activity Flow language represents the influences of activities among various entities within a network. Unlike SBGN PD and ER that focus on the entities and their relationships with others, SBGN AF puts the emphasis on the functions (or activities) performed by the entities, and their effects to the functions of the same or other entities. The nodes (elements) describe the biological activities of the entities, such as protein kinase activity, binding activity or receptor activity, which can be easily mapped to Gene Ontology molecular function terms. The edges (connections) provide descriptions of relationships (or influences) between the activities, e.g., positive influence and negative influence. Among all three languages of SBGN, AF is the closest to signaling pathways in biological literature and textbooks, but its well-defined semantics offer a superior precision in expressing biological knowledge.

Quantifying Uncertainty in Early Lifecycle Cost Estimation for DOD Major Defense Acquisition Programs

DTIC Science & Technology

2012-10-31

Prod uc F22 cond 1 Contract cond 2 Function cond 3 CONOPS For C2 systems, how often does Strategic Vision change? Records show that...System De cond 3 CapDef JTRS cond 1 InterOpera cond 2 Prod uctio F22 cond 1 Contract cond 2 Functional cond 3 CONOPS The Materiel

48 CFR 237.102-70 - Prohibition on contracting for firefighting or security-guard functions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... undertaken in response to the terrorist attacks on the United States on September 11, 2001, if— (i) Without...) is for the performance of a function under contract on September 24, 1983; or (4) The contract— (i... performance will not extend beyond September 30, 2012; and (iv) The total number of personnel employed to...

The Evolution of Spreadsheets.

ERIC Educational Resources Information Center

Schuyler, Michael

1985-01-01

Discusses basic features and functions of spreadsheet programs and describes additional capabilities (editing, windowing, graphics, and word processing) of two second-generation spreadsheet programs: Lotus 1-2-3 and Symphony. (MBR)

Hypergeometric Gaussian beam and its propagation in turbulence

NASA Astrophysics Data System (ADS)

Eyyuboğlu, Halil Tanyer; Cai, Yangjian

2012-10-01

We study propagation characteristics of hypergeometric Gaussian beam in turbulence. In this context, we formulate the receiver plane intensity using extended Huygens-Fresnel integral. From the graphical results, it is seen that, after propagation, hypergeometric Gaussian will in general assume the shape of a dark hollow beam at topological charges other than zero. Increasing values of topological charge will make the beam broader with steeper walls. On the other hand, higher values of hollowness parameter will contract into a narrower shape. Raising the topological charge or the hollowness parameter individually will cause outer rings to appear. Both increased levels of turbulence and longer propagation distances will accelerate the beam evolution and help reach the final Gaussian shape sooner. At lower wavelengths, there will be less beam spreading.

Programming a Detector Emulator on NI's FlexRIO Platform

NASA Astrophysics Data System (ADS)

Gervais, Michelle; Crawford, Christopher; Sprow, Aaron; Nab Collaboration

2017-09-01

Recently digital detector emulators have been on the rise as a means to test data acquisition systems and analysis toolkits from a well understood data set. National Instruments' PXIe-7962R FPGA module and Active Technologies AT-1212 DAC module provide a customizable platform for analog output. Using a graphical programming language, we have developed a system capable of producing two time-correlated channels of analog output which sample unique amplitude spectra to mimic nuclear physics experiments. This system will be used to model the Nab experiment, in which a prompt beta decay electron is followed by a slow proton according to a defined time distribution. We will present the results of our work and discuss further development potential. DOE under Contract DE-SC0008107.

A practical guide to the Piccolo autopilot

NASA Astrophysics Data System (ADS)

Mornhinweg, Anton

In support of a UAV contract the Piccolo SL and Piccolo II autopilots were installed and operated on various aircraft. Numerous problems with the autopilot setup and analysis processes were found along with numerous problems with documentation and autopilot system information. Major areas of concern are identified along with objectives to eliminate the major areas of concern. Piccolo simulator vehicle gain calculations and Piccolo generation 2 version 2.1.4 control laws are reverse engineered. A complete modeling guide is created. Methods are developed to perform and analyze doublet maneuvers. A series of flight procedures are outlined that include methods for tuning gains. A series of MATLAB graphical user interfaces were created to analyze flight data and pertinent control loop data for gain tuning.

Map showing geologic terranes of the Hailey 1 degree x 2 degrees quadrangle and the western part of the Idaho Falls 1 degree x 2 degrees quadrangle, south-central Idaho

USGS Publications Warehouse

Worl, R.G.; Johnson, K.M.

1995-01-01

The paper version of Map Showing Geologic Terranes of the Hailey 1x2 Quadrangle and the western part of the Idaho Falls 1x2 Quadrangle, south-central Idaho was compiled by Ron Worl and Kate Johnson in 1995. The plate was compiled on a 1:250,000 scale topographic base map. TechniGraphic System, Inc. of Fort Collins Colorado digitized this map under contract for N.Shock. G.Green edited and prepared the digital version for publication as a geographic information system database. The digital geologic map database can be queried in many ways to produce a variety of geologic maps.

Developing a Graphical User Interface for the ALSS Crop Planning Tool

NASA Technical Reports Server (NTRS)

Koehlert, Erik

1997-01-01

The goal of my project was to create a graphical user interface for a prototype crop scheduler. The crop scheduler was developed by Dr. Jorge Leon and Laura Whitaker for the ALSS (Advanced Life Support System) program. The addition of a system-independent graphical user interface to the crop planning tool will make the application more accessible to a wider range of users and enhance its value as an analysis, design, and planning tool. My presentation will demonstrate the form and functionality of this interface. This graphical user interface allows users to edit system parameters stored in the file system. Data on the interaction of the crew, crops, and waste processing system with the available system resources is organized and labeled. Program output, which is stored in the file system, is also presented to the user in performance-time plots and organized charts. The menu system is designed to guide the user through analysis and decision making tasks, providing some help if necessary. The Java programming language was used to develop this interface in hopes of providing portability and remote operation.

The relevance of error analysis in graphical symbols evaluation.

PubMed

Piamonte, D P

1999-01-01

In an increasing number of modern tools and devices, small graphical symbols appear simultaneously in sets as parts of the human-machine interfaces. The presence of each symbol can influence the other's recognizability and correct association to its intended referents. Thus, aside from correct associations, it is equally important to perform certain error analysis of the wrong answers, misses, confusions, and even lack of answers. This research aimed to show how such error analyses could be valuable in evaluating graphical symbols especially across potentially different user groups. The study tested 3 sets of icons representing 7 videophone functions. The methods involved parameters such as hits, confusions, missing values, and misses. The association tests showed similar hit rates of most symbols across the majority of the participant groups. However, exploring the error patterns helped detect differences in the graphical symbols' performances between participant groups, which otherwise seemed to have similar levels of recognition. These are very valuable not only in determining the symbols to be retained, replaced or re-designed, but also in formulating instructions and other aids in learning to use new products faster and more satisfactorily.

HLYWD: a program for post-processing data files to generate selected plots or time-lapse graphics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Munro, J.K. Jr.

1980-05-01

The program HLYWD is a post-processor of output files generated by large plasma simulation computations or of data files containing a time sequence of plasma diagnostics. It is intended to be used in a production mode for either type of application; i.e., it allows one to generate along with the graphics sequence, segments containing title, credits to those who performed the work, text to describe the graphics, and acknowledgement of funding agency. The current version is designed to generate 3D plots and allows one to select type of display (linear or semi-log scales), choice of normalization of function values formore » display purposes, viewing perspective, and an option to allow continuous rotations of surfaces. This program was developed with the intention of being relatively easy to use, reasonably flexible, and requiring a minimum investment of the user's time. It uses the TV80 library of graphics software and ORDERLIB system software on the CDC 7600 at the National Magnetic Fusion Energy Computing Center at Lawrence Livermore Laboratory in California.« less

Demonstration of new PCSD capabilities

NASA Technical Reports Server (NTRS)

Gough, M.

1986-01-01

The new, more flexible and more friendly graphics capabilities to be available in later releases of the Pilot Climate Data System were demonstrated. The LIMS-LAMAT data set was chosen to illustrate these new capabilities. Pseudocolor and animation were used to represent the third and fourth dimensions, expanding the analytical capabilities available through the traditional two-dimensional x-y plot. In the new version, variables for the axes are chosen by scrolling through viable selections. This scrolling feature is a function of the new user interface customization. The new graphics are extremely user friendly and should free the scientist to look at data and converse with it, without doing any programming. The system is designed to rapidly plot any variable versus any other variable and animate by any variable. Any one plot in itself is not extraordinary; however, the fact that a user can generate the plots instead of a programmer distinguishes the graphics capabilities of the PCDS from other software packages. In addition, with the new CDF design, the system will become more generic, and the new graphics will become much more rigorous in the area of correlative studies.

Adaptive strength gains in dystrophic muscle exposed to repeated bouts of eccentric contraction

PubMed Central

Call, Jarrod A.; Eckhoff, Michael D.; Baltgalvis, Kristen A.; Warren, Gordon L.

2011-01-01

The objective of this study was to determine the functional recovery and adaptation of dystrophic muscle to multiple bouts of contraction-induced injury. Because lengthening (i.e., eccentric) contractions are extremely injurious for dystrophic muscle, it was considered that repeated bouts of such contractions would exacerbate the disease phenotype in mdx mice. Anterior crural muscles (tibialis anterior and extensor digitorum longus) and posterior crural muscles (gastrocnemius, soleus, and plantaris) from mdx mice performed one or five repeated bouts of 100 electrically stimulated eccentric contractions in vivo, and each bout was separated by 10–18 days. Functional recovery from one bout was achieved 7 days after injury, which was in contrast to a group of wild-type mice, which still showed a 25% decrement in electrically stimulated isometric torque at that time point. Across bouts there was no difference in the immediate loss of strength after repeated bouts of eccentric contractions for mdx mice (−70%, P = 0.68). However, after recovery from each bout, dystrophic muscle had greater torque-generating capacity such that isometric torque was increased ∼38% for both anterior and posterior crural muscles at bout 5 compared with bout 1 (P < 0.001). Moreover, isolated extensor digitorum longus muscles excised from in vivo-tested hindlimbs 14–18 days after bout 5 had greater specific force than contralateral control muscles (12.2 vs. 10.4 N/cm2, P = 0.005) and a 20% greater maximal relaxation rate (P = 0.049). Additional adaptations due to the multiple bouts of eccentric contractions included rapid recovery and/or sparing of contractile proteins, enhanced parvalbumin expression, and a decrease in fiber size variability. In conclusion, eccentric contractions are injurious to dystrophic skeletal muscle; however, the muscle recovers function rapidly and adapts to repeated bouts of eccentric contractions by improving strength. PMID:21960659

An education program about pelvic floor muscles improved women's knowledge but not pelvic floor muscle function, urinary incontinence or sexual function: a randomised trial.

PubMed

de Andrade, Roberta Leopoldino; Bø, Kari; Antonio, Flavia Ignácio; Driusso, Patricia; Mateus-Vasconcelos, Elaine Cristine Lemes; Ramos, Salvador; Julio, Monica Pitanguy; Ferreira, Cristine Homsi Jorge

2018-04-01

Does an educational program with instructions for performing 'the Knack' improve voluntary contraction of the pelvic floor muscles, reduce reports of urinary incontinence, improve sexual function, and promote women's knowledge of the pelvic floor muscles? Randomised, controlled trial with concealed allocation, intention-to-treat analysis and blinded assessors. Ninety-nine women from the local community. The experimental group (n=50) received one lecture per week for 4 weeks, and instructions for performing 'the Knack'. The control group (n=49) received no intervention. The primary outcome was maximum voluntary contraction of the pelvic floor muscles measured using manometry. Secondary outcomes were: ability to contract the pelvic floor muscles measured using vaginal palpation; severity of urinary incontinence measured by the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) scored from 0 to 21; self-reported sexual function; and knowledge related to the pelvic floor. Outcomes were measured at baseline and after 4 weeks. The intervention did not significantly improve: maximum voluntary contraction (MD 2.7 cmH 2 O higher in the experimental group, 95% CI -0.5 to 5.9); ability to contract the pelvic floor muscles (RR 2.18, 95% CI 0.49 to 9.65); or self-reported severity of urinary incontinence (MD 1 point greater reduction in the experimental group, 95% CI -3 to 1). Sexual function did not significantly differ between groups, but very few of the women engaged in sexual activity during the study period. The educational program did, however, significantly increase women's knowledge related to the location, functions and dysfunctions of the pelvic floor muscles, and treatment options. Education and teaching women to perform 'the Knack' had no significant effect on voluntary contraction of the pelvic floor muscles, urinary incontinence or sexual function, but it promoted women's knowledge about the pelvic floor. Brazilian Registry of Clinical Trials, RBR-95sxqv. [de Andrade RL, Bø K, Antonio FI, Driusso P, Mateus-Vasconcelos ECL, Ramos S, Julio MP, Ferreira CHJ (2018) An education program about pelvic floor muscles improved women's knowledge but not pelvic floor muscle function, urinary incontinence or sexual function: a randomised trial. Journal of Physiotherapy 64: 91-96]. Copyright © 2018 Australian Physiotherapy Association. Published by Elsevier B.V. All rights reserved.

Communication between functional and denervated muscles using radiofrequency.

PubMed

Jacob, Doreen K; Stefko, Susan Tonya; Hackworth, Steven A; Lovell, Michael R; Mickle, Marlin H

2006-05-01

This article focuses on establishing communication between a functional muscle and a denervated muscle using a radiofrequency communications link. The ultimate objective of the project is to restore the eye blink in patients with facial nerve paralysis. Two sets of experiments were conducted using the gastrocnemius leg muscles of Sprague-Dawley rats. In the initial tests, varying magnitudes of voltages ranging from 0.85 to 2.5 V were applied directly to a denervated muscle to determine the voltage required to produce visible contraction. The second set of experiments was then conducted to determine the voltage output from an in vivo muscle contraction that could be sensed and used to coordinate a signal for actuation of a muscle in a separate limb. After designing the appropriate external communication circuitry, a third experiment was performed to verify that a signal between a functional and a denervated muscle can be generated and used as a stimulus. Voltages below 2 V at a 10-millisecond pulse width elicited a gentle, controlled contraction of the denervated muscle in vivo. It was also observed that with longer pulse widths, higher stimulation voltages were required to produce sufficient contractions. It is possible to detect contraction of a muscle, use this to generate a signal to an external base station, and subsequently cause a separate, denervated muscle to contract in response to the signal. This demonstration in vivo of a signaling system for pacing of electrical stimulation of 1 muscle to spontaneous contraction of another, separate muscle, using radiofrequency communication without direct connection, may be used in numerous ways to overcome nerve damage.

Purinergic and cholinergic components of bladder contractility and flow.

PubMed

Theobald, R J

1995-01-01

The role of ATP as a neurotransmitter/neuromodulator in the urinary tract has been the subject of much study, particularly whether ATP has a functional role in producing urine flow. Recent studies suggested significant species variation, specifically a variation between cat and other species. This study was performed to determine the in vivo response of cat urinary bladder to pelvic nerve stimulation (PNS) and to the exogenous administration of cholinergic and purinergic agents. In anesthetized cats, bladder contractions and fluid expulsion was measured in response to PNS and to the exogenous administration of cholinergic and purinergic agents. Fluid was instilled into the bladder and any fluid expelled by bladder contractions induced by PNS or exogenous agents was collected in a beaker. The volume was measured in a graduated cylinder and recorded. PNS, carbachol and APPCP produced sustained contractions with significant expulsion of fluid. ATP, ACh and hypogastric nerve stimulation did not produce any significant expulsion of fluid. Atropine, a cholinergic antagonist, inhibited PNS contractions and fluid expulsion with no effect on purinergic actions. There was a significant relationship between the magnitude of the contraction, duration of the contractions and volume of fluid expelled. The data and information from other studies, strongly suggests a functional role for ATP as a cotransmitter in the lower urinary tract different from ACh's role. ATP stimulation of a specific purinergic receptor plays a role in initiation of bladder contractions and perhaps in the initiation of urine flow from the bladder. ACh's role is functionally different and appears to be more involved in maintenance of contractile activity and flow.

Processes and Reasoning in Representations of Linear Functions

ERIC Educational Resources Information Center

Adu-Gyamfi, Kwaku; Bossé, Michael J.

2014-01-01

This study examined student actions, interpretations, and language in respect to questions raised regarding tabular, graphical, and algebraic representations in the context of functions. The purpose was to investigate students' interpretations and specific ways of working within table, graph, and the algebraic on notions fundamental to a…

Investigating Functions Using Real-World Data

ERIC Educational Resources Information Center

Arnold, Stephen

2006-01-01

The possibilities for using graphic calculators to enhance the teaching and learning of mathematics are great. However, the boundaries explode when these powerful tools for learning are connected to data logging devices: a whole new approach to mathematics learning becomes possible. Using real world data to introduce the main functions (which are…

Data Bases and Libraries.

ERIC Educational Resources Information Center

Cote, L. G.

A system in which the function of the library is to acquire, store, and organize materials is proposed which separates the reference function into a group of subject specialists backed up by computerized information retrieval systems. This division of labor is caused by the scientific community's need for access to graphic and other specific (not…

Quick estimate of oil discovery from gas-condensate reservoirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sarem, A.M.

1966-10-24

A quick method of estimating the depletion performance of gas-condensate reservoirs is presented by graphical representations. The method is based on correlations reported in the literature and expresses recoverable liquid as function of gas reserves, producing gas-oil ratio, and initial and final reservoir pressures. The amount of recoverable liquid reserves (RLR) under depletion conditions, is estimated from an equation which is given. Where the liquid-reserves are in stock-tank barrels the gas reserves are in Mcf, with the arbitrary constant, N calculated from one graphical representation by dividing fractional oil recovery by the initial gas-oil ratio and multiplying 10U6D for convenience.more » An equation is given for estimating the coefficient C. These factors (N and C) can be determined from the graphical representations. An example calculation is included.« less

Flight Telerobotic Servicer prototype simulator

NASA Astrophysics Data System (ADS)

Schein, Rob; Krauze, Linda; Hartley, Craig; Dickenson, Alan; Lavecchia, Tom; Working, Bob

A prototype simulator for the Flight Telerobotic Servicer (FTS) system is described for use in the design development of the FTS, emphasizing the hand controller and user interface. The simulator utilizes a graphics workstation based on rapid prototyping tools for systems analyses of the use of the user interface and the hand controller. Kinematic modeling, manipulator-control algorithms, and communications programs are contained in the software for the simulator. The hardwired FTS panels and operator interface for use on the STS Orbiter are represented graphically, and the simulated controls function as the final FTS system configuration does. The robotic arm moves based on the user hand-controller interface, and the joint angles and other data are given on the prototype of the user interface. This graphics simulation tool provides the means for familiarizing crewmembers with the FTS system operation, displays, and controls.

The impact of aided language stimulation on symbol comprehension and production in children with moderate cognitive disabilities.

PubMed

Harris, Michael D; Reichle, Joe

2004-05-01

Over the past decade, aided language stimulation has emerged as a strategy to promote both symbol comprehension and symbol production among individuals who use graphic mode communication systems. During aided language stimulation, an interventionist points to a graphic symbol while simultaneously producing the corresponding spoken word during natural communicative exchanges. The purpose of this study was to determine the impact of aided language stimulation on children with moderate cognitive disabilities. Three preschool children with moderate cognitive disabilities who were functionally nonspeaking participated in the investigation. The investigator implemented a multiple-probe design across symbol sets/activities. Elicited probes were used to determine whether the children increased their comprehension and production of graphic symbols. Results indicated that all 3 children displayed increased symbol comprehension and production following the implementation of aided language stimulation.

Graphics enhanced computer emulation for improved timing-race and fault tolerance control system analysis. [of Centaur liquid-fuel booster

NASA Technical Reports Server (NTRS)

Szatkowski, G. P.

1983-01-01

A computer simulation system has been developed for the Space Shuttle's advanced Centaur liquid fuel booster rocket, in order to conduct systems safety verification and flight operations training. This simulation utility is designed to analyze functional system behavior by integrating control avionics with mechanical and fluid elements, and is able to emulate any system operation, from simple relay logic to complex VLSI components, with wire-by-wire detail. A novel graphics data entry system offers a pseudo-wire wrap data base that can be easily updated. Visual subsystem operations can be selected and displayed in color on a six-monitor graphics processor. System timing and fault verification analyses are conducted by injecting component fault modes and min/max timing delays, and then observing system operation through a red line monitor.

Nearly Interactive Parabolized Navier-Stokes Solver for High Speed Forebody and Inlet Flows

NASA Technical Reports Server (NTRS)

Benson, Thomas J.; Liou, May-Fun; Jones, William H.; Trefny, Charles J.

2009-01-01

A system of computer programs is being developed for the preliminary design of high speed inlets and forebodies. The system comprises four functions: geometry definition, flow grid generation, flow solver, and graphics post-processor. The system runs on a dedicated personal computer using the Windows operating system and is controlled by graphical user interfaces written in MATLAB (The Mathworks, Inc.). The flow solver uses the Parabolized Navier-Stokes equations to compute millions of mesh points in several minutes. Sample two-dimensional and three-dimensional calculations are demonstrated in the paper.

Semantics by analogy for illustrative volume visualization☆

PubMed Central

Gerl, Moritz; Rautek, Peter; Isenberg, Tobias; Gröller, Eduard

2012-01-01

We present an interactive graphical approach for the explicit specification of semantics for volume visualization. This explicit and graphical specification of semantics for volumetric features allows us to visually assign meaning to both input and output parameters of the visualization mapping. This is in contrast to the implicit way of specifying semantics using transfer functions. In particular, we demonstrate how to realize a dynamic specification of semantics which allows to flexibly explore a wide range of mappings. Our approach is based on three concepts. First, we use semantic shader augmentation to automatically add rule-based rendering functionality to static visualization mappings in a shader program, while preserving the visual abstraction that the initial shader encodes. With this technique we extend recent developments that define a mapping between data attributes and visual attributes with rules, which are evaluated using fuzzy logic. Second, we let users define the semantics by analogy through brushing on renderings of the data attributes of interest. Third, the rules are specified graphically in an interface that provides visual clues for potential modifications. Together, the presented methods offer a high degree of freedom in the specification and exploration of rule-based mappings and avoid the limitations of a linguistic rule formulation. PMID:23576827

Requirements management and control

NASA Technical Reports Server (NTRS)

Robbins, Red

1993-01-01

The systems engineering process for thermal nuclear propulsion requirements and configuration definition is described in outline and graphic form. Functional analysis and mission attributes for a Mars exploration mission are also addressed.

What Does a Graphical Representation Mean for Students at the Beginning of Function Teaching?

ERIC Educational Resources Information Center

Yavuz, Ilyas

2010-01-01

This study examines how students in the early stages of learning about the concept of functions, describe a curve and, in particular, evaluate the appropriateness of their argument about the representation of a function. Students are offered a message game which is related to a curve drawn on a coordinate system, representing an "imaginary…

Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds.

PubMed

Radisic, Milica; Park, Hyoungshin; Shing, Helen; Consi, Thomas; Schoen, Frederick J; Langer, Robert; Freed, Lisa E; Vunjak-Novakovic, Gordana

2004-12-28

The major challenge of tissue engineering is directing the cells to establish the physiological structure and function of the tissue being replaced across different hierarchical scales. To engineer myocardium, biophysical regulation of the cells needs to recapitulate multiple signals present in the native heart. We hypothesized that excitation-contraction coupling, critical for the development and function of a normal heart, determines the development and function of engineered myocardium. To induce synchronous contractions of cultured cardiac constructs, we applied electrical signals designed to mimic those in the native heart. Over only 8 days in vitro, electrical field stimulation induced cell alignment and coupling, increased the amplitude of synchronous construct contractions by a factor of 7, and resulted in a remarkable level of ultrastructural organization. Development of conductive and contractile properties of cardiac constructs was concurrent, with strong dependence on the initiation and duration of electrical stimulation.

Interactive dual-volume rendering visualization with real-time fusion and transfer function enhancement

NASA Astrophysics Data System (ADS)

Macready, Hugh; Kim, Jinman; Feng, David; Cai, Weidong

2006-03-01

Dual-modality imaging scanners combining functional PET and anatomical CT constitute a challenge in volumetric visualization that can be limited by the high computational demand and expense. This study aims at providing physicians with multi-dimensional visualization tools, in order to navigate and manipulate the data running on a consumer PC. We have maximized the utilization of pixel-shader architecture of the low-cost graphic hardware and the texture-based volume rendering to provide visualization tools with high degree of interactivity. All the software was developed using OpenGL and Silicon Graphics Inc. Volumizer, tested on a Pentium mobile CPU on a PC notebook with 64M graphic memory. We render the individual modalities separately, and performing real-time per-voxel fusion. We designed a novel "alpha-spike" transfer function to interactively identify structure of interest from volume rendering of PET/CT. This works by assigning a non-linear opacity to the voxels, thus, allowing the physician to selectively eliminate or reveal information from the PET/CT volumes. As the PET and CT are rendered independently, manipulations can be applied to individual volumes, for instance, the application of transfer function to CT to reveal the lung boundary while adjusting the fusion ration between the CT and PET to enhance the contrast of a tumour region, with the resultant manipulated data sets fused together in real-time as the adjustments are made. In addition to conventional navigation and manipulation tools, such as scaling, LUT, volume slicing, and others, our strategy permits efficient visualization of PET/CT volume rendering which can potentially aid in interpretation and diagnosis.

Transforming Wartime Contracting: Controlling Costs, Reducing Risks

DTIC Science & Technology

2011-08-01

reduce the risk of awarding contracts to companies with questionable capability to perform. Expansion of investigative authority and jurisdiction ...A forcing function is needed to ensure widespread and effective adoption of contingency-contracting reform. Otherwise, agency inertia , resistance to...inflamed because jurisdiction over contractors is ambiguous, legal accountability is uncertain, and a clear command-and-control structure is absent. A

Contracting Deployment Customer Guide.

DTIC Science & Technology

1996-12-01

functional managers from the major commands expressed the need to develop a Customer Guide for contingency deployments which would standardize, simplify, and...streamline the support our Contingency Contracting Officers (CCOs) provide to our customers .

PCBs Alter Dopamine Mediated Function in Aging Workers

DTIC Science & Technology

2008-01-01

in Aging Workers PRINCIPAL INVESTIGATOR: Richard F. Seegal, Ph.D. CONTRACTING ORGANIZATION: Health Research Incorporated... Health Perspectives, describes the associations between serum PCB concentrations and occupational exposure as well as fish consumption; the senior author...Alter Dopamine Mediated Function in Aging Workers 5a. CONTRACT NUMBER 5b. GRANT NUMBER DAMD17-02-1-0173 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR

C-class functions with new approach on coincidence point results for generalized [Formula: see text]-weakly contractions in ordered b-metric spaces.

PubMed

Mustafa, Zead; Jaradat, Mohammed M M; Ansari, Arslan Hojat; Popović, Branislav Z; Jaradat, Husein M

2016-01-01

In this paper, by using the C-class functions and a new approach we present some coincidence point results for four mappings satisfying generalized [Formula: see text]-weakly contractive condition in the setting of ordered b-metric spaces. Also, an application and example are given to support our results.

Motor and sensory function of the esophagus: revelations through ultrasound imaging.

PubMed

Mittal, Ravinder K

2005-04-01

Catheter based high frequency intraluminal ultrasound (HFIUS) imaging is a powerful tool to study esophageal sensory and motor function and dysfunction in vivo in humans. It has provided a number of important insights into the longitudinal muscle function of the esophagus. Based on the ultrasound images and intraluminal pressure recordings, it is clear that there is synchrony in the timing as well as the amplitude of contraction between the circular and the longitudinal muscle layers of the esophagus in normal subjects. On the other hand, in patients with spastic disorders of the esophagus, there is an asynchrony of contraction related to the timing and amplitude of contraction of the two muscle layers during peristalsis. Achalasia, diffuse esophageal spasm, and nutcracker esophagus (spastic motor disorders of the esophagus) are associated with hypertrophy of the circular as well as longitudinal muscle layers. A sustained contraction of the longitudinal muscle of the esophagus is temporally related to chest pain and heartburn and may very well be the cause of symptoms. Longitudinal muscle function of the esophagus can be studied in vivo in humans using dynamic ultrasound imaging. Longitudinal muscle dysfunction appears to be important in the motor and sensory disorders of the esophagus.

Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.

PubMed

Butkevich, Eugenia; Bodensiek, Kai; Fakhri, Nikta; von Roden, Kerstin; Schaap, Iwan A T; Majoul, Irina; Schmidt, Christoph F; Klopfenstein, Dieter R

2015-07-06

Actin filament organization and stability in the sarcomeres of muscle cells are critical for force generation. Here we identify and functionally characterize a Caenorhabditis elegans drebrin-like protein DBN-1 as a novel constituent of the muscle contraction machinery. In vitro, DBN-1 exhibits actin filament binding and bundling activity. In vivo, DBN-1 is expressed in body wall muscles of C. elegans. During the muscle contraction cycle, DBN-1 alternates location between myosin- and actin-rich regions of the sarcomere. In contracted muscle, DBN-1 is accumulated at I-bands where it likely regulates proper spacing of α-actinin and tropomyosin and protects actin filaments from the interaction with ADF/cofilin. DBN-1 loss of function results in the partial depolymerization of F-actin during muscle contraction. Taken together, our data show that DBN-1 organizes the muscle contractile apparatus maintaining the spatial relationship between actin-binding proteins such as α-actinin, tropomyosin and ADF/cofilin and possibly strengthening actin filaments by bundling.

Relationship between aerobic capacity and pelvic floor muscles function: a cross-sectional study

PubMed Central

Jürgensen, S.P.; Borghi-Silva, A.; Bastos, A.M.F.G.; Correia, G.N.; Pereira-Baldon, V.S.; Cabiddu, R.; Catai, A.M.; Driusso, P.

2017-01-01

The objective of this study was to evaluate the relationship between aerobic capacity and pelvic floor muscles (PFM) function in adult women. Women aged 18 or over and without urinary dysfunction or other chronic diseases were eligible to participate. They completed the habitual physical activity (HPA) questionnaire, underwent a PFM functional evaluation by palpation and perineometry, and performed a submaximal (between 75 and 85% of maximum heart rate) cardiopulmonary exercise (CPX) test to determine the ventilatory anaerobic threshold (VAT). Forty-one women were included (35±16 years, 75% physically active, 17% very active, and 8% sedentary and 17% presented grade 1 PFM contraction, 31.8% grade 2, 26.8% grade 3, and 24.4% grade 4, according to the modified Oxford Scale). The average PFM contraction pressure obtained by perineometer was 53±26 cmH2O and the average oxygen consumption at VAT (VO2VAT) obtained from CPX was 14±2 mL·kg-1·min-1. Significant correlations were found between PFM contraction pressure and VO2VAT (r=0.55; P<0.001); between PFM contraction pressure and HPA score (r=0.38; P=0.02); between age and VO2VAT (r=-0.25; P=0.049); and between VO2VAT and HPA score (r=0.36; P=0.02). An age-adjusted multiple linear regression equation (R2=0.32) was derived to estimate VO2VAT from the contraction value obtained by perineometer, so that the PFM contraction pressure was able to predict VO2VAT. The equation was validated using data from another group of 20 healthy women (33±12 years; PFM contraction: 49±23 cmH2O) and no significant difference was found between actual VO2VAT and predicted VO2VAT (13.1±1.9 vs 13.8±2.0 mL·kg-1·min-1). In conclusion, PFM function is associated with aerobic capacity in healthy women and PFM contraction pressure may be used to estimate VO2VAT in this population. PMID:28953985

Mesenchymal stromal cells reverse hypoxia-mediated suppression of α-smooth muscle actin expression in human dermal fibroblasts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faulknor, Renea A.; Olekson, Melissa A.; Nativ, Nir I.

During wound healing, fibroblasts deposit extracellular matrix that guides angiogenesis and supports the migration and proliferation of cells that eventually form the scar. They also promote wound closure via differentiation into α-smooth muscle actin (SMA)-expressing myofibroblasts, which cause wound contraction. Low oxygen tension typical of chronic nonhealing wounds inhibits fibroblast collagen production and differentiation. It has been suggested that hypoxic mesenchymal stromal cells (MSCs) secrete factors that promote wound healing in animal models; however, it is unclear whether these factors are equally effective on the target cells in a hypoxic wound environment. Here we investigated the impact of MSC-derived solublemore » factors on the function of fibroblasts cultured in hypoxic fibroblast-populated collagen lattices (FPCLs). Hypoxia alone significantly decreased FPCL contraction and α-SMA expression. MSC-conditioned medium restored hypoxic FPCL contraction and α-SMA expression to levels similar to normoxic FPCLs. (SB431542), an inhibitor of transforming growth factor-β{sub 1} (TGF-β{sub 1})-mediated signaling, blocked most of the MSC effect on FPCL contraction, while exogenous TGF-β{sub 1} at levels similar to that secreted by MSCs reproduced the MSC effect. These results suggest that TGF-β{sub 1} is a major paracrine signal secreted by MSCs that can restore fibroblast functions relevant to the wound healing process and that are impaired in hypoxia. - Highlights: • Fibroblasts were cultured in collagen lattices (FPCLs) as model contracting wounds. • Hypoxia decreased FPCL contraction and fibroblast α-smooth muscle actin expression. • Mesenchymal stromal cells (MSCs) restored function of hypoxic fibroblasts. • MSCs regulate fibroblast function mainly via secreted transforming growth factor-β{sub 1}.« less

Telemetry Monitoring and Display Using LabVIEW

NASA Technical Reports Server (NTRS)

Wells, George; Baroth, Edmund C.

1993-01-01

The Measurement Technology Center of the Instrumentation Section configures automated data acquisition systems to meet the diverse needs of JPL's experimental research community. These systems are based on personal computers or workstations (Apple, IBM/Compatible, Hewlett-Packard, and Sun Microsystems) and often include integrated data analysis, visualization and experiment control functions in addition to data acquisition capabilities. These integrated systems may include sensors, signal conditioning, data acquisition interface cards, software, and a user interface. Graphical programming is used to simplify configuration of such systems. Employment of a graphical programming language is the most important factor in enabling the implementation of data acquisition, analysis, display and visualization systems at low cost. Other important factors are the use of commercial software packages and off-the-shelf data acquisition hardware where possible. Understanding the experimenter's needs is also critical. An interactive approach to user interface construction and training of operators is also important. One application was created as a result of a competative effort between a graphical programming language team and a text-based C language programming team to verify the advantages of using a graphical programming language approach. With approximately eight weeks of funding over a period of three months, the text-based programming team accomplished about 10% of the basic requirements, while the Macintosh/LabVIEW team accomplished about 150%, having gone beyond the original requirements to simulate a telemetry stream and provide utility programs. This application verified that using graphical programming can significantly reduce software development time. As a result of this initial effort, additional follow-on work was awarded to the graphical programming team.

Emotional reaction facilitates the brain and behavioral impact of graphic cigarette warning labels in smokers

PubMed Central

Wang, An-Li; Lowen, Steven B; Romer, Daniel; Giorno, Mario; Langleben, Daniel D

2015-01-01

Background Warning labels on cigarette packages are an important venue for information about the hazards of smoking. The 2009 US Family Smoking Prevention and Tobacco Control Act mandated replacing the current text-only labels with graphic warning labels. However, labels proposed by the Food and Drug Administration (FDA) were challenged in court by the tobacco companies, who argued successfully that the proposed labels needlessly encroached on their right to free speech, in part because they included images of high emotional salience that indiscriminately frightened rather than informed consumers. Methods We used functional MRI to examine the effects of graphic warning labels' emotional salience on smokers' brain activity and cognition. Twenty-four smokers viewed a random sequence of blocks of graphic warning labels that have been rated high or low on an ‘emotional reaction’ scale in previous research. Results We found that labels rated high on emotional reaction were better remembered, associated with reduction in the urge to smoke, and produced greater brain response in the amygdala, hippocampi, inferior frontal gyri and the insulae. Conclusions Recognition memory and craving are, respectively, correlates of effectiveness of addiction related public health communications and interventions, and amygdala activation facilitates the encoding of emotional memories. Thus, our results suggest that emotional reaction to graphic warning labels contributes to their public health impact and may be an integral part of the neural mechanisms underlying their effectiveness. Given the urgency of the debate about the constitutional risks and public health benefits of graphic warning labels, these preliminary findings warrant consideration while longitudinal clinical studies are underway PMID:25564288

48 CFR 37.102 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... performance of an inherently governmental function (see subpart 7.5). (d) Non-personal service contracts are... describing the need to be filled, or problem to be resolved, through service contracting in a manner that...

48 CFR 37.102 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... performance of an inherently governmental function (see subpart 7.5). (d) Non-personal service contracts are... describing the need to be filled, or problem to be resolved, through service contracting in a manner that...

Integration of Genomic, Biologic, and Chemical Approaches to Target p53 Loss and Gain-of-Function in Triple Negative Breast Cancer

DTIC Science & Technology

2015-09-01

dissertation research is determining the mechanism and “targetability” of a mutant p53-adapted state in triple-negative breast cancer . Tim’s...Negative Breast Cancer PRINCIPAL INVESTIGATOR: Jennifer A. Pietenpol, Ph.D. CONTRACTING ORGANIZATION: The Vanderbilt University Nashville, TN...Loss and Gain-of-Function in Triple Negative Breast Cancer 5a. CONTRACT NUMBER W81XWH-13-1-0287 p53 Loss and Gain-of-Function in Triple Negative

GKS. Minimal Graphical Kernel System C Binding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simons, R.W.

1985-10-01

GKS (the Graphical Kernel System) is both an American National Standard (ANS) and an ISO international standard graphics package. It conforms to ANS X3.124-1985 and to the May 1985 draft proposal for the GKS C Language Binding standard under development by the X3H3 Technical Committee. This implementation includes level ma (the lowest level of the ANS) and some routines from level mb. The following graphics capabilities are supported: two-dimensional lines, markers, text, and filled areas; control over color, line type, and character height and alignment; multiple simultaneous workstations and multiple transformations; and locator and choice input. Tektronix 4014 and 4115more » terminals are supported, and support for other devices may be added. Since this implementation was developed under UNIX, it uses makefiles, C shell scripts, the ar library maintainer, editor scripts, and other UNIX utilities. Therefore, implementing it under another operating system may require considerable effort. Also included with GKS is the small plot package (SPP), a direct descendant of the WEASEL plot package developed at Sandia. SPP is built on the GKS; therefore, all of the capabilities of GKS are available. It is not necessary to use GKS functions, since entire plots can be produced using only SPP functions, but the addition of GKS will give the programmer added power and flexibility. SPP provides single-call plot commands, linear and logarithmic axis commands, control for optional plotting of tick marks and tick mark labels, and permits plotting of data with or without markers and connecting lines.« less

GProX, a user-friendly platform for bioinformatics analysis and visualization of quantitative proteomics data.

PubMed

Rigbolt, Kristoffer T G; Vanselow, Jens T; Blagoev, Blagoy

2011-08-01

Recent technological advances have made it possible to identify and quantify thousands of proteins in a single proteomics experiment. As a result of these developments, the analysis of data has become the bottleneck of proteomics experiment. To provide the proteomics community with a user-friendly platform for comprehensive analysis, inspection and visualization of quantitative proteomics data we developed the Graphical Proteomics Data Explorer (GProX)(1). The program requires no special bioinformatics training, as all functions of GProX are accessible within its graphical user-friendly interface which will be intuitive to most users. Basic features facilitate the uncomplicated management and organization of large data sets and complex experimental setups as well as the inspection and graphical plotting of quantitative data. These are complemented by readily available high-level analysis options such as database querying, clustering based on abundance ratios, feature enrichment tests for e.g. GO terms and pathway analysis tools. A number of plotting options for visualization of quantitative proteomics data is available and most analysis functions in GProX create customizable high quality graphical displays in both vector and bitmap formats. The generic import requirements allow data originating from essentially all mass spectrometry platforms, quantitation strategies and software to be analyzed in the program. GProX represents a powerful approach to proteomics data analysis providing proteomics experimenters with a toolbox for bioinformatics analysis of quantitative proteomics data. The program is released as open-source and can be freely downloaded from the project webpage at http://gprox.sourceforge.net.

GProX, a User-Friendly Platform for Bioinformatics Analysis and Visualization of Quantitative Proteomics Data*

PubMed Central

Rigbolt, Kristoffer T. G.; Vanselow, Jens T.; Blagoev, Blagoy

2011-01-01

Recent technological advances have made it possible to identify and quantify thousands of proteins in a single proteomics experiment. As a result of these developments, the analysis of data has become the bottleneck of proteomics experiment. To provide the proteomics community with a user-friendly platform for comprehensive analysis, inspection and visualization of quantitative proteomics data we developed the Graphical Proteomics Data Explorer (GProX)1. The program requires no special bioinformatics training, as all functions of GProX are accessible within its graphical user-friendly interface which will be intuitive to most users. Basic features facilitate the uncomplicated management and organization of large data sets and complex experimental setups as well as the inspection and graphical plotting of quantitative data. These are complemented by readily available high-level analysis options such as database querying, clustering based on abundance ratios, feature enrichment tests for e.g. GO terms and pathway analysis tools. A number of plotting options for visualization of quantitative proteomics data is available and most analysis functions in GProX create customizable high quality graphical displays in both vector and bitmap formats. The generic import requirements allow data originating from essentially all mass spectrometry platforms, quantitation strategies and software to be analyzed in the program. GProX represents a powerful approach to proteomics data analysis providing proteomics experimenters with a toolbox for bioinformatics analysis of quantitative proteomics data. The program is released as open-source and can be freely downloaded from the project webpage at http://gprox.sourceforge.net. PMID:21602510

Pre- and postprocessing for reservoir simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rogers, W.L.; Ingalls, L.J.; Prasad, S.J.

1991-05-01

This paper describes the functionality and underlying programing paradigms of Shell's simulator-related reservoir-engineering graphics system. THis system includes the simulation postprocessing programs Reservoir Display System (RDS) and Fast Reservoir Engineering Displays (FRED), a hypertext-like on-line documentation system (DOC), and a simulator input preprocessor (SIMPLSIM). RDS creates displays of reservoir simulation results. These displays represent the areal or cross-section distribution of computer reservoir parameters, such as pressure, phase saturation, or temperature. Generation of these images at real-time animation rates is discussed. FRED facilitates the creation of plot files from reservoir simulation output. The use of dynamic memory allocation, asynchronous I/O, amore » table-driven screen manager, and mixed-language (FORTRAN and C) programming are detailed. DOC is used to create and access on-line documentation for the pre-and post-processing programs and the reservoir simulators. DOC can be run by itself or can be accessed from within any other graphics or nongraphics application program. DOC includes a text editor, which is that basis for a reservoir simulation tutorial and greatly simplifies the preparation of simulator input. The use of sharable images, graphics, and the documentation file network are described. Finally, SIMPLSIM is a suite of program that uses interactive graphics in the preparation of reservoir description data for input into reservoir simulators. The SIMPLSIM user-interface manager (UIM) and its graphic interface for reservoir description are discussed.« less

Stroke-Related Changes in Neuromuscular Fatigue of the Hip Flexors and Functional Implications

PubMed Central

Hyngstrom, Allison S.; Onushko, Tanya; Heitz, Robert P.; Rutkowski, Anthony; Hunter, Sandra K.; Schmit, Brian D.

2014-01-01

Objective To compare stroke-related changes in hip-flexor neuromuscular fatigue of the paretic leg during a sustained, isometric sub-maximal contraction with the non-paretic leg and controls, and correlate fatigue with clinical measures of function. Design Hip torques were measured during a fatiguing hip-flexion contraction at 20% of the hip flexion maximal voluntary contraction (MVC) in the paretic and non-paretic legs of 13 people with chronic stroke and 10 age-matched controls. In addition, participants with stroke performed a fatiguing contraction of the paretic leg at the absolute torque equivalent to 20% MVC of the non-paretic leg and were tested for self-selected walking speed (Ten-Meter Walk Test) and balance (Berg). Results When matching the non-paretic target torque, the paretic hip flexors had a shorter time to task failure compared with the non-paretic leg and controls (p<0.05). Time to failure of the paretic leg was inversely correlated with the reduction of hip flexion MVC torque. Self-selected walking speed was correlated with declines in torque and steadiness. Berg-Balance scores were inversely correlated with the force fluctuation amplitude. Conclusions Fatigue and precision of contraction are correlated with walking function and balance post stroke. PMID:22157434

Applying Cognitive Work Analysis to Time Critical Targeting Functionality

DTIC Science & Technology

2004-10-01

Cognitive Task Analysis , CTA, Cognitive Task Analysis , Human Factors, GUI, Graphical User Interface, Heuristic Evaluation... Cognitive Task Analysis MITRE Briefing January 2000 Dynamic Battle Management Functional Architecture 3-1 Section 3 Human Factors...clear distinction between Cognitive Work Analysis (CWA) and Cognitive Task Analysis (CTA), therefore this document will refer to these

A Developmental Study of Concepts of Body Functioning. Final Report.

ERIC Educational Resources Information Center

Stern, Virginia; Zimiles, Herbert

The first phase of a projected research program aimed at examining children's ideas about body functioning, this study focuses on concepts of digestion, elimination of waste and assimilation of food held by children of different ages. (Subjects expressed these concepts both verbally and graphically). Possible cues to the influence of affect on…

Fonctions Discursives et Communication Ecrite (Discursive Functions and Written Communication). Melanges Pedagogiques, 1974.

ERIC Educational Resources Information Center

Duda, R.

This article describes discursive functions in the three major areas of non-literary written communication: (1) official or personal correspondence; (2) technical reading or editing; and (3) the press. Illocutionary acts are examined under their three aspects: graphic, lexical, enunciative. This description is intended to result in training…

Maple (Computer Algebra System) in Teaching Pre-Calculus: Example of Absolute Value Function

ERIC Educational Resources Information Center

Tuluk, Güler

2014-01-01

Modules in Computer Algebra Systems (CAS) make Mathematics interesting and easy to understand. The present study focused on the implementation of the algebraic, tabular (numerical), and graphical approaches used for the construction of the concept of absolute value function in teaching mathematical content knowledge along with Maple 9. The study…

Functional implications of muscle co-contraction during gait in advanced age.

PubMed

Lo, Justine; Lo, On-Yee; Olson, Erin A; Habtemariam, Daniel; Iloputaife, Ikechukwu; Gagnon, Margaret M; Manor, Brad; Lipsitz, Lewis A

2017-03-01

Older adults often exhibit high levels of lower extremity muscle co-contraction, which may be the cause or effect of age-related impairments in gait and associated falls. Normal gait requires intact executive function and thus can be slowed by challenging executive resources available to the neuromuscular system through the performance of a dual task. We therefore investigated associations between lower limb co-contraction and gait characteristics under normal and dual task conditions in healthy older adults (85.4±5.9years). We hypothesized that greater co-contraction is associated with slower gait speed during dual task conditions that stress executive and attentional abilities. Co-contraction was quantified during different phases of the gait cycle using surface electromyography (EMG) signals obtained from the anterior tibialis and lateral gastrocnemius while walking at preferred speed during normal and dual task conditions. Variables included the time difference to complete the Trail Making Test A and B (ΔTMT) and gait measures during normal or dual task walking. Higher co-contraction levels during the swing phase of both normal and dual task walking were associated with longer ΔTMT (normal: R 2 =0.25, p=0.02; dual task: R 2 =0.27, p=0.01). Co-contraction was associated with gait measures during dual task walking only; greater co-contraction levels during stride and stance were associated with slower gait speed (stride: R 2 =0.38, p=0.04; stance: R 2 =0.38, p=0.04), and greater co-contraction during stride was associated with longer stride time (R 2 =0.16, p=0.03). Our results suggest that relatively high lower limb co-contraction may explain some of the mobility impairments associated with the conduct of executive tasks in older adults. Copyright © 2017 Elsevier B.V. All rights reserved.

Wartime Construction Project Outcomes as a Function of Contract Type

DTIC Science & Technology

2016-07-01

contract types has been well established. The theory of contractual incentives promulgated by Sherer (1964) established expected contractor...behaviors using a max- imization problem. The theory focuses on expected contractor behaviors in incentive contracts (cf. Federal Acquisition Regulation...Scherer, F. M. (1964). The theory of contractual incentives for cost reduction. Quarterly Journal of Economics, 78, 257–280. Tawazuh Commercial and

Bioengineered intestinal muscularis complexes with long-term spontaneous and periodic contractions

PubMed Central

Wang, Qianqian; Wang, Ke; Solorzano-Vargas, R. Sergio; Lin, Po-Yu; Walthers, Christopher M.; Thomas, Anne-Laure; Martín, Martín G.

2018-01-01

Although critical for studies of gut motility and intestinal regeneration, the in vitro culture of intestinal muscularis with peristaltic function remains a significant challenge. Periodic contractions of intestinal muscularis result from the coordinated activity of smooth muscle cells (SMC), the enteric nervous system (ENS), and interstitial cells of Cajal (ICC). Reproducing this activity requires the preservation of all these cells in one system. Here we report the first serum-free culture methodology that consistently maintains spontaneous and periodic contractions of murine and human intestinal muscularis cells for months. In this system, SMC expressed the mature marker myosin heavy chain, and multipolar/dipolar ICC, uniaxonal/multipolar neurons and glial cells were present. Furthermore, drugs affecting neural signals, ICC or SMC altered the contractions. Combining this method with scaffolds, contracting cell sheets were formed with organized architecture. With the addition of intestinal epithelial cells, this platform enabled up to 11 types of cells from mucosa, muscularis and serosa to coexist and epithelial cells were stretched by the contracting muscularis cells. The method constitutes a powerful tool for mechanistic studies of gut motility disorders and the functional regeneration of the engineered intestine. PMID:29718926

New concept of the contraction-extension property of the left ventricular myocardium.

PubMed

Tanaka, Motonao; Sakamoto, Tsuguya; Sugawara, Shigeo; Katahira, Yoshiaki; Tabuchi, Haruna; Nakajima, Hiroyuki; Kurokawa, Takafumi; Kanai, Hiroshi; Hasegawa, Hideyuki; Ohtsuki, Shigeo

2014-04-01

Using newly developed ultrasonic technology, we attempted to disclose the characteristics of the left ventricular (LV) contraction-extension (C-E) property, which has an important relationship to LV function. Strain rate (SR) distribution within the posterior wall and interventricular septum was microscopically measured with a high accuracy of 821μm in spatial resolution by using the phase difference tracking method. The subjects were 10 healthy men (aged 30-50 years). The time course of the SR distribution disclosed the characteristic C-E property, i.e. the contraction started from the apex and propagated toward the base on one hand, and from the epicardial side toward the endocardial side on the other hand. Therefore, the contraction of one area and the extension of another area simultaneously appeared through nearly the whole cardiac cycle, with the contracting part positively extending the latter part and vice versa. The time course of these propagations gave rise to the peristalsis and the bellows action of the LV wall, and both contributed to effective LV function. The LV contraction started coinciding in time with the P wave of the electrocardiogram, and the cardiac cycle was composed of 4 phases, including 2 types of transitional phase, as well as the ejection phase and slow filling phase. The sum of the measurement time duration of either the contraction or the extension process occupied nearly equal duration in normal conditions. The newly developed ultrasonic technology revealed that the SR distribution was important in evaluating the C-E property of the LV myocardium. The harmonious succession of the 4 cardiac phases newly identified seemed to be helpful in understanding the mechanism to keep long-lasting pump function of the LV. Copyright © 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

Teaching the Relevance of Mathematics in Information Technologies through Functional Programming in Secondary School

ERIC Educational Resources Information Center

Ruiz, Rosario Vera

2011-01-01

From the point of view of functional programming, a computational process to solve a problem is described as a mathematical function taking some arguments (corresponding to the data of the problem) and returning as a result its solution. Turtle Graphics can be used to describe the movements of a virtual turtle, which leaves a trail along his path…

Characterization of terrestrial solar cells for space applications: Electrical characteristics of thin Westinghouse dendritic web cells as a function of solar intensity, temperature, and incidence angle

NASA Technical Reports Server (NTRS)

Stella, P. M.; Anspaugh, B. E.

1985-01-01

Electrical characteristics of thin (100- and 140-micron) Westinghouse dendritic-web N/P silicon solar cells are presented in graphical and tabular format as a function of solar illumination intensity and temperature. Performance is also shown as a function of solar illlumination angle of incidence for AMO.

Recursive search method for the image elements of functionally defined surfaces

NASA Astrophysics Data System (ADS)

Vyatkin, S. I.

2017-05-01

This paper touches upon the synthesis of high-quality images in real time and the technique for specifying three-dimensional objects on the basis of perturbation functions. The recursive search method for the image elements of functionally defined objects with the use of graphics processing units is proposed. The advantages of such an approach over the frame-buffer visualization method are shown.

Energy Emergency Management Information System (EEMIS): Functional requirements

NASA Astrophysics Data System (ADS)

1980-10-01

These guidelines state that in order to create the widest practicable competition, the system's requirements, with few exceptions, must be expressed in functional terms without reference to specific hardware or software products, and that wherever exceptions are made a statement of justification must be provided. In addition, these guidelines set forth a recommended maximum threshold limit of annual contract value for schedule contract procurements.

Empirical comparison study of approximate methods for structure selection in binary graphical models.

PubMed

Viallon, Vivian; Banerjee, Onureena; Jougla, Eric; Rey, Grégoire; Coste, Joel

2014-03-01

Looking for associations among multiple variables is a topical issue in statistics due to the increasing amount of data encountered in biology, medicine, and many other domains involving statistical applications. Graphical models have recently gained popularity for this purpose in the statistical literature. In the binary case, however, exact inference is generally very slow or even intractable because of the form of the so-called log-partition function. In this paper, we review various approximate methods for structure selection in binary graphical models that have recently been proposed in the literature and compare them through an extensive simulation study. We also propose a modification of one existing method, that is shown to achieve good performance and to be generally very fast. We conclude with an application in which we search for associations among causes of death recorded on French death certificates. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AVE-SESAME program for the REEDA System

NASA Technical Reports Server (NTRS)

Hickey, J. S.

1981-01-01

The REEDA system software was modified and improved to process the AVE-SESAME severe storm data. A random access file system for the AVE storm data was designed, tested, and implemented. The AVE/SESAME software was modified to incorporate the random access file input and to interface with new graphics hardware/software now available on the REEDA system. Software was developed to graphically display the AVE/SESAME data in the convention normally used by severe storm researchers. Software was converted to AVE/SESAME software systems and interfaced with existing graphics hardware/software available on the REEDA System. Software documentation was provided for existing AVE/SESAME programs underlining functional flow charts and interacting questions. All AVE/SESAME data sets in random access format was processed to allow developed software to access the entire AVE/SESAME data base. The existing software was modified to allow for processing of different AVE/SESAME data set types including satellite surface and radar data.

EasyModeller: A graphical interface to MODELLER

PubMed Central

2010-01-01

Background MODELLER is a program for automated protein Homology Modeling. It is one of the most widely used tool for homology or comparative modeling of protein three-dimensional structures, but most users find it a bit difficult to start with MODELLER as it is command line based and requires knowledge of basic Python scripting to use it efficiently. Findings The study was designed with an aim to develop of "EasyModeller" tool as a frontend graphical interface to MODELLER using Perl/Tk, which can be used as a standalone tool in windows platform with MODELLER and Python preinstalled. It helps inexperienced users to perform modeling, assessment, visualization, and optimization of protein models in a simple and straightforward way. Conclusion EasyModeller provides a graphical straight forward interface and functions as a stand-alone tool which can be used in a standard personal computer with Microsoft Windows as the operating system. PMID:20712861

Payment contracts in a preventive health care system: a perspective from operations management.

PubMed

Yaesoubi, Reza; Roberts, Stephen D

2011-12-01

We consider a health care system consisting of two noncooperative parties: a health purchaser (payer) and a health provider, where the interaction between the two parties is governed by a payment contract. We determine the contracts that coordinate the health purchaser-health provider relationship; i.e. the contracts that maximize the population's welfare while allowing each entity to optimize its own objective function. We show that under certain conditions (1) when the number of customers for a preventive medical intervention is verifiable, there exists a gate-keeping contract and a set of concave piecewise linear contracts that coordinate the system, and (2) when the number of customers is not verifiable, there exists a contract of bounded linear form and a set of incentive-feasible concave piecewise linear contracts that coordinate the system. Copyright © 2011 Elsevier B.V. All rights reserved.

AMICAL: An aid for architectural synthesis and exploration of control circuits

NASA Astrophysics Data System (ADS)

Park, Inhag

AMICAL is an architectural synthesis system for control flow dominated circuits. A behavioral finite state machine specification, where the scheduling and register allocation were performed, is presented. An abstract architecture specification that may feed existing silicon compilers acting at the logic and register transfer levels is described. AMICAL consists of five main functions allowing automatic, interactive and manual synthesis, as well as the combination of these methods. These functions are a synthesizer, a graphics editor, a verifier, an evaluator, and a documentor. Automatic synthesis is achieved by algorithms that allocate both functional units, stored in an expandable user defined library, and connections. AMICAL also allows the designer to interrupt the synthesis process at any stage and make interactive modifications via a specially designed graphics editor. The user's modifications are verified and evaluated to ensure that no design rules are broken and that any imposed constraints are still met. A documentor provides the designer with status and feedback reports from the synthesis process.

High performance hybrid functional Petri net simulations of biological pathway models on CUDA.

PubMed

Chalkidis, Georgios; Nagasaki, Masao; Miyano, Satoru

2011-01-01

Hybrid functional Petri nets are a wide-spread tool for representing and simulating biological models. Due to their potential of providing virtual drug testing environments, biological simulations have a growing impact on pharmaceutical research. Continuous research advancements in biology and medicine lead to exponentially increasing simulation times, thus raising the demand for performance accelerations by efficient and inexpensive parallel computation solutions. Recent developments in the field of general-purpose computation on graphics processing units (GPGPU) enabled the scientific community to port a variety of compute intensive algorithms onto the graphics processing unit (GPU). This work presents the first scheme for mapping biological hybrid functional Petri net models, which can handle both discrete and continuous entities, onto compute unified device architecture (CUDA) enabled GPUs. GPU accelerated simulations are observed to run up to 18 times faster than sequential implementations. Simulating the cell boundary formation by Delta-Notch signaling on a CUDA enabled GPU results in a speedup of approximately 7x for a model containing 1,600 cells.

What's in a name? The role of graphics, functions, and their interrelationships in icon identification.

PubMed

McDougall, Siné; Isherwood, Sarah

2009-05-01

Communication using icons is now commonplace. It is therefore important to understand the processes involved in icon comprehension and the stimulus cues that individuals utilize to facilitate identification. In this study, we examined predictors of icon identification as participants gained experience with icons over a series of learning trials. A dynamic pattern of findings emerged in which the primary predictors of identification changed as learning progressed. In early learning trials, semantic distance (the closeness of the relationship between icon and function) was the best predictor of performance, accounting for up to 55% of the variance observed, whereas familiarity with the function was more important in later trials. Other stimulus characteristics, such as our familiarity with the graphic in the icon and its concreteness, were also found to be important for icon design. The theoretical implications of these findings are discussed, with particular emphasis on the parallels with picture naming. The icon identification norms from this study may be downloaded from brm.psychonomic-journals.org/content/supplemental.

Covalent bonds are created by the drive of electron waves to lower their kinetic energy through expansion

PubMed Central

Schmidt, Michael W.; Ivanic, Joseph; Ruedenberg, Klaus

2014-01-01

An analysis based on the variation principle shows that in the molecules H2+, H2, B2, C2, N2, O2, F2, covalent bonding is driven by the attenuation of the kinetic energy that results from the delocalization of the electronic wave function. For molecular geometries around the equilibrium distance, two features of the wave function contribute to this delocalization: (i) Superposition of atomic orbitals extends the electronic wave function from one atom to two or more atoms; (ii) intra-atomic contraction of the atomic orbitals further increases the inter-atomic delocalization. The inter-atomic kinetic energy lowering that (perhaps counter-intuitively) is a consequence of the intra-atomic contractions drives these contractions (which per se would increase the energy). Since the contractions necessarily encompass both, the intra-atomic kinetic and potential energy changes (which add to a positive total), the fact that the intra-atomic potential energy change renders the total potential binding energy negative does not alter the fact that it is the kinetic delocalization energy that drives the bond formation. PMID:24880263

Covalent bonds are created by the drive of electron waves to lower their kinetic energy through expansion.

PubMed

Schmidt, Michael W; Ivanic, Joseph; Ruedenberg, Klaus

2014-05-28

An analysis based on the variation principle shows that in the molecules H2 (+), H2, B2, C2, N2, O2, F2, covalent bonding is driven by the attenuation of the kinetic energy that results from the delocalization of the electronic wave function. For molecular geometries around the equilibrium distance, two features of the wave function contribute to this delocalization: (i) Superposition of atomic orbitals extends the electronic wave function from one atom to two or more atoms; (ii) intra-atomic contraction of the atomic orbitals further increases the inter-atomic delocalization. The inter-atomic kinetic energy lowering that (perhaps counter-intuitively) is a consequence of the intra-atomic contractions drives these contractions (which per se would increase the energy). Since the contractions necessarily encompass both, the intra-atomic kinetic and potential energy changes (which add to a positive total), the fact that the intra-atomic potential energy change renders the total potential binding energy negative does not alter the fact that it is the kinetic delocalization energy that drives the bond formation.

SPARX, a new environment for Cryo-EM image processing.

PubMed

Hohn, Michael; Tang, Grant; Goodyear, Grant; Baldwin, P R; Huang, Zhong; Penczek, Pawel A; Yang, Chao; Glaeser, Robert M; Adams, Paul D; Ludtke, Steven J

2007-01-01

SPARX (single particle analysis for resolution extension) is a new image processing environment with a particular emphasis on transmission electron microscopy (TEM) structure determination. It includes a graphical user interface that provides a complete graphical programming environment with a novel data/process-flow infrastructure, an extensive library of Python scripts that perform specific TEM-related computational tasks, and a core library of fundamental C++ image processing functions. In addition, SPARX relies on the EMAN2 library and cctbx, the open-source computational crystallography library from PHENIX. The design of the system is such that future inclusion of other image processing libraries is a straightforward task. The SPARX infrastructure intelligently handles retention of intermediate values, even those inside programming structures such as loops and function calls. SPARX and all dependencies are free for academic use and available with complete source.

Modeling cation/anion-water interactions in functional aluminosilicate structures.

PubMed

Richards, A J; Barnes, P; Collins, D R; Christodoulos, F; Clark, S M

1995-02-01

A need for the computer simulation of hydration/dehydration processes in functional aluminosilicate structures has been noted. Full and realistic simulations of these systems can be somewhat ambitious and require the aid of interactive computer graphics to identify key structural/chemical units, both in the devising of suitable water-ion simulation potentials and in the analysis of hydrogen-bonding schemes in the subsequent simulation studies. In this article, the former is demonstrated by the assembling of a range of essential water-ion potentials. These span the range of formal charges from +4e to -2e, and are evaluated in the context of three types of structure: a porous zeolite, calcium silicate cement, and layered clay. As an example of the latter, the computer graphics output from Monte Carlo computer simulation studies of hydration/dehydration in calcium-zeolite A is presented.

Real-Space Density Functional Theory on Graphical Processing Units: Computational Approach and Comparison to Gaussian Basis Set Methods.

PubMed

Andrade, Xavier; Aspuru-Guzik, Alán

2013-10-08

We discuss the application of graphical processing units (GPUs) to accelerate real-space density functional theory (DFT) calculations. To make our implementation efficient, we have developed a scheme to expose the data parallelism available in the DFT approach; this is applied to the different procedures required for a real-space DFT calculation. We present results for current-generation GPUs from AMD and Nvidia, which show that our scheme, implemented in the free code Octopus, can reach a sustained performance of up to 90 GFlops for a single GPU, representing a significant speed-up when compared to the CPU version of the code. Moreover, for some systems, our implementation can outperform a GPU Gaussian basis set code, showing that the real-space approach is a competitive alternative for DFT simulations on GPUs.

A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies.

PubMed

Ito, Hiroshi; Yokoi, Takashi; Ikoma, Yoko; Shidahara, Miho; Seki, Chie; Naganawa, Mika; Takahashi, Hidehiko; Takano, Harumasa; Kimura, Yuichi; Ichise, Masanori; Suhara, Tetsuya

2010-01-01

In positron emission tomography (PET) studies with radioligands for neuroreceptors, tracer kinetics have been described by the standard two-tissue compartment model that includes the compartments of nondisplaceable binding and specific binding to receptors. In the present study, we have developed a new graphic plot analysis to determine the total distribution volume (V(T)) and nondisplaceable distribution volume (V(ND)) independently, and therefore the binding potential (BP(ND)). In this plot, Y(t) is the ratio of brain tissue activity to time-integrated arterial input function, and X(t) is the ratio of time-integrated brain tissue activity to time-integrated arterial input function. The x-intercept of linear regression of the plots for early phase represents V(ND), and the x-intercept of linear regression of the plots for delayed phase after the equilibrium time represents V(T). BP(ND) can be calculated by BP(ND)=V(T)/V(ND)-1. Dynamic PET scanning with measurement of arterial input function was performed on six healthy men after intravenous rapid bolus injection of [(11)C]FLB457. The plot yielded a curve in regions with specific binding while it yielded a straight line through all plot data in regions with no specific binding. V(ND), V(T), and BP(ND) values calculated by the present method were in good agreement with those by conventional non-linear least-squares fitting procedure. This method can be used to distinguish graphically whether the radioligand binding includes specific binding or not.

Models of supply function equilibrium with applications to the electricity industry

NASA Astrophysics Data System (ADS)

Aromi, J. Daniel

Electricity market design requires tools that result in a better understanding of incentives of generators and consumers. Chapter 1 and 2 provide tools and applications of these tools to analyze incentive problems in electricity markets. In chapter 1, models of supply function equilibrium (SFE) with asymmetric bidders are studied. I prove the existence and uniqueness of equilibrium in an asymmetric SFE model. In addition, I propose a simple algorithm to calculate numerically the unique equilibrium. As an application, a model of investment decisions is considered that uses the asymmetric SFE as an input. In this model, firms can invest in different technologies, each characterized by distinct variable and fixed costs. In chapter 2, option contracts are introduced to a supply function equilibrium (SFE) model. The uniqueness of the equilibrium in the spot market is established. Comparative statics results on the effect of option contracts on the equilibrium price are presented. A multi-stage game where option contracts are traded before the spot market stage is considered. When contracts are optimally procured by a central authority, the selected profile of option contracts is such that the spot market price equals marginal cost for any load level resulting in a significant reduction in cost. If load serving entities (LSEs) are price takers, in equilibrium, there is no trade of option contracts. Even when LSEs have market power, the central authority's solution cannot be implemented in equilibrium. In chapter 3, we consider a game in which a buyer must repeatedly procure an input from a set of firms. In our model, the buyer is able to sign long term contracts that establish the likelihood with which the next period contract is awarded to an entrant or the incumbent. We find that the buyer finds it optimal to favor the incumbent, this generates more intense competition between suppliers. In a two period model we are able to completely characterize the optimal mechanism.

Contraction dynamics and function of the muscle-tendon complex depend on the muscle fibre-tendon length ratio: a simulation study.

PubMed

Mörl, Falk; Siebert, Tobias; Häufle, Daniel

2016-02-01

Experimental studies show different muscle-tendon complex (MTC) functions (e.g. motor or spring) depending on the muscle fibre-tendon length ratio. Comparing different MTC of different animals examined experimentally, the extracted MTC functions are biased by, for example, MTC-specific pennation angle and fibre-type distribution or divergent experimental protocols (e.g. influence of temperature or stimulation on MTC force). Thus, a thorough understanding of variation of these inner muscle fibre-tendon length ratios on MTC function is difficult. In this study, we used a hill-type muscle model to simulate MTC. The model consists of a contractile element (CE) simulating muscle fibres, a serial element (SE) as a model for tendon, and a parallel elastic element (PEE) modelling tissue in parallel to the muscle fibres. The simulation examines the impact of length variations of these components on contraction dynamics and MTC function. Ensuring a constant overall length of the MTC by L(MTC) = L(SE) + L(CE), the SE rest length was varied over a broad physiological range from 0.1 to 0.9 MTC length. Five different MTC functions were investigated by simulating typical physiological experiments: the stabilising function with isometric contractions, the motor function with contractions against a weight, the capability of acceleration with contractions against a small inertial mass, the braking function by decelerating a mass, and the spring function with stretch-shortening cycles. The ratio of SE and CE mainly determines the MTC function. MTC with comparably short tendon generates high force and maximal shortening velocity and is able to produce maximal work and power. MTC with long tendon is suitable to store and release a maximum amount of energy. Variation of muscle fibre-tendon ratio yielded two peaks for MTC's force response for short and long SE lengths. Further, maximum work storage capacity of the SE is at long relL(SE,0). Impact of fibre-tendon length ratio on MTC functions will be discussed. Considering a constant set of MTC parameters, quantitative changes in MTC performance (work, stiffness, force, energy storage, dissipation) depending on varying muscle fibre-tendon length ratio were provided, which enables classification and grading of different MTC designs.

Treatment with a nitric oxide-donating NSAID alleviates functional muscle ischemia in the mouse model of Duchenne muscular dystrophy.

PubMed

Thomas, Gail D; Ye, Jianfeng; De Nardi, Claudio; Monopoli, Angela; Ongini, Ennio; Victor, Ronald G

2012-01-01

In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystrophin deficiency causes loss of neuronal nitric oxide synthase (nNOSμ) from the sarcolemma, producing functional ischemia when the muscles are exercised. We asked if functional muscle ischemia would be eliminated and normal blood flow regulation restored by treatment with an exogenous nitric oxide (NO)-donating drug. Beginning at 8 weeks of age, mdx mice were fed a standard diet supplemented with 1% soybean oil alone or in combination with a low (15 mg/kg) or high (45 mg/kg) dose of HCT 1026, a NO-donating nonsteroidal anti-inflammatory agent which has previously been shown to slow disease progression in the mdx model. After 1 month of treatment, vasoconstrictor responses to intra-arterial norepinephrine (NE) were compared in resting and contracting hindlimbs. In untreated mdx mice, the usual effect of muscle contraction to attenuate NE-mediated vasoconstriction was impaired, resulting in functional ischemia: NE evoked similar decreases in femoral blood flow velocity and femoral vascular conductance (FVC) in the contracting compared to resting hindlimbs (ΔFVC contraction/ΔFVC rest=0.88 ± 0.03). NE-induced functional ischemia was unaffected by low dose HCT 1026 (ΔFVC ratio=0.92 ± 0.04; P>0.05 vs untreated), but was alleviated by the high dose of the drug (ΔFVC ratio=0.22 ± 0.03; P<0.05 vs untreated or low dose). The beneficial effect of high dose HCT 1026 was maintained with treatment up to 3 months. The effect of the NO-donating drug HCT 1026 to normalize blood flow regulation in contracting mdx mouse hindlimb muscles suggests a putative novel treatment for DMD. Further translational research is warranted.

Interactive design of generic chemical patterns.

PubMed

Schomburg, Karen T; Wetzer, Lars; Rarey, Matthias

2013-07-01

Every medicinal chemist has to create chemical patterns occasionally for querying databases, applying filters or describing functional groups. However, the representations of chemical patterns have been so far limited to languages with highly complex syntax, handicapping the application of patterns. Graphic pattern editors similar to chemical editors can facilitate the work with patterns. In this article, we review the interfaces of frequently used web search engines for chemical patterns. We take a look at pattern editing concepts of standalone chemical editors and finally present a completely new, unpublished graphical approach to pattern design, the SMARTSeditor. Copyright © 2013 Elsevier Ltd. All rights reserved.

Investigation of ODE integrators using interactive graphics. [Ordinary Differential Equations

NASA Technical Reports Server (NTRS)

Brown, R. L.

1978-01-01

Two FORTRAN programs using an interactive graphic terminal to generate accuracy and stability plots for given multistep ordinary differential equation (ODE) integrators are described. The first treats the fixed stepsize linear case with complex variable solutions, and generates plots to show accuracy and error response to step driving function of a numerical solution, as well as the linear stability region. The second generates an analog to the stability region for classes of non-linear ODE's as well as accuracy plots. Both systems can compute method coefficients from a simple specification of the method. Example plots are given.

Research principles and the construction of mnemonic diagrams

NASA Technical Reports Server (NTRS)

Venda, V. F.; Mitkin, A. A.

1973-01-01

Mnemonic diagrams are defined as a variety of information display devices, the essential element of which is conventional graphical presentation of technological or functional-operational links in a controlled system or object. Graphically displaying the operational structure of an object, the interd dependence between different parameters, and the interdependence between indicators and control organs, the mneomonic diagram reduces the load on the operator's memory and facilitates perception and reprocessing of information and decision making, while at the same time playing the role of visual support to the information activity of the operator. The types of mnemonic diagrams are listed.

Inferring metabolic networks using the Bayesian adaptive graphical lasso with informative priors.

PubMed

Peterson, Christine; Vannucci, Marina; Karakas, Cemal; Choi, William; Ma, Lihua; Maletić-Savatić, Mirjana

2013-10-01

Metabolic processes are essential for cellular function and survival. We are interested in inferring a metabolic network in activated microglia, a major neuroimmune cell in the brain responsible for the neuroinflammation associated with neurological diseases, based on a set of quantified metabolites. To achieve this, we apply the Bayesian adaptive graphical lasso with informative priors that incorporate known relationships between covariates. To encourage sparsity, the Bayesian graphical lasso places double exponential priors on the off-diagonal entries of the precision matrix. The Bayesian adaptive graphical lasso allows each double exponential prior to have a unique shrinkage parameter. These shrinkage parameters share a common gamma hyperprior. We extend this model to create an informative prior structure by formulating tailored hyperpriors on the shrinkage parameters. By choosing parameter values for each hyperprior that shift probability mass toward zero for nodes that are close together in a reference network, we encourage edges between covariates with known relationships. This approach can improve the reliability of network inference when the sample size is small relative to the number of parameters to be estimated. When applied to the data on activated microglia, the inferred network includes both known relationships and associations of potential interest for further investigation.

Inferring metabolic networks using the Bayesian adaptive graphical lasso with informative priors

PubMed Central

PETERSON, CHRISTINE; VANNUCCI, MARINA; KARAKAS, CEMAL; CHOI, WILLIAM; MA, LIHUA; MALETIĆ-SAVATIĆ, MIRJANA

2014-01-01

Metabolic processes are essential for cellular function and survival. We are interested in inferring a metabolic network in activated microglia, a major neuroimmune cell in the brain responsible for the neuroinflammation associated with neurological diseases, based on a set of quantified metabolites. To achieve this, we apply the Bayesian adaptive graphical lasso with informative priors that incorporate known relationships between covariates. To encourage sparsity, the Bayesian graphical lasso places double exponential priors on the off-diagonal entries of the precision matrix. The Bayesian adaptive graphical lasso allows each double exponential prior to have a unique shrinkage parameter. These shrinkage parameters share a common gamma hyperprior. We extend this model to create an informative prior structure by formulating tailored hyperpriors on the shrinkage parameters. By choosing parameter values for each hyperprior that shift probability mass toward zero for nodes that are close together in a reference network, we encourage edges between covariates with known relationships. This approach can improve the reliability of network inference when the sample size is small relative to the number of parameters to be estimated. When applied to the data on activated microglia, the inferred network includes both known relationships and associations of potential interest for further investigation. PMID:24533172

SimHap GUI: an intuitive graphical user interface for genetic association analysis.

PubMed

Carter, Kim W; McCaskie, Pamela A; Palmer, Lyle J

2008-12-25

Researchers wishing to conduct genetic association analysis involving single nucleotide polymorphisms (SNPs) or haplotypes are often confronted with the lack of user-friendly graphical analysis tools, requiring sophisticated statistical and informatics expertise to perform relatively straightforward tasks. Tools, such as the SimHap package for the R statistics language, provide the necessary statistical operations to conduct sophisticated genetic analysis, but lacks a graphical user interface that allows anyone but a professional statistician to effectively utilise the tool. We have developed SimHap GUI, a cross-platform integrated graphical analysis tool for conducting epidemiological, single SNP and haplotype-based association analysis. SimHap GUI features a novel workflow interface that guides the user through each logical step of the analysis process, making it accessible to both novice and advanced users. This tool provides a seamless interface to the SimHap R package, while providing enhanced functionality such as sophisticated data checking, automated data conversion, and real-time estimations of haplotype simulation progress. SimHap GUI provides a novel, easy-to-use, cross-platform solution for conducting a range of genetic and non-genetic association analyses. This provides a free alternative to commercial statistics packages that is specifically designed for genetic association analysis.

Intellectual system of identification of Arabic graphics

NASA Astrophysics Data System (ADS)

Abdoullayeva, Gulchin G.; Aliyev, Telman A.; Gurbanova, Nazakat G.

2001-08-01

The studies made by using the domain of graphic images allowed creating facilities of the artificial intelligence for letters, letter combinations etc. for various graphics and prints. The work proposes a system of recognition and identification of symbols of the Arabic graphics, which has its own specificity as compared to Latin and Cyrillic ones. The starting stage of the recognition and the identification is coding with further entry of information into a computer. Here the problem of entry is one of the essentials. For entry of a large volume of information in the unit of time a scanner is usually employed. Along with the scanner the authors suggest their elaboration of technical facilities for effective input and coding of the information. For refinement of symbols not identified from the scanner mostly for a small bulk of information the developed coding devices are used directly in the process of writing. The functional design of the software is elaborated on the basis of the heuristic model of the creative activity of a researcher and experts in the description and estimation of states of the weakly formalizable systems on the strength of the methods of identification and of selection of geometric features.

Engineering applications and analysis of vibratory motion fourth order fluid film over the time dependent heated flat plate

NASA Astrophysics Data System (ADS)

Mohmand, Muhammad Ismail; Mamat, Mustafa Bin; Shah, Qayyum

2017-07-01

This article deals with the time dependent analysis of thermally conducting and Magneto-hydrodynamic (MHD) liquid film flow of a fourth order fluid past a vertical and vibratory plate. In this article have been developed for higher order complex nature fluids. The governing-equations have been modeled in the terms of nonlinear partial differential equations with the help of physical boundary circumstances. Two different analytical approaches i.e. Adomian decomposition method (ADM) and the optimal homotopy asymptotic method (OHAM), have been used for discoveryof the series clarification of the problems. Solutions obtained via two diversemethods have been compared using the graphs, tables and found an excellent contract. Variants of the embedded flow parameters in the solution have been analysed through the graphical diagrams.

USL NASA/RECON project presentations at the 1985 ACM Computer Science Conference: Abstracts and visuals

NASA Technical Reports Server (NTRS)

Dominick, Wayne D. (Editor); Chum, Frank Y.; Gallagher, Suzy; Granier, Martin; Hall, Philip P.; Moreau, Dennis R.; Triantafyllopoulos, Spiros

1985-01-01

This Working Paper Series entry represents the abstracts and visuals associated with presentations delivered by six USL NASA/RECON research team members at the above named conference. The presentations highlight various aspects of NASA contract activities pursued by the participants as they relate to individual research projects. The titles of the six presentations are as follows: (1) The Specification and Design of a Distributed Workstation; (2) An Innovative, Multidisciplinary Educational Program in Interactive Information Storage and Retrieval; (3) Critical Comparative Analysis of the Major Commercial IS and R Systems; (4) Design Criteria for a PC-Based Common User Interface to Remote Information Systems; (5) The Design of an Object-Oriented Graphics Interface; and (6) Knowledge-Based Information Retrieval: Techniques and Applications.

A study of the passive gait of a compass-like biped robot: Symmetry and chaos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goswami, A.; Espiau, B.; Thuilot, B.

1998-12-01

The focus of this work is a systematic study of the passive gait of a compass-like planar, biped robot on inclined slopes. The robot is kinematically equivalent to a double pendulum, possessing two kneeless legs with point masses and a third point mass at the hip joint. Three parameters, namely, the ground-slope angle and the normalized mass and length of the robot describe its gait. The authors show that in response to a continuous change in any one of its parameters, the symmetric and steady stable gait of the unpowered robot gradually evolves through a regime of bifurcations characterized bymore » progressively complicated asymmetric gaits, eventually arriving at an apparently chaotic gait where not two steps are identical. The robot can maintain this gait indefinitely. A necessary (but not sufficient) condition for the stability of such gaits is the contraction of the phase-fluid volume. For this frictionless robot, the volume contraction, which the authors compute, is caused by the dissipative effects of the ground-impact model. In the chaotic regime, the fractal dimension of the robot`s strange attractor (2.07) compared to its state-space dimension (4) also reveals strong contraction. The authors present a novel graphical technique based on the first return map that compactly captures the entire evolution of the gait, from symmetry to chaos. Additional passive dissipative elements in the robot joint results in a significant improvement in the stability and the versatility of the gait, and provide a rich repertoire for simple controls laws.« less

Stretch or contraction induced inversion of rectification in diblock molecular junctions

NASA Astrophysics Data System (ADS)

Zhang, Guang-Ping; Hu, Gui-Chao; Song, Yang; Xie, Zhen; Wang, Chuan-Kui

2013-09-01

Based on ab initio theory and nonequilibrium Green's function method, the effect of stretch or contraction on the rectification in diblock co-oligomer molecular diodes is investigated theoretically. Interestingly, an inversion of rectifying direction induced by stretching or contracting the molecular junctions, which is closely related to the number of the pyrimidinyl-phenyl units, is proposed. The analysis of the molecular projected self-consistent Hamiltonian and the evolution of the frontier molecular orbitals as well as transmission coefficients under external biases gives an inside view of the observed results. It reveals that the asymmetric molecular level shift and asymmetric evolution of orbital wave functions under biases are competitive mechanisms for rectification. The stretching or contracting induced inversion of the rectification is due to the conversion of the dominant mechanism. This work suggests a feasible technique to manipulate the rectification performance in molecular diodes by use of the mechanically controllable method.

A STRICTLY CONTRACTIVE PEACEMAN-RACHFORD SPLITTING METHOD FOR CONVEX PROGRAMMING.

PubMed

Bingsheng, He; Liu, Han; Wang, Zhaoran; Yuan, Xiaoming

2014-07-01

In this paper, we focus on the application of the Peaceman-Rachford splitting method (PRSM) to a convex minimization model with linear constraints and a separable objective function. Compared to the Douglas-Rachford splitting method (DRSM), another splitting method from which the alternating direction method of multipliers originates, PRSM requires more restrictive assumptions to ensure its convergence, while it is always faster whenever it is convergent. We first illustrate that the reason for this difference is that the iterative sequence generated by DRSM is strictly contractive, while that generated by PRSM is only contractive with respect to the solution set of the model. With only the convexity assumption on the objective function of the model under consideration, the convergence of PRSM is not guaranteed. But for this case, we show that the first t iterations of PRSM still enable us to find an approximate solution with an accuracy of O (1/ t ). A worst-case O (1/ t ) convergence rate of PRSM in the ergodic sense is thus established under mild assumptions. After that, we suggest attaching an underdetermined relaxation factor with PRSM to guarantee the strict contraction of its iterative sequence and thus propose a strictly contractive PRSM. A worst-case O (1/ t ) convergence rate of this strictly contractive PRSM in a nonergodic sense is established. We show the numerical efficiency of the strictly contractive PRSM by some applications in statistical learning and image processing.

Risk transfer and accountability in managed care organizations' carve-out contracts.

PubMed

Garnick, D W; Horgan, C M; Hodgkin, D; Merrick, E L; Goldin, D; Ritter, G; Skwara, K C

2001-11-01

This study examined characteristics of contracts between managed care organizations (MCOs) and managed behavioral health organizations (MBHOs) in terms of delegation of functions, financial arrangements between the MCO and the MBHO, and the use of performance standards. Nationally representative administrative and clinical information about the three largest types of commercial products offered by 434 MCOs in 60 market areas was gathered by telephone survey. These products comprised services provided by health maintenance organizations, preferred provider organizations, and point-of-service plans. Chi square tests were performed between pairings of all three types of products to ascertain differences in the degree to which claims processing, maintenance of provider networks, utilization management, case management, and quality improvement were delegated to MBHOs through specialty contracts among the various types of products. Contractual specifications about capitation arrangements, risk sharing, the use of performance standards, and final utilization review decisions were also compared. For all types of products, almost all the major functions were contracted by the MCO to the MBHO. Although most contracts assigned some risk for the costs of services to the MBHO, the degree of this risk varied by product type. Except in the case of preferred-provider organizations, a large number of performance standards were identified in MCOs' contracts with MBHOs, although financial incentives were rarely tied to such standards. MCOs that contract with MBHOs place major responsibility, both financial and administrative, on the vendors.

Computer assisted generation of the matrix elements between contracted wavefunctions in a Complete Active Space scheme

NASA Astrophysics Data System (ADS)

Angeli, C.; Cimiraglia, R.

2005-02-01

Starting from a CAS-SCF calculation a sequence of contracted functions can be generated by applying strings of spin-traced replacement operators to the CAS-SCF solution. The laborious task of producing the Hamiltonian matrix elements between such functions can be substantially reduced making use of a computer algebra system. An implementation employing the MuPAD system is presented and illustrated.

Emotional reaction facilitates the brain and behavioural impact of graphic cigarette warning labels in smokers.

PubMed

Wang, An-Li; Lowen, Steven B; Romer, Daniel; Giorno, Mario; Langleben, Daniel D

2015-05-01

Warning labels on cigarette packages are an important venue for information about the hazards of smoking. The 2009 US Family Smoking Prevention and Tobacco Control Act mandated replacing the current text-only labels with graphic warning labels. However, labels proposed by the Food and Drug Administration (FDA) were challenged in court by the tobacco companies, who argued successfully that the proposed labels needlessly encroached on their right to free speech, in part because they included images of high emotional salience that indiscriminately frightened rather than informed consumers. We used functional MRI to examine the effects of graphic warning labels' emotional salience on smokers' brain activity and cognition. Twenty-four smokers viewed a random sequence of blocks of graphic warning labels that have been rated high or low on an 'emotional reaction' scale in previous research. We found that labels rated high on emotional reaction were better remembered, associated with reduction in the urge to smoke, and produced greater brain response in the amygdala, hippocampi, inferior frontal gyri and the insulae. Recognition memory and craving are, respectively, correlates of effectiveness of addiction-related public health communications and interventions, and amygdala activation facilitates the encoding of emotional memories. Thus, our results suggest that emotional reaction to graphic warning labels contributes to their public health impact and may be an integral part of the neural mechanisms underlying their effectiveness. Given the urgency of the debate about the constitutional risks and public health benefits of graphic warning labels, these preliminary findings warrant consideration while longitudinal clinical studies are underway. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Regression Models for Identifying Noise Sources in Magnetic Resonance Images

PubMed Central

Zhu, Hongtu; Li, Yimei; Ibrahim, Joseph G.; Shi, Xiaoyan; An, Hongyu; Chen, Yashen; Gao, Wei; Lin, Weili; Rowe, Daniel B.; Peterson, Bradley S.

2009-01-01

Stochastic noise, susceptibility artifacts, magnetic field and radiofrequency inhomogeneities, and other noise components in magnetic resonance images (MRIs) can introduce serious bias into any measurements made with those images. We formally introduce three regression models including a Rician regression model and two associated normal models to characterize stochastic noise in various magnetic resonance imaging modalities, including diffusion-weighted imaging (DWI) and functional MRI (fMRI). Estimation algorithms are introduced to maximize the likelihood function of the three regression models. We also develop a diagnostic procedure for systematically exploring MR images to identify noise components other than simple stochastic noise, and to detect discrepancies between the fitted regression models and MRI data. The diagnostic procedure includes goodness-of-fit statistics, measures of influence, and tools for graphical display. The goodness-of-fit statistics can assess the key assumptions of the three regression models, whereas measures of influence can isolate outliers caused by certain noise components, including motion artifacts. The tools for graphical display permit graphical visualization of the values for the goodness-of-fit statistic and influence measures. Finally, we conduct simulation studies to evaluate performance of these methods, and we analyze a real dataset to illustrate how our diagnostic procedure localizes subtle image artifacts by detecting intravoxel variability that is not captured by the regression models. PMID:19890478

Analysis of Contraction Joint Width Influence on Load Stress of Pavement Panels

NASA Astrophysics Data System (ADS)

Gao, Wei; Cui, Wei; Sun, Wei

2018-05-01

The width of transverse contraction joint of the cement road varies with temperatures, which leads to changes in load transmission among plates of the road surface and affects load stress of the road plates. Three-dimensional element analysis software EverFE is used to address the relation between the contraction joint width and road surface load stress, revealing the impact of reducing contraction joint width. The results could be of critical value in maintaining road functions and extending the service life of cement road surfaces.

Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice

PubMed Central

Pizza, Francis X; Peterson, Jennifer M; Baas, Joel H; Koh, Timothy J

2005-01-01

We tested the hypotheses that: (1) neutrophil accumulation after contraction-induced muscle injury is dependent on the β2 integrin CD18, (2) neutrophils contribute to muscle injury and oxidative damage after contraction-induced muscle injury, and (3) neutrophils aid the resolution of contraction-induced muscle injury. These hypotheses were tested by exposing extensor digitorum longus (EDL) muscles of mice deficient in CD18 (CD18−/−; Itgb2tm1Bay) and of wild type mice (C57BL/6) to in situ lengthening contractions and by quantifying markers of muscle inflammation, injury, oxidative damage and regeneration/repair. Neutrophil concentrations were significantly elevated in wild type mice at 6 h and 3 days post-lengthening contractions; however, neutrophils remained at control levels at these time points in CD18−/− mice. These data indicate that CD18 is required for neutrophil accumulation after contraction-induced muscle injury. Histological and functional (isometric force deficit) signs of muscle injury and total carbonyl content, a marker of oxidative damage, were significantly higher in wild type relative to CD18−/− mice 3 days after lengthening contractions. These data show that neutrophils exacerbate contraction-induced muscle injury. After statistically controlling for differences in the force deficit at 3 days, wild type mice also demonstrated a higher force deficit at 7 days, a lower percentage of myofibres expressing embryonic myosin heavy chain at 3 and 7 days, and a smaller cross sectional area of central nucleated myofibres at 14 days relative to CD18−/− mice. These observations suggest that neutrophils impair the restoration of muscle structure and function after injury. In conclusion, neutrophil accumulation after contraction-induced muscle injury is dependent on CD18. Furthermore, neutrophils appear to contribute to muscle injury and impair some of the events associated with the resolution of contraction-induced muscle injury. PMID:15550464

Characteristics of power spectrum density function of EMG during muscle contraction below 30%MVC.

PubMed

Roman-Liu, Danuta; Konarska, Maria

2009-10-01

The aim of the study was to quantify changes in PSDF frequency bands of the EMG signal and EMG parameters such as MF, MPF and zero crossing, with an increase in the level of muscle contractions in the range from 0.5% to 30% RMS(max) and to determine the frequency bands with the lowest dependency on RMS level so that this could be used in investigating muscle fatigue. Sixteen men, aged from 23 to 33 years old (mean 26.1), who participated in the study performed two force exertion tests. Fragments of EMG which corresponded to the levels of muscle contraction of 0.5%, 1%, 2.5%, 5%, 10%, 15%, 20%, 25%, 30% RMS(max) registered from left and right trapezius pars descendents (TP) and left and right extensor digitorum superficialis (ED) muscles were selected for analysis. The analysis included changes in standard parameters of the EMG signal and changes in PSDF frequency bands, which occurred across muscle contraction levels. To analyze changes in PSDF across the level of muscle contraction, the spectrum was divided into six frequency bandwidths. The analysis of parameters focused on the differences in those parameters between the analyzed muscles, at different levels of muscle contraction. The study revealed that, at muscle contraction levels below 5% RMSmax, contraction level influences standard parameters of the EMG signal and that at such levels of muscle contraction every change in muscle contraction level (recruitment of additional MUs) is reflected in PSDF. The frequency band with the lowest dependency on contraction level was 76-140 Hz for which in both muscles no contraction level effect was detected for contraction levels above 5% RMS(max). The reproducibility of the results was very high, since the observations in of the left and right muscles were almost equal. The other factor, which strongly influences PSDF of the EMG signal, is probably the examined muscle structure (muscle morphology, size, function, subcutaneous layer, cross talk). It seems that low frequency bands up to 25 Hz are especially feasible for type of muscle.

Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy

NASA Astrophysics Data System (ADS)

Belau, Markus; Ninck, Markus; Hering, Gernot; Spinelli, Lorenzo; Contini, Davide; Torricelli, Alessandro; Gisler, Thomas

2010-09-01

We introduce a method for noninvasively measuring muscle contraction in vivo, based on near-infrared diffusing-wave spectroscopy (DWS). The method exploits the information about time-dependent shear motions within the contracting muscle that are contained in the temporal autocorrelation function g(1)(τ,t) of the multiply scattered light field measured as a function of lag time, τ, and time after stimulus, t. The analysis of g(1)(τ,t) measured on the human M. biceps brachii during repetitive electrical stimulation, using optical properties measured with time-resolved reflectance spectroscopy, shows that the tissue dynamics giving rise to the speckle fluctuations can be described by a combination of diffusion and shearing. The evolution of the tissue Cauchy strain e(t) shows a strong correlation with the force, indicating that a significant part of the shear observed with DWS is due to muscle contraction. The evolution of the DWS decay time shows quantitative differences between the M. biceps brachii and the M. gastrocnemius, suggesting that DWS allows to discriminate contraction of fast- and slow-twitch muscle fibers.

An Annotated Bibliography of Practical Tests for Young Children. (Revised 1976).

ERIC Educational Resources Information Center

Anttonen, Judith; Garman, Charlotte G.

There are three parts to this bibliography of tests for children aged two to six. First is an alphabetical index of the 89 tests with a graphic display to indicate which tests measure which of the following functions: (1) intellectual functions or attained skills; (2) oral language communication; (3) self-concept, personality, sociability,…

Teaching a Concept with GeoGebra: Periodicity of Trigonometric Functions

ERIC Educational Resources Information Center

Kepceoglu, Ibrahim; Yavuz, llyas

2016-01-01

Being one of the major subjects in high school mathematics curriculum, trigonometry links algebraic, geometric and graphical reasoning. The aim of this study is to investigate the effect of GeoGebra in the teaching of the concept of the periodicity of trigonometric functions. In this study, it is investigated how effective is the dynamic…

Introducing Algebra through the Graphical Representation of Functions: A Study among LD Students

ERIC Educational Resources Information Center

Sauriol, Jennifer

2013-01-01

This longitudinal study evaluates the impact of a new Algebra 1 course at a High School for language-based learning-disabled (LD) students. The new course prioritized the teaching of relationship graphs and functions as an introduction to algebra. Across three studies, the dissertation documents and evaluates the progress made by LD high school…

Daubechies wavelets for linear scaling density functional theory.

PubMed

Mohr, Stephan; Ratcliff, Laura E; Boulanger, Paul; Genovese, Luigi; Caliste, Damien; Deutsch, Thierry; Goedecker, Stefan

2014-05-28

We demonstrate that Daubechies wavelets can be used to construct a minimal set of optimized localized adaptively contracted basis functions in which the Kohn-Sham orbitals can be represented with an arbitrarily high, controllable precision. Ground state energies and the forces acting on the ions can be calculated in this basis with the same accuracy as if they were calculated directly in a Daubechies wavelets basis, provided that the amplitude of these adaptively contracted basis functions is sufficiently small on the surface of the localization region, which is guaranteed by the optimization procedure described in this work. This approach reduces the computational costs of density functional theory calculations, and can be combined with sparse matrix algebra to obtain linear scaling with respect to the number of electrons in the system. Calculations on systems of 10,000 atoms or more thus become feasible in a systematic basis set with moderate computational resources. Further computational savings can be achieved by exploiting the similarity of the adaptively contracted basis functions for closely related environments, e.g., in geometry optimizations or combined calculations of neutral and charged systems.

Launching the Next Generation IODP Site Survey Data Bank

NASA Astrophysics Data System (ADS)

Miller, S. P.; Helly, J.; Clark, D.; Eakins, B.; Sutton, D.; Weatherford, J.; Thatch, G.; Miville, B.; Zelt, B.

2005-12-01

The next generation all-digital Site Survey Data Bank (SSDB) became operational on August 15, 2005 as an online resource for Integrated Ocean Drilling Program (IODP) proponents, reviewers, panels and operations, worldwide. There are currently 123 active proposals for drilling at sites distributed across the globe, involving nearly 1000 proponents from more than 40 countries. The goal is to provide an authoritative, persistent, secure, password-controlled and easily-used home for contributed data objects, as proposals evolve through their life cycle from preliminary phases to planned drilling expeditions. Proposal status can be monitored graphically by proposal number, data type or date. A Java SSDBviewer allows discovery of all proposal data objects, displayed over a basemap of global topography, crustal age or other custom maps. Data can be viewed or downloaded under password control. Webform interfaces assist with the uploading of data and metadata. Thirty four different standard data types are currently supported. The system was designed as a fully functioning digital library, not just a database or a web archive, drawing upon the resources of the SIOExplorer Digital Library project. Blocks of metadata are organized to support discovery and use, as appropriate for each data type. The SSDB has been developed by a UCSD team of researchers and computer scientists at the Scripps Institution of Oceanography and the San Diego Supercomputer Center, under contract with IODP Management International Inc., supported by NSF OCE 0432224.

An Investigation of Electrochemomechanical Actuation of Conductive Polyacrylonitrile (PAN) Nanofiber Composites

NASA Astrophysics Data System (ADS)

Gonzalez, Mark A.

A polymer-based nanofiber composite actuator designed for linear actuation was fabricated by electrospinning, actuated by electrolysis, and characterized by electrical and mechanical testing to address performance limitations and understand the activation processing effects on actuation performance. Currently, Electroactive polymers (EAPs) have provided uses in sensory and actuation technology, but have either low force output or expand rather than contract, falling short in capturing the natural motion and function of muscle desperately needed to provide breakthroughs in the bio-medical and robotic fields. Previous research has shown activated Polyacrylonitrile (PAN) fibers having biomimetic functionalities similar to the sarcomere contraction responsible for muscle function. Activated PAN is also known to contract and expand by electrolysis when in close vicinity to the anode and cathode, respectively. PAN nanofibers especially show faster response to changes in environmental pH and improved mechanical properties over larger diameter fibers. Conductive additives were introduced to the electrospinning solution and activated in an attempt to create composite PAN nanofiber gel actuators with improved conductivity and eliminate the need of stiff electrodes. Tensile testing was conducted to examine changes in mechanical properties between annealing and hydrolysis processing. Introducing conductive additives did not show a significant increase in conductivity and created unusable samples, requiring alternative electrode materials. Electrochemical contraction rates up to 25%/ min were achieved. Strains of 58.8%, ultimate stresses up to 77.1 MPa, and moduli of 0.21 MPa were achieved with pure PAN nanofiber mats, surpassing mechanical properties of natural muscles. Improvements to contraction rates and young's moduli are necessary to capture the function and performance of skeletal muscles properly.

Assessment of brain activity during voluntary anal sphincter contraction: Comparative study in women with and without fecal incontinence.

PubMed

Parés, D; Martínez-Vilalta, M; Ortiz, H; Soriano-Mas, C; Maestre-Gonzalez, Y; Pujol, J; Grande, L

2018-04-14

Voluntary anal sphincter function is driven by an extended network of brain structures, most of which are still unknown. Disturbances in this function may cause fecal incontinence. The aim of this study was to characterize the cerebral areas involved in voluntary contraction of the anorectal sphincter in healthy women and in a group of patients with fecal incontinence by using a standardized functional magnetic resonance imaging (fMRI) protocol. This comparative study included 12 healthy women (mean age 53.17 ± 4.93 years) and 12 women with fecal incontinence (56.25 ± 6.94 years). An MRI-compatible anal manometer was used to register voluntary external anal sphincter contraction. During brain fMRI imaging, participants were cued to perform 10-s series of self-paced anal sphincter contractions at an approximate rate of 1 Hz. Brain structures linked to anal sphincter contractions were mapped and the findings were compared between the 2 study groups. There were no differences in the evoked brain activity between the 2 groups. In healthy women, group fMRI analysis revealed significant activations in medial primary motor cortices, supplementary motor area, bilateral putamen, and cerebellum, as well as in the supramarginal gyrus and visual areas. In patients with fecal incontinence, the activation pattern involved similar regions without significant differences with healthy women. This brain fMRI-anorectal protocol was able to map the brain regions linked to voluntary anal sphincter function in healthy and women with fecal incontinence. © 2018 John Wiley & Sons Ltd.

Service quality in contracted facilities.

PubMed

Rabbani, Fauziah; Pradhan, Nousheen Akber; Zaidi, Shehla; Azam, Syed Iqbal; Yousuf, Farheen

2015-01-01

The purpose of this paper is to explore the readiness of contracted and non-contracted first-level healthcare facilities in Pakistan to deliver quality maternal and neonatal health (MNH) care. A balanced scorecard (BSC) was used as the assessment framework. Using a cross-sectional study design, two rural health centers (RHCs) contracted out to Aga Khan Health Service, Pakistan were compared with four government managed RHCs. A BSC was designed to assess RHC readiness to deliver good quality MNH care. In total 20 indicators were developed, representing five BSC domains: health facility functionality, service provision, staff capacity, staff and patient satisfaction. Validated data collection tools were used to collect information. Pearson χ2, Fisher's Exact and the Mann-Whitney tests were applied as appropriate to detect significant service quality differences among the two facilities. Contracted facilities were generally found to be better than non-contracted facilities in all five BSC domains. Patients' inclination for facility-based delivery at contracted facilities was, however, significantly higher than non-contracted facilities (80 percent contracted vs 43 percent non-contracted, p=0.006). The study shows that contracting out initiatives have the potential to improve MNH care. This is the first study to compare MNH service delivery quality across contracted and non-contracted facilities using BSC as the assessment framework.

78 FR 54687 - International Mail Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... Service filing seeking to include a new International Business Reply Service (IBRS) agreement within the... Postal Service seeks to include a new International Business Reply Service (IBRS) agreement (Agreement... a Functionally Equivalent International Business Reply Service Competitive Contract 3 Negotiated...

48 CFR 970.4401-2 - Review and approval.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Management and Operating Contractor Purchasing... contract; (2) The size, experience, ability, reliability, and organization of the management and operating contractor's purchasing function; (3) The internal controls, procedures, and organizational stature of the...

Inhibition linearizes firing rate responses in human motor units: implications for the role of persistent inward currents.

PubMed

Revill, Ann L; Fuglevand, Andrew J

2017-01-01

Motor neurons are the output neurons of the central nervous system and are responsible for controlling muscle contraction. When initially activated during voluntary contraction, firing rates of motor neurons increase steeply but then level out at modest rates. Activation of an intrinsic source of excitatory current at recruitment onset may underlie the initial steep increase in firing rate in motor neurons. We attempted to disable this intrinsic excitatory current by artificially activating an inhibitory reflex. When motor neuron activity was recorded while the inhibitory reflex was engaged, firing rates no longer increased steeply, suggesting that the intrinsic excitatory current was probably responsible for the initial sharp rise in motor neuron firing rate. During graded isometric contractions, motor unit (MU) firing rates increase steeply upon recruitment but then level off at modest rates even though muscle force continues to increase. The mechanisms underlying such firing behaviour are not known although activation of persistent inward currents (PICs) might be involved. PICs are intrinsic, voltage-dependent currents that activate strongly when motor neurons (MNs) are first recruited. Such activation might cause a sharp escalation in depolarizing current and underlie the steep initial rise in MU firing rate. Because PICs can be disabled with synaptic inhibition, we hypothesized that artificial activation of an inhibitory pathway might curb this initial steep rise in firing rate. To test this, human subjects performed slow triangular ramp contractions of the ankle dorsiflexors in the absence and presence of tonic synaptic inhibition delivered to tibialis anterior (TA) MNs by sural nerve stimulation. Firing rate profiles (expressed as a function of contraction force) of TA MUs recorded during these tasks were compared for control and stimulation conditions. Under control conditions, during the ascending phase of the triangular contractions, 93% of the firing rate profiles were best fitted by rising exponential functions. With stimulation, however, firing rate profiles were best fitted with linear functions or with less steeply rising exponentials. Firing rate profiles for the descending phases of the contractions were best fitted with linear functions for both control and stimulation conditions. These results seem consistent with the idea that PICs contribute to non-linear firing rate profiles during ascending but not descending phases of contractions. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

Is there an association between subclinical hypothyroidism and preterm uterine contractions? A prospective observational study.

PubMed

Nassie, Daniel I; Ashwal, Eran; Raban, Oded; Ben-Haroush, Avi; Wiznitzer, Arnon; Yogev, Yariv; Aviram, Amir

2017-04-01

To investigate the association between subclinical hypothyroidism and preterm contractions. Prospective observational study among women at 23 + 0/7 and 34 + 6/7 weeks of gestation, with no known thyroid function abnormality, and preterm uterine contractions (PTC). All patients underwent laboratory evaluation of Thyroid Stimulating Hormone (TSH) and Free Thyroxin (FT4). Patients with and without PTC were compared. No association was found between PTC and subclinical hypothyroidism. Rate of spontaneous preterm delivery (PTD) was comparable between women with abnormal and normal thyroid function tests. Excluding indicated PTD, patients in the study group had a higher rate of spontaneous PTD (24.7% versus 9.6%, p = 0.03). Patients with past PTD and preterm contractions had higher rates of hypothyroxinemia compared with patients without past PTD (54.6% versus 19.0% and 31.2%, p = 0.001), and patients with past PTD (regardless of the presence or absence of PTC) had higher rate of subclinical hypothyroidism compared with patients with PTC and without PTD (59.1% and 66.7% versus 31.6%, p = 0.017). No association was found between PTC and subclinical hypothyroidism in the entire cohort, except for patients with preterm contractions and a history of past PTD. This specific group of patients might benefit from thyroid function evaluation.

Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in the Drosophila Embryo.

PubMed

Baker, Ryan; Nakamura, Naosuke; Chandel, Ishita; Howell, Brooke; Lyalin, Dmitry; Panin, Vladislav M

2018-02-14

Genetic defects in protein O-mannosyltransferase 1 (POMT1) and POMT2 underlie severe muscular dystrophies. POMT genes are evolutionarily conserved in metazoan organisms. In Drosophila , both male and female POMT mutants show a clockwise rotation of adult abdominal segments, suggesting a chirality of underlying pathogenic mechanisms. Here we described and analyzed a similar phenotype in POMT mutant embryos that shows left-handed body torsion. Our experiments demonstrated that coordinated muscle contraction waves are associated with asymmetric embryo rolling, unveiling a new chirality marker in Drosophila development. Using genetic and live-imaging approaches, we revealed that the torsion phenotype results from differential rolling and aberrant patterning of peristaltic waves of muscle contractions. Our results demonstrated that peripheral sensory neurons are required for normal contractions that prevent the accumulation of torsion. We found that POMT mutants show abnormal axonal connections of sensory neurons. POMT transgenic expression limited to sensory neurons significantly rescued the torsion phenotype, axonal connectivity defects, and abnormal contractions in POMT mutant embryos. Together, our data suggested that protein O-mannosylation is required for normal sensory feedback to control coordinated muscle contractions and body posture. This mechanism may shed light on analogous functions of POMT genes in mammals and help to elucidate the etiology of neurological defects in muscular dystrophies. SIGNIFICANCE STATEMENT Protein O-mannosyltransferases (POMTs) are evolutionarily conserved in metazoans. Mutations in POMTs cause severe muscular dystrophies associated with pronounced neurological defects. However, neurological functions of POMTs remain poorly understood. We demonstrated that POMT mutations in Drosophila result in abnormal muscle contractions and cause embryo torsion. Our experiments uncovered a chirality of embryo movements and a unique POMT -dependent mechanism that maintains symmetry of a developing system affected by chiral forces. Furthermore, POMTs were found to be required for proper axon connectivity of sensory neurons, suggesting that O-mannosylation regulates the sensory feedback controlling muscle contractions. This novel POMT function in the peripheral nervous system may shed light on analogous functions in mammals and help to elucidate pathomechanisms of neurological abnormalities in muscular dystrophies. Copyright © 2018 the authors 0270-6474/18/381850-16$15.00/0.

Design strategies and functionality of the Visual Interface for Virtual Interaction Development (VIVID) tool

NASA Technical Reports Server (NTRS)

Nguyen, Lac; Kenney, Patrick J.

1993-01-01

Development of interactive virtual environments (VE) has typically consisted of three primary activities: model (object) development, model relationship tree development, and environment behavior definition and coding. The model and relationship tree development activities are accomplished with a variety of well-established graphic library (GL) based programs - most utilizing graphical user interfaces (GUI) with point-and-click interactions. Because of this GUI format, little programming expertise on the part of the developer is necessary to create the 3D graphical models or to establish interrelationships between the models. However, the third VE development activity, environment behavior definition and coding, has generally required the greatest amount of time and programmer expertise. Behaviors, characteristics, and interactions between objects and the user within a VE must be defined via command line C coding prior to rendering the environment scenes. In an effort to simplify this environment behavior definition phase for non-programmers, and to provide easy access to model and tree tools, a graphical interface and development tool has been created. The principal thrust of this research is to effect rapid development and prototyping of virtual environments. This presentation will discuss the 'Visual Interface for Virtual Interaction Development' (VIVID) tool; an X-Windows based system employing drop-down menus for user selection of program access, models, and trees, behavior editing, and code generation. Examples of these selection will be highlighted in this presentation, as will the currently available program interfaces. The functionality of this tool allows non-programming users access to all facets of VE development while providing experienced programmers with a collection of pre-coded behaviors. In conjunction with its existing, interfaces and predefined suite of behaviors, future development plans for VIVID will be described. These include incorporation of dual user virtual environment enhancements, tool expansion, and additional behaviors.

ARC SDK: A toolbox for distributed computing and data applications

NASA Astrophysics Data System (ADS)

Skou Andersen, M.; Cameron, D.; Lindemann, J.

2014-06-01

Grid middleware suites provide tools to perform the basic tasks of job submission and retrieval and data access, however these tools tend to be low-level, operating on individual jobs or files and lacking in higher-level concepts. User communities therefore generally develop their own application-layer software catering to their specific communities' needs on top of the Grid middleware. It is thus important for the Grid middleware to provide a friendly, well documented and simple to use interface for the applications to build upon. The Advanced Resource Connector (ARC), developed by NorduGrid, provides a Software Development Kit (SDK) which enables applications to use the middleware for job and data management. This paper presents the architecture and functionality of the ARC SDK along with an example graphical application developed with the SDK. The SDK consists of a set of libraries accessible through Application Programming Interfaces (API) in several languages. It contains extensive documentation and example code and is available on multiple platforms. The libraries provide generic interfaces and rely on plugins to support a given technology or protocol and this modular design makes it easy to add a new plugin if the application requires supporting additional technologies.The ARC Graphical Clients package is a graphical user interface built on top of the ARC SDK and the Qt toolkit and it is presented here as a fully functional example of an application. It provides a graphical interface to enable job submission and management at the click of a button, and allows data on any Grid storage system to be manipulated using a visual file system hierarchy, as if it were a regular file system.

Robotics On-Board Trainer (ROBoT)

NASA Technical Reports Server (NTRS)

Johnson, Genevieve; Alexander, Greg

2013-01-01

ROBoT is an on-orbit version of the ground-based Dynamics Skills Trainer (DST) that astronauts use for training on a frequent basis. This software consists of two primary software groups. The first series of components is responsible for displaying the graphical scenes. The remaining components are responsible for simulating the Mobile Servicing System (MSS), the Japanese Experiment Module Remote Manipulator System (JEMRMS), and the H-II Transfer Vehicle (HTV) Free Flyer Robotics Operations. The MSS simulation software includes: Robotic Workstation (RWS) simulation, a simulation of the Space Station Remote Manipulator System (SSRMS), a simulation of the ISS Command and Control System (CCS), and a portion of the Portable Computer System (PCS) software necessary for MSS operations. These components all run under the CentOS4.5 Linux operating system. The JEMRMS simulation software includes real-time, HIL, dynamics, manipulator multi-body dynamics, and a moving object contact model with Tricks discrete time scheduling. The JEMRMS DST will be used as a functional proficiency and skills trainer for flight crews. The HTV Free Flyer Robotics Operations simulation software adds a functional simulation of HTV vehicle controllers, sensors, and data to the MSS simulation software. These components are intended to support HTV ISS visiting vehicle analysis and training. The scene generation software will use DOUG (Dynamic On-orbit Ubiquitous Graphics) to render the graphical scenes. DOUG runs on a laptop running the CentOS4.5 Linux operating system. DOUG is an Open GL-based 3D computer graphics rendering package. It uses pre-built three-dimensional models of on-orbit ISS and space shuttle systems elements, and provides realtime views of various station and shuttle configurations.

Role of dystroglycan in limiting contraction-induced injury to the sarcomeric cytoskeleton of mature skeletal muscle.

PubMed

Rader, Erik P; Turk, Rolf; Willer, Tobias; Beltrán, Daniel; Inamori, Kei-Ichiro; Peterson, Taylor A; Engle, Jeffrey; Prouty, Sally; Matsumura, Kiichiro; Saito, Fumiaki; Anderson, Mary E; Campbell, Kevin P

2016-09-27

Dystroglycan (DG) is a highly expressed extracellular matrix receptor that is linked to the cytoskeleton in skeletal muscle. DG is critical for the function of skeletal muscle, and muscle with primary defects in the expression and/or function of DG throughout development has many pathological features and a severe muscular dystrophy phenotype. In addition, reduction in DG at the sarcolemma is a common feature in muscle biopsies from patients with various types of muscular dystrophy. However, the consequence of disrupting DG in mature muscle is not known. Here, we investigated muscles of transgenic mice several months after genetic knockdown of DG at maturity. In our study, an increase in susceptibility to contraction-induced injury was the first pathological feature observed after the levels of DG at the sarcolemma were reduced. The contraction-induced injury was not accompanied by increased necrosis, excitation-contraction uncoupling, or fragility of the sarcolemma. Rather, disruption of the sarcomeric cytoskeleton was evident as reduced passive tension and decreased titin immunostaining. These results reveal a role for DG in maintaining the stability of the sarcomeric cytoskeleton during contraction and provide mechanistic insight into the cause of the reduction in strength that occurs in muscular dystrophy after lengthening contractions.

SAR Altimetry Processing on Demand Service for CryoSat-2 and Sentinel-3 at ESA G-POD

NASA Astrophysics Data System (ADS)

Dinardo, Salvatore; Lucas, Bruno; Benveniste, Jerome

2015-12-01

The scope of this work is to feature the new ESA service (SARvatore) for the exploitation of the CryoSat-2 data, designed and developed entirely by the Altimetry Team at ESA-ESRIN EOP-SER (Earth Observation - Exploitation, Research and Development). The G-POD Service, SARvatore (SAR Versatile Altimetric Toolkit for Ocean Research & Exploitation) for CryoSat-2, is a web platform that provides the capability to process on-line and on-demand CryoSat-2 SAR/SARIN data, from L1a (FBR) data products until SAR/SARIN Level-2 geophysical data products.. The Processor will make use of the G-POD (Grid-Processing On Demand) distributed computing platform to deliver timely the output data products. These output data products are generated in standard NetCDF format (using CF Convention), and they are compatible with BRAT (Basic Radar Altimetry Toolbox) and other NetCDF tool. Using the G-POD graphic interface, it is easy to select the geographical area of interest along with the time-frame of interest, based on the Cryosat-2 SAR/SARIN FBR data products availability in the service's catalogue. After the task submission, the users can follow, in real time, the status of the processing task. The processor prototype is versatile in the sense that the users can customize and adapt the processing, according their specific requirements, setting a list of configurable options. The processing service is meant to be used for research & development experiments, to support the development contracts awarded confronting the deliverables to ESA, on site demonstrations/training in training courses and workshops, cross-comparison against third party products (CLS/CNES CPP Products for instance), preparation for the Sentinel-3 Topographic mission, producing data and graphics for publications, etc. So far, the processing has been designed and optimized for open ocean studies and is fully functional only over this kind of surface but there are plans to augment this processing capacity over coastal zone, inland water and over land in view of maximizing the exploitation of the upcoming Sentinel-3 Topographic mission over all surfaces. The service is open and free of charge.

Service contract with periodic preventive maintenance for a dump truck sold with a two-dimensional warranty

NASA Astrophysics Data System (ADS)

Nasrum, A.; Pasaribu, U. S.; Husniah, H.

2016-02-01

This paper deals with maintenance service contract for a dump truck sold with a two-dimensional warranties. We consider a situation where an agent offers two maintenance contract options and the owner of the equipment has to select the optimal option either the OEM carried out all repairs and preventive maintenance activities (option one) or the OEM only carries out failure while the costumer undertakes preventive maintenance action in-house (option two). As the number of preventive maintenance and corrective maintenance that occurs in the area of servicing contracts is very influential in determining the value of the contract, we have to determine the optimal time between preventive maintenance that can minimize the cost of repair in the contract area. Moreover, we also study the maintenance service contract considering reduction of the intensity function after preventive maintenance from both the owner and OEM point of views. In this paper, we use a Weibull intensity function to consider a product with increasing failure intensity. We use a non-cooperative game formulation to determine the optimal price structure (i.e., the contract price and repair cost) for the OEM and the owner. A numerical example derived from the model has shown that if the owner choose option one then the owner obtain a higher profit compared with the profit resulted from option two. The result agree with earlier work which uses the accelerated failure time (AFT) for the failure modeling, while here we model the failure of the dump truck without the use of the AFT.

Functional, morphological and electrocardiographical abnormalities in patients with apical hypertrophic cardiomyopathy and apical aneurysm: correlation with cardiac MR

PubMed Central

Suwa, Kenichiro; Satoh, Hiroshi; Sano, Makoto; Nobuhara, Mamoru; Saitoh, Takeji; Saotome, Masao; Urushida, Tsuyoshi; Katoh, Hideki; Tawarahara, Kei; Ohtani, Hayato; Wakabayashi, Yasushi; Takase, Hiroyuki; Terada, Hajime; Takehara, Yasuo; Sakahara, Harumi; Hayashi, Hideharu

2014-01-01

Objective The prognosis of apical hypertrophic cardiomyopathy (APH) has been benign, but apical myocardial injury has prognostic importance. We studied functional, morphological and electrocardiographical abnormalities in patients with APH and with apical aneurysm and sought to find parameters that relate to apical myocardial injury. Methods Study design: a multicentre trans-sectional study. Patients: 45 patients with APH and 5 with apical aneurysm diagnosed with transthoracic echocardiography (TTE) in the database of Hamamatsu Circulation Forum. Measure: the apical contraction with cine-cardiac MR (CMR), the myocardial fibrotic scar with late gadolinium enhancement (LGE)-CMR, and QRS fragmentation (fQRS) defined when two ECG-leads exhibited RSR’s patterns. Results Cine-CMR revealed 27 patients with normal, 12 with hypokinetic and 11 with dyskinetic apical contraction. TTE misdiagnosed 11 (48%) patients with hypokinetic and dyskinetic contraction as those with normal contraction. Apical LGE was apparent in 10 (83%) and 11 (100%) patients with hypokinetic and dyskinetic contraction, whereas only in 11 patients (41%) with normal contraction (p<0.01). Patients with dyskinetic apical contraction had the lowest left ventricular ejection fraction, the highest prevalence of ventricular tachycardia, and the smallest ST depression and depth of negative T waves. The presence of fQRS was associated with impaired apical contraction and apical LGE (OR=8.32 and 8.61, p<0.05). Conclusions CMR is superior to TTE for analysing abnormalities of the apex in patients with APH and with apical aneurysm. The presence of fQRS can be a promising parameter for the early detection of apical myocardial injury. PMID:25332823

Function of Brg1 Chromatin Remodeling Factor in Sonic Hedgehog-Dependent Medulloblastoma Initiation and Maintenance

DTIC Science & Technology

2013-10-01

Remodeling Factor in Sonic Hedgehog -Dependent Medulloblastoma Initiation and Maintenance PRINCIPAL INVESTIGATOR: Xuanming Shi CONTRACTING...5a. CONTRACT NUMBER W81XWH-12-1-0527 Function of Brg1 Chromatin Remodeling Factor in Sonic Hedgehog -Dependent 5b. GRANT NUMBER W81XWH-12-1...drug development and therapy of pediatric brain tumor and other Shh- dependent tumors. 15. SUBJECT TERMS Medulloblastoma, Sonic Hedgehog , Chromatin

Re-animation of muscle flaps for improved function in dynamic myoplasty.

PubMed

Stremel, R W; Zonnevijlle, E D

2001-01-01

The authors report on a series of experiments designed to produce a skeletal muscle contraction functional for dynamic myoplasties. Conventional stimulation techniques recruit all or most of the muscle fibers simultaneously and with maximal strength. This approach has limitations in free dynamic muscle flap transfers that require the muscle to contract immediately after transfer and before re-innervation. Sequential stimulation of segments of the transferred muscle provides a means of producing non-fatiguing contractions of the muscle in the presence or absence of innervation. The muscles studied were the canine gracilis, and all experiments were acute studies in anesthetized animals. Comparison of conventional and sequential segmental neuromuscular stimulation revealed an increase in muscle fatigue resistance and muscle blood flow with the new approach. This approach offers the opportunity for development of physiologically animated tissue and broadening the abilities of reconstructive surgeons in the repair of functional defects. Copyright 2001 Wiley-Liss, Inc.

Graphical method to design multilayer phase retarders.

PubMed

Apfel, J H

1981-03-15

When multilayer reflectors are used at nonnormal incidence, the two planes of polarization generally have different phase shifts. This difference, known as phase retardance, depends on the multilayer design, the incidence angle, and the wavelength. Heretofore, the design of reflectors with specific phase retardance has been carried out by computer optimization except for the case of a single layer on a metal substrate. A graph of phase retardance D vs the average phase shift A as a function of layer thickness provides a means for visualization that is useful in reflector designs. A D-A graph predicts the phase properties of a reflector as a function of the index and thickness of an added layer. Graphs of phase retardance vs average phase for two different materials can be superposed to predict the composite performance of a multilayer reflector. This graphical technique is employed to design and analyze reflectors with specified phase retardance.

48 CFR 732.401 - Statutory authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... the making of advance payments with respect to functions authorized by the Foreign Assistance Act. Advance payments may also be made under section 305 of the Federal Property and Administrative Services... GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments 732.401 Statutory authority. (a...

Acting Out Muscle Contraction.

ERIC Educational Resources Information Center

Hudson, Margaret

2003-01-01

Describes a science activity that can be implemented into anatomy and physiology courses that demonstrates the interactions between action and myosin, the roles of sodium and calcium ions in the regulation of contraction, and the functions of the plasma membrane and the sarcoplasmic reticulum. (YDS)

Hierarchthis: An Interactive Interface for Identifying Mission-Relevant Components of the Advanced Multi-Mission Operations System

NASA Technical Reports Server (NTRS)

Litomisky, Krystof

2012-01-01

Even though NASA's space missions are many and varied, there are some tasks that are common to all of them. For example, all spacecraft need to communicate with other entities, and all spacecraft need to know where they are. These tasks use tools and services that can be inherited and reused between missions, reducing systems engineering effort and therefore reducing cost.The Advanced Multi-Mission Operations System, or AMMOS, is a collection of multimission tools and services, whose development and maintenance are funded by NASA. I created HierarchThis, a plugin designed to provide an interactive interface to help customers identify mission-relevant tools and services. HierarchThis automatically creates diagrams of the AMMOS database, and then allows users to show/hide specific details through a graphical interface. Once customers identify tools and services they want for a specific mission, HierarchThis can automatically generate a contract between the Multimission Ground Systems and Services Office, which manages AMMOS, and the customer. The document contains the selected AMMOS components, along with their capabilities and satisfied requirements. HierarchThis reduces the time needed for the process from service selections to having a mission-specific contract from the order of days to the order of minutes.

Porcine uterus cryopreservation: an analysis of contractile function using different uterotonics.

PubMed

Schölch, Daniel; Schölch, Sebastian; Strahl, Olga; Hoffmann, Inge; Beckmann, Matthias W; Dittrich, Ralf

2012-10-01

Cryopreservation of whole organs has become increasingly successful in recent years, and establishing reliable methods for confirming the success of specific cryopreservation procedures has therefore become extremely important. On the assumption that methods such as histological evaluation do not provide definitive evidence of long-term cryopreservation and that clear signs of conserved function in an organ are good evidence of its viability, contractile function was analysed in porcine uteri (n=60), either after long-term (group A) or short-term (group B) cryopreservation and post-thaw treatment with three different uterotonics. A slow freezing protocol was used to preserve the organs. Fifteen fresh uteri were analysed similarly for contractile function, which was evaluated by measuring intrauterine pressure after administration of oxytocin, prostaglandin E(1) (PGE(1)), and carbachol. After cryopreservation, all but three uteri (95%) showed rhythmic contractions similar to those in fresh uteri except for differences in the heights of contraction peaks, with lower contractions in PGE(1) subgroup B (P<0.05). With the exception of three nonresponsive uteri in group A, there were no differences in contractility between uteri after long-term cryopreservation and fresh uteri. The results of this study thus contribute to the debate on whether slow freezing or vitrification techniques are best for whole-organ cryopreservation. In summary, (1) preservation of muscular function in porcine uteri is feasible with a slow freezing protocol; (2) measurement of contractile function following administration of uterotonics is a useful method of confirming functionality; and (3) long-term cryopreservation does not significantly impair post-thaw contractibility in comparison with fresh uteri. Copyright © 2012 Elsevier Inc. All rights reserved.

EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis.

PubMed

Delorme, Arnaud; Makeig, Scott

2004-03-15

We have developed a toolbox and graphic user interface, EEGLAB, running under the crossplatform MATLAB environment (The Mathworks, Inc.) for processing collections of single-trial and/or averaged EEG data of any number of channels. Available functions include EEG data, channel and event information importing, data visualization (scrolling, scalp map and dipole model plotting, plus multi-trial ERP-image plots), preprocessing (including artifact rejection, filtering, epoch selection, and averaging), independent component analysis (ICA) and time/frequency decompositions including channel and component cross-coherence supported by bootstrap statistical methods based on data resampling. EEGLAB functions are organized into three layers. Top-layer functions allow users to interact with the data through the graphic interface without needing to use MATLAB syntax. Menu options allow users to tune the behavior of EEGLAB to available memory. Middle-layer functions allow users to customize data processing using command history and interactive 'pop' functions. Experienced MATLAB users can use EEGLAB data structures and stand-alone signal processing functions to write custom and/or batch analysis scripts. Extensive function help and tutorial information are included. A 'plug-in' facility allows easy incorporation of new EEG modules into the main menu. EEGLAB is freely available (http://www.sccn.ucsd.edu/eeglab/) under the GNU public license for noncommercial use and open source development, together with sample data, user tutorial and extensive documentation.

Computer graphics and the graphic artist

NASA Technical Reports Server (NTRS)

Taylor, N. L.; Fedors, E. G.; Pinelli, T. E.

1985-01-01

A centralized computer graphics system is being developed at the NASA Langley Research Center. This system was required to satisfy multiuser needs, ranging from presentation quality graphics prepared by a graphic artist to 16-mm movie simulations generated by engineers and scientists. While the major thrust of the central graphics system was directed toward engineering and scientific applications, hardware and software capabilities to support the graphic artists were integrated into the design. This paper briefly discusses the importance of computer graphics in research; the central graphics system in terms of systems, software, and hardware requirements; the application of computer graphics to graphic arts, discussed in terms of the requirements for a graphic arts workstation; and the problems encountered in applying computer graphics to the graphic arts. The paper concludes by presenting the status of the central graphics system.

A STRICTLY CONTRACTIVE PEACEMAN–RACHFORD SPLITTING METHOD FOR CONVEX PROGRAMMING

PubMed Central

BINGSHENG, HE; LIU, HAN; WANG, ZHAORAN; YUAN, XIAOMING

2014-01-01

In this paper, we focus on the application of the Peaceman–Rachford splitting method (PRSM) to a convex minimization model with linear constraints and a separable objective function. Compared to the Douglas–Rachford splitting method (DRSM), another splitting method from which the alternating direction method of multipliers originates, PRSM requires more restrictive assumptions to ensure its convergence, while it is always faster whenever it is convergent. We first illustrate that the reason for this difference is that the iterative sequence generated by DRSM is strictly contractive, while that generated by PRSM is only contractive with respect to the solution set of the model. With only the convexity assumption on the objective function of the model under consideration, the convergence of PRSM is not guaranteed. But for this case, we show that the first t iterations of PRSM still enable us to find an approximate solution with an accuracy of O(1/t). A worst-case O(1/t) convergence rate of PRSM in the ergodic sense is thus established under mild assumptions. After that, we suggest attaching an underdetermined relaxation factor with PRSM to guarantee the strict contraction of its iterative sequence and thus propose a strictly contractive PRSM. A worst-case O(1/t) convergence rate of this strictly contractive PRSM in a nonergodic sense is established. We show the numerical efficiency of the strictly contractive PRSM by some applications in statistical learning and image processing. PMID:25620862

Forearm Muscle Oxygenation Decreases During Low Levels of Brief, Isometric Contraction

NASA Technical Reports Server (NTRS)

Murthy Gita; Kahan, N. J.; Hargens, Alan R.; Rempel, D. M.; Hargens, Murthy G. (Technical Monitor)

1997-01-01

Regional muscle pain syndromes can be caused by repeated and sustained exertion of a specific muscle. Such exertion may elevate local tissue fluid pressure, reduce blood flow and tissue oxygenation (TO2), and cause fatigue, pain and functional deficits of the Involved muscle. Low levels (less than 20% maximum voluntary contraction (MVC)) of prolonged static contraction of the upper extremity are common In many occupational settings and May cause fatigue. The purpose of our Investigation was to determine whether TO2 decreases significantly at low levels of static contraction of the extensor carpi radialis brevis (ECRB).

Capitalizing on the Dynamic Features of Excel to Consider Growth Rates and Limits

ERIC Educational Resources Information Center

Taylor, Daniel; Moore-Russo, Deborah

2012-01-01

It is common for both algebra and calculus instructors to use power functions of various degrees as well as exponential functions to examine and compare rates of growth. This can be done on a chalkboard, with a graphing calculator, or with a spreadsheet. Instructors often are careful to connect the symbolic and graphical (and occasionally the…

Characterization of solar cells for space applications. Volume 6: Electrical characteristics of Spectrolab BSF, BSR, textured, 10 ohm-cm, 50 micron advanced OAST solar cells as a function of intensity, temperature, and irradiation

NASA Technical Reports Server (NTRS)

Anspaugh, B. E.; Downing, R. G.; Miyahira, T. F.; Weiss, R. S.

1979-01-01

Electrical parametric data are presented on BSF, BSR, textured 10 ohm cm, 50 micron advanced OAST cells in graphical and tabular form as functions of solar illumination intensity, temperature, and 1 MeV electron fluence.

Don't wear that button out!

NASA Astrophysics Data System (ADS)

Jue, Brian J.; Bice, Michael D.

2013-07-01

As students explore the technological tools available to them for learning mathematics, some will eventually discover what happens when a function button is repeatedly pressed on a calculator. We explore several examples of this, presenting tabular and graphical results for the square root, natural logarithm and sine and cosine functions. Observed behaviour is proven and then discussed in the context of fixed points.

Metaphors in Mathematics Classrooms: Analyzing the Dynamic Process of Teaching and Learning of Graph Functions

ERIC Educational Resources Information Center

Font, Vicenc; Bolite, Janete; Acevedo, Jorge

2010-01-01

This article presents an analysis of a phenomenon that was observed within the dynamic processes of teaching and learning to read and elaborate Cartesian graphs for functions at high-school level. Two questions were considered during this investigation: What types of metaphors does the teacher use to explain the graphic representation of functions…

A Functional Simulator of Spacecraft Resources

NASA Technical Reports Server (NTRS)

Liceaga, Carlos A.; Troutman, Patrick A.

1997-01-01

The SPAcecraft SIMulator (SPASIM) simulates the functions and resources of a spacecraft to quickly perform Phase A trade-off analyses and uncover any operational bottlenecks during any part of the mission. Failure modes and operational contingencies can be evaluated allowing optimization for a range of mission scenarios. The payloads and subsystems are simulated, using a hierarchy of graphical models, in terms of how their functions affect resources such as propellant, power, and data. Any of the inputs and outputs of the payloads and subsystems can be plotted during the simulation. Most trade-off analyses, including those that compare current versus advanced technology, can be performed by changing values in the parameter menus. However, when a component is replaced by one with a different functional architecture, its graphical model can also be modified or replaced by drawing from a component library. SPASIM has been validated using several spacecraft designs which were at least at the Critical Design Review level. The user and programmer guide, including figures, is available on line as a hyper text document. This is an easy-to-use and expand tool which is based on MATLAB and SIMULINK. It runs on SGI workstations and PCs under Windows 95 or NT.

Designing for adaptation to novelty and change: functional information, emergent feature graphics, and higher-level control.

PubMed

Hajdukiewicz, John R; Vicente, Kim J

2002-01-01

Ecological interface design (EID) is a theoretical framework that aims to support worker adaptation to change and novelty in complex systems. Previous evaluations of EID have emphasized representativeness to enhance generalizability of results to operational settings. The research presented here is complementary, emphasizing experimental control to enhance theory building. Two experiments were conducted to test the impact of functional information and emergent feature graphics on adaptation to novelty and change in a thermal-hydraulic process control microworld. Presenting functional information in an interface using emergent features encouraged experienced participants to become perceptually coupled to the interface and thereby to exhibit higher-level control and more successful adaptation to unanticipated events. The absence of functional information or of emergent features generally led to lower-level control and less success at adaptation, the exception being a minority of participants who compensated by relying on analytical reasoning. These findings may have practical implications for shaping coordination in complex systems and fundamental implications for the development of a general unified theory of coordination for the technical, human, and social sciences. Actual or potential applications of this research include the design of human-computer interfaces that improve safety in complex sociotechnical systems.

An Optimized Multicolor Point-Implicit Solver for Unstructured Grid Applications on Graphics Processing Units

NASA Technical Reports Server (NTRS)

Zubair, Mohammad; Nielsen, Eric; Luitjens, Justin; Hammond, Dana

2016-01-01

In the field of computational fluid dynamics, the Navier-Stokes equations are often solved using an unstructuredgrid approach to accommodate geometric complexity. Implicit solution methodologies for such spatial discretizations generally require frequent solution of large tightly-coupled systems of block-sparse linear equations. The multicolor point-implicit solver used in the current work typically requires a significant fraction of the overall application run time. In this work, an efficient implementation of the solver for graphics processing units is proposed. Several factors present unique challenges to achieving an efficient implementation in this environment. These include the variable amount of parallelism available in different kernel calls, indirect memory access patterns, low arithmetic intensity, and the requirement to support variable block sizes. In this work, the solver is reformulated to use standard sparse and dense Basic Linear Algebra Subprograms (BLAS) functions. However, numerical experiments show that the performance of the BLAS functions available in existing CUDA libraries is suboptimal for matrices representative of those encountered in actual simulations. Instead, optimized versions of these functions are developed. Depending on block size, the new implementations show performance gains of up to 7x over the existing CUDA library functions.

SVM Classifier - a comprehensive java interface for support vector machine classification of microarray data.

PubMed

Pirooznia, Mehdi; Deng, Youping

2006-12-12

Graphical user interface (GUI) software promotes novelty by allowing users to extend the functionality. SVM Classifier is a cross-platform graphical application that handles very large datasets well. The purpose of this study is to create a GUI application that allows SVM users to perform SVM training, classification and prediction. The GUI provides user-friendly access to state-of-the-art SVM methods embodied in the LIBSVM implementation of Support Vector Machine. We implemented the java interface using standard swing libraries. We used a sample data from a breast cancer study for testing classification accuracy. We achieved 100% accuracy in classification among the BRCA1-BRCA2 samples with RBF kernel of SVM. We have developed a java GUI application that allows SVM users to perform SVM training, classification and prediction. We have demonstrated that support vector machines can accurately classify genes into functional categories based upon expression data from DNA microarray hybridization experiments. Among the different kernel functions that we examined, the SVM that uses a radial basis kernel function provides the best performance. The SVM Classifier is available at http://mfgn.usm.edu/ebl/svm/.

Small Interactive Image Processing System (SMIPS) system description

NASA Technical Reports Server (NTRS)

Moik, J. G.

1973-01-01

The Small Interactive Image Processing System (SMIPS) operates under control of the IBM-OS/MVT operating system and uses an IBM-2250 model 1 display unit as interactive graphic device. The input language in the form of character strings or attentions from keys and light pen is interpreted and causes processing of built-in image processing functions as well as execution of a variable number of application programs kept on a private disk file. A description of design considerations is given and characteristics, structure and logic flow of SMIPS are summarized. Data management and graphic programming techniques used for the interactive manipulation and display of digital pictures are also discussed.

An Evaluation and Redesign of the Conflict Prediction and Trial Planning Planview Graphical User Interface

NASA Technical Reports Server (NTRS)

Laudeman, Irene V.; Brasil, Connie L.; Stassart, Philippe

1998-01-01

The Planview Graphical User Interface (PGUI) is the primary display of air traffic for the Conflict Prediction and Trial Planning, function of the Center TRACON Automation System. The PGUI displays air traffic information that assists the user in making decisions related to conflict detection, conflict resolution, and traffic flow management. The intent of this document is to outline the human factors issues related to the design of the conflict prediction and trial planning portions of the PGUI, document all human factors related design changes made to the PGUI from December 1996 to September 1997, and outline future plans for the ongoing PGUI design.

Employing OpenCL to Accelerate Ab Initio Calculations on Graphics Processing Units.

PubMed

Kussmann, Jörg; Ochsenfeld, Christian

2017-06-13

We present an extension of our graphics processing units (GPU)-accelerated quantum chemistry package to employ OpenCL compute kernels, which can be executed on a wide range of computing devices like CPUs, Intel Xeon Phi, and AMD GPUs. Here, we focus on the use of AMD GPUs and discuss differences as compared to CUDA-based calculations on NVIDIA GPUs. First illustrative timings are presented for hybrid density functional theory calculations using serial as well as parallel compute environments. The results show that AMD GPUs are as fast or faster than comparable NVIDIA GPUs and provide a viable alternative for quantum chemical applications.

41 CFR 60-741.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... OFFICE OF FEDERAL CONTRACT COMPLIANCE PROGRAMS, EQUAL EMPLOYMENT OPPORTUNITY, DEPARTMENT OF LABOR 741... Programs of the United States Department of Labor, or his or her designee. (g) Disability—(1) The term... functions incidental to the actual construction. (2) Contracting agency means any department, agency...

Critical Issues: Keys to Successful Contracting

ERIC Educational Resources Information Center

Zopf, Michael

2010-01-01

In today's restrictive school-funding environment, many school districts are evaluating different strategies for providing noninstructional support services to preserve financial resources for the classroom. Among the strategies they are considering on a wide scale is the contracting of support functions, including pupil transportation, custodial…

Directed Energy Non-lethal Weapons

DTIC Science & Technology

2010-06-16

technologies that alter skeletal muscle contraction and/or neural functioning (i.e., neurosecretion) via radiofrequency (RF)/microwave (MW...chromaffin cells and 2) completion of studies on the effect of 0.75 to 1 GHz RF fields on skeletal muscle contraction , using in each study fixed

Electromyography tension and frequency spectrum analysis of some masticatory muscles at rest, isotonic and isometric contractions.

PubMed

Bazzotti, L

1999-01-01

On a population of 52 subjects surface electromyographic recordings of temporals and masseters, simultaneously with mandible dynamic of closure and clenching, were performed, in order to study tension and frequency behaviour in three postural conditions: rest, isotonic and isometric contractions. Frequency was studied using the median resulting from FFT calculation, and a new computing method, which presents the proportion of frequencies making up the whole EMG signal, by steps of 50 Hz. Tension was calculated as well. The results permit us to draw the following conclusions: 1. a period of EMG silence was present in 51 of 52 subjects at mandible closure (SPA--Silent Period Area); 2. SPA onset was before teeth contact (22.5 msec., during the motion of the mandible), while its end was after closure (10.2 msec., during motionless phase of clenching). This allowed to use the SPA as a tool to clearly distinguish isotonic from isometric contraction; 3. the comparison of tension and frequency, expressed as median, showed that at rest a muscle presents low frequency and low tension. In active contraction both increase their values. Nevertheless, in active contraction, while no differences were found in frequency behaviour, tension showed a difference: although higher than at rest, isotonic contraction presented lower values than during isometric contraction; 4. the study performed by the new program showed that the low frequency at rest was due to the high proportion (30-40%) of frequencies of less than 50 Hz, while the increase at function was due to the parallel increase of frequencies comprised between 100 and 250 Hz. Because it is known that muscles are composed of fibers at low frequency and at high frequency of discharge, which play different functional roles, the last finding suggests that the mathematical analysis of the spectrum of frequencies, could provide a functional-histological image of the muscle.

Function and structure in early modern muscular mechanics. Four episodes and a dialogue between Stensen and Borelli on two chief muscular systems.

PubMed

Kardel, T

1997-01-01

The dispute on the movement of skeletal muscles in 1667 between Giovanni Alfonso Borelli, who maintained the ancient movement caused by inflation theory, and Niels Stensen (Nicolaus Steno), who proposed the first recorded theory of fibre contraction, had far reaching implications for understanding the relation between muscle morphology and function. A dialogue is reconstructed from citations from the two authors' main works. They had a similar dispute on the movement of the heart along the lines of the debate in the 1630s between William Harvey favouring contraction and René Descartes favouring swelling. Evidence is provided for the delayed general acceptance of fibre contraction in both heart and skeletal muscles. It is shown that the inflation interpretation of muscular mechanics elaborated by Borelli, Johann Bernoulli, his son Daniel, and by others, was maintained from ancient authors and Descartes in part due to a conceptual block resulting from the mechanical philosophy that denied any force of attraction in nature. The alternative theory, that of fibre contraction, was thought of as self-motion, which violated an accepted mechanical principle and therefore was rejected. In the mid-18th century, Albrecht von Haller recorded no microscopic structures in support of inflation. He adopted the view that contraction in fibres of muscles is generated through an 'irritability'. Research on this entity has taken place ever since with a clear preponderance of studies on single fibre properties and subcellular structures. Haller did not, however, refer to the original contribution of Stensen on fibre contraction. Haller even rejected Stensen's functional architecture of skeletal muscle. This structure, now called the unipennate, or semipennate, actuator, was overlooked and had to await confirmation by anatomical rediscovery and pragmatic demonstration through successful applications in computer models of muscular contraction in the 1980s.

A Computer-Based Atlas of a Rat Dissection.

ERIC Educational Resources Information Center

Quentin-Baxter, Megan; Dewhurst, David

1990-01-01

A hypermedia computer program that uses text, graphics, sound, and animation with associative information linking techniques to teach the functional anatomy of a rat is described. The program includes a nonintimidating tutor, to which the student may turn. (KR)

SystemSketch Poster

EPA Science Inventory

SystemSketch is a dynamic, graphic visualization tool to help stakeholders better understand system context and access information resources.  It is constructed using the Driver-Pressure-State-Impact-Response framework, and functions both as a stand-alone tool and as a component ...

The Evolution of the "Cartesian Connection"

ERIC Educational Resources Information Center

Anderson, Gail M.

2008-01-01

Students often struggle with the connection between algebraic and graphical representations of functions. This overview of the history of the Cartesian coordinate system helps the classroom teacher consider new ways to aid students in making the "Cartesian connection." (Contains 7 figures.)

The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release.

PubMed

Obis, Teresa; Besalduch, Núria; Hurtado, Erica; Nadal, Laura; Santafe, Manel M; Garcia, Neus; Tomàs, Marta; Priego, Mercedes; Lanuza, Maria A; Tomàs, Josep

2015-02-10

Protein kinase C (PKC) regulates a variety of neural functions, including neurotransmitter release. Although various PKC isoforms can be expressed at the synaptic sites and specific cell distribution may contribute to their functional diversity, little is known about the isoform-specific functions of PKCs in neuromuscular synapse. The present study is designed to examine the location of the novel isoform nPKCε at the neuromuscular junction (NMJ), their synaptic activity-related expression changes, its regulation by muscle contraction, and their possible involvement in acetylcholine release. We use immunohistochemistry and confocal microscopy to demonstrate that the novel isoform nPKCε is exclusively located in the motor nerve terminals of the adult rat NMJ. We also report that electrical stimulation of synaptic inputs to the skeletal muscle significantly increased the amount of nPKCε isoform as well as its phosphorylated form in the synaptic membrane, and muscle contraction is necessary for these nPKCε expression changes. The results also demonstrate that synaptic activity-induced muscle contraction promotes changes in presynaptic nPKCε through the brain-derived neurotrophic factor (BDNF)-mediated tyrosine kinase receptor B (TrkB) signaling. Moreover, nPKCε activity results in phosphorylation of the substrate MARCKS involved in actin cytoskeleton remodeling and related with neurotransmission. Finally, blocking nPKCε with a nPKCε-specific translocation inhibitor peptide (εV1-2) strongly reduces phorbol ester-induced ACh release potentiation, which further indicates that nPKCε is involved in neurotransmission. Together, these results provide a mechanistic insight into how synaptic activity-induced muscle contraction could regulate the presynaptic action of the nPKCε isoform and suggest that muscle contraction is an important regulatory step in TrkB signaling at the NMJ.

Changes in power and force generation during coupled eccentric-concentric versus concentric muscle contraction with training and aging.

PubMed

Caserotti, Paolo; Aagaard, Per; Puggaard, Lis

2008-05-01

Age-related decline in maximal concentric muscle power is associated with frailty and functional impairments in the elderly. Compared to concentric contraction, mechanical muscle output is generally enhanced when muscles are rapidly pre-stretched (eccentric contraction), albeit less pronounced with increasing age. Exercise has been recommended to prevent loss of muscle power and function and recent guidelines indicate training program for increasing muscle power highly relevant for elderly subjects. This study examined the differences in muscle power, force and movement pattern during concentric-alone and coupled eccentric-concentric contraction and selected functional motor performances before and after 36-week multicomponent training including aerobic, strength, balance, flexibility and coordination components in elderly males. Vertical force, excursion, velocity, power and acceleration of the body center of mass were measured in two standardised vertical jumps (squatting jump, SQJ; countermovement jump, CMJ). Pre-stretch enhancement during CMJ did not improve performance [i.e., no enhanced maximal muscle power (Ppeak) and jump height (JH)] compared to concentric-alone muscle contraction (SQJ). Nevertheless, pre-stretch enhancement occurred as for similar SQJ and CMJ maximal performance, elderly people employed lower mechanical work, higher mean muscle power (Pmean), shorter concentric phase duration and shorter body center of mass displacement during CMJ. Post training, CMJ Ppeak, Pmean and JH increased in training group (P<0.05) while Ppeak and JH decreased in control group during the CMJ and SQJ (P<0.05). In conclusion, long-term training counteracted the age-related decline in muscle power and functional performance observed in the control subjects, while substantial gains in muscular performance were observed in the trained elderly.

A computer program for processing impedance cardiographic data: Improving accuracy through user-interactive software

NASA Technical Reports Server (NTRS)

Cowings, Patricia S.; Naifeh, Karen; Thrasher, Chet

1988-01-01

This report contains the source code and documentation for a computer program used to process impedance cardiography data. The cardiodynamic measures derived from impedance cardiography are ventricular stroke column, cardiac output, cardiac index and Heather index. The program digitizes data collected from the Minnesota Impedance Cardiograph, Electrocardiography (ECG), and respiratory cycles and then stores these data on hard disk. It computes the cardiodynamic functions using interactive graphics and stores the means and standard deviations of each 15-sec data epoch on floppy disk. This software was designed on a Digital PRO380 microcomputer and used version 2.0 of P/OS, with (minimally) a 4-channel 16-bit analog/digital (A/D) converter. Applications software is written in FORTRAN 77, and uses Digital's Pro-Tool Kit Real Time Interface Library, CORE Graphic Library, and laboratory routines. Source code can be readily modified to accommodate alternative detection, A/D conversion and interactive graphics. The object code utilizing overlays and multitasking has a maximum of 50 Kbytes.

Real-time autocorrelator for fluorescence correlation spectroscopy based on graphical-processor-unit architecture: method, implementation, and comparative studies

NASA Astrophysics Data System (ADS)

Laracuente, Nicholas; Grossman, Carl

2013-03-01

We developed an algorithm and software to calculate autocorrelation functions from real-time photon-counting data using the fast, parallel capabilities of graphical processor units (GPUs). Recent developments in hardware and software have allowed for general purpose computing with inexpensive GPU hardware. These devices are more suited for emulating hardware autocorrelators than traditional CPU-based software applications by emphasizing parallel throughput over sequential speed. Incoming data are binned in a standard multi-tau scheme with configurable points-per-bin size and are mapped into a GPU memory pattern to reduce time-expensive memory access. Applications include dynamic light scattering (DLS) and fluorescence correlation spectroscopy (FCS) experiments. We ran the software on a 64-core graphics pci card in a 3.2 GHz Intel i5 CPU based computer running Linux. FCS measurements were made on Alexa-546 and Texas Red dyes in a standard buffer (PBS). Software correlations were compared to hardware correlator measurements on the same signals. Supported by HHMI and Swarthmore College

The Euler’s Graphical User Interface Spreadsheet Calculator for Solving Ordinary Differential Equations by Visual Basic for Application Programming

NASA Astrophysics Data System (ADS)

Gaik Tay, Kim; Cheong, Tau Han; Foong Lee, Ming; Kek, Sie Long; Abdul-Kahar, Rosmila

2017-08-01

In the previous work on Euler’s spreadsheet calculator for solving an ordinary differential equation, the Visual Basic for Application (VBA) programming was used, however, a graphical user interface was not developed to capture users input. This weakness may make users confuse on the input and output since those input and output are displayed in the same worksheet. Besides, the existing Euler’s spreadsheet calculator is not interactive as there is no prompt message if there is a mistake in inputting the parameters. On top of that, there are no users’ instructions to guide users to input the derivative function. Hence, in this paper, we improved previous limitations by developing a user-friendly and interactive graphical user interface. This improvement is aimed to capture users’ input with users’ instructions and interactive prompt error messages by using VBA programming. This Euler’s graphical user interface spreadsheet calculator is not acted as a black box as users can click on any cells in the worksheet to see the formula used to implement the numerical scheme. In this way, it could enhance self-learning and life-long learning in implementing the numerical scheme in a spreadsheet and later in any programming language.

Application of AI techniques to a voice-actuated computer system for reconstructing and displaying magnetic resonance imaging data

NASA Astrophysics Data System (ADS)

Sherley, Patrick L.; Pujol, Alfonso, Jr.; Meadow, John S.

1990-07-01

To provide a means of rendering complex computer architectures languages and input/output modalities transparent to experienced and inexperienced users research is being conducted to develop a voice driven/voice response computer graphics imaging system. The system will be used for reconstructing and displaying computed tomography and magnetic resonance imaging scan data. In conjunction with this study an artificial intelligence (Al) control strategy was developed to interface the voice components and support software to the computer graphics functions implemented on the Sun Microsystems 4/280 color graphics workstation. Based on generated text and converted renditions of verbal utterances by the user the Al control strategy determines the user''s intent and develops and validates a plan. The program type and parameters within the plan are used as input to the graphics system for reconstructing and displaying medical image data corresponding to that perceived intent. If the plan is not valid the control strategy queries the user for additional information. The control strategy operates in a conversation mode and vocally provides system status reports. A detailed examination of the various AT techniques is presented with major emphasis being placed on their specific roles within the total control strategy structure. 1.

Using a color-coded ambigraphic nucleic acid notation to visualize conserved palindromic motifs within and across genomes

PubMed Central

2014-01-01

Background Ambiscript is a graphically-designed nucleic acid notation that uses symbol symmetries to support sequence complementation, highlight biologically-relevant palindromes, and facilitate the analysis of consensus sequences. Although the original Ambiscript notation was designed to easily represent consensus sequences for multiple sequence alignments, the notation’s black-on-white ambiguity characters are unable to reflect the statistical distribution of nucleotides found at each position. We now propose a color-augmented ambigraphic notation to encode the frequency of positional polymorphisms in these consensus sequences. Results We have implemented this color-coding approach by creating an Adobe Flash® application ( http://www.ambiscript.org) that shades and colors modified Ambiscript characters according to the prevalence of the encoded nucleotide at each position in the alignment. The resulting graphic helps viewers perceive biologically-relevant patterns in multiple sequence alignments by uniquely combining color, shading, and character symmetries to highlight palindromes and inverted repeats in conserved DNA motifs. Conclusion Juxtaposing an intuitive color scheme over the deliberate character symmetries of an ambigraphic nucleic acid notation yields a highly-functional nucleic acid notation that maximizes information content and successfully embodies key principles of graphic excellence put forth by the statistician and graphic design theorist, Edward Tufte. PMID:24447494

SimHap GUI: An intuitive graphical user interface for genetic association analysis

PubMed Central

Carter, Kim W; McCaskie, Pamela A; Palmer, Lyle J

2008-01-01

Background Researchers wishing to conduct genetic association analysis involving single nucleotide polymorphisms (SNPs) or haplotypes are often confronted with the lack of user-friendly graphical analysis tools, requiring sophisticated statistical and informatics expertise to perform relatively straightforward tasks. Tools, such as the SimHap package for the R statistics language, provide the necessary statistical operations to conduct sophisticated genetic analysis, but lacks a graphical user interface that allows anyone but a professional statistician to effectively utilise the tool. Results We have developed SimHap GUI, a cross-platform integrated graphical analysis tool for conducting epidemiological, single SNP and haplotype-based association analysis. SimHap GUI features a novel workflow interface that guides the user through each logical step of the analysis process, making it accessible to both novice and advanced users. This tool provides a seamless interface to the SimHap R package, while providing enhanced functionality such as sophisticated data checking, automated data conversion, and real-time estimations of haplotype simulation progress. Conclusion SimHap GUI provides a novel, easy-to-use, cross-platform solution for conducting a range of genetic and non-genetic association analyses. This provides a free alternative to commercial statistics packages that is specifically designed for genetic association analysis. PMID:19109877

UWGSP4: an imaging and graphics superworkstation and its medical applications

NASA Astrophysics Data System (ADS)

Jong, Jing-Ming; Park, Hyun Wook; Eo, Kilsu; Kim, Min-Hwan; Zhang, Peng; Kim, Yongmin

1992-05-01

UWGSP4 is configured with a parallel architecture for image processing and a pipelined architecture for computer graphics. The system's peak performance is 1,280 MFLOPS for image processing and over 200,000 Gouraud shaded 3-D polygons per second for graphics. The simulated sustained performance is about 50% of the peak performance in general image processing. Most of the 2-D image processing functions are efficiently vectorized and parallelized in UWGSP4. A performance of 770 MFLOPS in convolution and 440 MFLOPS in FFT is achieved. The real-time cine display, up to 32 frames of 1280 X 1024 pixels per second, is supported. In 3-D imaging, the update rate for the surface rendering is 10 frames of 20,000 polygons per second; the update rate for the volume rendering is 6 frames of 128 X 128 X 128 voxels per second. The system provides 1280 X 1024 X 32-bit double frame buffers and one 1280 X 1024 X 8-bit overlay buffer for supporting realistic animation, 24-bit true color, and text annotation. A 1280 X 1024- pixel, 66-Hz noninterlaced display screen with 1:1 aspect ratio can be windowed into the frame buffer for the display of any portion of the processed image or graphics.

77 FR 3288 - International Mail Contract

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-23

... commitment, term, assignment, number of rate groups, and solicitation of reseller's customers. Id. at 4-6. The Postal Service states that the differences, which include price variations based on updated... functionally equivalent to the baseline GREP contract. It states that the differences do not affect the...

41 CFR 105-53.110 - Creation and authority.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 53-STATEMENT OF ORGANIZATION AND FUNCTIONS...

41 CFR 105-53.110 - Creation and authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Creation and authority. 105-53.110 Section 105-53.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 53-STATEMENT OF ORGANIZATION AND FUNCTIONS...

North American study on contracting snow and ice response : final report.

DOT National Transportation Integrated Search

2017-01-01

Snow and ice control operations are a vital function often conducted by state and local transportation agencies. Many states are choosing to contract snow and ice response services, instead of or in addition to the use of in-house forces, to maintain...

The Inhibitory Effect of Shikonin on the Agonist-Induced Regulation of Vascular Contractility

PubMed Central

Je, Hyun Dong; Kim, Hyeong-Dong; La, Hyen-Oh

2015-01-01

Shikonin, a natural flavonoid found in the roots of Lithospermum erythrorhizon, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of shikonin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Shikonin significantly relaxed fluoride-, thromboxane A2- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, shikonin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and the inhibition of MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of shikonin on agonist-induced vascular contraction regardless of endothelial function. PMID:25995821

Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility

PubMed Central

Je, Hyun Dong; Sohn, Uy Dong; La, Hyen-Oh

2016-01-01

Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of fisetin on vascular smooth muscle contractility and to determine the mechanism involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined with molecular experiments. Fisetin significantly relaxed fluoride-, thromboxane A2- or phorbol ester-induced vascular contraction suggesting as a possible anti-hypertensive on the agonist-induced vascular contraction regardless of endothelial nitric oxide synthesis. Furthermore, fisetin significantly inhibited fluoride-induced increases in pMYPT1 levels and phorbol ester-induced increases in pERK1/2 levels suggesting the mechanism involving the inhibition of Rho-kinase activity and the subsequent phosphorylation of MYPT1 and MEK activity and the subsequent phosphorylation of ERK1/2. This study provides evidence regarding the mechanism underlying the relaxation effect of fisetin on agonist-induced vascular contraction regardless of endothelial function. PMID:26759702

Actively Coping with Violation: Exploring Upward Dissent Patterns in Functional, Dysfunctional, and Deserted Psychological Contract End States

PubMed Central

Schalk, René; De Ruiter, Melanie; Van Loon, Joost; Kuijpers, Evy; Van Regenmortel, Tine

2018-01-01

Recently, scholars have emphasized the importance of examining how employees cope with psychological contract violation and how the coping process contributes to psychological contract violation resolution and post-violation psychological contracts. Recent work points to the important role of problem-focused coping. Yet, to date, problem-focused coping strategies have not been conceptualized on a continuum from constructive to destructive strategies. Consequently, potential differences in the use of specific types of problem-focused coping strategies and the role these different strategies play in the violation resolution process has not been explored. In this study, we stress the importance of focusing on different types of problem-focused coping strategies. We explore how employee upward dissent strategies, conceptualized as different forms of problem-focused coping, contribute to violation resolution and post-violation psychological contracts. Two sources of data were used. In-depth interviews with supervisors of a Dutch car lease company provided 23 case descriptions of employee-supervisor interactions after a psychological contract violation. Moreover, a database with descriptions of Dutch court sentences provided eight case descriptions of employee-organization interactions following a perceived violation. Based on these data sources, we explored the pattern of upward dissent strategies employees used over time following a perceived violation. We distinguished between functional (thriving and reactivation), dysfunctional (impairment and dissolution) and deserted psychological contract end states and explored whether different dissent patterns over time differentially contributed to the dissent outcome (i.e., psychological contract end state). The results of our study showed that the use of problem-focused coping is not as straightforward as suggested by the post-violation model. While the post-violation model suggests that problem-focused coping will most likely contribute positively to violation resolution, we found that this also depends on the type of problem-focused coping strategy used. That is, more threatening forms of problem-focused coping (i.e., threatening resignation as a way to trigger one’s manager/organization to resolve the violation) mainly contributed to dysfunctional and deserted PC end states. Yet, in some instances the use of these types of active coping strategies also contributed to functional violation resolution. These findings have important implications for the literature on upward dissent strategies and psychological contract violation repair. PMID:29467692

Actively Coping with Violation: Exploring Upward Dissent Patterns in Functional, Dysfunctional, and Deserted Psychological Contract End States.

PubMed

Schalk, René; De Ruiter, Melanie; Van Loon, Joost; Kuijpers, Evy; Van Regenmortel, Tine

2018-01-01

Recently, scholars have emphasized the importance of examining how employees cope with psychological contract violation and how the coping process contributes to psychological contract violation resolution and post-violation psychological contracts. Recent work points to the important role of problem-focused coping. Yet, to date, problem-focused coping strategies have not been conceptualized on a continuum from constructive to destructive strategies. Consequently, potential differences in the use of specific types of problem-focused coping strategies and the role these different strategies play in the violation resolution process has not been explored. In this study, we stress the importance of focusing on different types of problem-focused coping strategies. We explore how employee upward dissent strategies, conceptualized as different forms of problem-focused coping, contribute to violation resolution and post-violation psychological contracts. Two sources of data were used. In-depth interviews with supervisors of a Dutch car lease company provided 23 case descriptions of employee-supervisor interactions after a psychological contract violation. Moreover, a database with descriptions of Dutch court sentences provided eight case descriptions of employee-organization interactions following a perceived violation. Based on these data sources, we explored the pattern of upward dissent strategies employees used over time following a perceived violation. We distinguished between functional (thriving and reactivation), dysfunctional (impairment and dissolution) and deserted psychological contract end states and explored whether different dissent patterns over time differentially contributed to the dissent outcome (i.e., psychological contract end state). The results of our study showed that the use of problem-focused coping is not as straightforward as suggested by the post-violation model. While the post-violation model suggests that problem-focused coping will most likely contribute positively to violation resolution, we found that this also depends on the type of problem-focused coping strategy used. That is, more threatening forms of problem-focused coping (i.e., threatening resignation as a way to trigger one's manager/organization to resolve the violation) mainly contributed to dysfunctional and deserted PC end states. Yet, in some instances the use of these types of active coping strategies also contributed to functional violation resolution. These findings have important implications for the literature on upward dissent strategies and psychological contract violation repair.

An investigation of electrochemomechanical actuation of conductive Polyacrylonitrile (PAN) nanofiber composites

NASA Astrophysics Data System (ADS)

Gonzalez, Mark A.; Walter, Wayne W.

2014-03-01

A polymer-based nanofiber composite actuator designed for contractile actuation was fabricated by electrospinning, stimulated by electrolysis, and characterized by electrochemical and mechanical testing to address performance limitations and understand the activation processing effects on actuation performance. Currently, Electroactive polymers (EAPs) have provided uses in sensory and actuation technology, but have either low force output or expand rather than contract, falling short in capturing the natural kinetics and mechanics of muscle needed to provide breakthroughs in the bio-medical and robotic fields. In this study, activated Polyacrylonitrile (PAN) fibers have demonstrated biomimetic functionalities similar to the sarcomere contraction responsible for muscle function. Activated PAN has also been shown to contract and expand by electrolysis when in close vicinity to the anode and cathode, respectively. PAN nanofibers (~500 nm) especially show faster response to changes in environmental pH and improved mechanical properties compared to larger diameter fibers. Tensile testing was conducted to examine changes in mechanical properties between annealing and hydrolysis processing. Voltage driven transient effects of localized pH were examined to address pHdefined actuation thresholds of PAN fibers. Electrochemical contraction rates of the PAN/Graphite composite actuator demonstrated up to 25%/min. Strains of 58.8%, ultimate stresses up to 77.1 MPa, and moduli of 0.21 MPa were achieved with pure PAN nanofiber mats, surpassing mechanical properties of natural muscles. Further improvements, however, to contraction rates and Young's moduli were found essential to capture the function and performance of skeletal muscles appropriately.

The functions of language: an experimental study.

PubMed

Redhead, Gina; Dunbar, R I M

2013-08-14

We test between four separate hypotheses (social gossip, social contracts, mate advertising and factual information exchange) for the function(s) of language using a recall paradigm. Subjects recalled the social content of stories (irrespective of whether this concerned social behavior, defection or romantic events) significantly better than they did ecological information. Recall rates were no better on ecological stories if they involved flamboyant language, suggesting that, if true, Miller's "Scheherazade effect" may not be independent of content. One interpretation of these results might be that language evolved as an all-purpose social tool, and perhaps acquired specialist functions (sexual advertising, contract formation, information exchange) at a later date through conventional evolutionary windows of opportunity.

Regulation of Contraction by the Thick Filaments in Skeletal Muscle.

PubMed

Irving, Malcolm

2017-12-19

Contraction of skeletal muscle cells is initiated by a well-known signaling pathway. An action potential in a motor nerve triggers an action potential in a muscle cell membrane, a transient increase of intracellular calcium concentration, binding of calcium to troponin in the actin-containing thin filaments, and a structural change in the thin filaments that allows myosin motors from the thick filaments to bind to actin and generate force. This calcium/thin filament mediated pathway provides the "START" signal for contraction, but it is argued that the functional response of the muscle cell, including the speed of its contraction and relaxation, adaptation to the external load, and the metabolic cost of contraction is largely determined by additional mechanisms. This review considers the role of the thick filaments in those mechanisms, and puts forward a paradigm for the control of contraction in skeletal muscle in which both the thick and thin filaments have a regulatory function. The OFF state of the thick filament is characterized by helical packing of most of the myosin head or motor domains on the thick filament surface in a conformation that makes them unavailable for actin binding or ATP hydrolysis, although a small fraction of the myosin heads are constitutively ON. The availability of the majority fraction of the myosin heads for contraction is controlled in part by the external load on the muscle, so that these heads only attach to actin and hydrolyze ATP when they are required. This phenomenon seems to be the major determinant of the well-known force-velocity relationship of muscle, and controls the metabolic cost of contraction. The regulatory state of the thick filament also seems to control the dynamics of both muscle activation and relaxation. Copyright © 2017 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Developing sustainable software solutions for bioinformatics by the “ Butterfly” paradigm

PubMed Central

Ahmed, Zeeshan; Zeeshan, Saman; Dandekar, Thomas

2014-01-01

Software design and sustainable software engineering are essential for the long-term development of bioinformatics software. Typical challenges in an academic environment are short-term contracts, island solutions, pragmatic approaches and loose documentation. Upcoming new challenges are big data, complex data sets, software compatibility and rapid changes in data representation. Our approach to cope with these challenges consists of iterative intertwined cycles of development (“ Butterfly” paradigm) for key steps in scientific software engineering. User feedback is valued as well as software planning in a sustainable and interoperable way. Tool usage should be easy and intuitive. A middleware supports a user-friendly Graphical User Interface (GUI) as well as a database/tool development independently. We validated the approach of our own software development and compared the different design paradigms in various software solutions. PMID:25383181

Geologic map of outcrop areas of sedimentary units in the eastern part of the Hailey 1 degree x 2 degrees quadrangle and part of the southern part of the Challis 1 degree x 2 degrees quadrangle, south-central Idaho

USGS Publications Warehouse

Link, P.K.; Mahoney, J.B.; Bruner, D.J.; Batatian, L.D.; Wilson, Eric; Williams, F.J.C.

1995-01-01

The paper version of the Geologic map of outcrop areas of sedimentary units in the eastern part of the Hailey 1x2 Quadrangle and part of the southern part of the Challis 1x2 Quadrangle, south-central Idaho was compiled by Paul Link and others in 1995. The plate was compiled on a 1:100,000 scale topographic base map. TechniGraphic System, Inc. of Fort Collins Colorado digitized this map under contract for N.Shock. G.Green edited and prepared the digital version for publication as a GIS database. The digital geologic map database can be queried in many ways to produce a variety of geologic maps.

Wireless physiological monitoring system for psychiatric patients.

PubMed

Rademeyer, A J; Blanckenberg, M M; Scheffer, C

2009-01-01

Patients in psychiatric hospitals that are sedated or secluded are at risk of death or injury if they are not continuously monitored. Some psychiatric patients are restless and aggressive, and hence the monitoring device should be robust and must transmit the data wirelessly. Two devices, a glove that measures oxygen saturation and a dorsally-mounted device that measures heart rate, skin temperature and respiratory rate were designed and tested. Both devices connect to one central monitoring station using two separate Bluetooth connections, ensuring a completely wireless setup. A Matlab graphical user interface (GUI) was developed for signal processing and monitoring of the vital signs of the psychiatric patient. Detection algorithms were implemented to detect ECG arrhythmias such as premature ventricular contraction and atrial fibrillation. The prototypes were manufactured and tested in a laboratory setting on healthy volunteers.

Treatment with a Nitric Oxide-Donating NSAID Alleviates Functional Muscle Ischemia in the Mouse Model of Duchenne Muscular Dystrophy

PubMed Central

Thomas, Gail D.; Ye, Jianfeng; De Nardi, Claudio; Monopoli, Angela; Ongini, Ennio; Victor, Ronald G.

2012-01-01

In patients with Duchenne muscular dystrophy (DMD) and the standard mdx mouse model of DMD, dystrophin deficiency causes loss of neuronal nitric oxide synthase (nNOSμ) from the sarcolemma, producing functional ischemia when the muscles are exercised. We asked if functional muscle ischemia would be eliminated and normal blood flow regulation restored by treatment with an exogenous nitric oxide (NO)-donating drug. Beginning at 8 weeks of age, mdx mice were fed a standard diet supplemented with 1% soybean oil alone or in combination with a low (15 mg/kg) or high (45 mg/kg) dose of HCT 1026, a NO-donating nonsteroidal anti-inflammatory agent which has previously been shown to slow disease progression in the mdx model. After 1 month of treatment, vasoconstrictor responses to intra-arterial norepinephrine (NE) were compared in resting and contracting hindlimbs. In untreated mdx mice, the usual effect of muscle contraction to attenuate NE-mediated vasoconstriction was impaired, resulting in functional ischemia: NE evoked similar decreases in femoral blood flow velocity and femoral vascular conductance (FVC) in the contracting compared to resting hindlimbs (ΔFVC contraction/ΔFVC rest = 0.88±0.03). NE-induced functional ischemia was unaffected by low dose HCT 1026 (ΔFVC ratio = 0.92±0.04; P>0.05 vs untreated), but was alleviated by the high dose of the drug (ΔFVC ratio = 0.22±0.03; P<0.05 vs untreated or low dose). The beneficial effect of high dose HCT 1026 was maintained with treatment up to 3 months. The effect of the NO-donating drug HCT 1026 to normalize blood flow regulation in contracting mdx mouse hindlimb muscles suggests a putative novel treatment for DMD. Further translational research is warranted. PMID:23139842

An entropy-assisted musculoskeletal shoulder model.

PubMed

Xu, Xu; Lin, Jia-Hua; McGorry, Raymond W

2017-04-01

Optimization combined with a musculoskeletal shoulder model has been used to estimate mechanical loading of musculoskeletal elements around the shoulder. Traditionally, the objective function is to minimize the summation of the total activities of the muscles with forces, moments, and stability constraints. Such an objective function, however, tends to neglect the antagonist muscle co-contraction. In this study, an objective function including an entropy term is proposed to address muscle co-contractions. A musculoskeletal shoulder model is developed to apply the proposed objective function. To find the optimal weight for the entropy term, an experiment was conducted. In the experiment, participants generated various 3-D shoulder moments in six shoulder postures. The surface EMG of 8 shoulder muscles was measured and compared with the predicted muscle activities based on the proposed objective function using Bhattacharyya distance and concordance ratio under different weight of the entropy term. The results show that a small weight of the entropy term can improve the predictability of the model in terms of muscle activities. Such a result suggests that the concept of entropy could be helpful for further understanding the mechanism of muscle co-contractions as well as developing a shoulder biomechanical model with greater validity. Copyright © 2017 Elsevier Ltd. All rights reserved.

Interpretation of 2-probe turbulence measurements in an axisymmetric contraction

NASA Technical Reports Server (NTRS)

Marion-Moulin, C.; Tan-Atichat, J.; Nagib, H. M.

1983-01-01

Simultaneous measurements of the streamwise and radial velocity components at two points, one on and one off the centerline with variable radial separation, were digitally recorded and processed at several stations along a four to one contraction with controlled upstream turbulence conditions. Various statistical quantities are presented including spectra and coherence functions. The integral L sub ux, L sub um, L sub vx, L sub vm were also estimated and their variation along the contraction is examined.

An Examination of the Skills, Experience, Training and Education Requirements Needed as a Functional Area 97 Officer in the Army Acquisition Corps

DTIC Science & Technology

1991-12-01

4. No Particular Skill . . . . . . . . . . . .. 68 5. Communications Skill ............. 68 6. Contract Law ...... . . . . . . . . . . 69 7. Empirical...tenets of contract law and the provisions of the regulatory guidelines from the Federal Acquisition Regulation (FAR) to the next highest command’s... Contract Law , another AFIT managed course; and the Management of Defense Acquisition (Executive), taught by ALMC. [Ref.10,pgs 5-6] One of the most important

Medical Logistics Functional Integration Management To-Be Modeling Workshop: Improving Today For a Better Tomorrow

DTIC Science & Technology

1993-06-18

A unique identifying number assigned by the contracting officer that is a binding agreement between the Government and a Vendor. quantity- of -beds The...repair it; maintenance contracts may be costly. Barriers to Implementation • Requires the large amount of funding to link a significant number of ...and follow-on requirements for maintenance, training, and installation. 22. Cross Sharing of Standard Contract Shells A3 2.88 Al112 Local activities

The influence of lower leg configurations on muscle force variability.

PubMed

Ofori, Edward; Shim, Jaeho; Sosnoff, Jacob J

2018-04-11

The maintenance of steady contractions is required in many daily tasks. However, there is little understanding of how various lower limb configurations influence the ability to maintain force. The purpose of the current investigation was to examine the influence of joint angle on various lower-limb constant force contractions. Nineteen adults performed knee extension, knee flexion, and ankle plantarflexion isometric force contractions to 11 target forces, ranging from 2 to 95% maximal voluntary contraction (MVC) at 2 angles. Force variability was quantified with mean force, standard deviation, and the coefficient of variation of force output. Non-linearities in force output were quantified with approximate entropy. Curve fitting analyses were performed on each set of data from each individual across contractions to further examine whether joint angle interacts with global functions of lower-limb force variability. Joint angle had significant effects on the model parameters used to describe the force-variability function for each muscle contraction (p < 0.05). Regularities in force output were more explained by force level in smaller angle conditions relative to the larger angle conditions (p < 0.05). The findings support the notion that limb configuration influences the magnitude and regularities in force production. Biomechanical factors, such as joint angle, along with neurophysiological factors should be considered together in the discussion of the dynamics of constant force production. Copyright © 2018 Elsevier Ltd. All rights reserved.

[Contract learning: effects of professionalization on the student nurse].

PubMed

Jubin, Patricia

2013-03-01

The reengineering of nurse training implies the implementation of self-development, empowering tools and a reshaping of the function of accompaniment during training which becomes a shared function. This work is part of a psycho-socio-educational approach of the accompaniment to self-directed learning and also in the field of practices of health and social work. This study contributes to the identification of the conditions of efficiency of contracting between student nurses, tutors and instructors. It aims to explore the interest of a triangular steering of the learning contract centered on the student's individual project and also the interest of meetings during training as triggers to a process of self-construction of competences. Moreover, the study aims to identify the effects of contract on professionalization. Our study reverts to the basic question of learning by contract as a pillar for the self-directed learning in an alternating training context. The empirical approach takes into account a qualitative study carried out with 15 people (tutors, managers, student nurses and instructors) in 3 health care structures and a quantitative study based on 78 first year students, 106 second year students, and 47 third year students at the same nursing education institute. The study shows that learning by contract is empowering and professionalizing, if the student is placed in favorable conditions of learning and contractual relationship.

PyMOL mControl: Manipulating molecular visualization with mobile devices.

PubMed

Lam, Wendy W T; Siu, Shirley W I

2017-01-02

Viewing and manipulating three-dimensional (3D) structures in molecular graphics software are essential tasks for researchers and students to understand the functions of molecules. Currently, the way to manipulate a 3D molecular object is mainly based on mouse-and-keyboard control that is usually difficult and tedious to learn. While gesture-based and touch-based interactions are increasingly popular in interactive software systems, their suitability in handling molecular graphics has not yet been sufficiently explored. Here, we designed the gesture-based and touch-based interaction methods to manipulate virtual objects in PyMOL utilizing the motion and touch sensors in a mobile device. Three fundamental viewing controls-zooming, translation and rotation-and frequently used functions were implemented. Results from a pilot user study reveal that task performances on viewing controls using a mobile device are slightly reduced as compared to mouse-and-keyboard method. However, it is considered to be more suitable for oral presentations and equally suitable for education scenarios such as school classes. Overall, PyMOL mControl provides an alternative way to manipulate objects in molecular graphic software with new user experiences. The software is freely available at http://cbbio.cis.umac.mo/mcontrol.html. © 2016 by The International Union of Biochemistry and Molecular Biology, 45(1):76-83, 2017. © 2016 The International Union of Biochemistry and Molecular Biology.

Method of development of the program of forming of parametrical drawings of details in the AutoCAD software product

NASA Astrophysics Data System (ADS)

Alshakova, E. L.

2017-01-01

The program in the AutoLISP language allows automatically to form parametrical drawings during the work in the AutoCAD software product. Students study development of programs on AutoLISP language with the use of the methodical complex containing methodical instructions in which real examples of creation of images and drawings are realized. Methodical instructions contain reference information necessary for the performance of the offered tasks. The method of step-by-step development of the program is the basis for training in programming on AutoLISP language: the program draws elements of the drawing of a detail by means of definitely created function which values of arguments register in that sequence in which AutoCAD gives out inquiries when performing the corresponding command in the editor. The process of the program design is reduced to the process of step-by-step formation of functions and sequence of their calls. The author considers the development of the AutoLISP program for the creation of parametrical drawings of details, the defined design, the user enters the dimensions of elements of details. These programs generate variants of tasks of the graphic works performed in educational process of "Engineering graphics", "Engineering and computer graphics" disciplines. Individual tasks allow to develop at students skills of independent work in reading and creation of drawings, as well as 3D modeling.

Topographic Information Requirements and Computer-Graphic Display Techniques for Nap-of-the-Earth Flight.

DTIC Science & Technology

1979-12-01

required of the Army aviator. The successful accomplishment of many of these activities depends upon the aviator’s ability to extract information from maps...Cruise NOE VBI Determine Position VB2 Crew Coordination (Topographic) VB3 Radio Communication VI . TERM4INATION C. Post-Flight VIC1 Debriefing 11LA 1I...NOE FUNCTION: VBI DETERMINE POSITION INFORMATION REQUIREMENT SPECIFICS SOURCE COMMENTS See Function IIIAl ! FUNCTION: VB2 CREW COORDINATION

Loading Ag nanoparticles on Cd(II) boron imidazolate framework for photocatalysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Min; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002; Zhang, De-Xiang

2016-05-15

An amine-functionalized Cd(II) boron imidazolate framework (BIF-77) with three-dimensional open structure has been successfully synthesized, which can load Ag nanoparticles (NPs) for photocatalytic degradation of methylene blue (MB). - Graphical abstract: An amine-functionalized neutral Cd(II) boron imidazolate framework can load Ag NPs and show excellent photocatalytic degradation behavious for MB. - Highlights: • Amine-functionalization. • Neutral boron imidazolate framework. • Loading Ag nanoparticles (NPs). • Photocatalytic degradation of methylene blue.

Understanding squeezing of quantum states with the Wigner function

NASA Technical Reports Server (NTRS)

Royer, Antoine

1994-01-01

The Wigner function is argued to be the only natural phase space function evolving classically under quadratic Hamiltonians with time-dependent bilinear part. This is used to understand graphically how certain quadratic time-dependent Hamiltonians induce squeezing of quantum states. The Wigner representation is also used to generalize Ehrenfest's theorem to the quantum uncertainties. This makes it possible to deduce features of the quantum evolution, such as squeezing, from the classical evolution, whatever the Hamiltonian.

Interactive Computer Graphics for System Analysis.

DTIC Science & Technology

1983-12-01

seven matrices have a maximum size of 10xlO and are named: AMAT BMAT CMAT DMAT KMAT FMAT GMAT ICECAP-II has available four transfer functions which B-1...is: COPY (source) (destination) The valid source and destination variables are: AMAT CMAT PMAT GTF KMAT BMAT DMAT GMAT HTF OLTF CLTF Transfer functions...Function: gtf, htf, oltf, cltf Enter choice of Matrix: AMAT, BMAT , CMAT, DMAT, FMAT, GMAT, KMAT Enter SETUP in order to set up State Space Model Enter

Decision Aiding in Europe: Assessment Report,

DTIC Science & Technology

1983-05-26

does not need extreme realism ; combined to yield an attractive index of rather, he needs a dynamic scene represen- mental workload. In the same...graphic functions but are multicriteria aspirations are often contra- not specifically European. Cinematic dictory and cannot be achieved simulta